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<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0E1</accession>
    <name>A0A0N4U0E1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4376</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0E1"/>
    <dbReference type="WBParaSite" id="DME_0000001601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000001601-mRNA-1"/>
        <property type="gene ID" value="DME_0000001601"/>
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    <dbReference type="OrthoDB" id="5801522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
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    <dbReference type="Proteomes" id="UP000274756">
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    <dbReference type="InterPro" id="IPR000082">
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    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
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    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000001601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29275" checksum="8360B2D1F3D0E41E" modified="2015-12-09" version="1">MSFGFPGRFQRRRESEYDREPRLSKTSVYTCPTVFEPGTGAEFMARSGWNQRSCYKNGTNTTPITFYGASWSKRILTGTVVILAILLIVFIVTTITLFALKVIIINYRHEEISATTPNVLSSQYPRVPSNMLPPPVDLLQSRTFLLDLQVLSQANSAYDNPSNYEYQRASQMILIAMRNLLKRSTLNYYMRDIIMRNIENSGNDLLVRFVLELSVPSGLQINPDIIKNVILSEISQFERQLNGIEVDRKLVISELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0R8</accession>
    <name>A0A0N4U0R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4517</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0R8"/>
    <dbReference type="STRING" id="318479.A0A0N4U0R8"/>
    <dbReference type="WBParaSite" id="DME_0000015701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000015701-mRNA-1"/>
        <property type="gene ID" value="DME_0000015701"/>
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    <dbReference type="OrthoDB" id="5858182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231480" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000015701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22014" checksum="3BEE5C1707225FD0" modified="2015-12-09" version="1">MMLTVILFAIFIHETSSGCCPCSPPPCPPLLPPLCPPLLPLPSPCPPPTICPPAICPPPVICPPPLPPPPPLPPLVCPPPLLPPPCPQLPPPVYVPPPKQDCCCLCANPCRYARARMHGARIFSENTAENDPTCTDPKLKVIIQENMSKDPTKTKRAIQKAVEKSFGGNFNVICSKSDFSYVTYTNTFCQASNDDVTCYAFKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U153</accession>
    <name>A0A0N4U153_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS4675</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U153"/>
    <dbReference type="STRING" id="318479.A0A0N4U153"/>
    <dbReference type="WBParaSite" id="DME_0000031501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000031501-mRNA-1"/>
        <property type="gene ID" value="DME_0000031501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF95">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR C06G4.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000031501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40699" checksum="DB563D4708B858E3" modified="2015-12-09" version="1">MFILFTLKNNFDINKIISRISSPPPPIHGVQLAIVAIPYSLIFIVGIFGNTAVLTYAFFLTRSLKSFVLALGNTIIYIVALSLVDTMVMMSIPFHMTSVILDNWLFGDVACKIYWVLEISNKVCSTFILTAMAFDRYMGICYPGIGRVILNNYLFHPVDAKVIQIAYGDKYVKIDGNITNISKEVCIDGMKKKVRTWVSLCVFILGFLLPGTLMAFFYSNIIFTLRKQKRAFVQTRLPIRRITSYALVVSIFYFMCQTPFWLTQIYGMLMTTLNIKSSPQILLLTYICHMFPFIGAALNWIFYAQFNTQFRKGLTLVSERIVRTNNNRLVNFFFQLFIDIFLISFFKRVFTITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1L3</accession>
    <name>A0A0N4U1L3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4863</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1L3"/>
    <dbReference type="STRING" id="318479.A0A0N4U1L3"/>
    <dbReference type="WBParaSite" id="DME_0000050301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000050301-mRNA-1"/>
        <property type="gene ID" value="DME_0000050301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17097">
        <property type="entry name" value="FERM_F1_ERM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="9">
        <location>
            <begin position="15"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="307"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000050301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="634" mass="74105" checksum="95C4CE6A7AE604F6" modified="2015-12-09" version="1">MGIFSLSPSSGGKNIFVKVSTMDADLERIAIEADWTGRQLYDTVCRIIGLREIWFFGLQFVNKKGIPCWLQMEKKICKQEVPKQEDGSLLFLFLVKFYPEDVEEELIQDITRHLFFLQIKHSILSMQLYCSAEAAVLLASYAAQAIQGDCTPESRLKLSELLPECVIKQYDMSALMWEERIRRWWINNSGQSREDAEMEYLRVAQDLEMYGIQYYPICNKKESDLTLGVSAQGIGIYKDANRITPRPFFSWSEIKNISFKNKTFNMRTMDKSTITFRAKDMSINMSILDLCIGTHNLYLRRRQPDLLEVQQMKVQAKQQKIRRMQEQNRLAREREQRMQAEAERDRYKNEITAANEQIRKIQEAMKKTEETAQLLAEKARMSEEEALILSKRASEAEAECQRMKITQVQAEEAKITLERKARDAELVAHRLLQESDHRNLCMYHNSFLPGDTNWSQGWFMPYGMQNSRNYMGHHPMDSSINSIDGGYQRTDSDNGIYRVESDMNMQLLQFQNAGYLNIPPPDPSTNNQLVPSDLSLLRLEIEKSRASYNEKKDNLKKKMNEFRAEIECLKVEDRQSEHDRIHASNIQMGIDKYSTLRKVLFPNSFQFFFQPYQPLANILAFMASRQIVKREKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1S9</accession>
    <name>A0A0N4U1S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4940</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1S9"/>
    <dbReference type="STRING" id="318479.A0A0N4U1S9"/>
    <dbReference type="WBParaSite" id="DME_0000058001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000058001-mRNA-1"/>
        <property type="gene ID" value="DME_0000058001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935339at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000058001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27750" checksum="1D645649FF997C9C" modified="2015-12-09" version="1">MVFTRSMKRNREQQESVGNQISRRGQRPQEISYDPMEILEATSSSIRRQAIGGVIADAPIAKRKKRIMNLGTENYPIVIGLSPDSDNCVDCSNDIQIMDNPNGNTLGLADDKLKLNKICDNLTCSICLEIIHKCVSIFPCLHKFCAGCLSDWIKMRKSCPKCRNHINDVNDIAQDVTIDNIIVVFLEQYPAHCRAASELEELDRKDEITNRAFRRNGKRGSRLPVFNGVNTVRSFRGRIYDIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1T5</accession>
    <name>A0A0N4U1T5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome activator complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4951</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1T5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1T5"/>
    <dbReference type="WBParaSite" id="DME_0000059101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000059101-mRNA-1"/>
        <property type="gene ID" value="DME_0000059101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000001">
        <property type="entry name" value="Proteasome activator complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000059101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27235" checksum="CD677E05C7E945C0" modified="2015-12-09" version="1">MKASKNHKNSAEDLLIEYKKQVIRDAEKLVLEEFPKKSEQFSYDRLEEIVPKGHISIPLPDELQSQENNVCHFSFPLCTPVFEFVGGVVKCNEKLAVLTDIMRPLLRDAVESVNRVKLWILFLIPRIEDGNNFGVSIQEDTLSEVRTVEGEAASFLDQLSRYFVNRARLVTKVAKYPHVEDYRRAILDMDEKQFTNIRLVLTEMRNHFATLHDMITKNLEKIKTPRNNNAEHMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1W8</accession>
    <name>A0A0N4U1W8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4990</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1W8"/>
    <dbReference type="STRING" id="318479.A0A0N4U1W8"/>
    <dbReference type="WBParaSite" id="DME_0000063001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000063001-mRNA-1"/>
        <property type="gene ID" value="DME_0000063001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="14">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="14">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000063001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19591" checksum="029C049A5FDB534F" modified="2016-06-08" version="2">MIGRLAQNQVNSAAKSKFSGLLKKFCGRFCSFIGFVCVPITFYDLIGYPAIVFGSSMEPTLHGSDSRWWKRDIVWLSKIGPMNPQLGEIITFIPPDDPKALHIKRVAALEGTVVRLKNAGEIFEVPAGCCWMKSDNQQNSKDSSYYGPVSKGLMTARATHIIWPPKRWRNLDPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U236</accession>
    <name>A0A0N4U236_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5071</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U236"/>
    <dbReference type="STRING" id="318479.A0A0N4U236"/>
    <dbReference type="WBParaSite" id="DME_0000071101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000071101-mRNA-1"/>
        <property type="gene ID" value="DME_0000071101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF798">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000071101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24462" checksum="7619FDB1459299E4" modified="2015-12-09" version="1">MASFISKLIRATEISDNCGRKLFALKEKLHLARVQRATIAKAVSAYAVRTCIRFVPKQPFDRDYIVISKQDGCYADFARVGGPQQVSLADECLQYSTIIHEFMHVIGFIHEHQRGDRDTYVNIIWENIIPGAHTDFDKLSTVGLSYYGESYDYFSIMHYESTEGSRNGKNTIEAKQRRFTSLMGKSRDFAPSDINRINRAYNCIPQKFNINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U247</accession>
    <name>A0A0N4U247_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcipressin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5082</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U247"/>
    <dbReference type="STRING" id="318479.A0A0N4U247"/>
    <dbReference type="WBParaSite" id="DME_0000072201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000072201-mRNA-1"/>
        <property type="gene ID" value="DME_0000072201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000072201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24430" checksum="0DFC622D61010581" modified="2015-12-09" version="1">MGKVSDKNLTFCVERHSWMRQILSEEIYSYFLNLIFLNKFQVFNNEQQKANFSDLFLQIESDAHFDFLRSFRRVRVIFKTPESATAAKLLTQHLSFNGTILKSFFAQRIQLHNPIDDGLLKLPPIEKQFLISPPASPPIGWEQCREMAPVVCDFDLMARLAAFSMEDTYEVNDKPKIIIHPADNSEEIPVAQTSLPKTPRPPANFTVLPSPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U259</accession>
    <name>A0A0N4U259_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FGGY_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5096</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U259"/>
    <dbReference type="WBParaSite" id="DME_0000073601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000073601-mRNA-1"/>
        <property type="gene ID" value="DME_0000073601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000073601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9259" checksum="D76449F265CF35A6" modified="2015-12-09" version="1">MHGTIYGIIKNLNRMFPPQILHNNGINTIYLMGNSSKPYYKKAIEYYFHGFSFISADFPSTAAYGAAFSVSKYCDNAQKTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2E3</accession>
    <name>A0A0N4U2E3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5202</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2E3"/>
    <dbReference type="STRING" id="318479.A0A0N4U2E3"/>
    <dbReference type="WBParaSite" id="DME_0000084201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000084201-mRNA-1"/>
        <property type="gene ID" value="DME_0000084201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000084201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30465" checksum="B4AA7F7A6ADB55A1" modified="2015-12-09" version="1">MPYANQPNITITSLNDEVVKFILEDTDLSVANSLRRIFIAEVPTIAIDWVQIDCNTSVLHDEFIAHRLGLIPLISDSVVDRLQFSRDCSCLEFCQECAIEMRLHVRCDDESTRAVTTADLISSTPGVSPACGIAYREINSGEISNEEVLIVKLRKGQEVDMKCVAKKEHAKWNPTCGVAFEYDPENALRHTVLAKPEEWPKSENSQLEEDEYEAPYDPMAKPNKFWFSVESTGALKAENIVLSGVAVLKKKLADLQNQLQREILQQPSAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3D1</accession>
    <name>A0A0N4U3D1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5591</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3D1"/>
    <dbReference type="WBParaSite" id="DME_0000123101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000123101-mRNA-1"/>
        <property type="gene ID" value="DME_0000123101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052860">
        <property type="entry name" value="NRL-GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521:SF7">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000123101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37132" checksum="990933E993750CEA" modified="2015-12-09" version="1">MAEIGYTNGYTTPLSISLSYIELFFNVTSYLFISVFCITLIKEKSFSRNLVIIMVNTAFTYLFYHVSRLTKLIFELWFYDPYQPPPDFTADYLVTITKHATCINIATIVVERIISTFSNINSGKKNCLKTIIFNYSSIILVALQWAVALMIFYLFIKGIIARSLPYLIFAPIYLLGGLIFALLPRIARKINEKNRLKQLQNLQHSLKNRYYYLQNVKAAEILNPIIVSVAFLSTVWIIIGTVRYQFIISDQVNSILRPLYFMIYSIEVDIVSVLLMYKSEWWHRLLNKHSCGSANQDKPKRSGTIAPVRDVDMYFKSYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3F9</accession>
    <name>A0A0N4U3F9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5623</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3F9"/>
    <dbReference type="WBParaSite" id="DME_0000126301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000126301-mRNA-1"/>
        <property type="gene ID" value="DME_0000126301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855683at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040350" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000126301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15574" checksum="E38CD0B577E11AC2" modified="2015-12-09" version="1">MFFLQLLLQIPVVTYCLICISEHKFYEEGKIRQINRSQCTSSTKFCVKVRYWDKDPLKKRGFSLGCDKIDCEDSDDLQDGWNLNGCRKNLDYGTDGEICCCRNDFCNQSTSYRLSFLIILASFMIIFIYLQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3J6</accession>
    <name>A0A0N4U3J6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5662</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3J6"/>
    <dbReference type="STRING" id="318479.A0A0N4U3J6"/>
    <dbReference type="WBParaSite" id="DME_0000130201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000130201-mRNA-1"/>
        <property type="gene ID" value="DME_0000130201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061177">
        <property type="term" value="C:type Is terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900073">
        <property type="term" value="P:regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000130201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20388" checksum="8DDC1355AE622706" modified="2015-12-09" version="1">MRNATETENIGSSDDTNRHSRTKRTALYDILGLTKKATDDEIKRAYRRLALKYHPDKNLEGDPEKTEKFKEINYANAILSNPTKRKVYDEYGEVGLKVLEQFGDDDKVMRLVFRPWFKWLLIICGISTCCWCCCCCGFMFCCNCCCNFCCGKYKPKEFNFEEVFIVFVAVIIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U430</accession>
    <name>A0A0N4U430_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS5878</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U430"/>
    <dbReference type="STRING" id="318479.A0A0N4U430"/>
    <dbReference type="WBParaSite" id="DME_0000151801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000151801-mRNA-1"/>
        <property type="gene ID" value="DME_0000151801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000132">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041474296" evidence="11">
        <location>
            <begin position="23"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="32"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="296"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN55905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000151801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="47806" checksum="9E95A482AD21D774" modified="2015-12-09" version="1">MCHLRWLMVSFLLDLLSMYGSCEQFLNCANDTKIIDNLLKDSYNKHYLPNHPVHVRVDMWVQEVTAVSELTQDFEIDLYINEFWEDPALIFDFMNPCKENISFDDKVLQKLWIPNTCFINSKTAAIHESPFRNVFLMVFSNGTLWTNYRMKLTGPCDMNLKRFPFDKQKCFLTFESFNYNTGEVRMSWNQPYPVMLLKNIELPDFKLANFSVIAVEQMYPAGWWDELTVAFVFKRRYGWYILQGYIPTYVTIFISWISFYLGSRLVSLVFCEELKQIFVTIFTIYIYYLIIKIIFRAIPARTMLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDVWMLSGMMFIFLSLLELAVVGFMSRNEGAPRRVAPRKRSFEMEEIAWKEMPSPRLGLRQVLYFYLQYLMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4D9</accession>
    <name>A0A0N4U4D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6003</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4D9"/>
    <dbReference type="WBParaSite" id="DME_0000164301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000164301-mRNA-1"/>
        <property type="gene ID" value="DME_0000164301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000164301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7846" checksum="549D92CA8D4CCC7B" modified="2015-12-09" version="1">MRQQDNQVGFRPGRGSADQIFMLKRFLEHRFKYITPASFVSSIVQLPSIQLATLWRVMEHDGVPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5A1</accession>
    <name>A0A0N4U5A1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6374</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5A1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5A1"/>
    <dbReference type="WBParaSite" id="DME_0000201401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000201401-mRNA-1"/>
        <property type="gene ID" value="DME_0000201401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000201401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14230" checksum="EE26F76EAA1EB664" modified="2015-12-09" version="1">MNLKVHVTADDQKLINRFARLHQQWREKLFEANKDLENSNDASDELLLLDDSSAIPMKLGSIFIHYDQDSVNNELESLKDKLKSKINQLSRSEMEMQNEMNALKSILYGKFGNSINLETDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6C1</accession>
    <name>A0A0N4U6C1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein zwilch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6821</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ZWILCH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6C1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6C1"/>
    <dbReference type="WBParaSite" id="DME_0000246101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000246101-mRNA-1"/>
        <property type="gene ID" value="DME_0000246101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5556307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018630">
        <property type="entry name" value="Zwilch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995:SF1">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09817">
        <property type="entry name" value="Zwilch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000246101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73781" checksum="A8B8641EF8FE13AA" modified="2015-12-09" version="1">MMSKNGGKSCGDCNQLETLTRNDFIKASEGISLLGNFRARLFKSRDIPILCDFSLYKNLEVLVIDNDYDKSSEQSAAETSIEEKIVNNGEDSIKYGGSPLKFEFLTLSALQAKDGFKSVEHEYFQSANFFNCNPLSEKESAFLMNRLSSWVEPTFSHETLRNIPLWIVTDCKDIHNTIMFGISKSKDSMDYCRIQCFGRGNAVAKKYLLVGHHCQRISGLEERSKAVSVINIIRRTHNVETDYKERVSGFMQISATWNCSDNSLLMIPPLSAPLSVHLLPGWLDSRMPLFGLAVELRFIISLARALRTGSMKWDNLNGSSYELIIDKVKKLIEEERNAKRSTGSKKPFRDFTGRLWKIMLSCNSASTLIDVLKTIFAILRSRTFVVTLHSDNRSQLARLISDSASEKGLILPRLEGLTPIQILLEIGVEDFHRSCTEQFLTNEYVTSKSELDFFLIDGFDKSPEDRADSLLAYYYSLVAMAACKQYLNLNKHQFRTFARQVISKYCLLKISPSSHGICTEMVNKFTIDLSTGLSVMNIPPAIYDIKKPVTWALETIYSKGAVECARTMVHFTKEARFPFVYHGLAKKIDHVELQESFRLDEEGNNDENELKNAKNDRLRNAKKKTFCEDFFDDYYCSVLIARLNLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6D1</accession>
    <name>A0A0N4U6D1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6833</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6D1"/>
    <dbReference type="WBParaSite" id="DME_0000247301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000247301-mRNA-1"/>
        <property type="gene ID" value="DME_0000247301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863471at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF7">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN, CFEM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042237" evidence="1">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000247301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28004" checksum="B68F2E12F8FDDEF0" modified="2015-12-09" version="1">MFLIWLIALIFRVMVKAEQSVFNYPIILPQCKCSDIEDCNTMLEQRFVTCAQESDFLYFKFNAFIDHEYDRQDSYCESILKKVGDSKKIHSCLHADHMAAERLDQCIKKNLGVAGCTNANQPPNITISPLSFGEEFDSQNIFSGGLTSNVQMESKDQFFVLAAYLMCLDHCIMNEIMLKNTRARRSLDVVCAMKLNCALKPLDQGAMNVIKTCQKNLDLGPTKRLQESCECFKNAGLQLKCNTTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6F3</accession>
    <name>A0A0N4U6F3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiq_cyt_C_chap domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6855</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6F3"/>
    <dbReference type="STRING" id="318479.A0A0N4U6F3"/>
    <dbReference type="WBParaSite" id="DME_0000249501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249501-mRNA-1"/>
        <property type="gene ID" value="DME_0000249501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="44"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22635" checksum="2046007BA39EE6D0" modified="2015-12-09" version="1">LDKASAQLCYDCCNRYSFSQLCDGLLRIEFHISNAFFLQYYFSAFGLPDHFTSWFKLTLMHIWMALLRLHVSLEAKAYLRVRHGVLSAFWLDVDNRIPIIIVGFNLRRFPKKSGEEVQSGVIKAEIKKMHGLHLQTLFEYDEGFLSSDAALAGAIWRCLYVEKNCDPIHVNKAVQYIRSTVILCFHCLIIIFWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7P1</accession>
    <name>A0A0N4U7P1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear RNA export factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7170</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7P1"/>
    <dbReference type="STRING" id="318479.A0A0N4U7P1"/>
    <dbReference type="WBParaSite" id="DME_0000301101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000301101-mRNA-1"/>
        <property type="gene ID" value="DME_0000301101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000384">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015245">
        <property type="entry name" value="Tap_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09162">
        <property type="entry name" value="Tap-RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="8">
        <location>
            <begin position="367"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="9">
        <location>
            <begin position="609"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000301101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="660" mass="75482" checksum="7C3E8D4D3800C452" modified="2015-12-09" version="1">MRRGDNTRYHSAKKLTMHRLLQMDHDIAPRYEEDDDSQIPPPRYLLTRRFIRDRLNPNRIVRKAQDGDKLSLASLRNSLENRKERQIQMSSGGSSSSQAVIMNQIRIVRGVSIGKDFLLRAIGQYVDDVKPILLKADRMDIIFFVDNDETASAIQAISRRLRDPVTSSPVTIISKKAPVGFSAVGYAEFNLLKNVLSKRYNPENHSLDLSDFGLDDEFRSKSLYFSLCQNNIMMAVIELIDTCYGSITSLSVKGNRLRFLDHFSCLIYRIKNIRTLDLSSNQIDKASELMKLKGWPVETLFFENNPLCSEYGSAEAYLSAIHGVFPKVTSLDGIPVQRPIDLPDLDEETSIPLPKPSFYGSAECKELIEKFITQYMAIYDSADTNDRKSLIDAYDENATFSLSVENLPDANNSRPSFEYSTYNIYRKMSHNIIHLSKWEHYREKVIHKGAMEIIVQLKKLPPTTHLFDTFVVDVSLIKGNIMCFTLQGFFRDVSSNGKDSIDISSVRYFCRDFVIVNKDEGKIAILSDILFISGVFAERIQRYKTMLTNMMKAFDMVLESSLFSFWKLFQIAVTDFSVKEEQNAEQPTTSNVAISERTPAELAAAGDERLQQLMIESFSRESQMKPDWSRKCLMDQNWNYELAGKAFLAVRDKIPPEAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7T0</accession>
    <name>A0A0N4U7T0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7217</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7T0"/>
    <dbReference type="WBParaSite" id="DME_0000305801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000305801-mRNA-1"/>
        <property type="gene ID" value="DME_0000305801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850381at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040968" evidence="1">
        <location>
            <begin position="16"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000305801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47657" checksum="A12F3FC29DA1358C" modified="2015-12-09" version="1">MQFWTALLPIFVVHCLENTTLQKTDSLPKVPTSIITVPKLEISDENFTNKFPIKNSAVIDHSVNILRRIISIIFVMDLGGKLGEMMDAFIEFALNFTNHCEIIRRNEKGLVKGKVVSSARSEIIAAISATSASTADLNFLSRFFSSTRFMSISSSGISSKTSTIAAKSEMVPGHLSTGNEFAIKSKNKGGGELSLYRQSLDLNEDSTTFDKTTISSTNQSYNKDYIGTCFGKIRSTTGFDSNFRTLMDRYSQTAQVDQIDQLIRQKMVDLCTEKEISETESFLDDQRGSIQIAQLVSLNLTNDEKDRLNVYENINDVTSMRNFFLAKFHALTGEQYKRIQKTYNDILMKFVYGSLKQNIGKFLSKLNSQERNILKAYGITSQPEKINEFIDQKFTKMNLSSDDEDEIRKYVRGLFMSINYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8B6</accession>
    <name>A0A0N4U8B6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7436</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8B6"/>
    <dbReference type="STRING" id="318479.A0A0N4U8B6"/>
    <dbReference type="WBParaSite" id="DME_0000327701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000327701-mRNA-1"/>
        <property type="gene ID" value="DME_0000327701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="179"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000327701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32011" checksum="B9AD00F84BED9521" modified="2015-12-09" version="1">MESFPIPVSFNQKYFKLKRDQLKCGKNLLNQIIYIFIYEQEGCIRSLGYPSANDLYYLPLKHIITKGRRFIAEEGKSVEMPCDVAGAQPENVVIWKRGDHVLFTDEDALHDDQRFELHRENNCEFDNAAFFSFFCKHYSANFQLIINNVEPYDTAAYICSTTAPESSITHYLQMISIPPSVTISPDTRPLLVNVGENVAVKCIGSGNPTPKILWTRKGADMPKNAEIKHGQLRLKHVTVPDSGLYVCEGSNSVGRSAHASIEIFVQNIYSKMSFFLILKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8J2</accession>
    <name>A0A0N4U8J2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS234</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8J2"/>
    <dbReference type="WBParaSite" id="DME_0000336801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000336801-mRNA-1"/>
        <property type="gene ID" value="DME_0000336801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000336801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8612" checksum="37DA11C64FA335E0" modified="2015-12-09" version="1">MAAQLCLSSLQVVAGDGKVVAEIHENANGLQFPNFYRLEYFSKNCRKLLDKQSWVPCVIFNLLLAQLTNRAKISQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8T2</accession>
    <name>A0A0N4U8T2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-Fucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS335</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8T2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8T2"/>
    <dbReference type="WBParaSite" id="DME_0000346901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000346901-mRNA-1"/>
        <property type="gene ID" value="DME_0000346901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052501">
        <property type="entry name" value="Alpha-1-2_FucT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898:SF3">
        <property type="entry name" value="ALPHA-1,2-FUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898">
        <property type="entry name" value="UNCHARACTERIZED GLYCOSOL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000346901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28182" checksum="468EF31691183BFE" modified="2015-12-09" version="1">MPIQILPENTELQYVQFGEAFIRFDNPEKLRSIKAQYILTTGKYFESFKYFDHYRTVIKNLLTCSQTIQAKIVESAKNLFRGDGSHKFCVHIRRGDFVNHPIFLPSEERFTISSTDYVLKKLKKNHSNLSVVAIGDGPRWVENLFANKSLYKNLASTKVYIHEMNEDPAVDICFGMMVCDSILLTSSTSTNGWWIAYVITPKPVFYRRKNSPLHMGRYQPRKSGALDYYLKRWIPLDENIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9C7</accession>
    <name>A0A0N4U9C7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7684</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9C7"/>
    <dbReference type="STRING" id="318479.A0A0N4U9C7"/>
    <dbReference type="WBParaSite" id="DME_0000367901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000367901-mRNA-1"/>
        <property type="gene ID" value="DME_0000367901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935339at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057031">
        <property type="entry name" value="SFR19-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23030">
        <property type="entry name" value="SCAF11-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SFR19-like C-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000367901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14219" checksum="26063B3620DEEB89" modified="2015-12-09" version="1">MGFFRSGVKVNKDSVEKRISTDDPRVNASSRKSASAEDEETGEASVKKHKNGWMFEQARQMLSESLKKRYRQKQIKKEEYKIIMKKGVSALSKRTRLDQQKVDEYADKYVECMIHRRKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9R7</accession>
    <name>A0A0N4U9R7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7852</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9R7"/>
    <dbReference type="WBParaSite" id="DME_0000384701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384701-mRNA-1"/>
        <property type="gene ID" value="DME_0000384701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14980" checksum="06170C73D04DC091" modified="2015-12-09" version="1">MNEFTRCDMCRARLRAFTLSEDQTTWLFPCLHAFCTTCKAKCIGSNAPSYAICHICKSEFPQSHIWSLPNSSECSAPVNLNFSFFFGGLPRDIKELDCNLCLKSKEIRTGLDLGKAKRSFLEEGATALELLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA11</accession>
    <name>A0A0N4UA11_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7962</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA11"/>
    <dbReference type="WBParaSite" id="DME_0000395701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000395701-mRNA-1"/>
        <property type="gene ID" value="DME_0000395701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017643at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000395701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="57911" checksum="E405C0C2E20A5ACB" modified="2015-12-09" version="1">MARLLICSVWNSRSRLSLFSLLLALLNILVLLVDDLPQLNTVETFRDDIDYVLETFQYMNDLQYGKAAVRSVFEKARDVREFWRCYLSWPKNFVEQGWIKNDDYFLFSATYDRRSNSLYPSNHAIQVIINSYFHISIFSVEVYCNIYNMKNGKYIVVKGVVREIWQRAWDPRDYFYIPNLLTCPLPNRFSNNNHLAVSITVTLCNSNSKAILSLLFVTFKGMDFLDDISQKLIEWIEMQFLLGADTITVYTYYIHPKVQKVLDYYSTKRFLTVVPLDLPGNSPNQNYIRSKFIWRNRQQKRRHELIPYNDCLYRHINTHKYILILDIDEVIVPLKHMDWESFIREVERNNTKHDITSISIRNVFKFPLKQSNTSYPEYMYLLRNQRRSETISKPGDYGKSFVSTKSVATVFNHFALHRLYQNVSKTIYIKEEIALKLHYKNECPIESRMECSQLKTITINDTSLDRFADKLIESVENTLNDLNLWKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA80</accession>
    <name>A0A0N4UA80_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS401</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA80"/>
    <dbReference type="STRING" id="318479.A0A0N4UA80"/>
    <dbReference type="WBParaSite" id="DME_0000403701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000403701-mRNA-1"/>
        <property type="gene ID" value="DME_0000403701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868535at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000403701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18103" checksum="BADF824907570053" modified="2015-12-09" version="1">MSDPDGHCFFIKNGQRFGDPVYKIALNTNDLKKTVGSDNFACLKKTCHIEWKKINDIIDRGSGFGRIAFAITTSQLGPLQEKMRDAGTTIEVPLVRLDTPGKATVEVVIFVDPNGHEICFVGEEAFCDLSKIDTNADALLKEAILVDESDHWFKDGKPGNLTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAI1</accession>
    <name>A0A0N4UAI1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatase and actin regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8041</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAI1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAI1"/>
    <dbReference type="WBParaSite" id="DME_0000415801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000415801-mRNA-1"/>
        <property type="gene ID" value="DME_0000415801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000415801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="34379" checksum="2B8FBF4B2A3A5764" modified="2016-06-08" version="2">FHILDSWRFKDWQYRNDDDDSDSSYQAEVVTHKSTVIEEIAIKEPNLFAQPDRPALKKPGAPSRLRLVKGASSSRIVADELPSRLTDDSDSDTDIQYRDDFISQAPYRGIDDIISKLSKFLNYNMKGLLLNFEISFIIRRDTFAKRFDVPDPVDDIPNQTSDDRMRLMHKVSIKLERKLSERPSAKELEQRNILKSSDASISSKKAMDETRKMLLRKLSFRPTIQELKDKQIIKFNDYVEVTEAEFYDRKADKPWTRLTPTDKALIRKELNDFKAKEMDVHEESRIFTRFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAK2</accession>
    <name>A0A0N4UAK2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8067</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAK2"/>
    <dbReference type="WBParaSite" id="DME_0000418401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000418401-mRNA-1"/>
        <property type="gene ID" value="DME_0000418401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869531at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055514">
        <property type="entry name" value="DUF7087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23346">
        <property type="entry name" value="DUF7087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7087" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000418401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14558" checksum="D8ACC034291DEB38" modified="2015-12-09" version="1">MESDRIGKYFVIPVAVHCVNLYHTGKRFYYNIDGRFDFSQMLTVKNLMLKAKYASGYKVPSQVTKYLLFFLALFGSILLAVTSHYLITKIPAILSALIYYLSDYATLIASMITVSLEIYKSVKEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBA3</accession>
    <name>A0A0N4UBA3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras-related protein Rab-11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8355</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBA3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBA3"/>
    <dbReference type="WBParaSite" id="DME_0000447201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000447201-mRNA-1"/>
        <property type="gene ID" value="DME_0000447201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000447201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23932" checksum="AE1F81E0D8B07AAC" modified="2015-12-09" version="1">MGSRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHITYENVERWLKELRDHADQNIVIMLVGNKSDLRHLRAVPTDEAKTYAEKNQLSFIETSALDSTNVEAAFTNILTEIYKSVSVKHVGGDNRSMISPPGSNGIVISPTTEPQTKKQCCSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC74</accession>
    <name>A0A0N4UC74_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SVWC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8737</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC74"/>
    <dbReference type="WBParaSite" id="DME_0000485401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000485401-mRNA-1"/>
        <property type="gene ID" value="DME_0000485401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000485401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9445" checksum="4D36616E7E17AF65" modified="2015-12-09" version="1">MVARHSMKRIRTEELNCEYVLPSKNEHMTAAEKSESNAVVRSCDPSKDNCGQTNCYIVQGGYSPQVMQVPPSNVCCMYRYCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCQ4</accession>
    <name>A0A0N4UCQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8857</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCQ4"/>
    <dbReference type="WBParaSite" id="DME_0000505801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000505801-mRNA-1"/>
        <property type="gene ID" value="DME_0000505801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799120at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000505801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="50165" checksum="E47AAD6988AF0B66" modified="2015-12-09" version="1">MDNTVKSSSRKSFMQEYQISDAPSEISSMQKTNSDELNSFERKLVLFDKQIELARKRRDDYLNFLKLKYPSWDPHNFLPLKNSSESSISKRLTNHLSTNIYHWDLNRLKLYQAKQSPCLEPNDPIPKNGTLMDIDLIHMKKRLQEISNDLYRFRNHRLSLSTQEFYQIQSPIIINSIKTDKFDKFLEIKKKINSIDPQLYSEQEATPADLDNFRAEQLMENYINEQKWKEEKQESFIHNSNNLSERKNLDATLDECIQPNELPPSSVRIPQEIIGGSTMKQRNKILDRDAKDKNLLTNFLSEEKNNQPLDNTTNLSGKIFFDGRKTSNYKKMIDIFKDANSSASEDDSEGSDDAKVAKQKSNTLKIDDGNNVRPSNVATRKNEDKLKENGENFLTKVLGETIPKKIQQLSSSNSDILKNITDHESDSDSDFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDC0</accession>
    <name>A0A0N4UDC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9118</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDC0"/>
    <dbReference type="WBParaSite" id="DME_0000531901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000531901-mRNA-1"/>
        <property type="gene ID" value="DME_0000531901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5853260at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000531901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54777" checksum="DC2862ABFF65D618" modified="2015-12-09" version="1">MFNLKKELPEPIPFIDLTVNEEPLDDVHKLYCHFEEACEWHNLNVSGLFWVRTGIKLEKLDLKVTSGTEITPDGFYAAIAPSFTFDKDDEAVLVSRKIDCQKGNGLLKFRFWTGFGAVIEVCTKRTDINQNSKFEECIRLPENIEPGPAHVKIRDIKQKPFRIYIKASHFNPSKTTIKGGFAIVDDIEYFADLCASQTQTTMKTTIPKTTSIITTQTTKSVKPGVSSKAPSTTNPQASTLPEQTSSIKVTSSQKLNNVTLSPTTNVTSANNPTQVVTSTSTSSTTNTVLTTTTVIQSTSSTRRRRRKTTTSSSPNTTVIQTTTISASVQASQTSPPKRVLKTPKVETTKPFRSICLTFDCSFTNEDECSSEIHGSRWKIHNGTDDQKWEKIFGKPIRIKNGQAAVFAYLNGPVTESSLYISSFETMDDFQLFFAYNLPSELSEIEIFAKRENEREKSFFKANGEAKEFTRHWHWMVASMAKGSYDYVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDI2</accession>
    <name>A0A0N4UDI2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9195</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDI2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDI2"/>
    <dbReference type="WBParaSite" id="DME_0000539601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000539601-mRNA-1"/>
        <property type="gene ID" value="DME_0000539601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000539601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="650" mass="73317" checksum="C358FB1DDBB02F32" modified="2015-12-09" version="1">MLFIIAIQGTYLGYTVGILTNLEKRFSIPSKKSGLLLSIYDIGHTLAVMIIGFMAMSKNQARITAFGVLFSALSMFLLILPAFIFGPVANDQKSLIQDKQVYILNNVCDPSRSFSGLIELCEEEKKEHLEAYLVLAVGQLLAGIAAAPFNTVAYVYIDDNLFDKTMSPFYLGLLSSMYAFGPAFGFALSAGVTRLYATVFEAPANLNIYDDEWIGAWWLGFLVCGVLYLFGAIPIFFFPKSFDNLYGKTDPIELNHLRSKEFDDQDAHENENLREIDRNSEKTDFIRPQNLLQFYLHFCSMTIELLRNPVFLSMVIGWMFGSYLTGGYTTYLPKYIETQFAQSSSAADMYAGLISIGSIAASTALGGYLLTKFDLKASKAILCLLASWSIIFATYLFGMTIGCNEPELKDLVLANRRYEFRDISECNFECHCYNVHHFNPVHYGNLNFFSPCHAGCRIFNDDLKRWDQCSCAFDEAVENGLYLEKCEQIFIYIIVVFIGMFFGNLFFMTTIMIILRSVFDYQKVMALSIASCFTNLLGFIPAPIIFGYILDSTCMLWHSRCPDDYGNCVVYDNKLFRQNFHLSSASSQALAVISIFVCYLFSRKHTFFDNMAVCDSMDSTPSNTPTLSIKEIKYQTSLDVNLPSPITAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDL5</accession>
    <name>A0A0N4UDL5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SWIRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9229</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDL5"/>
    <dbReference type="STRING" id="318479.A0A0N4UDL5"/>
    <dbReference type="WBParaSite" id="DME_0000543001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000543001-mRNA-1"/>
        <property type="gene ID" value="DME_0000543001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000543001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38572" checksum="0091A115F5F1E154" modified="2015-12-09" version="1">MGDRAKNSNRKTYDCLMNGDYSSVLAIMTCSLALKRPLEFNDHIRGDSPKEIKRARTAFGYCSPFPTPQAELIARMPSSKSNNVSLANVHSQLATEALPFVNNRFTIDEFVSYMKSGITKDLPNEFKNVISKRPVQEEVPKIESNGVPYESLKPNCANNNSSFCDVSEKISLTEGQLESYLRAEVRYLRRRHLIARRLRNYDPLENFENTLGKLEKSVEMQNKMIGNHNPQNVYRSPNSPTGSTSSDSDGESFALAGRNIKAKQLSQEMKEKPQFSIKEVRMICERLLKQQEAKLRYEYETVIADRLQMKHDEYVEMAEKELVRQRETSAENLSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDM5</accession>
    <name>A0A0N4UDM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inhibin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9240</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDM5"/>
    <dbReference type="STRING" id="318479.A0A0N4UDM5"/>
    <dbReference type="WBParaSite" id="DME_0000544101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000544101-mRNA-1"/>
        <property type="gene ID" value="DME_0000544101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10047996at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000544101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59448" checksum="496855107CE48404" modified="2015-12-09" version="1">MLSHAKKCDNVVTSLSSSYLHYENRRRRFHHFHFHHYYYHHHRHRRRRRRPYSLLNYQQQLINGGGGGVGVGGAFYQSQQEDQFISQKNSRSYLLNNHYKLKYSLKGCCTINFPLKNRFKLRNLIEKQYREKKKLQQRQQQQQQQQLRQRRQERQRQKFHLENLRQEQKLQQFYTSPSTSLSILACLFATGFCLNPPSSSSIIPISSSPSSLNEIIYSNTSSNMYSCPARQNPLLRISRKAALKKSAMSYLLTSITIHELCSMRPLKRYEYFNKIYLFPYEINNNVRLSQLFLFNEKEILDENDIITKHLAYHARSCVISTNLTICKNCFAQIDEGLRKIERAYINFNKTLHRFDCMLAIDSPSATRPFSPNGTCDDCKVWYHRWLLVQFVDVWLEAPCINWCYYAQLACPHLATSKVADYAGHPSFQCRDLQIPRMTSTKKIRKKISSILPAECHCLHPCDLFPTTFSNLFASSNISESTQFLAKLLQNHRVRRHSSRNIVDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDS6</accession>
    <name>A0A0N4UDS6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS607</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDS6"/>
    <dbReference type="WBParaSite" id="DME_0000550101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000550101-mRNA-1"/>
        <property type="gene ID" value="DME_0000550101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000550101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8621" checksum="1F08A6E0A2E44839" modified="2015-12-09" version="1">MSELLDDRNRIAAFGCGDVQTVSLPPSASRSELFSNFSQTASFLLSALFFQLLITRVSLSHFKRYGWPLAFGRLKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEN0</accession>
    <name>A0A0N4UEN0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS835</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEN0"/>
    <dbReference type="STRING" id="318479.A0A0N4UEN0"/>
    <dbReference type="WBParaSite" id="DME_0000584101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000584101-mRNA-1"/>
        <property type="gene ID" value="DME_0000584101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000584101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28797" checksum="8FF163B6A6A93FEE" modified="2015-12-09" version="1">MERYDRAITIFSPDGHLFQVEYAQEAVKKGSTAVGIRGKNCVVIGVEKKTIPTLQDDRTIRKIHSIDEHVMLAFAGLSADARVLVDRARIECQSYKLTLEDPVTVGYIARFVANTKQRFTQSPGRRPFGISMLIGGFDYDGTPRLFKTEPSGAYYEYTANSTGRGEKPVREYLEEHYSEETTADEASVLKLVVKALSQVVQSGAQNIEIAVMRPSDKLGHVDYRILPVEEIEELIKIVEVERAEAEAEEASKKGPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEY1</accession>
    <name>A0A0N4UEY1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-seryl-tRNA(Sec) kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS900</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEY1"/>
    <dbReference type="STRING" id="318479.A0A0N4UEY1"/>
    <dbReference type="WBParaSite" id="DME_0000596101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000596101-mRNA-1"/>
        <property type="gene ID" value="DME_0000596101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000596101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33049" checksum="0868DD812013B1E4" modified="2015-12-09" version="1">MALVLVMGVPGSGKSALCRWLLEVLGNQNCSVFSFDEIFRDDGFLDYIWPESDNFASLLGLYGINGGLSLKEERKRCENLIREELRKRCESNEQYDRIVLVDDIFYLRSMRRPFERIAKRFGLHFGIIYVNVSLDTAIKQNEQRRGASKIPKETIHKIYRKIEMPRTNESLFLYGPNSSKEEVLIFLKSLYKLKQQKSSRLEGKVNKNCGNLSQNAGDDIWRKLELDLRKCVGELIKEHNGILSTTKSKFPKAKKNIVAIFRRENIIQWNHVDLKATLWKNVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFE9</accession>
    <name>A0A0N4UFE9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9453</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFE9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFE9"/>
    <dbReference type="WBParaSite" id="DME_0000615701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000615701-mRNA-1"/>
        <property type="gene ID" value="DME_0000615701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000615701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20172" checksum="2A29179086CEF5C4" modified="2015-12-09" version="1">MKEAAELRNPTEMYFAQPLDDNLFEWHFTVRGPADTDFDGGIYHGRIVLPPDYPMKPPGVILLTPNGRFQLNQKICLSISGHHPESWQPSWSIRTALLALIGFMPTHPAGALGSLEYPSEERKKLALSQNWVCKQCGLCMRDALAKQPSAEEIKLVEEEARNLASKVSFRVNFFRLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFF4</accession>
    <name>A0A0N4UFF4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9459</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFF4"/>
    <dbReference type="STRING" id="318479.A0A0N4UFF4"/>
    <dbReference type="WBParaSite" id="DME_0000616301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616301-mRNA-1"/>
        <property type="gene ID" value="DME_0000616301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47490" checksum="7E79EEA84AE6921B" modified="2015-12-09" version="1">MCFLQLFFCISLHQEHVPIELKTNLGKIRGTESIFLHRRVRSFLGVPFAEPPVGSNRFKPPKPIAKWSHTVDAVKLPPACYQGKDSFNGSTTFWGIAMWNANTEVKEDCLYMNIWVPAEANNLTVMVWLFGGGFYSGSASLQLYDGKALSLLTNSVIININYRVGPFGYLYFNHEDAPGNIGMLDQQLALRWIKENIESFGGNPTQITLFGESAGAASIVAHMIAPGSRDLFRNGILQSGSLDNKWSLESPKRALEKSHKLAKSLNCWKDQLQDTINCLRELPPSKLIGNMWSNLEFLEFPFVIVSKDRNFFKNYDALVALREGNFNKNINIMIGINHDEGNFWNIFNLAEYFNRKEQPHLNREDFLKCVQTAFHAHANIVQNAAAFIYLDQQCEYGDNKVEFFANQVEIEIILVKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH23</accession>
    <name>A0A0N4UH23_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid synthase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
            <ecNumber evidence="2">1.3.1.39</ecNumber>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
            <ecNumber evidence="4">2.3.1.85</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="70" type="ORF">DME_LOCUS1432</name>
    </gene>
    <organism evidence="71 73">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="73" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="70 72" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="62">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="62">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="55">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="58">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="58">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="59">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="59">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="60">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="60">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="51">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="61">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="61">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="63">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="63">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EC" id="1.3.1.39" evidence="2"/>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EC" id="2.3.1.85" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH23"/>
    <dbReference type="STRING" id="318479.A0A0N4UH23"/>
    <dbReference type="WBParaSite" id="DME_0000681801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000681801-mRNA-1"/>
        <property type="gene ID" value="DME_0000681801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.20">
        <property type="entry name" value="Fatty acid synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="65" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="21" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="66" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="72" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="66" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="66" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="66">
        <location>
            <begin position="1731"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="66">
        <location>
            <begin position="1771"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="68">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="69">
        <location>
            <begin position="884"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="67">
        <location>
            <begin position="2215"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="64">
        <location>
            <begin position="884"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="64">
        <location>
            <begin position="1025"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="65">
        <location>
            <begin position="2301"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="64">
        <location>
            <position position="922"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="64">
        <location>
            <position position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
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    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
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    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
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    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047300"/>
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    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047394"/>
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            <dbReference type="ARBA" id="ARBA00047400"/>
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    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
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    </evidence>
    <evidence type="ECO:0000256" key="38">
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            <dbReference type="ARBA" id="ARBA00047451"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
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    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
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    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
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    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00047897"/>
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    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00047953"/>
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    </evidence>
    <evidence type="ECO:0000256" key="44">
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            <dbReference type="ARBA" id="ARBA00047961"/>
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    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
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    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
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    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
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    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00048420"/>
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    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
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    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00048571"/>
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    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00048650"/>
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    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00048691"/>
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    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="ARBA" id="ARBA00048704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="ARBA" id="ARBA00048935"/>
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    </evidence>
    <evidence type="ECO:0000256" key="55">
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    <evidence type="ECO:0000256" key="56">
        <source>
            <dbReference type="ARBA" id="ARBA00049109"/>
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    <evidence type="ECO:0000256" key="57">
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    <evidence type="ECO:0000256" key="58">
        <source>
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    <evidence type="ECO:0000256" key="59">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="63">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
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    </evidence>
    <evidence type="ECO:0000256" key="64">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="65">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="66">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="67">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="68">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="69">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="70">
        <source>
            <dbReference type="EMBL" id="VDN51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="71">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
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    </evidence>
    <evidence type="ECO:0000313" key="72">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <evidence type="ECO:0000313" key="73">
        <source>
            <dbReference type="WBParaSite" id="DME_0000681801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2586" mass="288663" checksum="7EE6EFB91AC02BE4" modified="2016-06-08" version="2">MNSSGEAPFWRDQEDIVISGISGRFPRCDNVQEFGDLLLEGEDLVTEDDLRWPPGIFDLPKRHGKLKELKKFDAQYFGVTPKQANYLDPQIRKLLEVTFEAIIDAGYNPVELRGSRTGVFVGCSVSETGGALTQDPETVTGYTLTGCVRSMFSNRLSFTFDLRGPSFSVDTACSSSLCAMQLAIDAIRQEQCEAAIVAGAHLNLTPTAALQFLRLGMLSDKGSCRSFDASGDGYCRTEAIAAILLQRESAARRIYATVLHAKSNTDGFKEQGITFPSGERQAALLEEVYREAGIDPNVVTYVEAHGTGTKVGDPQEANAICQVFCQNRTPALLIGSVKSNMGHAEPASGLCSIAKVIIAMETGFIPPNLHYTEPNPYIPGLVDGRIKVVSEKTSFPRGIVGINSFGFGGSNTHVILRSANHSERKPAPTTFMKIVTYAGRTNEAVMNIFDSIITNANNPYFQQLLANQANMPAKDLPFRGYMILDRDKIPVPKEVKRNPELPPLRDVQKILITEPKQIYFIYSGEYLNIFNIQPNFLEINLSILYEENVLNSGMGSQWPGMARQLISIPAFDESLRISSAAVKDFGYDVYSMLQKDDAELYKNNTLNCMLAITAIQIALTDVLSLMGVHPDGIIGHSTGEMCCGYADGGLTREQTMCLAYYRGSTIMNGKIEGSMAAVGLTWEKAKARCPPGVVPACHNGADTVTISGDTEVVKKMVEELQQEDIFAKNVEESMLKAMRTVIPNAKPRTSRWISTSIPESEWDSELAQMCSAEYHTNNAMSPVLFYESLQKVPPNAVTIEIAPHCIMNAILRRSLQKTCTNVGLMNSKEKERELEAFLQALGKIYQTGVTIHVEALYPSVQYPVPVGTPMISSIWRWDHSQDWPVIDGKTLSAAGGGQVAATASYTIDPFAADSKETYLLDHMIDGRILYPFTGHMVLAWKAIAKLRGVDYQKTPVILQDINVYSATIVTKPFRLDVIITPGNGYFEILDGEQLAASGNIQIVDENVPFYYKDFDMIETSQLAERIELDTEDAYKEFLLRGYEYGQSFRGIYRTCNSGERGMLYWTGNWVTFLDSLLQTALLAERGDSLRLPTRVRYLRIDPIKHLEHIIEKDGIQVIELRNDIATRGCIAGGVECCDLTAHTVSRRMQSAGQIFYEKIYFVNHFDDHALDEFPRHRNALINYRSFIRSILANGLAKWEVAGVLKKFKNGELLSDAVKSIANYMTSVSDVEHKMWLEDSKSSVAVAFDEIFATEIGADIDEFERKIAEKMSAMMKIMDHDRLWSGALVHDRIIKAILDMCMENSAGHKSKICAVELNTTDQLKICLDALSSHPLIEVESLCVGPKVDSMDESSLLQLGSKKYKVDLDDKKASFAIEMQNCNVLLLDKVLSRKKDIVSYLNKCKELLIDDGFMVIIEPTSDFEIALAIQGLLGEDLKIGDSHRKFGTYFTHENLVKIFSECNLRLCNYQTDPSLMTTTYAIRKISSLPKDPVIVDVDDIKEFSWIEPVQTIIEERLNEPDNKTIWLTSTTVRNNGVVGLALCFREENLKSNRFRTLLDLSIKPENRTGKPQLKLDDENVKHLMDLDLHANIYRDGKWGSLRHFVVKEDEMHQYKEVQHAFINTLVRGDVSSLTWFESPNQFFDDFAKDNHCEMEMCYVYYAAINFRDVMLAYGRLPPDAIPGQFADRECLLGTEYSGRLKDGTRVMGILPAQALATSVLANPGFYWIVPDSWSLADAATVPVVYSTAYYALVIRGQIRKGEKACYFRSLCYFYYLLLFILIHGGSGGVGQAAIAIALSYDCEVFTTVGNAEKRAFLQKRFPQLKDKHFANSRNADFEIHVRRQTKGRGASVRCLAYHGRFLEIGKVDLSQNSPLGMAVFLKNVTFHGILVDAIMDPGVGNREDWKNVASFLQEGIKSGIVQPLSHTTFSSEKAEEAFRYMSAGKHIGKVLMEIRKEEPERVCIPSPIKVQAICRTLCHPHHVYLITGGIGGFGLELAQWLINRGARKLVLSSRSGIRTGYQARCVHFWRRTGISVLVSTLNISKPSDAQELVLQCQSMGVIGGVFHLAMVLRDCLFENQNVQNFKDAAEAKYYGTLNLDKATRDVCGKDLRWFVVFSSITSGRGNAGQTNYGWSNSTMERIIEHRREDGYSGIAIQWGAVGDVGVILENMGDNNTIVGGTLPQRMPSCLAALDLFLSWNHPVVASYIKADLGAKKTIGGGNLIQTIAHILGVNDISQLNPDANLGDLGLDSLMGVEIKQALERDYDIVLSMKDIRTLTLNKLQQMADTGGSPSTVLQTTELELKKEGEKEAEQNTVEQLERQMNQLFKMRVDVNDLEPMDLVLKCNKVDEGPPTFFVHSIEGIATPLKKVMSKFNFPAYCFQSTREVPQDSIEKVALKYISEMKTIQPKGPYRIVGYSYGACIGFEMATILQETDGDNSVEKLILLDGSHLYMQTYRNVYRMAFGVTGDTLVNNPLFESEIMCAMTLRFANVDYKKFRVELLQQPGFRARVQKVIDTVMTTGLFNSAETIDFACCAMRSKFVMADKYKPERKFRGHITLIRAEQGAAREEDVGHDYGISQVLPFNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHN6</accession>
    <name>A0A0N4UHN6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1601</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHN6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHN6"/>
    <dbReference type="WBParaSite" id="DME_0000707501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000707501-mRNA-1"/>
        <property type="gene ID" value="DME_0000707501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5816689at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000707501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9871" checksum="1FBE809AFAFFF18C" modified="2015-12-09" version="1">MSSRIKSMRVALRENLEKLKTPGKWEHITQQIGMFSYTGLTPEQVGHLIKEHKVFLLKDGRINICGLNPTNVAYVAQAIYDTVSNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHS1</accession>
    <name>A0A0N4UHS1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AIRC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9845</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHS1"/>
    <dbReference type="STRING" id="318479.A0A0N4UHS1"/>
    <dbReference type="WBParaSite" id="DME_0000711501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000711501-mRNA-1"/>
        <property type="gene ID" value="DME_0000711501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01416">
        <property type="entry name" value="SAICAR_synt_Ade5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000020">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050089">
        <property type="entry name" value="SAICAR_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599">
        <property type="entry name" value="MULTIFUNCTIONAL PROTEIN ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599:SF3">
        <property type="entry name" value="SI:DKEY-6E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="9">
        <location>
            <begin position="276"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000711501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47879" checksum="0C3A5593EF05833C" modified="2015-12-09" version="1">MSSNLKIKDWFENKNNLSLVAEGKTKKIWRSSLNDQNDFEKYVLLESKDQITAFNAQRCDIIHGKAKSANATTCNIFKYLHALGLETHFVETFNENSFIALNCVMVPLEWVARRIATGSFLKRNPGVPEGFVFSEPKIEIFYKDDANNDPQWSEEQILARKFIFNNILIGKNEIDLMKLQTDLVFRLLEKAWAYADCTLIDLKIEFGITSKGKIIVADVIDNDSWRVWPAGYRQFQLDKQFYRDLKVVDDTAINQLKENYNKVANITKEFNRDSIGQVVIVMGSSSDSNIAKSISEKLEYFGIKSVQRIASAHKTTLKVLDIIAEFERNSIPTVFIAVAGLSNGLGPVITGNTCHPVINVPNLNSEWGKSDLWSSLRMPSGMGCTTVLSSDEAAMAVARIFSLNDYMIYGRIAVKRYQNYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHV9</accession>
    <name>A0A0N4UHV9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9889</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHV9"/>
    <dbReference type="WBParaSite" id="DME_0000715901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000715901-mRNA-1"/>
        <property type="gene ID" value="DME_0000715901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079749" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000715901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="27517" checksum="34027881ECE35E6A" modified="2015-12-09" version="1">MALYVVLICFGLVQWIESGGVPLTECGSPAPIRPVPPPTACTDKDNVLCTAVFAPLGSDAAANANPANPFLVNPFCQNASLRANAVNLCPSSCAVCCLAPEFSCSNAAGADCTPFTTLPDLCTNPQTAPTALEKCPSTCGLCNRPGALGGCPNVATNCAQLLPLLTCTNAYMQANCMTTCNITTCISEVQLLSKACTGDPIGAATHMYRNHQNTLMISNLATTAAASSCMDTRANCAQMSSFCNISPYSTVMREQCRRTCGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UID9</accession>
    <name>A0A0N4UID9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1728</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UID9"/>
    <dbReference type="WBParaSite" id="DME_0000736601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000736601-mRNA-1"/>
        <property type="gene ID" value="DME_0000736601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000736601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7945" checksum="9C662C64FF3E07BF" modified="2015-12-09" version="1">MILASIPDSYFRPSKLRFVEVEADIGTGPEEGRGDTEIAGTGSDIEQTFITIVPPLTRLHNDARTSKKASIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIF6</accession>
    <name>A0A0N4UIF6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10027</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Dracunculus</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="WBParaSite" id="DME_0000738901-mRNA-1">
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        <property type="gene ID" value="DME_0000738901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820734at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000738901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34850" checksum="E3CA2A9E320BA164" modified="2015-12-09" version="1">MASDRAAWKRLTLIAVGASLTSNDGRLRISPDPARLAHYDYSFNNMTVVCSQQVDGKLQETDVVVNVDSLIGDDDNNGRYRMDDFESLPKNFKEIVHTRMNIKIGIGYGEWSCCTACCCTSETCSYEYALSSKECDKLESYRTRLAYLSFFKINPYREIKVAIARNIHIQQAIITFDKYLSTAPYHLTGIPIYSTLLRTDQNWKTLQRYLLAKLIKDKDYFKTIKGKLGQFVESESCNDMKEKFDCRILDEYLEYAVDAVFSAGSYKEMQIILNNVSATATRIGFDEVPDFKFLGSTLIPNGQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIR1</accession>
    <name>A0A0N4UIR1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10091</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDN60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIR1"/>
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        <property type="protein sequence ID" value="DME_0000750601-mRNA-1"/>
        <property type="gene ID" value="DME_0000750601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5838358at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052322">
        <property type="entry name" value="Mito_rRNA_Mtase_NSUN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955:SF3">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955">
        <property type="entry name" value="PROTEIN CBG01349-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
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        </location>
    </feature>
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            <begin position="55"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000750601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35720" checksum="482A40DF1ED41FD8" modified="2015-12-09" version="1">MSDYSFGMAQKVKDAIMVLLRVHVVQSAFWKMVVHLWNLCLNSATIITCTLQTLINSFLLLAFFTDNKLRSNSNLFLLISLTFTDLLYSVTELPYVIYMLCGWAAEGDIYHYNVKTMTYLGSIPMVFMKADIVLTTFIAVSRALALFFPLTYFRSNKKRIFILMLILTTSIAMFDIIVCYSFKKSRESYDCFSFGCCIGKIYRIYRGATNLIFHLFTCFITIAVIICPRKTVKVGDQRAQVRRKTEEANFRELDFIIRFCTSLNILAHSFIFAIAHKDLRKRLTEIFNSKSTTKIIRSSILPTNNSKAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ91</accession>
    <name>A0A0N4UJ91_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ91"/>
    <dbReference type="WBParaSite" id="DME_0000771201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000771201-mRNA-1"/>
        <property type="gene ID" value="DME_0000771201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000771201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13083" checksum="BDA1A33CFE9DE160" modified="2015-12-09" version="1">MVMSGGGEGAVDDDAWLLVLRWPLTSSSLRFSRFIRSSHFYIQKLFDAKDFTKDHSAVLLLRCVPFFRAKFMLSERNVLLFEFCGTLLKWLTRLSNFPRTASVQFVCADLFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ93</accession>
    <name>A0A0N4UJ93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1933</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51960.1"/>
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    <dbReference type="WBParaSite" id="DME_0000771501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000771501-mRNA-1"/>
        <property type="gene ID" value="DME_0000771501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000771501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8361" checksum="A53B21AF5B204C51" modified="2015-12-09" version="1">MTTYNRLNQEKSKEFALVKPEIKPKKTCQPKPKEDRDKYISAYSITESKAGGIIENLRAVVRSTGVMDRSSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ98</accession>
    <name>A0A0N4UJ98_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MAGE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1938</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ98"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ98"/>
    <dbReference type="WBParaSite" id="DME_0000772001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000772001-mRNA-1"/>
        <property type="gene ID" value="DME_0000772001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000772001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29321" checksum="9EA6DD3B933BB2B7" modified="2016-06-08" version="2">MSSTKSSTANLNLRRRQISNFLPQNYGKSEQSEETKGIIKDSDLRGIFPKTTSKDTRQRIMEQLIERLDSIFGIKLVSISNEQINYWIAKNNLSIDVGTFFSGNSFYSIEEEAKYGILISALMFLFMAKNPKLVNSTVTENALLSFLHKMGFDGNDISKKNIIDIAKLISPKPSAEFVSKGWISYEKLVDKNGVETVIYKWGPRAHAVINPLEILKLFCKIDKSELESWKNHYDLAMEWRNRRNESNLLRNSYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJK1</accession>
    <name>A0A0N4UJK1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4968 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1991</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJK1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJK1"/>
    <dbReference type="WBParaSite" id="DME_0000784001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000784001-mRNA-1"/>
        <property type="gene ID" value="DME_0000784001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000784001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7806" checksum="2C3ECB1918942996" modified="2015-12-09" version="1">MAYMIRDPVNNATFQSVPSRGFATSIRVHSRCYDAYLVIDGNVAYKFNDGTEATMEINPKDVLKTVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJM6</accession>
    <name>A0A0N4UJM6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Tu, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10219</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJM6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJM6"/>
    <dbReference type="WBParaSite" id="DME_0000787001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000787001-mRNA-1"/>
        <property type="gene ID" value="DME_0000787001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="42"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000787001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52704" checksum="682CA450D04C4067" modified="2015-12-09" version="1">MKFFNLLKFFGSLKFETRKKLILQNIRNLAMPATKEVYKRNKPHMNVGTIGHVDHGKTTLTSAITKVLSAKKLAKFMKYDDIDNIPQEKARGITIQAAHVEYETEKRHYAHIDCPGHLDYIKNMITGAAMMDGAILVVAATDGAMPQTREHLLLAKQVGIPVQNVAVYMNKIDEVPDAETQELVEMEMRELLHEFGYPGEDCPVIFGSALYALENKKPEIGEQSIHKLLKALDDVFVLPNRNVDTIAMFPAEKVYSIPGRGTVITGKLERGKLKKNDKVEILGNGKSPVKSTVKTVEQAEAGDQLGILLRGVDTKVVKRGNVYFLDKIYMYLLKPEEGGMNVPVANYFRKHIFSLTWDTSCRLKIKGKDFIMPGEAVEISLASTMYVEPQQRFTLREGSKTIGTGVITHLRPPLSDEEKEKRTLKKLMKVEIERLGFCPYGELIEKRLKPDYSHSPKDNPLAKVFEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKA0</accession>
    <name>A0A0N4UKA0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase A2</fullName>
            <ecNumber evidence="1">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10271</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKA0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKA0"/>
    <dbReference type="WBParaSite" id="DME_0000813501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000813501-mRNA-1"/>
        <property type="gene ID" value="DME_0000813501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021675at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="412"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="448"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="577"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000813501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="733" mass="81755" checksum="C090F5ED45E25C7C" modified="2015-12-09" version="1">MISGLFNTIKNAAAATEACRSVVEEVRNVITWNSSQPPEDRKICFLSTSQLSSLVKCDDFKSVSIYSNKEETLFYIVYVQRFVALSVMSNRNEALRKQKILNGLFRLIEILDVLEPNTFLNRVACLLISIEKNATYREIHHACSCGFDDVVENFCLNSSIDPIVVVNKATVDGLLPLQIAANNDNYNVVIKLLEYGADIHKLDLHMRNVFHYAAKKSPSILRLLMSYDRSQQAMNRFDSDGLSPLCLAMKSGHVECAKILLESGCSRGPFPAGPLCKIFLSVPVDTEGFINLLLKYEPNFLCEPICDGSSILHQDLDAPLLILIMSKVTKEVKDSEDKNKRTPLHRSVQRSNLSQTLALLSFEVNVDALDENGDTPLNIAVQIGSLELVKCLLCFGASVTLLNNGGLRPIDIAKKSSNAFRLGLKEILIHIEEKLGSSVIEYFDWLAGTSTGAIIALALARGDSPRSCQGLYIRLKSEVFIGEKPYSDKEFEQILKRYFGDSLVMAHIESKKIMITATSVKTNVPQLKLFRNYRLPLSEINNQVLGYDDPSNLLVWKCARYSSAAPTYFAPKDDYVDGGLVANNPTLDLLSDIHEYNATHAQANMEKADINCIVSLGTGVLPAKKIKLGKLEFGIPQNLEEGQSMLTDFLNMKSILIKQITASDGECVRRARSWAHGLNIPFFRLSPPLSTDVQLDEKENEIIIEFLWETERYLRTIAHSDIDSLVKLLKGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKQ3</accession>
    <name>A0A0N4UKQ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10347</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKQ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UKQ3"/>
    <dbReference type="WBParaSite" id="DME_0000833001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000833001-mRNA-1"/>
        <property type="gene ID" value="DME_0000833001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF443">
        <property type="entry name" value="ZINC FINGER PROTEIN CKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000833001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70462" checksum="D26826DCCABD8D52" modified="2015-12-09" version="1">MVKTMNIETKKMIENEAELIEEEEQKEYEEEEEEDEDELSEMMNISTNNSISRSTISSSTHMHDGETLNRLSDADELMIKSISETAHNNRPHSSWETNNSSFPIERRHICGICGKATLQVHERTHTGERPYKCKYCDKTFAQYGTKTVHEKSAHLGIRNYKCPKCSKCLSSPSALYTHKKTHGEKSLQCEFCPKTFTLKNYLKLHVKQVHEQNDRKHQCRYCNKSFAYAGSLQVHLRTHTGERPYVCKYCPKAFASQGNLQSHERTHTGERPYSCTQCGRSFIQKSQLTAHEATHQYQSSESSSETNQKKSNEYICKFCGKRYAYASSLYVHTRLHTGERPFRCSFCDKAFTNQGNMQVHQRVHTGEKPYKCNACDKSYAQKVGLKIHMEQCSQYLNGRLLSPEKESESASSIDTILPQLLGISNQGIVMSPLQYSSANPVCSAAEMNGSSVGIKLPTIPAKLSYSSPLISSGSSQNEYNCQISEIEPQKTSNADEKVLVPSKSIGQLNDLNFSAFRGITPDPFKNAMFDMNDPQLLLFKRIIDSGLSATMISQQILVHNQQLQFLLHSMKSSEPWRNLLSQQAPFIPAFPTPIPGAIISNASPTGVLQNGFTSPSVKQESPMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKR8</accession>
    <name>A0A0N4UKR8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2353</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000056">
        <property type="protein sequence ID" value="VDN52380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKR8"/>
    <dbReference type="WBParaSite" id="DME_0000834701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000834701-mRNA-1"/>
        <property type="gene ID" value="DME_0000834701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000834701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9468" checksum="81BF9BCDFC07465C" modified="2015-12-09" version="1">MKRFSKQMLYTRNDEGKTAEEEIKSLRYTSSESFSQCKLFQIRFYKSYIATVNSAMDDRLLGDNPTISEKAKKETEKISPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKS5</accession>
    <name>A0A0N4UKS5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2361</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000056">
        <property type="protein sequence ID" value="VDN52388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKS5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKS5"/>
    <dbReference type="WBParaSite" id="DME_0000835501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000835501-mRNA-1"/>
        <property type="gene ID" value="DME_0000835501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF27">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000835501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18916" checksum="5B58BB354A5E7B93" modified="2015-12-09" version="1">MDQNRNYFNFFDYFVDSIHDNLNFITIPNKNNNNHSATGDGGKPINCGCIIDTSTPETTAQGFNAWLKKNFMAEGLETKSSAILGMNSYGRPYCPGRPLSMKERNQIIELYNNGIKVNAISKQLCISHGCVSKIISRFRETGILYPTRISERKQSRKSRLYRCPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW2</accession>
    <name>A0A0N4UKW2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2404</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKW2"/>
    <dbReference type="WBParaSite" id="DME_0000839801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000839801-mRNA-1"/>
        <property type="gene ID" value="DME_0000839801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000839801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39999" checksum="952206A7991C1851" modified="2016-06-08" version="2">MASAKKRVEMALASKAKLQTAPHVQINTHVDDPQKSLEELFTAGVRTHEKKLYERRKNTPNSIPVSFNQRPVSIKSRGSSAGHSREGSSDDGIGSSGRQTLSPSSVSSAHFSGPYQGSVHTRQGSAPALINYGSVLEQQSNRPPPAPIHTTSKSLSVVTMSDASDQYLSTTHRAAKSCDLDAESNRHLEVGFTPEGQPFYIDHHQKITYWSDPRAKSQSLDPIALGINTNPVIQQQSLLPTPIQQNMCQDSDGNLGPLPDGWMKSYDHNGDLYFIDHINQTTTWYDPRIPHHLQEEKIRQRHGRPNIDQLKRTMFDNSQDTSSSLVQQLQIERRGMQERQEQLCREQQDLFCRSIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKY2</accession>
    <name>A0A0N4UKY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10367</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001213">
        <property type="protein sequence ID" value="VDN60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKY2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKY2"/>
    <dbReference type="WBParaSite" id="DME_0000842301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000842301-mRNA-1"/>
        <property type="gene ID" value="DME_0000842301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000842301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34385" checksum="4BCBE0DB440A596C" modified="2015-12-09" version="1">MSQEIIDNAEMNDINEAAETTKTTGKGNEDKKIFVGGIPFDVTNEGLAEHFSQFGEVAQAQIKIDRVTGRSRGFAFVEFATNEACKAALNAREQILGTKTVEVKPAKSRENKKVFVGGLPAETAEEELRKYFETFGKVEDIEWPFDRENKIRRNFAFIVFEEEDSADRASRNPKHTFGNRECDVKKAVPQGKRFAVGRGGNSMRGAYGLGRGIGVINGWYPHAAWSQINAFGAYGTTAGGWGDWYNNPATTGFYQQGAATGFTPYGLFKKLGAGGYETFPQAQTLTGQRIGNQQRVQQQQQQQPHQQPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL30</accession>
    <name>A0A0N4UL30_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS2456</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000062">
        <property type="protein sequence ID" value="VDN52483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL30"/>
    <dbReference type="STRING" id="318479.A0A0N4UL30"/>
    <dbReference type="WBParaSite" id="DME_0000848101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000848101-mRNA-1"/>
        <property type="gene ID" value="DME_0000848101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="217"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN52483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000848101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="50093" checksum="090EA5BC186C8F04" modified="2015-12-09" version="1">MESVKKYPINHRDLYTSILASVFRLRIGNRSFLLNPNEFFNREDQSRLVALAKADHHNRLKISDDYLSDTEEYYFERNTSVASPIIDYYITGILHTPLNICPIRFKEELDYWNIGLDQLCQNHPVIPFISELTKMGLIPGLYSKPTKYLNWYCLKFFITKFLGLVVGTMPEFQQDAHNASLYHLMHRYNQNGDTSSKFDSSDDFKKKFPSFIYRATDNPATFIVVIEYICMAWFTMDYLVRLAISPRKIHFFTDYLNMIDLSAIIPFYIEIFSKILGTEVENLKQIAGALLFAKIMRVLRIMRVFKLARYSSGLQIFGNTLLYSAPELTMLSMFLITGIIFFSTVMYMLEKDETDTYFNSIPAACWWCIVTMTTIGYGDTLPLTTAGKITAIAASISGIIVLAFPISMIVDKFAAAQEYVLIRQQFEMSGNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL58</accession>
    <name>A0A0N4UL58_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein lin-37 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2488</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL58"/>
    <dbReference type="STRING" id="318479.A0A0N4UL58"/>
    <dbReference type="WBParaSite" id="DME_0000851301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000851301-mRNA-1"/>
        <property type="gene ID" value="DME_0000851301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031523">
        <property type="term" value="C:Myb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336">
        <property type="entry name" value="LIN37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336:SF3">
        <property type="entry name" value="PROTEIN LIN-37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000851301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27400" checksum="E7AD7773C74F0A02" modified="2015-12-09" version="1">MPNTPPLDDGDDEAKESPDMKFARMRLQHLISRIRNGELRAQFPVSGSRPDNEAVNPVESRDVPRGPGRPKKPFQRERPIYNINFEYLGVVFELRGKPFALRSFSSNEAVYSLCRIWMRGKEDELLKESENEIDYPEPDDDSLELLATKEILAMPRPRENIRFSPFPEPIKKKTFSTIKPKDASVVLEDYLPHWRNVKNSWKNHREIRDRRYDKSIHLLNTVYNIAQQNTIHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM97</accession>
    <name>A0A0N4UM97_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2790</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM97"/>
    <dbReference type="STRING" id="318479.A0A0N4UM97"/>
    <dbReference type="WBParaSite" id="DME_0000896101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000896101-mRNA-1"/>
        <property type="gene ID" value="DME_0000896101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050778">
        <property type="term" value="P:positive regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010883">
        <property type="term" value="P:regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="103"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="103"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000896101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29363" checksum="1669C24B6CE342E9" modified="2015-12-09" version="1">MECDDIGPISRDRCNTWPLRRPQIDINPQTSPLIHERIPEEENDIYGSSENMSNSRLCSNVTVGMVASSGSNSGQLSAPNVDSSDTGSGISGSKKSTTRRNAWGNMSYADLITQAILSSPDKRLTLSQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFTRLQNEGAGKSSWWVINPDAKPGRSPRRPRSIMVISSQFFIFRPRELSRNLTPSTLSIPVSQSENFDDYEFPQFLDSGHIPSDLVDRTRQVMAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMD4</accession>
    <name>A0A0N4UMD4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2807</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMD4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMD4"/>
    <dbReference type="WBParaSite" id="DME_0000900401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000900401-mRNA-1"/>
        <property type="gene ID" value="DME_0000900401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF28">
        <property type="entry name" value="BAND 7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="102"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000900401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49792" checksum="5C04AC4CB22317F8" modified="2015-12-09" version="1">MNRIEYTALNEKKNDDDWKYKYKSAFTYADYNDIDKMGYEAPKRYPIQNGPRYKKYTYSNEAWEEQIEDRDKGNIFISLVELFFLMLSFTIFIFTLPLSLFFSLKFVSDCERLVVLRLGRAQKIRGPGATVIFPCIDKCTKIDLRVNAFNVPPIQVITIDRGLVELGATVFLQVKDALAAVCAVQERNQSTRILAITILYRITSKRQVNDIISGNGRKALSENLKDELGEITSSWGVEVIKIELSDIKVIKEGENMALNLFNKILKSEFGSQILGTLSKTAHEFIAEQQQQQQQYESKQEENPSEDLIQFSSTVPNNVEFKNTNKTEINIDELINYLSMIIDERLVTTIGQVFQIRCKDFGDFYLNLKNGSGKCMRGLYAGADVVFELNQETLRQIIKQKISPVQAYLNGSLKITTGSLKSASKFSVIFERIAHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMG2</accession>
    <name>A0A0N4UMG2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2825</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000082">
        <property type="protein sequence ID" value="VDN52852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMG2"/>
    <dbReference type="STRING" id="318479.A0A0N4UMG2"/>
    <dbReference type="WBParaSite" id="DME_0000903501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000903501-mRNA-1"/>
        <property type="gene ID" value="DME_0000903501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF34">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000903501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10741" checksum="BE88B00EBDE6B5AF" modified="2015-12-09" version="1">MILYSNCISYKDLYLNVTIRSSALEFYFQICFEIYTMDGRVPKLLSCGHTFCHQCIMSLNNDHIRARKCPTCRIPFFFLSESNFATNYSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMG8</accession>
    <name>A0A0N4UMG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Elongation factor 1-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2831</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000083">
        <property type="protein sequence ID" value="VDN52858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMG8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMG8"/>
    <dbReference type="WBParaSite" id="DME_0000904101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000904101-mRNA-1"/>
        <property type="gene ID" value="DME_0000904101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000904101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23664" checksum="C4CA4483842915A8" modified="2015-12-09" version="1">MFNIETENDLITLNGYLADNAFVTGFTLTGEDACLFSRFNSIPDGKKYAYIARWYKNIQSYSDDEKKLWPSATSSEEKKAENEDDFDLFGSDDEEEDDEKARITAERLKAYAEKKAGKPAGVAKSNIIFDVKPWDDTISLQDIETNVRSIEIDGLVWGTAKILPVAFGINKLQICCVVEDEKVSSDWLEEQITGFEDLVQSVDIVAFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMZ6</accession>
    <name>A0A0N4UMZ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2993</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000095">
        <property type="protein sequence ID" value="VDN53020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMZ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UMZ6"/>
    <dbReference type="WBParaSite" id="DME_0000925601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000925601-mRNA-1"/>
        <property type="gene ID" value="DME_0000925601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000029">
        <property type="entry name" value="Ubiquitin conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229933" evidence="5">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000925601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17971" checksum="2204B21B3FB9BF8A" modified="2015-12-09" version="1">MFYFSGFFAYLLCWLFLQELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPESPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKGDRERYNQLAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNZ7</accession>
    <name>A0A0N4UNZ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001239">
        <property type="protein sequence ID" value="VDN60742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNZ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UNZ7"/>
    <dbReference type="WBParaSite" id="DME_0000966301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000966301-mRNA-1"/>
        <property type="gene ID" value="DME_0000966301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057493">
        <property type="entry name" value="PH_RdRP-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25359">
        <property type="entry name" value="PH_met_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000966301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="57766" checksum="F7F8AFCE16D0C7F3" modified="2015-12-09" version="1">MAEKEQIEKIQELLPQFSYNKILCLLKEAGDVIERALDLINLNDSISKRQSPVFAYQTSDLSQNFYRITSNKMKIIVAEEGLPSEQIIFNITQTLSDCNCKIIQVKTLRYCLQAEYEEKFAELPVDIEFCDSFTAYKATIDFVRSFIQETGTAHDNVEFTSLAFGNMPNCGLFFLEGEYLAEKINLHDILDIGELSSWAHFEHNTRRILTFYFTIKNDTISKDDSQYVGFKLVWIVHCDSDSDEKSDYIFIHLKYPPQFLLKYASSLKEVLARSQYICFSLRKEAKQMLPNENFWINESNTNKHFTANTKKIGMYQICYKNAIISLQSTFQLFEILSGWKKRTKNRIVFGAVMKVPRREPKNRTSYEIGPFKNVCLHVKKALNATLATVNKRRQIALFNDTIPPNCVFIRKIIVTPLRILLFAPQISATKRIIRRFGEENALRCVFRDDNGKKLVESEFSCGRAQRDYFALAFLDSYSIKTLQFFGLVKLIGKRIAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP15</accession>
    <name>A0A0N4UP15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RAB2A, member RAS oncogene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3310</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000122">
        <property type="protein sequence ID" value="VDN53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP15"/>
    <dbReference type="STRING" id="318479.A0A0N4UP15"/>
    <dbReference type="WBParaSite" id="DME_0000968101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000968101-mRNA-1"/>
        <property type="gene ID" value="DME_0000968101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000263">
        <property type="entry name" value="Ras-related protein RABB1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000968101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21844" checksum="14CE4AB811C6B5BC" modified="2015-12-09" version="1">MDYFQIFCFINIGILGKSCLLLQFTDKRFQPVHDLTIGVEFGARMINIDSKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSNMVIMLIGNKSDLEARREVKKEEGEAFAHEHGLIFMETSAKTAANVEEKFIEKFRKANGIKLGPQHSPSSPNSPGGNPPLGGSGNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPI3</accession>
    <name>A0A0N4UPI3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3450</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Pseudopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000135">
        <property type="protein sequence ID" value="VDN53477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UPI3"/>
    <dbReference type="WBParaSite" id="DME_0000987301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000987301-mRNA-1"/>
        <property type="gene ID" value="DME_0000987301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918453at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051155">
        <property type="entry name" value="Nematode_MSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920:SF7">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000987301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14539" checksum="D52FDA6F974364DC" modified="2015-12-09" version="1">MAGSMPSLKDILTRPSSKIVFNAPFDEKHIYYIEIANMGTHRIAFAIKTTNLKRFDVKPCYGILNPKETTVLAVSCETFNPASENLCGERITVEWTKIPRDASQEFSTSWFRDDGAVCRKIMPVEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPL8</accession>
    <name>A0A0N4UPL8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000138">
        <property type="protein sequence ID" value="VDN53502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPL8"/>
    <dbReference type="STRING" id="318479.A0A0N4UPL8"/>
    <dbReference type="WBParaSite" id="DME_0000991001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000991001-mRNA-1"/>
        <property type="gene ID" value="DME_0000991001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000991001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18479" checksum="232AC986DAF4D64C" modified="2015-12-09" version="1">MTWERFFWAWHIVNTRSIFSAFDKPHASIDGEEGNSLAVIPFVDMFNHSNDCNAYACWDSIAQRYKIISCKLIANKKQIFLCYGAHSNDVLWMEYGFTLPNNICNKVNISHEVNNVESEISMKILKRLREHFKKKADCVPPKFQSLWIDQISIIEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPT8</accession>
    <name>A0A0N4UPT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3529</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000145">
        <property type="protein sequence ID" value="VDN53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPT8"/>
    <dbReference type="WBParaSite" id="DME_0000998901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000998901-mRNA-1"/>
        <property type="gene ID" value="DME_0000998901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861060at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000998901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13871" checksum="2996A6237771952D" modified="2015-12-09" version="1">MKIALCNKLTWLGDSRDQEGGIFMARLCHCTLGTADPCGNPESGLANSKIFAFGDAKFAVPDPLDSADDDACLYQSLRRSSDSAYLKPNRNCKVIWDSDSLILAKPFQRKIPYHPATQRIKHVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQD0</accession>
    <name>A0A0N4UQD0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3719</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000174">
        <property type="protein sequence ID" value="VDN53746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQD0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQD0"/>
    <dbReference type="WBParaSite" id="DME_0001021201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001021201-mRNA-1"/>
        <property type="gene ID" value="DME_0001021201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001021201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7191" checksum="27EA399A6503B835" modified="2015-12-09" version="1">MGPKKVAAYGAISNNVEDLRSQLASITEKYEKQQDLIMRLTRSVEILTKVNEELKDDIKLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQT9</accession>
    <name>A0A0N4UQT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10894</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001267">
        <property type="protein sequence ID" value="VDN60921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQT9"/>
    <dbReference type="STRING" id="318479.A0A0N4UQT9"/>
    <dbReference type="WBParaSite" id="DME_0001039501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001039501-mRNA-1"/>
        <property type="gene ID" value="DME_0001039501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230023" evidence="2">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001039501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23793" checksum="1540F2E4141F367A" modified="2015-12-09" version="1">MYFIYLPLLFFISNVTAGNNPINVCNKAVEVPQPPGGVGVQPQAPPQMRTIQRPTVDPNLCLDLNPQENLARLAEQLCPRTCATCCKTRKFNCRNVGQCDNVTQEMCKMPALSKIALEMCPHTCGLCDKPGAGGECPDTIDGCENLRIFCHIDSIRIMCQRTCFSKDCLQNLTSAVSQSSGCTDARVNCALYRNLCNIGDYGTVMRRQCRQTCGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQZ4</accession>
    <name>A0A0N4UQZ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3914</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000217">
        <property type="protein sequence ID" value="VDN53941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQZ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UQZ4"/>
    <dbReference type="WBParaSite" id="DME_0001046001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001046001-mRNA-1"/>
        <property type="gene ID" value="DME_0001046001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000007">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056456">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23335">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80 second beta-propeller" evidence="5">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80 second beta-propeller" evidence="5">
        <location>
            <begin position="374"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="6">
        <location>
            <begin position="576"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001046001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="721" mass="81736" checksum="79940B2775B9CC0D" modified="2015-12-09" version="1">MRLKIAMSRDPRHAEAVIGVGWINNDETVSCGDDRKLLRWNLLNAEAHMMTQLSGNFYPTSLNWFPRNQSKQPSDIFVITSTEGKFYLFNRSGKIEKSVEAHRGAALCARWSGEDGSVKMWSKNGMLRSVLSQNGTPVYCISWSGDSSHILYCCGQNCFIKVLKVQMSPIKWKAHDGVVLCVDWSCNSNLIITGGEDCKYKVWDNYGRPIFSSSSHCYPITSISWNVEGDLFIVGAYNMLRLCDKVGWSHSLENLNTGSILNISWSPDSTQFVGACANGHVVHCQIIERRVSWHNIEAIQSKRKIIDVRDVTSELGREKLEIKDRITKLALGFDHLVVTTTKQCYIFSIKNWNTPIITNLKECAVSLILPNVSKGDILYEKTVAVSNDTTAIRDRFDPKTIHIFETATARTAGDGKIVHSNDIVEIAIDQCGSADERKLAFIDTSCDCYIISVRSYSAKNRIAKLGTMITKICFNDTSNILAGLQDNQLIIWTYPGVVFVDRDLLPKIIINKECRDFGRSQQIISFIGNHISIRRSDGCLVPCGIPPFAVILISYIHSLKWDQAITLCRKMKEEHLWAILAAMAVDLNNFYAAEIAYAALDEVEKVNYLSSFRTLTSKEAKLAMMHGFKGNISKAESMFIQSGDFFKAIMLNISMFRWQRALELAIKYNMHLDTVIGYRQKFLQEFGRKETDKTFLQHLSEVEIDWECIQEKIRNEEQKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR08</accession>
    <name>A0A0N4UR08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3932</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000221">
        <property type="protein sequence ID" value="VDN53959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR08"/>
    <dbReference type="WBParaSite" id="DME_0001047401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047401-mRNA-1"/>
        <property type="gene ID" value="DME_0001047401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6020750at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9328" checksum="C86216C372B4EA4E" modified="2015-12-09" version="1">MVRTPNGKLFNRPIDLFYPLEVSEEGNEEARITTAAKDKLEEPIALRTGEAQRRLFNQVVKEKETKTITYYFSPILPIIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URI4</accession>
    <name>A0A0N4URI4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000277">
        <property type="protein sequence ID" value="VDN54107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URI4"/>
    <dbReference type="WBParaSite" id="DME_0001066601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001066601-mRNA-1"/>
        <property type="gene ID" value="DME_0001066601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039261" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001066601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16671" checksum="FB6FBADA1F44A040" modified="2015-12-09" version="1">MLRLVFFFISLIHVVNSGGVQIVTCAVTVGAVQRPSIHAHRCTNRDDRVCNEIFKNGANNGEIAATLAAQANPQVNYLVSDLCENPTLRNLALRECSSHCAFCCKTKQFDCPNAAGAEGACQRLYNEDNLCSDQRLNDIALEDVTHMWTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URL1</accession>
    <name>A0A0N4URL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SGNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4104</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000295">
        <property type="protein sequence ID" value="VDN54131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URL1"/>
    <dbReference type="WBParaSite" id="DME_0001069301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001069301-mRNA-1"/>
        <property type="gene ID" value="DME_0001069301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="2">
        <location>
            <begin position="84"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001069301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36345" checksum="0CAA1CC7E68C7801" modified="2015-12-09" version="1">MNDSFMATSRVKVNSTAVLSVSTTPVPHDGAKSFRIYLRNRLMIKRYYPIEPNDLHIYDDTFFDGLTSERNVPVHMVYVNGTGNTTAVLFGDSFAYTALYYIIQAFGPERLGHIKRCARYGCTPILSYSEDSSTSCNILAKSCLTVIHRMKPDIVFLNFQFEDAILSKIENITTDSIVKKLQKTIDELMLSTKRIVLTYDHPHSPFLAMANLALNNLVKLKSMDEFNIPYNLFWEKHRYGYERLDAIKCAKCERLFTYRWFCDTEISKTNCAMLIRNRRSAKNSNFRFVIHSTTKRSYCIIVIVVIWVYMESNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM3</accession>
    <name>A0A0N4URM3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10951</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001296">
        <property type="protein sequence ID" value="VDN60978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM3"/>
    <dbReference type="WBParaSite" id="DME_0001070501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001070501-mRNA-1"/>
        <property type="gene ID" value="DME_0001070501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851695at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040019" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001070501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="12988" checksum="90779640E28F25B6" modified="2015-12-09" version="1">MYVALIVFSFVQKIYPQVVNNPVIDQCFVEVPGQGGAAVPGGVPGGAVANVRRPSPLANVRRPSPLAHACSNNNDAFCAAVFDLTTAQDLQNNANPMMAYKVNENCQKSALRGEAIRTCPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2U6</accession>
    <name>A0A158Q2U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5216</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2U6"/>
    <dbReference type="WBParaSite" id="DME_0000085601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000085601-mRNA-1"/>
        <property type="gene ID" value="DME_0000085601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039161">
        <property type="entry name" value="C19orf47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359:SF1">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18017">
        <property type="entry name" value="SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000085601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14708" checksum="BA512514472DC792" modified="2016-06-08" version="1">MVIFLAMKWRNFFIGAGIPVAIATRYSKTFSEQRIHFSMLDEIDKNTLIQLGVTAIGDQVNDNSKIYRNVRYMYSKFSKFFKIIFPASPSNQSLAPDRDDIYHVRLPTGNTPKTKAIMKKHDMLRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q326</accession>
    <name>A0A158Q326_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5862</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q326"/>
    <dbReference type="STRING" id="318479.A0A158Q326"/>
    <dbReference type="WBParaSite" id="DME_0000150201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000150201-mRNA-1"/>
        <property type="gene ID" value="DME_0000150201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="13">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000150201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58385" checksum="7825E52D72993F4F" modified="2016-06-08" version="1">MAKCSNTIIARAFDEYHLRTCIRFAPRTLYDQDYLYIGKIDGCYSDVGRAGGRQEVSLDEGCLEYDTAIHELMHSVGFYHEHERWDRDNHITILWSNIDRDAYDQFGKTDFTKSSPYGQPYDYFSILHYDSFAFSKNGLETLVAKRPDMTRVMGKANDFSVIDIEKINRMYSCYQQPNNLQPQPLQPVKPWLVPRPFPQQPYLPPIQEIVDEVCEDQSSACHNWLDLCHSPIHEAEMRKICAKSCWFCASPVIDEIRPFSPINSPPTHYFLDRRNFWYCNREFEDEKILIQHQKAKHFKCHICHKKLFTGPGLAIHCVQVHKETIDKIPGAVPGKDSVEVEVYGMEGIPEDPADDEPGSKISKQDGTTNPVLPPPMPPFPMMPPVPPMMPGLPGFPPIPPVAMPPFPFIPPTAIPPRMMPPLPMMPPATPPVPTSIPIPRTTVPNSTVRPALPACPPATAPNVPAAFPAYSDPTTARLTEVKDSTTTVPKLCAKIHIMHPDENISLEERRAISRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3F8</accession>
    <name>A0A158Q3F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6672</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3F8"/>
    <dbReference type="STRING" id="318479.A0A158Q3F8"/>
    <dbReference type="WBParaSite" id="DME_0000231201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000231201-mRNA-1"/>
        <property type="gene ID" value="DME_0000231201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79830at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000231201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1102" mass="118555" checksum="9438B61B6741E9BF" modified="2016-06-08" version="1">MSKSKSNSWLSSVLNNLSGFWSNSPNDASQTPFSRISESSNSSKLKTELPLDTFRSTSSKFSHDSSSEEREFEPVIDCDIAPPSSGWDKIVKSESVRYLNPSLLRSSSLNEGSRQNERKRKYDTVSQNAGSERVFNDKNDSLIDSLLSKNVAKRSRFSEKCFPETIFATKQPDIIALNSSRISNRLSVSTVDYSSMRQVPAPKSSSSSLSNRTKAILEQLEKISTPVKEVRKMPIVRSTERWASDVINSPVQKPPRHSLCALSRAQMISDSLTVPGSPYWRRPFKSNRQENLEERMLDLDNSKHPIVKRIPGTRTIDIGDTINISFDNNIGAIPAVESCENDAGRPIPEKSEGIPEVRKNIFSTKLIDLDVDVDHVDECTSNGNQIDQSTRNSSLNGVAPAGFLNDIFTFAPPVQRGPSFVKKAMEIGNESKNAVSYEEKAVNASIENAFESFEKNSNVSTTIRKENTEQSNAAIPNDEKDCNISKPNFDINKDKSGTEKTENSYKEKEIVAVNVSTEEKSESGEKINITENSDNKKGTWYCNECFISNASEAVRCAACNSDRTGKKSITTLPNILANREFKPSAQINSGFSFGFQSSKGPVEDNLVVSSPFTTTTASNVTNGDVSSNQNISSNPVTTETTPCFNLKPAVSCPMFGIKDTKPNIIPVFGNSEKPTDSLSVESTNKIFTTHEVSQAEMTSGIFNFGNTVNTTNFSTNNQAGEKSASVIFGCDQSTGKVSSTVFGSKQESDNSALATQAPSIIGSSLFGINQSKKIVPAFGSEIPFSAADQSSLLGSFKSSGEKINSLVNAVQSTVTSVSNPSFSFFGSGPSTSTASSFIDSAASVLPSISQSVVKPDATVSNVSSTDKIGSSLFGNPQATSNKNLFSFGANNSDPSKGQSFIFGSKSNETNSQNNNSFSFGQPITNISNSFTNAASAVSSENSPMQVNSTPVEMVSPDGSSKSFNLGVTDAQQQSQFFTFGQVPTTSATLTGSLFGEQQAVNSSFPFANTMPSKVFSAPSLIPEQPSAFSFGASSANGSSGFAFGSPSQPPVFNFGGSNNTDAFQFRAAAPSANTLPSTNFFNVGPTSSTGSRKILRARRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3M6</accession>
    <name>A0A158Q3M6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VEFS-Box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7061</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3M6"/>
    <dbReference type="STRING" id="318479.A0A158Q3M6"/>
    <dbReference type="WBParaSite" id="DME_0000270101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000270101-mRNA-1"/>
        <property type="gene ID" value="DME_0000270101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21521">
        <property type="entry name" value="VEFS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="8">
        <location>
            <begin position="899"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000270101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1123" mass="129479" checksum="EF41BAB156E6B9E9" modified="2016-06-08" version="1">MEMRVRPARNVATRGNYTYRSRSAAQSSGEHIKTCRYETRHQSGCQMPTEKSRYSPEVAVPRSRRILKFSRNSTGSDCKNVALSLFVEKLDANALLADSDSSDPKKCRILDPNTSSATEIEIEKKNLHAVLLERCPIKAETNSLEYQLRKALRLYRYMSLPDIQSGYARPMYRPFLKRNLIYMKKSKFDSKYITDDILPPICPVFTREKRILSEGQKREHIHDIIAMIWRQKEENLNGLKRLSLISPKNTPQNNLKLLPTSRKELAFNGKSDLNKIANKQVEFSRSTPMIKFFDVRHKDMPGNRKALITVYLSTEIDGIFGEIVRLPSATVQMQINNRNVPVAIDLPRSIGCHLEHYMRERLILNDYVIIRVTFSGEDVRTPDGRTLRCVPSRKADKTDLKRTRYNSKISCARDNDGEDSVTMFGARCISSVTKHSAEDGVIYGNGSVILVSDSLLKLNGNWKRDTTLTKRLIELGKKLHMSPFVRMSIAQDTGADTSSSEDDDESKSCSSIVTSVASQAPQGYRSTSACYPKLLFNTNYFDEKQKNIRNLTTMEGPDQYMKSKHKFEMSLEFPKQICYRFIMKYNEEPDTVFPENHLPDVELSSCSTVMSISSAQNEELCEQQMKFVKNGRRHCSPLKEVSSAQIFNGHRQNNCYTSQPSCPIKQMDLTSRNFVSSQKQFNESIKVSVERNSIPLKSFSSARQFESPSNFRLVVPRRDLPLSTVIDQFATKYDKCSKIKPPKPIAADDKVTVPELHYAGFPEPDGNAMVTRFLSPPNKCFFCMGTFPDMFALLLHMRTSYPRLDIVYRGDARQTAVLNTSAPVYIDVFIRENFDCSFEGPMIRQYMSMRFRTSPSPQRCMPNDRITYLVYKAEARAIRGMKKDLSMFFTQSDREKRALKGNNAAFFGFRSRHPLMNCSQISTKQTDQEWLREYVIRQIEDFVDLSRLEKDFMILWNIFLLNLNHKPFGRCHVYRTCRLFIEKHRKDLIEKKLTMAWVSHLTTLHEKEALDSDEVYDLTLRLKENYDPTEDHRHVVYNTRLKLENMANNIKKEPPAWQKDPIHGPKVSILRSSSVARFSTAEQNPENEPVGGHRRQREPDCSKYLFSPRATKVPRWLSFAEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3T1</accession>
    <name>A0A158Q3T1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7274</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3T1"/>
    <dbReference type="STRING" id="318479.A0A158Q3T1"/>
    <dbReference type="WBParaSite" id="DME_0000311501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000311501-mRNA-1"/>
        <property type="gene ID" value="DME_0000311501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857016at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF145">
        <property type="entry name" value="PROTEIN CBG15266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250694" evidence="2">
        <location>
            <begin position="18"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="3">
        <location>
            <begin position="268"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000311501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65208" checksum="812CCEB528662378" modified="2016-06-08" version="1">MISYLFVLLVALATLDAQLIALQAKFNNASIKFLNNIMNNLLKNEVSKVVIPDYTIPVSMALGSGQIKMKGLKIANFQESHFFLRPHPSGILLEHNSNAPDIIEIAGNYELYYKILFHETKDKGTMNFKISNITLSMLYTFAKRNNKPEIAIAQCKVKANVTYDIAFNSFVLKVAAAVARSSIDNIINEQKAHICYYLKLFLKNVVNARLQTMPRRMELADNIFIHYSFPRFPIIPKTDSIGVMLYANVTYGKEPCPSAKSVKYPEMTNNNSMVQIRFSVHLLQCLASSIHKGGIIEGKISAKDEKLLAFFLTTSCRRICIGKLFTKLEEKHPNSGVDLYIKFAKKPLIEMEEAGINISASFLVDLHLTSIDKNKEKFATIELNISAKLLPKIKGNILFGQLNGFVLSVKQIKSSVGEIDQKFLQYIQKNFLEKIILTAVKARLKAGLAIPSIYNISINITKFIMKNGYMQVDVNLKNINEKENEKGIIDDKKKIYLEKEEENGDEEKHKKNKTKKNKKDKNKKKKNNESDEDSEDDNDKDDDDDNDKKKKTRRKETFTLKKKFKIKFENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3T6</accession>
    <name>A0A158Q3T6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7295</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3T6"/>
    <dbReference type="STRING" id="318479.A0A158Q3T6"/>
    <dbReference type="WBParaSite" id="DME_0000313601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000313601-mRNA-1"/>
        <property type="gene ID" value="DME_0000313601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000313601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50294" checksum="C405A84AC9AAE8B3" modified="2016-06-08" version="1">MDDSEKNSDEDAMEVEDSVSDAKKTTKSKKPKEKINRIELIKCCTFQVYVPGVSRALKSGEEWEYDPEAYRIFHKFESDWPCLSFDIINSVDKDDSSMTLSLIAGSQADSRNIRNNQLYVMKLVGITPIVEELDDSDDDYDENRRSPVMHCVSIRHHGEVNRIKATNLGQSTVCAVWNSFNKVQLWNATNALNCINNLDSDAKILRKSLDEKPLMSFESSIDGYGISWSSLKTGRLASGDKHGKIFIWTMAEGGTWTVDQRPLVGHKGSIEDLMWSPTEEPLLASCSVDSTIKLWDIRVARKEACVCTVSNAHASDVNVLSWNKYEPLLLTGGDDAVLNIWSLKTIQYNEAVARFKHHKQPITSVEWSPHDSTTMVASSEDDQITIWDLSVEQDESENLKGVPPQLLFIHMGQNEIKEVHWHNRYKGLLVTTAVTGFDVFQPCNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q471</accession>
    <name>A0A158Q471_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8038</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q471"/>
    <dbReference type="STRING" id="318479.A0A158Q471"/>
    <dbReference type="WBParaSite" id="DME_0000415501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000415501-mRNA-1"/>
        <property type="gene ID" value="DME_0000415501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000415501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34967" checksum="5ABF6B5075275366" modified="2016-06-08" version="1">MPLRYLVPLALRTSGANTIKEQGSDCSPVKLISYTIFDLKNISKKSVVEEIHVNVNGLQLALDKIENFIPDGSLLVTYGITAIRQVIHPLALRNSINLGEIFYKFFNIAQFDDIFIKPLMPSSTTTNDCCNNLNEEICAICERLCDLVTNGYLSEDSFDLNKANHLIKEKFIKGENVNELRPYIDEVRVELQNGLCETEVDPSVIVRARGLPWQATDLDVAQFFIGLNIAPGGVALCLSAEGRRNGEALVRFETNEQRELALKRNRHFLNNRYIEVYRATKEDFLQVIASSSSLVPLLVISDFTDSASYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4D1</accession>
    <name>A0A158Q4D1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P4Hc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8486</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4D1"/>
    <dbReference type="STRING" id="318479.A0A158Q4D1"/>
    <dbReference type="WBParaSite" id="DME_0000460301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000460301-mRNA-1"/>
        <property type="gene ID" value="DME_0000460301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="4">
        <location>
            <begin position="41"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000460301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27553" checksum="8ED558D705FF403E" modified="2016-06-08" version="1">MCSQLAVRSFTELEPSINPNYLSDSYAYHFQQTLKDSKPFPHFSLTNFIDNEEFVQMVRSELLNMEYSLVTTDLYSNYQTFDIESSPPPYLPSIVKLRDFFKTKVREWLSSISGVELTTRVSIVSTIYEHTQILLPHDDQLDNRAFAYVYYLTPQWKPNYGGELALFDNVNNYPRREPLSNSLALFRVSPASWHMVKEKCDFFRLSVHGWFYEPKVTSILRLPPPARNPLLNSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q591</accession>
    <name>A0A158Q591_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NUDE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1436</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q591"/>
    <dbReference type="STRING" id="318479.A0A158Q591"/>
    <dbReference type="WBParaSite" id="DME_0000682201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000682201-mRNA-1"/>
        <property type="gene ID" value="DME_0000682201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="136"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000682201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="34502" checksum="B99560A03CD729E0" modified="2016-06-08" version="1">MRLEHMKIDLFRHPFPLSLVINGEWCLWQRAEEAKADLRDFVSYSQQIEAELDKELNEAREIIKRKDYEILVLIQERDKLKNEASRLKVESFGIERKMGDELTRLQSENERLIKEVRILEQRNDDLERELRITAESLKDTEKMLNDELEVRALLTTELESKDELKDQCQRLEDEIRDLKLDISVKDAKILSRRLSEKFTLHNQPADTENFRIRKGYVDSDRINHTYDMQRRKRLSTDTEIVGSRVNALPSPLARNVSPVINNLLKTIQALEDKLIMLQPARRAYENGFNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5C1</accession>
    <name>A0A158Q5C1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS1549</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5C1"/>
    <dbReference type="STRING" id="318479.A0A158Q5C1"/>
    <dbReference type="WBParaSite" id="DME_0000697001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000697001-mRNA-1"/>
        <property type="gene ID" value="DME_0000697001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000008">
        <property type="entry name" value="dynamin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="17">
        <location>
            <begin position="30"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="521"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="16">
        <location>
            <begin position="657"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN51576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000697001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="828" mass="93662" checksum="AF3506ADC3A42E8A" modified="2016-06-08" version="1">MSWANTGMQALIPIVNRLQDTFAQLGTSLNFDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLVYSSRAEYGEFLHKRGQKFTDFDLVRKEIEDETDRLTGANKGISPIPINLRIFSPNVLNLTLIDLPGLTKVPVGDQPADIEAQIREMILTYISRETCLILAVTPANSDLATSDALKLAKEVDPQGLRTIGVLTKLDLMDEGTDARDILENRVFALRRGYIGVVNRGQKDIVGKKDIRVALDAERKFFISHPAYRHMADRLGTPYLQKVLNQQLTNHIKDTLPALRDSLQKKMFALEKDVSEYKNFQPNDPSRKTKALMQMVQQFTMDVERSIEGSSAKTVSTNELSGGARINRIYHERFPFEIVKMEIDEKEMRREIQIAIRNIHGLRVGLFTPDMAFEAIVKKQIERLKEPSLKCVDLVVNELAVVIRQCAECTARYPRLRDEIERIVTTNMREKEQVAKYQISMLVDYERAYMDINHEDFIGFSKQVAEAKASSSQAKKNLGNQVIRKGWLSVHNISFVRGSKDCWFVLTSDSLSWFKDDEEKEKKYMLPLDGIKLRDLEAGFMSRQHKFALFYPDGKNIYKDYKQLELSATNLDEVDAWKASFLRAGVYPEKEKPVEESENGREFEETTSVDPQLERQVETIRNLVDSYMRIVTKTIRSTVPKAITFLIVNKVGEFLRDGDLLASLYQLGDTDSLMEESQLEAQKREEIIRMYHTCKEALRIIGEVNMSTPIDGPSPVYNDFIRSEGASPVPRSAPQPPGINQRMAPMPPRPMNAAQNMPPIANRPLPGPPGGLPAPILPMLVAFNCSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5D4</accession>
    <name>A0A158Q5D4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1607</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5D4"/>
    <dbReference type="STRING" id="318479.A0A158Q5D4"/>
    <dbReference type="ESTHER" id="drame-a0a158q5d4">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="WBParaSite" id="DME_0000708101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000708101-mRNA-1"/>
        <property type="gene ID" value="DME_0000708101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="9"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000708101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55699" checksum="97F516E0F3DEFCFF" modified="2016-06-08" version="1">MVSLHDGSPIVGHEAFSANGRLVTEFLGIPFAEPPVGELRFRKPKPKAPWRKLFNATTLPNSCVQSLDSYFGDFDGATMWNSNVPSSEDCLYLNIFIPGKIDPAAKLPVLLWVYGGGFWSGCATLEIYDGKIFASEENVIIVSMNYRVSVFGFLYMAREEAPGNMGLWDQLMALKWVHKNIDLFGGDPNRITLFGESAGAAAVSMHLLSPKSTPYFQQAIVQSGSATAPWALEQRKVAIARSVALYEDMKCGNMSKDPEKWDLNKVLQCLLDAPAELIRDSEWAPVMEFVDFPWVPVIDGDFLIEQPSTALKQGNFKKTQLLAGSNLDESIYFIVYQLGDIFPPNDFFTKNDFITNRSTWLRSISNLLPRSYMKSQLGLASIIHEYEPAELPVKPNDWIDSLDKMLGDMHFTCNVNELALANNIHGGDSYYYYFTHRSSQQTWPSWMGVLHGYEINFIFGEPLNSQKYKYTQEEKELSRRFMRYWANFARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5K2</accession>
    <name>A0A158Q5K2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1882</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000035">
        <property type="protein sequence ID" value="VDN51909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5K2"/>
    <dbReference type="WBParaSite" id="DME_0000761501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000761501-mRNA-1"/>
        <property type="gene ID" value="DME_0000761501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5785977at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBXO47 ARM repeats region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000761501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="62113" checksum="F0BA363BD62C784F" modified="2016-06-08" version="1">MNLRCRRKFWVVNGSFGIFGQYDLSSHMERICPLSVNNNHAVESQRRYNLRSSNSSSQQTIQPKNSSRILDYFVLRKRSISSMDKHKNIQSLRKKFKHDLNFNLSESLQVVPSLSHTTNYSESQIVPSNPVNPLGIFAVLPYELLPTFFDLIPIFCVVNLSLLSKELNKLVCSYVFSKNAKGRFANESRKQVTHEDERTNEDPFHTWGLLLKAVTSIFQLSARKIFLGQFFDENKTNIVYLFCSQWSYFECNELLRCILKFNGNFLAKSMGRVLNSKFGEFSDLELLVRRYLRGYFLDHDHDDFSFWLSAILRTQQSVAKQGRLFMILYCPTIHQNGKEKIDWFLFANTTFRTFSESLLKIGSLSFCLSRLQLTRFIGFDQFVWSHYDLFNLIEEITTIAELWSLDNFASLLVHRPGLIPIAFTIRIIYGRVQEVGELFATMKTVGILCNVRIFFENECMALELNDNLQLLYRWDIDAANLLLSPLLLTIRPLSAEHKRSFLSSFYLSEAEQLKSHLTSIPCKFLLFFCEQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6E5</accession>
    <name>A0A158Q6E5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10781</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001247">
        <property type="protein sequence ID" value="VDN60808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6E5"/>
    <dbReference type="STRING" id="318479.A0A158Q6E5"/>
    <dbReference type="WBParaSite" id="DME_0000987001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000987001-mRNA-1"/>
        <property type="gene ID" value="DME_0000987001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="158"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000987001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32673" checksum="AAF5CD1AC650D708" modified="2016-06-08" version="1">MAESAVEFLARRALKPDLYRRRGSVIVHESTAGCTAVARIKLFFSYDFTKSDFLVSITEVKDAMPLDEFYFVLTLEGCNQRESEKILAGTIFNQQSFKFALPYEELLERMLTVQMIGAVKSGSSVIEVGQKDIDLSAIDPSDDVILWTTIEANNSQESCGELLIGMQYLLAVERLTVTIHSARGLKCSLSDGCVRIRLLYAGKIQKKRKSSFKKSDNCPVWDEAFHFRIPQIALSSSQIEITVMNYDRIGKHTAIAMVIIDKQHPSKIWKQMLDNKKVNPRWIPLQTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P8P1</accession>
    <name>A0A3P7P8P1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P8P1"/>
    <dbReference type="STRING" id="318479.A0A3P7P8P1"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="12">
        <location>
            <begin position="669"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="1408" mass="159833" checksum="78A849155CA480D9" modified="2019-02-13" version="1">MLKRAASEKKKIYKLKMATNGGSLEDCYTNVFAVTELNGLRWKCLTTPVPSQRTWTSIEQDPVLMAYSKCLQAGILCAWRRQPPSSTTTNNPLLIPDYRIDVVKELWVFWYSQEEPELLSQFTSNENSHGNWSVPGIQYEIRTLFFKAFHNLYERQLNRNGYVRIGRYFTRPYDVPSADRIQCSPGYILGINFNFFVHGENTMCTSVNFQRQPTLFRLSRRHLDNGKRQPIILAPWSLRATLLPDQPKTFDDLIVRRVYTGETGFLFSVAKNGENAVPTMVLVDVDGVRLWYPIIFLYCLLTNEKVINLCIFKDMSKFDPKHTNIIYNFCCNFFSRSNTLSQVIENNSSAAVRIHPEGKSLVLAVLLQDTVLDLHYDTVFDSCPICSCNGNIRAKEFGMYITPPEILRQPLSQQQLVVNKPTSGFYNNGAANTCTCGFSAVRHRYLSMKAGLFAEDAKEATDITESPNQPVIPHAIWFDPMSGSPQFQFERIGSDMSKHGEYIISEVDQRELPLVFQAACEIACMEMNSHPPPRDVRSVLLHDWGIQIANEMREPRESECLAALREIAPILEGALRIARSASQYSNNNIVEGPLTWRLFDRKSLKSCGGMFYEIPILSDYFDLKFKDEDGCPEPVPNIMVASEKDAITASPQILRMWEKFALEPYDQTKDVLYIGVVPDSIVCIERSKKYFEDLSRMYEQCRLGRHIPFAKESLKDGILRVSMRYPSTNPGDCDNFLNQVERHIGDNKSLIARLKIYKQCFENEVARILLNNDCIFNRETYRTLLLENQVKYSFQDMYSEKFGQFFQCPNSVGASCSIIGCIGEPLTPDNLTAGDNSSQVPSSSTSLLNEQVLDGVVPDDEPGTLPHVIVLYVINPFLIGVEDNSLVARVVTVALMRSFSALLYRLNTRRRPQLQLEIIGLQTIFDYTAVTSDFLKDDFGRLNAFDQEKSINERLSSVDALKTTAFSVYTQSRIVLPEVVRDILPKSMTRFGPSAAMGDLLSELDKKEPIFYKQLQFKVPSKAFILAPPQPVMLRPSGDLMQINTDETILFVSYCLVGNDWLAATVTDHQGHLLDNCLINLRVNMRYKQSTQIRDSLYRLWSYILGTLATGTKNWRLVIGRLGRIGHGEFKFWTQLLNKSYLKQVGSRMKHACRSCHMISNILETPGILSACLVSLEPEPYIRIFPSSFQHDERFSKSARYRTLTTPDDSSCTHILVFPTSPEINVYDDFSNLLTTDISIIGDDFSDLIVDGEDLMTNPTGPPPNSATFRISSNTGIPNEYGEMSIENQPLATGYYISTAPASDLPDWFWSSCPFVKRRNPVHLKCSLHLNTPNVQQGDDISSFGAKEACHHQLDSQATADVLRYVLETYNALSWLNIDYVTGERRSCLPIHIQALNRLCNTVNRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PRJ2</accession>
    <name>A0A3P7PRJ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000104">
        <property type="protein sequence ID" value="VDN53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PRJ2"/>
    <dbReference type="STRING" id="318479.A0A3P7PRJ2"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF3">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="152" mass="17760" checksum="C4D723D407AD1C63" modified="2019-02-13" version="1">MMEWIQSSTLPNSSWTGSMQLMAGIKACTGRRLANHPHFEDKWLRDRTRRVYQVYGRKSMHEVNKILQNENIDYIILEDSICLAPSTGCSTNDIIDITNGEKIDSDLSEADWLAGNEIRFCERVRYQDEEARKYFILVFVNRTFRVYSVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXR4</accession>
    <name>A0A3P7PXR4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXR4"/>
    <dbReference type="STRING" id="318479.A0A3P7PXR4"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="404" mass="45081" checksum="995796114BD6F0DF" modified="2019-02-13" version="1">MLPAALPFLQTFFNNSGNNADQLWEWLVSMRKYGLALGSLASIYISIICGRKWPITIGMIIQLIGGVMCLFIKLGYCGIVAAFIGRFLNGFGSAILQTIGVSMMSEIPSVYCRGRVLASNVLWACAGELFGFFIGTDYALGTEQLWPIALFAPLALLPCCVIILYISAESPRFFILRDKIKEAKQSLKFYQVNLFRISIIPHKNPTKLILTRFSSGTFLKPLLIALFTQCFVHIDDWLWITYSTQAFINFGYDARTSQITTLLMAIPAVFISISLVFYFESFTRRSLLIAPTIGSILCSLLQKIKKIAIPILASIDLCMAALASESAYTVVPELFRLSDRTFGISLVIFLQNVYGGLLTTVILSIMNSNGLEYILIPLIVNNYCYILGIYFFLPETSGKTFKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q543</accession>
    <name>A0A3P7Q543_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q543"/>
    <dbReference type="STRING" id="318479.A0A3P7Q543"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22042">
        <property type="entry name" value="HMG-box_EGL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000003">
        <property type="entry name" value="Putative transcription factor SOX-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="76"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="76"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="228" mass="25703" checksum="C17133E3EAB169C3" modified="2019-02-13" version="1">MAHRSTNGIPSSALSQNFPLNVTPLRFLKKLISIVFFLASAFTSHSPASSDKTSPGAGISNDNGSLRLTAKSPNHIKRPMNAFMVWARDERRKILKSCPDMHNSNISKILGSRWKAMSNTEKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCLVDGKKVRINEYKNLMKNRGRAGGGGDCVGYNNTVGLDKSIPTTTNNDRSNLFVPNLLTDLSSHHHPYHILQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QPG8</accession>
    <name>A0A3P7QPG8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 39A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QPG8"/>
    <dbReference type="STRING" id="318479.A0A3P7QPG8"/>
    <dbReference type="OrthoDB" id="5862608at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF4">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54662" checksum="925A25FB50046D00" modified="2019-02-13" version="1">MPSLIPSPPLLSTECAGVTVQIHPIWPEMPQGQGELFFECTLFLYSVLALFLQYLNLYKTLWWLPKSYWHYSLKFHLINPYLLSCVGLLLGLRVTKCFWNTITEFVSTSSLGVTGIQLVVWKIVEWGIVKTPMFFMVASSFLFSFSRVYHDFPFKSLLYFGHPFLFFVLLYFQDIVYKLQRMVSVVYFVVTGGDIVQSATAPSLYPSIQVPPSLVDVEDVVHMCSSNSAQIREEVGILIRDFNLRIKHCLFSGLSTAYLSICVPCVFTPQKSPSGIPQQMWIDGVWVCELFIVVFLTSFSLYVTYLFPIQYCDLLHRSASHLGHWEKIEKCPATSTNALSSSANIYPPTWSELDGLYADGTIVRHKGNFYRAYATSGTSGVAAEPGEIDHCRFYRMAIDPVTIVNGMCIFQIFLIIMQFWMLVLTTDWQHIVTLVLLMFANYLLLAKVFKDRVVIGRIYNPSPEDLHLIKQMRQDTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QTL9</accession>
    <name>A0A3P7QTL9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QTL9"/>
    <dbReference type="STRING" id="318479.A0A3P7QTL9"/>
    <dbReference type="OrthoDB" id="5794438at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="273" mass="31784" checksum="FF77CD4114087B28" modified="2019-02-13" version="1">MPDWMLIRMASSISIKLGPSVGKQLLIKYRGERRDDCYPRNATVTDQQICVDIARILGNNPSRYNAAKQFYLMLNEMHFCKPKSDALNVLFGFWVKKNNIEKAVDELEDLLHRLKFKSIGSILFVVMSLICSRDSLVMKYAKTRLQRICIIGCVLLDQNLPIRFAELLHKEEFLLCFEAVRFICSVAASKRRPDMLFNLLDCHELFKLDNKARNYICNALVVIYGKKREIDGLNKIWHSVNNEKNLDDFLSTMNALKHFYKCLRVHCPKIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QWA6</accession>
    <name>A0A3P7QWA6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QWA6"/>
    <dbReference type="STRING" id="318479.A0A3P7QWA6"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="93" mass="10568" checksum="D60F6928A58C93AD" modified="2019-02-13" version="1">MMLAKEIFNVHPDQCIAVHCVAGLGRAPVLVALALMEAGMKYEDAVDLIRRHRRGALNQKQLTFLEKYKPTGRLRKLRCKVDDDKNNKTCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N9</accession>
    <name>A0A0N4U0N9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4485</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N9"/>
    <dbReference type="STRING" id="318479.A0A0N4U0N9"/>
    <dbReference type="WBParaSite" id="DME_0000012501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000012501-mRNA-1"/>
        <property type="gene ID" value="DME_0000012501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000012501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40909" checksum="9E2F00C71CCA54BF" modified="2015-12-09" version="1">SFAFRILKQVTEATDNHLPIWAILVAGSNEWDNYRHQADLCRAYHLLKDHGVRPENIITMMFDDIANNTNNPYPGKIFNEPNGPDVYAGVPIDYKGKDVNPANFLAIITGNKSAVSGGNGRVLESNATENVFINFVDHGSTGLIAFPHGITAKDLNNALKEMFDNQMYRNLVFYMEACESGSMFENILQNDTNVYVVTAANASESSYAYYCDNNMDLPCLGDLFSVMWMEDTETSLYQQFKIVKKETNLSHVMHYGDQKISQEPVGEYQGWMNPHQLRKKKVRIVQFFIKRLYLNQFMNDFILTLDSSSADRLLKKNSFPIIDFDCHDTVVKAFHEYCFNFGAVSSHLQLYNCIICIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Z5</accession>
    <name>A0A0N4U0Z5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4604</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Z5"/>
    <dbReference type="WBParaSite" id="DME_0000024401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000024401-mRNA-1"/>
        <property type="gene ID" value="DME_0000024401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000024401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9026" checksum="FB0FD8358A0A8610" modified="2015-12-09" version="1">MLGHRESGNRRKRFPAVHLSSSNSATMASSSSSSAINRATNPPNSVEQSENSCLSEIRSHTSIWHNDFHNLSQDIFDDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1T9</accession>
    <name>A0A0N4U1T9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4956</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1T9"/>
    <dbReference type="STRING" id="318479.A0A0N4U1T9"/>
    <dbReference type="WBParaSite" id="DME_0000059601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000059601-mRNA-1"/>
        <property type="gene ID" value="DME_0000059601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008716">
        <property type="entry name" value="DUF1782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR008716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR008716-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000059601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18935" checksum="2206BF2BA0E0C1A3" modified="2015-12-09" version="1">MSDLDESAKTTLKAIPLLKTKAGPRDGDLWIQRLKEEYEALIAFININKANDSDWFRLESNNDGTRWFGKCWYYHEMVRYEFEVDFDIPVLYPTTAPEIAIPELDGKTAKMYRGGKICLSDHFKPLWARNVPKFGIAHAFSLGLAPWLAVEVPDLVNRGVIMPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1U2</accession>
    <name>A0A0N4U1U2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit dss-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4961</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1U2"/>
    <dbReference type="STRING" id="318479.A0A0N4U1U2"/>
    <dbReference type="WBParaSite" id="DME_0000060101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000060101-mRNA-1"/>
        <property type="gene ID" value="DME_0000060101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000060101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9619" checksum="80F88F347D259D65" modified="2015-12-09" version="1">MADEKKDSAVEDTKKMEIDTVEEDDEFEEFPLQDWQAKESNDEEEELNVWEDNWDDEVHENDFSKQLREELTRNEFTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2S9</accession>
    <name>A0A0N4U2S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mesoderm development candidate 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5365</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2S9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2S9"/>
    <dbReference type="WBParaSite" id="DME_0000100501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000100501-mRNA-1"/>
        <property type="gene ID" value="DME_0000100501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75833at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019330">
        <property type="entry name" value="MESD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600:SF2">
        <property type="entry name" value="LRP CHAPERONE MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600">
        <property type="entry name" value="MESODERM DEVELOPMENT CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10185">
        <property type="entry name" value="Mesd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000100501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19959" checksum="CE95971ED3F55841" modified="2015-12-09" version="1">MVTATVTHFLFQSILDYNEADLERIYEEWEENDEDVLEDDEKPYHKRPQRPVDIDELRKKVTSPEDFLRQSKKGQTVMMFVTVGDVDDKPAPKNYTEHYTRLWNRSLNNAHIEAQVFVIEDNRAIFTFQDGSDAWEAKDFLLKQEEVSNILLEGQSYNGKAKRNSPKTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2V4</accession>
    <name>A0A0N4U2V4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PA2c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5392</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2V4"/>
    <dbReference type="STRING" id="318479.A0A0N4U2V4"/>
    <dbReference type="WBParaSite" id="DME_0000103201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000103201-mRNA-1"/>
        <property type="gene ID" value="DME_0000103201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839847at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF107">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000103201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21779" checksum="B3494DA6F71E5B49" modified="2015-12-09" version="1">MGSEATKDRGMRVRFALRWAVLPSFIKMVQISIIPIILYLFTFCNTRSINSLWNLEEICYCRLGYGAFVYNDYGCWCGIGGSGKPMDGIDRCCMLHDLCYDAAINQKICPFVIWEYMDNYQWKCENHQPVCLDRTEDDCKSAMCECDKMVVECWGQFDKPKIKAECEKSNETKFKLRNSTYTKWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2W3</accession>
    <name>A0A0N4U2W3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5403</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2W3"/>
    <dbReference type="WBParaSite" id="DME_0000104301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000104301-mRNA-1"/>
        <property type="gene ID" value="DME_0000104301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836963at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF10">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000104301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="47388" checksum="268C16423C85C6B7" modified="2015-12-09" version="1">MTILNGTGNVTNLSELNHHLLWKLIPIKLYRWWCYWIYLFWFVMGILVLRKTRNAVAAVSYVKMHGHTVSDEAIMKSSAFSNLLWSLEHKFEKPPAIFFLNQYALNMTFNFLCNTRYMQNAHERFIFVTLDDVARDVLREYWPNVEQIYWPTPSLYRPFSFAEGAYQTLYLLRANLAVSLLKHGKSFWMMQQDTFWRKNLFELNLEENKDFDALFDQIGDDQNSERAEWVNGANFFVHANNDTLKFFEAIARKLAHWYTPDMGIMIHQCHTWDKPKCQYIPHKTAHSWEWLYTDQKDPPYILQLDCETDGGSKLMQLAKFGFYFVENDNHRLCNATAVEVMQKRMDEGKIEVSRAKLSWGRFQFKAYWWIVDNMLSTPYIGPIMKPYLPLIGFFLLITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3A8</accession>
    <name>A0A0N4U3A8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5567</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3A8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3A8"/>
    <dbReference type="WBParaSite" id="DME_0000120701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000120701-mRNA-1"/>
        <property type="gene ID" value="DME_0000120701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041120191" evidence="1">
        <location>
            <begin position="24"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000120701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="679" mass="75243" checksum="80080747C983FFBA" modified="2015-12-09" version="1">MRKFQVMKILLLSVTLSVVVLEGEKITRENMPAAKYYDGKKFVIPIAHKTMEDIRDRWLQQAMSGLITGVSLKKLGKSKNEWQVFSSNKHHNQPNGDEWIGGFHVSRAKRSDNRKANIISQNNYKLLTENTNRSPFGFIAQFLKKNMQYIKKKTDSKPWFAVVAEAKQLEAELKKHDALKRGLRRKLKLLSEARTKELSLDERRELNNPDILPMEGDFENMPLVIEDKLRANGKSGNIKELMKLARQGISLGMSLAGKNTTSFGKKVLRVGSPRFFSLVPDDDSDDTVNLLSPSLLNMHDKGNDAENLVSIPKLLKTLRSSKFKDHEDLLNLIFEASGISDHLKKAKIKNICLNFNCLRFVNFCHTVQMPLLMFKEKLQAENLKNARGIDGQPLYFTKENVTEMFGDFEKHKIETFEKLHKTFTNQQKADLNDTGLTTLTREQLFLIYGKDSPYQDLATLHRLTNITNDDHLQKLIMDDIHAIAKSKNIAVKKGDRHKRQVVLSPAALSVSVLRVSRMTPVILSPAVLSPSVLSPSILGPVILSPGLFNPSFLSPRLLGPVILSPGGFGPLILSPVALSPAVLSPGIFGPAVLSPTALNPSALNPGFGSPAVLSPFILNPGLLNPSALSPLVLSPFAFSPSILSPSFFSAVILSPNAFSPGIASPSQNVTVLFSPSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3F8</accession>
    <name>A0A0N4U3F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CTLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5622</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3F8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3F8"/>
    <dbReference type="WBParaSite" id="DME_0000126201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000126201-mRNA-1"/>
        <property type="gene ID" value="DME_0000126201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000126201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52146" checksum="AFF8385DB3F17C8F" modified="2015-12-09" version="1">MYISLCISVYFRFALLSLFRVVALLVSWLVGWLVGWLDSLVSLVGSIAGIDGWLHFGGLDDVAMVNVLDDFVKSFIEEHDQWHRDSLAKIQMSIDEVRRVLNDLMDGDADNGGDNPSLEKLGQIVLETSLEKLSNELQETKDCHLPLHSYLTKAKKQIDEVFFANLDWYSKPGKKFESDSNLHNLINHLIVEHLKCDGFLEVADMMLNEIGPLSSSSSELPSSTMAYDADVMLHILQAMIKKDARPAISWLEKYAPNEDDLIFDLERQEFIRLLRKGNQMEALDYGKRLSRKIEEAKTLFWCIVDKDREENFPEFFDDSLWQILQRRVARIFSGVDDHLRTIIEAGIKALPRLVAVRPILSNQDVFAVGELPTSTDAPLRYHSRVICPTKKVQCTEENPPMRLQCGHVVCRDAVLRSIVSGLQQPIHYTNIQSVPFARVTCNYCAREGSILEAKNLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3G0</accession>
    <name>A0A0N4U3G0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5624</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3G0"/>
    <dbReference type="WBParaSite" id="DME_0000126401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000126401-mRNA-1"/>
        <property type="gene ID" value="DME_0000126401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7480412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000126401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9050" checksum="50C4C2379A358623" modified="2015-12-09" version="1">MDIACRRSRSAQFSPEHRIANLKYANDVVLFVDSYNEMQVILNNVSATAARIRLRVNVNKTKAFSSYVQKADKMPLFVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4F3</accession>
    <name>A0A0N4U4F3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SLC12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6019</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4F3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4F3"/>
    <dbReference type="WBParaSite" id="DME_0000165901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000165901-mRNA-1"/>
        <property type="gene ID" value="DME_0000165901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000165901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26568" checksum="EFBF9F9AEBFE01C1" modified="2015-12-09" version="1">MTDPSDKHMNFILFFRVRRPTAAQRELVATISRFQRRIKGAVIDVWWLYDDGGLTLLIPHLLTLPKRYLEGAHMRVFTISTSTVTMEQEQRNMAALLTKFRINFSDVSVIPDIGKKPGLQMLVFDISYSQQEAFKKLIEPFRVPDATLIEGLITDSELSAQKEKTNRQLRVAELLHELSENADLIVLTLPVPRKRLISSCLYMAWLDIMTRDLPPTLMIRGNQTSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4M7</accession>
    <name>A0A0N4U4M7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6106</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4M7"/>
    <dbReference type="WBParaSite" id="DME_0000174601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000174601-mRNA-1"/>
        <property type="gene ID" value="DME_0000174601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000174601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7676" checksum="6D46F98183A0091D" modified="2015-12-09" version="1">MQLYHHRILTELNKVSNDLTTESTVKMRKRHNDDHDEDDGDNDGDNENSDGDGRDDCTRMTTTATSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4R7</accession>
    <name>A0A0N4U4R7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6152</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4R7"/>
    <dbReference type="STRING" id="318479.A0A0N4U4R7"/>
    <dbReference type="WBParaSite" id="DME_0000179201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000179201-mRNA-1"/>
        <property type="gene ID" value="DME_0000179201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000179201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27087" checksum="0433BD841F5B9AE0" modified="2015-12-09" version="1">MAPKFNNYRLLNQRIRRSLRFNTHQLRSLPMQLSELIVDYFDIYAPYDYMEFDYAASLTRFGCVDACTFLVAMVYVDRIRKLDKQFFETTDPNEIYISALVVASKFLYDDGIKESVYNDEWAVSASTSVKRINALELQFLDVIAWNLNIDENEFYNVLGICERWIALNSVKKFGFCTYNEINILYERLNLYLKCVRPLILFVSIAILIYVTSLSLMFVAFRLSCTFHSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5I1</accession>
    <name>A0A0N4U5I1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6467</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5I1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5I1"/>
    <dbReference type="WBParaSite" id="DME_0000210701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000210701-mRNA-1"/>
        <property type="gene ID" value="DME_0000210701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000210701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16415" checksum="9DA5374106C6F980" modified="2015-12-09" version="1">MDVASQAIIIHTLSKYRVDIACLSEVRLPHFGFRVIINPGSDQRYWLYHYGASNNSERNVKFDKAHSALSGNRVYTPILSVDDLDKDKFCVGLQLLTKSVPKHIITIEGDWNAHVGYDAVTMNSAKLNQEAPFVASNVTDAFAEPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5K1</accession>
    <name>A0A0N4U5K1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6491</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5K1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5K1"/>
    <dbReference type="WBParaSite" id="DME_0000213101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000213101-mRNA-1"/>
        <property type="gene ID" value="DME_0000213101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10685398at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000213101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="725" mass="81633" checksum="E27BE6E00C2CA680" modified="2015-12-09" version="1">MSFVINNIILQLYHFVPLGPMSYSITQSINNKLKYLISIIDNAIFIPLAIGRLYDISKPLNSIFHSCKIHFSQSFKNAIKIFHWFAIITYYNFFKDDVGIDTINFNKYSPQRSVYQNINEDSRNVRLLIENWQRANTNIYGKNSYSEILNDRNFWNRSASAAQLVVTEGRLYPAVRLQSGPYGSYQLGTTETDRYLADSQNNAPQIQSDFREKAGIADDPTYIHTSRGDDQQSHVATIPSNNHEKPTPPNNSNAGYPPEQFFLSAEQRMPSAEPKELDLSIYEGHPSQQVASTVGQETTELYSRLAPEYYQSMITEQPCLKSEIEPNQFHGPIGPSRLPTRNSYGDVEASYGLDHTSTTTIETLTPCINPTVLMIKEGDDFYTSVQPKASSIPVSKAYQLIDQPYPPSPSSPGQRTFTYDPNFAISQSFQQSFQEYKSPEYFQSPSPPPFSFTPSFTKNLPMQEMYQPLEPQPPSSSPPPSPPSLFTTFPPTFEEYQSQSPQLPLPPSQPPFIITTPPQIFEEYQSQPFPPSPSPPELPPISFTGKTETSMPSFFTQRSLTTGTQTFPFLTTSEMYSSTSGIVEIAFSSIPPTTTSPIFSTITREIVSPSRPFTVEEISTFISTEETKEKPFPVTTIQPSFPKFFTTTTYPSSPAIPSEIFTPQRPIPSMRITPAIVPNRIRGKALVVCGEDGISFRIITLFPFTGQIFSQDHKRIPSRIILILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5Q8</accession>
    <name>A0A0N4U5Q8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Runt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6557</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5Q8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5Q8"/>
    <dbReference type="WBParaSite" id="DME_0000219701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000219701-mRNA-1"/>
        <property type="gene ID" value="DME_0000219701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="5">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000219701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29182" checksum="D2BD4A7063D5D162" modified="2015-12-09" version="1">MGADYEKALIALEETMSAVNSSVKLLSTGCPNIICTELPTHWRSNKSLPTPFIVFALGPVPDGTVVTISAGNEENSCADLRNNKTCMNGQIARFSDLRFVGKSGRGKNFHLTITIETKPVQIAIIEKVIKVTVDGPRDSRTNKRTVTHRRSAASDESNINMKVRRRLSPVTIPRPVPTLVSPLPVFSPLFNSYSFVPNTPIAPATTRLPLTFASTIATHHSITPLSCSIPVNLPRAQLRMSNDMEEPIGARTRRKTTKIWKPYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6E8</accession>
    <name>A0A0N4U6E8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6850</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6E8"/>
    <dbReference type="STRING" id="318479.A0A0N4U6E8"/>
    <dbReference type="WBParaSite" id="DME_0000249001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249001-mRNA-1"/>
        <property type="gene ID" value="DME_0000249001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="398"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57192" checksum="A00D188F03F0A990" modified="2015-12-09" version="1">MLVEKLHIENSRTLIDLAKYIADMFCLLLFCSFPMVNCSSAEINRHLEMGKEFLSKGLLADALTHYHAAIELEPDNYKTLYLRATVYLGMGKSKAAVPDLNAVLQLKPDFIAARIERGNVLLKQGDLRGAERDFKEALIHDESSRELESKLAVVSEVKHHMEKANDLFVNNDCINAEKYYTSSIEVCQWNAALYERRAKCYVKSGNIMKAISDYKIVSKLSPTETDPYFTLSKLYYDIGDAEESLSQIRGCLKLNPDDEACFSHYKKVKKLVKMREVLNEKVQASEWMECLQQAEKILRFEKKVPNVQLDVFRQTCKCNLHAGHAMEAITDCTEVLKNGNPNDLHALCDRAEAYLLNEQYDEAIEDYRSAVNAHEDSRRAREGLNKAQKMKKQAGKKDYYKILRVKRNANKQTILKAYRKLASQYHPDNFPDEKEKKQAEAKFLDIAAAKEVLTDPEKRAKFDQGEDPLDPEQQQGGFQHPFYGGFPFGGEGFSFKFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6V1</accession>
    <name>A0A0N4U6V1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7039</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6V1"/>
    <dbReference type="WBParaSite" id="DME_0000267901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000267901-mRNA-1"/>
        <property type="gene ID" value="DME_0000267901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000267901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14622" checksum="CB02FE932F576054" modified="2015-12-09" version="1">TNVPLCTWCSENKIEVLLLPCAHAVCCNSCKQKYIDIEQNKNTLLSSKRNVVCPICRKKVIEFAFIWFFSNSCSLCGCNTLNAVAGGPNGCGCVIGCYEKAIEWRKERKSCPICNHPLDEIIKIFIQADIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U713</accession>
    <name>A0A0N4U713_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carnitine/acylcarnitine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7109</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U713"/>
    <dbReference type="STRING" id="318479.A0A0N4U713"/>
    <dbReference type="WBParaSite" id="DME_0000274901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000274901-mRNA-1"/>
        <property type="gene ID" value="DME_0000274901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000274901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32455" checksum="9D3F1FE1E4D19822" modified="2015-12-09" version="1">MSSSNQNFLEHFIAGGFGGMCCVATGHPFDTIKVRIQTMPRPAHGEQPLYTGPLDCLRKTVQKEGFFTLYKGMLAPLIGVSPLFAIYFGSCALGKWLQQKSPDQQMTNLQNFNSGALAGIFTTIIMVPGERIKCLLQVQQSGNALKECATYSGPLDVVKKLYKQGGITSLYRGTAATLLRDIPASGMYLMTYEYLKKLFAGPERTLSPLATLTAGGFAGIANWAVCLPPDVLKSRLQTAPEGKYPDGIRGVFREVMCEEGPRALFKGFTPVMLRAFPANAACFLGFELALSFFRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7A4</accession>
    <name>A0A0N4U7A4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPB6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS89</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7A4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7A4"/>
    <dbReference type="WBParaSite" id="DME_0000286001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000286001-mRNA-1"/>
        <property type="gene ID" value="DME_0000286001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000286001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13821" checksum="A822E16A3026FC79" modified="2015-12-09" version="1">MADDDDYDVEMDADDYGDEEQVGDLDLEGGDDLERAGEKTAAAERVTTPFMTKYERARILGTRALQIAMGAPVMVELEGETDPLEIARKELKDQKVPLIVRRYLPDGSFEDWSIDELDFTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7C2</accession>
    <name>A0A0N4U7C2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS109</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7C2"/>
    <dbReference type="STRING" id="318479.A0A0N4U7C2"/>
    <dbReference type="WBParaSite" id="DME_0000288001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000288001-mRNA-1"/>
        <property type="gene ID" value="DME_0000288001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6152532at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF2">
        <property type="entry name" value="RIKEN CDNA D630003M21 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="408"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000288001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="794" mass="90303" checksum="4EF5023F9141A700" modified="2015-12-09" version="1">MYEWALLNAKRFDGDSCKTLLIDIYPAAAASILSEYSVTCNDQLMRDEIDTLLNDCEKALEILKCEVSIVENNKTCYNISEHPVSLSSLDGTSAFSSRDAHKVSIFNKDTHNFNRIRKIQCHSADYEGIRGSVDIPEESERYPVRSTRSFNNILDVENHFERTSLVETLSNDNVLSNMAGEKFAEMDVLNVDEFRYAGRSDSVSPAPTQYEIPITKDDDQRIYEVNDDGEKIRWRNYSWSPINNSVVPSISASFRQEEVSFFDDIGCAPVTLDLTDKIIASMSSKTLHKHLDQRRSSTSIPPPGPLSNNGWIRPGSARFALGSKSRPPLLRNLSSDFLDHRFPSSFGVCHSLDESKYSTVDTSRPESCVGSGPFKTDCSTQSEQICMIYDWLNPSKTSNANYRIECTVVRDLLDTEIEYVSALRRVVQDYLPELVRADIPSHLRGKKYCVFGNIERLFQFHAHNFLPQLISRLSYHEKSESLSLTIGKLFVDCLNFFNLYSLYAKNKPKSDQLLRDYANDFSTIFHDLKDLSILLMRPVERIAKYTLVLQQLFNAAPLDKLNIIEILDSVVAEIGGQIRRGSDLLAMERITCCDLNLKEQGKLIRHDTLFVIEKHGLLHSKKRIRSSFLFEKCVVLTKPKLRKLSRGCTYDELKYKASIQAQSPTVRDAWIGHIRCILWKQAIHSREESNREKASMGDATYIHLGPNSYANVSDFDSTEGSRRPRSLISLSVSTCSSSNIFRMIGSHDVNLELDRVEESEELEFSNDLNNTVSYRRKIEGSTLPRHYAPPPPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7M8</accession>
    <name>A0A0N4U7M8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PFK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7157</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7M8"/>
    <dbReference type="WBParaSite" id="DME_0000299801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000299801-mRNA-1"/>
        <property type="gene ID" value="DME_0000299801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000299801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15776" checksum="CFC789E867AE2EB2" modified="2015-12-09" version="1">MRIAISTSALSIKSTPFKNEIHAALSLYLPNRNVSYTTSEDNDDVLLTLKHGEESQNSNKRNPYKIELINTQLKQSVLGTWFIMNKVCMDLQKGGMMIMCGDESRTHEGYLSIAENMEIPLVNWDLAPVLPNDGPVNKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U803</accession>
    <name>A0A0N4U803_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7306</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U803"/>
    <dbReference type="STRING" id="318479.A0A0N4U803"/>
    <dbReference type="WBParaSite" id="DME_0000314701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000314701-mRNA-1"/>
        <property type="gene ID" value="DME_0000314701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000314701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27822" checksum="53486E2EF935C5E9" modified="2015-12-09" version="1">MVNDKNPEITHVIFDLDGLLINTEPVYTEVNSYTMAMFGRKFTLDLKALTMGMTNEAAISLMLEKVGLSGKVSVDEYRAIYNPLLRSKLPYCEKMPGAMRLVRHLAINNIPMAICSGTRSYEFKLKTMNHRELLDLIPLRVCASDDPSIHEGKPSPDAFLVTMERFEIPPASPSNVLVFEDAPNGVIAAVRAGMHVVMVPDFTYSKPPEAVEDQISFVLKSLEDFEPETMGLPSYNNDKISPFISSWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8K7</accession>
    <name>A0A0N4U8K7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS253</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8K7"/>
    <dbReference type="STRING" id="318479.A0A0N4U8K7"/>
    <dbReference type="WBParaSite" id="DME_0000338701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000338701-mRNA-1"/>
        <property type="gene ID" value="DME_0000338701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000338701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8725" checksum="F4CA44A0EAC9F643" modified="2015-12-09" version="1">MAMKISINTALFCGQFAISIMHTFFMFYYVKIFLNIFKIDEYIFNLSQIFLIVWNSINDPIFGYIQYHFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8V9</accession>
    <name>A0A0N4U8V9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7502</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8V9"/>
    <dbReference type="WBParaSite" id="DME_0000349701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000349701-mRNA-1"/>
        <property type="gene ID" value="DME_0000349701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039952">
        <property type="entry name" value="Aex-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21643:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21643">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000349701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36604" checksum="851995DEA7DDEBCF" modified="2015-12-09" version="1">MKTSGENDSSITSGNSIRIICYESEIFETFQYTVDDMLLAASMAATVFNVMVTFCAAKLFRKSGDTMHLFIISMTLGDLLLTVFCHPNEFLTRKHEFLRNDLLCMIIHFCNWLGLAVSGLSLTMLNIDKLIYFQWPLSYDRAMSKNRAIIFCTAIWMTDKKRYFYEFFMVVFCVLPVTSSAIVSGYLYRLTREKRNASVRSLVFIFATTTWTSFSLLPYRIFNICRIHLFEWNTIECVPRQQLHWLAWTLLYLLTLNPIINPLITALIYTPYRLTIKKFLINIPIGNRPIYNYRTDVCTDTRFRSLIFLVNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8X9</accession>
    <name>A0A0N4U8X9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fatty-acid and retinol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7524</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8X9"/>
    <dbReference type="WBParaSite" id="DME_0000351901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000351901-mRNA-1"/>
        <property type="gene ID" value="DME_0000351901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016918">
        <property type="term" value="F:retinal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019841">
        <property type="term" value="F:retinol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0845">Vitamin A</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000351901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17985" checksum="54611BE30ED9A428" modified="2015-12-09" version="1">MTEFVKNLEEEEQAILIRFLQNLVDPKSPVTVDNFMGTIGTASKKLHGKIKNVICQLQWKILMFEPEAKYFLHQVFHEGIGLLRTAKKSKNTLDNKRFIGIFLDVTNKLTEQFFQLSAKNQEAIKSAFPGLFKLTQELKEIHSRLKPWEGNSMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9C3</accession>
    <name>A0A0N4U9C3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Low-density lipoprotein receptor-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7679</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9C3"/>
    <dbReference type="STRING" id="318479.A0A0N4U9C3"/>
    <dbReference type="WBParaSite" id="DME_0000367401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000367401-mRNA-1"/>
        <property type="gene ID" value="DME_0000367401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062665at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF59">
        <property type="entry name" value="LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000367401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47058" checksum="BC28416BC1223E62" modified="2015-12-09" version="1">MRKLKNYICPSVLVQKAMARIEHLNNICHTTFNCSTQKKYVKCLRGMKLCDGVRDCVDNSDEELYCKSKCSENEMICEGTRKCLPLEFKCNGDFDCEGGDDEEFCENRCVGGSKWCAVSKKCIPSWQICNGIDECGDGSDEEQCDCQLCSGSNKALCAITKKCITREKICDRNEDCHYGEDELQCPGGCFEVLVKQHEEMIECADKKKYVKKYACSGMLDQCKHFCEECDKELAFRCGNGLCIPRNKFINIYLIYLIVCDGNNDCNDHSDEMKCGCSDIKSLNETATFFFCNVSAKGVRKCISISQRCDGYLDCEDGADEINCNECTTNSNAIYCNLTRTCLASIKRCDGVQDCPNDIDEFECSCKECNIHANPMYYCSDSARCYRHNKICNPFSTCPYPQDSDRQYCAYKDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9K8</accession>
    <name>A0A0N4U9K8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9K8"/>
    <dbReference type="STRING" id="318479.A0A0N4U9K8"/>
    <dbReference type="WBParaSite" id="DME_0000378001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378001-mRNA-1"/>
        <property type="gene ID" value="DME_0000378001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29470" checksum="306DCEC94A143EFE" modified="2015-12-09" version="1">MSRITDGTSWLSLGSKSSPYNVIFNSLNRHIHPVSFHSPFPDLYLLYEEASNTQDVLTFMLWKLWIVASDSCIQYFLMAWKWLTFGDGERCILLLIALTKSGSIKSLANYGAIATQFVATCLQVYRQLYAPNPFASETDEDIQKYMKEVESKTPRPGSVSDNTTNGRTAASSPPPFETDSPSAETISLMQAARQHRSRMITAGASSIDEETALNTIPDMDNSHIGRLTLETTFDESDMPQSRIVCSTPVASIHSDRMCGGSWSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9T0</accession>
    <name>A0A0N4U9T0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DME_LOCUS7867</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24 26" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9T0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9T0"/>
    <dbReference type="WBParaSite" id="DME_0000386201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000386201-mRNA-1"/>
        <property type="gene ID" value="DME_0000386201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912975at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045138">
        <property type="term" value="P:nematode male tail tip morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000586">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF602">
        <property type="entry name" value="PROTEIN VER-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="208"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="534"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="629"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="809"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="778"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="816"/>
            <end position="823"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1001"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1015"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="VDN57894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="DME_0000386201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1199" mass="138425" checksum="0B8AECFCFAF807A9" modified="2015-12-09" version="1">MLYPPQINGFGNNLSEYKGQEYMELETGKKLEISCSSMENIHWILPNNFLSSGYNSQEVESRLEIYEEFVGLKKLTLKNLKQSDTGEYICTSQPSAINTSIYVYVSRKNKGDKSIFLNDEPLIISTPFNRPFITVPCKTNRFISDQPKLFINHIEQQGKFDYDPRYGFSVEKELFPSLSETSIKCEYKDDKSEIIVVPEGDSKLDGLPVIEVQNRWPYVGQSLEISCTFHMKPTYKYSLKWRCPRCEQDTDRISSNQYVKINDGIRKMIYIDDLKTGDSGIYDCSLVNRDDPSDLRTSVYELHVSKTKGQLKIIDTALDEEYSEGDVIKLFHIAESFPVNDYNVQWRKIYKTCHTFPHQNIETISAGYTSDFKDNIHSEQLIIENAKVEDSGLYQLTIKVSDDLVYHKNWTVKIAPRDIQPMISVFHSNTNELVDGPVMVNTDIYVLCYVKDIRHRNLYLSYKSALGSNWIDIATENLDNLTFESAIIHHFVLQTTIIFKCKLENIKNDIEKKIIATEIDKIAVEFNVFKGTDPDIAQYENKDIYEGDSVHLKCKLPPTEDFNVRWIKDRQELHSPEIFGEETFTSYINEIDGIRIDQSGDYRCVAFSTVDQSTREASLKLKVHEVVAPQINQMLAKDMHEVNYGENTQIICPIQGFPEPIYRWLKDGAEYNGIGNLTKILGFPRIISEDKGIYTCKARNRAGSQEFSTVFKILNEPEYVKSSRYWWAFGIACFFVVLLIIAIGFIIKQRRRTIRQQHQLQALYNQLMGVEDSSLRDYLIQPVDSKHPLHERLEQMPYDRKYEISKDRLSFHQLLGGGQFGQVHLGEIHRNMVSDITAAPSSIKVAIKSPRDGRNINHQKTLADELKVMIAIGIHPNVLPLVGAVTKQMSSGQLFVVMEFCENNNLKEFLTRNSGGFLGEIELIEEPMNADGYLTPIGMVQQPLQIYRAEVEPSWANLVDQERMNDKMLTTSDLISFGYQIANGMQYLAEKLCIHRDLAARNMLVTKQRAIRISDFGLARKDKRLYHIKNSQSTPLPFKWMALESILNHDFTELSDVWSYGILLWEIFSLGRVPYPQVPNDDLIDYLQKGNRMEQPKAASDDIYTLMRQCWLTDPNNRPNFGQCKNIMKNHLDRASPVLSQRLQKILEEDKLKMERYTEWRDLETEEDLRAQATRNGFISVPTQEPILGNEYIYTLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9X2</accession>
    <name>A0A0N4U9X2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7918</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9X2"/>
    <dbReference type="STRING" id="318479.A0A0N4U9X2"/>
    <dbReference type="WBParaSite" id="DME_0000391301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000391301-mRNA-1"/>
        <property type="gene ID" value="DME_0000391301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="237"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000391301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46118" checksum="A158977AA8DB0C51" modified="2015-12-09" version="1">MDYPSWISESIIDVYHKSGLKKLFQWQYDLLINDKIRYPLSSNLLYSAPTSAGKTIVAEILALHTIIETNRAALFVFPFISVAKEKFRNLQKLWRNFNLRVCGYMGPNSAPLTAWDTAICTIEKANSLINKSIDEDALERISVIIIDEFHMIFDPHRGQIVENMIAKIRYASKKLNNHIQIIGMSATLPNLEKLSKWLNAFSIASDFRPVHLSQLILTNNTLKDINTMETKKICSLCMESLYAKQSVLIFCSSKAETEKISLNFVSYMIDVDFDSRRLSSLLDLDQLSIFLKKFHSRTQSNDELLRKTIPYGVAFHHAGLTVEEREEIEDGFRNGLLKILCATSTLSSGVNLPAQKVIIKAQFNGPLALSSITYHQMIGRAGRLGQTVDVDFLSKKLDIDVIANCSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9X3</accession>
    <name>A0A0N4U9X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7919</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9X3"/>
    <dbReference type="WBParaSite" id="DME_0000391401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000391401-mRNA-1"/>
        <property type="gene ID" value="DME_0000391401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830708at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000391401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30378" checksum="7ECAE73A4C7085CB" modified="2016-06-08" version="2">MNGKVVDWCQFYVNRKVELASITTSSIVDTYFKGIFLRFYQMISLYFHLLISILICGTYASFLYAKWDNYRHNIHHTCANNEECDENFGLIWPSYKFICCTTIVCDENYGDYYFVHSGCATQQQSRLERKIFDLLIPSIEKGCFATRENFLSQNFNNAIVITEQSVPSTTTTLPLRIVSPANCSCPIELECCIHIECSDNLQIDTRNYDVKSECSSKCLTIVNRIGQQYSFYLPKDIWQKRVEYEREESAPPVEKSCRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAK3</accession>
    <name>A0A0N4UAK3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8068</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAK3"/>
    <dbReference type="STRING" id="318479.A0A0N4UAK3"/>
    <dbReference type="WBParaSite" id="DME_0000418501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000418501-mRNA-1"/>
        <property type="gene ID" value="DME_0000418501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF60">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="42"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000418501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41401" checksum="DD5F6B740763C2A7" modified="2015-12-09" version="1">MLNKTFQIVSNNKNCTSIIEFTFRNFLIGTCFIIIFCLSVLGNSIVIGMIAKLRRRSIRSITNIYLLNLAIADLMRSVMCMPTTLLSELSRCWLLGPLLCKLAAYLQPVAVSASAYTLAVIAVERFYAICRPLQSRKWQSKRRALAMIALVWIISFISNILSLFFYKASPYKSAWNCRSVVSPLVDFIYQLYLTFILLLIPLTIMVVLYGNVIATLKTAIYLDCDKAITVKNFDDNNLDALIAKKRVTRMLIILVIAFLICWTPSFIWWLLIKTTDLLEAYHVYNDSMNTILTLLTYISTCTNPITYCFMNEGFRDNVFAHYLCCSSVYEKHKRNRSTCESPSSPGFLSRFIPVGNRTPVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAW8</accession>
    <name>A0A0N4UAW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8204</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAW8"/>
    <dbReference type="WBParaSite" id="DME_0000432101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000432101-mRNA-1"/>
        <property type="gene ID" value="DME_0000432101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000432101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10066" checksum="CEEE3BA3E348568C" modified="2015-12-09" version="1">MPKYDLCHFENCFDCLCGLGQSYTVGTDLNSRAYLSAATMVMYANSFSTCVMGFGFYFLAYYKRFYWCYCLILNKLNNFKEANLSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBD2</accession>
    <name>A0A0N4UBD2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8389</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBD2"/>
    <dbReference type="WBParaSite" id="DME_0000450601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000450601-mRNA-1"/>
        <property type="gene ID" value="DME_0000450601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000450601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7807" checksum="4559869CEF6D9DA9" modified="2015-12-09" version="1">MARFPDSYQLKDVKSDAKDPFISLSSATPYLNSKPIRLMPYFKLIEAILFSNVSIMRGFIHIDYEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBP7</accession>
    <name>A0A0N4UBP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8524</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBP7"/>
    <dbReference type="WBParaSite" id="DME_0000464101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464101-mRNA-1"/>
        <property type="gene ID" value="DME_0000464101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12287" checksum="64A3D36B94A4B887" modified="2015-12-09" version="1">MEDEWSSPIIIKDEYLVSAFPYNTSLQEHCLQENMAINFQFNSGHIPIVSDNDDSDDSRQTRNHLDTDNEYRMMIADSFDLSGINCLATLNDDIENYYVAGLSFIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ5</accession>
    <name>A0A0N4UBQ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CTF/NF-I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8535</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBQ5"/>
    <dbReference type="WBParaSite" id="DME_0000465201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465201-mRNA-1"/>
        <property type="gene ID" value="DME_0000465201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055441at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="9">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31536" checksum="C5987DF07DCBEE35" modified="2015-12-09" version="1">MERIQMSDTGEWVQQYSANEEYHPFVEALLPYVKDFSYIWFHLQARKRRFTKKNEKRMSVFDEKKAKDDLMNESAELKQKWAGRLLGKLRRDIQPNYRQNFVLSVTGRRPAICAVSNPDQRGKMRRIDCLRQSDKVWRLDLVMVILFKGIPLESTDAERLEKCPECENPSLCVNPYHISIAVRELDLFLANFIHTNNPDRPDEEDEEDIDSGKVFNMQYDEPVEKRSRHASRDSIGGVNEEVHQLVGNIQVEIKRERESGRANSGHIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBU6</accession>
    <name>A0A0N4UBU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8583</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBU6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBU6"/>
    <dbReference type="WBParaSite" id="DME_0000470001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000470001-mRNA-1"/>
        <property type="gene ID" value="DME_0000470001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000470001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1156" mass="132540" checksum="3CFF75181FB61B60" modified="2016-06-08" version="2">MELVEELAVELVEDDYPGLVKEAIAEQGSQKNGIQFNSCATLSSIGYVRMIVGRNLFVWNFTNEDKTFETPKQLLLPPSGLPYSVATTSIYLNTGFSDPGVLAVSPEGVIRHWPVVGRQFNDSVVELQSEVALSLLVLNGHGSDTLHFLLSTTTCSFFLLSVEHTASTDKPHWPSVSVIAKLIYSDIKRGIGSRVTSVLFGGITPIRSHLIKSLIYEETSGDSESENGFEVIKCFKNRVSNMFILALKESELELYSISPPAKLWIYNLSERPKLLQMTSGESEYLVCKPELLKIWLIDAVNFRSGMFVLLACSKLSSNAVVHFGIGYIADYGRDVMPSGFEWFQIMKLSSGELYRSSDEQCFMKISLRVPTRLRSGSHEFTEGIVMVTSKSVYAIRLPNILDNHAFPTIYSLKLEDEIISSATDANFSYVFLRDGGLYRIRLLPRGFDATLAQSIKINLFNSQEMPTSFPSEGRLLANAFLSFTKGDMLNARTILNDLLAIRHTTMAQLCIEFAVGIVNDIPNDKRWIDAGYEPKNTSLSDQSFLIEVHLAVQKKKILAMFVLFIQSMQLNFQVVFASLSLFYFSTCLREVYFQFDKVIKTVLTDSRSARSQLTELIEKLEIAIAIYDVRYNEFLECQRPVMISAIKRAVDAEEHFRNEFSFTLALYDYFFQKITKIDRIFTFLLEEQKLKIKDNLGQDIAIKWVEDSTFVVAKALEAVTLIRAENPFHTGDDLLWTQQKPFVDLIIAQVDIALEVARTHKKLDTFSFFETILKISFFILEQMDSASVDKSAFIQKFFNINVNAAIDLAKFFKDYISLIKYVENLPYNEMIKKIKEFKSAVDSPDFNAVLYEFYFRKGYIKELREETGDFCDEFFATHKKISWLRYLDRGEYEKAYRCLKTLIQQCEDIMEKKLYLSFAKLCLLSADSVDEDSLAEIHNSFSVIKHQEEIPLDLTKKIIPKVISASDDGKKKMRPLTIEELIQINLSDTDEERVLSSYSRALRIFISLVQDTSAEFHSELIGSLRSKIWLSILRSDITDWPTLNLDAVKNTKFCLVLDWMLDAEIDSRYKIKALPNVHELVNVMPELKDFPSTALLFEAEEEKAREKLMNSVVYENEFENRIPYRPPVKSNLIHDEDENHREKISFYKSYRWKWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCD5</accession>
    <name>A0A0N4UCD5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Vesicle-associated membrane protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS545</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCD5"/>
    <dbReference type="STRING" id="318479.A0A0N4UCD5"/>
    <dbReference type="WBParaSite" id="DME_0000492401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000492401-mRNA-1"/>
        <property type="gene ID" value="DME_0000492401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039524" evidence="16">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN50572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000492401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24564" checksum="5D0D16339ECE54D6" modified="2015-12-09" version="1">MILLTLIARVRDGLILATSIEGGDDTDNNMVKYTTQAKMLFRKLNAGSPPVHTVESGPYYFHYYIKDSICTLCLCDKNFPRKSAFAYLSDVTNEFLGQNGTRIDTVTRPYHFIEFDQYIQQAKIKYADRSRHAMSAVSSELQDVTRIMVSNIEDVIHRGEALNILETRASDLSDLSRKYREDARQLNRRNFMFKAAITLCILGFVGFIARFFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCR5</accession>
    <name>A0A0N4UCR5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="10">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="10">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="10">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS8869</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="10"/>
    <dbReference type="EC" id="2.7.7.50" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCR5"/>
    <dbReference type="STRING" id="318479.A0A0N4UCR5"/>
    <dbReference type="WBParaSite" id="DME_0000507001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000507001-mRNA-1"/>
        <property type="gene ID" value="DME_0000507001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:7-methylguanosine mRNA capping"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="12">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
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        </ligand>
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            <end position="305"/>
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            <end position="426"/>
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        <location>
            <begin position="494"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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            <dbReference type="PROSITE" id="PS50056"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000507001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63750" checksum="987C06735F616250" modified="2015-12-09" version="1">MAEIDEDSFYPDPDGPNAEKARLGPPDRWIYCPAVGSVIAKHFLPFKTPLCKLYDEYIEGERYLFHPKDIFANPLKGADPGAKIGLWIDLTKTNRYYSKKEVESRGCVYIKMAMKGHKEVPSEAQTEFFCNLVQDFLLRNPKDVVGVHCTHGFNRTGFLITAYLATCLDWAVDAAVHTFAKHRHNGQPLFMSGAVPRVTYVADSMMRGILQSKIAQMCGSTRDGFPGSQPVSMERSPENNNLHLLAENDYMVSWKADGTRYMVLIDDEDSVFAFDRDNNVFRIPFLYFPHRKEKRHIRHTLLDCEMIIDKVVDDSGMQQTVPRLLVYDIVKFEENNVGACDFKTRLFCIRREIIGPRKEAMQRGIIRRENEPISVRVKDFWELEAVPKFFSDKFTKNVGHEIDGLIFQPVHEAYRPGRVDTILKWKPPSHNSIDFKLQIRKICNVGELPEYVGLLFVQHEATPVAQLKATKKLLPYDNKIVECNFVNGKWQFMRERTDKSLPNSMKTAKAVFNSIRYPISKTDLINFVESTCISRAKKRNLDNCSSNLSSKRAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDA9</accession>
    <name>A0A0N4UDA9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9104</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDN59131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UDA9"/>
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        <property type="protein sequence ID" value="DME_0000530501-mRNA-1"/>
        <property type="gene ID" value="DME_0000530501"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN59131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000530501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28372" checksum="AEBF821A1EE2232E" modified="2015-12-09" version="1">MAAGDPPVTLSPSDSVVKGSDILDKGSASPDAHDTPSPVVHAISIQSGLKAIPRLANKMCSQARVIARNLSRETAFCMRGKILAVSAWNVRTLMDAASQAIIVHTLSKYRVDIACLSEARLPHFESRTIINPGSEQRYWLYHCDASNNSGRNDVANVMSEKAYSALFEWISHQCPTLSANDRDKEDKENKFYAELQLLTKSLPKHDMIIMGRDWNARVSHNAAAMTSTIGKYGIGARNHYWSDMAILNNGGSKKSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDD0</accession>
    <name>A0A0N4UDD0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9129</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UDD0"/>
    <dbReference type="WBParaSite" id="DME_0000533001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000533001-mRNA-1"/>
        <property type="gene ID" value="DME_0000533001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410920at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000533001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41471" checksum="BD52E0903999E4AB" modified="2015-12-09" version="1">MSQSLSSSASSPSSLSVSSKCSAYVDASPQLTTTSLISSPSNDNLSRKRIAATRLPRISLSEDSQSPRDITTQTQNDIIDVKRQRIADATQRTDNYVLNDLIESQSRSPYGCPDRNIDPKLIDVEKFRKLMAVRHRLNEAHKYWKYGDVDQMREFVLPEDCEICESDRGQRFLFLPWQYGSLQSKIGANKLSEAAVRPLFKQIVRAVAFCHSIGIIVRDLKLRKFVFIDEELSRLRFRDIFDMHVCKNVGDDGLRDRHSCPAYVAPEILIKSSPEYAGLRTLLYCLLRKEPLERPSAEDLLHIPWIFNNSAMAENIEQRSSLDIISHLQFNLSSSTHRYSRRDDQEEDQVVPSLSKKKGSAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE87</accession>
    <name>A0A0N4UE87_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS722</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE87"/>
    <dbReference type="STRING" id="318479.A0A0N4UE87"/>
    <dbReference type="WBParaSite" id="DME_0000567701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000567701-mRNA-1"/>
        <property type="gene ID" value="DME_0000567701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF18">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000567701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58147" checksum="409B243A34328C88" modified="2015-12-09" version="1">MYRYTTAIIMMIMLMHCNRTDFCYSPLNLFIASKMFEQVFDELAKRFGFDKELFCVIQLGIAFMLVFVGFDAQAFIAENALHSIAFLHPGRINNNAGYYGMAITYLSFTLMTLVTPIIVNKIGAKWSMFAASLVYSLFMLLFILVNNYLYYVMSSLMGAAAACMFTCTLFVNSLILWNGHGVYIKQITSTGNVSRNIGLHWSINFLSSVFGGLIMLIILNKTKTMKYLTMEVIGYIFYGLAITTVMSNILFFFLPNYSVNKFQLSRNFLKNLEKTFSLLLDRRMWLLAICFLYLGFLLGFYLSILPSSMLFSKFIVGYGNEIVAYYAIVLGSGEIIAGLFVSYMSKRIEGFGFMPTMLLAIPLHSCAYLGVLLTFPSDANFHPTTSTTNAEMKLYSANFSLSCWLIISFLLAVGDSFWNTIRTTVITHLYQNNSSQAFALSKFFQVMYLSKDSLATSSILFGSDLVTLHWQILLLASFLIFASISFSILWRINKDDFIAPKMEVAVITAEVKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEH6</accession>
    <name>A0A0N4UEH6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein light chain Tctex-type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS777</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEH6"/>
    <dbReference type="STRING" id="318479.A0A0N4UEH6"/>
    <dbReference type="WBParaSite" id="DME_0000578301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000578301-mRNA-1"/>
        <property type="gene ID" value="DME_0000578301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000578301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12761" checksum="B80D0695241E5D55" modified="2016-06-08" version="2">MAENSAHVEIPGAPLNHEVQSISKEALDNIIGNSAYQHLTTNQWSQQAVETITTSLVKLNKPYKYIVTCVIMQTNTGAGLSVSSTCYWDKSTDLSFTVRWENKSVVTIVNVFAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEK4</accession>
    <name>A0A0N4UEK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromatin assembly factor 1 subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS808</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEK4"/>
    <dbReference type="STRING" id="318479.A0A0N4UEK4"/>
    <dbReference type="WBParaSite" id="DME_0000581401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000581401-mRNA-1"/>
        <property type="gene ID" value="DME_0000581401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="8">
        <location>
            <begin position="118"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
            <begin position="299"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000581401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="56720" checksum="83E1B1C809A8829B" modified="2015-12-09" version="1">MDELKENSQPTSLKRTLEETESEQLSGKKQKFNLNKDEQESATKKLFHERVEPVSSSQQSDAVVFGDEDNEKMCYSLITTTRNESDTGKRAKSSRNESGERKEKERRLKVELKQLRLKRAEETKEKKLQLQKEREQKKIEKEREREEQKKRAEVRKRISNELKKAKELKRNEEELRKVRKRKEEELRKEQKRKDEEEKKEKKQKEKEAIEMKKKRESDRFLSFFSKKERPRVITLSTDLQGPFLPFEIKEGMTVAPAYRRSPLSPNTYQNLLNIPISESYLSNLPRLLPTKNRDDTRAKLYQFHHSYRPPYYGTWRKKSKVITGRRPLAKDLELINYDIESDEEWEEPEGDNCESNEDETSSDDDGEESDEENKFLVEHGYLSEDEGVDTDTDKESIQKEDREKRRERLREKAEEWKQNIEQKVKKYEKLIPILYGPKFDEPSPAASLYIQRAFVIPYCDNGIGKFSKKPDDINESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGE5</accession>
    <name>A0A0N4UGE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1292</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGE5"/>
    <dbReference type="WBParaSite" id="DME_0000656301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000656301-mRNA-1"/>
        <property type="gene ID" value="DME_0000656301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867083at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039204" evidence="2">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000656301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21506" checksum="96B79ED8E5F3D03F" modified="2015-12-09" version="1">MLALLLILAFLHNVDSIGVQLNRCLASSLPAVPRPWPHPSACKDKYPVICNSLFSPLPSDLTHNSIMTNPYLVNPNCQNSTLLAAAEMLCPSSCALCCLTPDYKCKNSAPSCSAFSHKPEMCTDPQTAAEALNGCPATCGLCTKPGANGVCSDTPGAPCEELKPALSCYNKYMRQNCMRTCKFDDCKHWFHSNAAEMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGN1</accession>
    <name>A0A0N4UGN1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS9683</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGN1"/>
    <dbReference type="STRING" id="318479.A0A0N4UGN1"/>
    <dbReference type="WBParaSite" id="DME_0000665701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000665701-mRNA-1"/>
        <property type="gene ID" value="DME_0000665701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="53"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDN59710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000665701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39161" checksum="74AFBB29B8424999" modified="2015-12-09" version="1">MTPMIQHRLEDNVTFLLNQLIASHDRRIRPNYGGKLIPFVLIIQIVVVTGLKGPPTIVNVTAHITTISAISEVSMDYTIDLYLRQFWCDPRLSFVSYDQNSLTIGIDVVKNIWTPDTFFPNEKKSYFHEATTHNSFLRIDKKGNVLRSIRLTVTANCPMNLHKFPLDIQICALEIESYGYSDRDIIYHWHQGTDSVTIDEKVHLAHFSIGEHFHVERVISLSTGNYSRLSTYFTFKRNIGFYLIQIYLPSSLIVVISWVSFWLNRDATQARVAIGVTTVLTMTTLMTSTNASLPKEIGNGMNKLKWTIMGKEERQIDRQRSGMGLQQACHLDDGHLHRQMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGP5</accession>
    <name>A0A0N4UGP5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ephrin RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9703</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGP5"/>
    <dbReference type="STRING" id="318479.A0A0N4UGP5"/>
    <dbReference type="WBParaSite" id="DME_0000667701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000667701-mRNA-1"/>
        <property type="gene ID" value="DME_0000667701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02675">
        <property type="entry name" value="Ephrin_ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF29">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ephrin RBD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000667701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15380" checksum="5D5EDB8169F81606" modified="2015-12-09" version="1">MNFDISNTDHVKPVKLLDRISFVCPDPNLQADKYEYTKLYAVSKEGYDNCELQNEKLIGVCKSSNKQSIISIVFRDFSPLPGAVEFQPGQSYYIITTSDGTEEGIDNRSGGLCYTRHMKIKFEIHSGNLFFFKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGW3</accession>
    <name>A0A0N4UGW3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1366</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGW3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGW3"/>
    <dbReference type="WBParaSite" id="DME_0000675201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000675201-mRNA-1"/>
        <property type="gene ID" value="DME_0000675201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431939at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000675201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33818" checksum="518CD0D496EAC649" modified="2015-12-09" version="1">MSTNRSFIVLITGQIDYGQFPLIDNIYCKFSYVYGSDWRQIAGIEEGISAKCVKGTRQDKIVVGLPLEATFTSTNPYGWPQICISCYGLDCFGNDVPRGYGAIHLPTAPGRKTLRIPMFVPEASTIMQKWLGWITGRRAEFIEPRIVAYADGRQATKVRTQGFIYITLNTVLKDIKKLGYDVQSDTFAKYSHFPLPDFNNKERQMPEIRQTIHKKDEIQLKDEFIERQRNDYHLMEPISPNSSTGKLRTEEKISSNSDLEIKNIGEKNYVRPLPLPTPLPRIQPRSTSSTVDDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH22</accession>
    <name>A0A0N4UH22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1430</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH22"/>
    <dbReference type="STRING" id="318479.A0A0N4UH22"/>
    <dbReference type="WBParaSite" id="DME_0000681601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000681601-mRNA-1"/>
        <property type="gene ID" value="DME_0000681601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000681601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47951" checksum="F96F6516175CF648" modified="2015-12-09" version="1">MITDIHSCGSMVLSLASCLGSIPGRRNSLFGRTTSIWFFGFWNQKTMSIRYPVSCGLAFMAAGNLIYFTLPAFTENHSWFMLLARFVAGIGSGNLVVLRAYCAMASLQRDRTRAMSLATIFTPIGKKGFAFGVFVLNMYTAPALLMVFVAFACILMLFTVFVEDYAGIISKPDKRDSSNVIPKFDKVAVGICLYLWFTLQSISTNIIFIATPFTTSLYRWTDEEAVFYNGILLFIGSAFSILNYLIVAYSSIGRIDKRKLLVFSLLLLLLYHLLVFPWPFYEGPLHSAFVEDTSINGGCYRKYDWCSHTTRVPLMIYLFCFVIVFGFASPYLSATLGTIFSEILGPRKQGMMQGVFAFAGCFACSTAPIFLTALFESSGYLWPTLLHIIMVLTGLLLLLSFYNRIVPLKVIPDIGVPTPYKFGVFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHG2</accession>
    <name>A0A0N4UHG2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo segment polarity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9790</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UHG2"/>
    <dbReference type="WBParaSite" id="DME_0000699101-mRNA-1">
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        <property type="gene ID" value="DME_0000699101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195736at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
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        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCATNINFAMLY"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
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        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000699101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="658" mass="73173" checksum="E6F600A5EA6CC239" modified="2016-06-08" version="2">MGDPYLQTRYDRLRLIMFPELCDDLEPNEEMLSGRTSIVQQLIDPTRLLKTAIVELISLQDESELTTKAIPELIKLLGDRDEMVVLRAAHMVHLLSKESKSGTAIANNPTLIAALCSAIRFDNESIRRDTLAALSHISEYEQGRMHLFRSGGIPELVKMLSVSINAVRHYAITTLHNLLLYMDSAKQETRNFGGLEAMTPLLHEHNPKFLALLADSLYLIMLDHAQSKLSFLSMNGPASLISLLDSYRQYPKLVYTIVRCIRAISVCPQNENVLISLGALQLLGDFIDDVEERTQIAVLCAIRNLSDAATNETNIAPLIIRLLNVIAMGDESLAACATGILSNLTCNNVRNKQTVCVNRGMDILCSALDRFTKIEEITEPTLCALRHCTARHPLASQAQSDIRLSQNLPVILDLLSTMRAPIVKAALGLIRNLALLPANFYSLNHETTSKGDSVVTLAMDVLGRAGAQLRQDPEAAADGVAMRELVEGAVSALHQLANDPSIANIMLRDHPFIEMLIKLLSSEHVYANDDELLQRELLGLIYQLSKSVEGSHQLDIHGSTPFLLDALHSKNKAVATYASVILKNLQRDKPVMYREELETEIESAINEGDEWMHDGLEPELFAEMYQESGVDRLDHHSPWQPPPYQTNGQNPSWFDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI43</accession>
    <name>A0A0N4UI43_DRAME</name>
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        <submittedName>
            <fullName evidence="4">DUF362 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9926</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI43"/>
    <dbReference type="WBParaSite" id="DME_0000725801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000725801-mRNA-1"/>
        <property type="gene ID" value="DME_0000725801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000725801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10188" checksum="B664449CE2A4BEBD" modified="2015-12-09" version="1">MAIAINIEERSAMLGIPNRGNENLDFYMGPKPSIFCNELKRRSLIEYSTTGRIFIDGKPTDPQTCEESWNFLLKSTITGDFTRRSLAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI61</accession>
    <name>A0A0N4UI61_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1696</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI61"/>
    <dbReference type="WBParaSite" id="DME_0000727801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000727801-mRNA-1"/>
        <property type="gene ID" value="DME_0000727801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000727801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16122" checksum="2C934E071208184B" modified="2015-12-09" version="1">MERLENFFGKGDFDFEEVPEEEVPSFYREVLIDSNYHRNRLLPTVVRELYASFKEDESASSPNLLPFDRLTPPVTPEHVKCRAAVFSKVTSESNESSSDHSGNPEISSEAPQAIATDNLEEKQEQISSMRWYEYNEHAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI90</accession>
    <name>A0A0N4UI90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9947</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI90"/>
    <dbReference type="STRING" id="318479.A0A0N4UI90"/>
    <dbReference type="WBParaSite" id="DME_0000731101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000731101-mRNA-1"/>
        <property type="gene ID" value="DME_0000731101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000731101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="899" mass="101810" checksum="30CAA71B3CBC4671" modified="2015-12-09" version="1">MLEEDLDKLEMRFFSQVKADCIRNVSIIAHVDHGKTSLADCLISSNGLISARMAGKMRYLDNREDEQIRGITMKTSVISLLYKSIIVNLIDSPGHVDFSGEVSAALFISDVALLLIDVVEGICSQTEFLLRQSIRLNLDLILVFNKFDRLFVELKKTTAEAYSYIHRLMEQVNSCISQIISGTLVELENWKNMDETEQSHYFSFDNDNVVFASALHGYGFSLTDFATIWSPKLNIPVDELRKNLFTNCYISKGKIKPNASQNGKKNIFEQLVLQPLWEIHKCGLIDNDLDKLKMFASKMDIKLKSKRIVEAFDEFMRNWIPLSNACFHAIQQSQSPLTSFTRPNRLSSIGINTGNKLCKAISSCDENDIAVVFVAKILSHGENILAICRILSGSVKIGDNLFIIGDRRKVHSNERIDTKINGIFMLTSREKFPATQARAGIVCALEIEGQSFASVLCSEYIEESIKLPHEIDPLVRVLLHSEGTTDEWNELREKLRHLCALDSSIRVIEQKTGELALLAAGEVHLQKCLTDLFDMGQTNVKVSEPTVSFMETIIPSNSNVSLDNQIVNCNIRGDILTIALRAVPLPLEFTKLLERTTETLRDLRQGLFETKEVQLFRQKLLSEGVKWLKALRGTWWSRQSEQFLRLLVERIWAFGPPQAMCNVLFNAVTEYDRPLIWESNFIGDKSEQTYYQLFDQSIRTGFDLAVLAGPLCEEPMWGVAIVVESWTCKGYDDPGLSGSLITAMKNSCRAALNKQSLRLMSAMYKCNIQTNSNALGKVHAVLSQRQARITHEDVNQATGLFVVEAFLPIIESFSFCEQLRKKTSGLALGQLEFSHWEILPEDPFWEPTTEDEVELYGVKADSLNKVRTYVDSLRKRKGLLIDEPIVLNANKQRNLKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIB2</accession>
    <name>A0A0N4UIB2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9972</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIB2"/>
    <dbReference type="WBParaSite" id="DME_0000733601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000733601-mRNA-1"/>
        <property type="gene ID" value="DME_0000733601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5807587at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000733601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52415" checksum="3A15827E8A3A2CC3" modified="2015-12-09" version="1">MDDKHCYAISCAFVESSCSWNHGPKWLRLDGNLVMDKEGEDMVTSDLFTVPRDASLEMDIWMSNGVHFTVTEIVPTAELVLWSKYGLYGEGGWRRLRIPIRSFRSPTKIQLKANVPINNFITISNTKLIDKDGNEIGCEPKLFSIIPIVPNKSTSVEPERLTAYQKTKGEDNTGVLSTTASIKREKIEIDPSLPFALLQITSRPLIRPQLTTQRTWIFGEKSLSWNSIPTESIANNSSSLNFFENASTKLNGGQVLNSLLTFSKEDQSEMHELNGIFKSSDIFRALSKPINPNIGINHSNSQPKLSDLATLLSHIGDQPFMETHFHQFAKQFGLEKLSNQQLIKQLKSKEEMTSTILPLTTLIYHKETKVRPIKPVNAPTINQLAKKPKKKDLKFSIEGFSEDNTILTQLLQQGLSSLTSNDRSSTNNDILKKLALFLPHPPPHVDFHSPFTQQNLDFIIQNANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIH2</accession>
    <name>A0A0N4UIH2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CTD nuclear envelope phosphatase 1 homolog</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine/threonine-protein phosphatase dullard homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10043</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Dullard family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIH2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIH2"/>
    <dbReference type="WBParaSite" id="DME_0000740501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000740501-mRNA-1"/>
        <property type="gene ID" value="DME_0000740501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044091">
        <property type="term" value="P:membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000044">
        <property type="entry name" value="CTD nuclear envelope phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="70"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000740501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30062" checksum="3588E899AD87CAD8" modified="2015-12-09" version="1">MKKRKNYSKMERNTLIRGLQTIFATLCFYIAGVINCISFATKRQFRNFRKRQVVRYQRIPLSPLTAHRLSVIRRKIFVLDLDETLIHSHHDGIFRPMVKPGTPPDFILRVNIDRHPVRFFVHCRPHVEYFLSMVSEWFDLVIFTASMEIYGSSVADKLDNGKGILQRRYFRQHCTVDYGGYTKDLSAVHADLSSIFILDNSPGAYRKFPQNAIPIRSWFSDPTDTCLLSLLPFLDALRFTSDVRSILSRNQQLQQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIN0</accession>
    <name>A0A0N4UIN0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1758</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIN0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIN0"/>
    <dbReference type="WBParaSite" id="DME_0000746501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000746501-mRNA-1"/>
        <property type="gene ID" value="DME_0000746501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000020">
        <property type="entry name" value="Glutathione S-transferase P 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003082">
        <property type="entry name" value="GST_pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF141">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01268">
        <property type="entry name" value="GSTRNSFRASEP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="79"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000746501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23779" checksum="A54C53C76B88DBC1" modified="2015-12-09" version="1">MFGMKGNLHLGLAEQIRLLLNDNEIPFEDHRIPKTEWEKFKPQFHFGQVPCLFEDGHQIVQTGAIMRHLARKFNLYGTNENEATFADMFYEGIRDLHNKYTKMIYLAYETEKDSFIETILPEELAKFEKLLKTHGNGNGFILGDKICFSDYALFEELDIMEILDSNSLNNFPHLKAYHQRMHDRPNIKVFDDMDFLVKVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJC1</accession>
    <name>A0A0N4UJC1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10158</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via cytoplasmic region) with ILK.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJC1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJC1"/>
    <dbReference type="WBParaSite" id="DME_0000774801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000774801-mRNA-1"/>
        <property type="gene ID" value="DME_0000774801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="4">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000774801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22665" checksum="C3045CB95E37CADF" modified="2015-12-09" version="1">MILKYFTSDPICELHVAYEEQDKDEYVKEGCPKCIFFRVEGFHSAHIYLKLRLDLFTFQTIPRKVLEECTQLTLSTCRFNREKKLNVLYTPWENLVHLPEMGSGHIAFRNSAGVRSIYDIEFSEEILNRIRSSDSFVDLKAKKTQHSRDYASRQYEASLDIVSRMTEGQKQTARDIIHKMLTQDTREDREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI0</accession>
    <name>A0A0N4UJI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH_hydro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10189</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI0"/>
    <dbReference type="WBParaSite" id="DME_0000781901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000781901-mRNA-1"/>
        <property type="gene ID" value="DME_0000781901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000781901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26675" checksum="2B6C81CC8D344C7A" modified="2015-12-09" version="1">MYLSDVEVTDVTSDTERIDGAIFMSKANKAGCSSLIVFGDSLSDDGIEFGDNSYGFERNCNGPVWPEYLSQLLSCKKYINYAYSGAKSGYDNVYFTGWSGLLWQFETFINNTPLIPTGMIIIMNIIDPTDAPGMQSAELGSGLIDDVSQLVVNTNSRINKMIINHKSMSPKVALFDLNSILLDLTKYLNKNSQFTYQKQNFTLREIFDYAYYDLWNPTTFVHYNIALKLIKLIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK04</accession>
    <name>A0A0N4UK04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CNDH2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2147</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK04"/>
    <dbReference type="STRING" id="318479.A0A0N4UK04"/>
    <dbReference type="WBParaSite" id="DME_0000802201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000802201-mRNA-1"/>
        <property type="gene ID" value="DME_0000802201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000802201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43780" checksum="14D445A1FEA52948" modified="2015-12-09" version="1">MFIRRIKSHLFLLPCKNGSRIAEVRFTFCSMRNAYGLRFLYLFFNIPFLYLQRETLLGQLKRNEREIELSCKELNIYEETAEADYNQFIEALTAKRRIAVEKIEPLTTGGNINVQLPLDAGQPISSAAYDLNDGYNSVPAYSSKNTSTIINENFQNDTNLSSDLNTVPKMSSSSDENVNKMVAVYEEDYSVDDHEHGSESSRKSSRTNKIFSDFILEKKPPDTPIAYRVQLFESRPVSPIFNPHKNVSIVHPEIDDIMQVTFTSDDLDAWLGDPVTLATDEFEIKDDNSDARNCDNNPLVTSIPVDSDSDGVIESCGRRVDLLSNDSSAAIMTKAAQRVRSEKFKKTSEEKNKSSKKKNNRKKDKKSGFIIDNKVKTKDPNMYDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKK3</accession>
    <name>A0A0N4UKK3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2303</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKK3"/>
    <dbReference type="STRING" id="318479.A0A0N4UKK3"/>
    <dbReference type="WBParaSite" id="DME_0000827301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000827301-mRNA-1"/>
        <property type="gene ID" value="DME_0000827301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000827301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="59608" checksum="4E7DA17790197019" modified="2015-12-09" version="1">MLSGDASLSLVRLFLISCLRIYMLCILFFPLFSSYPFVKRSEKLYTWWWHALLWSVQRSGPTIIKLCQWASTRRDLFSKEFCDNMASLHIKTTHSQWKFSKNMLNELFGSSVWESFLLSIEKDPIGSGCVAQVNKIFFSIIIVYKAKLDLLTLKKKTGVNLLETNKERFIDVAIKVAKPGIRDQIEFDLSILRVIAHIAEKFIPCLVFLNPVLCLGQFETVLKRQIDLRNEAKALDVRFSNNFDLKTTGVCFPSALLYSRNVIIETFEEGIYINHLVTEQHQVIKNALFVISIPSSFVPAIRKRVALTGIRALLKMIFVDNFVHGDLHPGNILVRFGDRIDELEKMSYFKTFLSWTIEFIRENFGFMHQPAIRLFKIEKYSNEPTLVVLDPGIAIEQAPKNLHNLRALFRAVIEKRGKDVGELLLSQAPQQDCLDPILFCSEVDDLVQRARSINSLKKFNISELLNELFSIVSRHHVYLDTSFTTVILAVMVLEGFGRSLDPELDLFKCARPYLLSVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKQ6</accession>
    <name>A0A0N4UKQ6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10351</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKQ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UKQ6"/>
    <dbReference type="WBParaSite" id="DME_0000833401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000833401-mRNA-1"/>
        <property type="gene ID" value="DME_0000833401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF114">
        <property type="entry name" value="PROTEIN MOM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000833401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30528" checksum="CBE63E3BA46D79F6" modified="2015-12-09" version="1">MVWFLPYKANVTFDDSDTACTLLLSLTKKQRRLCIKHPYAITYIISALKAAKSECRNQFKDNLWNCSIVEKEFLASQLKRATRETAYIFALSSASVSRVIARACSEGALTSCSCGAQPRRIPKHFIWSGCSHNIRYANKFGRKFFDEVELIAANDARAMVNLHNNRVGRRILSKNMRRKCKCHGLSGSCIVKTCWKVVPELIVQTADNGNALILKTGPRSLRTGRFVGFSKKMVARNELVFLNDSPDYCLIDEINGLKGSQGRECNQNCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULU0</accession>
    <name>A0A0N4ULU0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytosulfokine-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2672</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULU0"/>
    <dbReference type="WBParaSite" id="DME_0000878101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878101-mRNA-1"/>
        <property type="gene ID" value="DME_0000878101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041082231" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8879" checksum="8E06497728610C82" modified="2015-12-09" version="1">MSTARVVFVVLTFFFLSSVDAANYNPIDDCFTLVPVQNVQNNNKKRPSIPPSACHDTDLGLCYELFKLDEPTIQNNLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULX7</accession>
    <name>A0A0N4ULX7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULX7"/>
    <dbReference type="WBParaSite" id="DME_0000882401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000882401-mRNA-1"/>
        <property type="gene ID" value="DME_0000882401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000882401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18447" checksum="4177669FA60C0C92" modified="2015-12-09" version="1">MILDLRWNNTGSCYGNSLKAQALKKSCDCSCKIVHHTRIQTCCRRVGQKEMAFCLPLCGYNTTVQELSTGLGYKCVSQLTTWAYCAADANDNTECCRNKGVHKDCLSFCKGDVPTCDLQSILSYQPCLKDIENIIKCQMENLSAKPRYDPDWSARCEWDGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM18</accession>
    <name>A0A0N4UM18_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10508</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM18"/>
    <dbReference type="STRING" id="318479.A0A0N4UM18"/>
    <dbReference type="WBParaSite" id="DME_0000887001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000887001-mRNA-1"/>
        <property type="gene ID" value="DME_0000887001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120383at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052118">
        <property type="entry name" value="Rho-GAP_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="484"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000887001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="710" mass="79593" checksum="D6CA1A73AE52953F" modified="2016-06-08" version="2">MAKQYPQSKELSKQRGQATCATSYVPVKNPKQRFAQSPLLIDNKGDSLMETVSRTALLPPPKILPATIRRTDSFGATSQPLQPHPAYTCSIPRSHPLRAIPLQSYPCSSTQTQASYSGTTPSNFSQLPQTQMPYGSTPFSSSQKSMSDVGYSMHHSLCSPIFDRKIDRNLGWHSVDLAYKSNSLPRRHAASATAPRSVKWRNDVIGGTNAVDVESDGAISAPEMTFSPTLTNSYISHRGSQFQSSSHCRTIDDIFSAQEYRRWAGVDPPSKSYDRQSRWSHTFGERLGASIRSSSLPSRSILSQPGRFTTSHERGDLFDRLHVSPLMNRRVPLRPAGPGFDIDTPLNVTSLTGLLVIQDKHPEMAPHYAILSTIIEGRGLKMPERQKAFTEEMYCVVEVNEVHRARTGVSTAEQKFRWQETHKLCHKGSLKLLEAFIVDRLNGDRMFALNLEPKGQLIVRVAFHNMTVAYRRTVNCRYDGVFGVPLQRLIARDRRETPLVLTRLLQEIERRGVDYSGLYILVGSVEKKRMLRDELEFNVEKAELSVNAVPDTNVLTCLVKDFLRELPEPLISISIYGMLVDALAVSLPNDPQDNRQLLLRVIDCLPTPNKNTLIQIMDHLKMVATSEHHNGLTSARLMTIFGCLIFCSCELPADGYQLKETINPMDADQAARTFSMLFDIWPARMRVKAAVQTTPIQNSNQILCPNLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM58</accession>
    <name>A0A0N4UM58_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF982 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2761</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM58"/>
    <dbReference type="STRING" id="318479.A0A0N4UM58"/>
    <dbReference type="WBParaSite" id="DME_0000891501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000891501-mRNA-1"/>
        <property type="gene ID" value="DME_0000891501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810331at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000891501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11256" checksum="2B1CD199717596E0" modified="2015-12-09" version="1">MPGIQYYDGKKINIPISHEAGIELHEKWTHQGLSSLMSAIASKISRDLNEFHRNKLFKCSKKAENVHEHARCVVAALDAQEARKRFAKIRSPFRLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM60</accession>
    <name>A0A0N4UM60_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2763</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM60"/>
    <dbReference type="STRING" id="318479.A0A0N4UM60"/>
    <dbReference type="WBParaSite" id="DME_0000891701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000891701-mRNA-1"/>
        <property type="gene ID" value="DME_0000891701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867004at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00052">
        <property type="entry name" value="nudix-type nucleoside diphosphatase, YffH/AdpP family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF15">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000891701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17000" checksum="D4FB4CAD6F9D8FA4" modified="2015-12-09" version="1">MVLGHDSAACVLYHKNKKSFLFVRQFRPAVFVAKIRSMPENINKSLKEINWTTYPINIGKTIELCAGIIDKPNLDAKRHIHEEIIEECGYNVPIDSIKHIKKLIAGVGSSGSQQDIFFAEIDESMRVSDGGGIGEESIEKVFLCCEAFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM85</accession>
    <name>A0A0N4UM85_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphorylase kinase</fullName>
            <ecNumber evidence="3">2.7.11.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10555</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + phosphorylase b = 2 ADP + phosphorylase a.</text>
            <dbReference type="EC" id="2.7.11.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.19" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001224">
        <property type="protein sequence ID" value="VDN60582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM85"/>
    <dbReference type="STRING" id="318479.A0A0N4UM85"/>
    <dbReference type="WBParaSite" id="DME_0000894701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000894701-mRNA-1"/>
        <property type="gene ID" value="DME_0000894701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419455at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004689">
        <property type="term" value="F:phosphorylase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000138">
        <property type="entry name" value="Phosphorylase b kinase gamma catalytic chain, liver/testis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002291">
        <property type="entry name" value="Phosph_kin_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01049">
        <property type="entry name" value="PHOSPHBKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000894701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="45112" checksum="7C5FE080A123E84A" modified="2015-12-09" version="1">MEEEGSGFYSAYEAKEVLGRGLASTVRKCVEKGTGSMFAVKIVDISTERQPEQEAHRLLKETINEVNLLKQLSGHPHIINIHDFYQTPTFLFAVFEMAPKGELFDLLNKSVTTSEKKARRIMGQLFDGVAFMHERNIVHRDLKLENILCIDDERVVISDFGFAVQLAENQKLRELMGTPGYLAPETLRCQMYEDAEGYGVEVDVWALGVILYTLLAGYAPFYHRRQMLMLRLIQEGKYEFRPEQWAQITQEAKDLIRNLLVVDVSKRYTAAMCLEHPWMKIARMDSVRKITEPSDALKEHYRNLWRHAIILVRFFIRLTNVKYLKLLVDYDELCKRPFRDRDIRHESEAAVFAVYGHWVNRGFYYSRDMLFANKPRPKFKSVVVVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN17</accession>
    <name>A0A0N4UN17_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10637</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001230">
        <property type="protein sequence ID" value="VDN60664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN17"/>
    <dbReference type="STRING" id="318479.A0A0N4UN17"/>
    <dbReference type="WBParaSite" id="DME_0000928001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000928001-mRNA-1"/>
        <property type="gene ID" value="DME_0000928001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000068">
        <property type="entry name" value="Orthodenticle homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000928001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29404" checksum="9C75416668D0F7AB" modified="2015-12-09" version="1">MSYLPSVSVSGAAAAVNMSSAANMAAAAYFKNGTYGGTHMTGAALSFTPPAHNFLPASMGYISGTLADCQSASMTAWGTGQASRKQRRERTTFTRLQLEVLESYFSKTRYPDIFIREEISLKIQLPESRVQVWFKNRRAKARQQKKIAKQEPHTSGLCINNSGPTDPNTQSDSLNSNNDTIKAEDESEPAVVVQRSTVSPTEIDAAKITAFPATYLGTISPSSAYSTQPPFPQGYGYAGYQTAVPTPIDYFQYPANAATYGASDAWKFINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN37</accession>
    <name>A0A0N4UN37_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3023</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000097">
        <property type="protein sequence ID" value="VDN53050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN37"/>
    <dbReference type="WBParaSite" id="DME_0000930101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000930101-mRNA-1"/>
        <property type="gene ID" value="DME_0000930101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000930101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33939" checksum="0775BB1F76E039B6" modified="2015-12-09" version="1">MLSNDQLRYSTTPISLSALTERLSQAVGIGNNGSIITAMFSSSSPNALCNSSQSVNSELIQPTIAFKRQSLKRPMIFSEHFEVPKPKRRMEQMNDKLKNFHISLNSNITQYEWQRRQKTETFEELEERLMEGGKGKIRQHYWILWETNLRQWQVIITKDEEDMRATRLKESDDEMDSCEPSTSQNQSDDAEISLKLSAELQQYLKRSRDAPVIVENPTSAVVPYIPADPYQDPSMHGRIKEVSSDPYIHNIYEAVFSFVTFPEEDRAESPIVNAYTSSIEIKELESSEDEPMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNA4</accession>
    <name>A0A0N4UNA4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3088</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000103">
        <property type="protein sequence ID" value="VDN53115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNA4"/>
    <dbReference type="WBParaSite" id="DME_0000937701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000937701-mRNA-1"/>
        <property type="gene ID" value="DME_0000937701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874634at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000937701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36307" checksum="FC274601B064A0E5" modified="2015-12-09" version="1">MNNRDDSMIKRQRKKKLQSIIVDKPNYATFEVRFFVLLLLDRFFLALREGAGASPDSETLARRARWRAAQPERFVPPCDPHTLDIRNFQLFGNGYDSPLNSPLYLSSPPRFEAVDFFPETFRINLVRERNEIFMKSSVHISYKEYLSLIQDIGRLINCRLRLVNTIFKGSSLAPDKNDLETFAKVIRGLSDVWYMFTTLFQMSYLSTVICIPDDVFHEMIRAAKPLQAAVQDTPIDYHCIPNWNYAIGSSSGMNLYSPQFSICHIPMIKICSYCLAIEKYPFDHTNKECVELARLRPCRLCGASGIDNHTISLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNS7</accession>
    <name>A0A0N4UNS7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3246</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000117">
        <property type="protein sequence ID" value="VDN53273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNS7"/>
    <dbReference type="WBParaSite" id="DME_0000957901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000957901-mRNA-1"/>
        <property type="gene ID" value="DME_0000957901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876:SF1">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000957901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17709" checksum="FCA598F926326FA1" modified="2015-12-09" version="1">MEPFGKVVLADRMQCNQWQWMCRNGECIAQYDYCNGIAQCSDGSDEMAGCETRPMAINYAGVFREDQMLKATKVPLPVATTTTLRSPFGFNSERLQDYWIMIFLVSTFMIVALSALYYRSYRMKAIRNRAFGLRKTDIAEEDEDDLLISSLYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNT6</accession>
    <name>A0A0N4UNT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3258</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000117">
        <property type="protein sequence ID" value="VDN53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNT6"/>
    <dbReference type="STRING" id="318479.A0A0N4UNT6"/>
    <dbReference type="WBParaSite" id="DME_0000959101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000959101-mRNA-1"/>
        <property type="gene ID" value="DME_0000959101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000959101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14325" checksum="119F0B3CFD35B5D9" modified="2015-12-09" version="1">MSSGNRTPDPLVFSTPIIKTPISDKISLPMSQQGRPCGFFEELFFRCMEAYGARLGRIYCDLENRDFRECLTSDKQRKRINAIRNERRRKYRNGEIAEAFEKNFPEFGQYKPDYFSHNRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP90</accession>
    <name>A0A0N4UP90_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3376</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP90"/>
    <dbReference type="STRING" id="318479.A0A0N4UP90"/>
    <dbReference type="WBParaSite" id="DME_0000976001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000976001-mRNA-1"/>
        <property type="gene ID" value="DME_0000976001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000976001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="33362" checksum="CE9F21A68D14F75F" modified="2015-12-09" version="1">MIIYGRFASSLVLAEHGDGKLNMVTLNAVTAASKLGDVSVLVTGADMKSIAQQLTKVEHVKRVIMAEDEKLKVQLPELVTNVVLASQKRFGFSSIIAGSSTFGRGIIPRVAAKLDVSPISDITFIHSENTFSRPIYAGSAICKVKSLASVKLITVRGTAFSPANIGGGSGAIEIAPSADLDFAKTEFLSQDVSNSGRPDLQTAKIVVSGGRGVGSSENFKLIYDLAHKLNGGVGASRAAVDAGYAPNDLQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPDAPIFQVADFGLKADLFQAIPELIKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPM9</accession>
    <name>A0A0N4UPM9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3471</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000137">
        <property type="protein sequence ID" value="VDN53498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPM9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPM9"/>
    <dbReference type="WBParaSite" id="DME_0000992301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000992301-mRNA-1"/>
        <property type="gene ID" value="DME_0000992301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970722at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000992301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15185" checksum="3ABA7434110E8DEC" modified="2015-12-09" version="1">ITHRICNQQVIIQKIYLNLFSIYLFISFIYFSVCKFIWQSNMIAGYNSSPSPLGMASGSRIGADSDDSTRKRQVRLLKNREAAKECRRKKKEYVKCLENRVAVLENQNKALIEELKTLKELYCRKEKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ27</accession>
    <name>A0A0N4UQ27_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3613</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000157">
        <property type="protein sequence ID" value="VDN53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ27"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ27"/>
    <dbReference type="WBParaSite" id="DME_0001009101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001009101-mRNA-1"/>
        <property type="gene ID" value="DME_0001009101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-rubredoxin oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="244"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001009101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37657" checksum="BB0D2E5FC888FECE" modified="2015-12-09" version="1">MQNELYELKNIEIIWAVKHSSISATFFDECAAEFFKPMLISGFAPETETSTTTTSKRYNITIDKDGFQTSEATRGCALGPDWAQDFNISGRLKERSVIIIYNVELESILSDDQVDQSYLLADNYLSNGQWPLFIKLSDNQVIGCDLLIQATGVLPNSNFWKQECDQLHLASDGGILVDDHMRTSIEYVYACGDVCAAGWNWSKHWLQMRLWTQAYQMGTYCGRSMVLSDVPLDFCFELFTHVTNFFGFKVIFLGRFNGDGVEKPWHLLLRINANKQYIKLIVKDGRIQGAILVGETNLEETIENLILNQIDISSVEEGLLDPEIDIDDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ87</accession>
    <name>A0A0N4UQ87_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3678</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000166">
        <property type="protein sequence ID" value="VDN53705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ87"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ87"/>
    <dbReference type="WBParaSite" id="DME_0001016201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001016201-mRNA-1"/>
        <property type="gene ID" value="DME_0001016201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
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    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001016201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40229" checksum="8C4D5FF72A75D3C4" modified="2016-06-08" version="2">MQFSILGMELVGPSKRKVASVVDGIFFALGQVFLGVMAYFFRNYQYLQLVISLPSVMFLSYWWLFITQQVFRLVPESARWLISLKRFEEADVILQRAAKINGKKLPEAWWEQIESLDDSKSTAKDQMHKRYNILDLFRTRQIRIRTLACLFIWPVVSMIYYGVSMKTDFLGGDFYFTFIIGGLSEIPALLLVYLILDRVGRKIVLSAGYFIAAFCILTNLIIPSSAHWSINIVQFLLAKAAITSSYAVIYTITPELFPTVIRNIAMGCCSMIARIGAISASYISMWIVEYIGKWAMIIPFGSFALAAGFVVLFFIPETMGKPLPETINDIERKQSIDAEAMIMTVNLEREQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQS1</accession>
    <name>A0A0N4UQS1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA-ATPase_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3846</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000200">
        <property type="protein sequence ID" value="VDN53873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQS1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQS1"/>
    <dbReference type="WBParaSite" id="DME_0001037601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001037601-mRNA-1"/>
        <property type="gene ID" value="DME_0001037601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001037601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9780" checksum="E7F7C4D12D0E4392" modified="2015-12-09" version="1">MLSLIGYPEFIYNDAELDKFYSELNIYANDSYITMNGKILQWTQDKNFRKLLEPTDRAEFVISSSVVNAFYTQTANTISIFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR31</accession>
    <name>A0A0N4UR31_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATG11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3948</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000228">
        <property type="protein sequence ID" value="VDN53975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UR31"/>
    <dbReference type="WBParaSite" id="DME_0001049901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001049901-mRNA-1"/>
        <property type="gene ID" value="DME_0001049901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:autophagy of mitochondrion"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
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        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001049901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16107" checksum="A1E109FE39149FE2" modified="2015-12-09" version="1">MSSFTFSAHRSKKATYCAIEPDFTILSKKNACVETIITMRDMRRMISIENIQKDSVVFLTWSDLHKAFKLFSVSPMLYFVKESSLRRIGIVLENTDSRPNCLIAVVASMECCQIRKSSNRSGYGLAMGERFYRVEVDFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URB4</accession>
    <name>A0A0N4URB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sialomucin core protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4017</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000248">
        <property type="protein sequence ID" value="VDN54044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URB4"/>
    <dbReference type="WBParaSite" id="DME_0001058901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001058901-mRNA-1"/>
        <property type="gene ID" value="DME_0001058901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041120432" evidence="2">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001058901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13556" checksum="D2D430AB247BEB0E" modified="2016-06-08" version="2">MWSLFFLIYLAVCFAADPISIDSTLTTSAANTSESTKNDSSTAPEILTSTVLPSSSSTTTSTTTGENITMTIPENMTTTVAPPPSKLRTGQFFGGIILGMILMVFLTVVYKCWQLRRSTTGYEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URK7</accession>
    <name>A0A0N4URK7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EHD_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000291">
        <property type="protein sequence ID" value="VDN54127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URK7"/>
    <dbReference type="WBParaSite" id="DME_0001068901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001068901-mRNA-1"/>
        <property type="gene ID" value="DME_0001068901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001068901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16852" checksum="A5BF218D79F685FC" modified="2015-12-09" version="1">MRCVQHSEQGVVSVALIQANSHWRSLYNRPSPFNCLPCNFRSFCFEHSSKVSAKTCEQSKKDEIDAVRKKVAELNEYFSQYIDEYYEEVLPLEQPGVAKVKGNIFIHIITPKLYTKYESLWSGYDDEIPDDPDFMLPKSTDLILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URR2</accession>
    <name>A0A0N4URR2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4147</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000330">
        <property type="protein sequence ID" value="VDN54174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URR2"/>
    <dbReference type="WBParaSite" id="DME_0001074401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001074401-mRNA-1"/>
        <property type="gene ID" value="DME_0001074401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039265" evidence="1">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001074401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13223" checksum="06EDDB5E8476194A" modified="2015-12-09" version="1">MSIVAYMKIILLAILATSAFKNYSIEFKSVNFLLRLFLLDFFDEIGRTLDANSDRRLIFGSTCVSQLCKESSEFSLKNLLGLLGFALLEMAYRFFEWNSFTMEALEVPNVLRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US20</accession>
    <name>A0A0N4US20_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4249</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000477">
        <property type="protein sequence ID" value="VDN54276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US20"/>
    <dbReference type="WBParaSite" id="DME_0001085201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001085201-mRNA-1"/>
        <property type="gene ID" value="DME_0001085201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001085201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16951" checksum="0A41CED165F5351E" modified="2015-12-09" version="1">MVFRNIKLRKDGQFLGLMLIESFPALGRSWDLFECSGKAFNMNQMSWLKQCQFGPRIAKYSVSCGYRPENFDSSARIKREKIEDMLNIIRKESLSCDPRSIGLIFAGPKATPEDFQISNFSGIEYSQFENVELKAHTYKLWQMDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US93</accession>
    <name>A0A0N4US93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4317</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000717">
        <property type="protein sequence ID" value="VDN54344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US93"/>
    <dbReference type="STRING" id="318479.A0A0N4US93"/>
    <dbReference type="WBParaSite" id="DME_0001092501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001092501-mRNA-1"/>
        <property type="gene ID" value="DME_0001092501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="14">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0001092501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17815" checksum="85AB8F6D95400F11" modified="2015-12-09" version="1">VAKITVCVIAFLLFGFVFHSTWVTTASYSNPTIILTGQQDGRNIRQDDMREAYYWLRKNTKQDSKIATWWDIGYHITAIANRTAFIDGNTWNNTHIAQISLALVSNEEEGYQILKRLDADYVALTFGGYNAHETDGSFIFYEFLYYRNCLSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q428</accession>
    <name>A0A158Q428_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7884</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q428"/>
    <dbReference type="WBParaSite" id="DME_0000387901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000387901-mRNA-1"/>
        <property type="gene ID" value="DME_0000387901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870446at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF11">
        <property type="entry name" value="PROTEIN CBG14497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000387901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25034" checksum="BD90E3D2524118F7" modified="2016-06-08" version="1">MLKNSRPFPIYEQVVKMMNGRMRSMLIRNQAANGMISDTLPKSVQFDESSDNYRCFCNAFHVKTGALLISGIEDNYVNGAFLASVIGVALSLLVIFLLGVGVARNYAILLIPHLIMQLLVILLLLVCIMNGTIAFLTKSTLFYKLLHAAAFNEPPDKNTVALDLETSVKIYVVFAVYMLTLILEVWFITIIYNCYQYLIERRAYMKYCLAFSTPMKTLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5K8</accession>
    <name>A0A158Q5K8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A2M_N_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1917</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5K8"/>
    <dbReference type="STRING" id="318479.A0A158Q5K8"/>
    <dbReference type="WBParaSite" id="DME_0000765001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000765001-mRNA-1"/>
        <property type="gene ID" value="DME_0000765001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF175">
        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000765001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28596" checksum="99101A66B7EB82A0" modified="2016-06-08" version="1">MAVINLQPPRNCSSARVEAQYDRSGQDNFTSAVIYSSLYIEASKSPSNSYLQLIPDHDGAIDAGKTLSFTVKATESVSIIAYQVIARGSVVLTQQLSVNGDLATVTFAATPQMAPKSRLVVYTVRPSNQEILVDVSDFRVDGLFRNNVSLVIDRNTAEPGEKVKFTVKADPESYVGIYAIDQSVEHDIGQYDTTDGVLNARPWEAAFRRKRSIWYPWCGVGGKDAETIFEDKPIRKMSGFGLETRRFEFGQSTGSAFSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5P7</accession>
    <name>A0A158Q5P7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2052</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5P7"/>
    <dbReference type="STRING" id="318479.A0A158Q5P7"/>
    <dbReference type="WBParaSite" id="DME_0000792701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000792701-mRNA-1"/>
        <property type="gene ID" value="DME_0000792701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052812">
        <property type="entry name" value="Plant_DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272:SF3">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000792701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43373" checksum="E3F0DE7173F40EF4" modified="2016-06-08" version="1">MSRASSSCKLNCKEDDYYEILNVSKNASEQQIKNSYRKLALKYHPDRNPGDQKAAEHFKKISIAYAVLSDPNKRRQYDLNGPSGAIIDFEGFDISEIGSVGRVFGALFSKIGVPIPTQIGPKVLTQARSLCEGTPTDAKYSVLQEGVQYDGSVAKQEAAFFKITMREEWQKNGLMIMCKSPQMSKFKLVLFDKEGGVRMIQESNKRKGCTAAAIYFVPFDRANLSEFIPMKFYMEDKDTPLSFHLLDTLETVGAQQLDARDHFLCVYGDNWIKDVRFQLRFLPLNDSLSSKNIIQDLTEVERSLLLAKKEMAQFQIEYTEAIRKYKEVNERLKTETETINGLLKKRDQDYDELERESASVFVNQRSPQNQSKGFLSNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Q5</accession>
    <name>A0A158Q5Q5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2097</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Q5"/>
    <dbReference type="STRING" id="318479.A0A158Q5Q5"/>
    <dbReference type="WBParaSite" id="DME_0000797201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000797201-mRNA-1"/>
        <property type="gene ID" value="DME_0000797201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="68"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000797201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35689" checksum="1CE4A1E4E4D14330" modified="2016-06-08" version="1">MIMFIKRETRIFFEFQEEEFKQRLALTDAAPYSDDEIAISRRNRIDYSKKVTMEMAKSGKAGREIRVYADGIYDLFHYGHANQLRQAKNAFPNVYLIVGVCGDANTHKYKGRTVTSEDERYEAVRHCRYVDEVYRDAPWYCSVEFLKNLKVDFIAHDALPYVAPGEEDLYEKFRREGMFVETQRTEGVSTSDVVCRIIRDYDKYVRRNLRRGYTAKELNVGFLTARKYQLQDKVDSFKQKSIELLQNWKMKSDDFIRDFLETFHKDGGLNSMGSRLRELVSRSPSPTYDYEEQAEEDTFGAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5R5</accession>
    <name>A0A158Q5R5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2162</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5R5"/>
    <dbReference type="STRING" id="318479.A0A158Q5R5"/>
    <dbReference type="WBParaSite" id="DME_0000803701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000803701-mRNA-1"/>
        <property type="gene ID" value="DME_0000803701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000803701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="668" mass="77827" checksum="9A98F93C8E6F3E60" modified="2016-06-08" version="1">MIYKLFTFHKISFFMNLDEPIISAFLLYIVNIMEHLTPLIMHEFIVKNDDYRKEALVKIYVSWIVLFNYARRMKLEDNLESSTLSILLNFVRSVLSSPEGNRETILDDNTDGDQEHDEIALADLLEPDSQRLYSVQMMTRNCTRFHFFVCHSCAGCWIHLRCVRNKLKQFVSFMQKGFNKQILIVWWEDMHWLLIIIGSIYAIIDYELCDFPYALESFIDADMEKYGEDSNIITNYIINCIQNADSFDSVDLPIFAQTIAMVSAWASIEYRVLEELNIELTSPELTRTTMWCISRLYGAMSDDTVDRNSRMRLMKRDRGFANFIIEFLLRKSFAIFNKLSGETKLCEDSIEFLGTLMKRCALEIASGDVLFNCLSTVRYDNFPSRASIIKALAIISDSVVASDEIKMPLQEKIFHLILEPLRNEFLTLDKSPSSESALIDLLECFNGFTQACFMSVLDFLLPILDICVISATSIQSDLFLREVMNLFKATSGKMRLSEETDENTIIFYEILIRLFDRYRTVQMQKRNSVDFDDDNKSNYILSIIYILDELLNRLFFHGCPAQIDVMEKGMAAFLCGMEILFSEINELILNEFPRLSFFTLLKRLVSMEPRHFASISRWPSPLFNLLYSGLEFQYGLEDLRLVIPYDFLRNLSFNLWKIYPANFDNSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q646</accession>
    <name>A0A158Q646_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10581</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001226">
        <property type="protein sequence ID" value="VDN60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q646"/>
    <dbReference type="STRING" id="318479.A0A158Q646"/>
    <dbReference type="WBParaSite" id="DME_0000906001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000906001-mRNA-1"/>
        <property type="gene ID" value="DME_0000906001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045819">
        <property type="entry name" value="TTC7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19440">
        <property type="entry name" value="TTC7_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="785"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000906001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="833" mass="94254" checksum="F9B6B29FBABB05A3" modified="2016-06-08" version="1">MSSKLKGSRLESEVDRCRSECNWKRLMDLLPAIRSKNSGMENFADLIEGELILEFFVEKHGEPKSANLEELLCSEILLNKAVSSNDADYKKALKDVEKSRLDFAETPFVTLRALRLVAEAYAVKGFSLEASMCYMNKPSETQLRALFCFEKSAELTISYVQELEKSINASSRELLESTLERVPLLHLRRSLCDRPWDLEGIEWYRKIMTSLGDKIVGEKLQQRLSRQLAEVLIRGMPDSEYVNSQSVHSKSQSLRFYTGSNRSYFAPASRLEEILLLLFISEVLSTKDIVLSQMDEITGNRSHSLQNARSVQNLLTLVLSTLRQYELLANVYERSMKFANEDKYIWFQFALTLLCHGRWIRASRILNHCIGLGESDSNSLLQHMLVALTEIERIGDFSEAMKYSENAVRLSEETWLSGRCHLLYAISTSLKAETILHFKRRKEMHKKALSLFEKAISLDPYDDMAHYYCARQYAIVRDLNKAKEECERVLELNPENVFAIMLLALIFTAQNDLKAALELIVDALDEFPSYYTLLVLRIKLDSKCGRVDDALLTAREMFYFWKRPEIYDSTTVVSQTVKSSLRDMRGCTFHPMSSREAMVPLAPMVTAPLGILPPSPLTSSATVTSSVTDLNDGPLGGISNNSECCAAPSSISDGLSGSNAAASLFSRFQLQANIWLELVELFLENGRTDDIKSCVEEAYLIFPNSYQVLYLKGRLLAVRAKHCSESLVCERLRIDAKTSFLGALAIAPSHIPSLRHLADIYRSEGNIRMAEKMLKDIISLEPLNRDVWHLLGIVLAEGKQHEEAIECFKIASSLDESTPVVPFTCLPVLIRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6F2</accession>
    <name>A0A158Q6F2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3489</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000139">
        <property type="protein sequence ID" value="VDN53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6F2"/>
    <dbReference type="STRING" id="318479.A0A158Q6F2"/>
    <dbReference type="WBParaSite" id="DME_0000993201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000993201-mRNA-1"/>
        <property type="gene ID" value="DME_0000993201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF133">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000993201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="46924" checksum="BD4EF627A286B0FA" modified="2016-06-08" version="1">MRTTEGLVDAEGVARLWGQRKGKPQMNYDKLSRALRYYYDKNIIKKVIGQKFVYRFVGCPEGTSENFKLALSQLLNEKSSDSSSNNTRFTTNMNSKIASTNNSFPTPNNASQLLYTAPTTSISSPNSVCSTNSVQSISGINLQDDIKKSASINRNNIKRKKSESPRIIHATNVSSVEVTSTDSISDHAISQIKREQTTIASCLTTSSSSSSSPPPPPPPSSSSSSSSSSSSTSSLNNTPKIFSSINEQQQQSSIASTSTNSLLLSNNNESTALKAITSKPSSSSLKRSKPSPLDLSLNNPISPENNLIMHSPAAYFTNNTAAAAAVAAAAASALPYPSSPFCNVNFYPQFTNLSPFMIALSPFNTINNSPLHAQKTMFQFPPHPQSMANVAKAVSMMSVPPVLGATINLNNNPYGRTFVSRSPESLKTPVVPFPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PLF5</accession>
    <name>A0A3P7PLF5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PLF5"/>
    <dbReference type="STRING" id="318479.A0A3P7PLF5"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="1">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Activating signal cointegrator 1 third" evidence="2">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="374" mass="43192" checksum="7271D9DEC8B0E363" modified="2019-02-13" version="1">MIRNCMSCGRVVCEQEGSGPCWFCGELVCTRDERKVLEDGSKNSLILRSKFDRAIFSSASGSSDATIQNDLEAAKDLRNRLLEADADVDRRTRVHDLQSDYHNLENNIYLTKEEREAIIARKQEIKEFRARQKKLVALTLERENIKFQETHMNDADDPVIQSIMERSMNRVKQITDQNNPTFMSPNSFIAKYDETIGRKIKNIDYENIYDLEDSNFYLLNDQMMYAYVERKGFAIALYQPVASFLVHGKRKHIPWHDEVHLRGPLIIVSNTQKMTDEIFDHEISMCKAQTENFESDFPCGAILGRAFLDEVLSPAEYADVYPGDECCEVKNGFILIFKFFEPLLIPIPHIPSRSDIYKINNHLKNAVQDILLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PTR1</accession>
    <name>A0A3P7PTR1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PTR1"/>
    <dbReference type="STRING" id="318479.A0A3P7PTR1"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="171" mass="20365" checksum="BE644EDA7199AB8B" modified="2019-02-13" version="1">MIFVTVTKQPFHLSSLTVLVLFIIKKDLQIFKIFPSYCNDCQCMYTDVNHKTSTAHLIETKKLINHPGYQIPEWNKGYQLLRKTGWNEYEGLGKDGSGHRYPIRSVLKRDRFGFGLKKQTPKVTHFLPFDKRAIEKVKKKSKRELKEIERRKANRTKQLEIDFRMMFHFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PWK5</accession>
    <name>A0A3P7PWK5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PWK5"/>
    <dbReference type="STRING" id="318479.A0A3P7PWK5"/>
    <dbReference type="OrthoDB" id="262535at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13367" checksum="D2840981ADAC3D0E" modified="2019-02-13" version="1">MPYPIYTQICELLLILLFGPVEALRLFWGRKGNLTETPAFIAFSLLLSAADIALCIYWAMFQSYVLLIEFIVVCIQGGLVTIEILLAIITITRFSTYSFFLISLHHFKHFNKQFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYM1</accession>
    <name>A0A3P7PYM1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYM1"/>
    <dbReference type="STRING" id="318479.A0A3P7PYM1"/>
    <dbReference type="OrthoDB" id="10025033at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="134"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="351"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="954" mass="108891" checksum="08260BE0B825B8BA" modified="2019-02-13" version="1">MPQFPKKLKILAGRDKNTLESKHDKPHIQEHYYETGSESGTESEGNEKLKRKIPEGNEKILHDDFENIEEPGQSEGNKKEIINEKIEASKNYLQKSGAFTKEVMQRKYVPVERSAEVSAKRAKLPIFAEEQFIVETINDNVSIIICGETGSGKTTQLPQFLYEAGYTSNNQMIGITEPRRVAAISMANRVGFEMNLPKAVSYQIRYEGTRSPDTQILFMTDGVLMKEIQKDIMLSAYSVIIIDEAHERSMYSDVLIGLLSRIAPHRTKIGLPFKLIIMSATLHLEHFTQKSLFPLISPPVIHIDSRQYAVTVHFERRTPNDYLNASFRKICKIHENLPMGTILVFLSGRLEVSSCLLSLYALQFITSRNETDERNVELNEFGIADTVDLACEMDLEMVDDIINKPPPKDIPPLFCLPLFSLLSSEKQKRIFEPSPEGCRMCIIATNVAETSITIPAVRYIVDSGREKRRIYDPVTGVSQFIVHWISQASAEQRAGRAGRVQAGHAYRLYSSALFADMEKFSPPEILNKPVDQLVLHMKSMNIVKIANFPFPTRPDQDALEESEKRLILLGALEKEARITPLGRTLSMFPLAPKYAKILVMANQNGLLPYACLLVAILSVREPLISVYSLRGETNDETQSKMYDALKQRRDWCGQGQSRRFGDLSVMLKHSEEVCQRRGVRFKALTEIIKLYQQLMNLISSSCVVTDSLAVDFALNSPSDEQFRMLRQIVIASLTDNIVRRIDRSTTTEEIPKGAYESQRLKEYLFIDPSSVLFKEEPEWILYQEIIEINGKKCMQNVITVEPDWLARLALTYCDFVEIKNADPKYDPASDSILITQNAFFGSRRWSLGVVNRPIPRDINLYRQFARFFLDGSVCPKLAEYSTKLLSSPMAMVRPWAKLQARTENLLNALIEYEVSDRKSLIEMWKSKHEYLLDEFLEWIPRSLHDAIQLLWPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QA18</accession>
    <name>A0A3P7QA18_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QA18"/>
    <dbReference type="STRING" id="318479.A0A3P7QA18"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33610" checksum="AC794897EA7DCCA2" modified="2019-02-13" version="1">MTFFFKDTGSKGPTNDLDCRVIVNKVLTKSSLSPSCSSASDYFKENESFQANFFILLSSVAVVISEEEVRVLYLPAYNQLFSHKPEIPFVKATSSHVSGYPILFLLNAAGQVVVLSLPTLKSLLCCPLFKQSIELDDPVCQKISLSNHGLGMYLVYSSEIQKFTISAELAAELQECIGELFIPMDLPEPQKNSFFKGVSTLFVSQKESVDLDSIFADKSTGVPSNSGMRSVGRTILGPSANMEQVTSRNVTAGQAANLALQTLHERGEKLGATVDATERLKDTAVSLSQKTGKLVEKYEKKKWYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QF51</accession>
    <name>A0A3P7QF51_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AF4/FMR2 C-terminal homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000155">
        <property type="protein sequence ID" value="VDN53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QF51"/>
    <dbReference type="STRING" id="318479.A0A3P7QF51"/>
    <dbReference type="OrthoDB" id="5845605at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="2">
        <location>
            <begin position="480"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="733" mass="83137" checksum="2DA3341763C225B9" modified="2019-02-13" version="1">MANSFSSNSRDKKEIEGDWQKPCSSGVDNKQEISEDISITINDLFGEDRKRKRTSKESSRNSEEATKMQNKNKEWTKADGESPDSGVQVDETTDSDREQNQISTANLIKEITLISPLLSPPRQPSTHLPHLTYKDGLPSLTCILDLSPLEPMQRSLYMEKIRLNTVAPPRPPLSPPSRPSFNGHISSPKISDMNKSPKITKGFKINGSSLPKNNKDKSKSKPGIKRKDISDAKQKNMEISKRTESPPLIQKVIIKKEPVVRIITPITNYKDSEKNGKIINILKDIKDERSGSSVSNHKESEKDKGKELKLVNEQLSSATNEKSEQKDKLKAKDYCKAKEKDANKRDNDKQKQGNLPISKTVNDLSDSVVNSNSLKEKDGKRNEKLKESNQMRESSIADKSYNYNVIKEMKEKEKSRNKDEISKENRKDLSVTDKNDSLRKNRQNHESDSCCAQRTAPAMKFAFIKNEDGSFKSPTFYQSDVARPLKHQADKEANEDKVKRTILYLESVAYFILSIAVKNLKSYKDTSILSQQYNSLRETAELLKTSTNRFTQIANHPPAVLHFVSRVKLLSNRTQAVLNYHLFYLRSQQAIKNYGILANFEPRSLELEKAAIKGENISNGSQSSRSAATPSPASSTHSVGSERQKEITVPLNVYQTQRSQLKILHHLLWAYRIWSETDASMSKLEKDMVTHLDELCGRLMIESDLFILSEYLATGASWLSAEYEMEKLFLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SAR6</accession>
    <name>A0A3P7SAR6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SAR6"/>
    <dbReference type="STRING" id="318479.A0A3P7SAR6"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000238">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000251">
        <property type="entry name" value="Calmodulin-related protein 97A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="192" mass="22359" checksum="BDC3F37B38FB8272" modified="2019-02-13" version="1">MLTANPLNERKIQRQYTNSSNTTEQDEFTSEELQEFAQAFKMFDKDGNGTMNIKELGIAMRMLGLNPTEEELLNMINEYDVDGNGKIDFFEFCKMMKEMNKETDQELIRLAFKVFDKDGNGYITAQEFKHFMTTMGEKFSEEEVDEIIKEVDKDGDEQINYEEFVQMIAPIVHDDSKNDPFAESVKDFDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SJZ6</accession>
    <name>A0A3P7SJZ6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SJZ6"/>
    <dbReference type="STRING" id="318479.A0A3P7SJZ6"/>
    <dbReference type="OrthoDB" id="412308at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="296" mass="34058" checksum="7C63BAD38D19A1F4" modified="2019-02-13" version="1">MRNLINTTDDDLLILFTADTQYFFQCTIGNDACKLASKSIRFKNGLALYLYVLVSIFSQVIRKLILSMKSKPSALILNGDLTGYGHLHELETFKDQWLTIPIRILPGLGNHDYENNVNDCVGNHCANRMLYWLSLIPENNDLELDYHKKQEFFLKTTYLGSFAYKKFICSPSGANCAYVIQLHNRPSYVAQIEAPFTSWQITNSFQWLTNVLNSFNQSLPIFINLHNLDLISRIKIRDILDKLKDRKLRIFILHAHIHHYHRVDMKCTKAGSIPSIYVGSVPNNRKDSKVNNGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T014</accession>
    <name>A0A3P7T014_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T014"/>
    <dbReference type="STRING" id="318479.A0A3P7T014"/>
    <dbReference type="OrthoDB" id="5849517at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018104758" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="186"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="312" mass="35452" checksum="A111B5E718CEA32D" modified="2019-02-13" version="1">MALLAILNIQMVDAGCRASRISDSERAEILNLHNQYRTALATGLVSNKKARMPRGNNIRKLEWDCNLEATAQRWAENCVFEHSTKSFRNNAGENLYAYWSSSDIKRSGVCSSCFTIYFECQFDFINQPLIKLIFHGSGNFINKDIYESGKPCSKCARYPGSKCQNNLCVGAQIVGAGCQRSQISDSERAEILNSHNSYRSTLAAGRKKPGFNHPIFKILSRLINYILSFATAQRWAENCVFEHSTKSFRNNAGENLYAYWRSTTIDRRHMKAAATAWWDEVKLMFTTTNFSNYARTAGMIGHFTQVSFIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T1C4</accession>
    <name>A0A3P7T1C4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b/b6 N-terminal region profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T1C4"/>
    <dbReference type="STRING" id="318479.A0A3P7T1C4"/>
    <dbReference type="OrthoDB" id="5874235at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="2">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="114" mass="13397" checksum="EA9097CB40C20FC3" modified="2019-02-13" version="1">MAWLGLPVGFTDKFKQIARFLLSFFYSSDNSLAFDRVQYIMYDEVSGATLKFFFAVHFLLPWFIFVLVVFHLIMLHVTGRTSVLSGFGDYDKIGFFPYYWLKDSYNLVDFTCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0C8</accession>
    <name>A0A0N4U0C8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4361</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0C8"/>
    <dbReference type="STRING" id="318479.A0A0N4U0C8"/>
    <dbReference type="WBParaSite" id="DME_0000000101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000000101-mRNA-1"/>
        <property type="gene ID" value="DME_0000000101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846067at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="7">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000000101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="63087" checksum="E19C3137A6EFEC7F" modified="2015-12-09" version="1">MGLQLPDFTFNDRFRGSWSFLLLADEMEIDERNASSSTQQHNIDQMGVSKRKILYKNKGLTQQTLRRAREVECFQLRKAKRIETLSKKRNIELSVAEGADDNADPISWHGQQIIANLFSNDPSIQMAALRASVRWFNQGITEIEDWATLGLVDRIIFFTENNKPIEMRRAATKSLSGALTDVLQFLNIEEMHKLISTFIDYFSCQASRILIFIDRSDDFELRQLSVEIIGLIANEGMMQRDLCIELGAVPATVELLKRAESPLEVRYVTSLIPMLCNCGECCRDLIRMSSVLYVFQKQLLSVDDSILICTLEAVFCLSLGPNENIEVVVSSGIVSQVVYLLLSHLNQQVKFSALRVIGNIVTGSEHHTQGILITAVIDCGALHCVRNFLENGDLKIKKETCWMLSNILADSTNHVQEVISIGILPLLVKNLSSGDFKIRKEACHAVVNALIVGNIDQVLTVINEGAISALCDLLTVMEPRIVHLALTGIENALKKGEELKVTNGVNPFLRFVEEARGIEKLEFLQLSPNMEIYLLAHEIMETFYSEAYENDPLSWCDICQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0F1</accession>
    <name>A0A0N4U0F1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4387</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0F1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0F1"/>
    <dbReference type="WBParaSite" id="DME_0000002701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000002701-mRNA-1"/>
        <property type="gene ID" value="DME_0000002701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000002701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13846" checksum="359030D4396CF80C" modified="2015-12-09" version="1">MGVRFCHSASLFLHNYFFQMNGQLKKIFAGTFTTATCTISSCFLTIMHGADPVYPQATTFLTDSDESTKLWVMELRKLSAELIKDISVKGAFHYWQRLFTKIMHTSVDDSITVNRYNWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0S1</accession>
    <name>A0A0N4U0S1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myosin heavy chain A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS4521</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0S1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0S1"/>
    <dbReference type="WBParaSite" id="DME_0000016101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000016101-mRNA-1"/>
        <property type="gene ID" value="DME_0000016101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005863">
        <property type="term" value="C:striated muscle myosin thick filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="9 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="21">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="85"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="17">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1128"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1589"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1948"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1132"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1611"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN54548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="DME_0000016101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2000" mass="231107" checksum="B1741735ED4E31BC" modified="2016-06-08" version="2">MGELGKFEEDEGYVFLEVSREEKAQMSAKPFDSKKNCWVPDAEDGFVAAEIKSSTGDKITVVTVKGNEITLKKEEVQEMNPPKFTKTEDMANLTFLNEASVLNNLKERYFSMMIYTYSGLFCVVINPYKRLPIYTESIIKHYMGKRRNEMPPHLFAVSDEAYRNILQDRENQSMLITGESGAGKTENTKKVIAYFAIVGATQSKKEEGQKGGTLEEQIVKTNPVLEAFGNAKTVRNNNSSRFGKFIRTHFSRDGKLAGGDIEHYLLEKSRVVRQAPGERSYHIFYQLMSGFHPKIREELHLTNDLKYYHFSSQAELTIDGVDDKEEMGITQEAFDVMGFEDTETHDLYSSVAGIMHMGEMKFKQRPREEQAEPDGEEDAKNACFCFGVDHEEFLKALTKPRVRVGSEWVNKGQNLEQVHWAVAGLAKAIYARMFRWLINRCNITLDQKKTNRAYFIGVLDIAGFEIFDFNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKREGIQWTFIDFGLDLQACIELIEKPLGVISMLDEECIVPKATDMTYVQKLNDQHLGKHPNYQKPRPPKGKQSEAHFAIIHYAGTVRYNATNFLEKNKDPLNDSAVAVLKHCKGNQLLLDIWSDYQTQEEAAEAAKAGIEGGRKKGKSSSFMTVSMIYRESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALVLNQLTCNGVLEGIRICRKGFPNRMLYPDFKHRYAILAAEQAKNPDERAASIAISDFLCNSGHLNDEEFKLGSTKIFFKAGILARLEDLRDEALRVVVTNFQSRVRSYLAQTDVKRRIQQRTGLLILQRNVRSWCTLRNWEWFKLYGRVKPMLKAGKEMEEMEKLNNKIKELEETLVKEEGNKKELEKQIQGLIEEKNQLFESLEREKGRLAESEEQVSKLNAAKADLERQLQELSDRISEVEDRNADLGRQKKKNEQEINELKKKNQDLELALRKSETEKQAREQNIRTLQDEMANQDENYARINKEKKNQEEINRKLMEDLQAEEDKVNHMQKLKAKLEQQLDDLEENLERDKRTRQDLEKAKRKVEGELKVSIENIDEIMKQKHDLEQNLKKKEADLMHATSKLEEEQSLVSKLQKQIKDLESRIAELEEDLEQERQSRSKSDRSRGDLQRELEELSERLDEQGGATAAQIELNKKREAEMAKLKRDLEENNINHELQISALRKKHNDAVAELSDQLEQMQKLKAKIDKDKAQLLRDVEDANANADAEGRQKQEFEKQAKLAEMQYSELQTKADEQMRLINDLNALKSRLSNENSDLSRQVEDLENQLNSLHRLKAQLLSQLEEAKRTAEEESKERQSLAAQVKTLEHENDNLRLHADEEAEAKAECLRQMSKLNAEIQQWKARFESEGLAKLEEIEENKRKLNQKVQDLTDVNEAANAKIASLEKTRHKLMGDLDDAQVDVERTAAYAAALEKKQKNFDRIIEEWKKKCDDLAAELDAAQRDNRNMATELFKSKTIQDELLEQLESLRRENKSLSLEIKDLTEQLTEGGRSVHELQKMVRRLEVEKEELQKALDDAESALEAEEAKVMRAQVEVSQVRAEIEKRIQEKEEEFENTRKNHQRALESMQATLEAESKAKNEALRIKKKLEQDINNQKAQKKSKKSKFDSHPQELEIALDHANKANADAQKNIKRYQEQVRELQLQVEDEQRQKDDLAEQLASLQKRASILQAEKDELANQAEAAERARRTAEHDAIELREAVNDLTNQVNAINNARRKLEAELQAVHVELDDTITQLKTTDEMLKTATADAARLAEELRQEQEHSMHVDRMRRALEVQIKEMQVRLDEAEAAALRGGKKIIAKLEQRIRELEQEVDNGQRQMSDMEKDIKKGDRRIKELEFQCEEDRKNSERLTELVDKLQVKIKIYKRQVEEANSIDEVDMRFQKIFREHKRTSQNKGEEEVAAVNLGKYRQLQTQVDDANERADIAENSLAKLRSKNRASTMGPIGLSASASFVNFQSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0W5</accession>
    <name>A0A0N4U0W5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoporin GLE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4571</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0W5"/>
    <dbReference type="STRING" id="318479.A0A0N4U0W5"/>
    <dbReference type="WBParaSite" id="DME_0000021101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000021101-mRNA-1"/>
        <property type="gene ID" value="DME_0000021101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415359at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000021101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60749" checksum="F67D96FF13A1B92D" modified="2016-06-08" version="2">MDSKDRNLHHFSHRARYKSFSQEASLEVEIPLEESQPIDELAAHINAVNKIIPPFYDEFRSSLLNFVDEETRKYENNIGDKLIEEFLKNDDAKMNYGCIPLTRVVKPSSVSFNEQFQFIMRNSTHETIESVIAVEKTMAEKMSSLVRARDFELDRLKRDCEVAMHQTLANDNASSVRNDRQLHLSKLNEKIRQVSSNYSKQIADLAVNQREEYRILIKSLYEHDEIPPNISNIVPVTSAAVRKSTSAFANLNLARSQVNEQLNDSFTIYLGAQLKTMHNVRLLTCRLLSDMCRSQNSLNNKEFDSGRLYMNLSLYRRGLTGLILLVDREINYHIENKTDFARICEQSTELHFESLQVQLENISALASDLSKGKDRNTSTELIKACKGLQTGDVYVTKHSNLTSVQVIFHLVVDETIESDDMSSRHPCINGLRNVIRLCSKCGVTTFGIPLLLVEKANQKMTLAWCLKRAELVFKCVKGFMMEACAGCSTAGGGAPTAAIHYNVNFILPENLETCVYQQILEMFPTIFHLVPSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1H2</accession>
    <name>A0A0N4U1H2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1H2"/>
    <dbReference type="STRING" id="318479.A0A0N4U1H2"/>
    <dbReference type="WBParaSite" id="DME_0000045501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000045501-mRNA-1"/>
        <property type="gene ID" value="DME_0000045501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000045501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21548" checksum="4A7105461E474499" modified="2015-12-09" version="1">MRLFVHTFSILVNSADCDELANQMHQRWLSNKNFGRVAALIVLHYHKADDTNLTLFSKCLYHILTDYRNRFMIRNKNRLVFRNSVRALLELYTTFRQIDPIISESLLKPIFSSLKMLIDDQADNNDIESLCEIFIDKGSILVKLKPIKCEKIILRMRTCLCEWQQLTTNTRRLLLKNGKANGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1K7</accession>
    <name>A0A0N4U1K7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TAP-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4855</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1K7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1K7"/>
    <dbReference type="WBParaSite" id="DME_0000049501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000049501-mRNA-1"/>
        <property type="gene ID" value="DME_0000049501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015245">
        <property type="entry name" value="Tap_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09162">
        <property type="entry name" value="Tap-RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="8">
        <location>
            <begin position="274"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="9">
        <location>
            <begin position="493"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000049501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62463" checksum="DF82D7F351E27D2F" modified="2015-12-09" version="1">MQVYCDKFASRDGVVMNQIRIVHGASTGKEFFLRVLGEQVDGIKPILLETDQNDIVFFIDDDETALAIQAMSRRINDPSTSCPVTIISKKAPLGFNAVGQDEIDLLTWVLNDRYDAETRTLDLSYFSLDRAFHAKPSYFSLCQNNIMMAVIDLIDKYYGSVTSLIMKGNRLRFLDHFSCLKYRIRNIQTLDLSSNRIDSASELEKLKEWPVETLFFENNPLCSQFVSAEAYLRTVNLSRVETLCLTSVNKFLQISSLSLNKPKVYCISTQCKEFVENFVTRYINIFDSIDTNDRSFLTDAYDENATFSLSVENLSDAKGTHEGISDNNFRISEWEYYKGKVFCRGAMEIVVQLRKLPPTAHIFETFNVVDVPIVKGNIMRFSLQGFFRDASINMKNPLTDTSLSVLPRYFCREFVLIDKGYGKIAIINDTLFIAIGSSKRLEDYKGILRNMIEERRRNYAEEEVQSRMEANISPTPTLPELTPKELALAGYESMQKLLIELFSQQSQMKPEWSRKCLMDLNWDCEEAYKAFLALRDKIPSEAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U249</accession>
    <name>A0A0N4U249_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5084</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U249"/>
    <dbReference type="WBParaSite" id="DME_0000072401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000072401-mRNA-1"/>
        <property type="gene ID" value="DME_0000072401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000072401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8422" checksum="8AF10C1D152467AD" modified="2015-12-09" version="1">MINAGIVLYILSHISLSPDIVDDGEVTALQIAAACGFTTMMEILISFAANIEIPVAPHHSCRNGKLAAVEFLLENEAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2A4</accession>
    <name>A0A0N4U2A4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5155</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2A4"/>
    <dbReference type="STRING" id="318479.A0A0N4U2A4"/>
    <dbReference type="WBParaSite" id="DME_0000079501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000079501-mRNA-1"/>
        <property type="gene ID" value="DME_0000079501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5948587at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000079501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7604" checksum="32EAD41E59A9E9EC" modified="2016-06-08" version="2">MDEHYFRFANVGRSAHSKITSSTTKNAVSGCCHPTEYDPIKLIYMTQEHELKIKEVPGMIARRCTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2K2</accession>
    <name>A0A0N4U2K2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5272</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2K2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2K2"/>
    <dbReference type="WBParaSite" id="DME_0000091201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000091201-mRNA-1"/>
        <property type="gene ID" value="DME_0000091201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6572480at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000091201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29142" checksum="798F41ED9B6D5BB9" modified="2015-12-09" version="1">MIQIMSQNSSSSPTCSLSSIRSYSVDSSDELAMKLARRNKIIEGETVDAVVARHPSIYAEFSEFSRKQIKYFIETFKNLNSFQIASTKQFADFIRILQFMQPFIVRISFLNISRFDEDGDSFIDFNELKRMMEKLGEAQTHITLKQILKMVDEDEDGKICLREFLLIFRYSLTNRLMCSNVFNELALSVDVAKEGVQAAANFFQAKIEELSKLSKFEEEIRAEREEKRQAEFEKKERRQQFLANRAVFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U369</accession>
    <name>A0A0N4U369_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5522</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U369"/>
    <dbReference type="STRING" id="318479.A0A0N4U369"/>
    <dbReference type="WBParaSite" id="DME_0000116201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000116201-mRNA-1"/>
        <property type="gene ID" value="DME_0000116201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF47">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000116201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="48779" checksum="89E5AA18074672E1" modified="2015-12-09" version="1">MDCFADDRDALNDFAKYFNNSHLSDVSLLVGDEIYAAHRIILTKSSEVFERMLSQKWNGEKKELELVEEPQCQKVFSAFLRFLYCNHILLHPDNALPILVLADKYNVNNLRKVCIEYAVQNILPELSLRELFHVWFSYATKAYHQLLINSCIKILAWHFEEMITSEEWEKEWLSVDHEFRLWEAVQKWLMAPSHPERRGNTASPLLVSILPLIRFPFMTADELTQVERSPFVESHPKLFHPQILLAYKFQALPLASRANCKEFSGTQFILRNYTDVRWDRRITIHSEDLRLDCAYDRCIDQTFNITTRSSTFPLQAWNWKLKLTSQMVSNSHDELRMYLVSDDIDQPRSIEYLVSIVDDRKVIRSLAGKKNFTKTRYSADIEIEKKIDLNEIYTEKSPLLVNGDLHLQITLRPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U399</accession>
    <name>A0A0N4U399_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5558</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U399"/>
    <dbReference type="STRING" id="318479.A0A0N4U399"/>
    <dbReference type="WBParaSite" id="DME_0000119801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000119801-mRNA-1"/>
        <property type="gene ID" value="DME_0000119801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="60"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000119801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="30030" checksum="EE206AFE37762BAC" modified="2015-12-09" version="1">MQLYEISTTRKMILTNGRRTFCTDRYRYIERLRDEFLKRLKNSSLINRRRYLVYKNSTVGRDNAVLIPLVDNSEHFSILFTQRSFLLKNYGGQICFPGGKIERGELPLEAALRETKEEIGLDARTIKIYGTMPPIYNKKLQSRIYPVVGQLGNIENLRERELSYEVQTIFTVQIDELCEKFQYTYHRDGCFEYVLPKFNVSNFDIIRTNDQYPQKEFCIWGLTAVMLHSFLYYFVPFKYLKKITPPNYDNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3K0</accession>
    <name>A0A0N4U3K0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5667</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3K0"/>
    <dbReference type="STRING" id="318479.A0A0N4U3K0"/>
    <dbReference type="WBParaSite" id="DME_0000130701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000130701-mRNA-1"/>
        <property type="gene ID" value="DME_0000130701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000130701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11258" checksum="AA27886A2F212CEA" modified="2015-12-09" version="1">MRYVAAYMLAAIGGRHGVSKIDIENILGAVGIDCDNEQAAAVVQKMSGKTIDELIANGSRYLAVVSSITSSATSDIKGAPAVETNKEEKKEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U505</accession>
    <name>A0A0N4U505_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S15a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6262</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U505"/>
    <dbReference type="STRING" id="318479.A0A0N4U505"/>
    <dbReference type="WBParaSite" id="DME_0000190201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000190201-mRNA-1"/>
        <property type="gene ID" value="DME_0000190201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000190201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14768" checksum="EE9E28C378BCE01C" modified="2015-12-09" version="1">MVRMNVLADALRTINNAEKRGKRQVLIRPCSKVIVRFLTVMMKAGYIGEFEIVDDHRSGKIVVNLTGRINKCSVISPRFDISLRDLEKWTSNLLPSRQFGHLVLSTSGGIMDHEEARRKHLGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5F6</accession>
    <name>A0A0N4U5F6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6436</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5F6"/>
    <dbReference type="STRING" id="318479.A0A0N4U5F6"/>
    <dbReference type="WBParaSite" id="DME_0000207601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000207601-mRNA-1"/>
        <property type="gene ID" value="DME_0000207601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF29">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000207601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37397" checksum="5245F57DFC463DA6" modified="2016-06-08" version="2">LTFALNLWNLWLAVFSVVGSYFTGVELYNDIVHKGLVVKDLIVIADKFYQWKMSLIFSSKFDYERAKNWISNMESTAFNLSLLYIISIFSIKYTLQNRKALNLKWPLVLWNAFLAIFSVTGFVRITPVFIQQIKQQGVISTFTKIGPLFNDNVAGYWTFLWVLSKLPEFVDTIFIVLRKRPLIFMHWYHHALTSYFGFVAYASSDAFLIWIVWLNYFIHSLMYSYFMLQSLRLRLPPQVAQLLTASQIIQFLITHVVMIYLAFLVLTTDGKYDISVRGFLTGAFMEITYLILWIRFYYDSYINNGGRKYSIHMKADKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5F9</accession>
    <name>A0A0N4U5F9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6439</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5F9"/>
    <dbReference type="STRING" id="318479.A0A0N4U5F9"/>
    <dbReference type="WBParaSite" id="DME_0000207901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000207901-mRNA-1"/>
        <property type="gene ID" value="DME_0000207901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000207901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24335" checksum="9B9AFDFF7FCDFAE2" modified="2015-12-09" version="1">MSKVQRDVLVEAVNEVLKGSKVKKRKFRESVELQIALKNYDPQKDKRFSGSVRLKNIPRPKMKVCVLGDQQHCDEANANNIPCMNADDLKKLNKNKKLIKKLAKGYHAFLASEALIKQIPRILGPGLNKAGKFPSVVTHSEPLAAKVDEIRSTIKFQMKKVLCLSVAIGHVEMTTDELVSNVALSINFLVSLLKKNWQNVRSLHIKSTMGHPQRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5L7</accession>
    <name>A0A0N4U5L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6510</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5L7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5L7"/>
    <dbReference type="WBParaSite" id="DME_0000215001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000215001-mRNA-1"/>
        <property type="gene ID" value="DME_0000215001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000215001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27172" checksum="924745CF2AF3F485" modified="2015-12-09" version="1">MIWSAFVLRRIAIHQGGISARIFSLLSVFGGGIFLATCLLDLLADSIATLSKGLAVRTDFKFPIVELFIAIGFLFVLFTEQAFTANFSGHTSFHSGTMAHSTIGAIILVLALSLHAIFEGLSLGIISDIKEIYQIFGALLLHKMLIGFSLGIRLVQSPMKTITIIICFCIFAGQVVIGGFCGLEILNLLSGGSLYQATLISACAQALACGTFLYVTCFEILPHELNQPTVRLPKLACLLLGFLLITAVVLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5X1</accession>
    <name>A0A0N4U5X1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6638</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5X1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5X1"/>
    <dbReference type="WBParaSite" id="DME_0000227801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000227801-mRNA-1"/>
        <property type="gene ID" value="DME_0000227801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000227801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="73245" checksum="8C5AF34A8342551F" modified="2015-12-09" version="1">MPRESFFKKNGPLKVTVLGWDGENNRNQKANVHWADNSKCKIPKLEINGSEVIHFFDKAEPLNCDLESKDWIYMDSNRIIKITNDAISKYGEIICTMKAYRSPDVIKVKFDKGIEFRKEVQLNSSDFAKFICKTSSENGRVLPICYSFALIININKKADKILRILSLMTIAPQKERIGQLTKIKKPNDWSGLDVYFLGFDSVSHMTFRRKLPLTVKFLEENLNAVVLNGYNIVGDGTLHAFIPILTGKTEEELPLARKRFKRARFVDEVYPFDWFRYTSEFMLRYKALPRFLLAHQSRYSHNYLNLVELQDEHIVEHFIKLLQTNVLNNSIIVTMADHGHRFEKIRQTHQGQLEERLPFFSIAMPRWFRESDKGRTAWKNLQENKNRLTTPFDIHATLMDILHWPSEDELKRPGDLKKRSLSLFRPIPSSRTCAQAGIDPHWCTCLKWKSAMSPDQINISKMLADVALDTINLHTEPERKICAELHLVPNVSTIFLTTNLTELATIIIDNFSGMNPALIQKLERAKRLLPNKALLAYRKSFDTDGRRPDLTGNTEAKFAHYQLKFRTAPGNAFYEVTLLYDWNENSVTVDMKSISHINKYGDLPHCIIKKNYFMAMYCVCYDKINQTSYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6A1</accession>
    <name>A0A0N4U6A1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Testicular acid phosphatase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6797</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6A1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6A1"/>
    <dbReference type="WBParaSite" id="DME_0000243701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243701-mRNA-1"/>
        <property type="gene ID" value="DME_0000243701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF171">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38844" checksum="FC29210263071425" modified="2015-12-09" version="1">MLIFPTDDKDIRESFFVEPSEITNDGIMQEYLLGEELKELYGHFIGKYYQPSELRVITGVDNRTIVSALAVLASLLRPVGRQIWNENLPWQPIAIHTNEILDQVAFQFYNFSNEFCSPPSSFGVFDSCPNLREKLKQSEGYTTLLQRDANFKQWLSNMTGLTLSDLFFYQTVLDELIIRHNLKGLFLPEWANGDHYSEIFSKKKLRLHVDFIKLFIDDAGALLLDLFSSSIDDIIHNRTSNKSFLYSGHDSNLITFGMYLNLIQFTELPPYASYMAIEHHLAEGEDIIKGAKDVIIILLIILNVVLMFICSAFKRRINMVTDPEQSHLLRATSRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6L7</accession>
    <name>A0A0N4U6L7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maternal transcript 89Ba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS6935</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6L7"/>
    <dbReference type="STRING" id="318479.A0A0N4U6L7"/>
    <dbReference type="WBParaSite" id="DME_0000257501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000257501-mRNA-1"/>
        <property type="gene ID" value="DME_0000257501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024721">
        <property type="entry name" value="Snurportin-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11538">
        <property type="entry name" value="Snurportin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="123"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="13">
        <location>
            <begin position="289"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="14">
        <location>
            <begin position="430"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="15">
        <location>
            <begin position="602"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="16">
        <location>
            <begin position="773"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="17">
        <location>
            <begin position="929"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Snurportin-1 N-terminal" evidence="12">
        <location>
            <begin position="1049"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="18">
        <location>
            <begin position="1127"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN56962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1342" mass="156103" checksum="366F41D961936CE9" modified="2016-06-08" version="2">MKRKAEISTIQLEGDLNESRRLMNVMMDDFTSDFTLSPISRSKLQCFVEHLKSLILSKDTHIAESELSDNSWLLKKGICFPLSLPFGLKVSELKCHGKCRWKLPESVNVFGYWRMNTREDVFIDMNVVMSKEYFGSRDFLNFTYHIKRAYYVCGVAIILKQGEIDLDFTIEDHDQMKPMLIAYMKEGRKFEINNRALLSLFYMQIKFVKKNNINRKIGVRIHFSPPDSFAKPFRFRPTNNNLRPSFCFQNKKYDENSPTPFYNNGIIADLVRDRLEVHFENFFKKKAIFIKAVMLIQCWLQNRNFDKRSDGFGDFLLYAWFIYLYNEKVIGEHMAISDILITFFQSVVSVNWNDAQLGLAKDIDSSLYAQFGEYFDYTFLDVTGFYNLAANLSCSAFNCIKDAAKSAIVKLNSFKDFDLLFVKEMPFTNYFDIYIRISVPETYISSDLPSLFPLEYIDCCGNYSRIIVRYLTNLLLKAWNDRVDLFDFKQIFNLGIKWKVGEGWNRKIESLIVGARVIQGWNNIITRGPFAKSNDAVKFQDFWGKDICELRKFPDNTICETIKWCDSKFASSVLCRICSHVALRHMRLSGQLLVRSSIPNFNGGHSRSFTYITNAYNRLYQFLRQLQDLPLQITNIHPISPHLRKTLSFFELSYFSVFVQFYISVGLTMESSGKWGDNREAVALLKTAFYIALAQILNEQFSRAIPYQDYLIVVLDQVLFRLSILYQREVHLMQKDMNSGLITSDETYLKLQEREIIIKPRLSAYLYSVSQLYPAFAATCRLAHQWLSSHMLTDYINDIILETITAYIFVHPFTSVPPRSYYSGFLNFLILLSSHNWLMKPLIVNFNNELTEDEMNEMETTFIKMRPVLPSMVIFTPADSTGIRWTREEPQPLILKRIVCLASSSAILLQRNLDSIPVVIKSIFATDINVYDVIITLNNEHIVRKRNRCRRFVATKYLPVFDYDPVEKFLQSLRANFATVAFFFFDKSKDNQKSGSNTCVSSVTYFTMENEELLNGSMVYNEVFDVDGLIMKFSGDAIELSPQSVSSGHPRYTFYKNVARAEEVQRKRRAEFLERQKECVFIIFKHQNINTRNLFLDKADKADQEAMDVVEISSNKNKRNEKYADVLMLSEWLVDIPTNLSSEWIMVPCPVGKRLKGVTSAYNKKGNRFKQFRSYLPGSIRSKGSENATLLDCILSYETNTFYCLDVIVWNGIIQSDVTFDCRLFFINSRINENQNFGERSKENPFVFKSLPYCYCQINAMENLLKSNLDFTIDGILFYHSQVFYRSGQSPLVGWLKPWMLPEILNVTVPQRLMDGKETEIGASQKFIDNYNIEHNHISSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6N6</accession>
    <name>A0A0N4U6N6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Laminin EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6957</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6N6"/>
    <dbReference type="STRING" id="318479.A0A0N4U6N6"/>
    <dbReference type="WBParaSite" id="DME_0000259701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000259701-mRNA-1"/>
        <property type="gene ID" value="DME_0000259701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000083">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF67">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="13">
        <location>
            <begin position="217"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="424"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="532"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="585"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="632"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="679"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1441"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1616"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1851"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="2030"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="6"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000259701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2210" mass="244797" checksum="560DE8B1DAC9128E" modified="2015-12-09" version="1">MEALSCDCNPHGSTRFSCQEYGGQCSCRPNIIGRQCNRCAVGYYGFPNCIKCKCLDNQLCDERTGQCHCPPYVDGQSCDKCVSHAFGYDPLIGCQLCGCVPEGSEHAQLQCDPNSGQCLCKANIGGRKCDKCLSGYYGFPLCFECACDIRGTTEDICDPKTAQCKCKKNVIGDNCDTCRVGTFDLQTMNPDGCSECFCFGATDRCRSAYFPISFRNFDEEGWNVTDENGELSHADGTFRYTSSGNAPSSDVYFLVPLQDVDYTNSYGLKLTFVISSFPSNAVSKMNTAADVQLISSNMILEFWASEQPSDPKKPFPVEVKILPENFLTNKGERISRADLMLVLHGLKQLRIKACYYSDCQSATISDFQLEVARDDQNSFDNLFTATSIELCSCPPPYSGSSCQLCSPEHYRVSSGQYLGACIPCECNRHSGSCDVNTGVCFDCQHNTTGDHCELCIEGFYGDATTASPYSCLPCACPYSSVSNNFAVSCQVTETGLLQSCKCKTGYTSDRCDRCDVGFYGQPLQIDGSCKKCYCNENNNLSLHGSCNPISGICDLCENNTDGNHCEICKEWYYGDAIKAKNCSECSCNKCGSSTCDSISGQCYCYPYVEGSECDRCVENAWGFSSCQGCQPCHCSLASSSTQCHPDTGKCTCMPGATGPTCESCENGYWNYTAYGCKKCDCEADLSRGTVCDVRTGQCHCQEGATGPRCNQCLPEYLRIPVHGCKFCDECVHSLNNDDLFTLDSSLDLIATSIGNISTTVLTGARLRRIEAKIQETNIKLDNFSEADIRADIETLKEKMNSLKSPASAITIRLNRSMDMLHSVQLKLDKIVKDTEEISANSFDRIEIASWVVDHLKNLIRAIREGLDTADRQRWIGRAEDLLAQMKNISIDSSEGIEKITKLMKNQVDQLPIFAFASSVKELQKDLNELASNLDVMEKSTAAIDENISVFSVSQQAVDNLLEELNETMTKISARIEFNSRFKREVNKFDYEKKTELLEEEAARLSSMFGGTRIEAENGVRAANAYKEVVEMLQAAGNSSNDAENYAKEAKHLGEGQANAAKSSREKSASLLRSTSLIKSEMINEVSSSKIALSKQLSNVNQSINDQQSRVDSLRSKYDDQDIDGKTKQAITIASDAMSKVNKANELRAVQPQISSLIMDSEVFINRNVKSVDDINSARNQINQVIHNNISKLIQPTIVQLSNLQDLMLNKTNDIKLRQEKMDSLKEKISLARELANRIKLGVHMEKNSILELPLGMRIARSALHTNIDFSFRTFLLNGLLLFYGNEQSTAGTQTSDYIAIEIENGNIRTIVDLGAIPTIVESKTDVADGRWRKISVEQLGKSVSLHIYQPISHVVEEVRNATVSGPKFVLNLHPKRSRLFIGSIPPNVNVASDIQNRYFIGDIEQLTINGNAIGLWLSKEGTSRNVQGAEKQPMIATSTIDESLGFNGNGYIIQRMGQWNPSKKTEFSLRFRTFSPDGLLLYFGKERDFLALRINDGQVELSYDFGSGVGRVICQKKNYNDGNMHSVYVHRIGHEIKLHVDEDDLTEAKLPDDNFELELIDVFYIGGVPSDVSTRFAVIPFTGCIEGIRLEMNFIHLSDAKAIKEVQSSCSDKTIRLVSLISERSFVHFSNSTIAKNIEFMFQFKTKKPIAVLATIVSDEMENVLQVRLESGFVYVVLGGDTKDTLKVETDSLSDGRWHFISVAKTSKIKIYIDDLHSNEAYVPVDYDETFGQKNMLFFGKDPFSNLSFEGCIGDLVVNNHLLDFSEAETREVQLNSCYIVENDIISLPELKQSTSMSLKSENNVDSSFTTNFPVIHEATKEPFRTKSKVRSLNDCALRKAPYEQLEGLNGKRYGLTPTSRQEYHNVLASFDKKVTISMEVQATASNGVLLFVTNEQHTDHLSLFLVNGIVHFTYNSGTGQATLFSNRSIIDDEWHTIIIERDGAIGKLFIDDNLESVDNSSVGTDAVDIQPPIYIGGIPSDLRPIAAVLVPNVKAGFGGCIRELKLNDEAIGNEPKEFGIAPCNRTVESGLYFGQEGGYVVLNDNFKVITNIIEFDIRPRTNNGILLSVGSNECLAVQLLNGTVQFTIDNGAGKEKVIHLPGASNAVCDGHWHYMKLYKTKNLMTLTVDGKSSLHIMKKGKKTETTTNDPFYLGGIPKHAKQACLDIMENFIGCVRVYNIGKKPRKKKNINIDTLPAYGDVIRNQCPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7E6</accession>
    <name>A0A0N4U7E6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS135</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7E6"/>
    <dbReference type="WBParaSite" id="DME_0000290601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000290601-mRNA-1"/>
        <property type="gene ID" value="DME_0000290601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000290601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17851" checksum="F5451AB40507A2FC" modified="2015-12-09" version="1">MADHQFEQFEKCVYCKREIDNSSIFAIFQCGHLYHDACAMSFVNHVKVDVKCAADECAVKIHGRHPIRLFYTFDEEAFLENQKLKLSLKAAKDRYEKIRKQRNKLIIKSRHLKRKRSEKIFALFEKSREIEKMKDGSRGSGCLSKILVAQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7V6</accession>
    <name>A0A0N4U7V6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Xenotropic and polytropic retrovirus receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7248</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7V6"/>
    <dbReference type="STRING" id="318479.A0A0N4U7V6"/>
    <dbReference type="WBParaSite" id="DME_0000308901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000308901-mRNA-1"/>
        <property type="gene ID" value="DME_0000308901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14477">
        <property type="entry name" value="SPX_XPR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="75"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="531"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000308901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="932" mass="107498" checksum="DA07222BCA605FDA" modified="2016-06-08" version="2">MEITGLVIASGIGMSALAITVASVPFVTPAFRKICIPYIPATTTQLNNITKMLSKCQNISPVVDLGSGDGRVVNMKFGEQLASHLTPEWRKQYIQYEALKHLLGEVMCVAPTDDTDRDQFITQHDEEFFAECEKELTKINLFYSQKIAEAQGKYHELVSELTMLKENQSRESEPHRVTFTLRNRLVGKHSQMVNAAREHAKSAQQLRLAFSEFYLSLVLLQNFQQLNATGFRKILKKHDKIIMNERGLDWRINKVEKSSFFLNRDIETLITNVETAVINELEGGNRQAGMKRLKVPPLSEKQHATTTFSLGLFLGAFAVLAMAIILTWFGAKSRPNEPKWVAVRLFRGIFLLFICIWLCGLNMYGWAAAGVNHVLIFEVDPRNHLTYQSVMQISSFMCLLWALGVLGYLYAHLIYLPPFLFPLLLMIICTVIIFNPLKKPENIFRRDSRFWLIKHCFNVFTAPLHFVTFPDFWLGDQMNSLITSFLDLQYFVCFYATEVDYSNWTLTVRMVNVTINDHVPWGYVDVNTGRDMCTSASGVRALVSIIPATVRFMQCLRRFRDTGRAHPHLLNAGKYSTTYLVIIFKSLNNWAEKLDPTTTSIFFYLWIASYIISFTYTFLWDIFMDWGLIDPRAPKDSPFLREEMIYGSKWYYYAAIVQDFILRLSWVLNVSLGEAWTLESDFLTCITAPLEVFRRFIWNYFRLENEHVNNCGQFRAVRDISIKPIKKGDLESLISKMDSEDGVIHRGQDLRERVKRQKKAAKGKRQILRKARFTRIALTTSNNPTNIIAESKNFSTFQLPKIIVQCHTYLRYIMVLQCAKAGHHASGFELNIWLILYSRLKARQLGVANHAKFYRKDIFKADLTAYNTCIIFGTETLMEHCVEKLAEMNANSNLLTCRYPLPLNDHWQEICTIGSDVNTVWLYKRNGSKFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U800</accession>
    <name>A0A0N4U800_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7301</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U800"/>
    <dbReference type="STRING" id="318479.A0A0N4U800"/>
    <dbReference type="WBParaSite" id="DME_0000314201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000314201-mRNA-1"/>
        <property type="gene ID" value="DME_0000314201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF819">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12 15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033762191" description="Zinc metalloproteinase" evidence="12 15">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="64"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="312"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000314201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47890" checksum="7CE3ECDEE37947BB" modified="2015-12-09" version="1">MQLPVIRLVFLLQPIISCTASILANVSLPKLSGMDIMSSDKFLHIGIIERVSKTTLNLHRHRRQIIAGPQYEWRTYEIPFTIWGGDRNFRNLIRRGIRMWEESTCLRFREDTHASDAIRYVLERGDSCFTEYIGRNGGYQDIIIGSECAEEYVVAHETGHALGFWHTHQRPDRDRYITVNWKNVLEEATASFMPFHSMLQAFGIRQVISSRQAPYDYGSLMHYHAVAHAIKISDFTIVPKELKYVTTMGTEKMAFLDAKIINDIYCPNVCFGRTFVNCLSGGYPDPNNCNICRCPEGLGGVDCSQLQPSCTCGGELWATDRWQTLISPSGRNINCYWRISAPEGSRIRFKIIDGEFPCSYGCQSYIEIKHKLDVRLTGFRSCCYRPKEDTISDGNQVFVIFHPNGKIAKFTLQYAKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8I8</accession>
    <name>A0A0N4U8I8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Farnesyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS229</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8I8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8I8"/>
    <dbReference type="WBParaSite" id="DME_0000336301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000336301-mRNA-1"/>
        <property type="gene ID" value="DME_0000336301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000336301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31795" checksum="D120E33A251761FE" modified="2015-12-09" version="1">MIKEIIDALTNIKLDIIRKCVSNLTKDSSIYCSQRVDNLFNHVVFGGKYERSQLLISTYKALDRDASSKRILEVTKVAACLEICQAFLLTIDDIMDDSIKRRGKNCWHTLPSIGLNACNDAILLDCIVHDVLNDALVQDCENFLEILFTVNLIYIIELHFRYRDIVNNKTSYYSFYSPIKIACLLADQPLVPSQWKSLAFKSGYLFQAQDDYIDCFGESIITGKIGSDLREGKCTWIICKALDQTVSRPDIRRTLTVCCDYIFFIIILKLIAIIKIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8M9</accession>
    <name>A0A0N4U8M9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS278</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8M9"/>
    <dbReference type="WBParaSite" id="DME_0000341201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000341201-mRNA-1"/>
        <property type="gene ID" value="DME_0000341201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856121at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000341201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13398" checksum="9575D63DAE630DB7" modified="2015-12-09" version="1">MSKYRKNWLNNTGTYDKITSSIEPHSFGTSWNSIRWNKPLSNRPSCHFLSPIDRYTSKSYCSGKFGYSINERKSRLNLDDNPSSAYSNTNNYSLSTNSSRLKRLSYSTSEPSYLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9S2</accession>
    <name>A0A0N4U9S2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7857</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9S2"/>
    <dbReference type="STRING" id="318479.A0A0N4U9S2"/>
    <dbReference type="WBParaSite" id="DME_0000385201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000385201-mRNA-1"/>
        <property type="gene ID" value="DME_0000385201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF10">
        <property type="entry name" value="PI3K21B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="323"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000385201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="50548" checksum="8EE91A7725CD4C29" modified="2015-12-09" version="1">MIYGRGRALFSKLVKTRMDSPNGTFCVRRSSNGKDYTLSLKHEGKTRLIKIIISKDRCGFHEDALHYDSVISLIEYYKRNSLKEYNVHLAIQLLFPLKQQNAQKSFWEIDGLHSIEHLFCQLRGICAAHIRLMRFDEKICVELDSLREELSKKRQARAAYKVARDLFQGQIAILSKNGDLMTTESDLAYLRANLDLQKKRLETIENQLQQTNECVVIFEKDIQENENIHISLLPKYSKIHRELDRCRFRLCQQKIPEAILDKVQQEVSILADAEHPALSKVLVRCHLRWQPDRYLATDCTKYAGELKEKTINSRITLNTLNLWRLFEENAIKIIKKLMEHNPGNSDGIFLIRPSQSQDGQYALTLSYGDHIHNCLVEYRDIKHPESCGFAFLNTKLFFPTIVDFVRYYSNYSMKEHNTQLDTRLKMPAFRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9T2</accession>
    <name>A0A0N4U9T2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7869</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9T2"/>
    <dbReference type="WBParaSite" id="DME_0000386401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000386401-mRNA-1"/>
        <property type="gene ID" value="DME_0000386401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847395at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000386401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30606" checksum="19CD06AF6BAECD22" modified="2015-12-09" version="1">MWLPRLMRAANEEQEHRAAVLHSQYSTVGADILCECGHLTSAARTSAVSPLVCARSTSIVLKHRFALLKWCCIAFLMLSIALIAFSSLLNSSSPKLSSGSSYLFFFISLISLIVFVGPCCLKIRSMCHRRNGLRESGQQFYIPRLQYYPFRWPSLLLSPSIYAVHNHNDHHPTNSRLTSFLSRMDDPSARLPSYSDAVKEPVFAPPPYSFIMQEQSLGATVYESPESSNISGENSGENHSKNMNLESELFMEEISSPVEVSTSAAFVENEAERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9U8</accession>
    <name>A0A0N4U9U8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7889</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9U8"/>
    <dbReference type="STRING" id="318479.A0A0N4U9U8"/>
    <dbReference type="WBParaSite" id="DME_0000388401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000388401-mRNA-1"/>
        <property type="gene ID" value="DME_0000388401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="153"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000388401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="36495" checksum="EC17A0440F50185D" modified="2015-12-09" version="1">MVIIHGKGDFTTDEVRAYKQQIYQNVISAMRTLLDARQKLGFPWQNPERQKFVDSIMKFTSSELMRGIDQSTFGDIAPLIRDFWSDEAIKRTYEQRNLFQICESCVYFFEHISRVSMSDYYPTNKDILFCRKATRGITEHIFEIQRIAFRFIDVGGQRSQRQKWFQCFEDITSILFMVASSEYDQVILEDRRTNRIVESRSIFETIVNNKSFSNVSIILFMNKSDLLEEKVPKSDIRQYFADFRGDHRSISDVQFFIVDKFEACRRNKSRPFFYHFTTAVDTENIRRVFKDCRETILEQNLKSLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAG8</accession>
    <name>A0A0N4UAG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide PPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8027</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="VDN58054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="DME_0000414401-mRNA-1"/>
        <property type="gene ID" value="DME_0000414401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5833294at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
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        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000414401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18766" checksum="3A53D44F290C7C71" modified="2015-12-09" version="1">MASNQLKSLPINEFVEQTAMNKALNVAKQMDCDDYDFIIGCDTVVFHEGKIIGKPKDKADAEQTLLRLNNSTHEVYSGVAMINGEQECEVFHVRTLVKFCQIPAEVISRYVQSGEPMGRAGSYGIQGKGAIFIEKIDGCFYNVAGLPINEIAHRLWKREKKLPITTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAQ9</accession>
    <name>A0A0N4UAQ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8133</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAQ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAQ9"/>
    <dbReference type="WBParaSite" id="DME_0000425001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000425001-mRNA-1"/>
        <property type="gene ID" value="DME_0000425001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000425001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23919" checksum="527E27429E6E3ABF" modified="2015-12-09" version="1">MHLTRSVEILTKVNEELKNDINNLKVSSLGNFEHSKIETEQVLETIEEYFEKKEKEPCLVGINIPEKSKDDESATADRLLSENIVVAAGFKTEFIKEVCHHGRKGIGRPRVLKIRLEDKHMAMSVLRNKDVRSIVPPGSFLRKDLTKRELLLDKQLRKECYTRNQSLNLKKYVVRNLQIVELRQPRQWIAPTSNFLIPTYSHQSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB29</accession>
    <name>A0A0N4UB29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRELI/MSF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8271</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB29"/>
    <dbReference type="STRING" id="318479.A0A0N4UB29"/>
    <dbReference type="WBParaSite" id="DME_0000438801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000438801-mRNA-1"/>
        <property type="gene ID" value="DME_0000438801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000438801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22566" checksum="DE4017A2708FE046" modified="2015-12-09" version="1">MKIWSSEHVFDHPWNTVVTAAWKKYPNPMNGAVTGIDVIKQDIQKNGTLRSERILQSHFPIPTWATKLTGFSGMQYSHEVSIVDPASETMTLLTRNLNGAHFLQVDEKLVYTPDPLDRTKTILRQEAAITVILPAFTDYCEKAFLSIYQSNAEKGRKGIEWVIDQCTKEYSQLSNKVSLLGEGVQEISGNMFAAFNRSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB44</accession>
    <name>A0A0N4UB44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nefa_Nip30_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8287</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB44"/>
    <dbReference type="STRING" id="318479.A0A0N4UB44"/>
    <dbReference type="WBParaSite" id="DME_0000440401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000440401-mRNA-1"/>
        <property type="gene ID" value="DME_0000440401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000440401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27801" checksum="7AC68D5556E61EBE" modified="2015-12-09" version="1">MDDRFISEKNAEEVRKKRQEEWEKVRKANDPVVKSFLLSEVPEEDHRSLYERLKEVRDKKQAEYDEEHKFKNMIRGLDSEECEFLSSFENMKEKEDKKKKQEEAAVLSEFERARCRTIPDDKVPSVSRLRFKAVRDGPPRPNRQAELLKGAIKRKSITEDYENGSKKTLMSIRSQIIATRPTAMKVVGMLPGIANYASSSSNSDSDNDSDYSGDLPVLPALIPTTPDKNEKQKSATVEVETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB72</accession>
    <name>A0A0N4UB72_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8318</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB72"/>
    <dbReference type="STRING" id="318479.A0A0N4UB72"/>
    <dbReference type="WBParaSite" id="DME_0000443501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000443501-mRNA-1"/>
        <property type="gene ID" value="DME_0000443501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09414">
        <property type="entry name" value="LIM1_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09830">
        <property type="entry name" value="PET_LIMPETin_LIM-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000443501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27060" checksum="72D04619B28C0FCD" modified="2015-12-09" version="1">MRKVCVHCKCERTDHDVGQSRSLSVYERLGIEPPASMAKLSGSIGRSNDAPGSVGHGYSWVPPGLSRRKIEEYMAQLPNNVVPRINSIGEKYREKQLMIQLPRQDLSVAYCKHLLNSVERKVFEEFINARNEIALDIGFVCPNIHMQMECRKCSGILEKNEMAVMAPKLGDQCGWHPACFTCNTCEQLLIDLTYCVKDGLLYCERHYAELHKPRCNSCDEVDFFKLFTLLYYFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBG6</accession>
    <name>A0A0N4UBG6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Presenilin</fullName>
            <ecNumber evidence="5">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8427</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBG6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBG6"/>
    <dbReference type="WBParaSite" id="DME_0000454401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000454401-mRNA-1"/>
        <property type="gene ID" value="DME_0000454401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000454401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28377" checksum="49116C731915125D" modified="2015-12-09" version="1">MRLVDAFRIFSHFSESDDENDEKELKYGAQHVIHLFVPVSICMAFVILTMNTVGYYSRKDGQYLIYTPFTKETDSAGERLIMSFGNAFVVLGVVVIMTIVLILLYKFRWYKVIQGWLTLSSLILLSLFTSMYLQELFKSWNISVDYITIFFIVWNYGVMGMICIHWKGPLRLQQGYLIMMSALMALTFIKYLPEWTVWTVLAVISLWDLVAVLCPKGPLRILVETAQERNEPIFPALIYSCEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBI5</accession>
    <name>A0A0N4UBI5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8448</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBI5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBI5"/>
    <dbReference type="WBParaSite" id="DME_0000456501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000456501-mRNA-1"/>
        <property type="gene ID" value="DME_0000456501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF193">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="758"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="852"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000456501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116886" checksum="C13A6A93EFA538BC" modified="2015-12-09" version="1">MRAHERMNSLSSNLSATTNDEKINSMSRKRQKLLESVLTNDMALVMRLLVDNRIVNGNCNRIASFLHYASYFGYYDMASYLIDEGARLDAYDKWKLTPLHRACLNNQAQIVDLLLSFGARVTALNGLLLTPLHIAAAVNALKCGQVIVNYDQDSIDWTDQNGCTPLHYAAYRGHTNFVSMLLERGANIEARNNAGLTAIAWATLAGKIEVMNILRGFKADFNCRDSDGKCLLHYAAVSGNMPVTTMILENSTLPLNSKSSMGYTPLFYAVLNDHHDLFTTVFKLLISTKSFNVSETFGDNHLTLLHISAGLTDGTKCCQAIVESISFLDDITTDGYTALHLACIFGRIMRAKLLIDRGANVNAKTNSGFTPLHIAIQNCLDIVVKHLIEANADVNIYLFRMTQSGYNGMHIAAFYGMIEIVRILDKNGLSAMQKSKNGLNALHLASQSYMQKCCFVVDYLLSIGTPTCELDDSGNTALHYAANAGSVTIVHSLLRAGANINILNKLQQNALHIVSQNSGDNFFECAKLLVDSDDTCVVVRDIRGFLPVHYAVYNNNIELTRILINKQPSANVLSSLEPHHLTLYHIAAGSKNAQLLQKLLVHYQSLIADSNSDEKVGLERDAKGRIPLHYAMHSGNINCVQVLLQVVGHKALLIKDIEGLTPLHAAAAKGHYKCISIANSVLSKQEMQSYDNLHRTPQMIAVSNGHYEFAFAESNGFTEDFSHLDKNSRGIIHRAAFQLDSFLTTINDDKFSNVPDCNGVTPLHIAAAVGNSKVVGHLLSLHAKETKNNQGLTPVDWAAGRNQCTTLRLLLRSLPRQNRFNALLLAIEQGHLDCCKILLQYDPNYLLCVGRLNRTPLHFAVYYGHLKIIEYLLQRNISLSAVDSSGLTPLMTAAISCHVNAPRIIDILMEAGSSFSGTDISGNNVYHLACMANTPDNMLHLLKYTPQLVDGQHEGHLINSVNCKKETPLHLACNAGWLSVVVKLMSLSTCAINMKDEKGRSPLQEVDGDSKAIDINQVLIRVIRVLTLHHRVWSFIKVLFGLLLYELPLIFIIGVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCH2</accession>
    <name>A0A0N4UCH2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8766</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCH2"/>
    <dbReference type="STRING" id="318479.A0A0N4UCH2"/>
    <dbReference type="WBParaSite" id="DME_0000496701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000496701-mRNA-1"/>
        <property type="gene ID" value="DME_0000496701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12760:FF:000004">
        <property type="entry name" value="FtsJ-like methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000496701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="876" mass="100728" checksum="42040858A4873DEF" modified="2016-06-08" version="2">MENLVKKRRKAIWEDYNQELDEIPKIRRLEKVPSDEDDTKQESTTYEINPTSIISTVNSENKGAAILAKMGYGGGGLGKSEQGRVDLIPLSTQRGRIGLGHKATTDIGRDFEAKWDDSLEIKDVTETVLWISADEDVRVDVRHSLCEEWIIVGDRKERIDNETQYCSQNLLTKMLEAKNVFDHLSDKELREARSRANPYETIGSVFFQNRAAMKMANMDRVYNWLLSKEDATSLEKKNPIKNIDIKNIHSSRAKTGQNIDRESKIFYFADVCAGPGGFTEYMLWRKGFYNAKGFGFTLKGPDDFKFERFGASSPAYFEPYYGPHNDGDVTRPDNIAAFAELVKKATNGGVDFMMADGGFGVEGQENIQEILSKRLYLCQFLVGLSILRTAEEGNVGGVFLCKLFDIFTPFSIGLIYLMYIAFKRISIHKPHTSRPANSERYIVCDGLIEDGRALIRDHMTSVNNTLQKLVDSNEKLLDVNEVVPADIIQSDRDFMHFIVNHNESFVKRQTLYLNKYRVFAKNSGEIDISQGKLREECLNYWLIPDIPKRRPNNKFESLSAAAARLFKKVVDFEDLSRPPSVFCDSEISNHNENRMRFAELRMCALTEKEQPFLLISIKMGIFCRYPNSISDFEKLNFDIQMPCDTVLFVQRTTVYERLGERDLEEGRPALRILDAAVIDGDDISDLPYDQRMQAAQKLCDVIRLAHDPPGRRPARAFAARLFKLDKLCHELEKFHIVRSRGEEIAVVEDQPGAFFYCRGMRVVSILIEPWILCWSKSKHRIYAFDKSGNNRPVFCEQFTESQCCVGFWKSIITKKSQPQRPIENYQWRWEWTNLLQGGQSYGCRQILENENHPSLPTWRSIHNIARDQKRKITGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCR1</accession>
    <name>A0A0N4UCR1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8864</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCR1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCR1"/>
    <dbReference type="WBParaSite" id="DME_0000506501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000506501-mRNA-1"/>
        <property type="gene ID" value="DME_0000506501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000506501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48627" checksum="AB065E129A82BE39" modified="2015-12-09" version="1">MVPININSRRFALIDSDLPSTDRKPTPSCSPEIQNSPFVFQNIGQPKQSRIDGEVWPPIFKPEFIRSAKMMQPRKGDVFVCTYPKCGTTWIQHICSQLMTDNYGPQVGHGKELCVTSPMIERMGAKFADNLDSPRLLKTHFSWYNLPKSTQAKYIFVVRNPKDCLISYFHHNRNFKIYDYEHGNFSDFFELFLSDDIAFGNYFNHLKSWLPHITDENVLFLKYEEMCEDLPEAIVRIGHFIGGKAAKKIEDPTILEQIVLESTIDSMKKNQWRWFPADNLRQNNFVRKGGSRNWKNHMTREQSDRIDAEFRRQFEGTLAANWWRKEMAWELDGQESEFLLNDDDFYSQRSNNLPTNDDDVEDEGIFDINSSIKPTEPSKAITIPVPAWRKYSTAYSLSSGFGSLFSAHSSLSSSPFDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCV1</accession>
    <name>A0A0N4UCV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8914</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCV1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCV1"/>
    <dbReference type="WBParaSite" id="DME_0000511501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000511501-mRNA-1"/>
        <property type="gene ID" value="DME_0000511501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000511501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="85498" checksum="36237AD5EE7FAD37" modified="2015-12-09" version="1">MDLSDLTNIRQSSKINVSYRGCEEIREICESKINSFFERNIVLWKRVGRPCSFPLDVKVSLRFEPFNQSVLFDNSKINSIKWESVAFLHLFFINPTMVEDYKNTWRHEVSEWFATVNAIESSEWIIVFDSTKAREKKTRGAILERMKSDFSKFINRIAEIYDGSTSSMNALQNLVQFSLFSALDNFATNRENMLADYKENFNQPNFNFIRHCGLQMDLSHLYYSLGINEQSLALFDELDALLSLIVSHYSTNDSLPQWLQETHSFNNACPLLLPMLYYNEPNASMSLIEFRCLILANQILNSLRVYQDRIQQINLNDMPNLEQIKLDFAAILLRYSHHCLSTIYENISSLKLKFNHGQVQCWIIAFCIEANQLTSLLMDASLVQRATYSACSLSVLKCSAIAELGKNTKDHCFREFGEWFENGAKLCGSLANQSNAVVEIRHIVADRQQFTHYMQKYHESSIALLKHFNWKRQAKFLSWQLANFLLSSDRIEGALPYLLKFVHSLINEGCSQFLLINTLRTLVIQLENFPDLYLKELVEFYLMLSLNCKDEKEKLEYCGKLLRLLDSNQSKIRLSPKQSHLLSPFLVHLQKSASKCGLSRSPNISIRDYISHVVGTPGMQLEQKFEIENKFPSQISDYCMRVIFKKMPSSQIFSKRVGGRFPHFECSYNRLDNTSRFGCVWKGECNVPIMKDSTNGMNLSGVIEDDIQDLLIFESSKKGENSVLEPGLSTLSLYAMVGFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD40</accession>
    <name>A0A0N4UD40_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCDC66 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9020</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD40"/>
    <dbReference type="STRING" id="318479.A0A0N4UD40"/>
    <dbReference type="WBParaSite" id="DME_0000522101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000522101-mRNA-1"/>
        <property type="gene ID" value="DME_0000522101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919113at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000522101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68909" checksum="585C5EA4B2962C2B" modified="2015-12-09" version="1">MNPSDYNENNSNLSRQRDGSLIRKKRLQWAIEKANEETWFPFGTPGGGAPNKKHEAIDHQHLKELQNCGTAESVCEYSSCHSQQSSVSIDKPVNMANPVKVVEAGPQNSSFINPCLSPYVPSVNGPIPVRFIYPQNSFGQAMQPEAFQLSPNGFSGYSLAYPVQIISQSFNDLSQTKTAVDGQQLEVIQPCSEQWANQALWRNYPPIESVRTSTPTSFGINNASSGNQPLAVVRPLIIPIVPPNHYMDQQSTLLSQPVPSEKNNSLSSSTTSLCSSYLRSIDSDSKIRAKQTEQIFDAQVSEKKKAEALRIEEEKKELIKKENERKHMEEIEAEKINEEEMRRLKAEEEKARIEAAILDSIEKAKKEAALLRKAKIYKHILEGSENTLEKSVLGDDELENSRLIREVEVLERQKQYDMERLMNGLKIKSKDSKNDNRQNPMPKGSRNINCSSTSADDSLPFDMNLSRNSRGRQSLRLPSKPKHLLQHRSDSTERISLKNDIKKRRVPPEQNSSRKSINGSTISENNQFVESPVSNKSLVNDQCFDENIPNGVISSSKNSFDRLHKPSPELRRSNANTLDHRLSIGLPSNIMKTRNETVNRSKITINGNSTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDB7</accession>
    <name>A0A0N4UDB7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9113</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDB7"/>
    <dbReference type="WBParaSite" id="DME_0000531401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000531401-mRNA-1"/>
        <property type="gene ID" value="DME_0000531401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000531401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18642" checksum="E816B096E916EDE2" modified="2015-12-09" version="1">MVLIAQLGLHYNKNDEKLEIYMRSFINVPPTVARHGAKCVARIYVIKNVRKSWLSRRSPTITIDENSPDKYICFKTLPVLRRTTTVFNEFFSCEVKRNLFHVCVIKIQFCNFDRTFQIIIIIIIIELEISLRYLPSSERLTVILIGATNLRLLGETNSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDV3</accession>
    <name>A0A0N4UDV3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9269</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDV3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDV3"/>
    <dbReference type="WBParaSite" id="DME_0000552801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000552801-mRNA-1"/>
        <property type="gene ID" value="DME_0000552801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046349">
        <property type="term" value="P:amino sugar biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="350"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="521"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000552801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="673" mass="75735" checksum="08FED23E2FCEE62D" modified="2015-12-09" version="1">MCGIFGYLNFLVPKKRNEVIEILLQGLKRMEYRGYDSAGIAIDGSNDIEKPHSKIALIKKVGKVSVLADYIKESDECKELDFEMEYIIHCGLAHTRWATHGSPKDINSHPQRSNSNNEFLVVHNGIITNYREVKEYLLKKGYEFESETDTEIIAKLIQHIADKNVEFSFRQLVEVTVQHLVGAFALAFKSIRYPGQIVATRRGSPLLVGIKSSSPITTDHFPVFFSKEERKCSTTSIRPFNPNDSGVEYFFASDASAIIEHTKQVIFLEDDDVAFVENGSLSIHRICRTNNSPEFRAIQNLTLELQQIMMGEFKTFMQKEIFEQSESAVNTMRGRILADGRVQLGGIKDYLADIKRCRRLILIACGTSYNSAIACRQIMEEFTELPVILELASDFLDRETPIFRDDVCFFISQSGETADTLNALRYCKPRGALLIGVTNTVGSSICRETHCGIHINAGPEIGVASTKAYTSQILSLIMFALSMSEDRISMQARRAEIIRELRSLPDLIRETLKLDKEVLNIAKTLQKENSLLIMGRGFNFATCLEGALKIKELTYMHCEGIMSGELKHGPLAMVDRNRRIVMIICSDNVYKKSLNALQQVIARDGDPIIIADSEVPKNDLANRSHILRVPKTVDCIQNILTVIPLQLLSYHIAELNGLNVDRPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE77</accession>
    <name>A0A0N4UE77_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS711</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE77"/>
    <dbReference type="STRING" id="318479.A0A0N4UE77"/>
    <dbReference type="WBParaSite" id="DME_0000566601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000566601-mRNA-1"/>
        <property type="gene ID" value="DME_0000566601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000001">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="365"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000566601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="669" mass="78675" checksum="244370F7AB518295" modified="2015-12-09" version="1">MEEWPILEESILAIQNQKPNKTSLEELYQIVENIAVADSSLDIYDNVKSFVSNYVKSKREILLTESDAASSFLERLNFIWLQHCQQMELKKYLLNLLRQDLGLDIFRNVIMENQNIRTRCTKEMLKLISMERGNARIDRQLIKSLIRMLSYLAIYQSVRLFFGKYIQISLIKYLFKSLLNIFVFENAFLQTTKEFYELESKKLIDDLEVPEYLQYVKRRLDEETVRVDYYLDYSTQRPLLTTVDTCLIANHMESFVEKVNLLGFDTMVLENRFDELSLMHSLLSRTKSGLDILKKAFVDHIKNEGRKLVISEDSEKTFVDDLLVFKRKLDLIIDRYNILSCFDKNRKFVEAEKDAFDFVNLRLNKPAELVAKFMDSKLRAGNKVATEEELEVLMDEVIVIFRFIQGKDVFESYYKKDLAKRLLFGRSASVDAEKSVLSKLKHECGSGFTKKLEGMFKDMEVSRDIASNFKQYMEHEDRKGLLDSDVEYSVNVLTTNFWPHYDPMEVNLPQELSKLQEMFKQFYTSKYSGRTLQWQYSLSQLLLRAYFSPTVTKELQVSMFQALVLFLFNKKIEWSYEEILNATNIESNELCRTLQSLACGKLRVIKKNPRGKDVNPDDIFTFNSECNDKLYRIRICQIQMKETVSDFSTISSLFFFLICSFFSNHSHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEK9</accession>
    <name>A0A0N4UEK9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS813</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEK9"/>
    <dbReference type="STRING" id="318479.A0A0N4UEK9"/>
    <dbReference type="WBParaSite" id="DME_0000581901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000581901-mRNA-1"/>
        <property type="gene ID" value="DME_0000581901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000581901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41622" checksum="355F6D1750643AD5" modified="2015-12-09" version="1">MEPSNTEVTMPIESSSTMPVPISNSFQTEIKVEHVKHTWTVKNFSYCYQEYLENFIHLHRGEDTLTWSIKIYPKGNGENNKDFVFLCLNRVVNSANASCKSGKIGFTSRFILRTSEMKEIEMRIHPNPSHSDYVSYIKRDVLFPQIHPSDSIIVNVEIDVAVETITTIVEDLLTVANCEQQLMDDYLKMLKESVLTDFLIKIGDHEIRTHRAILAARSPVFFAMLKHEDTNEVKTGMVVIEDIEYETFLELLNFIYCGRCSKDVTEFSFASDLLIAADKYRLDELKNYCEKALIQAITFDNVCDLLIISDIYNAPRLRKRTLSYIIQHPKEITSTSSWAALIKDHHALVTDIVRHFDKSGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFH3</accession>
    <name>A0A0N4UFH3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1082</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFH3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFH3"/>
    <dbReference type="WBParaSite" id="DME_0000618501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000618501-mRNA-1"/>
        <property type="gene ID" value="DME_0000618501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="131"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000618501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25585" checksum="412A968F69A02F03" modified="2015-12-09" version="1">MATTSSTIKGYNAERYYIATQGPMSITDEKQSNNHDCTIEDFWTMIWQQNVNCVVMLTECIGELEKCDQYWPKEIDKTCQYGNILIRLVDILDKCTYIQRKMEIVVIGQKRSIYHLQFKNWRDFRAPQNTEHLIKFIQDIHQLKPSLPIVVHCSAGVGRTGVLIALDILLQKLKYEGDIDIFKCIRTLREQRFRMVQSFEQYLSLYQAIAFTIQTDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFN7</accession>
    <name>A0A0N4UFN7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1160</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFN7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFN7"/>
    <dbReference type="WBParaSite" id="DME_0000626301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000626301-mRNA-1"/>
        <property type="gene ID" value="DME_0000626301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF7">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000626301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53915" checksum="6EC50286CFF3F400" modified="2015-12-09" version="1">MEKKNSEFTTNFVFGQFFVPHACSVTDLQLRIENMLLWAANGIGMIVGTLPLACLLQLIGGRKFFSKLNFASFFLRSQAHLEFIEKYFIIGIRLIQGITCAGIFPLIGTLSANWSSLKEQFIFLVWGNLFIQAAPLISWPVVSIMLIQHRRLPYFICGGLNILYAFVWFVFYRDRPQYHPWVNGLELNKIVAGKVKVIRNRFSANHPFASLAKSTSVWAIWVSSFGYYSIIALVTQFLPIYYHSVIKESISDSIFLASSSFIFMFFFTIFHSLCQRFYYLCHDKTSVLVANSVSFLVCSMMCIFLALFLPANNDSLSIACCFSALLSFLTLSIYGFYRSAILVGRFYGQYIIANMQIFVGFSYCFVSMAAMFIIRNKFSLFLSIFLIKFPPIRTMKEISSDNFEWRLLFILMALILLLTAATFGIFGSGDVEEWAKDSWDPSAARRMINFDQIDYNNDECGLIEMRLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG40</accession>
    <name>A0A0N4UG40_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NRF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9548</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG40"/>
    <dbReference type="WBParaSite" id="DME_0000643701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000643701-mRNA-1"/>
        <property type="gene ID" value="DME_0000643701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF68">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000643701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28906" checksum="AFDB0FD4056F4B98" modified="2015-12-09" version="1">MNRCFHDLLRVATVASRAFISHMLCKWSHQNATYKQRHCLESWYHSRLWALKIFDSWGRLPAGFYSTGPFFWLGAYDQCLAIENDGRNQSWFTIMCFTLLLTLFFFGTILRFRSHQQRNVYYVEEDHQQESQIHTEYYLTNVSYECNWRNTSISQASSYAITYKSMVALQRTIKKNSLFTHIIEAFGLFSTLHYLFRPSHHHLRSIHGIRAFSTLWVGEISYLQWKNIFYRSKDFLSAIHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG77</accession>
    <name>A0A0N4UG77_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9591</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG77"/>
    <dbReference type="STRING" id="318479.A0A0N4UG77"/>
    <dbReference type="WBParaSite" id="DME_0000648001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000648001-mRNA-1"/>
        <property type="gene ID" value="DME_0000648001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10589371at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000648001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11427" checksum="B19F1BD596852919" modified="2015-12-09" version="1">MNVLLFEEREVCTRCGGDERNCSSLRNLPAAQLQLPPFVYSSHSSSVSPQRTSPSPYTYDYSQVAEERRRICLNNDGRSNSFTSASRIVDNQVSTFTEEAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGJ2</accession>
    <name>A0A0N4UGJ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gypsy retrotransposon integrase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1259</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGJ2"/>
    <dbReference type="WBParaSite" id="DME_0000661501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000661501-mRNA-1"/>
        <property type="gene ID" value="DME_0000661501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000661501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27756" checksum="3E67D569130B8F67" modified="2015-12-09" version="1">MRTAVGPQYSSTAKESRSPREVIHSIIKGQTVHKHQPTARLLGDLRRSPLSSGSDGPSMEEPISPREAEKEVVVPQTQVATVKALDEADEPPKTPKNAVSPDGKFPSWILDEVREVRQSSFYRLDLGLELHTAQTRRSIPGDQGRIVQWCRFPTALKNKQRLTEGFVDCPAYVQMGDRNRRPHSMQAISQTVYFGIRRRAFVRPKVCQTKLCILVRILISARFPDRAIGLSSRPGFRTTFIVGEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGJ9</accession>
    <name>A0A0N4UGJ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1268</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGJ9"/>
    <dbReference type="WBParaSite" id="DME_0000662401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000662401-mRNA-1"/>
        <property type="gene ID" value="DME_0000662401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF65">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000662401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="771" mass="88591" checksum="21D6614B9566D782" modified="2015-12-09" version="1">MWKERLNIGSGGHKIIMVFTDGVEDWPSSILEFRRSSLQDNPVRIFGFAMGYGTGKIPILEYLACNTHATCATVDSIADVKRQSIAYISKLSEILSLAYSKIPPETRPTTKKLRIEHKYHFYFGTPSYMDTQGGGPTVTMSMAILNAMENGSSLLGVAGIDVPFKHFAEILPENEQMYAFIVDNNGIAIYHPQLKIPKTEIYSVRRTACYDKRLKSRGNGRIQFGEADERVLKLMGLTDSIPTIDIAELELSSSKFLEFRKAMIDQNCNKLPFIDVSFLKSDIATISSALSEAMMGTRHYYCRSISGTPWTIGFVVFSDRGETILTKNIPRPTAPTKALVGHYVPKRGLCRGNLDHENKLERFNAFLESEKCEMDKRLPYALASSLNKWTESWPDLEGNATCVNNPLPINFDPFFYINSFVSTLTHITAFYPECSFESLRSVIDLLELDRYPKPTNKLQIFVFNENRTHTVTAYEQIFDSKFGRRLALGGVQWTVSFIGQIFTNLTIHSNEWKRKKRCYLVTMNGFVVAGKQAEQHLSQSDPYLFNYLIKKSVVLKSYRRDNQAQCSPLRTYLLTKSDASTTNFHEISTLLHKFMEIFSSAFWFELWIVLSTLLRNIVSQPVMIGKICQFSRIKHRELCSLEYPVYEMELNHTKRFILNDGICSRLLFIREFWICDYNLKFDALLQLRDILIKPLQDISLYLFIVDNPCNNNFDSSVQHSHTFLPRRGSFRLIFFLYPNARGYDRFTDGEGPTSIIHADIHRKEMRHVRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH99</accession>
    <name>A0A0N4UH99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1524</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH99"/>
    <dbReference type="STRING" id="318479.A0A0N4UH99"/>
    <dbReference type="WBParaSite" id="DME_0000691001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000691001-mRNA-1"/>
        <property type="gene ID" value="DME_0000691001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000691001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35835" checksum="1830E89506D93632" modified="2015-12-09" version="1">MREMGMPAEYINKLYRMLQDIELSKDINNSFKKGIGKNKSERNDLIESVSLKVLNAGAWSRFGEKVQLQLPRELEDILPEVDEFYRKQHNGRKLQWFHHWSYGTVSFSNNVGKFDLDVTTLQLSVLFCWNDRPHDQLSFETLRIATQLAKADLSRTLSWLVAFPKMKHQILLTDCKSMNFRDFTDSTLFWLNQQFAIYKNGKDHSRGRINLIGRLQLSMEQNSQDEHDDILQLRAERIQEAIVKIMKVRKRCPSAQLQTELIELVKNVFLPSKRLFKEQIEWLIENKYIERDPNDFNVFLYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIG0</accession>
    <name>A0A0N4UIG0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED8</name>
        <name evidence="10" type="ORF">DME_LOCUS10031</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIG0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIG0"/>
    <dbReference type="WBParaSite" id="DME_0000739301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000739301-mRNA-1"/>
        <property type="gene ID" value="DME_0000739301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000739301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29902" checksum="FD953E40EA9BF00F" modified="2016-06-08" version="2">MNGTAASLNQKHEGLERFARNDAPSIIFGHQQDITRFNQAVSHIEMKAVEIKNNIEQLLFMLDLQEKVSWPDMLDKFSSLASAMTQLQSMLKKSALPSGTEDYGNLLRTHLLVPHRLSNEIDANLQAMTTNRLHCWNHDAAPEYLRTKLTPEIEADEAHIDTEKNARTFDQVNKQILAMNKHIETLLTSIIENAKSQADAHIDTPTYDNQDTQKLVRAIVNGEGLRPSRSSANVQSDTSHLGTASNSASSTHVANRQPMGMVPQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIL4</accession>
    <name>A0A0N4UIL4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Thiamine transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10018</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIL4"/>
    <dbReference type="STRING" id="318479.A0A0N4UIL4"/>
    <dbReference type="WBParaSite" id="DME_0000744901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000744901-mRNA-1"/>
        <property type="gene ID" value="DME_0000744901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18814at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000298">
        <property type="entry name" value="Thiamine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF20">
        <property type="entry name" value="FOLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000744901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48410" checksum="7C6D799EFDDA5813" modified="2015-12-09" version="1">MHWKATTTLICLYGIVKEFRPATPFLTPYLVSSFKNFTNAELYSQIYPYWTYSYLVALIPVFFLTDILRYKPIIMLEAVSLCATWALLVWGKTVWQMQIMQIAFGISSASEVAYYSYMYAVVTQKHYARVTSYLRAAALAGKFMAFALAQFLISTGYGSYLLLNQISFCALCLVLFIALILPSIPSRIIVNKIGEGTNNVRRNSRETVEWNETQEETYRIAAYFRAIWNHMKIFKRNKIVLKWSIWFALATAGTYQVYNYIQTLWSIMQNVDEKAANGITECANTLIGALLSFIVQYLHVNWVKRGESVLFISSLVAGLLLLLASQITSIILAYIIYVVIASIYHLLITAASANIASELDSATYGLIFAWNTFIALTIQTAITFAVADEHGFALGIRDQFIVYGGYFVGVALLFMVLIIWKSIKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ41</accession>
    <name>A0A0N4UJ41_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1922</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ41"/>
    <dbReference type="WBParaSite" id="DME_0000765501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000765501-mRNA-1"/>
        <property type="gene ID" value="DME_0000765501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000765501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9480" checksum="9CA943E855473F48" modified="2015-12-09" version="1">MRLERPFEIKQLLEEEFWWTVILFESQSNHQNYIIRKVKIFTPLNGIIFYTVAASLSSGPSELDGPIGPSDLAAPSGSIGANTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJD4</accession>
    <name>A0A0N4UJD4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1961</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000039">
        <property type="protein sequence ID" value="VDN51988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJD4"/>
    <dbReference type="WBParaSite" id="DME_0000776401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000776401-mRNA-1"/>
        <property type="gene ID" value="DME_0000776401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912142at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000776401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30981" checksum="F906E27AA1876D77" modified="2015-12-09" version="1">MSPTRNGVPRQSSTSDKAYNLESPKVPSPPPVCCKVPTPNISSSSVSGVSSSFQMKPLTSPKLPLFIPPTQVITKTSPFLSMFSKKKRINGTKSADNDIKVASVALFDPSTANDFIDSDKDSVINDNNYHFSRNFNNKFNSLNESTDKNNDNIDNNGQLLMNQSNLKFFKKKKQSKTSPNYRTTKDIKKSYLKTSHSFESVTSSSSSSLSPTSLSLSALSLSDPHLMEALEILADMPPPIVARSIPKHATIDTTNFVNRSLDNCLFDSSVYDGMLFDSLKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI5</accession>
    <name>A0A0N4UJI5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10194</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJI5"/>
    <dbReference type="WBParaSite" id="DME_0000782401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000782401-mRNA-1"/>
        <property type="gene ID" value="DME_0000782401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327:SF7">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327">
        <property type="entry name" value="SPERM MEIOSIS PDZ DOMAIN CONTAINING PROTEINS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="91"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000782401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26975" checksum="4E5AE65ADE484B69" modified="2015-12-09" version="1">MAKKITVVVPIENGEPLGAIPDEKLVINSVQPGTIADGKLKVYNIALGKIDDPKSLIVLKVGDQILKLNNTDIKGLNHFFHLLRFAPPSAELLILRDEKKAEELAAKINIPTERTKYITHFQNRVLVSRCEANSLSAGCLKVGDHIIDVDGQPVSNKKVCRDLLLIRNFVTLVVERPESMEAKYWVQNALTASTLPSVSMSSDVQEIAARQREKMKMNLKVRLAPPACRTRQIFEMFLPISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK28</accession>
    <name>A0A0N4UK28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2176</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK28"/>
    <dbReference type="STRING" id="318479.A0A0N4UK28"/>
    <dbReference type="WBParaSite" id="DME_0000805101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000805101-mRNA-1"/>
        <property type="gene ID" value="DME_0000805101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF944">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="218"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000805101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121240" checksum="8508F334455DB23B" modified="2016-06-08" version="2">MTILSVAGSKGRVQAGGDLFDQANSSSNVFLSFYFNSSFLIFKVGILTANEAELFNSVKRWLGDVNERILIHVIKNHSTSVQSQFGGNSESLMNDIIGSYFDKIQPDAERSFKQVRFDENSKNSPQNASLKRPSSFTSCGTSTDKAVVVDLTLEEDRGSLKWKNSMTNNVIGSREEQDVIKAIEESLKENQNVPGFSPFAQKDAENPHERKRIDLMPVGLKNIGNSCWFNVIAQTLFHLPRFRQLLFEFTAKEFWDEGDGFTERPSSSKEVTPSDLLFAFRGLSAMLLASTRAYVDPTDILQTINDLNTNLNKTVPCIGIQQDAIEMLLRLIEWLEQAFNACDIANCAPLDAEMEEVSCFKAKEESNAVDEITDDGANAPTTSCVLRPFNSLLHGSHIELRQFPAMLKSIFMILDGVITRSVLENSLQMINLDVSFDNLHDSLEAYHFNDYPSKEVIIFHFFYKLLLFFLNVWFENLPPVIIFSLVRFSYKNGQTEKLHSKFHFPLDFFMDRYLHRNRTYVNIKRQERMILKERLENLKNELRRLCFIHCIKFSRRTLLPSWGISAFGFENNEGSGHMEDHSNEFKPAISKELVVLDADAVARFLLQISNDVNAKIIGLQDEVNSLQENIDATFNVENMKEEGYRLHSVIIHEGEANVGHYWAYIADHSTLDENGSPVNWRRFNDKSVERATWQQIEEDSFGSRRTCSAYCLIYTRKRLEQELFGQGGNTASSTIPHLLDTLPIDLKQLVAADNDKFNKELESWDSKILPIECGPINRPVLRLPVDSEIADMLGVSKPLDLMNISRRHCECAFHYFGNAMLQSALKMLYDKTLDNVDDAKMIFNELLNNHICHINRAIELFAKTSNMDRLLILTEWARLFGFSMSKEAEKLFIVQVLSKLDEPNLQSLCKAYKSERGLAGNNNPVIDELDVCLFLCGLFIMTYCKAGVYVQLFAKISQDILHSISASNEKIVVEYDNFLRTEYRAMLSRLRCYKGEAYEQVVVNGCSKSNLSEMPFIHCDIKDVSVAKDLISLKQYMMKVNLNTVDDLLITVSMLIKQESVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK72</accession>
    <name>A0A0N4UK72_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10236</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001208">
        <property type="protein sequence ID" value="VDN60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK72"/>
    <dbReference type="WBParaSite" id="DME_0000810001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000810001-mRNA-1"/>
        <property type="gene ID" value="DME_0000810001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000810001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9237" checksum="7BD696DDD261162B" modified="2015-12-09" version="1">MGELAIAFMPNMLITFINLLYFIDYSEGGGVNIVACSTGGATPRPTIPPEYCQDSDPACPILFPLTAAEIEQNLNVLVFSQIFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKY5</accession>
    <name>A0A0N4UKY5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SelT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10370</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKY5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKY5"/>
    <dbReference type="WBParaSite" id="DME_0000842601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000842601-mRNA-1"/>
        <property type="gene ID" value="DME_0000842601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041686" evidence="3">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000842601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26163" checksum="A9A5ED779B55BE50" modified="2015-12-09" version="1">MVLNQFGCLILASALLLSLSDIYGHLENENDVDEDSFKKEFDDEDGTPKNGESIEDEEIHIRKPSSHFTSSHTIKKLPEMKFLFCVSCGYRQAFDEFSRFIHEKYPAMKISGSNYSPTAWKSIIAQVIGFGKIALIVMIVMGTNPFSASGMETPRIVNWAFSNKLSCCMMLFLISNAVESSLMSTGAFEIFLGNEQIWSKLESGRVPSPSELLQIVDQHMELQGAKVSDTFTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL39</accession>
    <name>A0A0N4UL39_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2467</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000062">
        <property type="protein sequence ID" value="VDN52494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL39"/>
    <dbReference type="STRING" id="318479.A0A0N4UL39"/>
    <dbReference type="WBParaSite" id="DME_0000849201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000849201-mRNA-1"/>
        <property type="gene ID" value="DME_0000849201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000849201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8455" checksum="B8F09FC34F07DB96" modified="2015-12-09" version="1">MGPNQAGFRPGRGCADQIFTLRRILEHRFRYLQHTVTRFIDFVAAFDSIDKAVLWRVMERNGYSLIPLAEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL63</accession>
    <name>A0A0N4UL63_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10386</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL63"/>
    <dbReference type="WBParaSite" id="DME_0000851901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000851901-mRNA-1"/>
        <property type="gene ID" value="DME_0000851901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000851901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24414" checksum="2398BBB93460E649" modified="2015-12-09" version="1">MLKTETVNGSWTLFECVGQLFGHGPEELVEAIRKGLQTQWLMLKKLRRSETISELTEIAQARTLLGIHLEALCRVKNVQVMFIDLKKKNLVFGNTGPLYEILRNGESFTYISGARRTWVSCFAELQNLSVIEEPSENFVNSPIYCIDEIMQYDLNEEWSSNSMSLLMPPLNAVAEEEIEDISKPNMNPGISHIVLSENYTTVYGANQNESPSYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL75</accession>
    <name>A0A0N4UL75_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10400</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL75"/>
    <dbReference type="STRING" id="318479.A0A0N4UL75"/>
    <dbReference type="WBParaSite" id="DME_0000853301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000853301-mRNA-1"/>
        <property type="gene ID" value="DME_0000853301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875790at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="109"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000853301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33091" checksum="1AADAF989100FCB9" modified="2015-12-09" version="1">MMDILDHEGSLFNKPNVISVPITMYNIYPRVYGTDEIYDRFEIFCKNLEIIDELNSKNNSVIYGITKFADWKDDELKTNNVSYIKFDKMDTRFMYSNWIHLKWDGKTKIPISWDWRDLRAVTHVKSQMAAVVESLYYLKYGRYISISESEMVDCDHMNEGCVGGNTKHALWRGSYKGFIQHHDYFPSPLGHRYYCPKYSTIFLDKLYFIHPDENSIAWFISYIGPVSLNLAMLQINKLYKGGIIMDSKECREIIPNHSAEAIGFGEENGTKYWILKNSWGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULS3</accession>
    <name>A0A0N4ULS3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-binding protein 5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2652</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULS3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULS3"/>
    <dbReference type="WBParaSite" id="DME_0000876101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000876101-mRNA-1"/>
        <property type="gene ID" value="DME_0000876101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000876101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51413" checksum="411C4E437D70A4F1" modified="2015-12-09" version="1">MFLKDEHIEYAINDEIPIDAKHLNRVHEELEKLNIATDIINKLELQLDEARDTFKSTQRFWSQKLNELNKKYGSAIENGRPYYEAKLEERQLREEAQNAAVRFERATSMHTIAKQQVKLTQDSLSRQKGIRPECLEVLNHHIQRVNEAEEERSAAEYVHRSISTKMSDCAQRIASIEKTNSRAIKKSKRYFEQRIEFTRILEQQKNFITKLEAEVRQKKADYNISLRNLEQISDAIHEERSITSMRTDSSPADRFINEKTRSLENNVKMKENTDKITITQKPVVLDDIKCKLEQMTLDYDQSDLAVFDSDYNSNEESNNNEMKIAGIGSGVILLAQQLIGGNEKSRKGKKAKVLPSSVPSFFHDLRYRTTLPEGVGYNTSLSSAETSDSEGSLGSSRTDANTVNTDELSGMIRSHSQLIEEIDDCAERTKNMLHGSLNNLELECSGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULU1</accession>
    <name>A0A0N4ULU1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULU1"/>
    <dbReference type="STRING" id="318479.A0A0N4ULU1"/>
    <dbReference type="WBParaSite" id="DME_0000878201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878201-mRNA-1"/>
        <property type="gene ID" value="DME_0000878201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18666" checksum="B78EF8D5BF8C632E" modified="2015-12-09" version="1">MVDKGNNGDPRKNYILRIASHLFALNVNENKLQNLNAIQKFCDTNASLLIVEKNETNGSVKLSNELINDNVTISNVFRIIFYKIKSVPLTIENYKKEISLITLQSDSSEEGFLNSIRQLRIAVNWSFSISAGRTCLKSASPDQLRKLDIFSASDMCNENAFIRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULX6</accession>
    <name>A0A0N4ULX6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS2699</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70244"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULX6"/>
    <dbReference type="STRING" id="318479.A0A0N4ULX6"/>
    <dbReference type="WBParaSite" id="DME_0000882301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000882301-mRNA-1"/>
        <property type="gene ID" value="DME_0000882301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000041">
        <property type="entry name" value="UDP-glucose ceramide glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041047" description="ceramide glucosyltransferase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN52726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000882301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43365" checksum="061CE92B4257FBA8" modified="2015-12-09" version="1">MLSAIWLCLLVKCHLHRNLIASNEFPGVSIIKPLVGTDENLFLNLESFFKLNYPMYELLFCLHSDNDPAQKVVEALMLKHPHIDAQIFIGGEDVGMNPKINNMMPAYRASKFPLILISDSGIYMREDALMDMVIAMKEDVALVTQMPFCMDRFGFGANLEQVYFGTSHARIYLAANCLRITCSTGMSSLMRKNCLEEAGGMEKFSDFLAEDYFFGVAFKKRGWKITMSSLPALQNTANPDPNKFHSRICRWIKLRFAMLPHTILLEPLQDCFVSGLLGCGSILILLPTYPTLAMYFFIFHLIYWIVCDYILIRIVQNGPLPFSFAQFLFVWLYREGSAFPTWCSALINPTVKWRSSAFRLLWGGRIQEQSLPVTKWLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULY8</accession>
    <name>A0A0N4ULY8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10491</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001220">
        <property type="protein sequence ID" value="VDN60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULY8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULY8"/>
    <dbReference type="WBParaSite" id="DME_0000883501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000883501-mRNA-1"/>
        <property type="gene ID" value="DME_0000883501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000883501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34198" checksum="15CABB8A9D629044" modified="2015-12-09" version="1">MFDFDWQPFSINRDNFARISSSSSPSLPESIDGYHNSAINFWSGGIDGIIRNRTLIKNETMTTVWTVDELKTAINDLVNNIVKISMQYNNHSAALNQQWALELNDLLKKFNNSVGSLPNVQKNRYRQEFSEKPIIDCVGEECHGKRNGSFERFINPTFPAVKIHVITTTSSWLSRGLGSLESLLPTNLNFTDQLSQLISKIFSNLENDSSDDKSADFSGFRSVEPLVKQSVLKSIYQTVINEGEFPIPTVPTVTVYDTWPNNTWFWIWHALGVVIIIALIISIIVLCLKMRKRKQYERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM00</accession>
    <name>A0A0N4UM00_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2707</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000076">
        <property type="protein sequence ID" value="VDN52734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM00"/>
    <dbReference type="STRING" id="318479.A0A0N4UM00"/>
    <dbReference type="WBParaSite" id="DME_0000884701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000884701-mRNA-1"/>
        <property type="gene ID" value="DME_0000884701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000884701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36222" checksum="66CEDEB72A840F64" modified="2015-12-09" version="1">MNWYCFIFFIYATICQRCPKLFGEFECPIGHNCIDNQCLSPDGRSAPIECDKIQCPTMTRCYKGRCYSTIGLFCNRNVQINKTTAKSVLSNCGQFGKCINGHCILDRCANISCETTEQCRDGICVKIAGTFCLSSFDCGPNYDCIRNTCIKNHRVSCNCDPGESCQQGHCFADPTVFNLFLSECAHVTCTNGSFCFDGSCVSAIGRDCLQETCLGGTVCINGRCSLDPCISRCPVDHDCREGHCRHLQGLPCVNECPYPYECVDGRCTRNECFQKLCLPGEICDYGFCVNVEGRLCSLAIRDCGQDFECESSFCKDKILLQGQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMH1</accession>
    <name>A0A0N4UMH1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2836</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000083">
        <property type="protein sequence ID" value="VDN52863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMH1"/>
    <dbReference type="STRING" id="318479.A0A0N4UMH1"/>
    <dbReference type="WBParaSite" id="DME_0000904601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000904601-mRNA-1"/>
        <property type="gene ID" value="DME_0000904601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000099">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="370"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1376"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000904601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1427" mass="160953" checksum="EA714F37BFDE5355" modified="2015-12-09" version="1">MVNDEISKSQETLTFNGLSQESQDRSTHSMNDDGLENNVASGNDSGHASNSNFSSPVSPLTPDGERASSPGAFIIIVEKSVVDETASCLNDSSFHVRIVAPGCEPFDLQVVLNSFSIYSFFLQKNLINLKVNAGELVQEIHQILLERESTCHRTCFSLQLDGVSLDSFTELKNIAELKDGCVLKVVEEPYTLREARIHLRHVRELIRGGETVDAVNGIDGASLSYLVTMLIDRKKAFDKSVVCSPPEYIMPGYKERPLVPLLPVNKDAISAGDILYLTVDTLEGRRYHITCCTKGFYVNATAEGIFRPAPSQSHKTIYHSLVDLLSSISAQFKKAITVLLKRRAEKQILERLPTPYQVVSWVTPSFEQTEDDIRAEDCTQPHRIGLEDHIPGQNRDWNEELQTTRELPRETVTEKIIRERAIFKIHSDFVFAAIKGAIAVIDGNVIPLNPSEEPRTRMYIWNNIFFSLGFDVKDYYKESGGDAAAHAATSNDLQGVHAYAQLDNPKLFTVGMVIIDYKGYRVTAQTIIPGILEREQEQSVVYGSIDFGKTVVTSEKYQELLEKPAEQLKILPHNVKNGKEDDKILRLFSSIETKGIIGNDSRHYILDLLRTFPPDVNYLEGVQVTDICKNSGFPRQFPHKLASLRQELVDAFVEYRYLMFIRIAAYQIQRMRINLSGESSGSITENSFEIQQKSENSEEKNEIAIDQLKSETVDGKRQDDLLLLETEIAKKIFDETIEEEVIDSRLDKNISKQIISKAAQDVGSVCSDAFEIRFNPDCFCSTVKHADNEDLAKQRLLVAEAAEFLIVHQLPNFVRDCLQHAVLPIDGISLIGALHDRGINVRYLGRLVNYVQDVEQLAYLKSIILLIQEDDITVLNTQIETRPLIFSTYLFQVICMIELICRSAKHIYRGYLQPVTPCSIAAAVAHFLNCLLSSTTNSVLSNDETNSTFNGSKRTKGARRRKQSNGHIKGCNLWANMSSKILWENLLNEFCSYYAFAINCQNIDEFLRQNNLQKTSILRRFAQMVGIQVLLKDYNLESGKKSPLFLEDDIQNIYPVCKHIDPRAIDANNMFIAGQAKVQQGAMRVGYDMVAESLNLMNNIYGAMHVEMGQCMRLLARLSYIMGDPAEALAQQHKATLISERCSGLDSAITITEYINLAHFSFANLHIVASLKLLYRARYLLLLVHGENHPLIAQIDGNIGVILYAVQEYDDALKFLQNALKLHQIYSEPLALKTALIYHLIARTQSCRGDFRSALQMEKETFSVYSKTFGEHHEKTKESSEFLKHLTQQAVNFQKRINEANRQGSSNIGQLLPVEVVILLFFNILINIIMISKYLKIQSLIEMVHRPSLQSILEVLNIINGIIFLHLKNPADGKDLEPSKNDCKPHYKSESDQLPSRSKEGSDLRSEILNVPCSKTLNLKIQEEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMP6</accession>
    <name>A0A0N4UMP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-carotene 15,15'-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2869</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMP6"/>
    <dbReference type="WBParaSite" id="DME_0000913201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000913201-mRNA-1"/>
        <property type="gene ID" value="DME_0000913201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851048at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000913201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66113" checksum="8CA9063AFCB61E87" modified="2015-12-09" version="1">MERIKRISYALIFIGTLNILNGFIASCIQAEKSYHTKYFVNTHWITSIIVFAGISATLCKSFNSITNLLIFAILCNSIAFLIASVAVIADFLNIVILIRDFDSLKANKLFTIIQVYAMISYSLVDLLLCILAVMLMVPILTLAVQRIVEYQLEKNSKFALCIGISLFVTSIFKLIVWLFELFLVRSLGSSLRFSFMNYTIDEPFWIVFNIAVGIVCMLSSQRGAILRTITICFSAISLHPTIIILWIDYRWFSRLFAMLVSILLLSFDIISAKLGAFYKIFQGTEQKTPFLLAIISALLILLTMTETSSSIIPAALVFLLFCIQSTSFNIISYAYLSWNGYFAANLCELFYQNSIGCTKLVTKIGSFAHFFENLMHLLVLTGSIILVLLLWQLMQINKTRSHWLRNSQKQLVHKYEIIIKTIGLIGLLCGTITLLFTVHDFINNRIRHPLLVILSHLYHISLAITLIIFPLYQVIVSKTLFKNRLSYLSLIMVNALRFVEILTQLDYRNIGESASWPWKIHTTVETISLAACFVTIVLCLRIIDILSGNITAVDLPQSFTEFSNPLSAVRNSDGYTQMLSDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNG5</accession>
    <name>A0A0N4UNG5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3143</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000108">
        <property type="protein sequence ID" value="VDN53170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNG5"/>
    <dbReference type="WBParaSite" id="DME_0000944701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000944701-mRNA-1"/>
        <property type="gene ID" value="DME_0000944701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF1">
        <property type="entry name" value="PEZ, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="343"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000944701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47678" checksum="41AE4CAC09C1C698" modified="2016-06-08" version="2">MYHKNLLITQVEQLSYQKEKKVDYQELKSTKYEQTKTASEDMRSDRMRHVLLNGVVNTNKKPYSFNSGLISSTNDETLSKLIEKLSAEDTLNEEFTLIPTKRMSAGVSTSQKPENSKRNRTRSIVPYEENRVMLHSTKNNATGYINASNVQMPIGNQMLRYIIAQAPLKDFLDDFWQMIWESGAQLIVMLCEAEGDGATSTPYYWPQKVKSKMRLVDYDITLVSTTSSNISPQTTSIIEIKCTSSGEKRTIYHLRFHNWLTGSIPDDENAFLAFIDTVNSVRRHLDNERLKETDFGALLTQNEQERCRNMNRANRVGEKIQCSTRSEISSESSSSLNTTISLDSPPLVIHCLSGAHESGVYLLVELLIHSIENNLSIDVGKILEILRQQRMCLIKTVSQYRFVYSVLINYLEKSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPX5</accession>
    <name>A0A0N4UPX5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3581</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000152">
        <property type="protein sequence ID" value="VDN53608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPX5"/>
    <dbReference type="STRING" id="318479.A0A0N4UPX5"/>
    <dbReference type="WBParaSite" id="DME_0001003701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001003701-mRNA-1"/>
        <property type="gene ID" value="DME_0001003701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001003701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="41077" checksum="A8D1BC08230B390C" modified="2015-12-09" version="1">MAHFHQLCRFYDFFSNDHLEGFHWLRLFGKLGALQQLDRLSPKILPIVYNLTVEFTVRQLKERFGVRSTYENAVKETKAVLNARRLDAEAVFSREQKITLEAEIRRIRKKRMHALHLLIEKLTNDELDVRARQLETSHAMLCKQHEQTKELEITQLNENQSLKRRHMEIQHEAETSNQIQYNQRVTDELNKRHTLKSKQQPKELKAKELMIRKQYRQAVKIQLRQSKILQQQVLSSIPKEEHREMIFKLKEEQKRKLATLAGQYENTIESMVQDLTVKLESWQEDEAKALKERLDKELNMLKDYQRRQKNCLEDNCERERQKLYDRISIRKDVLDGKVEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQE7</accession>
    <name>A0A0N4UQE7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3737</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000176">
        <property type="protein sequence ID" value="VDN53764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQE7"/>
    <dbReference type="WBParaSite" id="DME_0001023201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001023201-mRNA-1"/>
        <property type="gene ID" value="DME_0001023201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042311" evidence="1">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001023201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32017" checksum="BDA488562EAAF594" modified="2015-12-09" version="1">MFPSAVTFFTIVFLQYVSAASECKHGECAYGEEIADFGCRRTNQKCGENMRFSSSNEICWLRCECKNEKYIGKDDKCIEIHQQTIARNNPTTIGFEKSSTISSHNINSASNNVNFASNGASSYDKSVCLMMQGRKCGIHMIFREIQPSNSSESFSSNDKICWLRCRCENESYTREGEKCVEIQQRTAIANNPTAVGEIPIHSHSINNERNYKVGDQIFDFGCRRTNQKCGTNMIFKTISKVLLLEYPQPSYRCFQKCSCISEKYIENDGECREGRHKTEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQE8</accession>
    <name>A0A0N4UQE8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10856</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001260">
        <property type="protein sequence ID" value="VDN60883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQE8"/>
    <dbReference type="WBParaSite" id="DME_0001023301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001023301-mRNA-1"/>
        <property type="gene ID" value="DME_0001023301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001023301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23648" checksum="483353297DFBE630" modified="2015-12-09" version="1">MCGVRECIDPYRSSFATLPRFSTSSERCASKCMQTHLCALNEKIEDVKCKLTGKNCGENMDFVTVKRNVIPISSLSKNYQLEICIQQCKCVENNYIEKDGKCFMNSTIVTTIHHNDHFYGEELLDNSCRLAESKCGLNMIFVNINPVRSNFSDLLKFSSFDFCVVKCKCMKTFEEKNGKCIRNLSRISKNHNHNRNRNPNRKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQF1</accession>
    <name>A0A0N4UQF1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10859</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001260">
        <property type="protein sequence ID" value="VDN60886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQF1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQF1"/>
    <dbReference type="WBParaSite" id="DME_0001023601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001023601-mRNA-1"/>
        <property type="gene ID" value="DME_0001023601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057585at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001023601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47084" checksum="24ECDA240ED58960" modified="2015-12-09" version="1">MTSKGKEIYNTIKRSLSSTASAVATSSSMSNHSRYVAPSVKQWIHPPDILLNGRVEYSVKMLGQIEVKEAKGTHVIRDAIHAIRFQLQVNRGVTGHSGAKLKKVDLHINVDGVTIVDNKTKMILFKYPLHRISFCADDKQDKRVFSFIAKAESSSRHDCFVFLSEKLAEQITLTVGEAFDLAYQKFLEKNGRDLENRKQLIVLRKRIAELETENNELRIKLAEALKKNSVNGNIYAPSLPTTPMPSEPPSSVSSNNTIPRALIPPPSFSKRQNIAPNSLASELRSSGPCVGRKLENLELDKMEDIFDNQFDPRADERKKKLYEKTKKDKFGLDPFGDDFMNEVLNMEPNTGRNDKNVEIEPTPEDLEKMLSMVDERLSELRDGFASGVLAMGDTGDSARDLHNIYSVPQQSSMEEESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQY9</accession>
    <name>A0A0N4UQY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3909</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000215">
        <property type="protein sequence ID" value="VDN53936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UQY9"/>
    <dbReference type="WBParaSite" id="DME_0001045501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001045501-mRNA-1"/>
        <property type="gene ID" value="DME_0001045501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836328at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041708" evidence="2">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001045501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18903" checksum="C12963B69107F074" modified="2015-12-09" version="1">MYFLTLMILTILSQIELLFGAANADGPCQTGAIGELCENEEKNEGCNLVFPDAPVVNNNKVSDNCPLYPLLAEKCRKRCLSCCLQPEYACSDNPAVLPFTCVEAKNKNLCKTTNPAMKALIEKGCPQTCGLCATNNCTDMDPLYCSTNYVKCDDANTKAFMAEYCKKTCRTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR03</accession>
    <name>A0A0N4UR03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3923</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000219">
        <property type="protein sequence ID" value="VDN53950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR03"/>
    <dbReference type="WBParaSite" id="DME_0001046901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001046901-mRNA-1"/>
        <property type="gene ID" value="DME_0001046901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039260" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001046901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14482" checksum="4D1BE1A840F7F3AC" modified="2015-12-09" version="1">MLFMWLILHQLFDFCCSGYEAIGDCFKEVDINDAASNETCQLLIFGRDCKNPNLYPIILARCPATCGLCDQPGVLGECPDRSDNCATIIGLDPKQCNKTSVANMCMKSCNLKTCLSGKCELKESILTAGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URJ1</accession>
    <name>A0A0N4URJ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTCK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000281">
        <property type="protein sequence ID" value="VDN54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URJ1"/>
    <dbReference type="WBParaSite" id="DME_0001067301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001067301-mRNA-1"/>
        <property type="gene ID" value="DME_0001067301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001067301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34492" checksum="F31C0B867E884D80" modified="2015-12-09" version="1">MRKIPADKQGNLQRISEILPKYCAGRLCALDEKIFDPLCLLTGGKCGKNMVFKTVYRTLRMGMSSMLSLTFCIQQCTCVNKYVKKDGQCIKQNSFPVRNETEFRAEILPKRCTGRECALDEEISDVSCSLTGKMCGTNMIFDKVGKSNETNVPCSLTGKICGTNVIFDKVSKSYGTNGTKICVQRCTYLDEEYIKAIGQCILPAKGKKTTTPILTQRSAAEYPQLPLLETRANCEGRSCEIREPLCTLTSRKCGHNMVYKTSERLIYIDGHLEICFQQCKCISEEYIEKDGRCIKKERKENETQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2J3</accession>
    <name>A0A158Q2J3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malate dehydrogenase, cytoplasmic</fullName>
            <ecNumber evidence="2">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4603</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2J3"/>
    <dbReference type="STRING" id="318479.A0A158Q2J3"/>
    <dbReference type="WBParaSite" id="DME_0000024301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000024301-mRNA-1"/>
        <property type="gene ID" value="DME_0000024301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000024301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30680" checksum="F54CCF2BEC23C8F4" modified="2016-06-08" version="1">MYRVLVTGAAGQIGYSLVMQIAKGDVFGPETPVCLILFDIPMMHDALTGVQYELQDCALPTLKEVKVTVDEKEAFEGIDYAFLVGAMPRKQGMERKDLLAANVKIFKTQGQALAQYAKPTTKTGEVKNVIIWGNHSATQVPDVGHATVLKDGHAVKAYDAVNDTEWLHGPFISIIQKRGAVIIEKRKLSSAMSAAKAACDHVRDWHKGTREGEWVSMAVPSDGSYGIPKGLVFSFPCRVSGGQWSIVQGLQWSDFIKGKIEITRKELEEERDEALKACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2K4</accession>
    <name>A0A158Q2K4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS4668</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2K4"/>
    <dbReference type="STRING" id="318479.A0A158Q2K4"/>
    <dbReference type="WBParaSite" id="DME_0000030801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000030801-mRNA-1"/>
        <property type="gene ID" value="DME_0000030801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000035">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="14">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="15">
        <location>
            <begin position="200"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN54695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000030801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43890" checksum="464562E26E0EAA71" modified="2016-06-08" version="1">MLPDIEDAVQVSIEMHVQDISSLNEITSDFEIDILFTQLWHDSALSFSNYNACKRNITMESKFIDLIWTPNTCLINSKNTMIHSSPTDNVMFILYENGTVWINYRMSVKAPCDLDLRTFPFDTQSCVLIFESYSHNSEEVTLRWMNEPITLMKPIQLPDFDMIFFKTNSETMLYPNGYWDQLQVVFSFKRRYGFYILQAYVPTYLTIVVSWVSFCMEPKALPARTTVGVSSLLALTFQFGNILKNLPRVSYVKAMDVWMLGCISFVFASMIELAFVCHITRCDNDSNRSSRNNLMQKLNLFKYKHNGTCNSDRYNTGKCLPICHLTLKFIQFISTASPPWSRRFYLHPETVDKFSIVCFPLTFTLFNRLHFASNIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2N9</accession>
    <name>A0A158Q2N9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4902</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2N9"/>
    <dbReference type="STRING" id="318479.A0A158Q2N9"/>
    <dbReference type="WBParaSite" id="DME_0000054201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000054201-mRNA-1"/>
        <property type="gene ID" value="DME_0000054201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515799at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000054201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="794" mass="88945" checksum="2A80345F0BF94A2F" modified="2016-06-08" version="1">MIVVDPISQQNNFTGGDTVQIETNSVNSSKKRLVFKTPIVNLTKPCITQPSTSSSFPDGDSSLVLNNIAQNSEMNEAFTNDAPKSVKICNDSEHSSQGSPALKSVRKTAHGESEQQISTVSVSIPTSIVKPVRKWGQWNYPETMIFYEGIKQFGKDFELISRLMLKRKMNKDKEQIRNYYFNSLKVLRSTARIDGESLFIVPRDAKELFIVINGFEWKKKVGNKFDSAKLRQLILEGNTSVRLKRKKQFRTVRTPACPALEKLFPSRSAKIALPSHIVVRLHPKYSMDRMYVESCGQNPFIKIRLPIEARLERIFTILNAKWIPKAKKDHYEDIVDRPNIALFPDNTTRLERVMVHCTEEIASSGFSLNRLKSEYEKIKQLSSQKEAKAQGQDMKEPNATTTQFPLLMNYDDVCKASSSVEKTSTEKDVPNNLVHGSVDNQSNSTILDDLKLRNGLTAKSVGDAACGKTKEILMQYTVNVNRNNSVEPWNIFINLLHRNYGDNLCKILSEPADCSMEARTVNVVNVKDRPRKPRIIKSTDDPNPVSSTAPLNNSESSTKMPAETIISLVPTIVQAENDAFIKQLQSLQMSRKRAKPLVERLRAKVKFSSHFLTKLAKIHRGIKIVARGPFPSFAHGMQCSWANNYQYEQTNASTINSSLAAFNNSIVEHFDSQVIRGNHVPDNFHSPNGSISTTGQRNTALGCVNTPVRCHVSAGAAGSNGNIAGEILNGLCSNDFHIDTNTNDTNSLLSNKSIVSLPEDFRQSFDLMMQQSSVDYCRTFEDLQNIALNDSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2Z5</accession>
    <name>A0A158Q2Z5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5599</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2Z5"/>
    <dbReference type="STRING" id="318479.A0A158Q2Z5"/>
    <dbReference type="WBParaSite" id="DME_0000123901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000123901-mRNA-1"/>
        <property type="gene ID" value="DME_0000123901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5797723at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000123901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41963" checksum="E60A4971CB22BC65" modified="2016-06-08" version="1">MWETYLLASAYVLTVKVGVCGNLWAIGTVLRNRRPYNNIMRMSPSDRLRIYISILAIIDLIVTLTLISRIIFISTSNLNFDFGCRLNFIIEHPAKLASLTCLACISVERYITVRKPFNSEIRKQLLLIVPCVAVIIYLITLAALFIEFQAITLADNQFDCTLRIVYLSGFIARLITAIIFLSLLAIVSINYGQIVRHVRRKFSKRKARGYKVISPPRYMRQMTSTIIRVAVFHVICWLPSIISYFLSNEIFSMVTVSVRLLYNPNSSSKYLQNWFALVISWLTYVNSAFNWILYAAMNKDLQMLVRANTERRKRSTLSQISSPFTTKRPFYNSLRILHANSPNRKSLEDLTMSSSNSGFSFRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3A9</accession>
    <name>A0A158Q3A9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS6386</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Golgi apparatus membrane</location>
            <topology evidence="2 14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3A9"/>
    <dbReference type="STRING" id="318479.A0A158Q3A9"/>
    <dbReference type="WBParaSite" id="DME_0000202601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000202601-mRNA-1"/>
        <property type="gene ID" value="DME_0000202601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159198at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23439">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000029">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 14" id="KW-0430">Lectin</keyword>
    <keyword evidence="13 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="521"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN56413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000202601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="667" mass="77875" checksum="6FD4F95A9DFC980D" modified="2016-06-08" version="1">MGVFAGYAGRRLTRILKYIFYIGGFFFIYSFYVVPTVQFLINRGEQSENNKESDNENLAEARMFVRVICFLNSTFDPKSIRIFVKLNTEYANDSTKFEEFVWFILVCNLDKSMVDPFESYRALPKKDWHDYEAMKRDKKRQGPGEGGEQLLPNLDFADSARQESLYRANGYDAYVSDLISIERSVKDIRHVDCQRMQYLEKLPSVSVIFPFHNEHNSTLLRSVYSVINRSPKNILKEIILVDDGSTKSFLKEPLDIYLKEANLDGIVRVIHNKNREGLIRARQIGAKNATADILVFLDAHSETNYNWLPPLIEPIAMDYRTAVCPFVDIIDCNNFEYRSQDEGARGSFDWQFNYKRLPLTKEDRRHPVRPFNNPVMAGGYFAISKKWFWELGGYDEELAIWGGEQYELSFKIWQCHGRLVDAPCSRVGHIYRCKYVPFANPGIGDFISRNFKRVAEVWMDQYKEKLYERRPGTSNADEGDISKQREIRDNLKCKSFDWYMKNVAFDQDYYYPFVEPTASAEGELRNIGSDKCVDAYYHVDNERVELRDCIGDKTGVRAEQTFRLTHRLDIRSAHRPDCFDVSTSDEAAPIVMYKCHGMHGNQRFNYLPETKQLFHPITNHCLDCNPEKGELFMNPCDDKKKSQKWSWGRLNLDLIRKRNQIASPEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3R8</accession>
    <name>A0A158Q3R8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7196</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3R8"/>
    <dbReference type="STRING" id="318479.A0A158Q3R8"/>
    <dbReference type="WBParaSite" id="DME_0000303701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303701-mRNA-1"/>
        <property type="gene ID" value="DME_0000303701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63175" checksum="73D697DE363B63A0" modified="2016-06-08" version="1">MSDDERKRMIIACGTDLRQIIPAIDNEYGLLKESLHKHRLYRQFMIKRTKGIEQIAQIHEKTKIIGEEIDNIRLDLGKIIKYLRRDLKAREPPSSDEAITSNARNALSEVEDRKNAKRLKMQIDDGQTKRKSPKQEPPRLISYEKVMPKISMEEVTPPPPSSPAPSSPPSSPSPPLSLPSENVSAKTLKRRDRLPKAFATASEQLGYSALLAIACKKIPIPINFFEPLSILQVICEELSQAGPILSKALESKDPLDRMAYVAAFAISGYSGMSTARRRKPFNSLLGETFEYSSADGWRYHSEQVSHHPPISAAHAEGRGWSWWQTFSLTTKKYLARTIENIPELPVRLKLACEDYTWNKVKVVLENIAQTPEKWRLKLDGTMVIQCSNGTSSEIFFDRTKGTAISGIISKNNKTIKLVGFWDKYLQKDGDGKFLFETVPLDYDGDNCYGFSKFACSLNDLATGEAQTLPPTDSRLRPDIRFLEFGEPIKASAAKFALEEQQRTRDKSTYEPVWFHKKEDLMTHNFLWISNGKYWRERENNFRNSNSPELFSTFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3V5</accession>
    <name>A0A158Q3V5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell cycle control protein 50A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7434</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3V5"/>
    <dbReference type="STRING" id="318479.A0A158Q3V5"/>
    <dbReference type="WBParaSite" id="DME_0000327501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000327501-mRNA-1"/>
        <property type="gene ID" value="DME_0000327501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000327501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34786" checksum="138C01B97B72A4B0" modified="2016-06-08" version="1">MVFKAIFYYCFIINEIKDGKNDLKEEFIFLDTRIRQQKLPAWQPILTATTVIPTVFAIGIIFLPIGVALFLGDVYFYYGLNNYYQNHRRYMKSRSDSQLLGDLNSVGDCEPYARMNTSMGEKVIAPCGAIANSMFNDTFELYVGNSLVPWTYVGVVWPVDKERKFKNPPGISLKEAFRNTVKPPNWKKEVWQLDPHNPDNNGFLNTDFIIWMRTAALPNFRKLYRILVRKGVFMDGLPKGNYTLHIANNYPVEVFGGRKSFIISTTSWAGGKNPFLGIAYMVVGSICILLGFTFLLIHFKFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3X0</accession>
    <name>A0A158Q3X0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS233</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3X0"/>
    <dbReference type="STRING" id="318479.A0A158Q3X0"/>
    <dbReference type="WBParaSite" id="DME_0000336701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000336701-mRNA-1"/>
        <property type="gene ID" value="DME_0000336701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4010:FF:000002">
        <property type="entry name" value="Held out wings, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000028">
        <property type="entry name" value="protein quaking isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF147">
        <property type="entry name" value="RNA-BINDING PROTEIN ASD-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="103"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000336701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="45428" checksum="9EDB64917E95BB66" modified="2016-06-08" version="1">MENGHNNSSNCLISNSNSPNIQNDLTNSNHNHGRSVDKAHQYTFEYLAQLLKDKKHFEAFPNVFHHAERLIEEEISKVRVSLFQFEFAKDATLNLPEPEGEVVTMTEKIFVPVKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKAKEEMNRGKPNWEHLSEDLHVLIQCEDTKNRATIKLKRTAAEVKKLLVPSSDDDELKRKQLMELAIINGTYRSGNITPSTAAQAAVVANKNSLAALQARLMPQLPLSASQTNNLRSPTLAGAPIILSPSRGATTAPTAATAAAAALAAQLQAVANQQQQNAAAAALSQQAANGPAAAAAAAVAGIPAHLLQPQALTQTDYSQLYLNSLQYDPTAGTYAIPVSATQTLQTQQQQYAAAAAAAMLGASYIGEYPAMELSNAGQLIVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q424</accession>
    <name>A0A158Q424_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q424"/>
    <dbReference type="WBParaSite" id="DME_0000384501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384501-mRNA-1"/>
        <property type="gene ID" value="DME_0000384501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23042" checksum="18332CC68F263069" modified="2016-06-08" version="1">MVKWSDTLDTASASPDAHDTSSPVVHAISLQSGLKAIPRLVNKMCSQARPYQRGTSEYLWTLQAKRSLSTPCLSIVWISPVGGPSSSLESRGTPGQPTLQPVRLYLSQSPLEKFRTRSYRGAETGNLQGSNHVMVRAKIRIKLTTRKQHPPRSFNYLKLNNLRIFQTELLKHLNNTNINDFSGTANEYWSKLKECLHKSTTSRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4F9</accession>
    <name>A0A158Q4F9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane-bound O-acyltransferase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8656</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4F9"/>
    <dbReference type="STRING" id="318479.A0A158Q4F9"/>
    <dbReference type="WBParaSite" id="DME_0000477301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000477301-mRNA-1"/>
        <property type="gene ID" value="DME_0000477301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000477301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="59335" checksum="23DF75882C5D60F9" modified="2016-06-08" version="1">MPGVHTFYDGSTLLSPIASVVNIEIDKLHLLQFNLVVCQFFAIPLAYFNYKYLSPTKVSRKFRVIFPPIIGLIYCYFCYGNAIKHLLALVFIAYGLMHLSPPKYVHKTVFIFAMGYLIFIHWYRWYILTKYYIDVTGPMMVIVQKITVLAFSIHDGLVKHKEELNEIQKREALLEIPCPSDYLSYIFHFQAVLTGPLCFYTDYMNWIDGTHAMGKNGKLESQWSAVCKKIFQILFFMVLVLIIGDRLNPEILVREDYLQMNRFSWFIMLYIVMVNQRIPYYVVWIFADAIFNISGFGFNGYNEFGEARWDLVSNVNVWKVETALNFKETLDAWNCCTMYWLRRVAYDRAPKGLQTFLTYLVSAVWHGFFIGYYLTFVTAALFTIRRCVRHRFQGTKFSRQLYDVITFIVTKAALAYATFPFSTMHANPGLFVYRRMYFFMHFLALGAIFILPLILSFERKVRKEAETGKNVLFERNSEKKSSGYSLDGKQLAIQLQFIDSNKQKLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4I8</accession>
    <name>A0A158Q4I8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4I8"/>
    <dbReference type="WBParaSite" id="DME_0000495101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495101-mRNA-1"/>
        <property type="gene ID" value="DME_0000495101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61231" checksum="FEF62C6D537D8AF5" modified="2016-06-08" version="1">MLNELINDSGCRLVGSSCGENMVLEIFSKLNGSCVDKCVCANNSVENDTGCVKCDWEEDDSDDADDNNDDSDDNATSYYPTQTYRLGQRIYDKRCIISGQTCGINMLFETINHVKNAYCIQKCVCDRHSKEKNGECIAKQNSECAKNLRKALKKRKDKEIRCIRTGTCKLNKIFYEIQCILQEYSCGPNMQLVVIDKRPSNNVNRWKCVMQCQCVYGYIETSNRCSEIIKGVKERMNCMRGRCSLNEAVQDNGCSLKDQFCGQNMKFALIKQSTYRNHISCIVQCKCEEGFEEENGQCIREYMERSICIREECTLNEIVYDISCSLNGRFCGQNMIFILIKRSKYQHCIVLCKCAEGYKEENGQCIGQHEKTRQHGRRTKNICLENGCKAGMTIHDEGCHLTGEKCGNNMIFTVVSSGVRRRTYSIYCTQRCSCINSDFFERNSGCEKESTTDDLSSTTSLYAITNGMHDFKMYIGKEYHLGEEISDLGCRLRNLECGINKKFITVEEFSAEHDPNIKGCIERCSCILAEAGDCMQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5X2</accession>
    <name>A0A158Q5X2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2470</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5X2"/>
    <dbReference type="STRING" id="318479.A0A158Q5X2"/>
    <dbReference type="WBParaSite" id="DME_0000849501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000849501-mRNA-1"/>
        <property type="gene ID" value="DME_0000849501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="43"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="319"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="558"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="350"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000849501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="656" mass="75402" checksum="19152D7738A2F76B" modified="2016-06-08" version="1">MNQDGYNSQQSDSSEIVGWVAGINEGEKDHQIASYCSVLGKLGYNFVNYPVGGMKRCSWAPNELDALDVLPPPIDLPDLQLDHSLWNLYFIGRISDWIDCDSDQQWLADLSCREIEKELSYAMYMPIRVITINIKHPDSPKLAKIINKWLWTFNITFCIWVIIPIDDTLLAKFDENDRRDVWSIWADFRTLCGNYLMSKLAVGLKMGADLANEFLEPKLVERWKAEPLVTIWIDSSVFIAGLRAGEYALPQCHHQLFLELFTALAQRPMISAGTKNDVYPAMKSRFVKTVKKIIQEKIFRSQQIAVGNDNALFEYMGHREYLDTLQVPLQPLADNLDATTYSVFEEDTIKYNKYREAIGLAISDLVELVKDSRDIIIFLLGAGRGPLMQMIIEAEDLYNAKHRCRRDSLKLQLFAIEKNSSAIVTLKYRNNVQWGERVTVLESDMRNLVDLVRLKTIPQPDLIVSELLGSLADNELSPECLDGVTDILHDTTISIPKFYQSYVAPIQSVRMHQKIMMGFGTKFYDKGFWSRGRSFPELQPDGTYELSRAGVVAFDEIYVLMGFIGYFEAQLYDGCWISTVPQTQTDFLISWFPALIPLRQFIRLEEGSEITFHMERKVDDGGVWYEWFAEYFDPNKSETLRTPVQNENGTSFYMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q605</accession>
    <name>A0A158Q605_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Paxillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2639</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000071">
        <property type="protein sequence ID" value="VDN52666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q605"/>
    <dbReference type="STRING" id="318479.A0A158Q605"/>
    <dbReference type="WBParaSite" id="DME_0000874801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000874801-mRNA-1"/>
        <property type="gene ID" value="DME_0000874801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09339">
        <property type="entry name" value="LIM4_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="110"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="288"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000874801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38917" checksum="95BD95E14091A8B2" modified="2016-06-08" version="1">MPRKLSDNARFVDAVTPALEALLSDLQHTTEILKRAHISNRYNDDKYDIEPVYQEQTRSSHKSVGGISSGHSIDDLSARDSPRDPMQLDSVLGTLQKDMSKHGISTIPKGDCAACGKSIVGQVVIALGKMWHPEHYVCCQCGEELGHRNFFERCGKAYCENDYHDLFSPRCAYCNGPIKNKCVTALGKTFHVEHFVCAECGREFGDAGFYEKNGRAYCKADFFRIFAPKCKGCSNPIKMNFITALGTHWHPECFVCQKCHRPFDSGSFYENGGIPLCEIHYHERRGSLCVDCLKPISGRCVSAMGQKFHPEHFCCSYCRKQLNKGTFKEIDRKPFCHKCYQATHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q637</accession>
    <name>A0A158Q637_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2800</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q637"/>
    <dbReference type="STRING" id="318479.A0A158Q637"/>
    <dbReference type="WBParaSite" id="DME_0000899701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000899701-mRNA-1"/>
        <property type="gene ID" value="DME_0000899701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 9" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000899701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="594" mass="67706" checksum="BA64CCE45A1EBE37" modified="2016-06-08" version="1">MSVDRSIGQQSLPPREQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLVPYVISLVFCGAPLFILETSWGQLLSVGGLGMFKICPIFKGVGIAAAVMAFWLNIYYIVVLSWAMCYLWNSLRFDSNVPWRNCNNEWNTHRCRSEYDPLTCAGNRTIAKYFNVKILTTDHLNEYRKQFFVGMKSNWTICTADDLNVQSPVKEYWNYKVLGISKGLEVPGGLRWDLAIFLLIIWSICYLCIFKGVRWTGKVVYLTASFPYLMLVCLLIRGLTLPGASLGLEFYLKPNFSKLLESKVWIDAVTQVFFSYGLGLGALVALGSYNSYHNNVYKQALTVCFVNSGTSVFAGFVIFSFIGFMAIQQGKSVEEVAQSGPGLLFLAYPSGILQLPYTNIWSILFFTMFCTMEGFFTAIIDEFPHLIRSKKYGREIFVLSICIISYFCGLSTVTEGGFYVFQLFDYYAASGWALLWLLFFECIAISWSVGISQWYDHMKSMIGYYPNPWWKFCWVFATPTVCMGVLIFGLAKYQPLRIDAYNYDYPLWGHVFGWFLSLSSMLCIPGYAIYLWFITEGTPSDVGLSHSVFFIRRIKNIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6D4</accession>
    <name>A0A158Q6D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3408</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000131">
        <property type="protein sequence ID" value="VDN53435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6D4"/>
    <dbReference type="WBParaSite" id="DME_0000980401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000980401-mRNA-1"/>
        <property type="gene ID" value="DME_0000980401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000980401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18953" checksum="ED3C7A7A47E050B2" modified="2016-06-08" version="1">MFIDASRFSKWSKLIKTTILALEFIKRITKNRFKWLSPISDVLCYIIIKEDEVDKARKDGKVRTTAIELPNGKLLKRSVSVLPPLEIDSEIEIETIENYNLDFQRGRKSKYKNQLQCVIEHRREGCLKESESHVIQDSLYARSHMRIPAKRCNIITRVRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P6I3</accession>
    <name>A0A3P7P6I3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P6I3"/>
    <dbReference type="STRING" id="318479.A0A3P7P6I3"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30553" checksum="C0E08B50A241A287" modified="2019-02-13" version="1">MKCFNHLMMVTVGHVDISGAVQGAHEQVVNFFKKSKLDREKLSKIWALSDVNEDGYLDFAEFSIAMHLVVLYVKGSVDIPEKLPISARPPVTAPRNSGSFSSYIFFNMAERLYIFYWCDPDQVFRRSAMKAAQRDRNHYWSDMALRIETAARLDDNRKLFLFLHKATITRETISEMIRDSNGVPVKSIKDRLIRWKEFFEIKLNHEAPVAPDIADTVAGPYVCNCESPTEEEIISVINKLKANKAPRRWSSDRTHQMLSIILHSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PDY7</accession>
    <name>A0A3P7PDY7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PDY7"/>
    <dbReference type="STRING" id="318479.A0A3P7PDY7"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="64"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="209" mass="23518" checksum="038360B3DFED0C02" modified="2019-02-13" version="1">MQLEKQIVSKEQSHLSGDIAGTKANKIPSLETDFDTLNEPVWDTVKRDMNAVGAKFKHVFMPENNDRLIREWDLWGPLFICVFLSLLGNGPHFTEMFTLTFFGSCIVTLNTKLLGGKISFFQSLCVLGYCLLPTGTAAIVCKLIVFSSEQTTTLFALRLLVTVAGFSWATYASMTFFATSQPPRRKALSVYPVFLFYFVISWIIISRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PHA0</accession>
    <name>A0A3P7PHA0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000421">
        <property type="protein sequence ID" value="VDN54245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PHA0"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="196" mass="22581" checksum="2AB4259CD7B4BAD5" modified="2019-02-13" version="1">MRCILQTKQFKDNTIRNKFSTMEYKVSEKCQMPIYVRLAEQLCPRACATCCKTRRFNCRNVKISVGQCKNFTQEMCRTPSLSKIALEFCPHTCGLCDNIDGCENLRGFCHDDSIRNMCQRTCFSRACLQSLTSEFQESLYCTIIFSFRFKMTKNADSQSSGCIDAHVNCTLYRNLCNIGDYGIVMRTQCRRTCGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUY4</accession>
    <name>A0A3P7PUY4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUY4"/>
    <dbReference type="SMR" id="A0A3P7PUY4"/>
    <dbReference type="STRING" id="318479.A0A3P7PUY4"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018128983" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="217" mass="25266" checksum="CF30699D7C7D805C" modified="2019-02-13" version="1">MLCQIIFHQLVDLIKMLILLLLIFFQDCKEQLDNGNKNSGFYRILVPKMEPFDVFCDMTTSGGGWTLIQRRESGEVYFSNRTWIEYEEGFGEIASSFWLGLKKIADSIQNYKLTISPAKAGNLTEYTTGDKFFIMNNGRAFTTIDRDNDKFVGNCAQFRDFGGWWHNDCSYVALNGRYGDSSWKMRGLYWFYSIGQRPVVSYHIKPKRTVMKIRPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PY18</accession>
    <name>A0A3P7PY18_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PY18"/>
    <dbReference type="STRING" id="318479.A0A3P7PY18"/>
    <dbReference type="OrthoDB" id="5828306at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="573" mass="66022" checksum="69AC5E9EC3BED3EE" modified="2019-02-13" version="1">MLESNSYYFFLVSSSESIHKENAVLVKRESHVVFVDENGVVIEDSSHNDLRTVEFNFLDAKNICCGLCGEIVPYELLMNEHLPTHHPEVLGDNHNMDFDETPNVIWLRDKLSNERKHLESGFRSANSYDLPNFSRPNRILRKVSQYRVNPHEMSLDELDIALKKKMVEKMGRRVPVTLVDKQHARCGLCNAVVSLNRKFEVIHLVRHFNAWHPSAHRCQPQAGLGKPLSMQDFAVIDTAVDNGDNLQCIWCGMFMSVEALAMHFSEVHPDDIEVPKCNLCLKELVINARLFEKYNEDFAVTLPDEHHIRCGKFNTTHTSESQFDKAIERRMRRIQSGGDIYTEDAEEDELDLWRKILPNIIDIDISGRRSKPKRQFIMPALRQAAPVGSRFVEPVTDCHWKCKLCKSDILAAVISAGAIRHYRIVHPELLEEMQYELCKARLERVSDGCMEFVHPQLIECLVCNMTYMLHRPYNICRAIRHLKSKHPDMMPEYAGMKEFEKVKLLAVLHYIFLFVQALEGADGERVYVLMAEGEEIDPETANQLAESIGHIMVEENATEKQAVRKNVFKECCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q806</accession>
    <name>A0A3P7Q806_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS1440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sidekick family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q806"/>
    <dbReference type="STRING" id="318479.A0A3P7Q806"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1587"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="189"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="263"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="371"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="473"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="575"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="672"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="768"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="867"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="971"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1069"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1162"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1267"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1366"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1718"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1718"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN51467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="1754" mass="197625" checksum="15D2A4A2C4F5D517" modified="2019-02-13" version="1">MYNNSIVSIIYAQRRLEIKSAHLLTNSDEAVIKCQIIFDPYGDKYSTTIANLTIIKRPEINRKLLPNKISKEVGESLSLNCQASGVPKPFLQWYFNGDRLGINGSHLHIENLDSINFGLYQCEASNAAGVDLTITWLRKGSVFMQILFVFPFYFNVLSKGFILFQLMNLHQIHRDLIEYGPSNQSILIGSNIIMPCKLSDYFENLIIPKIGDPVHRFVVTDDNNLSIRQVGPDNIGLYTCTASNGINEQSVSGWLNIIEKPSMPQMVVAELMNETVPPRIRVLWKIGFDGNSPIIKHYIEMRSLGPLDLWSDWEVVIDNIPSELCCEASIDNLKPSSIYEFRVVAVNRHGPGKPSLPSNNITMPQQPPAAAPRNVAASARSWSSIMVQWQPPPSEQWNGDILGYIVRYRLANYASLPWIEKNISNDHARNVPLEHLITWREYEIQVAAYNDRGMGVFSKPIYVTTLEGVPTQPPRDVKVRVINSTAISVSFSPPEQQVIPGVNQGYKIEIWKGAVSSTSLFRQIRVLPYENPSEVIGDLEKFGHYNVTVLCFTSPGDGPRSKPVEVITFEDVPGAVRNIRFDEILFNMATIIWDPPLEPNGVITKYTIRYRELSSDEKHLLIAKPSARNITIEGLNASTTYIINIQASTKIGAGPSLKAKFQSGIPPILPGRPSSLVVNGIKARNVTLEFVPGFDGHALINKWIVEAKVGSSSIYIPIFNISSPKSHSIIVQGLRPYTKYRLRLIAENLRGQSLPSEPSQEFQTAEAEPEAIWDHIVVEPLSATSIAITWLPFTSVQWNGIPRGYIIIYQPIDVGITELSSKWVNFSLNLLPYKIYAFKMVAENSFGRSVASEIVNATTYEAVPSGIPNNIEVAVNGAGSITVSWQSLSPHQSNGVIWGYRVRVIPENRFLHSEFTQEKVVEDPSSLHVSFSNLRPFTFYHAFVAAFNIIGYGPENFPACRFQTLEDVPGEPSNVSFSYISENEVRLKWDPPYEPNGAIIHYSVAYWKFSKRNDTTKIQLPHNIYGFSATGLSTNTKYLFNIAAETNVGWGPPNVVAVVTTYERNKAQPPSSNKIAVKWINPSLNSDISPLRFIRFEYQEKNKNWIQFSRLISGAANRTIIKGLKPNTFYRIHMRFHSDFGESDWSTESKWIKTAEDSPSSPPVSLKAIPYESSSILLSWNSPPASDWNADSISYRIIYRQYPSNDEFQQEEVVISEQGNLELQYIIKNLPSFRHYIIKMQSTNTKGSSPLSTPIFAYVGFSIPKQRITNIVAKAISSTSISIHWDKWVNDPYDIIFGFKIRYIPLSIVSDEENFEEMLATVNNSIVITDLRKYTEYQVSLSAFNRAGEGQLSSTRVQTFEDLPGPVSNLTFTDILLDSINVSWLPPKQPNGKLLGYIINYRTYKQKEELRKEVREKTRYNSFLATNLEENVVYFFSVKAETSVGSGEEVIANVTTGSPDSPSKPNIIPRQISVRLEWESGQPGFVRFSLFTEDIDGSISAGNVEHSGKEMVDNSHPYHVIGEWITITNSHNVDRLYEVKYRDLQPASFYVFRVFARNLIGVGYPSPESDQLYVPALLPEEPFFIKWWFIIIVTVIILIVIAIVIVLLYVTGSRFKYEKRNSVDSSQFADGGIVSYELRPPKRKNRKDQPLRPNTNTSWVSDCRDLPVYGGINGADTIGMYGSLTTLGISNNNSNWPYLSDSPRHKMSIGNFTNQNRLSDNFSVNDSNGDKSVNENEEEEPDIGGYFFLILVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q930</accession>
    <name>A0A3P7Q930_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q930"/>
    <dbReference type="STRING" id="318479.A0A3P7Q930"/>
    <dbReference type="OrthoDB" id="5775605at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF18">
        <property type="entry name" value="PAN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="298"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="67462" checksum="284A561A1E40BF17" modified="2019-02-13" version="1">MCYLGHQCNSQYLTTYTRSEGYTSDEEARTVFEGITLSQCADRCKAFSECQSFDYDSSSLLCELKTKSAEPLGSSKLLYTNRATTAFFQKLCLTTSFRCPSPFLFERFPQHILVGNAFEVIVNISLTECLSFCLKKNLVFYLRSVMFFYQTHECILNHDSRIISPHLFSNETTGKIVDYFDNICFDGFVQKNAIDGEKFPCKVFAFSDKSMKCHLTSESSSLLLATTNISRLNQAENEFSFYEKICLEDNFYYTSTKVNQIENDRWRIGKNAKIMCQWRKGIRIFGITVCPFTGIESECGLEKISISSHFPKSTSGAIFIKDHFDTCRLEFYQETVAKLEITMPTLRLNNPPCPGREIAPFVWSFVVVVQVNNLGIPELITTNDRVFNISCDFSRIFFENDQLRIKEFSGNIAHDQIRLAILRNGKPVSTVLMGEELEMRWTMLGDKKEHVGFFINNCTAERLDGLSPHPTLLTLIANGCIMEKVKKTLMPYPLIKTDDGYSTVMRIFRFDGSRRVRIRCSIDICAHQCSPVDFFIFLERGERLEQKAITGTLTIVDAEEDKRQLIQQITKKRLLKLRNTNRKITFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QH33</accession>
    <name>A0A3P7QH33_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase A2-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QH33"/>
    <dbReference type="STRING" id="318479.A0A3P7QH33"/>
    <dbReference type="OrthoDB" id="5839847at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018253518" description="Phospholipase A2-like central domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="2">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="55" mass="5888" checksum="2F66F607FA77A2FD" modified="2019-02-13" version="1">MIQFIFLGVLAASNSLINLDLMSYCQLGYTALSYNLYGCYCGIGGSGKPIDGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SKR5</accession>
    <name>A0A3P7SKR5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Guanine nucleotide-binding protein G(I) subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SKR5"/>
    <dbReference type="STRING" id="318479.A0A3P7SKR5"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002487">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="141"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38479" checksum="38A6A9E10539DF30" modified="2019-02-13" version="1">MKADGERASREVKLLLLGAGESGKSTIVKQMKIIHETGYSDEERKAYRPVVYSNTIQSMMAIIRAMGEDARQFFLLAQSCDEGELPPELAVCMKRLWADSGVQECFMRSREYQLNDSAPYYLNYLDRISQPGYVPTQDDVLRTRVKTTGIVETHFTYKDLMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSEYDMRLAEDDEMTFFKILLLFQIFFNRMVESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIRKSPLTLCFPEYSGTNTYEEAAAYIQLQFENLNKRKDGQKEIYSHFTCATDTNNIRFVFDAVTDIIIKENLRQCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0S2</accession>
    <name>A0A0N4U0S2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4522</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0S2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0S2"/>
    <dbReference type="WBParaSite" id="DME_0000016201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000016201-mRNA-1"/>
        <property type="gene ID" value="DME_0000016201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF240">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000016201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44554" checksum="59CBD7CCFBDF7453" modified="2015-12-09" version="1">MRHNEKIFANKSTKLVHNAQQQISQTASGAKAVRHLMSYAENLSHVFEENNSSRAQKTVIKLRRRPPLYIRFTVNAYHKYGLKHIILVLFFLFYIFFGALLFLVIEAPYQNELKYRWEKKIAVNRKLFTDDMMKDFFNNSRFLLYIKGRTTHILTYLEYYEKSLNIRWTEQKLTWNYWNSVLFAGTICTTIGYGHIYPSTNAGRILTMVYSLGGIPLVLLLLQDLGNLLTIFMKYPWFQFKRFLRRALRLITKQSLSEIAFIEMEERNNLRIFDVPIPVAVGLVVIWLWICSSVFCYLDKRWTFLEAFYFFFISLSTIGLGDMVPSSPNTLISMFGLIVFGLSLVSMVLNLLQSKMRSTYEGQKISTEGETIFGPALGIIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2C5</accession>
    <name>A0A0N4U2C5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5178</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2C5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2C5"/>
    <dbReference type="WBParaSite" id="DME_0000081801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000081801-mRNA-1"/>
        <property type="gene ID" value="DME_0000081801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000081801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17205" checksum="E82D7B19E8EE8C4D" modified="2015-12-09" version="1">MIEEKCCECCKRGDVWRLQLRQCEHFVCIACYWIKERGKARIKCPSARCKTRIHENDIDAILDAENHDLNEFMQLEHREWLLHEHRKQIILYAFGGNAVQCPLCKSMYGEYIGCNYVQCVNIRCRQKFCWSCGHPIDSFQHFTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2P0</accession>
    <name>A0A0N4U2P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2P0"/>
    <dbReference type="STRING" id="318479.A0A0N4U2P0"/>
    <dbReference type="WBParaSite" id="DME_0000096001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000096001-mRNA-1"/>
        <property type="gene ID" value="DME_0000096001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775694at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000096001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28833" checksum="2691B118A09EC5E5" modified="2015-12-09" version="1">MTCFESKLINDFGYHEMERRMKFHDKLIKASEICQAERTEFYAPSKSIVDELEEELPPYILPTVHYEKLLMNDPKRIIYVMERMHMMTTTEMKQELKNLHIDFRGKRSQVYERLKNYCLKEYGAIKNAEASHGKLFYNYFVIIDFKCTCGWEKIGNTDHRIFGVTGECKEKNDCDFFIDTFHSYVRPTINPVLTEICIKVTGVTQQIVDNASPFIDVLDEFRTWMRSYKLGRRRTKYAFVTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3D6</accession>
    <name>A0A0N4U3D6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Trimeric intracellular cation channel type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5596</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3D6"/>
    <dbReference type="STRING" id="318479.A0A0N4U3D6"/>
    <dbReference type="WBParaSite" id="DME_0000123601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000123601-mRNA-1"/>
        <property type="gene ID" value="DME_0000123601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000123601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30731" checksum="1C7E42239E10DBD1" modified="2015-12-09" version="1">MSFIDNIKLDQEILLNAANRVQRLKMFPYFAIAHFILMIIGIRDDLGTGASIFSRKHPLSCWASSMLMCFADSIFAHFLLGEPLITPFKRHEEVLVATLVWYLVFYSPFDLIYKISKILPIKVVLCVMKEIFRTYKVAHGVSHAAKLYPNSYIIHVLVGIAKGAGSGILKTLEQLIRGVWIPSYNEILRPSFSTKACFIAAIIFTLDKQTQYISAPHDVVYLGIVGFFIYFKLSAILLNVQDPFAPFENLFCAIFMGGIWDAMSRYNYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3I0</accession>
    <name>A0A0N4U3I0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3I0"/>
    <dbReference type="WBParaSite" id="DME_0000128501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000128501-mRNA-1"/>
        <property type="gene ID" value="DME_0000128501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10615427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000128501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13024" checksum="9346C1F99E82B8EE" modified="2015-12-09" version="1">MDFAAIEMAHQETKSELKKIEENMRMLGIEIPHPIMAEKVSGGVKSVSRIVLDTNVYGIRLPQIPVYRYDIRIVAKTSGGKELELTKQCRDELVYNINNEVFKMLRDVWRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U597</accession>
    <name>A0A0N4U597_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6370</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U597"/>
    <dbReference type="STRING" id="318479.A0A0N4U597"/>
    <dbReference type="WBParaSite" id="DME_0000201001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000201001-mRNA-1"/>
        <property type="gene ID" value="DME_0000201001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000051">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="137"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000201001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51486" checksum="C9860B79F9DC62AF" modified="2015-12-09" version="1">MSNVVDKTLADEEYYHGLLPREDIKMMLKCNGDFIVRITEPVAGQPRAFVISVMVHEEDEERGLSRKNQSKKLLQIKHYIIKCTKNGKYVVEKYYFNSVPEMIRFHLKTQKSLVRSSKVHLTKPIPRQNWELHHQDVELTKKIGEGAFGEVHLGLLRLKNGRKLDVAVKLAKLETLTKEQIKEIMNEARLHRTFDHPNICKCYGVAAGQEPLMIVMELVFQFIISTHTGITIFIYWLQRKKGGIPDILADGGALDSYLQRNKISSDQKMDMCLDAAKGLEYLHARPVLHRDIAARNCLYGDNKVKISDFGLTREGTVYQMDPTKRVPIRWLAPETLRTAIYTQKTDIFSYGILCWEIFADGMEPYPGLTVAEVNIKVIEGYRMALPVHMPYDLKNIILLKCWSDNPNERWTATDIAKNLQRIIRTYQRESTTQISTVSHTSIFFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5N9</accession>
    <name>A0A0N4U5N9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6534</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5N9"/>
    <dbReference type="WBParaSite" id="DME_0000217401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000217401-mRNA-1"/>
        <property type="gene ID" value="DME_0000217401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000217401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5989" checksum="4E7C98F5D24B61CB" modified="2015-12-09" version="1">MMANVLTLNFSIICMTEEIYRNNEHIIEKPPCNSDIFHIKFLICFSIFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U686</accession>
    <name>A0A0N4U686_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6777</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U686"/>
    <dbReference type="STRING" id="318479.A0A0N4U686"/>
    <dbReference type="WBParaSite" id="DME_0000241701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000241701-mRNA-1"/>
        <property type="gene ID" value="DME_0000241701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000241701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12799" checksum="2A2C0EE3B12BB0A2" modified="2015-12-09" version="1">MKILSPIIGFLITFFFPQVNYVISVVILLFLPFKAIPNFLSQFIQCFYSIFSAKNCERMLCCICFSNEKSVLFQPCNHICLCTECATKLITSTAPNCPICRARITSYIDVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U715</accession>
    <name>A0A0N4U715_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RIC3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7111</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U715"/>
    <dbReference type="STRING" id="318479.A0A0N4U715"/>
    <dbReference type="WBParaSite" id="DME_0000275101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000275101-mRNA-1"/>
        <property type="gene ID" value="DME_0000275101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070774at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="10">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000275101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31144" checksum="350FA02D8F2BDD75" modified="2015-12-09" version="1">ESTKINDNDFNDGIFSSWKLGLVVAVIILCFAVLYPNFISPMFSSFFASRSTTQQQKMAPNRPPIYPTMNSPRNRPDIHPGMRNIQNEIPTTSRGNFAWLLPIYTVGVVAFLIYTLVKSRRKKRRRIDYSSHESENSYEDETDDQDIGFHGRKKLKHLQERLKQTEIAMEKILLQLNTLSSESKNIDEKEIIQKIDENSDNDSEKKRITKEVITETNLKDLEKALREFKQLSNKYKKKEERNEKASDNENFTECSEEYNSTDSTDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U778</accession>
    <name>A0A0N4U778_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS56</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U778"/>
    <dbReference type="STRING" id="318479.A0A0N4U778"/>
    <dbReference type="WBParaSite" id="DME_0000282701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000282701-mRNA-1"/>
        <property type="gene ID" value="DME_0000282701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000282701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="47215" checksum="0FF53A07F3FF168E" modified="2015-12-09" version="1">MLFNRRYCNKLLIERANGISLPIIANFLCSNSGKAVQREEMARTPKTVVLLLHHGQPRTLFYAREYLTKSTSDFFKIPKWLAATLINSTWRFTSKTRRAVMNYKEDKALNGIIEKYSISLEKCLNEVIPEFGPISCKYAFLYENPNVNDTITKLIRNGMDRIVFVPLYPNYSCFQTGFLLNAAVKTIRNITVALPESVETNDSHRITPMSGVSFDCSVVDRWGTHPAAICFWLDHLNGKSRFFDSVLFVAPRLYLYNAKEYEREVWSNCQRIMDHLDNKVWCLAWYSGWDQWMVPFSESISSQLQFLQKHGRFHTVVVPINTILPTFDSESILPYLLQKMEVDLAHPVDFSLTFLHAFAELIKNHLLGRPSSAQLSIFCKYCFDKNCVSTREILTNRYSKSMFHTIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U782</accession>
    <name>A0A0N4U782_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS60</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U782"/>
    <dbReference type="STRING" id="318479.A0A0N4U782"/>
    <dbReference type="WBParaSite" id="DME_0000283101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000283101-mRNA-1"/>
        <property type="gene ID" value="DME_0000283101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN50087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000283101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20621" checksum="9DE5D47AB036400E" modified="2015-12-09" version="1">MGIFDLQMFDEVRRMNIRQLYYQGLNFAMIVSSALMIWKGLMVLTGSESPIVVVLSGSMEPAFYRGDLLMLTNDRNDPIRAGDITVFKIEGREIPIVHRVIKVHEKSIEETKFLTKGDNNQVDDRGLYASGQFWLTRKDVVGRAKGFLPYVGMVTILMNDYPKLKYAVLGSLGIFVLLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7J5</accession>
    <name>A0A0N4U7J5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS188</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7J5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7J5"/>
    <dbReference type="WBParaSite" id="DME_0000295901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000295901-mRNA-1"/>
        <property type="gene ID" value="DME_0000295901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="74"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000295901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27738" checksum="76AEF81A37FD3104" modified="2015-12-09" version="1">MLYGEFCILTIMMASWSTNFIHQTINAFVFHMFIFLALFSHLKTMLTDPGAIPKGNATDEYIHRLQSAQNSIIYKCAKCSSIKPERAHHCSICGRCVRRMDHHCPWVNNCVGEANQKYFILFTMYIALLSLHTLYWSICQFLFCVGEEWQGCSMFGPPVTSVLLIFLLFEATLFAIFTLVMFSTQLSSICNDQTAIESFRSLMPGPNGWKNIQMLFGGPFSIKWFSPFIAPYRSKPSFEYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7N8</accession>
    <name>A0A0N4U7N8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Focal_AT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7167</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7N8"/>
    <dbReference type="STRING" id="318479.A0A0N4U7N8"/>
    <dbReference type="WBParaSite" id="DME_0000300801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000300801-mRNA-1"/>
        <property type="gene ID" value="DME_0000300801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847988at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000300801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24265" checksum="A01A1471E3BD7974" modified="2015-12-09" version="1">MEKCSLKDQRKSQDDRSLIDKYSIRRRSIASVPSSEPIADYSPQLPKTSKPEKQIDFDEIQKKLKSMRKCLDDTITALPNQSPKKKIESGDEKVELLKESQMLASACKMMVRNLTSHSEDMQWMSIVHDILERADNVTRNAEKIIQKSNSIFNAHLMLAKADQMLNALSEVLRYAEPIKNKNSSTADDDIKALVIRSTTLTATLSQLIQAVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7R4</accession>
    <name>A0A0N4U7R4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysosomal Pro-X carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7197</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7R4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7R4"/>
    <dbReference type="WBParaSite" id="DME_0000303801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303801-mRNA-1"/>
        <property type="gene ID" value="DME_0000303801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000007">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60597" checksum="99C73BB59E4A3E41" modified="2015-12-09" version="1">MESKNMTSFSGYEGVLTTQRHYDFKEYWFVAEGHNLVSVPPCKLLLFGRIDQWTASRISNVEYEWEEEWFHGMPIDHFAYTDNRTFALRYLINTQNFVANGPIFFYTGNEGNIEAFAQNTGFMWDNAQNFGAAIVFAEHRFYGKTLPFGNKSFTELDNIGYLSSEQALADFIDVVLYLKKQRIPNAEHSPVIAFGGSYGGMLAAWIRIKYPHIIDGAIASSAPVFWFPNTDVPADIYDRIVTRSFVKFGCNAKVVFSSWNSLDQLAKTESGLNYLNALFNIDKKSEMAHQRDVAYLKSFIRDVFETMAMVNYPYPTNFLQPIPGWPVKVACGYFDGATTDKQLAKALYSVVNLFYNYTGQTESFCINPNVCEYPDDVLGGLSWSWQVCTEMVMQMCSSGLPNDFFQENCPFTVQGIAKQCENQFGKIGYSSRLLRPMWATNNYGDHFPTASNIVFSNGELDPWSGGGWSPSHKTSDSSLIGMIIPDAAHHYDLRGEHELDTKAIKRARKIEKKFIAKWIRQARKHQYKHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U845</accession>
    <name>A0A0N4U845_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U845"/>
    <dbReference type="STRING" id="318479.A0A0N4U845"/>
    <dbReference type="WBParaSite" id="DME_0000319101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000319101-mRNA-1"/>
        <property type="gene ID" value="DME_0000319101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF534">
        <property type="entry name" value="TETRASPANIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000319101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26092" checksum="EF3B53A8FBE122FC" modified="2015-12-09" version="1">MPNDCLSKTCKYVFLALNAILCIFGAVICALSLWMRFDITIRQKFVNILSQWDPINYDIAEYDIALYVIAGIAFILFIFALFGYFGAFCEKLCAIRVYFSLILLLLLLEIAGLIYLLIDQEQVKNLFIKIFKEELVDRFYKNSLIRQELDELQSQAHCCGASGCEDYLFAPLSCGCSPHVRVTGCAIKLLNAVSENMPVILSIAGIIIIIQFLALIFSCITCVAIKRKQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8D9</accession>
    <name>A0A0N4U8D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7464</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8D9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8D9"/>
    <dbReference type="WBParaSite" id="DME_0000330501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000330501-mRNA-1"/>
        <property type="gene ID" value="DME_0000330501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF129">
        <property type="entry name" value="CAROTENOID OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042249" evidence="5">
        <location>
            <begin position="28"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000330501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="67852" checksum="4C944DCF420A91FC" modified="2015-12-09" version="1">MILIGKPFIFLIHLSLIFRSLSQSVDGVYRGFPDSWNGDQFKRIKCPSKNIPVFLDGYFLCQFSASYGNLSESPGRKLTHMNDAIGAVGSFQISNGQVYFSAQYYPSRPYKIWEFYNRNMSQTFVPWARFSAYNRTSKEIPENIDSAPFHPNLNFWKIGKRIVAGTEAPQWIGYEFDVRTLSNFKLLNLFEDNRIFKNAHTSIIPLSMSIHERIDSNGILWASFFAVDSKDMKFYQGVFIIEPSGVRKVVGLYNFSEIDIHSCTENDEYNGELSDLPGYVHSITSTENYIVIPITSLLLNPCKLKEPPINEDSEIQNGGIWGMDFYEMAPLRFLIFDKNTGQWSTEKPLEAFPSMFITHQINAFEKEGIIMADMVAYENDDPFIKYFSTDFLTTQIYPKTARLLRFSLDINNNRVMYNYLLSKGTTATDFPQINYEYNEKPYQWAYVLNHPFAADNYIIKINVNDPSGTKNKVFKSHRLVLHEPFFVSKPGARNEDAGILIVRALDLRQNKGVLLIVDAVSMTEIGRANVSINIPFGFHNRFFTMKNSMENLDPKANLKTPKAMWYANRLTATTTQSYRRTNRTASSKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8E3</accession>
    <name>A0A0N4U8E3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7468</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8E3"/>
    <dbReference type="STRING" id="318479.A0A0N4U8E3"/>
    <dbReference type="WBParaSite" id="DME_0000330901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000330901-mRNA-1"/>
        <property type="gene ID" value="DME_0000330901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF477">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000330901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27657" checksum="137F0A705ACE1307" modified="2015-12-09" version="1">MLLGFGSLGIGVWLYIDKNTYSGLTPTSYSAMSAAGLCAAAGITAVIITFVGCIALWIASKPLLLAYVLFVILLFMVQAGVSILTMRYKVDVSRKIHADLLRNIKQDITLNQQYIFHGNQMTWDLIQSAFKCCGVDGPSDWFNSSRWPKSNYVPDSCCDPSKFDISGSMINCGKGIDNASLWFSQGCVNVYSHWLLEHIRIVGFIAIAFIVLEGFVMGSAAKFKKINGAKHRMVLFRLRSSIMDSILVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8P2</accession>
    <name>A0A0N4U8P2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS293</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8P2"/>
    <dbReference type="WBParaSite" id="DME_0000342701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000342701-mRNA-1"/>
        <property type="gene ID" value="DME_0000342701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000342701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9401" checksum="4BE0C0923FCD1D63" modified="2015-12-09" version="1">MPILKIEFFEQRRELESNAIAASIVDGIITTVIEDSIEHKTCQELENCPSASFLTNITTNPNLLKSGRLLEFVPLNELKKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U978</accession>
    <name>A0A0N4U978_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7632</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U978"/>
    <dbReference type="STRING" id="318479.A0A0N4U978"/>
    <dbReference type="WBParaSite" id="DME_0000362701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000362701-mRNA-1"/>
        <property type="gene ID" value="DME_0000362701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000362701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13538" checksum="8C4FFCAB7519ADB0" modified="2015-12-09" version="1">MGHKRNNMVPNGHFHKDWQSRIRTWFNQPARKQRRRMNRLKKALACTPRPAAGLLRPIVRCPTNRYNKKIRLGRGFTLEELKAVGISKKIAPTIGISVDYRRTNKSVESLQVFFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9F2</accession>
    <name>A0A0N4U9F2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9F2"/>
    <dbReference type="WBParaSite" id="DME_0000371001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000371001-mRNA-1"/>
        <property type="gene ID" value="DME_0000371001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5797421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000371001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9297" checksum="598DD805A8E967CE" modified="2015-12-09" version="1">MKLLYLLEQIFKISSVFCLIVASFERFRITRHWTFTGFGVRTRWIILFFILFFAVVFKIFTVSVSFLTTIFYICIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9W3</accession>
    <name>A0A0N4U9W3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TMEM132 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7908</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9W3"/>
    <dbReference type="STRING" id="318479.A0A0N4U9W3"/>
    <dbReference type="WBParaSite" id="DME_0000390301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000390301-mRNA-1"/>
        <property type="gene ID" value="DME_0000390301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10026202at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031437">
        <property type="entry name" value="Ig_TMEM132_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055424">
        <property type="entry name" value="Ig_TMEM132_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026307">
        <property type="entry name" value="TMEM132"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388:SF11">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16070">
        <property type="entry name" value="Ig_TMEM132_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23487">
        <property type="entry name" value="Ig_TMEM132_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein family 132 fourth" evidence="2">
        <location>
            <begin position="378"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 sixth" evidence="3">
        <location>
            <begin position="601"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000390301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="917" mass="103600" checksum="5371632919D24D77" modified="2015-12-09" version="1">MDSGESDVEPVRFLFVDMICYYKRNPITALHLSVVPDVNAFLLFSPNQGTNQSESLIYLQNGCPSSKAQSIIGIESGRRFSLPLRSIEDFECFFTFKIALTSISLDRPYVDIIVVAELNFLSSLRQSFCISVKLNYAKLSTAPTSCIISPFDHLKHSCIIRIQVPFSWFPLQDSQKRIITLWRSVGTDCVEFVASSFRSNIVLLPPPKNLQSFNLDKNQNSHLTIEARSNASFAPNSLSTILVRFKYDYKDIKLTAIQIRLWLEYRLEIISVSTANSSVWKILVESLPLPDYQITFTCQYIGTNYLHEYDGYILMILLRLRGTTEVSDLLTNEYNSNQLWAHWLVNYSFSDNKTVENHAASKRLSINFQILPDAPYIVIPILRDTNVINTAILSGRQTGMSMKILAISDGGYLSDVTTKSHCISSETRVLKTSPTCSSVYVDGSEMRGMRKAKIHVHYEIWSASIELSVWYPKFPMTVWISDSVLNAVKEELFHGVDLKYLFKIRILTDFHIDDEETGERIHLTGDRDTLFDVTVLAMNKVHSSNIAVVALQKSEHRIHAIAQGIGSARSIICNLIFIRSNIPDVEYGSSSILVTEEEVRVKSLAVESIVDIDFLISQVPNKLNTFLVYPSLQKVLTQKYQHAILVCRIHYSDEHWIELSELDPEHYFLDAWSSNDQALGISRQSYSEINLIALQNVDQVSVIVQLKSPAHCADPDAMPIASQDVLIEMRFDHTKQKAIQSDPQSSSTSNSFIAQKVSQWRSGLLISIMCISGAIIVLLYILIVRGKKPLNEGYEKLVLPILTRLSSSGSCGKDEDSQEWVWLSKAQIDELIFRCSKKSSIHAIENSTDSIGTHKSISYRGSEISIFISPQATISINSDSLGRHTKSWHNPKIRMTRNPLADSSSEYNLSRYINGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA56</accession>
    <name>A0A0N4UA56_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS374</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA56"/>
    <dbReference type="WBParaSite" id="DME_0000401001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000401001-mRNA-1"/>
        <property type="gene ID" value="DME_0000401001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000401001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16149" checksum="E54F9E383E7A3CEC" modified="2015-12-09" version="1">MALMKSVVIYIILVNVAAGMLMEVLHPTRTIELKGILYCAYEPITMGNVTIRLYDDYLGLYRKEIATAKPDKNGNFSIFGRNRAFIDLNPILTVEHHCVRNKYEPNCTVTGGYVVPSGYTATVYDIGYVNVNLLNDRYEKICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAD8</accession>
    <name>A0A0N4UAD8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS474</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAD8"/>
    <dbReference type="STRING" id="318479.A0A0N4UAD8"/>
    <dbReference type="WBParaSite" id="DME_0000411001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000411001-mRNA-1"/>
        <property type="gene ID" value="DME_0000411001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5878013at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000411001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="857" mass="97033" checksum="65911AB489C0A58B" modified="2015-12-09" version="1">MGLGTFIDYKTPVMDNDCRFNVKKENDYDDNGTSKHVHITPKSSTSLVDAHSPSTNISQSTETPNIFPNGSYVKTEDFLKSGTELNGSSLASQQGQQNLVHKKEMTLEDHNLLTDFSYYDSVASTSSNNEANINDKSSTDYSGYNKSTVISSQSVTNGNHLINKNHYNLVDNLLTANDSNAQFTSGEFAVEKVPPLSPSSAIVPNFPCRQMKIDLYHPFKDICEPLQDSQQRKISSTISSSDVEHRPTTDDQLCLPSEQTINKALALLQRPSTILPKAEQKSAVHSKSHISSYTSPSKKEVTKRRTMQERLDRLRDCGVLEVDITKLEKANTTQLAMLMRRFKKQMPIRKYLSDELIQHIFEKETCDHFGKTGAEIAGGIGIATLRIISSATSLALNDPNDSEATEMSTDDDEDEFFLPSTSSVSKSTLASKHPNASMRMSKSLTTFRFHQERVQMGTLDTRLALAIDECSDQIECINSQLTELRNRKQSLCAKSESADVNCARCIPINSHLRRKLIKVSSILWNNASDDAVATSTSAMDRMKAYSNIDHHLHPHFSLPSMIPVERRIELYVKRRSNRPCRYLRKRLDLPPWISSPSDLNNNESKKNIGSTKVDEKRKRKLENLDEDDCVSDMQDEEYLPWKIARRNKYKRQSSPLKRAHQKLIRRSLDQKRHHEQKLHRRARLVAGKIKDFKQQTFTGVDLDDALPGLPQKIDYKEISIPRFCYKPLNISIISVDSPCTHLAHSSTPIEIAKRHLSLELEERKRFQQYRDYMASKVDQSTDSKTSSLQLKQPNKNVPTGSVLIDSREDSTSANLSLRVNLDDSLIAGDYDRLSVVEPYSPRSYSNIVYGDEHMDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBH0</accession>
    <name>A0A0N4UBH0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8431</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBH0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBH0"/>
    <dbReference type="WBParaSite" id="DME_0000454801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000454801-mRNA-1"/>
        <property type="gene ID" value="DME_0000454801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000454801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47950" checksum="C657360BA051F15F" modified="2015-12-09" version="1">MPQNEWLPIESDPSILTKLIRKLGVRNAKIKELYNFDLQQSVYGLIFLYKWRPTGLSLRKNFVYNRKIIFGQQVIQNACVSQALVNLLLNIPSNSGVSLGPVLEDFKQKTSCFDPMSRGLAFGNMDSILEIHNSFAVPDVPEPDIRAPEKDFKNHFIVYMPIGGRIIELDGMNSEAADLGNCMNSGIDWLQNIFPLLDECITKFNDLEIRFELYAVISGETIDYHEQLVQLTKCGKVERNSQEILKLRKLIELEEAELKQLKRQSVLRRYNYTPFIVEFLKLLAKENKFGILIAENSEAKAKMQHETTEDNCGKIIKSELNKKVDLETMCVNSPKETNSAKLNVEENAEPQHKRIKFKMEDSKEKGADELLDETIKQETNESINQEHFDEEISTEQKCDSSEVEQKGNAKISCSTGSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBL1</accession>
    <name>A0A0N4UBL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vesicle transport protein GOT1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8478</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBL1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBL1"/>
    <dbReference type="WBParaSite" id="DME_0000459501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000459501-mRNA-1"/>
        <property type="gene ID" value="DME_0000459501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000459501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14745" checksum="B4CAF83DD0F934B7" modified="2015-12-09" version="1">MFAEIGIGLTLFGITFFSLGIILFLDGALLAIGNLLFICGLVLVIGIQRTIAFFLQWHKAKASSLFFGGIFIVLIGWPLIGIIAEVWGFVLLFGGFLPVALNFLRQIPIIGSFLNMPGIRQILDRFAPESRYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBY0</accession>
    <name>A0A0N4UBY0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8622</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBY0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBY0"/>
    <dbReference type="WBParaSite" id="DME_0000473901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000473901-mRNA-1"/>
        <property type="gene ID" value="DME_0000473901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FRPR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000473901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30750" checksum="028D699CE937DA7A" modified="2015-12-09" version="1">MISSMNCYLCALAISDMTVIITAFFLFFLENIRRRSLIISKFFAILAPITFPLGLTAQSFSVFLTVTAAIDCFILVSASAACKKYFCTVNRSIQVVIGIFLIAAMYNSPHMFEIFVVDCWSLTYSHQSLDTYLTVYYAWLYTAVMAVGPVISLIILNTAIILSIKHGKKTSQDDSDSDIITLVLVVCLFISCNILPLIVNFLELFFGVTNSYLIDLSNLMVVLNSSCNFLIYYAFGSRFRCTLKQYLFHSKKSFENGSTRLNDLFAPQTEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ8</accession>
    <name>A0A0N4UBZ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nas2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8644</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ8"/>
    <dbReference type="WBParaSite" id="DME_0000476101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000476101-mRNA-1"/>
        <property type="gene ID" value="DME_0000476101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000476101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17460" checksum="FC1BAD1619CA2F25" modified="2015-12-09" version="1">MVSKDEIKKLIEKRDKLDQRIAENEEILKANGVDMKTDLVDEEGYPIASVDIMAVRQARNIIICAMNDRNQLTSDIENALHELHAQGLKEGDLVIQFDSLHADNFNDIKQLKTKIIRITVTRQYAPHKLELIPSLWSGPGFLGCSVLPLNSAQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCM3</accession>
    <name>A0A0N4UCM3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8822</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCM3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCM3"/>
    <dbReference type="WBParaSite" id="DME_0000502301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000502301-mRNA-1"/>
        <property type="gene ID" value="DME_0000502301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000502301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31950" checksum="B21C6BC920E15269" modified="2015-12-09" version="1">MIRDRSSEFRRKVVANAEDVLSDRKVNGTPEPILPSNLFFVEVDEVRKLIINLANDVAELEVEQSNILAKTMIEESQKADLEKDKKNIKYCHAEDIDLRMRKHHIEVLVKKLYDVLENFAAAQEDYRKRATKRIKRQLELAGEQLTDTEINELFDSNITQIYNRDLTTVAMRSVMDDASSRQKEILKLEESISELNDLYNDMAILLQQQGELVENIDRNVEEATYYLHEGNQQARIAISYKKGAIRKKIFIIIVITVILVIIIIALLIYFLIRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCZ9</accession>
    <name>A0A0N4UCZ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ-loop repeat-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8969</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCZ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UCZ9"/>
    <dbReference type="WBParaSite" id="DME_0000517001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000517001-mRNA-1"/>
        <property type="gene ID" value="DME_0000517001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000517001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10244" checksum="DFFCC526A655CD03" modified="2015-12-09" version="1">MVSLLVEACLGIPQLLRNYQRHATTGMSVRMVLMWLIGDCAKTVYFIVRSSPVQFWVCAILQITIDILILAQVHFYGKGAASLPYASAQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD36</accession>
    <name>A0A0N4UD36_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD36"/>
    <dbReference type="WBParaSite" id="DME_0000521601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000521601-mRNA-1"/>
        <property type="gene ID" value="DME_0000521601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824539at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000521601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11771" checksum="0C88FABB1B09728F" modified="2015-12-09" version="1">MASEWSNLITNWRSRIQTVNDREQILEAFSMAIQDVLSSRSRQNSVIDILSHFIWKKASINAVTLFIKNYNNSRDGFTELSAINTKFSYDQNNQNLNNRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD79</accession>
    <name>A0A0N4UD79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9067</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD79"/>
    <dbReference type="WBParaSite" id="DME_0000526801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000526801-mRNA-1"/>
        <property type="gene ID" value="DME_0000526801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="57"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000526801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21592" checksum="9E9CC28C2E370DCB" modified="2015-12-09" version="1">MFFELCRVTSQFDSKEVRQVRLSHVLEKPQLYYDEQLSEWVYPVDEALEKQLEQVAYFCKSINRNRALRALLTQPDGSFILRISESKNRCLALSVRVPFNFNSSGISHYLIIRNERGFKIKGSNKSFPSIPMLITHHSVMREQLPCRLFFVQWDRLWDYEDNNNYDYPPCEDYECRMRADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDG3</accession>
    <name>A0A0N4UDG3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trigger_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9174</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDG3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDG3"/>
    <dbReference type="WBParaSite" id="DME_0000537501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000537501-mRNA-1"/>
        <property type="gene ID" value="DME_0000537501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000537501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17523" checksum="4D0EDE8635EE4611" modified="2015-12-09" version="1">MEHFSIEERRSFMKEEMEVFVSKLDTRTSEQFNSALQKAIIESLLDGTVFPIVESLADLQNMTERQLFANRQQQLIELQSVPDLDTRMRLIDMDIVYELDKITTQQQDTLARAGVPGFRITKNCREIILQMAIIRFIVGVQKKIQNLSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDT9</accession>
    <name>A0A0N4UDT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9255</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDT9"/>
    <dbReference type="STRING" id="318479.A0A0N4UDT9"/>
    <dbReference type="WBParaSite" id="DME_0000551401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000551401-mRNA-1"/>
        <property type="gene ID" value="DME_0000551401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000130">
        <property type="entry name" value="neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="WH1" evidence="11">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="10">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="12">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="12">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000551401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="65007" checksum="7ED1E61D93ED0FEE" modified="2015-12-09" version="1">MATSLCQPIMTKVNGTSSNSAGRPRKRERPPNKGAHLLSSTENAVLFSLLGRDSVSLAAGVVQLLRTDSRNPRAWMKAHIGVISLVKDFEKRAYFLRLYDISKKQFLWQQMLYKNFRATATNCPNLLTFEGDDCVFGLNFSNLDEADNFKYHLNKRYEQEQKSRKNTNDIFLHLIAFLFFSFEYILIIWSSSGVTAERAANSGASHGTSMKTGVMSSITSPTLSTTNKVGITSIGAVPSVGGQLANLVSSSKKKKKNNKERKIRKEDISNPTNFQHKAHVGWDQDGGFSQKTYDGDPMDDSVRDLLRAAGENPDMMTKEDIDFSRKFITGYQKLPQPFIPQATPISQRYPLASSPSVSATNTAPPPPPPPPPPIRRDTTTTSSRPFQRPPQSVTRAPVRPLPQLPSLSSVANNQIYRPNDIPPPPPPPPPVTSQIEVTSYIPPATPSGPPPPPPPPPPPSCITQQSYIPPPPPPPPPAINEQPSLAVTSDRANLLNEIQAGITLKHVDKNLRHRDDSANPHENVMAEIKQGANLRHVDQTVQDQRKLITSAPDGIAGALARALEERRKNIQQSDESDEDEPNSGSEWETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDX6</accession>
    <name>A0A0N4UDX6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9294</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDX6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDX6"/>
    <dbReference type="WBParaSite" id="DME_0000555301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000555301-mRNA-1"/>
        <property type="gene ID" value="DME_0000555301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000555301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16955" checksum="37B2AB9228880E65" modified="2015-12-09" version="1">MAKNMSNTDYRKLDVDAFDPERYHDLDDGEESAGPDERLVSQLLQTSKLNEALKAALMNPPLKTKNQIVKNRATALVTRVLTSFKTADMESTVQNLTNDEVDLLMKYVYKAMDILADNSTCQYLLAWHAQLLARGGYGSIVRVLCDRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDY4</accession>
    <name>A0A0N4UDY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9303</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDY4"/>
    <dbReference type="STRING" id="318479.A0A0N4UDY4"/>
    <dbReference type="WBParaSite" id="DME_0000556201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556201-mRNA-1"/>
        <property type="gene ID" value="DME_0000556201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34262" checksum="1C13D4A094370C78" modified="2015-12-09" version="1">MHYDFILFGFFNLSNSFIYRFIYLFFFFFFSYLLIIFISFLVSISNNLSLNFNISIPVLIIFRSGSLIAQLIMGRYLRNNFYSQRQIVSVLLLTVGIIIFTLADIKEHRKISIVRTSIFLLPSSLIASPGIALLTFGLFASAYLGICQENLYHKYGKHHEELMLFVHLLSLPAFIFFYEDIMNGISRLNYSLPLHMFEFPVPRLWISLVALCISQWICVKNVYKLTSVTSPLNVTIVVTMRKFISLTLSILIFKNAFNMIHLVGALLVFIGSILYTDDISPFLFKIKEKFKKIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE84</accession>
    <name>A0A0N4UE84_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 13 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS718</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE84"/>
    <dbReference type="STRING" id="318479.A0A0N4UE84"/>
    <dbReference type="WBParaSite" id="DME_0000567301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000567301-mRNA-1"/>
        <property type="gene ID" value="DME_0000567301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="347"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000567301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55946" checksum="3FBCEDDF0D9BBD92" modified="2015-12-09" version="1">MLAAYIVLLMGLLWMTEVIPLAVTAFLPVIFFPIFGILPAKRVSIFYLTFAFIINSLKDSNFVFVGSIIMAVAVEESRLHERIALRVLTFTGSNPRRRPSKAYIHMLLLGFQLTTASLSLWISNTAATAMIVPIAMAVFKELRIHNEFKLRKIENIPLHWELVKKETIFDFQNIPRREKNIYKTFFNIFHAILLSICYSATIGGTGTLIGTGPNIVLNGFLEKIYSSETPITFATWMLFTIPQIICIQLFCWLWLQYIFIPIKFDERLVLILFSCLVFLWLFREPKVVPGWSSLFSHHCISDGTVAMLMAFLLFIVPSENPLKPPRNGQQYSTLMTWNKMKEKFSWSTIVEKSGLSDVLGSQLGSFTSLPRWLFISASSTLITVITEFSSNIATASIFIPLVNSIAKQNRTNPLFYILPTTMACSFAFILPAATPPNAIVFSSKMVKVVDMVKAGIVMNAFAMAVAVICTYTYASILFDLQSYPDWAEYNHTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES4</accession>
    <name>A0A0N4UES4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES4"/>
    <dbReference type="WBParaSite" id="DME_0000589601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589601-mRNA-1"/>
        <property type="gene ID" value="DME_0000589601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38255" checksum="3089C63BE1485B90" modified="2015-12-09" version="1">MFDFSVLQPKSHDDKKIEYLSDDTRMAHVRDSNFVGENSETELEMQKWTTSQSNGSRQNLLGTSSTFSDDMSSHRESDCTTGESGNYDCGLQAITHAPCSFDFSNEYSTPPHEQYNEKHDSDFARENDYKFYAGNNEKRYRIEGSENGIHVDGVEIDDTWQNEGEEPRWTDRKQRMWTTVFNEEEEKLEDNDDYSSETTDNRSSVVGNVQSRIDLNSYQSARLDDEKSQNDVHEPQFLQLNNVISSIHRTQSSSDALDKPIVPDEVPDPFFHHGNSNGDEMQRTRPEIKITDHDKDKEHRGDDDSDVETSPSSDEDDYPDQAISIIIIHKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF22</accession>
    <name>A0A0N4UF22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF22"/>
    <dbReference type="WBParaSite" id="DME_0000601101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000601101-mRNA-1"/>
        <property type="gene ID" value="DME_0000601101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831930at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000601101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9480" checksum="5D38BE4D692767AC" modified="2015-12-09" version="1">MRMYLHSRGDYKSTRPYSYTRIYGNTSLYTPPMLAPEARLLTTRRGYSGYTFVGGEHSYDVSSRPYSLNNYHFWRSHIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFA4</accession>
    <name>A0A0N4UFA4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1043</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFA4"/>
    <dbReference type="WBParaSite" id="DME_0000610401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000610401-mRNA-1"/>
        <property type="gene ID" value="DME_0000610401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000610401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13113" checksum="56F0E7BD8C393F33" modified="2015-12-09" version="1">MKQNKRKSRKRIVIKNSQRGAEKPEKSAENSLAEQSTTKPCGPNVHEQPSAVGYEMKMDKKKIELRDFQKCQLFQDGRGDVNAFGQTLNDLLSHFMDEQKIDNVRKRIDEMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFF1</accession>
    <name>A0A0N4UFF1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9455</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFF1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFF1"/>
    <dbReference type="WBParaSite" id="DME_0000615901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000615901-mRNA-1"/>
        <property type="gene ID" value="DME_0000615901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830034at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF29">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000615901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7309" checksum="88D8827DDD2936D9" modified="2015-12-09" version="1">MNQIIIEPTSLKNTCQICFMPADGIHFNVVSCRACAAFFRRTIAQNLDYKCRTGFSACDINKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFQ4</accession>
    <name>A0A0N4UFQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAZy families GT2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1179</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFQ4"/>
    <dbReference type="WBParaSite" id="DME_0000628201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000628201-mRNA-1"/>
        <property type="gene ID" value="DME_0000628201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7480412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000628201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7582" checksum="1EBF6AB99FEE167A" modified="2015-12-09" version="1">MSGLRPFLYNIQLYGRLDNGHRLSALTRSVQSRADPEYADDAILFVDSYNEMMLNNVSNAARENWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG56</accession>
    <name>A0A0N4UG56_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9566</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC30/dfy-1/fleer family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG56"/>
    <dbReference type="STRING" id="318479.A0A0N4UG56"/>
    <dbReference type="WBParaSite" id="DME_0000645501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000645501-mRNA-1"/>
        <property type="gene ID" value="DME_0000645501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249577at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042280" description="Tetratricopeptide repeat protein 30" evidence="4">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000645501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18923" checksum="4601F7512DE8BBC8" modified="2015-12-09" version="1">MILDLLFACNMAVVSYFQAEELMKKVENDEEIQYIDEKKKSFHLCIINLVIGTLYCSKGNYEFGISRVIKALEPFDEKLGTDTWYYSKRCLVSAIENLSKHIISIRDSIIDDCLHFLEQCEIFGKQIPTVINGPLMDPRLENAKSTVTYEARLLRALLLEVVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGJ8</accession>
    <name>A0A0N4UGJ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ima1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1267</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM201 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGJ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGJ8"/>
    <dbReference type="WBParaSite" id="DME_0000662301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000662301-mRNA-1"/>
        <property type="gene ID" value="DME_0000662301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005521">
        <property type="term" value="F:lamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040041">
        <property type="entry name" value="TMEM201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28646">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28646:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000662301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35153" checksum="14E9FB5E112423E9" modified="2015-12-09" version="1">MEVYLTYGIIFFISFVLLFCAHFFKVEVNCWFCNRNFPVEYSIRKSFVCPFCDQYNGFTNSGDYDKIIREQRYEYLNPPSSRKAEHLNRLKQKLEPTDNGICNRCNATQNLIQTEINSFEPKNENNYANELNEFKSRLHRAYPLCRECEVYLMVLIFLDYSEESKDVLLSRLGFSSILTVLSFAVTFLPRKLLHRKRQNSILKSAFSIASTPQSQCSTISTSSAYETASNNKKGMSTCSIYNDNSKSIRDSTPRELGFLLSGLRLERSDMDENSVLNRKSRGFFTNNYFSIFIKSLFKINFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGM5</accession>
    <name>A0A0N4UGM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9677</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGM5"/>
    <dbReference type="WBParaSite" id="DME_0000665101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000665101-mRNA-1"/>
        <property type="gene ID" value="DME_0000665101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861060at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000665101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12621" checksum="ADA74928187D7F25" modified="2015-12-09" version="1">MWKRDMNSPNDHKLTWLEGSHDQEGGAFMVRLDHCTLGQVDPCGIPESGFANSVIFALGDSVRASLIIGTGVCQGCPKFQYTGNSDAIDCFPMCVCVCAIHIASIPLAILITIKVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH02</accession>
    <name>A0A0N4UH02_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1408</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH02"/>
    <dbReference type="WBParaSite" id="DME_0000679401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000679401-mRNA-1"/>
        <property type="gene ID" value="DME_0000679401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804602at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000679401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="44085" checksum="A89DDBA7DFAB80EA" modified="2015-12-09" version="1">MFKNIFRPRKFNKENEELFLEHTKSNTPISQNLREEKDEHLKDENYSNERVSPADLCRISAANTFSPYDIVTRGRYQRNAYSCYEDSARRDSYHERHSHINRFLTANAVQIPKRFEQTISRGSYLSPEYENYATSTRRLSRDLDDSEAESFNSERIIKELRAELRASNDRKNYYKDLYKRERRDRIKDRELRDMIEKRLMEDLRTREIECNNYILHIKSLEQELQLHAGYSRYLRDNEVFRVPHFCTPSTSNTTSTLAGAGEALSSTSELFHSNKNRIFMQSTNDLPDETKVFRQLDEIISIECPRDVSHESSSEHPENLEVPNETMLEDDKQSDHGYGTTSECASEVRNIRRVHSDSDIVVSPKRFMCSTSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHG7</accession>
    <name>A0A0N4UHG7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium and integrin binding family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9796</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHG7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHG7"/>
    <dbReference type="WBParaSite" id="DME_0000699701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000699701-mRNA-1"/>
        <property type="gene ID" value="DME_0000699701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF6">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000699701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23597" checksum="313E8C7D2F68F1B2" modified="2015-12-09" version="1">MGNTGSSLTDLNLFSKGGVFTREQLDEYQDCTFFTRKDILRLYKRFYTLNPVKVPTNMQGTRPSIITLCFEEIEKMPELKENPFRRRICQVFSDDGCGNLTFDDFLDMFSVFSEMAPLQLKLKYAFRIYDFDGDEQIGHDDLCKVIRCLTRDELTDEEVEFIIERVIEEADLDGDDQISYAEFEHVVSRSPDFIRTFHIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHK6</accession>
    <name>A0A0N4UHK6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1593</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHK6"/>
    <dbReference type="WBParaSite" id="DME_0000704101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000704101-mRNA-1"/>
        <property type="gene ID" value="DME_0000704101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5777712at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF6">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000704101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47043" checksum="CB48EF91D304A8F5" modified="2015-12-09" version="1">MFVLEIDGDADLTIHNISILPSDQCATDDQRAAKCCCGDGFFFDFPTKKCKVLANAGFMFGTLNDSWSHIVIYGFIYPMIVVTLIAPLCAVLLGMGKREKREGEQRFPNPLYQMIWLLLFCGWISLFSPLPFSVWYYIVGDGTRSFNHSITMCHIFQTTMEAVPHAVDTMMTLFSILLAGGRFLTQYHRSRLKLRTIERFAKAIWTIIFICMTLGILRFFEHGADLYQFCLDTEPGPYWASRCMVVDGPLLTIINRRFWKIALPLTDFCIQFLFPGFLLVVLHIGFIKEPIIDFDDKHNRFGRTPRDQTRILITAVTIAFLIVQVPTAVYTTMTLTVNHFNANVLSKIAVIFAHLQPFLSVATIVANNGAMLTAYYIIVKDNDIDVGDSHATVSSTDELDELLRCDKDFRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI23</accession>
    <name>A0A0N4UI23_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9904</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI23"/>
    <dbReference type="STRING" id="318479.A0A0N4UI23"/>
    <dbReference type="WBParaSite" id="DME_0000723601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000723601-mRNA-1"/>
        <property type="gene ID" value="DME_0000723601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000723601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17649" checksum="7E9ECD97330E0ADA" modified="2015-12-09" version="1">MDRLSLEEKSRPRPTPTLLIIHKFDRLIILVLLGNTNKAGESSQRMDGEYSTANCAESKSNVSKWLGKKLRIEMSDGRIVEGEFMCTDSVPNIILSGTKERWKGESEIRTIGLTMISGRHICSIHLLTEYDDNQVDSVDTDPSSDTDPHCLETVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIJ9</accession>
    <name>A0A0N4UIJ9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10001</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UIJ9"/>
    <dbReference type="WBParaSite" id="DME_0000743201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000743201-mRNA-1"/>
        <property type="gene ID" value="DME_0000743201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000743201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27994" checksum="40ABB6D79053F4A3" modified="2016-06-08" version="2">MFRNQYDSDVTVWSPQGKLHQVDYAVEAMKQGSATVGIKSNTHAVLVALKRAANELCSHQKKIYEIDTHAGVSIAGLLSDGRILARYLRTECAAWRWDYKEPVPIQILNDRIQLKLQANTQHYGRRPFGVGFIIAGYDEKGAHIVKTDPSAEVVETYASSIGARSQSARTYLEKNMDEFYTASLDRLIEMALFALRDTLPTDDVLSQKNTTIAVVGKNTPFKVMDDEDVKPYLDRIDRIPRAGIQAEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIT1</accession>
    <name>A0A0N4UIT1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1795</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIT1"/>
    <dbReference type="STRING" id="318479.A0A0N4UIT1"/>
    <dbReference type="WBParaSite" id="DME_0000752801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000752801-mRNA-1"/>
        <property type="gene ID" value="DME_0000752801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="253"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="357"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="469"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000752801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69494" checksum="4EE34F45CFA0DE87" modified="2015-12-09" version="1">MEPIPEEDHDSVDVMHSDNVVKHERKTRLTEVYTSEQVDTLVSTVPESAVPDSWKLANDEINLDPSMSSTYITEAVAGPTSSRGSTYSYTYESHFDETPAEEIKHYDQQMTNGDVERRSMQTQKVVEVSLGMLFSATCQFYADLGSNHNMITRVTKVTTTRSVRQMPINRFDNEIYFNAEGSPVPANEASTSFYENVNYKESDYLDSGMNLPDNDQLSSKMHKNLYDIPPPAPSSHYGSRVTSSLLHHDKLNCPGMPHVHRLDSGEVEISWAPPEKVGLDEPMMGYQVEVRQIGTLKWRIVEERLFKETRCRISGLDPMMEYEFRVQAVDSAGYCQPSLPSAVGKLKSSINKWEGAAPSKPYITFMDTDRVLLEWDPAVTDPNCAPIAGYEVEYRATGSTDWMQSNNFLITDCNYEVQNLRPYGEYEFRVVARNVDGLSQPGLSSGIIRIRPTVPSRMTSSQSRVDIIPPGQPQVIELDVDWVKLHWAEAMCNDIPPASYIVEFREIGDPLWYTANATVCDTTYLVERLRPNSTFEFRVIARMRDGSVSKPSIVSDVIQLRPSMRLGLLHSAPSKPQPPEYVDFEGNDRVTLCWYPAVSSLPILVCFGILLYDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJQ7</accession>
    <name>A0A0N4UJQ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000042">
        <property type="protein sequence ID" value="VDN52057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJQ7"/>
    <dbReference type="WBParaSite" id="DME_0000790501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000790501-mRNA-1"/>
        <property type="gene ID" value="DME_0000790501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000790501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32263" checksum="27352164FBF46AD8" modified="2015-12-09" version="1">MAPKKVAVYGAVSNNDVSCLNKTIEDLTTKKSTDDESATADRLLAENIVVVAGFKTEFIKEVHSHGRKGTGRPRVLKIRLDKHMAMSVLRNKDVRSIVPPGSFLRKDLTKRELLLDKQLRKECYTRNQSFNLKKLILTDNPNNISCINETWLNDSIDNRELNFDGFIVSRKDRTINSSNIRGGELIMLIPDYYKFITFDDYVCSPFESLIIKIYLKYNRNISLLNLYRPPGYGSKFTRDLYNLLLKSTLIGTDYIIVGDLNMPNIDWENSCLKSSNKFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKI8</accession>
    <name>A0A0N4UKI8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10318</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001211">
        <property type="protein sequence ID" value="VDN60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKI8"/>
    <dbReference type="STRING" id="318479.A0A0N4UKI8"/>
    <dbReference type="WBParaSite" id="DME_0000825701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000825701-mRNA-1"/>
        <property type="gene ID" value="DME_0000825701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000825701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27699" checksum="9E6FF6DCC550DCE2" modified="2016-06-08" version="2">MLHDANDNFGFGDMWYHGFRNNCIVEQNNMLRDSSYIRSAIFDNTRSSFMDNMALFGDYDHSIFTSLNQNISNQNISDNLSNHHYHHNNQFNSNLPQEHILSNFSAMNACMQACNDASMRNTLAFSRTNNISSSTTASHNDLPVVTTSSARYNIFPSSASPRPSPMQSKELLQAYASSYLAPESTNELNTREKCSNISSFTLNSNKWNNGIQTCQVCLAAASNGLHFGAKTCAACAAFFRFLFVLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL00</accession>
    <name>A0A0N4UL00_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2420</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000060">
        <property type="protein sequence ID" value="VDN52447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL00"/>
    <dbReference type="STRING" id="318479.A0A0N4UL00"/>
    <dbReference type="WBParaSite" id="DME_0000844501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000844501-mRNA-1"/>
        <property type="gene ID" value="DME_0000844501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="691"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000844501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="848" mass="95660" checksum="A8DBC1E8E7F7EFB2" modified="2016-06-08" version="2">MFDTIVDQVSPSVEQLPSSSSLQVSSVSQPFMGYVGYIERTYDEKNDEDQACHSGRGSQASYLAPVSTSIYTANVSEAVMINEKSKTVSRKISENSSISVPLITQMPLEMSVEEILDPSKKEIIQKKYNMFSKTSREKQLQQYVKTVAKIDTRIEELKKKLEIECREKNKMVNKYKKIASSSNGSEYIPTKKSVLQQPCTSGQSVGPLKYLGGYTPTPIALLKSGRSVLEKNKDEDVNCVKKTKKEKKDLQKLANKKSVFIEDLFDDEKPPEKKKKPSLASANCKEHFNSDELKLKNQNTSASQSRSSTQIDNKKVLTPNISQQLAMRYWKVAKDKKAMANVNENKSKNLSQFTKIETLAGTFDKGEKRKAHLTTAATSMKLIPLDPFATGKVPFTVRVRYLNLFYNEFVKVCKKPEEAILMAKAKEKAIKDQASTKSGYICSAVNNLNKLRVSSKNGSSPNGFKTISHEATLVGRHLGSFSVVKRDYRPGNKQITEKEFYASLNEKYVISMAELYDNGFPLWKDADKKIIDTDRKVASGYDNKAKIYTDENDLKRICCRCGAEFFLTKNGEIANPQQCIYHWAKAFKQKVSYHSSSDYIKKNFSLSQVALFFIDTCIDHSTLLFYFLQLYNLFLVKGSLEARYMCCSSDLMVQGCCIADSHVTSTALLTDLDTFVESPAPSGPNDPRSSRVYALDCEMVYTGHGLSLSRITIVDIKDDLVLDILVKPEYRVMDYNSRFSGLTKDLLDKAEYDFKQARARFFEFVNSETILIGHSLESDFKAMRIVHHKVVDTSVVFPHKKGPPFKRALKNIASDVLQLIIQEDVGGHDSKEDASACMRLMLHKIRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULC5</accession>
    <name>A0A0N4ULC5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001217">
        <property type="protein sequence ID" value="VDN60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULC5"/>
    <dbReference type="WBParaSite" id="DME_0000859301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000859301-mRNA-1"/>
        <property type="gene ID" value="DME_0000859301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000859301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8310" checksum="12F94F96E26D2C69" modified="2015-12-09" version="1">MDRSADEFVMERSASESIVDKSAGESAVDKSAAKCAATSNIAKFNQRMIINKLLGDWFNDWFLTDEGFAIVLSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULG4</accession>
    <name>A0A0N4ULG4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2553</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULG4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULG4"/>
    <dbReference type="WBParaSite" id="DME_0000863801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000863801-mRNA-1"/>
        <property type="gene ID" value="DME_0000863801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3565419at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000450">
        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000480">
        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF19">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000863801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25144" checksum="E8D8AFEA9E1F2CEC" modified="2015-12-09" version="1">MPDEISNNGYQCERCGKMFTYAYYREKHLKYTRCIDKELEKKKIKFFLKLSAFHKSFEKRDRLRIHVLHVHENHRPHACSICGKSFSQSSSLNKHLRVHSGERPYKCEYCDKSFTASSILRTHIRQHSGEKPFRVNFFISTGDQASEKFINAFQCSLCGKSFASHAAHDSHVRRTHASQTLFQFKCEFCDKTFQHKRHLNFHQQSVHHLLCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULH0</accession>
    <name>A0A0N4ULH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nup54 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2559</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULH0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULH0"/>
    <dbReference type="WBParaSite" id="DME_0000864401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000864401-mRNA-1"/>
        <property type="gene ID" value="DME_0000864401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4238at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="603"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="2">
        <location>
            <begin position="751"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000864401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114518" checksum="AD44632C7751AB07" modified="2015-12-09" version="1">MMQKIDNSLAIGQSTCFRSLPSFRKSPFLNVDEEEKIVQTARNICKGIINNRKELTKLQQDVIDLEARFVYLSAYKRDCDKSLFGQKLNGDKLLASQHPNYIESSFGKIAQVLTARNKSVSPSKEEKKSSNLHSDILSKLEARLFEATLSSFASHKPIYSIHGATMITPHKEISTAYSDITSQETNFAADSTVLPPALSAKETSKTITIKETQQKIKNEGVKSADSLIKQETPENIDITQVSVPISQISATAEMMKSSKSASQNIQISAQFDECSTKSSFSPCPNKLVDTIIISKDMSNSKKAISISNSDVTVSSLPSNILAHQAEESNENTTSTSVQTVSKDVISPVPNASLFGVTKNIEISATMPTKPLASNAPVTFSFSLPSEKTATVVSTYSTNTSLSADATTNDKGVKKNSTDASKNVFGVGLNLNSSSFASSGQSNSVFDAAKLTIFDGGQSTGSIYGENQSPGSTFRQSSFFGGTALTNTSSLFSSTIANSQSASNVFGGNSSFANNPVFGGGASFGGKASFITAAPVTSMFNQSKNQSSGFAAFARSGISGFGSLAANQQSNQSSVFSGNTGFSSLSKQGNNSSIFGGGLQNTNMRYLTSKQASVALRPFYFAVHPDRFHNPLIKNSNEKALQEFNGYLNDICSPKYLSPKPIKIMFYITDKNNNRNQKYRKISLELTGNDIRSIIISTLQICDLSTDYIPPQNCFDGFEFRKNSFIKINLKSSLLKCRRKAIDTRSFHKRFVCALKDEMDILKRKYDINEISWCMEWSITHLRRNLVAFSRLMDNLPLNEAFIVKEILRGSILRFGRGSYICCDGGLQLGVNDVLEDWRKLCLSANSFCQQLNELKSIQKYITEFLGHANIMISNKIPLIETLHHLRFLNRQMLLYGENRKIATKSFKMVVIEIMSIYDELSISKNGHLLVPCNVNIDHLIKFLVENSCESQKRQNSFRYVVDEVNILCKQCIVELNIEDIDWNNDLNIYDIKKCLEKLKNVDDEVRALLNGLSILLSNNQSIYVMNDGKLSIPVDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULX8</accession>
    <name>A0A0N4ULX8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2701</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULX8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULX8"/>
    <dbReference type="WBParaSite" id="DME_0000882501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000882501-mRNA-1"/>
        <property type="gene ID" value="DME_0000882501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000882501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33075" checksum="B8AA37EBA19861F9" modified="2015-12-09" version="1">MIVSPCPPIIYAVPNITEYVLSTLGERCLVLSILVPTAIVYGLILLIGLFGNICTCVVIAHDKTLHTATNFYLFSLAVSDLFILIIGLPMELHDLFNSIYPYRFGSLVCKLRAFLVEFNSYASILTILAFTMERWLAICLPLRSRHFSKLDRAFKVIPVVWFIAFIAALPVAFIVKVNRVLLPPDAMNRPWTRLVSRDGLTIINTEFCAMDINQPNSQKFIIYFAFTLFFLIPVAVVAVFFLSWFPFHIQRLLTVFLNESNSENTTLQTLFTSVFYISGNFMFGFALNLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM14</accession>
    <name>A0A0N4UM14_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SMG7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10504</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM14"/>
    <dbReference type="STRING" id="318479.A0A0N4UM14"/>
    <dbReference type="WBParaSite" id="DME_0000886601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000886601-mRNA-1"/>
        <property type="gene ID" value="DME_0000886601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5812430at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000886601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="18866" checksum="A0213C55CA00091B" modified="2015-12-09" version="1">MEGQNLMPEEQGMKNEINSVLPPPPGLIAATQQVGRSWPQPTVLPQSTPSLVSGYASMPVIPYPGQPVQQFNPTMMVPTANALYKGGGAPDVHSQTSSNDGSSGSEKRRGGRAVLPPAPVSAISHQKGTSLSLAAVPQSMGIQKQNRLDEVPQDLTSSRQSFRIAMSQPFEFFVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM15</accession>
    <name>A0A0N4UM15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10505</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM15"/>
    <dbReference type="STRING" id="318479.A0A0N4UM15"/>
    <dbReference type="WBParaSite" id="DME_0000886701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000886701-mRNA-1"/>
        <property type="gene ID" value="DME_0000886701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000203">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01760">
        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="10">
        <location>
            <begin position="275"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000886701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39978" checksum="79CD5C4383DA7000" modified="2015-12-09" version="1">MLTVIFRKIFNFNLWLISYNFFIPYFRAGHRGRRFEDSTLGSESDARIFSDDDDRSRVSTSTDITSVSRQHHANAYRKRRNRRRFRQPSRASSFSSITESSMSLDVITVTLNMDTVNFLGISIVGGAVALDGRIEPGDMILQVNDISFENFTNDQAVDVLRESVARRGPIKLTVAKMWDGGPRSAFTVPRHRDEPVRPIDTQAWIQHTNAMRGMPSILEGSEGAPTPVPGHYGHAASSSTATSNGSGPSTIVGGAHVRLDITSDKKKIVQMMVMPNSGLDIKNRTWLKIPIPMSFLGSDLVDWLMEHVDGLRDRKDGRKFAGELLKEKLISHVVNKITFTEQCYYILGEECTGNCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM25</accession>
    <name>A0A0N4UM25_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2723</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM25"/>
    <dbReference type="STRING" id="318479.A0A0N4UM25"/>
    <dbReference type="WBParaSite" id="DME_0000887701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000887701-mRNA-1"/>
        <property type="gene ID" value="DME_0000887701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000887701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33410" checksum="BB1A98002FFB6361" modified="2015-12-09" version="1">MYHRILLLPTMISFKSPLNFIFLTCPDELSGVCSFPTATIHLAEENWYFNPTLKYEVNVAIELTNANVNDHLGMFQLIYETIDEEGKKIVSYHRSVFLKKSGYVFVKQVAFFLFYPLYYFQILSDPYARTLRVSFTDRFKEIQSRTTSAIVVQLQNKFLEIESGVIMVEAKLGFMSSFLFYWPFISGIVIFIFISSIGVSFLLIFWFWRGFSMIFHKYTSMNYADIKNDTNALLASSTFQTKEDEKYSESYSLAQSSIKCSSTQYDSMIKFYLRHRRRRSTKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM36</accession>
    <name>A0A0N4UM36_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vps5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2735</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM36"/>
    <dbReference type="STRING" id="318479.A0A0N4UM36"/>
    <dbReference type="WBParaSite" id="DME_0000888901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000888901-mRNA-1"/>
        <property type="gene ID" value="DME_0000888901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000245">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000888901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20473" checksum="0FDC2CD7819950CE" modified="2015-12-09" version="1">MDLCLDLADSFARVALSLEKWSSQVAGRELQQIIARSIDLFDKIKKLESRVATDEELKQSDTLRYYMRDTSAAKDLIYRRMRCLANYEAANKNLERARGRNREIAKAEAEQNETCKKFEEISEVAKVELQDLKRRRLAGFKKNLVDLTELQIKHAKAQIALLHQAATAFEKELKRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM37</accession>
    <name>A0A0N4UM37_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8.9 kDa family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2736</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM37"/>
    <dbReference type="WBParaSite" id="DME_0000889001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000889001-mRNA-1"/>
        <property type="gene ID" value="DME_0000889001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000889001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11853" checksum="1B2C2DF0840AEC56" modified="2015-12-09" version="1">MTVWLTCFKGKFCNISANSVYVPNLCADDSDKDKCMCRSCCRYDEFGNGAVKRVSDNSYGGAETGNCHGSEHVMVRAKIRIKLTNRKKQRIQRSFNDLKLKDSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM64</accession>
    <name>A0A0N4UM64_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2769</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000079">
        <property type="protein sequence ID" value="VDN52796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM64"/>
    <dbReference type="STRING" id="318479.A0A0N4UM64"/>
    <dbReference type="WBParaSite" id="DME_0000892301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000892301-mRNA-1"/>
        <property type="gene ID" value="DME_0000892301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007415at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000892301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35966" checksum="9453C90F9DD664A8" modified="2016-06-08" version="2">MRHQLPNDAPCPRLCFIEKNHPSQEYGYNLHAEKGKPQFIGVVDKGSPADRGGLKPGDYIYAVNGVSIIGENHKQVVQRIKENPLHCELLVASEEESEWYKRHEIPITLQLPNIIRVYSHKNNLHNSSPTPAAAVWYAPKVCYLFSFFQLLFSRKIDPTDEFGFNLHAEKNRGHFVGAVDKGGIGELAGLQMGQRIVGVNGQLIYPYTPHKDVVSLIKMDPLRTDLLVASEEVDQWYAENHFEYSFDNVVLFASSKNFNVSFNSFSQTKFFYFNDDIFSLSAEEARSRLVHQKKDPRRDSHMTLEEKYRLVSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM70</accession>
    <name>A0A0N4UM70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2776</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000079">
        <property type="protein sequence ID" value="VDN52803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM70"/>
    <dbReference type="STRING" id="318479.A0A0N4UM70"/>
    <dbReference type="WBParaSite" id="DME_0000893001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000893001-mRNA-1"/>
        <property type="gene ID" value="DME_0000893001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000893001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13737" checksum="DAF9E5FFFD6C2645" modified="2015-12-09" version="1">MKNFDLPRIGENITFFPMFIDAEQIVEHWYGEHSKYEYETPGWQMGTNYFTQIIWKATEEIGIGRAKIEANLNDRPTDDETNFEQVIVAFYRPAGNNNRNGQFAANIQKPINISDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNL8</accession>
    <name>A0A0N4UNL8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3187</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNL8"/>
    <dbReference type="WBParaSite" id="DME_0000950101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000950101-mRNA-1"/>
        <property type="gene ID" value="DME_0000950101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000950101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19474" checksum="108BB6E027DEC1FB" modified="2015-12-09" version="1">MNVNDISGAANKYWSQLKICLQKSATSTLGYSSRKCASWVSEATIQLSEKSAKARILGDPDYRAVRRITTTAARWDRNRYWNDMALRMETVLPSPQTITREGVSEMVRYINGVPIRAVKNRLRRWKEFFEAKLNHDAPSIIPNITDLPVELYVCNCEPLTEEEILSVIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPE9</accession>
    <name>A0A0N4UPE9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10762</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001244">
        <property type="protein sequence ID" value="VDN60789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPE9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPE9"/>
    <dbReference type="WBParaSite" id="DME_0000983201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000983201-mRNA-1"/>
        <property type="gene ID" value="DME_0000983201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="172"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000983201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35760" checksum="958CB65F4D390115" modified="2015-12-09" version="1">MKVVANHYYIRIRQSLNRAAEFLSDLAMSTSGISVNPEVPVVFLQLSEGKKFRYICFRIDDSEILVDTAVADDELNLTVEDYVNDSKEAFEVFIQDLKKRTNSLTDCRYAVFDFKFMITRLGAGSSKMDKILFFQLCPDGATVKKKMIYASSAAVIKSALGSEKFISFQASGVKIDASCKKAYDDLHNKHLHSYIIFRISDDDTTIIVDKIGDKGAPYSAFVEELRKSVGDGKECRYAAVDVEVQVQRQGTDGSSRLTKVVFVHCPDDAPVRRRMLYASSVRALKATLGLESLMQVQASDLSDIDEKAIKHELMSHQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPI8</accession>
    <name>A0A0N4UPI8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3456</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000135">
        <property type="protein sequence ID" value="VDN53483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPI8"/>
    <dbReference type="WBParaSite" id="DME_0000987901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000987901-mRNA-1"/>
        <property type="gene ID" value="DME_0000987901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000987901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23205" checksum="285C5E7CE76101A9" modified="2015-12-09" version="1">MINRVEMSKCTFWRMLVDRLSSTSLLPIKYLIDLHLGSTDENCRKTMETKNDAVLSREQRSISKREQLEADSATNSSFTQTKPSLEHFMEERSACRATEQAEPVESEIDECEDEINSQQEPNEDIINIPDFKLYRASLWKRLRGDVSEGSDDGDDQKKWSGVHQQQPSSRDHRFLNDITLALKRLKFQSRQIRRSCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPM5</accession>
    <name>A0A0N4UPM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fer4_23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3483</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000138">
        <property type="protein sequence ID" value="VDN53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPM5"/>
    <dbReference type="WBParaSite" id="DME_0000991801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000991801-mRNA-1"/>
        <property type="gene ID" value="DME_0000991801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000991801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11841" checksum="98FAEDBD3FB14269" modified="2015-12-09" version="1">MISEMVRDSNGVLIKSIKDRLIRWKEFFEAKLNHEAPSVAPDIADTFPEAYVCNCEPPTEEEIISVIHKLKVNKTPGEDGLQTELFKCCPSSFITHLQQMYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPW5</accession>
    <name>A0A0N4UPW5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000150">
        <property type="protein sequence ID" value="VDN53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPW5"/>
    <dbReference type="WBParaSite" id="DME_0001002501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001002501-mRNA-1"/>
        <property type="gene ID" value="DME_0001002501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260275at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001002501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15311" checksum="7E9FC6D76F95F35F" modified="2015-12-09" version="1">MLSIVLYDVNFTLSHDRIHLRSNTTCMNNVITEGHLRWLGHILRRLPHELTHISLFAKPCDGWRQKRGGPIKTWTDMVEKDFERIGGPAIYGVRRWKKEWLLLMSTTASDRAAWKRLTLVAVGASLTSNGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ10</accession>
    <name>A0A0N4UQ10_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10834</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001255">
        <property type="protein sequence ID" value="VDN60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ10"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ10"/>
    <dbReference type="WBParaSite" id="DME_0001007301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001007301-mRNA-1"/>
        <property type="gene ID" value="DME_0001007301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041120429" evidence="2">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001007301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="24359" checksum="6BDD487CC8C32249" modified="2015-12-09" version="1">MELKYLLTLSLVSIIIKAYPEGEKLAKVEVPASEIKATTDFIAGGADSAGEAAKSAGDKAKETAEGAKEMADDAVKTVGDKAKEASDTAKTVAGNAAEAAKGAASKVGEATKDAADSAKSAAGDAAKGIRDKAKAASETAKNMADDAVEAAKDVASKVGETAKEAADAAKNVAGDAADAIGNAASDVGGKVKDAAGALKDKASTDNFVKNSQNYLLFNDFFGVCCIIESGEGFTNLKEKIGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQI3</accession>
    <name>A0A0N4UQI3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10861</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001261">
        <property type="protein sequence ID" value="VDN60888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQI3"/>
    <dbReference type="WBParaSite" id="DME_0001027101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001027101-mRNA-1"/>
        <property type="gene ID" value="DME_0001027101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001027101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="40" mass="4428" checksum="C99C598FCC09BD35" modified="2015-12-09" version="1">MYFHSGKNKKISFISGAGGSIYFGDTDISLLPELVWTSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR45</accession>
    <name>A0A0N4UR45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3956</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000230">
        <property type="protein sequence ID" value="VDN53983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR45"/>
    <dbReference type="STRING" id="318479.A0A0N4UR45"/>
    <dbReference type="WBParaSite" id="DME_0001051601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001051601-mRNA-1"/>
        <property type="gene ID" value="DME_0001051601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="169"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001051601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44324" checksum="4EBF1D750D784E14" modified="2015-12-09" version="1">MVEQTVAVSHVDDEKTRALAAYRRKLVEYREVEQRLKELRKKEQEMQKEHDKSENDIKSLQSVGQIVGEVLKQLTDEKFIVKATNGPRYVVGCRRSINKEALKQGTRVALDMTTLTIMRQLPREVDPLVYKMSREDPGSISYSEVGGLNEQIQLPLINPDLFRRVGITPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGQVKIIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEVLKIHANKITKHGEIDYEAVVKLSDGFSGADLRNVCTEAGLFAIRAEREYVIEEDFMKAVRKVGDAKKLETKLDYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URB1</accession>
    <name>A0A0N4URB1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4011</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000246">
        <property type="protein sequence ID" value="VDN54038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URB1"/>
    <dbReference type="WBParaSite" id="DME_0001058601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001058601-mRNA-1"/>
        <property type="gene ID" value="DME_0001058601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001058601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8390" checksum="722D16B3FA989E04" modified="2015-12-09" version="1">MSTIEFREGVQKSDFYPILLARCPATCGLCDQPGALGECPDRSDICPTITALDPSVCNRNNVANMCMKSCNLKTCLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM6</accession>
    <name>A0A0N4URM6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4117</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000306">
        <property type="protein sequence ID" value="VDN54144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM6"/>
    <dbReference type="STRING" id="318479.A0A0N4URM6"/>
    <dbReference type="WBParaSite" id="DME_0001070801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001070801-mRNA-1"/>
        <property type="gene ID" value="DME_0001070801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001070801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21670" checksum="5E7DE193110F2220" modified="2015-12-09" version="1">MNSFFYCIKLRNYQVYQIITKIKYYFFSEINLNFIISIIFWNQSTVNVIGTMNVIQFACQMMAENEKDKDGQRGVIINVSSICAYDNNSLHAYSASKGAISSMTSPLAFEFAKHGIRFMAIAPGLFSTPMINNLMNSGLEERLKYLESIVLSPKRFGNPLEFAALVHHIIENRYLNGEVIRLDGGLRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URN0</accession>
    <name>A0A0N4URN0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10953</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001298">
        <property type="protein sequence ID" value="VDN60980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URN0"/>
    <dbReference type="WBParaSite" id="DME_0001071201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001071201-mRNA-1"/>
        <property type="gene ID" value="DME_0001071201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230043" evidence="2">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001071201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31509" checksum="9150F051E9A37253" modified="2015-12-09" version="1">MFAVILPFFFLPLTFAGNADIEECVKLVGDKRRPIVNSCPEDPVCSSIFVYDQQDLPAVLANNLREDQDYKIPELCNKIKDFAAKTCPRTCAMCCKTKEFNCHDVSPDACRRLDRNICLTVPSVALSMCPFTCGLCHRPGAAGMCPDENENCAAIFYLDPTCSTDFMKRSCKKTCRLTDCLPVSASDVDVEECVKLVGIVGDKKRPTVNSCPEDPVCSSIFVYDQQDIVLANNLKECSTCFLSVNIDACQKLGRNICTISPSIALSICLCGFCDRPGVQMKAKNVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URR6</accession>
    <name>A0A0N4URR6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4152</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000334">
        <property type="protein sequence ID" value="VDN54179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URR6"/>
    <dbReference type="WBParaSite" id="DME_0001074801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001074801-mRNA-1"/>
        <property type="gene ID" value="DME_0001074801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="60"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001074801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27053" checksum="678784D975E6C70C" modified="2015-12-09" version="1">MGFRGRSNYAQMNRMNRGGPSRFLYGRIMKNRNFFRNRSFEFRKLPENVKCKEFEVSPDNILCFSGFQNVFTAQHDFQLEINGRVYDNVNHFYQLAKTEALCGVTSLLMVEGSEGDGRGRAKDYNTLAKNILRINKISRSAAEEWRRGAGLEAMQRALLAKVEQCEELRQALLDSDQKLLVHCFGGDDFYASACNNKYLLDWARSMSTNKGIIKVIFTLLFEIIAQFFVFLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URU5</accession>
    <name>A0A0N4URU5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4180</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000365">
        <property type="protein sequence ID" value="VDN54207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URU5"/>
    <dbReference type="WBParaSite" id="DME_0001077701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001077701-mRNA-1"/>
        <property type="gene ID" value="DME_0001077701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041120199" evidence="1">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001077701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15308" checksum="E076B23265B8E88A" modified="2015-12-09" version="1">MFAYLLILATLCNFANGGGVDINVCVKSVPVGQEFKKRPSVPVENCQDRDMACTEIFKFMPNNGAILANNLKPKFLYFLLALQKKRKAMSFSDEDYKVPDDCQKDQYKMLARQICPRTCALCCLTKEYNCQNGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URZ3</accession>
    <name>A0A0N4URZ3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4224</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000430">
        <property type="protein sequence ID" value="VDN54251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4URZ3"/>
    <dbReference type="WBParaSite" id="DME_0001082501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001082501-mRNA-1"/>
        <property type="gene ID" value="DME_0001082501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001082501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17130" checksum="5769E5ABD3D5427A" modified="2015-12-09" version="1">MCFFLGYANEVGESFRALIPVSFVRLSYIVSFGYVCADIADKCQKTYRMKYSTNEERNRNVTLRAMDTFVWQALASVIVPGFTINRICALSFKILKMATRWSLQRQKWTTTAIGLGSIPFIVKPIDIAVERGMNALIRKYYPDDIFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US16</accession>
    <name>A0A0N4US16_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1524 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4246</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000465">
        <property type="protein sequence ID" value="VDN54273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US16"/>
    <dbReference type="STRING" id="318479.A0A0N4US16"/>
    <dbReference type="WBParaSite" id="DME_0001084801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001084801-mRNA-1"/>
        <property type="gene ID" value="DME_0001084801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866796at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001084801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22406" checksum="028B73B85EC0FEB8" modified="2015-12-09" version="1">MGIQEGPNVNADDEALKPFRRSITKQSISSEMAMERINRKIKQQFWIMLGTPKKSEDMDFNVEKVEIMHYLPHHGVLTPDKSTTNLRIVYDASAYLQGKKSLNEVLYRGPNDEFNERIAEYDQPKTIKNNFLGINWIGFQINSSTFMEPEQDTQESASFLIYTKSRIAPIKGIFTPRLKFVFAVLVSGGVGYSLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US96</accession>
    <name>A0A0N4US96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4319</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000727">
        <property type="protein sequence ID" value="VDN54346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US96"/>
    <dbReference type="WBParaSite" id="DME_0001092801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001092801-mRNA-1"/>
        <property type="gene ID" value="DME_0001092801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849517at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001092801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16426" checksum="DA86923B21E59D91" modified="2015-12-09" version="1">MFKKLYKKGKQCEAGWPCCRPNSICNKDGLCETEKGLNEIELHGKFPCKKSALDAMNKFRIQLAAGNISAKNGNFPMGKEIYKLRWNCTLQALAQQVATECEYTLPRMDPSDIGEVYLVLNNSSSKSEQNFQKNWEMMKRMKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USC7</accession>
    <name>A0A0N4USC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4351</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000925">
        <property type="protein sequence ID" value="VDN54378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USC7"/>
    <dbReference type="WBParaSite" id="DME_0001095901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001095901-mRNA-1"/>
        <property type="gene ID" value="DME_0001095901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001095901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4407" checksum="6D3FC7669BF4D1EC" modified="2015-12-09" version="1">MLWVTPVNGNAKVVVVSSVVDSVNSVDEKIVEVFGAIFDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2J9</accession>
    <name>A0A158Q2J9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Str_synth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4635</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2J9"/>
    <dbReference type="STRING" id="318479.A0A158Q2J9"/>
    <dbReference type="WBParaSite" id="DME_0000027501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000027501-mRNA-1"/>
        <property type="gene ID" value="DME_0000027501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="4">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000027501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39959" checksum="F4B92C1DA51C0030" modified="2016-06-08" version="1">MSLLTRRIVGEAPMKMEERLPEDISKIKRKPRSDSTLLPSRPSLKGALEVNNILGKAEYLLKDLIKGPESIVVEGGGYDLEPVCGRPLGIRRYRKDELIVMDAYLGIFTVNFAQGTFKQLLKGGLKINNEPLMFLNDLDVVNEDLIIFTDSSSRWDRRRFFSILLEAIPNGRVLTLVPSTGKVTVIMDNLFFPNGIQMLPDNESFIVAETGLARIKRHWLFGRKKGNSQIFAENLPGLPDNIRQSLQKTYWVGLAAIRRHQQTSIFDFFADQIALREILLKLIPHRYLHFLLAFKSHHAMIIELDGNGKIISSAHDLTGSVISDVSQVTDSSKYLYLGSFHANFIAVIPKQAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2R8</accession>
    <name>A0A158Q2R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Nidogen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS5056</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2R8"/>
    <dbReference type="STRING" id="318479.A0A158Q2R8"/>
    <dbReference type="WBParaSite" id="DME_0000069601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000069601-mRNA-1"/>
        <property type="gene ID" value="DME_0000069601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF64">
        <property type="entry name" value="DENDRITE EXTENSION DEFECTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="959"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="15">
        <location>
            <begin position="123"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="15">
        <location>
            <begin position="504"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="650"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="922"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN55083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000069601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120219" checksum="ADF4439FBE3BFFD9" modified="2016-06-08" version="1">MSLSMRVNPERIAARLRIEQEIEMDKLFNRNRRQLATPKEISISITAPLFSSRLFEYGHDVGDNLIPAETDAGIKISLTNPVRLYGKDYSTIYILSNGGIGFDASSKNYQTRVLPSEIALIAPFWNKNDLKNGGHVYYREVTGGRTLERGQSEIRYQYDMTVKVKSCILVTWEKMQPVATTPLPDENTNTFQLALFITDNGTFANYIYKNIGWTQGAEAGFNKGDESDFYALPTSGTGNIMYLEEYGNTGIPGEWMFLLGDNRVERCKAGIKGDTCDEECSTDEWGPDCVFCCHCNAGSCNTVSGACISGQCAECWFDAPTCQKSLLFLLICWCSYKIRNINLEDQHCRSLLNPCAHNAISFTDFDRCGEPIQRCQCLNGYEGDGHKQCLDIDECINNDICHKHAVCINTPGRFFCQCAEGFNGDGITECIATFLYPYEDKSKQLLSRTKNSHVVLHLRNPMVLFGEVHDTLTVSTHGIIAIGEVDSTKLGNKLDMMSVHGVAPFFAPMDLRKGGQISVDETSDNEILARATQTIIQNSFDNSFKAESAVVVTFFNVTNGTIKGPGNTFQAILIAGTNKLHENVTYVQMLYKDLRWSENAEAGIMTLNEVNSVILPGSGTEGIEQLSQLSNIQTPGQWLYRIDADDVPPCNLPSQQPPYCDADPSSAINRKQPLQPKLTKEPSSPRKSPSKPLSEQRPPIAVAEAFKPDLIEVAAPRIIQPILIEASSPPQPIKTHKFFDIATTTRTTTKLFTPILQSQFTKKINETLHIPIISIDSRDIDDLPPDAFDITFPPFITVVPEVITRVPKLKGIFDDSSSPIKLPVTSSSLSEMPTTASVAKSRMIGEEKNLQEKSPFVVSNKDVLFAETSGSDLNLTKPPITMFADDNTSTENTEVFGVDNSLFDYNPTKLVVKPIETKKSMPTKPKLVTAPSPAGSATHGPFDNKSGDKLETSTSNLAVIIPTAIIAVWLLLLAIIALFCCCRKKRAERHFRDLYFPNHQIRPLAMSYPGRKGSKTFSGSYEDHLEKAARLSSELGSYSQNGRISLYGSYWNVANPAPTTTSNAVTNRHSPFAHYASQQIAYLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3H3</accession>
    <name>A0A158Q3H3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemicentin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6764</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3H3"/>
    <dbReference type="STRING" id="318479.A0A158Q3H3"/>
    <dbReference type="WBParaSite" id="DME_0000240401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000240401-mRNA-1"/>
        <property type="gene ID" value="DME_0000240401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000503">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="408"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="498"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="649"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="739"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="827"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1193"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1285"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1382"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000240401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1597" mass="175931" checksum="9F31BD9559AEDE5B" modified="2016-06-08" version="1">MVSGDKAAPPSTSSLTFVFDTTGSMNDDLLQVQDGAKKILDTVLAQREKLIYNYIYVPFHDPNIGPVFSTTDSYAFQRHLNSVNVVGGGDCPEMTLSGIQLALETALPSSFIYVFTDARAKDYHLEDQILNLIQEKQSSVVFVMTGDCNDRTHPGFKTYEKIAAASFGQVFHLEKTDVNKVLSYVRHSIAQKKVHILYEVHERGGSNLHQIPVDSYLSELTLSLSGDKDDNEFLDISIIDSEGKKVDKQQFSNESGTIDLNNIKLIRIKNPVPGIWKVRTSSRLRHTLRILGHGAIDFKYGFASKHVGGIEQTHPRPIAQENTYLVINMTGLIPPGIAREVTLVDYYGKEFLSKPAILYKKNPYLYHIGPFIPPKGLFFVRIIGEDEKGLQFQRIAPTAISAVQAAGPRAYMAERTRTTLSQPVNLTCSVASRTEFMLYWFKGNVKIAGPLFYPYSVTTVWTIDEVAADDQGEYRCVVISDYGNYSVATFLEAREPVPEIIAMRNESVVQGGYGYLHCRTQNPHATIRWMRENSLVGNTDKTRLFPNGTLLIKSVDTLDAGLYRCIVQTNGGRVDAVASLKVLQMPTATVYPKSLFFVNGESFNLSCEATDDLVVLHASEIDAGTYECLARNNAGTHLDNSIAVMAVPPKVRVTKDKQMIGRGGRVTLECLISGGNPRPKIVWYRNGREVQPYRYIHIDDGTLTIQGVQDSDAGHYVCVAQNIAGRDVGNMNLEVGSMPTIVPTPEAVHVNIDRSITLQCRAIGHPLPKITWYRNNLPIDQTGGHFAVLPDGKVSLEDQDRYTCVAKNTFGRQDKTTVLMVVGLISPVLGHAPPEEQIIEGESLRLSCIVVLGTPKPILQWYKDAVPVQASDSIMIESGGSSLLIKNGSKKDEGRYTCVAKSPAGNATLNVNVQLIKRPIIEESGTQEFTVSAGETVDIPCATSGIPEPKVTWTYEDRPLSSVGTDYVILPNNALRIYSASLDDAGKYVCKASNIAGDIEVSLGLNVLSAPVIAPGQVSYNLIQGNPVMLTCDVEGEPEPNVTWYLNDEIFTEGTIDSDGSLTIENTNEFHRGQFKCLAENSIGKDERVVTVTVHTAPTIEGSGQLKIIVANVNETVILPCPARATPPPTRTWSYEGDRIFSGYNYGSEIRFENEGGLEIVTPQMHHTGRYTCHVSNLAGDDHIAYLLKIREPPIIISDIPGTIDVVLGLMLEIPCRAIGTPDPEITWEKDGFQVISGDIYQIDSFGTLRIDNTQLIHSGIYHCLASNPAGKDTRKTIVVVQEPPKILPTTLSEYTTVVDDRIEMRCFATGNPPPVIIWTRKGLTITETSVGLHTTEDGTLVIDSVTDDDAGHYTCRANNAAGDAEKIIRLSVITPPDIPDPDVPLTETAIVGQPFSLYCPVFSNPIPQITWHLNDRPLVEDDYNIVLSDDKRRLHVLKSRITDAGYYKCTARNPAGEASKIFEVEILVPPHLNELTNKRKLTVRESDRVDIGCPVTGSPLPNISWLMNGQLLKDGETKQGVTLSSSGKSVIIDSAQLENEGIYTCVANNKAGSLDIDVQLIFMKSIEDERSISDLGFRKMPRFMHLDKLLCDEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3J2</accession>
    <name>A0A158Q3J2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6878</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3J2"/>
    <dbReference type="STRING" id="318479.A0A158Q3J2"/>
    <dbReference type="WBParaSite" id="DME_0000251801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000251801-mRNA-1"/>
        <property type="gene ID" value="DME_0000251801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21504">
        <property type="entry name" value="PPP2R3A_B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000025">
        <property type="entry name" value="serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000251801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46956" checksum="0989C9BD16711795" modified="2016-06-08" version="1">MPEICKAAGIPIYWKKPVFDSCARNQQETISLADFSVWWNRMTSTAHDEASRFIFSLAGPNRNYLIKEDFTSMLQDLIDSFPGLHFLREAQEFHSRYVETVVVRIFWSVNRSWTGRITANELRRSNFLQTVRKLETTDDINTVTDYFSYEHFYVIYCKFYELDKDHDLIINKIDISHHANGALPSPIIDRIFSGAVTRSSFGRRIRTAIDTITYTDFVAFLLAEEDKKHPTSIEYWFRCLDLDGDGLISLYEMEYFYNGVKSKMDQHHIDSMRFDDVVCNLLDLIQPRSPNAIALSDLKRCSLCTRFFNTFVNWVKYYEQESSEGERATVTDGDEELNDWDRYCLEEYEALMADDQEEEPEDINLNLDDDDDLTNGTNVSTTVNMTLRDFDTKRSMPILEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3X8</accession>
    <name>A0A158Q3X8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tub domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS280</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3X8"/>
    <dbReference type="STRING" id="318479.A0A158Q3X8"/>
    <dbReference type="WBParaSite" id="DME_0000341401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000341401-mRNA-1"/>
        <property type="gene ID" value="DME_0000341401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF2">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="8">
        <location>
            <begin position="57"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby C-terminal" evidence="7">
        <location>
            <begin position="853"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000341401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="935" mass="104915" checksum="4F9C0B988FADD4A5" modified="2016-06-08" version="1">MKIFWESDNWPGAVIQPGITCLGWMPCADKPGFGLLAAGSESGAVGVTSTEICPREDDLLRNNFNLRGHHSAISIVAWNQGQMKLASCDLSGIIYVWVPNEERWSVELVNDRGVKVRDVCWSSNGNLALICYEDNFVLIGSSSGQRIWSSSFTVAVSCGVWAPDSHEIILGLSTGVIQVLTEQGATIMERAISSFSIQRLAASPFRNNGKWTLAICSSSNLITFLRNYDETNAVEWQSEDPVLDVQWSSSGTLLAVVTKPNRLTILNERGIVMYSKPFPFHISKTLTAFTWAHNDQVIVAAAGGHLVIGRVVFGVPPLSSLVTYNIWVMMGHSSQRVDSLPLPSRERNVIRELDHHVIRCRMPSKETLCESVCEPSAWRWYCTVRPIPHRMHCYTLCFEHMGGLIPVLMGRQINRIIPQFYISLLDSSVFTPSSHCSTMENGCSARVEDVGAFNRPSVQRNSVWRRSKRHIRALMNRRVASCQVPSKTNGKLVQVSSNVWCTRFKMTSLAASLLPPSLAEVIYKTSVLHLQPRQMTVRIADLAKRRKKNSSNINGEDKYHSLRQRRGLVDVRAANMAAILSEIYAFENDEYSLRQCLLSEEKDVFDDDDDVALLEERILYENVFAEFNELRAAVDRHIARMKCFANDLEKSSLKLETVNASDISSTSLRAQKISVSLRDDRLSANKNRVELARPSTSDQWPRYYDEIEYIDEDDSVAICTKNDHYSELIPLVANTSRLSDPSRKGLRQLNDISSVLDKLSKLANDLTTRCAVGQVSNQASPSHASNIAMGYNGNTTTVLSLRTQLKDIATRVTQIERKINYGDELLGEVCGDLQQRIQHIKRILGEHPPTVDEVSFLTMYNKAPFWNEASQVYQLDFGGRVTQESAKNFQVEFDSKQVMQFGRIENGAYTLDFRAPFSAVQAFSVALASITQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q437</accession>
    <name>A0A158Q437_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7926</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q437"/>
    <dbReference type="STRING" id="318479.A0A158Q437"/>
    <dbReference type="WBParaSite" id="DME_0000392101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000392101-mRNA-1"/>
        <property type="gene ID" value="DME_0000392101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000392101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14688" checksum="587F79C632591F3C" modified="2016-06-08" version="1">MMSAVVRKIISTTKAPAAIGPYSQAVLINKTLYISGSLGLVPETGVFAGNNVKDQAEQSLKNIGSILEAAGISYKNVIKTTILMADMKDFAVVNEVYKKYFTERYPARTSFQVAGLPLNALVEIEAIAVICDIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q476</accession>
    <name>A0A158Q476_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8053</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q476"/>
    <dbReference type="STRING" id="318479.A0A158Q476"/>
    <dbReference type="WBParaSite" id="DME_0000417001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000417001-mRNA-1"/>
        <property type="gene ID" value="DME_0000417001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873773at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903:SF1">
        <property type="entry name" value="HYPHALLY REGULATED CELL WALL PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250229" evidence="2">
        <location>
            <begin position="17"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="3">
        <location>
            <begin position="508"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000417001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="56822" checksum="623C21C8E5B52BFB" modified="2016-06-08" version="1">MAKLVVFVLLISPTLACLGGGGGTCCPPSTPSCGSIPPCSSSSYGGESGASRVLSSYVAAPPPKYAAGPPASAYVASGPSGAYSAGGAYGGAGGAYSAGGAGGGAYSAGGAGGGAYSAGGAGGGAYSGGGAGGGAYSAGGAGGAGGGAYSGGGAGGGAYSAGGAGSGAYSGVGAGGGAYSGGGAGGGAYSGGGAGGGAYSGGGASGGAYSGGSAGGGAYSGGSAGGGTYSDSGAGSGPYSGGGAGGGAYSGGSAGSGSYGGGSAGVYNGKSAANYDIADQTYPGAGSLLVPPHKPSPINAPPPPPPPPPPPPPEPVQNYLETAPRPGPVESLEVPAVPEVPRSQPSPFVQPQPIPQPAPSPQPAPYLEPSGTEYDELSERQEQYQEPHGANIGTHKETYKPEQVRVTRPVPPTIAVPSSASLPALPSAPEYQQSIVPAPQKLPKVPLPAPLPSQQLEEEKIPDISQLIPEVPQIPEVPQQPQQQVKPASGNNLIGYEEEETDLEEESDKACNDEELKSIIEEVLNTKEDNLEAAREIEARASKRFSGRFNAIVSNAEFAYVNWYGRRNCQLRVRDRHSLTWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4B1</accession>
    <name>A0A158Q4B1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1981 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8344</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4B1"/>
    <dbReference type="STRING" id="318479.A0A158Q4B1"/>
    <dbReference type="WBParaSite" id="DME_0000446101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000446101-mRNA-1"/>
        <property type="gene ID" value="DME_0000446101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10002886at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="2">
        <location>
            <begin position="768"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Sec7/BIG1-like C-terminal" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000446101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1547" mass="177521" checksum="73339CF53239BBAD" modified="2016-06-08" version="1">MLGEPMKSSFKSDVTDGAMGRGQSAAIMQTKSIFDNVEVARSLYQSFEQLLRIMSSMNEMRSILEAVFHKALLYPTINQRTEALRLIRKIVSNEDRLMDILIISINTQSFTLWKIILDCIVECAFSISIDISLEAIRCINAVLASLSIICEQTDSNSLISNELQEIILEYLPNDQASVVTAFAYNNKREFDTKKNNKKTTSMKGEKTELKSDEANCGTKPTCEERMFDNIQPPQIKIHTPDSHEEELDNTDFNNEISQRLKLLADKISQQNKIGSTDMQVIDSIEEEEIETAELFVKELSSSIVRWNELRSTIEVDEAIKQFSSDFSSNFSSAQNIAFQSQGRKQTQFLNADAIYLTTYVSLSIAFRINIQTNTDKAWFIKEIQQSGCVIYTSDRWVNAVYNALIQQNIFGDIKFTDLSPLLNLVEDFDGRACKIMSDVRRIQQISSKRSDLFIAAHRLCRWFLSASWDGFLKSSSCYVFNYQNQCRTIRPKFMETMNQSLNALHSLINLSVLLNICDRSGAVFERIVEMSCPLEDLRKFAFLKSKNDNEKSNNKWVLQRMDVLSMQLVLDNAITCGLNDFTCWKYIIRCMEYIWEVEKYLFGSKIDEKNSPWMFWKKKSVKLKSDNVDFGDLRSVEDVMNGSDENLLDYHFSAKALYVLFNKIDRLYENAIKQLNLPALKTFLQNIIVANELETHYLKNDHVEEAITFLNRITFIVLKSCQRPLIHLMGLWPMVAQHFVQCACLREDENLIQCSVGCLNDCISGLLITEANGFCFNQILFQPFQDILCSGNCSEEAQKEIISFLATFVHNRSDEIDSGWRPLFGALRALHTTANFEMDAYNEANSVRGTVFDVIVTYLNIKNPNVLLATLMDCISCLLQYAQATGIFFQGSDFVENSNDYIMASTALEYLLEIEKRIHALLISANSTVPHLLHRLLLRERNTQFLDLYSDEFDIAEPLSNVLLEDSLFNDTTESLLPSDLDCQMQLSIPSLPWETLSATKKGCVELYLSFIEGLTAVASTCPVSLQSKLLNTLARLICDLSESKFGINFGPYILSTLTFPMLQRCIRRSKNETENNLKEAIESSFIDRVLLDFLYLLSECATRSTSRISRLACACIRHLIDSSKTFFTRLRWTIVVRSLWNALDMSLTYIRYLMRYYMVDANDPNGDIGHVMISIIEDSSLSQHILLFVKQIFLLDEQFSNEFADKYLAECLPNKFLIFCDEQTEIFRVTIEQLAESLLSHQFLMQIIGYLLLEGVELNANGTALKILQQFNESPKKKNLTNLTSDDITVLLYCANVSLQIAKNFDERAGLKILIQNAFNLCVMPNLCKQLVFSWNLISLTLYDILRSTTHNSTTIANFLTNDTIDEESFRIKQLAKCHKKICLYLCKLEKSLALQRIPNYIRAYTNQQYSLVIENSLIENESQQKFYKLISETETDSLLQDYKRSKTTQSLRNTKRVNPFDESKQILANEKRLYLEDGDIRCAAWADMSLNILNIFANESEENFRRFLPIFYPNLAQLIAGSVDSNIRQFTSDFLLKLPKHFPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5P3</accession>
    <name>A0A158Q5P3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANAPC4_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5P3"/>
    <dbReference type="STRING" id="318479.A0A158Q5P3"/>
    <dbReference type="WBParaSite" id="DME_0000791501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000791501-mRNA-1"/>
        <property type="gene ID" value="DME_0000791501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411991at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000791501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59598" checksum="E719A8801666A9BE" modified="2016-06-08" version="1">MCDPLRPIRNISHAPLRSVESANLFNVANLLVSNCFCEFDDLLFIIRKSMCKNGASGIMEYLINITDGTHYWWPIAKIGRFLRNLGANILENFAVSEEDLRSIIADSSIMGRDWFSNWIRCLAVHESGYYVAVCQPNDIILIFSSKRHLKSPVVLKHSFQRNVSSMQWKIYGENIMTESTERKISKVFKAKRCDDLSCGLSEGSNCLENLFKEPCELVIDSLSAEIDSLSIWARSKVSRMWPSPDGSKLLVAFRCSFVRIYNCNSWEYEEWANFAGGCSAAVWSPDNSFLLLTACNEAMIRYIQFTRTGAKTLIVFKFSYGSSNVIPLFDLSEVASEGSPSIGGTARDMILSPDGCRLVVTFKAINSIDTIDEKYDCILKIRKVISDNMSVIAIFIVRWRPTLLLTPCGLINGADFGNATIVLFYPKFDYGSLLSVVRVWSEARLQHIPLIYGSFAKSILLHRTFDFDDGINQAVLDDFNICFQNDISFEINDDSDQTETSLHSTNSNNVQLFSSQGLYDRLTEHSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5W4</accession>
    <name>A0A158Q5W4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2422</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000060">
        <property type="protein sequence ID" value="VDN52449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5W4"/>
    <dbReference type="STRING" id="318479.A0A158Q5W4"/>
    <dbReference type="WBParaSite" id="DME_0000844701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000844701-mRNA-1"/>
        <property type="gene ID" value="DME_0000844701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="217"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="341"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000844701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="63265" checksum="84F295864215EDCE" modified="2016-06-08" version="1">MKSAIKVDVIKTKPYGGQKPGTSGLRKRVSEFQQEHYTENFIQCIFDGGLGDRKNGASLVVGGDGRFLCSETVKLIIKIAAANGIRNLIVGQNGFLSTPAVSCLIRKRIINGGIILTASHNPGGLSGDFGIKFNCENGGPAPEKVTETIYEVTKTISEYRICHELNVDLNELGRKEFIIEESGPFIVNVIDSVNDYIQLMEEIFDFNQIKSLLVDGIFNRPFNIMIDSMYGATGPYVSAILTGKLGIDSKSFIHAIPKPDFGGGHPDPNLTYAHHLVSLLSLGEHDFGAAFDGDGDRNMILGKNAFFVTPSDSLAVIAANLNYLICYFFTYCLHIFEYIVGFARSMPTAAAVDRVAQASGIVVYEVPTGWKFFGNLMDAGKLSLCGEESFGTGSDHIREKDGIWAMLAWLQIIAHRKMSVEEIVKDHWAKYGRNVFTRYDYEKVDAQGANLMMTFIESQLGAWIGRKFSANHIDFVLSKGDNFEYKDFIDGLISKKQGLRLIFEDGSRIIFRLSGTGSSDATVRLYVDSFINPSDKERLLLPAQDVLKPLVLIALDLSKMAQFTGRDKPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6F0</accession>
    <name>A0A158Q6F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP complex subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3469</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000137">
        <property type="protein sequence ID" value="VDN53496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6F0"/>
    <dbReference type="STRING" id="318479.A0A158Q6F0"/>
    <dbReference type="WBParaSite" id="DME_0000992101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000992101-mRNA-1"/>
        <property type="gene ID" value="DME_0000992101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002056">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000026">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="6">
        <location>
            <begin position="511"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="7">
        <location>
            <begin position="630"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000992101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="742" mass="81669" checksum="021C70FDE6731F63" modified="2016-06-08" version="1">MFHEYFSSICERISPRLAHANAAVVLSTVKVLMKLVEILPEGSEFIGQLTKKLAPPMVTLLSAEPEIQYVALRNINLIVQKRPDILKQEMKVFFVKYNDPIYVKMEKLDIMIRLAQPSNISQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVCTLLDLIQTKVNYVVQEAVVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMIWIIGEYAERIDNADELLESFVEGFHDENTQVQLQLLTAVVKLFLKRPSDTQQLVQRVLSLATQDSDNPDLRDRGYIYWRLLSADPVAAKEVVLAEKPLISEETDLLEPSLLDQLVCHIGSLASVYHKPPSSFIDSAKHPLRAAAATISGVAPVSSDTNNRAGSTAETAAPTVIPSQDTLIADLLSLDLNAAGSGHPGLDDLLGLGSDGLLGDISGATSPPTVLTQSSAPSFGIVNAAQPFGQSAQPFASVMPPTASTGLPVIPASSNPFTPEFGDIFGVCSTASSAIGIQSGYIAPKAIWLEASRGKGTQIEGTFVRRSGRIYMDMVFTNRAMQALSNFAIQFNKNSFGLIPAEPLQVNSPLYPNQSNSASLCCRTDGPVQKMDPLTNLQVAVKNDVGVFYFAVVVPLNIYFEENGQMDKREFLQLWKEIPEQNELQFSLNNTLNLSADDICTKLQQNNVFTVARRNVNGQELLYHSIKYTNQIYVLSELKMQQSSSVLTLSLKSRHVAAISNLNEIFQTILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PMI0</accession>
    <name>A0A3P7PMI0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PMI0"/>
    <dbReference type="STRING" id="318479.A0A3P7PMI0"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="204" mass="23166" checksum="4792F9FF6496C441" modified="2019-02-13" version="1">MENFMCHENLKIDFDLAKNNCFFIGGCNGSGKSALFASLNLGLGGKGSSNDRGNSVKNYIKFGESRSKIRILLTNSGYGNHPDYGEKIAIERIISSRNQSSYLIKSVFQEGRTFREKLVSTRKSDLDQLLSRFGIQLNNPVFWMSQDRSRAFLQDFKPDKIYKLFVIATGLDCTRKCYDTVASYLLDMENIQDSIHEILVEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q652</accession>
    <name>A0A3P7Q652_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q652"/>
    <dbReference type="STRING" id="318479.A0A3P7Q652"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="2">
        <location>
            <begin position="288"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="479" mass="55450" checksum="BD5099F499CB0DA2" modified="2019-02-13" version="1">MNNSLLSLSTHFAQVQFRLKQISQADSCDKDKLLKDLQEFAFRGCTDVEEVKRKIGNNFGLGKEGVNRQKERQMELITQLKRQLEELEKFAYETGEGGLPSSEIIARQKVVIDKLHEKMQLNLELDKMSQSDLQKQVDEALKQLINPIKAKEKLVEQLQTQIVDLERFVSFLQGETADRTPTSFSSTRTKPVKKNIFMNLIGCGNNRFERNELKNTIQGNHYGLVPKHYNKLIIFLFNFLDERARLELAVDSTVQVLEKYLLLSVEHERREIIPPNYLDEVFERSEQEVVSVIRKVFCPALRSLLEHGMNSATVRLSNPFISFGCLPSRKVSQKLNHIWDVILFYYDSKWGRELSDAPVRQLSQSFQLDEIGGRSITSKQILLTTIENIVATHSKLKRTPDAMWKAFVSAALNEKKLPAWIRIIFRTRQVIQQCYSSWAYVARTGCEDCYILLESLHKYNFILPVDLAVRPFHQMKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QHG1</accession>
    <name>A0A3P7QHG1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubicon Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QHG1"/>
    <dbReference type="STRING" id="318479.A0A3P7QHG1"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF12">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY AND RUN DOMAIN CONTAINING M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="5">
        <location>
            <begin position="66"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="274" mass="32011" checksum="AB751E6B6B40119A" modified="2019-02-13" version="1">MHSRVLQESVNEESSANAKKVEEEKMFQEIVDKFFTSIQKEKGLDRQNFRCNSCKKSIGLTFSKYKLCALDGMYYCEICFESGVLNIIPSRLIYNWDSRPRLVHPNNKILLDRINDRPFIRIDVLNPALYHHCPTMNTAKILREKLSFAAMYLLSCRDSVAHDLQMRVWPKEYLYNDIHLYSFSDLITVLSGQFQRHLSSILSYAVNHIHACILCSQKGYLCEICPSNDVIYPFEIETTFRCNICFSLYHKKCIGEMSCPKCIRKEFYANCQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QL21</accession>
    <name>A0A3P7QL21_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear cap-binding protein subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">80 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the cap structure.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp-1 and ncbp-1 that interacts with m7GpppG-capped RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QL21"/>
    <dbReference type="STRING" id="318479.A0A3P7QL21"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000010">
        <property type="entry name" value="Nuclear cap-binding protein subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000041">
        <property type="entry name" value="Nuclear cap-binding protein subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="723" mass="84920" checksum="7EA499CE9D448651" modified="2019-02-13" version="1">MFELITHVGEKSNSSLESNLESLAQVLETDLNTYKDDVIKIVYYCVSHMPCKLTIYSTLVGLLNAKKYEFGEKLLIKILKKLEEHMNASHFSICLNLMTFLADLVNTRVVTLSSFADFLEDLVQEAFEDNIPQVRSDWFIYAILHCLPWVGREMFERKKDILESILDAVEGHMMKRNKSYVEMLRVWTSSIHEQEDYLDCLWAQIMKLRSDDWTERHIMRHYVAFDGQLADALQHNLPKFIPTPHSSSNVYPLPHVVFRLFDYADCPEQGPLLPGAHSIERFLMEEEINWIILENQGNRKECATNLLDYHKKSTVPLNYVILEVIFSQLFRIPDSPIRPIFYGSLLIELCKTKTMPQVIAQAAELLYQRIDTMQLICIDRLVDWFSYHMSNFEYRWSWNDWSSCIEMDHLAPRHIFVREVLEKCVRLSYRQRILEVLPIGFEKMVPEKISICYDLGDEDHPLHSLAVEIEKGFRGRVTAENMIEIIQRENDRSGNECLIIFFSVLLNLARKTFSHNFAALTKYYITFKKLIGESEELQLLLLQTLYDVWKLNHQMVIVITTKLLKMSVIDASSVAAWIFSEKMKVEFLRMWIWELLCIALDHVTGELNRVRSQIEKLRNKMDYHSDEQNRDEGDFSDKEKDEENNDDGNIEDLPARETEAASLQECLKNLLLYILHKFIILMSEHIVNSEMNGSDIETSWFVYIDGRLQNVFQRVKFWCIYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QRR7</accession>
    <name>A0A3P7QRR7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QRR7"/>
    <dbReference type="STRING" id="318479.A0A3P7QRR7"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="88" mass="10014" checksum="40F0826A17AB306C" modified="2019-02-13" version="1">MVPRNMVVELEKMERYAGPVNPSLYPQMAVVLLGIGLFFMAWFFVYEVTSTKYTRILLKELLISAVAALFLGFGSVFLMLWVGIYKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7S918</accession>
    <name>A0A3P7S918_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7S918"/>
    <dbReference type="STRING" id="318479.A0A3P7S918"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="191" mass="21736" checksum="455A7B0B6BE4F624" modified="2019-02-13" version="1">MKISDFFPETYSSFKENEYKFFRDAAGRELTLIDIPGAERLRKRLLHKYLSERRSIRGIIFVIDSSTFGRKSRDVAELLYDVLYESRKCVPSLVTCNKQDSSLAKSSRVIHITLEHEFGLINGTREAALDSTDGDMKKRVLTATGKDFQWNDLMTTKIDFIECCAIKGFNGGEDGGRKTGLSSVRDWIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SKV2</accession>
    <name>A0A3P7SKV2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SKV2"/>
    <dbReference type="STRING" id="318479.A0A3P7SKV2"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="97" mass="10381" checksum="EFD6BF5E90C80A89" modified="2019-02-13" version="1">MAIKPKTSVERILPFLNDLDNVLIMTVEPGFGGQKFMEDMLKKVEKIRSLAPILNIQLDGGVNLDNVEICAKAGANLIVSGTGIIKSSDKAKVISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TGC4</accession>
    <name>A0A3P7TGC4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AMOP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001232">
        <property type="protein sequence ID" value="VDN60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TGC4"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056075">
        <property type="entry name" value="DUF7658"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057017">
        <property type="entry name" value="F54D1_6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057018">
        <property type="entry name" value="F54D1_6-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057019">
        <property type="entry name" value="F54D1_6-like_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF60">
        <property type="entry name" value="PROTEIN CBG06057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24678">
        <property type="entry name" value="DUF7658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24469">
        <property type="entry name" value="F54D1_6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24462">
        <property type="entry name" value="Ig_F54D1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24464">
        <property type="entry name" value="Ig_F54D1_6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="10">
        <location>
            <begin position="156"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="8">
        <location>
            <begin position="609"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1334" mass="152678" checksum="2D81BB2C8CFEF345" modified="2019-02-13" version="1">MLPIAFKIKIYQNLSKSIKSINKQDYVNLVPFGPEVGDQKVHPGMLTAGQTIDLHMYFPYYGGLYNYSTLSVNGYIAFATVLDQGPTINVGVDSTDWPKQQDPAMIAPYLCKQQIAQNPSPGMRTGVYYRLILRQSLFGRGSGSNLNFGGTMQQSSFFGQSASQACPSTSDSYVRCDQTSDFFLDEMMRWLQEGVAGAAAFRADAALVVTWYNTASAVSGRSDIDAGQLATYQVIWLTDQPGRLSYVILNYDKLGFDAADFRANSRSGRCQALFNGGNHTGTVPVDPSFMYKNTPKVLAQRSGVPHMVRGRYMFRVDDVVRPAGCSNKTGGTFPMLIYPNIVNMLGEMSVDVNAICLDRAQTYILMIEQRQTASCVVLNPAIARCHLPKIYDWGTKTVYFQPQSGGANDEKAFVGYIYFVPPTLDPMRLDIGNIYDWFKNPIQYQVMPISWYPRNFTNPNLNIMDQNFRISDDTIYGVELGLYVIGYKESLDDKIKKFRPEHRTLCRLARYSNRNAMEYRWKPQEEQINIYQVERWYLNDWEKMNDLFTFRFGYLKLAPLKPNDDSGIDLPSGLVSAPISLHWLWTINNPQFSTTTYSQLDANSRKEFVRKKSLQMCHDWYDEDGAQWNFIRDTETNASCPCVESQAKMDLGRFMPHPRCSQVFRDITCTSMIGAKNCYMSAQNIYGSYAGDGYQTQSSEQTARFPTHYGQVCCYDKEGKLMQTSYQPVVKIIDETPYNPGYPLRAYEFGTHPYMGQFEVPGLSAFHHDYMPYFLCCKFAEFRCQLFYWRRPSSGCQQYQPPAVGHSMGAGSFNTIDNEKFVFNEPGVYTLLYIPKTLMNPEVRIQVRLERYPNRKIDFSLLGRYIGQADLVQPTNATVITGIVIEATGTDRVHVLARKDTRRFRYRTSVIVGNILRYFDTMRLQRFKGVLVYVNNVERGQPEVYVVLEEAQIGVRIRESYSVDIDRLPMYQESMGMLDIALSVPPQYGVRPDGDRTREQVLRQRFNLPRVSGLMRPFPDQSSASFLSGLTINDVNSETYRQQIINNYRIPGSGEPGSDQNVAGVLQWNIPSDNMFTTSREEDKKFEVFPEASMKSGPIFKTAEEYETGPYRFVPRTGQMLNQLLQTCRDLQRNKQTDLQPLQSSLTERFGMTQCPDNPSQIIQECGDSVPCLYDYTMLNARILGMEIQNSWNAFIYERLEATRHYNSCGPINIEYPEYLMKTPSLSSGYMEGDVARFDCFQTHWIKGDNEYKCSLVVDYNNPSNYRFEWNKGSQPWCRSREKDNLFKWLTAIFSTTAIIMVFLCFWCVKQKRIKDAEERGSSVYKAPIRGPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0F0</accession>
    <name>A0A0N4U0F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4386</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0F0"/>
    <dbReference type="STRING" id="318479.A0A0N4U0F0"/>
    <dbReference type="WBParaSite" id="DME_0000002601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000002601-mRNA-1"/>
        <property type="gene ID" value="DME_0000002601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="220"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000002601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35798" checksum="774D99A064A62AD1" modified="2015-12-09" version="1">MLRFDQLKLAYNKFRFNVVLPFIILISYTLLGAAIFRSLELHRDQNEREVFRKSYSYAFDQMIKRIMEIRCDDQIIRNDENLQVKYTKEAIDWLFHYLNFTDIISERTESSPWSWYGAMFYAGQLYTTIGYGLPVAKTKAGQIASIFYIMIGIPIFLIILKDGKRNQGYMKWVQIGENGNHKNNSTIEFDIEENSSFQSNDLKKRRSQDHAFPIPIALTILVFWIGFSAALFCLWETEWGYLTSVYFFFVSISTVGLGDIVPGNKDMMLVNFLLILIGLALLSMCINLIQVLDYIFLNGTKLPKISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0T5</accession>
    <name>A0A0N4U0T5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS4537</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0T5"/>
    <dbReference type="STRING" id="318479.A0A0N4U0T5"/>
    <dbReference type="WBParaSite" id="DME_0000017701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000017701-mRNA-1"/>
        <property type="gene ID" value="DME_0000017701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041474328" evidence="17">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="233"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000017701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="481" mass="56687" checksum="08C38B9865CC05D1" modified="2015-12-09" version="1">MKSTLILLITSLLILNDASPPELRLRDNLLHDYNPLERPVERSEDPVMVTLGVVFQQIINLNEREEKLEVNAWLKYSWKDMKLRWDPLEYQNVTDLRHPAGSIWQPDILLYNSVDSTFDSTFKVNVISYNDGTISWIPPGIFKVSCKIDIYWFPFDEQICYFKFGSWTFSGKEIDLQPGEFDMSDFIENGEWVILKTWDERNEKFYDCCPEPYPDVKFFIHLRRRTLYYAFNLIMPCMLTMILTVLGFTLSPDTCEKIGLQISVCLAICIFLTIMNEMTPPTSEAVPLLGIFFQSCMVISVAATAFTVYVQAVHFRNPDNQRRMGFWMRYILLEWIAFILQMRQPKRENNLKTIKDSWQQRKNRSKEDRTAFSYNDGKSKVIQKIGESLQENFQYFMFHIQIGQYTKNDQNLQQRLRLLDRIYSHVKSIRERSDEEIEVKYIANEWRFAAMVVDRLGLLLFTTVIAITSLIIFTRAPYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1M9</accession>
    <name>A0A0N4U1M9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS4881</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1M9"/>
    <dbReference type="STRING" id="318479.A0A0N4U1M9"/>
    <dbReference type="WBParaSite" id="DME_0000052101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000052101-mRNA-1"/>
        <property type="gene ID" value="DME_0000052101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="182"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000052101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36620" checksum="192DD65C5D2B38D2" modified="2015-12-09" version="1">MTTRFDFPCASFGTQQSELISTTFNAPTFNAPSIVDTSQHHHSSMHNLSQPSNLLQFHYGNLNENIPSQNHLDQNATRIATGGSFDIVPSNLQTGLTSDEKLCAVCSDRARTVQKKAQYMCTGNKNCTIDKRFRSRCQYCRYQKCLAVGMVKEVVRYGSLSGRRGRLPSKTKLLHSDDPPSPPLPLLTIINRAFADSRSTTASYTFSGLIEDLLEFLEEEFRSFLRFVDKIPRYTDLPRSDILMLTEKNFFALLALKLSNRWTKERKLRLDQVEIDVDSVPEPFKILFSKILQDIPQFRRVIERDSLAFAALLALQLLNAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1W9</accession>
    <name>A0A0N4U1W9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4991</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1W9"/>
    <dbReference type="STRING" id="318479.A0A0N4U1W9"/>
    <dbReference type="WBParaSite" id="DME_0000063101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000063101-mRNA-1"/>
        <property type="gene ID" value="DME_0000063101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="289"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="397"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000063101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56080" checksum="E6383D5688120FFD" modified="2015-12-09" version="1">MTEVQQAPIENETNLEDVAKAYMEVRQRKDGPSAAPLDAKIAAMLPKQDIPSANSDDKDRSNDKDKRNRHSSKDRDRSRERDRDKDRERRRRTRSRSRDRDRRRSRSRDRDRRHHRHRDRSRSKDRSPEKPKKKYKFWDVPPVGYEHLTPKEYKELQAAGQIPRNNVQSAVPVVGPSVTCQSRRLYVGNIPFGCSEDAMLDFFNQQMHLCGLAQAPGNPVLACQMNLDKNFAFIEFRSIDETTAGMAFDGINFMGQQLKIRRPRDYQPMSTSYDLGNMLVSNIVPDSPFKIFIGGLPSYLNAEQVKELLSSFGQLKAFNLVTEQSTGVSKGYAFAEYLDPSLTDQAIAGLNGMQLGDKSLVVQLSCANARNSMPAGAFPQIQVAGIDLSHGAGPPTEVLCLMNMVTEDELKDDEEYEDILEDIREECAKYGIVKSLEIPRAVPGVEVTGVGKVFVEFNSKQECQKAQAALTGRKFANRTVVTSYYDPDLYHRRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1Z3</accession>
    <name>A0A0N4U1Z3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5020</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1Z3"/>
    <dbReference type="WBParaSite" id="DME_0000066001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000066001-mRNA-1"/>
        <property type="gene ID" value="DME_0000066001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048634">
        <property type="entry name" value="SecD_SecF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF108">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="153"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000066001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="711" mass="80221" checksum="3CD9316F4E1DB4DC" modified="2015-12-09" version="1">MHGDGRDYPTLCAYSCVIPYDQYAYFAKELSAQRINQSDNGDNSDETEFDNQTIFDYPLSKLYGNELFMGSNLFGVQKSDTLYKNHSKITHVGSIVLWYSFNVDTRKRKELLRKVTVQLFELSKIDDTTTFIKFNIFGDEIANSEMIRGAYEATKLMIIGFFLLLGFVFFVVWHKLRAKKVPVVVLAAVLSPFLAATVSFAIIAWIQFPFYSIMCVTPFLILGIGVDDAFIMLQSWCLYNTVPSKKDRLTRVFIEIGPSISITSITNMVAFGIGYLTPTPQMSLFCLSTSIACFVDYILTFTLFAPVLYINSGDEQCYIPAKKSIDQMNDDFIHWYSKFICSWKGKILALLFLILLYSLSIFGVMTMKSTFEPAKAFPSDSPLASSLNGVKLAFSEFSPLQIIVNKAPNISDQQEYSAFYEMVTSLESVPNSYGRQWTLLFLKAYEMFDQKIFSFLHAFGFSGQNHYIPSYDNLGYFLRQIRNPPMIKTKQNENGIEVLSSFIMTIVAHNLTEWANRAIYVDQCRSIVNNYPQFNSSIRDGDAAILDLILTVKMDLVGSIAVTVFCMAIVCIFFIVDKIGVFVVTLIISSICFTLVGSLSWWGADMDPVTMVDVLIATGFSVDYTAHIAFKFYKVEGSNHQRIKQALQEMSGPMLQAGISTVLCMLPLIFVPTYAILAFAKTVFLVVALGLIHGIFILPVLLTTLSYRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Y9</accession>
    <name>A0A0N4U2Y9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5430</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat THOC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Y9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Y9"/>
    <dbReference type="WBParaSite" id="DME_0000107001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000107001-mRNA-1"/>
        <property type="gene ID" value="DME_0000107001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273067at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000347">
        <property type="term" value="C:THO complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042626">
        <property type="entry name" value="THOC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44411">
        <property type="entry name" value="THO COMPLEX SUBUNIT 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44411:SF1">
        <property type="entry name" value="THO COMPLEX SUBUNIT 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000107001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37871" checksum="5C20555667AA8ACE" modified="2016-06-08" version="2">MVSEHRQDFYMRIYRQKDIFSGNWLLCSDSRSRLLIFSITDALSPRDWPDSQRPLHSVISVKQPIYALESTDSLLICGDITGCLFAYFWSDLLNPSDCDAKAIFNFKHFTSSMNSDCNEINSLLIIGDNKLLFAGAADNAIRIVDIERPDQAIAVFSGHSNTINELAKRTENEFLSASEDGTVRLWDIRSQDTAHIIRVCDEPQLTRNNCGKGVCALDANSSFMICGGDVDLAIWHLSSLSFASKLEGNWPSLMRHLTVKMDGERILAGGISCYLNQFDYSGKFKTSIKTSAEAIYSIESNEIEKNAVTSSAGDSPLIDIFLNSGYISFSFNCSVVNKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U329</accession>
    <name>A0A0N4U329_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHR-BD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5478</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U329"/>
    <dbReference type="STRING" id="318479.A0A0N4U329"/>
    <dbReference type="WBParaSite" id="DME_0000111801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000111801-mRNA-1"/>
        <property type="gene ID" value="DME_0000111801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="1">
        <location>
            <begin position="829"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000111801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2260" mass="258050" checksum="A51D77A1ED4B5038" modified="2016-06-08" version="2">CYPYFQFTGIDDQPFTINISASSFSLSDSTQFYSELYKERVVIKWFPDLSIDSSNGKSSRINIFFQKYTSVDLDLRRDWDVHFVLQVPVQMNLIIDGQRQRIKLDIIIECSSVLIFPLNQFSNNCIVAETTNIRATNQFKFSSFIKYFEQYNLENQDENDDLFNCLIDWLTIKFSDVRLYEGFRVEISKVQDVQGYESICQFLSQSYCFFKSKVNVFSQSHDLEFDCFRNLDAAISHSVPNLAVVSTFNDMNLMLTADFYCLCRGFLQLNLGDQIITIPETVPVEVLLKPIDSCFDCLVRSSYGVTSFVPFACIRLNRSRFFFNNFVDNQSEMDLICENYELHDTRIKYLNDGKLSSVFPIVLCSKTPNDVNRNFMSEAHLMMKKDETPVLTLVLMNARVLLFLDWFAEAKNFILLNTDFVPPGKFLIFIALETLIDDVKQDCLFVNSGIIQRNQPCATTNIHEQTIMMKITVKESDLVLLEAPESSNSLALIAHITAVLNISDPHGFFGANLEIQRLNIDWCTMADNNIRCQLTNDFSITISLLPESDNLEAEYVSDFLSGLPNFTAAKHHLIMEIKDLVTRASFRDVAVIHRVFHSSIQRLTASQMKNNVSNAVSEMKGRDTINIIHISVKSEMISFWLLDDSLGTVFPIVRFVAKNFNLEYKLKEVSASFIFSSDYFNQRVFGWEPLIEPWHVGKLSATTNNRSEISINLHAEDKSILNVNITQVFLSQALEFRSRWLQIKDSLNNEFRDIYLRSRSDYLPYLLRNEVGSNLKFTIDVEEVIKSRLNHRKSNAIWISVAAGGTCAFEFPTKRLALMDCPDEPRQMIIRIEGWDEVSPVSVDAVGTYFRLARCSSLKAPCLANARLVIVVNMDKNGRKVVIIRSALTIISYLANPVLVMVGYVRGSVDNASSTFRIATREKFHVPLKFANSHIAFKPDGCDIIKSLKIDWQEAKNMGEYVNNFLKFESSMHKYYWVCVSIKREHFPDYEHLSGHTISLMPPLTLLNLFPIDLEFNVAGITYAVAAGKQLYITDIDISCDIWFSLTTERFISVETTLVTRSVLSYKPSSSDPYRLHLRMRDIAGRFLDAFASISVGCSGAVSISFWVPYWIVNKSGIPLILKQDATNEIAAGQLDEHERAKDRHPLMFSFADDNCPQQCVVRLGNEFTKNKGYRAIYSRKFILTLGVHALKLYLTHDHEPSLIYNIGVEIRQGTGRYKDTQVVLFTPRYILCNETSYSLFASHVDVAEQRKHCVKIASKCNLIWNENFEDNRLLCIKQEDIKYWSCPFRIDQINSFHLTMRDSEEIPRFLRVEIILSSSVFYITFTDAKYFPPPIQIENLSDVPILYNQMTERPDRGHLRTICKARSIVDYAWDNLYAPKLLTLQVFENKSHSYDPQKIGMGPPLVYDNDVYIKLVHSFDKNIGNGFTDEQELVLETMKKGKVILNKINLSDSSCSQLWRFTKDGCLENIAMNNRAKPGERYVLDVLEKGGFVLMVVKRNSARDRFQKWHLTPDCRLRCKIDGMFVEARCTDLILAPANSNSPRNYDGIPKEQVWQLQPQRPGSGVLDVECLHRGPTLVTIVLRIRDRKKLDAKSLGSRVPRISEIQRNASNDLSFLNIFNLEMNISLPSGIGLSLINGQREELIYARFHDIVLHGIRRNGTYQITGHVGVIQVLIMKIMILQVDNQLLATDRWQLLYCFSATMAPRTSLFDPYINRPAVKIEMSCTPLEHYDAFDVLRFQCLRIRLCDITAQLDETLLWKLVQFVQGKVLSFFLIFKYIFMKLSLIALAESEAANSIHPSTLLQPPNIELERPDNSRARRCYFGTLDLEIGDVTLSAVTVGNSGLPAELRKLKRQFNVKLVSFENAMVVLPAFRQFRYFETFPFLIDTLRNFYLAELKNQTFNIIVTMDAFGNPLGLASDLKESFEGLLFEGDLGGFVSGLGYGVTNSISKVASSMAHGVGTLTFDEEHELMRQRILRYQYQAGSNSALAHFYSGIKAPIVTNTYTGTKREGFAGALKGITTGAVDTVTKPVQGIFDLVEGTASAFKEIVGGPSARKSYFPDNRVRLPRVCTSLQSLLPCYSDILAIAQMDLLRINNFATNEYLLDVEVFLEQRSNNEMIRQYAMICSETCYIIRQIDGEPSSVVQRIAYKLLKQMQPLNVSKMNNIASIGFPFEHRKIFVKPFRPELSYASAEANDKLIIISEIILEFSAGKRQILPHLWCGGMEIATRLCDKVTRAKHLYDHNKRTLIVAEDYEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U348</accession>
    <name>A0A0N4U348_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5500</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U348"/>
    <dbReference type="WBParaSite" id="DME_0000114001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000114001-mRNA-1"/>
        <property type="gene ID" value="DME_0000114001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877997at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000114001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19443" checksum="AA4D5394282F8B31" modified="2015-12-09" version="1">MVFPCVAPWISGRPACLLRVIGFATSDSVKTAIDKMSGKELDGEIVQVTAQKDDQENEEGHSKERGDEQLKHSSEHSRSRTNSGTSASDDDEDNAKKEADDDDEDDDDDDESGDDAVENGGESEQNGNYDNSAKTRKRRSDAGRNDGDHHVHAPDLKKKKHEVEEDDEIDSTAAVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3F4</accession>
    <name>A0A0N4U3F4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5618</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3F4"/>
    <dbReference type="WBParaSite" id="DME_0000125801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000125801-mRNA-1"/>
        <property type="gene ID" value="DME_0000125801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000125801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23858" checksum="F4E7AE12244C9AF8" modified="2015-12-09" version="1">MMLSQPTLHMQPVHSTFLHQQGGIAAQTEIYAQQTPVIINNITGINSISNSGNGEQADEWKPVESRRANRNGSKRYGFDKRGAYKGNSGRGGYRARQGGQHQSKNFMLNDGRSYVPNQRSDNQMFDHNKTTSVANSAIIGKKSEKKNDTIGSLENGGQMKHRYYRGNSRGNNGIKQNYNGYSRSGGNVPRRSRGYNYASDLQQCGFRFATDIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4D4</accession>
    <name>A0A0N4U4D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5996</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4D4"/>
    <dbReference type="STRING" id="318479.A0A0N4U4D4"/>
    <dbReference type="WBParaSite" id="DME_0000163601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000163601-mRNA-1"/>
        <property type="gene ID" value="DME_0000163601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000498">
        <property type="entry name" value="Striatin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000001">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="640"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000163601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="730" mass="81529" checksum="4041C64F0B45AEB5" modified="2015-12-09" version="1">MVNIGGTNNSPQNITSACKPNMTVKLLKVRRVPYTMHGVLHYLQHEWSRYEMERAQWDMERAELQARISFLQGERKGQENLKADLVRRIKMLEYSLKQERAKNYRLTHNGQEQPEAELTAEDNQTVLEGANQPPLDVDAYSPQYNSASTFRNARALLRQYLQEIGYSETILDVRSFRTKNLLGLIPQNDWLGSDINNDSRQAAAKATHETDRAVVEAAQFLNKKKHDGVRLGTDESDSDDEQRSRKAVKKDILDPETVDALGEFSFLKDEKVIANKKRVDNGGEWGVNQHFIDQMKEKFRLEQEKKRGSSQSDGPSAKGQHDMYCSSQDDPKREVINDEIPQICSGKARKDYMNINSALGITDDTPVDIKDDFVGSDEDTLGIRWNLKFILRSHFDSIRAMQFHPVEPVLITSSEDGTAKLWNLGNTGQKSDATKGAQAPSQATTITELEPIYTFRGHNGAVLCMDMSPTGDMCYTAGYDGVICCWSIPSVNIDIYDIYDPKVLVEKLKGHADAVWSIAYHSSDNRLVSASADGTIKLWEPGSTESLIKTFGAPSISLRPTSVDFVSTEHQQLLAAYTHSYASILDLETGRTVLSFDFEEDAGLITKILSHPTMPVTLTAGDDRKIRYFDNNTGKLIHGTVAHMQPISSLAIDPNGLYLLSGSHDGSLRLWNMEKRICLQEIPAHRKKFDSAVMSVAFHPSRPLIGSAGADGLAKVFGSQKYSYGSSSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4F4</accession>
    <name>A0A0N4U4F4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6021</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4F4"/>
    <dbReference type="STRING" id="318479.A0A0N4U4F4"/>
    <dbReference type="WBParaSite" id="DME_0000166101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000166101-mRNA-1"/>
        <property type="gene ID" value="DME_0000166101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000166101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47563" checksum="9686A889FD02C0CC" modified="2015-12-09" version="1">MRGNCNSLRPNYLGDVEAHMTVPEIINRWGYPVETHTVTTEDGYILVMHRIPHGQKESRNSSVSKPIIFLQHGLLCTSSVWIMNQPHQSAAFIFADLGFDVWMGNNRGNTYSRKHLKYSARNRQYWHFTWSEMAKYDMLAMINGVLKWTNRSHLYYVGHSQGTLTMFTKLSEDEHLNKKVKIFFALAPVGTIAHVKGLFSVLGNSMYRQFQIFSLLFGDTEFLPNNFITRLITKFICGIASKKPLCENFIFMLSGPDSHQLNKSRIGVYLSHNPAGTSTRNMWHIAQMVRHGKHSAFDYIFPALNKKFYGTSEPPTYNISTITTEMHLYYSDEDWISTGTDVRNYLLTNLPSAYLKSVNKLKDFNHNDFLWGWRAPKEIYLPIAKQIWSDYSKNNGTAEENCNKIVQLTDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U534</accession>
    <name>A0A0N4U534_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec3-PIP2_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6298</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U534"/>
    <dbReference type="STRING" id="318479.A0A0N4U534"/>
    <dbReference type="WBParaSite" id="DME_0000193801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000193801-mRNA-1"/>
        <property type="gene ID" value="DME_0000193801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14683">
        <property type="entry name" value="PH-EXOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000008">
        <property type="entry name" value="Exocyst complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000193801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20088" checksum="C71655337A57A7B6" modified="2015-12-09" version="1">MRAIVSDLQRAVFQADDERVVAVANIIRIGTKKKKKPTFICLAVTTDQPISVRLYFVKNEKEDLFKKKEQFNLRNVKIVDGINPRKYLPEFELIIGERLYRLCASSPEEKDAFIKQMYKFSSKYLPVQKPDFVNVPIPVDTPHVTVTVSEVDDDAEENLADYQVFFAFNLFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U583</accession>
    <name>A0A0N4U583_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6353</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U583"/>
    <dbReference type="STRING" id="318479.A0A0N4U583"/>
    <dbReference type="WBParaSite" id="DME_0000199301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000199301-mRNA-1"/>
        <property type="gene ID" value="DME_0000199301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799622at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="225"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="364"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="444"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="560"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="756"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="845"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1137"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000199301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1336" mass="151818" checksum="71DBFB51F8FE4903" modified="2015-12-09" version="1">IDSFCARNINFECLKKICIKFFQFHIQSHCFFIAFQLSYMQYSLLQHFCSLMRIGHWKKRCQSLYAQLNRNSKFFLMENADGTRWQSFSLVLGNSYERENLEIQIIDVNDNIPIFQPMRSYFNVSENAATGTAIGVVKTFDPDTGIGGVAKFFIEDDRFSADKSKCSRSYCTSTIRIAKPLDFESEPVINTTIVVQDGAGRTRESNEAKKPVVFLNTLSMPPVFENDVSEIIVDEKCKIGEKIFRIRAIDGDKSAQPQSRIRYSISDNNFFDIETLSGWIILKKDLNQHSTDSIKIIVKFIFIFSIQFTSILIWFKMILTPLSNSTIIGNCAISVEIVDKNDNIPKFQSSLNRLSVMENKLPHVVDADSDLFSKIVYRIVGYDSDNFTIDQNGTLFSNGIFDRENKNKYYITIEATDDSGKGLSISRELIVEIADENDNAPKFSQNDYKMEFNEESQHRFIATDADEGNNGMIKYSLVNNTHFGINIDQRSGEIQLPKFDAESMEKLNFTLKVKASDMGVVSLHSYTYIQIFIKDINDNAPIFLDRFVIVNVSCNFLGTIAQVKAFDFDRTTANNQITYIIDPLSTEFHVDPFNGNITMKKPFNNNNKTFAQIEIVAKDNGVPQLYSKAQLFVHFKESVIHLKEPHARVEIFENATTGTTVYEPVVINPSSKMEFIMDELINVTWTRQPGKQWKWLNIDRHNGSIYLEQMIDGDMVDQLDISFVVIDKEKSTSGRGNIKEFFIMDIIGSFIIGQLTAILNVKAIDLDKSDHIRYSLVAIDGIDGYLSINNEGDIALATKLDYKSVYLITSTVLAKDEIGNVAAANVSIFIMDINSNTRPLPEFRPSSIFEAYVEESAPVGTKLNLSYPMAYIGDSRTYGQIKYSLVRGIKFFAINSLTSEISLKKQIDFEQQKIHSLIVKASVFSRIGNITEAFASVKIYVLDVNDNPPRFFPSELPLLMVAEDKPIGSTIIKLNATDLDSGKNGEVSFYSSTSDLFTLSISGVVTLSSPLFGKARKKSCFTVVARDHGLPHLQTSADLCILIVQAEMIGDDLYILWPEDSSIHYFDEVSYRLFNFNKIFNFEEQKLFELKIKICISNRCTQLNIFIAINDLNDFCPEFKQNVGTDGNEVLVGTFPSAVDMDGSKNHRSICYKLNESGTFFLRNISSNNIFTRESFDRERIARYNITVMAFDCKKSCKDSRKSVQNRIILIIDVEDVNDNFPRFQRRIFHSGIIQGHVRPGDKIMEVRADDADTESNGLIYEIKGIMKKNDQVRIRSFVYKRPFELNSSTGEIYSNSYLETGESTSFSFYVTVIDNAHHEDEALVTVSFLFIFSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5D3</accession>
    <name>A0A0N4U5D3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6410</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPRBP/DCAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5D3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5D3"/>
    <dbReference type="WBParaSite" id="DME_0000205001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000205001-mRNA-1"/>
        <property type="gene ID" value="DME_0000205001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871922at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000205001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="934" mass="107054" checksum="43D8EDCCDD4FE6E0" modified="2015-12-09" version="1">MSGIFGLQKSGHGTLQALNENQINLVNQLQAVLSVWQVEYVDSNFDPIDTLNGLAELVEKSREEYLRQDPDPLDHRHPIKTSPSCTYGHMLKILARNTEFINKLCLSYLLARDNTSLNISAARLLLSCMKGVDATSIFTEAVMPQLYRWAERSDTDSILRSMSYALLAYALESTDIASKYKAENAVLIPVALRLLKEYFMYSFNFISVSRMPQISGTNPFDNDLSNGVEKLESPPRKKARLTASLVSLADDLSNSQWTELQKRKVGNCQIYPITTLMHQKLILKYLISLGEYQDLLKEAYENRSLEIICTYLEDANKEDVRLTFFVLRYLASLLVHRKFAMDFVAAHGVEKLIRVDQQSFACVAVGTCLYYLAYNYDVLEQMNLLSESVLDKIVKFQLWMLEHSHESGRGAATMFFAYSFQLRAILERFDNNDGSRRLLNYISTLTLLQAEERSSLPEELLFTSFQAVRNTCAAFRRFIFLDIFSCPSNHYNCCCFKVLKSLLLKTSPITEADAIRTLVCQILNGLARCEEVRQILSEMPLIADNVLLGLMREPVLPDKRAEHLRFCEQARLLIEREKIWKSAIISRTKINFNEKELLQLIHQHLCKKGLKKTAEQLQIEAELPDVPASLFTEAPVNLWFFLSNNFRKQHAMCNNPISNCPPFSVFLSFISSFIFFQIDSLMNSYESRKADERFVFSRLRPIKTFSETDETFTCCSFSIDDEHVVLGTYAGSLHWYNVNTGVEESLTECHHSAITVIEQSRDGSLLLTSSSFVKPLSSLWKIGETQDHKFNFVDDYYVEFSKAYQNRIIGTRESTATVKNFSNKFLFISKYYFRATFHPLDNLVLNDGVLWDIRCASQALHKFDKLNMVISGVFHPHGNEVIINTEVWDVRMYHLLHSVPTLDRCKIVFNRTGNILCAGNKILFTCGFSSKFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5E9</accession>
    <name>A0A0N4U5E9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6428</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5E9"/>
    <dbReference type="WBParaSite" id="DME_0000206801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000206801-mRNA-1"/>
        <property type="gene ID" value="DME_0000206801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000206801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19084" checksum="891014793EF94587" modified="2015-12-09" version="1">MEDHIEESLSEKIRRMSRTNKWEEFDSEDSGNRKIWKCQPRTRSEKPPCPKSGSDIETRGKTAQSDSLVGPKNYVSYHDPEQSAHCITVIKVQTNDIGTCGVLHQQKPNLSVHFIGPFTQFRANQSRNSQLENAEAVHFTEDRLQYSLEEEEKPFSATFFPPSGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P4</accession>
    <name>A0A0N4U5P4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6540</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P4"/>
    <dbReference type="WBParaSite" id="DME_0000218001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000218001-mRNA-1"/>
        <property type="gene ID" value="DME_0000218001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="11">
        <location>
            <begin position="130"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="327"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000218001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53993" checksum="F2DD69A888022EE5" modified="2015-12-09" version="1">MDEKLAIIYEDSDDGEFLNWKVCNGSYIRKNAHLLNYSKLKKICHKTFKKGFLLKYGMTVATIEPCKHEIVMKDMCATCGKDFRAAHGSVTGILNEAPAASVSMIHHVPELIVSSQLAREIGNRDREFVLKARKLVLLVDLDQTLIHSTSCPFSGDNVSDIKCYKLQSTTFYTKIRPYTREFLERMNILFEMHIISYGERLYAHQIASILDPDKIYFGHRILSRDELFCAMYKTRNMQSLFPCGDQLIAIIDDRPDVWQYSDALIQVVLIAFSLVMACSVIGNSDETDHTLEYVADILTKIHREFYYHYDKDGGKVITDLKTIIANERAKVLKNCSVVLSGIVPVGTDLTKVEAYRLCKQFGATVTININDKTTHIIAARWGTIKVHEALKRSDIYVVHPQWLYDCVERWQKIDEKDYLLTKETMNKTGKPLGGSLIKGVLPTLSTLNSMLKEVEEEVIKGHNFRYFEIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6D8</accession>
    <name>A0A0N4U6D8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-hexosaminidase</fullName>
            <ecNumber evidence="8">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6840</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6D8"/>
    <dbReference type="STRING" id="318479.A0A0N4U6D8"/>
    <dbReference type="WBParaSite" id="DME_0000248001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000248001-mRNA-1"/>
        <property type="gene ID" value="DME_0000248001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229822" description="Beta-hexosaminidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="12">
        <location>
            <begin position="191"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="299"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000248001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="560" mass="64699" checksum="3D078432E537521E" modified="2015-12-09" version="1">MKLNPIAQYFLVLLLLIDVHAQWPDPSKKTHGAIWPLPQEIQNSSKTWSIDPESFKIESDYQCDIITEAIKRYTKRLFPMREKCSLSSKQDTAVKKPFTNCYVMDLDKELEEQSKLVALKIIIQIACPSGVPTSNMDESYKLDVTWKEAILRANEVWGALRGLESFSHMVYCDKTSGYQIRAEIVKDFPRFPHRGVLLDTSRHFLSVNALKGNIDLMAQNKFNVFHWHMTDTESCPYSSRVLPKLDHGAYDDKHKYTIEEITDVIAYARLRGIRVIPEFDSPAHVGSWGKGYPNILAKCYAEGFIIDSFKSSILDPTKDETWDFLETLFQEVYEVFPDDFMHIGGDEADFWSGPCWKENKNISDFMALYELNTTLQLQGWYLNKLRMMMDGIGRKKYIYWQEVFESGAQLTDSIIQVWKGRSNIEIMAYMHEITAKGISVLLSSCWYLDRIESLYDWFSFYQCDPQAFNASEMQKKLVLGGEAALWGEWVDETNVVARLWPRASAVAERLWSPSKSTQFVSEAWPRLFEMQCRMASRGYPAQPGYGPGFCDTEYHITLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6F5</accession>
    <name>A0A0N4U6F5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6857</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6F5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6F5"/>
    <dbReference type="WBParaSite" id="DME_0000249701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249701-mRNA-1"/>
        <property type="gene ID" value="DME_0000249701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20982" checksum="6A032E16345F40AF" modified="2015-12-09" version="1">MDNEELLMNVSGEIKFSSFKLQILNRKSFWTEKHYLADIRLLISTIAVFFSAFAFIYDYLEPFPKSKPVLATCSITYFILMGILQLYMWYVEKGTFFQAVEEDYQKRHPKRYWKWSSSIKKFDDKYTLEAEYTQESLSGQTKVIKSIGCFIDEDGYVVMPLLEKEVEHLINNVLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6U2</accession>
    <name>A0A0N4U6U2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7026</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6U2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6U2"/>
    <dbReference type="WBParaSite" id="DME_0000266601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000266601-mRNA-1"/>
        <property type="gene ID" value="DME_0000266601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000266601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="51284" checksum="D66216CCF5374270" modified="2015-12-09" version="1">MPARINFLSKRLIIIIYLLTIVLEKLGYRILYGPNETNFDLLWVHEYPFTIASLQRFIKGVRPYQKINHIPGSGYYTSKIHLLTSKLSMGLLKTFKIPEMKDEFLRYYERNSNELFIIKNNKHRGIEIKSIDEINFTINNFFIQQYVSNPYLIDGKKFDIGIYTVITSVLPLRVYIYEGDVLLRFCPENYFPFDSKNKDKYVVSDDYLPIWQVIYQLKKYYAEQKMTSRETLNAYIRANGKDASKVWSTIKEIIAEYCANFRPFFELSRFDFILDDHLNQNGLLPDNLFLANMSPNLSSSHFKQNGLLYEQLLLNVFSLVGIANHFHGQSLEEKLYVFFYWCPLYFCAMLKYKLRIHLQKCRLCGHCFNYEMKTILRSSYLEQISRRNLRRVLPTTIPNERHVYRKYTQLDRLIILWFDAKCKQDKVWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6U6</accession>
    <name>A0A0N4U6U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7031</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6U6"/>
    <dbReference type="STRING" id="318479.A0A0N4U6U6"/>
    <dbReference type="WBParaSite" id="DME_0000267101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000267101-mRNA-1"/>
        <property type="gene ID" value="DME_0000267101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9894375at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000267101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35753" checksum="ABCFC69C928D093A" modified="2015-12-09" version="1">MSNITQLLLKDEQNFIDVAKLTFYASTTITLESAFALFINLYLLSCSHYLRKPIKMNLRLCINLTAANAACAFFYMISNLINVIIPTINGNNQIVSHCISLLVECLKISMFFASLFILLALAINHYVGIIYPFYRILLFLAYIVPILFFISLYSIMPGGFRNKEAFGFLTLKGCVGANIMSKFFVRLITVIPFILFVAIIVSLYIHIVIHMKKVISMGNFIHVMKLIIDAFIYASRLVEIRYSTWIFKIKLKSLLTGKRQNEDVLPNEFTKYVNETIENNENHRNIYTREANPLTGRKSFIGDIKEAPNCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7C3</accession>
    <name>A0A0N4U7C3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS110</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7C3"/>
    <dbReference type="STRING" id="318479.A0A0N4U7C3"/>
    <dbReference type="WBParaSite" id="DME_0000288101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000288101-mRNA-1"/>
        <property type="gene ID" value="DME_0000288101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10350297at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000288101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60858" checksum="A97245155D6B34F0" modified="2015-12-09" version="1">MRSARIRTSRFVGRQCQTLRWSFARHFAVKQTYAATCTAIISAGHMQQHAPPLFPQDICSNINMQTYAATCTAIISAGHMQQHAPPLFPQDICSNMHRHHFRRTYAAILTCRHMQQHAPPLFPQDICSNMHRHHFRRTYAAILTCSINDIHLAYTIIDIYLRLRASHASNAIIVELKLVDNTVFEFVPSLLFSVYSLYSRSKNRRLYFYLILNAIDVSFELIRQFLESMRPFASWLETTIEQILWVDVPFSIEIGGIIADNIFLSRIKSAEDLVRRIHHMAKIYMRMHQDLKNIELSSNNFSSLDVDQIKDLIAKLENQWSIVINEPEGLNLLEDGRLICEQLVKQYPMLEELDSFLYVDIVDQTIRAYKELSSVIPNIESAKSRKLRSLLVAIDAVEFLEIVLKKSHSFEKTLKELERMKNVKSFNAARLSTQLKKIEERAAEEDIQLNEALDYLDNTKDLLEEYSISDSNREILKNARKSLEDIVGTTKERIEDVRKSIQNALECRRLVDQVLFMKLYVKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7C7</accession>
    <name>A0A0N4U7C7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cathepsin L-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS114</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7C7"/>
    <dbReference type="STRING" id="318479.A0A0N4U7C7"/>
    <dbReference type="WBParaSite" id="DME_0000288501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000288501-mRNA-1"/>
        <property type="gene ID" value="DME_0000288501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="101"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000288501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35731" checksum="7403702762D4B001" modified="2015-12-09" version="1">MSLNVFADFIVASNLEWERFKNIHKRIYGNDEEIKRKIIFMKNLRKIYEHNERYERGEESFKLAFNHLMDLTDEEYGAMNGYRKEGKMVGKTFLRPYNAQIPEKIDWRKEGFVTPVKDQGDCGSCWAFSATGALEGQHKRKTGKLVPLSQQNLIDCSKSNNGCNGGLMDDAFQYIEINKGIDTEESYQYEAKDGECRFKKDHVGATDAGFFDIKSGDEEALMEAIATVGPISVAIDASDPKLKLYGGGIFKSDKCDSQKLSHALLAVGYDKDPKHGEYWIVKNSWGTEWGIDGYLHIARNHSNMCGIASLASYPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D8</accession>
    <name>A0A0N4U7D8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS126</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4U7D8"/>
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        <property type="protein sequence ID" value="DME_0000289701-mRNA-1"/>
        <property type="gene ID" value="DME_0000289701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876908at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="568"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="831"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000289701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="831" mass="94516" checksum="AA4F59150A191799" modified="2015-12-09" version="1">MSFFSSSTEGNIEEISSSDHSCKIPTPDIFEFTSDSNRDEHFRRSPSRTVLSDLHSVNLQISTSTPVATNVEEADKEMRKFRCVLKGVKAFIDTERKSAHGYRLKLRKLGALVYCRITKTVTHVIFWNGKQRTLDLAQQMNPRPFIISYHWILKQCMLGVFHIIFRCFEQRKHVSENPYLLYGLTDLAVPLEEMALGRIGIMKKDSKGISAKNIKKRKKFGTRNPLKSNLTEHFLFFLQIFSIGADILNEIRLVKRLNCKFIEVKQNELCVNEIPPCSQILYSMEKLSDQLALRITSPESDQIVSPDQIISPILARFKMRCMELYKSSVRFARDFPRKSVDAATNTTPEHVDLFESSADDRFSNFSNEIPSAKISTFLRKSAKNSKSILNLTSMRTPVDHLSTNEITATLNQMVLDPSVVRQTSGKNVADLSRSSVSEKRKKSGRPPITSGELLEFGPDDFNKHILRRGSTKVKQAIRMNAKQAVDVYRSIFDKTQSEPEVVPKARPVTVRTKSKILNDLQIMPSSEEFVRFRHKKAARKIGNIVLSKLEKILETSMLLVPLAVGDLDSECFLDSFKIFSKPHIPTLSEYETVVAIVKRLGVLTVMKEVDQQTRYVVCDTMGSITNSVLDALVACIPIVTSEWAYRSLEMGGWLNGVEYLVSKWKKSFKIRKKGHPPRLFAKLGCFFISVHCDLAISESLNRASIVIAPNSDWHLYANRRLLDGSSLSVVSERWIFVYVGVCVHSRRHHDDGGDGDCDGGDDGDDRRGRGHGRRRGRVRGDGGGDGRGHGRRRVHGRRHGRRRVHGRGRGRDRHRDRQGRPHLRKHQFHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7N7</accession>
    <name>A0A0N4U7N7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Velvet domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7166</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7N7"/>
    <dbReference type="WBParaSite" id="DME_0000300701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000300701-mRNA-1"/>
        <property type="gene ID" value="DME_0000300701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000300701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9971" checksum="C6DB6308808E463C" modified="2015-12-09" version="1">MVPEKKRVRFDFSPLLNGTDECSEEIGYYQMTAVVHYHNRPTHSKSILSSSRTFPVCKCRMTDSMSQDFDHDPNSPKQVSLSFFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8U3</accession>
    <name>A0A0N4U8U3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SRP40_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS346</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8U3"/>
    <dbReference type="STRING" id="318479.A0A0N4U8U3"/>
    <dbReference type="WBParaSite" id="DME_0000348001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000348001-mRNA-1"/>
        <property type="gene ID" value="DME_0000348001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="861"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="873"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
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            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
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            <begin position="444"/>
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        </location>
    </feature>
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        <location>
            <begin position="485"/>
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        </location>
    </feature>
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        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
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        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
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        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
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        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
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        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
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        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000348001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="958" mass="104903" checksum="447244E492E43F42" modified="2015-12-09" version="1">MNDSTEVDFELLFYDHIAKKEPRALNRFYSAKRRSELEEKRRSSGHFKSLTEVVEDYNRIIRRKRPAGEETCDLPVKKNLKQGERSDSDSTTTSEDDTSPAKVALNKRPEMGENVIKKMDKNSSSDSFSDDSVKRELLGIIKETGGNIEMLKSLLYALENPSYDSCSSGSDSKIEEKKSVPISVSNDRENLQKGKTVSAAKTFKTCKSSSSSSDSDSDSEEKSTVVKNGFKKTQTMSVSATKFSGILSKKSSSSDSDSASSDDESQKVQTFISKSAAHTAVKLSHSAGKSTSDSDSSSDSGNSDQTVTQLKKGEDNSKARRTSSANAVVVKKNTGAKSSSSDSDSSEIHSSNTRSGYKKTTKVAKKSDSSSSDSDSNSEVVQHEKVRFNNVEDESKKPVANTKKSDSSSSDSDSSTENTKPKGKSVSSKMMVKSVISNAKKPVKSISDSSNSSSGSGNVQSKNVQFSDSKIRSKNYVELGKKFDSSSTDSETTTEGMQFKRKQSALSKPMVKSVALSAKKSSKKKSDSSVNSNDIDNIQSKKVEPNSLENGSKTPVQSSKKFDSSSSDSDSSIEGMQIKKLQPNNAKNEPKKSAQFIKKSNSSSSYSNSSIETIQHKGKQSVPAKMMVKSVTSNAKKLSRKETSSDSSDSSSDSINNQIQKETVKSFVQNKFAPISHSKSKSQKAQNSSDSRDSNDNNSAKKSIKTNAEVHKTSTIAAKGKNGSSSDSSSESDNKQRAALQMKQWYTTSKIRVQDKQKNSTSSSESSDSSNNNESEKKRSDSTNITNKSSSENNFLKKEFATKMDTSKKTSEKKKISEKSISSSESSVVDSETEGKNNNNQSINTSQKHKENEKIKEKKEPYRRVTNSKEELSEKFKDNSFRGKVVLCFMLLNTGILPSSRVSIFQGYDQWGKKAYEAFKNVQGKGFRHQKLKKKRGTYSGGEINREIHSIRFDSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U918</accession>
    <name>A0A0N4U918_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7564</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U918"/>
    <dbReference type="STRING" id="318479.A0A0N4U918"/>
    <dbReference type="WBParaSite" id="DME_0000355901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000355901-mRNA-1"/>
        <property type="gene ID" value="DME_0000355901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2570713at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="161"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000355901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35690" checksum="8ECAFBDCF39BFED3" modified="2015-12-09" version="1">MNNWYEIFIENNHIITKNRSRNFRKFTATEDVSYSSHTSRSSFRSESVTQKTNHCGRSTSSEIISSSETRSLPVYIAIHDYTPEPNDSDSVALEQGQIVEVLDKKNASSWLIRTKARPPKSGWVPGCFFETPTEYYKQRRRTREISEAEMNMSEEQQAIMKRDQVYHDLLRSEEEFVEGLRHVVDNYIRTFEDEWVPQQIKKIKEDLASNIKELYNFHAKYVVQEFGKSAKFLGFAPMTRLTLVSNNIGGVLLKGLQYYSDDPGKVGQTFIRLEKDFDHHVYFHEKMPSLLKCLADATVNEFIQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U968</accession>
    <name>A0A0N4U968_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7619</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U968"/>
    <dbReference type="WBParaSite" id="DME_0000361401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000361401-mRNA-1"/>
        <property type="gene ID" value="DME_0000361401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041628" evidence="2">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000361401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29941" checksum="B123C82CD29C058A" modified="2015-12-09" version="1">MLSSILVVLFASSASAQENICIECASINLKNRWPLTGFSQILRDGSFSTTCASGADTDHSVRCTGPCMTYIFEDPDIEGDSTNKYSESLAVRSYCEYDRDFPRPNSQGKIVFIKMLVDFCEGNSCNSKIKDFQDSAQCLSQVPQCKFIFKIVMVLPIAPIECYFCESDGENCHYAHEQCYKRYCYKSIFDIKGTQSTRKTCADFNPFGMHSGCSTSLVQLVPGNSLKVTGTITQCFCNDKKYCNGTAGISTINLLLYIFITLIICAFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U972</accession>
    <name>A0A0N4U972_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7625</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U972"/>
    <dbReference type="STRING" id="318479.A0A0N4U972"/>
    <dbReference type="WBParaSite" id="DME_0000362001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000362001-mRNA-1"/>
        <property type="gene ID" value="DME_0000362001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000362001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42389" checksum="D5CBBB5970F1E4D1" modified="2015-12-09" version="1">MVQESTMICLDNSEWMRNGDFTPTRLQCQQDAANLVIQCKLRSNPENAVGIISMANTVEVLSTLTQENGRLFMKLHQVEPKGESNVIGGIKIAHLALKHRQNRNHKMRIVVFIGSPVNCIDRNELAKLSKKLKKEKVVVDIICFGEADGDSNDIFGQFIESLNSREGGGSNLIVVSSGSTLTEALVSSSVCRGEDGTAAPVVAASGGGFEFGIDPEDDPDLALACISHYYALRVSLEEQRQRQMQEANAELAGADSIRQQADVNDDFMNMDPEAMTEDQQLAWALRMSMQEGPSAKSSEPAEKAKTAGVSDKITIANEMEIDQIPEEKEVTAEEDQLGQLIDDPELLRQLVADLPGMDQGSPEIQNVLQKGAASNRDEKTDPVDKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9B0</accession>
    <name>A0A0N4U9B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7666</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9B0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9B0"/>
    <dbReference type="WBParaSite" id="DME_0000366101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000366101-mRNA-1"/>
        <property type="gene ID" value="DME_0000366101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000366101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28555" checksum="A8F707C8C60AE2A6" modified="2015-12-09" version="1">MSSPLVENVQQRLCADMCTVCGDKSTDKECIITSKTRNCCQYCRLQKCFRVGMKIEAIRAERNQKKREKEQIREKNFLAVSDIENLIENLVKSYDNAFPSDVSISSVGHAKSLFKLFLSDSSLFEPAQNSIINACIESSFLLALLVRESFNRTDFGAQFLKNYDAEIERIRGRFAAMLQKDVEVLLTILSLIITNTSISSGFLYGISGKLTSCLMLIMHRISADGADIFSEVITFLLNLSERITSLRTADNSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9H4</accession>
    <name>A0A0N4U9H4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7748</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9H4"/>
    <dbReference type="WBParaSite" id="DME_0000374301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000374301-mRNA-1"/>
        <property type="gene ID" value="DME_0000374301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000374301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1552" mass="174363" checksum="08C38AC3DE3D61B3" modified="2016-06-08" version="2">MKSFVDSQSSPPQYHIKRDRSEDVYILQEMTKCHVSLGDEAKDFDLAIEPGENRFTFFAATQQNGEFVPYEYHFMIYGYCILKEASAEYIATRGKFDSARKKFIPGKKYKSGTQFVIGINFTYEEGDKCGGEWIQEKNNEIILKKICSEIANTELNKYIIENTFFNSNYEHFGRNACVRKIKKIPYEIKFENLPSIEPFVTHDDALLAINLQQAGTYEVTITNLIYKEEFGIDLPIRLKPVTICSDLFAENDICYLSTKKRDADQKTTMQSTHLKTTVNTRGLKTTTNAKRTKKTTANEALNTKAIEATMEATTPAKINNAVSLQPNIKTLATMEVTETKISNTPMKIIDLAKAMDFTGLKTIVQKSSDPAIITKGMSPEKSIRISGLNETNGLKMFTKISDPAKITKFTGLKKTLKTSDRRKFAETVPFGAAKVNSLKTSIKTLNMKNTVIKKANQSIKKSIETTAPKEIIKIAKIARMKNKDLKMTTIAKILKTTMKNILTKINLIKTLQKKLGKPNLIFPTTSKESGRINAKKPVAEFTTDIPEKAVADLFEIATTTLFNKSITPISQDSSGFRSTKAKAMDSFLTATKKTEVMKFTDYETIFTIISKTLKDKRRIKSDVSESSTLRLRKDQNLLETLTNPPQVDAIITEKENFVASSQRKKSGEAHFTTTTLLESSLGIGKVPPFYVNTLEVLVPNMHRNLTSMGINRLLSTPLAGDRSIANNHLHMFTISSKSDEPLLLFNESTGNFLMNEVLNGISSRKHNFLLRSADFKTEPIELITFYKKFSTILDKKNKYMKAIIDREESKNIHTAIATDLTESHPLINVFLTNKTSKTLKTYDNTLQAASRSSYSIELMSKSVPSIIQPTIHVSPQNTSIQSDFTNIKNLSLVSIFKTKTEKMNTLSSKKSEEFAKRSIIYEFLSPYIQTKESAKFYTEKMILSQNDESKLSEEVKQPSVKGFLDLQHSISMKTTDHPVIQSKIVSKSAKNEKVSEFHGSLVSSTINDSKYLLTISHHFLPPYFWNFSNQRSIQFSNVTQTSVESGRPKQIEISNESVRSVDLQGSAIDLQFTMYSSDELEEILSFRFETTVQTNKLGASDGGTYKIHEYIENNLPPEGGTCKAIIEVIYGNFNVFASCNGWMDQDGILSYQFYRSEMDNGTLIYITESESSLADFKIPLGEFEIFSVISDTLMCSTKPILIGTTVEIGTETDPMIYSAMKVSNEISGSVIHSSKFPETIQSTSSIEIYQMINNTNIIENVLSNLNSSLGKMKIEFRTILGFNNSETEAFADSILTGNLETGDLSRDEFISSINSIKIAQNEKKAKIIEQDIESLSKDKIKDKKSLVHLLGYLDNILSNAFDTTLVQEDEPNNKIEGNFQAKFGLIESAEHTLSVINGVVTIKAGETILTGDVRPAYTMKNSSDEFRIHSEKMGFASASAKLSNGFSFDTASNIFETQCLAKDIAISFHFHGTTNIMENSTEWTDQKITAWNFTYHELAETQNVKKATFTSWIELKSGKCALILDAINLNRFVSVVVTEKRVIKVKPKWLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9K0</accession>
    <name>A0A0N4U9K0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLCXc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7776</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9K0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9K0"/>
    <dbReference type="WBParaSite" id="DME_0000377101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000377101-mRNA-1"/>
        <property type="gene ID" value="DME_0000377101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000377101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37707" checksum="7BBB76408281137D" modified="2015-12-09" version="1">MYLPSDSDLAPQISAFLVYQLANFISVWSRMGPRCSHDSFANLLYTNHPVANDEGRLLRAVGRIKIIRYFIRKWAITQSVSVIEQLKAGIRYFDVRLSIPDCHTSLTGIHVLHALYGRQLSYILFEINRFLMSHKKEVIILDFNHFYNFDFVSFKEFIKLIENSFALKTLTPRCPLSGLSLDFMWKYGYQIIAIIPYHYSDNQMKISWIWGPESIVSPYPNVNRLDHLFKFLEITLKNHRKTHKECFYVTQAILTAKFRDICFHPWSSLKETFSIKCTEQTVSWISSFAHPSFFNIIMCDFINYYNFCEIVAYLNYQLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBB9</accession>
    <name>A0A0N4UBB9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AMPK1_CBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8372</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBB9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBB9"/>
    <dbReference type="WBParaSite" id="DME_0000448901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000448901-mRNA-1"/>
        <property type="gene ID" value="DME_0000448901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917859at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF91">
        <property type="entry name" value="AMPK1_CBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="4">
        <location>
            <begin position="459"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="244"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000448901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="62858" checksum="8F7C9E27A8BD0DCD" modified="2015-12-09" version="1">MEGDQSDEIFDEFPSDEEDEIKKLLLTKEKELAKAEIDLIKQEEKINDLNKQIDELHKEILAKDSSLEELNNTIKEYNWQMINKDSRIGDLDSSIKYQQEGQIKYLQDDLNKCMQINSQLRLQLKQKDEEIEIQQQRLEIMKEQERESGRRLPPSESELKMLQEKLVDAHDTIRKLNHKLENANMELEIYKHQANMDEVRKISGSYMEPANSISSAFHDGNYMEELTKEAIKSSKKSFDLSAQLKESESQKKSLMEREKSLEEDLKKMSVDIWLAKERIANQDRELSELHGENGRLKGEIEHLRHQLSTRPVGEISTDKELREALERAYSERDAIREHYNKSEWFLGETKARLGEMEYRYGDAEARRINTQFELDQTRLEINRLGRELDEVRRLKDLTNVSLRDTFLIKRDPMGQREKWKLAMWLYSLLGWKEIYRNEEHSPHDINNYRRIKFEIAAGHSTQAVFLFGSFVNWECGLVCTRTDDGTMFSVSVDLPEGYYEFLFVVDGNWQTSDRYEVVWNNFGKKNNSIYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBD3</accession>
    <name>A0A0N4UBD3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8390</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBD3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBD3"/>
    <dbReference type="WBParaSite" id="DME_0000450701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000450701-mRNA-1"/>
        <property type="gene ID" value="DME_0000450701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11828">
        <property type="entry name" value="SH3_ARHGEF9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053086">
        <property type="entry name" value="RhoGEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="288"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000450701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="50067" checksum="59A2EE30557FE03B" modified="2015-12-09" version="1">MSLLTAEAIWDHVAILPDELPFASGDSITILDYSSHPELWYGSCGESTGWFPSSYVRLINGTAPERSNSLPSFPQSLRHLRKQIIEELMSTERDYVHLLQDLVEGFVFQTRKRIEMFSSDCIQRLFANIEAIRTFHCKFLRELELSLNQNLLEDSYIGAVFLRNVQYCNNRPISCAELLALNEKPHYHQFFEACRLLRGMPKLSLEGFLLTPVQRICRYPLQLAELLKATPVSHVDREPVQAATTAMKNIAAMINEKKRRLEGLQKIALWQKNVDGWRGPDLFETNSRMIRSGEVSCRCIINAEIVWHKDVLLFLFDQSIVICKKDLIRRHHYLFKDRLSLIKAKLIDCTDGRDSHLGITLKNAWKLITMGKELIFSCKDKNDKREWIEQILKRVECSPPTAEERRLVHAKSEMAPLYLKTSGRFSWKKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBF0</accession>
    <name>A0A0N4UBF0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8409</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBF0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBF0"/>
    <dbReference type="WBParaSite" id="DME_0000452601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000452601-mRNA-1"/>
        <property type="gene ID" value="DME_0000452601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536372at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD/Chitinase" evidence="1">
        <location>
            <begin position="233"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/Chitinase" evidence="1">
        <location>
            <begin position="334"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/Chitinase" evidence="1">
        <location>
            <begin position="442"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000452601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="681" mass="75671" checksum="55807FD22DFEE38F" modified="2015-12-09" version="1">MVGVKGLNCICSEGFIRSKSGDCILLSKTAEENVVPSQPSFNFSIEGPSVVQLPQNSVLLKVVFNGTQTCINCTFYWEVLEGVGFATSDTYTKPVLKLVDLREGTIRLRITLKNGTLVAFRDTLLKILPKKQGNKAPIAVIRPTRYFIGSSDDSGELEFEWKMLNGPAVLLPAMNTAIMRLDGLLIGNYTFQYVLSGLTVRDKEGATSNQNVDVIVNPKRDDPPKAHINECGDSSPISTIDVRLPRETLLLCANQSTDDYGIESYNWFRVDNFTSQLSLDYSGSTTSVLAITNLQTNEKFGPYVFRLEVKDKSGNKDSTNVSILVNKAVNQKPRPDAGGNQTIELPQNSIVLNGNVKDDGEISSYMWYQIRYKYFLLILFYGPSEAIFVNRDKSKCTVSGLIEGLYQFRFNVTDDGGLSAVDDTFVAVIRSKNEPPVAKASNITVTLPANLAILNGSSSFDDAGIVRYLWIPNDDVPACITFLGDSVSNPIAYLHGIVPGVFLFTLKVWDQSEEQNSTVVSLTVLQGDEHLNSVEMFINQAIFDMTYRLRTKLEKSLSAALVTKVFFFMKLTGTNALENSDEVIKTSVWNTVSANKAVEFLRAESNMISEFQIVSINTLCKMRVSTRILENHRNLIKLNFSDCFLDCSGHGVCSNFTKECLCNRYWMSNIIAYLINGTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBG8</accession>
    <name>A0A0N4UBG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8429</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBG8"/>
    <dbReference type="STRING" id="318479.A0A0N4UBG8"/>
    <dbReference type="WBParaSite" id="DME_0000454601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000454601-mRNA-1"/>
        <property type="gene ID" value="DME_0000454601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000458">
        <property type="entry name" value="E2F-like (Mammalian transcription factor)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="10">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000454601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="66399" checksum="81950B9D0F1DC61C" modified="2015-12-09" version="1">MNQSSKKHRVSEPVNTIKHENNSMEASVPSFVMNFGSGVCAPEPFPCSSFFNVSLDDANNNNISNNRAAFQTSVEVLSSSGNYFAMNSAKINPSDHDASTSLNAAQFSERPPKRRQRKRYADSQAELETMIWSETDFHRSAIVSGPLASTCASDLFQNFSALPVRSTASDETKNQTRGKPRKRMVADTSHCYNQNSQVETSSNKPATPQPSLSRAENSLLVLTQKFVDLAASSGGRIDLNAAADTLEVKKRRLYDITNVLEGINLVRKVEKNSVVFTDIYGKNKADAEIQFLREEAQKMKEAEKLLDFLIKETSNSLALAKQDPTATGYGYLTYNQLNAVEKFYGKTLIALQAKPGSFTNIEVQSDDPKKVHVSSSDGSEIRAFLGPTSNGECKGEFNGNEEGTEHKNISISYVENSMRMDFMKSEISQFSFSEKCDQALIDQNHFQGLNTHSDESCHYNSQNYSGTVPQQNISFESSASSSQESHAAEGISEVYGRRILKNLEKMLMFETFLKHIAVFKGCGINRLFMSLDSPLGFPNHSFSSPLSVVTNNLSFTPFPNDVLEGNSGMLELEPTGEGEPYAYGMTSNEGLSDLYSTTDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBK4</accession>
    <name>A0A0N4UBK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8471</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBK4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBK4"/>
    <dbReference type="WBParaSite" id="DME_0000458801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000458801-mRNA-1"/>
        <property type="gene ID" value="DME_0000458801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF7">
        <property type="entry name" value="MYOSIN TAIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6" id="KW-0518">Myosin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="11">
        <location>
            <begin position="8"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="722"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="270"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000458801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="760" mass="88683" checksum="B770F289296B1C53" modified="2015-12-09" version="1">MKHGEQVVSLNQELSILIQQKQQAEKSRDILQAELEKTKVIANENKDARSEAERRRKSAENDLSAQLEIQNKSRQLEETEAMATNFQGIITDLNLQLSEARELMNFEKDEKIAVQTKLKAVETQLENALCEIEEYEKNKMKLEKDIASFNQKLINVRKKYDNSLMEQAEEIRRKWQNELNIIKMRLESSENVCSRAEKAKKKLTQENEDAMNELSTLRSYCSELEAKQRKFDQQLAEEKSLICKAYLERDQISLEVRERDTKILTLGKEIMLLQEKLEAEERSRIDLQLEIDHLTSAKDDSGKNLLEMERAKRTLELELLNARDEITDLEDALQKSEDDRLRLEVNLQSVKADLNRIAARKECDDDEKNSTMQRRLRDLEGELVSERQSKANLIQQKKKMQFELSEITEMKEQISFEKDEISRQLRKSIKLQKDLQKEVEQLQASKEAAFLTSKQLHKKLQIAENEISLLNETNVQLKNEKRLIEHEYDELKELLKGKENSNQEERKRLASRIIELQDTIDEEQNKNDIANDTLRRTQIQMETLTTELAAERLLNERLENEKNSLERKAKELDSEVTDLRSNLQVKSHAQIMQLEAKTQYLEDQLDQEIREKKATIRQVKRLDKKLNDTLELLADEKNENEKLKDSNSRTLARQRQLKERIDQLENDFMLESAKTRQLQRHLDELSEANDSLIRENIQLKSIANDARRSIIQYAGTSRFGSERSYSRGLRSNGSSSDLLRPGSASTADSEYVEETDLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBK7</accession>
    <name>A0A0N4UBK7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8474</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBK7"/>
    <dbReference type="STRING" id="318479.A0A0N4UBK7"/>
    <dbReference type="WBParaSite" id="DME_0000459101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000459101-mRNA-1"/>
        <property type="gene ID" value="DME_0000459101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000055">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000459101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29742" checksum="0802097B1D7FF9AD" modified="2015-12-09" version="1">MDIRLYLKPNCQLVLCKYPHDSQTCKLKISSFGFGQDLVRLHWFDEIDDAIKMNKKVKLPELYIVGYTKHICNGMRKSGNFSCLEARFHMKRTISYHLSHTYIPTAMCVIFSWISVWLPEEFVEGRVFLSLTVFLTLSAESGSTKEILPKVSYMKAIDIWYGFTTAFVFATMLQSLFVISLEHNGKELRKKIESNEMHIPHYKLLMLYQKAKLRSTLARMLDKYCKVLYPVIFIIFVIIYIFVITDGEENKCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBY5</accession>
    <name>A0A0N4UBY5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8627</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBY5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBY5"/>
    <dbReference type="WBParaSite" id="DME_0000474401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000474401-mRNA-1"/>
        <property type="gene ID" value="DME_0000474401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="669"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="709"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000474401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="983" mass="109769" checksum="0FD753A3195E5D55" modified="2016-06-08" version="2">MESDESESESSSNDENFEDAVDNLGSLPDILLNSSKATLCQAKRPIDASQGDFDTVRSLQLNTPHVIYANLPSSFLNTPSVAKDNATLRRGRLSILRHRMKNEFSGMIPNIFPCSVDDDAASTSDNTSLASWGRNLLMDCSSANIGPFFPADSLSTKAFSMQKSPKRHESNNFYIHKIQNHEISEQIASVSPPPPFYPPPPLPTSFHSALSKINLPPPNSIPPPLPPRRPTSLLPAVLPVSQVILQQKKNDFKKPVISCDAFARIRGHVKTKSLDRGLSLAKSMKTGPFPPPSNKSNSLKREFSTDASDPSKILALDDCEEALRNSDAQGIISQITSSILTEDPLREEKDNGRLSSVGEETNLSASISTSPSSTKVERNNIDSPLQKIENSGFRMSQQNTAAEVFSHVKHRIKSDLPLEEFELVQRDELKSLDNDEFIDPITRDVERRMSMKEKINEVKGNIESGQTSGTFQATGNLQKAASFVKVYGTYATELFRGAFCKAKSIVSSNSTVTKLTKDDEDSCGDNEKDNISEGTPIVRSKNTKKGPFDFDGTRLVQELNNEHTGAVWCMKFSLCGRLLATAGQDNIIRVWVLRNHLAYFNKMRDRYNSQLKSSNVSLNETSLQKAMQEIEKDYHSSSNTLGNSVDSSDDDPNADSTFFVMAPKPLCSYRGHTADVLDISWSRNYFILSSGMDRTVKLWHLSRAECLCCFQHIDFVTCIAFMPKDDRYFLSGSLDGKLRLWHIPDKKVALWNEVEQVKFITAIAFVKNGKFAAVGTYDGRCFFYTTDQLKYHTVIDVRSSRGKNSRGHKVTGLAVYGDKLLVTSNDSRIRMYDLRDMALTCKFKGVQNERSQIRASFSPDGKHIVCGSEDHYIYVWTTSDLLSPLTVRKDRNDFWQRIQCHSAGVTAAIFAPRPQLFLSLLENRRAGENKRFDTLPHIKETDSRQLYGDVIISADLTGSIKIFANRTRIRAGGSNFFTTDVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC79</accession>
    <name>A0A0N4UC79_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syndecan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS483</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC79"/>
    <dbReference type="WBParaSite" id="DME_0000486201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000486201-mRNA-1"/>
        <property type="gene ID" value="DME_0000486201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044468at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001050">
        <property type="entry name" value="Syndecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030479">
        <property type="entry name" value="Syndecan_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915:SF1">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00964">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Neurexin/syndecan/glycophorin C" evidence="11">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000486201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8141" checksum="8185EA4284D9EE9F" modified="2015-12-09" version="1">MGRKECYCSHAFNEAIIGGFVVGVLAVILLVMFIVYRMRKKDEGSYALDEPKQPPHYSYAYQKAPTKEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCG4</accession>
    <name>A0A0N4UCG4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8758</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCG4"/>
    <dbReference type="WBParaSite" id="DME_0000495901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495901-mRNA-1"/>
        <property type="gene ID" value="DME_0000495901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27244" checksum="0D9AD9D981E57BCB" modified="2015-12-09" version="1">MDMKEEYNFASSSSKWRKYDSRKCAINCDEKHFIDSNRDSLEKISDERKLNPPLRLKKRTNINLRMIDGIPERFFYGDEPAEQIVESANREAVIKKQNDNFKKAFNEAKERRKEEQAKEEENSARRREIEFIDEQIKCWQRVLNLQKRLEEFKKKFEGDRERAASTVRATDNNEANATLEDVDLDSLMDWKRNRVEQNGTCNAGLVDHQTESRSERFGEEQISSALEIIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCU3</accession>
    <name>A0A0N4UCU3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8906</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCU3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCU3"/>
    <dbReference type="WBParaSite" id="DME_0000510701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000510701-mRNA-1"/>
        <property type="gene ID" value="DME_0000510701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000510701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55751" checksum="600FB881B1EC9E07" modified="2015-12-09" version="1">MLSNIFDNIDEYSLAFVKILGEGTFGSVKLFLDRKHSYLPVAVKCIANGQGGHNWRIRNEVVAIQKSLREENEIVKCYGFHHSDLETKIFLEFLDGGELFDRIEPDIGMAETDAHFYFRQLMEGMKAIHRHGFAHRDIKPENLLLNWKNCLKIADFGLATLYIRDGKERYLNTRCGSEHYSSPQLIAGYYSSFNQKLEKGVIFYYLRGEPNDIWACGIVLFILLTGTFPWTTVLSSDYELWTSDATCLEKSPWSNLTKDVRDLIVWMLIHNESHRATINEVQDCSWYKKGPITRTNITDAVNECSSSKRCSSLSGMVSQPSGSTDLLAIDRRRGTLHSLKKYSFSQPAYAFSEALFSRMSQLDSHQSQHINPATLFVRRSTRIFVNATTSNAIDKVLEACAVQNYVCISRCDSELSVSISRESSFIVAFVDVPEFSKPLLLLDFRRSRGDGLEFKRAFKKIESHLSSIMCEQNAEWLSTADRLAACSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD86</accession>
    <name>A0A0N4UD86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9074</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD86"/>
    <dbReference type="WBParaSite" id="DME_0000527501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000527501-mRNA-1"/>
        <property type="gene ID" value="DME_0000527501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041080296" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000527501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7559" checksum="EA1D7EAB595B0B3C" modified="2015-12-09" version="1">MSERAKSALIVWTFVLMIGWPTTAKQVLPMLCTDDLDRDRFYAKLANISPKNDIVVIAAGMCMRMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDA0</accession>
    <name>A0A0N4UDA0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Calcium-binding mitochondrial carrier protein Aralar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9091</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDA0"/>
    <dbReference type="STRING" id="318479.A0A0N4UDA0"/>
    <dbReference type="WBParaSite" id="DME_0000529201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000529201-mRNA-1"/>
        <property type="gene ID" value="DME_0000529201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="192"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000529201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36873" checksum="E5F6386E9A9237EC" modified="2015-12-09" version="1">MLESVYRFTIGSLAGACGATAVYPIDLVKTRMQNQRSSEFVGELAYKNSLDCFKKVVKYEGVLGLYRGLLPQIVGVAPEKAIKLTVNDFVRDKFTINGQVPLWAEVLAGGCGGASQVIFTNPLEIVKIRLQVAGEVHGATRIGVVSVLKELGFFGLYKGAKACFLRDIPFSAIYFPVYAHAKSATADENGHNGPSSLFSSAFFAGIPAAALVTPADVIKTRLQVAARAGQTIYDGLFDCFKKIMQEEGPTAFWKGTAARVCRSSPQFAFTLLTYELLQRIFYIDFGGIRPAGSEVPVNFPSYDVSMNPDHIGGYKHAAATFSGVEHKFGLFMPRFESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE05</accession>
    <name>A0A0N4UE05_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA topoisomerase</fullName>
            <ecNumber evidence="3 11">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS630</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 11"/>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE05"/>
    <dbReference type="STRING" id="318479.A0A0N4UE05"/>
    <dbReference type="WBParaSite" id="DME_0000558501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000558501-mRNA-1"/>
        <property type="gene ID" value="DME_0000558501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.460.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="15">
        <location>
            <begin position="168"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="686"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN50657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000558501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="729" mass="83942" checksum="0F7D7320FED26503" modified="2015-12-09" version="1">MKAMRALFVAEKNDAAKNIASILSHGKLSRRDSRSKWNKIYQFQADVLNTPNCFVIMTSVSGHLLQYRFPDSHRSWQETPIHSLFDAPLYKDVIPGMEDIKRTLIEEVRDSDVLVIWTDCDREGEDIGAEIVNICNVVKPKLDVFRAKFSEITQIAIWHAVKNLTKLDQHVIDAVECRSELDLRIGAAFTRLQTLHLRNVFANIFHDHKDVISYGSCQFPTLGFVVERYKTIQEFISEKFWRLVVKHVRNGVDVEFNWERQRVFDHDVVQALLDDCTDAGRASVVSVICKPKSKWRPVALDTIELEKIAVRKLKLNAKNAMSIAEKLYSQGFISYPRTETNKYPANFDLRPLVQSQVANSDWGDFAQAILAKGPNPKNGTKSDDAHPPIHPLKFASTDNLVGLDWALYELIVRHFLACVSWDATGNETKVQIRIGDENFVATGLIVDDLGYLKIYKYENWGDKLLPQYQQNEILNDYQISINEGQTQPPSLLTEADLIALMYKYGIGTDATHAEHIETIKSRQYVIIDKNGRFLPGYLGLSLVDGYDRMGYAMSKPHMRADLESNLKLICEGKKSKDEVLREQLAKYKRIFEQSEIKVKLLSDTFREYLNKQQENQNNELNDEQKRSTPNTERRKKKGAGDAMSTTGRKNRGTGRQIRNHRERSSEVATTNLNDVELLESNFHFFFFCFLPLCFLCSLFQGPNHGRYFWTCRKNRNDPAKCNFFEWEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE12</accession>
    <name>A0A0N4UE12_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS637</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE12"/>
    <dbReference type="STRING" id="318479.A0A0N4UE12"/>
    <dbReference type="WBParaSite" id="DME_0000559201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000559201-mRNA-1"/>
        <property type="gene ID" value="DME_0000559201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000559201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29356" checksum="6E28843119D92EAD" modified="2015-12-09" version="1">MVKAKGKRVPRLRRNYQLAPGVMRFSSSRMYSKRGLFIRKRYPVVVKTIEKKKKFVVKPIGGEKNGGERKVPIKKKPRFLPEREYVRKTRHNRTKKVPLRSSIKPGTILIILVGRHKGKRVIFLKQLPKSGLLLVTGPLKINSMPLRRIAQAFVIATKTSLDITGLQIPEHINDDYFRRINRKKEAKKGDTNIFAQGTEEYKVSEIRKADQKQVDKQILEIIRKHPEHKFMFGYLGSKFSLAKNQYPHQMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE18</accession>
    <name>A0A0N4UE18_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS643</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE18"/>
    <dbReference type="WBParaSite" id="DME_0000559801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000559801-mRNA-1"/>
        <property type="gene ID" value="DME_0000559801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000559801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="27025" checksum="DC935A5324CFA8EB" modified="2015-12-09" version="1">MGTYKLFEADPRPSGRNRPRLSRGLVLANIDLDRLNPPGDFLVRRLHEDTIRKQKTNAVEMRMLVDARRLAKILNLVKLQRSIVISSRFVDERGISLPRIRREDMSVTRSDPLERLFDLPDLLDRPGSLSICALSLESSGRNRPRLSRGLVRANSDLDRLNLRVDFLRRCWRRDNVDSEGDLDLDLELLPFKEYRRRAIIIKEIKELTQRLLIYKISTKILEIFRPFYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE80</accession>
    <name>A0A0N4UE80_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin carboxyl-terminal hydrolase 36</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Deubiquitinating enzyme 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein scrawny</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin thioesterase 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-specific-processing protease 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS714</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE80"/>
    <dbReference type="STRING" id="318479.A0A0N4UE80"/>
    <dbReference type="WBParaSite" id="DME_0000566901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000566901-mRNA-1"/>
        <property type="gene ID" value="DME_0000566901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="351"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000566901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75036" checksum="C626BDD089DD53B1" modified="2015-12-09" version="1">MECDTEIYASSSKSDIKEKTTGIESLLSSDNQIKFVASKQNFESEIIEKQPKNSQKMIHEKIEKDMAENKQKIEHRNRINSNASITPHFEKSDGLRLIRSAYSDLSPTPSSSGSPASSKKRLKVDEFSNVLLNESSGSVAKRSKSFPDNSINRGCHVSAESNYAISRYNMKFKRTTESEVKATNISVRVNSEQRSIMSSKNIASRIMTNVQPSTSTSSRFEPYNIKYIDYDRSGPGSIIIKKKFDNGIKTNGCHLDLSSRELSGNAPRNGSAFHNKMKNNGISNGLKKNCPLSNGSVVKGSARHGIYKNYVRNTFPCKRRFKIVDEKEFERQAKFPEIDLDLPRNGRYCGAGLRNRKNHCFLNVVLQIITHTPTLARYLTEQHLEDRSNGFSRELMCCFTCELGRHIMLSMENESTIVPSWIYPFVKRVFPGRADDDQEDAHEFLTLLLDALQRHHNFGKDFEMVINPSAIGGASVADQVFGGVLLNRFQCSSCAYVSENYERFRELNVAIGFGQTLTLEDLIGKHFGSEILTFHCAGCKKKVEARRETFIVNVPNVLIVQLKRFDCEGQKISQSVDFGLKLRLDRFMFDQGSIAEYSLNGLIQHFGLNITSGHYVAVVRGLDSISWHFFDDENHHSVGEPSFRKYDPYVLFYTQDFFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEI4</accession>
    <name>A0A0N4UEI4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Active regulator of SIRT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEI4"/>
    <dbReference type="WBParaSite" id="DME_0000579101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000579101-mRNA-1"/>
        <property type="gene ID" value="DME_0000579101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023262">
        <property type="entry name" value="AROS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15684">
        <property type="entry name" value="AROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000579101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21695" checksum="F198B8E4CAE27098" modified="2016-06-08" version="2">MSRSLLINSLDLVEKFDGVKWVRRGESGKGLPSRLRVSLGRAKHSLVSANKKLDFDEETSELIELSKNKRSSKFDHLSSKIPKNSSIIEEYRNRKKIDKFKRNLKYMQYSMNNHLDSKLTTQILDYIKESDKTRREFFQNIRQGQCGSKELNLRRLKKKNTSFFTDEDFNQVGQSQSQMNMVGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF28</accession>
    <name>A0A0N4UF28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bm3567</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS957</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF28"/>
    <dbReference type="STRING" id="318479.A0A0N4UF28"/>
    <dbReference type="WBParaSite" id="DME_0000601801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000601801-mRNA-1"/>
        <property type="gene ID" value="DME_0000601801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12931">
        <property type="entry name" value="eNOPS_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12332">
        <property type="entry name" value="RRM1_p54nrb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12333">
        <property type="entry name" value="RRM2_p54nrb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000043">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012975">
        <property type="entry name" value="NOPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
        <property type="entry name" value="NOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="250"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000601801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="75690" checksum="BF8E63446B5A974C" modified="2015-12-09" version="1">MGNVWKIMKIITDMHLFFALARKISHKLTRFSMSENNRDKSGSRGGGSSSNRQNSSNNGSGGATVNVVASGGENSLSRAKSDRRNNAVGRYVSYYFNYLCSYVDNFSPHHHHNHQRSRENINQSGGGRGHHGINMGVGGGGPGLMGAMGPRMIFSGQAFSETELMTDLPKKKFTGRCRLFVGNLPMDLKEEELKELFAPHGDIAECYLSGKGFAFLRMDTRAHAESAKEAIDGKIIHNRPVRVRFAVHGAALKVKELSPTVSNEMLYHAFSAFGEVERAVHIVDEKGKPTGEGIVEFERKHSANEALHQIREKVFLLTASPKPLVVEMLEPRDEDDGLAERMIQRNAQLQKEREVGPRFPPTNSFEYVFGLKWKELYEMERQRRNQLEDELKEARRRLEADMELAFQDYQTQMLREDLARRQQELERLEAAKRERMAQVAARRGEMPSSMMNNNLPGQGGPPQVGLGGPNAPSSGPQREFFVGGGSSGGNLLLFYFFSLPLIFHKHEKASLSSVFDHFFQCHAFTFLIIFLISFLLGHFGGPNGPDISRGPPNQGDMMGRGPPDNMMRNGPPMDGPMGRNIPPPFQQGPNQGPRPGGPVGSGTPGGQSGPGMGVPDPTLVQGVQKLLQIFRTDNPGGGRSMPQGPQGFGPNFMGPGGPPFGPGGPAGPFHRGPPINDFAPPSEKRMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD2</accession>
    <name>A0A0N4UFD2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9432</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD2"/>
    <dbReference type="WBParaSite" id="DME_0000613601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000613601-mRNA-1"/>
        <property type="gene ID" value="DME_0000613601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06670">
        <property type="entry name" value="PDZ6_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000613601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26676" checksum="C05EDB2B5F56C1AA" modified="2015-12-09" version="1">MASWSPCSTRSISPCGTPLQLKGSWASDIVYLPHSLERTIKIAKGPLSLGLVLDADADKGINGCKVKNICNKKAVGRDGRVQVGDYIVKINAESLRNVTNSQARAILKRTNLIGTNCNIVYITSTDAKIWRERYHQDSEMQMPVINRLSPKIFPKYYRSPFVARREHSSVEHTESFDSDIVSSDAMDSRNEVPQPIFQVRPQLRHAGSIVDGSEIEKFSYDIVLVSLFLIFLHFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFF5</accession>
    <name>A0A0N4UFF5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein RALF-like 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9461</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFF5"/>
    <dbReference type="WBParaSite" id="DME_0000616501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616501-mRNA-1"/>
        <property type="gene ID" value="DME_0000616501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15055" checksum="E786BFDB1E8F51A3" modified="2015-12-09" version="1">MGDSMRSPSKEFKWVAIGALMLMMCASSMYTKEIGNMNMDEYDGDNKYMIMATIGDNPMYSDQIPQAIVYDEKSLKSANKRSSSTYRLCGSRLIDAIKSVCGNCIKPIGFRPVEVKRGINNFLFFLLAFSICLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFT9</accession>
    <name>A0A0N4UFT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1219</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFT9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFT9"/>
    <dbReference type="WBParaSite" id="DME_0000632201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000632201-mRNA-1"/>
        <property type="gene ID" value="DME_0000632201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF76">
        <property type="entry name" value="ADRENODOXIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000632201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14940" checksum="8D871A3CA28EDAA6" modified="2015-12-09" version="1">MHFMNAIVRLSGSSARRLLSTKSRQIKVRFVTNDGIHEALGKEGDSLLDVVINADVPLDGYGACEGTLACCTCHVILEQRHFDRITPAVEEEHDLLDLAPELSETSRLGCQVFLSEADAPEISVRVPSIIDDVRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGB7</accession>
    <name>A0A0N4UGB7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PRORP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9639</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGB7"/>
    <dbReference type="STRING" id="318479.A0A0N4UGB7"/>
    <dbReference type="WBParaSite" id="DME_0000652801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000652801-mRNA-1"/>
        <property type="gene ID" value="DME_0000652801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000652801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="559" mass="64166" checksum="781437F3589A5369" modified="2016-06-08" version="2">MSKTFSALKSDRKICGESRDKYFDCIDVRGEENCVKEKKVFEESCPTSWTLLAPSNLFCGIINSHSTPSIMNKDLVPSIFAKLQISHEDSLRFVDVEYYRQTTKFADDKRALLTFCEKKFWRSARTYMQVLIKDNVSYPLSLLAMCLTLTHIYLSRVNVPEDENIFSFLVDKIGNVGPLKLAASLFLQCCHPLSSFPRRFINDGNIKFFEDLLSTKPDLILVDSPLLLDIMANESSKMPILAEIILDHLVLQKRPLIAEERTAFITILRESKMWNLKKTKMTTDKFCSVCGNCLPAAKISNEEREILLDDVKKYIKANITSHILCSPAEYNAFIKHVNTILKLHFAPCAILEAGKNDYYDYSLNFSMFSLTLENGRSLVVDYLNSIYSANNPEKLLLRLNDDFTTIFLISRDGPASRSIKWVRKLGISIFLCDFRSQDDLFILLASLMLDGYFLTNDKFLDHRLKISPSCRILFDKWIRYRGVRIIKSKNTYTVSLLIMPGLHTYCMYHRARDIMRGERGRHVKKPDPFTMESFGDIFTGGFPAAARVFDIMTDLLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGF5</accession>
    <name>A0A0N4UGF5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1303</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGF5"/>
    <dbReference type="WBParaSite" id="DME_0000657401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000657401-mRNA-1"/>
        <property type="gene ID" value="DME_0000657401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000657401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14119" checksum="EE0BBE242D075748" modified="2015-12-09" version="1">MELNYNSTKKKRAPDPPLFSENKNTTLDIGAIDNANKKTIVQTTTIELKANDNQEKSVDYNHRMINHNNFTDKIGISKEENAQKISSYNKGSGSTSNYQINFSEIFIGKQQSPRKFSSMNGYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH37</accession>
    <name>A0A0N4UH37_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1451</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH37"/>
    <dbReference type="WBParaSite" id="DME_0000683701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000683701-mRNA-1"/>
        <property type="gene ID" value="DME_0000683701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877161at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000683701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8849" checksum="7340015DF5F8A9E2" modified="2015-12-09" version="1">MDEKFKKRKEVSDENIQNFYVDNIIVAAKDTEKALRKYKAIKKLFGGIKMIIRSFVSNDKQLAKKTEAIKPNQLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHC2</accession>
    <name>A0A0N4UHC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9775</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHC2"/>
    <dbReference type="STRING" id="318479.A0A0N4UHC2"/>
    <dbReference type="WBParaSite" id="DME_0000694301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000694301-mRNA-1"/>
        <property type="gene ID" value="DME_0000694301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905">
        <property type="entry name" value="NINEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905:SF13">
        <property type="entry name" value="NON-CENTROSOMAL MICROTUBULE ARRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="874"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000694301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="933" mass="108521" checksum="7629D498F87F465D" modified="2015-12-09" version="1">MTTVNIDNDNVHIKQLNALFLECANNGEAYLDQGGLHTLCEKLNLLSSIDLIIERVLCGYNVVDFPTFKERFVRLLPEIVNFDSIDIKLQKEIEKTLSQLGFNLHSFLNQYDIRLICENTPQLNRLNTVDINDLFGRADSKHAGRITINQFLNQYQIQKQLNDEVNFIAETFAPSVNLFEAIDTNNTGIVDVQQLVEHWATCGINIEQSLAALKETGLPLHGSINTISLSGKLERELSDVAISSSASNLIRVALLSLHAYIDHLRYLSKEGESRCDHLHKQLQLANQRRNLLIEELEQNQASVEESYEQRLRQCEERYRARISQLEERFSTEKRDLIKEVERMEEELSRVRYSESTCKTRLQLVERQCARFGEEAQEMAESMQKMEHANRQLRAELGKALHPRQIDENAQILMWRRRVEFLLAHNKKLRDKIDEMASSKKKYNFYRKINPLYFHWTNSFRLKVLAIRKRRIERNNSLSEMESEPESIFIRVRRRRLLKVRERMRIHQRIEQSVNANKIAVEGTSSEETVNSLVRNSTSERNLVSLLEKKHEELKRLKDEHRREISALKLSANKALSDALNDQQRQITQSFEKERWQFDVRLASERNALERKFAEEKMKLINRLQEEFDLELNRLKALISPCVSDDSYLYKNQNEVYFTIILIALFAELPNELSSKKMDSHNAKFTNCDGRYLNRKPQDCSVSDNAVPSTSAFVLLIEKYRAIAPTNKHHFIEKRSSNSIEKASSHSSLPIFFDKLKQSPLPQKCNRCELIDKRLKELLSVISNENIVIESGFEDIDSSIEGINEEVSLIKTENKTLKSRLELLRVKIIELRLCLSGSGTMYRKYDCMLGGSENSEMRQFNTKNFAHNFCGSMLVGNFRRQIIRLEAEKALLNARLIELKELVKHLVNKYKEQLDETSRLGDIFRRIYSKVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHW4</accession>
    <name>A0A0N4UHW4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000027">
        <property type="protein sequence ID" value="VDN51662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHW4"/>
    <dbReference type="STRING" id="318479.A0A0N4UHW4"/>
    <dbReference type="WBParaSite" id="DME_0000716401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000716401-mRNA-1"/>
        <property type="gene ID" value="DME_0000716401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863314at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000716401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17868" checksum="097E7158E774C552" modified="2015-12-09" version="1">MDDIWRNIWSKLSARDQLLCKQVSKQWMKRIRELCLARQTIDSEVLYRCGNSVTTFRFGIDRKFVCGFNPRTTLDPGVILKLFRHSPNLKKIELYGAFLPPSLFTLFDLMPQSLEVLRINSCVIDATESGTIRNALITVFRRCSGLKEFTIIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI99</accession>
    <name>A0A0N4UI99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9959</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI99"/>
    <dbReference type="STRING" id="318479.A0A0N4UI99"/>
    <dbReference type="WBParaSite" id="DME_0000732301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000732301-mRNA-1"/>
        <property type="gene ID" value="DME_0000732301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF11">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041679" evidence="1">
        <location>
            <begin position="19"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="630"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000732301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="930" mass="101569" checksum="17221CFD40B6691B" modified="2015-12-09" version="1">MAKWLFCFLIYTSQHVQAQHGTVGRPCEASTDCGTGNYCTGNKKCACLTTYVEIDSYCWRKISPGESGCMQNRQCEAVWPGAYCKSGVCRCANNNPPFRTRDGLVCLSYGLCPLNGNNPKFRIKNEVQQCYGGSDASCEAIGALAYDCICDKPDCTADNPISFCCPSRAFACIQPPNEGYTSPDGGTTLNHWYHDPITGECRELKYLGNGGNANNFQTKDHCESYCKQTCNRGLPLYRDRIIGAKQEPVYCQGDDSGCNNPNYVCTSMGTLQQCCPSHTHICSRSGGIPIEVYNSVGGVPTDYFDAGVEDGTGNIYPRFYYDSREGRCIQFSYYGQGGNFNNFLSQDHCEKFCSRILCSAGEPLKDSSGERNMDCSPSGSGSNVCPSTHSCESTSGSAIFGGVCCPKSQYVCKLPREQGNCGTYSNRWWFNAKTGNCEEFVYSGCQGNANNFETYKECQDYCRDARSEPQCIQGTALTDSNGNFIICGGSTSITTTCPANHYCYYDGTTYGCCPTQAHTCSLSPKRGATCGPAVTRWYYHSSSRTCQTFSFSGCDGNSNNFATQQDCKDYCRVESCPDGGEVWKEYNGAVRTCTTNHQCPSTHYCTPVTAWTGSVYQTKSLCCPSKNYVCSQPRDTGVRCSSTRITRYNFNPELKTCQSFEYNGCGGNRNNFANQKACQSYCLSESCPPGTVVAKESDSSRLMKCSNPGGAGRLSGGCPEGYSCYSSVLLGQNVCCGASTDLQSLCPSGSTPFISALTSQPMQCTPNVDGSCPGNFFCWFSTTSNAVNAFYCCRSPTTVDTGYCPPHLISVPGDDGSQYRFCSPSAPVSDLRHSCGANRHCQYSTSLDRYICCGLESELRLSNICPPKPPNLMPVIMKNNYRTCSPRSRPGTPLYCPDNSVCLYTGDQYGFVCCKVSFFFKYGKNGICHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIE8</accession>
    <name>A0A0N4UIE8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1738</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIE8"/>
    <dbReference type="WBParaSite" id="DME_0000737601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000737601-mRNA-1"/>
        <property type="gene ID" value="DME_0000737601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10550953at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000737601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12007" checksum="5419D4B73832AE9C" modified="2015-12-09" version="1">MYAKKNLVSLTKSNDFNPITTRQPINEICGATVIQVNDTSYRGSVGSSRSSSCERIQSDLSAVTRVDLSSRLTQFEPHHGTPRSVKYRNKVDLAYNLDKQIGLFVNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJY2</accession>
    <name>A0A0N4UJY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2121</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJY2"/>
    <dbReference type="STRING" id="318479.A0A0N4UJY2"/>
    <dbReference type="WBParaSite" id="DME_0000799601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000799601-mRNA-1"/>
        <property type="gene ID" value="DME_0000799601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877161at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000799601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15291" checksum="CE5CC14B018D499A" modified="2015-12-09" version="1">MVGIKNYSLTPIQNGLTSPNSGDLIQFVYTVLLCPIKAILVPRLEFLAVLIGTRLLTFVVYSQLDCNVAQYLWTDNKAVLDWINNSQKGQERFVQNPLLEIRKVQYVQLNYILSMENPADIATRGTKNRYILIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJY7</accession>
    <name>A0A0N4UJY7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2126</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJY7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJY7"/>
    <dbReference type="WBParaSite" id="DME_0000800101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000800101-mRNA-1"/>
        <property type="gene ID" value="DME_0000800101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000387">
        <property type="entry name" value="H(+) MyoInositol coTransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000800101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="592" mass="65895" checksum="5253C17E0EEB3391" modified="2015-12-09" version="1">MPKEKPKIGCYVINLAVMAVIGGFLFGYDTGIVSSTMLYVSQNTGMKPMNSLWKELIISITPGFASIGALFAGQVADRYGRKKVIILSSMVFVAGALICGIAPEKVTLLIGRLFLGIGIGFASMIVPIYLGEVAPSHVRGLFLTSFQLMITFGLMASNIIAGALSYIDPVKVGWRLMFGFAAIPAVIQFIGFLFLPESPRWLYSHEMKYDAEKVLNNIYGNNIEWVEYEIQEITEAHEEEERAKKIIGDSLTIARVLRTAHVRKALIIGCLLQALQQFAGINTIMYYTGTIIRSSGVRDIQITIWISVGISAVNFFATFIPLYLIEKIGRRVLLLLSVAGVILALIAMGVAFLLINKESALVIPYNITSFSDHLSDRAVRCSSYRNCDLCVTDEHCGFCEIKNISRTGICAPFNESDSALSAFGPCSRDPIDASYDWADNYCHTKYTVLPIIVMVVYLASFSVGFGPLPWALNAEFYPNWARGTCCSLSTFTNWVFNLVISLTFLTLSEHATKYGAFFIYAGITCFSFVFFFFFVPETKGYNIEEIELLFMSKKKRKAVITAQDTNLTKEFSLHNDNEKQTAIDSYQHENNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKQ7</accession>
    <name>A0A0N4UKQ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10352</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UKQ7"/>
    <dbReference type="WBParaSite" id="DME_0000833501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000833501-mRNA-1"/>
        <property type="gene ID" value="DME_0000833501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977517at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20237">
        <property type="entry name" value="PFM_LIN24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369:SF6">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000833501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32882" checksum="C12397B0F72CF701" modified="2015-12-09" version="1">MKAEQNDLVRDIRINADRINTSCSSGLSSRDLVDLEAIVLNWAKQIFEITKNKNEARINKKHLQYNINWSHLFNECLDPTYSIDGIDTKSTRQTKEEQTLFKSTFTNTTEREQEYSFKTERSTRSSVTVAIEKGICRGVELALKLKTPCEILEANAGFQNEISVYHIGENTTEEELTWGVDSTVRVPALCETVAELVILEDHHIRKFSIECQLSGRIIVTVTNLKDNNSLVTIIEGKIADIIRALPNCASLGFVVQNDTVIYITKGICKFKYGVEQKVRIKEYAVRRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKU0</accession>
    <name>A0A0N4UKU0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2378</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKU0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKU0"/>
    <dbReference type="WBParaSite" id="DME_0000837201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000837201-mRNA-1"/>
        <property type="gene ID" value="DME_0000837201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000019">
        <property type="entry name" value="60 kDa heat shock mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000837201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="61425" checksum="918FC70C1A887C33" modified="2015-12-09" version="1">MADRIAVEMLRLCSSRCLRSSLRFYAKDLKFGSDGRAAMLQGVDTLADAVAVTMGPKGRNVVIEQSWGSPKITKDGVTVAKAIDFKDKYKNLGAKLVQDVANKTNEEAGDGTTCATVLARSIAKEGFENISKGANPVEVRRGVMKAVDIIVKELKAMSKPVTTPEEIAQVATISANGDENIGNLISEAMKKVGNKGVITVKDGKTLIDELETIEGMKFDRGYISPYFINTTKGAKVEFEKSYLLLSEKKISQVQDIVPALELANKYRKPLVIIAEDVDGEALTTLVLNRLKVGLQVAAVKAPGFGDNRKNTLKDMAIATGATVFGDEANLVKLEDIQVQDFGEAEEISITKDDTLILRGKGSAEEIEKRIVQIEDEIEQSTSDYEKEKLNERLAKLSKGVAVLKVGGASEVEVNEKKDRVTDALNATRAAVEEGIVPGGGVALLRALKALTNVTLDNADQQKGVQIVKKAVREPITTIVRNAGIEASSIVEKVIANDDKAFGYDALSDKFVNMIDAGIVDPTKVIRTALQDAAGVASLLATTECVVTELPKEDPPMPGGGMGGMGGMGGMGGMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULL0</accession>
    <name>A0A0N4ULL0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease</fullName>
            <ecNumber evidence="6">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2603</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC93 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULL0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULL0"/>
    <dbReference type="WBParaSite" id="DME_0000868801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000868801-mRNA-1"/>
        <property type="gene ID" value="DME_0000868801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16092at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039116">
        <property type="entry name" value="CCDC93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019159">
        <property type="entry name" value="CCDC93_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048747">
        <property type="entry name" value="CCDC93_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441">
        <property type="entry name" value="FIDIPIDINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09762">
        <property type="entry name" value="CCDC93_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21673">
        <property type="entry name" value="CCDC93_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="9">
        <location>
            <begin position="575"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000868801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="821" mass="94612" checksum="FA66D2ED5F696E7C" modified="2015-12-09" version="1">MSPSMVRAHSPSPTIRVVAYFVNCVMVGVKSEFDIREDEEQRAKLQDIIDLLVAAGYFRARIKTIPPFDMVVGGMVWCISHCNMSLDIDLFYSDISTIGQKIWLTERIVEVLPQLACPHAIEPHQIQGLDFIHIFPVIQWLVKQAIEAKNQFGDDSRNYAVYQFNKRFSLSQDMENWMKNSKIGCNFRILKSFCLPKRVSRRIYEYRCLNLIEDLQCTLMEYEWPGTSSNRDFTKNSGAEKFIENEERLSGNLTANVEQLKSEHLSAKALAELISIEDLKKTLDSKFFQSTEERIHSKINFANSLANIESELEKLKLEENQLEELLNVADCNYRKYEKELREKEENLSKYRSEVENADIKLIEKLRQLISEHDDLKKRETDFKINCKMEMKKLEEKIENFCAGSVAENGADIHNLKSKWQGAQKRLTILRQELANINWQIALEQRYIDSVPLQLEISQYQRRIIELYNQIASKHQEMTRYFALHNTLVDIQAYIQREIALLNSIEEVQHLTSRDSYKESFFENLQEILRGISIKRNELQKERDNLSDDYQYMLEKELCMKAEQSYNFEKFGDGRACILGIDEAGRGPVLGPMVYACAVSPLGCNEKLKDLGVADSKTLTRTKRNEIFSSIQSETNGRFMAYAVRILSARMISAAMLRRCKYSLNELSHNSAIDLIKSAIKAGINVAEVLGPKETYQAKLEEKFPDVKFIVIEKADTLYPIVSGASIVAKVTRDENLRKWSFIEGEVKVAKNGFGTGYPGGMLAGHILFFEILQRRIQQLALIRSVCFRQSLLCVMLFLMIAFLPMSAIFNSSGHYYADMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULR9</accession>
    <name>A0A0N4ULR9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2647</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULR9"/>
    <dbReference type="WBParaSite" id="DME_0000875601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000875601-mRNA-1"/>
        <property type="gene ID" value="DME_0000875601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000875601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10081" checksum="A887BFEFC7BE5723" modified="2015-12-09" version="1">MALGPDVPTFIPPIYAFSTAEEICVKRCLLLRAPFAAIIAKHIKNRGKISGTTQLRITVRTSSKTILHCIRHQSQRKPEAYKTHNIIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMY8</accession>
    <name>A0A0N4UMY8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chondroitin proteoglycan 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2983</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMY8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMY8"/>
    <dbReference type="WBParaSite" id="DME_0000924601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000924601-mRNA-1"/>
        <property type="gene ID" value="DME_0000924601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5816387at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039260">
        <property type="entry name" value="Cpg-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37973">
        <property type="entry name" value="CHONDROITIN PROTEOGLYCAN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37973:SF1">
        <property type="entry name" value="DICKKOPF_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000924601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25081" checksum="BD8D967BF333E483" modified="2015-12-09" version="1">MDFAGPHGLNISLAMKNISSLSNALTKKSLEPLEIEKQRDEVADDEETEENEEAEESKVESEADYKTEAANDDMTSTGTEFTTMSSEVTTVEIHDKDSNTTELVNSINDTKEVEIARFSDEKRNNSELEHCVPKKVCSLDKDCGSGKCFAVGKCDCSACMSLARCQNDSDCGGLYESCDTKTNICNCEKGLRIHGLSLFDALFKFCNILVCNGKGDACLGLPCRTGTCIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UND8</accession>
    <name>A0A0N4UND8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3127</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000106">
        <property type="protein sequence ID" value="VDN53154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UND8"/>
    <dbReference type="WBParaSite" id="DME_0000941601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000941601-mRNA-1"/>
        <property type="gene ID" value="DME_0000941601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000941601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9122" checksum="416A070B5F094E88" modified="2015-12-09" version="1">MRPFCKKIASDCFEDGEYETKFQMLKKFWTRKVGKTVENIRATQDMAHDERKRLTFPTLQIPCSSITFIGSNNKIMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNI1</accession>
    <name>A0A0N4UNI1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3163</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000110">
        <property type="protein sequence ID" value="VDN53190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNI1"/>
    <dbReference type="STRING" id="318479.A0A0N4UNI1"/>
    <dbReference type="WBParaSite" id="DME_0000946301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000946301-mRNA-1"/>
        <property type="gene ID" value="DME_0000946301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20016">
        <property type="entry name" value="FH_FOXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000946301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25293" checksum="BEB4C8B7808931F2" modified="2015-12-09" version="1">MIFLTHLETLIKLSLLSVKQWTIFDSSLQKPPYSYIWLTYMAIQNSDEKMLPLTEIYKFIMDKFPFYRKNTQRWQNSLRHNLSFNDCFVKIPRRADRPGKGSYWAVHPKALGMFENGSCLRRRKRFKIHQGCSTNEEFGRDQPKLSYPTANFPWIFPSQSLMTHTLFDPQQFFFHKNNFLLLPQYASNHIISRTPTPRPNCNSFTIASILSIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNX3</accession>
    <name>A0A0N4UNX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine-rich glycoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3285</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000119">
        <property type="protein sequence ID" value="VDN53312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNX3"/>
    <dbReference type="WBParaSite" id="DME_0000963501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000963501-mRNA-1"/>
        <property type="gene ID" value="DME_0000963501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10621794at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041161210" evidence="2">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000963501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17863" checksum="7B174DD68D2A01EC" modified="2015-12-09" version="1">MLFSLLLLALISLRLSNASGDWWWGRFPQWSSEHGYGHLGENDHGHGHNHKYDDHYDHDYEHGHNDKHIGDYEKSSAHGSQSDWGNYDYGGRGDYLKEHAYKKGYGHSDGEEHGNKWGHSSGYHHDDQDDGHHHHGQHKGQHHAHSYEHHHHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP58</accession>
    <name>A0A0N4UP58_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AMP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3342</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000125">
        <property type="protein sequence ID" value="VDN53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP58"/>
    <dbReference type="STRING" id="318479.A0A0N4UP58"/>
    <dbReference type="WBParaSite" id="DME_0000972601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000972601-mRNA-1"/>
        <property type="gene ID" value="DME_0000972601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="323"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="6">
        <location>
            <begin position="556"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000972601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="619" mass="70785" checksum="9B1DA18742FF0CE3" modified="2016-06-08" version="2">MDNRLHELRHYLANYTPRIDAYYLPRTDAHQNKYIRERDNYVKFFSGFSGSEAEILVTKDEAILWTDGRYFIQAELELYDDWDLMKKGLCEMSPIDWLISIMPDRSHIAFDSILMTCEDALKFIDILTKAGFHVTALRKDFFAEIWLDRPLEPTHPISLLHISDHGLDSSSKISTVYSILGKKKCSSAIFTSLEEIAWLLNIRGADIPFTPVVFSIVILAHNGAHLFIDLRKLDEGTRRYLEKYVTIHEYDEAIEWIIDWNTRTSRLNLHKVILVVQVNFFLQVFLPSNINYLLASIIGPENSIIDQSPIQKLKAVKNETELEGMRHANSRDSRVVIEFLHGISTAIGKPNGDKITELSMIEYIDNLRSKAFSFLGLSFATIAAVDDHAALPHYHASAKTGKREVTKDSICLVDSGGHYIDGTTDVTRTFTFSDRVDDEFKHMFTLVLKGHIAAASLVFPKFTNGMRIDMIARQYLWAEGYDFIHGVGHGVGHALNVHEGPVQISYRNYNPCGAIEKGMVLTIEPGFYLEDEWGIRIENCYEVVSAENLRSGSNDYVAFRPLTLVPIQTSLIKKDLLTTSEITWINEYHQKCLHEHSYHFKAENKLDILQWLENACKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP67</accession>
    <name>A0A0N4UP67_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3353</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000126">
        <property type="protein sequence ID" value="VDN53380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP67"/>
    <dbReference type="STRING" id="318479.A0A0N4UP67"/>
    <dbReference type="WBParaSite" id="DME_0000973701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000973701-mRNA-1"/>
        <property type="gene ID" value="DME_0000973701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000010">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000030">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="70"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000973701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31623" checksum="7C717B8708105B9D" modified="2015-12-09" version="1">MYLYFSAAVNSAMILKLPVWKSFSCYCRRKSSFIRNVESIIPQLEEVLGYKNVNISDAVRDQHSHDEGHHPEKRPDVVIFPKNVIEVSTAVKICNEAKIPIIPFGTGTGLEGGINAIVGGVSMDLMDMSDIVSVNVADFDCVVQPGVTHKSLNARLRDTGLWFSVDPGADASICGMAATCASGTNAVRYGTMLHNVINLQVVLANGDILYTNGKDRRYRKTSAGFNLTELFVGSEGTLGIITEATVRLNARPLYCCVTVCSFSTVREAVDAVVAVLQCCIPIAKIGESGTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPC0</accession>
    <name>A0A0N4UPC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3392</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000129">
        <property type="protein sequence ID" value="VDN53419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPC0"/>
    <dbReference type="STRING" id="318479.A0A0N4UPC0"/>
    <dbReference type="WBParaSite" id="DME_0000979601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000979601-mRNA-1"/>
        <property type="gene ID" value="DME_0000979601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803434at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000979601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="54474" checksum="DAC53623EA07CF9F" modified="2015-12-09" version="1">MAIWPFRVEDIKKLSAFDHSCLRYILRVRQVEKYDRIYHRSNITCINSGPAIYGRWKKEWFLLLSTIASEHIPWKRLTLSLSEPKITREFRTRIRQTCNEACKGNENSKPLLQIFRKKSASTELALLENGLQELSLTSKFTSKIAETQQKALNTLTEWAKSSQNAAIDDVMQNTNELFRLFSEKQIRFAQDYNHFLQQLEKIVEDEREITKAEHQVNILEEKERKLRKEIQKRPSFFRRGGDIFLLRQELDKVIADKEKAKRIFGETRAEMEVIKMFRFRKGMQGIADSYCSLANKCHAVFTCHREITELVPAISEQDVQRMVYDGMHIARERVNNLRRSLNRITSTDNLRQSIRPAKRNEPSHRLHRNSFPSPPPPYSTLEQSLSSNRNNQSTENASETINDHVWGHKRYVPHASSQTSSKLHKGMHSYSFPLIQRLYPKLPKNPYLVMKKQHASGLIPKPPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQF7</accession>
    <name>A0A0N4UQF7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3744</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000177">
        <property type="protein sequence ID" value="VDN53771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQF7"/>
    <dbReference type="WBParaSite" id="DME_0001024301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001024301-mRNA-1"/>
        <property type="gene ID" value="DME_0001024301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001024301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22726" checksum="77B6D454347CA241" modified="2015-12-09" version="1">MIAACSSERILMDQMLQYSNFHSQLNDYENHWNIPFRKKRILLCSFALLNTASCISLIIASQNLLGIQLLAFTNLLAAFVVTLGIILCIRRLLIAGLIYMTVFVVFQLVLTCNIVEECLGRGETLFKRKDIWIIIALVSNIIELKLITTVVTDLPYYKRVTQPPLYSNCVNEPTILRVDSLPTYEEAMNMINLRCAAGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQG6</accession>
    <name>A0A0N4UQG6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3759</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000181">
        <property type="protein sequence ID" value="VDN53786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQG6"/>
    <dbReference type="STRING" id="318479.A0A0N4UQG6"/>
    <dbReference type="WBParaSite" id="DME_0001025301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001025301-mRNA-1"/>
        <property type="gene ID" value="DME_0001025301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF159">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="188"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001025301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37076" checksum="8714B43A2C7A2587" modified="2015-12-09" version="1">MCLANDMKINHFDVLLDKETNKAYIGGEILKGVIEIGVSEKVKVARLIIRLNGCIQTRWKNKISDIMYESNEQILNDFIDLTRLLVEHCDENYDLMNGLHRIRFQIPLPLDLISSIEKENYGWVRYTCSATIDVLDVEAKELCAERNFTVHSLLNLDAPYMRESTSNKEESEIYSCCFKKSIGMRSAEMVVADMGLLPGETAHITLTLENTSKRKLRRKHQNIPNNCCLISLCQQLDFLAQNRYELHMFDRKSLTIVVESIVTCETSGEGFQTKHIDFPVPADLQPTSIKDNGLITISYFFKLDIDDFDVIVPIIIGSFKTPGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR26</accession>
    <name>A0A0N4UR26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001273">
        <property type="protein sequence ID" value="VDN60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR26"/>
    <dbReference type="WBParaSite" id="DME_0001049401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001049401-mRNA-1"/>
        <property type="gene ID" value="DME_0001049401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001049401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12015" checksum="150FA1626B3DCB32" modified="2015-12-09" version="1">MKHGCKSVTYGTWLQRCHIWNMVAKVSHMEHGCKGVTYGTWLQRCHIWNMAAKVSYVGHGCKGATCGTWLQRCHMWDMVAKASHDGEFSKLTKYDFAYNLVTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR53</accession>
    <name>A0A0N4UR53_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10925</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001277">
        <property type="protein sequence ID" value="VDN60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR53"/>
    <dbReference type="WBParaSite" id="DME_0001052401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001052401-mRNA-1"/>
        <property type="gene ID" value="DME_0001052401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="234"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="322"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="422"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001052401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54760" checksum="1C2EE087E9C67745" modified="2015-12-09" version="1">MKYTDDVSSELICVQECACISEQYEKKDGQCIEKNDTATRIEAELSVENLFKGTEKVTPTSTQRFVTKEFSAQITAQKTPAEVPTPKVCSGRICRLDEIITDTLCSLTDQKCGPNMVFRTIVGPLRMKVGISSYKMCIQQCTCDSNEYTKIGGQCIKEKSVPMRKETELSVENLFKGTEKVTPTSTQRFVTKEFSAQITAQKTPAEVPTPKVCSGRICRLDEIITDTLCSLTDQKCGPNMVFRTIVGPLRMKVGISSYKMCIQQCTCDSNEYTKIGGQCIKEKSVPMRKETEFDGEILPKHCAGRVCALDEEIFNAPCSLTGKICGTNMIFNNIGKLLKKNGTVVCFQKCTCMSEEYVKANGQCILSAKGNENMSPALSQRSITERSQFPVQPTIQKISKTHSNYAGRSCERVRDLFCTLTGQTCGDNMVYKTIKRLIYIDDSPEICIQQCKCANKEYTEKDGRCIIRERSVKKNHAHQVTFYCAIAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR99</accession>
    <name>A0A0N4UR99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3506 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4001</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000243">
        <property type="protein sequence ID" value="VDN54028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR99"/>
    <dbReference type="WBParaSite" id="DME_0001057301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001057301-mRNA-1"/>
        <property type="gene ID" value="DME_0001057301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001057301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8157" checksum="4EBC943C6B39380B" modified="2015-12-09" version="1">MSSAEELAAEYERGDLEVGKGSAKRSKVGYFAEIRPKTVFSESFVGLEFLDNRLFRISAGSSQLQTCGSMIGSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URE8</accession>
    <name>A0A0N4URE8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTCK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4048</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000260">
        <property type="protein sequence ID" value="VDN54075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URE8"/>
    <dbReference type="WBParaSite" id="DME_0001062701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062701-mRNA-1"/>
        <property type="gene ID" value="DME_0001062701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31684" checksum="97D86CFC9199CF93" modified="2015-12-09" version="1">MYSLTDQKCGPNMVFKNLTGPLIMKAGMSSYKICIQQCTCDSNEYMKMGGQCIKKSSVPMRNETEFGGEIFPKHCAGRVCTLDEEIFYVPCSLTGEICGSNMIFNNIGKLLKKNGTEVCVQKCTCMSEEYVKANGQCILSTKGNGTASPALTQRSATEHPQLPVQRTIQKHPTNCVGRSCERIRDPLCTLTSRKCGDDMVYRAIERLTYIGDYREVCIQQCKCANEEYIEKDGRCIKPKKENQMEAARKATTRDRHWYAKYRKNMSSYLVHLSSDKKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URU4</accession>
    <name>A0A0N4URU4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4179</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000364">
        <property type="protein sequence ID" value="VDN54206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URU4"/>
    <dbReference type="STRING" id="318479.A0A0N4URU4"/>
    <dbReference type="WBParaSite" id="DME_0001077601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001077601-mRNA-1"/>
        <property type="gene ID" value="DME_0001077601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001077601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14275" checksum="33BD910A3DCF1CAA" modified="2015-12-09" version="1">MRQYSGLASIPWLLNSEFYPLWARSTGCSISTFFNWFFNLIVSLTFLTLSQAITKYGIFFLYSGITAITFVFVYIFVPETKGKSIEEIELLFISKNERVKRRKKNLINAFHLVEFRYENEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2L1</accession>
    <name>A0A158Q2L1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4721</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2L1"/>
    <dbReference type="WBParaSite" id="DME_0000036101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000036101-mRNA-1"/>
        <property type="gene ID" value="DME_0000036101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5783891at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000036101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39644" checksum="DE41E3CA8E3920E5" modified="2016-06-08" version="1">MNDSSEFCSYVPPDFLHERFWLVSVAGTTTAVLSIILNIILLIVLLKRRKYRYSYLLYSLLLAFFDILIAVSYVPLMSLSHLADFLESPFLLRSWFNYMLPMITISHIAMTSSSFLMLAASFERYCMVAKLDRIKWLTTHRANIATVAFIFGFFTKITLAFEFNINHNLECKESMLEYNLELSVLAQNPTYNLWWRLWFRNIVTVLFPFFLLSFLNIQIVTYLQQKKQYEQCYLNEFQRKMRIRAATRTLVLVVFTYLLSNVLNVIITIWEYIDMESLTTRFRTFYIFSVDTVSLMTVLAGALRLPIYMSCQPELRAEVLRSFSSLFTQKLRMKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2N8</accession>
    <name>A0A158Q2N8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2N8"/>
    <dbReference type="STRING" id="318479.A0A158Q2N8"/>
    <dbReference type="WBParaSite" id="DME_0000053501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000053501-mRNA-1"/>
        <property type="gene ID" value="DME_0000053501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000053501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22274" checksum="FBB5FB26D1D80606" modified="2016-06-08" version="1">MPPSYESLFGEFRQVENPKSLAQFLAKATAFVVSTVTAAVLLAFLNIIPLFMVVLGSMNIHRCPIEPYIPVWLIITGVFSLFKSATNFYYRAKRHREGRPPSVSDINPNPFDGLLSCFLIVWFIIGSVWIYSIYDEVHYFYPEDSDYCDQFTYMFSFVFVTGGYILLALTCCCLCCCCCCICCRPKREAPQQLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2W4</accession>
    <name>A0A158Q2W4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5310</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2W4"/>
    <dbReference type="STRING" id="318479.A0A158Q2W4"/>
    <dbReference type="WBParaSite" id="DME_0000095001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000095001-mRNA-1"/>
        <property type="gene ID" value="DME_0000095001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10519">
        <property type="entry name" value="SET_EZH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="10">
        <location>
            <begin position="413"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="525"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000095001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="658" mass="75490" checksum="4B6462E4F7F1D8D0" modified="2016-06-08" version="1">MNARSSRKRTSNIDAHNSRITKRRTVRNDLNVFNGDIDSESRSSDGFHIEKKSIPKELLDDVLAIYAEIRTGYRKLIKTEGLVKSKIRPLNLKPPHEQPTIFSIRSVTNAVLQTCPTKCLEHVMATPRMQYWTLTESNIMCEDERTLSHIPFLGDNEDDAGFCEELLKTFEEGIHGTREGCGEFINDFMLYHLLKRLMKKRSEDPDMIYRAVYERFPNKASVEHLPFLYADLRRKYSFEDTKGEELLTEDYMDARALHSFQLLLCNRCFTYDCLLHGVNSGESESHRQRSTTNVEACGPSCFKHSVKEMEEARRRATVSPSAKTVDAILNVKTESDTWSPRQETMFAVLRRTFKNDFCKIAEMMNVAIPGSIPKTCKELYAYSFRTAPISPRADTSPNSPKKKRTTRDQHRTFRAVKWSKTEGKVGNTHVYEPCSHSGLCTIENECSCVRVDNLCTKFCRCGDQCRYRFPGCRCAPGLCRTKQCQCFYANWECDPDTCKSCKCDVLDDPTVVTCKNVAMQRGLQKKLVIAPSQVAGWGCFTEEDIEKNDFISEYCGEVISHDESERRGKIYDKLKCSYLFGLNDEMVVDATRKGNVIRFANHSKDPNCMAKVFMVNGDHRIGIFAKRPISTGEELFFDYSYNSYQQVKFVSKERPKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3D6</accession>
    <name>A0A158Q3D6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6568</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3D6"/>
    <dbReference type="STRING" id="318479.A0A158Q3D6"/>
    <dbReference type="WBParaSite" id="DME_0000220801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000220801-mRNA-1"/>
        <property type="gene ID" value="DME_0000220801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000002">
        <property type="entry name" value="39S ribosomal protein L19, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000220801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="32003" checksum="B4100B82C68CF72E" modified="2016-06-08" version="1">MSEKLLSHSGDSIRKRIANFPQIYPDFIPTPIWGRRNALREELERADMIERRMQLDIPEFYVGSIVAVTLSDPNTIDRKNRFLGICIRREREGLKHQFTLRNVIDGLGVEIMYEMYNPTILKIETIRLEKRLDDDLSYLIDALPEYSRFDIHMEPVAHTIGKPVPINETKVQMRNPPWSRRWELYDYKGIDFCWPLVNPFFKRKFYQKTKVTDYRKYDLIADKREAGSDLETEWLIEDEMREYDRQRHKRGDTKKRLLYSAADASIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Q2</accession>
    <name>A0A158Q3Q2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Guanylate cyclase</fullName>
            <ecNumber evidence="3 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS108</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 16"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Q2"/>
    <dbReference type="STRING" id="318479.A0A158Q3Q2"/>
    <dbReference type="WBParaSite" id="DME_0000287901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000287901-mRNA-1"/>
        <property type="gene ID" value="DME_0000287901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="716"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN50135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000287901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1273" mass="145701" checksum="17D163D103C4EB33" modified="2016-06-08" version="1">MKFIEKIKFDYIFFFLLAIRNTQSRTRKSKPYTEFPINIVVGLPSNEGNVFRNPFRLTIPKSQPVFDVAIDDIYSIYRLLPEKSLSISYVDTNLSDAIGPQRIIERYCDRTMDAVMGMSYVYALAPVARMSQFWDKGVPVFTTSAMVDELGDKKQFPLLTRLMGTYKTIANTVLQIVDRLGWTHCHFFFHDESANRMVLGRSECFFSLNAIKNAFNQKRKVVWTVNMFDERETSQQRYKEMLITASMKTNVIILCASPDTVREIMLAAYELGMATSGEYVFINIDVSTGSHAEKPWIRANETNSPENEKAKQAYRALKTISLRRSDLDEYKNFESRVKERAEKKYNYSAKNGKEYETYNYLQMNNFISAFYDAVLLYAIALNETLTEGLDPRNGHNITSKMWSRTFVGITGNVSIDENGDRYSDYSLLDLDPQQEKFVEGVRRQNYSTALASLLIRRGAPSGGSWLQLEVAYYSGASNELKQVTEFHWVGGRPPKDSPICGWDHSKCPEGYPFYVYLLSGSAVFIMVLMSGFIYFWRRYRLEAELAAMSWKIRWEDLNGDESKKEKKKSKRSRKVHGYQYESEALLRTNSRSSIGSDKKSSSSSATRKISAMIDRKFSIFTRKKFSPPLPNRTTDQPIVNHNHANAVRNISLTPYSANNEGVHFKDIDIESAHRRISSPLSLDFDGNSKKKKSLNDDEYEMQTKKSISLRNRKLSFAGLSIKSGGSVETIQMQNNTQIYTKTAIYKGTIVAVKKLNIDPKKYPKLELSRSILMEFKRIKDLQHDHITRFTGACVDCPHYCLVQEYCPKGSLEDILENEKIELDKMMKYSLLHDLVKGMYFLHGSFVGSHGKLKSSNCVVDSRFVLKVTDFGFHQLHALEEENIEEIGEHAFYKKKMWTAPEILRNPGAYPPNGTKSGDAYSFAVILHEMLFRKGAFYRNDEPSPKEIYDLVRKVPGFDEELYRPEIFESALNDDQMEPNLINLMINCWAEDPHDRPDFSVIRKVVRSLNKTNETSNLVDNLLKRMEQYANNLEGLVEERTQEYFAEKKKVEDLLHQLLPRSVADQLISGQAVQAEAFDSVTIYFSDIVGFTALSSMSTPMQVVTLLNDLYMAFDGVVDNFKVYKVETIGDAYMVVSGLPEKHDKHASEIARMSLALLHKVKTFVIRHRPNEQLKLRIGIHSGSVVAGVVGCKMPRYCLFGDTVNTSSRMESNGLPLRIHVSSQTKEILDKDSGFRLVLRGEVEMKGKGKQITYWLKGYKDQNVPDFGPEYAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Y9</accession>
    <name>A0A158Q3Y9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7597</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Y9"/>
    <dbReference type="STRING" id="318479.A0A158Q3Y9"/>
    <dbReference type="WBParaSite" id="DME_0000359201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000359201-mRNA-1"/>
        <property type="gene ID" value="DME_0000359201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="685"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000359201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="740" mass="84188" checksum="E1911B11F53E384E" modified="2016-06-08" version="1">MEVILYYLEFFAIDDAILLAELYNDTARSSDSLYLLAHCFLRGGQKENAYKLLSLNELITPQLRFIFAKCCYDLNKLQEAENVLRMDRSAQLHSIFQGTVVEPFAHALLARIFSESGRIDEALKENRYGLEVNLLSWSAIKTHCELGATDLEKIYPKLNASISSAKNYLKDKTNRVISEDKPVKANIGPIVKELDDKSATFAPKKQRSTLNKKELTVSRRRMDNSIEIRRSTRLFASSQDSENMSAVNIRSSSRTRTGILTGTAVRNSQDKQLRSMNRINEIHVNRNIICVPSSQPPIIDKFTESNDDLSDASMNLKPIVSKKNCSGSQAVAPLSSHNQNAQEKEQRGVGVIKSISSFSTNPTRPRVQRNPRLIQKPRKSLSPQARNIVPSTLSSIVNDIAYWTPVFANIAESIYHLAQVQSALSHYKIHLALERLTQMPETCSKSALAKELAARVYLEKLDYQKTKEILEEVHRDYPHRTSGMEILSTALWHTQDSYRLSTLASELTQSARYNAETWCVAGNCFSVQKLHDIAIECFERAILLNPHFAYAFSLLGHELLDTDQLDKAASSFRRALLLCPTDYRAWFGLGLMHFKREQLSLSRIHLNRAVSINPHNSVLLCQLSVVEQALHNNDKAMELLERALFISPENVACRFYKARLLYEMHEYEKCREELNDVKLFAHDEAQIFFLLGRVHKKLGNTHLALINFSWAAEMDPRGEQSHHNINEDPYDDEPTPSMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4I0</accession>
    <name>A0A158Q4I0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS518</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4I0"/>
    <dbReference type="STRING" id="318479.A0A158Q4I0"/>
    <dbReference type="WBParaSite" id="DME_0000489701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000489701-mRNA-1"/>
        <property type="gene ID" value="DME_0000489701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="145"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="507"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="828"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000489701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114009" checksum="D3292FFC777108BC" modified="2016-06-08" version="1">MANLVQETFSCIRTVIAFSAQKQTINKYERLTIEHNRMTEQRLTASSIYDALAQVLLTEIIFTGALCYGMWRVEDKKSGRLTALAINMLYMCVTSISIGFHLTGASTARTSANEMNTILEETPNIECNVNRHKESMMKPKGKGAIVFSNIRFAYPTRPDIEVLRGVSFTVRTGEHIAIVGPSGSGKSTLTALILRFYDPNSGSVTLDGVNLKRLNPDNLRAQLGLVSQEPVLFDGTISDNIRYGRLDATQTEINEAARKAEAWQFICALPEGMKTRVGDRGLQLSGGQKQRVAIARAVIRNPSVMIFDEATSALDNKHEVEVQKAIDAASQGVTTITISHRLSTVRNSDRIIVLESGLIVEEGTPEELLAKRDGKFFRMYNDQKLDSLSVIPKAKAKASLAAHFSMAPADFMDPETYRRAWARSSLGAHKRLGKSYSVLSTDRAKLALPVMSKKRSVMDTPLKTNIMEVAMDDKSFDDEFALPGKDTNFNAVWNLIKSYKGGYAHLAIAIPVTILRGFFFLLVCFEVASVLEIATVPEEEKSQQVFITAAVYTALIIIKTMFEAVGRLFIALYGHGFCAYLRSEMFRRILRHGAAYFDEETNSPGRLVHKLMSDTTSLNRILGEKLDLLLPAMICSIVSVSVAIFINWKLAVLCGFQFPAFFLFRLVELRETSKRQRQMAEQEKKATNLATIVLSNMSTIKAYTLQEHFNQIFCDALKPLQKTMKRQSCVSSFVFACQFSFAYILIAVTLHFGKVMMLSNEISPFNYIRVVLLTQFGANFISQLIASISNLSKARVAAENIVNVIKENAVDMNNLSDEGLRPKITGRLALKNVEFRYPSRPILPVLKNLNIKVRPGESIAIVGPSGCGKSSILSLFQRMYNPTNGEVLIDNHNVKSINPAYLRRVVVSVGQEPTLFSFTIRENIAYGLPDDEATEEKITKAAEIANIHDFILSLPQGYNTEVGEFGAQLSGGQKQRIAIARAIIREPRILLLDEATAALDTARTHQELMKAKGIYYEMNQQEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Q0</accession>
    <name>A0A158Q4Q0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9147</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Q0"/>
    <dbReference type="STRING" id="318479.A0A158Q4Q0"/>
    <dbReference type="WBParaSite" id="DME_0000534801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000534801-mRNA-1"/>
        <property type="gene ID" value="DME_0000534801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877991at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="535"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000534801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="824" mass="94771" checksum="F04E5742880348C8" modified="2016-06-08" version="1">MPSLEKMPDTTTTESQQIPSTRESISGNNCDAAQNIISEVASNISRDWKISEVLSSDRTEEVQKNETISNVYVETVGEETTSTSIISELQCRTPIVASKQHQTLTLSTMKSKVPFHESELPSSPTELACYVRTYADEISFLVNEQYCDTSHLCENCYSMRMELERLANKLESIAKSKEVKVKAIHSVTKDLSANEEIEQKLNIHEQLIEEKKRSDELQSANEILSKNLEKEENLRKLKEKELEDFKFLFEDSIIEQSKKIEELESRNEQLMKALQKQGQMSFIEPKQLKEEKDRKLEGSEFDKSIDTEEFTIPNVQVETELPNAKGESDEPGMKLDGVESENTEAIELLNNIVKSGSLTSMQNKIEEILAICQNQSQKQFQNDIMEESTNTVIMNNQKIEAIAAENKNFGTMNNLSYKLDRCCDAIEFQNSQIKALENNLISANEETKKATIVTVLLIEKNSLADENFAEERRLLMRQTVEKALKNYDRIIETHKAEEGEKTDAICSKIFEVMKAIENQKNLFLHTSQNTEEKFFSKIEQERAKWEKTVEIFNEKLTSMVDNLQNDAHNMERKIDGSKLFNEEMIKMNTINVELAKTLKVMEEKYSKLEAEFNIVKQKWQEDLAFSKNKLHKIRQKNGILKKTIQSLEGKLNKSEKGMKEMKERCEEKERIMNERIENFDTDDDDEENMVVAKQRIKLLLLDNNRLGDACDEADEEIEKLKNELENLKAKLANLEEEKCPSSNFEDQTDSFDSAKKHLKPKANWLNLADSLESLKSGQSTTSQQYNCNVQEEMLMDLLNEIPIEGESEVSEISEISEENDYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q544</accession>
    <name>A0A158Q544_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9572</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q544"/>
    <dbReference type="STRING" id="318479.A0A158Q544"/>
    <dbReference type="WBParaSite" id="DME_0000646101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000646101-mRNA-1"/>
        <property type="gene ID" value="DME_0000646101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831138at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF13">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000646101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="965" mass="109035" checksum="C8CA74CCA7BC1A1E" modified="2016-06-08" version="1">MVGVVRRRSNVNGSMPTELELDQGEMALDDSMNFAIANISLKIGDSLVLSKGIIRESTSQGKELKLKIVSQPKAGWIIRDMWDLNNITSIDQFTTKELDDHRIFYVSNPLSNLERDSFSLVACPDAQQCSHPKRIYAAIKKRNVHEPELIRNEVMKIWNSNVARITKQYLYTYDDDTPPEQLHYIISKPINGYVARADQAGKAIHNFSQAEINNSEIIFVKTLNSTSAGGFSFLLSDGLHQVGPEWFTVESSRIVSVALEANARLIVPPGNVPSVIGMDLLRANIPDISPENTYFSISKLPKLGTILRSGQLVQRFSQGDINNRFITYKPLNSTMQGWVNKDWFQFVVSCNGSTKPIVEEYRSSIAINESYINLTKLNSLCNDSLIIEIARQPRCGSLDFTAQMNGSALKASALITGRRLIYRQWKDAEAQSDDLLFHLYPYETNKRTSRMRIPISIVFKPISDPFLQVVSMPERLKVVSGGETQLNPKLFQVNHPHLQPSAIVYRLLQAKFVDGSNGVELIMADEKIRDFNQGDLNKARVSIRHKQRFDSEDPIDVLVMQISDHVRAIIVDIHPLSLSLINHSDITYVQGRLYTVLDRSHFGAYSNGDRSRIVYNITKPPENGTFYWVAGEMETRSFTQKDIDNERVLYAQINMEAYQDSFEFALGNDQNGVIRSSSRVVVLPAVKSQKLVVESGSQEIITALHLNASKLEGMSPRFLVITAPSYGRLLLDGNFNGSVFFFTFADINSRRLAYYATDSGEELADSVELQLDADGIQPARFRFDILIRPANRHHTVSPASRSITPTIPEVPMVANGISSVGYQLPILVLLIILSLTVFILICCKHNNKRKRKKAGEEDKKRNFNAKLDSVIEEQPDLLDSTVYATVKRNRLELNNSQRMRPLQTFESPQCRVKPPPLPSSPLVQRSDRLHGSSLDYEPFNKATENAKTRVEKMRTTRLRENQYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5B8</accession>
    <name>A0A158Q5B8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS1537</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5B8"/>
    <dbReference type="STRING" id="318479.A0A158Q5B8"/>
    <dbReference type="WBParaSite" id="DME_0000695801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000695801-mRNA-1"/>
        <property type="gene ID" value="DME_0000695801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="54"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="15">
        <location>
            <begin position="826"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1334"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="15">
        <location>
            <begin position="1484"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="14">
        <location>
            <begin position="1634"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN51564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000695801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1945" mass="225637" checksum="8CDC1C86D83C3964" modified="2016-06-08" version="1">GDYVWIESLPNEQYSCPVAAKVVNDHGKVKIIDYFEEWLTPNRRMRLMHATSIQGVEDMIQLDDLHESSVMRNLYIRYSQKLIYTYTGSILIAINPYMDLPIYTTEHIRLYRNHRIGELPPHIFAIADNAYNNMRKNGNNQCVIISGESGAGKTESAKLVLQFLAMISGQHSWIEQQVLEAIPIMEAFGNAKTIINGNSSRFGKYIDIHFNNSGSIESAQIEHYLLEKSRIVSQANGECNYHIFYCLIENLSAAEKNELNLKTVGDYYYLNQRKTLKAERHNDVLDLAEIRSAMKILMFRDSEIWLIFRILAAILHIGNIKYSDSVSVHCVAKLLQLDVRSLVDALTTRSLITRGEQVITCLTPEQSLDVRDAFAKGIYGRLFTYILNKINDTMYRKIGILDIFGFENFSTNSFEQLCINYANESLKQLLIKHIFKMEQGEYEAERINWKKIRFADNEDVLNMIAISPMNILSIIDEESLFPKGTDQSMLDKLHAHHQKKGSIYIKPKSNLNKSFGIVHYAGTVIYSSKGFLEKNRDIFSSDLIALIQNSKFKFLVSLFDSDLPYDAMASHRRRQTTVGNQFRKSLESLMTQLTQYEPHFIRCIKPNETKHALIFDRNLVSKQLRYTSMMETIRFRKTGYPVRYDYVDFVQRYRMFVKEIGSPNKEDCYIVAQKICRSMFDADVDYQFGATKIFLKENQDRYLQQEHDRMLNLHATTIQRTVRGWIDKKRFVHMRMAAIIIQRYWRGYIYRQRYKQIKIGFTRLQAVLRSRQLVLHYKGIKEIITRESISSKISFMNGDIENEDLRGYQFYKFAATYFQRQATAEHIKKILRVPLLPHVDANDHLASLAVWVIILKFMGDLTEPTYSPTNSVDSVVSVLITIIICEISTKEWISLFLETIENYIPYDSFLNDHSMTNLEKLHFIIGHGILRPDLRDEIYCQICKQITNNPSKNSNARGWILLSLCVGCFAPSDRFIKYLYCLIRENIPLENTSYSYYIERRLTRTIKNGTRQQPPSYIELQAIKLKRPIVLAITFMDGSVKSVEADSATTAKELCNALCDKLGLNDRFGFSIYIALFDKVSSLGSGSDHILDAISQCEQHFREQGQQEQNVPWRLFFRKEIFAPWNDPIQDAVSINLIYQQIIRGVRYGEYRSTKEEDIALLIAQQYYIDHGLEMNIEKLESSLSSYVPVEEWKNAVDSNNEQRWLQLVLHAYRKQFSQNQSSREQVKQEIANFAKNKWPLLFSRFYEAYKINGPSISKNEVVIAVNWMGISVVDDNEQVLLELSFPEIFQYIVKLLFDLLLYCSINDDQYTFLAPNASDIKKLIDYFLDGLKTRSQYLVALQNNPEGSDSLPFMRGDLLILEEGYNGAYTQVNRYVKGENTRTGIQGNIPTNMVHILPTVTKPSKLLQELFLKQINFESPMNQQIALISKRNIFARPFTLEQFAANNFKNIEVNNQVKKVIRFGFSRILSNFRKLLSTLEINQNSEPLRLKLEGKSEPSREAIMGYCAIMIYMGDYPSERHFMDIDLTDQIFRGPLKYEILRDEVYCQLIKQLTDNCNPISEERGWELFWLCVGLFPPSQSLLKEVMQFLFTRPNSIAMDCYTRLQKTLKSGCRKFPPHQVEIEAIQRRTTQIFHKIYFPDSTEEAIEVDASMRASEFCSRIANRLCLKSSDGFSLFVKMNDRVISMPDSDFFFDFVRQLSDWVKQSRPNTNRAFVTFAYQVFFMKKLWINTVPGDDRIADLMFHFPQELPKYLHGYHSLSRQQAIDLATLILRAKIRNDKPVSLNQLATIIPELVPRDMLKAYSCAEWKKQIINAYTGSIENLSPDDAKTIFLKYISSWPTFGSAFFEVKQSSDPSISEQVLIAINKTGINLYNASNKQFIVNYPFQSLSNWTSGNTYFHITTGNLMKGNRGNRLLFETTLVSFFLLSEILSTFHLFNDNLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5N4</accession>
    <name>A0A158Q5N4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1993</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5N4"/>
    <dbReference type="STRING" id="318479.A0A158Q5N4"/>
    <dbReference type="WBParaSite" id="DME_0000784201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000784201-mRNA-1"/>
        <property type="gene ID" value="DME_0000784201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="463"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000784201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="638" mass="72530" checksum="2D47EE732A3D1939" modified="2016-06-08" version="1">MNKIVMVYAKSEGEVTKLTAVVIADSFDRRFSPILAQNKSMGAFKICNIEILNYTFQWIAWTEIQDVILAISNDRKESLNSIVKYWRGIFDSFRLLASPNCVSVGEVIREINGRGLITSDFILIANPATFCSTDLCAQIATFKERRRDRKNVLTLLYTLSDTVKPFIVIDPITMKLLAFHHDDDSYKLEFDKKNFLEKDKSIRSDLEDTGIALCSASIASQFSDNFDFQHRDDIIRELLARISTSIFFQLIHLHLEFGICFLFEIEKIASSIDFFRILSNSYDHLDFSNIDYDDFVRGTRLIAQQWLIPFPNIVTDENYFSYPNNIFISGSLSANGDDDSKINLASVGPNVVIGRKCEIAPDVLLNASSIGEGAKIGHYLLLSLCKRSGTNISMSAIGESVLIGNSTKISCSFIGDAVSIGDKVTIEPHCVIGHVGCILRFADEKDFWFACKYHPKNGSSYADEDLQTFEDASDDELNIIERFFEEVKESMERIRGVKFSDQLIKNLILEINSSKLAYNISVDQVAYYVFLAFLHIHRDSSFADIRIISYKWKTLFTNYYKPVKNQIQALAAMEEYLSTTPNFKSLLAKTVHMFYESDIIEEDAILSWYESVDSNSSIYELVKPIVSWLKEADEEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q668</accession>
    <name>A0A158Q668_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase-activating protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2963</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000092">
        <property type="protein sequence ID" value="VDN52990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q668"/>
    <dbReference type="STRING" id="318479.A0A158Q668"/>
    <dbReference type="WBParaSite" id="DME_0000922601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000922601-mRNA-1"/>
        <property type="gene ID" value="DME_0000922601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01249">
        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11882">
        <property type="entry name" value="SH3_GRAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000006">
        <property type="entry name" value="Rho GTPase activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="244"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="368"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="595"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000922601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="654" mass="75409" checksum="9F6AE1B8383E0563" modified="2016-06-08" version="1">MVLQPLEFADCLADSPWFRQNLHEHEVILEETHKNIKTIELLCRDLVQCTRKLSAVQRAFAKSLKEFKFTVVGNNQTDDERKISECLSKFADFVNQIEDHREKIVEDSETHYIEPLKKFRIDVVGRVLHEDKKRYEKESNKFYASLEKHLHLSTARKNDFKEADAQLDIQQRNFWKSSLDYVTAIQSAQERLKFEFVETLSSFLYSWLTFYHVGMFNIYFGFIVFLVFQTQNLSSENQPGSNLTSIKQGYVFVQEKSKIPKTIGRDVLSSRWTMYYCVYQKETRIFTMIPSNSSTKTDMRGALGQSVSFKVKSCTRRASDTIDKRFCFDILAVNRTESLTLQALSEEDRRQWLDAMDGREPYSFKILAVLDDMGFDFIGKCLEIIEQKGISEQGLYRNCGVSSKVQKLLQSGLDKRKIIRKASTIDDVEWEIKTVSSAVKTYLRNLPEPLMTFDLHNNFLNAAKMDSVKRISHIHYYVYQLPKMHFAMLKMIIMHLKKVADHSDENLMTIGNLGVCFGPTLLRPKEETMAAIMDIKFCNVVVEVLITNCDLKCLEDYANYYKAGVTVNGLGVNEGSGHLLDFRIENNNRIIGNIKRARRVKTLYVCIAGHDTELSFQPGQIITNVYESKEEGWLVGTLNGKTGLIPANYVEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q670</accession>
    <name>A0A158Q670_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-lactamase-like protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2974</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000093">
        <property type="protein sequence ID" value="VDN53001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q670"/>
    <dbReference type="STRING" id="318479.A0A158Q670"/>
    <dbReference type="WBParaSite" id="DME_0000923701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000923701-mRNA-1"/>
        <property type="gene ID" value="DME_0000923701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000017">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000923701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35605" checksum="A9A478A4FE3957E1" modified="2016-06-08" version="1">MFKLLRDFIEYSIAILAHFYAHMFRPNNKSLTTIENLNQLSPLVWRILGANPGPFTLQGTNTYLVGSGKSKILIDSGEPNVPEYINNLKKALGENKISCIVCTHWHRDHVGGVPDVIQKVIGEKVPVYKFKRDDAVEDSSCYTFVNDEHILSTAGATLRLIGTPGHTVDHMSIYLEEEGSLFSGDCILGEGSTIFENLHSYMTSLHKLLNLKPKRIYPGHGPVIEEPLEKIGNYIEHRNKRESEILEAFKQSDSPLSMMAVTNIVYKDLPIHLKMAAINNVEHHIKKLLKEEKIEKIGLSGYRLLAVEPQTSRMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6B9</accession>
    <name>A0A158Q6B9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3292</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000120">
        <property type="protein sequence ID" value="VDN53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6B9"/>
    <dbReference type="STRING" id="318479.A0A158Q6B9"/>
    <dbReference type="WBParaSite" id="DME_0000964201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000964201-mRNA-1"/>
        <property type="gene ID" value="DME_0000964201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000964201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="720" mass="80495" checksum="4956CA06CDF969ED" modified="2016-06-08" version="1">MILRQGVDSDRLACNVHKCSNVPRCPDCKLIACTTGFEVLCASGDVDAVSKSDPFTIESLGDRGINLQSSYHGIHIVSEVKIHSPADICGKIDAGDEILQINDETVVGWNIGQVAKLLCSGGNAIFNQLVLIIKKRPSEMTQSSLFARSRNAELQQILHQKTPNSLLKFSSNSHRAAISLLFDNCDLLISDKLCVEDARIRRRALSLHSQASIFGPLQSEFSILNPSVVAATSRRATISCGTPPAILFNGRNISVDDLLQVDAKDMLSNISETYKKLDDCCGKSANININAPELTIISREGRLMRHQHLGYVRSFIDNQLIVENLIDHISNVQSIDEQLVDNFVISLEPDEYATIGIVEAHELNEMDLPSSNLIDWDSCLDLRITIGCKNCVDSLSPVFLEKEVSGYGFRRRSMLELQIFAIHLHVFHDFVAAFDAIDRAAIWSVTLRCYREDHSAHKGNYQRTDYNNKHHDDGEIITVSKHNLTESINLNTCKKSDCSQSVGAINAPIAEFDESGSDCMSDSESENHFPSINNTENITASNEPNLLREMARIPYYSLNAKTCEGWIHRKRFAHETSYRGKWIKCWMVLCSSVLFIYSNKSAPNADIIIAVANFFVSDAPFLKTSKKHWMNKLGLATICYNQTEEERNNSTNLSRSMLYISTFSESTYSLLFAETPPVTPAHYILPRPSNLKLSTRRHFRDPRQASISSLRSIVSNKGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6M9</accession>
    <name>A0A158Q6M9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3984</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000238">
        <property type="protein sequence ID" value="VDN54011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6M9"/>
    <dbReference type="STRING" id="318479.A0A158Q6M9"/>
    <dbReference type="WBParaSite" id="DME_0001055401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001055401-mRNA-1"/>
        <property type="gene ID" value="DME_0001055401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF160">
        <property type="entry name" value="PHD FINGER PROTEIN RHINOCEROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001055401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="650" mass="75270" checksum="11F71A8DBEF49E8A" modified="2016-06-08" version="1">MRNAKVAQREKILRRGRTSNLELLLSMRGKGHKFTHKKGLRNNTTINYGHVEENLKSFDSQISSIKNHKKKSFINEYYNEMLDEEIRLKKKKLFYVTSGDQPTELYRTDFLNRMKQEQNSDSSSDEDDNFVPISDRWKEDWNYGVQVPLHKKLPEFVISDIPCSSSSKSSRSSFEMADKLISVYGRKYIADRHKRIKVPRFFYYQGDAMDLVFLKKLNEKRRNIGFPIIAEVDYFKILNEFEVSCYKAIHYDLLIPLMSPANNASMNVEFDEDTCCDICRQPDYEEDDKIIFCDGCDVGVHQSCYGLDIVPSDEWLCKACTSLGCQTLPHCILCPVRGGAMKCTADGDSWAHVVCALWVPECSVHACINAFHVCCAFRNSQVMAIECSNGEGCQVHMISLCKKHSEELNYFRNGYNEGMLERCISPVTIQCIRDGRLKEMENFFFLFVSPEEIAQKLGIAEEVIDDIYEYWKLKRSEKDNRPLLACSCEIERNITNDLHCQTPSSVLALKLRNEMVLRQNLEQARNLCYMIRKREKLKKSYFSHLVQTYSYVYKQLSSSPVPLSNRALNRFCEALKTMINFNTDCCDLNYQILLNNKSTKASKCIQNIIRERNGPEHTRRNGIERNGFMKSIYQDNYAVLGRGVSKISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPN0</accession>
    <name>A0A3P7PPN0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPN0"/>
    <dbReference type="STRING" id="318479.A0A3P7PPN0"/>
    <dbReference type="OrthoDB" id="27041at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="202"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="517"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="7">
        <location>
            <begin position="202"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="111095" checksum="ED898B2BE4D2E292" modified="2019-02-13" version="1">MYSDPLSDCCLSGDFNILQFLEENDATVDSTLESIRQSAQNNQHCNVIAAGMMYQNPARLPDSPPITDISGAGSSGSPSSTVESPYSPPETYQNYQMVHSNQNGSSGLILGVHPEIPGHMLIPQEMLHQNNANSNNNNGNSNNSNRVLQHTLPSPQPDYIGSYQPQSSQATAISQVSPPSVNIRQVANSYIVQNNGYHHVDPYSNIINSTTNDANLGPQTSDQPFSRKRLRTDPSPHPPTPHIKNEPQKIYTLPNQLTVVPSPVTTDDFEDAFHQQAIKFSRFNEDHWATLYDINQRPLHQLEMHVVADKGFNYSTMDNCFVNQKKNHFQISVHIEAIDNHPPNYVKIGNELRVISEFKLAFCGVKSEMPSSEIQIKQSTTDRRPVPHDPVSLEIHERRMTKVTVPRLHFSETTMNNQRKNGRPNPDQKFFLLVVRLIACSTDGHEAIVQAYQSEKVIVRASNPGQFEPPDSDATWQKNGSTLYYNNGSVAIGTDRALAPLTVGGDIYCSGVVHRPSDRRIKEAIHEVDTKDAMSRLSQIRVVGYSYKPEIAVQWGLSEENRHRVGVIAQELAEILPDAVTDNGDFLQVDDSRIFYETVAAATELCRLTGNLEHKIEAVEKLSHKLAKLHRRKFKDVGSLASGLSEFGIGDKSFMSSRTSLESSAPSCISRDKKCYRSDRERSGQRNLHCKNPACQQYDSFLCNSKFTHATILSLVVVMAVCLIAMSTLYVLDWHHRTFGYMNNFQLTSETPQPEQKIGNIVQVNHGHWIPPIQPNAPPITVNCDLSSCHTYCCTDADEFYAANEYHKGIVNTNFNLPIYQSGLIPRLPIKTMPTAIQSPLASGVNIEVLTVNNFTIDERYCIEDSCKPRRGLYTLYVPVSPLMPTVPLEIKINTADDKSYVDSCGTLRDFAHKACTLYHHSTRFDPNKISNSRKITDDIFEISVGDFMQSAYRFRIGYSTESCSMSESQRGRSFDEYNIVFYRQCQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYK1</accession>
    <name>A0A3P7PYK1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase_M13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYK1"/>
    <dbReference type="STRING" id="318479.A0A3P7PYK1"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF192">
        <property type="entry name" value="NEPRILYSIN-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="95"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="548"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="87431" checksum="6F9AA4FD0318866A" modified="2019-02-13" version="1">MYGFSRLEVCLIFASLTLLCFLIGVCVLWLLILDGYRQIIDGSLFSSRFSSLRTIEKPFAFDKMAIHHSGIVCTTRECALIAGFLAENLNDKVNPCDDFYEYACGNYPLNRHLPSNKASRHTLSDMQTRLYKQIKQILEVSLNDEEPWDRLAKQYYEKCMEEDIPKWKGIQALRGLLKLTGGWPVLEGRNWKSWPHNWTKQLAIMFNKTGMNAVIMELAVTQDPKNSSRNVIELDQPKWGIGSRWPYLTGFHDQTIQNYLSLMIDTATNLGADRKIAENDMKEAIEFELRLVDFSSDEMIRRDPERSNNPYQLWQLSNAFPFIDLEGYIREIFDGIVEISPNDTVIIREIEYFRSIQRVMQSTNKRVIANYLQWRTVQGYSSFLPEQIREPFYAFKANLTGMPSSPALERWEDCIFLSLMIMDIPVGKLYIENFFNEKQAMNKMFELTTYFKNELVTQLNNVDWMDEITRRKAIIKAKHVQYKSGFPPYIFNKTWMNSIWGHIEVHSAESLIQLTIKIKLARIAEELSRFKKPVDRSIWFQSPAQVDAYYAPNLNEMIFPAGIMQFPFMTIGVPNYITYAMVGAVVGHEVSHAFDDQGGRYDELGNLHDWWETATAKKFHEKAECFIRQYDSIKVEEVGIHLNGRLSVGENIADNAGVKTALMAYKSWLKDNSASEASLPGFQNFSSEQMFFLAYANNWCSLIRPKHYVQLILADVHAPNKYRAIIPLRNSHEFASAYHCHLGSPMNPRKKCSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q9S5</accession>
    <name>A0A3P7Q9S5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA (guanine(10)-N(2))-methyltransferase TRMT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>guanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43128"/>
            <dbReference type="Rhea" id="RHEA-COMP:10355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:43129"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the heterodimeric TRMT11-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit TRMT11.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q9S5"/>
    <dbReference type="STRING" id="318479.A0A3P7Q9S5"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="319" mass="36801" checksum="BAFC0B714AA4465E" modified="2019-02-13" version="1">MALSFENSHVNLKNANINFIFIEENDKSFSDEQIFYFGKLIGFGQSHLVQKYNLQERRYIGNTTMDPALSFIQANMVKANHGSLILDPFCGTGGLLIAAAHFGAAVMGTEINYQVARAVGKSSRMGQKFLTDDQSIAANFCQYSLNDRFMGVLLADASKHEIWHYNNFGFVDAILTDPPYGVREKIQKIGKKSRKDHYFGRRYPEKAKYEISSSFLDLLNLAARLLVVKGRLAFWFPSIERELVFTFFYFPNDLIYFNQSEAIQARNENQNNGVKNYKDFTRKQEIILILYQCLFSFSFFYSAKNRKFRILSCYLNMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QBX1</accession>
    <name>A0A3P7QBX1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QBX1"/>
    <dbReference type="STRING" id="318479.A0A3P7QBX1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002048">
        <property type="entry name" value="Septin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="79"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="406" mass="46552" checksum="BDDFD5309F110E13" modified="2019-02-13" version="1">MQAPPNPPPPVPNHLKSPLKLFNGNEMNNMRADDVTKKLDLRIGSDISDSAENIRTLKLNGHVGFDSLPHQLVRKSTKRGFQFNLMCVGETGMGKTTLIESLFNMKIEFPPCNSELKTVELLSKTYEVVEGSIHLKLTIVETAGFGDQLDKDKSAEVILDFINQQFEKYLMEELKIRRCLDYFDDTRIHACLYFISPTGHGLKALDIVTLKRLAERVNVIPVIAKADTTCKDELIRFKSKILSELRNHNISIYQFPTEDETVRAINTELNKLLPYAVVGSTDFVKKENGKSVRARKYPWGIVEVENEEHCDFVKLREAVLRTNVDSLRERTHKILYEAYRRERLRAMKVGDGETGPKMLETFAKINLRAKEIGEIYIEEMKRIDSQIHTLLEEKSKLETKAKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QQI1</accession>
    <name>A0A3P7QQI1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PTPRJ transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QQI1"/>
    <dbReference type="STRING" id="318479.A0A3P7QQI1"/>
    <dbReference type="OrthoDB" id="5830925at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTPRJ transmembrane" evidence="1">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="207" mass="22986" checksum="E7AA7FAA1B495BCB" modified="2019-02-13" version="1">MNVDATAKDIQAITVIDRLIGGLSYQFDVNAVTEAGEGGRSASSFVLAKMPILAPPRPTSKIEVLHETITSTNLIIRFSTAMFNTKNGLLTKCALIVCEVNKNIYGKWVVESWSNRTVTWGQASKYDIWPNYIAVEKPIEPVRIFLPNFISETIGIDNTCKNADPEIICNGPLKPATSYRFKLRIYTAPSLWTETELSEVAVTKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SK60</accession>
    <name>A0A3P7SK60_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1772</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SK60"/>
    <dbReference type="STRING" id="318479.A0A3P7SK60"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="94"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45484" checksum="714A66CD28A298D4" modified="2019-02-13" version="1">MLCIVCGDQATGRHYGTIACNGCKGFFRRTIRRSYKYTCRFSNSCNIDKHNRAVCRACRFMRCINAGMKVDVVVCSEFSIQSSSLSQKLNSWDNPKSLLESLLVSENKIKNLRETVIKQTGSVKYTLKKECPKNMDDGKRKATVNDIFLSIHSQLLLVIEWAKTLPPFAVLSSADQAALLRNFAGQHVILCVAYRSKNNSDFLKLINDSCIPRFHEMENTEFPENFYLRDCERVLDELVEPMRFLKVDDIEFVAMKACVLFNPVAKGLSKNTVMHVLSTRRKIFNALESYLVNQIPQDPNRLGDLTFFILSPLQSLAKMISEDILVSKLSGVAHIGKLMEELILADSDEQKLPHRLQNGVLLISISTSTNLIAISKYKTAFFIKVSDNILKIDEISIFHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0R0</accession>
    <name>A0A0N4U0R0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4507</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DME_0000014701"/>
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    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="8">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000014701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13570" checksum="D6D695C84D25255A" modified="2015-12-09" version="1">MSFKIIFLLNCRLHCFLHFKSDGFLCIDIEILQTIEIENLPRALRRYAKQVDELNLIRIKEIFAKNFKNIRALVALLILAISIYFYTILAVKQETFLEEIDQEVAEEMDTKTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1E9</accession>
    <name>A0A0N4U1E9_DRAME</name>
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        <submittedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4786</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDN54813.1"/>
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    </dbReference>
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        <property type="gene ID" value="DME_0000042601"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000042601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12415" checksum="1C8661E54728FE87" modified="2015-12-09" version="1">MAPKKIATNKVVSANDVGPLTIEDLRMQLASINEKYEKQQGLILHLTRSIEVLTKPPNISTEQILQTIDEYFEKKEKEPCLVGINILEKSSDDETAIADRLLAKNIVAVAGI</sequence>
</entry>
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    <accession>A0A0N4U2R6</accession>
    <name>A0A0N4U2R6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ski_Sno domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55377.1"/>
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    </dbReference>
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        <property type="gene ID" value="DME_0000099001"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="VDN55377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000099001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55852" checksum="89DEC507A6A11808" modified="2015-12-09" version="1">MKMGRATGDFLLSTQTEGLMEGFIPSEEIGDAQRVVLECNGMVEGISYTAIPVDILAAAGVDVENVSELTENQVNAALALAGSSANTIAIPSVSRQIPTKRVRVPTTQQNPADNLTMFIAEDGSLKLTSSSQQNFYVMFSHDEIFSPEQLAAHNIDVNHLSEETVHRIIQIAMPLIDMYKREYNLLLFHSGFFFRRKANETKRRKLGPNLCSTEQGQSVFNGVASIIPPDRLGLNPHGPSLSPSKVLASMDHGSEHNFSIVGEEVHVKKGNRLVPAIVRYCRTGGEFKVQFADGHFEWIGEDHLQFNGNFFLLIFHLHFHHIFVDYYYYVHLEFFFFEGIKVTSKEPSGEEVEPNFFCLVCDRKVYQKVRLKFSKHFFVLVKSFHYITKIFIQEPQYLVIRVPACDACTKRKILILDTEKADCSVQTSPLIELDSFNVNSNNYLSEQSTNPSPYFDDEAKINDQSNNIKKKMSQISLTVDSSFSASEVEQNVSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Y3</accession>
    <name>A0A0N4U2Y3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5424</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Y3"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Y3"/>
    <dbReference type="WBParaSite" id="DME_0000106401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000106401-mRNA-1"/>
        <property type="gene ID" value="DME_0000106401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000106401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10638" checksum="865136205E3C8FE7" modified="2015-12-09" version="1">MPRRGFAFVSFNDPNVTAQLAKMRDFVVNGVSVCVTIPTPRKRDYDPPPRRMVDPFSSGYGGYNDYPPFGHSGGGRGPYPPKRRRRGEFNDSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3T7</accession>
    <name>A0A0N4U3T7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5760</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3T7"/>
    <dbReference type="STRING" id="318479.A0A0N4U3T7"/>
    <dbReference type="WBParaSite" id="DME_0000140001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140001-mRNA-1"/>
        <property type="gene ID" value="DME_0000140001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1910803at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052792">
        <property type="entry name" value="Thioredoxin_dom-contain_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="160"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="65908" checksum="917E1F0FE432A8FA" modified="2015-12-09" version="1">MSFMNDHYSQHKRFNTSNELAQENYFIGKTEERINIVEEELNQPPDDILSSKSFNQYNLIQTSLIILHKMFNIRSLFVFFVVHTLFAVFQSAMAVRFERKYWNMSLTLLLLCKIILCMCIQWLICVYIHMYGYMRHFDQYSLESRWIKESTNSSLIKRSAPPSKQFFPLHIRDYFNGNDSGDLLNYSEIVIVMFYASWSLECYQMRPVFLEVARSFHNNNDLSFAAINCFAPQGECKKTFKANHFPVIAAFIGKIFLVYRGESGADYLRRNINMIPDHERIIFYTSNLISFVIYCTCCCICNNKWILHIRSSMKRLTNKKEITEFLLEYNCAIFSFYPPETDFQQSSSYKKYLYASLYFSQYDHLLGHVGFALITNPKLARFLNITVGQIRLNSCNYTVDYSFNLNFSAIEITTWILKQNCSSHGLQWISPDPELIVKNHQLQLILKQGPTVMLFTKREVLYPHKSHLSLVEQAAIEYSSCFTGNDLHFRLMAQKREISRRRRSSIIKRDKSYCKNMQTYRSGVITCCLLSKKIILSKCSRYDLLNENPGVCPKLNIVRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4I2</accession>
    <name>A0A0N4U4I2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6055</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4I2"/>
    <dbReference type="WBParaSite" id="DME_0000169501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000169501-mRNA-1"/>
        <property type="gene ID" value="DME_0000169501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800408at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230029" evidence="1">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000169501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26732" checksum="B2E0098241A5544D" modified="2015-12-09" version="1">MFLVNIPLTCCFLTAVLTNPALSTPALQYYLPKYALYPPAGEQPNYPAVHPFQKSPKLPPRDDILNYEEVPLVLEPHQQNVKLMVRTSSALHPNNFQNAKLKKSNEERKLFLKSKILSPKTLGSQNRETSLKIPAQPQIAPITNPSHYYLSGANFTNVETPKCAIIRCDGPTADDGSIIFAQYEENGNNSCHQTFVPMNSCIGNKGYPVGMVCTICCDCTSSFVSEMHQTRGYKEGFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4T9</accession>
    <name>A0A0N4U4T9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4T9"/>
    <dbReference type="WBParaSite" id="DME_0000182001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000182001-mRNA-1"/>
        <property type="gene ID" value="DME_0000182001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800514at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000182001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12759" checksum="C69B4225EC5598B3" modified="2015-12-09" version="1">MNELLAILVIVIICCAMFFAWLASMATCPDAIVDFISGKRPSEYSSSSRNSKEFANQDHEIKVLSTYTSPTYLQLNNTKKISESKKLSIVSEKDEQLTIQSDQSNAVQSTSLTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5J3</accession>
    <name>A0A0N4U5J3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6479</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM TET family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5J3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5J3"/>
    <dbReference type="WBParaSite" id="DME_0000211901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000211901-mRNA-1"/>
        <property type="gene ID" value="DME_0000211901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76445at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034870">
        <property type="entry name" value="TET_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23238">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000211901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="33406" checksum="2C03E50B1E8BB77A" modified="2015-12-09" version="1">MVLPQASYLCANMILEHRGTRGNYDAPMQDDQVEVRETVFIQGIPISANEQFIHDVFSTQGDIARNEHTGQPRIKIYTDRETNQPKGECTITFVDAKTAERVINIYNGQTFPGSDQQLSLSFARYKSDSTRGPSRGGSGRGGFGGERTGFGGDRGGRQSFGSDRGGRGYGDRGGFGDRGGFGDRGGFGDRGGFGDRGGRGGGRGGFGDRGSRGGRGGFSGPRDDFSVAHDDFAPGRGFGGRGGRGDRGGRGRGRGTGANMEKRPNDWGCESCGNTNFSFRQECNRCHTPRGGGVSFGPMPRGAMGGGRGGGGGPPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6H9</accession>
    <name>A0A0N4U6H9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6891</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6H9"/>
    <dbReference type="STRING" id="318479.A0A0N4U6H9"/>
    <dbReference type="WBParaSite" id="DME_0000253101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000253101-mRNA-1"/>
        <property type="gene ID" value="DME_0000253101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF18">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000253101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25780" checksum="A4F71F24D3E4BC98" modified="2015-12-09" version="1">MIIIGDNGRPNDFPDSRIHWIFGCFGTLSVLANIMFLFLPKHKLKNCIESVQMANTLKSFLNRKVLLLSFSWIHLGIFTSFWLGPFPTSLLFTNSLNNEKNLIPLYACSLAIGEVIIGFITSYFATKIDDFGQLPTALIGFTTNIICFLLVLISIPCNSTLFPNEESALLIEPKLFFFYYIALFCGFLLGIGDGCWNTVRCCIITALMPKRRAYGFCISKLFQVDFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6W1</accession>
    <name>A0A0N4U6W1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7050</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6W1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6W1"/>
    <dbReference type="WBParaSite" id="DME_0000269001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000269001-mRNA-1"/>
        <property type="gene ID" value="DME_0000269001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000269001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19067" checksum="0F7C177C66D7749A" modified="2015-12-09" version="1">MTYQAVLELKGEPPKRFCCISNPEDPVNGLIPLEYGTQSKPIQVLDSKTLRIPKFIFDGSKPPDAWIFVGKGHLDKEKGRRALVLGRDTWQHHCPLRENYDGSRDLIVRLPDPFNVYDLNYISVFCYEYAVDFGHITFELSPLRTAVPAYIPPIHLKSPPFGGPQIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6W9</accession>
    <name>A0A0N4U6W9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6W9"/>
    <dbReference type="WBParaSite" id="DME_0000270001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000270001-mRNA-1"/>
        <property type="gene ID" value="DME_0000270001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000270001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9374" checksum="3CD3647623DF2C73" modified="2015-12-09" version="1">MPILRVSSVSVISVYAPTLSADDRDKDKFCAELQLLTKSLTKYDMVIIEGDWNARIDHNAAAIASTIGKYAIGDRCANGGCLLWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7A6</accession>
    <name>A0A0N4U7A6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Rho-associated protein kinase let-502</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Lethal protein 502</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Rho-binding kinase let-502</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">DME_LOCUS91</name>
    </gene>
    <organism evidence="36 38">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35 37" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with rho-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7A6"/>
    <dbReference type="STRING" id="318479.A0A0N4U7A6"/>
    <dbReference type="WBParaSite" id="DME_0000286201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000286201-mRNA-1"/>
        <property type="gene ID" value="DME_0000286201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000047">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000072">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18 27 29" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="285"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="33">
        <location>
            <begin position="548"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="34">
        <location>
            <begin position="1033"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="32">
        <location>
            <begin position="1328"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1431"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="636"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="885"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="1122"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="1455"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00053856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00079005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="VDN50118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="WBParaSite" id="DME_0000286201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1467" mass="170738" checksum="8E49BE8CCCE62177" modified="2016-06-08" version="2">MTRTLNQLDKLIASPIRNKEGKEESVMAEALMNVSSTKEGGSVTFPHERKQAVQRIPGTSTLPYPGSPNKTRHSVFSIKTIWPSDIERRMETSKLYNFKNRQGRKLLEKTLLTESDSESGGETTFGMHEIRILMKMHRRRRKIQKCYPTDYTNSQYAYIGTGVFSVYDRFPEHQASILKQKRFPNTANVSNVVRLIHENVKNQSNKMDFFPVFSSMEDGVELSDHLLNPRSLLNVDGLLDALIAVVEDCSYPLLRKTTKNIENFVSRYQEAVKQVCHLRLKGSDFHLIKVIGRGAYGEVQLVRHNISQKVYAMKLLNKSEMIRRADSAFFWEERDIMAHSNSEWIVRLHYAFQDSRFLYMVMEYMPGGDLVNLMTSYDVSEKWARFYTAELVLALDALHCMGFIHRDVKPDNMLISRSGHIKLADFGTCLRMGPDGLVKSSTAVGTPDYISPEVLELQGTEGVYGKEVDWWAVGIFVYEMLVGETPFYADSLMGTYSRIRNHEKELNFPEDVEMSGNAKDLIRKFLSSSKTRLGKNGINSINKHPFFINDDWTFETICKAVPPVVPELKSDDDTSHFDDIDIKEPDPADNFQIPKSFAGNQLPFVGFTYSNELGPISMICKKLTNGFHAGDSSDKLQNALDELNRLSSLDEKLENEKRQLEKDLTSSLIEIKDLTRRLDMEREEMNLKAKMVSSLEEQLSIKGKAEERVKDLERQIIELTEKCRFHAEGEEKARKLYAEIHTKLNSQLELVRELDERLRKNNEEEISFQEKIEQLCAQNMQERENSRRAQQRLNEQSDKIESMRNEISSLREREMNLKCQLGNLNESIVAQRETLKDENRMVNDETKKNNIRLIGELKSAHKKIEQLSLDWEEESRRRSLAQNEIHLINDQLNNLQSSLEYQENELRRTREEKRRLEVQLQTLSSSNRLLQRQLEDIREQFDTESSFVNIYKIEMNAINEELVEKTRRLEQLEEYQRREEERIREMISQLESERLARRIAEENLSTTDKEKTMLEVEVRQLVQRHEKELSAKDAAIQLITQKEEELQLSLQDSRRELLAISERDLDLQRTLGSPEQKIKDLEGQLEREKMMKMTAINKLEEVMAYRQLNGKSKKEKVSKGDVKRRERRIADLEKDLKLERQKYEERLMHFSKENEQLKIALAEEEKLNESLRIEIEAFQHLEMVMNEQKKRERGTSELPEQFNATSNITPVLSEKDINYEGAVSIRLTIKRRHQWQECFAIFNFSGLFFYLTENDRQPFQTILSEKLCHARHVSAADVRFAGENQLPRIFQIFYGTEDNTSTRSSISDIPIGISGSREEKLDKALWNRHDLIELTFHMPTNCDLCVRPLSNFLRPPPAYECKRCRMRFHRDHLGNETIPQCRQTVDARDMLIMAPSSEACEMWVQHLKRFLDFKHAHKTVREIFRKFSKGSSIPRSGSSMKVPMKPTNVPPRSATLPNNSLNVPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7G2</accession>
    <name>A0A0N4U7G2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS152</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7G2"/>
    <dbReference type="WBParaSite" id="DME_0000292301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000292301-mRNA-1"/>
        <property type="gene ID" value="DME_0000292301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9970237at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029245">
        <property type="entry name" value="DUF4528"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34651">
        <property type="entry name" value="SIMILAR TO ENSANGP00000021391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34651:SF1">
        <property type="entry name" value="SIMILAR TO ENSANGP00000021391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15031">
        <property type="entry name" value="DUF4528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000292301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="19708" checksum="FD0EC895C4EEEABA" modified="2015-12-09" version="1">MQKNIKIKIKVKMFVYYLIILPYRKFLNRSYRCRPLSSNILKIYIRSRSYPSWTSFFLPYKEVQDDFYSEKYFNIDVDGNNYQILRIGCFPFIKFHCTKNSFKNLTFENYFFKFLTVLNFGIPCLLYGIIALFFIKHTEYIFENKTKRKISIHFLIKEDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7K4</accession>
    <name>A0A0N4U7K4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS198</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7K4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7K4"/>
    <dbReference type="WBParaSite" id="DME_0000296901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000296901-mRNA-1"/>
        <property type="gene ID" value="DME_0000296901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008956">
        <property type="entry name" value="PRK12299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="36"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="193"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000296901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42002" checksum="5D7C2AF375B0B79F" modified="2015-12-09" version="1">MLQSYHLSFFSKSLISRYLTKRPLIPEKVNCLGKDSSFIDFKRIKCKGGNGGDGMVSFLRAFNLPFGGPAGGNGGNGAHIIFQADTSTKDLSHLKSVIIAKNGEFGKGQCCHGKNAEHCYIKVPVGTVFKKPSSNTIVADLKAHGSIFLAARGGAGGHGNLFYLSNSLRTPLKAEFGGRGEELDYDVEMRIIATAGLIGFPNTGKSSLLRAISRARPKIASYPFTTLNAHIGIVNYDDYVQIAVADIPGLIEGSHLNTGLGIDFLKHISRCQCLFYVLDPTLSELSDQFKALRFELEYFEKELIEKSTTIVVNKCDLMGKKLNISAIEQIFHPHSVFLVSAKHGTALEPLLLHLRDEYDRNQEQKSKEENLCEPDDKYQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7M6</accession>
    <name>A0A0N4U7M6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7M6"/>
    <dbReference type="STRING" id="318479.A0A0N4U7M6"/>
    <dbReference type="WBParaSite" id="DME_0000299601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000299601-mRNA-1"/>
        <property type="gene ID" value="DME_0000299601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="N-ACETYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538:SF4">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000299601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27303" checksum="984B7E1553CEE0B9" modified="2015-12-09" version="1">MDGRNVSDNGDDRDIYLLVALVDRLDLVSPCIELLNEEWPRSQAARENSLKKTISSKPPMSLIFLDRKLDKLIGHAKLCSIIGDDESCWIESVVITKKLRGRRLGARLINAVEKKASQFGFHKVYLSTTNKYGFYLKCGYEFCEPIFHTGANINLFKGVNALIFLPKNSNSKFEKKNYDFKDIKNNESDHSSNKSSKVNNIPSVHHIPLPPPLPQQSTACRFSADFCSPLKKQYMYKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7R5</accession>
    <name>A0A0N4U7R5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7199</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7R5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7R5"/>
    <dbReference type="WBParaSite" id="DME_0000304001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000304001-mRNA-1"/>
        <property type="gene ID" value="DME_0000304001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000304001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48887" checksum="AB06DEDD4D66FFF1" modified="2015-12-09" version="1">MKQKFLKYSKRAFTEVLRENLLINRLKESNFDLAFSHMYDFCPIGLIYAAKIPTWIWLNSGQIMDITAQYMGVPSPPSYVPPILADFSDRMDFSERLKSFMGHILIPLFQERLLIKPETEFFRKYIDKNFPDLTDIAMSCPLAMVNSNELYNLPRPTLHKIIYIGGLGMKIESVKPLPQKFEEIAKRGKTLAIMTFGSFVNTTAMPKNWKNAFLNSFKKFKEIEFIVKYAGNDLNEQISSNVHLEKWIPQRDLLQNEKTRIFITHGGYNSVQEAIHSSTPMIVIPLFADQFLNARLAEHHGIAYKINKGRVSEEAVTSAIKTVTEDRSYVEKAKRLKKMVTRKPFKGEELLIKWTEFLAEFKSLDNLVPYGTKLNFIQYFSIDVISVIGLTIIIILFIIYKLIMVVLALLKEKFLMKKEKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Z8</accession>
    <name>A0A0N4U7Z8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="14">ETF-QO</shortName>
            <ecNumber evidence="14">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7299</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 14">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Z8"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Z8"/>
    <dbReference type="WBParaSite" id="DME_0000314001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000314001-mRNA-1"/>
        <property type="gene ID" value="DME_0000314001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000012">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="12 14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="15">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixC ubiquinone-binding" evidence="17">
        <location>
            <begin position="255"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixC ubiquinone-binding" evidence="17">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixX C-terminal" evidence="16">
        <location>
            <begin position="520"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000314001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69970" checksum="69A397B98C425706" modified="2015-12-09" version="1">MFWTSRCLFRACAAVRHVVDGKWVTTHYTRRPRKLDERWKEIDMGRSSDNYDVVVVGGGPAGLSTAIRLRQLAMQNNKEIRVCLLEKGPEVGAHTLSGAVIETSALDELFPDWKDSAPVFQKVLNLQKESIALLTEKRRIPIPVLPGNPLNNHGNYIVRLGHLVKWLGQKAEELGVEVYPGYAGQEILFNEDGSVKGIATNDVGIAKDGAPKENFERGMELLSKCTVFAEGCRGHLSKQIIEKFDLCVSSDPMSYGIGVKELWIVDKSKHKPGYVEHTLGYPLARDQYGGSFMYHIEDNGQPLVAVGFVVALDYRNPYINPYQVRMIKILTHVFVFNFGSDVPESIMGYNFQEFQRYKSHPSIRRYLEGGQRIGYGARALNEGGYQTVPKLNFPGGCIVGCSASLLNVAKLKGVHNAMKSGMVAADIIFPELEKQATVNPVEYESTLRQTYVMQDMKKTRNIRPSFNTSMGWIGGMIYTGLFYLLGRGSEFWTLHHVKRDNEITEPAIEHKPIEYPKPDGKITFDLLSSVALTGTNHEENQPCHLTLKDDDVPETINLAKYAGPEARFCPAGVYEFVPRESGSDELRLQINAQNCIHCKTCDIKDITQNINWVAPEGGGGPKYDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U812</accession>
    <name>A0A0N4U812_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7315</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U812"/>
    <dbReference type="STRING" id="318479.A0A0N4U812"/>
    <dbReference type="WBParaSite" id="DME_0000315601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000315601-mRNA-1"/>
        <property type="gene ID" value="DME_0000315601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF215">
        <property type="entry name" value="PROTEIN WINDPIPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039157" evidence="10">
        <location>
            <begin position="17"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000315601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65099" checksum="92F1166A32C862DE" modified="2015-12-09" version="1">MERNFLLMLILPNVWAMCPNGCVCTDNEERETKCNGSQITDLPSLLDPRTKLLSISNSRINMLDADTLELYPELEYLDLSNNEIETLRTGLFRCQNKLLALYLNGNKIARIERGAFTGLNALQVIDLSSNRLSLLEPLSFQEMSNLMEINLSNNLLNYIEQGVFHGLDHLRLLKISFNRLQAVNFEMLAEIPRVQGIDASHNLISRISFAAFSQQSELRWLDLSSNLISAINESSFIELNSIQRLNLSNNMIHQISDINIQQLSSLEVLDISWNSLIALTTSSFEGLSSLQHLNLSHQQYLKEIQPISSYLYLFAFHFASTFSFLQLNAFSGLSSLNSLDLSYCKQLQKIDEHAFEIRSQLRHFDLSHCSLRSLSEALIDWNRLSSLKLAGNPLHCDSNLLSFLPNLLKKLSISDMKCSTPEDVLGWRIDLMVFRKLNSGSSSLNDYNIIKSILDHQFLLIIVSCTTVTAILLVPIFKIYQRMKSSIKKSYKPDLPHNRPAITDTVGYDKRCAFKEVFYSPSEFTASTSSTFEDTDHYTSLMRQDDPYINVNTNRSNERSSIYSQNHQPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8F3</accession>
    <name>A0A0N4U8F3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7478</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8F3"/>
    <dbReference type="STRING" id="318479.A0A0N4U8F3"/>
    <dbReference type="WBParaSite" id="DME_0000331901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000331901-mRNA-1"/>
        <property type="gene ID" value="DME_0000331901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018526">
        <property type="entry name" value="Glyco_hydro_29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00385">
        <property type="entry name" value="ALPHA_L_FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041624" description="Putative alpha-L-fucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000331901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59549" checksum="B356AA759B35241B" modified="2015-12-09" version="1">MSLTLIIFLISLLHSAKSEFSDKLKSAKYEPTWESIDSRPIPLWYQKAKFGIFCHWGVYSVPAFKSEWFWWQWKTARNLAVLEFMRKNYRPETTYADFAHEFTAEFFDANKFREIVEASGAKYFVFTSKHHEGYTMWPSKTSWNWNSVDVGPKKDIVGELKTAFSSAGIHFGLYFSLFEFFNPYYIQDQQKNTSDYVERRSYPQLLELVNIYEPELIWSDGDWEMSENYWKSKEFLAWLYNESPIKDNVVVNDRWGTGVMGNHGGFLTYSDNFNPGHLLPRKWENCMTLDKYSWGFRKNLESSDVRNVSQLIRELVTTIACNGNFLLNVGPNKYGIIPAIFEDRLRELGKWVNRNKDAIFDTYPWMYQNDSVDIWYTVSLPNSNVIRSSLAWTKHTKGSKLYVFFLEFPAKNKVELPSVLFTEQIKAAVLLDNDLSEEIPIIGSKGKPIILNFSSHQRLIRYNQIVVRIENFDAIYHDPIKYLTKHRIIDANKKFQTINIHNVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8S9</accession>
    <name>A0A0N4U8S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS332</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8S9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8S9"/>
    <dbReference type="WBParaSite" id="DME_0000346601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000346601-mRNA-1"/>
        <property type="gene ID" value="DME_0000346601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072532at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052647">
        <property type="entry name" value="Zinc_finger_CCCH-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46582">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46582:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000346601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="836" mass="95123" checksum="7844C3DC4D867E8F" modified="2015-12-09" version="1">MEGCNISSGSEADDSNQDGRGVQFEQISNNEPDVDAELDYDEDNEIYDEMDGIVENYEGLNNMGEQEEKITTGLNTDDLDVVETKQSNMPKNEFKWCAEGDAHMKKCSGDEREAIEDGEIIDLEDGELRSGGESDLDSLSGRRVIQSTFSENHLKGRSRERTPMRSRRIDEPCNLGVCKFYLRGTCTWGPDCKYSHSDENHGIGLHVSNFSSDSNWRCERKNMPRNDRERIKRESIHSRIIYPYETNYGSVGNIDSSGKDLSSKESAWEKGLRQARELMIKASKKREEEPDFDRKRLILTPSDEIDRHSHHTDDDSDDSRYIGRTRIRSPRSPSQRNFTNRSIGGSVGRALAEERRALRYLSDSRNSEGNTRIRERDSDRNSTIYSQISHHRKIPSLIDTLREGRIFEPPKNIDLGPQVLYPSGRPIRRRERIFRRDRDCHEENYILREESRSPRSVSSSRSHSPIRPRRDLDFKDRMDRDVSPSKRRTALGDNTGTLGLGSAEIRDPWERNCVKRGHSREFITATLDPVQKGGRKISRCNRRLSDRSASSSVSQKASSESSFSASSRSSSHEKCHTSSRPSYMSAVPLKNVFDDDGSVRPTDLSSFRIPKRKMPVSSKHRDSSKRNLKRKVGKELVQKRATSPILPKRKRSISRTLKQNTLKNARQSENDLYGCGSRNRSSFVDNREDVSDDSSFSSSSSSSDDTEPAAYRRKRYTAIDDGLPTEGIPLSPEAAVEDVSSDEQDDPAVGNSPNCSSRQLITPSNESAEYFPEKNSKEEKDSIMEENILNRGQSIEIDGEEYIDNEVESERRAELLRQLKCVEEAIARKRSRPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U908</accession>
    <name>A0A0N4U908_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7554</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U908"/>
    <dbReference type="WBParaSite" id="DME_0000354901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000354901-mRNA-1"/>
        <property type="gene ID" value="DME_0000354901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000354901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9888" checksum="008D70BE8457C406" modified="2015-12-09" version="1">MLNIRENCTKLDTQNLQALNIPTSKVNVDFGISQLRVLIVRPFKRELYLCVIVTYLLCFPFKRKPNCSEGMILRHQSVARAHSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U909</accession>
    <name>A0A0N4U909_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">XPA_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7555</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U909"/>
    <dbReference type="STRING" id="318479.A0A0N4U909"/>
    <dbReference type="WBParaSite" id="DME_0000355001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000355001-mRNA-1"/>
        <property type="gene ID" value="DME_0000355001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="10">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000355001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23516" checksum="6272140E831531BE" modified="2015-12-09" version="1">MVNNLSTVFCRKNQENYDDAGGFLDDDDEEEMRREKIAEARQRKADEAAKISVARAPDGCSTCCKPLIDSFLWERFSYPVCNSCRDDKGAHKLIARTEAKRIYMLKDCDIDYKKPILRYISKKNPHNPRYGDMKLYLKAQASLETRCLEIYGSWEKLEELKESRVIQKEVRLEKRFEKKIKDMRKHVGFFFSLSFDRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAC2</accession>
    <name>A0A0N4UAC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin regulatory light chain ef-hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS451</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAC2"/>
    <dbReference type="STRING" id="318479.A0A0N4UAC2"/>
    <dbReference type="WBParaSite" id="DME_0000408701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000408701-mRNA-1"/>
        <property type="gene ID" value="DME_0000408701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000408701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20050" checksum="64FF37E9D50FFF87" modified="2015-12-09" version="1">MAFRKTLNRRPRPQRATSNVFAMFDQAQIQEFKEAFNMIDQNRDGFIDVQDLQDMFASLGKEVTEDFLEKMVNEAPGPINFTMFLTLFGEKLTGTDPEEVVIKNAFQCFDEDNSGFLNEDRLRELLTTMGDRYTDEQVDELFRDAPIKNGQFDYVEFTRMLKHGTKDKDDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAK1</accession>
    <name>A0A0N4UAK1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8066</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAK1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAK1"/>
    <dbReference type="WBParaSite" id="DME_0000418301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000418301-mRNA-1"/>
        <property type="gene ID" value="DME_0000418301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000418301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33700" checksum="C32981F325735868" modified="2015-12-09" version="1">MEDYEKITVVGRGAHGVCRLCRRKDDVFGQKVIVKTISLDGLTPEEETAIMGEVMLLKRLHHPNIIGYYESFRTENALSIVMQYAEGGTMSQMISEQSKKGTSFPESTVLNYFTQVAIGLEYMHSKQILHRDLKTENILLNKKRTIVKLGDFGISREISTFSLASTLVGTPKYLSPEICEGRSYNQKSDIWALGCVLYELCELKKAFDGDNIPSIVIKIIQGKYGSVSSHWSSELHTLIKSILDVNEKTRPLLKDLLTCPLILPVCLSINLDLGSLPATSNKKVQLGKSNSKILRTQAVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAM4</accession>
    <name>A0A0N4UAM4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8095</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAM4"/>
    <dbReference type="WBParaSite" id="DME_0000421201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000421201-mRNA-1"/>
        <property type="gene ID" value="DME_0000421201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837516at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029201">
        <property type="entry name" value="Jiraiya"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15038">
        <property type="entry name" value="Jiraiya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000421201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28971" checksum="1DA3322E3E6F8101" modified="2015-12-09" version="1">MEYYNEPIFFSWLLGLMSALPVINSTPLRAPLARNSSFFSDFNQHSAIPFNRRIHSVKRKMPNEADTNFHKDDLIGKITASRVKFSLLILAFMSISSILFVYIANQKFAIHYPSINNNVYMLPREITSSISYLSLVSSISTFFISAVQLFSALNMLRIDPTSADNKNLGESLLLSDTSGISDPLWFLTPNNYLVVGCVLNSTMIPITIKSAWKFIGISIGLISILICLLSVVHSVYTISFHSESNFSDKLHQGNLSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAV7</accession>
    <name>A0A0N4UAV7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8193</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAV7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAV7"/>
    <dbReference type="WBParaSite" id="DME_0000431001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000431001-mRNA-1"/>
        <property type="gene ID" value="DME_0000431001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF7">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000431001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50600" checksum="ABFE8B37897C116F" modified="2016-06-08" version="2">MAEEEEEISEEEEAEDEEEEAEVEEPEAAPAEEAEDEEKEQEQPEETKRRRPPEEKEKEPAQQTEAELAMLAAKKRHEEEEAAKIQDYEEKRRLEKEKIDEELRALKEKQEQRRRQREEEEREFAERRRQEEERRRQEEEESKARIEAEKRRREEEKRKRQEMMAGSFAGATTTTGGGRNFVVSKSEKADKFGSLAAKQEVSNESREESKKAFIASITRRAVNPADLLPNDLKDKIKQLHSRICKLEAEKYDLEKRQERQDYDLKELHERERQVARNKALQKGLDPDEAAASVHPPKVNVASKFDRQIDRRSYGDRRNLYENPIVKKPPKIAHGTARPPPEWGRRDNEELEQLRKNLEPPKYVEQVKAEGDAARPPVQPIPLSVPQVDEVEEDEQAPPPEPPPEPEPQPPPAKSAAKEKPAPAPPTKRAPPPVKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBP9</accession>
    <name>A0A0N4UBP9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8527</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBP9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBP9"/>
    <dbReference type="WBParaSite" id="DME_0000464401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464401-mRNA-1"/>
        <property type="gene ID" value="DME_0000464401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="92"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38341" checksum="C2B4B7FB5F51622A" modified="2015-12-09" version="1">MYIRSDKELELRGGDTADLYANSADDNESVINEGTPSSSEILDTIKSDVNKDIEESGDNSEQKSDVSESGTFKRYRRSSSSAVTVTTSDTEFNYIFRINVPRKLRRFIIGHNGKLKRKLEEETNCKLIFPSKKNKNHPVELISIKSKESLERCRDRIELIILNAREKAPYTHFVSIPMNYPDIQMTFKQFTEAVLADEELSDSCRNPKLFQGACKLHFTIVMLSLFDKSEQVNAINFLQTVIDERVKNVLDGQPLEIEVKNLSYMSEEPSHINVLYACAYSDKLNDVANTIAEALSDTDFAPRQSGDVKIHMTLMNTRYDVIISYNFIFNNFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ8</accession>
    <name>A0A0N4UBQ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8538</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UBQ8"/>
    <dbReference type="WBParaSite" id="DME_0000465501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465501-mRNA-1"/>
        <property type="gene ID" value="DME_0000465501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000251">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010474">
        <property type="entry name" value="AP3D_dom_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058898">
        <property type="entry name" value="Mu_AP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06375">
        <property type="entry name" value="AP3D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26171">
        <property type="entry name" value="Mu_AP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01354">
        <property type="entry name" value="BLVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit delta" evidence="9">
        <location>
            <begin position="687"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="891"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="942"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142966" checksum="BEF4C8C85784EE57" modified="2015-12-09" version="1">MALRKVRSNIDRLFDKNLTDLIRGIRNNKDNEARYIAACIEEIKGELRQDSVFIKTNAIEKLAYLQMMGYEMSWASFNIIEVMASTKFTEKRIGYMAASQCFYDETDVLMLTTNLIRKDLHSANMYETGVALGSFSCFVTSDLARDLTNDVVNLLSSSRPYIRKRCVLVLYKIFLKYPESLRPTFPRLKEKLEDADPGVQSAAVNVICELARKNPKNYLTLAPIFFRLMITSSNNWMLIKIIKLFGALVPLEPRLGKKLLEPLTNLINSTSAMSLLYECINTLIAVLICVSSGAPGDHTASIQLCVQKLGVLIEDSDQNLKYLGLLAMGKILQTHPKAVQAHKDIVLRCLDDKDESIRLRALDLLYGMVSKRNIMEIVRKLMEHVDAAEGSFYRDELLSRIISICSYNNYQYITNFEWYISVLVELTKVEGTKHGSLIAGQMQDVTVRVQSIRHFSVSQMALLVENANLLLIGSAQHRSNICEVLLAAAWICGEYSEHLRNVQGVLEAMLKVKTLVTPGHILSVYVHNIAKLYALLLSRAEAEEDWDAVDSLDNLMLSKLPEFQLADHLEAQERACTLVAAIRVLESFHAKREKVGEYFAKLFEGELNPVAVKAQRKVPVPDGLNLDVWLHEPELNDSEAEDDSYGQTVDDKINDKYRVEDSQNRFHFTDKVLDKKYGKMGSEANELTEKEIQERRARRLAEIENNPYYMKGDLKPSTTMRATKFNVRESSEKLEPVSTEVQSPLEIPGVLGLNRYIEQQQSTLSWKAAKKEKKKRKEKKMKDFKTISSSSEENITTVHQVNRADGEMPENAKSTDDDEEIENLRDADDDAYKALDMDLEENLKESPPTVQTRPNMLNMRQSSNFSKNDPAACSSCNGTAFDEQRISKIIKKRKEKHNKDDGKYRKKTKGKREASQKSTKNQFSPVRSSQSWVDSSKIASSIEKDHSSDHRRISKSRRLETRMKESKNIQELTEIVEPIDKEIYEITSGVCTPSNPNFGSFSNGAISSGDVTPQRSVDNSWSKLRLNLSSYKLLGESKDLKMMYETQVSTEDANQVAVCVVFTNVNGNTIRQLEINILDTLNTRLITEERQSPTASMLLPFQLPPEISTEHIFRFSVGAINVAQRLRGTITFFVEGNGQVYEDKIDFYIRLPTITFILPATIGSDAFELLLASGDVDFKSSAQFSSSNMWSDIIRKITFFGHFTVVDDHNNYASLYAHTIKADPICILVKRQKDKIQIDGRCGDQQLIYSVVDELREIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBU0</accession>
    <name>A0A0N4UBU0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8577</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBU0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBU0"/>
    <dbReference type="WBParaSite" id="DME_0000469401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000469401-mRNA-1"/>
        <property type="gene ID" value="DME_0000469401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000469401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2051" mass="226850" checksum="56325A438B496578" modified="2016-06-08" version="2">MTNYDSVPITNLQGYCDTARDTILLADQNNIDVYYRCISGFNFGGLGFWQKNFCPLGSYFDFVNQRCQAAKRTNKANFAILNSTCAAGEQCVGGSVCDPQFLKCICPHGTVAQLETLSCILDTTDSGQMITSLQINPVFIPSNNVEQINGQSLQLHLPSQFHQEIGDVKQLKFGQTALPGSDCSHDEQCLGGSLCVYPMRRCLCPGDMVAQNNICVSPNEMRSTAKKGIGSPCAQSIECDYDALCMNGRCLCLEPRYDFKGRCIVRKEVGVGQRCSNGEICTSGSVCDNTEIICTCPFGTILEDGNCQPVATAMTTRPTPMAWISVPTTQASANFANTIFMTMPYHQNQQKALVGMKCTINTDCMVGAYCKGNTDPASCQCLSTHVAIKNICKQIFYPGQNGCEEDMQCSLAYNGTKCEQNQCICPSQFRAVEQTCKPGILLPGSACNSSMDIDACSAGSVCFQSVCRCLLPLVEFQHQCINKIYLRVKSSKRITCKRSNECPPDLKCLNGKCGCTPGTLRRNTLCLKDHRYNLAKFRETMNNVSLRGTKNFVPYEHIRRYDWISEKDCRPNQYKCTGGRCLHGRCWCKKGHIKIKNQCKRISCKDNAECPEDTLCIFNRCTCTIDGCSLMKKGNIGGMQKRRKRCLEDGDCGAGYKCSNTECKCSEGYTKQKLIKSRNYLKINFRKKYNKWTILFSFYLLKNLLGSLLKENGCKKLSGAFKPIGSHCGINDRCAGGSVCTNSTCICTDSSIELYGRCRQKPGGRCADGQICTGNAICALAKCQCPDGYILDGPQCILGVSSPGQSCQQGQKCANGSICMFGVCMCSFNFHIVDNSCKRLNKQGRNDYLETKKTFDEWKDHLTSNLKKPGESCIPSDFCLGGSNCITKMCICNNDEIISNDICIKTDQKVLIDNAAPGQYCREEIICTGGSVCFANNCTCPAGTLLKYGECINDSTTSNNENEFVLPGSICSQATKCHPSTECIRNVCRCKPGETIIEQYCRKALYKVLPGGKCDRKYGLDCVGESHCVGGICKCSSGLENGVFECVAKHNGLLNFNHSLQNPFYLMFESPLFFSQMQESSQLNTAQSNINPELTGMPGDRCTIEGFCWNGARCVNQRCICALGYSPINEACHLKMAKLHENCDITEQCPIYARCVGGFCTCQSSYIASSGYCIRKNLARPGEDCSNGQICGYRSYCDTNSGICECPREFSLNDGECMILLENYKCDINSDCNDYAFCYNGYCICDVAEQKNNQALCLPYYMMSDIEARLVSFAPFHSPHSFTTSQASFEIPVQFENDDGSTDAYDESDLINIGNDLIEMNQDYIDNYDYTMGEKRLIDARNIEQTWMPNMLMSPLAQGNPITQKIIFFNPNRRTAKLLRRKPVGYSKPGEACGTTKICIGNSICIGKFCRCKNGTIKEGSYCTDSNKVNVVYHRRNSVRMPLDRCDFGEKCLFGSICENLGFYGRICLCPTGKYLIDNVCREFLSSHALLNEYCTTRKKCVNGAICLKEKCQCGREDLLIFNHCLKSYLFDKFDKFAPILPGQICNNIHDSCVDNSFCSQKSICECNDGYKMISSRCIPERLYRLPGEHCTSSTFCGESSHCVDGICKAAIKRRSLKGLKATNLICSSRRCYHAPISSTAGKIQNKDLLLVPNEEFLHDSCTSSTTRSNVTCNSNNSLKIRATCVHLLAIQWCYFGVSFFIKSLNLSLSLDIQKLNSPPGGSCLETRDCSGGSVCSEKWCVCPDPLMIVTRGTCIKPIHYMPSKLTNTVVPYMKDGNITVKKAGDQCGPLDICEKSSFCIDGECVCPAGSHKSETSGLCEPNTSCKQPEFFFEIFIPKFLAMKFVKLSEPCNNGEICVDGSICSHSKLCTCPPKLPIVYNGKCISNLHKSLPGQFCNETIECVENSSCIDRICRCVGNFVADNGKCTSSNRITVSSFGVTMQPILAEYTSNYVRSDLELSMTLNDSVQPRITGPPLRKLRIFDDNKSSDIAHAADDMYFSDGLCPKGSAPLRDSSGYLIKCNGMRPKCPSQTYCYVTSYSSETYNCCTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCR0</accession>
    <name>A0A0N4UCR0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8863</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCR0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCR0"/>
    <dbReference type="WBParaSite" id="DME_0000506401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000506401-mRNA-1"/>
        <property type="gene ID" value="DME_0000506401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="304"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000506401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56551" checksum="F2AC2F2477EBA088" modified="2015-12-09" version="1">MSTIEFMDSMQRAKNVTNHSGIMDNRKYSKGPILRKCSTPVRNCSLNFAKVPFYPPPILHTLQHNSALLDEGFFISKRKLERSSSGFDEKTNVDLTTTTTAANVDNSRELITYDSMNSVYSSGFESIAAEEIEEEGDEEDNNNEIRTICENDDIDNSYENTRKTKPPFKKSVYSFDSGTYLNESLTNSTSDILQTPASDSESNNEFLNSHEKMMKTSKNRKKYSLVKSLNKVRALSLPGIGFSKSKQHEKQKPESLPFGSGSLNRGWEFVSIDEICRRLSLDQANSKVLPLPEGASTSKILDESMIREACCDIAKILPPRAEGYPWNLIYSSDKHGYSLSTLYRKMIDWNDTMSPILLIIKDCNDNVFGGMASSALRPGEHFFGTGDSSFLFKFALNSTTKESIIKGSYKNDLRFAIIDFSCGIFHFRELKTYNWTGKNQYFVQAGKHSLLMGAGSGHYGLWLDADLNLGRSQRCDTYNNEPLAGDSEDFAIQSVEIFGFSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCU6</accession>
    <name>A0A0N4UCU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Lig_chan-Glu_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS8909</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCU6"/>
    <dbReference type="STRING" id="318479.A0A0N4UCU6"/>
    <dbReference type="WBParaSite" id="DME_0000511001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000511001-mRNA-1"/>
        <property type="gene ID" value="DME_0000511001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN58936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000511001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45382" checksum="F4896CB37B008E55" modified="2015-12-09" version="1">MIKNSYQEDEELQLEGFCIDLLAQLSHDLGFTYTINLVKDKKYGIDEYGNGSWTGMIGEILRGEADIAVAPLTVNFKRSEVVDFTKPFLSIGISILYKIPQTNKPELFSSFNPLTVETWICFLLAFRGSLFIKFFKISRRIIKSLNRYVLSTMLKGGCDFGPRAVSTRLLGGTWWVFTLIIIAAYTANLAAVLTVSKQFISIKNLDDLANQSKIAYGALEGGSTIQVVSDKANLTHMKIWKYMKSHNNIFMKSNAKGVEKVLNEDYAFLMESTSLEYEVQQNCNLTQIGGVLGSKGYSIALQKRTDCTRINSPVTQKRVALNLNNIRGLFIVLFAGLALAYLIVLIECFLRWYKRYGNNKTVFFLFLSISKLNSLTIISIFFFKIFVNFRTIILICEYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCX5</accession>
    <name>A0A0N4UCX5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CaMBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8940</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCX5"/>
    <dbReference type="STRING" id="318479.A0A0N4UCX5"/>
    <dbReference type="WBParaSite" id="DME_0000514101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000514101-mRNA-1"/>
        <property type="gene ID" value="DME_0000514101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000174">
        <property type="entry name" value="KCNN (Potassium K ChaNNel, calcium activated)-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="9">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000514101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45536" checksum="E7113FF53D9FCF48" modified="2015-12-09" version="1">EKKRKFLQGSSLSFTLKTCTLLSTIVLLALVIKFHVHEVQLFMNANSADDWRIAFTCHRILQIAIELAICSICPLPFNINFSWTTLNIDGISTNTIPLDALLSIPMFFRLYWLCRVMLLHSRLFTDASSRSIAGLNRVNFNARFIVKTLMTLCPGTMLLIFTASLWVIAGWILRLCERYHTGDPINLHAQKHQNYLNSLWLIAITFLSVGYGKFSSQRKANKRGTCTSSMVVAVIARKLELSRAEKHVHNFMLDTQLTKQLKHSAANVLRETWLLYKNRCLVDKIDAAKVRLHQRKFLVAIYALRRVKRDQRKLAENLVSLGDVAKTTSNAYELLHDVHSTQESLSLRMTAVEHQLSDICRELMALSSLLKLNGKDDSNECVSRKNTTESVRKRRNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD81</accession>
    <name>A0A0N4UD81_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9069</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UD81"/>
    <dbReference type="WBParaSite" id="DME_0000527001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000527001-mRNA-1"/>
        <property type="gene ID" value="DME_0000527001"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000527001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5086" checksum="3E90E2495BA0B121" modified="2015-12-09" version="1">MLCCAKFTLILRRHHCRCCGRVLCAYCTSHKVLIKLLCSFICPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDA4</accession>
    <name>A0A0N4UDA4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9096</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDA4"/>
    <dbReference type="STRING" id="318479.A0A0N4UDA4"/>
    <dbReference type="WBParaSite" id="DME_0000529701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000529701-mRNA-1"/>
        <property type="gene ID" value="DME_0000529701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000529701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32447" checksum="6C02D8C98E806F4E" modified="2015-12-09" version="1">MDIEVPSCSICLGSSDEQYLQYNLIVSGIILPIVGFIGLIGNFLVVIVYGSYESRKHSTNIYLAALAASDFCMICTALVLYVLEAWRHHSHQIIATMYGRSTQYTFPISTILQTTSVYFCVIAAADCFVRVVLSSKTKEAICTPRFAKITVLCITAISFAYNVPHFFELTSIICFDDRRNNSLSVQVCPTDLRTNVLYYQLYYTYMYTIFMAVGPLLIIVILNVFVVTAVFKKGASGNFYYYDTDTLSLILVVFMFIFCNSAALLVNFIEMVFAEKVFFISQFFIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDG2</accession>
    <name>A0A0N4UDG2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DM10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9172</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDG2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDG2"/>
    <dbReference type="WBParaSite" id="DME_0000537301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000537301-mRNA-1"/>
        <property type="gene ID" value="DME_0000537301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000537301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29443" checksum="32DFA165CC5A7873" modified="2015-12-09" version="1">MNSNELIFNMLSPESGIYSNEQIHRIRPMKLIYHLTDDSITLNEPVVPNSGMLQGRLITRQRVPKSDNQKGRDYLHWSDLNVGQDVQLFSKTYRLTSCDQFTKNFLEKNGIKLNKEEEIPISDNANLPANIFLLAYWLDKSNDFTGIRPKRIFKMTIYTFDDTVSLTEITGTNRNKQYYRSEDFYPGAWVNVFSRPMFIFDCVGEETRKFMQNLHGTISYTDCDKILEKGPPPDNTDNIPPTLRFIAKMVKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDT1</accession>
    <name>A0A0N4UDT1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hyccin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS612</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDT1"/>
    <dbReference type="STRING" id="318479.A0A0N4UDT1"/>
    <dbReference type="WBParaSite" id="DME_0000550601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000550601-mRNA-1"/>
        <property type="gene ID" value="DME_0000550601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000550601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45825" checksum="659E45F4B8147FFB" modified="2015-12-09" version="1">MNSEQIQNWLAELNERYKIDEKTLQDISKKHDLLNHETEKTNFLINYLHCNYTDIDLTQPIIACLLASYYKGGILRYFTLQCIPSLVHIYLLALAKRQQRSISMLNTFLVAVYNEEILAGGSGSSSPSKRIEEVRIPSIRYPSVYHDPKKLNIIPDLPQMRTAASYSEVNKYLFLHIGPYPSFIEINALNRQMILTRLLKSVNNYLCQYSRDFFCRCLCISAVAICQSGFNFHQSELCLHFFGRDLSNELSNDFSRKSRLKVSSQLLLEILNGINFAMFSGIPELAMCAVDAIHQRSVYELYADVILVTNSIRNSLLESNLQKSNMFLKIVGPIATQSALEKRKVSDAFTNASFRVKRMPEDLSPVESNYNMANKKHTFTNGEFFFHSQESKFIVVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDX5</accession>
    <name>A0A0N4UDX5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9293</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDX5"/>
    <dbReference type="STRING" id="318479.A0A0N4UDX5"/>
    <dbReference type="WBParaSite" id="DME_0000555201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000555201-mRNA-1"/>
        <property type="gene ID" value="DME_0000555201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="373"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000555201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="703" mass="80154" checksum="D6BE9E843886AF0A" modified="2016-06-08" version="2">MARFDAMISVELWLICLGFIVHIILLYSIFDIYYISPLVQNCKAYPITSGKGLASRVVIFTADGLRADTFFQNPEKSPFLHAIMKAQKACWGLSKSHVPTESRPGHVAIFAGFYEDVSAVARGWKMNPVQFDSLFNRSRRSWSWGSPDIVPIFTKGISSAASNVYSAELEDFHSKDAGILDRWVFDNVKELFKNASDILKENLSQDRVLFFLHLLALDTIGHGYKPHSEQYINNIKTVDNGIADIVEVDIAVFISALLGNAIPTNSVGKLPYTFLDASPKYIFQAAYANLMQAGFFQFRQLQPKTLSNIETMMERLIENKRYEAAAHICMKWIPVVRSGLLYFHRYDRFLSSIAISSLFFAWILLVYSAITRNILLLLCCFALAIFPQLPVVGRYPYPGLCVFTSFLNCFFMYFISSYPRFIDNATYYQIHSFLHGITVIILIFMDYVGRKQNSLLFIQLISWLLIPCTFILPLFAPKYIVGRLISWFSAISLPYSLLSVSYESFFLFIFFILLWIYIRIQFEFSNNNNYWTNMCFSTRKDFNNCGTSKVTLMTFKQALVLITLVETAFFGTGNIASLNSFNPSSLRCFISIFSPFTMAALLIFKIFLPCFAIAIVFAFIIHMKNASVANLSCLVLIISDAMAAIFFYRLVDDGSWLEIGMSISHYVLSMAISIIIFSTLHIAKYIVFLSINDIIKKKSKHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE02</accession>
    <name>A0A0N4UE02_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS627</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE02"/>
    <dbReference type="STRING" id="318479.A0A0N4UE02"/>
    <dbReference type="WBParaSite" id="DME_0000558201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000558201-mRNA-1"/>
        <property type="gene ID" value="DME_0000558201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09404">
        <property type="entry name" value="LIM1_MLP84B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000558201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25760" checksum="826BE2E9C1C86AB4" modified="2015-12-09" version="1">MPFKPIEHPKCPKCGKSVYAAEEMSAGGYKWHKFCFKCAMCNKLLDSMTCCEHQAELYCKQCHGRKYGPKGIGFGIGAGALTMDTGEQFGNKEVEMTSRIQLLPLWECGTPVLWQMSYNRINISLVAIGLCNKLLDSCTVAEHGAELFCKQCHGRKFGPKGVGFGLGAGALTMDDGSKFGNTTTEMGCTIYYNVLKMRITQGIHFLFYLHFIFNCIRPPLRRLTNSFSLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEM2</accession>
    <name>A0A0N4UEM2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microspherule protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS826</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEM2"/>
    <dbReference type="WBParaSite" id="DME_0000583201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000583201-mRNA-1"/>
        <property type="gene ID" value="DME_0000583201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000583201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="49853" checksum="2697E128FCCE2DAD" modified="2015-12-09" version="1">MKAKNSMHGIIYDLPNFLALSLNENNGSNVVMLDISTPAVIDKAESIDSSGYGSEDICEVADKEADISDNSVSPLMDKENFDSSDYGSEGSTDINERVSYVADSASLSPSTRRGENSRPDFEHVLRRLSQELRHISLLVWRQKRDGPIKIWTNTIRKILNIKEDQQYMDLDYGLASVTISENGLKIHGEDSEICCAEIGFLQDSGISGYRENGYILDGFLKEHVGLNYSAMEYKNSPEPYTLEKPPSCWLIHNGCDIGNTEMCIDIPTHNCIPPITPRSLIHHGTSLSIDESCVSVNMKNTRIAASGISGEFSCDIKSNDFMSQPLNLMKARSKCERRQPVEQVCKIRKAKLEIAAFDPDNLAAGHFRMKTPLKSNKISARQQVCATSKKNVSSLENSVAEMGRKEVLCRKKLRNTISLLPKNSSRKCSSSLVASFPVGMSGTEFLGLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEP4</accession>
    <name>A0A0N4UEP4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9384</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEP4"/>
    <dbReference type="WBParaSite" id="DME_0000586001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000586001-mRNA-1"/>
        <property type="gene ID" value="DME_0000586001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826231at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000586001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="37392" checksum="9ADED8D7B1B15525" modified="2015-12-09" version="1">MLLTNQRPQSYQPRVITSQPSPVGRANGSKHQNYFSERRHNLPYRSRSLDTEQRYIDDDFNYDDDDDWRHIKNVVQNTTKRVYNYQPYISSQATGVRPRVYLNEFYYRQNKPSPRFVDESEWYALDRSIQNYRDEMKVKPKYFSPNRTSGSSPKSDAFFKRPLRVTSFLDRGRTVMRPLTPVIRLSDKRKDNLIRRHSVDYIPSSMEYRRINQGEIVADGRNSYYPRCYDARVHTGNMDNIYYQQENASRSPRTIDAFKNERSIFNRQYGEQRFYKIHCCCFSFRWPPCVFEEVAPPQPISFNILVAIKFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES7</accession>
    <name>A0A0N4UES7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS838</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES7"/>
    <dbReference type="STRING" id="318479.A0A0N4UES7"/>
    <dbReference type="WBParaSite" id="DME_0000589901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589901-mRNA-1"/>
        <property type="gene ID" value="DME_0000589901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841389at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36879" checksum="E99B9C421E82967C" modified="2015-12-09" version="1">MLENEINWKNNHSFQQLNFGEQSIKKMGDWDDEDFEVNVEALDERRIDVFSENEEEISEKLKKLETSKPQVKEKEKAVKGFSEVVSRDLTEREQIEIQRQSDFRLAKDLFDSKQMKSKDEDDNLLYSEIDTLEEFRNFGENLGKLLIIRSKATNYHEMLISLLKVIVRNSMCLQLCSFVDASKVRQLSNFLKTMADEQTAAEKANKGKNASASKPSIKVAQKSTGKSNKKDLYDDYIADEYDDIADDFINLYQKYFKDIAQLKLGLIELLRRYESRFYVKFMYMKKSTSEGKSVFKLAIALFHNLFPSKPTNPVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEX8</accession>
    <name>A0A0N4UEX8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS897</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEX8"/>
    <dbReference type="WBParaSite" id="DME_0000595801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000595801-mRNA-1"/>
        <property type="gene ID" value="DME_0000595801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000595801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19919" checksum="F69A4A30B40B99D8" modified="2015-12-09" version="1">MNVNVTSVLAIIFFTNSYLVLGVPVFGASSEKALFKLGSFNDSSLSNKRLNRTKRYFRGFGGGCCCCCPCCCCGAPSVPPPAPPPPPTVPPPPPPPPPPPPPFTREEIFCCQPPPICIQPPPFYYKQVVTCTTENVPMPPPPPPPPPPPPAPPAPPTLGCGCCCCGMGRRKRSIHRLRSLLSAKISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFJ6</accession>
    <name>A0A0N4UFJ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABCA8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1112</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFJ6"/>
    <dbReference type="WBParaSite" id="DME_0000621501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000621501-mRNA-1"/>
        <property type="gene ID" value="DME_0000621501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF260">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="69"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000621501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39975" checksum="1835023E5845A810" modified="2015-12-09" version="1">MDSPRRPMSRDNVFVDLKYLTFGFSYLQDILDRALIKVATGEKVVTGLYAQQEPYVCKVQDTFEIDINILVLFVILSWMLPCAMLVKSIVSEKEERLKEMMRIMGLNDAIHWIAWGIQSLAFNFISVILISSLLKFGRIMPEVEFSLLLVLFILFSLACTAQCILFSTLFSRASTATASSAIIFFLLFFHYQIGRRSKSHIFALLTVALLFCVTKKLALHIAPNFIFYIIYNVESFVILLFQLLFPQTAIGYGLSIVHYAEKEFMATWVNIYYIEAPDFDISLLMILLAFIFDFVLYIVIAWYISAVFPGNFYKIFLLFNSKEHSKLVWIFFSFAIFFCLTGNEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG41</accession>
    <name>A0A0N4UG41_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysosomal acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9549</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG41"/>
    <dbReference type="STRING" id="318479.A0A0N4UG41"/>
    <dbReference type="WBParaSite" id="DME_0000643801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000643801-mRNA-1"/>
        <property type="gene ID" value="DME_0000643801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000643801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15359" checksum="B26FE74A5FE707E3" modified="2015-12-09" version="1">FWRHGDRTPIGVCKGDKNQEKRWNREWGQLTPVLFYFIMKNTIYVASTDCNRTILSAVSNLIGMFYNKNNARPDIDFPNIPEWPKNYVPVPVHTNVSRAYCVQIRLVSNSKLREFIRNFLLIFISFIEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH61</accession>
    <name>A0A0N4UH61_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleosome assembly protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1478</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH61"/>
    <dbReference type="STRING" id="318479.A0A0N4UH61"/>
    <dbReference type="WBParaSite" id="DME_0000686401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000686401-mRNA-1"/>
        <property type="gene ID" value="DME_0000686401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000686401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36657" checksum="D5DEE17E244FBF13" modified="2015-12-09" version="1">MDNNPVAKAANEAEHDDELNIQDYLRTLPKSVKSRVCALKKLQLEVINIESEFYNKIHELEMEFAPRFDSLYSKRKQIVTGEYEPSAEECDVPIIFGLPAETLNDESDPEPPEPIKGIPDFWLTLLKEVDNIGSMIQEHDEPILRHLIDICVELKSNPNEFSLFFHFKPNEYFEQTVLEKKYTIRMTPIENDPFSYDGPIVTKSLGFWKEGKNVTQTTIKKKQKKGNNAGKFISKVVKADSFFNFFDPVEINKDLGMGCELDDDEREMVEADFEIGQLFRDQVIPRAVLFYTGEIVDDGLLDQFEGEEDEDEVILNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH78</accession>
    <name>A0A0N4UH78_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1499</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH78"/>
    <dbReference type="STRING" id="318479.A0A0N4UH78"/>
    <dbReference type="WBParaSite" id="DME_0000688501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000688501-mRNA-1"/>
        <property type="gene ID" value="DME_0000688501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="222"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000688501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="678" mass="76850" checksum="3E55E2ED60C1ED83" modified="2015-12-09" version="1">MNYALYHDVFIASGVNANLSHNLFFNNTGLHCLDFRSFSSLSSEAHFIQNNWFINNVALGHGHQYLERYGFQPRNLEDEFKHRPKRQVLVEENVSFDWWTHVGRDSERYRSTIFAGTSSGIYRMNAFINPDNPYEITSARIMNFNPGSIDAKKNYWGYPGTVSVASGKIRDYKDYEYLMPVAYEPVLESNTSIIDGDCPAGWFQIGVDEFKACFLYVGAVTTYTSAIIYCQEMGAFLPYLLVNDIRQKELAKRVHVITHTFIDHTDKISSFAVNFDRHIWISSVSVPSTHCGWLSSRSGSIGTQNCNSLLPFVCEKGQIGVRPYENPPLWRSGIVFATVALIILFVSLVLLALCWYRKSRKRDEEELSRKEFIRASFRLSKMERERKERTWDSITLKKNRLFNCSKSFDYGEDLILKAHRDMVHGENKSSPTVTLRTSCSKSSILTTITDHSSKKSPTYIMNMSGPTRLVVGTGTRSSDYYSILSSVRGIDSTDHYNQIIGSSSKDMEPSGQVLKENPIFNDYKYRESDTQYSCTATCSTCATDSEKYSEVDSTLTERSFYSEASSTRSSTRSDDTIVNGHLHCRFSLSNSVAPIDRMYSSKNVDTFQASNKPVMAHMAIPAKSNVNSHMPFQPTLLPQLSYSRTSQASQSLVDLAVHHNYAQRRNSTGKALPIETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHQ2</accession>
    <name>A0A0N4UHQ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1620</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHQ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UHQ2"/>
    <dbReference type="WBParaSite" id="DME_0000709401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000709401-mRNA-1"/>
        <property type="gene ID" value="DME_0000709401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="95"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000709401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35873" checksum="8583DB42A1426726" modified="2015-12-09" version="1">RNEVTCDEDFSQKEKRKIKDFIYCFPKLQAKRARREARKKLLEKLGDAAPPKQQPRTIENTREYDMTMVSPDDEEVIYDEAHDEMSSYFSRITKPKVLITTSVHAKVKSFKFCCELQKCIPDAEIFTRKNIPLKKVVQQAKEKEYSDLIVVHEDRKVPNGIVLCHLPNGPTAYFKINSLKFRKDIKGVGESTGHHPELILNNFNTRLGHTIARMFACLFPHNPMFVGRRVVTFHNQRDYIFFRHHRYEFKKEGEKASLHELGPRFTLRLKWLQKGTFDTRYGEYEWVLKRHEMETSRRRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHQ6</accession>
    <name>A0A0N4UHQ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1624</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHQ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHQ6"/>
    <dbReference type="WBParaSite" id="DME_0000709801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000709801-mRNA-1"/>
        <property type="gene ID" value="DME_0000709801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000709801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19700" checksum="019DE56A69113602" modified="2015-12-09" version="1">MELHQRHFEKAGSRSEEFASGLVPLCSNNSSTQFLPLNEITTQQFTLVDCPINPPRKILNGDPNRSSDLRDITSTSGVNIQSSELRTGVESFNYVKPTKYEAEICSSCAEYIVDRNLLTVNSQYWHVECLRCSQCSIRLDQYPSCFFKDNVIYCKQCYNRRYANANANKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI09</accession>
    <name>A0A0N4UI09_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1691</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI09"/>
    <dbReference type="STRING" id="318479.A0A0N4UI09"/>
    <dbReference type="WBParaSite" id="DME_0000722001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000722001-mRNA-1"/>
        <property type="gene ID" value="DME_0000722001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000722001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13953" checksum="D2218A5724ED3C24" modified="2015-12-09" version="1">MECTANERRRIESAGGFIEFKGVERVQGILSVTSQPDKYHAVPSQSSDEYEYDKAFGDTDLKRLCVLTAHPDIVRVDLRQITLRFILVASDGFWDVLSNQKAINLAKKFLAKEPQAHWHKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIT0</accession>
    <name>A0A0N4UIT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1794</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIT0"/>
    <dbReference type="WBParaSite" id="DME_0000752701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000752701-mRNA-1"/>
        <property type="gene ID" value="DME_0000752701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="428"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000752701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="680" mass="76001" checksum="6B78A2571124A80B" modified="2015-12-09" version="1">MTVGDLITEHEYQFRVIAHNAIGFSEPSDPSPPIVIGVPINGDAKFVGAQYGSFPLLQDEIIRESPPLPDRDDSPPPINRTYMKGKDGLHWRDPTLKEVIEYLDSPNKIEQLNASGYLQHLTYNDNAIKEETRELHGIPKLVRLLSSDAPEIQKNACGCLKNLSFGKENDENKRAINAAGGIEALSALLRQAADALVREEVTAVLWNLSSSDDLKMTILEHSTDAIVQRIIVPASNRVIQNDMNSGRSYNINIFRNASGVLRNISAASPLARKTLRNCPQLIDGLFYFLTRAVSKSQVDSRTVENVVCILRNLSYRIQEVKEPNYKPLKIELNGSNRERSRSAPSGSPRIKKKEPKKKKGKHEATVSEVPPTGILLLWQPELVRLYLKLLQEASNSETLEASAGAIQNLAACHFEPSVQVRAVVRTEKGLPILVELLRLNDDKVVCAVTTALRNLSLDPRNRELIGKYAMKDLVAKLPRVDQQSRNHLISDSTIGAVLGILFEMVKYSADFTRSIHECGGTERLRLLARSHPLYSARICKYASQVLYMMWQHKDLHDGFKRSGLKETDFFSGPAYKARDTTTLARPISSQGAERPVNLRSEIFDDSASACDTAKHDEHIRLGYSESPRSVNQDRTFLLDPSNRYQSQSPVSCQQPYEPLYASVHKYGNTRRQSAGGDSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIZ3</accession>
    <name>A0A0N4UIZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1864</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000035">
        <property type="protein sequence ID" value="VDN51891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIZ3"/>
    <dbReference type="WBParaSite" id="DME_0000759701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000759701-mRNA-1"/>
        <property type="gene ID" value="DME_0000759701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF23">
        <property type="entry name" value="LD06925P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="190"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000759701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58894" checksum="9CBB68D56C1AE5A7" modified="2015-12-09" version="1">ASPSQQKQQQQQQQQQFCTLSTSSSSTEATRQSRTESEIKAAKIREALEKMREADIKKLYVKFFLDDGASTISLLVDERWTVAEILRHIASKQKIPLTEQHAIVEEYPELYITRIYEDHEYLVENIMMWVLNSPNKLYFTRRPDKYVFIERPAEFLVSERNIDVLSQGPPSPDTKRQIVKDFFENDHVEPPEMEGWLMLKSDGRKSWKKYFFILRSSGLYYSSKGKSRNSKDLQCLMNMQTNQVYVCSEWKRKYKAPTNFGFAIKHPKIQVKASKYIKYVCANDAITFHKWMAALRIAKNGRQLYDNYLAAKKFMECITTQPVKVDIPQINASATMNYDRFSTISAQRNGHQDPPSFLNLNREIIPERVNKISPCANSTSDACCSNHSSIVFDQCDELLTGTIKRAPCDFLSQCRRQSSHYDRYSSSGGTGSPTVQSIGDAADSDSDEEQFPPPPPMATTPETNLVQSTQKIKKVPPPPPPKRADTTRLHTANIDALHNELEIAMARSKGFCDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJG0</accession>
    <name>A0A0N4UJG0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">[Histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10165</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJG0"/>
    <dbReference type="STRING" id="318479.A0A0N4UJG0"/>
    <dbReference type="WBParaSite" id="DME_0000779501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000779501-mRNA-1"/>
        <property type="gene ID" value="DME_0000779501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15493">
        <property type="entry name" value="PHD_JMJD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="9">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="156"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000779501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="859" mass="99198" checksum="A60FFCEBC9C922F0" modified="2015-12-09" version="1">MEEASTSDYWKGHPRFTSTGTIDVPVFYPTIHEMRDFPTFIDKIEQMHHAHLICGIVKIVPPPEYHARKSNDYSDVDNYIIEQPVKEKIEGSGGIYTKTNRLFRKSISVRDFRVLCDKMRLPKEGLSPEEVEKYYWKTILQGEPVYGADTPGSICDPDLKEFNMNHLNTVLDLLDNFEIKIKGVNTVYLYFGMWKTTFPWHTEDMDLYSINYLHYGEPKFWYAIATESNSRFERLAAQTFPSAAKNCKSFLRHKTFMISPHVLKRYNIKFGTMVQYPNEFIITFPRGYHMGFNMGYNCAESTNFASDRWVDFGKNALVCTCRADNVEIDMRPSMKQFRPDEYNKKMVRKLCLGKNALVCTCRTDSVEIDMRPFMKQFRPDEYDGWFKYWYGERIVKEKKKVSASKRQPIHNDSAVEKKRRRINQMSKGTRGPYIEISQDSGSDSNEDENTRFMNSKSMADLISNDQWKKKVRLLWSNLPIDFNAEREFNNCRASESPHCSVCQYFVPKPLLIKRDRIPASSVRLIRRAWYAKVDPDQCDIDDNAIEDRLLRCSNCYVVVHFGCYPVGNVPADINEWKCARCCRRDDLMIRFASCHLCELRGGALIPAMNSSGDFVHVICALLNRRTIFVDPIRLDLAYTRPFKKLRASVLFENRPSAEYLNASDLNSDLGKFECEYCLNSREGLLKCVLCDDVLFHATCGRLAGVSYEFRNWPDLTVAVCPDHNEVVDNAPPLIVGDKVRVAVDGSRKMVKGMVLNIEYHDCCTISFMDRNWSDDVIPSDIVECECDRIGCGGFHVPGAKIRLKWDDGLIYDGVFRNRYKRATYIIQLAANFSKLPKIIKVGRDAIFARGEKPVNLDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJM1</accession>
    <name>A0A0N4UJM1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">S-adenosylmethionine mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10214</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJM1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJM1"/>
    <dbReference type="WBParaSite" id="DME_0000786501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000786501-mRNA-1"/>
        <property type="gene ID" value="DME_0000786501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="171"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000786501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28942" checksum="08C8F116258CF430" modified="2016-06-08" version="2">MEETILRGLISGAFAGLSVDLTLYPIDTIKTRLQSSQGFNASGGFRNIYRGMSSVVIGSAPSSALFFSTYSSVKHIVKSESPLASSFAAIVAETVACIVRVPTELVKQRAQAENDRPIIAICRDIYKNEGLCGFYRGYSSTVGREIPFSFIEYPLWELLKQQISSLFGIPYSPFISATCGSAAGSVAAAITTPLDVTKTRIMLNEEKNPPGVILTLRNIAREGGVKLLYSGVLPRTLWMGIGGFIYFGAYELMMKITFWLYPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJW3</accession>
    <name>A0A0N4UJW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2099</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJW3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJW3"/>
    <dbReference type="WBParaSite" id="DME_0000797401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000797401-mRNA-1"/>
        <property type="gene ID" value="DME_0000797401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8114442at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000797401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26438" checksum="36CEE329C6AE0147" modified="2015-12-09" version="1">MIARNMDEFLNGGEIVDDPFLPIVDGKLCVCCEKGNAEWMEGTTYDFDDYLMNFSISHRNDWIDLISSNNGNNDGIEVDAQDFFCKTFILRPENLKFEIYLNDKDSLLPIDLDGPRKRYQRFRAKRFICDHCDRSFTLKQNIQYHIVNYHLKNQNIRLKRGRRYVCRVCQKMFKSGDLARKHHERKHVQLPAISIHRCSTWSDTLHAASSSPDAHDASNPVVHAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKJ6</accession>
    <name>A0A0N4UKJ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RPN2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10327</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001211">
        <property type="protein sequence ID" value="VDN60354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UKJ6"/>
    <dbReference type="WBParaSite" id="DME_0000826601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000826601-mRNA-1"/>
        <property type="gene ID" value="DME_0000826601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000826601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35688" checksum="861757E3100D015A" modified="2015-12-09" version="1">MIIVEAVALFEQLIVAKENFVRQGAVLALSFILIQQTEASSSKVGEFRRVLTKMITEKGEDSITKLGAILAQGIIDAGGRNVTISLHNRNGHSDMQSVVGMFVFLQYWYWHSFAHFASLAFKPTCLIGLNSNLEMPKTEFRSNAKPSTFAYPPPLEEKKKEENERIEAAVLSVTNKKKISASEKILEKKEKRDENKEKQEEEKMEIDLNDSLIDNKSLSEGKNASTMKEPEPLMHNLQNPARVVRLQLKTLQMPESSRYKPLKALSQGGIIMLKDKKAGEEQEEIVALVAAGGTRASDVKDAGTEEAQPHAPFEINIASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL16</accession>
    <name>A0A0N4UL16_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport protein Sec61 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2440</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000061">
        <property type="protein sequence ID" value="VDN52467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL16"/>
    <dbReference type="STRING" id="318479.A0A0N4UL16"/>
    <dbReference type="WBParaSite" id="DME_0000846501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000846501-mRNA-1"/>
        <property type="gene ID" value="DME_0000846501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000846501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8245" checksum="7057860D915B4439" modified="2015-12-09" version="1">MSDTGRSGRDTAGLRQRRGGRTARSGVNSGGLWRFYTEDATGIKIGPVPVLVMSLVFIASVFVLHIWGKYTRSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL98</accession>
    <name>A0A0N4UL98_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10409</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL98"/>
    <dbReference type="WBParaSite" id="DME_0000856201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000856201-mRNA-1"/>
        <property type="gene ID" value="DME_0000856201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855340at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229921" evidence="2">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000856201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="21480" checksum="0AF13C6D8F623747" modified="2015-12-09" version="1">MFGLLIVCYLLHVVKSGDLSVNIVECRNAGPMFRPKDETLCVAVFNPLGSDAANNANPAMTYKVNANCENATLKANALALCPSSCALCFSTAGADCTPFTISQDLCTNSQTAAAALANCPKACGLCNRPGAGGRCPNAVTNCATLLPIAWRHAGSQLVYVSSTTGGASSSCSDGRANCAQMASFCNVPPYSEVMKEQCRRTCNICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULI0</accession>
    <name>A0A0N4ULI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2570</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULI0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULI0"/>
    <dbReference type="WBParaSite" id="DME_0000865501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000865501-mRNA-1"/>
        <property type="gene ID" value="DME_0000865501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000865501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10271" checksum="AB25CD57807281F8" modified="2015-12-09" version="1">MSQSREYYFVIVGHNDQPIFEIEFPVCDAKRKREYDARHLNQFIAHASLDIVDEQILTNPQMYLKVSLFLFIFHCKNWIVLFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULR7</accession>
    <name>A0A0N4ULR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2645</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULR7"/>
    <dbReference type="STRING" id="318479.A0A0N4ULR7"/>
    <dbReference type="WBParaSite" id="DME_0000875401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000875401-mRNA-1"/>
        <property type="gene ID" value="DME_0000875401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000875401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36517" checksum="F62C6882893D78F8" modified="2015-12-09" version="1">MMMMENEMKSSPSLETYSLYMQTGFSMQPTSTSSVPPEEIDPDSPGSPSSREKKADDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGLEWKQLNEADKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKNMPKKNGLTMPTAFLDPIKQSIYNPVPTWQQPITSVAAPPYFDSYNLYARPGYENMIGMQYSLGATASPSQYAQSPASLAVAAAQYQQVQQQQQQHQQQQQQHYGSSSVILPIKPEVENPASTGSPDTPSISDAPSLTQFRAFYEPPKEPMNMYLPQNQDPRLQYPSLNGVDSHMNIPLQHMPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULV1</accession>
    <name>A0A0N4ULV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10481</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULV1"/>
    <dbReference type="STRING" id="318479.A0A0N4ULV1"/>
    <dbReference type="WBParaSite" id="DME_0000879301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000879301-mRNA-1"/>
        <property type="gene ID" value="DME_0000879301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF11">
        <property type="entry name" value="CUTICLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000879301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27397" checksum="BEEFEE1034EBF008" modified="2015-12-09" version="1">MKFQVRFDTRNVFNGLVFVEDHLSDPECRSSTVKGLNKNGCNASLKLGFRGCGIERRRSNDPKGMFITTSLIVAFHPEFLTKIDRVYVVQCFYMEMEKILQKDIQIKMPSPPLQTGQVPMPICRYEVLDGSPSGPPIFYATIGQMVYHKWTCEAEIENQFCMIVHSCYVDDGNGDRVQLIDRNGCAQDKYLLQNLEYLSDLMAGKEAHVYKYADRQSMFFDCQITLTIKEQQQIACPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMN9</accession>
    <name>A0A0N4UMN9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2861</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000085">
        <property type="protein sequence ID" value="VDN52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMN9"/>
    <dbReference type="STRING" id="318479.A0A0N4UMN9"/>
    <dbReference type="WBParaSite" id="DME_0000912401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000912401-mRNA-1"/>
        <property type="gene ID" value="DME_0000912401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="243"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000912401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41045" checksum="A6A04C9CDDCA78CA" modified="2015-12-09" version="1">LFLKIHSKFRFRESSAYKEKQVPPSVTTATVTDLEPFQLYEISVLAINAIGRGIATMPKEVQTDEFAPTTPPQRVQARALNRNSILVRWDPPEKPNGQITLEVKSDELITTLHDLEIEQTYYISVQAKNSKGLSPASKLVTVITKHGIPGQPMSLVAKPLDSRRIHLSWEKPIHSYNIIGYSVWFNNSVGAARQLTLTNPVNKHIIDGLEPNTIYSFRVAAQSSRGLGAYCEDVYAKTYPNVPSGSPKISSFETISSRSIMIQWSTPIIDIQDGDLINYKIKWHPIPDSDSAVNTTADSSDNNELYDDSIENNKDHEWNELVRDATLGNSVVLNDLKPFTSYKIFVAAGSKGGFGPLSQPLYIKTPEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMP7</accession>
    <name>A0A0N4UMP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2870</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMP7"/>
    <dbReference type="STRING" id="318479.A0A0N4UMP7"/>
    <dbReference type="WBParaSite" id="DME_0000913301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000913301-mRNA-1"/>
        <property type="gene ID" value="DME_0000913301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="69"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000913301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45457" checksum="F246CF3E2274B879" modified="2015-12-09" version="1">MPSLSAPVTPSEISGKLDFESNISPLTRALDRTLQVKCMRMQSFIDNHRHELHLHVNTLRQFASSSGGLVLDEIRSVVWPILASSLIADFASDHGSSSESGFESAVSQFSDEEDTPSSSKTVIFTPSLNDLMRHGEWNQVELDVKRTLSRFPPNISDSDRVHLQKELTPLIIRILWTCPHFHYYQGFHDVCLTLLLVLGVQAAESVGVNLAKNGIFNEYLLRTLEDTVLRDLDLMYIILWKVDSEIERIMRSVQLGSLFALSWPLTWFSHAFHHYRQVVLCFDLFLASHPLMPIYFSSAVVLWRSSSILSSSYEMPILHHLLNIMPDEVPVRALAADAQDLFRMLPPSLLRGRLSKDYCKLLKETHMRKPSLPTTSLKAWLVAGTATAAVYMLSRYLFITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMS4</accession>
    <name>A0A0N4UMS4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2902</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000088">
        <property type="protein sequence ID" value="VDN52929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMS4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMS4"/>
    <dbReference type="WBParaSite" id="DME_0000916501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000916501-mRNA-1"/>
        <property type="gene ID" value="DME_0000916501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000916501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32836" checksum="044FA5939A9432E9" modified="2015-12-09" version="1">MLDPKWITTEECMTKTKRLNEIFILPSFHGRVFEHLLSIKSRIYGAIVARTCLKKMERLPKSVHPILSFTLKGAMICFTDISHAVRLCVNFYLVLKHLVKQMALVKYMGGSVSRNFTRKVTHLVAHSHATNSKKYSVAAHNKIPLMTAKWIEDAWKTACSRNNISFLDAKIIKKYRLRLFAGCKNFLKLVPFKKMTCSGIDGEERKKIARIIERHGGIYAGDMERSSSTHLLICKASGEKYNVARKWGWEVIKIVHKRWLGHCLRRKTFSFQHLVEYQWQINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMW4</accession>
    <name>A0A0N4UMW4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2952</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000091">
        <property type="protein sequence ID" value="VDN52979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMW4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMW4"/>
    <dbReference type="WBParaSite" id="DME_0000921501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000921501-mRNA-1"/>
        <property type="gene ID" value="DME_0000921501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850392at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000921501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27693" checksum="D3438AE9B0879BF1" modified="2015-12-09" version="1">MRCDCRDWYGRCKLKGEMWIDDEIWNYMCQRGYGEDANFIGCLTHEKTTEKRLILMNTNVTIDGFWFSCESDEKRIKYEEEPRCMINETKFHVGDEFRDGFFNWICLDTGRWVTGCYYQNESKHWIKLKIGEIAYNGLVMHVCDRYDDYPGRIQYYAEVRKDIAQKNPTNKGINANLPEPIDNRLKKPPIRWLHENAADFIFNDNPFRLKIRYLPSSRRSWTTVLPSQHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMW8</accession>
    <name>A0A0N4UMW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2958</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000092">
        <property type="protein sequence ID" value="VDN52985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMW8"/>
    <dbReference type="WBParaSite" id="DME_0000922101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000922101-mRNA-1"/>
        <property type="gene ID" value="DME_0000922101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000922101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16216" checksum="F0C595AFD854C383" modified="2015-12-09" version="1">MAPRKGKIKEEQPVVTLGPQIKEGEKVFGVAHIFASFNDTFVHVTDLSGRETIVRVTGGMKVKADRDEASPYAAMLAAQDVAERCKALSINALHIKLRATGGTKTKTPGPGAQSALRALARSGIKIGRIEDVTPIPTDCTKRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMZ5</accession>
    <name>A0A0N4UMZ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF2214 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2992</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000095">
        <property type="protein sequence ID" value="VDN53019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMZ5"/>
    <dbReference type="WBParaSite" id="DME_0000925501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000925501-mRNA-1"/>
        <property type="gene ID" value="DME_0000925501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288">
        <property type="entry name" value="PROTEIN CBG16535-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000925501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13507" checksum="11F7DA2CA3B4B426" modified="2015-12-09" version="1">MHRILGTNECVANYLDGGFMRGLWCLSHAGALLLLPIAIFILTKPSWLLWPALLMQSSYALGLAILSMAIAPKLMDAFSGKVNVGLIYSFGIFVTGFILNWFFTLVLWHFYWYIESKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN30</accession>
    <name>A0A0N4UN30_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3015</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000096">
        <property type="protein sequence ID" value="VDN53042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN30"/>
    <dbReference type="STRING" id="318479.A0A0N4UN30"/>
    <dbReference type="WBParaSite" id="DME_0000929301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000929301-mRNA-1"/>
        <property type="gene ID" value="DME_0000929301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000929301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12771" checksum="99D7E622CECC5EB1" modified="2015-12-09" version="1">MAVIKVVVANGYDELKKIVAESKIRTVIYFSASEDGYGKSWCPDCVSASKPLFSFSSWKDKENPFRKDEHFKLTCIPTLMEYGDKVSVRLRSIYSNIDFFIFLQNGDEKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP00</accession>
    <name>A0A0N4UP00_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Spectrin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS10718</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001239">
        <property type="protein sequence ID" value="VDN60745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP00"/>
    <dbReference type="STRING" id="318479.A0A0N4UP00"/>
    <dbReference type="WBParaSite" id="DME_0000966601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000966601-mRNA-1"/>
        <property type="gene ID" value="DME_0000966601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018565at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11808">
        <property type="entry name" value="SH3_Alpha_Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000154">
        <property type="entry name" value="Alpha spectrin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000258">
        <property type="entry name" value="Spectrin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000032">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000035">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000043">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000078">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035825">
        <property type="entry name" value="Alpha_Spectrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="1020"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="2310"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="2353"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="344"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1263"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1685"/>
            <end position="1755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN60745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000966601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2460" mass="285518" checksum="1A35BA4CB8F2A123" modified="2015-12-09" version="1">MIESSTAPPEPVLEVPPPQEIKILETADDIQLLSDVGGIGQESSDIISPSEILVSLIVIDFDYQDFLFFKNRRSEVLGHYAQFKVYAKTKRDRLEDARQFQYFKRDADELEIWILEKLQTASEESFRDPTNLQAKIQKHEAFEAEVHAHSNAIAQLDKTGSDMIQHDHFASEIIRKRLDELHALWDQLFFKLKDKGIKLQQALKLLQFIRQCDDVLYWIRDKEAFVTAEDFGMDLEHVEVLQRKFEEFLKELGNHHYRITEVNQAADKLIEEGHTEQNTIYNKREEVNEAWHRLNTLAATRREGLFGAHQVQRFNRDIDETLAWIGEKDATLSTDDYGRDLNNVQALQRKHEGTERDLAALDAKMNSLAIEADRLAQVHPDRADAISAKMNEAKDQWAALKRKAQARKDGLDRSYNLHRFLADYRDLSSWINDMKAVISADELAKDVAGAEALLESHQEHKGEIDAREDSFNQTAEAGQRLLDEDSEQSDDVREKLGHLAKKKASLLSLWEERRILYEQCMDLQLFYRDTEQAETWMTKQEAFLANDDLGDSLDSVESLLKKHEDFEKSLAAQEEKINALDEFATKLIQGQHYAADDVSRRRALLLERRRHLMQRAAERRRQLENSYRLQQFDRDCDELLSWIMEKLKTAKDDSYLDPTNIRGKLQKHLNYEQELKANKNRLDEINTTGQSLIEKNHYAADHIRKRLGEVDGMWDELVDATAKKGAKLKEAGDQQQFNRNVEDVELWLSELEGQVASEDFGKDLISVQNLQKKLGLLESDYNAHQDRIDAIKQQAKTFYDSGHFDAPMILRKQETLHSRYENLLDPLNKRKNKLAESLKGNQLFRDIDDELAWIREKEQVAASTNRGRDLIGVQNLIKKQQALIAEIANHEPQIDAVSASAEQMISQGHFLAPDIRDKLAQLRDNWRNLKAKAEKRRQELDDSLQAHQYLADANEAESSMREKEPVVGSTDYGKDEDSAESLLKKHRALMSDLEAFKSTIDELRKQASQCRYQEQPGGQLGRECVMALYDYTEKSPREVSIKKGDILTLLNSSNKDWWKVEVNDRQGFVPAAYVKKVEPGAAQRQSQQVSSIGVKQNEIEDQYQKLLILGETRRRKLEEACKGYQLLREANDLADWIRSREAVAAQQEIGSDLEQVEILQKKFDDFKGDLKANEIRLQEMNQIATALTSVGQTETAVRIRQQIDDLNARWRALEEQTEQREQQLGSAHEVQRFHRDIDETKDWILEKDDALDSEDFGRDLRSVQALQRKHEGVERDLAALGDKIKTLDEKANRLRQTHPEAAEQIYDLQRELNEQWNRLTTKANNRKERLLDSYDYQRFLSDFRDLMQWIAAMNQLVSSDELANDVTGAEALLERHQEYRTEIDSRAATFQAFEQFGNQLLNSHHYASDNIKQRLNDVNEARRKLEDAWIHRRHVLDQCLELQLFNRDCEQADTWMSAREAFLNQEDTGDNVESLIKKHEDFDKAIASQQEKISALRTFANQLINSDHYGKDAVADKRDQILQRWDRLKSALIEKRSKLGESQTLQQFSRDADEIENWIAEKFQVAQEENYRDPTHIQQKHQKQQAFEAELAANADRIATLISAGQNLIDGSKCAGSEDAVSQRLKALNDQWEMLVKTTSEKSYRLKEANRQKSFMAAVKDLEFWLGEIEGLLASEDYGKDLASIENLLKKHQLLEADIAAHADRVAEMNTQADNLLENEQFDRPEINNRRKIINDRYENVKKMANLRRDNLNKAITVHQFLRDIDDEESWIKEKKLLVSSDDYGRDLTGVQNLRKKHRRLDNELASHEPQVFLVREKGLELANMSNVCASEIKDRMAALEKSWDEIKNITGKRHQKLNESEDFQIFIGKVEEEEAWMNEKQQILSSDNFGENMAGVQGLLKKHDAFEADLVLHNQRVAQLIKDGQKLIDAGNHHSPTIKARCDQLRNRLDEITELARRRLQKLRDSSAYLQFIWKCDVVESWIAEKEQQVRSDDFGRDLSSVQILLTKQEAFDAGLNAFEHEGIQRISELKDQLVNAQHAQTPAIEKRYGNVIMRWQQLLGNSNARRQKLLKMQEQYKQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEISALREAHAEFHKSLSVAEEDFKQLQHLDKQIKSFNVGPNPYTWFTMDALEETWRNLQKIIKERELELQKEHRRQEDNDKLRRDFARQANAFHHWLTETRAAMMETSGTLEEQLELLKRKVAIDVKNNRAQLKKIEDLGALLEEYLILDNRYTEHSTVGLAQAWDQLDQLAMRMQHNLEQQIQARNQSGVTEEALREFSMMFKHFDKEKCGRLDHQQFKSCLRALGYDLPMVDEGQPEPEFQRILDIVDPNRDGYVTLQEYMAFMISKETENIQSSEEIESAFRALSKEFRPYVTAEELYANLTPEQAEYCIKRMKPYTDAISGRSVPGALDYEQFVHTLFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP24</accession>
    <name>A0A0N4UP24_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10737</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001241">
        <property type="protein sequence ID" value="VDN60764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP24"/>
    <dbReference type="STRING" id="318479.A0A0N4UP24"/>
    <dbReference type="WBParaSite" id="DME_0000969201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000969201-mRNA-1"/>
        <property type="gene ID" value="DME_0000969201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000044">
        <property type="entry name" value="TBC Kinase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="464"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000969201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="817" mass="93627" checksum="E471AC21E9ECAB3A" modified="2016-06-08" version="2">MQHWYRNEDNVVRLLGRAEFGAIVLIGKDVRHSTSNNGGLPTVSSSVRMLGRFPFIASLSHPNLVSYTEIIRSTTLEDAIILISEHYSSSIYTEIRAKNCIETEKIISISNDILSALDYLHSQLIVVGYFTADSLQLTSEKMTRLAQYGIYYISGGGEDIESFVASPWYLSPERLLLLMHGSKTAMRQGDIWAFGIILLEMSCTCLLSDLWNVEDFLNMIMSFVKSGFKSLLRPLLQEIHEKCPSIHINFDPNICSLVELMLSVESSARPSAKWLLTEFKKLKIDSSSSFDINIYSKYGIYSNGFGLSMNIDQLKARINREGEGYLQTQPLKEAFFLWKLSGSTVENILLNHGIIKANSPITTLPAIVTGDCFMFGNSSRRYDSIFDIFILPSINLRNRFSSISKDRFILNFDCTGITVDENKLSLFVKEKDIEYQARRMFVFRRLLAASTYKRQRLLQECKRDIAPFHRAFVWVSLLNISYDVNRQFEFVDTFTEHSADRQLMVDIPRCHQYDELMASPAAHRKLKRLLKFWLLSHKNYVYWQGLDSLTAPFLVLHFERLPFAYACLESFISLYLNDFFLKDNSSVIQEYLAVFNHIMAFVDAKLYTHLSKMDFSPELFAIPWFLTCFAHVLPLHKLFHVWDVVLLADSSFPLFIGLAVMEQLRPRLISSNFNDAILLFSDLPDLNMEHILLYSQSLYDSVPASCTYRKHSSKHVREVHSMKQLSVNDLKEYSCPRLSVVDLIRLINTSSVLIVDVRMANEFSRCSISGSINFPPIGDDDYLDAIRSALINAQILNHIIVFIDSQPGFRAKKVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP99</accession>
    <name>A0A0N4UP99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3388</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000128">
        <property type="protein sequence ID" value="VDN53415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP99"/>
    <dbReference type="STRING" id="318479.A0A0N4UP99"/>
    <dbReference type="WBParaSite" id="DME_0000977201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000977201-mRNA-1"/>
        <property type="gene ID" value="DME_0000977201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920520at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000977201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="34690" checksum="0B808A79EE477995" modified="2015-12-09" version="1">MDLDTRIKAYRFVAYSAVTFSVVSVLSVCVTLPMVYNHVHHIRRQMHNEVTYCKGSAKDIWSEVHQLKNVPPRNNRTARQAGYGEDAGVTGGITSRGGCDGCCLPGPAGPQGAPGKPGRPGKPGAPGRPGNPGRSSQQPCEQPSPPPCRPCPAGPPGPPGPAGPMGDPGAPGRPGSDGQSGPPGPPGPKGAPGAPGPAGPVGPVGDPGANAAGGPVSPGPPGPPGDQGPPGPPGPPGQPGSDGVPGPAGPKGPPGPDGAPGPDGQPGRPGAPGNRGTSGERGICPKYCAIDGGVFFEDGTRHLNKYYKLLNQSKINFYPSLFLIIKIIHDFIGIIGNSSLGGPEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPN1</accession>
    <name>A0A0N4UPN1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3473</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000137">
        <property type="protein sequence ID" value="VDN53500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPN1"/>
    <dbReference type="STRING" id="318479.A0A0N4UPN1"/>
    <dbReference type="WBParaSite" id="DME_0000992501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000992501-mRNA-1"/>
        <property type="gene ID" value="DME_0000992501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF116">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000992501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="35306" checksum="35F5995CF5F3B061" modified="2015-12-09" version="1">MKCKTAIDQGNRLLITIIISEPRNPESSPLPKCRHIDPYDRIDIWAWNDANSSSCDPITAFSEITDAREKERYKWGYSKFAYNLLVSDKIGPRRYLPPMYHELCSNIPYDGLTMNASIIIIYHNEALSVLIRMLNSIFDRTPSYLLKEVILFDDMSDEDAIVVEKVLQYANIDEWPWEKLIVKRSEKRLGLIRSKMWLCGGSVVVAPCSRVGHVFRNRRPYKTRDDIDTHLFNCLRTVKVWFDDYEKYFYHEHPKAKTMDFGDLTERLNLKKSLNCKPFEWFLREVYPELIPQIKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPZ0</accession>
    <name>A0A0N4UPZ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2853 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10831</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001253">
        <property type="protein sequence ID" value="VDN60858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPZ0"/>
    <dbReference type="WBParaSite" id="DME_0001005201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001005201-mRNA-1"/>
        <property type="gene ID" value="DME_0001005201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001005201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9030" checksum="C31B6774138A03CA" modified="2015-12-09" version="1">MHFTDPNIDGTSGKADKAVFTYLKMSVKMFIPLWDTRTSKEQCQDEMAKCVQDISENPQEIRQTVKNMEETSYCISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQW1</accession>
    <name>A0A0N4UQW1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peripheral plasma membrane protein CASK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3876</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000206">
        <property type="protein sequence ID" value="VDN53903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQW1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQW1"/>
    <dbReference type="WBParaSite" id="DME_0001042101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001042101-mRNA-1"/>
        <property type="gene ID" value="DME_0001042101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12035">
        <property type="entry name" value="SH3_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000016">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="128"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="215"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="354"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001042101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61214" checksum="4141C896CF8684C4" modified="2015-12-09" version="1">MLFSICSKIDVLLQPSAEANELRSLLSSFQIQAVLQAHDVIVHEIYEGSGRELNAQASSSSDISHQQLPNTSSNVQISQLPFSYLNGGVLPFQSAVASSSHEMPSSIIPPLFDDDDDLMMDVVSRVRLVQFQKDTEEPMGITLKVTEDGHCLVARIMHGGMIHRQATLHVGDEIREINGVSVNNQSVEALQRMLRDARGAVTFKIVPSYRSAPPACEIFVRAQFDYDPAQDDLIPCPQAGVPFKTGDILQVISKDDHNWWQARFVCTFPALGSSHSGNQTPGASVAGLIPSPELQEWRTACLAMERAKDNTHCMWFNKKKKYYTTKYLQKHSALFDQLDLVTYEEVIRLATYRRKTLVLLGAHGVGRRHIKNTLIHRHPQRFAYPIPHTTRQPRKDELEGKHYYFVSSDCMLADIQANEYLEYGTHEECMYGTKLETIRNIHRTGKMAILDVEPQALKVLRTAEYSPFVVFIAAPNLQGLQDPDGSLERLLKESEILRQAFGHLFDYMIINNDIDETIRQLELIVEKLHACPQWVPVSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR46</accession>
    <name>A0A0N4UR46_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3957</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000230">
        <property type="protein sequence ID" value="VDN53984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR46"/>
    <dbReference type="WBParaSite" id="DME_0001051701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001051701-mRNA-1"/>
        <property type="gene ID" value="DME_0001051701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001051701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23471" checksum="0E098B9B1C0B6A80" modified="2015-12-09" version="1">MKLECSGSLDFLFYPFIGYICIVHYSSLSAEDLSSFGTGYNGGPFKIVKQRNLKVGDILQFGRNYLIINELRPSTSNADEVFEDDVAEAPSNSYSVQNIFEKKKFNIRSVSNKNEKAKLFLLSSDDEDDDIIDQSSSTIFAFDTLRQSLKSQYYRKVSDNIDHTKWISSNYPTGVVSESCVVKDDTVHNQADDRFVVKSVFKFKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR51</accession>
    <name>A0A0N4UR51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3959</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000231">
        <property type="protein sequence ID" value="VDN53986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR51"/>
    <dbReference type="STRING" id="318479.A0A0N4UR51"/>
    <dbReference type="WBParaSite" id="DME_0001052201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001052201-mRNA-1"/>
        <property type="gene ID" value="DME_0001052201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001052201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14995" checksum="955787FD23F66BF1" modified="2015-12-09" version="1">MSDRMVLAQLWVFFYMPNISGKVFIPQNNFPISTRQFEDGMIFTNFLPQISLEDSWEMRFSCCSSGPNGQACTVSESHVTNTAFWSDLSGFIEIPAPSDPSDSRNGKIYVLDSEMVYTRRGLSIARVTLVNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR67</accession>
    <name>A0A0N4UR67_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3973</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000235">
        <property type="protein sequence ID" value="VDN54000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR67"/>
    <dbReference type="WBParaSite" id="DME_0001053901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001053901-mRNA-1"/>
        <property type="gene ID" value="DME_0001053901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866215at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001053901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11048" checksum="39B9782078FF9BD0" modified="2015-12-09" version="1">MTAILIQARATSVENCKSEKLRELVLETIGLFPHQYSYQARYMKQQAELRFGNWWSAVIIGEKGGYGMSAVYDQYTNTSCELRIFDTYYWIGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM4</accession>
    <name>A0A0N4URM4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4115</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000304">
        <property type="protein sequence ID" value="VDN54142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM4"/>
    <dbReference type="STRING" id="318479.A0A0N4URM4"/>
    <dbReference type="WBParaSite" id="DME_0001070601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001070601-mRNA-1"/>
        <property type="gene ID" value="DME_0001070601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="90239at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000115">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="96"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001070601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27346" checksum="3FCB8C99E359629F" modified="2015-12-09" version="1">MKNSYYAVANGYTPGIYSTWKECEKQIKGFRGARLAVFFKFKKTLSNSSQGTSREQTTSKRKFVTSDDDIAKLKRYKSTLYENDCANKILRDFRGDIGAPIVYTDGACSANGRRGAKAGIGVFWGDDHPDNIAEPLKDGPPTNNRAELMAVIVAVKQAVNKGLSCIIIRTDSNLLIQSMNNWIKSWRLNGWKTANGQDVKNKDLIVELDKWLKRVRFEHVAGHAGIYGNEKADELARKGAALYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM8</accession>
    <name>A0A0N4URM8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4119</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000306">
        <property type="protein sequence ID" value="VDN54146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM8"/>
    <dbReference type="STRING" id="318479.A0A0N4URM8"/>
    <dbReference type="WBParaSite" id="DME_0001071001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001071001-mRNA-1"/>
        <property type="gene ID" value="DME_0001071001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001071001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30637" checksum="6F1CA936B94151A1" modified="2015-12-09" version="1">MNSETTVLLPTKGLVALVTGGASGLGKATVEFLINRGLKVAIVDLPSSNGADVAKSCGENCLFIPANVTREDEVKAAKFKKNQVTREDEVKAAFGILCENFGRVDVIVNCAGIPGKLYDSVKREMQSLKEIAETVNVNVIGTMNVIQFACQMMAENEKDKDGQRGVIINVSSICAYDDNSLHAYSASKGAISSMTSPLAFEFAKHGIRFMAIAPGLFSTPMTTNLNNIKVVEKRIEYLKNIVLSPKRFGNPLEFAALVHHIIENRYLNGEVIRLDGGLRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USC4</accession>
    <name>A0A0N4USC4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4347</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000891">
        <property type="protein sequence ID" value="VDN54374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USC4"/>
    <dbReference type="WBParaSite" id="DME_0001095601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001095601-mRNA-1"/>
        <property type="gene ID" value="DME_0001095601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040517" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001095601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8046" checksum="A87A0DE1FA77A56C" modified="2015-12-09" version="1">MLLYFCFFVFLIHGVKSGDKEIENCNREVGGRQRPTVDPSRCAKIDSPACTAIFPYNPPDRAGDTIATHFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2J2</accession>
    <name>A0A158Q2J2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4588</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2J2"/>
    <dbReference type="STRING" id="318479.A0A158Q2J2"/>
    <dbReference type="WBParaSite" id="DME_0000022801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000022801-mRNA-1"/>
        <property type="gene ID" value="DME_0000022801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1278353at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02677">
        <property type="entry name" value="MIT_SNX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051866">
        <property type="entry name" value="Intracell_Sig-Traffick_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508:SF8">
        <property type="entry name" value="LD24550P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="279"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000022801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60658" checksum="6DBE39D41D6BCD8B" modified="2016-06-08" version="1">MAVLLDQAFCTTDLGRLLFQSRVLWDFHADITNTTTAGTLISQHTEYQLLITVSLFMFRHPQSVFLKLHLREVFPSFAPAKLFGNTGPTVINERIEASKRFLNFILKNEVLRKTKILHQFLEVISSLLHSDDINYYNATFNVDRASCSEQNTIRRPSVVKRIPRKVATSYRTDYLIQAAQLISVAQKAELEKAFELAFYYYKSAVNALLQGVQCECDLPKRNAVRKKTAKYLLKAEELYRSYLSFDGSKFDPDSWIGYSVQDPTLIAFQSSNAGLKFYNIVDILPTVNAKSRVYLAVDRPGSTKYVLKLLEKSEYGDAQKHFTIVPIGVANMVQLFKFFDIDNFIVLVLEYISHGLLFDFLVRYLLIQFLNHYLKFFSSDLQPKNLLIDDYGNLKLTYCGQWSNIDKRIDESAIDNHYVAPELRSLTNVATDAADRWSVGIIFFELLCGQSLSSLCFHGLETALELPILDYVEINFVARDLLSRLLVINPLERISDDGMRSHPFFGDYDWPVYDSAISFRNKHSNLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3G2</accession>
    <name>A0A158Q3G2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6700</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3G2"/>
    <dbReference type="STRING" id="318479.A0A158Q3G2"/>
    <dbReference type="WBParaSite" id="DME_0000234001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000234001-mRNA-1"/>
        <property type="gene ID" value="DME_0000234001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771911at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MATH" evidence="14">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000234001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="669" mass="77771" checksum="89854538E0FFAB44" modified="2016-06-08" version="1">MQLKIRNFQIENAGSIIKLSVPGNCMRSNVFRESNQSEAYWQLCLYPAGKRVENANHVSLFLKMSSTSPTKEMSLLEVYGSVFGFENIKVTLNGMYGNIKRSGFPQSLVKFQIKVEYRFYFLNERDFPVFSNVNVGEFHAKPPKGGHSWGLRNIPRQKLSSFCHICHEYVKQQEMALETGVQADCMLECNGQLIPVNRFCLCVHSKVFNAMFSYENMLENKEKRVVIEDTDVESVKMMLKYMYCGYVDLGTNAEEVLKLAERYQLDQLKLMCEEKISTNVDRNNVVDMLLFADLYNCKWLKSIAVEVLRTNKSYILKTAAWQNLKETNPALVTEVMEEVLLDDCDSPPLKRKCDYVMFFERNGIISRLRFSDLNHGPEKAKRGSGFKSWPYQTMGRVDFQLMRYLQPLHYRVLTAVEMGMKNHELVPLHIVAYIAGTHRGAVNCALSQLREYSAVIYEKGKRFDGYRLTQQGYDFLALNALHSREIVGFVFEKIGVGKESQIFLAADAKRDNLVLKLHKLGRTFRKLKEKRDYHNRRKFCSWLYLARLAAENEYKFLKVLYENDFPVPRPIDICRHTVVMDFISGVTLCNVRTVDKPEILYDKLMSLIVRLGECGLIHGDFNEFNIILTEEEEPVLIDFPQMLSIDHENADFYFDRDVGCIRKFFIRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3J4</accession>
    <name>A0A158Q3J4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6888</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3J4"/>
    <dbReference type="STRING" id="318479.A0A158Q3J4"/>
    <dbReference type="WBParaSite" id="DME_0000252801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000252801-mRNA-1"/>
        <property type="gene ID" value="DME_0000252801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="184"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000252801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31560" checksum="5D44C44A9202B860" modified="2016-06-08" version="1">MYIEGMSSFRTQTMDFQLDVYFQQFWKDPRLAHNESRRILIRDRTILSKVWHPDIYFANARIAEFHQVTQPNFLVWIEPDGSILYDTRISMVVMCMMNLAKWPLDEQRCYLRILSYAYDIELLRIAWQENEPITRNMKIAMSDMRIVDLKPGLCDGNYSTGIWSCVTAEFYVKREMTHHVMQSYVPTTLIVMISWFSFWLDVEAVPARVSLAITTLLTLSTQANAARMALPEVSYMKAIDVWMGTCMMFVFGVMIEFTIVNYAQRQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3U3</accession>
    <name>A0A158Q3U3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS7365</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 23">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3U3"/>
    <dbReference type="STRING" id="318479.A0A158Q3U3"/>
    <dbReference type="WBParaSite" id="DME_0000320601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000320601-mRNA-1"/>
        <property type="gene ID" value="DME_0000320601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="18">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN57392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000320601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="696" mass="79094" checksum="141328AE6890145A" modified="2016-06-08" version="1">MDSKIKLNYKNIAIIAIVSILININTLNGGFVYDDQQAIVSNEDVTGKFSLKSIFSNDFWGVPLSHTGSHKSYRPLTVLSFRLNYALTGSQPFSYHLVNVLCHALASIIFIIFVDRIFEMQKVSKLFCGLLFCVHAVHVEAIANIVGRADLLATISKMAPPIIICAIGILFKETAIVALPLLSIFAFFTANKGRLNRILIFLLSTLLFAIIRLWIIGFNAPRFSSSDNPAAHSTKFLTRLLTFLYLPLFHAKLIILPLNNFIDSMQSMLSLSLLILPHIIASNLFFYVGFVAAERILYLPSTGYCIFITLLFERGQLLLNLFYIVMIISHSIRSLNRNAEWTDEESLYRSAIHLNPAKAYANLGNILAQKGLKDEARKAYLQSLQHRPNMADTHYNLGILYQNENNYENAVKSYQSAIFYRPNHASAHLNLGLSLSLINETNSAYEILKKCLQLNSENLKNPLLHKKIQMACAYNLGLLLVESDKLNEAIKYFQLAIKFIQTSTISSNIASIYNMLAETYFKLGQYTNAENFYTKALAASSKHISAYVNMAKLRNHEKKHSDAIDLLSKALEINETRDDLHYQIALQYFEEKNYSLSLYHLITANRINPNNINFINALANLYRIINRKFDAEIYYKRVVQLNPNSSTSYANYGAILHLNGKFREAENMYKKAIQLNSNNQICKDNLMKLQKMRMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4F3</accession>
    <name>A0A158Q4F3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8617</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4F3"/>
    <dbReference type="STRING" id="318479.A0A158Q4F3"/>
    <dbReference type="WBParaSite" id="DME_0000473401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000473401-mRNA-1"/>
        <property type="gene ID" value="DME_0000473401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000473401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57133" checksum="D69ABDC74CC46E19" modified="2016-06-08" version="1">MVAKNFIPLLEEEQVNSSKKTKLANNNESDVVSIGHSLNGNKYVSLPQRFKVISHPNEWTEIRPSQTCSYIVWDKCTNSASCDFESLNSSGVECSNEEYPDLLSQTTASLYKFVLRKWEPIRVPVPVSGTNILVCSYNVLCQDTANRHMYMYTHLSKNNNEGKMQWSYRSPMLAHEFCTIDADIVCLQEVQNDHYDNFYKFIFKAAGYHGEFKKKTGSSVDGCAIFYRSRFECLRYLPIEYYVDKNCILNRSNIGKGVYFIDNRQIMRLRDKLSGKEFCIANTHLLFNIKRSDIRIAQLIILLAHLDKECGFFAFKPCPAIICGDFNLSADSPVYKFLLGERVSLEQNDESVGSENNFNQYSSFDLVFRQLNIGKNCRFFHNIDDGDHSSCQRYWAHSFKLADAYAPLSPQQKDVVSSYSSVGASCPDFIFYSVQSKYSQWYGNVKKTEIFENDLYLHRRLSLPTLSSLQSTFGPWPNAATPSDHIPIVAEFTIDSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4G5</accession>
    <name>A0A158Q4G5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8687</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4G5"/>
    <dbReference type="STRING" id="318479.A0A158Q4G5"/>
    <dbReference type="WBParaSite" id="DME_0000480401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000480401-mRNA-1"/>
        <property type="gene ID" value="DME_0000480401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="125"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000480401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43516" checksum="878D6D6630E5A7B8" modified="2016-06-08" version="1">MEPEAIRPDRDKTGRQKNPRRNIMINNNKLSDNIIKKMSAVSMLTELPTYMDYDERQQQQQQQQQQQQQQTNIICRSESAPLETIESNNSNNNNNKNCENILSTLMEIENICNQLRDAQPIFTKINIKLSDAILRPSLIAPRSPLLFDGSQGMGDCKHFIDSIRRLTVLLFDYVNTLKPVADLNPSDKISLIRNCFAQFALLTATFHTVQNTLNDSLILLPNGYCFHRNKQFKTSKKSREDSVDDDDDKLLQLLDGRINSIKQSIFDQVINPMRRLRLTQIEMVALKAILTIDPNAAKLDNSSLTILAIARESVQTALYANIGSRFSSSEATARFGNILLLISNISVKFRKVSSALTSLCETTHDLIENFDPIIYELIYGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5L5</accession>
    <name>A0A158Q5L5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyco_hydro_38C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10139</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001203">
        <property type="protein sequence ID" value="VDN60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5L5"/>
    <dbReference type="STRING" id="318479.A0A158Q5L5"/>
    <dbReference type="WBParaSite" id="DME_0000770501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000770501-mRNA-1"/>
        <property type="gene ID" value="DME_0000770501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 38 C-terminal" evidence="1">
        <location>
            <begin position="227"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000770501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43632" checksum="671D85143FE07265" modified="2016-06-08" version="1">MWRSPIHGDYQFWLGYTSNYSFSDYRPPRNQIGTAKENVTKDYKYRLSKGLDQAEVCEKFLSFNVRPVMDYFQEVINKALTKIVRIGNGTIKFPEQVICRLINESICDITRKYSNFAIIVLNGNTRPYQSVIRVPYYHKCASVFDQKGKILPFQMNEVFIKSEQAATYELLIPVEIPAMGFATIFVVQKTNLINEMRCFKKSTSSPKLSFSQKTELKLKINENSFRIKNKFIELEFDTRGYLSSIQNLESGSISVLKQEFLIYHGTGISNTTNQPSGAYIFRPNGTISFPIASNITYNVVEGEMVSEVRQILNPWVTQIIRLYKTRPFVEFEWTVGPIPKEKADLKQSRLRDPEKSSFYEQSAIYIMECYRTCVADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5S5</accession>
    <name>A0A158Q5S5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10257</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5S5"/>
    <dbReference type="STRING" id="318479.A0A158Q5S5"/>
    <dbReference type="WBParaSite" id="DME_0000812101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000812101-mRNA-1"/>
        <property type="gene ID" value="DME_0000812101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851789at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF53">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000812101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20019" checksum="D928EAF9A87B96F2" modified="2016-06-08" version="1">MEGNLFTAFILYMFTLGFAIPVFLIILFYGLLVGRLFTRYHSSRVSQVPVNRIAIYTMAISIFFVVCWSPYWIAALYGLYRTQRPLNRPASTTFIYVMYGIHALPYVNSASNWLLYGLLNGQLIRRANIQKKSLVIDNKINEFNDKLVQSPNFFNSQRVVGRLSLLPNTTDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q664</accession>
    <name>A0A158Q664_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein bark beetle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000090">
        <property type="protein sequence ID" value="VDN52967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q664"/>
    <dbReference type="STRING" id="318479.A0A158Q664"/>
    <dbReference type="WBParaSite" id="DME_0000920301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000920301-mRNA-1"/>
        <property type="gene ID" value="DME_0000920301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790562at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041046076" evidence="1">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000920301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57363" checksum="A68EDA5F09072D08" modified="2016-06-08" version="1">MRMLPLLLVILWALIRTSGEVYKAFFTSLIFPEIHCINAIYVDCLVPLTGAEDIMRCFRNRCYYSNKNKKKHHHGKNCAQVDGCFHERKKREVAVTKLPNFASAGSPYQIQEDLIVPANHILRIPSSVKIAFANNVGIIVYGALQINGTQHEQVSLYSYERNWKGVLFHSINSNKNRDYKSFLNYVNISNSIYGLNIDGPPYPELSHVVCDGNENGMTIRLTHKERAPGTDLKDIACCTFMNMLTAARKILQTFFNIDHIDFLFQCEQHTVPCFTMDGLSQIHLPQMRLYFEEVILVDALLLSNRNDGLLVNGSLALRIFSSQFSSNGKNGISAQFSPNSSFEITNSFIGSNGDAGLCILPDYRTRIKILASNFTAHYYSAAVIVEKSMKIDFLLEWSHIWNNNASGIIFKKNISQSDIRLLNNNFTRNYGDVMHVEEICNAANIQMENNRFSHNQLSKRNSMNTVIGLRIMQDGQELQLQPIVSRGDIVIIGEDWNARVSPDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6F6</accession>
    <name>A0A158Q6F6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3510</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000142">
        <property type="protein sequence ID" value="VDN53537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6F6"/>
    <dbReference type="STRING" id="318479.A0A158Q6F6"/>
    <dbReference type="WBParaSite" id="DME_0000995901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995901-mRNA-1"/>
        <property type="gene ID" value="DME_0000995901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23550" checksum="B9DC1ECE3BE6927A" modified="2016-06-08" version="1">MDELKKRHQKQRESIQKQQQTNVDKLICDSNKQSKKRTSNSLTVEQHMALSTRKSDPSTFMANSYRMRSLVSTQTDEWSAMMKRHENECHELRRTHIKEEFDLLNKLLLDAQKQQMNALKMRLETENKELKQTQTKKSMEGVRAIHQDKNIKTKAEKDRRVKEMNEKNLKMFFEERKRLAIKYAFLVFLEMKGDISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PGF7</accession>
    <name>A0A3P7PGF7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000242">
        <property type="protein sequence ID" value="VDN54025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PGF7"/>
    <dbReference type="STRING" id="318479.A0A3P7PGF7"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="260" mass="29008" checksum="557398C25E96FA0D" modified="2019-02-13" version="1">MSHADDALSLNIPEVNEEVFGWLKKIIKHTGLAVLNISDHIINLLTQYCRPSTNFYSCVRALDYGEAFADAVSSFLIYRTSVWNVHDVKELQQWICHEVLLNPDSIPALRILIALLACNHELVPIPIEVKYFSLISVNQNTLKIAKYSIDERKKTAEADQTGTYENFAHITNSSNFNGKDKSKQEDFAVNLISNNVDPIDIIIIESDVAKNKASSHPNQNARTVGNCNSDAMPRKGQTVITSTDGNEISVEQMLADFDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PKG9</accession>
    <name>A0A3P7PKG9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PKG9"/>
    <dbReference type="OrthoDB" id="5791021at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="111" mass="12625" checksum="345A9FB9064B3F83" modified="2019-02-13" version="1">MIGFIAIFASSFIWNQSNVYFQLGYRGFGWQTLILAVLIVTWFLSLIILFSQFADRDILVNLGKYKVLCLYACCCVALFIAACLESWYCKLAYGDPILHPRFVVVTVSCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PKH1</accession>
    <name>A0A3P7PKH1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PKH1"/>
    <dbReference type="STRING" id="318479.A0A3P7PKH1"/>
    <dbReference type="OrthoDB" id="10070965at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="181" mass="21225" checksum="F1AE8901F3CE8B45" modified="2019-02-13" version="1">MSTFPFIKIYFRTSEDIEELQCEYERYRILILNEFEKVPEHIFLQEIAQKEFWPVDPVSQSVRVEAEKKKQSREKKAAVAFAYEDTQTVGGKPESDESEDDDDEFIEPEEFDLKFDVDALDPERIRSLNKFGMKYGIALGAFSRLLKMDRREQDETHQLKEIEKAKLALAVCNSILIIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PLU7</accession>
    <name>A0A3P7PLU7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PLU7"/>
    <dbReference type="OrthoDB" id="5832893at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="66" mass="8024" checksum="FC5CA301B3ECBDC9" modified="2019-02-13" version="1">MRRFLIRYPQGPFYIVGGLILSGFSFPLFQALYYRMTMNKEDFIEMQERRRKEVKKLLVSGKFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PV47</accession>
    <name>A0A3P7PV47_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TspO/MBR family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PV47"/>
    <dbReference type="STRING" id="318479.A0A3P7PV47"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10588" checksum="1B9CE83BB30332C2" modified="2019-02-13" version="1">MLTLSTLGPASYLVYKHGGGFDYSDTKLALGLYGANLIFAAAAMPLTKLRNLKGVIFFIFKVHKTAGSLILPYSLWISFYTVLLYFMKSEEPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PVF7</accession>
    <name>A0A3P7PVF7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PVF7"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF87">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="188"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="767" mass="87844" checksum="3977738E36265674" modified="2019-02-13" version="1">MTFKFDFKVPITSRDEGNLLRDGYLEEVEELSFFIQHNLTVQCDLKSSGFCSFQDICSGNCNDNQVIPIFRLIYRNDSRRFHPNFRLTYPTMHIYNDEYYIGEHFAGISVNRTTNRISKIKLVISFPNLLKLHIKNFKNSFRWEKKLLSYVQSFRHPFINISCSSDGLFSHEVRRNGISCIPYFILSVTAVFSFILITNQRSNISEGLFIAFVGTIGPLMAICTTFTVLLAIGNEFNSITLVVPFLIMGVGCDDVFIIVHAWRKTSSNDLIVTTMSEAGPSITVTSVTNALSFGIGILTSTPAIRLFCIYATLGVLIDFIYQITFFGAAMVYQGPKRIVNESKASDNNRINRWRLMVFAFVITYWLVSIYGCLTMPVKMDSTNLLLRDSPLNNVAWLYEKYLWSEGSLFFVFINNPPELRYENNRNRMLNLVKRFETLEYSMGHNSTSIWLRSFLSQASLYENEQNNDFYFLLDDWLTDEGRRWNDFIRVERFNQTIIGIKRFFFATAIAMGNHSSWVLRARLQNAWRDLAFFYQQYNVTVYQPYSFYVDQLNSIRPTMISTVITAMVAMALICFLTIPSNLSIIFSCLAMLSINIGVFGGLSLWNVCLDPLTMCTTLTSIGFSVDFTVHICYHYYRCSSSKIPEERLRDALTSIGWPMIQAGLSTVLCVSPLLLVDSYMVSVFLKTIFLVISLGLLHGILFLPSLLLTVTPLNITKKKIQNEPGKKLKTHMDSKNTFVSPNSNPSLKHQFKLTSTKLPRLIHNSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYX0</accession>
    <name>A0A3P7PYX0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the CIA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYX0"/>
    <dbReference type="STRING" id="318479.A0A3P7PYX0"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="782" mass="89294" checksum="3DBE2F77C551EB0C" modified="2019-02-13" version="1">MRRCIFSLGVPKMNRILDNISNDDIVKESLRLLVDEHSLSLSTFIELFKPRLTSFDANERDKAIHCVATVLCNLPKDFLNAEQVKLLLEFFLDRLEDCSISSEIIINAINHLVCKVCLLPMDYELKIFNKLFGDLNIQSFSPKVREELYEILEFLLIFHLKGMRTVGVDCALCFIRAASGEHNARCLLIVFRVFCLIVKNLVLGPFLNELFDIIASYYPIEFNPPKSDKNTITRDVLVAGCEECFLAHSGFADLTYKLIIEKLLDDETEEIGKIEICLFLVKACVFYPVAPLRNHLDGLLGGLRAVALNPSSDAESVSIPVHSAIQAIALKFLDHSEDSLDGMEQICNCELFVLQAQLGLMNRALDLLEATAKVDKSAAQIILPQVLRWLLMICRGDSSNTSSNKVSVITDGLNSLPIWLNLLKKNKDGINCHKICDEFIDFLQNKFCFVDEVLKYSTKYVVAETFMQLIHLENYNLNKLCECLLMRTVADINSSGEQLRRYCSSFISGFAQCNWQKNNSRFFLKMEALGLNSENEQLITHVFRNNVDNVKICKDFLVHTLNIFLTMDHKNVEANCLQQIGLIIEESYSNGKLREYEKKSLEWNSVDIIRFKSRVCLSLLFAGRVQGLKYFEDLISAIVYNQENTNILVSELKNIFDFESSSNNPDKCRISLISDNRNIQLQFYELLIPILLMLQDISTFLTLEYTMLLPIFRDIFDKSGNDSYATGWATFNAIRCFELLARRWPVTTLMQYSNQVFTALIKATGSHKRVIRTAAADVRNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QAF8</accession>
    <name>A0A3P7QAF8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QAF8"/>
    <dbReference type="OrthoDB" id="189688at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="49" mass="6041" checksum="4A6C9C7A366040D7" modified="2019-02-13" version="1">MYFFQRFGFHFLLFLIKLISMVARTALLLSNPEYQSDSEWIRERIRQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SQR6</accession>
    <name>A0A3P7SQR6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000097">
        <property type="protein sequence ID" value="VDN53049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SQR6"/>
    <dbReference type="STRING" id="318479.A0A3P7SQR6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="208" mass="24386" checksum="314F31A16E60E95B" modified="2019-02-13" version="1">MSILIVVYCSHFGSIENHYHIFYCSVGTNGTINYLVMDLMGPTIEDIFIYSHREFTFKTALALGIQMLKCIQQIHAKNILHRDIKPNNFVMGIKKNCSIMYLIDFGLSKKYQDVDASQVDTDHPSDKVNLTLEITFDQTLLWMKISFEFFDKYLYNNLQELSEGCPAEIENLIQYCRNLDIDEIPDYDGIFKSLRNLLRTFWQQVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SYY2</accession>
    <name>A0A3P7SYY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SYY2"/>
    <dbReference type="STRING" id="318479.A0A3P7SYY2"/>
    <dbReference type="OrthoDB" id="5875090at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="103" mass="12335" checksum="B20BC5A750FDFAF0" modified="2019-02-13" version="1">MFYYDFQELLISKWESFLQARSVKLEDLSNSICCIHHVFGENKGKQFISDGWLSSKNQNEILLRIHGDPFNFFTKAHAKRSYRLKVTPFDVRHKEVYLFIPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T3B7</accession>
    <name>A0A3P7T3B7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T3B7"/>
    <dbReference type="OrthoDB" id="5869600at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="62" mass="7339" checksum="31D2B32195898AE7" modified="2019-02-13" version="1">MAVKRILPKNHLEITDDRNFAEKLFIFQICASLNEICSNHRKRPKIYQFNSFDTEGIEIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0H8</accession>
    <name>A0A0N4U0H8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4418</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0H8"/>
    <dbReference type="STRING" id="318479.A0A0N4U0H8"/>
    <dbReference type="WBParaSite" id="DME_0000005801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000005801-mRNA-1"/>
        <property type="gene ID" value="DME_0000005801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876240at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000005801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48718" checksum="F9DB5E701BDCA82B" modified="2015-12-09" version="1">MYEITAKLIQSCGKIILQTFLILDKRSGKWATTFALILGLLKETLLKCTYGNCQKILSNNINFMFHLWSHVAQHLSNGGEFQADIRHLCTCPHCLHISPNPYRLYKHYYNIHRDGDSKNVCPICEITVSVKHSVIHGSYDAPYHCRRCKFRTSCRSLFIDHFTKFHFNTRDLLCPFCLITYKVVGEASSIVRKPGYVSHFKAHLKQTRFECKRCALKFLTLSQKKAHQRDHLKLNPKWISRNFCLQQRRRFEELWVPSSHSKCIECGEDPGLVKEHFKYEYCCGKCSYKTNCYQAMGNHKFIDCCRKRVGMLRKHLLQNLVICSKCGRQSCDPEILEHIYVCGNGIALNGDEVLASLEAEQEVENKLFSTRFEPLNDFSKDRTDDMYDEFLKRVNAAADPDCLHNAKISFMLRIQITGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0P1</accession>
    <name>A0A0N4U0P1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4487</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0P1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0P1"/>
    <dbReference type="WBParaSite" id="DME_0000012701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000012701-mRNA-1"/>
        <property type="gene ID" value="DME_0000012701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF4">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="122"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000012701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48386" checksum="EDA14589E24DEAC8" modified="2015-12-09" version="1">MNSRESRLNEWKIAPKNLENNILETLKRQTNEEQYQYQLNEFEVGKLNKKTELEVGERIQHESENKSSFYENRIIHFDLKGAAPKIDYLKKVFKLIADAGATGVLIEWEDMFPYTGILKDSRSTQAYTLSETEEILAYANNLQLTTIPLVQTFGHLEWILKSDKFMKYRENEKFPQVICIGDEEGVGLVKEAIKQVIKVHEKYGVPFFHIGADEAFEFNVCKKDVEWAKNNSHIGSGKLAPFHISKIANYVISLIPGVRVLAWYDLLKTFSLSTVQEFKLDTLLEPVVWDYSESLIQQNARSWTLLSHLFPTVWASSAFKGANTPSSQNLDLNHYMRNNQQWILHKRLYGRLFKKNFQGIIITGWQRYDHFAVLCELLPVGLPSMIINLQASNVNIFIQRFSEIFSIHDVAICEYDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0P6</accession>
    <name>A0A0N4U0P6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy-related protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4492</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0P6"/>
    <dbReference type="WBParaSite" id="DME_0000013201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000013201-mRNA-1"/>
        <property type="gene ID" value="DME_0000013201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000013201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15308" checksum="C5237114A5419AEA" modified="2015-12-09" version="1">MFNADDKCKILWEWFENLFILRLALGYSDSFALRSRFSRDFRMMTSLSSNDLDLKCWDTELGDYHRFYIDNFEDPTSLSYRSETLQHNQPAEGQSSSNSFSNGQFDQSYTDDGNLRAFESVFEVSIGVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U154</accession>
    <name>A0A0N4U154_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4676</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U154"/>
    <dbReference type="WBParaSite" id="DME_0000031601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000031601-mRNA-1"/>
        <property type="gene ID" value="DME_0000031601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868397at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000031601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34108" checksum="40DA0BCDA2D0EC08" modified="2015-12-09" version="1">MNNENHQLSRVEELRRLLEDSLKIDEKIFHNNSKFTVSSEVIQKMLRPLKILYRNDRRAIIQISGPSSSRKKDNNSEMAESSSTVVLKHNRSISPAPLEVIVGVTVSNCNSINTATIEQKLSVNDSSTSSPVGSVDSGVSLSSPSISPISSPINTQNNLFCLNTANSEDLPHCLRQRSTSDSVSFGLKSILKKTPVVYRGRFISRSVSECEHSEALNSITGGLSSEMLQEEGETTESTEYINRKKRVSFSERLVKEHCFRPNSSILGQKKKNQRKIRNKLKKKANEEVLNCERKSNDKNNVLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U194</accession>
    <name>A0A0N4U194_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4720</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U194"/>
    <dbReference type="STRING" id="318479.A0A0N4U194"/>
    <dbReference type="WBParaSite" id="DME_0000036001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000036001-mRNA-1"/>
        <property type="gene ID" value="DME_0000036001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000036001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55481" checksum="1717822414469774" modified="2015-12-09" version="1">SLSATVEPNVTSYQFDNLIGNTTYRISVEGFSNDRSVLYTSAMISTSLAVLKWLPAPSDITLIDKSWDFMEIRWTAPIVASARTQAMINQHLRYKLSIQLPTTKVTFLNLDPRTVYNVTIQASTEFGYGDLGWATYSTLDVNEDFILRLKTRTPNSLTIKWPASWFDTPSTRYTGTRILHSIVGSEKEISISSYNDGHVPEHLLHDLEPGATFNVTLIYIMEVYIANVLDPQPESALQCPKVGCDWLCLLIFNLAENPREYTFDIRAQVAGVWNKWVPIARRYMSFPSVNSLCSINPPLSFVANIGKSDFMREIVIEKDSMNDPNVWKYLVVIDRRVEGDIIGAVDISRLSDKVTSDHENIPYYITAALIPEYFNYKIPFRIGDGQVYGGYLNYPLDKGLNPRWFLIPLSQTESEIMEPTLKYCGFREDGTIECELSVAQLLSFVPWWLGLLVSLIIIFVMLLVLLIIFKFFQRQFCKFIVSFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U278</accession>
    <name>A0A0N4U278_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5121</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U278"/>
    <dbReference type="WBParaSite" id="DME_0000076101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000076101-mRNA-1"/>
        <property type="gene ID" value="DME_0000076101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000076101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11330" checksum="90DB222DBEDADC2D" modified="2015-12-09" version="1">MGCGNSSNQPPPATPEISKLSCRNFQRKCSVLPENNQNSRPWIIKNGNHSSNFTTAASPNNSLKNNNVKHFQQRRQPHQHHQFVSKIIISPSSQSLLSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2A0</accession>
    <name>A0A0N4U2A0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein rogdi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5151</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2A0"/>
    <dbReference type="STRING" id="318479.A0A0N4U2A0"/>
    <dbReference type="WBParaSite" id="DME_0000079101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000079101-mRNA-1"/>
        <property type="gene ID" value="DME_0000079101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000079101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32093" checksum="9C6E419F5CA6859E" modified="2015-12-09" version="1">MKLVLQIIMTENDSRINEDVGCSDEAAVRKQLIINENIWFQRNFGSRFLLELIIKACCNQLHSSNKLNSSEITSKALPEKIQLSQKNGQDVLRVSVTLLAENILQTEVVLKYPKMPGGIYKSSAQPDIHWKLQQLLDVGNYCVKALNAIIKVILDNNIKANMFAGEGINKLINLARSTLYLPRKRTLLELCNFPPNRCFIPPLPPDLVFSYYIGSTRLICAAYYTSFKANGMQNLSVIQSECQLPYLVDLLFSLNKALNTAQQFRYHLKLLNSSSEDEFTNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2G6</accession>
    <name>A0A0N4U2G6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5229</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2G6"/>
    <dbReference type="WBParaSite" id="DME_0000086901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000086901-mRNA-1"/>
        <property type="gene ID" value="DME_0000086901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000086901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11741" checksum="94F8320651530946" modified="2015-12-09" version="1">MRRRNATGLGKLERQELKKVTGNVVAAVLSCRCHCCPLATPQVCHSGASTTQFPWALRGFGSILRGGLQILADCRDCQMRLSIFMTGCSAAKLICMPYMASATDFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2R4</accession>
    <name>A0A0N4U2R4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5347</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2R4"/>
    <dbReference type="WBParaSite" id="DME_0000098701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000098701-mRNA-1"/>
        <property type="gene ID" value="DME_0000098701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000098701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8935" checksum="5B6073D896294F6D" modified="2015-12-09" version="1">MDGWQGYDTILCGLQVCPYETAFYYYYCCSGLFGLGGCCYSLKAWVIVLIIILVILFLACAAGCIGILLYRQSSRRNEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U380</accession>
    <name>A0A0N4U380_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5535</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U380"/>
    <dbReference type="STRING" id="318479.A0A0N4U380"/>
    <dbReference type="WBParaSite" id="DME_0000117501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000117501-mRNA-1"/>
        <property type="gene ID" value="DME_0000117501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="27"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000117501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27257" checksum="3A54BBA3B1655C9F" modified="2015-12-09" version="1">MQRAIIEKNDAMIVNWSQNWLSARDKRIIWIDCEMTGLRRKDKIIEIACVIVGEQIDIVVHQPENVLADMKVWHKNTFAANGLLDSIRSNRISRISIKEAEKQVLFFCANAKLDLFYFYIFSQFSQFFCQILNHLTKYTRKGKCPLAGNSVSVDRMFINREMQNLAAHLHYRTIDVASFNEIVKRWYPEKYASMPAKSGKHRALDGILESIQELTWYCRNVFAETEIPVQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3E9</accession>
    <name>A0A0N4U3E9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS5612</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3E9"/>
    <dbReference type="STRING" id="318479.A0A0N4U3E9"/>
    <dbReference type="WBParaSite" id="DME_0000125201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000125201-mRNA-1"/>
        <property type="gene ID" value="DME_0000125201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN55639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="DME_0000125201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25977" checksum="6C7578F92B612535" modified="2015-12-09" version="1">MEKVKDGCRQFTAGGTAGLVEVCIMHPLDLLKTRLQIGSHYKGLIDCIFQTFRNEGPTAFYKGILPPLLAETPKRATKFFTFEVYKDLFNKPSIDPSLSLSLAGLCCGLTEAVVVNPFEQKSSAALAREIVRIDGIGKKGLYCGLTSTLARNGTWNMIYFGLYHNIKLYVPDAAENPMTNLFGRVALGFTAGTLASVANIPFDVAKSRVQGPQPELGIRKYHGCWQSMKLIYKEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3R7</accession>
    <name>A0A0N4U3R7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5738</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3R7"/>
    <dbReference type="STRING" id="318479.A0A0N4U3R7"/>
    <dbReference type="WBParaSite" id="DME_0000137801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000137801-mRNA-1"/>
        <property type="gene ID" value="DME_0000137801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000137801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27147" checksum="CD6D1CC15039E673" modified="2015-12-09" version="1">MLSKRILNVWMTTGMSVHRYIGVCLPFKASSILQPNHVAVFIIGLLGFSVLFNSTRFFEVRVVNNCYRLNIAAFIPVLSPSDLRLNPTYRLIFFGWAYTILMFVVPFSILITVNSQVLFTIRRSNRLHRRISMPDDSSKRAERKERQTSIMLIAIVVVFLSCNTLAFVVNILENIGYDDAFYANLVTYNNFLVMVNASCNIAIFMLFSDKYRLLLRHYLACDWTRDAEIIVTTTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U406</accession>
    <name>A0A0N4U406_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deubiquitinating enzyme A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5847</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C85 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U406"/>
    <dbReference type="STRING" id="318479.A0A0N4U406"/>
    <dbReference type="WBParaSite" id="DME_0000148701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000148701-mRNA-1"/>
        <property type="gene ID" value="DME_0000148701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22752">
        <property type="entry name" value="OTU_OTUD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000018">
        <property type="entry name" value="OTU domain-containing protein 5-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF4">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000148701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27322" checksum="32C8BE4A5ABC45CB" modified="2016-06-08" version="2">MFRAVADQVYGDEDMHDEVRRLCLDYMEKNRDHFSQFITEDFDQYISRKREKGVCGNHIELQAISEIYSRAIEIYQYSADPINIFNPRVDISSSSKPNAPIRLSYHGSSHYNSVVDPYEATIGVGLGLPGHSPGSADRNLVREAILKSESQLIEDAMLKDKIRLSDFECTEQQISEQVKNFLNVSYFKVSEWSRAAQDDAEEKSLLAQVMALSQQEYLNSLIKKSTKRNDFDQAGSSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U437</accession>
    <name>A0A0N4U437_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U437"/>
    <dbReference type="WBParaSite" id="DME_0000152501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000152501-mRNA-1"/>
        <property type="gene ID" value="DME_0000152501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000152501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26169" checksum="03A43C9959CA8A01" modified="2015-12-09" version="1">MLNGQATHDHGYCDSECNTDKSLSTDIPCQTVQCITPVKCYKHSAALGSKERDNRFAPTFEISDDNWCHDDSNASDSGLCLAVTSARNENAEPNTDINKNLEINTDRNSVNLDSNDGIIEERAGNLTSAYEEAERTANFMKRNSPSLVECLKTTNDGISEMATNVSGNMESKVLQKIDDSSRNEGQCATTRIPLRKLRLNFDFSPIDDDNLLLNFQLKPKKIITYKIQPFNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U467</accession>
    <name>A0A0N4U467_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5923</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U467"/>
    <dbReference type="STRING" id="318479.A0A0N4U467"/>
    <dbReference type="WBParaSite" id="DME_0000156301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000156301-mRNA-1"/>
        <property type="gene ID" value="DME_0000156301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000156301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62771" checksum="A0912E48F4B50A24" modified="2015-12-09" version="1">MAVIGGFLFGYDTGIVSGAMLYVARSQAMKPLTNNWKELIVGITPGTAAIGALIAGQVSDRYGRKKTIIASSTIFTTGGLICGAALEKISLFIGRFLLGFAIGLASMVVPIYLGEASPSHIRGTLITGFQLMITFGLMAANIVAGIKSGFSYIDPENVGWRLMFGFAALPGIIQFIGFMFLPESPRWLYANKNNEKTTSVLDRIYSGNKEWIEYEFAEISGCVEMEKKCKEENGSSTILRVLTTPHVRKALIIGVLLQAFQQLSGINTIMYYTGTIIQSAGLKDIRLTIWITVGISAVNFFSTFIPMYFVERVGRRKLLFVSIAGVAISLIAMGISFLLINTDSGYTIPHDKIIVDSSVQNYQDCKSYSNCDYCVTDERCGYCHITDTKSGYCLPFDLIDHDKSSTGPCMDMNNITNFTWTSLHCATRFTILPIIVMVCYLAFFSIGYAPMPWVLNAEFYPLWARSTCCSISTFSNWLFNLIISFTFLSLSQAASKFGAFFIYGALTFIAFVIFYINVPETKGYNIEQIETLFMPKNRQNIVKSVDDFGYIGEKDEEHQKIDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U499</accession>
    <name>A0A0N4U499_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PA2c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5956</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U499"/>
    <dbReference type="WBParaSite" id="DME_0000159601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000159601-mRNA-1"/>
        <property type="gene ID" value="DME_0000159601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5781547at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228:SF6">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000159601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33185" checksum="01D34B436F139877" modified="2015-12-09" version="1">MISIGFTISHKLATFENWQKWYCGSDDETRRHSYKTIAEECPDVLDQFNECCWVHDQCYADQLGKINCDNHFCQCLDIIAMKAKHYDDCKMNAWWACFAVQVFGDHAYVASASQNRTMKTSTVTKKDTTTTNAPTVCVIDDEEVHEHYKMASNTCRDQKNEFTKCCEQHTMCHRNLSNNPKFCHKAFASCLIDHINEDNNSDSDCRKAAYLIYNELSGEGSDEPKECLQLKIACSAGHYFLHQRRLGLEFRRGVFQFDKLNGVLKDLLKFLCLPVPYINIPQKRPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4R1</accession>
    <name>A0A0N4U4R1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4R1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4R1"/>
    <dbReference type="WBParaSite" id="DME_0000178501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000178501-mRNA-1"/>
        <property type="gene ID" value="DME_0000178501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000178501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16671" checksum="1DE3972204C7693B" modified="2015-12-09" version="1">MSITVIAVWNGDITKLQIDAIVNAANSRLLGGGGVDGAIHRAAGPELLEECRKLNGCCVGEAKMTNAYNMTHVKKIIHTVGPQIRNDVTEENEKQLKSCYINSLDLASRNNLKTIAFPCISTGVYGYPNDKACDTVVNAVKDWLIHHANSVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U522</accession>
    <name>A0A0N4U522_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6284</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U522"/>
    <dbReference type="WBParaSite" id="DME_0000192401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000192401-mRNA-1"/>
        <property type="gene ID" value="DME_0000192401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798901at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF44">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162167" evidence="5">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000192401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16165" checksum="90E144EC91A69F28" modified="2015-12-09" version="1">MMKGQALGLLVIFNCILSLATAFRSQSVWATGKLLCGTKPASSVYVKLVDKDRAPNPDDLLDSSNTNATGHFNLMGDSIEMSDIDPEIRIYHDCNDYNKPCQREWIIRIPDKYIFDGDIPQKPFDFGVLNLEVELENEYKKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5H6</accession>
    <name>A0A0N4U5H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6461</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5H6"/>
    <dbReference type="STRING" id="318479.A0A0N4U5H6"/>
    <dbReference type="WBParaSite" id="DME_0000210101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000210101-mRNA-1"/>
        <property type="gene ID" value="DME_0000210101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229767" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000210101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15247" checksum="FE5D2FB1B7118FE6" modified="2015-12-09" version="1">MKHLILFLFLNAHLGVLDGISKKKRDRTAPIKDEKLCLGSKIFREERDQILSLHNKLRSELAAGKVSTGNGTMPQGSDIRELRWDCKLEKTAQWWADRCLWKHSDVSDRNYKGENLYKVQQTIPIDRSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5U6</accession>
    <name>A0A0N4U5U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6607</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5U6"/>
    <dbReference type="WBParaSite" id="DME_0000224701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000224701-mRNA-1"/>
        <property type="gene ID" value="DME_0000224701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977011at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000224701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22233" checksum="03FD26C672AD3E6A" modified="2015-12-09" version="1">MSDVLCALFPDLKNEPTETIDSRHEKLTRPDFLEFSVDEQANNFKSSLINTSEEKLSPVTAIDMNDQSHNEMEDDITFTPITIESDLGGDIDVMEGSLMSMLENFRSGKMTILSDEILSHMQQARKEMEELTAFHIKLHRLQVPSTSANCDIDAQYDTLFRRLDNLHSFIRNMSFGNSKNETNENNSAVFHLGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U694</accession>
    <name>A0A0N4U694_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6786</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U694"/>
    <dbReference type="WBParaSite" id="DME_0000242601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000242601-mRNA-1"/>
        <property type="gene ID" value="DME_0000242601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855855at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041608" evidence="1">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000242601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19593" checksum="8DA5C9B70CE91971" modified="2015-12-09" version="1">MNSSQIYFLLLFFIVFCELSAKSINKEIFSSSEIATPDLIDSFIARTKAAGTNHHHRTHRRHRAMFKRNGSVGIDENGREYINCRKSINKNYAITKRCYRPTNSNDMELGCYAVWDEKNAILQQDCWIQQTISMSNCGVGKCTAKKSSFCCCFGHNCNDRIELSNRSLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U699</accession>
    <name>A0A0N4U699_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6794</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U699"/>
    <dbReference type="STRING" id="318479.A0A0N4U699"/>
    <dbReference type="WBParaSite" id="DME_0000243401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243401-mRNA-1"/>
        <property type="gene ID" value="DME_0000243401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="65"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39956" checksum="F134A54D9B16C55F" modified="2016-06-08" version="2">MLRQNNLFWIAAAISNILFMYWTILIYKYHLSFETKQLGNETVWKAKKNLHKNKIITRNENLPFCAENSSVFKGLIGIQKVSPDMKVMEKVFSMLAPGGHGEPRNCRARHRIAIIVPYRNRPLHRRLFLYNMHQWLPKQMLDYMVIIISQLGKEKFNRGALMNIGFVEAQKLYDWECFIFHDIDLLPENDRIPYRCLDQPVHLSAAISKYNYSIPYKNNFGGICAFTKEQFLRMNGFSNDYWGWGGEDDDAHNRVLLAGYSISRYPKSLARYTMLPHANQAGTSNASNCYTPSINETLSKWKKSGLSSLNYHLDSIKFLPLYLSIQVTLMDKGQERLLQNSSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6L6</accession>
    <name>A0A0N4U6L6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6934</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
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        <property type="entry name" value="TCRTETA"/>
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            <end position="88"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="464"/>
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            <begin position="32"/>
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            <begin position="478"/>
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            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54413" checksum="B2C176BB6C799B3E" modified="2015-12-09" version="1">MRRKSRSLFSLIFGPSFRQVRNTSGSFIGIASVRHALIIIFLEYFAWGLLTVPVINVLANTFPANKFLMNGLILGVKGFLSFLSAPLIGALSDTWGRRSFLLLTVFFTCMPIPCLMISPWWYFALFSISGLFSVTFSVVLAYVADITEQSDRSAAYGLVSATFAASLVTSPALGAYISEKWNDEAVVLLASIIAIFDVVFIITLVPESLSIKMRFSFDSFYWHAADPFASLRIIWEDRIVLQLAAIVLLSYLPEAGQFSCFFVYLKLVVGFSPESVAAFIALVGILSVFAQTGVLSLLTNSFGTKYTITLGLCFQFAQLLWYGLGTKIWMMWAAGLLAAMSQLTYPSISAFVSIQSDHDKQGTVQGVITGIRGLCQGLGPALFGLIFYHFNMDLETDNDDTGHFGIAPFPAPRIRPQQIIWPRKNITSTIRPQFNNHFVPGPPFLFGALLVLIALFISSSLPRVNSVHLRSSRRTPSHSRQSSADTATLIQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6U8</accession>
    <name>A0A0N4U6U8_DRAME</name>
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        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7035</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Spirurina</taxon>
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            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
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        <citation type="submission" date="2016-03" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
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            <end position="120"/>
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            <begin position="143"/>
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            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000267501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17602" checksum="3E49737B3FC2E45C" modified="2016-06-08" version="3">YSTFLACKRKEEQQLNGGTQPSAPKKPRLVFTDIQRRTLQAFEYSYASILRGLKVGILELIGRYLLHERCVPIKMLLQAIFKETKRPSREMQLTISQQLQLDPTTVANFFMNARRRGHDRTRQEDEHSTMITSNASSSQVLSPLPPPPVFEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Y8</accession>
    <name>A0A0N4U6Y8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7083</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4U6Y8"/>
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        <property type="protein sequence ID" value="DME_0000272301-mRNA-1"/>
        <property type="gene ID" value="DME_0000272301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="68"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000272301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28684" checksum="8FDE4AAD7351BB86" modified="2015-12-09" version="1">MNLNFAEIFSFPIRLSGQHSMNAKELCDFDDLANSIVVDSFLGFKTHKMNLKLVSLLLRFLLMFSPSSGFTIRPCTRYTAEKNRGAKLVVTRPWFFLYSNYFISFKITFFIKYLFEYSKTLNITLCLWLGPGAYINHDCQPSCKFVPKKHTVQLQVLRDMETGEEITCYYGVDFFGDNNERCECLTLNKLTNESNVCPSRYRLRETCSRLERNGNSISLRQNVYLRQGDQIDRCNKTNGYDFLVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7E1</accession>
    <name>A0A0N4U7E1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tenascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS130</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7E1"/>
    <dbReference type="STRING" id="318479.A0A0N4U7E1"/>
    <dbReference type="WBParaSite" id="DME_0000290101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000290101-mRNA-1"/>
        <property type="gene ID" value="DME_0000290101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000290101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="48178" checksum="8A3AEE5248EEE87E" modified="2015-12-09" version="1">MDVDDPFDSPCRSDLSRGISHCGAQPCIPRIGDTANYICLCPYNEIYDHGVACGQQYCLNGGSCDGKICKCPEGFVGNRCETDLCHNYCLNKGNCSITYDPISSSRAVPTCSCPIEYTGSRCQQYKCTGRCGAYGTCLVSQKTGLPICNCLPNYGGAECNRRIDACETYCFNGGLCSYDENMAPSCQCPAGFIGNRCENCMLAKGEIRICQNGGYCKDGNQCSCPAGFSGSSCETDFCDGHCFNEGICLPSVLNGVTHQLQCICPPGFGGSRCEIDWCHRNEHYCLHNGHCIHDRLKGIICICSSKFQGDRCKEERRCEDYCLNESECFSKSAYEWGCRCKAGYSGNRCDVFDKCSNQCHNGGTCQFDNRLGGVCECPKGIAGRSCTQIIARTCSEIVCLNGGKCMMTVLHGVQCSCPIGWGGLVCAEPECYGYCQNGGTCASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U819</accession>
    <name>A0A0N4U819_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7323</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U819"/>
    <dbReference type="STRING" id="318479.A0A0N4U819"/>
    <dbReference type="WBParaSite" id="DME_0000316401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000316401-mRNA-1"/>
        <property type="gene ID" value="DME_0000316401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000316401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30499" checksum="00D9DE37AC1428C2" modified="2015-12-09" version="1">MSSLKRAAKCGQRLHRERPQPESRAHLGHLERKKDYKKRANDYNRKKAKLLKLRQRALDRNPDEFHFHMIRSRIANDGSHREFNSEADEDTLLQKKLADLNNFKYVKYKLNIENKVKIEKLKSILHFADMTTASQNTHTIFVDDDEIKSFDPVQYFDTTEELIDRTFNRPRLSVLKKEFVNVKSRCEVEEAEKERKLLYKELIKRMQRAKELKIVIEKLETRKNISGNSGPLKPKKVSRGELMKAPVYKWVYERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U827</accession>
    <name>A0A0N4U827_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7332</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U827"/>
    <dbReference type="WBParaSite" id="DME_0000317301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000317301-mRNA-1"/>
        <property type="gene ID" value="DME_0000317301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039504" evidence="1">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000317301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13665" checksum="FC7E02B31F081F31" modified="2015-12-09" version="1">MFVLLVALIFVRRGESGDGVPLTKCLDPNTGAVARPLPLPSACKDKDPTICSAIFAVRSGALADNAVATNAFLVNPNCQNATVLTAAEALCPSSCAVCCLTPEFSCQNCMFLIVQTNLMRRRFLQEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U876</accession>
    <name>A0A0N4U876_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7387</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U876"/>
    <dbReference type="STRING" id="318479.A0A0N4U876"/>
    <dbReference type="WBParaSite" id="DME_0000322801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000322801-mRNA-1"/>
        <property type="gene ID" value="DME_0000322801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF34">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000322801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="63284" checksum="A551526A1C351316" modified="2015-12-09" version="1">MSSLNGTDDDDNDGYSLICCEICFNSFQPKKRPPKILPCGHNFCEQCLFSLCCHQQYYLLDYVNCPTCRAEFNTSTAFNAPTNYDLCRMLENKQKDTNVTVIHVPEAMPNKKNEINQLQSIISRKSRRPSLKKELTCTDCSRKFSDKNTRKMARYCMRCFNKDDCLRLSCLECCVNRHNGHELASINEIEYAHHRLINELKEMKSKIKIAADQFERNIKEIKPNCTTKENGSHMMKCNKQKFLLECQAELNFAIAILENPETTPLPPTVIRKMRQYQLYNNAKLFKMLNLIEAYFLAMSTSNFSLNGHQPDAIVSISYRTAIDSIIAINAVFGFNTYQYRQIKNCIKILSKDGISNDEKKNAFVDCAKSLKSLINDDIPSQSLLLFIDAFLNIFYQLNQLVSKYPKNMNGIKRNDIWKLIQCSYSELFKCAAKHWRCEEPDRVNLIDDLAFLCCLYSDVCDHATITICMIEAARARAASSNLSQNEWQYQETRLQLIDEHLLECRRIQKLQELSSTYSNDRFKRIRHLWRKISSFFRAFINSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8C2</accession>
    <name>A0A0N4U8C2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7443</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8C2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8C2"/>
    <dbReference type="WBParaSite" id="DME_0000328401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000328401-mRNA-1"/>
        <property type="gene ID" value="DME_0000328401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000078">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000044">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041477190" evidence="15">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="248"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000328401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56447" checksum="05E8991721A1B9E8" modified="2015-12-09" version="1">MAILILFYLAVHCFFQMAVKSQLYEDLLYGYNRVPRPVKNSSDALIVHVGASLIRIIDIVKFFNYFILKQWYDAKLTWNPSKYGGIKTLHIPSDLIWIPDFVLYNNAVGDPDITIMTDALVAYDGRIYWRPPAIYKSFCPIDVTWFPYDLQSCEMKFGTWSYTGSDVDLKQLPKEVINGTDKHGQNVEIMEKGMDLSFFYQSAEWDLLSLSSARHSVLYTTCCGPEKYVDITYYFVLRRKTLFFTCNLIIPCFLISLLTTTVFYLSDHKITFSISILVTLTVFFLVLIDIIPPTSLVIPMFGRYLITTMILVSLSTIVSVITLNLRFRSGPESHMPQWIRSIFLNFLPKVLFMSRPKSKNNGDHLKPNHLVDPIALIEKKRWSARLSNGKRFMLSYQFLQFSIEIYAHLFKRAFKSFQFNLRMRKLIIIVEWRFVAMVLDRLFLIIFSILNIGAFLIILEAPSLHDTRKPMNITSATKPLGQASFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8P3</accession>
    <name>A0A0N4U8P3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS294</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8P3"/>
    <dbReference type="STRING" id="318479.A0A0N4U8P3"/>
    <dbReference type="WBParaSite" id="DME_0000342801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000342801-mRNA-1"/>
        <property type="gene ID" value="DME_0000342801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="10"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000342801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58848" checksum="E601DD40F73AC355" modified="2015-12-09" version="1">MLGAFISLVLSYSKRDWSEVESFSPNIFFLVLLPPIIFESGYNLHKGDFFANMFPILTFSIIGTTISAFTIACSLYILGQADLIYPLNFVECFIFGSLISAVDPVATLAIFQALNVEPLLYMLVFGESMLNDAVSIVLTSTALEIVQQPDPFAKTAGETLLAALYRFTYVFIVSALVGAIVGFFSALLFKYIDLRKTPALEFALLLVFAYLPYGLAETISLSGIMAILFCSITMSQYTHFNISPITQITMKQTLRALSFVAETCTFAYLGMALFTITLEFEPMFIFWSILLCIISRAFNVFPLSYLVNKCRETQISKKNQDTVLGLLYNDYFKYFKGMRGAVAFALALHISIEDDLTKRILLTTTLFIVLFTVVFLGGSALPLLKVLDEIFSDQERSKKKRRARRFREKRKIFKSHVLLSKTQEMALLEHSEMTSAAEDGSCIIATRRPSVKSNNFASRFNELFIRPIFVRNFTAQEKFENQMNLRCVTNEFFNEAENEFQFDQSSCDELFSHKSFINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8X5</accession>
    <name>A0A0N4U8X5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7519</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8X5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8X5"/>
    <dbReference type="WBParaSite" id="DME_0000351401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000351401-mRNA-1"/>
        <property type="gene ID" value="DME_0000351401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984255at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000351401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34037" checksum="CC3143189F17303F" modified="2015-12-09" version="1">MDSMKGGPDSSFNDNLIREVRRNPIVYDASHPLYGNALKKQETWGEIAGKLGEKAFLLNRTTIELQWNAACLQLHCTIFGYASFEAVKTRWRTLRDRYTKERRRVTTLGGGSTFSYYSDLSFLDHCTNENRKSHNNLIGTPFKPEFFDQASDGSDDIVSHQGEINRVENQEIAHMDENEASVSNHGISNQRFVQPTIILNDQILEDILPNKRAKVETNSQSTSDSVADALFRSAEALQRIADRRLPGQRLSTSIVRDLRDVRDVDECFADFVCMALKAIDNESRVHARIAILHALAQYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Y8</accession>
    <name>A0A0N4U8Y8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 41 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7533</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Y8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Y8"/>
    <dbReference type="WBParaSite" id="DME_0000352801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000352801-mRNA-1"/>
        <property type="gene ID" value="DME_0000352801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057779">
        <property type="entry name" value="Znf_RING_Vps41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23555">
        <property type="entry name" value="zf-RING_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="666"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="887"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000352801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="952" mass="108933" checksum="DF2D894484C505E3" modified="2016-06-08" version="2">MDERSLKAFETLGTHIKRRSSLGSMASQLEHSTIVSVKSCNTAKIYEEKTDHGFCLMYEGDIKNSKNENYVEFGDCQLDASSSSCDRVEDESDVANGTVIVEPRFKYSRILNNAPMILAKDAASCIAVHDKFIAIGTHSGYIYIMDHLGNLHPESTVRHHVGSVVKISIEKSGGYFVSCGQDARISIYGIGCSDYTQIIELRYAARSVSVSPDFSKRNSIQMFVSAERNLQLHERRFLKTYKSTILFQGLIRDGIIMQTSWHDSFIAFTNNTGTRIYDRSLERIVALIQPARKVPPFDVSRARPSHCWLDNITLAVGWLNNISICSLVDCINQPSSCGLMRKVEMRNIWELDLLIADISYSPSMNSTNWKEIVVFGTKTKQNNANIKEAEVQFVSLEPEVLESFVIITDDRLDMHIDTAQDIYHLHMCALPDESLYFMLSTKDFIMAQLCSADDRVRWYLENSLLREAMEYANQYVFQLKDLDPLDIGKQYIGSLIEKKRFAEAASNLKIVCGKHKDLWEYYVNEFEQNNVLLQIARYLPVRDPQLEPECYQSVLIAALYNHPLLFYKLVKSWSPDIYRAGAIIELAIRRVIHEEQAKNLSEEDIITIYRSLARLHLHERKYEKALILYINLRDKSVFHVIEKYNLFDMVKSNISKLMALDADLTIRLLIENAGSLPTATVLSQISKYPKLQMAYLNRLFERNQGEEFADLAIRLYAEYDHKRLMNFLRKNESFDIAKAMEICERKKYTDELIFLLGRSGDRLKALNLLVHKLDRMESAIAFCRENDDADLWNALIDEATTNSRHITQLLNAAGNYIDPLSVIQKIPSQMSIPNLQNLLIKILRDYESQVQMQQECLSATIADSDSLLLKHLIICASPSEISETSLCSVCKSNIITNDSSSRKVSDDILVFACSHLFHKKCLDQSELQAECWRKSVEDGFCLLCCDRNEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAC1</accession>
    <name>A0A0N4UAC1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS450</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAC1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAC1"/>
    <dbReference type="WBParaSite" id="DME_0000408601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000408601-mRNA-1"/>
        <property type="gene ID" value="DME_0000408601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="41"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="204"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="472"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="571"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="656"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="708"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDN50477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000408601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1175" mass="133474" checksum="A8B7E5D439B253A4" modified="2016-06-08" version="2">MYDDDEEMEEMPFEEEDEEISSEQWQEACWVVISAYFDEKGLVRQQLDSFDEFIQMNVQRIVEDSPPVELQSEKFGFDIRINFFKYPVNFSGKIYLSKPTHWEKDGAPTPMMPNEARLRNLTYSSPLYIDITKTMSREGDEPKDTKYEKVFVGKIPIMLRSSYCMLANMSDRDLTELNECPLDPGGYFVINGSEKVLIAQEKMATNTVYVFAMKDGKYAYKTECRSCLENSSRPTSTLWVNMMARGGGAQGKKTSMGQRIVAILPYIKQEIPIMIVFRALGFVSDHDILEHIIYDFDDPEMMEMVKPSLDEAFVIQEQNVALNFIGARGAKPGVNKEQRMKYAKEILQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHIGNKRLDLAGPLLAFLFRALFRNLLKEVRLTAQKYINKNGDFILDVCVKTSTITRGLAYSLATGNWGDQKKAHQSRAGVSQVLNRLTYTATLSHLRRCNSPIGREGKLAKPRQLHNTQWGMVCPAETPEGQAVGLVKNLALMAYISVGSLPEPILEFLEEWSMENLEEVAPASISDATKIFVNGSWVGIHRDPEQLMSTLKKLRREMDIVVSEVSMVRDIRDREIRIYTDAGRVCRPLLIVEKQKLALKKKHIDQLKDTSINYSWSDLVAGGVVELIDAMEEETIMLAMMPEDLKAGGYCDTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYTTNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFNELPAGINAIVAILSYTGYNQEDSIIMNQSGIDRGLFRSVFYRSYRDEEANLDNANEEIIEKPSKEKCSGMRYCLYDKLDDDGIISPGMRVSGNDVIIGKTIALPDTDDDLDANVKRYTKRDSSTYLRSSETGIVDQVMLTLNTDGNKFVKVRVRSVRVPQIGDKFASRHGQKGTMGIMYRQEDMPFTNEGITPDIIINPHAVPSRMTIGHLIECLQGKLSANKGEIGDATPFNDTVNVQKISNLLQEYGYHLRGNEIMYNGHTGRKLTTQVFLGPTYYQRLKHMVDDKIHSRARGPVQMMNRQPMEGRARDGGLRFGEMERDCQISHGAAQFLRERLFEVSDPYHVYICNNCGLIVVANLRTNSFECKACRNKTQVSALRIPYACKLLFQELMSMSIAPRLMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAJ6</accession>
    <name>A0A0N4UAJ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8061</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UAJ6"/>
    <dbReference type="WBParaSite" id="DME_0000417801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000417801-mRNA-1"/>
        <property type="gene ID" value="DME_0000417801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000417801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30934" checksum="9399CA6F49C06EA8" modified="2015-12-09" version="1">MGETERIAKRDLISKNRKRRHLEKVYESLIKETNMAEEDCLARSVTIAKNYCKIIDTPQKLPAERLLMADNKKRMEIIKETLKEPIIKFAQTFPIYETLDETTLQQLFDGSLWIKINVLLIIHRYDPSEQCLCLPSGCVFKEDHKDFMNDEQYDIICRFLRLAHVFNKIELDNIRLALLTALFTFYPYDIKPPKTEIRKLFSQIRKDIECLHELYTEGPTLTVRSELYGAIAELQINMPYFKKFFNEPSQFYFIVNLLFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB63</accession>
    <name>A0A0N4UB63_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic polyadenylation element-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8309</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with fbf-1.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB63"/>
    <dbReference type="STRING" id="318479.A0A0N4UB63"/>
    <dbReference type="WBParaSite" id="DME_0000442601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000442601-mRNA-1"/>
        <property type="gene ID" value="DME_0000442601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF17">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000442601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50621" checksum="6E1ED6E5B8EF2162" modified="2015-12-09" version="1">MSFGNEFSTNRQFQNNCHNITYHFPSFQESFPNYGTYQFGTPTESINTITNTRSFPSQMDICKITNSNCSQQFSNCTQQMKDLRLLNNNCINDDKATDLSAHRESDYEFHRPYLKLTRFAKENNFCSGRNPGAPSTPEEYLIVDGAHEIYSRKVFVGGLPIDVSEEEISSTFSQFGPVHIDWPRRLESSQKDCSNQLNRSRSMTGYVFLVFENELSVRLLVTTTDGEKGFSFRLYTVSVSFEKMIEDDKRIRKFIIAQIRPWRLCDIEYMPNPDSPLDPRLTVFLGGLPRPTKAGNVYGTVSYVGIDIDPELKYPKGAARVAFSSISSFISAIRDRFFHMPHTDITKRVEIKPYVMEGQMCDECNGSLCSGRYASYFCGDICCLQYYCEICWDRFHYAESVDAKRSSHKAIMRSGNQIQEFMHPPHHKRCYENSSAFCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBT9</accession>
    <name>A0A0N4UBT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8576</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBT9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBT9"/>
    <dbReference type="WBParaSite" id="DME_0000469301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000469301-mRNA-1"/>
        <property type="gene ID" value="DME_0000469301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF10">
        <property type="entry name" value="SHSP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000469301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30200" checksum="ABA51E19DB5441AF" modified="2015-12-09" version="1">MPQFSSHLDRLDRNWRSDPFWRDLYPRWAEPIFKEGIDIKSKITNNSTRFAVDVDAYQFRPEEIQVKTIDDTLLIEGRHEDIRDRDNFTKMYFVRKYQLPNDVEPADISSTIDSTGRLTVEASKRPHRAVTNERIIPIECPSRRGTDSRASRSERTDEYRPSRNMDQKSVELSDYHANEHREYRSESRSDYRSESRLNNIQPETNRYSRTVTRSNGYPKTNSVSSVQIKKIDPTSLRSDSRTESARSVQILKKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBW8</accession>
    <name>A0A0N4UBW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8609</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBW8"/>
    <dbReference type="WBParaSite" id="DME_0000472601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472601-mRNA-1"/>
        <property type="gene ID" value="DME_0000472601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24883" checksum="44E7F8AF7D9B5959" modified="2015-12-09" version="1">MEKEKRFRPIPKNFTKQFCANIHKEITESYIWNEYLENVLLEMAKRDDMNDAFCSEFAVPISSFHSVPFVDVVKKCDFIGIRVEVALDNDYSVYADISKIFFWFARIIKKKSKRHINIEFDSGALNLANSKIFKNSFKAFDSSKLGALRRYLGEMAGYRLLLRFEGMDEKGDECYDFWISIASSDLHYVGTGYFLFFFGVLFSFCVQNKICHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC04</accession>
    <name>A0A0N4UC04_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisome assembly protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8650</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC04"/>
    <dbReference type="STRING" id="318479.A0A0N4UC04"/>
    <dbReference type="WBParaSite" id="DME_0000476701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000476701-mRNA-1"/>
        <property type="gene ID" value="DME_0000476701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000476701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="12040" checksum="A5EFA8565B3AEB7B" modified="2015-12-09" version="1">RFGEIYLVCRIFDVIWRIFIRLFFYISRLLGFGLFFLEFLEYWRTMGPSITAKTDRFIVLSVSGYVFCYFCINRYILEHKKCPVTFLPASIEDLIRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCJ9</accession>
    <name>A0A0N4UCJ9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquinol-cytochrome c reductase complex 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8795</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UCJ9"/>
    <dbReference type="WBParaSite" id="DME_0000499601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000499601-mRNA-1"/>
        <property type="gene ID" value="DME_0000499601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000499601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13177" checksum="BE9F61DAE0E4CE5A" modified="2015-12-09" version="1">MERKTLCAVNRHGLLFHDSYFEPAPEVTEALRRLNLKEPWVFDERKKRLSIAHTMKMHGERLSKDKWTKWEDETWYLKPYLDEIEAEKKAREDSSGIIPGFSLRKKFSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCV9</accession>
    <name>A0A0N4UCV9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8922</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCV9"/>
    <dbReference type="STRING" id="318479.A0A0N4UCV9"/>
    <dbReference type="WBParaSite" id="DME_0000512301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000512301-mRNA-1"/>
        <property type="gene ID" value="DME_0000512301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF44">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000512301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14215" checksum="29D0A8FD0DA1AC2B" modified="2015-12-09" version="1">MVFDISLFIIKRLQLADVNFDKKFCKSVFNKFICDYIKMDGAFVLKMISIHAGVVISMEIADALWENFIDEQEDMDESRKLTINDDSKHFESDILRHKISALVPLMSREKNRPFHRSANNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDA2</accession>
    <name>A0A0N4UDA2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9094</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDA2"/>
    <dbReference type="WBParaSite" id="DME_0000529501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000529501-mRNA-1"/>
        <property type="gene ID" value="DME_0000529501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000529501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3609" checksum="D11533B01AB3A81C" modified="2015-12-09" version="1">MGAVRIFTFELFIKTTPETFLINNGFCYMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDQ4</accession>
    <name>A0A0N4UDQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS581</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDQ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UDQ4"/>
    <dbReference type="WBParaSite" id="DME_0000547501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000547501-mRNA-1"/>
        <property type="gene ID" value="DME_0000547501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="188511at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000547501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37502" checksum="FBDBA79571BC7476" modified="2015-12-09" version="1">MADGNCAFEFVSISTCRDLDESVVISEQFAEGYEKLKIDANQDLFDVRSIYSKGFVEANFSRNLFSDDENNLSLNQCLYFLYPTSGGELQRGTNTIGKLFKTPKASSRRICLSFCSSKPNILIKKVLGNTSITKAFEESPSFSKATYNVTVKILNRLWDEALLDKTSEQFQTLSNDVTRAVSFKNSTKNAYGPEIDYPIIPNNGCGYHNACEFSYDQVNTTNDKKGYDNAAYQTTAHGRQFSQATTASQNGKGSPNTTDESPKGVGETTYQEWFNKVASKAASQQHEEASLPSPVSRVTSSRQSFIAAPYIASDPTGYYNLAVDYHRMPPPGYYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEG6</accession>
    <name>A0A0N4UEG6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9365</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEG6"/>
    <dbReference type="STRING" id="318479.A0A0N4UEG6"/>
    <dbReference type="WBParaSite" id="DME_0000577201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000577201-mRNA-1"/>
        <property type="gene ID" value="DME_0000577201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000577201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20321" checksum="E7621E62F7202705" modified="2015-12-09" version="1">MATTRGIVGDIRIKTKTGETYIAASQRADGSWRKARRVKDGYIPQEEQPIYESRGLQQSRESTYPVGWSPMENTNKVKLAKDYRKQSDPSIKPNIPVSSINRPNAPITPQDHTAKKIRNLYKKLNDIEVLEKKHPFKKKIENGELLKPEKTQLEKISRKEAIEKEIRQLTIELEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEP1</accession>
    <name>A0A0N4UEP1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 87B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9378</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEP1"/>
    <dbReference type="STRING" id="318479.A0A0N4UEP1"/>
    <dbReference type="WBParaSite" id="DME_0000585401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000585401-mRNA-1"/>
        <property type="gene ID" value="DME_0000585401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="7">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000585401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15875" checksum="3EC7AE255CF2858A" modified="2016-06-08" version="2">MVNVVIINFSWVDIAFWHLLFCAILIVIMILWRPSQNNQRYAFTPLLDDSEDENEEDELFSSNFLTAYDVNQRTKSEVRLENEKQKEAEEHDKEIKEDLKWIDVNIPTSVIDKLLLDEDEERTQIELERSKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES9</accession>
    <name>A0A0N4UES9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS840</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES9"/>
    <dbReference type="STRING" id="318479.A0A0N4UES9"/>
    <dbReference type="WBParaSite" id="DME_0000590101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000590101-mRNA-1"/>
        <property type="gene ID" value="DME_0000590101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876869at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF20">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000590101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="974" mass="107403" checksum="FE24EC5E7D8CA28C" modified="2015-12-09" version="1">MEIGTNELTRPFRIPRRKNNPDETNDNADEVKRSRAAVDSDLRSPLVAPTTTRRNANSFSRIVPPTKRKAPGDNHNQSLNAKKSIKQRSSGPEVLDKILGIMVNPPKDRRRDVNSEQYFFAVMKEEIDESDPNEASNPSKSQNAPTLTYEELQKRYVDNSLCYSFLTKEGLMERLLGLKMLTGRIDSHATLGCMSYDPNDPRRKNYGASSNFDNYSPILKEQQLTGQFNNAPMEERKGPRTPPGSPGQADNSSLISSRGVGSASPSSPPPPPPPPDEEPLNKSDPANDIIAEVAEFTKLPPCRLSECLGEELQNAVKQVSLILNVLAVDRSVLLNTLKDALIRVGKKEEPSMKSTRALSVKKEQPIINEGEIIETATVEVEMDIESSKSFEEKEQRVLPPPPPAPKTPPFFLSEVNLIAPLNHPTLATSGIPSIGSCILPTPPPPPPIVSTVVAPPPRLSFCHNPSSINMAAPSSTSSAPILPLFNQRPPVKFKNEVSTSPQASSDVTCFNPSIQNPLFTTPPPPTINTNILLRPSLQASRPPLLINETSLGIPAKPPPNADQFSSIANSKIVPLMPFPPPSETIHSNQSSSSTSKKPQPPTFFNSRIDFSKPPPIHNPPPRNISPVSSSALHFMEKSASNFNNPNSSNLLTQELAPTRFPSVYSLKENRTIIANGKSDIVPSVSTLSFSQAPDPFSLYHLSQRTDQLSSTPSIQTYRRNNDSTFMKNDCSSLQSSVPPENNPTPTSQNVIKTLLSALAIPQQSKSPPSAKNSFVPMNNVSGNTQNPTTINFSIQMDHFNRFSRQNSDCINHSQQIFDGNRQYCGFSSSFNPSVLNERQQQEDDSDVVDFSWPPANFEETSNQQTPTESSVMGNMSNMEQEKRQINYSPGRIQCKAPTNSLTNSIRLNSVPDGGNFMNRKLRPPPHAPFIPLRPSHFALPGQSKPLTFFPPQRSIPSLRQIMPERFVRPPFRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF75</accession>
    <name>A0A0N4UF75_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aryl hydrocarbon receptor nuclear translocator homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1011</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF75"/>
    <dbReference type="STRING" id="318479.A0A0N4UF75"/>
    <dbReference type="WBParaSite" id="DME_0000607201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000607201-mRNA-1"/>
        <property type="gene ID" value="DME_0000607201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000011">
        <property type="entry name" value="Aryl hydrocarbon receptor nuclear translocator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000607201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51869" checksum="5346EA3F44C8139C" modified="2015-12-09" version="1">MTTVGQQTFLDHWPMMQSENIIDESGSMSKYARLDLAENERFARENHSEIERRRRNKMTYYINELAEMVPQCAALGRKPDKLTILRMAVSHMKAIRCGSQNGTEASYKPSFLTDQELKHLILEAANGFLFVLCCETGRVLYIADSIIPVLNMRQEDWLHHTIYELIHPDDIEKVRDQLNGSEANLNRVLDLKTGTVKKDQGSVRVHMSCRRGFICRMRLGPLEPLHRLCNRRPLFTYNGHNYVVVHCTGYVKNSPPVGLDAPQSSCLVAIGRLQVASMPVSPEIASPPQFSLRLAEDGKITFVEQRATSLLSVSTEQLLGRYWWQIAHPADEQTLHDTLVRVMQNQPTQVSVRLRSSNDFYACTVSAHKFLNPYSEQFEYVVATHVLILNNNETWHTTSQVFQAPSQYDQSGAAEWTSATSFNPDGLLPPIRRQNIWQDQWASVDQFGNSSQLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG74</accession>
    <name>A0A0N4UG74_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9588</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG74"/>
    <dbReference type="WBParaSite" id="DME_0000647701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000647701-mRNA-1"/>
        <property type="gene ID" value="DME_0000647701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7118285at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000647701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="15068" checksum="76397C58076A14C0" modified="2015-12-09" version="1">MPRHLTSDAHEWINEIPTVPIYYLAKPQPRERAWRTQRGKKTLLSLTLPPVKYHYFHRFFTYSVRRELSCIHRLLFLAFKYLDTWCWYDSRRRQCQAGSLTGAVHLSKRNAGVLRLAQRGRKPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGG5</accession>
    <name>A0A0N4UGG5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1313</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UGG5"/>
    <dbReference type="WBParaSite" id="DME_0000658401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000658401-mRNA-1"/>
        <property type="gene ID" value="DME_0000658401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000698">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="348"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000658401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="656" mass="76343" checksum="91D4FC56E5B9783B" modified="2015-12-09" version="1">METNEVVITTASNVPAGVLISNIITSSIPVLPSVPNEYSNLSSGGSMSNDRDLESAEKPLVGVKYSKSLERKAPRKRKRLDEQRQERKITECFRVCFFSYRSINILQNFILGFLKEYQFHYRMELAKKDVLIEELQRTIDDLKQQAIRKDRRVEACKETIKRLLIEQNTMERKQAKAKCMEDCLRIGQFKPTRHREEFREMWSDGWAFEEIEKAQQKITNERNEIVNASQNLRKRKPANSLREIKRASSSSNDGFLPSTSTASGSCSLTSDDTFARPELPKELSFQEYIEQDEIYRLRKEHLKKEESELIAEKDRLERERNLHIRELKRVQYEEASRYKDHELLNKRYLLLSLLGKGGFSEVWRAFDLDENKTVACKIHHVNKEWKEDKKANYVKHAMREKDIHKTLDHPRIVRLFDLFTIDNHSFCTVLEYCDGNDLDFYLKQNKQIPEKEARSIIMQVVSALRYLAEKRPPIIHYDLKPANILLQSGTTSGAIKITDFGLSKVMDDADEGDSIELTSQGAGTYWYLPPETFVVGCNPPKISSKVDVWSVGVIFYQCLYGRRPFGHEQTQQKILEENTILKATEVNFPAKPTVSMAAQDFIRRCLQYRKEERADVFELSRHELFRPRGQVIFIFAYLNPPSSPSAKNTRFEDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH04</accession>
    <name>A0A0N4UH04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Large neutral amino acids transporter small subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1410</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH04"/>
    <dbReference type="STRING" id="318479.A0A0N4UH04"/>
    <dbReference type="WBParaSite" id="DME_0000679601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000679601-mRNA-1"/>
        <property type="gene ID" value="DME_0000679601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000679601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52597" checksum="E0DB514A22FA3F02" modified="2015-12-09" version="1">MKVMREEEEPVYQSPTKDSTEQVGLKPTIGLFGGVMIIVGCIIGSGIFISPKGVHENAGSVGWSLVIWVICGAFSAIGAYCYAELGTFIKSSGGDYAYVMAAFGPMMGFLRMWIECIIVRPCTITAVAITFATYILQPTFRHCGMPNLTPQFLAAGCITLLALVNCLSVKFVSFIQNFFTIAKLAALVLIISTGIVLLIMGDPYRDSFENLWEGSNFDPGNIALAFYSGLWAYNGWNYLNFITEELIDPLKNLPRAIAISCSICTIIYTLTNIAFYAGTTLEELLESNAIAVDFADKYYGVVAWIMPVLVAASCFGTVNGVMLTTSRLFFVAGRHKHMPWVLSFINPYFNTPIPAVLFTAVFSMAYLLLSDNIYTLINYVQIVNWLAIGIAIAGLFYLRIKQPPRKYPRPLKVNLTWPIIFFAGCVFLVVFPVYQAPVDTAIGIGIMLTGIPAYMIFVYWSRKLGFVNEFMGIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH46</accession>
    <name>A0A0N4UH46_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1462</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH46"/>
    <dbReference type="STRING" id="318479.A0A0N4UH46"/>
    <dbReference type="WBParaSite" id="DME_0000684801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000684801-mRNA-1"/>
        <property type="gene ID" value="DME_0000684801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000684801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42314" checksum="1158A3DA8039E669" modified="2015-12-09" version="1">MFQPRFDRTRTTWLETNSNFLYQCFFVVWLCCFFIKFSGASLVDNKLKLNIVPRTGVVALAAPTFNYGHIDRAKARTKERIRTRYPDLAKRFHRIGLPLKTGSFQLFVKGYKDASYWLRQWELHPEQQPPPVTRKQLQLEFEKLVVLDYIIRNTDRGNDNWLIKYEPADTHIPQKLNPSVQQVCYGLYNYYHITSFSAHKIDVTDDENWNHVSMPTIKIAAIDNGLAFPIKHPDEWRTYPYRWAWLPMAKEPFSEEIVDLVLPFLDNVNCVKELCNDLKKLFKEDLGFDKKIFELQLSVMRGQIFNLCEALKQRKSPLQLVQVISEAASASSSGASEMPKSWFETYQQKVQTRSAFFTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHE9</accession>
    <name>A0A0N4UHE9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1555</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHE9"/>
    <dbReference type="WBParaSite" id="DME_0000697601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000697601-mRNA-1"/>
        <property type="gene ID" value="DME_0000697601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842775at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000697601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16478" checksum="25F91746C3234830" modified="2015-12-09" version="1">MTDKKGKKKKTVLSTTSPSHLAEKSKAPQDSVTTNWLPERISSKQFTYKGPLVIRAKQDSTVRHELESEDPSSLESGHVTFDDALNEAYEVGTGVEIRLNNENQDKERNKIVQKTEQKVNQRRKSISSKAILLDHYGSAGTFIHAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI32</accession>
    <name>A0A0N4UI32_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9913</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI32"/>
    <dbReference type="STRING" id="318479.A0A0N4UI32"/>
    <dbReference type="WBParaSite" id="DME_0000724501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000724501-mRNA-1"/>
        <property type="gene ID" value="DME_0000724501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="51"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="224"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="407"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="581"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="790"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="968"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000724501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1183" mass="137139" checksum="A05FEDAAA33120FF" modified="2015-12-09" version="1">MRNLTVWKSSCTKLDLKCDEFSDISFNNAQAFLIDDFGQIYCAFSQGILQFPSQTVEVFRLDSQHIIDAISWAPDHHLLISISSDLLHFFSRDFQCSGIKSLISSEIGRDQLVSLGWGSSETQFQGAGRRKQQENEYETEVLEHDIGNTLISWSGDATYFAVSYVNSLKIRKVSIWNDEMDLISCLEPLSGIEQSLAYRYFFFSSAISVILLHFFSELFLAPPFRPSGNLIAVSRVKGIVREIFFFERNGQVRSSFKLPDVNNDYVSWLGWNYDSTIFCIHLATLNCTLREGFFFSIFVFKIIFVAYFEGLQFFIRRKIHLKTYNLCETCAFLFLNNFTIFVITVQFWCVSNYDWMLKYRITFSNHLLYSRWANSSPNVFKYVTNEGFVWSIEFSFIYNIHDGIVLVINGQNVRVTDLTSGVVPPPMCHYSMEFPDTVSAIAQCGAGAAFFLTNHFFHIYDLIERKYFFKLSKHFDVSFAAPFLCTNISFTGQHIAVLLISCDNHSIIESTVDNLDDCSVSYSSAVPISWLHSENSNVFIQSRSREIFLLQYRQLNLLSQPTEGVNDEILYKRNIETIYLRSLLINLLKKLIDSLKYVECIHLMKRHRIDMNLLYDHNPELFVQNIEFFIRSVNNSDLINLFLLALNDDDVTKGMYADCYSISENRNGLEKKNKVNFISESFRKCLEKFDEKELIRLYTVVLSTYLNVTPPQVTRALQDLQKRSGFDEKNLKKSWIEYVGLLVPSENLFREALGVYDLSLALDIAHITSQDPKEYLALLSYFQSVTPEYYQNYRIDLYLNRYDKALENIAKVDEKFDEAVQFIINHKLYSKALVVFQDQTSFHKICYIYADYLMKKGSFKEAAILFRREGSLKIALSCMEKCYDYNGYVELCVELGISGEQCSSSLIRMVQHFKNVGRFHDAANVLCLMHDEAKDLQILELYCQANSWNEAAKIARKIHQPDSLILLKKMVYNRYSQLNDFITKSTDDMKRYINRLNIVRQKKKEAIENAIIYDYENEELLSDISTVVSHISKSSMNTLVRRKKKMERKKTTLKEGSSYEDAALLNALKSLINNIDTIQDELAPLLVLMFDIDLLAEARDLQQKYTELLLFANKSIATVWPCHISLHLLTGPWQELYRTEDGIIRVPNEIRMPNRIALSSELIAPHIRENVSWRLQFLQSSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIC7</accession>
    <name>A0A0N4UIC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransf_21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9988</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIC7"/>
    <dbReference type="STRING" id="318479.A0A0N4UIC7"/>
    <dbReference type="WBParaSite" id="DME_0000735201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000735201-mRNA-1"/>
        <property type="gene ID" value="DME_0000735201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867391at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF4">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="62"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000735201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30477" checksum="E74CEB2083699C54" modified="2015-12-09" version="1">MTDVVENFSSCPRWFEMMITLKKCYLTKLSTVRQPWYLIANISVECGADFVKNLLPLKYLVNKDDVKAIVLPFNAKTEGISLTIGIGNDIAVEMRLKKLMPNLKFFGVDPLHEDGILFEQLGQYRKIGISEKGGSLNASVLENGLYVWRIIESITMNELLHDFKLSEVDFLFLDIEGVEYTALPSILSSEMTKGIFCQINVELHGPLMDYGATMKDFFRILKTIFMSSSSYIPLWIPLPTMHHRIFLVNWRHPYCLKKYFSYWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UII1</accession>
    <name>A0A0N4UII1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10052</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UII1"/>
    <dbReference type="STRING" id="318479.A0A0N4UII1"/>
    <dbReference type="WBParaSite" id="DME_0000741401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000741401-mRNA-1"/>
        <property type="gene ID" value="DME_0000741401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000741401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50607" checksum="F5963760C532D264" modified="2016-06-08" version="2">MREILQVQAGQCGNQIGTKFWEVISDEHGIQPDGSYAGESDLQLERLSVYYTEASGGRYVPRTVLVDLEPGTMDSVRNSPYGKLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDNVLDVVRKEAENCDCLQGFQLTHSLGGGTGSGMGTLLVSKIREEFPDRIMSSFSIVPSPKVSDVVLEPYNATLSIHQLVENTDETFCIDNEALYDICFRTLKLTNPNYGDLNHLVSMTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFIPGFAPLYARGAAAYHASNVGELTQQVFDAKNMMTACDPRHGRYLTVAVIFRGLMSMREVDNHMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQEVFIRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEASVEDTDEYDQEDAMRNDMIDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIL2</accession>
    <name>A0A0N4UIL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Importin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10016</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIL2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIL2"/>
    <dbReference type="WBParaSite" id="DME_0000744701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000744701-mRNA-1"/>
        <property type="gene ID" value="DME_0000744701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="10">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="10">
        <location>
            <begin position="181"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="9">
        <location>
            <begin position="514"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000744701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128780" checksum="1AB3C2332E32B6BD" modified="2015-12-09" version="1">MATEMQEFRYLISHMLSPENDARNEAEKRYDQIPKATQGRLLFELFLDNSAEFEMRSMCLILLRRLLSKDWDEVWPIWGEENQKGFCEQLLKLATEETHSVLRKRLCDVIAEVARASIDNESGRQKWQGVLRFLEICTTSSSATLQETGMMLIEMGIVDYSTVIIGGLVKRFFLCENQAYFRNEPSVFGCDRNHYITGIKQMFQTSLLYESESSVRTAAVRAYVAFLTENEDDDRLIKSLSDQIPAVIKVCSHVVEAETDDDVPLQCLGDLASNVPRVIQPYIIDIFNLCCATVANKEKDDSYRHSALEVMVSVCESAPTMLDDDVTEWLSKDNTDEDDDDDQNYGFGESSLDRISCSLGGKAVLQPFLGIISRLIHDADNWKNRHAAIMGLSTVGEGCKRQMEPMIVDIVDNILPFINDPHPRVRYAVCNALGQMSSDFEPTLQKKCSDKIVDGLCSLLVDLSCPRVSAHAGAALVNFSEDCPKIVMAAHLRKIMEKLEFVLEHTFKQLEFLNVEFKLLERGKKLVLEQVITTIASVADAAEEYFITFYDRLMPPLKYILQDAKSDELKSLRGKTIECISLIGLAVGKNKFTKDAHEIMQILLSDQSQFQNLSCDDPQTSYMISAWARICKILGESFAEYLPVVMPSVLHTASIKPDVALMTEDEATVQEDDPGWSFVPLGDQKLFGVKTAGLEEKSTACEMLVCYARELKGAFNPYVESVVDLMLPHLKFLFSDEVRSAAAEIFPHLLACVRGRGEAYRSGLWRAVLPAYKEAIDSEHDRDVLADQIEGIAEVGFTIFILSENSPALIAICITELGGNMITNDDVRLIVDILLQQLKVIAENVHRRDTGEKEDEDDAGETDNEAIEEDANVLSRITDVVHALFKEFRQGFVPYFEQLEPIFRPWLSQKRHFSERQWTICMYDDLIEFGGEASVQYQQYFYEPLISCINDEYPEVRQAAAYGIGLMGLYGGKAYAQLCAGALQPIANMISDQAARSTTDALLATENAISAVAKILKFNSSMIDVNAVIPTFVQWLPVWEDTEESPYTYDYFADLIESNNPLVLGENNSNLPRILSVMVEALDKCALDSDESDEIELKQRRETVKSRLINIIKFMQTNAEMFQAIVVSAALNEQQLSVLQQVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK38</accession>
    <name>A0A0N4UK38_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2187</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK38"/>
    <dbReference type="STRING" id="318479.A0A0N4UK38"/>
    <dbReference type="WBParaSite" id="DME_0000806201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000806201-mRNA-1"/>
        <property type="gene ID" value="DME_0000806201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="256"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000806201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79978" checksum="509FAF655886108B" modified="2015-12-09" version="1">MDKMKEGLQRRARRMQENLQQSVGLSEKKDELQCINHIEQRNQKLVSAVKNTKQNLQTCIRNINKEETIEKRKRRLDEFGLWQQLQVDARELENVFCRQESSLLCDILRLYADVIGSILEEKVLTDQVIEKSVIDAFGKYIEEEKSISKAKDKLARTVVDVEVSRKRKNGNHDEAKAQEIQDEYDALQLKLDNYKDNIFTDIYNLCSKETEIATIYQNLIVAQLNYHRAVVHKLESILPEVDRKIASYRRRPVFGIHLDDHLCSSNRSIAIVLEVCCSALVRHGFNEKGLFRVNGNNNRIRRMKAAFDAHEICASTNELSEYVSDPHSICSVLKCYLRELPEPLLTRELHTEWVRVARLEQESRKDSISELLTDLPESNRLNLAYLIRFLQYMLDFEEYTKMGVSNLSIVFGPNLIDSRSANSDNMLGSKIVESLILNADYFFPNDKFSFNSSLTDSFNQRLIDSTGGFEMERTPPRSTQLQIDPFITYNNSAPEVSPQPSVASSPQGQSYRSRPKLPAPPPPSCANNVANIFNDHIEEMCTSLEQLNTITRKSPSIASNDSMAEYGCINNEISEDYDCISMTRSINENNLAKPLRPPPPRNTRRTSSSPDQISQIFIRPTSYINAVCIQDFTELPKRESSVSFSNTEDNRKIIRLESEAFQRSPSLITTIANVPMPKPPLPMKPKPIIDLKPDEVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK48</accession>
    <name>A0A0N4UK48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ral GTPase-activating protein subunit beta (Trinotate prediction)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK48"/>
    <dbReference type="STRING" id="318479.A0A0N4UK48"/>
    <dbReference type="WBParaSite" id="DME_0000807501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000807501-mRNA-1"/>
        <property type="gene ID" value="DME_0000807501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000807501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13909" checksum="C4D3AB877143054A" modified="2015-12-09" version="1">MYEEWPVLDLCDVKEESSLSFISKEASNCIAEILIRDIINVIDNREKVENFCLRIKTDEELSWIMQVITHSLSFSYFSNKECDTVHNAVRIYTTWLCAAATDLNIIVPLTLKRDPVKYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKH1</accession>
    <name>A0A0N4UKH1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Segment polarity protein dishevelled-like protein DVL-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2288</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKH1"/>
    <dbReference type="STRING" id="318479.A0A0N4UKH1"/>
    <dbReference type="WBParaSite" id="DME_0000821201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000821201-mRNA-1"/>
        <property type="gene ID" value="DME_0000821201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000203">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF24">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG MIG-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="12">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="252"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="11">
        <location>
            <begin position="468"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000821201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="740" mass="82198" checksum="BD02CFCA9C2E3D75" modified="2016-06-08" version="2">MVLSSTTESTKVYYYLDDNTPYLSVIPVSDQLITLGDFKKVFAKKGYKYFCKQLDETIGCEVKVEICDDATKLEKSANGLIELVLMSIDANHAFAGTLPRIGNMKAQREFQTTSCSSRDYMMKKRRSLYDLSSEKTVGNDSSMNHFHAYISKSTENSVTASSLSTVISKRAGERLADHYTSNSEDRIDSRFSVNSGACSSSYGAVKQNVLHHKAYRRRKPRKQRYRRTYVPSTISSVSESSITSLSLPRIDVVTLPMKSGTFLGISVLSHDGGIFVSDIIKGGAVALDGRIEVGDQIIQVNRSSFENLTDLQAVQLLRQAAASKKPITLYLAKRPCNTDSRHDVFSGLASETMPIDVSLWVECTKQSNVKPVRPFAVDETVSTKDDEVFPLGNETETDVEGAYIERRNGISLKNKDIAPQDVQANLLNAEDVDRRRENEENEDFAEQLIDSLNVSMDPSIILKQMTRIDSGLQIKNRKWLKIPVPMSFIGCDLVDWLIDHVEGIKDRKSARIYASKLLSEGYIRHVVNKLTFTEKCYYIFDVASSLDVLMTKYDTMMVGGIGKLQREESILSTKIGVQTGSNCKTGPEATTEITYVGSPTSQIPRFGLRNSNNLGNFTYTKKNITLDEPWPLSALSNGSSFKRKDCDSFMVNDYASVIAPDIIASTMPSSVGEIPYLKRPYAVSSVLTNPRLIDDDIRGMQPPNTPNSVIDQSNRGSAASETEFEVIDDEGRNIACATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL85</accession>
    <name>A0A0N4UL85_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2503</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000064">
        <property type="protein sequence ID" value="VDN52530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL85"/>
    <dbReference type="WBParaSite" id="DME_0000854701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000854701-mRNA-1"/>
        <property type="gene ID" value="DME_0000854701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772860at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000854701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19390" checksum="2B5DAFD9B028093B" modified="2015-12-09" version="1">MNFYSISFIWQVLSEFLYATHIERFSTVTCQTHIPMEGELYDEGLDAKLPRGWYRIGPQQIRHDSSWLNLYRRRATGSGYWDFYTNIPERNCIGGFGLHAGENIAGSITVKDKRCFDRLLRQIERKTTGEKFDVLQCRKCIFNSCWLGTKLLPAYRQYLTNLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULB5</accession>
    <name>A0A0N4ULB5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10430</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001217">
        <property type="protein sequence ID" value="VDN60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULB5"/>
    <dbReference type="WBParaSite" id="DME_0000858301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000858301-mRNA-1"/>
        <property type="gene ID" value="DME_0000858301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858611at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058390">
        <property type="entry name" value="DUF8077"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26284">
        <property type="entry name" value="DUF8077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8077" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000858301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21155" checksum="F3B61B80AE88E7C2" modified="2015-12-09" version="1">ELALLDWSSGIRFAYCADVTIEKLTEPFKASLIKAINKFCSNATACLLKSPVIFAVEQIVLLDGYPRRDYGAVQFRFVVVLPHNAVPLIRLRQPLLSNRILSTDILQRYAPEISRRLGWHLMSYEKFPRFDAITEFMNIALIPIGFILLIAMFMLAYWSNNFRFSGSSDEILVSGSSGGKNLALKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULE5</accession>
    <name>A0A0N4ULE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2532</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULE5"/>
    <dbReference type="STRING" id="318479.A0A0N4ULE5"/>
    <dbReference type="WBParaSite" id="DME_0000861701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000861701-mRNA-1"/>
        <property type="gene ID" value="DME_0000861701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF5">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000861701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24134" checksum="A7529176732B9218" modified="2015-12-09" version="1">MLLTYVEVPTERRVKRWGLSVNELVRDPIGRQVLETFLESEFSSENIRFWMAIQDLKFSADKQVDGKSQHIYEEFLASGAPCQVNVDSRTLESTLKLLNDDKTPRRHAFSPAEEHVFTLMSKDSYPRFVRSQIYKGVLSAAQQQGSKRLGWRNFVFNVGNQKKTPLTTKHKMSRDDNSHSSLPKQLSSDSLPIKTQAQRLVEASSIGATTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULW4</accession>
    <name>A0A0N4ULW4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ODV-E66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2686</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULW4"/>
    <dbReference type="WBParaSite" id="DME_0000881001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000881001-mRNA-1"/>
        <property type="gene ID" value="DME_0000881001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF95">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000881001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29520" checksum="6F44BB39B2697A8D" modified="2015-12-09" version="1">MESRPLLIKVLEKSFNCNARLVAEYPILTIVICVLFTIISTSIIPFKKIKDDFKIGYTPSDARSLKEMESYSNFSNGDLIALMVYVTAKDGGNMLRIEHLNATVDLIDNIGSNFKIKNSSFYEFCDNFCNANEPVAVFRARRKKLKNLLINCDELKKKITTANGLIIQQNNLLDSGYIDNDRINLSYPFMSFFGRSIDLTMNFHGVELIKNMDNVVDVITNLKSLKLIFLMFRASKPHNWTDDDIAEWDHNVADFCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULX4</accession>
    <name>A0A0N4ULX4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2697</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULX4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULX4"/>
    <dbReference type="WBParaSite" id="DME_0000882101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000882101-mRNA-1"/>
        <property type="gene ID" value="DME_0000882101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF5">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE UGT-58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000882101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55637" checksum="3F021B969353625C" modified="2015-12-09" version="1">MSHIADELVKRKHSVTWLEFGYEKSNFELNHGVNEIFWYVNRRGSKQDNRFYRNISIDELVWRTDFMNDAEKISAWLTSIEICDRILSHRKSEFDELVIQKFDVVIVDDLYNPCGLLLVGLKKSTFIYWSLTSFRTETAWANQSPFPPSYLPVPGTGLTDDMNMLERIYNLAAYWRTIYVHHHIILPRVDVIFQKYYPESVPNAFFIERNASINFINTPLVFDFARPYMPRVIFVGAIHCREPQSLEGALSEFVDGADDANGVVLFTSGFSIEWKRAPANIINAFVNAFRIMNATRFVWQYNGWPIKNLPKNVLILDWVPQQDLLEKMFFLGHPKVKAHITHGGLNSVIESVWHGVPIIGIPFTISAYDNIIRLTSRAVGILLSKKDLRVELIIKALKQIRHPRYMKEMNVFRDMVVDVPYTELNHSTFWVEFIERHQEVPHARSGADELNILQYFLVDVVQLKICLSKEALIKKKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM50</accession>
    <name>A0A0N4UM50_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2750</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM50"/>
    <dbReference type="STRING" id="318479.A0A0N4UM50"/>
    <dbReference type="WBParaSite" id="DME_0000890401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000890401-mRNA-1"/>
        <property type="gene ID" value="DME_0000890401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000890401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26036" checksum="F6B99B202D350D1D" modified="2015-12-09" version="1">MGVVRHSAIEKEQHLKLFRNNLQMLCNYDWVPIPLAYPQLVFLAVYVYFAICLISRQFIVNKEAASKTSDVDLTLPFVTMMEFLIFVGWMKVAEGLLNPFGEDDDDFECNFLLDKNLAATLYDIFQTALCIVDEASNDAPELAKDQFWSTKEIEPIYSKESAAETINPLVGSATLSNISGEVDQGTRMVVRKSIDISNGTSSIQHSPSGRTSRKWRLGSIVDRFGSMRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNI7</accession>
    <name>A0A0N4UNI7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3169</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000110">
        <property type="protein sequence ID" value="VDN53196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNI7"/>
    <dbReference type="WBParaSite" id="DME_0000946901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000946901-mRNA-1"/>
        <property type="gene ID" value="DME_0000946901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000946901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10190" checksum="81EBFF7FC38E7968" modified="2015-12-09" version="1">MAYINVEFQIPLQNRMFVERPCGENMVHTELCYYDVTYNFITNCRKISNCVCMNGYYLENGSCLELPTTTMDPEKAANLQRLAMRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPI6</accession>
    <name>A0A0N4UPI6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3453</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000135">
        <property type="protein sequence ID" value="VDN53480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPI6"/>
    <dbReference type="WBParaSite" id="DME_0000987601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000987601-mRNA-1"/>
        <property type="gene ID" value="DME_0000987601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778723at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039251" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000987601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9388" checksum="B7B11AFFA7847CFE" modified="2015-12-09" version="1">MNSCTLLLIASVTMFTSCESFWWNNRNYIRFRKPDDVWQPPFRTIMCGSFPLKVRLDADVEEVCKGYLERLRTIGELYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPQ3</accession>
    <name>A0A0N4UPQ3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS3501</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="UYYG01000141">
        <property type="protein sequence ID" value="VDN53528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPQ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UPQ3"/>
    <dbReference type="WBParaSite" id="DME_0000995001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995001-mRNA-1"/>
        <property type="gene ID" value="DME_0000995001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23459">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="451"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN53528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66718" checksum="AD7E5DEE0D31BDFF" modified="2015-12-09" version="1">MFSFPRYLIPRRRENILNIILFAILLSFFIFIRLNDDVKYKMPQHSGITWPPPYTIVMDHIIPDYDKKRNGPGENGAAVRLNRREAIRGKADMKKWFMNVVASDKISLDRNIPDARNPACFTVSYGNDLPHATVVIIFTDEAWSPLLRTVHSVINRSPLKFLDEVLLVDDFSQRDELHEKLDDYIKRFGKLVRLIRLKERHGLIRAKLEGAKAAKSEVIVFLDSHCEANHGWLEPLLLRLKEKRSAVICPIIDYISAENMQYIVSEPDGVGGFWWSLHFRWDILSKTEINRRKTAIEPIRSPTMAGGLLAANRQYFLDIGGYDPGMDIWGAENLEISFRVIPCIPVWMCGGTIEFIPCSHVGHIFRAGHPYNMTGRDGNKDVHGINSKRLAEVWMDDYKRLFYYHRLDLVKKDAGDLSERKALRQQLKCKSFKWYLNNVAPDKFILDEDVAAFGAVKNPKYDVCLDTLQKDEKNPINLGLFSCQSGGSSAQLFSLTNDGRLRRESSCAKAVRHREDGPGIVRMVDCAGSNLKWVYLNGSLKHLGSELCLDAAGLNYNDDVLVRECLNQGSQIWQFVNFYPHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPU2</accession>
    <name>A0A0N4UPU2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3535</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000145">
        <property type="protein sequence ID" value="VDN53562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPU2"/>
    <dbReference type="STRING" id="318479.A0A0N4UPU2"/>
    <dbReference type="WBParaSite" id="DME_0000999501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000999501-mRNA-1"/>
        <property type="gene ID" value="DME_0000999501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF4">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000999501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31816" checksum="2EB1B6A3BA1F9656" modified="2015-12-09" version="1">METWRETFVERIRIENTIIRECLAEFIGTFFFVFIGTSANVQFTLNDGDKTSAQIAWGIGFAFAIYLATTASGGHINPAISLTALMFGDISLLQFLLYLPVQFIGAFIGAAFAYLTHLDNIASYLRRHNDDEITIAGLFTTFPAAQMSYFGSIIDQIVGTIILSGMIYLITDRRQRISKSIQPILIGGVMSMIAMTFGANCGFAINPARDFGPRVFLLIIGYGWQLFSYRYYYFWIPVVAPLIGAPIGAILYKIFVGIHGLDEQLDITGGPPYPRNDDKEYRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQK0</accession>
    <name>A0A0N4UQK0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3787</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000187">
        <property type="protein sequence ID" value="VDN53814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQK0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQK0"/>
    <dbReference type="WBParaSite" id="DME_0001029101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001029101-mRNA-1"/>
        <property type="gene ID" value="DME_0001029101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001029101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33776" checksum="8CABF8AEF74183D7" modified="2015-12-09" version="1">MNGRWWRQPENFSKDVGKPEKSCSKSCCSNIEEFFDCTDETSIILDRKKAAPLYVVPRTVEKKLYKFVKGKNGDLFADYLLFEDSMKRAKVSWDDYSALTAEERDIYMAHLKAVKDRKLTYKDPKTGYIVMTVSVLLSRRCCGNGCRHCPKRLFRYEMSRHRTRPPYPGIIRRTRLVVVDNSALGKEANLSGKLAYCIHVCKRGYRKKHMPPAALGDKVLVAIRGEIKMAIIVGANVHYGHRKHGVPSTDSNNIILLNDDGNPMGNRILAPISSKLLVKRDKMQYNKVLSLATKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR90</accession>
    <name>A0A0N4UR90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10931</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001280">
        <property type="protein sequence ID" value="VDN60958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR90"/>
    <dbReference type="WBParaSite" id="DME_0001056301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001056301-mRNA-1"/>
        <property type="gene ID" value="DME_0001056301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="234"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="430"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="524"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001056301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66097" checksum="F82F8C18B8EEFFB5" modified="2015-12-09" version="1">MIVIMETVRMVKKLLIMVADEHCGINMRFVEVFKTILLQYSFPVYQCRQREIQPSNSSESFSSNDKICWLRCQCENESYIREGEKCVEIQQRTAIANNPTTIGEIPVLLQFASGENKCQHGDCIYGEEIADFGCRKTNQKCGINMIFEEIRKTLLLDHSEPFYQCKQRCICAKNYFAVNSRKCIKEEFLKYQKTTKEYNSSTNYSTAIHSISTQSDKILNETLHGQSFLCSKLLGQRCGINMIFKEIQLSSFSERFATNGEICWLRCECENESYIRKKDKCIEIQQQTTATNDPTTIGIEKYLGRSHSIGGGRSYKVGDKMFDYGCRKTFAKCGTNMIFKTVSKILFSEFTFSFYRCYQRCSCINGKYFESDGQCMERENLFIDGSRGKTQTTISSHIINSAKNNVKPVSNKIANGASSYDKSVCLMMQGRKCGIHMIFREIQPSSSSESFSSNDKICWLRCQCENESYIREGEKCVEIQQRIAIANKSTTVGETTIRYHLISDATNYKIGDKITDYGCQKTNKKCGTNLVFKTASKIFLNEYALPFYKCIQRCSCINSKFIANDGECSDSLSKTEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URR9</accession>
    <name>A0A0N4URR9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4153</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000335">
        <property type="protein sequence ID" value="VDN54180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URR9"/>
    <dbReference type="STRING" id="318479.A0A0N4URR9"/>
    <dbReference type="WBParaSite" id="DME_0001075101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001075101-mRNA-1"/>
        <property type="gene ID" value="DME_0001075101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000099">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001075101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16286" checksum="DE28B3B42C9DC499" modified="2015-12-09" version="1">MNNIDDIPCSKIRLNLSAKNLYDSDVFSKSDPMCVVYLARDAKCDGNYHEIARTETIRNCLNPEWCKPIFVDYYFEEVQRVKFEIYDIDNTSCLLSEHDYLGKAESTLAEIVGAPSSSRILPLIGPKSGRKNGEIKVIAEEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US14</accession>
    <name>A0A0N4US14_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4243</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000460">
        <property type="protein sequence ID" value="VDN54270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US14"/>
    <dbReference type="WBParaSite" id="DME_0001084601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001084601-mRNA-1"/>
        <property type="gene ID" value="DME_0001084601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819225at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230050" evidence="2">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001084601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20200" checksum="514EA56022B3BA1A" modified="2015-12-09" version="1">MFAVIISLLLLPLTSAGNVDIEECVKLVGNPAKKRPTVDSCPEDPVCSSIFVYHQAAPNDLVNNLMEDQDYKIPELCNKVKDFAARMCPKTCAMCCKTKEFNCHDVSPDACRRLDRNICLTAPSVALSMCPFTCGLCHRPGAAGMCPDENENCAAIFYLDPTCSTDFMKRSCKKTCRLTDCLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USD3</accession>
    <name>A0A0N4USD3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4357</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000976">
        <property type="protein sequence ID" value="VDN54384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USD3"/>
    <dbReference type="WBParaSite" id="DME_0001096501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001096501-mRNA-1"/>
        <property type="gene ID" value="DME_0001096501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5832750at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001096501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="5733" checksum="0F42C29CF67917E4" modified="2015-12-09" version="1">MIQYSNLATTGAAGSSSCTDIRANCAQMSSYCNVPPYSTVMSQQCRRTCRLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2J5</accession>
    <name>A0A158Q2J5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="16">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS4611</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="16"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2J5"/>
    <dbReference type="STRING" id="318479.A0A158Q2J5"/>
    <dbReference type="WBParaSite" id="DME_0000025101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000025101-mRNA-1"/>
        <property type="gene ID" value="DME_0000025101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0186">Copper</keyword>
    <keyword evidence="16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="16" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1003"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="19">
        <location>
            <begin position="217"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="18">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN54638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000025101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126910" checksum="EE293EA0643D38C1" modified="2016-06-08" version="1">MIIGRVRWPLLAHGGLLARGGLLARGGLLARGGLLARGGLLAHGGLLAHGGLLARGGLLARSGLLLSDLLKLTNCAEKRIVLCSLYLGNGSLEKNLVTIGLLLLVDEVEKALDNHPALRVDILLDYLRGTRGGLKNSSISLLKKLYFIQEFGGFCEFFNSLGIGFCNYLFGGGADGYTEDVWCNVVFRGRLSMVGLLVSFLVWLIRVRVHWNYVSSSLEVVVWFERTNHKDIGSIYLIFGFWSGIVGAGLSILIRAELCKPGFFFGRGQLYNAVITSHAIMIIFFMVMPSLIGGFGNWMVPLMLGAPDMSFPRLNNGFSFFRTFVFVCLNCVCYCFSFDFDFICFGWGYYYVVICCNVVLMDRRFNTSFFDSSSGGNPLTYQYLFWFFGHPEVYILILPAFGIVSQSTHHMYTVGMDLDSRAYFSAATMVIAVPTGVKVFSGFTGVILSNSSLDVVLHDTYYVVSHFHYVLRIGAVFGIFCGISLWWTFLTGYVYGNKIFMSVVFFVIFVGANLTFFPLHFAGLHGFPRKLTPRASVHLFHTPYLRGLLKKYLPERSNEIIGLQHMKLYIFDNNIIISGANLSESYFTNRQDRYILVEDCDSLADFFDRLVGAISSCSFAVKSDGSIHYDSDSVEHPYNGKIDEYIGSVCKKIGSLINDFSHSKPSVSHAKFDTFLYPIIQMGIFSINQEYQFLEKLFSCQDESFQLTMSSGYFNLIDKYEYLISRRGRFNMDIIFASPQANGFYQGQGISGYIPALYVDISRNFLGKCPSRVVLHEYSRSGWSYHAKGLWINSSTFFSTLVGSSNYGYRSVHRDLEAQLLIVTNNNDLKKRLIKERNQYMEYSIRVEPSIFLRADHNVPLWMVLVQGLLLGRVLLNVMNRQEGRNVVITSSIPSLSRVSQKRQKARRLVRNVRNVQSNPYEQEEFLNRIGGTSIRNLSEKNVHSLQHLVNDEETWHPVYRFSGIRFGALLARTKLIQTLGSICLMPYIFWQYNNEAISLESFLGVSVLAFSATVLLILYSQYFNRLIGVISMTESNKFIRIGYLSFWGSRRNKIMELDDIMPIREANLNCEDAVLKLRQYSSHFYLFLPRLRVEIVDVERAKLLFGDVSMFNEIKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2N0</accession>
    <name>A0A158Q2N0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS4836</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2N0"/>
    <dbReference type="STRING" id="318479.A0A158Q2N0"/>
    <dbReference type="WBParaSite" id="DME_0000047601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000047601-mRNA-1"/>
        <property type="gene ID" value="DME_0000047601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN54863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000047601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65486" checksum="1265528C348FD7A5" modified="2016-06-08" version="1">DSAIPTEGKELLDRKKIYQQDGEITWSTKCDFLLSVIGFAVDLANVWRFPYLCFKNGGGAFLIPYTLMVLLAGIPLFYMELSLGQYYKKGAITTWGYICPLFKGIGYCVVLIAFYTDFFYNVIISWALHFFFASFAKELPWTSCSYDYNSLACYTPSWNDQGSECIERLNSSQGISASEEYFYKYFLRLHYSGASNSSVARSLTNLGSINWQMAICLLIVYIICYFSLWKGIKMSGKVVWFTAIFPYVVLFILLIRGITLPGAERGIKYYIQPNLEKLREPSVWQDAATQVFFSLGPGFGVLMAYASYNPFYNNVYFDALLTSTVNCATSFLSGFVIFSVLGYMSCRSGIPINEVAQEGPGLVFVVYPEALATMPGASAWSIIFFLMLVTLGLDSSFGGSEAIITALSDEFAIIRRNREWFVAILFSFYMVIGILMCTEGGMLVMEWLIVYGASWGLIIAVLIEAIVISFFYGIKRFAMDIKEMLGFEPGWYWRICWTVAGPLFLFGTIVSSFMGYAPLKYQDYVYPYAANFLGLMFTFSAVSAIPIVAVYKFYNAKGNFKAVNFRFYIDPEPDSLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2Y0</accession>
    <name>A0A158Q2Y0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5463</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2Y0"/>
    <dbReference type="STRING" id="318479.A0A158Q2Y0"/>
    <dbReference type="WBParaSite" id="DME_0000110301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000110301-mRNA-1"/>
        <property type="gene ID" value="DME_0000110301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10047020at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000110301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="732" mass="84234" checksum="642F03F2B6EE7225" modified="2016-06-08" version="1">MDAEFIEKQAHAAALVQVAQLFQRADQLEKLESIKKRADRKKAAVEAMLRTGVQSQLEGIRTAIGHLSTTIEDVKIVEANLQEIYDTLGKFPELKEKMARLREANIKHSQYATAMEHLRHIYNIPEIVEKTHEFIVEGKLLHAHKNIMELEHARDDLTYELHKIQQSNVQYEINLVQELAKQLWYICSRCLEAVRGLDQGPVQLVTALRIIEREERIDKYYLDRKASSNNFMPVGRPRMWRQKCLEVIANTVRHRIEGNQLEDRSLNKQWLARYLEICRLVVVEDLKVAKSGAVQCFPPSYNIYDRFVRMYHNCLSSRLREIASENLEKNELVQLLSWIQAYGSEQMLGNPRLQINVAALTADHPLLPKSTITQLCDQFVEMTRKDIHEWLEKTLMQEKDDWYKHVHPEEESLGYFYTQLPSILFGMIEDTIAIANNLDICIDSTEKLTKHIRLTMETDVVSSENNETLNEEQSKNVPQSPRSPLLIGVSRQELLEKVDQLKKRWNIALQSAVGGLLDEVYEDIAPHLAELLTKKWLGGSSAIETICMTIADYHSDHKRLRPHLRCALMMELQYKIVGEYIIGIDSRKISFSHYEERSDAAALLKKDAERIANLFASLLSNTDMMFADLTAVLFAMADILSLRDKSLLALESTAFVRKFPDIHSELLSGLLQMREDVGRADARALAEETIGHAKCHIKSDPITKKLFQMCKTGSKRNFAFEETMQNMFATFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3A7</accession>
    <name>A0A158Q3A7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3A7"/>
    <dbReference type="WBParaSite" id="DME_0000200501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000200501-mRNA-1"/>
        <property type="gene ID" value="DME_0000200501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000200501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45436" checksum="8AB33AECFBC5A7F6" modified="2016-06-08" version="1">MQNRDFQANEDPSGRASNFHTTVARHFQALWSDVHHKQRSTICSMQNCAKIKRRKPYMKKMNTPGPEDLGANSDDETSEFMSFCAEHCSSSDTLSAADQTAETSMTLKSSEIEAYALEAAATRDKRRFSNPSFTDPCSTHYPANTDSPQTIRSNLPRCSSTPLVHYSRVPKFYQQFNVASNIASSIQVIPESFDEFSQFHVKKKNELFPLTASMSAKCREDEIVEFKKFVFCSSQQSCLLHKKLLRKESGKFQNSAKYCICRITRFLEKDQITDICITVNATSLLITGLLHLEIESISNVYKCIKIKKLNFGLFCNFIILPIKKFIIIVLYHCYLLSMTSVVALRAFRFFLNFCSKDFLHSIPSESTANHIIETALFDYCSSPQYWTVGTLIRRNFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3D3</accession>
    <name>A0A158Q3D3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6552</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3D3"/>
    <dbReference type="STRING" id="318479.A0A158Q3D3"/>
    <dbReference type="WBParaSite" id="DME_0000219201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000219201-mRNA-1"/>
        <property type="gene ID" value="DME_0000219201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857585at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000219201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40705" checksum="E7CE9695F64BF675" modified="2016-06-08" version="1">MIYFLGDLYPVKSSRSPSRDRSVTPFTDYESDFELRFVDALSRVSQKMAIPAPTFTASVSYDGMDDWDSAKEGSVASLSDYDDAISSNFFIYFVFYVFRISYCFIITAFFQYVEDEEYYEEESEWDEDEKSEEEEDDDEEEEGEEEEEEETEEKESSAEDEELFNAKDDKNLRNENKNEVKRYKRSTRLTNLDENKPKRTYGPIIKPVIDDSFDKQMKEIRESIKAGNQNLSSKVADLKKGISNVAGEAKRNILEEKHKSLMDEASQLFRFFGINQNKPTTVTPKEAPKVIDKPTMSVASIPLSNSSNTKQAAEKQKTSTSKNFEPSLSTNQQKSKEMATKQATKCIAFFLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Z6</accession>
    <name>A0A158Q3Z6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Z6"/>
    <dbReference type="STRING" id="318479.A0A158Q3Z6"/>
    <dbReference type="WBParaSite" id="DME_0000367501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000367501-mRNA-1"/>
        <property type="gene ID" value="DME_0000367501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000367501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="831" mass="91998" checksum="F0FC4877C5D35D0E" modified="2016-06-08" version="1">MADNVEYDEERNEESKDQDDGKMNGLVKSDRKQQQVNGYTDQRNLIPEPPDGGYGWVIVCIAFLSNFIVDGISNSFGAFVNIYQQHFNETKAAVSLIGSLLIGCYLLIGPVAGGLVNKYGARKVAITGSLISALSFAASIVSSNIYIFMIFYGVLGGIGFGLIFLPAIVYVSYYFESRRSIATGIAVAGSGVGTFVMPQICMLLLNKTGWQATVCVLAAFSLLCGIVAFLYKPLEPPSVKDDLEKEPLKDSEIDPRPMELFLDTPIAESPTKKAQRGLSSLANMDLVDIPSGMEPEKFARLRSALSECENPSTPVRPSLSPITEHPARAKRTESAYYTHAERAYSLSTRARKLTLTSTGSEMASTQDLKNRLCAPDQLSKISVRSYAQSMNRLNYCNQMKGAQSLLSVVCLSILNLDKRIKNSVRLSRGLIIAVTKMMCLQNSVHSKEFARPMNRRDIFYMGSICNLHEFVEEGRNYRSYRESQTCIPAAVASQELCGLSQVGDIVDIQSKISGSRISRVTGGVGPEEEELMEYFDDSKFKWLSLSVRSAVSEMIDIQLLKEPVMVLLCVSNLLSMLGFYVPFMFTIDMAIKLKIMPEKASLLLSIIGRIAFGWIADRGWISSLSMNNASLIICGLLTCACPFLNDFISLACYASLFGFIIAAYVCLTSIVLTDLLGLERLTNSFGLLVVSRGIASLLGTPLAGLICDLTNSYDISFCFSGSLIILSGLVSCVIPYFHRLRRDRIAYEVDEVKEMKAEDVQSGKLSVLTERSEENLTEYQRTIQSLRQQQKLLREYEEERKTALLNKSKKPQTVDESEESEDKNEIAHESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4C0</accession>
    <name>A0A158Q4C0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8397</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4C0"/>
    <dbReference type="STRING" id="318479.A0A158Q4C0"/>
    <dbReference type="WBParaSite" id="DME_0000451401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000451401-mRNA-1"/>
        <property type="gene ID" value="DME_0000451401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001729">
        <property type="entry name" value="Zinc finger protein 337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000451401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="59290" checksum="174B45B6E1FDBE00" modified="2016-06-08" version="1">MEVHQPLPTQYLHNPYIVKTEPPSSAPPTPPNKNINHTVTQRRSTNGPGDSLSCSSDHQLYNHNNNNANMHSKASTMMHNGRPLTADRKRPYKCDMCSSKFGSKMELEEHQNSHTGLKPFECTVIFLTSFLQKLLLIVDLDELILLCKARFNRRSTLWNHKRIHSDDKPFECSVCRMTFKWKNSLKCHKEMHQRKNEITGLESDPDEKTLTYATAAKRRLLEGHDIARTASCSTDSIHNNHSLNPTPRKRGAKSLNQRVVSTSTANGISSNGALTAPSDSFIHPPLQAEGFFSNQKTLSISDHKELDSLLSSTTRLTSMLKDESVFKTNIWFDLCDSQSAKKLVIIKYFSDDLGSIGNHSCVFDSKQEMNLFHANSFMVFGTHQLPSSVQGFAPTNLPLSSSNGSCNDYFHLHINQGDQMALSQNQPTIPLHSQAQYVESSSQAEMLMGHNVITYQSQVEAQNLLTSPNDYSLTPTNIDYMLNGYQSTLQDNSANAVRSSQDQLHYNQSVDGISAERPDSGKEVPQVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4C2</accession>
    <name>A0A158Q4C2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8422</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4C2"/>
    <dbReference type="STRING" id="318479.A0A158Q4C2"/>
    <dbReference type="WBParaSite" id="DME_0000453901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000453901-mRNA-1"/>
        <property type="gene ID" value="DME_0000453901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF48">
        <property type="entry name" value="THROMBOSPONDIN TYPE 1 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000453901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61124" checksum="F0FED19A38FFD281" modified="2016-06-08" version="1">MADNFTIMFLAVITKITMYLRAVATLSFIFEIIVAEQFCALTPVLHNVNKHQSLGSTYRKFLHEEKDCKKKCELDATFNCTAILWAAATTGECYLMDKVDLTNDIYRDDQHYTLFVMKCDGQDLPEIGFSLFLKAQENVSQPHGYGYRSPGLISEKACREFCAANYEGVKCSAYAIGNKPISQCFLYSEYPHSTGNGSMTIYRKVCRRSPHNCQYTVWSEWTVCSATCDGGQQSRKREILAKPSKNGIPCLEIEKIQTRRCGEVPCPGCTYGPWSQFSACSASCGKGTMTRTRNIIGPSGHHANQTACYHEQETLKEISEPTHCRHYYGPVSIQLNCERDDCEFEDEALTTTTSHSAISFIADELTTDEPFAQGINQWTPRIETTQIDEFVVAEAASIEILPSENTPCFLHGFIDRKIFLSEGSKYYLYDHQCRANKTKDTAICEWQSVATEIDLSTYPNKEPLGHIRSSQRCGTVCQLTYPTFVLKKICTAYAYTFNLTTNPDLDNCFMIDHQRFKSDDELDKLLVHGSGTYNVYFLSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Q6</accession>
    <name>A0A158Q4Q6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9173</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Q6"/>
    <dbReference type="STRING" id="318479.A0A158Q4Q6"/>
    <dbReference type="WBParaSite" id="DME_0000537401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000537401-mRNA-1"/>
        <property type="gene ID" value="DME_0000537401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000537401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30779" checksum="EBA3F77D185619E3" modified="2016-06-08" version="1">MYRMRTSQREKIRSFMVWTKSNEKVATDYLNHTGWNLEKACDLYYRYPKMFHSESVASVVDQRNLKAFFTKYANDARDDDSSIIGPHGVLRLLNDLELDPRSRTVLILAWKLNAKTSCEFTWKEFSTGLTDMRVDSLEKLRAAVPEMANELQDPIKFRDLYQFAYNYARTSNSKNISLEMAIAYWELLFDKSQDFLESWFSFLREKGVGAISRDTWNLFLEFIRNIRPDFSNYDVDGAWPVLIDEFVEYSKDKMQSKIQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4V6</accession>
    <name>A0A158Q4V6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4V6"/>
    <dbReference type="STRING" id="318479.A0A158Q4V6"/>
    <dbReference type="WBParaSite" id="DME_0000584601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000584601-mRNA-1"/>
        <property type="gene ID" value="DME_0000584601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="48"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000584601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40293" checksum="1A36A51167131F2E" modified="2016-06-08" version="1">MPTPALLTYNNRELGDFEKSNEVDQKAETFETVEDFLAKYADQKFARPINKLLIANNGMAAFKCVMSIRRWAQETFKDDRRIKFINLTTEQEVASNPEYLKMIDNFVFSESGGNESNYANVDEILKHSVSGEVDAVWAGWGHASENPDLPNGLMERNILFLVPVLPWSGSNIFLPEEDCQDYRTDIEVSEEIRQRACVTNHEEAICVLKEKKIPYPVMIKASEGGGGKGIRRVTCEADFEISFRRAEVPGGHIFLMHCLEGARHIEVQLLGDMYGQVIALRTRDCSVQRRCQKIIEEGPAIAAPTYVQKSMEADAVRLAKMVGYFSAGTVEYLYLPKNQQYFFLELNPRLQVENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q512</accession>
    <name>A0A158Q512_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma-secretase subunit Aph-1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1104</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q512"/>
    <dbReference type="STRING" id="318479.A0A158Q512"/>
    <dbReference type="WBParaSite" id="DME_0000620701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000620701-mRNA-1"/>
        <property type="gene ID" value="DME_0000620701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000620701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28076" checksum="B1A0EE4855024C95" modified="2016-06-08" version="1">MTAWLGFGCLLISFSPTLVIFFRVIASDPLRVILFVLGAFFWLISLLLSALIWYIIVPLRNVLAFSVFVSIAFQELARLIHFILLKKAQRGLSQVAASGMHISGVHTLHHARHILAIVCGLGMGFMAALFLIVNVIADFWGKGTVGLPTTVPQMSYQFSVKLYAEDQTLPLTSSVSACLLTMFHVTWTIILWDGCHKKGLKSNWWIEIVLAVASHYVVSGLVSNNYFFNYFLISLSYDLYFFSPYFWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q516</accession>
    <name>A0A158Q516_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress-induced-phosphoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1128</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q516"/>
    <dbReference type="STRING" id="318479.A0A158Q516"/>
    <dbReference type="WBParaSite" id="DME_0000623101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000623101-mRNA-1"/>
        <property type="gene ID" value="DME_0000623101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000623101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39685" checksum="0D2A18684950DE6D" modified="2016-06-08" version="1">MESELKIEGNALVIFPEKLSKISMQMATIEALKEKDLGNAAYKQKKFDEALGHYDKAIELDPTNMTLFSNKAAVMFEKGEYENCIELCKQAVDVGREQRADYPLIAKVLTRIGNAYMKMDQMKEAIVWFDKSLSEHRDQELLKKKKNLEKLLAEKERLAYINPKIAQKEKELGNELFKEGKYPEAMKHYNEAVKRDPDNAILYSNRAACYTKLMDFQRALEDCETCIKKDPKFIKGYIRKGAALSAMKEYAKARSAFEAALALDSTNVEAREGLTNAIRNDDEPIEQARKRALQDPEVQEILRDPGMRLLLEQMSNDPGAVKEHLRNRDILQKLLKLQEAGIIQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5M0</accession>
    <name>A0A158Q5M0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10149</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5M0"/>
    <dbReference type="STRING" id="318479.A0A158Q5M0"/>
    <dbReference type="WBParaSite" id="DME_0000773901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000773901-mRNA-1"/>
        <property type="gene ID" value="DME_0000773901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="11">
        <location>
            <begin position="823"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000773901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1213" mass="139639" checksum="7FB20736DD17BC20" modified="2016-06-08" version="1">MQKVNSTKQLCNILDKNLSRGKFEVDLSSFALLFAEMIRYANNRSNTVSDLQDKLADYGRFVGSRLLDVIVFREKGYRRETKLLNMLMFIKGTIWKNLFNKEADKLERSNDDPCQYLLIEREPIVNTYISVPKDKGNLNCASFIAGIIEAMLEASNFPCKVSAHWHNGTTYVLQFENQIVKYSRSSSNKQLSVRSSILKPIELVPERIHRHLFGETSVNSSNLNDIYEDLELPERSEINLVKHFEQIATNQIAEYKRQLDEAAVFRTVPDMPKLWSFQSGWIKYLPDSGEPIKIECPDDGPLFFDVEVCLRDGQLPTMAVALSKNAWYSWCSNRLINDSKIPILNRFSHLIPLESRDNKKPKIVIGHNVAYDRSRVREQYYRNSANTRFWDTMSMSIPIYGMADHQVSLYEKNDLESGEKLHSAWVDDWKARVCKNSLNAIHDKLCNGKDSSLNKSLQMFFLREPIEEIRRNFQDLMKYCARDVFATFQIYQVLYPEFVKRFPHPATWQGMLEIASVYLPVTSNWRKFYEICEKRTTDENKNAVQGVINIMNALVDDFGKNNRLLISAIRFLFFNASYKDDPWLWQENWDLHKDTIPVWCKNMLLKTDIPKLTAETISSSDVKLKSRSIPRIFGLCWGPYPLHFKIDLGWGFLVPKAYNGGKLDALTRVSLRRVLHFRAILDLINANISQGIGDVILNKPASSVGVFDFYRLPHPTGGDTNVGDPLSKGFYRNIEEGILYPTRFKDEFHALLNAKKMTRFWGNYRLQFLKARFEEQVTIWYDEGGTEGAIAPSIIPAGTITRRAVHKLWLTAINAKDDTTVIGADLKSVVECPEGWYMVGADVDSQEQWIAALFGDTAVGEHTAGCTPFSNMLLAGSKADKSDLHSVVAKEVGISRDKAKILNYARLYGSSINHAVDFLKQSGIDERQAESMARKLFATTKGSQKYYLQLSPSLNDNFRWFIDNICPNEYRSDFIQLNGQYFLPDYRTETSSLTVTFEKWILSEIQKNISEELNIPVFLKQMYLDDGRPLQLYFGGFESETFNYLEMVIKEEKPRTPILGCRLGFALQPLSKSVPDQEHFIRKYKRSIINWVVQSSAVDFLHLLLVCMKWLCEKYEINARFALSIHDEIRYIVSAEDRYRCALALSLSNMYVRAMISQKLGINQLPMSVAFFSQVDIDKILRKEVKFIYNMPGGKQVLPGKKVFQKFNMSVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Y7</accession>
    <name>A0A158Q5Y7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Smg4_UPF3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10442</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001217">
        <property type="protein sequence ID" value="VDN60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Y7"/>
    <dbReference type="STRING" id="318479.A0A158Q5Y7"/>
    <dbReference type="WBParaSite" id="DME_0000859501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000859501-mRNA-1"/>
        <property type="gene ID" value="DME_0000859501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="UPF3" evidence="7">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000859501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51844" checksum="1F15F83AB80986CB" modified="2016-06-08" version="1">MSSDEPEMASENISDKKEKIRRKAPIKIVLRRLPTAMTWDLLQTQLHPLPETDYCEFVAADPDERFSFARVYFVFKNDEDLIAFKNRFNGYIFIDSNGQESMGLVELAPNPKIYRHKLEDSKKRDKRCGTIESEIEYKIFLDCRENPVKPEIVPIEKRIREIEEKERLALGMILIFIIFFSFSSSFNTSFFKILENSVQETPLTQFFMKKMEEKYKRLKRVREDEKARRSARDEEKRIRAIRLQEKILKVCGAQHNEAKNVTEFYNTKFDKKIDEHNTEKEKEKKKKRCFQQSSSGYRNNNDNERINSIKKDKEKTESIKLRENSDEACNGIKEKLIERINLSHKSISKKKVTKNDCSESLQQNLEKNSDAKSSDTHTGSDTFEEKMLQKERLSGDHEEEANKIRRRNKDRPERAIYQPAARRRAAALANTLGTSSIAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q610</accession>
    <name>A0A158Q610_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DHC_N2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10471</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q610"/>
    <dbReference type="STRING" id="318479.A0A158Q610"/>
    <dbReference type="WBParaSite" id="DME_0000878301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878301-mRNA-1"/>
        <property type="gene ID" value="DME_0000878301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="12">
        <location>
            <begin position="530"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1313" mass="153803" checksum="7BE0554D019605C3" modified="2016-06-08" version="1">MTIEKKKGILVVNYNDDLPKLLKEIRQLASFGFAIPKKIIHCAKTAETFYKYAIVLKQVAHFYNTIELQMLPCQQAMMLNEALAFEKLIFMDKKDDTICNKITWDNPKELENFIKKLQQAAERLVLRNRNLQKAHSEIGDKVKQLMEHDLLKGIDKWKDIMTDIRTQFVEQEKYIGNRIHMRTWIIHWEIQIYKLEAIKLLFYCFKVLQLQYRWGIESFHMQISQIDTQLVFKDQCLQLRPPMEEIRAKYYREMKKFLGIPQKFRGIQDSDQEWVLLGKVDLEELIEDNFKKPSDWETHIKLLKAKSREAEKLPNEIKLECIVVNTSAIKRTIDDLLQRLFDTLIWTLRHSINTQTQAISRFLNDAIKTLSSRPQTSDEIAEANYKHTQFAKTNNEMKQTLIAIDEKNILLRSVSGSGAEQVTTIVQQWGNFEMLLNSHQSMIKEQVENLKITIFNRTKDFSEQIDKFSAKWNQLKPKNDILNDTKELLLKAIEIIKEMRNECDQIIKIREKVRLECEYFNIEKIEFPILDEIDNEIRNSENNWSLYEKFSSGLEEMAGKEWILFRSKTYNFDEYLQEWFNKLKIMPKSPITIRIIREIEEYKDMSEGFKYYRGEMFSNEHWIELFRILGLPKGTTIESLHFGDLLKVHHSIISNVEKLRDLNARAQGEVTIREALQELELWAAQMEFSLLDYKLMNGSMIKIVKNWKELMNSVKDNQALFLSLKNSPYYPVFSDKIAIWETRLTDIDLYLHWLNEIQRKWIYLEPIFGRGALPSELSRFNRIDVEFQSVLNGMRYETLTEFHLDIRQDSRIMSLCSRHSLKGTLEHSIDQLNRCQRALNQFLEEKRRVFPRFYFLGDDDLLEILAQSTNITVIQAHLKKLFQGIHRVAFNDDSKLIIAMVSAQGEYVALMKPVQIVPQAEIWLQELLDIMRKTIKALINQCVYESSPNPANYPSQVLCLSEQIRFCNECEKMIESKEYLTELRKKLCQQLQNYTATQVEDEVLNLKLKCLILDLIHRISIIDDLINNHPCKATSWVWQKQLRFYLDRSSQNIVIRHVKAEFEYTYEYQGNANKLVHTPLTDKCFLTLTQAVSMGLGGNPYGPAGTGKTESVKALANLFGRQVLVFNCDEGIDVQAISRIFIGLVESGAWGCFDEFNRLDEVILSAVSMQIQIIQDAIKSSHPFCTIEKREMKVNRNSAIFITLNPAGKEYGGRKKLPNNLKQLFRPVVMAVPDNEMIAETLLYSKGFKEARILAKKLVTIFDMSKSLLSSQQHYDWGLRAIKTVLGGCRNIMANERKTDENQIIIEVRQTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q658</accession>
    <name>A0A158Q658_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q658"/>
    <dbReference type="STRING" id="318479.A0A158Q658"/>
    <dbReference type="WBParaSite" id="DME_0000914301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000914301-mRNA-1"/>
        <property type="gene ID" value="DME_0000914301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000914301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25510" checksum="D92E9B0F461FE780" modified="2016-06-08" version="1">MVEKIDEVGKNSLRESWLYLTQDIERISIRIFESIFQKCPEAKKMFPFMVIEDFGDEKRSAGMRFHALRFMQSRNFKIEYFDIFHEATLIHFKNALNHFPASRPKRKHSTIVAGNLNISYTIELWDVVLKFLIDAMKLSLLQGLQERQTFSHLQNMVESDNKVNRKPLQEDGSEKVESGKVETKIILPKGPVRTQRATNRPKIFCIQKLAKCFGRVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PSS5</accession>
    <name>A0A3P7PSS5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PSS5"/>
    <dbReference type="STRING" id="318479.A0A3P7PSS5"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000044">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="313" mass="34900" checksum="B79DFB7A460F7507" modified="2019-02-13" version="1">MEAQYYGEISLGTPPQKFNVIFDTGSSNLWVPSKQCPWTDLPCRMFFHNKYDSKKSTTYKPNGQKIEIKYGTGSMKGFESLDVICIDQICAKDQEFAEATAEPGITFLMAKFDGILGMAFPGISRKKNLQFRSIWDVMFIGIYRDPNAEFGGEISIGGINPDRYVEPLSSPVPVTSKRYWQFQMDGILGGGEPIAIADTGTSLIAGPKEQIEKIQDYIGAEPLFKGEYTIQCDKIPTLPNVTLVVNQKSYILTGEEYVSQMGKTICLSGFMGVDLPGVELWILGDVFIGRYYTVFDVEKAQLFFAQAKNSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QAS3</accession>
    <name>A0A3P7QAS3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QAS3"/>
    <dbReference type="OrthoDB" id="5870055at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="113" mass="13249" checksum="1418A4B49A0061A6" modified="2019-02-13" version="1">MNGIFQTFVDPQSDCRIHCLNGGFCAYLVDNPTVHTCLCLLDLFHGDRCQYSVNYKGSNRRCFRLDCLEKRKKIRLLVLEKRTKNLYKPFLSPSGIELTIYSFNLTFLLFRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QC68</accession>
    <name>A0A3P7QC68_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000126">
        <property type="protein sequence ID" value="VDN53381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QC68"/>
    <dbReference type="STRING" id="318479.A0A3P7QC68"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="239" mass="28062" checksum="D69C3F99C1CA983A" modified="2019-02-13" version="1">MFGESKCKLFLNICHCINVPRPIEDYDEDKIAEIIDSDDPGRYRIPLSVGELECIRDNRNENCAKIDIIVNSTFYAERLEISEFFRQLLLLILTDALDAKHKIKIDLKKAVQLKNRRVMGDLSTQRIKKEPANKFIQETVEPAEEENLIFDNYLPRNCLLFLKRGKEFELLIKFPKENTPIEDPKRLCLKINDDRLVLILDRRRTIADVYFPFKINYDNPNVELFVDKDTLRVTAAVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QIX5</accession>
    <name>A0A3P7QIX5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="13">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QIX5"/>
    <dbReference type="STRING" id="318479.A0A3P7QIX5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="280" mass="31546" checksum="1FF6A43CD502ED11" modified="2019-02-13" version="1">MLRFIDCLLFQLITLKDHEEKYALPLISKKLINHDTRRFRFKLPSEKHSLGLPVGQHVFLSAKINGKLVVRPYTPVTSEDEKGYTELVVKVYFKDVNPRYPEGGKMSQHLDSLNVGDTVDFRGPNGLIIYKGRGKFAVRPSKAAIPVEHYYRELGMIAGGSGITPILQVVQAILKDSGDTTKMSLIFANKSEDDILLRKELDELAETHSTKFKVWYTVDNPPLDWKYSSGFISTEMIQAHFPKPSDTTAILLCGPPPMINHACLPKLDSLGYSSKNCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7R0I2</accession>
    <name>A0A3P7R0I2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7R0I2"/>
    <dbReference type="STRING" id="318479.A0A3P7R0I2"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF19">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="195" mass="22526" checksum="CC0E401639EF98F2" modified="2019-02-13" version="1">MIIEKNFKNQARFNIEEAQEVLFWIEQVTEQPFDRHPATMQTAQDVADALKDGIHLCRLFNRLVNKVDALFYNKRPKMPFQKMENISNFLDAIKSYGVSEISCFQTVDLYENKQCYKVIECIRALAAVAQSKKCLAPLPPWVVRLSQQRPRYFSNSVIRSGEMVIPLQYGTNKCASQKGMTPYGLMRQIKPDNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SCF9</accession>
    <name>A0A3P7SCF9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SCF9"/>
    <dbReference type="STRING" id="318479.A0A3P7SCF9"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="60641" checksum="3FC6E4C831619121" modified="2019-02-13" version="1">MNFGQINNFKVYIAPPFETPVITGSPHLVEWFSDLTAIGNKWIKSSGKKDDAENSVSKYDGEWEIGPPSKIVSDGDYGLIVKSKARHHAIASKLAKTFEFDGKPYEVKYEDGQECGGGYIKLLTIGAEHKLAEFTDKTPYTIMFGPDKCGSTSKIHFIIRLKNPKNDIISEHHAKQSSKSLSGYFDDRKTHLYTLIVRPDETFSVLVDNSQIMSGNLLTDLEPSVTPPKMIDDETDKKPADWDDREKIEDKNAKKPDDWDENAPQEIEDDKANKPVDWLENEEPMVPDEAAEKPVDWDDEMDGIWEAPKIENPKCKGVSGCGPWKRPMIPNPAYKGKWKRPMVSNPDYKGKWKARQTENPYFFEPHPYSQLQSISAVGFELWTMSGNIIIDNIFVGNDESAASSFAKQTFTVKSSQVPLYESASSPSEGIVNKMISATEERPWLWAVYILSILIPVIIIAITCFGRKSRPSTSDYKKTDEAQADDDDDIPNLVGDDDDLEGTKEEIKVADEERSASRSRSTSRGRNGNAKVIYILIIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SFE1</accession>
    <name>A0A3P7SFE1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dosage compensation protein dpy-30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000161">
        <property type="protein sequence ID" value="VDN53666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SFE1"/>
    <dbReference type="STRING" id="318479.A0A3P7SFE1"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000003">
        <property type="entry name" value="protein dpy-30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12252" checksum="246051D4F08E17EB" modified="2019-02-13" version="1">MPKATDPPQQTIAESTEASAREKEKEKKEVCEMKKKIFQGEISGDVSSSNTALSTRQYLDQTVVPILLQALGALAKERPPNPIEFVANYLMKEKDRFTVATPTTANTEASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SRT0</accession>
    <name>A0A3P7SRT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SRT0"/>
    <dbReference type="STRING" id="318479.A0A3P7SRT0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001822">
        <property type="entry name" value="RAB family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="242" mass="27834" checksum="309387090A623B62" modified="2019-02-13" version="1">MQIDDMDNRGCTSQVDLRRSIYNPEVKQSPSSRSLAEVFNYHTKSDFSPERIFKVVFIGDSAVGKTCFLHRFCHNRFKPLFNATIGVDFTVKNIRLGNRTVAVQLWDTAGQERFRSITKQYFRKADGVILMYDVTSEQSFLNVRSWIDSVRVGVDEKCVICLVGNKVDLFANDRSRVLTYKQGQNMAEEFNMLFFETSAYTGYGVNECMKAVAMKLQEREDENIEEALKLDMNIQKAKKCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SUL0</accession>
    <name>A0A3P7SUL0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WAPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SUL0"/>
    <dbReference type="STRING" id="318479.A0A3P7SUL0"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="2">
        <location>
            <begin position="33"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="464" mass="53051" checksum="6B9A38E7B4162C3D" modified="2019-02-13" version="1">MVYKHKFFDDDEIERKTDTFMSFYRSPNIIGPNTGKALIETRVKNVKEAHQCLESGAKDDFTDDIEYALSTLTDPLSTPSLKCLSIISLSRKCISSEFRQFFRSQNFFGKIVKTLGDSNMAICISSMIYLISRDTVSLDVDAVSLRLFNQLLKWDKPKGNGEYMRFSKMSFFQPSFLVLESLVYICARKTDNQILKKELLNLGILQWIVSKCKFFYTCLKILERCLRVLESAIVCNKKNQAFLISHRGSLLIQSSVKFVPFFLLFEQSITCLSRVAGLLMNMSHENELCSTKLGQMSGFLPLCMSSFTYLVPKFAAKEKRFDLTVLVSVIIISDETIHRNLFVTVLFVYHESIARSIDEELDNDLVLEDVPDDSNCTDDDDDGRLHRLPAELTEDEMIETVQKAMNKASKHMEDSVLASYFALLIGCLLQQNEVIKSELSGGKLTLMIEQLQRFLEFMKISIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T058</accession>
    <name>A0A3P7T058_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T058"/>
    <dbReference type="STRING" id="318479.A0A3P7T058"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000389">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="563" mass="64943" checksum="614AF5769EE3C1ED" modified="2019-02-13" version="1">MGSGTYGKVSLAYDHKTEREVAVKLIKKSAIENKQDLVRIRREIRIMSALKHPNIIQIFEVFENRDKIILVMEYASGGELYDYVGKYGSLPEAEARRIFRQITSAVLYCHKHQVVHRDLKLENILLDHSNNAKIADFGLSNYFSDKTLLTTFCGSPLYASPEIINGTPYRGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFEPDTPSTASMLIRNMLRVNPERRADIYEIANHWWLNLEENMPVIQELPENQITDSTPLIDRAETILVQDLADETDVFMDFGHLSAATRLKIEEFRRRRKDAEDYIENSPVKPPKARKTDKIEEKQLTTAEKSLRGENLFEQQKPTSNVLNDIKDDFNEPLERLKQLETRLQSTANRDSRTKDKNLISNPSSAWQTMEVTKSALYAQKINPERPNDFEVPHFKASGYDSTHRYIPVETRRPSFVPLNSEVPSHRHEIRAINIQTWRMETDLLNMLMNQISSHYTLAMSPFKVLEQMENGPVSMNLIARIKAHPLYDSRPMVKELLESIIAAQPPSVQKQASKIIQQQSQVFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0K5</accession>
    <name>A0A0N4U0K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4449</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0K5"/>
    <dbReference type="WBParaSite" id="DME_0000008901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000008901-mRNA-1"/>
        <property type="gene ID" value="DME_0000008901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799079at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF13">
        <property type="entry name" value="CTCK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000008901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23619" checksum="793E7B2D48BADF74" modified="2015-12-09" version="1">MNKQNTKSYCRKFGINELQKRLEKIGGLNQAFMANTPEEAGLHYGYNDHSNSNPYINQLYAEAIDVSVFSPVYSSMDFIVDSRNLIKKISFSGIFIPASDCVLEGDEEILGLSKLCSSCKGVYLLGKNCFPRFLNSVICGAKNALCIFDSLTKRGHGECKSKTLNFKVLQNIGTEECQKWNVRFIEIPVTCECYLKQQSPLLKASRNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N0</accession>
    <name>A0A0N4U0N0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein VbhA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4476</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N0"/>
    <dbReference type="WBParaSite" id="DME_0000011601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011601-mRNA-1"/>
        <property type="gene ID" value="DME_0000011601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874942at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11732" checksum="6453EAC7C5047669" modified="2015-12-09" version="1">MSPYAIYLTEDDQKALFELITEARKEGADEGTIKGYMYKYIQKLLSPEKYKEFTAANEEFEEERRRNVCRSDSRQPKTGWEIPQKVIKNNKYLPINQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0W6</accession>
    <name>A0A0N4U0W6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4572</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0W6"/>
    <dbReference type="STRING" id="318479.A0A0N4U0W6"/>
    <dbReference type="WBParaSite" id="DME_0000021201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000021201-mRNA-1"/>
        <property type="gene ID" value="DME_0000021201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000021201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12028" checksum="5ABE3656C96D8D6D" modified="2015-12-09" version="1">MVAVEALAVGLKTGYKVTKNERKPRQSRRKGRLTKKTKIVRELVREVTGFAPYERRAMELLRISKDKKALKYLKRRIGSHKRAKRKRDEMQAVLTSLRKQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U140</accession>
    <name>A0A0N4U140_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U140"/>
    <dbReference type="STRING" id="318479.A0A0N4U140"/>
    <dbReference type="WBParaSite" id="DME_0000029501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000029501-mRNA-1"/>
        <property type="gene ID" value="DME_0000029501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000029501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43313" checksum="9EB5991454872247" modified="2016-06-08" version="2">MKQNKSREQTDDTSALELEILAASLLWFMILEYYPMYWTVNIQGGPKRVNHAAVALNGAIYSFGGYCAGETQRVRPIDVYVLNPSIIILNFCGFFFFFSETYRWKKIKPNFEYYEKVEIFTDNNNVDVVLTPSDIPMQRYGHSIVAYKNKAYLWGGRNDQFGDLNVLYEFDPGTLRWRRIICEGNRPSGRDGHSAAVFGDKMYIFGGYEDSLERFTRETYEFDFNHSRWQKLRTTGDLPIWRDFHSCCIYDEKMYVFGGRGDLRGDLNGKDEVYSTEVSLLDLKSLKWCQLVANGDKPCGRRSHTAWFYKDRMYIFGGYNSQVDQHYNDLYEFNPSNLKWRKIIAQGIPPSARRRHCSVLLGSRVFSFGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U172</accession>
    <name>A0A0N4U172_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS4696</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U172"/>
    <dbReference type="STRING" id="318479.A0A0N4U172"/>
    <dbReference type="WBParaSite" id="DME_0000033601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000033601-mRNA-1"/>
        <property type="gene ID" value="DME_0000033601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413723at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000003">
        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015792">
        <property type="entry name" value="Kinesin_light_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01160">
        <property type="entry name" value="KINESIN_LIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN54723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000033601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53593" checksum="EBBD0357891FB21B" modified="2015-12-09" version="1">MTALSQDEILQNTRTVVQGLEALKDEHESIKGTLVNSMQGLSADESALIEEKAHIVEKNLDLLRLGIEEAQVMMALAGHLQTVEAEKQKLKAQVRRLCQENAWLRDELNSTQQKLQASGQQVAQLEEEKKHLEYMNSIKKYDDPQESDRNIDHAELRSSEHTLQDLGFGPEEDEEMAGNIAGQFNHPTPAHSMAASASAGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNEALHIREKCLGESHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGTDHPDVAKQLNNLALLCQNQGKYDEVERYYRRALEIYEAKLGPDDPNVAKTKNNLSSAFLKQGKYKDAEILYKQILTRAHEREFGKIGDDNKAIWQIAEDNEEKKHKGLDSSTYQEYGGWHKAAKVDRYRLSEVRLINSVPSAVTIPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U176</accession>
    <name>A0A0N4U176_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4700</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U176"/>
    <dbReference type="STRING" id="318479.A0A0N4U176"/>
    <dbReference type="WBParaSite" id="DME_0000034001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000034001-mRNA-1"/>
        <property type="gene ID" value="DME_0000034001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000034001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47429" checksum="45DAE9690E149A58" modified="2015-12-09" version="1">MASLNSIDEVLYECSCGEWKSLNRLYFCRYCSELKCSFCTIQEMDSPFCPSCLYNYCVGDALQQRNRCSNCYQCPLCGLRFLGVGVVVRAANDCYHLSCNNCRWTTSDSGIPDMNSSTGWPEYTNDDEDLLNSIVESMRNFASIEGADHIRHKYMKRRSNLGALSNRFGLQAIYNRHKNALVEQNKCLMSAVTSTDLVPKLDLSIFTEAEIDPGSIPTLMQRTNQPFANDRLHLPNKVRLICRRSMRCKQCDHSLCKGEYNSSSVQFKIQVLAGNIVPDLRLSRPATLVAGHICPIFLTVSNFSSSPTKVAIMGDIVNDPSFVKCETPVVEFSIPNCDEEMDLDDISEKQPNENEAIIFRKRHRFGIRLMVCATEGHKKFLALIIKYSNSSTTFETMAEQNWLQHRVKIALGDSPFLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U196</accession>
    <name>A0A0N4U196_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1146 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4723</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U196"/>
    <dbReference type="WBParaSite" id="DME_0000036301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000036301-mRNA-1"/>
        <property type="gene ID" value="DME_0000036301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000036301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10303" checksum="C40646367577460B" modified="2016-06-08" version="2">MIQVIFFFFYIQFTRRKLKTKNTIDYGALIIKGSAAIVIVISLSLIFLAVGNMVYQSFASNAVLRQNVSKNFLKFSLVIRIFFFFNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1I7</accession>
    <name>A0A0N4U1I7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4832</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Ubiquitin-like modifier.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1I7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1I7"/>
    <dbReference type="WBParaSite" id="DME_0000047201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000047201-mRNA-1"/>
        <property type="gene ID" value="DME_0000047201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01766">
        <property type="entry name" value="Ubl_UFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038027">
        <property type="entry name" value="Ubiquitin-like_Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000047201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9795" checksum="D45257C399B46389" modified="2016-06-08" version="2">MASTQSKVTFKITLTSDPKLPFKVLSVPEATPFTAVLKFAAEEFKVPAATSAILTNDGVGINPSHSAGNVFLKYGSELRLIPRDRVGYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1Q6</accession>
    <name>A0A0N4U1Q6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4913</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1Q6"/>
    <dbReference type="WBParaSite" id="DME_0000055301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000055301-mRNA-1"/>
        <property type="gene ID" value="DME_0000055301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871299at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000055301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26945" checksum="600F3542E7C6B21F" modified="2015-12-09" version="1">MINCLFIVNIFSEREEKEKRLSSSDMLLSHLSSTYHQEKSSSAKQQNLIINKQKSCSEGNRVIELGDTKMECVPLLRVVCDADTNEEEDEEEKKEQDYENYGFLLQRNDSNSHGCVIGDPKQHCTSFHKCSFASSSSPTSPSTNNSLLFSFPNTQSCLLNNASMSLQQQQQEVKQGEERKKEEDDDTDDNILFSKNNILRKLPKYSIIEEINRLTADIAAAHPDMIHFQQVINTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1V0</accession>
    <name>A0A0N4U1V0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4971</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1V0"/>
    <dbReference type="WBParaSite" id="DME_0000061101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000061101-mRNA-1"/>
        <property type="gene ID" value="DME_0000061101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000061101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8788" checksum="2E1A300458FA4D86" modified="2015-12-09" version="1">MEVHMSSGNGQWRTTIRYCSYGACDMGSGTQLGIAAMVLAIWTVAYNNSVLQLWCLRPQCKQYAIALDCSFDYFNHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U231</accession>
    <name>A0A0N4U231_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5066</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U231"/>
    <dbReference type="STRING" id="318479.A0A0N4U231"/>
    <dbReference type="WBParaSite" id="DME_0000070601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000070601-mRNA-1"/>
        <property type="gene ID" value="DME_0000070601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000070601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9593" checksum="9E9A532FF6AF70BD" modified="2015-12-09" version="1">MGVVSEESVRKCLNEALKPSHLEITDFSDGCGNKYNILVVSEKFDGLSTLESHRLVQKALGDKFDHIHALSINTYTLEKWKNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2P7</accession>
    <name>A0A0N4U2P7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5327</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2P7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2P7"/>
    <dbReference type="WBParaSite" id="DME_0000096701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000096701-mRNA-1"/>
        <property type="gene ID" value="DME_0000096701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF187">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000096701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="51046" checksum="F52FF1F6FBF96A1E" modified="2015-12-09" version="1">MRCLSVSEVPKDPIIAQTVPELVKEFCQFLENPLNGSEGLVASETGKLRAVLIIFRHGERSTLHKGNREEIESFDCTPYYEGDRQAFSDYKKLVFSEHFEDFYSFNKIFESFPRIPNLSQCTFGDLTAEGALQLIKLGNFLRERYTSAGFLFDSGQQWEISIASTLYNRTYQSITAFIATFLYPLHSLFKRIYIEASDNIHFCMDISCACSNILRLRELVEQEKSQFFISRYNKFISRLNVLINITNTDALDPEHFFDVLLGCYLCRRMPLPCQNNECVRFDDFVQFSDIVSDRVVQMLDESHSLRKLVVASSSAILQSFRDLLLKLKSHPRTVSLRLYSGHDTTIFPLLIALNIKHREPPHYASRLVFEVYEKSSINRESLFFRVIYNGMDRTEDLSFCSTYLVDNMCPSWIFQRFLKVDFYQIVNIRALSEICDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2V5</accession>
    <name>A0A0N4U2V5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxin/Ferlin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5393</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2V5"/>
    <dbReference type="WBParaSite" id="DME_0000103301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000103301-mRNA-1"/>
        <property type="gene ID" value="DME_0000103301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000103301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18700" checksum="D12D56E0A691AC8E" modified="2015-12-09" version="1">MFDDSFKSCLNQRHTGHCYTYLCNTYTTIRRTVSTYENHAVRQCLLEILGPRWYPLFGWSSRTLPSDRAFFTDETVDIIQPSNSFDSPSVGWEWEQAWMIDTNEQSYDKEMNFVSVSEYFMDIFVGGFDISDSESSFSLFALSFDGVIFMLMSISRSKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U391</accession>
    <name>A0A0N4U391_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5548</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U391"/>
    <dbReference type="WBParaSite" id="DME_0000118801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000118801-mRNA-1"/>
        <property type="gene ID" value="DME_0000118801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000118801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14086" checksum="1BA29E65918CB7D6" modified="2015-12-09" version="1">MVICSKCVLFQAKLNPSKKSFLEILLASQQGLSRLEIADSSSKCGKENCRLGEVIWDVACRQIGDKCGINMIFNLNSEILKEKSCVIRCECEREFIEKGGQCVRALIFKRKTTSERTTTDFISPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U393</accession>
    <name>A0A0N4U393_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U393"/>
    <dbReference type="WBParaSite" id="DME_0000119001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000119001-mRNA-1"/>
        <property type="gene ID" value="DME_0000119001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000119001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11485" checksum="A924FDB5463CD298" modified="2015-12-09" version="1">MKCVCDNGYSLIVDRCTNQDDPLYKIQKDLELKRFYKRIHLMRKENPNITVVSQIICPSKMVLVEHICPPSENWGLNCYRICKCMDGLQKRGDNCVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3B0</accession>
    <name>A0A0N4U3B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5569</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3B0"/>
    <dbReference type="STRING" id="318479.A0A0N4U3B0"/>
    <dbReference type="WBParaSite" id="DME_0000120901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000120901-mRNA-1"/>
        <property type="gene ID" value="DME_0000120901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000120901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="23954" checksum="30841F47649D0E36" modified="2015-12-09" version="1">MRKTRRILSTFFQKSELSNIGLTALTRHQLSLIYGKDSSHEEFIILHTLTTIMNDDHFQKLIKYICQLAKRSLSKKGLFIKKLDMRPSFNRTSKLTPVILSPGILNPSVLSPSILGPVILSPGLFNPSFLCPRLLGPVILNPGGFSPLVLSPVALSPVVLSPGVFGPVVLSPTALSPGALNAGFGSPVVLSPFILNPGLLNFSAMSPLILSPFAFSPSILSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3C1</accession>
    <name>A0A0N4U3C1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3C1"/>
    <dbReference type="STRING" id="318479.A0A0N4U3C1"/>
    <dbReference type="WBParaSite" id="DME_0000122001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000122001-mRNA-1"/>
        <property type="gene ID" value="DME_0000122001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000122001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22163" checksum="855AEFD28E1280D2" modified="2015-12-09" version="1">MEWCEMGSLDDLLKSQHPIPLHRQYLARIICGIATALHFLHKQNIFHGSVYIDNILIDHNMVGRLAGLSTCQMISQNTIIKPYRICSYRAPETYGEKIQAFPQDMFAVGVILYRCLIGYLPNRKKNGEVDYHGLKSSLHIPLDSEMWYTTQLLLSNKLDFRPTAGQLLYTDWIIRSKTERIKRIFNWNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3I9</accession>
    <name>A0A0N4U3I9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5654</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3I9"/>
    <dbReference type="STRING" id="318479.A0A0N4U3I9"/>
    <dbReference type="WBParaSite" id="DME_0000129401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000129401-mRNA-1"/>
        <property type="gene ID" value="DME_0000129401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848156at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000129401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22651" checksum="1BF80B8866B52A66" modified="2015-12-09" version="1">MLFSLPFQVICQQFSFLDFNFLRQNSGIKLYTKNYLKLKFHTKIFLIQMFQEFPKNNSTIANSDYCDDNEGEEEKQYPIKKFSTSYNLGIAFEDLIKVVINVMKETGIINKKVSDKENPEEILRKKRKMNNEAAARYRRRQKEFREDVELEFENLLNKNESLKKEIKRLKHEVDELKEFLLHEKNPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4B1</accession>
    <name>A0A0N4U4B1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4B1"/>
    <dbReference type="WBParaSite" id="DME_0000161001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000161001-mRNA-1"/>
        <property type="gene ID" value="DME_0000161001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5789697at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000161001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12885" checksum="A183931DE8181B95" modified="2015-12-09" version="1">IFLACTDQFCPEGTFCVERYIVKCRNPPCAPIISCVPDEVKGCKNHEPCPSGEVCVERIVPCIARSCRTIAKCAKIGTCDAMACPPSHKCEMKPKPTCVKTIFSSDDVEQAIRQMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4F8</accession>
    <name>A0A0N4U4F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6027</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4F8"/>
    <dbReference type="STRING" id="318479.A0A0N4U4F8"/>
    <dbReference type="WBParaSite" id="DME_0000166701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000166701-mRNA-1"/>
        <property type="gene ID" value="DME_0000166701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851809at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000166701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44911" checksum="723A49D6B45195A5" modified="2015-12-09" version="1">MKNDLRGNHQWTLAILHAEGFLDEKYYDICAIMDSENSKQKVPFTFRRYLSIIWVDFILANITYGQYSDVDSMKFKWYKPKFGVGEHVCTMMDAKCSKQKLVSVGREDDSINSGCDYALAVVNKKTRKVNLLPTKMINFESCSSNWENLIGDKFPTKRDYSLNFSTDQESRAIKRRALQSEFGSSKLMRAINLSNRRQIKDETLKTMIDSAMVSSLNENSDSKGVQSLTIIERAQGTVLPKANLAAKLPCDVYSLDMFFTELEIDEVEADAVVFFTRSENEILESGFSPLAFKYFNEENKKKKRLCFVLFLDAMINCFKKIGKNFRRHITTEECSNLCYPVKFKEKLMQMFFAGDFRKESARSKSKLFLNATDKDRLLSHLLCLAISLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4T4</accession>
    <name>A0A0N4U4T4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6175</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4T4"/>
    <dbReference type="STRING" id="318479.A0A0N4U4T4"/>
    <dbReference type="WBParaSite" id="DME_0000181501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000181501-mRNA-1"/>
        <property type="gene ID" value="DME_0000181501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000181501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13440" checksum="3EEB37FDC1FDF56E" modified="2015-12-09" version="1">MAALNRPRSEMTQEELQEKEQHEFEVGPLSILTRSVRNNAQVLISCRNNRKLLGRIKAFDRHCNMVLENVQEMYCVPAIKGKGQKKSKSVEKSVNIPKLFLRGDSVILIVQNPSAPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4V8</accession>
    <name>A0A0N4U4V8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6204</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4V8"/>
    <dbReference type="STRING" id="318479.A0A0N4U4V8"/>
    <dbReference type="WBParaSite" id="DME_0000184401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000184401-mRNA-1"/>
        <property type="gene ID" value="DME_0000184401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="1">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000184401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50459" checksum="05824F4081BA6C9C" modified="2015-12-09" version="1">MQFSAVNGVKIYNLSAGKSVPEWLSERKRRKLNHKDIDVRRRIQLIQDFDMPDLSDNITLSPDGRYIFATGSYKPCIKCYDIDNLSLKFSRGLDSDAIKVIILSKDFKKFIILEEERYLEFHAAFGRYFRMRVPKFGRDMAFCSESSDLYIVGNSSEIFRLNLEMGRFLEPLRTSSSSLNRCEFNSHHSLFLCGTVDGRIEAWDPRDVNKAATLDCVAYALAQDAEISTPEISCIKFSGALKMGVGTSTGRVLLYDIRSSKPFLVKDLRTDLPVKNIDFVPHQNLVLSMDNRILKIWEEKNGKPFAAIEPGTILTDFCRYPDSGLMFMANDAPKMLQFFVPSIGVAPKWCSYLESITEELEETEQPAVYDDYKFISKNELESIGLSHLIGTNILRPYMHGYFIDVRLYNKAVILMQPFAYENCKKQKVIAFFLFLSFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4V9</accession>
    <name>A0A0N4U4V9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6205</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4V9"/>
    <dbReference type="STRING" id="318479.A0A0N4U4V9"/>
    <dbReference type="WBParaSite" id="DME_0000184501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000184501-mRNA-1"/>
        <property type="gene ID" value="DME_0000184501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000184501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56097" checksum="A49B7BE7D54B71F6" modified="2016-06-08" version="2">MAKSLPDGNIPTIIVGYNIVDRVGSGAFSKVYKGLSCSSTSNGIRTTVAIKCIDMRTANSSKLSSDCVISEVKILKRLKHKNIVQLYDFQWDKNFIYLIMEYCGGGDLASLISQHGCLPEAITRHFFRQLAAAIQYMYAMNVAHMDLKPQNILLTNRYRPLIKVSDFGLSQYLNHSEFTTSFRGSPLYMAPEIFNYGQYDNRVDLWSSGVILYECLYGRAPFATDSYEKLIDQIKSHEPIKFPTNVLLSFDCMDLLQSLLVRNPNKRIRFENFFAHPFVNLYQGSFSTKELEKADEFIDISSQLERENKIRDAIKYLTSAVQLYMNCLELFDEQNKKSLREKIRANLEHAECLKDRLRPVSDKFLPSTRIFSDCDVWADFPQVRAAVVIAETAHELEMQERWAEALEKYTLAIEGAMRVLTLAKKSQRSVNLQKQVSKWLTNAEHIKTYMDVLDDDVDATSYSNNENLNQRWNFNQLTSKNRQCNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5A6</accession>
    <name>A0A0N4U5A6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6379</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5A6"/>
    <dbReference type="STRING" id="318479.A0A0N4U5A6"/>
    <dbReference type="WBParaSite" id="DME_0000201901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000201901-mRNA-1"/>
        <property type="gene ID" value="DME_0000201901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000201901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12844" checksum="F93878D5DBB4ACE2" modified="2015-12-09" version="1">MNIACQHSRSVRISPEHSITDLEYADDVDNDKSDNLECPSCDSGDSGFSSDDNNCYQELFERNKLVRSKSLRSALRMPTRNRSQKSVRFADVIGLNLVQQSYYEKDDMEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5G1</accession>
    <name>A0A0N4U5G1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 61 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6443</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5G1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5G1"/>
    <dbReference type="WBParaSite" id="DME_0000208301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000208301-mRNA-1"/>
        <property type="gene ID" value="DME_0000208301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000208301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13207" checksum="9A57E0B3185A77A2" modified="2015-12-09" version="1">MEARLVIEIGVTFVKQLEITYNSDILIGMHGSGLTHLLFLPDWATVFEIYNCDDALCYSDLARLRGIKYFTWKNLEKIQQVGRGVSPNTNNENKKFANYRFDRTEFRRLINQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U688</accession>
    <name>A0A0N4U688_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U688"/>
    <dbReference type="STRING" id="318479.A0A0N4U688"/>
    <dbReference type="WBParaSite" id="DME_0000242001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000242001-mRNA-1"/>
        <property type="gene ID" value="DME_0000242001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017693at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000242001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12526" checksum="5F13D87B3144E14C" modified="2015-12-09" version="1">MMVNLPSKLKSAQCLGFIYTSVYVPNDLDVVKSKLAACVNIVPAITSVYEWQGKLEEESELLLIMKTKSSALNMLKEKVISLHPYEVPEFIAAPIEYGSEKYLKWIDTQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U755</accession>
    <name>A0A0N4U755_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS30</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U755"/>
    <dbReference type="STRING" id="318479.A0A0N4U755"/>
    <dbReference type="WBParaSite" id="DME_0000280101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000280101-mRNA-1"/>
        <property type="gene ID" value="DME_0000280101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="1">
        <location>
            <begin position="300"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000280101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="923" mass="103995" checksum="630C30D726F84FA1" modified="2015-12-09" version="1">MPLILPGSLHPSNSNAISWNSNGLLAYGSHCTLVIIDVLSKRIIQTLEKHNAAVNLVCWSPEGEFPTTSDSILRCASVDISGVIVIWDVLDVIEWPQWEETNRDFLLALHSSNIFVLWNTVTGDRVWNVTYSSNLLLFATDLFNMSTVTFGVIDGSLLLINDVLLHKAPSDRGSSIIVLSSPSNLRQIQYHLAYPNILFAASQTEAGNMQLKYERILCCETQRQSTHHRITGVSFCGITQSTLAFLYNSGRIAFYQLALLEDDCFRPYRSRLLNMGEIFSLGQSAHSIRMRHVDGENKLHLAAVGTNQGVIHLVNVFTANIFKEYHIHSCPIKCLEWGGIHTLISAAYSHPLSTSSLVRNDIFVTDIRTGESKRLRPETEETPIEMLRVSFYQCYLAIGFRSEPLEIWHLKSMRLLRRMSRACPVITDMAWSGKHNTIKRIGSSDSVFRENLVVLDQDCHLYHVVVKGLHVRDGKEVNSQWRGGISSLKCLVWKDDYLAMGDAMGRLRVWDLGNRQCRQTSGSLRGPILKMSFSRLNGDHSLAVLHSHCIALWDCDQLSILQILTVGTSLTLLDMDLCGVCPVVLCSDNSFRYIPSVIVNLPVNQFDIPLLVDAIDKDSLFDEVNERFAALFEILDFATDSFTSANIFEKKCKIITDGSFSNFKSESDSDLILSNTDPCLHQSKHLLSGPSSPNFCLKRCRAIHRLLGNKWLYDLLSIIDFKLGAADLSPHLMLFWSGNSSRHRAELLLSCLMNIPNLSSKQIDILVHRAIVLSKREWAMQMLLNSRENCRINALRACLLASDVSSEGAQNGVQMLFLIGHHKDACRYLQIHGMWNLSVYFAKIVMKDCAEVQSKWLENLSARNTQKVLCYFLLACMGEWDRLLTSLTTNSKCKTAWRICNFLQAASIELNESTLQHIQANIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U780</accession>
    <name>A0A0N4U780_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS58</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U780"/>
    <dbReference type="STRING" id="318479.A0A0N4U780"/>
    <dbReference type="WBParaSite" id="DME_0000282901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000282901-mRNA-1"/>
        <property type="gene ID" value="DME_0000282901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000282901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43231" checksum="FFC733D424972C3C" modified="2015-12-09" version="1">MPIWEHVGHALADRNSPVRVAKLDCTRYTNVAAALNIRGYPTVIFFRNGVEMVYDGERKKEALVDFAMKASGPIVSMIDSGEDFSKILHSMNEPFFVYISNGSDSQLFDEYNHAAQTLFSSTRFYHSSSVEFLPSNVSVFSLLPTVVVFKDNSFLVYDHLRDSNLTEWIHCERWSLMPLITSSNIKEVGKFRLLVLSVINMVERKNDSTSVGKFQSVMTKTAALVREDPRLSSFYQFGWLDGNELVNNIILGTMHQPGLVVFNVSSYEYYLSDDIPIEMTVQSLLSFLERILSDDVKARGGRSLQQRIKRIFYEIATNIYDMFKAQPLLTASLFGVPIAFLSLITYCLCSTDFSVDRDEIYPDEDVSDTDGSDYDGHEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7N6</accession>
    <name>A0A0N4U7N6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7165</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7N6"/>
    <dbReference type="WBParaSite" id="DME_0000300601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000300601-mRNA-1"/>
        <property type="gene ID" value="DME_0000300601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000300601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44092" checksum="C7D881FE9D847D29" modified="2015-12-09" version="1">MASTNNLLCAFKSENTSKTCNQGFLSVSKLIEHIARTHMNFSVFICCGCNSTFITALQVMSHVTNCSHPNKAVKVNKDAFISIELLEEIEDLVMRSIGAAIGRAFEKGVEYMRSVSVNRSKYQSGCREYCDERTYQNVQSVPDQIHLPSANTEKEQSDRERKLSNSSQSSDIGTKSIGKELAERMRKKLIADAQRKKRLEQYSEKLKVEPTAVEEKNRKSAVKITSQSRQDMLVEEPKVQQTVSRKLPPTVRYTKLQLTPTEQQTRKTFITSLPKGPSDCENTSKQSHEHNFMNSDNNLPPKSSTGMIRGILKRRLEPKEEEVELAKNFIVSQQPTPENKPSNGVSFSNSISNFTLNMNDLKQEEKSSDSTVANNTDEVDCLALWKILYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8L7</accession>
    <name>A0A0N4U8L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS264</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8L7"/>
    <dbReference type="WBParaSite" id="DME_0000339801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000339801-mRNA-1"/>
        <property type="gene ID" value="DME_0000339801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000339801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20751" checksum="664D57E884918166" modified="2015-12-09" version="1">MADDNIEHDVSDAACKLGIIMQSSYYFMENILRNMSGENVRRLQRVCKNFYLFCEKFRYDNCETLVIWRKRKDTYDWSWSDCDVEGVKDFLKEYSAIPRFIFLFSETTDLSNDLNSILHSSSSFFCGLTENKFKYRNLCRRGRAYFNALKAGINGFILPYGLLNRMDVCIRTKAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8P0</accession>
    <name>A0A0N4U8P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS291</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8P0"/>
    <dbReference type="STRING" id="318479.A0A0N4U8P0"/>
    <dbReference type="WBParaSite" id="DME_0000342501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000342501-mRNA-1"/>
        <property type="gene ID" value="DME_0000342501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257855at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000342501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18718" checksum="B8401C769E7E30B4" modified="2015-12-09" version="1">CSKSDCSTHASCLDCAFFPCNYGEAINVTCSTKNVCSRKYSIKKEAICRYCWQLHSSDYDCTPVKNCTTSSVFLVRTVCHTHQNVICMGRRVFFKNVRCNWSSGYSWWKAMVLSITLGGFGADRFYLGMWKSAIGKLFSFGGLGIWTLVDVILIGVGYIGPADGSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U930</accession>
    <name>A0A0N4U930_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Endoplasmic oxidoreductin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS7579</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U930"/>
    <dbReference type="STRING" id="318479.A0A0N4U930"/>
    <dbReference type="WBParaSite" id="DME_0000357401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000357401-mRNA-1"/>
        <property type="gene ID" value="DME_0000357401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041119706" evidence="19">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="387"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN57606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000357401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51557" checksum="704786C6FFE792DB" modified="2015-12-09" version="1">MVSSLSIFSMLFILILIISANAQFLPHQECFCKAAHAVDSCSCDGSSIDEFNNAFVYTRLQKLLQKDFFRFYKVNMEKGCPFWADNRQCSSKECGIGYCDDEVPSGLKELASIAVVRLSPNRTSIKLTPKQVEEKCEHTSNQFDPLDRTLSDGNRKQLLDMDWHDDNENKFCDIEDDDLSKMHYVDLLRNPERYTGYKGISAQKVWECIYRENCFKPNMKFDKNFLLHPNSDGLCLEKRVFYRLISGFHSSITVSIAANSYKPAIANFDEGRWYRNVDMFRNRFGMKWSWEGPERLKNIYFVYILELRALIKATPYLRKELFYTGNSEEDQATRTAVEELMNILKDFPQPFDESEMFTGVDAFARQLREEFRIHFHNISRIMDCVDCDKCRLWGKVQTHGMGTALKILFSDLPYSHYRQGESYRTPFQLTRFDVPDRKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Q7</accession>
    <name>A0A0N4U9Q7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase A2</fullName>
            <ecNumber evidence="1">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7840</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Q7"/>
    <dbReference type="STRING" id="318479.A0A0N4U9Q7"/>
    <dbReference type="WBParaSite" id="DME_0000383501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000383501-mRNA-1"/>
        <property type="gene ID" value="DME_0000383501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021675at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07212">
        <property type="entry name" value="Pat_PNPLA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="10">
        <location>
            <begin position="647"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="651"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="683"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="814"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000383501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="989" mass="110305" checksum="FC166E906E47759C" modified="2016-06-08" version="2">MQKIDKLTSSDVLTMSAVESIPVDEGELYLSMNDNNIDSNEMVNFKVFSTPSTSDSETNKHCKLPSSTQNRRKQENSPLSSPKHLSPINDKSAFNDVISDQEVPTPPPSPSASRSALQKSSVFSLSQVSVKLFELWSSARERVFGEDYWIPSDVFEVVPVPNEALITHSTVYPIGEKFSCLRVVRGVLKSRSDIPLFHVFFSNNNGSIHSSQNTLSIFRSNDHQEAIDLYQKIDQRKTVCELVNALRLHPLWHIVPVAIATNRIDFFSEKNVKNFQVKHEQYFNTMLHVAIQPEGRYPLMLAIEMHRTEIVRRLLELHADPSSIDINGNNSMHYAALASVQMIELLWEFQSAHSLLNLTNHDGYTPVLLAIRNANPRCVSALISHGAEINIRVAGRTPLFEAMQSKGKSVEVIRTLLQASPNLIKEIEPATGNTVLHAAQFKAPLVGLLHLKHEELDLNARNNAGQAPIHLYASKGDIGLVMTLASYNCDLNIADQSGDTALHMAVSRCDLQMTRLLLCLGADPNLKNKHGDTPRHLASKLRQIDLVKSLAICGAKRCDEDSKTGCVSGCVNTKKLDKIKDSPANLNGSELPTSRSSIYFDDLNGSNKSSITNPISEFKQMFCYDGILQKLEEMALRKESPDFVNLLSLDGGGIRGLVIIQVLIELEKVLGEPCFPYFDMVAGTSTGGIIVAGLAQGRSLRECQKIYLRLKDLIFDSWTRPYNTAQLELFMQNELGTQTTLADIRWPRIMMTTVRADIFPCRLELIRNFRLPLSDEENGKLGYVDPSSISLWKALRRTSAAPTYFASVDNKYIDGGIIANNPTIDLLSELEFWNTAKHYMTLSTANDVKIGCVLSVGTGTIPVVPMDTANLEISSNPYSSAVAIKNLGTILVEQVTATEGVPVERSRAWCHKIGVPFFRLSAPIFKNVAMDSKDDFEIARIMWDCIEYASVMQSEFEKISFLLKKLGHAWHRRHLFETQRIGNDVQTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9X5</accession>
    <name>A0A0N4U9X5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7921</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9X5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9X5"/>
    <dbReference type="WBParaSite" id="DME_0000391601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000391601-mRNA-1"/>
        <property type="gene ID" value="DME_0000391601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823381at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="4">
        <location>
            <begin position="889"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000391601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2153" mass="240832" checksum="FFF765D99C5CB634" modified="2016-06-08" version="2">MEQKNEPIHKIKYFTVICAKNDGGLENIDNDLISAIEEIRKTHSNVTDYLCSLIILNKFSQHNPVNGSRQLMIDDDFLSREKFISSITESDAILLVQLCEMLLRDFSINDKREILLKSLLFTLFWPTFHVRKIANLTLGKVISWYGIEFCKIFLGTMYDYLSSGIADQVLLLMHEKFLQCLCNIILAYLTMFLVEENGSLWSNWLSIIKNLSEILNEDLVSSMVESVFICADARVREYAIKTMISVGSTISFQNAVWNQCENIFSKLDIDRLTSITEKDIGIFKTKDGVLYNTEVIEQNSDETNDTKNVKRENKAYKFKEQILDVQIRKELAEKRRKEGKLTERQKKAVEAELQLEHNIRNELKSLYTLCEEHFLILNAAIRGNPSISVMHTSLLYSVIIPLLKSHLVAQLAFEAFRAFRDATFEPSEDLLHELVLYGSVRIFDSLYCDKAWSQEPLVKQLERTIGLLSARCMVNPVVLLRDEESAVANEQLEGQLELEEETITIAKLCYVFPLIDAIIRHEGMPYVLRSNCIQFLTTALNSRFIKDYEISLLPLSNLCDLLLFVLHAAPSELSQFALSTLITFFELLDGCTSKDAKILAVVQEMLQRLIVDDENFRENVLRALSVCLRIYRFSLTSDIYHEFVKLFNRRIFVAQYDENEFCSKLAKRIWNDAKIVINSPYSLDMCGEVLEEIVSDEQFMRISTSRALQMLIIKFPEQLETSIRKLDELYMKWKEPCGAVIDEVGRMIKEAIDPWKKRLGVAESLLALSGHLAESCVMLFIKVIVPKGLDDRNEQCREIMRNAAVETVKNHGRSKMSELLPFFEKMLDSLSKEKTHDNLRQGLVILLGTLAQYIDQNDGKVRMITGRLIETLSTPSQQVQESVSKCLPPLVPAIKEDAKQLALTLLSLLVDADTYGERRGAAYGVAGLIKGLGMSSLRELDLMKKLQAYLDYKKCAKHREGALLALEILCGTLGKLFEPYIVHIVPALLICFGDNEENVRHAAHDAAREMMAMLSAHGVKLILPSLLIALDTDSWRTKCASVELLGAMSFCAPKQLSACLPSIVPKLLEVLTDSHSRVQKSGEKALKQIANVIRNPEILSISGHLLSGLIDPASKTTSCLQTIINTKFIHYMDAASLALIMPIVRRAFSDRNAETRRMAAQIIANIYSLTDSKDIEPYLCDLVPGLQESLLDPVPEIRTVAAKAFGAIVACSSGSIAERLNDEILPWLKEKLTSRTSSVDRSGAAQGFAEVMKARGDGQLRLIMPEIIDITESTSTTPEVRDGYILLYIYLPMVFEKEFVDYLPKVIPSVLKALADENEYVRESALKAGQRLITMYCSYARRLFLPELQSALFDDNWRIRFASVSLIGDFLFNISGISGKMTSATSSEDDTMGIENVGRIIIRQLDQILAGIYLSRSDVALQVRQAASHVWKVVVANTPRTLKEILKTLFEMLLACLASNSEDQQQMGARCLGELVKKMGERIIIDVLPVLELGLELPSVEQRQGVAIALREIIENTTKDIMAVYSVQLLGPIRKALCDREIAVRKAAAATFSAFYQNIGHSVFDDVVGPLLIALASGTADDGYMLDGLVQIMRLNSRQMLPYVLPKLTRPPINAKALCALASVAGDSLNRNIGRILDSLLATCDENIDRCLEVLLSVSDQESVSLILSTLMQNAFSKNHVPSSLLLYLYVKETKIDLNNFVDDILPGALLLYNSPKNEIIENAVQTLICLSQNLDQKQQVHSLNTLRTALSSLEVQADTNLIPGMSHPKALVPLLPIVREVLLSGASEMKEIAGDVLRNIVKMSSSDTLKPHVVNITGPLIRVLGDRYPPAIKLNILSTLIELFEKVDVLLRPFLPQLQSTFLKALQEPASRNVRLSSGGALSRLIKIHPKPEPIVLELIKLLTVTEDISIAESTLISLRSLINQVHQKLTVEILKSAYNVAEKHMKDSMDDGTIIAAAALYGEAVLKIVHSRLVALHYICSQDAKKVVEIYGLERLRTVLVSAMQFEKAFIASAAVRAAFEILQNIKPIDAVLLTSLVRTINHPSNDVKRLVAVTINHIGLKDLTHAEMKAIVPMMINGTKEKNTAVRAACELALIAVFKMRSKQSVFDDYLLTLEGAAKDVLLDVHKGLVRLAKNADGNLDTVSDIINVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAD3</accession>
    <name>A0A0N4UAD3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS468</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAD3"/>
    <dbReference type="WBParaSite" id="DME_0000410401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000410401-mRNA-1"/>
        <property type="gene ID" value="DME_0000410401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000410401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11566" checksum="858F54978AD30E65" modified="2015-12-09" version="1">MTRGTVKWQDSNGVLIKNIKNRLIRWKEFFEAKLNHESIAPNVTDTFAEAYACEPPTEEKIISIIHKLKANETPGEDGLRALNSSNFIHRPAKRIFNKCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAM2</accession>
    <name>A0A0N4UAM2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8092</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAM2"/>
    <dbReference type="STRING" id="318479.A0A0N4UAM2"/>
    <dbReference type="WBParaSite" id="DME_0000420901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000420901-mRNA-1"/>
        <property type="gene ID" value="DME_0000420901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196957at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="4">
        <location>
            <begin position="78"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000420901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33921" checksum="B04EC70224638A89" modified="2015-12-09" version="1">MSEPLSLMYGIDQQTRCIVGVHAEQERTLFLAGTLSIKQDNQLCVLEVDDDWLQISKRSFAHPFEFHPDGQKAAVVFDKTLNFMDINDSLETVHSMQIACKGSINAISWNPHSNGSLISVAYDDFIKGIDYRSLDSAFIIESVNTPNVRNLDYNPNVQYILATCGDDCKVSIWDTRKVMEPLKSLHDHSHWVWSVRFNPIHDQLLLSVGSDARIFLNNLESLSSESMHALDFVNDDAENTRVPKLEDGRLEKLEEHEESVYSCAWATNDPWVFATLSLDGRVVISRVKRHHKYAILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAW6</accession>
    <name>A0A0N4UAW6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8202</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAW6"/>
    <dbReference type="STRING" id="318479.A0A0N4UAW6"/>
    <dbReference type="WBParaSite" id="DME_0000431901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000431901-mRNA-1"/>
        <property type="gene ID" value="DME_0000431901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19773">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19774">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000431901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="63364" checksum="64D4D8F5939D4777" modified="2016-06-08" version="2">MEISGLECGLCHEEYGNSGRRIPRMLHGCGHTICEQCCFALCGQAISTQLICPFDRIASNLPDLNPESLKKNFALLEVIERIRKEQSRKSPPTFPLNADSQMKDLLLGIPCDEDSTHTALYFCLVCESHLCAECSTGTHKSRVLSKHNRVPVSEKPVSRPMCPFHSAYALEFVCQEVECLSESRLMCLLCRDYGRHQRHRHSLLDVEAFELRKRVKEALSDFRKFMSDLNSWNSRVTQSVTEILDPNEGSHAAAKRQVEGHFRRLRSELDTQEQVALARLDAHVADRVDILRAHQQELAIITSQVSSISAQLQKSADMDDARLIEQQADLIRMLDAVRSHQHNMASAPIGISLDTRIPFSFTADNKIHMGSNVDIRLVILGLDGAGKTTILFKLKNDDYRQATPTIGFNVETLQYKNFKLTIWDVGGLPKLRPLWKHYYLNTQALVFVIDSSCPSRFLEAQSELVRILAERDLVDASFLIILNRRRIPGNESCEIDSAAIDQLVMNINRFSNGRSVLIHQCNALTGIGLWEALDSLTSNLLLTRNQNELLETNVQDSIRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB36</accession>
    <name>A0A0N4UB36_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8279</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB36"/>
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        <property type="protein sequence ID" value="DME_0000439601-mRNA-1"/>
        <property type="gene ID" value="DME_0000439601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000439601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22473" checksum="5E8447B01365DD0B" modified="2016-06-08" version="2">MGSTHSRQTNAGRPRQRNKNCWPFAINEENNPGSSTCEKSTSFINDEKCKSAKIAAATAAAGDCSISPNKTEGRNRPPSLALNEPSTSLLPSLSPTSSTTSSDSTAFYYTTNEMLLQIIRCFPFPSPKSSPLPSPSSTHRNLERALSMNSEIKEKQYKKSNRSKSISEAKKTKCLAGMSSNNSPQSKTPSSENKTGDSGSGVVEKLAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBY4</accession>
    <name>A0A0N4UBY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8626</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UBY4"/>
    <dbReference type="WBParaSite" id="DME_0000474301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000474301-mRNA-1"/>
        <property type="gene ID" value="DME_0000474301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000474301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23075" checksum="96E942A27AEE50E5" modified="2015-12-09" version="1">MWKSTIFRFCGRSLVSSIQRRAEPLPANSVKYSKASGNEEVGTENEVNGNDELDVDKMLAKAARRAPYSSEALAELNFNKYPYYIEREWWKSGKRMTFWATWRMLRDVRRREALAAVGPDLFRLKAMKLNTILPQAIRDECADKIYSFGDKPHPRRILNLCQFTGARRGKLKNFRLSRHIIRHLADFGKLSGVQRSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCE5</accession>
    <name>A0A0N4UCE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS557</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCE5"/>
    <dbReference type="WBParaSite" id="DME_0000493601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000493601-mRNA-1"/>
        <property type="gene ID" value="DME_0000493601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000493601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8499" checksum="EC018A59A3687F93" modified="2015-12-09" version="1">MKVQILASNEICVKSYGGRRRTCSKNQEIPGTLEISIQRSIQRSTLPGTAKILHRSLNLSGLGRRLEDGRSCDTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCM4</accession>
    <name>A0A0N4UCM4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8823</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCM4"/>
    <dbReference type="STRING" id="318479.A0A0N4UCM4"/>
    <dbReference type="WBParaSite" id="DME_0000502401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000502401-mRNA-1"/>
        <property type="gene ID" value="DME_0000502401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720917" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000502401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14007" checksum="BC7E8BA1BE9FA469" modified="2015-12-09" version="1">MLEVVSYILIIYLTFASIPYFSTANDVDQMNCDNENMGDFMRFGILLSHNDLRSNLSRGIYDFPSGSNMYRIRYDCQLEKLAQQRANNECSISNISDHLADTIGENIYRYRSNNSNSDSSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCU4</accession>
    <name>A0A0N4UCU4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8907</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCU4"/>
    <dbReference type="WBParaSite" id="DME_0000510801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000510801-mRNA-1"/>
        <property type="gene ID" value="DME_0000510801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870094at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000510801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23183" checksum="809CCA5E651750CE" modified="2015-12-09" version="1">MAKKYKSSLEEVELEMRKTLKKFRSTDWTDKVAAINMILCISEISPCICEKYSNRIFDRLVEECKDIRTALSRTAIFATGQLFSNVKVCLTLLQKTGDVSHAFIRRSAYDALNEIIKNASTATMDVLAALLDVTVITSKNNAIRASCASLVVKLVKRIGPSQAIKCSEASKLLSALVAFAQDADPNARNDGRRGLFLLNQGDDGNSKGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCX6</accession>
    <name>A0A0N4UCX6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8941</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCX6"/>
    <dbReference type="STRING" id="318479.A0A0N4UCX6"/>
    <dbReference type="WBParaSite" id="DME_0000514201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000514201-mRNA-1"/>
        <property type="gene ID" value="DME_0000514201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790186at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000514201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13347" checksum="2FF538FA79CF593E" modified="2015-12-09" version="1">MITGGSSGGRTRPPPFGGRSPQSSFDSNGDVGQISVNLMLVNGGITPFKSLLTSYNSPAAGLKSSSSTHLCRVASLKKQSNTLHHTYDINRWKGSGTKLASEAPALAIEVDAPRAPDLNQTINYFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD09</accession>
    <name>A0A0N4UD09_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8981</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD09"/>
    <dbReference type="STRING" id="318479.A0A0N4UD09"/>
    <dbReference type="WBParaSite" id="DME_0000518201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000518201-mRNA-1"/>
        <property type="gene ID" value="DME_0000518201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5814573at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000518201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31248" checksum="6145B2BC9AD6C727" modified="2015-12-09" version="1">MEAYKTRSNSRNSAGQIHNSDSNQRRHSLTAQLTRSARRFSAAFVPQFTKLDPIPILQKYLCLKIRIIDIRQLQVAVERYVINNAVHFNPIEFEVVDENDSHIFEISLYPEEMVLNEGTKRILSLTFAETDSDDDGIVISRIKHPLSGMRVFEFVERPCSDLIHISSYIDQFDRCYIEPVTNSWLRLLMICGCLFTQVQWHFKREDKIFAVVRPNKTFLGENSFKLEWNEQANNELRVIVIAFAMTQMIREAFPSLIHILKEHRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDR1</accession>
    <name>A0A0N4UDR1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS588</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDR1"/>
    <dbReference type="STRING" id="318479.A0A0N4UDR1"/>
    <dbReference type="WBParaSite" id="DME_0000548201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000548201-mRNA-1"/>
        <property type="gene ID" value="DME_0000548201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10034757at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18318">
        <property type="entry name" value="BTB_POZ_KCTD20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF0">
        <property type="entry name" value="AT10158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000548201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43307" checksum="417521A632C3574A" modified="2015-12-09" version="1">MSLGSASHESLMASNTSSRKVSRTIDISRAANGDKVTLLIENTRFIVDPAVLIAKPDTMLGRMFSVRNQYEGVELVQPNERNEYEVAEGLSSACFQAILEYYHTGKMRCPPSVSASELREACDYLLIPFNANTVQCYNLRSFLHELSNEGARQQFSLFLDDIILPQMVASTEHGDRESHIVVLLDDDVVDWDEHYPPQMGEDTTQVVYSTHLYRFFKYAENRDVAKQVLKERGLKKIRLGMEGYPTHKEKVKRRFNKAEAFTFIQTYIILYFIFCYSFIYLYVLHSYCVIYLVIYNYVQRPFLHCSWEKEEARSRHVDFACPIVKSKSNPSLASAASDPLPQRLQPLHSPPVHMVRYSAEMHPNQSNFSGDTATSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEE1</accession>
    <name>A0A0N4UEE1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9335</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEE1"/>
    <dbReference type="STRING" id="318479.A0A0N4UEE1"/>
    <dbReference type="WBParaSite" id="DME_0000574201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000574201-mRNA-1"/>
        <property type="gene ID" value="DME_0000574201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000574201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27254" checksum="A1CDEA2AD1958DA6" modified="2015-12-09" version="1">MENITKDDESNGIDIFDELSPNTLLALCKFYMQREENFNDNNLMENWQASFSYFWLSQFWYSDETVQKFSNECSSIVKENGHVACVCCPSLLPAILANEIFKKKCASVKLFEFDERFASKYPREFIHYDYRVPLTIERCYHGIFDVILVDPPFLSEECFINIAQTVKLLKHDINAKILVSTGIVMESLVRFFMYILFQVKQLYNTIRSSFVPTHASKIANEFACFTNYPTQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEP2</accession>
    <name>A0A0N4UEP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9379</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEP2"/>
    <dbReference type="STRING" id="318479.A0A0N4UEP2"/>
    <dbReference type="WBParaSite" id="DME_0000585501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000585501-mRNA-1"/>
        <property type="gene ID" value="DME_0000585501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847388at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000585501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="58591" checksum="C269D90DAA495D30" modified="2015-12-09" version="1">MATAILHTNDMHKEQSPTAMCSATNSPLLHGYSPNQQLANYGNATLPENIYTSQQSQQQQQQHYSVQQQSRNIYQNLTPEPVGPCSGLESTSFVELGAVNQQQQQQHRVTVQVETLTIHDPFEEIPRKRPCNFQRPPPYINTGNPLHSGLQLDLPRFASVTYPDTAYEATVVVNKAFINMAATNGICLQRRISHNSTASPQMRNNNANPYQNHMPNGLTSNYPPLTPPPSNGMQPPHPYMPTAQIRHMKIAMPPQASTYPYCPPTIAVPSVKKSITNAKRVKSQQLKNLDDLPAKAVRKSDFCSQPITSIYDQVNTDHGPSTSGTNPSCAAPIMPCGAINMIDRQSPSCLQNPQIHLHNMRQAYSFENGNVNSIPVQLNVNSPSAELIQQSHLSTMRTNGYNHITRGDTGDGVALTKQEIANHGYSMAPEVIADIRPYDPSLLAMKSPLYQASSNGGASGIYATKNGNINNSPINVQQCANERRGIQCNGNGLGCKRIFHQECAQLAPEAFRMVLSEPNACWICDECASRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF14</accession>
    <name>A0A0N4UF14_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS940</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF14"/>
    <dbReference type="STRING" id="318479.A0A0N4UF14"/>
    <dbReference type="WBParaSite" id="DME_0000600101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000600101-mRNA-1"/>
        <property type="gene ID" value="DME_0000600101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000600101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8211" checksum="A5D8A36E1F5F479C" modified="2015-12-09" version="1">MPVPQSHLSTGQPTCWQKLKLGFMMGAVIGGATGVVLGSFGAYKMGLRGKEFLTQVGKIAAQSGGSFGVFMMVAQGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFE1</accession>
    <name>A0A0N4UFE1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein kinase C</fullName>
            <ecNumber evidence="20">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">DME_LOCUS9443</name>
    </gene>
    <organism evidence="29 31">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28 30" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interaction with par-3 required for the peripheral localization of par-6 and to form a par-3/par-6/pkc-3 complex, which is activated when cdc-42 interacts with par-6. Binds avidly to the phosphotyrosine interaction domain (PID) of a novel pkc-3 adapter protein num-1, which enables tethering and targeting of pkc-3 to the cell periphery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="20"/>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFE1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFE1"/>
    <dbReference type="WBParaSite" id="DME_0000614701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000614701-mRNA-1"/>
        <property type="gene ID" value="DME_0000614701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007506">
        <property type="term" value="P:gonadal mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20794">
        <property type="entry name" value="C1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000071">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000012">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012233">
        <property type="entry name" value="PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000554">
        <property type="entry name" value="PKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15" id="KW-0278">Fertilization</keyword>
    <keyword evidence="14" id="KW-0306">Gastrulation</keyword>
    <keyword evidence="12" id="KW-0334">Gonadal differentiation</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="27">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="25">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="256"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="26">
        <location>
            <begin position="533"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="262"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="VDN59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="WBParaSite" id="DME_0000614701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="606" mass="68772" checksum="994C49C72E648BEA" modified="2015-12-09" version="1">MLSTPKISFIEETDVKLKTRFQGQVLVLYAKVPLLLDSLLSSLREACKQSSSQPITVKWIDDEGDPCTISSQRELDEAIRLLNMNGDAELNVHVFLGVPALPGLPCSGEDKTVYRRGARRWKKFYHVNGHRFQAKRLNRRMQCFFCNDYIWGLGRQGYRCADCRLCVHKKCHRAVRQPCGDHSFGSTTTPSPSVAYIAPRINGSGGLNVGFDNCAFKESEIEADHSLKRGHMGNDYHMVISNLGQESKPAVSLDDFNLLTVIGRGSYAKVVQAEHKKTKAVYAIKIIKKQMFNDDEDIDWVQTEKSVFETASNHPFLVGLHSCFQTDSRLFFVIEFVPGGDLMFHMQRQRKLPEDHARFYSAEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIGPNGVTSTFCGTPNYIAPEILRGEDYGSFINGFSVDWWALGVLMYEMMAGRSPFDVVGMVNEVDQNTEDYLFQIILEKQIRIPRSLSVKAATILKGFLNKEPTERLGCCSDIDEALDDMKTHPFFRNNIDWELLEARQVTPPYNPSVSSDRDLQHFDTTFTDEAPALTPDDPQVIERIDQSEFEGFEYINPLLMSKEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFI6</accession>
    <name>A0A0N4UFI6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cse1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1099</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFI6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFI6"/>
    <dbReference type="WBParaSite" id="DME_0000620201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000620201-mRNA-1"/>
        <property type="gene ID" value="DME_0000620201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="1">
        <location>
            <begin position="67"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000620201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40534" checksum="261F705D3F83B685" modified="2015-12-09" version="1">MQIRAQLLDFMFKAPANIRLQLSEIVCVMSKYDFPDCWPELLNLLKEILTMNDANRLLAALTTMDELFKRYRHEMKSEKLWNEIYIVLKELAPPLTILFTNVLQYVSTESVEKTKEKYDEMLNILHLIMEIFHSLNVQDLPEHFEDTISGWMEGLGTILKLKIDSVESAYSDDEPGTLDKLKCCVCDILTLYSQRYEEEFMPFINVVIEIVWEQLMGLDARVSINKFRFDAFFTSALTFLSAICVKQRYANIFQMDGVLTSITENIILKNLVTRPTDLEQFEDEPLEYIKKDLEGKECSNDLQQNWLKKDLVYCLILAVGAKTETVKFGATTLSNFVSHFLNFLNESVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG66</accession>
    <name>A0A0N4UG66_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9578</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG66"/>
    <dbReference type="STRING" id="318479.A0A0N4UG66"/>
    <dbReference type="WBParaSite" id="DME_0000646701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000646701-mRNA-1"/>
        <property type="gene ID" value="DME_0000646701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000038">
        <property type="entry name" value="Glutamate-gated chloride channel alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000646701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="554" mass="63921" checksum="19B10141B7320EE7" modified="2015-12-09" version="1">MSHLILESEKYTGGPVLVSVNIYLRSISKIDDVNMEYSAQFTFREEWRDARLAYEHFADENTQVPPFVILATSEQADSTQQIWMPDTFFQNEKEARRHLIDKPNVLIRIHQNGQILYSVRLSLVLSCPMSLEYYPLDRQTCLIDLASYAYTTDDIKYEWKLTNPIQQKEGLRQSLPSFELQDVLTDYCTSKTNTGEYSCLRTKMILRREFSYYLLQLYIPSFMLVIVSWVSFWLDKDSVPARVTLGVTTLLTMTTQSSGINAKLPPVSYTKAIDVWIGVCLAFIFGALLEFALVNYAARKDMTTGQRMPKHYPLTEYSSSYQPLVATNSRSFCCFHLFVRRYKERSKRIDVVSRLVFPIGYACFNALHSVHYASRRFMGFILAGQVPARVSLGVTTLLTMTTQASGINSKLPPVSYIKAVDVWIGVCLAFIFGALLEYALVNYHGRKEFLRKEKKEKNTKYHDCLCAPSQTLPQIGFPSMRLDMSLYRKRKWWHSTSVFRSWFGATSDVSKRVDLISRFTFPTFFVYRYVIALQTVANDNSVVMMFEPIGNYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI29</accession>
    <name>A0A0N4UI29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI29"/>
    <dbReference type="WBParaSite" id="DME_0000724201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000724201-mRNA-1"/>
        <property type="gene ID" value="DME_0000724201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000724201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18699" checksum="5FD90F35F707BF5A" modified="2015-12-09" version="1">MNKAENFTSESGSYPSFLANLDNTKAERQLINAGKRGGARTFGPHRFDFDSFFYPTDKRQETFSPYYFYQQPKRGGGRGFYSVWNPPTISESRNLPFILTSPIIIYKSGFPLIWDRMSFEDKIIGPTAPFEFHRLFDILKAMMLNLNLANKFLTILSPTRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIE2</accession>
    <name>A0A0N4UIE2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1731</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIE2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIE2"/>
    <dbReference type="WBParaSite" id="DME_0000736901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000736901-mRNA-1"/>
        <property type="gene ID" value="DME_0000736901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="35"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000736901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43057" checksum="20312B6C4BCF95F7" modified="2015-12-09" version="1">MNAIEKTIRKRSPEPDLIDRNYEKKKNGGEVACYKIIMMIGLYYPLSIGLTFYQKWFIKSYKLPLLIVAGHYLLKFFMAIIIRWVFEIFKEKRIRISFYEQCRWLVPIGICASLDIGLSNWALEYITVSLYTMAKSSCILFIVAFSLFLRLERWKPILGVSATLIAVGLFLFTWRSTQLDVRGLLLIELAAACTGVRWTFSQLIMQREDQAIRHPLDMVVHVQPWMFLTVLPLLFVFEGSELSYQSVFYYRGVFAPYQIFLYILVGGVLAFALEISEYFLLVFTSGITLNIFGIIKEVVTLLLAHFINGDRLTMINIFGLLLCLSGMSLHGASNRHKSKRRLSFSKDRNSLDCQSLLAVVSLALFSKPFKNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIW6</accession>
    <name>A0A0N4UIW6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIW6"/>
    <dbReference type="WBParaSite" id="DME_0000756801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000756801-mRNA-1"/>
        <property type="gene ID" value="DME_0000756801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794420at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000756801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20499" checksum="7CB1434FF5B584A5" modified="2015-12-09" version="1">MFENIARLFLIFQYFSGYLRLNNAFEPISYEIKSCQTAIPGDCNPYSCQGTCEGRYLRFWDSYLKLDRTSKSCQCVQEPICSLVGMNAYAGCRSYDHLPENAQRIIRMWSMSNKDTLRKFLKPRFRQYFHKLRHSQLLHGNSRFCCKTIQSKSARIHSYQSFILFILYFNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIX7</accession>
    <name>A0A0N4UIX7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1847</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIX7"/>
    <dbReference type="STRING" id="318479.A0A0N4UIX7"/>
    <dbReference type="WBParaSite" id="DME_0000758001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000758001-mRNA-1"/>
        <property type="gene ID" value="DME_0000758001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="267"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="343"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000758001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="670" mass="74896" checksum="E5AEAC7B26C5E6FA" modified="2015-12-09" version="1">MLDNDIGALLDWSVLEPGSSKPSESDRKTVVVEVGGMKCLACVNNIQDNVGVKDGIYNVNVSLEKCEAVIEFDSGKWKVDDVMNMVSGMEFDAKLKYISGIWLSLDVSLLIDKADSILKEIVLQIDGMTCHSCVNNIEETVGRNDGIQSISVSLNLSEGKIVFDSSKWSKETVVELVENMGYDVKVLSVNGLFFLQQLLYILLLYYYYDNSKVLSSCTNSSEKYSNLQSVLRKKKIDDLEEINLNLEKEVVQKKSAKFRSLVDDNIDKCTLSVEGMTCTSCVAYIERNIGKLNGINSVTVALMASKAEITYDSNLIGISEIIQKISALGYHSELIDNGFSNHSKITLKINGMSSSNCSSRVESHIIARKGIESCSISLATSLASVEYTPAFIGPRDIIKIIEDLGYSATLVNRDDRVKYLDHSEEVAKWMKSFRISLIFGIPVMIIMVYFHWLHHTHSNPSHQIPIFFPAISLDNLLLLILSTPIQIIGGRYFYEQSWKALRHRAANMDVLIVLATTISYLYSVFVLLFAIVLKWNSSPMTFFDVPPMLIVFVSLGRWLEHKAKGKTSEALSKLMSLQAKEALLVTRDNQGRILSEKGIDIELVQRGDLVKVVPGSKIPIDGIVVDGKSTVDESFITGESMPVIRREGIRPCYFYLNKFDLRSPKSTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIZ5</accession>
    <name>A0A0N4UIZ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1866</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000035">
        <property type="protein sequence ID" value="VDN51893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIZ5"/>
    <dbReference type="WBParaSite" id="DME_0000759901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000759901-mRNA-1"/>
        <property type="gene ID" value="DME_0000759901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000759901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10977" checksum="3251F3B40AFF4934" modified="2015-12-09" version="1">MGISNIFTILLYIIPIIVQLLYDLITHDNPDYIVLYSSVSTNLNPLANIAILVLRQNDIKESLMKKFPVFQRTIRISAKVAPPKFAPSKPAKENTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ36</accession>
    <name>A0A0N4UJ36_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1916</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ36"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ36"/>
    <dbReference type="WBParaSite" id="DME_0000764901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000764901-mRNA-1"/>
        <property type="gene ID" value="DME_0000764901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF175">
        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="6">
        <location>
            <begin position="598"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000764901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="748" mass="84025" checksum="D26173E992AB63EB" modified="2015-12-09" version="1">MKPSYEAIVPDTITSWVASAFAISDQSGLGVAPSTSKLTVFRPFFIRLNLPYSVKRGEKFALQILVFNYMDAEQDVIDFNCMKYFSKDTKDKNYNMRMISVPSGGISKAVYFPIVPTRIGEIFLSIVAQSAKAGDAVEQILKVEPEGYRVDRNVPIIIDFSKKSINSSAEFEKTIDLQFPKDAVEGSRRARLDIIGDIMGPVLSNIDSLVKMPFGCGEQNMINFVPNIVVLRYLRAIQSNVQIEAKAVKFMETGYQRELTYRRDDHSFSAFGQNDKHGSTWLTAFVIRSFKQAQPFIFVDDHILQKSIAFLNAQQQQENGAFAERGEVHHKSLQGGAAEGGIPLTAYVLISLLENGVKNAKALYYLEQHLEEIKDDPYALAIVSYALHLTDSTKKAVSLKMLEAHKINDTDGSVHWSAKISTSNKKKDTQQYFYLPNPVDVEMTAYALLTYMLTNDIDNSVPIVKWLTSQRNSFGGFSSTQDTVMALQALGTYAERAYSPVLNFSVILNNGADKHQFEVKPENAIVLQSYDLVNLDDEVKLHANGNGIIFAQIQYSYYRVALKDDLPFYCTKDIRELYGGYRLQLDLCCNYTRLGSRSNMAVAEITALTGYRFDADEASRLTDIANLQRSELDNDDTKMNLYFNPLGSTPVCLSLYSDMVYQVADLKPAQMALFDYYDPEQQVKITYNAKQMRSLQESCPDCWPSVETERITDIVSLQSLSGANSSRSGLILFALIAIILRMPIIVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJH5</accession>
    <name>A0A0N4UJH5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Autotransporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10183</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJH5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJH5"/>
    <dbReference type="WBParaSite" id="DME_0000781301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000781301-mRNA-1"/>
        <property type="gene ID" value="DME_0000781301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5878048at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000781301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1284" mass="145704" checksum="FB523566BB427BB5" modified="2015-12-09" version="1">MLNNNCYCIIFTLLPYIYIFFSASVLTKIKNNSQLFSTKFSFESIIRSASEPISGQTLSVTPAYNVESKIYNTKSTNNTKKEATRSNSTNDQFKTSRNSKKDAPSTKEISTQEKIKSPSKPKISAKKYTGKYTVKPSIHNTIKESDEWFPKIDNPNTFIQTRISEDSGLYATDSGKVEYIESNATIIQTKRILGNHSNMNFDINLENTIYRNSGNSKNSRTITEKSILKNYPTKFETDFVAKSSIYGNIHNNTSNTPAIADEYTLKGALNYYRRQLDVTLKVNSDNPLSIFSSINSESSLVVNENLTTIHASTSSNRMMDTSLDEDKNRTARVDTSPLKNNSLIQTSLANPTVNYLQQSSNIAKNNSIDIKAIGILSSVNSPFITNYFRTNNSNSSEFGSETQIYTISETTIGDEFKNKNQNNEKIKFSITKNPLITGTAIFLETKYSDTNSMEELESTIMGNDGEMELKRAEGTTNQQSSSISVGTSKTIIQFNNSKIADISIFSDSNLNNQREIPNYSSQKDTIDFHKYYPNSEANILSKTTAILSTNWHNSTNFGKTFQNVSDKTNFPFTANLLNDESVSLSLSQLNNAGLNKSVIGRSISISPVSETTGNKSASSIYRPNTVDNSSQNEFSDEKVIRTNSDFIWNDQKVTNEYFNEYASNKTNQYAFSSGSTIQQIWRTIASNETSGFNPLASNNLLITLVLGSETKRPPHLSSQLDNNNRTRSFFRSPTFSHKLSNNNYVMLNPTNDTFLNFIEIPPENMSTILYERFGSLNKLKTIFGSKIMYNKPKSPFTSNILISLRKKSTRIYDKNEIRQSNAKSFITTSEFKNNLVKNEKQYSMKLSKSAKGKDKQELQELIYTTKRYNDKTRYNDKTWINNITMNNNSNVPNDSTNKLKITDLDKYISLMIATSGKSRFSASFNKIPITKNSFTKSAFLKLADNENLKSFNITSSGNKKSTIPKYLIISKKTNIEEAIYHQSMERNNDSRSRIRNFDVMKKYSNIFNNSTIKLKTTEVHKYSQFNLTTAKRPQLYFSENSPIKFVSLKFIANNNSKSMNIINNGCKRKLNLVCNRTAKRYGNNRPYDNITQNTIKNSILTKKNSSTINDDTLSVISNALKIINHDMMNESTKTYQKNLTIRPNSSTIKTNVDDKMMMKLIVNPSDLKKNANITSRSKFILSISFILYFILYFQSYIFKDMHWVNGKVFSFPPTIAIDKNRDQTRLSPYDDPGLLSRQPVGKLIVHVCQHDFLFASTKQPVNIYECMDDGHWSSNMLGETCKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKU7</accession>
    <name>A0A0N4UKU7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS2387</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKU7"/>
    <dbReference type="STRING" id="318479.A0A0N4UKU7"/>
    <dbReference type="WBParaSite" id="DME_0000838101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000838101-mRNA-1"/>
        <property type="gene ID" value="DME_0000838101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002164">
        <property type="term" value="P:larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000181">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000838101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44828" checksum="100C5A583C3AC750" modified="2015-12-09" version="1">MTTVEEVQTRNAVEEVHGQIFEVGPRYINLSYIGEGAYGMVVSALDTETHERVAIKKISPFEHQTFCQRTLREIKILTRFKHENIINIQEIIRAPSVEQMKDIFQFFFSFNELNFLIFSYIVQCLMETDLYKLLKTQKLSNDHICYFLYQILRGLKYIHSANVIHRDLKPSNLLLNTTCDLKICDFGLARITDPIHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLNNRPLFPGKHYLDQLNLILAVIGSPSQEDLQCIINEKARSYLLSLPHKVKQPWLRMYPSADPRALDLLDKMLTFNPNKRINIEDALAHPYLEQYYDPNDEPVCEEPFTLEMELDDLPKETLKALIFEETENHYKRTQEAKLHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULH3</accession>
    <name>A0A0N4ULH3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS2563</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULH3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULH3"/>
    <dbReference type="WBParaSite" id="DME_0000864801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000864801-mRNA-1"/>
        <property type="gene ID" value="DME_0000864801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="13">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN52590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000864801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="50611" checksum="9500661569D7F9C9" modified="2015-12-09" version="1">MERCSFILPKKKRRCKMLVKKGNKFCGEHFIFDENNVERIPCPNDPKHTVNRNELEDHLNNRCNSRLRIDYPWIVENCNFDLRNENMEDFLKLQLNERDLIRMVKIIHKICEDLQLSGLIQKSFLETPIIQKFMDESREMSATRRKHLAQYSSIIGCLKYSKLLFDDDDCCLIELGAGKAHLSYWLTKIVPKYTFLLIDRMGMRNKFDNKALKENPQLKLVRLRCSVEHLDLSRISFVKVFFPFTAFNFFIKKYIYILFFLNSCCVTAICKHFCGNATDYGIRCLLNGFQKGVKLKGFVLAPCCHHKSLYNQYFGKDYLKNYGINSSYQFAALRHIASWSTCGMIHPCQDMEVNTSSNNFTVPNFSNISYLWTKEQKEEFGFQAKMVLEMGRVLELQKYGFEVNLHKYIDCSISPENLLIIGRRCEISENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULN6</accession>
    <name>A0A0N4ULN6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10450</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULN6"/>
    <dbReference type="STRING" id="318479.A0A0N4ULN6"/>
    <dbReference type="WBParaSite" id="DME_0000871701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000871701-mRNA-1"/>
        <property type="gene ID" value="DME_0000871701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000871701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25950" checksum="046D5650BDF0425C" modified="2015-12-09" version="1">MQKAKEIMLQKKEEKEKVRKMSESKWQPSRLLGCTRPPSVNFFTEDSVGSECSCILSGESDKKLVDSDKEEDLSSRRQIMGSRTNSLPQHVNSSSDLKSFDSEIFNENDEKIQQNYEAKIGHHLASSPFENLQYPIEIKERTNAMERQFYDRSRMEQFGMHFNLNIVPYEVDTLEEFRTKSPHQIEIYAFRDTTDVNYQRMAFTGEELSGVSTFSKNLVLFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT0</accession>
    <name>A0A0N4ULT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2659</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULT0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULT0"/>
    <dbReference type="WBParaSite" id="DME_0000876801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000876801-mRNA-1"/>
        <property type="gene ID" value="DME_0000876801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877528at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000876801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="816" mass="92412" checksum="A0B3219689420C16" modified="2015-12-09" version="1">MTSLVLSKLYRHALYNFYFPSLIGQKEIYFLSTSKRRFSKVSVNNDNIDNLNNNESETISKEQILDVEKLDGISDSDLQLFINNLLQQDENRSNENSNENTKENLKNGGEKDSKISERKTVRTVNDKILKKNIVRIFNDKKSGKNVVGIIGDKALKKNIVGSFNDKISETSVVKTISDKASKKNIVGSFNHKVPETSIIKAISDKASKKNITEASCDNISEEIRNEHLDLFINKQTDSVKNEMQHFTSKQNNEKGNLSKFLNIAMNTKSLEILQKILIKEKQHLNAEICSLSLERLAALAFLQNRTSECKIWFEMNLMEHFDKIYSTEDVNLKFIIIAVNSLVNIGLHETHLCKHLLKLIDERYNSSFSSVPIAIRIKFLKLVKADKAFIDISKNLSATIERSVFLQMNEIKNASSLLTLLLNVPLTDLQLKGVLERSKQFLSKMSCGELISILSNLSERKLWHVDIIPLIVAALQLNTSTLTANQISNLSHAVVALNYFDNRLLHRIATDITKKICNVTSWSTVSNILASFCKFRFIDEAAVNVLVDWINTKYELATDTELSFALTAAVNYGIGDRILNALQFSAKIASIESAKSPSIWLNRIHALAMGKALTSRLAETVLRMDFVSHLLQETNPPKKLLLLTKLAQIQCSALCELSDFRGQTLELFDMLKLYGKEVALEMKYGRKKIYDAQCFHDLLYKLAPLDTHAFAPAVNEDGIFIDAILKMDMNERFVPINKFSDIPEPPIAIVYLANKHLMFEKFAIPRPLFTFCLRLLTVKGSKAVIFTEPEIKAHTTFTGKLNFIRKKISVVSNQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM10</accession>
    <name>A0A0N4UM10_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2721</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000076">
        <property type="protein sequence ID" value="VDN52748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM10"/>
    <dbReference type="WBParaSite" id="DME_0000886101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000886101-mRNA-1"/>
        <property type="gene ID" value="DME_0000886101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798700at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608">
        <property type="entry name" value="PROTEIN CBG07207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608:SF3">
        <property type="entry name" value="TNP_DDE_DOM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000886101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13964" checksum="C64B864301BC39DB" modified="2015-12-09" version="1">MIHVFNSPVECSTMSEFQKSKDSNDLFDGNNLNKRKITYYKDGRKMVDGKIEVEQNPTDLWTSALTRSVANEFKGLSNLKLFSVAYLNNAYRMQPKKFYIYILLAINALLLLIAFCCKIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM90</accession>
    <name>A0A0N4UM90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NTP_transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2781</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM90"/>
    <dbReference type="STRING" id="318479.A0A0N4UM90"/>
    <dbReference type="WBParaSite" id="DME_0000895201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000895201-mRNA-1"/>
        <property type="gene ID" value="DME_0000895201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000895201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="44901" checksum="3117B4D34F7FFAEB" modified="2015-12-09" version="1">MSLKAAVLVGGAWKGTRFRPLSLQLPKPLFPIAGVPLIEHHIEQLSKLTSLTEIFLIGFYPARQFDEFIYDCEAKYSIKIRYLEESEALGTAAGLHYFRKEILHDNPSAIFVLNADVCGDLPVSEMVVELERKPDAQCLLLTSEATREQSVNFGCVVIDVDGKVLHYVDKPTTFVSQHISCGVYLLRKEVIDRIGKALKNSETRQVWFETEIFPQMAADASIVALHTNRWWSQTKTAAAVLYANRHYLRLYRSSDSPRLCRNRAQIIGDVFIDSSAEVDQTAKIGPNVSIGAKARIGAGVRIRESIVLGEAIINEHACILHSVIGWRSVVGAWARVEGTPISPNPNIPFAKLDNKPLFNVDGRLNPSLTILGSDVHVPAETVLLNSIVLPYKELSSSYKNQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMB0</accession>
    <name>A0A0N4UMB0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DC_STAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10526</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001222">
        <property type="protein sequence ID" value="VDN60553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMB0"/>
    <dbReference type="STRING" id="318479.A0A0N4UMB0"/>
    <dbReference type="WBParaSite" id="DME_0000897501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000897501-mRNA-1"/>
        <property type="gene ID" value="DME_0000897501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF17">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DCST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000897501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="34961" checksum="B01A58187224FE96" modified="2015-12-09" version="1">MIYTLFRDSVNTIQKYLNDINFKNIFLTNYFWHIDEKRRAKNEIFLNPLSKAEKQTNGLLKPFSPPTRDEIHECWLPLARFAIILVTSIAAIVVEYTLYHLIKNVTLFDVGDIKDDLQQEFNFKVNGTGFIAELIQDLLNFEYKKKINISISTEKCIQLPLEPDWQHSLHYISLPLVMMFLLQVRYICIYLTIFLRIIQRFYILILREFSFKVIFGFIIRRATLFYIIGNVFRKRSKARTIDLYNRLLLVRINGRRIARARIRFQVHRHHLLQNSFKQRRHNCFDFSFNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMI0</accession>
    <name>A0A0N4UMI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10578</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001226">
        <property type="protein sequence ID" value="VDN60605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMI0"/>
    <dbReference type="STRING" id="318479.A0A0N4UMI0"/>
    <dbReference type="WBParaSite" id="DME_0000905701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000905701-mRNA-1"/>
        <property type="gene ID" value="DME_0000905701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826661at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="63"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000905701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21065" checksum="3F6E030625F1E04A" modified="2015-12-09" version="1">MPMTTYVIHFMDCPGGYCLSHHVCVERKCELDPLAPLDIFLNRYIPSTSSPITCSAEWTKNDKLNACYIVRYGSYDYQRGNEHCISLGGHLASVHSSEEMYFINSIAGGTTYWIGFHNDGSQRWDDSTVVNYTNYRRTQPDQCCPRAAAFCTLVNFIGHNGQWDDAGCDRLWVHQINIVCKKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMX4</accession>
    <name>A0A0N4UMX4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2965</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000093">
        <property type="protein sequence ID" value="VDN52992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMX4"/>
    <dbReference type="WBParaSite" id="DME_0000922801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000922801-mRNA-1"/>
        <property type="gene ID" value="DME_0000922801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079484" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000922801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19353" checksum="B53CF530716EAB50" modified="2015-12-09" version="1">MVILTIALALLYSVGNSCTRIYDEFCTQTNSECGHNMVYKTVERLIYTDEILNLETCIQECKCISDEYVQTDGQCIKQNNIPVRNETERISEILPKHCAGRLCALDEEISDTLCSLTGQKCGTNMVFKTVRQSLRMRLGMLSSTVCIQQCTCVNDYVKKDGQCIKQDRVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNC2</accession>
    <name>A0A0N4UNC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3110</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000105">
        <property type="protein sequence ID" value="VDN53137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNC2"/>
    <dbReference type="WBParaSite" id="DME_0000939901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000939901-mRNA-1"/>
        <property type="gene ID" value="DME_0000939901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030037at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000939901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16593" checksum="C8362F2F8ECD9C16" modified="2015-12-09" version="1">MNNGALEGSNEFSILSPNKQTEVLLTNQQSNGFSIPLLFNRMKPEADFQSLTMPKMTPNFSANRQISTSPVQLYNRRSESPLKNVTSRTSRFDNAGESFTNRLSKGLVDFTQGSSYRLQKWKNKLQNGRKQKDSSEPPPVFRFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNG7</accession>
    <name>A0A0N4UNG7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000108">
        <property type="protein sequence ID" value="VDN53172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNG7"/>
    <dbReference type="STRING" id="318479.A0A0N4UNG7"/>
    <dbReference type="WBParaSite" id="DME_0000944901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000944901-mRNA-1"/>
        <property type="gene ID" value="DME_0000944901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817707at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000944901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22244" checksum="0099E6AFEFE9E039" modified="2015-12-09" version="1">MKTCFKVHPKKIKKAKKILNCISDLGAMIPIMTKSFWENGMEYSCTDKNGSDIDNSQDFGSGEGLNDCYNNNEQVSNNFLISCSSKRIIACIDKNGDTLKEGFFLMGNNQLKFCRIYNNGKKARIESRGCFIGKENDDVMDESLHVKKYKIWRSGDYDMRCGENGVHVYRCHIGGNKSVYAGSAWIDSEQNFNVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNX2</accession>
    <name>A0A0N4UNX2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3284</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000119">
        <property type="protein sequence ID" value="VDN53311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNX2"/>
    <dbReference type="STRING" id="318479.A0A0N4UNX2"/>
    <dbReference type="WBParaSite" id="DME_0000963401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000963401-mRNA-1"/>
        <property type="gene ID" value="DME_0000963401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000029">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000963401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="45580" checksum="43673975D92486C0" modified="2016-06-08" version="2">MDAACRGHLLYKLADLIERDRILLASLETLDNGKPYTMAYTADLSLSIKCLRHYAGWADKIHGKTLPIAGDYFCYTRHEPFGVIGQIIPWNFPLLMLTWKLGPALSVGNTVVLKPAEQTPLTALHVASLIVEAGFPEGVVNIVPGLGPSAGHAIAAHPDIDKIAFTGSTDVGKLVMATAAGSNIKGVTLELGGKSPIIIFADADLDEAVKVAHSALFFNQGQCCCAGSRTFVEAKIYDEFVEKSKKFAEKSVLGNPFDPKTQQGPQIDETHVEKVLSYVDLGIKEGAQLVTGGKRFGDKGFFVHPTVFANVKEGMQIAQEEIFGPVMSIIRFNDMENLVEKANNTIYGLAAGVVTNDIDKAFHVANNIRAGTVWVNCYNVFDAAAPFGGYKSSGIGRELGEYGLEVYTEVKTVVIKIPQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNZ8</accession>
    <name>A0A0N4UNZ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10716</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001239">
        <property type="protein sequence ID" value="VDN60743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNZ8"/>
    <dbReference type="WBParaSite" id="DME_0000966401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000966401-mRNA-1"/>
        <property type="gene ID" value="DME_0000966401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000966401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19658" checksum="E29595A3733E6704" modified="2015-12-09" version="1">MLILCLRDHGCYMFSKAIVIDSISKYRIECTVDDIRHEMGNFASSKNVPKLMSRMGQHWRLEDDIIGGAPHPDICEYAIFSDGAGQISEKFASLVAERFELKTTPSCFQVRFKGFKGVLCVNPLLDLKGRENIVFRKSQKKFEEDEEEIAELEVVKYSLPTSACLSRPLIMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP66</accession>
    <name>A0A0N4UP66_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase-coupling factor 6, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3352</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000125">
        <property type="protein sequence ID" value="VDN53379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP66"/>
    <dbReference type="WBParaSite" id="DME_0000973601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000973601-mRNA-1"/>
        <property type="gene ID" value="DME_0000973601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000973601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12916" checksum="C1020E3F8718E04A" modified="2015-12-09" version="1">MLLMSNWRPFYNRPFPFNYLACNFRYFSSDHSSVSSTVPEDSPKFQDRIQKASAKACEQSKKGEIDAVRKKVAELNEYFSQYIDEYYEEDLPLEQPRVAKVKGYIYVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPR3</accession>
    <name>A0A0N4UPR3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10813</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001251">
        <property type="protein sequence ID" value="VDN60840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPR3"/>
    <dbReference type="WBParaSite" id="DME_0000996301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000996301-mRNA-1"/>
        <property type="gene ID" value="DME_0000996301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000996301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19646" checksum="DCD02916CC264A29" modified="2015-12-09" version="1">MTVAITECHNGGVTNDQPAQGETPRRPVPSASACHDNDQNGLCNALFPNDNIANNLNPGLPYKVHQNCFAVTHSSIATKFCASTCALCCKTPQFSSCPDTASNCTIFAQNLALCTSQQLSAFALERCAKTCGLCDKPGTTTMAASNCRDERVDCARHRQFCHVHPFSSYYSIFCRKTCEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQV7</accession>
    <name>A0A0N4UQV7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10899</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001268">
        <property type="protein sequence ID" value="VDN60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQV7"/>
    <dbReference type="STRING" id="318479.A0A0N4UQV7"/>
    <dbReference type="WBParaSite" id="DME_0001041401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001041401-mRNA-1"/>
        <property type="gene ID" value="DME_0001041401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001041401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11742" checksum="3ABC62F9DD855FBC" modified="2015-12-09" version="1">IGFSQTNRINNLRKNDDSSVYSEDEYVVEKILDKRYNSKTKKTEYLIKWKGYNNPSDNTWEPEENCVCQFLISSSNIACHYLRRFPSNNVGFFSKKTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URA0</accession>
    <name>A0A0N4URA0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4002</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000243">
        <property type="protein sequence ID" value="VDN54029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URA0"/>
    <dbReference type="WBParaSite" id="DME_0001057401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001057401-mRNA-1"/>
        <property type="gene ID" value="DME_0001057401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001057401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8430" checksum="23A1B69F4B6C132D" modified="2015-12-09" version="1">MLVSVNMSEKSTEVAADRPLAEEIASAHMKYVWLDDSIDNREPNFDGFEVAHKERIVDSLNARGGRFITFFQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URF4</accession>
    <name>A0A0N4URF4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4055</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000263">
        <property type="protein sequence ID" value="VDN54082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URF4"/>
    <dbReference type="STRING" id="318479.A0A0N4URF4"/>
    <dbReference type="WBParaSite" id="DME_0001063401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001063401-mRNA-1"/>
        <property type="gene ID" value="DME_0001063401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="613"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="782"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001063401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="912" mass="103893" checksum="1BAA7E1C782D44CB" modified="2015-12-09" version="1">MGVTKDYLRYNLSGTCNIIASTNGVLVAITDSICAVAACENVYFYNLRTCEKKIYFQFGLKTWMISKCDLNMIHLFYSFFYFIHYILIGFSDKCEFITFSGHKTGVNCLAFSPDELVLASGGKDSRIVLWDIVNECGLCRLNGHKGCITNLQFTQNGHFLISSSKDTFIKFWNLHTENCFYTLTDSRSEVYTFALLKNDTLLLVGTAELEIRIFQLRWFAECETYDEDLNSIDRNTEESWSDVDGQANVIFYIVCHTLRYVRCKKLGHLFRQAKGRAVQIAFSADERIFTCLGASNVVDIYRIYSDDERRKRISKKLRRAKKRACERGETDTLAENDVAKDITTIISRIGDYRSNSKFFALQANNALNFVVATANFKSNKIEHSILSNLDKLGHRYDIRCLAMAENDFGFASGSSECAIVWNRYSLKIINMLEDDAMKEVTAILFVTGDKHLITGTAVSSGSLFLFDLATNEALDFRKKAHSGVIWQLSPTPDKKGFISCSADKKLIYWSYELVKDMFKNVLSFQSRRILELPDEALCLAASTDSRLISVGLLDNTARIYFVDTFKFFISLYGHSLPVTTIHISSDCKLVITGGADKTVKIWGLDFGDCHKSLFAHNDIVTCVQFVPNEHLFWSAGKDGLLKQWDADKFEQIQVLSLHSAEIRAITQTNSGRYLISASHDKSVRMWELSEEILNLQEEQEIEREKEYEKRLIEVEDIVPGEERIVEADLAAQKSIHSIASAEKIINAVEIVRKEMAAKGDNPYEQHNSLVQYMNSSSFDFFILDIIQKIPSSHLEKSLLMVPYKFVPDILHALGTCISKYYRVELASRVLMFLIKIHHNFIINSSELLPTIDVLRKSVPLALEHLKDVCGYNFAALRLFKKQIEARTETNFFADVSEISTKENRKIKKKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3D7</accession>
    <name>A0A158Q3D7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6572</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3D7"/>
    <dbReference type="STRING" id="318479.A0A158Q3D7"/>
    <dbReference type="WBParaSite" id="DME_0000221201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000221201-mRNA-1"/>
        <property type="gene ID" value="DME_0000221201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000221201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16914" checksum="3219B71C12A9D167" modified="2016-06-08" version="1">MVAGSIRVAFTETEWARVTTLFRSDDLEDLKQAVAIFCCWRARSGLALHIAAEISDLILRSIIADKETDENDWFAIGNLLLVYNSAIIRLFFETIVSQCNTASTGYEDVSKLRDLMLSSTVLETNPFFHRQSPYIASPHIRLKSFPTVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3I7</accession>
    <name>A0A158Q3I7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UAP56-interacting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6858</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3I7"/>
    <dbReference type="WBParaSite" id="DME_0000249801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249801-mRNA-1"/>
        <property type="gene ID" value="DME_0000249801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5833948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="49449" checksum="F7ED884600570118" modified="2016-06-08" version="1">MTRLDGPTTKILINIWRFIDSHLLFRLWRREAGGRFSGGGVEWLSFTDLRFSFFLHLSCKNCLKTCVMFRYLCILCFLFQRFRGMDEKINMSLDEIIKKEKKFVGKKFLGKRRSLKRPRVTNNFGLKRRARKSSLANISNQNADKTGSATLRLVNRLVKNAIRSQANQTLISRAAQLQRRRIAVRRMAKRPAGGRRRFMARSSLPADRLRGVSQRSRIIFGRNVKGSGAASVRRLSGFRSDSVLRGRGTRLGHLVSDVSPVLNKIKYVPVDTVVKNQLPIQQRFTQRSVWNRIPQQQRVVIVDEVVLILFFVIFPFSNCICLFWFTWVQMTIWAERLIRPHGSIRTPPVRRQKFRSRKPVFERLQRDNRFRGSNPDAERMRNAFGIGNSRKFGIDESANSFLDRLHEDKQRAPNRRFNQIYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3K7</accession>
    <name>A0A158Q3K7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6960</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3K7"/>
    <dbReference type="STRING" id="318479.A0A158Q3K7"/>
    <dbReference type="WBParaSite" id="DME_0000260001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000260001-mRNA-1"/>
        <property type="gene ID" value="DME_0000260001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039052at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041046044" evidence="5">
        <location>
            <begin position="26"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="976"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000260001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137983" checksum="CF44C68EA669322B" modified="2016-06-08" version="1">MNGRRGTSVLLFSFRMVVEVPLCFCLQMTQLPTERAKPKMMNEICINGSKRAESIAPKIKELFDAVRKGETDKVNQWLANKRNKRPRTPLKFVRPFFLKSFLRPLTPQISSSLRSIVDPSNGYTTLHLAALQGHSDIIKILLDADSQMISVRDRRGCLPIHLAAWNGHHQVVKILVELEAESVNSVNNAKESPLHLSAQHGHTKVVAILLAKHADARFRNARSETALDIAAKLGKADVCRLIICNCPELALQSAADCSLTDPSKVKQNFHVVYPLHAAARHGHIDCLQILCQSGFDINYVTDEGSALHVAALFGKVQAVKLLLEKGINTDLRDCQGRTVLETLYEHENQKASDLTQVIQSREGWLECRKIIQAYINEKTNINEGSHTMENNSMVQINSNVYQNITKNGPESNDVIWRSIPEGSSARSRNLTSHFDLIRNAAAINDSFYYPSSIQADLVSCDFDEDYNSVTENSSSTLLEISDYNSSGQLSPSCDSTSCSSIKHLPVFPVTSPRNKTRHTASSRSGNLLPKMGIARQSASCSYQAPQAYDSWTSRHLPYDNIFLPSYPVMAYDNVPRNLLFYDNAPPPGHRRWDHTCHSSGKSMGSVGHKFITTPSNMHNDGRKTMPTARSYRPRTALQDVQFKLQQPELQSNPFGELNESLKNINGSNTNHDRRSDSKISVVTFACSSLEGSSASPDDIASKASSATNVLSSGRAPLAIPEEVSVSTSTSIISISTNSDQNMHENEFCEKQKKSTRTLSDETSVSASSSTVRPEDASCSCKCDSRKSCELTSDSGSSSLNGYNLDDLPSPETAESRIRDFLCNQLNIENEFNSLSLISAPNKSQITEDIILSPSATDYSDYTLASSCSLPLISKSLSSNPSSVASPNKDNDNFSKPPSTDESISSVRNRSMLDSKKFMGLGTSDNGCQLFYFIHASKNVAHWLNLVVGIPNPKAIEIATILENNGFDNVDFMFIYVSDWLHSLGLEDYLGIFMRGGLTTMLIVSAVDPTQKHLKNLGISLLGHQKRILNSLRQVHYDNDAGKTLSVVCDDNHGEINGGQENRNSVQLNVQKPCSIFVGGRQTEWRHSSSKLISDCVAYSAHYLGSVEISNVESTEDSRRAMVKLKKDIREITKVPQVLLEISVYGIRVLDTNTKKLIAEHEITRIQIVCQDERDLNCFAYISQDNDGHFCHKEIMKDPYCILLFQDVATEIIITLGQAFEVCYRIANGTFEENQPVAIHANDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3L2</accession>
    <name>A0A158Q3L2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6999</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3L2"/>
    <dbReference type="STRING" id="318479.A0A158Q3L2"/>
    <dbReference type="WBParaSite" id="DME_0000263901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000263901-mRNA-1"/>
        <property type="gene ID" value="DME_0000263901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76898at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000003">
        <property type="entry name" value="Protein CBR-ITR-1, isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF102">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2156"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2195"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2218"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2259"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2307"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2396"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="14">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="14">
        <location>
            <begin position="271"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000263901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2564" mass="295685" checksum="D0F4DF1B43BB4D7B" modified="2016-06-08" version="1">MNLGSNKTRQKLFYDKSNLSSEVFHNSTLHIGDVISLYTEDRSRQSDDRNDDRTFIKTGLVDDRCIVEIGDGNPEAPPKKFRDCLFRICPINRYAAQKQFWTEQKRFREGESVFEEDMLAKLKNAADKEKEQNEMEYQKMLGSIVQYGGTIQLLHVKSDKYLTVMKNTPAKLERNAMKVCLDKTGNEGSWFYVETVYKHSFLGDNVNSGDRISLVPYSYGSLSGNTGIIKPQIHLSHMRLPDHPQGYEVNCVNEHTEWQVFVFLQFDENRGDIIKSGDVIRLFHADQQTFLTLDTIPKKGKDVVFLRLTNRPSAADATSSRALWEVQVVQNEACRGAAAAWHERFRFKHLASDMFLTVKSARDMRDVLDMPPASSIPENIFDYSKNEKGWVKVIGEDQRVDKETFALLSVHPNEVRDLDFANDACKALTNFIDLIKSGKIIAKESLNIIVQLLTECIYFVTNQANHLVDPLKIVDFIPSRDRQKLLREQGVLKQTFELLRVPFEPRRGIMGPLLLSPQELNEQRNDVFKRMFQLCYSLLRYSQVRYRKNQEHLAEQFGLIQQQIGFDLLAEDTMTAVLHNNPKLLEKYVKDPHVQRFVELVRNNKTGKFLDYLADLCVCRGEANKKVQELICNCVLSEANRDIFMLQIKWGDRYMKSLIAMAKGVSIGDQEDSEMLDYYKHQLDLFAQMCQEQQYLAIDPPPERHLLNLSAELPPDLVLKCMSDSRLPDNLRASFARLMLHLHVVRGSPLNAIRYARLWKEIPERVSILNCSSRPVEGYATSGRARSGYANLLKAVSDYLLSLKNITKSGENVLNDHSSRLEQNRLTFEMVTLARALAQFGFYSFAQLLQLAESLLAITDNNSSTTPASHFFHQVTYSVMGVGMLEKSGTLNSTLANDAVDVEENVRSKASKDIIMEIKLIVVEILQFIMDVRRDYRITVALSWFKQKNPCDEYGELTEPQALTTKHAMEIYKEIFERTEEQLECGGQHGRQLLKTLLQLATSECAKLASSALKVLFRQFTQYHEFVDDLKQVQLLVSNEDVENYCQIDRDLFILKILTEKSELWVNAGKASESPIIDDTLRIEDISADGLNAPRAFCNDESFHLLVDKLDEYYSPTRDDCIKLLNKLLLSDDRENAASALFELSDKAPLIGYPLIKQILFRLKQLCYKNGSNDIMNQQLLKNMRVHEYVLGFLSIPYDKRVDQEMPKLFTLCHEFLQSFCRNNKLNQYCLQRYISVDSDHKEGCLRIDTVEDVATLVAIYKNNRKLSENISGDIIARVIDLIEQKARNAVFIEFLQCVVCTDEGEIESSQEKVVQEICSASDEVRVFYSDSASFEQLIQMMKNTPVEELTADNPLRYHIELVRLLAMCTRGKNGTMELKCASQLPIDHIMRVLSSPHCLVQVKDVYMQFMLHCYIDTGAEMKDVYNADYFELILQNILSDVEEVPLERYICLTVIEILSSLFQKPLSYQTTMDVVSHITIYFLYKSSVKTLRSASKNWHRFAESLKRLNKCGSYFSILQNYNHEFEESSRFLEDAETSVLVDLLYSPERLFPKGSEMRERCEKGETIAKLIEHCKQLLEEKQENLCVRVLHTLCHMATNTKFICRDQVNCLFHIFTRTNCKIGICLRQHLLQRYFGDESERRRSKFGSIIEKQERKPSSSNLCRNYFPTILFTDLFSDLVIDLIIEEPSYDVFYMTMELAKSLLQEGNEQVQKSFYKRLTQQRDVSETFVQAIKTKLQVAQNRVKNDMMACNDSRQPSCLQTPLANDLTLQNEHRGSLDTSINLMSLQAENIDAIYFYRSKKSLPPEVLIIEPILRFLQLLCENHNLSLQNFLRCQGSRKNYNLVDETLTFLDVICGSTKGSLGVFGDIGEHNFSLIIQTLTTLTEFCQGPCHENQNAIVYHETGLNMIISLVLNEIKPLCISHMDLALEIKSVASKLLLATMESRHDASNAEAVLLNMSHMNSGPTQLIHALTVAYQMANSDTYVLSRMRRQLLENNISGQVLPEISVHGPVKNIFDQKFSYSNLVDPQEVGHNIFILATQLSRHDKSLRDLLTADYFDCEMTRVAITYYKQHTAQIEIVREDRRMERVIFPIHTICKYLTPETKQNLLVETERDAQGSKVSQFFDQWPKLFQEMKWQRKLQDRKYLSSCTKHLILWARLSFLFAIFTNIITAIYYPFNEDTRHASFGREPEAYIGIAVVMFISTLLAIRSLDVLLTLQLIGILQLVNKFVHILSYIGNRGLIDRTWSDRINDRDIWYHLLYVVICLFGLSIHPLFYALLLFDIVSSDETLRNVISSVTRNWQSIIMTGLLALILVYLFSIIGYLFFQKDFRLEVDPMNSYAGESKANDGKIWSCQTLRMCIITTLNWGLRNGGGIGDILRNVPPDEESFFPRILYDMSFFIVLIIIVLNLVFGVIIDTFGDLRAERNEKDDILRNTCFICGLERGRFDNKKVTFEEHRKNEHNLYHYLYFIVWLQIKDETEFTGPESYVAQCIKDRNNDWFPHMQAMSLIDGEGQELEQPEEFNNLKEMLNTLLAVSKNHDRQLEELRQQFVAFSKFSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Q6</accession>
    <name>A0A158Q3Q6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS163</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Q6"/>
    <dbReference type="STRING" id="318479.A0A158Q3Q6"/>
    <dbReference type="WBParaSite" id="DME_0000293401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000293401-mRNA-1"/>
        <property type="gene ID" value="DME_0000293401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF19">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000293401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="882" mass="100105" checksum="4C27C418FD9C068C" modified="2016-06-08" version="1">MSTKTKSFDDDNKEICVASPSSSSSSSSPLSPSSSSSPSSSSSSTPNNSNNNHNLPSQIITINDYFHGFISKKEAEKRLKKCGIEGSLLLRADQLKYTTTFSNKQQQRYYLSWLSPINHNIMHYPITLVCGAYFIFGRSFLSLSDLINYFIHRSKNNVFPLRPPSAVEITERQRIAILPFQALSDSDEISFYEGDLLMEIQQVDDQWIWAKLDRTGQSGLVAVNLTLPLNDKRIRPEELPFFHEDTVDSLNRLLIESGAGSYLLRRSSFKQNSFALMLNSGRRIEKFLIRRTEMDTYELGGRFFQTIPDIIDRLMPLIVNIFRYSHREICDGSKLVKAVVKDIVANARKPLNLAPSDLRHLLSYNSCPHSVAYSPACRKLKDNKWKSCFVMLNDANGSQLYIFENEKRAKPKIVLDLCFCFVYKIDESIIDRSNTLCLVLNGLNEYSSVYLSFRTVNVFLQWLCNLRNRCLGCRHTASPFTVLQSTCTTFLRSTSVIYLTLSSYRGAILKPDYAYSVNVFVNAVPVTRTRSFIPSAKNYITFDARFFLEHDSETSALYMLPDDGSELCVSSEESTEGFVFRVTRHRVALLPEDQYSSFFVLLSSHSFKLCLWIGSILNNFKRNHFSRLLLTVFIPNYSLLFAFLKVLVEDQLCSESESTLFRGDSFCVCCVSNVLKMLGRDIALDQLSPSLDQLQSEKTTAIDSEKYIMQLNDLIFRLPPAFGATLSLVSNSSSIHFKSSSVARRAVSTFFILRFINPILTFWNVNGGPTRQLAKTLQITANQACSTDVDLVFFPIGILRNISNNQAVRSMANLLDAFVNSPRVDETTPNPFMGYSRIDHLATLAFQVERILDQRPEECPLPEALVVIRLLKAHAERYLMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3R9</accession>
    <name>A0A158Q3R9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G protein gamma domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7198</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3R9"/>
    <dbReference type="STRING" id="318479.A0A158Q3R9"/>
    <dbReference type="WBParaSite" id="DME_0000303901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303901-mRNA-1"/>
        <property type="gene ID" value="DME_0000303901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="6">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8632" checksum="1EF05B05AE1C0C64" modified="2016-06-08" version="1">MSTRDMHSVQQALKVVEQLRRERNIRRGAVSASIKDLIRFTQDYQRDDVLLTGFQNDKMNPYRPKSSFQCMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q402</accession>
    <name>A0A158Q402_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rif1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7712</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q402"/>
    <dbReference type="WBParaSite" id="DME_0000370701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000370701-mRNA-1"/>
        <property type="gene ID" value="DME_0000370701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8193282at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000370701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36784" checksum="D87472D5460AB0C6" modified="2016-06-08" version="1">MVLSFVQGVKKIIFTKLSKKKPEIAKHDMRFLSMRFLSERNLLFSASCFVKIFAEYFQESSMIEEFVPVWLVVNMINTEDEDMVQSSNFVYNGLSAFFAQRGFNIIDKKLNYVSAIEVSQWIFKVIGEDCKNRICISQWINLWIDKIVSVLTHVLPDAQQAAIQHSCRICSFIFLYCAPLIFKTPSECIFNRSPFVCLCKLYLQNLVKSLVFYHFFRFFLSSKLMYISEIYQNLPVDLIEDIIPNFIIGLVKLPISTTPYLFRLLIDAIERFSSNFFINEKLCEILQPHSDLIQKLRCTSSRDSNVHKFISSFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q444</accession>
    <name>A0A158Q444_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7988</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN58015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q444"/>
    <dbReference type="WBParaSite" id="DME_0000398301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000398301-mRNA-1"/>
        <property type="gene ID" value="DME_0000398301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056075">
        <property type="entry name" value="DUF7658"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057017">
        <property type="entry name" value="F54D1_6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057018">
        <property type="entry name" value="F54D1_6-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057019">
        <property type="entry name" value="F54D1_6-like_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF60">
        <property type="entry name" value="PROTEIN CBG06057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24678">
        <property type="entry name" value="DUF7658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24469">
        <property type="entry name" value="F54D1_6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24462">
        <property type="entry name" value="Ig_F54D1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24464">
        <property type="entry name" value="Ig_F54D1_6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044449" evidence="6">
        <location>
            <begin position="18"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="8">
        <location>
            <begin position="144"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="7">
        <location>
            <begin position="500"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000398301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1266" mass="146834" checksum="A73D237A7E566D53" modified="2016-06-08" version="1">MLSLSLLSLLILKLSIAYDGNTEYFSFSYDEANLVEYGPQAGDADISTNQQANGMTIRLYQFFPFYGAKYNYTMISTNGYIGFGHFSDNDHDFRVGSETNWPRESDPALIAPYLCKQRIDISTNSRIYYRMEMRSHIALSSETTYLTRSKCRGKLPYVYCNQQSNEFLDKMQNILQEGAAGGNTFRAEAALIVTWHNLRPNIGKERSFSTYQLIWMTDALGTLAYTIINYDKLAYDAADLNGNTVTGRCQAIFNGGNHTGFVLVDASLVTKERPSSLMERSAVPHVVRGRYLHRVDDIVRPVGCSNKTGGTCEELIICFLLNIYPNIVNMLGEKTVEIAPCHVLNPSIARCYLPKILDWGTKNVYFQPQSGLANDEKAYIGHIYFVPPTIDPLRLDIGNIYDWFRIIVNNNKHVVWYPRNFTNPRLHDRMFDKNDRSLYETQLGLYVIGYKESRDDLAKKFKPMHRVLARIISAPISIHWLWPLRFDENKDDLEERKKFIKEKATDICEYWFDEDGILPNFIRQTETNASCPCKENQASLDIGRFMPHPRCSQEHEGRSRKFFLYFDEFTPYNPGFPMRAYEFGTPPFQGMFETFRDIVCTEIIGSKNCYITAQNIRGSHYDKNENNKIGFQTNLYSTHYGQVCCYDDQGFLMQTSYQPVIKIDEFTPYNPGFPMRAYEFGTPPFQGMFEIPDLSTFYHDLMPYYFCCKFADFRCQLFYWRRPSSACQHYIPPLIGTLMGSGIITTLQNEKFVFNDAGIYKFLYVERTTLMPEVNIQIRMERFPYRNVDFSGYNQEQFKLVQPSNATVVTGVALESGDSDRVHVILRKDTRRMRYRTTILVNDIVRYFDNMQLQRYKGVSIYINNVQQGQAEVYVVLHEAQIGVRIRESYALDMDRFPTYMESFGFLDLLISVPSQYISGSNELNGVRMYGLIHPIDHGSFSNRDSGLTWNDINNPSLRDNLIEKYRIKGETYMEISRKLSSSIDMFEVPSDFVFSALPDINLKKPVYVSDIRYYSGQYLFVPQTLESINRFKEICTNYFVDEDLMDPNTNLELRRCPSFMELIQSDCNKDIVCELDSILLQAKIIGEKTRDEYYSYLEHQQLASIRYNSCGAITLEYPDYMMKGPSSSMPGYLEGDTVIFSCFQDHITKGDTDYQCTRRYDKDNVNNYEMRWNEGSQPWCRSRQAEDIIVWTIWSLILIGKLALIILIFLFCWIIKQNHLSLERNAIRDNTKTIKASNQIPLDNDFSLRIMEKPPVNHASVISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Z9</accession>
    <name>A0A158Q4Z9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rod_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9437</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Z9"/>
    <dbReference type="STRING" id="318479.A0A158Q4Z9"/>
    <dbReference type="WBParaSite" id="DME_0000614101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000614101-mRNA-1"/>
        <property type="gene ID" value="DME_0000614101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868545at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055405">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24515">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="2">
        <location>
            <begin position="401"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 third ARM-repeats" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000614101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2117" mass="243173" checksum="A4BE03DDB4CD86D6" modified="2016-06-08" version="1">MGRFTNVNLNFSSDEESVFDMRDEFSSPDYLYETNTIAIIKEENEEDDREDDETMHFDALIDPAKCASDMPYIIAASNNDFLAIAVGEDLSFFSFRFGISYLVTIHLGDGIEINALCFLPSSDLMAAVTSEGILLIFNAFWQKLIFKTKIVQENKVIFICGSKNQDKCYISILSERGGLLTVILEEYTKWIGACDKNSLNSAIQKTFDDFPVFRLQCEHPCRNLVILSDQQLLLLVTTKPGSPLISPIIDYMAESSHKNGLFAPIDLSDGRLFVRIQLCDDGHSAIAITQDGWLVLYDLWTMMKYAERKMISEKEFVKDFILLGQSKSSLANCKIAILVEDSENTKLQVHRIDTTEMIYATSISTNSQLLSIATEDGDIIVTGLVFLRSVAECQPQIRLNRLLNRSQFDEAELFAKKFKLDLQEIHKSRVTRLLSKLVSTNVDLLMVYMDEISDHNWIGETCISGATIGRDFNAVLKLLTYAENREISDEETLRKLIRLRYNLATYRMIYGPEKAFFNYWLEFVGDLSWVEIFLHFCSQGNFAEARLIWSRYRNVLEVWIVTEHDSDDAFRKILEACNDPLAVKITIIWDVLCLLENEVIPIALLMNTAQRLKRCIHWLRTICNKLEMDQPTEFPNNVLKVASTIIRVSEYMIKYSVTPGQKATTAHIFSLMKIDSMDPNDDLGALNIMINNLREMEKLKRIYLCSMSYDQYLEQNSQSICYMILDRARSVELIKKEIEQYAKPFMNEYKLHADKTLYSYILAIADRYTGVVANTNPWDEQCLAVAETINCRALRCEAVIGICKRAYPPWTRHLSNAVEILLNESNIDSKLIKKLQYQCHFAHLAEMMMKYMVPMAAIDKYLTSPRFFLSGVQYILKQTTIEPDPQKRLNDVLKMVDMATKIKNNLMDRKHCIVYFCVYLIKDVKEDEMLNEIIRCLGNINESERNTIIDDFLLYVHEATNTKNLFIYDIQKEIRLKYISAALCILEKFVENGDQMKRNLRAMRNMQEKFSVFIDCHLLENEEQKLEMLKQFIDSKLNSESMLKWTEILDYSRALAVDDKKMTKLLVERSVELENPTVAIHAAQSLLIFDPQPCEKFIKIALKSCEYALWIMPSVNTESNLDTIIVLLEMLSNLLPIIVDKSSLSFQHYERANMDNIQYLPNEKDPNASDKTVNFWNSEIYGIHKRIGTYTSKSDGTIFDKVAAIRAIVAVSRSTVVNPPILIEEMDEFNNLLRQNWQSLFGFLNLNNQFLLEFSARSCAARMPCFINHRDMLVDNLKNTVVCFIERLLSQNPADLWLCTAALFTLPEEQIKWALEKIKRWVAFRKVPNISVYFLQLYQFSNIVLSNHSNQNWSRSEEINVINRHYALNIWAKRLNKMGLSLLPNEPLSSIIHEFVKARITVEILIEYCTTFELDCSEATIQYAMQMLTQSCLERERRIANEMLRMASHAFLQLGHVEDIFYRLCKCVTSLCPYDYEALEVLIIELKKFTHHNEEVYLKLAEKFSTILIFLSTFVRSNAPSDAEIIWYQERQKYLSKGEDGTDILNKLRKNLIETSSIEALTSIQDIDDSIYEKPQLIALQLPLNANIRLPFHIFLFDDEKDIKSVLLPIINCELTLYNVKLWQYFARTMPELKLSKSCLLSNAIMLAMLAHINNGTDIGTDELNTIADLIFSTGNRIGTIKAIMLGFKSLPLCETKIRFLLVAINVAEKWLSATSTDLSKPVTNDEIAYIERYLTAMKPASQKYRAELLLQKFNFLDQDTANLLSNPEELIRYIYCNRINWNDVNDRGSKVSLIENLAAIYGFNLPMLQNKLINEWLSGECVKNIFDPNDTIGDVVPISGKTTLENNYALCSLPFLDEFTSRIVELSRMRETKQSIYTLAYLLKQNSPNVSYSTKVRCLCCLLRLLSAQELEDIVGGNLQTVCSNLELLLYADLIEASKVDLSLETFKAMDKGILLKSLLPNSPPSKLINFASSLVIDYQIADTTVVVALLYKLLQERRYEMLQQLLLFCSLNSGLNNIKAIPLAWARLADWLHSQIAQKIFGSINKHSAFSSPVELRRAVDSMKNSAIMVSCPVASQLLQIASYATTRTSNDFQVEVPDYDVKMEWAISTRDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q572</accession>
    <name>A0A158Q572_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycerate kinase</fullName>
            <ecNumber evidence="3">2.7.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9691</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerate kinase type-2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q572"/>
    <dbReference type="STRING" id="318479.A0A158Q572"/>
    <dbReference type="WBParaSite" id="DME_0000666501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000666501-mRNA-1"/>
        <property type="gene ID" value="DME_0000666501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44918at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10180:FF:000001">
        <property type="entry name" value="Glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="entry name" value="Glycerate kinase, MOFRL-like N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="entry name" value="MOFRL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82544">
        <property type="entry name" value="GckA/TtuD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL-associated" evidence="11">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="10">
        <location>
            <begin position="359"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000666501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="53122" checksum="DB631DCDCD36A0D7" modified="2016-06-08" version="1">MTFMASSTDFPSNQLLGNAALHAFLAAVAAVQPYERVRNILQLKDGKLVFGRRILNVNKNIYLAAFGKAGLGMVQGAEDALGDNIIEGIASVPRGTMKTISKSYHPKTQFFEGATNNLPDNDACLNAAKIELMARKLRSADDIFLVLISGGGSALLPAPVFPITLEEKLQITKLMANHGADIKQLNIVRRALSRLKGGKLAQIANPAKVLSIIISDVIDDRLELIASGPTVLREFSGNDHEPIEILQKLNVLNEIPTNVRNFLSSLDFEPSEKYQGINVLNIIVANNKTAINKIKEILEMNGFVCHIVSTMIDENASNFGYQLAILIETILMDKSGKRRFAAFDIANADLNYPEADQLALIFGGECKVEIIGNGKGGRNQEIVLAAFCKLLELNYVTLLGDFALLSAGTDGQDGPTDAAGAILTKEDLAFVQNDKRWKKNYIDSFLSRNDSYNFWQIFRNGSCHLKTGPTGTNVMDLQILLFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5K3</accession>
    <name>A0A158Q5K3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5K3"/>
    <dbReference type="STRING" id="318479.A0A158Q5K3"/>
    <dbReference type="WBParaSite" id="DME_0000761801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000761801-mRNA-1"/>
        <property type="gene ID" value="DME_0000761801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000761801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29254" checksum="00D415367792A6FE" modified="2016-06-08" version="1">MVNPEINNSGDSAFQKHANIGTACDSPVCSQKLATIDDEIIESTMMIDDQLIGYCSYGHGETKLLFICGGVGCYKKDYPEHVLRAFDSLVYTIVCIDPPGYGKSRPPDRKQEVNRCMKDAGFCIKLMEQLNFTPFSVLGWSEGARTAVHVAGQGKHLVKAMILLAPATRIDQRGAGIFKGMRNLDDWLPGALEIYLQYYSKEFVAKQWADLCDVAIQVYELLGGRFPSDYILPTLKIPALVITGGMDRFCGDPKYFPTVLSNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5S9</accession>
    <name>A0A158Q5S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10270</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5S9"/>
    <dbReference type="WBParaSite" id="DME_0000813401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000813401-mRNA-1"/>
        <property type="gene ID" value="DME_0000813401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5597648at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000813401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56969" checksum="2E4118C85589FB2C" modified="2016-06-08" version="1">MSDSDTESFHSFDSGNDYVDNDIESVKEVVVWNGKIARRNDCSSDELVISHSSSPKFSCSFIASNRLTEQADQETGKLARAREIGDAKDSFDVGEEFHKDTEISESFPTDTQLFEGASSEANNKAMDVDGWEDWNIEMEKNENDTEKIADENSTSEDFTNLFQANKKTTITNDFSFWKWNNFSQVLNAVGGGISNVVESSLGLPKPEELAADEKKKEFVKDKEVMQDSDAMISSFGNLLSGFGSNMVSGSLDVLESLGKTAFEKLTVSQEEGKRRRFIFESHNDQNLSEILRELQEAQRIDEMHHFDNCFGKSKRKNLIDLFERSGGFVHLEGLEMLSGNYAMKFSSYEKVANGIMAKALSEELKDCCENEDFAGQLNRILSDINLPYDGSSLLLCESQCNDRCSNLSKDSLLAYNDCLDICSMTLPYLVMVVFLETIADLTADSVKMFHKLAQLMLITDEKPSPEPFVDFLFLIGRRISFYSNQYANKFNSTDELDERVSCCWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P589</accession>
    <name>A0A3P7P589_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P589"/>
    <dbReference type="STRING" id="318479.A0A3P7P589"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF76">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="153" mass="18489" checksum="1D44D1E8A61672BD" modified="2019-02-13" version="1">MRFIERPSITSTAFKSIEAEVMKELYEKFSAEEFTKRFALVDCRYPYEYNGGHLKYAINIHNRKDLIDYFYPSDQEKLNEMLRKILIFYCEYSTKRGPDMAFALRSEDRNRNIWKYPTVDYKEIYLIDRGYQNFYETFGSQVCFSLLIISYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PJ72</accession>
    <name>A0A3P7PJ72_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000371">
        <property type="protein sequence ID" value="VDN54210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PJ72"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6853" checksum="FC89B280B10B3EA4" modified="2019-02-13" version="1">MNFFIIKIKSVSCTDAHVDCPSYRQLCNFGDYGICRRTCVLSNDKRFSPELSICPSKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PLR1</accession>
    <name>A0A3P7PLR1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PLR1"/>
    <dbReference type="STRING" id="318479.A0A3P7PLR1"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="36010" checksum="4520174DCF29D580" modified="2019-02-13" version="1">MRRKRKQIEAKPTIERNSGSTRRASTAEENDKIDPNANHCLCNQPYDPKKFYIRCDICNRWFHGRCVKITEKQSKKMSDWSCNDCVNEQKSDQYLHVILSKFNESCIIISDIFLKEIYCVCKTPYDDKRFYVGCDGCQGWFHPECVGTTQMEVTKISEYLCPKCINNTHNSSESNFSVNSSIQLHRGDYKHLLRIYELLFKHRNSWPFREPVDQKKYPNYYQVIKKPMALSDVYNKMKELGYEYLSDFIADISQIFDNARMFNPKGSPIYNCAEILDKKFREEIIRMKGVYSETVHLGRLDSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPH3</accession>
    <name>A0A3P7PPH3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transcription factor Y subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CAAT box DNA-binding protein subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nuclear transcription factor Y subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPH3"/>
    <dbReference type="STRING" id="318479.A0A3P7PPH3"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000099">
        <property type="entry name" value="nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="141" mass="15779" checksum="0854FFA3F73C59D2" modified="2019-02-13" version="1">MPSTADIHQGKGHFEQNEAEDGAYDENSKGQVLLEQERFLPIANISRLIKNMIPSTGKVARDAKECIQECVSEFISFITSEASERCINERRKTITGEDLLAALSALGFDNYVGPLTVYMKKLILFNSAFFFKNQPSNVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PRX4</accession>
    <name>A0A3P7PRX4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PRX4"/>
    <dbReference type="STRING" id="318479.A0A3P7PRX4"/>
    <dbReference type="OrthoDB" id="5874683at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="498" mass="53416" checksum="9565773D9D666366" modified="2019-02-13" version="1">MAKQLVHLKGSPNFTNLRADYTPLMEASCGGHAEIVKFLLDQGADINAVSSTQNTALTYACGGGHLQCVSVLLAYNCDITMQNSNGHCALMVAASSGYADIVHLLVKAGASPTAKTLQCDFKVGVESPLTLASFKGHSDVVRYLLKNGANQRPEELHTALMEASMDGQLEVAKLLLDNGAPVSMVSESFESPLTLAASGGHPELINLLLDHGADIEEPNDEGYTPLMESCREGHLVGSLLKFLLTMIMRKSTTVDMRLWDCVEILLDKGAQINAQTEESGETALTLATCAGSKPVVELLLKRGADLNIGSNTPLMEACQEGHLEIAKYLIDEGIRRKGLPIDATTAANETALTYAAESGHLDICALLIELGAKVDHEASGGQTALMKAAKNGNYGVVQFLIMRGAQVNKISKNNEATALSLACAGGYWEIVRLLLDHGADPCLVLKDGTTCVIEASRNGHTRIVETLLNWHGNSQLRPYFKKASTIMHKKRSKKVIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PX79</accession>
    <name>A0A3P7PX79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PX79"/>
    <dbReference type="STRING" id="318479.A0A3P7PX79"/>
    <dbReference type="OrthoDB" id="5831138at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF8">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="repeat" description="CSPG" evidence="4">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="4">
        <location>
            <begin position="283"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="4">
        <location>
            <begin position="500"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="901" mass="102273" checksum="FB32025FE7E0CC1F" modified="2019-02-13" version="1">MFRLDKIIRSTSFNILFDNLISELLIGSGSDRDKLFICIENIKFGGDNLLNKWCSDGSSLEQSSNDDLPVTIEPLYVAEILQVDEGWLFPVTNTNLKINLTAFVFDKSHIRIVGIPQHGSVLVRGKPENDFTYQDLLLLHVNYSHDGSETSEDAIELQVNISGLMKSLIRINPINDAPELRKGSEGLRIKYRNCRLLLDTRFMNLWDSDTDSDIVRVDIVSANGVILQAAGHNITQFSQQDFINNKIHLVNTGEDRGEIHLIANDGEKQSSPLLISVITVPIEIHLKSNTGVKVMHQSSETILPANLSFTTNLPDLPLQYMIVDLPEYGLVECCDDVGQYQICSSFMQNDIEQSRIRYRHTSQLNPPVDSFSFQVRAGSSSSIVHFFKISFIPVHVKIFNRAPFLLNSTDQLTLRRLHLFAWTFPKSYSPQNLIFHVIEPPKFGLLSRRISETRNRRIGVSSNFTQQYSIVNDFFIFRVITPSVASEATRFEITFIPGSGAVQLINRTIVVDEGAMQKITNESLSLETPDDNNFMFTIGIPPLFGNIVLSHPLGAKFILSMGENFTTQDINKGRVWYEHLGVESRVDRVYLVAESVHRHTSRIPFWLTMRMILKNDNTPRLVGKNELQIIDRGDRILRESLLPWKDDDIDTQPLRFIFHDGFRNAAILSRVSPNIHIRNFTQQDMKNEEIMIRHLGHSKHFQMSYTVSDGVHDVPSVLTVIASEPFIRFENHHVYLPPSETDLLLTLTNQNLSAITNFDVGPADIVFFVTHSQNFLIMHNSSEFIAKNFTQKDINDGKIFYRSLVSDLTDEQISVQVDKQIDTVAFRKLRQQSLRRSSIEMRTLSVLVVPISSLSQIDKNILFASAPGKTPSEIIYDVLKQPNSGSLILESVKGIIKQFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PZ26</accession>
    <name>A0A3P7PZ26_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PZ26"/>
    <dbReference type="STRING" id="318479.A0A3P7PZ26"/>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF238">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="279" mass="31158" checksum="D345DBBE5EF139E8" modified="2019-02-13" version="1">MLAMSGIPNWKTIKTDGAIRYIELLLLVDMSTYIYQLNIRIIVVDVVKVIGYNLTLEQIGKYRKQSLTKMAKHDALMLVSRSFDGGIAYVGGICGPNAIAITGFYPQSSMEYSSVIFHELAHLLGVPHDIKTECSCSYELLGNCLKIDGYDNDCSAQALVDNLPWHSCIQSPPEELPATVLPICGNGVLEPSEECDCGPERFCSSLVCDASACRRTISNMQLVYILSFILFSATVLLFFCVKFIANRRDRVFSNNVIKADTKNIWQVLKNYINKNLMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q9P0</accession>
    <name>A0A3P7Q9P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q9P0"/>
    <dbReference type="STRING" id="318479.A0A3P7Q9P0"/>
    <dbReference type="OrthoDB" id="10256043at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="355" mass="40181" checksum="ED35A4F84518814C" modified="2019-02-13" version="1">MRHFQGISENMTALPTIWMGTQNEYIYIHSAVTNWKNCLRRIKIPDAVLSILHYKGRIFAALANGSIAVFYRDQVGGWSESGYSTITIGKATSSVRSLTVVAGRIWAAYRNCIIVIDPNDLTVHKVFTAHPRRDSQVRHMQWIGDGVWLSIRLDSTLRLFHAYTYIHLQDVDIEPHVTKMLGTNQLDYSYMRTTALLVSCRRLWIGTGTGVIVSVPLDEVINGKLETKIPIQSVNDEFRGPGGLIRVYSDSTSDRISPGSFIPYCDMSKAQLSFHGHKDSVKFFLAVPGIESDIEQISDKRTRKMLIVSGGDGYIDFRLGEEDDDSHFKNPRPRDMSHLIVWEVDSKIEIMKNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QA08</accession>
    <name>A0A3P7QA08_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001243">
        <property type="protein sequence ID" value="VDN60773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QA08"/>
    <dbReference type="STRING" id="318479.A0A3P7QA08"/>
    <dbReference type="OrthoDB" id="1601181at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10454">
        <property type="entry name" value="GIY-YIG_COG3680_Meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="197" mass="22800" checksum="012BF957FE1A4314" modified="2019-02-13" version="1">MERMMEGIAYPEGKELNEQIFNHYNVTSKNNRAARTAFCYILIDPSLINNPNTALLKEFVNAIFYIGKGKRNRPMQHLIEAVKATENSYKKNAKIQKIRKLWDCGYGVVSLHVFQNITSKEAFTREAAMIDAIGISNLTNEKRGQYYDIGEKWLLRQKLIYGSYLLSRALEVLHVEGCRQLFESNVEHVITNYAFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SDR7</accession>
    <name>A0A3P7SDR7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sec23/Sec24 trunk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000095">
        <property type="protein sequence ID" value="VDN53026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SDR7"/>
    <dbReference type="STRING" id="318479.A0A3P7SDR7"/>
    <dbReference type="OrthoDB" id="5846198at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="5">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="7">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="4">
        <location>
            <begin position="451"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65891" checksum="48FFD3EC345D8BCE" modified="2019-02-13" version="1">MDHTGRRTDICNRPEQFLGSYEFVATTHYCKNGAMPKEPAFIFMLDVSYSAVQSGLVSIFCRNIRSLLNSLPRESGQEKSSIRVGFATYDQAVHFYNLKNVAEQPEMLVVSDVNDVFVPFVDVDGYSLNFCNFSERLSLLTEIEKMFAETRCTETILGPVIQAGLDALKIILQPGTDFYSKLAEECVKNGCAVDLFLFPNSYIDVASLAPICVITGGTMYKYHYFEGPKDGSRFLADLAHDISRDIAFDAMMRVRTSTGLRATNFCGSFYMDNSTDMEMGVIDSDKAVHVELRHDDKLPDGSAYIQTAILFTTCSGQRRLRIHNIALAVSSEYSHLYRLADPDCLVSFLLKQAEFLVREKTPQEMRDAITHRCAQMLATYREKCNEQVPVGQLILPESLKLLPLFGNCIIKNDAVSGGNDMTVDDRSWMMQMICSLRIEDALLLLYPSVSMPAYIRASFDNFSHDKAYIIYNGIIMFLWIGLQVPQTWIQDIFNSNSVSHLNVENHIIPERDNTSSRGLRRIIDRINSGRARYMKLFIIRQQDALEAWMKKFLVEDRSSAMPSYVDFLCNIHREIRTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SUT8</accession>
    <name>A0A3P7SUT8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ILEI/PANDER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SUT8"/>
    <dbReference type="STRING" id="318479.A0A3P7SUT8"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF2">
        <property type="entry name" value="ILEI_PANDER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="364" mass="41816" checksum="40047337EA0AF6F2" modified="2019-02-13" version="1">MDFECVILVKNIFKKEINDSAYTELGPSDLSIDPFISKKNQMAMSFYSGKDKDDAPKICVNGLRLCKRFDGFLVNICFKDSFSDSTELILFLEKVVVGELIAVVSFDEASNRLSGMAKQIFYEFGSSLIHNIKFRSSWYFVGQKGINGFSPFEDLILSSGVDWAKPINKRMCFSSFHEWIFGFEDSKYNSFNQNTLRRHFCAKYDGYEDFCSGSKPNCKRQFFIFQKVVILILHVKLKITGLNMNNIRLCLESVLAQNGINMQKVIVAYDSAYNEVGDLANLFGGYAMPIENASSYNGKYNYFYFYSEYLIVIKEDVLLLSDFLSFLARLLPQFSDDGSSGVILTWNRNGSFFLYRYYIILILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SW90</accession>
    <name>A0A3P7SW90_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SW90"/>
    <dbReference type="STRING" id="318479.A0A3P7SW90"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="227"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="680" mass="76169" checksum="AC0E702E4AA9EF5E" modified="2019-02-13" version="1">MTVFNFAEVEDDSKILQPIDEALFFSKFPRSSRLQVPPEAEKLKRMTKAAEDENQKSEVRAIKNEDSSLKSVKEKRLQKPVAGVSKNLDLSVQESIKEQSLQTRNKVGINNKGEPFEKKNSKDLKRSVCHSPNKYATGVSPKKQCLDYEVLNNTSMSSTRKKTGSLPWVDKYKPTSLQHLVGQNGEKSPMNKLLAWLRGWYHLHIGEGASVKKARPPPWLSQSDGSSFKAVLLSGVPGVGKTTCAIMACKELNLEYVEMNASEVRNKKNLEATVAELIGCRQMDEFFGKKHQSIIDNDAVGLTHVLIMDEVDGMSGNEDRAGIAELIQMIKTTRIPIICICNDRQSQKMQTFYARMLTIACQEKFAVSKELLDDIIEASNHDVRQTIYNLQLLSYGGKNVQSKDCAVNVFEAARRLLSAETSLIDKQRMFFTDYTLMPLFVQENYPNIGSSKTSKYEALENLRRAADCISLGDIVDKSIRSAGTWSLLNELSMFSSALPAAYMNGHLKVMINFPSWLGKTSSTNKRFRLLRQLSSHCYSKIPNGHSSLNVDYISFLRDRICWPLVDNKVDGISSVIATYNYYNLLKIDAEAIVELAAWPGMKDPASKIEPKAFSAFLKIFSFKFYNLLISLLYSLKNEMALDEEGNVVDLGNSSDDSVVENDENEEIAAPLKAVVSKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U198</accession>
    <name>A0A0N4U198_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED6</name>
        <name evidence="7" type="ORF">DME_LOCUS4725</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U198"/>
    <dbReference type="STRING" id="318479.A0A0N4U198"/>
    <dbReference type="WBParaSite" id="DME_0000036501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000036501-mRNA-1"/>
        <property type="gene ID" value="DME_0000036501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000036501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26268" checksum="F04AD4D568EE0EFB" modified="2015-12-09" version="1">MGGPNVGGAAHLQTVSLLHQSFKNPNWPPNYINADNVLDYFCDPGNVFYDVSSCNQHIRMQSLNRPLHECLQNMQGIQFTVVGANHPLYVIMKQRRNSVNNVTPLCYYYVVNGTVYQCPDIYMFTQSKLAGVVDALRQALDLTRQFNRYNVAKGYFWEFKQSTVESNKLLSFARNFSFQEEYNFKSIEEEEKPLTARSTHFQRTRTDNLLRDLFDKFPPPDGMVCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1Q1</accession>
    <name>A0A0N4U1Q1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase I isoform alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS4906</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1Q1"/>
    <dbReference type="STRING" id="318479.A0A0N4U1Q1"/>
    <dbReference type="WBParaSite" id="DME_0000054601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000054601-mRNA-1"/>
        <property type="gene ID" value="DME_0000054601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14128">
        <property type="entry name" value="STKc_CK1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000120">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN54933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000054601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38069" checksum="D2ED26BB07CEAA81" modified="2015-12-09" version="1">MAGVSANSRDFIVASKYKLIRKIGSGSFGDIYLAINITNGEEVAVKMEQIKARHPQLMYESKVYKILQGGVGIPHIRWYGTEREHNILVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRVEYIHVKNFIHRDIKPDNFMMGIGRHCNKLFLIDFGLAKKYRDSRTRAHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNKGVLPWQGLKAATKKQKYEKISEKKMGTAVEVLCKGCPSEFAMYLNYCRGLRFDEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKASQNSSNAQFGVSGCQDAQSGTFPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2D1</accession>
    <name>A0A0N4U2D1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5188</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2D1"/>
    <dbReference type="WBParaSite" id="DME_0000082801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000082801-mRNA-1"/>
        <property type="gene ID" value="DME_0000082801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869978at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000082801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23183" checksum="2FE82807221806C2" modified="2015-12-09" version="1">MRQNFLKIPPPNCPPPPTEMKVPPPFRNPPVPLLTEKHETRLDESQYDEPGLPSDTHQCAGIGTLSAARDLSERLPYSIGNYEISTSQQWILVMKFVVALVLLVLRTACDVMCCVSYQHSVLDVETYKPFTKGGTIRSTTSSNMRNPRVIASESRSIVEEQLRNSLWDDETRRMLVQNPETGSFYVPTSSGNSNFLFFVLIYKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2F9</accession>
    <name>A0A0N4U2F9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5222</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2F9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2F9"/>
    <dbReference type="WBParaSite" id="DME_0000086201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000086201-mRNA-1"/>
        <property type="gene ID" value="DME_0000086201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="280"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000086201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="78375" checksum="82D04F5E2425D59B" modified="2015-12-09" version="1">MGASETNLLALLPKDFVKFVSSVKWTERRDVLQCFLDNLAHSSRLNTEINYIELMNELKKIIMKDSNVIVISLAIRVLTAIVRGLQGKASAYISLILVPLLEKFKERKAMINCAITECIDEIGFFCNANFLFSSICNVLDNTQNPTVKAEIDHWIYRILLNYDKDRIPFDFIEKIAPYLIQHGSNGSSAVRNGCFMAFGGIIRLIGDQATMAIASVLFADKKKIIKMYSFCEKAAEEFAKLEQMKNSIVEKNSKNNSKDEESFSENKENSRMDSDRNATDFDPWEMLPETNIVLRNDFDTLLSSRQWKERKEALESLLEVLDQNPRLNPGDDYQPLIKSLSSVIANDVNINVLALAIRSVAKIAQALRYKFSSLTPKIMEILLEKFKEKKVILREPLIECIDYLSLITPLSLYVRSVEDALKKENPQIRMQTALFIARLFRQHSRQTLPSIELKIIAPPLLQLAFDSNVDCRDASYSAIGAVMKSIGEKDVGLLFSGVLEDSIKYLKIKEQCDNFLKEFGCCESKAILRLSKIDVENNSGNGSSDILVKNITLKPNTNAKYIRKKDSGFFLPKTVPRSILNSTASHNFHFFSNQISKLSDSSRLIEANRPFTSSRNKQTFPLNCGIVKENIRSTITLSSNNWQETRHLNTTTSVKISQLVKHIAVERSQTMQNRLVRSRPYAPGSKIPRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2P8</accession>
    <name>A0A0N4U2P8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5328</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2P8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2P8"/>
    <dbReference type="WBParaSite" id="DME_0000096801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000096801-mRNA-1"/>
        <property type="gene ID" value="DME_0000096801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824032at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019174">
        <property type="entry name" value="NADH_DH_b-subcmplx_su6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21106">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21106:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09782">
        <property type="entry name" value="NDUF_B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000096801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22753" checksum="670E88E2748FEE87" modified="2015-12-09" version="1">MGTFYHKPAKQGDSPYTRTGLPPPKLKTKIDEPLHRVNEPMSLELYMADEAYRMAGLTPAEREWRGKWLKDQQLHPDEPIQVDAVYRQLNPLRGAYRGTLIRVITPKLLMGFLFVEYIYYVWKYEQKDWQRDTGLGHAYTIRTGIDRKQEIERDNPGLIDRAFPDPSKYRYFDPKFMKHVVHIDIGETNRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2U9</accession>
    <name>A0A0N4U2U9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5386</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2U9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2U9"/>
    <dbReference type="WBParaSite" id="DME_0000102601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000102601-mRNA-1"/>
        <property type="gene ID" value="DME_0000102601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF20">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE_C4-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000102601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41578" checksum="12EAA7543B0A95FE" modified="2015-12-09" version="1">MGQRVSNEDYQWNYTDQPHLNRRKKIIKKYPCIKKLFGIDESFKYVVTANVFVQIVASYLLKDSSWSLVILQSYFFGGIINHGLTLAIHDISHNVAYGNSRPLANRLFGIFANLPIGIPMSISFKKYHVEHHRYLGEDKLDTDLPTELEVHLFATTFRKLVWLLLQPIFYAFRPLIIYKKAPTDLEIINAIVQISFDLLILWLFGLKSLFYLIFGTIIAMGIHPSAGHFISEHYIFFKDQETYSYYGCWNLVTYNVGYHVEHHDFPYVPGRNLPKIRAIASEFYEGLYEHKSWIWVLYQFIANPSIRLSSRIKRKPTTNQQFYDTNMTSNYFTEVSLNLITKILIKSIYSPQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3D3</accession>
    <name>A0A0N4U3D3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5593</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3D3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3D3"/>
    <dbReference type="WBParaSite" id="DME_0000123301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000123301-mRNA-1"/>
        <property type="gene ID" value="DME_0000123301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15718">
        <property type="entry name" value="FYVE_WDFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="295"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000123301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47374" checksum="1FFEA42288E8723B" modified="2015-12-09" version="1">MINLFFVLFLFVKIPHEYKILIKIEIFAELLHKIEGHIARVNDVFLLTKEDGVITISDDRSIRIWLKRDNGQFWPSVHHYMPFAPTSMCFKEDKLRLFIGLVNGSIYEYIVADDMNSLSESRHISVHTNVVTAIYLSLECELLFSCSKDKSLIWHCSQSFVKIGYYNADSTLTAMEFDSPSGFIFVGDSSGNILLLRINGSDAQLISKLSAHTASINALSWDVKRQLLFSAGADFLVITWDIGGKRGQAFEMNAHKSKLTCLCYAQNACRLFSADENGTLVCWDMTTQRLETPEWKSSDNCQLCDSPYFWNLKEMWAKKVVGSRQHHCRTCGSAVCAHCSSNTTRYPPMGYELPVRICNACNSRMQQFPDQFDLTPLAVSCDLRHGIVCMHLQEQIGLLVTVGVDRIMMIWNIRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U439</accession>
    <name>A0A0N4U439_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5889</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U439"/>
    <dbReference type="WBParaSite" id="DME_0000152901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000152901-mRNA-1"/>
        <property type="gene ID" value="DME_0000152901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5802886at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042228" evidence="2">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000152901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18323" checksum="D1F790D5A64DF7DC" modified="2015-12-09" version="1">MKLIRWRSFILWILSTVSAIAHPVKCYCTDDHCVPYGVCESNVCLVGIIRSTNSVIRTCGSELIGCKNNIGRWSSLCSCDEPLCNTFAYLRSNMQKQKEPITDDDDSLIFNRVDSMEYDSFHPDPDATLSTRTSLLTILLVGVPLIVGTATVVVVAFNYYCHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4J3</accession>
    <name>A0A0N4U4J3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOC3-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar complex-associated protein 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6067</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4J3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4J3"/>
    <dbReference type="WBParaSite" id="DME_0000170701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000170701-mRNA-1"/>
        <property type="gene ID" value="DME_0000170701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="436"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000170701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="628" mass="71109" checksum="B60E03C3F89A2C1B" modified="2015-12-09" version="1">MCEFFSVSICDIAEDFSDIETKPRRFKGEPDADFHELLPVKVGGKLVKQSRLINKCDEDGMQEEEKDKSKEPEKQLDYSTLTAAELLAKRKELINSSKLVICNSCYEILADPQNEISKLHELLRYCTGENVHSLAKNGVIPLALASLMQVFVDLIPGYHIRTPTQDELAQKMKKETKKFLEYELAFLKIYVKYLQILEKNVSIFMKGKKESMEESDLTKKAMLSLKCLCRIVLSTPHFNYSTKIIDLIVRLAVCNIPVVKESCSTLGSLFENDIVFETSAYGTGSIAKIVVGKKCNVPPELLSTFLKLKIKEVNNDSNKKREKTRIFGKKVKLHKEKASKSKQKYIKQLKKLEADLKEIEAQESFRKRDKFATETMNHVFVTYFRIIKRMPTTKLLSPVLEGLSKFAHLINIEFFNDIVFALESLVEQQRLRLIDSLHCVYVVFIILSGEGVAINVDPFLFYRLLYRLLPGIPFESDPVVLGRILSLTLRSLNIMFNVRRKCVSPGRVAAFIKRLLAITFLLPCHGVIGVLLSHPNLLSLVEESEGIYCGGNFNASIDDPDYSNAQTSSIIAELEILSKHQHPLAATLACHLRNGLPSVGRSRLNSQIITKLVYCVSNFFINLAILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U509</accession>
    <name>A0A0N4U509_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6268</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U509"/>
    <dbReference type="STRING" id="318479.A0A0N4U509"/>
    <dbReference type="WBParaSite" id="DME_0000190801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000190801-mRNA-1"/>
        <property type="gene ID" value="DME_0000190801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000010">
        <property type="entry name" value="Protein CBR-AEX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056574">
        <property type="entry name" value="Death_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057469">
        <property type="entry name" value="PH_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23629">
        <property type="entry name" value="Death_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25328">
        <property type="entry name" value="PH_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="11">
        <location>
            <begin position="26"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000190801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138900" checksum="C69584C8989510A4" modified="2015-12-09" version="1">MDDKGKELCPRLIDYLVIVGRRSRSKCFSQLSIDGASSSQSVTAPELLRRYPTDDHKDFSLPTDVTVFCQPEGCIIRGAPRRTQSLPDGNSFVFTLTEKDSAKIRYGICFNFFQSFERPKANIDSNADVSNEKKFRRRMSLTSLCLISHHPFLSTFRELLLLLKKLIDGYNFNFRDSVWSALTGHWGDTIPPPVMYEIRELETWILMILSTPVPVPGKTKVQLEVMPLNIVPMLEFALPDHTRFSLVDFPLHLPLELLGIDTAVKVLAAVMLEYKVVLISRNYNAVSMCVLAIVSLLYPLEYMFPVIPLLPSYMLSAEQLLFAPTPFIIGMPASFFSQKNIDSVPNDVILVDLDTNQLIIPESITIPDMPEPDCSILKQSFRNALAKLKLASLDFDLDKGGNDFEASFIVDSDVVDVAVRVAMIHFFNSSNIFANFSEHTRTLRLYPRPVVALQTESFLRSRPNFTQFILELCRSTQAVEYFAESSLCPRNETYVRVQTGIEAPEQIGDKGKWFSEALMPVHFAAYPNDSTLADAWHVFLTAEQKNTLVIIAMLFLFEEASKPLAEVNDIYREPLTLELPRNDSSLSIGSSLSSGRSTPSSMSTSAMDSEADFARLAENLAIKTDAKGIAHLTDSGEKVLGPQLMSALNGYAEKSHDMINQMLHRTAPKAQAFRDKTVGPIAAAAANRMEQSQHLVKTKAKIFNVLSFELSNFSKNQQIVRDVCDQVLAGQGIGVFTYAKLRRLMEDESLRQLVCSKLNLGLDIKHSEEDFVQEMQLMKSQYKGYIKVLQTCINGLDYSFITPGSNGLASMFHILEIAHTHFWAKESDITTPLSGIASQALSISDYSGPFCIEKIFTYGPPPPLPPRPKKSTDEAMKRLSITNDSISVFPLTSRANSLGAIEPLLQLQPPKSLPISRESIVTVNRSPDCPRHYIYQDLILPSPNPLWHKMAFWESAFFDVVAQERDIIGMDQEPCEMIDRYSGLSESEKRRLELDEDRLLATLLHNLTAYMIMCGTGQKAIQQKIRRLLGKAHIGLVYSKTINHLLDHLPQTQSNGIPLKPLGSRLMQKQSFTVYSGSNADGSMMFLEVCDDAVVLRAVTGAITERWWYERLVNMTYSPKTRVLCLWRRHEGKVHMHKFYTKKCRELYSCMKTAMERAAARGKVPIAGKGDLGGEFPVHDAASNEGGLLQVRIDGVYNKYLIAQHNLIHFIDLANIKKCNTFGGNVFILEEYGDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U563</accession>
    <name>A0A0N4U563_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U563"/>
    <dbReference type="WBParaSite" id="DME_0000197001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000197001-mRNA-1"/>
        <property type="gene ID" value="DME_0000197001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000197001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27970" checksum="454053C41558B087" modified="2015-12-09" version="1">MVFCNREFKLSLLNDADYNGNTYNTYILNSKEKGYNSGFDEINPPFLNNNDNFDFVPYEQNNFEVKLKPDSNVVGLLAFQLVGNRTSGVFIRCVDQTSEQSKQLRDGDRISEVCGIDVKKMTCDQIATILRTSLIKNGFVVLKVTAKICKKITQSPKCAIIPNPRMNGESSFMGDCTIKYNKTGQSISECSWESDNLDESFQDYMRLKGLYKRGLVLAQRDLRVLCSVFLAEFSLKSELEYLQQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5G4</accession>
    <name>A0A0N4U5G4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6447</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5G4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5G4"/>
    <dbReference type="WBParaSite" id="DME_0000208701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000208701-mRNA-1"/>
        <property type="gene ID" value="DME_0000208701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000754">
        <property type="entry name" value="Interleukin-1 receptor-associated kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="101"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000208701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43076" checksum="A733DF36DF88BFC6" modified="2015-12-09" version="1">MPDLQLKDVEACRKVYGAGGSPTEILLAIWGSKGNKIVQLYNYLGRIRNIRAMRIIRHLDIFFLFFDSFKFKINMERFSCSTIYNAPSIKYNEVLLATNNFADSQIIGRGGYGIVYKGDWKRTKVAVKRIQSKNNSIKEGLQEMRTLALYRHDNILPLYGFSFDGPEPCLIYQFMANGSLEDYIKCKKTNILTWQQKWNIAIGAARGLHYLHTVGSAPLIHGDIKSANILLDRYFEARLGDFGLSRIGKVSNFSIAANVKGTLAYLPLEFLTRRIITTKLDIYGYGVVLLEIATGIGAFGCSLDESNLASYCHKINSSTKDNSHKNVELIMDHKCPSNDLQHNIYRNLLEMGLKCTETDWNDRPSSQRILDELIYYEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5K4</accession>
    <name>A0A0N4U5K4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 102B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6494</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5K4"/>
    <dbReference type="WBParaSite" id="DME_0000213401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000213401-mRNA-1"/>
        <property type="gene ID" value="DME_0000213401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984396at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000213401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17157" checksum="CFF9E1565CCD900E" modified="2015-12-09" version="1">MFYFLDSMRLFSTTIVRCQHTDWDACEMARLQELNEARQRAAQMEKTMRWWSECTASWRQKWSTVRDERNRSREEGYLLRIALEEAKVNYYSKCLIIYYSASHLNIPTPTPTITIDEECQAKPDTVSTMVNTDQEVKIFPKLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5N7</accession>
    <name>A0A0N4U5N7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6532</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5N7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5N7"/>
    <dbReference type="WBParaSite" id="DME_0000217201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000217201-mRNA-1"/>
        <property type="gene ID" value="DME_0000217201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="370"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000217201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="765" mass="88124" checksum="1F350456C0DB19BD" modified="2016-06-08" version="2">MEKLIDELNSTNVKLRSYQIDGIKKILNWYENNRGGIIADEMGLGKTFQAISILSILINQRKLKPHLIVCPLSIINQWRDEINKFSARKLKVVRYTGNCDERDAIRKKLNETSDWQILLTTFQVFYVLFLTTHMLLIFFIYSAQLFYLEFYSLIFSNSEHKALHGYVLKDAAIFFYKNAWESLVFDEAHRLKSSDSMLHSIIQQLSIKFIILLTGTPIQNNIGELFSLLCLADCKNFSIDHKDAFIMKYGDAKNQQARAELHDIINSYMIRRTKEEVNIDIPNCMQTILYHGINNLQKKLYRAILLKNYEFFDSLECQLNKSSDKYKASLLNVLMQLRKCVAHPYLFSGVEPEPFEEGEHIIEASEKFVILDHLLSILYVEKHRVLIFSQMTRLLDIVQDYLNYRGFSYERLDGSVRDKERFIAIKNFESNSSDSFCFLLSTKAGGIGLNLISADTVIFMDSDFNPQNDVQAASRCHRIGQTKPVKIFRLVAKHTVEEMIYFRANKKLQMANKLMETNSSHTEDKLTAAEITDTVLHGLSHLCEATNKFSISQNDIKKLIGETDANSHWIIPSVQNSYTNNKTENENVDNIYLFEGRDYKKEREVLKEIIESAKNELINHNKPYKSNGFEKQMKISLKKLRKPLAKEQIEAIVQKRYTSLSLPAISSISEESNDIESFDSYGPYFITGDVTKPQRSSSDQFNHFIIAHIIDNSGIFGNGGVFTALRKKNISIVNAYHMASKMKDLSLGDVHLIENISNSRHDSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5W7</accession>
    <name>A0A0N4U5W7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6634</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5W7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5W7"/>
    <dbReference type="WBParaSite" id="DME_0000227401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000227401-mRNA-1"/>
        <property type="gene ID" value="DME_0000227401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="9">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000227401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21577" checksum="E95344CC3B707718" modified="2015-12-09" version="1">MASDHALKRLTLVAVGARLISNGESYHVWKINKEKRERLANFGRYTAECLPKFIQKVQFAAGDELELLIHPTGVIPVISFLKGNHSAQFTNLIFICGVDVPTRKNRFEVIYSLLSTRFNARVRVRTYTDEVAPIDSITSIFRGANWSVFNFKHNIKSNLEELFSHHPLAFQKLKLWCTPFYLGNYGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5Y3</accession>
    <name>A0A0N4U5Y3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6652</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5Y3"/>
    <dbReference type="WBParaSite" id="DME_0000229201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000229201-mRNA-1"/>
        <property type="gene ID" value="DME_0000229201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000229201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8805" checksum="7FAC82C20AC71C7E" modified="2015-12-09" version="1">MADKKNYEFHWDPKDMKTKTLGHWEGRTVQVVYQFKRNGSSLPLAETYLPLKHRGKPECFYSEATICECISSLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U689</accession>
    <name>A0A0N4U689_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal transducing adapter molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6781</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U689"/>
    <dbReference type="STRING" id="318479.A0A0N4U689"/>
    <dbReference type="WBParaSite" id="DME_0000242101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000242101-mRNA-1"/>
        <property type="gene ID" value="DME_0000242101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11820">
        <property type="entry name" value="SH3_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000242101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38835" checksum="0D1196587B319994" modified="2016-06-08" version="2">MPIFGEATSPYDEIVEKVTAETCTSENWALILDICDRVSADHSKGAKMCLLSIKKRLNHRDPHVILLALSLLDSLWNNCDSSFRREVSSREFCQELGSKATHSNRSVGEKTRSILKKWAENECKKDPSLGLIETLYKNLLVEGHSFESDQPSKPSNVNMDPDVVQNSEEEAAIARAIALSLDESSRVPVSSLYPSNISDSIPREVRALYDFEAAEDNELTFMAGDIITVTDDSDVNWWRGKSHRGEGLFPANFVTSELNEPEEIVPVARIDESVLIECLRLLEDCDPTGERPDPPELNDLEYRSLAQGPLIDARLAEIDRQHNALAQVDIAIRDVLAIYDQAVQQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6M6</accession>
    <name>A0A0N4U6M6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6945</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6M6"/>
    <dbReference type="STRING" id="318479.A0A0N4U6M6"/>
    <dbReference type="WBParaSite" id="DME_0000258501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000258501-mRNA-1"/>
        <property type="gene ID" value="DME_0000258501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="567"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C RNAse" evidence="2">
        <location>
            <begin position="699"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000258501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="931" mass="108121" checksum="FDEEE42F33355ED1" modified="2015-12-09" version="1">MLNDGSGESSTLTKEKRKLIYGRTALEEPLNTWICLLKDIWRKETDKALQLELSQSILYEIFDGNENPFEAFISLYRASESSDQKRATLCSIIVKNFGSWLEKCAYKDELYKKFMNQELKELAFSVGTHKSTENLETFIDIFEMNDLRMINHVYYSIKEMMELNNYLNAVKCAIVFKLESYFTIQELAVPCILQDLSILVEKLLENNKISQIELVKYFDQFIGLSKTAANIAPRFIKSRQESSLRYIVYQRFKNAEISEEGYFDFVRHAMQNRELQIYFVNYLVDVRQYEDAVFWTIYCNMFRKPPRKVLPYLNDNHMFVQAQEKITKLNANLAPNLDKLELFKGHPIKMIDTIVKLDQFLVILQNSPIIGYDSEFKPSFLSTEVEVRRHMTDSSKVLVQIALIQISVPDCSYLLDVIALEGIMQDWQWLHLFRLLFCREESIVLGFAFQNDIHALCSTFPVFKQIQHEIRNVICIMRLLLRENAAIIGRNNAESFVKNNIGGEFCHERNDAINQSFSGVKNEFNQCEPADNEVNQCELIEEVNQCELADKGVNHCEVADKKVNQCELTDKELDVSSSDKSFHFRLTDLCRWILGEDLDKREQIGNWAVRPLRMAQLRYAALDAFCLIKLYEKLKVKAIELSMDWERHINIGCINAKFTGIKKPKKKKKCNEERFQEAIARVNAYQDSFQNIRGPRDVKIIVDTMFLGLGKHLRRCGVDTLLAYSRDELIGFAREDTTRIILTCGKSFDQLNSRSSNSGFGKILCVPSHNSVFQQLENVLKILKLRLTREDIFSRCMNCNSNIFVIAPAPVLEALYYMDPKNLYRMHNSFFMNENEKYFSKIRKIDPNTYSGYGCKLVVDINTSSAVAYCYNGLIDLSGGLVKSNKSDYPVFMRYQKFPPNVYEEIGRYFFSIYLYSSFFKVKSISVESNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6N1</accession>
    <name>A0A0N4U6N1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6952</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6N1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6N1"/>
    <dbReference type="WBParaSite" id="DME_0000259201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000259201-mRNA-1"/>
        <property type="gene ID" value="DME_0000259201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="188511at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000259201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25314" checksum="112E2223776CB0EC" modified="2015-12-09" version="1">MHFKNSCKNCILLLEMQALEIGKNHKFHSCADINIIQQGDISNEYNCLVDKDCQNNGKCIEKSDSFLTKSCYCTIGYFGKNCDRNFFSNVSFFNSEIEIIMDYATNSWVALGWKPMNLPTSCRLFPNLEYAKFDVAKMQKILNNMAVQKIMDFVSLFFETALNAPLHPMDCTDIVVGSIIDGRLQINDINDIQENRSTPLDDTWFHDGRTIITFRRQIAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6X8</accession>
    <name>A0A0N4U6X8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7071</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6X8"/>
    <dbReference type="WBParaSite" id="DME_0000271101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000271101-mRNA-1"/>
        <property type="gene ID" value="DME_0000271101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000271101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11194" checksum="9A9FCAD15070A1DA" modified="2015-12-09" version="1">MLRLGLFDDKKATGIVPPNQSSYIKFMKHSGWKKRSTSTLTEKQWLNALTDKKNEAILLAGNGSILHYTQTQNVQKEEEKRDAHATSWEAGNCLLTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U773</accession>
    <name>A0A0N4U773_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS50</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U773"/>
    <dbReference type="STRING" id="318479.A0A0N4U773"/>
    <dbReference type="WBParaSite" id="DME_0000282101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000282101-mRNA-1"/>
        <property type="gene ID" value="DME_0000282101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000282101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="685" mass="81956" checksum="98341BBCC0B4AD3B" modified="2015-12-09" version="1">MPQYFDNEIPYFGRKSSKDLKIYRNSKQKIAPDCVMKCLEQQPFWEYLSSDGTVNNDFLQVHNYYKKQIIAASKLFFDRFHIAYSIKKKKNWKLIDETKRNISGIQDERASLLVMVVKVNSSILYQSEKFVNTLDHVPVDEIHLIDVKKHEIHMKTKDLLYGEIFHPHKAIRQNVPSHVWYKKRISRRYHPAPILNLSVFGLSDKVVVVLKELISKYSNRWLNMDKKWIRKYKYNEKNGRKKKERKDRRFDQYKNFFAFEYEGNVYEPFDEDFIEKWFLKPKINDTSQFYKEKDIKKNGMKKERKDYRNKKFFLLKYQEYESYNEDLEEIQFLEQEINEIFPTLHESHFCTSDFFVDRSSVLKSKRQRKGKIPKIRSKEFEQWFSDNPAHELHEDGFVDDEKRRVIDSKQNNVFSYVPLPLYNIFLNQQEAEFVKCRLLPNTQPVSNIIPISYTVDFNWRHNPHLELPEFLKNYYGSIIIQPILYGSSQREFLRIILNPFTSEDDKFDEDVKSSLLVSRSSFEKFLPRTVQLHSYDASSACCIFLQEMFLTEYEDQQDELCLPSYDSDFYCSVCGENDKYKYGFALQCKHYFCADCWGQYAVERISLARVPVLCLKTFCNEKLSLDQMRIFLSSKICNRYKNLLFNKGMMRKEWTYCRKCSKILHIPECSKIEKSCGICKCGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D0</accession>
    <name>A0A0N4U7D0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS118</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7D0"/>
    <dbReference type="STRING" id="318479.A0A0N4U7D0"/>
    <dbReference type="WBParaSite" id="DME_0000288901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000288901-mRNA-1"/>
        <property type="gene ID" value="DME_0000288901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="14">
        <location>
            <begin position="82"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000288901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="596" mass="68601" checksum="84E946E85F7F4B17" modified="2015-12-09" version="1">MNRIIPKSRRNRLLLIILLFIVAWFCLYPLEAFIFNFSDINQTSVKIFNVVNCSLNGMNLTTYPDCIAKIHWMMKNWKTDICYGQNGVDGSLCSIYIYLSEIERHCPLLQRQLSSFSVPNMKNLFSLMHDSNINYEFIKKRIKHLWNKWIEAYEMNSAKWPQSLPKRRLNIILHLGFLTKEAGLKFGEKSEFGGPLGELVQWSDLIAALYILGHNLSISSQCYTNSFYKHVSCPNKSARKFDLIFTDIIALRYMRRKMKAFFLQNSCIFRVLDSFGTHAEFNNNVYYLAHKQELGGTKNPWGGNGLKLKQFLTMYPHTDDNSFLGFVVETHTDKVSPKRKNATLVYGKEIYMWENAKLLLETVGKYTQLHATVNYSMENYTVVNHGILSGDKLHSLFKSVKIYLGLGFPLEGPAPLEAIANGAIFINPRFNPPKSRRTYKFFSEKPTLRELTSQNPYAERFIGKPYVITVDIKDMNEILKFFLFRFSLPRSYIPFEFTTIGLLQRLNVLVNKQDFCLNSDFPPKKAAIILDAKDGHFRSSCSHLSNVSSPFAPYNCKLQMENSLFSCASKPARGISRICPCRDYINGQIALCSLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Q2</accession>
    <name>A0A0N4U7Q2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7182</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Q2"/>
    <dbReference type="WBParaSite" id="DME_0000302301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000302301-mRNA-1"/>
        <property type="gene ID" value="DME_0000302301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000302301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9779" checksum="954F1E0E2FDD9CE2" modified="2015-12-09" version="1">MKKKGELERKFGEKLRKLIDLKRNYVKFLGYSECKTKITARLMMADNPLPKIWEKLLRLGFQRYSRGSLDDEHCNRFMPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Q5</accession>
    <name>A0A0N4U8Q5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS306</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Q5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Q5"/>
    <dbReference type="WBParaSite" id="DME_0000344001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000344001-mRNA-1"/>
        <property type="gene ID" value="DME_0000344001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="107"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="289"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000344001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61407" checksum="A5B5F789935B95C5" modified="2015-12-09" version="1">MVNVQKKILKRKLNKLKDSNSTKKKKNLFFEEEKNEESEQTFSKLGSGDKIEKNVDEGEKIGEKLDASTYLSKTRFDSLSGCLSAATLSAVKEMGFTYMTEIQAKCISPLLEGRDVLASAKTGSGKTLGFLIPAVELLVRLGWKTWNGTGAIVISPTRELALQIYGVLTEILGKHPALTHGLVMGGANRQAEVKKLCNYINFLVATPGRLLDHLQNTEGFMVKNLKCLIIDEADRILDIGFEQEMHHILRLLPKRRQTLLFSATNSAKVEGLIKSALNSDPNASATVSGLQQGYVVCPSDKRFLLLFTFLRKNRNKKIMVFFSSCNSVKYHHELLNYIDVPVQCIHGKQKQQKRTCTFFSFCQAKIGILLCTDVAARGLDIPAVDWIVQYDPPDEPREYIHRVGRTARGEAGTGHALLILRPEELGFLRYLKQAKVALNEFEFSWAKIANIQLQLEKLIEQNYFLNKSAKEAYKCYIRAYDSHSLKTIFDVNTLDLIAVAKSFGFTVPPFVSLPFSGKPKVTFRSKLSGAGYRRKMKAFCQIKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9H6</accession>
    <name>A0A0N4U9H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7750</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9H6"/>
    <dbReference type="STRING" id="318479.A0A0N4U9H6"/>
    <dbReference type="WBParaSite" id="DME_0000374501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000374501-mRNA-1"/>
        <property type="gene ID" value="DME_0000374501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000027">
        <property type="entry name" value="Protein CBR-LOV-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="197"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000374501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36940" checksum="D8ACF808FB7E4520" modified="2015-12-09" version="1">ILDIHSFRTTQWNSSIFIEFSKGLGRKYEGEIWLFVAYQSLPGPLPHDHQWRFLVQKQTGINFYIINANELNNKMGLYFIGVGCAVPQNSTKNKTNLVEYRYGGNDVKYFERKLPFQYSIRIFTKGCFFYDEEGGLFRNDGIQVNKFVFSCATSHLSVFSSGTFRAKVPEFFSYEYITNNNEGRIRYMKDNKFHSEYKYLIAVETGYKMFATTDSHIFVNIIGTEGSELVRELADDFCSKCQFSWGTTERFLLKAEKSLGSLKALRLWVDETGEMYRQSWFCNRIIIKDLQTDENFHFDVDNWFGTLNGDGEVFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA44</accession>
    <name>A0A0N4UA44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA44"/>
    <dbReference type="STRING" id="318479.A0A0N4UA44"/>
    <dbReference type="WBParaSite" id="DME_0000399601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000399601-mRNA-1"/>
        <property type="gene ID" value="DME_0000399601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000399601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20292" checksum="2A86D9881A1353ED" modified="2015-12-09" version="1">MDSEKEEKDLNDDNKLSNVFNERKRRLAQIRASCNQGGFFIHKYCAMLSCYYVCSENHSESQLNGKKLQSKNCEPVNEGNRMKTSNVDLFIVEREIKKQLLDTEDTSVVENVDITTLAPKKIDWDLKRDVAERMEKLERRTQHAIARLIRQRLEAGKTGLDIAVNSGAYSEFQSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA66</accession>
    <name>A0A0N4UA66_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PG_binding_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS387</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA66"/>
    <dbReference type="STRING" id="318479.A0A0N4UA66"/>
    <dbReference type="WBParaSite" id="DME_0000402301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000402301-mRNA-1"/>
        <property type="gene ID" value="DME_0000402301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidoglycan binding-like" evidence="5">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000402301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18068" checksum="BDEAD9C4D89BB925" modified="2015-12-09" version="1">MAEHDRIIHTNMSFYYAYYHNGFVFSRNCEQFNIKYLEDFGYLAKSHGASAMISQTIVDEALRELQHYGNIPVTGRVDQATLDLLSRKSRISHFNFGNALRCGLSDRRTNRRRRHRKRFSLMGMKWEKKMITYSEGSEQLLNSCRIVEALRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAL4</accession>
    <name>A0A0N4UAL4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8083</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAL4"/>
    <dbReference type="STRING" id="318479.A0A0N4UAL4"/>
    <dbReference type="WBParaSite" id="DME_0000420001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000420001-mRNA-1"/>
        <property type="gene ID" value="DME_0000420001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795596at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000261">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF189">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="178"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000420001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35667" checksum="AA4D9FF3E0FB6B0E" modified="2015-12-09" version="1">MASLLRKLFGAHNKKVTQKDSITGRNNSFPVPYLSKLEGNQLQPGQSLIIRGYIIGRSEFIVNLTSGAKVEKEDENDTLDNRLLVLRANITEKKVYLNACIDGHWGREGSVKHKWSPGDEFDIRIRSHDKHFEIFIEHKLMAKFTYYIPITHISHIYINGDVELYSVSWEGKYYQIPYAADIPANFYPGRKLYISALTRKRAKQFTVDFHCGSDIAFRFNPRIVEKKIIRNTRCDDRWGNEEKSSEAAFPFRRKRTFDLLFYCEENRFVYYVDDCLIGTYNHRLGPRDIDKLSIDGDIDLQGVHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAS5</accession>
    <name>A0A0N4UAS5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8154</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAS5"/>
    <dbReference type="STRING" id="318479.A0A0N4UAS5"/>
    <dbReference type="WBParaSite" id="DME_0000427101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000427101-mRNA-1"/>
        <property type="gene ID" value="DME_0000427101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25374">
        <property type="entry name" value="Cadherin_FAT4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="99"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="210"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="327"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="431"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="536"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="641"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="748"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="845"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1045"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1161"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000427101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1668" mass="188308" checksum="A18526D26A1A29E4" modified="2015-12-09" version="1">MVFTFTERQLYFQIVEGVPAGTLIGKIHPEAGVRYRINGRSNYISFDSDTGELRSSVVLDRELVAPNNSLDIVLVTQPASIINIHVQILDINDNDPIFPLPFLNISIIESAAIGSRYTLQSATDLDFGENGTIVEYKIENSQSFFKLIHLKIPNNNDLLFIELLKELDRETKDFHVLNISATDGGQPPRFGYTTIFINVLDANDNAPVFDRSHYDVVLKHLDNPSDPILSVSAIDYDTGDNARITYRISNDQHKQFRIDQNNGTVFLQKSNLNCSRTGCQENCSRMCVIAIEAEDHGSPKLSNRAFVNILLNETNDHDPVIRFRMYPPNLDFAAINEMAAIGTTIAIVTVTDDDFDQESRVEIIDGNEDGYFKLERGKNFAILRLNRALNKQIDQFKIRFKATDNGVPCRSSVRDLEVYILRDNDQAPKLMEDIIEASIPEDAIFGSFVTVVRINESPDRRGFLFTIKEDEGVDGLFKIGRSSGIVTVAKQLDNLKNISKITLTAIVRNARPNLKTASCTINIKIIDVNNHWPTFEQQIYTITVLENTPLLSVIGTIKAIDLDRGNNGLISYSMAKNGATKEVSVKEKTGELVLRRVLDREQQSQYTIRAKACDHGNPVKCSTTDIVIKVLDINDNAPKFTLSEYYGTIGRTDLPGTKICRVQAIDYDDGKYGDVYYLLYDSPAGLIDIDNSGSLYLTSYVDKYAKLEEFRITVGAKDGGDLLSSNNASIFIRITSESHESHTFPSIFGENQNLKVKENSPPGIILKKFSFHTKNNDVRYHIADSTFLQIDQYSGELRTKQSIDREKLYNNISFTVFASIKNFTATYSGHLIVLDENDNAPQFEIDSTTKLVIRSDTIVGSEIHRFFAKDADEGENGRIEYSVDSDFFNIDAQTGVLSLRKFVENLDQIQFKVVARDHGIPPLNASSKVTAVIGKNENVYSFPPKMVFKVSEDASAGTIIANLMPIDFVQSCIHEFRPMVEKTLNSSVWILSSGQIYLEDNVDREIQDKFIIPVDILTRKHGIESKRKTIIIVYIDDINDNLPQCPNDTKFHIKENQPPLSVIGAMNAIDYDEGINGTLFYRLKEKSEYFFIESITGIIKSLVAFDFESKSLYFLTIEIIDGGHLKAECLVEIRIDDVNDNYPETKTEFYHFQADFGNYQIGQVIATDKDHGQNGIIRYHLSNIGLPLKLLIDSLFQIDEISGEISHNGNLKAGEVYNLTVIASDQGIPSLATTILVFVHVPERLDCIPEFKKFPKTPIIIPENQAIGSMVAEIQAIACRQHVKYFIAEGNHQNIFEIDPYDGILILTGFLSFGNSSLYHLEVVAATSISNSSFFLDIIISDPIIDYPVIETNLIHIQENNEAGKVCGKVLVTGLVDKNLIIMEIIQQIPHGQIFRLEDENLICEDILDRETANEYQLFVRAANKRKRDRKMEKSIKIIIGDENDNPPFCKGVDNFLISDKAYNIEWNCFDVDEGLNSSVGYYIPEENAPFISEYSSKLIRIQPFDGKPRHFSAIIFDRSTKHNNLSTMDHLRRSIERRFTIIPHRPSSKIRFAQSKDFFEIDSETPLGSIFGSVSVETNSSLEYFITSFRERNVDALQFIDIDRRTGQLRVIRKPNASQVQIEITVVSDGFTNSKTVSIFFFHYSKLMAKLNSPSFAVIYDLLYTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB20</accession>
    <name>A0A0N4UB20_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8262</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB20"/>
    <dbReference type="STRING" id="318479.A0A0N4UB20"/>
    <dbReference type="WBParaSite" id="DME_0000437901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000437901-mRNA-1"/>
        <property type="gene ID" value="DME_0000437901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125004at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000041">
        <property type="entry name" value="insulin gene enhancer protein ISL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047169">
        <property type="entry name" value="ISL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204:SF8">
        <property type="entry name" value="TAILUP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000437901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28334" checksum="C82FF177482FF0DD" modified="2015-12-09" version="1">MVTLVTFRGVGLYRKKCRRCMKLFERVDLVMHAGPLLYHVSCFSCHYCDKKFITGENFFVNNDEIYCGAECIDARPSSTKTEIFVRDDDDCWDSSTLTSLDNQMTTTPPLSLRSPRSDEACETIEIFPKRIATCFFEHHLNVITFPGPSSASVSTGSMKKNKKDKQATRVRTVLNEKQLMTLKTCYAANSRPDAIMKEQLVEMTGLSARVIRVWFQNKRCKDKKRQQALRHLQQRAETASHFDNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB22</accession>
    <name>A0A0N4UB22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8264</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB22"/>
    <dbReference type="STRING" id="318479.A0A0N4UB22"/>
    <dbReference type="WBParaSite" id="DME_0000438101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000438101-mRNA-1"/>
        <property type="gene ID" value="DME_0000438101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872223at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF236">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000438101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="32233" checksum="AF2A7967FBA65273" modified="2016-06-08" version="2">MGTHLLVNIASAASGAIIVVSLITVGMIFQDINSFYYDVLGDMNDFKTLANDAWDELMMINSARKTENAKRPSVFETLTGKRRDKRQAHCACALQPVTCPPGPPGPPGLPGIPGEPGERGEDGRPGINGIAVMYGPDTRGGCIACPAGPPGPPGLDGPPGPPGPDGLPGIPGNHGFPGPPGLPGPVGDQGPPGPAGSIGPAGPPGAPGVVSKGTPGPKGPPGPPGLPGKQGANGAPGLPGAQGPMGPPGQPGLPGLDGKPGQPGVPGTVGVPGSDAAYCPCPPRSVQTAAIVAEPTYRQSDQYSRHVGRHRRVRKKYVSRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBB4</accession>
    <name>A0A0N4UBB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase S10, serine carboxypeptidase, Alpha/Beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8367</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBB4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBB4"/>
    <dbReference type="WBParaSite" id="DME_0000448401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000448401-mRNA-1"/>
        <property type="gene ID" value="DME_0000448401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5812398at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039177" evidence="7">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000448401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46486" checksum="2DA4E3AB4BDC5B97" modified="2016-06-08" version="2">MFAAILVFFNIVVTVYSESPINLPDSPDNDVVQYSGYLDFDNNQVHYMFVLAENDSSSSPVLVWLGSSPGCSLLYHYFEFLGPYIIDTNSNGSLVRNNNAWSKIGNLLVIDNSINAGFSYGRTETPNVYRRRDLTYKALLRFFEIFPQFKGLFFGNAILDLNELTTDRTIFMYGHGFLDERLYQIVRQNCCKGVMEECNFLQPFGDEFCRNAAFYLTSSFLESSLNIYNMNQKCKNNSQITKAIRDIRNKITTIAEFMNSFAAQMDVECVDETPFASYLNRADIRQALNIPENVKPWNIIVNYNSLLPISNYYAMKMVVNSGIRLFFYSGDSCLMAPMLHSQKFASKLGFEKTSAKKPFSIEKNRVAGYHTQYGLIDLVTILRAGVYAKERPAEALHAMNAFLKGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBE5</accession>
    <name>A0A0N4UBE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nkap_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8404</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBE5"/>
    <dbReference type="WBParaSite" id="DME_0000452101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000452101-mRNA-1"/>
        <property type="gene ID" value="DME_0000452101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000452101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23636" checksum="9C523D42E2792764" modified="2015-12-09" version="1">MKNGNKSKEKKKKQKEKKKVNLKFTVLSCFAKQFFMLFHSLIQKKRDSSDSEEEWVEVTAEMRQAEAAREKMEEASMIGPTIPEHLLQKEFVIDHSKKINYGKDMLRGEAAAMAAYVAQGKRIPRRGEIGLSSVEISEFEKIGYVMSGTRHKSMEATRLRKENQVMTAEEKRLLSGFTHEERKKKEEIVLQQFRSFIESKKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBS6</accession>
    <name>A0A0N4UBS6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8562</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBS6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBS6"/>
    <dbReference type="WBParaSite" id="DME_0000467901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000467901-mRNA-1"/>
        <property type="gene ID" value="DME_0000467901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000467901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27698" checksum="EC325D24019F05FC" modified="2015-12-09" version="1">MADLERSDAAQFDPPSLINRTLAERFFSALTSFSIPDEKSLQRASKSFSKCPDDEIEQYFEFVASFGKPCFKWNIIRPAFLWKLEQVMLEMRKVEFENLEENAKVALIAADEQLKNQREFIMRKAREFEGTPFTIQRLCELLTTPSRHYKQTDKFLRAIEKNINVVTCITETGERITGVEDFPLDDDDCYQRIEQPFFVKVYYIVDEMDIDNSVVTPLSEENEYVSVSLPAFFFLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC23</accession>
    <name>A0A0N4UC23_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8675</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC23"/>
    <dbReference type="STRING" id="318479.A0A0N4UC23"/>
    <dbReference type="WBParaSite" id="DME_0000479201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000479201-mRNA-1"/>
        <property type="gene ID" value="DME_0000479201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000479201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15755" checksum="47594DEC3E94EFBE" modified="2015-12-09" version="1">MLCNAEDSTRHAENVRRKLESEIRNHKIVLYSKSYCPFSRVVKRILDGYQINDLKVIELDYQQDMSLMQDHLKEKTGIRTVPQLFIDSKFIGDQRTVKAMENDGTLENVMLRAADPFTKDLGIEIQAGPQQPPGFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCN9</accession>
    <name>A0A0N4UCN9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8841</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCN9"/>
    <dbReference type="WBParaSite" id="DME_0000504201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000504201-mRNA-1"/>
        <property type="gene ID" value="DME_0000504201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5774963at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057449">
        <property type="entry name" value="BPTI_C_nem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25315">
        <property type="entry name" value="BPTI_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI-like C-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000504201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12186" checksum="C546E95115B81708" modified="2015-12-09" version="1">MNLCACPIGSPARGCDPMPFILWHDLIVNGCPNVTINTRDPAQKVHRWFRRVNRFSNTDQCEPYVFPYCPELDFNLWRSPKTKQECENYCYSLSEQRKRGTIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD07</accession>
    <name>A0A0N4UD07_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8978</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN59005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD07"/>
    <dbReference type="STRING" id="318479.A0A0N4UD07"/>
    <dbReference type="WBParaSite" id="DME_0000517901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000517901-mRNA-1"/>
        <property type="gene ID" value="DME_0000517901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000056">
        <property type="entry name" value="Zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="107"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000517901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="51283" checksum="D7283C8FA7C02475" modified="2015-12-09" version="1">MHQIFPRNENDLTQLQKLYEESDKVNFWKAPSKINKSVDIMVPQVEKRNFLDFLSKHHMTSTIVVKDLVKLLKAKEFDLRSQIRLRYPNERRLNDDYSRKLYLRMGEYYSYVEISWWLKYLEQKFPNLVEVISIGKTYEERSIYGVKIGAKKREPSRIIWIDGGIHAREWASVHTALYFVNELVSGYENDALITKYLNLLDFYIFPCVNPDGYEFTRTDQYDPAIRFWRKNRSPQKCFAHNGSQFCCKGVDLNRNFDFHFAEVGASSSPCSEIYRGENAFAELETKAIRDKVLSIKDRLDAFITLHTYSQLWIYPYSHKKNAYPSDVNDLKNVAKQAVESLFKLYGTMYRYGTGPETIYAYSGGSSDWVKQNTPTKYTYTIELRPSSFNWNGFVLDKRQLIPTARETFEGVKVVIDKIIEEHKFDPRKSIFNDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDP0</accession>
    <name>A0A0N4UDP0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS564</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDP0"/>
    <dbReference type="STRING" id="318479.A0A0N4UDP0"/>
    <dbReference type="WBParaSite" id="DME_0000545801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000545801-mRNA-1"/>
        <property type="gene ID" value="DME_0000545801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000545801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="27125" checksum="F6B4F221E1E53FDE" modified="2015-12-09" version="1">MDKYQTQAKSCIEVVIDFSRPDGQRTRPLLVDGKRLYVDEHYISIWSPILRAWCIECPDRELILANVQYDHVLEMLQCIHPTYKDVDDQSVHILLPLAFDYQMEGLLHRCECFLVDHKLPFLEKVWLADRYKLNRLLVLCLREMKPNCKIDLTGTRYYGLSDRVKVLILERLHGSPAPDEMLEQPIDLENLQRVSDLNFALIRAKTGRPYYINPYYIAAWSNIFFVSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEH2</accession>
    <name>A0A0N4UEH2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS773</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEH2"/>
    <dbReference type="WBParaSite" id="DME_0000577901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000577901-mRNA-1"/>
        <property type="gene ID" value="DME_0000577901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000577901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17510" checksum="B4EE8C94351A4A69" modified="2015-12-09" version="1">MYTDEGEGESNDGKKRSTGECQQPPGGSQQPVVKRVAVKKQLLEARKQSGCAKLQIKTNSSYTSKTPDPEQGLIERETSSASRTSIKNLTNPQIRRLLYQKLMSIKRLTVFSKQHSGYYKGFDSDKLRVEKMGNVIRQFRLSTTSCFLNANKAVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEH5</accession>
    <name>A0A0N4UEH5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bladder cancer-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS776</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BLCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEH5"/>
    <dbReference type="STRING" id="318479.A0A0N4UEH5"/>
    <dbReference type="WBParaSite" id="DME_0000578201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000578201-mRNA-1"/>
        <property type="gene ID" value="DME_0000578201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772623at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000578201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10999" checksum="892A828946D2F5F1" modified="2015-12-09" version="1">MYCLQWLIPVLLIPKHWLHPTFLIDQAIFMCFYVVGFFMERRPCYICSLIFFTAVGLLCWSDSDSCIFWPSCKTVFNGEMCSYVFEDKRWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES2</accession>
    <name>A0A0N4UES2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUPID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9418</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES2"/>
    <dbReference type="STRING" id="318479.A0A0N4UES2"/>
    <dbReference type="WBParaSite" id="DME_0000589401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589401-mRNA-1"/>
        <property type="gene ID" value="DME_0000589401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="849" mass="96046" checksum="5DD23C9E3DA9CF45" modified="2015-12-09" version="1">MGRRKLPSIPTQRTEKASSEQPAPVYLTSSNISLPSSPSERQYFLQDTNRSRPASRASSLSDLSRSSITTASTYRGVDPAIIPGAVIPNVRQKTIRQTTSTATGGRSNTLGQSSSRMPSTLARVLLKKELKEVLERRREALEACEIEANQREFVVHRMLITGLLPEHRSADIDDIPNVIHCLLPVELVNGAKIVPSGERSTNTSPLSLSMQTDETSRATQGNDFVSKIENAVCSDDLEKPKVKSIAIQVEYKPHKTKQFASFYRPSQLCSSLSAPKTPQEAFITTKSKFQSTGTQTNGITSNHYESSHKSPVTGRSHEATNSGDTYVSSSEPNLLESTAKYFAEYDRQLREHGRRLKNRFAFSDDDPISRESKKQRLISELAQRKEKISSMADLSNSLNHSDYSSTVPHYGSLPIIDFPASSTTHSLKIPRDFKKHGKIRYGSLPRNYERHMDNCAYEPSCNSIQPFGIRQYDVLSRSLHDLSRSYDDISDPRIRIRNTSSFNHLPQNDAYDVCHGIRSQFINDSCGRHAYPEYLSLEDAQNPMEADMISQYANYLSNEFMNNQRKLLAEYGTDIPSAFQRDTVRTEPYPNFVNVYGTAPSNLCPDRAIYIKRPLNEYEKRTFISNHSASPILRSNFHPIHSIQQSSYQPVAASSQMQYPFMPSVNYVPPTGSNTTKFPPYFNEVYSRNEVNYGSRPLYSLPEYGNFHRNRFLKESDACFNGNFGPLLEIYGNSPENHGALRDQQYRPYFAQNAQNLQYSYKPITNYPFPLDQQIEQYSMGNNRRFGNLSCNYGRAWLSNGNLPMSTYYDAIYPKENAKGNFATTSRLRPFRSYQTGNPSVLTAQMISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF42</accession>
    <name>A0A0N4UF42_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS974</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF42"/>
    <dbReference type="STRING" id="318479.A0A0N4UF42"/>
    <dbReference type="WBParaSite" id="DME_0000603501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000603501-mRNA-1"/>
        <property type="gene ID" value="DME_0000603501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230612" evidence="7">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000603501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="33178" checksum="8ABADCEDF065257A" modified="2015-12-09" version="1">MKQISLCCFLVILLNVNGWVNDEKLRIYDLIDEINANFYEFFNLSRIAAVYEILRSTDRRAIYDQILGEGLPDWRRPVYYYRFNVVNVVVNGHQDRIVIKRAQVPTFVPFHEYEVASDVKAFKAVNDIFSFGPNPETSGTGGEKKYEWSLEEMKTLIKLCNTKYRIGTPNRALQIQNGLMKVFRDMNLNDEMTNAFNLTMLKTSKKSGKNCIDAEKFDNGLSNSGIWTQIDQRNLEIALVRFPKGTEDRWDKIVEYVPNKTKQQCIDRFKELNELIRQRRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF78</accession>
    <name>A0A0N4UF78_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1016</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF78"/>
    <dbReference type="STRING" id="318479.A0A0N4UF78"/>
    <dbReference type="WBParaSite" id="DME_0000607701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000607701-mRNA-1"/>
        <property type="gene ID" value="DME_0000607701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000208">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000607701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17099" checksum="0F2D52278AF61C52" modified="2015-12-09" version="1">MTTMVGGDGGDGGGGAGGSGSDGLDIAFFVVKYSHKLLMGSCLGKKSASITTATTAAPLSCGIMHSSMVISDTVLRRLTPPNPSIVDPSVHKHSPPLFIALFDYDARTDDDLSFKKDELLYILNDMQGDWWYARSKFTKRCGYIPSNYVAREKSLDAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFA5</accession>
    <name>A0A0N4UFA5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1044</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFA5"/>
    <dbReference type="STRING" id="318479.A0A0N4UFA5"/>
    <dbReference type="WBParaSite" id="DME_0000610501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000610501-mRNA-1"/>
        <property type="gene ID" value="DME_0000610501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="166"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000610501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68559" checksum="FAE28031B1D04514" modified="2015-12-09" version="1">MSRHRNLRKLVHDDDYDYYDEEYNRYSISSDDDHVIPASCLYGKSAKDVQDDTQKNLYDCVFDRSKNSLENAAVDINGKSRKIFSVESMETSNYLSCDIPTILPIQQVQNLKISSTHSAEMHRSTSPSPSRSLVPSSSSKRLSALAQAQATIYTTPKLQKRVGDGKPLINLVIVGHVDAGKSTLMGHLLYQLGSVDERTMHKYKQESARTGKASFAFAWVMDDTQAFPLYFRLFLKFYKKEERQRGVTMDIAKTCFETDHRRIIVMDAPGHRDFIRNMISGAAQADVGVLVVDATPGKFETGYDLGGQTREHSMLLRALGINELIVVLNKMDMVSWSQTRFDEVCATLNPFLKKQAGFRLLHFVPVSGLHGINLTETVPMDHMLQWYKGSCLIQTIDDLIPPKRAEDGKFRAVINDVQKNTQSLLTLSVKIESGYVEIGEKIFIMPNADPVFVKGIVSDTQSSSDSSTYFAGEQVILNITALNNVEQDSITSGYILCRGGQECLLPGKRFLIRLVVFNIAIPIIKGTRAELYAHSLCQPCTVVRLKAALSKADGEILRQKPRCLTKNMSGIVEIETDKLVCLEPYSECRALGRITLRCADQTIAAGIVERLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFC1</accession>
    <name>A0A0N4UFC1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Condensin complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1062</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFC1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFC1"/>
    <dbReference type="WBParaSite" id="DME_0000612301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000612301-mRNA-1"/>
        <property type="gene ID" value="DME_0000612301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000612301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43536" checksum="BA41C89B7B344D58" modified="2015-12-09" version="1">MDVCDYPSGCQPITISSNNSELLKRLKILSDSLKDTDSNEDVGTPGRYRSLLNHLTQAKFLNNSNKDVQILLACCITEIFRIFAPIFYVSVLFYFQNLSVAELLLLTLDSNDDAQFILRELIKADERLRGLFISLCSKFLQNLDRIDNIVLDILFYFLIQPQKKFCLDLIVNRAHDPNEEVRMEVISMVRGLAKSKFDLISERLLMCVVQRIRDTKVKVRHAAIIVLSQLYRLVNANDEFSESERASVFIVFSIDCRMLIEKVFVLNLVPYKMEVTKRVRIMINIFRNLDLRGMRTKCSEILQTLLERCAPLQFDGETVEVLVDLAYQVIQKAANHFDDTVALRREHSVIKLIAVCFFFNKSAISLNLLFLIALTITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFT6</accession>
    <name>A0A0N4UFT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFT6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFT6"/>
    <dbReference type="WBParaSite" id="DME_0000631801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000631801-mRNA-1"/>
        <property type="gene ID" value="DME_0000631801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000631801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="72170" checksum="B937F786B92AEA42" modified="2015-12-09" version="1">MSATAARIGLRINTNKTKILSFYTEELEMPDFKYLGSTLIPNVQAKDDIKTRTTAVKNTFFRFTKFYGAIVRIFYGSVQISHDRIHLRSNTTCVNNVITVQRLRWFSHVLLRPPQELTHISLLAKPYEFHSYVVVKLQNVKSTTIAVKGNQPCWEQEFIFETNRIDNGMLVELWNKGVLWDKLLGVHYMPLTSVQYSNSHGNGKWLQIDQEVETRNGRTVGTSHPTGHSLLADVHFELPYEAQGLDAEELQAKLQALNHLIEIGDQLPHFRAPLTHSGISEDSDYTSDVSFPIHHQPNNSVHQWDSHVHPHRNSRQLDRQIQLTESVNCDYLQPFDEESDATQHASEEPIIYSSYDDEYYQQQDYGDYYPNISHYEHYQHYNENTYDNDYIGRKSWKKSFNSDWNEEQEPLSYNSRPRNMQNAISSLSRNIYSSRGMNHYDMPASESETYSQVDGRGESDNYEKEGSDETRFTPHIGEDDGDDGQRYTFNNNQQNISKYSSSRQSTIQDNLADDIFSVDNPDYIFNDKNINNNCDDVSYSKVNLEISKATVQIASNEFEDEQIHSNKNDNVVPVQTDKKDYREMWRWAYRETCKRLGIKKGFMESKCICTWIRSTLAEETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG11</accession>
    <name>A0A0N4UG11_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9514</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG11"/>
    <dbReference type="STRING" id="318479.A0A0N4UG11"/>
    <dbReference type="WBParaSite" id="DME_0000640301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000640301-mRNA-1"/>
        <property type="gene ID" value="DME_0000640301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="11">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000640301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="799" mass="91073" checksum="4B4C587B23B7A8DA" modified="2016-06-08" version="2">MASFKRCSSNYIYILINFISSIDGRHEAIHFDKISHRIEKLCYGLNPDHVDYIEVSKKVIMGLYKGVSTAELDNLAAETAADMTTIHPDYAILAARIAISNLHKNTEKIFSQVASNLYHAKNVRTGRNSPMISEEIYNIIMQNANILDSAIVHDRDFSFTYFGFKTLERSYLLRNESGIIERPQHMFMRVAVGIHKDDIDSVIETYDLMSQRWFIHATPTLFNSGTCKPQMSSCFLLTMSDDSIEGIYETLKKCALISKSAGGIGLNVHCIRATGASIAGTNGVSNGLVPMLRVFDATARYVDQGGNKRPGAFAIYLEPWHADIFEYLDLRKNFGDELERCRDLFFGLWVPDLFMNRVNSDSDWSLMCPSESPGLEDCWGEEFEKLYTQYEEEGRYRKKIKARKLWEAIVSSQIETGVPYMVYKDSCNRKSNQQNLGTIKCSNLCTEVVEYSSKDEIAVCNLASIALNRFVTNEKTFDFEKLHQVTKVITKNLNKVIDGNFYPVPEAKRSNKRHRPIGIGVQGLADAFILMRYPFISEEARKLNKQIFETIYHAALEASCELAERCGTYETYEGSPVSKGILQHDMWGVTTTDLWDWSELRMKIAKHGLRNSLLLAPMPTASTAQILGNNESVEPYTSNVYTRNVLSGSFQVFNPHLLKDLVELGLWDDEMRLEIVAKKGSIQNIHRIPQEIRELYKTVWEMSQRDIIDMASERGAFIDQSQSLNIFIAKPNYRNITSMHFYGWHRGLKTGMYYLRTRPAVDAVQFTVDKTLLKEKNISKEQFESCPLNNTDDCLMCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGA9</accession>
    <name>A0A0N4UGA9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9629</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGA9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGA9"/>
    <dbReference type="WBParaSite" id="DME_0000651801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000651801-mRNA-1"/>
        <property type="gene ID" value="DME_0000651801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000651801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41343" checksum="303386428E0F5BB6" modified="2015-12-09" version="1">MKLGVHPVRTPCGTSGSYFVRDASKKYIAIFKPKDEEPFASLNPKWPKYFQRILSFCCFGRACLIPNMGYMSELKIVPNTYLVQLASPSFFYRKQGEFKLKNGSYQCIIIFRVQLMKSYFQQRLRINRKSKNSSFQLFVDGFESANIVLAKWSHKSPLTEKESQKFHILFQKMCVLDYVIRNTDRHMDNWLIKYKQNEEIDIAAIDNGLAFPVKHPETASRLRPFPFEWANLSWALIVLLNNIFQPWDDTLKEFLLGLLTTKFVRDLCADLRTLFKYDPTANSLLIHNQLKVMRGQIWNLRCSLLNEESPAQMVKKAPILVSFRNRGYIGSITADWNEAFIVKPADYRRRQWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH59</accession>
    <name>A0A0N4UH59_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1476</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH59"/>
    <dbReference type="WBParaSite" id="DME_0000686201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000686201-mRNA-1"/>
        <property type="gene ID" value="DME_0000686201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000686201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18173" checksum="431AFB5634A48DEE" modified="2015-12-09" version="1">MEKGMAPFIVNDSVGPNNSAIVTLLLKKLNRFGECANTIASSLLENDERCLSTLSALLYLHENSVVLPDELNPRYIFVCVMYQIGFDHEITVIKQSDGCNGSLNKENLMQNMIDCFIRFRLVCERMKVANIEPFNLKFLIKAIEGVEETWEYCIMNGIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHJ9</accession>
    <name>A0A0N4UHJ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1586</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHJ9"/>
    <dbReference type="WBParaSite" id="DME_0000703401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000703401-mRNA-1"/>
        <property type="gene ID" value="DME_0000703401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849460at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493:SF5">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7808" evidence="1">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000703401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18284" checksum="FA7C872AF06EDA3C" modified="2015-12-09" version="1">MVSVPNLLGKFATNIVRRELIEIMQKLKEFRQYTCFSIRSNEPADCTLMFKENNERTTISDSGCFSERDLERHQIFTYCPLQCPGAESAYVILKKPSNNNKCAAFFSYNVVRRKNDWFFWRSGKCLYEEIQFDIGCTFPFKKLKKGKNDSFVGHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHT7</accession>
    <name>A0A0N4UHT7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9865</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHT7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHT7"/>
    <dbReference type="WBParaSite" id="DME_0000713501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000713501-mRNA-1"/>
        <property type="gene ID" value="DME_0000713501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="139"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000713501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="76542" checksum="24B07568E0B65171" modified="2016-06-08" version="2">MHRYNYLLHAAPKDVRDYLKDVKSGDEIHSLQSLRTKLNAISSQSAESMKKNVFLNYKQFINTSKEISHLEREIYELSSLLSDQKLLIENLMQMNGDDHSSVCTSSSHNTSITSNHINALMQKMDGIAGILNSLPSSERVIMYGEVTQLDSDNKRPLNPALLILLSDRLLIGHPSTGKYRFHLESSHHLNSLAAVNIKDRDGDGTDSSFKLLIFPDQRVYQAENNRLKREWLENIENAKRSLLNEGLLVRQTTIRVKRKRGNHSGSKYESSNNSAMRTIDETKVSDESAWLNELPAELDDCIAHRDMEQAVELINEWKSCPSRNSNIDAQMVIRERQIVQLLIDEVRRPGALHGGPRAVRKAINLLTSLGRASQVVELYLKRRSAVLRINARELTMSEEPLSYVRQLSQQFLGTISDVATEFTTQPEHYSLILQWCSNELSLMLSLIRRNVIEVAPTIAVLAHTWRILMSHCKSLCAIGIDLSFEVHHLLVPSLMSAIETNFDNIIESIRLRISEERWRVYNMESESNVNRFLEEMSDLGLCIDWTVSSNNRCCINITQNACHFSRVAQSLSKELSILRCSQLRDMTDSFMVQLWTEYLSHLSNSPHSSVQQHTCTFIVSQLLPSCDFVYDGSRRGILDGLLQNKFSELLKYKSSCDENGDMTTSDEEVAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHV3</accession>
    <name>A0A0N4UHV3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferrochelatase</fullName>
            <ecNumber evidence="8">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9883</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:22586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHV3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHV3"/>
    <dbReference type="WBParaSite" id="DME_0000715301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000715301-mRNA-1"/>
        <property type="gene ID" value="DME_0000715301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775002at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000715301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41673" checksum="C2F1BC209EAE5CEC" modified="2015-12-09" version="1">MEGGRQDYRLWPANMALESVLLEFAKSVIGVLLVNVGTPENYSFWTVRRYLSEFLSDRRVIEFPKILWTVILHLFILNSRPQKIGQKFRLVWNYETNESLLRMTSRLQATKTAERFRNEPVEIAWAFRYGNPTIDSTIQALKEKGCDRLILLPLFPQYSAATTASTTDEAFKSLMKQRFQMALRVIPAFYDNYLYIGAIKDSIKDKLDKINTNPEVTVIISYHSIPLQFHLKGDPYGRHCLQTTELIKKRLAVDYKVNVLTSFHSRFGPFEWLKPYTDDLIVNLARSGKKRILMVAPGFISDCFETIEELEISGAKLFKDNGGEEFVYVRCLNDSKACIDIIENVIRLHMQGFGTIAVNTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIP6</accession>
    <name>A0A0N4UIP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DRIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10071</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIP6"/>
    <dbReference type="STRING" id="318479.A0A0N4UIP6"/>
    <dbReference type="WBParaSite" id="DME_0000748601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000748601-mRNA-1"/>
        <property type="gene ID" value="DME_0000748601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="2">
        <location>
            <begin position="656"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000748601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1544" mass="176749" checksum="9D8708CB449A0A90" modified="2016-06-08" version="2">MRCSIYRRITWRSLASISHIVNKLSPSLGAQQQLIIYRLCIAISVLLRLAFEQHHRISEYNLKILKNLRRDVSRRFREIFHAFQNRKYTLDEIVSIFNYYISPYCNATSDNNDVNHNGVIAPLGILRLFFSWTQTPLLFYLLQVRISSDQTPLSIICNTALSKSTNAIARKLIVKSLLNLLNFADEKQMEVPEGLDLVNVSRIKGVNLGTCMLLAELPKLLQFIVLSLPAPGEKKRIEAKFIEILNKLGSFVSDGTIGKRFVAVLLANIETYRINEDTFLTLMSTITRLIPSLENPRIFLSSLAHLYSSVKSRNCRESLSLVTDAIALKIHDNELQTSRLLSYVSDLNAWDRRKIDEPDYDRRHNAYINLNQVWLSQERVDLALIEIFSHNHFFTLTMADIALKSAVSTNFRHLFNYMSKGPFDDEMKIEILEKHFIPLILKGLNSEKEVVRHEFIPLLVALINSFPNHHQLKYLQYLSHSDVELDFFENIINMPFEILLRFMLPLLRPYVLDFTSKTSALSDEAIRLLSYIMRLAPWKRYYTILEFYIKQISKENINRKAIIRIIVAIIDAFHFDITLDEESKKNSNAIEKDFINNNNNNNACENGETSQANDLNGAISSMSKKIVTYLIPRLRDCATGKDLLAHRKAGQGKYYSEDDAITRAPIALATVKLLLKLPQKILDENLHGIILKLCSLLMSRSINIRESARKIITNICETLGSKYLPFIIKEIKLNLKKGYQTHVMIFSIHAIIYAMEPFLNPGDLDPCLDNVIEVCNMDLFGDIADEKGVNTIIKNVPEAKSGRTYETYILLGRFISTALLGKVLAPLKEICENHPSSTAVKKIGRLLKNFAIGLNSNRAIDPPVLLIFIFQTLKDYICDMTNELGATRNEDSLGRREKNCLLLEKEPTRIGVVVKISVKSRSSLFIEFALYLLSLCVKSGKFDSEKDEDIAKLDPFINIIQQCLLFKYDKIVINSLRCYLSLLKFPLPSIRITIEAFMNCMFVLLSEYAIAGAASNKGVSLELNQLLFRIFAIVIKDAPTLVLSKERLQILLAYIETDIVDNQKQATAFSLIKSIISRKLTNQKIPSLIKYLSELCVTSEISHIRTQCRQVLSQFIGNHPQSKKSKIYTDFFSNQLEYEYEDGRISAIEMLNILFETLPQTDVDDCCIVSFMKMAIRLVNEESEICNKLVALAIKRLLSVVSDSKLNDLYLASRDWLESKNDSRRSIAMQIFVQFAESKGEVFFNSKAEIYRLIVDVLKYSFLKKCTEKNLTRILDSFNSILLNCPVSSRKYIDDGLLSSILKEMVLIGKNLDFLQIQTSVLCLSGQLFSLFNERFPLLDPSLRELIEWTCWQLKYRIQNDAMADQATKNIVSLASALTANDDVKWMCHRLSSICKYEIVRQPNKAIKRLSIFKLAAVLLLKADRVHIDVIVEIFLPLLYREMQGKSGKNIEELQGTASEVAEIFKSKLGEELFTTKLNECQKKSALKYESRKRKQKEETVTDPILGALRKQKRNKMKTSARKRKIDAAKPYRISKKRLKLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ13</accession>
    <name>A0A0N4UJ13_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Methyltransferase HEMK2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">HemK methyltransferase family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysine N-methyltransferase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methylarsonite methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein N(5)-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS1891</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16223"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer; heterodimerization with TRMT112 is required for S-adenosyl-L-methionine-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ13"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ13"/>
    <dbReference type="WBParaSite" id="DME_0000762401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000762401-mRNA-1"/>
        <property type="gene ID" value="DME_0000762401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="17">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN51918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000762401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23372" checksum="B4410CB4F11DAF7C" modified="2015-12-09" version="1">MVSLPTPAYNILDEYVGHVYEPAEDTFLLLDALEKDAEIFRALNPTIGIEVGCGSGIVSAFLLKLLGEPLFFIATDLDFITLQCTLHTALLNDVEVNVVQCDLLSAVQDRLKQNVDIILFNPPYVPTDSESTDSLVRCWSGGSTGRKTLERLLPIVPDLLTSHGLFYIVALHSNDIPYLLNINPRLRGEIVCERRCGIEHLYILKYKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJA0</accession>
    <name>A0A0N4UJA0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1942</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJA0"/>
    <dbReference type="WBParaSite" id="DME_0000772401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000772401-mRNA-1"/>
        <property type="gene ID" value="DME_0000772401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000772401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24816" checksum="C19E0C3A8F35A9A8" modified="2015-12-09" version="1">MLHRFKKLNDEDLPNEPALGDLEANGNKQNDEKNDKSRRAVTNSVCQGIPNKFTEKHQYYILDSEGLLTTYREEWDRIEKLASSKKRFDSYNHSGKFSGRSSRQSSVSYGPAQELQSFQSHRSRFPNIKPIARRPQSFRNTSSIYGSSSMNREIHSPMGKKSQQLVSVFPHRFDFFYLSEYGGDYDDNLDDDYVDNGDDDSRNFFVAIANSINNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJC0</accession>
    <name>A0A0N4UJC0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10157</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJC0"/>
    <dbReference type="STRING" id="318479.A0A0N4UJC0"/>
    <dbReference type="WBParaSite" id="DME_0000774701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000774701-mRNA-1"/>
        <property type="gene ID" value="DME_0000774701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000774701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21378" checksum="DD7CC69C59CBD1A2" modified="2015-12-09" version="1">MKELERIAPKQKGIVSQSVKEITLSLVDDGFVECEKIGTFVCYWAFPSKATVVRRVKLENLEKNINDAEKKVCEIKKQIEISKCGREENEARTALLHHFQELTKEKQNLSLRLDGLNKCGSEIIDSLKKECEKTLESINRWTDNMFDLTDNIFAIKKWCRLKFNIDMKTLDQQFGIPSDLDYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK21</accession>
    <name>A0A0N4UK21_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2168</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK21"/>
    <dbReference type="STRING" id="318479.A0A0N4UK21"/>
    <dbReference type="WBParaSite" id="DME_0000804301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000804301-mRNA-1"/>
        <property type="gene ID" value="DME_0000804301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF137">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="9">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="177"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000804301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27158" checksum="998E2F5827E2DD19" modified="2015-12-09" version="1">MELGHTSCTSYNGCISSTKPFFLQLPSDKVSIKRKILAFDDEAIRQAVSEITREERIELEEMEIFAKEFKRKRINFGLTQNDVGIALGYRFGVDFSQTTISRFEALNLSFNNMSKLKPLLEEWLAYVEAAIANGATIHYLLEATPNHSQNQFLGNLFGASNSGTSNTPGMNESRALLRKRRKRTNLDLSQRVPLALYFKLNPRPDHDKIAKLAEILELDRDVVRVWFCNRRQKIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK71</accession>
    <name>A0A0N4UK71_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2224</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK71"/>
    <dbReference type="STRING" id="318479.A0A0N4UK71"/>
    <dbReference type="WBParaSite" id="DME_0000809901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000809901-mRNA-1"/>
        <property type="gene ID" value="DME_0000809901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="241"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="546"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000809901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="71991" checksum="B317D29B2AF63858" modified="2015-12-09" version="1">MSQNVYSIGNLMIREGHRASIEGKNGSLKLQIGCSIHEKEISRHMQSRTNLCLYFKEGSFLSINYFNENELFDLYEFNWTAAEDKHYMKDIVDIESGGYWFGGPIIAQQKWPISHNSHHFAPYLPRDFLKEGEFPCSGMERYWLCSNKFAIFVPSEIPLWTEFQENRFSLQAQIQDSPFISFHQSVGAPKLIYSIFACKFTKNCSLKDFHIVVHRKLYKRSIQCPNEELIKRPIWTTWAKYKTTATQAIVEEFVDEIISYGAPISQLELDDCWETNYGDFKFDVAKYPDITQLCDKLKSNGIKVSLWIHPFLNVNCENANDNYVRKFLITNPRGDPELIEWWNGSAYIIDFTNPEGSEWFIKQLKAIQELGIHTFKFDAGEVSYLPTNFCLFSGTSPLDFVKAYVETASQFGDAIEVRVCSHCQSLPVLIRTIDRLSTWYDMGLNTLIPIALNFSIHGYNHNLPDIIGGNYYSDVMCDKELYIRWMQANLFLVVLQFSIPPWYYDDETVNHFKQLLVQRSIVMPHLIEACRKNCKNGEPIIWCILLNPLWWFSETVDALKCSDQFLINNRIMVTPVLEKGATSRSVYIPKGAWKYHANNIIYEGISNIHIEVKAKYYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKD2</accession>
    <name>A0A0N4UKD2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2245</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000051">
        <property type="protein sequence ID" value="VDN52272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKD2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKD2"/>
    <dbReference type="WBParaSite" id="DME_0000816901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000816901-mRNA-1"/>
        <property type="gene ID" value="DME_0000816901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF112">
        <property type="entry name" value="FEM-3 MRNA-BINDING FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000816901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29363" checksum="BA8FFBDF23D4EA32" modified="2015-12-09" version="1">MDFATASQKKSIASLLSKRIVDLSFNKYSCYVVEKAIICLGHSYQLQMVKNIKGAECKLSINRNGNHVIQHIFEHVPLYAYKSVIESLISSSEIFYKIVTDKYGCRVIEHAIQNLEFQVMNSNSQQARDLLNNILPISQTKHASYLVQKAFIYAPSELLHAMMNEIFDYCNKQTEHNKCAIDVMLYDKFGKHVIQTMFDIAIKVKFEGIKGESIWFDRIAEHILRHRKELLRHSSGRKIVEKLYEVSNFFSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKN9</accession>
    <name>A0A0N4UKN9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10331</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKN9"/>
    <dbReference type="STRING" id="318479.A0A0N4UKN9"/>
    <dbReference type="WBParaSite" id="DME_0000831401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000831401-mRNA-1"/>
        <property type="gene ID" value="DME_0000831401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918422at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000831401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7611" checksum="F4619DE31F308C7B" modified="2015-12-09" version="1">MSGRGKGGKAKTSGKAKSRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVLEYLAAEVLELAGNAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL03</accession>
    <name>A0A0N4UL03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NOT2_3_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2425</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000060">
        <property type="protein sequence ID" value="VDN52452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL03"/>
    <dbReference type="STRING" id="318479.A0A0N4UL03"/>
    <dbReference type="WBParaSite" id="DME_0000845001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000845001-mRNA-1"/>
        <property type="gene ID" value="DME_0000845001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="166"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000845001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30541" checksum="24189CB5D85E852C" modified="2015-12-09" version="1">MRAGEGSSGNSEFHIQNEDFPALPGATHLESTHSQLKSGNSDNVVQDARYLDRSNIEKLGIITSPDGLVKNIPPTMLADQFGMAGLLTFLRAIELDPQIVGLALGHDLTNLGLNLNAPERNVYATFAGPWSDVSCRVQDMDTKVTFERQFDLAVLSFLFFNQLLSLQVPDEYMTNLSIRDKLPGIKLNKLSEDVLFYLFYNCPGEIYQMAAANELYGRDWRFHKTQCVWLTRSQYGVVKEQTSVFERGSYNVFDPTQWRKVRIFLNQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULC0</accession>
    <name>A0A0N4ULC0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10435</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001217">
        <property type="protein sequence ID" value="VDN60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULC0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULC0"/>
    <dbReference type="WBParaSite" id="DME_0000858801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000858801-mRNA-1"/>
        <property type="gene ID" value="DME_0000858801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000858801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7828" checksum="CE5FD37B9B49E4AB" modified="2015-12-09" version="1">MIIPIRCFTCGKVIGNKWDSYLGLLQAEYTEGDALDALNLRRYCCRRMLLSHVDLIEKLLNYHPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULH8</accession>
    <name>A0A0N4ULH8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2568</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULH8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULH8"/>
    <dbReference type="WBParaSite" id="DME_0000865301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000865301-mRNA-1"/>
        <property type="gene ID" value="DME_0000865301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063208at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF4">
        <property type="entry name" value="GEO03726P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000865301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9114" checksum="4AEEEB114808A5C6" modified="2015-12-09" version="1">MTSPRNQPKKRGRARTKEESEPIGWLCTVCTLINRHEMFKCEACGTRKGTSTRKPRLNQSVVQHHTVVHNFVLQQSQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULK3</accession>
    <name>A0A0N4ULK3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS2596</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULK3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULK3"/>
    <dbReference type="WBParaSite" id="DME_0000868101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000868101-mRNA-1"/>
        <property type="gene ID" value="DME_0000868101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="136"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN52623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000868101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="587" mass="68421" checksum="89D9767514128F2E" modified="2016-06-08" version="2">MSLKRFATLALHFTEVLLYKFGKYSASSRISLLPIVKANLRKNVGLTEFTQNKYTLTRLFRSILRGLNSRMFIRPFSTVDHNKVRFSNGRINRHYFIVIKRKPYTVFDKIKHLFSTHERFNRTLLGADLPDRLDGYDIGSNIACGCNAAIYELRVKEPILNIRRSNAPLENHEFPSTSNFSRDYSVGARLKAYPLALKIMFNYDFDLPEHYLWLDMCNELIPLDDAKHLLRDRFINLRTLPHCHPNIVKMYKAFIDRMPIFEEAQNLYPEALPTATFHGNTLLEPRTMFIIMKRYRMTLREYILTRKRNYWTGRVLFGQLLEAIVFLFDNQISHRDMKSDNILLDFDCDSDIPHLVLSDFGCALATGSFLVNYTNDEVNLGGNLSLRAPEVRRAVPGIGHFVNFSMADLWAAGTIGYEIFTRMNPFYKQMKSYDYMEFELPQLPRRIHYAVKMIIREMLRIDPQKRPKPHVAANLICLSLFRFGEDFKQYLIGSGIDFLFSTEGISKLGHLEQGTGDKIRLFERKIMENLNDVMLLYASETILAKNLEGVAISQAEIQLRSTFLSRLDYEDVWSAIAYFYVDEEKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULY3</accession>
    <name>A0A0N4ULY3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10486</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001220">
        <property type="protein sequence ID" value="VDN60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULY3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULY3"/>
    <dbReference type="WBParaSite" id="DME_0000883001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000883001-mRNA-1"/>
        <property type="gene ID" value="DME_0000883001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000883001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="19412" checksum="FC10602D26C22AA6" modified="2015-12-09" version="1">MRDKYRLVKRTQLKRSDVDRIGSDAEITYDVEIFDDDDFYQQLLKDIIEKKTAQIDDPVYMSRRWLEIENLRQKRSKKKKVDTKASKGRRIRYLVIPQLVNYYPSMPESVSWSHEMRNQLMKSLFVSDSQIYLCIHEKLPVNVTVIVVYNFTREFFDIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM99</accession>
    <name>A0A0N4UM99_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2792</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM99"/>
    <dbReference type="STRING" id="318479.A0A0N4UM99"/>
    <dbReference type="WBParaSite" id="DME_0000896301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000896301-mRNA-1"/>
        <property type="gene ID" value="DME_0000896301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF89">
        <property type="entry name" value="POU DOMAIN PROTEIN 2, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000896301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35132" checksum="CEF92496769A0DFB" modified="2015-12-09" version="1">MLSSAFSAPEEATYTQVIKPTCEAFQEIGERWPSQQPIQYPPQASASFQLLFPSQTDWSSYHHHHHHAHIQQLQQSTVMAPPPPPQSQVEMKQEPERPDIIQRLSAAPSSWPYTFSQEDLALCSNQLPDDSDSTCSEDLEAFAKAFKQRRIKLGYTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLYKWLEEADSTSSSPNSAFEKMTGQGGRKRKKRTSIEVQVKNRLEYHFQKNPKPNAQEIAQVALELQLEKEVVRVWFCNRRQKEKRMTPQYGQELLVHSNPYSQDTFVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMI9</accession>
    <name>A0A0N4UMI9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2841</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000084">
        <property type="protein sequence ID" value="VDN52868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMI9"/>
    <dbReference type="WBParaSite" id="DME_0000906701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000906701-mRNA-1"/>
        <property type="gene ID" value="DME_0000906701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000906701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24467" checksum="99A0A6E4F78E1120" modified="2015-12-09" version="1">MKFVPVNHRIFAILPLSRNPWRQVCVQQCRCAGNEYLERCINITPQAKETSLTKISSTKVWKKCPKDFCALGEKVYDHSCKLTNRKCGENMKFVTINRKTDDFYLFSSFISHHRTCIQQCTCASENYVKKDGRCIQKLAERAITEAIAHSYGDEWFDYSCELIGSKCGQNMIFAKIDPHLSYFHALPRFFSSSFCVVQCKCVEFYEEENGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMK8</accession>
    <name>A0A0N4UMK8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10594</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001227">
        <property type="protein sequence ID" value="VDN60621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMK8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMK8"/>
    <dbReference type="WBParaSite" id="DME_0000909001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000909001-mRNA-1"/>
        <property type="gene ID" value="DME_0000909001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF8">
        <property type="entry name" value="FORMIN-HOMOLOGY AND ZINC FINGER DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="308"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000909001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="675" mass="74771" checksum="D63E972FF0BFCED2" modified="2016-06-08" version="2">MLVNGTLTAATTHTTAMIPPNAINATNSTTTTTTTSGDLAAFLAASSNCISETVFGNQINLNDAATLFSLLAQQQQQALLQRLQAAQRENSRQKNAIQEKKRSYPCTFQYCVLCQKNVHSSKLPCHIRQCHVAKPMFRCPACDFTSTYSKNNVKSHMVSLHGLGGDPISFMEQYAGQVEEYMKKCFPNVRGRGRPIHTNGDRQSPNSPVSPQNGQTSASRRGSINNSPPNASNNQNIPISLNDQLWALNQPHYIKNENNIASDSRPIFDAKSSPTETQNVSATADVKTGKAIKLEPIENGNNKLLDVALPSSEGEASSATSEGDNLISEGDGDEVVANAANTIQDITNHRKSSIFIRLNLASFAPFFGESIFLNEEQLKKVAEVRKQINLRNFEIMFAVDRMDLDVLPVESVDLIQSIAPSAIDIHRFKTYEMSNSVSCLNESEQFILQLAKIERVAENLSAMSHMGHFIKEANNLLQQLDELRQAAKTLIESDVLFALLHLFLTCGNIICGDFNAQTIKGYRTSCILQMCSFKFPTSETTLLMVVVKEIISHFPELKKLDDLISAVEKGAKIKFSALTTAICDFYSNHLFTMAELDRIKKTSSISAFISTSEPLLIELIDSFRQTKEKLISMLKYFGEIVEINESALEPELFFQTILAFCNKLQTAFDEFAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMW9</accession>
    <name>A0A0N4UMW9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2959</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000092">
        <property type="protein sequence ID" value="VDN52986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMW9"/>
    <dbReference type="STRING" id="318479.A0A0N4UMW9"/>
    <dbReference type="WBParaSite" id="DME_0000922201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000922201-mRNA-1"/>
        <property type="gene ID" value="DME_0000922201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26518at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="409"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000922201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="702" mass="80082" checksum="37A35D2723B8903B" modified="2015-12-09" version="1">MICNLNAKLETLIEKYRKIDTHHQSKFRRKRTIDEKFLGKNFLKRPKYYFKEIENFKFDLFKLNEANSLAVIDLLNRIIHKKNGFQIVIDCLSCWQDIIGTNYCLETIANEFIHSNDAEVLHSCLTLLNRLLQYAPNAVARIRIDHELKVGIIIFKIKDVILLFHMTSVFYFDVIKEINCFAYYPSIALAYQLNVDARIDYIRASKLSGLFGKFSRSIDDQIDLWITQHSRNPRSSYEENEDIRSDSGESDEGCSMTSTTATSESLSGDNRSQIDLILLQLINILKGETNAVCLTTIEAILSAICSQTDCDKIMNILKNEAENLQNASSKVVHSIKPVISSTVLPTTVASPPPPPPPPPPQTVLLPTALANGCLQPSKGIQAPPAPPPPLNLRRSDNEKKMEIPKALRLKSLPREGAKLKQIQWTKIPAEKILDFDSNKVENVWMSLAKLPENEFYLNFDELESMFSCGERNFIDTTTTLERKQSRKNESISLLCHKRSFNVSIFLRQFKEEYSHYVKFMRNLKPHLWPIYKNFIGIALKFLNLTGPEQVIENIKEGKGELIGYERLHTLQTILPDNEEMEILRGFSGDITQLGLAEQFFLNLTTVNDYSLKLNCLILKEELKNIFNIVQPQIDIILTALSEIKDSESLRKIFCILLQVGNFLNANGNCGNAIGFRLNSLWKIIDMKAAKQSLTLIHFIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNQ4</accession>
    <name>A0A0N4UNQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3217</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000114">
        <property type="protein sequence ID" value="VDN53244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNQ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UNQ4"/>
    <dbReference type="WBParaSite" id="DME_0000955001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000955001-mRNA-1"/>
        <property type="gene ID" value="DME_0000955001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF15">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720760" evidence="1">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000955001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16633" checksum="A64DE030FEC3B0B0" modified="2015-12-09" version="1">MSPVRNLFHGSLFFVIVTYAQRESANEKLKRCCKAQESKFTNNQTAINVCLRAYCDFDSISQTNILVYLKHCDNRVVGTMFSCASSNVDHTKCCVDKGVSKKCLEYCSAQDGAPNNYVDYIFCVEEFNSIRDCFADFLEKHEPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNV3</accession>
    <name>A0A0N4UNV3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10696</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001237">
        <property type="protein sequence ID" value="VDN60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNV3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNV3"/>
    <dbReference type="WBParaSite" id="DME_0000961101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000961101-mRNA-1"/>
        <property type="gene ID" value="DME_0000961101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859947at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000961101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27392" checksum="F007C5931DA452BC" modified="2015-12-09" version="1">FQYKFFFHYKVSEKIEAPLIAETNCESSRFIASGREDIDVRMLGYGRPFAVQLINPRLTKNFHGSLLNDTLKRLTVEINKDKDIRLPCNLQKINDKELNILKVGQDEKRKCYTAYCYYTQKLCVDLMENLQCKTPFQIIQKTPVRVLRRRPLLDRIRTIYNLHLLMLDDFHFLMRIETQAGTYVKEFVHGDFGRTRPSLAELLKVESGEMDILQLDVEKVDMEWPPRINLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNV6</accession>
    <name>A0A0N4UNV6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha,alpha-trehalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10702</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001237">
        <property type="protein sequence ID" value="VDN60729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNV6"/>
    <dbReference type="WBParaSite" id="DME_0000961701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000961701-mRNA-1"/>
        <property type="gene ID" value="DME_0000961701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874379at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000961701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="5049" checksum="E52DE1D493D9FD32" modified="2015-12-09" version="1">MKYFQKQPIISTFQDGFGWTNGVVLDLLVTYQNRLKLPESMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQT0</accession>
    <name>A0A0N4UQT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3421 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000203">
        <property type="protein sequence ID" value="VDN53882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQT0"/>
    <dbReference type="WBParaSite" id="DME_0001038501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001038501-mRNA-1"/>
        <property type="gene ID" value="DME_0001038501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5801705at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001038501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12010" checksum="1D2E991064013F04" modified="2015-12-09" version="1">MASNNLDITLVASEASLTSNVVGCKKGSNYFNEGQIWTEKHVRYQCVSDGVLKVLGCVDDGGFIELGKDVLVNGVVHRCYRIGSVTYYHRFRCDAQTLAQCTKNMRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQY3</accession>
    <name>A0A0N4UQY3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Submaxillary mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3903</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000213">
        <property type="protein sequence ID" value="VDN53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQY3"/>
    <dbReference type="WBParaSite" id="DME_0001044701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001044701-mRNA-1"/>
        <property type="gene ID" value="DME_0001044701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001044701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45768" checksum="97C7B6C85653CCE7" modified="2015-12-09" version="1">MIIPTALLCYAGQSCAQIYDRLCMQTGRKCGHNMAYRTVDRLEYTDDVSPELICIQECACISEQYEKRDGQCIEKNNNSTRNKAELPIEVPTLKVCSGRICRLDEIITDTLCLLTDQKCGPNMVFKTTVGPLRMKVGISSYQMCIQQCTCDSNEYTKMGGQCIKKSSAPMRNETEFGGEILPKHCTGRVCALDEEIFNVPCSLTGEICGTNMIFNNIGKFLKKNGTEVCIQKCTCMSEEYVKANGQCILPAEGNEIASPSLIQQSAEGNESVIPISTQQSTEGNESLTPTSTQQSAEGNESLSETPANCVGLSCGKIRDPFCMRTGWKCGDNMLYTTVERLVYIDDSPEICIQQCKCVSEEYIEKDGQCIKQERKVTRKATTRDRHWYAKYRKNMSSYLVPPSPDKKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQY7</accession>
    <name>A0A0N4UQY7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001272">
        <property type="protein sequence ID" value="VDN60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQY7"/>
    <dbReference type="WBParaSite" id="DME_0001045301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001045301-mRNA-1"/>
        <property type="gene ID" value="DME_0001045301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001045301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9188" checksum="6BF6375118A05709" modified="2015-12-09" version="1">MSGNCAYGEEITDYGCHKTNQDCGINMKFQKLYKVLLLEYSYPVSRCMQRCVCDKNAYIGNGRKCIKKEFLGQQKATMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR11</accession>
    <name>A0A0N4UR11_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3927</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000220">
        <property type="protein sequence ID" value="VDN53954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR11"/>
    <dbReference type="STRING" id="318479.A0A0N4UR11"/>
    <dbReference type="WBParaSite" id="DME_0001047801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047801-mRNA-1"/>
        <property type="gene ID" value="DME_0001047801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6144703at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="41308" checksum="978E91289B1A8F03" modified="2015-12-09" version="1">MEQQSANYLRAPPVEISNRSKRASLRNSFRDLHVPKIWTDIRDKSASELNLVLEVVRGSPSLSCDRLSHPNKQENFVKNMANKKRGHQKVCWRYYKPQYLNKQLHIVQEEKAMQSAPTAPIDVSKFVAYVTERRKKRILFKGEYLMILRSIDPVKCRSEIGIAMNKRNQYPDILPYDFNRVILKKLPNDEDSHYINASYVNSWLREKAYVITQAVKTKAAIAEFWRMIWELGSSCIIMLTKVFDFMRVMCLQYWPVNNCKYGEINIETIETKSYSHFVIRTLRLTKMDPNIGTQVRLVRHFHFTEWELDSFPYISALIELRRRMRQFTDKNRSDAPIVVHCRPVTYFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3F1</accession>
    <name>A0A158Q3F1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6623</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3F1"/>
    <dbReference type="STRING" id="318479.A0A158Q3F1"/>
    <dbReference type="WBParaSite" id="DME_0000226301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000226301-mRNA-1"/>
        <property type="gene ID" value="DME_0000226301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5838894at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="14">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="156"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="779"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000226301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="916" mass="105343" checksum="D747306A4E00E592" modified="2016-06-08" version="1">MSIKLMKQRWLSEVGDARNDLNDVIDMEIDDEGESNVEGDKKVEDERQQEEKVKIMETVVKQANINENKTSEKSDNENIQPAWFEKIEENVILCDENLIKEAKVVRCFCEPTENEITEGRGCGPGCINRDLYTECGSRCPSGPMCSNRRFRNKEYANVEVFHAGIKGWGLRAAEPIEPGRFIIEYVGEVIDSEEMQRRGRRYGKDPKHIHHYLMALKNGAVIDATQRGNISRFINHSCDPNCESQKWAVDRQLRVGFFSIRSIKVGEEIVFDYQLERYGRKAQRCFCGASNCRGLIGEDTDSDDDEKEDNDYQESDNDGKIPEQNGLINVRITPEEAGRKTRKKKKRMRNMDLVRFLFLVTAIMAALKRGAPTNRVEVQALVQLMIQVEQAPQRCKLIKCMQFAHPDVLRIFMQNCGLRLLYVFLATDYPVDDRQYVYELMVASLDLLQVMPIINRNQVNDSHLAATVQKLANKIGPIDEIVEERVRHMINVISGDSPSTSESSLPGTSCCIDETLENLHFSLVCKARNLMLRWNRLREEFRIPRREKSGTPDDANERIDKEEKLRRRSVLQESGKKVENSWKTRRIVLPQRERNNDNRFIRKRVWYLFNIEGFSPTSSGAEAVPSRRSRFDVVSKDADMLSSTFEGYTDENEEMYVIPPPPMLLPESLFAAGLPTLPYYPPFAPYDWNAVYGVYDSAYQHFDYQQQQYNVHQEMNLKSILEAPSPPANIPKVSTESCDSKKNLLVIEPIDLDKVTDEQIEMMEKHLALIKEKRAERKKKELENATFTAPPPPPPSTPPKKSKESSWTLPDEGDDAADTTSDRNDSRAIFKATIARHVANILDPIRKAKFSSSDDYKYVLRKLTHTILEKELKRIGEGELKVTDSVKEKARRYVSDYITRLGDGQYCRKNKQHNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3V2</accession>
    <name>A0A158Q3V2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PRP18 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7406</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3V2"/>
    <dbReference type="STRING" id="318479.A0A158Q3V2"/>
    <dbReference type="WBParaSite" id="DME_0000324701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000324701-mRNA-1"/>
        <property type="gene ID" value="DME_0000324701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="11">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000324701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="612" mass="71753" checksum="46325348E54AF9C8" modified="2016-06-08" version="1">MEIITAEIERKRKQIKDIEHVEPSGMKYIKRSDLSAKQEEEYWKRYLSNFFQQSLKKFGYNFKSIDGTISKTNSNQKENEFDVDDMPWSEIVKRLRGRSQPILLFGETRKDSRLRLRKLEIEQPDMKEGWKNDFQSAMREVDHELIEEVIKGQQDNAGRHDVDMPNSAGDTSWERIEANARLLGEGENPNRDCDIIREFFSYILTRWGKALNARDEATKRHGCASDFLSFLLIHKLKSAEGKLAATMHKQTMEHLRPLMSNLEKHNVNADIREHLIKICRLLIIDRDYIRANNAYMEMAIGNAPWPVGVTRSGLHQRPGSAKAYVSNIAHVLNDETQRKYIQAIINEFQAFKRLMTRCQKFFQLLKFFRNQIEKFFEEKMENDEDIDEVHLCAPYNYIRKMPGKGIRNQMTKAFNLWLNIDEQIMNNILSIIELLHNASLMVDDIEDGTVLRRGLPVTHSIYGVPRTINTANYMYFVALSKCLKLNNFEAVDLFTHYIQELHRGQGKEIYWRDTPHCPTEKEYEKMVLQKTGSLFHLPIRLMQLFSGRSYDFTSLIHHISLYFQIRDDYINLCSKEYEAQKGFAEDLTEGKFSFLIIAAVSRDNRDDEILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q470</accession>
    <name>A0A158Q470_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS8021</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q470"/>
    <dbReference type="STRING" id="318479.A0A158Q470"/>
    <dbReference type="WBParaSite" id="DME_0000413801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000413801-mRNA-1"/>
        <property type="gene ID" value="DME_0000413801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="189"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="308"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN58048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000413801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="610" mass="70998" checksum="90C959FBA5CBA934" modified="2016-06-08" version="1">MGGKLKRRGEKEEGVSTVTENEIQINTVNLAKVEAKNRIETSEQRLLQFLMKNYEKSVRPVRNPSHTVTVKLGMTMTNIFEMDEKNQVLTINVWLDQEWKDELLQWDPSDFDGIESIRIPSHLIWLPDIVLYNKFVLMLNLLQFFSELFSIILILSNRLNDFILSYRSNIICHFLPNRTICIWYFSADDYSIGHVESRAMLFYDGSVFWPPPAQLRSTCKVDVTYFPFDRQHCALKFGSWSYHGIQLDIINRSENVDLSNYVISGEFDLVNVNQKRKVVKYNCCPELYPDVTFFIHIQRKTLYYLYNIILPCLMMSILTLLVFLLPPDSGEKIALGITVLLAFSVFVLTIAEKIPETSDSVPLIGIYLSMVMGMTSISVVMTVMVLNFHHRGPYCRTVPPWIRFSVLGKLRKILKMQLKHNANNNNDILSADENPTDFDLKCAIGKEFHFLNFFSFSLSTIEKLNLQRHRQDFIFLYQVQSHQIPEIMFILLGLSVTGYDGLDNQPFISESALLRRNVGEKHSENNCTVTSMPDEHIYRALRMLLKKRYLEECSQRVINEWQQVAQIIDRFLFWVFLICTIVISIILLIIVPVVHRLSNLDKFDDERYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4U3</accession>
    <name>A0A158Q4U3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Swiss cheese</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9319</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4U3"/>
    <dbReference type="STRING" id="318479.A0A158Q4U3"/>
    <dbReference type="WBParaSite" id="DME_0000572601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000572601-mRNA-1"/>
        <property type="gene ID" value="DME_0000572601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="242"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="389"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="13">
        <location>
            <begin position="728"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="9">
        <location>
            <begin position="732"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="759"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="9">
        <location>
            <begin position="881"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000572601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129321" checksum="1A20D851DBC2154B" modified="2016-06-08" version="1">MHLLLLFSFIIRGRGRFKRQLSELNSTALPKPPVEFFEPLELPGIPQNLKPEMFYILQHFKMLELPSGWNINPTEIEIKSYLQQEIIVQSDDSDDSIIVVLEGSIGVYITHGETREHLVRRISVGESFFSFLSLLEILIVSCSFLEFPFVLRYRIHSFRDSFLKNPADWVRPIQIVITRLLHVTLTTLYQYLGLCSELMKKSQMLLILVHLTNFSTFLVVCDLTSFLFPDSNEYMIRAQRFFVEALNLDENSEAVSFLQDRIQIKTIPENHLIQQQGANSDEMIVVVDGILKVFQVYHIHSCSVILNDEDCTDDQWHHFIYPRELFGALHLLTNEASFYSLQSHTCATIAYISKKDFFELVDLNPEVILPVAYSVIRRLSTFVRNVDFAIDWVLLDSGQAVYRSGDIADSVFVVLSGRLRSVEKQQVVEEFGRGDMIGMIEVLQRVPRGTTVLATRFSQLARVSEGLLNYIKLKYPQVGFTLIHVLGHYYTSSVKRPLVFSTTFRDRFLSSAGDPKSHIKNLRTIAVTAASKEVPLVAFTCELFHALSAHVRVLRLSSQKVAEHLDIGVLQKQADFRLMHWLNMQEDIYPLIIYECDEKPTNWTKKCLRQADVILFVAKGDQEPDKKSFMDEYLRMNQDGIRTNKELILLWDEDTDTPRGTMEWLKGNWFSGHHHVRGGKRMFQWAEQKKVEQEILDFYEKNVYISKVNNQSDFCRLGRILTGNAIGVVLGGGGARGAAHVGILRALNEFGIPVDMVAGTSMGAFIGALRAESVESEEIKIRTSDWFGSMCSFWLRLWDLTYAHSAMFTGTGFNQTIQDAFSDKQIEDLWIPYFCVTTDISSSEARVHRSGPLWAYCRASMSLAGYLPPLCDPVDGHLLLDGGYVNNLPADVMKSIGAKFVIAVDVGSAVENDLFNYGDSLNGFWVLLKKLNPFGKSVKILNMEEIQSRLAYVSCVQQLEQVKNALYCYYVRPPIEGFKTLDFSKFLEIENIGYEHGMAVFPDLIRKNELIRKFRGTMKLVVFDHALSSSFTNLAAQASKVPKARNKNNADSSEEDPLQSSEESNNGGVNIDNAFDKSAIVDGYASEPSAHSNSYFLNISSGEESVDENLLIHQNRRRISFVDEKFDKSPANDNHKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4X3</accession>
    <name>A0A158Q4X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RGM domain family member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS882</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4X3"/>
    <dbReference type="STRING" id="318479.A0A158Q4X3"/>
    <dbReference type="WBParaSite" id="DME_0000594301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000594301-mRNA-1"/>
        <property type="gene ID" value="DME_0000594301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF6">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE B HOMOLOG DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000594301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43168" checksum="897FEBF301173901" modified="2016-06-08" version="1">MYSQWLDEGGISIGTNAPYCQVITDYIYCLQGISRTCRGILKFHTLQTLLDRQRTEFSCRSFPESMKPSESFDRKCYTVIANATNIATRYCSLFGSRHLRTFDGRFQTCANEGAYPVVDNQYLLIQITHSNLASAENAITKITVIIRPTKKCLSRKRYETGVEDVELSSSFVDGTTYAGEENQKIVEIKQHNNSYVEILLRHTATSIYIRRHGPFLSIAVRMPESLVEAKVGEEEERMCVSGCSRGETIKIEEALANPLSFSKCYGVKTKTPIKIAIDQCSRAGTMDAFFDACVFDLMMTGNKMFVEMAASAKQNIMSMYEPYNKHYSTGRMNLTIYDSKAGYQWTQCVMAEAHSSVNLSSPSFSIIMTLIVWIMFHFMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q560</accession>
    <name>A0A158Q560_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9663</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q560"/>
    <dbReference type="STRING" id="318479.A0A158Q560"/>
    <dbReference type="WBParaSite" id="DME_0000655201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000655201-mRNA-1"/>
        <property type="gene ID" value="DME_0000655201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000655201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34478" checksum="3617E38CB01DBC97" modified="2016-06-08" version="1">MERAPPWCSRQRLRTVRLPRKSCERAVVSAHRRSVLAFFFHFSMDVTTTHPEKLRKYYALLGDRALELHESEKTQKKKRHPRHIIDMSTCFNVHRHYEGKLKYCIAVMTPDETFFLKDETDIATDEWFDCLISVLIPSRALHLGRPVLASEFFEYAWDVTIVSHPKLKKPMPNPDKIPNMCKKEPSWMGFQRLCFYPHTIILCKKGIEPAGLKDLHPSCIPPFRQNDFTELSRKYIATFGCQEKYFMMRMGRASPSGTAEIWALCENEEVASEIHDCLNKIIERESEKKKKIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q587</accession>
    <name>A0A158Q587_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1415</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q587"/>
    <dbReference type="STRING" id="318479.A0A158Q587"/>
    <dbReference type="WBParaSite" id="DME_0000680101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000680101-mRNA-1"/>
        <property type="gene ID" value="DME_0000680101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000680101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39274" checksum="4EA230C811594EEE" modified="2016-06-08" version="1">MGNILFRRKKIITEELQKLHERHQLLEEQIRNNISSKHSIQCFSTLVLLACMTVSIGISLFRARDSAQCILYSLISFFAGMVVLYSTRFITEKFFNWCIQKKRDACYEIVKKKHEILERVKETETFKVAKEILDEFGESAYHPPASSNMSKINPANEVTSVQHISSSDSAPYRFNSSLNQLRKRTNAQSIDSKTEVVNPMKMPPRPFVRQSRSVIEKFVDFVFGDGPNNRYALICSHCYEHNGMSREEEFDYMSYRCWVCGEFNPARRQRRSIFVPHIERKNSNQSRDSLGKSRFNVADVIDTNCAKDSLVEKLENDIPTSGEEKMLNSHGGDSHEEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5I0</accession>
    <name>A0A158Q5I0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1767</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5I0"/>
    <dbReference type="STRING" id="318479.A0A158Q5I0"/>
    <dbReference type="WBParaSite" id="DME_0000747401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000747401-mRNA-1"/>
        <property type="gene ID" value="DME_0000747401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000747401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="653" mass="74067" checksum="DE31E7E070D383CE" modified="2016-06-08" version="1">MSPCGYDLRYDLSEVRPLVIYVKNELPVRLVEIQLAKAIRKNSICIIAGETGSGKSTQIPQICIENDLAGSGNIVITQPRRIAAITIAECVAQEMNCSPGELVGYKIRFENVTNEETRIIYGTDGIFLREAFYDSLLSQYSIIIVDEAHERSIHTDILLFILKLIHNQRKNTKNPLKLIIMSATLDTDLLSDYFDQAPVFLIEGRRYPIELFYACSLKESRDDYVFNCLATLMQVHQSEPTDSGVLVFLTGQEEIEAACKQVYEISDRLDKKILVLPLYANLSPSAQMRDVRKVVFSTNIAETSVTIPGIKIVIDSGKVKIRTFLPDRRIDVLRVEDVCRASATQRAGRAGREAPGKCYRLYSEKDFQAFEATAIPEILRSNLSSVLLELLRIGLRKIRSLSLPSSPSIDAIKSAQYQLRMLDALQPVDHKGRIFLTDLGNKLSAFPIDPPLARVLIAASQQNCLEEALTIVSFMAAESIYITSSSDRDASNNSRKKYEAIEGDHITLLNIYRAYRFEKYDKKEWCITNFVNERVMNIVIKIRRQLREICQKNEMNFVSCGTDRTKLRKALCTGLFMNSCEYDRSSDSYRLVLSPETIVKIHPSSCLAHSRPTTFIYSDLVKTCELYARDITVVDSEWIKEIIEKKKHLLVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5J4</accession>
    <name>A0A158Q5J4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty-acid and retinol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5J4"/>
    <dbReference type="WBParaSite" id="DME_0000754801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000754801-mRNA-1"/>
        <property type="gene ID" value="DME_0000754801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788395at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044466" evidence="1">
        <location>
            <begin position="25"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000754801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51913" checksum="AB4B53A40D73CBFA" modified="2016-06-08" version="1">MSTFPVLAIHSLFLFFAIFASDLSLDVGSGAASQLLRKATNLALNSPRPLQFTLNTHQQPFLSSLALIETTNRISYSNLTIKFSPEIIHLLANDVKLYSISNVSPNIWPVSFGDEVVDFTVQIRKLKISAKIDENSVSMNSCYFKETSVNASSHNYWIFATILSILSEPIQSNLEYLLCPVIADFMVSNQSATIKFVVEKHIRIIAQLEWNRLSMFDGLKSPVFNITDFDIEFDGEDRLTAWIDDAGINDMLKQVDWSFHWMEQLIAVTSPVIPLSSREFLSTLCVSCYFLLNVWAKGSPIITATNASIILEKRDRINLKVVNPDKNVTSVFISMQLSINAELRPVIDGGILRTSVQLLDTNVVMENGAFPPSWSLFVQDLVRGMIIDMMWPELKKQIEELTYSEGIELPLSCGIDPHHTEILIGESQLGFSASLNLQRLQIQQCINDIKKALPNTSKLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5U7</accession>
    <name>A0A158Q5U7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2348</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000056">
        <property type="protein sequence ID" value="VDN52375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5U7"/>
    <dbReference type="STRING" id="318479.A0A158Q5U7"/>
    <dbReference type="WBParaSite" id="DME_0000834201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000834201-mRNA-1"/>
        <property type="gene ID" value="DME_0000834201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="937"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000834201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1481" mass="166834" checksum="B5F6A686B97A3A96" modified="2016-06-08" version="1">MAAGQLSLGKYDGMPSLSNQKLHGLQATEDFAVHHPIILNNVDMHNKNKFPKEYVENTAKLEQIPLPIVSEIRPNELVNKMMSQTSTNGSLKNIMHLINGEHERQIVPAISSKAYQSGFFDERFFMTNISYRVPEITKAEYEADKTMERKPIFNQYDGTREEIIIDKNQMPSISIAQPEEVLEVLEEREFKISGNNDAKRSQHVHSNDSFFEGRNELTTDHRIAGTDGALKDEDLSKKDEIEQKLAESSLHLNAMSQSIADADALQMLLREFQPVNYELEANGEILWSNKHIFEDPIVIMNDSKSGTEILSLNAKSNETLEFSCNLPEKVFCATDFMSDGSSRLRVVLSSVKNLTSFDLPISVISKPKNNDSYKIDKIIMIHFVVGKKEFSLSEVENDKLFANENELRIVLNTSTTPHETDPKFIAIPAIKNVFKSNLPSFSNPYIDFTKITNISTLITKNEEAGDNITATAAASNQSQYLATKIFDTTRKDLFKVNTVALFDNTISNATNKSQLDSFEINTAKNDSTFEHFTTTDKYINVDAGLQSSESTFLPHFEHNSYDCYIEKGSNKKSLVLATINFIGYSGNEPPAFSITDDNNDWFEIGEISYDEANQRNFVAKTVINVEILAFIVDGQKTNSLTTSRDDLNSSAVGHERSTKVTPLMDSSTSIINAMEIGDVHKPQFDTEYKGIHLDNSENSFLELQNTIDSTKISYVEQMEDANKPQSHKVSSDFIPKLGNMRDSSIDLAKIQQFPKTIVSFSTDTDNTDFKRIKDITSDNTAFSKNYGVNTIGFIENKKEKIMQNDFNEKFLTKETTNSKIDLSNLPEKFSDQQRRKIYETELDMKFEMKDAKTLTIPENLKCGDIVPNFKIMITAIEMDPFDVIIVNVNSTIFDIVPQRMQPGKTVTAFMRSRSYIFISKTLTVMKKDSSDNPPRFTNNEYVFHVNETSVTGEKVGQMEIEDLDEIDRGVPHIFILFGPGSDLFTVSGGTVSVSCPSAMPCLDREQTSAYDLIVVAIDKGGLSSIPVILKIIVDDRNDNEPTIQMPQSELIISNGRIEKPFILKVRDLDTAAFSANKVIADGNASTFLMFERIRNDIYIAKLTSLPKSGKYQLEINVRDSQKALTVQRTIVEVNVLNTITKAHFKRTKYERTLTSEKFFQGNPILQPDFCDVPVENVRFVILRNDPGWLTVDEYTGNVFIGDFLTNIIIDGQYNISIAAINRTDGRILTETILQLKVIGRMQNSIVFNDKFIMKVVRKDPQLTRLAINILPKNNNLSAKSANIIRETVEAIDEKLHSNSIIFEKGDVILDMGKLPNLRSLQFHLNSWKQNETGETTVMIILSSDPVQAALEQRERSRPQFILPWKIDMNLIPVKLAEGSPKGRIIASLPAYNPLDAKKVTNLKLTGEMAEYFSIDGQTEKLIASTESKRLYGESLISDLYDATSASSYADDASNSVVHAIDLRSERNINIPWVEYRKAHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PEK2</accession>
    <name>A0A3P7PEK2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000057">
        <property type="protein sequence ID" value="VDN52400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PEK2"/>
    <dbReference type="STRING" id="318479.A0A3P7PEK2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018239791" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="457" mass="50413" checksum="697A67D0E55D1400" modified="2019-02-13" version="1">MHLALLGFMGVMMVYAMRSSLSFSIVCMVNSTVNGTLIWPKSVQGSVLSAFFWGYTFSQIISGYLASLYGAKLVLGASMLFASLLTLISPFAALKSVYLFLGIRALLGFFQGSTFPAFHTLWSVWAPPLERSLLTGINYAGGQLGNVLVMPLSGFLCKYGFAGGWPSIYYILGFGGLMWCFLWFYFASDTPSRNRRITGEERKYIEESLKETLIKNSSQKYLIKSVMKISSTKFKFKIPWHEICTSVPVWATIIGHFAGDWGSYMMVTSLPLFMNDVFGFDLFSLGFLSAIPYIAYFASINIGGIVCDKLRSAEILSTIATRRLAMCLGLGCQAIFLILSGYCGCNQETLVVVFLTLSIGMSGLQYAGFVVNYLDIAPNFAGTLLGIGNTLSCLAGSLCPLLVGWLTPNGTKEEWQLVFWITGAILIIGTLIFSIFAKGNIQQWLEKFQLITIDKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PIS9</accession>
    <name>A0A3P7PIS9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc transporter ZIP9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PIS9"/>
    <dbReference type="STRING" id="318479.A0A3P7PIS9"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34736" checksum="37B8E694F8346519" modified="2019-02-13" version="1">MYNKICMISYDFSMRGVYLLTFLSVAMFGGSYLAGSVPFAFSMSEHRMRLASIFGAGLLVGTALSVIIPEGVESLYNSITGFFLFDHCIISVNSRTIDLNDKMHGHDGNHSVIHKSVGLSLVVGFIFMLLIDQATRIVTSTGGEKSRYKLTATVGLIVHAAADGVALGSVSMASRSNVQFIIFLAIMLHKAPAAFGLVSFLLVEGFERFRVRRHLLAFSLAAPITAIVTFYILLLVGQQSSSLSFTTGILMLFSGGTFLYVATVHILPELLNSNSHSHHQLNQGEIIGNLSVVHSVFTVKELLAIIVGAILPAFLASHHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PK69</accession>
    <name>A0A3P7PK69_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PK69"/>
    <dbReference type="STRING" id="318479.A0A3P7PK69"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="5">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="208" mass="24537" checksum="295CD0B834B46E10" modified="2019-02-13" version="1">MPPLTDEMRLRCRALPLRTRSTPEFSLVLDLDETLVHCSLNELPDASLTFPVSFQDNTYQVYVRLRPYLHEFLERLSQSFEIILFTASKRVYADKLLNLLDPNKRLIRHRLFREHCLFVYGNYIKDLSILGRDLSKTIIIDNSLQSFAYQIDNGIPIESWFFEKNDKELLKLIPFLENIISQKSDVRTILRARYRIRDLIPSITPCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PP33</accession>
    <name>A0A3P7PP33_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PP33"/>
    <dbReference type="STRING" id="318479.A0A3P7PP33"/>
    <dbReference type="OrthoDB" id="5862080at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="310" mass="36768" checksum="8E6B642C63BCB8E2" modified="2019-02-13" version="1">MCRRLNDITKIIATENHDLSLNPTDSLCFVGWQYSLNRNSKGSRIFEREAVEFLQNHGILPTTMTCRNGHVAKLHFNKHIYWRCSKRTCQRKMRIRSGNWLEGSRIPISTILRFMRCWCEDLTSIEWCQRELKLSKDTTVDWNNRMREVCIFAVQRNKKKIGGEGLIVEIDESLFTKRKNSTSRMLSQQWIFGGICRETGDLFMEEVPDRSAKTLLTVITENVKEGTTIYSDCWRSYTTEELNETGFEDLKINQKYNFVDPKMDIWRNKKHRGTARHQLSTYLAEFLWRQRVRDQDIFLAFLREILSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXK2</accession>
    <name>A0A3P7PXK2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXK2"/>
    <dbReference type="STRING" id="318479.A0A3P7PXK2"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="318" mass="35690" checksum="75C68EDF2FD1E7B1" modified="2019-02-13" version="1">MQIFYIYILIFIYIYIFFFSEISYSRSASISDAVSAIKRNNNVALKGAIQEYDGVESELHGINVSLKNELDLFANLVHIKSLKGIKTRHKKKLDFYIVREQTEGEYSSLEHELVPGIVECLRIITESKCKRIAKFAFDYATKMHRHKVTAVHKANIMKLGDGLFLRSCKEMSALYPRIEFESMIIDNCCMQLVSRPEQFDVMVMPNLYGNIVDNLAAGLIGGAGVVSGQSIGSDAVIFEPGARHSYQEALGRQIANPTAMLLCCAKLLNHVHLKEYGNALHKAVEEVIAEGRVRTRDLGGYSSTSDFTGAVIDKFRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q092</accession>
    <name>A0A3P7Q092_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q092"/>
    <dbReference type="STRING" id="318479.A0A3P7Q092"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="249" mass="28919" checksum="B0D7A6693450574A" modified="2019-02-13" version="1">MISSRTEGKNHFLIWFFRFNNNVLGLGLHRRLFVNTSLGSLNRFINCHLSYRFVIPAGAYVDYDTLPQISSYRIAEKHFDIEAAREASKDEVVYVCSNKVLRKNFIYHEEFAFPFHIRYHRASNASANVTLQSPKILIRCENNDTFLNNGSCTKWIKKMGIVNYENIFINMKKLFSEFLFFQAPCDCKTSQKCNWIFLKSTFSNKVTLSVPTGNYESQTIIFVVTFFVVFLCILAIVINSIFDKKGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q2E7</accession>
    <name>A0A3P7Q2E7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q2E7"/>
    <dbReference type="STRING" id="318479.A0A3P7Q2E7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="199" mass="22503" checksum="962FF78A3AE2BDE7" modified="2019-02-13" version="1">MRSPFGSTPQPLKQRDISFDTSSKEPHLIRARVFVGNINTNVITRDDIIRLFSSYGNLLGVTVFKGYAFIQYGTSTEADLAVGVLNGYNWNGSILGRIIFFLSSIFRGGVKRTADNWPNNVVKKEKLEDFSVVMAQNDRNRQTASEDITRNCNLYQTGMPDTLICGGCRFVTSDFEEFREHRKAACVTDLKDLKKERVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q686</accession>
    <name>A0A3P7Q686_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS994</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q686"/>
    <dbReference type="STRING" id="318479.A0A3P7Q686"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF818">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="64"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="350" mass="40099" checksum="3DC0C59E2ADA1C18" modified="2019-02-13" version="1">MFKVVDKSKKDSETSLSPVDFANVPKREIDLKSLGINVKPDPTLGNKIEGDIAVDAFSSRFRRGAVRQSFRRWPDGEIPYAISTQYGPYSRSIIANAMQEYHKKTCLRFVPRDPLRHRNYIYIYPDDGCYSLVGKSGGRQPLSLDSGCIQTGTIVHELMHVTGFFHEQSRSDRDKYISIIWENIMEGAEDQFEKYGTNVVDLLGEDYDYSSIMHYGPYAFTGNGRRTIVALKPGSGDMGQRRGFSTLDMKKLNKLYSCSDKTPSITTTAKPTEKCEDTHWRCVFWSMSIFSYCERSKQIAQVECRKSCGNCDSKLVEIEENKTNGFLFVRYFIIIFYILYFIINKIDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q7V5</accession>
    <name>A0A3P7Q7V5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q7V5"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004951">
        <property type="entry name" value="DUF268_CAE_spp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03269">
        <property type="entry name" value="DUF268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16611" checksum="2012CFABD12C0C73" modified="2019-02-13" version="1">MFEKLSKLSTSAFYAPFLTQSYFFAFNSSLTLKKKNKKFEKIYRKKTLSIFSYSEAFDFVVTFSSIEHSGLGRYGDPIDPISDIREIKKIRCLLKKKGLLFLAVPVGNDEIHFNAHRVYGRIRLAMLFEGSLKFENFLEGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QF30</accession>
    <name>A0A3P7QF30_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000152">
        <property type="protein sequence ID" value="VDN53607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QF30"/>
    <dbReference type="STRING" id="318479.A0A3P7QF30"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="148"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="373" mass="41818" checksum="6FA85A9BEE0B851D" modified="2019-02-13" version="1">MAEKTQNLRRLHAQRNELNSKVRMLKEELQQLHEQGSYVGEVSKAIDKKKVLVKVHPEGKYVVDVDKGIDIANVNTGCRVALRADSYSLHKILPSKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFDALGIEQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPAPDEKAREDILKIHSRKMNLMRGINMRKIAEAIPGASGAEVKYSVCTEAGMFALRERRIHVTQEDFEMAVGKVMQKDSDKNMSIKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SE55</accession>
    <name>A0A3P7SE55_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SE55"/>
    <dbReference type="STRING" id="318479.A0A3P7SE55"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF41">
        <property type="entry name" value="MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="3"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="60" mass="7128" checksum="34D3F9D1E871D6A0" modified="2019-02-13" version="1">MTSTQIKIWFQNRRYKCKRIDQDRTLQLSSQFAFPNQVIISVPYANLFCLISEICDQILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SJR7</accession>
    <name>A0A3P7SJR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000757">
        <property type="protein sequence ID" value="VDN54352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SJR7"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="51" mass="6410" checksum="C951865F5FD5A98D" modified="2019-02-13" version="1">MYNAQPLIQIYAPISIQKRVQPYSRWWSKIHFQTNLIRKNRFFAYLIYFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SNE3</accession>
    <name>A0A3P7SNE3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chondroitin proteoglycan 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000062">
        <property type="protein sequence ID" value="VDN52489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SNE3"/>
    <dbReference type="STRING" id="318479.A0A3P7SNE3"/>
    <dbReference type="OrthoDB" id="5826574at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029153">
        <property type="entry name" value="CPG4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15481">
        <property type="entry name" value="CPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chondroitin proteoglycan 4" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="144" mass="17396" checksum="67FB1B172578BF34" modified="2019-02-13" version="1">MWICAKPLNSFERTYHYLFTNFDKVCEKLEKSAHCSRKCQMKDQGIFYQYSTFYRLHCIEFEEGLNLIKIKKRFEDLKSIFSIFCSEFNDASKLQNLRNIVDCFIDLSQIYEEEKQRSERCRLIIKFPSILQFFSTVGTTFIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SV47</accession>
    <name>A0A3P7SV47_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4270</name>
        <name evidence="3" type="ORF">DME_LOCUS4352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000546">
        <property type="protein sequence ID" value="VDN54297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UYYG01000937">
        <property type="protein sequence ID" value="VDN54379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SV47"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="63" mass="6707" checksum="2B5D35C7B2BCBF6C" modified="2019-02-13" version="1">MMPVPSTTPRRYEMSPVLEEYIDAGATLPARRAPQAKVAAQQPPASGDGTNIAAVRQNTPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0U8</accession>
    <name>A0A0N4U0U8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4552</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0U8"/>
    <dbReference type="STRING" id="318479.A0A0N4U0U8"/>
    <dbReference type="WBParaSite" id="DME_0000019201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000019201-mRNA-1"/>
        <property type="gene ID" value="DME_0000019201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000019201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="63732" checksum="05F9419E1B5C588D" modified="2015-12-09" version="1">MLALYSTTVGQQRCVTGSRTQNLSIVETQLAAVAPKEYVGYFVATYCKTTQTDDDRISAGEFSLGSQEFDYDEEMNIMDKHLDINFDESPTREIANILPSFQFKIRQQLDANEEIQEDEQKVPDLSEEEKLQILSSQKFQQFFDYSSRVMERQLAEETDMFIDYSHGGATDEKEDSGEKLILSRVFVDPKWSAGRAITGIDNCEQYPELIAVSYDQNPESPLDPAGVVQVWNNRFKKTTAEYTFYCQSCVTSVAFARFHPNLILGGCYSGQICMWDNRLNKKTSVSKSPLSSQAHTHPVSSMAIVGSQNAHNLISVSTDGRLCSWSVDNLNQPIDVIDLSWNKKQVTCTSMSFVLDGVNNFVVGSEEGNVYMASRHRNKGDVNGSFEGHTGPVTCVDTHKASNGVDLSHLFLSCSCDWTVKLWSSKEPKYLCSFEKHGDYVMDVAWSPVNPSVFTSADASGNLFLWNLNEDIEAPITKLQVEGGVGVRKMMWMQNGHQLAVGDERGNLWLYDVHESIANCRPSEWTSLARTLRDMKQANEEAEELFEVMNKIGSSAVPTITSVATGVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1G0</accession>
    <name>A0A0N4U1G0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4802</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1G0"/>
    <dbReference type="WBParaSite" id="DME_0000044201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000044201-mRNA-1"/>
        <property type="gene ID" value="DME_0000044201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000044201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60180" checksum="032F01D57A8DD88B" modified="2016-06-08" version="2">MFAQQTNIIRIDVIRNLSHILNDIWARVGPITISTLRKVYFTAYGVDLDKHCELGGFTLIEILEDKFNNEFYFNRELSVLEPRFVGNVFIASQNIQPFSDVPTSVVNYGSNFSLPPPGQPLFQSVVPMPPYQLFSPSYRVIPKLPNFVPPSLNYSTKNNGQFVSNTTRKSMNRVDIFNSLRDIIIDILNLPEHKRGITEKELMEAVRQRDSNIPLQLINFQTFFSNFMSDFIEKSGNLYRRRQSQIIIQEENIGDEEIPVNVKNAESIKNAATEECSKHNDCAVSPMEKCEESGKLVLQKSAKVNGEDPNDNNISVIDTVYDCTELLLDWRKNANSLQSLFEFLLVVNANYKENSGRFSDREFYDRFGNALFDRFNIFDLSDLVNSDLLKVERSNGELFYFVNSEIEYLTSADFIHLKKQLLHRFSIDSSVNFDTLLRLLKFPEEKYKSDLDKAAMLWAVLSRLPSDFDIQAVSRTSDLSELRINICPLPYEILLFDKLDYRHCSNLRNVQVNPEYQNMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1I6</accession>
    <name>A0A0N4U1I6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS4831</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1I6"/>
    <dbReference type="STRING" id="318479.A0A0N4U1I6"/>
    <dbReference type="WBParaSite" id="DME_0000047101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000047101-mRNA-1"/>
        <property type="gene ID" value="DME_0000047101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000190">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="908"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="954"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="730"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN54858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000047101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="117622" checksum="FB5F7585EB491031" modified="2015-12-09" version="1">MKKKCFYFSARQIPDVSPTGRYTTAVPFLIILSISAVKEIFEDIKRRKSDQKVNNFQTRILRNGKWERKRWKHVIVGDILRIENEELFPADMILLSSSEPQAMAYIETSNLDGETNLKIRQGLSCTADFTSLQSVASAKFAIECEKPNRFVNEFNGTLHMQNLHRPLRINQLLLRGARLKNTQWICGAVIYTGHDAKLLMNSKTAPLKRSNVDVMTNRRIIFLFFVLVALAIISAFGALLFDNVWLVNAYYLGLEGSQRSTFFWNVLAFFILYNNLIPISLQVTLELVRFFQASYINNDLQMYDEATDTPAVARTSNLNEELGQVKFVMCDKTGTLTRNVMKFKRCSVAGMNFGKDDEDDFDDPSLIECLQTSSENTTIAEFLRMMAICHTVVPEKGNENGIIYQASSPDEGALVRGAASLGFIFHTRKPEFVVINAMGKEEIYEILNILEFTSDRKRMGVIVRCPDSTIRLYIKGADSVLFDRIRGDSPYKDKCVEHLIEYASKGYRTLCFATRIIEDSEYRNWSADFEAASLAIDNRGIKMADCAELIEKELILVGASAIEDKLQQQVPETIKALMDAEIRIWMLTGDKRETAVNIAFSAALCNSESIPLCLDTTTYNETISRLTTLIKHAEMFRQSDSNVMLIIESTSLHYALTGDCRPLLGELALLCHSVICCRMTPMQKAEIVELVRSCGEHVVLAIGDGANDVAMIQAANVGVGISGEEGLQAASASDYSISQFHFLRRLILVHGTWNFDRCVKVIFYSFYKNICLYLIELWFALFSAFSGQTVFERWTIGLFNVAFTALPPIILGLFDRPIADSTIQKFPALYFSFHERAFSIKQFAFWISMAVWHSLILYFFSFLFMYNSTVWGNGRDAGWLMLGNSCYTFVVATVCFKALLECDSWTHIILYSIVGSIALWFLFLAIYSALWPFIPLGDDMTGMAYIMISSPNFWLAFFLIPLFALLFDFIFKVYAFFLFYVSIRITVSPTPRELLCIKEYKSRDRVMELSGYFIFFFDKFHLHNLFSFNSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1P2</accession>
    <name>A0A0N4U1P2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4896</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1P2"/>
    <dbReference type="WBParaSite" id="DME_0000053601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000053601-mRNA-1"/>
        <property type="gene ID" value="DME_0000053601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6365737at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000053601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22543" checksum="AB91341B4447E564" modified="2015-12-09" version="1">MGEEVNRKRYTSDEMRQIASNMKEENDWWRFIASFNKIGRSNKKCKMNKMAPPSTTNDPCGLKDLKKNDFYDVIASDIFFEVTDLQNPKAVHIRKDSLEESSNILKHEIFTKKLSINKSELKEIESVNHIQVPNEEKVCICHRPATTVKCCECGTEFQGHAERTCNEHPRRINLMDIRECPKCRSRLLEELYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2P5</accession>
    <name>A0A0N4U2P5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2P5"/>
    <dbReference type="WBParaSite" id="DME_0000096501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000096501-mRNA-1"/>
        <property type="gene ID" value="DME_0000096501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792993at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000096501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31770" checksum="C371FFA6FE1DEBD5" modified="2015-12-09" version="1">MPLIRERQPMAATSPLYLHYYSIAYSMVITAYVFGFGEYIFFRLSWMINSKKTPYYAWCDKRAREVVGKNFIHYIVVIIGFIAIAFFQITCFFGLTISENWIHCTKKSRIDRMIRVRRALSSKIRTVMQKTIYPTFVCYMMSSMVIWAVIFYVDGIRDSIDELASTICIYIFDFIMVVYFLAFPAVTYIYHPYVRKRTSSPPIYANPGDNSVSLMNDNEIHCGGSPVGSVPNIAMELIACGWKNFQSEDYPPSTFSPPNVSGQRFIRNIKLTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2R0</accession>
    <name>A0A0N4U2R0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carnitine O-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS5341</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2R0"/>
    <dbReference type="SMR" id="A0A0N4U2R0"/>
    <dbReference type="STRING" id="318479.A0A0N4U2R0"/>
    <dbReference type="WBParaSite" id="DME_0000098101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000098101-mRNA-1"/>
        <property type="gene ID" value="DME_0000098101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000042">
        <property type="entry name" value="Carnitine Palmitoyl Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="19">
        <location>
            <begin position="174"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN55368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000098101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="758" mass="87157" checksum="931C26A97CCF53A3" modified="2016-06-08" version="2">MAEAHSVAALSFTITHDGVSVSYDQELMRDIWHAFSRAYKRRIARFKNDFLAGIFPVNATTFCLVVFALTFFSVFHRDLSFGIVPFVRHYIFGFLFGDGYFSQILALITCGSLIWFTAIQTLRLCLKSLLSYKGWMYEEMGSISRSTILWMKILCLIAKSKPMLHSFQGALPRLPLPSLDDTLKKHLESMRPLSTDEEYGELVELSEKFRRGLGSRLQRYLYIKSHLSINYVTDWWEEFVYLRQRSPLMINSNYYGFDTINHIVTTNQAARAANLTNAALLFRRKVERQEVSPFSVAPRFNVPFCVMQYERLFNSCRVPGEEIDQFLHRNDSKHIVVYCRGCWFRLAIHNGKRLYEAAELQQGFQAILDDDFVPEHGEENIAALTAGDRKAWAEVRKKYFSFGVNKKSLHLIESAAFVVILDDNEVFYDPKDSSKLDSWARHLLHGSGTNRWFDKSLNIIVFKNARMGMNVEHSWGDAPIAAHFLEYSLLVDLFHQGYDKDGNALGGVVQIPKPERLRWNLQNEIHTVINSSLSLARTLINDVEMALLIWTKFGKGLIKNFKVSPDAFIQMTLQLTYFRNQGHFALTYEASTTRLYREGRTETIRSCTKESCEFVRSMMDPERTRKERAQLLRIACNHHQNAVRDAMCGKGIDRHLFALYIVKRYLEEESPFLDKIFPPTYLLSTSQTPINQCKEEAAILTEAQKMKIFTAGGGFGPVADNGYGVSYIIVGEDHIAFHISSKKSADNTVRIVFFKIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Z8</accession>
    <name>A0A0N4U2Z8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5441</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Z8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Z8"/>
    <dbReference type="WBParaSite" id="DME_0000108101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000108101-mRNA-1"/>
        <property type="gene ID" value="DME_0000108101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000108101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14492" checksum="B1AA0F228A6C8BCB" modified="2015-12-09" version="1">MVNVPKVRRTFCSGNCRKHTVHKVVQYKKGKESSYAQGRRRYDNKQKGFGGQTKPILRKKAKTTKKIVLRMECSDCKHRKQLAIKRCKHFELGGQKKARGQVLIVFCFFLFLIVMNKVNMYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3B7</accession>
    <name>A0A0N4U3B7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5576</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3B7"/>
    <dbReference type="WBParaSite" id="DME_0000121601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000121601-mRNA-1"/>
        <property type="gene ID" value="DME_0000121601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810331at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000121601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6396" checksum="E769CDBBA04A6534" modified="2015-12-09" version="1">MPGAKYYDGKKISLPVNENATFLLYDYWINQAISAFLASFATEKYHCLLSLNFTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3J1</accession>
    <name>A0A0N4U3J1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5656</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3J1"/>
    <dbReference type="WBParaSite" id="DME_0000129601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000129601-mRNA-1"/>
        <property type="gene ID" value="DME_0000129601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872270at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000129601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15608" checksum="0707C0098911EB6E" modified="2015-12-09" version="1">MAYDPRRSSINANIKHSLCNEARGSLSSQVKCPLQGPLNPPKRSSATSTGGQLFLCLIGSLLSFSICIWLTVFSQDVQWRRFLFAGGAALCALLFAMLAIQTVRKAKQVPTEEVIPNLAHRRSTIARSARKSICSGTTQEGTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3M1</accession>
    <name>A0A0N4U3M1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3M1"/>
    <dbReference type="WBParaSite" id="DME_0000133001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000133001-mRNA-1"/>
        <property type="gene ID" value="DME_0000133001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874211at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000133001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12579" checksum="1994789A217AE020" modified="2015-12-09" version="1">MKKLKRRITAAFRCNTSPSSTQIGDICYHRNWSLSDSISEIAERLAADGIIIEECDASVGIQKKESKRERFILFNGSGKSGSKSISSDYIRCFKPFPQRWHSTNSFISSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U491</accession>
    <name>A0A0N4U491_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ADP,ATP carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5948</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U491"/>
    <dbReference type="STRING" id="318479.A0A0N4U491"/>
    <dbReference type="WBParaSite" id="DME_0000158801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000158801-mRNA-1"/>
        <property type="gene ID" value="DME_0000158801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000158801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11222" checksum="2A0AB0CEB8EF8362" modified="2015-12-09" version="1">MVDLKNCMMYIPNGIAGVLAGHPLDTVKVQLQTQAPGQYTGTIHCFRSIIKNEGIAGLFKGISSLLATLSFTNAIIFGDSLKISAASISVMLLSYSRKYNRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4D1</accession>
    <name>A0A0N4U4D1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5993</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4D1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4D1"/>
    <dbReference type="WBParaSite" id="DME_0000163301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000163301-mRNA-1"/>
        <property type="gene ID" value="DME_0000163301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000027">
        <property type="entry name" value="Zinc transporter ttm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="228"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000163301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34856" checksum="09D726BA95EF27A7" modified="2015-12-09" version="1">MEHKRAERTLYAVSLLAFLFIITEFFGGYFANSLAVMTDAGHMTTDLLSFLISIAAIKLARLKPTKIYSFGFHRAEVLGALLSILTIWILTIVLVYLAVERIIEDNFEVDANIMLITACISIIFNIIMGIILMIGKNSHSHFGMSHSHSHDGNKKMQQQSNINVRAAFIHVLGDLVQSFGVLIAAFIIKLTNFRLADPLCTFFFSFLVLITTLPVLRDALIVLMEATPRHINVDEIHRDLLSINGVQSIHSLRVWSLSIDKTAVSVHLNTDKDCDLDHIIHEANERLRLKHDIGYRTVQVKHFIPIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4N0</accession>
    <name>A0A0N4U4N0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6109</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4N0"/>
    <dbReference type="STRING" id="318479.A0A0N4U4N0"/>
    <dbReference type="WBParaSite" id="DME_0000174901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000174901-mRNA-1"/>
        <property type="gene ID" value="DME_0000174901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000174901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26723" checksum="435EE466FB4D70A6" modified="2015-12-09" version="1">MDASTLNISGPCTVISRALRPYFDETLQKDDYFDVNKLVDIGALFKARVHYGHKVGTLNEKMKWAIIGERLGISIFDLNITRTYLIRALDFIAHIAYRGGLFLFITSNRENMLMVEKRARSIGEYAHVRKWQEGTLLNSKQLFGVTVRLPDTIIFLSTLTSVLETHPAVIEAAKMTIPTVGIVDSNSDPAYITYPIPGNDDSLVSIEYYMNLFTAAIRKGKIARSSINVSEKIKVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4N9</accession>
    <name>A0A0N4U4N9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6119</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4N9"/>
    <dbReference type="STRING" id="318479.A0A0N4U4N9"/>
    <dbReference type="WBParaSite" id="DME_0000175901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000175901-mRNA-1"/>
        <property type="gene ID" value="DME_0000175901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000175901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23015" checksum="051B8784B957C429" modified="2015-12-09" version="1">MRRSDTSHLTTCGFHESRLVYEGAVLVCECEGCIINVYFRYEILQYVSHLNLHIGLFDETDRDNKRTYKCRWKARLLREHCSRHVVNLKCERCAIMVGSPSALHRHILTVHKQKLTLKQKLYRCLRNEISLAETNHKLTNHDYSPYTHLCHVCFAKYTNGFGLTRHLKVKHNFTIPTGFTRFQYKKCADVVLADTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4X0</accession>
    <name>A0A0N4U4X0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6219</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4X0"/>
    <dbReference type="WBParaSite" id="DME_0000185901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000185901-mRNA-1"/>
        <property type="gene ID" value="DME_0000185901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000185901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11401" checksum="2019FF259895128F" modified="2015-12-09" version="1">MVFPLLGRFPMLVDLQSFPQQFILRCSISEFFPGFVQDGFHIHQPHSPSFLSVGLREIFVHCEEFPDLYISNPISPFVQLIVLGAYIYGIDFALPIDLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U542</accession>
    <name>A0A0N4U542_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6306</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U542"/>
    <dbReference type="STRING" id="318479.A0A0N4U542"/>
    <dbReference type="WBParaSite" id="DME_0000194601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000194601-mRNA-1"/>
        <property type="gene ID" value="DME_0000194601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001216">
        <property type="entry name" value="Splicing factor 3A subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000194601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27190" checksum="BA24DB85BE560790" modified="2015-12-09" version="1">MDFQNRAGGKTGGGGVASWSDANVDRRERLRQLALETIDLQKDPYFMKNHLGGYECKLCLTLHNNEGSYLAHTQGKKHQANLARRAAKEASDMPYMPTPQQVKIEPKKFVKIGRPGYKVTKERDPATGQQALLFQIDYPEIAEAYEQKVQPPDKRWQYVLFAAEPYETIAFKIPSREVDKSEEKFWTMWNKDTKQFFMQFAFRSDRSLHDEMLPPPPGSMLPRPGAVPPPMFLPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U594</accession>
    <name>A0A0N4U594_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 149</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6367</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U594"/>
    <dbReference type="STRING" id="318479.A0A0N4U594"/>
    <dbReference type="WBParaSite" id="DME_0000200701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000200701-mRNA-1"/>
        <property type="gene ID" value="DME_0000200701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917629at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="119"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000200701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38429" checksum="80BFE819B8CA574C" modified="2015-12-09" version="1">MIGNNSKVINEIESLQKKCAQKTEVVLSLSKELSVTQSEVNKWKAIAENFERNLAQVEFSLQTLTKADVKDLRSDCKVLRQKIARYEVETFYKIGDAQENYDTREGAKDMPKSIAINDSNIFIENLEKLTNKNSQLQKDLQALLCEKEELICDRDSLNRKIERLSQELTYLLNGDSNRIIDDIDGLIAENRYLKAQLKNAEEETGLTRATLKKYHKMIKNKIKVSLTDNATKSNGNRISAYDAEQIHKVIGSKALDLSNCDYSSLMELLLDLCNDRQIALAHQRNSNKILGERIVELDAKILHMNCTEKSPSRLSPRSPFTHADVGIQYDFQDLQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5C4</accession>
    <name>A0A0N4U5C4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6400</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5C4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5C4"/>
    <dbReference type="WBParaSite" id="DME_0000204001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000204001-mRNA-1"/>
        <property type="gene ID" value="DME_0000204001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000204001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38563" checksum="44E771B5EC9DB139" modified="2015-12-09" version="1">MCLNFFQIGSWSYPLELVRLFVDQKEVFLGDFYDNQEWLLENATLYNGTMDYLNNQSFSTIFMELILRRQSFYYVFNYVFPTTLVSLVAVVGFHAPINATGRRESKFRLGIMTLLSMSVMLLMLVNEMKFALASIPGQRGSFSDVPLLGVFHMIQMLIISVATCTSTAFVLLEKYALRNQYFHAIPWWLRFLTGKKLFCCYVPTKFRLARNEKIERNHNISTRFISSTSADSATFGNIIPAEANFIECHRDAAATEATIDCPPPLTNQRIELLVSLMREFIQMKKEMQKRHNYPNFWERVLSRLETISLITFLFFIFLNVTMFMYAELWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5C6</accession>
    <name>A0A0N4U5C6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6402</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5C6"/>
    <dbReference type="WBParaSite" id="DME_0000204201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000204201-mRNA-1"/>
        <property type="gene ID" value="DME_0000204201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260275at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000204201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12096" checksum="541FB9640AB956C5" modified="2015-12-09" version="1">MLLTERRLRWLGHILRHPSQELTYISLFAKRCDGWRQKRGGPTWTDTVRKDFERIGEPAIYGFRRWKKEWLPLLSTMASDRAAWKRLTLVAIGASLTSYGESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5E8</accession>
    <name>A0A0N4U5E8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6427</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5E8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5E8"/>
    <dbReference type="WBParaSite" id="DME_0000206701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000206701-mRNA-1"/>
        <property type="gene ID" value="DME_0000206701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10169">
        <property type="entry name" value="ASKHA_NBD_actin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000206701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59638" checksum="68373AC769A90032" modified="2016-06-08" version="2">MNKFQISYEPRKAAKNRKFINMEGHLDVPIKDEKIIAELQKNWTEKYFRTKDGRLQWFASHFADDHPIGEILLSGCETDTNKDEGLISIRGGPDHVNFLIRVPPPTNLLDKWRRAINSHTSSIHDDTYVNPVYPPFPHIVEKTVIIELGSCSIRAGLLTMNPSLPQVFFPTLALIKSNGVIVVGADAFIVMNLHDGELMRPIKAVGPSLERYSINKCAVEACLRKCVLDLHIDPRNYKVLLSIPQNIPTILISEILKIALQDIQFQSAAISRQPSLVLYAYDVTTGVVVDIGDRLNIVPIIDGYVVDNAIVSLPYGASQIADSLHQKLCEANMGLYSGRAPIERLILRYVMEQACYISTDFDKEIGEYSDKESEIDMVVSLDEFKPSGNMNRSFKLVLFCEVAVIFKVNSARFTAPEGFFKPKRWGLDTKALHEHIYEAVQSSPIDSRKILLRNIYLAGGVSLLPGLAERLELEIGSLIAPTIHAQVHVSPWRYHASYLGAQVIASSSQFDQMCITAENLDKFVIQLQTATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5T1</accession>
    <name>A0A0N4U5T1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6587</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5T1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5T1"/>
    <dbReference type="WBParaSite" id="DME_0000222701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000222701-mRNA-1"/>
        <property type="gene ID" value="DME_0000222701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407103at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000222701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34370" checksum="6E72FDD03D206D35" modified="2016-06-08" version="2">MRQIIANFIQFHLNKYKKYWLAAISTVLIIIIANNSRYNKTRYLETRDWDSLNLIEICRNDLLRMAESLEFADLEQHYNYFHPFARFLCRYRFNRQISILEMGVGGYTKKTEGGNSLRVWHQFFPNAKVIVGVDISEKQLDLPDNVKIIQMNASDESMATRVCDFYGPFDIIFDDASHISYDVIRSFEINWQCLRSDGIYVVKDTQTSYLEFFNGSKNLNDPKTSMNYFKSLTDQQNYAEILISNPLFKPMDKAKQLLGIHFYHNIIFIEKGDNTLPSNLAPNRNILQKFSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5X7</accession>
    <name>A0A0N4U5X7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6644</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5X7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5X7"/>
    <dbReference type="WBParaSite" id="DME_0000228401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000228401-mRNA-1"/>
        <property type="gene ID" value="DME_0000228401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000228401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9428" checksum="018139A5786E7A3C" modified="2015-12-09" version="1">MEQNDIQSGKLEDNLLSVPEDQNPKNVQDLTGLIQGVLKQTQERFKHMSDEIIGRIDTMSKRIDELEKNITELMAQSGLDVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U612</accession>
    <name>A0A0N4U612_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6687</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U612"/>
    <dbReference type="STRING" id="318479.A0A0N4U612"/>
    <dbReference type="WBParaSite" id="DME_0000232701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000232701-mRNA-1"/>
        <property type="gene ID" value="DME_0000232701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000232701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13437" checksum="7C408B9F1092E81F" modified="2015-12-09" version="1">MKEESILNLNVPLILVGDIHGQFKDLLRIFEINGYPPTVNIHSQQLIFPLSHTYYVDNLIYGFYDECRLRYTLEIWNLLQAIFNCLPLYARINKNILYAWRNITRHCVMKFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6H2</accession>
    <name>A0A0N4U6H2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6880</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6H2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6H2"/>
    <dbReference type="WBParaSite" id="DME_0000252001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000252001-mRNA-1"/>
        <property type="gene ID" value="DME_0000252001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9996608at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF29">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000252001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8606" checksum="6E905FA72242E53F" modified="2015-12-09" version="1">MSERNKEFCDHSWSNGYHFGALSCAACSAFFRRSVSECRKYFCQNADARCFCRACRLKKCLEQGMDPNCKLKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6H6</accession>
    <name>A0A0N4U6H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6884</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6H6"/>
    <dbReference type="STRING" id="318479.A0A0N4U6H6"/>
    <dbReference type="WBParaSite" id="DME_0000252401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000252401-mRNA-1"/>
        <property type="gene ID" value="DME_0000252401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000252401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57384" checksum="751F003CD80A2703" modified="2015-12-09" version="1">MDSDRSDSSISAVSSNSELSPNLLTFPTTMDLNYGDFPIKQKQKFIKNVDEIFDLTSQYGWYQFFVLLTIQYAMMKDVCDLVSNCPANETERFFVSLYEEDGIVCPNSHLPHHLQTIQAIGSAIGALSAGHIADRYGRKWVSYSGMLQMIIFGISGSLAINWIMLALAMFGMGFSYGIMFDASMTLACETVGAKYRIVQNLAFQWSLTIQIASLCAYLTGSWRKYLLVINTLPLPLLILLLFWIESPRWLIQQKRYSEAVNNINRISQWNNSSIIIKNEDLLHIKVDNRQSGSICALFANEKMRKYSFVMFLAALTVEMCVAVILFDVQILVGNPFLNVALYGILRIWVPLFIILLEINTSWFGRRVLYMSSQGATLACYVLILILSFSPQNYATKLLKTCFAIFGGIINCSIFFTIYKQYVMELYPTVIRALAVGAFGVIERIGGAIGPQLINMNQSVWPHSSITITTLVLLSSLVAGYIILPETRDQSMPDVLEQTNFKCRRNREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Y7</accession>
    <name>A0A0N4U6Y7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14 17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS7082</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Y7"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Y7"/>
    <dbReference type="WBParaSite" id="DME_0000272201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000272201-mRNA-1"/>
        <property type="gene ID" value="DME_0000272201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF172">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230505" evidence="11">
        <location>
            <begin position="17"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="155"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="270"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="374"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="713"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="811"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN57109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000272201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="932" mass="103236" checksum="E64D42F6E851BD6F" modified="2015-12-09" version="1">MVFASVFNLATTLSLSCFYASQFCNNQTLSVPNPPPIIEHGHSNQTLMISASAILPCQASGRIAPIISWLKDGETIDMNDPSYENRFKQLAIGSLQISNLKKLDTGVYTCRARNDDGESTWTASLIVEGEDFFEDHTNPLVTFNRMPDISTFPTAPGKPIQVNVSDDNVYLEWTPPEKSGATIITGYILQYFSQEMGKTWFNVPEYIPGSRFRVKNLKPSSSYRFIVRAENSNGIGPPSPVSEVIRTNAAKDEVISGDASIFIARQRLAAEQLLKLDEVKKVNSTAVRLFWKRRRVEPLVQGYYIKWRILSSNSDNFHNNWVNVTDGNVDSYLVNGLKPFTNYEFFVIPYHKSVQGMPSNSLEGSTDEAPPTAVPTDVRVRMMNLTTLRISWRPPPAEGINGILKGFQIVILGNGAKYNRNITTNERAASVTLFHLVPGMTYGVKVAARNNAGVGTYHGLEAVTMNEATLREHIALLAGASSSDRILYLVRKPWFIAIAGVFAWIVFVAIITVVWWRWRRSRGKAAARLGMPFIKINDGSVHLTSRDALWMDHSNLMSAQRSLLLNSSINGANYSGPPVYTKTPHQGDFCSDGQLPDRHYPSNLLGTIDRSQSPHHYHYAALSNGPSPPAISTFYGGRQHMDDPSPYATTTLVMNNRQNWLKDHMLRCPALPSIPVPSGPPPRFQDFTMQTKNEHFASAHSPSVIKTKKNECIHQSTSPPHTDVSYVQSSSDGTGGSSNGQNKTTVGKERRQTPKETLLEILPPPPSSLPSDNTSNKVTRGVNESVNCRLVDSEHYDAVSDALLFDRNSRYTSSHVPNNRLNGYRLGPTGYGGGQEDDDSQRSSLMLDGNGRTETLSSSEAGEESWERDEDCTINRRIDVSQNPESTPNRPSQPCMGISASTLSQNACDSFNVKHSTSRLKSLPRNVKNDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7M7</accession>
    <name>A0A0N4U7M7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T3SS_YcgR_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7156</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7M7"/>
    <dbReference type="WBParaSite" id="DME_0000299701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000299701-mRNA-1"/>
        <property type="gene ID" value="DME_0000299701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000299701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12095" checksum="D5A75B402D0851D4" modified="2015-12-09" version="1">MEIADSGEGWMRIGIKSIEYSGKYFEAENPQKRLDAVFIGNTRVLNVRLENLRRSYNKLLVELSYLPVDRETLSQCMFKQHEVDFIPLTKVKFSLESAIPLALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U839</accession>
    <name>A0A0N4U839_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">COX3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7344</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U839"/>
    <dbReference type="STRING" id="318479.A0A0N4U839"/>
    <dbReference type="WBParaSite" id="DME_0000318501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000318501-mRNA-1"/>
        <property type="gene ID" value="DME_0000318501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855657at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="5">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000318501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="15081" checksum="AF8D23A128AA825B" modified="2015-12-09" version="1">MFFLEFFAVLSLKYGAVFRLFFNIFFWCKDIFMEDYHNYHNFFSKYDFLGFFDSSLVPNRELGMSWCPLGIGFINPMGIPLLNTLIESGFSMSDGIYVFLFVNLFRLYMDHFNRDHHMGLEFSIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Y9</accession>
    <name>A0A0N4U8Y9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM32A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7534</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Y9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Y9"/>
    <dbReference type="WBParaSite" id="DME_0000352901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000352901-mRNA-1"/>
        <property type="gene ID" value="DME_0000352901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000352901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11978" checksum="268F249C911CBDE7" modified="2015-12-09" version="1">MRKEVVVKGALQLKKGGKIFKRKKKDNVDLRNIDLTIHRENNALNTHKTSAELAFEKRQQENQFDRLIKKASVSHREKVEKFNAQMSELTEFNDIPKVSWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Q4</accession>
    <name>A0A0N4U9Q4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7837</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Q4"/>
    <dbReference type="STRING" id="318479.A0A0N4U9Q4"/>
    <dbReference type="WBParaSite" id="DME_0000383201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000383201-mRNA-1"/>
        <property type="gene ID" value="DME_0000383201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053321">
        <property type="entry name" value="IPP-5-Phosphatase_Type_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000383201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="33084" checksum="885A7C697AC1B575" modified="2015-12-09" version="1">MSLTFYFLESLMDSYWIYCWVRKWSQMIILLIRSTILHYLSVPEWKFISSSTITKPIRTKGAIVIKFKLFQATFLFIGCHLSRLSYVFWLGDMNFRLISRRRLDEIVRHFDQPSGEIMFTHLLSDDELTIGRNQGIFFKNFQEPMIRFPPTHKFIVNSNEYVCNRIPSYTDRILYHCKKSKQINSLKYDIMWEENASDHKPVYGLFAVTTWIFERIFISVEVKLQVNQVEGHSKMKLKILSIFLQLSITEILFKRFNNVCLSDFLYIRENFEKVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9U6</accession>
    <name>A0A0N4U9U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-Tim10_DDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7885</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9U6"/>
    <dbReference type="STRING" id="318479.A0A0N4U9U6"/>
    <dbReference type="WBParaSite" id="DME_0000388001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000388001-mRNA-1"/>
        <property type="gene ID" value="DME_0000388001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6365952at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018251">
        <property type="entry name" value="Crust_neurhormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01250">
        <property type="entry name" value="CHH_MIH_GIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000388001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11475" checksum="604FB187D6477D9A" modified="2015-12-09" version="1">MLNSSFSRIIQLLRTQQKRGSEEWIKWDPNCSIYRNEELHAIMDRVCEMCHEMFSHEQTNLRAECRKNCFRNKKFRGCLQLFSPAEEGWWKDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9V8</accession>
    <name>A0A0N4U9V8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS7903</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9V8"/>
    <dbReference type="STRING" id="318479.A0A0N4U9V8"/>
    <dbReference type="WBParaSite" id="DME_0000389801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000389801-mRNA-1"/>
        <property type="gene ID" value="DME_0000389801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000554">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN57930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000389801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18679" checksum="066B835C111084F6" modified="2015-12-09" version="1">MRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVGEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEVTDKLGLHTLRNRNWYIQATCATSGDGLYEGLDWLSNQLRNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Z0</accession>
    <name>A0A0N4U9Z0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS7940</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Z0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9Z0"/>
    <dbReference type="WBParaSite" id="DME_0000393501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000393501-mRNA-1"/>
        <property type="gene ID" value="DME_0000393501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN57967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000393501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13496" checksum="5173B72FB2661BA1" modified="2015-12-09" version="1">MPIVTIATNLPENHFMEDFNVQFTRALSEIIGKPVDRISVQLTTNARLTHAGTNQPTCTIVIKAIKAFDRDRNVKYSSSIAKFMQDTVGILPEKCLIHFMNVDLDDISVNGTTMRILMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA26</accession>
    <name>A0A0N4UA26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7979</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN58006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA26"/>
    <dbReference type="STRING" id="318479.A0A0N4UA26"/>
    <dbReference type="WBParaSite" id="DME_0000397401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000397401-mRNA-1"/>
        <property type="gene ID" value="DME_0000397401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF14">
        <property type="entry name" value="GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041080017" evidence="3">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000397401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21849" checksum="E61D08AC726F1021" modified="2015-12-09" version="1">MFIANVLLQLLFVYSLIDCQIVNVTIFTESQCKYCTSLLHEQIWPFSLNRPGIMNLQIIPFGKGSCDFYPQKTFHCHCMHGPNECDLNRLQNCAIALFPRNYLGLLACAQGLNTLKEAFAVCLPPFKPETQKRLIECASTQEGELLNYYSMLYTHAADIRIWPTMFVNGRFFDRSYPVETEICRHTNWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAS6</accession>
    <name>A0A0N4UAS6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A_deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8155</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAS6"/>
    <dbReference type="STRING" id="318479.A0A0N4UAS6"/>
    <dbReference type="WBParaSite" id="DME_0000427201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000427201-mRNA-1"/>
        <property type="gene ID" value="DME_0000427201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000427201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32398" checksum="9E0FB68FB7BD1199" modified="2015-12-09" version="1">MQQREHLILATKEVIRDFSDENCIYLELRTTPKNTQWMDKREYVAAILEGFRISQLLYPKIVVRLILSVDRKQSIEDAKDTIELALEMSSVKDPLVIGVELSGDPRIDARKFLPLFSSANERGLSIIFHLAEMREHLDELYDCLLCKPSRIGHGTYIHTNTDKNGQNLCLEYVTKHRIPIEICLTSNSICNTNSYKESHLNYYLMNNHPFVLCTDDRGLMNCTLSGEYIIASETFGLSRQKLFNIAVESFKSSLVHKIGSKSLIDSIFAKFIQFAERENLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAZ8</accession>
    <name>A0A0N4UAZ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8239</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UAZ8"/>
    <dbReference type="WBParaSite" id="DME_0000435601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000435601-mRNA-1"/>
        <property type="gene ID" value="DME_0000435601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="10">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="10">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000435601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="65733" checksum="6DAE521F5F562EF0" modified="2015-12-09" version="1">MSSSIQNLNKPKDAFEQLEDEEGTRQGFCHIRIQQRTGRKTITTVQGIAPEYDLKKIVRYLKKTWFVPDEIFQSVEVAYYSVYGYGHLSWEWSSALRSVLHPAFIAAIFYLLRFLNLDTNYLVIILPRLLHSLIFALSDYYFYLFAKRILLTLSAANYSLFSLLSSWFVWYCASRTLSNSLETALTLIALNWYPVMSENADHLVVLREWPYVSIAVLTIIIRPTAVLLWIPLGLWRTLHSRSPIKLIFYTYIPAALPVILITCILDSFAYHKLTFSTWNFAKFNVFDGGCAHFGVHPWHWYLSQGLVSVITIHILPIVGGIYSSIKHRSIHFIYLLVPFFYIFVHSLLAHKEHRFILPIIPFLCIYSGHFLAHTLRKFALTKRILIFLMLLVNVPLAIYMGLFHQIGPNSALKFIREHSFVHFGSQKDFSVLYLMPCYSMPEYSHFHRFNVSVISLDCTPNLKNLSSYIDESDRFHLNPLLWVNTNKQLVVSSHYLVLYEKVFMNLEEFFTQNNFHEYNCNGTTVDHPEYGEVIQLTGDQRQHIKDFLCRVGIVKEENCKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB92</accession>
    <name>A0A0N4UB92_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8341</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB92"/>
    <dbReference type="STRING" id="318479.A0A0N4UB92"/>
    <dbReference type="WBParaSite" id="DME_0000445801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000445801-mRNA-1"/>
        <property type="gene ID" value="DME_0000445801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033512">
        <property type="entry name" value="TFG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335:SF7">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000445801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16832" checksum="085F565F1F1B8A4D" modified="2015-12-09" version="1">MVEDHTLGSTIVKARFGSDIRKVVVHHNDDLSYNDLVLMMQRIFKIKSSVNISLKYKDKEGDLITLADDHDLLLALKTEQSPISIFVLPEGCELPQIKKYFFVVNLIFLFLEKLNKSRINFIFIEFLFFEWRFYDYKYYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC64</accession>
    <name>A0A0N4UC64_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8726</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC64"/>
    <dbReference type="WBParaSite" id="DME_0000484301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000484301-mRNA-1"/>
        <property type="gene ID" value="DME_0000484301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057233">
        <property type="entry name" value="DUF7911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25492">
        <property type="entry name" value="DUF7911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000484301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38503" checksum="23D319C988B4F1F3" modified="2016-06-08" version="2">MRPSVAHTNFIEFDKETKRQMTLESFSVDDDLMLYIESNRVNDLYFASIYGVNLSESKSTTRLFDTNFVANINVLKKNTIKELLLRKLPKFDEVRIPKKYSLKGDNTSADEINPGIVQSSLVNTTLNYNSKGQLLSIVDEIETKLIKPTIKSKNDKNFVVQSNSDKDNVDDNSEIFNTYSLPKNINPTNPMDLMIKSNISGKIKQNIDDIDETDNHLLLHHDNSEIEEEEVERMGNLINDKTNEKVSEEPFWKSIESSEIIPSEDDDERRIDDGKIVFHLPQRIFDNKNYSKEIASINLSKPIIVKNEKASVASNAFISIYFMIMIISSIIIDYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC97</accession>
    <name>A0A0N4UC97_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ULD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS502</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC97"/>
    <dbReference type="STRING" id="318479.A0A0N4UC97"/>
    <dbReference type="WBParaSite" id="DME_0000488101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000488101-mRNA-1"/>
        <property type="gene ID" value="DME_0000488101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052721at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CMP" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000488101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9743" checksum="FF4D8B91DEAFB769" modified="2015-12-09" version="1">MSMFPVRVVVESVRPQHCLTCSREGHMLADSYAIVSGATLLSQLVDTVLGALGMPQLALHSKVDTKSYLKTIYTYMYSEASGRRDVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCN3</accession>
    <name>A0A0N4UCN3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8834</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCN3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCN3"/>
    <dbReference type="WBParaSite" id="DME_0000503501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000503501-mRNA-1"/>
        <property type="gene ID" value="DME_0000503501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12889">
        <property type="entry name" value="SPRY_PRY_TRIM67_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000178">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COS" evidence="4">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="219"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000503501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47159" checksum="6AD9209BF637178F" modified="2015-12-09" version="1">MAELSQTLTLLSEKAKHATEEIAKLKLLHEKINTNCSQFKEKLSAQIDALIEQLQEKKKIFLQHVENERNYKRRVFKEQISRCTGKLSRTTALIQFCIEILKEPDPVTYLQVSNALINRATTQEFLWHKEMQTKPEVDTEFVLNIDATHLRYAIECLDFAQLKVPNRPIIQTAECSAENNSVTVVWKAADKSCGTDGYILEIDSGNDDGLFKEVYCGPDTICTIDGLHFNTVYNALAWFQLCKSPSIVELHLSNESMSVSGSSMEYRCILGSIAFSRGVHYWEVTVDRQDGNGDIVVGVAQSSINLQTMLGKDLHGWSMYIDGERSWFLHNETHHSRIAGGIRTGSVIGILMDCDHGSLAFYLDDRRREFDGQRFAFRNMPRGLYYPAFSVNRNSMITVHTGLPPPINSSSDDSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCP3</accession>
    <name>A0A0N4UCP3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8845</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCP3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCP3"/>
    <dbReference type="WBParaSite" id="DME_0000504601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000504601-mRNA-1"/>
        <property type="gene ID" value="DME_0000504601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000504601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41314" checksum="0A0B834168A6112A" modified="2015-12-09" version="1">MQNWFSEYVDGCINHLINLTKPGKDKDEVGKIKEEINLVQLLEGCPREILDFAAHLKALTYSDEPNYDLLETILNNIIMKYNISFDEPYDWENGYEKIGGKARVNGEPIAKNRSHTTAIKDRLPEEKNKALDTQAPITMGEDDDEQTGAHGKWQVITHDKEQQDKPKYKRQEFMRPKYGPVNFDIIDAVNARLAAASRSSTDNLDANNANNTGKTKKNGDVEATFELPATLLKPLSNEQHINAQQCSTIGVCAIRQKNNNDRNSKGNRSVVIDLSNGKRNNKKLNIVPVDGSSYAQADDEGVVSSHLKAPTITSKWHASFDESCEDGEAIVEGIHGDKSENSISPKKPENRFAGVRPFRNIFFPCFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDX9</accession>
    <name>A0A0N4UDX9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9297</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UDX9"/>
    <dbReference type="WBParaSite" id="DME_0000555601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000555601-mRNA-1"/>
        <property type="gene ID" value="DME_0000555601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000555601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37329" checksum="4E51BEEDB572AA8B" modified="2015-12-09" version="1">MKLTIERQSRDYSILKIGVLIWLTFQNSIHTLLIRYARARDIPQMFISSVAVFLTEIFKAFVCIFIVIYEEGSFLKQQVFGNFFDTFKVCIPAMIYMIQNNLFYYAASHLEAATFMVASQLKIFTTAVFSVFMLRKTLTLIQWFSLGVLFIGVCLVQAYQTSSYRMATVQKPFLGFLAVVIACIFSGFAGVYFEKMLKDAAPISLWMRNIQMSLFSIPSSLIAVFVQDFFEISTKGFLYGFDSVVWTLVIWYCLGGLSVAACIKYANNISKNFATSFAILLSTIGSIYIFHFEPDTVFLLGVFLVIISIFLYSLPPKKLCGVKGYFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES0</accession>
    <name>A0A0N4UES0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9416</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES0"/>
    <dbReference type="STRING" id="318479.A0A0N4UES0"/>
    <dbReference type="WBParaSite" id="DME_0000589201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589201-mRNA-1"/>
        <property type="gene ID" value="DME_0000589201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49895" checksum="589CA01D16B12D2C" modified="2015-12-09" version="1">MKREVISVHVGQAGVQIGNACWELFCLEHGIQPDGRMPSDKQGQSDDSFSTFFSETGAGRHVPRAIMVDLEPTVVDEIRTGTYKQLFHPEQMVTGKEDAANNYARGHYTIGKEVIDLVLDRIRRLAENCTGLQGFLTFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVATAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDVERPSYTNLNRLISQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEALSVADITNACFEPANQMVKCDPRHGKYMAVCLLYRGDVVPKDVNASIATIKTKRAIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVPRAVCMLANTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSGEGEIEDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEU3</accession>
    <name>A0A0N4UEU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS857</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEU3"/>
    <dbReference type="WBParaSite" id="DME_0000591801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000591801-mRNA-1"/>
        <property type="gene ID" value="DME_0000591801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000591801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14616" checksum="F1EE22768335601E" modified="2015-12-09" version="1">MLPSYMTAQVCIAFISSAILYRGTIILLPNISCICVLLWYFWHFSVSSISLRQPHLILYQYDDFDATLDEMEAFPTAETCRFAYSAHWPDVVNSKCKRSVERDKHYPIVSHYNKVKQANLKCNQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEX0</accession>
    <name>A0A0N4UEX0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inositol-1(or 4)-monophosphatase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS888</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEX0"/>
    <dbReference type="STRING" id="318479.A0A0N4UEX0"/>
    <dbReference type="WBParaSite" id="DME_0000594901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000594901-mRNA-1"/>
        <property type="gene ID" value="DME_0000594901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN50915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000594901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42414" checksum="62850ACE521204A1" modified="2015-12-09" version="1">MWLPDIADVNEGYYLSSLISNYAILAVQAGGHAIIEIFEENSLEIVRKSKTDEGKDELLTRADLTSNFIILKMLERSLVSLYKVISEEKNGKISVDMLKYELNRYESYNKIQNLIDKLPPRKYNISDLEIWLDPLDATQEYTEGLVEYVTVMLCVVAEGSPVFGVIHRPFFNQTCNIFFNPSHAGSIKDLAKKAFGSDFEVEPAGGSGYKVLRLLNGTAQLYLHNTNIKKWDICAGDAILAAIGGSLMDLSGDRIDYGHNANIKIGKGLLAAWNIFRIIIIDNGTYHFENSFNQLNSTSRLFYKMVKSESMEEANSFEKHSSSFAFRPFGILEPFCIKTARKYIDSSIQLICEIATIRGDILKITQEYFRLKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF10</accession>
    <name>A0A0N4UF10_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF10"/>
    <dbReference type="WBParaSite" id="DME_0000599601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000599601-mRNA-1"/>
        <property type="gene ID" value="DME_0000599601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000599601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3860" checksum="0644A0BCBF3D866B" modified="2015-12-09" version="1">MVSTEELWQYSARCCLGTNKFCLFTASHMSYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFC6</accession>
    <name>A0A0N4UFC6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9425</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFC6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFC6"/>
    <dbReference type="WBParaSite" id="DME_0000612901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000612901-mRNA-1"/>
        <property type="gene ID" value="DME_0000612901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000612901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31945" checksum="98859C2D2FD72523" modified="2015-12-09" version="1">MTSDSNQIIQLNVGGISFSTMKETLLREPNSFFETLFVPEKLEKVSKFAILLANGSYFIDRDGYLFTFILDYLRNGRLIVPQNFDNLIRLRDEAEFYQLYNLKKYLDNYAVKKKSNDFSGILENGGYITLGYRGTFAFGRDGQSDVKFRKLQRILVCGKVTLCRDVFGDTLNDSRDPDRDEYERYTSRLYLKHQSLEKACDMLAEKGFKLVATCCSGANGLTPIGLTMCSNQNTINQQELMHQRNSSEYEEQRWAHYTEYIFYREPMYAGGILSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGC6</accession>
    <name>A0A0N4UGC6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9648</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGC6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGC6"/>
    <dbReference type="WBParaSite" id="DME_0000653701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000653701-mRNA-1"/>
        <property type="gene ID" value="DME_0000653701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF38">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000653701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30597" checksum="306AA2E46FD75BD1" modified="2015-12-09" version="1">MRSKIFAETTELALSFSGCGFLGIYHFGVLACLSTNGKVRSKLKRCGGSSAGSIAATILLLTPHKIQDALKKFYLLAEEVNGLPLGAFTPGFSLNDRLISLVDDHIPSDVSSLQDRLFISVTNYKSGENKILSRFNSRDYLVRCITASCFIPLYSMGSDMMAQPPVIDNEVYIDGGFSNNLPLFDDIPTVTVSPFSGGAVISPRDNNPYMPYVEWRVRFRNQEMNVNLRNIMRGAQALFPPSCQLLRNYYKQGFKDAFAFLIENDILERREGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGI9</accession>
    <name>A0A0N4UGI9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGI9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGI9"/>
    <dbReference type="WBParaSite" id="DME_0000661101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000661101-mRNA-1"/>
        <property type="gene ID" value="DME_0000661101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000661101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35626" checksum="6666827B0AC1500F" modified="2015-12-09" version="1">MKNINKEFELGKFVLTTTTTESSPTQDSPMPSSFPRIIKEITTHDSDNQKLSDRLNIVGCASPVFTLPLDNFKCSSTQTINKPNSNLDLQLYSNLRMRDLFRRNSHTLLILPEQKQISTISSSSGNSHMHLNMRNESGDPIIHAGHIMQLTKTKLSLNPSLTMHRKSTFTGWFNMKNNLMNEADRRCSQPLLSAGTDQDSTPSKRYGEGVMINDTRYQKHKASNENPPRILSKRVSWLSIKQYDDSDDILISGTKTSRRPSSTNISEHFSSRSNSRANIHYNSALQLDISSLADRGETPPSETISWSFAGDQIIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGR8</accession>
    <name>A0A0N4UGR8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9729</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGR8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGR8"/>
    <dbReference type="WBParaSite" id="DME_0000670301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000670301-mRNA-1"/>
        <property type="gene ID" value="DME_0000670301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF577">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000670301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15307" checksum="B60D924750F34B42" modified="2015-12-09" version="1">MFQDQLKGKDLVHALSDFPYYPPIDASTVSASLRPIGDSTVTDGAFKKIKAESSSSVFSSSLSNGPQVPASVRRRHRTTFTQEQLAELDAAFQKSHYPDIYVREELARITKLNEARIQVVLLYYISVELKKVNTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI50</accession>
    <name>A0A0N4UI50_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leptin receptor gene-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9934</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI50"/>
    <dbReference type="STRING" id="318479.A0A0N4UI50"/>
    <dbReference type="WBParaSite" id="DME_0000726601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000726601-mRNA-1"/>
        <property type="gene ID" value="DME_0000726601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000726601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10901" checksum="DD30AA0D983F902A" modified="2015-12-09" version="1">MFVITFYILSPMPILIAQRYQDDMGGTSACTELAYFATTGIVVSAFALPMVLAHAGVIRWMACAFANLGSVVMFVTVLCYFYLHREDESGSTWNQPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIJ0</accession>
    <name>A0A0N4UIJ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MacB_PCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10061</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIJ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIJ0"/>
    <dbReference type="WBParaSite" id="DME_0000742301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000742301-mRNA-1"/>
        <property type="gene ID" value="DME_0000742301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000742301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13170" checksum="E77445E23C58C7F4" modified="2015-12-09" version="1">MDEISTVLFRLAEGWPKKLHHRLLFLPLAAFPLANGTVVLISGDVFSTYDLKSNTPIAIGDKEKAFPNLPDGLVSGIPVISGRFDAYNLFDKQTVYEYSLKTMKILLAQPLKNFLLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIJ7</accession>
    <name>A0A0N4UIJ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">DME_LOCUS9999</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIJ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UIJ7"/>
    <dbReference type="WBParaSite" id="DME_0000743001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000743001-mRNA-1"/>
        <property type="gene ID" value="DME_0000743001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000743001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29192" checksum="178F279AC95A4F14" modified="2015-12-09" version="1">MSNDRSLREQLLECYEDIDSISKQVLVGHVEREQLIRKLEKAIEERNAIIEEIQTKLIISERALTEAVYQAGIKVKSIHQAESKKVNSEQIIRFANQISKSYSIAAPLHWQLGDPSRPFPTEIDFRLSSLAVPRITAPAATSAATLSLLRQPSNSQTILRGSSRGSPMVSYSASMQQRSWSPRGSFTQQSASPRGRGSRGSGLTSPRVGGPAFLQRRQSGNSPRISSPSSAYTIGNKSNINMPSIEPAIEQMSSDSSSSSSSDDGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKM2</accession>
    <name>A0A0N4UKM2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2326</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKM2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKM2"/>
    <dbReference type="WBParaSite" id="DME_0000829601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000829601-mRNA-1"/>
        <property type="gene ID" value="DME_0000829601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="300"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000829601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53725" checksum="0FCACCA5DB9AE77F" modified="2015-12-09" version="1">MGEIEAVQFILFEHAAGYCLFRVKEFEDTPLIVPQVEESFNNVQRFCSLVKLIAFSEFKNTDSALENCNAVAEGIIHDDLLNFLEENLPKKKKSVVTLGIHDQKLAAAISEKIHGVKCQFTGVVPEIIRGIRYHFFTLIKDLPHHSLQKAQLSLGHSYSRTKVKFDIHRVDNMVIQSIALLDQLDKDINLFVMRIREWYAYHFPELSKIVPEQNIYVKCAVAIMDRKSINEKTLENLGEILGENSESKVAEIVEAARTSIGMDISEIDLLNIDRFSNRIAALTDFRQNLNEYIKERMASCAPSLSALVGEQIGARLISHAGSLTNLAKFPASTVQIMGAEKALFRALKTRSNTPKFGLLFRSSYITRASKKSKGRISRFLANKCSVASRIDCFSEIPVPTFGEHLRQQVEDRLKYFETGEIPKKNADVMKEAISEAVIVQTKKKRARENGSMLIDDEYVKEKVKKKKKRSDFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKZ1</accession>
    <name>A0A0N4UKZ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10378</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKZ1"/>
    <dbReference type="WBParaSite" id="DME_0000843401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000843401-mRNA-1"/>
        <property type="gene ID" value="DME_0000843401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858966at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000843401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18289" checksum="DA49206E2B0D2F00" modified="2015-12-09" version="1">MGGSSSTPKIEPLLEHHQPYPDMNVIFKGIPKMIQVADDMHRMTNYIMDLRNMTFALICISAIGLFVFLILKVKQSRNNNARRKLEIGRRIESLDERSFPRHTHYGTYQQNYGDWHDRGKPTVSVDIEKLQMNNGNNNEKEASNPTNSKNLPNGQPHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM29</accession>
    <name>A0A0N4UM29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2728</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM29"/>
    <dbReference type="WBParaSite" id="DME_0000888201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000888201-mRNA-1"/>
        <property type="gene ID" value="DME_0000888201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800536at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000888201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18790" checksum="908FA4520602C24D" modified="2015-12-09" version="1">MDTVLKEDRDAALIVGTLGIFGIILNGLSIYTVLKTTNLRNAFGYSTISHAIGGMGVLLIFSIWVAPILFGLVLATSFIADCCRNPERLPHFMSNARLSYTIGQLCIWFYYASIYTHCLITINRYMAISKPFSYNKYFKERITLLWIALVWIISFLQSCAYQFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM96</accession>
    <name>A0A0N4UM96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2789</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM96"/>
    <dbReference type="WBParaSite" id="DME_0000896001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000896001-mRNA-1"/>
        <property type="gene ID" value="DME_0000896001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000896001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9891" checksum="36B699179264A550" modified="2015-12-09" version="1">MGKHAREKTMLQKRERKREKNDEWRELKREKGKIGFRATDSKWSLVNSVPEDARAAGRHLIYSSTFYNSTDLERQNGNNEPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMC4</accession>
    <name>A0A0N4UMC4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2794</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMC4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMC4"/>
    <dbReference type="WBParaSite" id="DME_0000899101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000899101-mRNA-1"/>
        <property type="gene ID" value="DME_0000899101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000899101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14792" checksum="1DEE76AB46726C47" modified="2015-12-09" version="1">MAIDWKQWPLLYPYFQRISQKRKGGQIRFTNEQTDTLEKKFSNHKYLSSNERKKLAKNLQLSERQVKTWFQNRRAKWRRIRKDGDDDDIFQLSPSSAQYHYEKFSQQYQKIYRSNFGFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMH6</accession>
    <name>A0A0N4UMH6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10574</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001226">
        <property type="protein sequence ID" value="VDN60601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMH6"/>
    <dbReference type="STRING" id="318479.A0A0N4UMH6"/>
    <dbReference type="WBParaSite" id="DME_0000905301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000905301-mRNA-1"/>
        <property type="gene ID" value="DME_0000905301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000905301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10505" checksum="3CDD05DD7F5254A9" modified="2015-12-09" version="1">MSTFQDCTIEEICDELPSQQPRFILISFEYNHTDGRVSLPLCFVFYTPDDLQMLYAGSRNHFVSECELTKNFEIRDAEELTQELLNSKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNI4</accession>
    <name>A0A0N4UNI4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3166</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000110">
        <property type="protein sequence ID" value="VDN53193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNI4"/>
    <dbReference type="STRING" id="318479.A0A0N4UNI4"/>
    <dbReference type="WBParaSite" id="DME_0000946601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000946601-mRNA-1"/>
        <property type="gene ID" value="DME_0000946601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000946601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16493" checksum="90B5477140A183BB" modified="2015-12-09" version="1">MPMHAVAILRGTNVDGEIRFMQENEGCPTMIEGHISGLSQGQHGFHIHQYGDSRKGCDSAGPHFNPFGKTHGGPQDEVRHVGDLGNIVADANGVANIKMSDHLIQLHGVNSVIGRAMVVHAGIDDLGKGTGDKLEESKKTGNAGARVACGVIALAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNJ9</accession>
    <name>A0A0N4UNJ9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3159</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UNJ9"/>
    <dbReference type="WBParaSite" id="DME_0000948201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000948201-mRNA-1"/>
        <property type="gene ID" value="DME_0000948201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000948201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42172" checksum="9A1A4C6AB2ADA064" modified="2015-12-09" version="1">MILLDNVQYSEEVEFHQRLVPTFWWNYELQDIPLPVFRAIIKKEFIKNAHLTDIRIIDRKVSECKQDMVNIRNSFYNADHKFFIDYKRNYTCRIESIALMLSSKKIFHVITSNFRFLSNKIAINSFLFDIRYKSSDAEEISYFDNLSMHWADESGPFRALHAFNRIRIPWLVGTIGDRSAVSYNSLHDLKIVDIGCGGGLLSIPLARLGASVSGIDGSVKAISVANQAASKILKHQSISGKLSFSCSTAEDFAEKHAEEFDAVLASEILEHVNNIQSLIHSCVRLAKRGAHIFFTTINKTTLSQILAVWLAEDVLHVVPSGAHIWSKFVDPTDLRALLHSNNCEIRLINGTAYNPFTNSWSWTRCTHLGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNP9</accession>
    <name>A0A0N4UNP9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10692</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCMBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001236">
        <property type="protein sequence ID" value="VDN60719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNP9"/>
    <dbReference type="STRING" id="318479.A0A0N4UNP9"/>
    <dbReference type="WBParaSite" id="DME_0000954501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000954501-mRNA-1"/>
        <property type="gene ID" value="DME_0000954501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000954501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45836" checksum="6CE4AC5C909F1B08" modified="2015-12-09" version="1">MIYWFEKHKADVESIEGSTATQWNFRSFCDFGDADITNKGRSIVAKFIHKSANNLLPNYIYDLYGIMDLSGVSTEADDNNRCTLQVLSFYEVTYPEMTHLWPEVSTLEQIVRGIDIMRQIFKSFFRDAVVTEYLLCHLISSTYARKDGYPICSMSMNLCNIENSSNVIHLLQLFCAKVNHILITNESLSEHLLQPRINDDCQLMQNSLQLTNGTNVVFDETKFSGEVPKDVNTILACKNLAAIKLLVSAQKVEYIYDYYELEFECDFNVLFLSKAPSLLIELPFIVPAPSNFSGDSEIIKKVNLTDNKILDLCRKAIFFCRNKVRTIGIRENCKSKITETFIRKRHHNRNTVVEELHWLLTLSKLLAALYGKNEVDIECWEKAQTMELYRIDLLKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNX5</accession>
    <name>A0A0N4UNX5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3287</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000120">
        <property type="protein sequence ID" value="VDN53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNX5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNX5"/>
    <dbReference type="WBParaSite" id="DME_0000963701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000963701-mRNA-1"/>
        <property type="gene ID" value="DME_0000963701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="257"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000963701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75900" checksum="089356608E561DD7" modified="2015-12-09" version="1">MTESDNEANFAKFILAKNRRQRKSGGWQVLGLDYGIFKGIERKGYRQPTPIQRKTIPLIIDGKDVVAMSRTGSGKTAAFVVPMLQKLKAHDTKGIRAVIIEPIRELAIQTHKVVRELARFTDLKCACLVGGDLIEEQFATIHAKPDILIATPGRLLHVVVEMDLRLFSVQYIVFDEADRLFEMGFSEQLQEVLERLSFNRQTLLFSATLPKMLVDFAKAGLSNPSLVRLDVDEKLSDKLSMIFISCRADDKTAALLYLLRFIISHDEQTIVFCATMKHVEYLAAIIKEAGMICVFLYSQLDAVARKINMQKFRNKECKILVVTDVAARGVDIPILDTVINFDFPPKAKLFVHRVGRVARMERQGKAISLFSADELAYVADLFLFLGRPLKFATLDSVHSEKEAIIGAFPDEFIDVEADFLHGIHETSIELEPLKLDPGIFKEFINATKKYKATRQQPSAESVRRTKKELREDFVSAATHPIFKTELQNGNERRSLLLELNNFKTFQAYVPSDFASERALAVDRGFDAAIKASAIDINADDDTGMYNQPKRKIWDRKKKRFVGPAGDMEKKKVRTEDGTWLHASYKSGRYEKWKQKQKLRYWETNDNNEEIPRCTNRINLPYRRHSELKNAEQILKERRRKQKIKEYQVYRRKENLKKSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP23</accession>
    <name>A0A0N4UP23_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10736</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001241">
        <property type="protein sequence ID" value="VDN60763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP23"/>
    <dbReference type="STRING" id="318479.A0A0N4UP23"/>
    <dbReference type="WBParaSite" id="DME_0000969101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000969101-mRNA-1"/>
        <property type="gene ID" value="DME_0000969101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000004">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232872" evidence="13">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000969101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57063" checksum="DE3077D0272348B2" modified="2015-12-09" version="1">MDHNTSGTMASLAAWLPFARAAAIGWVPISRQPMPPAPVSIQARDLAIDHVSDEKLLINISGRRFETWRNTLEKFPETLLGSNEKEFFYDEDSCEYFFDRDPDIFRHILTFYRTGKLHYPKQECLVAYEEELSFFGIMPDLISDCCYEDYKDKKRENQERLMEERLESADKKKKNLSFQEKMWAAFENPHTSSVALVFYYVTGFFIAVSVLCNIIETVPCKYVISGSNISCGDLYEKQFFVLDTACVVIFTVEYMARLFAAPDRCKFLRSIMSVIDVVAILPYYIGLGLTNNKDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATIMYYAEKKVFDTKFTSIPAAFWYTIVTMTTLGYGDMVPATIMGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRIVKSASGQAMYAKKKAHEARMRAFEEGLLSSDDLKEEDIFEIQHQHLLQCLEKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP41</accession>
    <name>A0A0N4UP41_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000124">
        <property type="protein sequence ID" value="VDN53352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP41"/>
    <dbReference type="WBParaSite" id="DME_0000970901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000970901-mRNA-1"/>
        <property type="gene ID" value="DME_0000970901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874082at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149">
        <property type="entry name" value="PROTEIN CBG11905-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000970901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13278" checksum="D95FF3F33594A8DE" modified="2015-12-09" version="1">MVRRFDKARAIIDSDVNKFMEFLWCPSKLIGTMCPENSLTYYYSCCGELRNKCCYNTRTWVLVASIAVPFIILIAIIIVLIRKFCVKRNDEYIPGQRQMSEQPQKNYLIGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQX0</accession>
    <name>A0A0N4UQX0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000210">
        <property type="protein sequence ID" value="VDN53917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQX0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQX0"/>
    <dbReference type="WBParaSite" id="DME_0001043201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001043201-mRNA-1"/>
        <property type="gene ID" value="DME_0001043201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001043201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29391" checksum="680E04AE96852D9A" modified="2015-12-09" version="1">MEECQKKELILYRAACAYYKKDFHRSSSEFEKLANITSCKNDHSSFSLTDSVIRSLLKADFVDHKNVLKMLEHSLSSSVCTYGGQLQYWSLYLQVYQKVKLFDKTHFRINVLLCAVVGLPEHWIALAEFGSEQSSFYWGCYCRALYLLQLQTMNCQGFMREISEKKLSEIQKKFSRSTCESFIVKECMKRMKENNFNNESTSLIDPKMKCLYKDDKEQERIINDFVERYSWLFENDSHLLDMLKFDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR09</accession>
    <name>A0A0N4UR09_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3924</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000220">
        <property type="protein sequence ID" value="VDN53951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR09"/>
    <dbReference type="STRING" id="318479.A0A0N4UR09"/>
    <dbReference type="WBParaSite" id="DME_0001047501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047501-mRNA-1"/>
        <property type="gene ID" value="DME_0001047501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20935" checksum="DB3011DC4E78AE81" modified="2015-12-09" version="1">MISEIMANGANQQQIEAEVRICCVIQVRMWPIENKVPLSTSGLLDIIKMARSWKKRAPDKPETKPTIVMSQQIFHLLHFSNGVNRCGIFVAANICIDQMDLDHEVDVFHAVKLIRINRPQLVDKDEYKYLYDVMLHWYMTNPEYRIFDKEENPKDVKMRNSIRRSTSVLNKTLTGNSTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR15</accession>
    <name>A0A0N4UR15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3936</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000223">
        <property type="protein sequence ID" value="VDN53963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR15"/>
    <dbReference type="STRING" id="318479.A0A0N4UR15"/>
    <dbReference type="WBParaSite" id="DME_0001048201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001048201-mRNA-1"/>
        <property type="gene ID" value="DME_0001048201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="222"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001048201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44452" checksum="4C5A5EFD217C9B72" modified="2015-12-09" version="1">MDDSGRDQVIVSINDYRSNVAKSLGKNIYKVEYDCELEENAAYSSHNCHFTEGPFYNLNGKASQTTAAVKPKVARRYQTSGKEPAIIMKEATALWWAEATPSKSNIFSVADKATKSNFTQMIWGKSTKVGCSIKQTCNEDNRLHSPFYVDYVVCLFKEGGNKVGEPIYDIGNGCNSDNDCTAFSNSRCDRSTSLCELQKSEMEKLFDPYSVPQCSNKKISEGDRRRFRKIHNDYREVLANAGGLGNSATDFYQLNYDCDLENSAQQVANQCEAGTIPKDRGQNSELTSAQSNADAIKAALSKWWNEGHNVPTSLAQRNVYSHEWGAYSRYTQMAWGKTTKVGCGINDCGQQKLVVCHYKERGNKIGEDVYETGLGCSSDSECTQIPNSKCNTDRKLCVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR20</accession>
    <name>A0A0N4UR20_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3941</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000226">
        <property type="protein sequence ID" value="VDN53968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR20"/>
    <dbReference type="STRING" id="318479.A0A0N4UR20"/>
    <dbReference type="WBParaSite" id="DME_0001048701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001048701-mRNA-1"/>
        <property type="gene ID" value="DME_0001048701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001048701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16188" checksum="26884864D815AB52" modified="2015-12-09" version="1">MAPKNIAANEVNDELKNDINNLKTSSLNSNFVLPNISTEQILQTTNEYFEKKEKEPCLVGINISEKSTDDETATADRLLAYEEFNEERTIPRQTVAKRMLLAISESHSEEICCQKSLNSGTQATSPMVCNDNFSIPTFSHQSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URJ3</accession>
    <name>A0A0N4URJ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTCK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4087</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000281">
        <property type="protein sequence ID" value="VDN54114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URJ3"/>
    <dbReference type="WBParaSite" id="DME_0001067501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001067501-mRNA-1"/>
        <property type="gene ID" value="DME_0001067501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001067501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31198" checksum="776A2E7BE8C46D13" modified="2015-12-09" version="1">MTLQESLPKVPTSKACSGRICALDEIITDILCSLTDQKCGPNMAFKTIVGPLYMKVGISSYKICIQQCICDSNEYTKMGGQCIKKSSVAMRNETEFGREILPKHCAGRVCALDEEIFNVPCSLTGKICGTNMIFTKIGKLLKKNGTEVCFQKCTCMSEEYVKANGQCILSTKGNETATPTSTQRSATESKLQPTMRKFSKTRSSKNCVGRTCERIRDLFCMLTDLKCGDNMVYKTIKQLIYNDGSPEICIQQCKCISEEYTKEGGRCIMRSTKKNPAQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URQ2</accession>
    <name>A0A0N4URQ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4137</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000320">
        <property type="protein sequence ID" value="VDN54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URQ2"/>
    <dbReference type="STRING" id="318479.A0A0N4URQ2"/>
    <dbReference type="WBParaSite" id="DME_0001073401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001073401-mRNA-1"/>
        <property type="gene ID" value="DME_0001073401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001073401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16363" checksum="0CD4DFD6189E5A1F" modified="2015-12-09" version="1">MAEDVDVYILDRYELQKRLGKGAYGIVWKAVDRKNKEIIALKKIFDAFRNQTDAQRTFREIMFLQEFGRHPNIIKLYDIIKADNNRDIYLVFEYMEADLHNVIKKLTILKDIHKQYIMCQLFRAIRYLHSGNVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URS4</accession>
    <name>A0A0N4URS4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4159</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000343">
        <property type="protein sequence ID" value="VDN54186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URS4"/>
    <dbReference type="STRING" id="318479.A0A0N4URS4"/>
    <dbReference type="WBParaSite" id="DME_0001075601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001075601-mRNA-1"/>
        <property type="gene ID" value="DME_0001075601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001075601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17992" checksum="F0D9B41BBF6F7469" modified="2015-12-09" version="1">MINDYNDSHEAFVFFQQNVEVDPRAIEAYKAMILQKDYAYLIFQISDNKVIIQEKGDQKASYSAFLTKFRQYVEGKKECRYGLATIKGHKDGELRAELVLISYCVDDAPIRMRMLYSAAFGHLKVAFKEIRNIIITSNGSELTEKNVKRTFHFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URZ9</accession>
    <name>A0A0N4URZ9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4229</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000437">
        <property type="protein sequence ID" value="VDN54256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URZ9"/>
    <dbReference type="STRING" id="318479.A0A0N4URZ9"/>
    <dbReference type="WBParaSite" id="DME_0001083101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001083101-mRNA-1"/>
        <property type="gene ID" value="DME_0001083101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="8">
        <location>
            <begin position="263"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001083101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43761" checksum="78ACD20F57B594A4" modified="2015-12-09" version="1">MVKQAAHIPIINSKFYDGVPGKFTPMPYGPLDTRLEYGLLSQDRLLSDGGKDKTSNLNFFFQGTCQKNIDCATCKSNLVDCVGHFGYMDLALPVFHVGFFNSVMHVLQCICKSCSGLLVSDEIREKFLNELRKTSLDYLKRKALHKRIVASCKKNTTCPHCGSKNGVVKKATGAVLKIAHSDTITENRLPEFFAAVEENKELHSLLPRIKFDVLDAVHVEDIFSKIRMEVILFFILKMLIFVIGKIKDISLLMAHDSEMKHPLDLLLTRLPVPPSCIRPSVISEVKSGSTEDDITVMLSEIMLANKILSRYVENGMPTKTINESWDQLQVQIALYMNSEISGLPMELQPKKNMQGFAQRLKGKQGRFRGHLSGKRVDFSGRTVIFFNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USC0</accession>
    <name>A0A0N4USC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4342</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000862">
        <property type="protein sequence ID" value="VDN54369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USC0"/>
    <dbReference type="WBParaSite" id="DME_0001095201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001095201-mRNA-1"/>
        <property type="gene ID" value="DME_0001095201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001095201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="46" mass="4677" checksum="61647A840F587B84" modified="2015-12-09" version="1">MGLRTNFYGLKCVAIVAPASGGTYGNIAVQAGESMCAQRLGSTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2P9</accession>
    <name>A0A158Q2P9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4947</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2P9"/>
    <dbReference type="STRING" id="318479.A0A158Q2P9"/>
    <dbReference type="WBParaSite" id="DME_0000058701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000058701-mRNA-1"/>
        <property type="gene ID" value="DME_0000058701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000293">
        <property type="entry name" value="SRSF protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="77"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000058701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59610" checksum="58802AB77AD80D2E" modified="2016-06-08" version="1">HQLHHAPSGGKLVPSDPNFDENYVGPPSGDSESGECEEINEEEEVLGSDDEEQEDPKDYRRGGYHPVTIGDVFNGRYHALRKMGWGHFSTVWLCWDTVMMRFVAMKIVKSAGHYTEAALDEIKLLMSVRNADENDEFRERVVQLLDEFSVTGPNGTHICMVFEVLGCNLLKLIIRTDYQGLPLELVRVITRQVLEGLQYLHEKCNIIHTDIKPENVLITMDHEDIKKMAAEALYAEKFGIQMSGSAVSTVPAHVLKKYEESMSKNRRKKLKKKRKKQRELLELQLSQVEGLSVDISTANGPMKSTSINGPKHHHFTEDIQTRQYRSLEVLIGAGYGPPADIWSTACMAFELATGDYLFEPHSGDTYSRDEDHLAHIIELLGSISPRVYKKGEHWRNFFDKSGRLLHITQLKPWPLVEVLMQKYEWPLEHAAQFASFLIPMLAFDQEERATARQCLQHDWLKPFGGKNPRIRKNLSLVNRDYVGYNSTIRIENDSDDKIKEIGNSDAIQLSSLSIESQIDDGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3L5</accession>
    <name>A0A158Q3L5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7016</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3L5"/>
    <dbReference type="WBParaSite" id="DME_0000265601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000265601-mRNA-1"/>
        <property type="gene ID" value="DME_0000265601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000265601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17137" checksum="C1C9DCD111A76FBE" modified="2016-06-08" version="1">MEADLLENADGIKEEVIANNSVPSGGELPDTLRNSKSGMYFEFEKLLNGFDNYYNESSDSEEEIGANEDDSFNFEMCRIRRTKRYSSCISDVVNKNSCTDCVTKNEIHKENETSGQSLMDIDDIICAIREGFNESPPLANDDEFDDFDALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Z5</accession>
    <name>A0A158Q3Z5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7662</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Z5"/>
    <dbReference type="WBParaSite" id="DME_0000365701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000365701-mRNA-1"/>
        <property type="gene ID" value="DME_0000365701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8065890at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000365701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17176" checksum="D34BEFC99EEF6FE1" modified="2016-06-08" version="1">MVKQKINKKNDFIIHRVTIRSTGIVNPNHGKHLWNLWKGKYVWDQSINDADEEQWKTLISKWPKQELEQANSCWNRLWCHEKYATVWSDAKCALFWVRTIKITSAILTKLSKSDTATRGISPTKLRYSKLWWNGRYWLDKDPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q418</accession>
    <name>A0A158Q418_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7804</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q418"/>
    <dbReference type="STRING" id="318479.A0A158Q418"/>
    <dbReference type="WBParaSite" id="DME_0000379901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000379901-mRNA-1"/>
        <property type="gene ID" value="DME_0000379901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="2">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000379901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24921" checksum="F77A6D7578CB7657" modified="2016-06-08" version="1">MYELSKEIFMVNGSASNFPNNLDIHYDESKKLTYACIVHKQQVYDCPLQFTRGITSVNNLILVGTHIGDILVFEYANENSISSKKVIQEHHCAIVDIIKHESEDVICSCDVVGNIVIWTKSMKNIQSATSTGFDINCFNMLKNYLVIGTMIGEILLYSLNGAQLLIKINAHCRQINAISTASDNNYILTVAEDSIVHVWSLLMDTDPILTKSMKLQERFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q451</accession>
    <name>A0A158Q451_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS385</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q451"/>
    <dbReference type="STRING" id="318479.A0A158Q451"/>
    <dbReference type="WBParaSite" id="DME_0000402101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000402101-mRNA-1"/>
        <property type="gene ID" value="DME_0000402101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5840142at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="524"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000402101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134112" checksum="3D733FFB631A0259" modified="2016-06-08" version="1">MSTLVDLFREAANGKHRDNIVVCDSERELSLKELDSLSEQIAKYFVQKFHAKKGNGIAIYMDKCANYVLAYVAALKAGMFLFSHILMLERCAYIPIDVSYPESLLRDILKEVSPAVVCTTEKYLKNLPEGIPIYTFTPINSSYENIQLPKVEPHDRAYIVYSSGTTGKPKGIICPHRGAVVSYQFRFSTYPYGDDEREACNVFFVWEMFRPILKGIPMYIIPDSVIYDPQSLCEYLSEKLITRMLFTPSLLETILDTQSDHFVKKSFRSFRTIILCGEVVTMKLLDRIKKLLRNVQILNLYSVSECHDVSYADLTNYTVALEERKYVPVGTLIPGVKVAVFNGNLEMVPNGINGEIFVAGPTLAIGYVNRPELDRIRFMTVPEQFQPELGERMYRTGDWGYLLPNSGLEICGRCDSLVKIRGYSVEIKAIESNLNELSYIASCAVISIGAEGDDKKLAAYVVLKETVSRKKIRADLKQRLPFYMIPSFFVFLDKIPVLPSSSKVDKKGLPPINPEADVIEADSLPQTPTEIRLAKLWAEILSRSDIDIQESFFDLGGHSLMASRLLGKIQREFGVEFAMNDLFAMPTVSAMARCIDDSELKHRGQKRNLAKAVEIHDFKYQIMDLHLRAFWRSVGWTNRYYNGLILLTGVTDVVLLRLGLSEEDYTFLSHDVDTVIHAAAYVNLIYPYEVRSNTVFKALQGVNVLGTRNLLDFCHRNKIKILHYLSTDAVIPEDLDYADEDIDSNSCDIDDRLCGGYAETKWVAEKLVQRAESRGLPTIIYRLGNQAASMLTGKWNSLDFIYLMLISTIRLKVSPKIDWMMEMTPVDFSSSFIARMATERFKSGIGKIFHLINSNALSWNQVIEWMRKFGIAIEIVSFNNWIQLVSDDPAPESQQLKKLIDGMIRDETYFAASTIYRRTNTDRELKEINCTYPIINETLFRYWLEILVDKKLIKTPGLSLDMEGKVCIITGASEGIGAAIATELALKGQLRVVLVARQTQKLEELAKKLKSKGCHASNILITKCDITSISDVENMVDCTLKTFGNIDVLVNCAGCMYYQLMKNGGKEEWDRQIDVNCRGTTYCIGTGFAGLAVYSGSKFYIEGMTQALRQEVLEYGIRITNIQPGDVATRLASRSIDQEARTKYDFSMAGHRILDTKDIASTVLFVISQQPHVAINEILIEPQAAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4B0</accession>
    <name>A0A158Q4B0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="37">Trifunctional enzyme subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="36">1.1.1.211</ecNumber>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="38">Monolysocardiolipin acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="39">TP-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="42" type="ORF">DME_LOCUS8340</name>
    </gene>
    <organism evidence="43 45">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="42 44" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:31180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:31188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:31160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31195"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:31196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31199"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
            <dbReference type="ChEBI" id="CHEBI:62614"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:31168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43676"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:43677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43672"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83581"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:43673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43680"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:43681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:16107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:20726"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:136757"/>
            <dbReference type="ChEBI" id="CHEBI:136758"/>
            <dbReference type="EC" id="1.1.1.211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:52657"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="35">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.211" evidence="36"/>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4B0"/>
    <dbReference type="STRING" id="318479.A0A158Q4B0"/>
    <dbReference type="WBParaSite" id="DME_0000445701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000445701-mRNA-1"/>
        <property type="gene ID" value="DME_0000445701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000011">
        <property type="entry name" value="Fatty acid oxidation complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000002">
        <property type="entry name" value="Trifunctional enzyme subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="41">
        <location>
            <begin position="295"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="40">
        <location>
            <begin position="475"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="40">
        <location>
            <begin position="596"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00052989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00062153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00066806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00068347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00077617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00083277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="EMBL" id="VDN58367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="WBParaSite" id="DME_0000445701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="684" mass="75918" checksum="B505DF3F25FCB42C" modified="2016-06-08" version="1">MKFHIFVILLNYNDFFIITFFNLPFQQENVLNKGLLNKMSDLIAHIESNSNIHSVVIMSGKTNSFIAGADINELFKLKSAEEVQKLSVEGQQKLMHIERSRKPFVAAIMGTCMGGGLEVALACHYRIAMNTPKTMLALPEVQLGLLPGAGGTQRLPKLISFQNALDMMLTGKTVPVPKAKKIGLIDQVVQPIGIGIKSVEENNLHYLKQVRIPKFEQFLNYLLFIMKLTLGNYPAPLQILNLVKMMAENRDKVFYNEESKIFGELSQTTQSSALIGLFQGSTECKKNKFVFFRKLSVIGAGLMGAGIASVSIDKGITTVLLDMHDEGLSRGMNQIYSHYDKLAKKKRITLLQQSNAIARLKPTTNYEDVKNSDVVIEAVFEDLSLKHKVIQQLESVIPSHCVIATNTSALPIEQIASVSSRPERIIGMHYFSPVEKMQLLEIITTKKTSKETLAIAANLGLTQKKLVVVVKDCPGFFVVRCLAPMLNEVMRLLQEGVSPTQIDKMTKSYGFPVGAATLADEVGLDVAEHVGTFLGKELGPRVAGGSVEMLTEMVSSGYKGRKSGKGYFVYRSDWIIKKYLLIPKAEVSSVEDQQLRVISRFINEAAICLEEGVISSPSDGDIASVFGIGFPPFWGGPFRFVDLFGAQRLVNEMQRFGNAYHPQQFQPANILLDFAKNNKKFYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q529</accession>
    <name>A0A158Q529_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS1225</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q529"/>
    <dbReference type="STRING" id="318479.A0A158Q529"/>
    <dbReference type="WBParaSite" id="DME_0000632801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000632801-mRNA-1"/>
        <property type="gene ID" value="DME_0000632801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000077">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000303">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="308"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN51252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000632801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50143" checksum="45E5E5208A1222AA" modified="2016-06-08" version="1">MESKEIVLVKFFAPWCGHCKRLAPDFEKAAAELITNEPPVELIKVDCTVEKKTCEKYGVSGYPSLKIFRNGQYSQDYNGGRTADAIIKYMKGQAGPSVVVLSSKKDFDKFTSSDDYVVVGYFDSESKLKDSYFKVADTERDRFSFGHVTDKSLFKDYSDDIVVYVPKKLHNKFDTNEIKYDGNYDTDKIKEFLTYDTVGLVGVRTIGNLFQFTKKPLVVVYWNIDFALNPKGSNYWRNRVAKVAQDYKRKVHFAISSKEEFSHEVQEYGLGDRSTSDKPIVAAQTKDGKFFMDTEFSVENLKNFVEDLVKGKLKPYLKSEPEPDTQGDVKVIVGRSFKKMVMESDQDILLEFYAPWCGHCKKLAPIYDELGKKLARENIMIAKMDATANDVPPPFEVQGLVRFIFLLFYYFRLNWADFYFANLISQDDEIHQFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q537</accession>
    <name>A0A158Q537_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS9521</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q537"/>
    <dbReference type="STRING" id="318479.A0A158Q537"/>
    <dbReference type="WBParaSite" id="DME_0000641001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000641001-mRNA-1"/>
        <property type="gene ID" value="DME_0000641001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033778624" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="317"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="14">
        <location>
            <begin position="657"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="15">
        <location>
            <begin position="809"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN59548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000641001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126558" checksum="350D0D816CE6754B" modified="2016-06-08" version="1">MFIELFSLLYLRLITEISITLSFNIDIHSPVFKYGLNGTYFGFAVAQHYNGIHPIILVGAPRAESGQPYTRQAGALFSCPINTIYFDKSKGWCKKEIVEYVDKNDLLKPVGYVHGKQLHYQGKNRQLLGSVVVSSAVPNGIAMVCAPLVRYHNTSAYTDGTCFVLESDLNQKEMLISCAQPGLPRTDRHNEYGSCMEGFSGYVDESMVITGLPGAKKWTGGVFSRYYPKDIFAMNLDRWTMGVEPKYHGVRSKFQGHDYLGFSVNHGRFGFWFEDDENSTIVSGATRYNQTGAVTFLPFRRSHPFGSPESHHLTLTDDSFMLLGTQLGSSFGYSIEVNDLNNDGFDDLLIGAPFEYMENTEQQYGGAVYIFFSSGKKRSKHENSKVFLEPIKIRGPDIYSQFGLSITSLGNIDDDVNKFNDFAVGAPYANGGEGAVYIYHGSKSPKDFKDQPAQVILASDIQIPVKSKLRSFGFSLSGGIDMDGNGYGDLLVGAFASDAVVLLRSRPVINIQAKLITDELKIDIDGDSSCYWEAQTCFSVTTELSVDSLNSRSTRLLDFSTNVFECMLEVVPLNVGIGSRARIVSSGDEKYTWNCGRNNKNSDWINAIKLRFSVRLRNDAKPTLPKNGEQLIDLNNFPVLNKFGSEDFASIHFNKKCGLDNICTCDLQLQSVLPGISKADDSTYMTQVGEKASIDISFVVSNFGERAYEAQLFIDYNSNELDVPVLSKKTGPVNIKSVGENYAVVSLGNPMEPRKQLKFELSFKLARGRTEGLGKPLEFRAHVNSTSEETDLSNNFWDAIVRVIKRAELELTGVSEPPIVRYGGEIRGESAMEFDEDIGVLVTHKYTVTNKGPWSVSNALIEIDWPYQVASVFPKGKWALYLLEIPTVQTMNTDNTKEIKQCSMALPTEWVNPLQLKLFLDAGVSFNYDDKLKELEAKYLAIRNHRSERSVESEETLRPSRELRIKTISVKEKSGEEVQIVRVSCAEYSAKCFTVTCSLDFLDVDATAVMEFRARLWNATFVEDYYDVTYVEISSSGRLLLDPEQGIEEDTSNNFAFASTHAYPDRPAIQEMAPIPWWLIAAAVVGGLFILFILILIFWKCGFFKRNRPSQPMLHQAEYQFRQEEWAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Q3</accession>
    <name>A0A158Q5Q3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2086</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Q3"/>
    <dbReference type="STRING" id="318479.A0A158Q5Q3"/>
    <dbReference type="WBParaSite" id="DME_0000796101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000796101-mRNA-1"/>
        <property type="gene ID" value="DME_0000796101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863505at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250217" evidence="2">
        <location>
            <begin position="19"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000796101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48229" checksum="03D048D8112BA44A" modified="2016-06-08" version="1">MRCFLLLILCICKAKTQIAPISSLLSGTLNGLNAAAGGGNGLGQLLGNIGNLYQLAQTALQLTGTGVGILNQASEGRWFEALLERTASNPFLNPFQYPPQIAGPNLNVPHGGSLLRNRPDIDSLGIEANLLGTEFPPPKPEDYDEESSSTIVENLIEFTTEQSRTKKKGVTLFPEEKIEKKNKKNGEKEFIKRNKNLSSAEDYDEIIKEIDEKESFNIDGNNEIIGKDEFIPTKSKFNEEEKAKLEILDRHLAKLSKLIEILEEKNLTNEKLNRIALSIKNEDGTYRNSRVPEKTFAAKPTVLRLNAIRLPISGIRNLDSQSNTVKIIPVDPAENMIIARHTKPNRPEGNHAIRTLHSGRQSTTVNFFRRKYPRRTVPTRNIPFRNTTPFYHNINQRPQRRSLSRTNIANVSQEKITVSFKDKNLANSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5U0</accession>
    <name>A0A158Q5U0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="13">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2307</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5U0"/>
    <dbReference type="STRING" id="318479.A0A158Q5U0"/>
    <dbReference type="WBParaSite" id="DME_0000827701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000827701-mRNA-1"/>
        <property type="gene ID" value="DME_0000827701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048179">
        <property type="term" value="C:activin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048185">
        <property type="term" value="F:activin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017002">
        <property type="term" value="F:activin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23617">
        <property type="entry name" value="TFP_LU_ECD_Daf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="293"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000827701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="723" mass="80261" checksum="CE9A441C9F79A5F2" modified="2016-06-08" version="1">MVIAGKQKVFVVLIQCYFLLLVITVGAVTTKTIRNAEGAVAAAAAAAAAAAAAAASVLDDDFADLSPSLKNVANAVKVELPAKPAFLERFGQEGVNYDLDNRSRPFILCEFIAPISCDPAKSICSGVKQCYLEGRKHERLGCMAVTDNQRQNGSFVKDCWPHSDSIHKCLSGHCTAERRSANQVDVFFCCCSTHNCNVNVFIPPQLSTAAPSTFAPISKDPGLFSSDTWAAIFILIAFVCTCLLLILCYWTYRELKNSHLFKGKAVDSYAISAISDVDTPLINCKKDEGWRNITSLEIVARGRFGQVYRGLLDDMPVAVKVFPNVDAASWILEQEIYTLSALRKNGNILRYIGSEVHGSTYWLITEFHDTGTLQDFLKTHMLSLCDSLKIISSMLKGLSFLHEEKMIDGEFKPCIVHRDFKSRNVLLKEDLTSVIGDFGLALKCENGQMPADENHGQVGTRRYMSPEVLEGATEFTAFAFRQIDVYAAALVIWEILSRTVLKEDDVVPEYKQPYQDEVGLQPSLHDLRRVVVALKIRPTVRQELIEHNIAGVLWKTVEDMWDMEPDGRITSGCAYERANTLYLSYSATLTGDSSENATITTSDPHSHVGSNCYSYASEELVNQQPALLIKDSALGLNGFNANMDIYSQSCIPPNMKFAPSTNNHQQSDIFHENQMRQLCFKQQQPQNQQQKFNNNINNIISQSCLAKSSSPSLQSEILQTVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q602</accession>
    <name>A0A158Q602_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10467</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q602"/>
    <dbReference type="STRING" id="318479.A0A158Q602"/>
    <dbReference type="WBParaSite" id="DME_0000873401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000873401-mRNA-1"/>
        <property type="gene ID" value="DME_0000873401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9898580at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="7">
        <location>
            <begin position="632"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="384"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000873401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="684" mass="78570" checksum="0CD7B37E0A3B7FB1" modified="2016-06-08" version="1">MLRGSDRISRSELLKQVGEQKQQLALYEKKLKDIIRAFKSLNAEKEALQTTIEALGIADAVNGSEVGETNESKTSIAVSEDRLEELKRSLLVLITENKRRETALQADKKALLELRAKLIRIEEDRERELIDHGSVLAEMQQRFAREKSTNEQIKKQFAELYKKLHEKDALPMQMENSLKELQSDLDKAKDDVEFWKKKAEKIPTIQMLESELQNIKKGSELEIQELKLKLSNASDTEKESRLQKLEERLKEITSSLGNLERTRIKNEQIIKDLRKKNAMLKKENEILSQSSVQKEVESLDLETLKQKTLHLIEMIRNRNGGVNFYETIGVKESSNDSKYEELKEEFELYKLKAQSVLRSRNISLGEDGLPSVSSLPKVDECSSCASAEIELHNLRSAVASLHEKLYGIEIDHANAKNDYEEKCTELQKTIVELQASQIKTVNCLRQQMQQKISEMEAEMQKQRVRTLDILAEKEKELEIAKNQRVVSNDPIDPPQRELVRKKPSLEFSESSNAIEKPATVFNSCASLAAYGRAASETESYSSVMDEHPLERLSEKKYSLANMTNTVEAKNIFYEQQLAIKEKEIIDLSSAIRMAEMTIRDLQQSSITKDLQHFEIIGKLKDEIRILEGKLNFHTSDAHMEYLRNVFIQLLHCESYSKRKHILKAIGTVLKLSIVEMRLIDKHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q608</accession>
    <name>A0A158Q608_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuroblastoma-amplified sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2664</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q608"/>
    <dbReference type="STRING" id="318479.A0A158Q608"/>
    <dbReference type="WBParaSite" id="DME_0000877301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000877301-mRNA-1"/>
        <property type="gene ID" value="DME_0000877301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19988at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000877301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="159845" checksum="2ACE65EC87457D3D" modified="2016-06-08" version="1">MRNKTDESKILREKITLKQWTETIRLASPKILFAYKEICAYLEALPLCKLAVSKDGLVATMSYDRELEIAQIEGETLVTRSIVKENILTSSEGYKEDFTMWEYHSEVLIAMSPTCRTFGIFTNILLWRFILPERYPEWCLLDWSDSGSLLISTRSNAIIDIFDAYGGYCYSIPMANSGDNFNVSTVISHVSTQAYAHDDSKWLDCLYILQYGGYFSSYKIGRLAGYFPLFKVNIGQDIATLFTIVPSLNLLIVANQYKVNPVEDSSLGCNSIGLNVYRIVDEEPFIVDVKTTRNEISFFDLFFNWLPFGNAQTGVILSMSLSHDWSLLACVSSTGRYLCFLGNSAEIAVLTKGGWLWSGELNVFEISHFDDDDEFECFSPSTKLISPRSGEMFALEAHYLSDSRIFMSENSRTWLAAKLRLTTLYDYFKAYVGVAVGQPLEDVEAPRECREIHFVLHDLRSITLKQMLHKMLLCGDFDGAHNLVNRCGIDESDFVYKEQWRYIGQNAKERDVENVLEKISDDAWVINECTSNISPNINLHKTLILLAKELSEKHKNGQFLLVLHCHRILAILDENSTDSANIYVHLRSLSLLDVAIYLAQVCQFKYLKRLICNNWNILYPHLFTILWMIPESVNPQKYEEFLPHKCSSWFTSGQFDNEYRDIIISEPRELSEECLLVQKKLNFETDIYDRKVFLQKYQISDALKLADVLEYLKDRCSALDVDSGLVHNVESFVHLSIERGFTELQSLLEAVEFYRDYIFFCGAVTMSFNHFNNCSSDFLLGTLSKHMTENHIYDNMERLLGMIDYLYQLGRCTALDEDLISFFGVFSKTSMRVLLKAQDLWKERITNHVKIECLRMFEKVGEILIIAAAQLQIEEKFIEALEIFSAHELFPTFDQLFASLSDSSLADKMLYRLIKSSKPSTKIMWFNLKKDILAVHSKLYSDQITEEEVIRNIALQMLDIENLSITRDFLDLVFNFDGTKKVSKCLPQSEAVNMIIEKSNYYWNIAEPKKGDKNLEMARQILSVAPKECSPLFDQQLRILDALDLAIELGCKIMPVKFRFLDREDLFGQIVNIKSNYKKVKECAALAKLLHIHAPVARALELCAAQALLIRDERILRKYCEQLLKNPKNVTDIHKLCIDVARSGMLEDMEESLFGYALLTCNDDSLAETLLNIEEIKLKQMATSSTELKPVSLYNELVLDPMYCSIDHYYPRTAISFDNSEETLMEETAFSFDTKAISNDFLINLTQRFARISSSVAICVSLILPDNSDWTYNNFLKQYSNALRLARNDLPSKMLELVPPQLLIASYSSRNVLSASQMRNGACLENVTENVTFPGCDRERFFEDAEYRADTLNGLAMSVDEEILSDCWNVAANFGMNVYNICLSTLEYVLTDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6F5</accession>
    <name>A0A158Q6F5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3508</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="UYYG01000142">
        <property type="protein sequence ID" value="VDN53535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6F5"/>
    <dbReference type="STRING" id="318479.A0A158Q6F5"/>
    <dbReference type="WBParaSite" id="DME_0000995701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995701-mRNA-1"/>
        <property type="gene ID" value="DME_0000995701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16200">
        <property type="entry name" value="EFh_PI-PLCbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000047">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="7">
        <location>
            <begin position="328"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="66285" checksum="778BE1A1C54CC1F1" modified="2016-06-08" version="1">MAKEYQFNWKPNIPPALIDGTFFDRYDDESTCLDLNAHVCIDDYGFFLYWSCEGKDAVVIDLVQLWEARVAGLPKDGRILFELEQRGPRETLEERTVWITYGLDLVAVNSFYIVAQDIEIAKLWRNGINEILKNCKMKHISYMTSLMKNWRYLCLSLNDRRKIAIKNIVKMFISGKTEKMVQKCLSDLGLSGDKVGEIHIQFKNSTKCFQEREELDVELFTFEKYLRLYYKICPRTDVQELFVRLSGQKEYLTMERLINFLNEEQRDPRLNEILFPFFDQKRTQQLINKYETDENYVNNGKMSGDAFLRFLMSNENAPVFLDRIELYQDMDQPLCHYYINSSHNTYLTGRQYGGKSSTEIYRQVLLSGCRCIELDCWDGTGDNKGEPIITHGKAMCTDVFFKDVLYQIKDTAFARSEFPVILSFENHCSRPNQHKMAKYCMEIFGDMLLSKPFDDYPLEPNIPLPSPNRLRKKILIKNKRLKSDIEKLQMDQFLREGKLDEEDEAIESPEAVVGEDIDAPREDIQIKEIDEAHPEFKSNFISKLKPLSFTKKPQVFLNIFQILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6G5</accession>
    <name>A0A158Q6G5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3554</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000149">
        <property type="protein sequence ID" value="VDN53581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6G5"/>
    <dbReference type="STRING" id="318479.A0A158Q6G5"/>
    <dbReference type="WBParaSite" id="DME_0001001901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001001901-mRNA-1"/>
        <property type="gene ID" value="DME_0001001901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF16">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001001901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40420" checksum="CEF4B5B0674EAB34" modified="2016-06-08" version="1">MIMSSTEGCEIGSVPLPDISGLMSTITSFSQKYGELHPYIALFLCITGIILNLITVIVLSRRTMLSPVNILLCSIAICDGIVMMSYLIFVAHFLIKAASRCESSDYNYHWAVFTLFHAHASVIFHSTSIWLTVSLAQIRVLMIRRVTVTNGSIITIYSTILLSFITCIVMTFVNVPNFLTFQIVETPSVDFLPCLIPQDEGSYNSSGIENSLINASTLSNADRYIYVVLATGNDCMKLKLAFWSNGMLCKVVPCFLLTISIIILLKIIAEVAHRRKILAQVLKKKMPKDHMTPMLVAVLSIFLIAELPQGIMLVLTGIYSKDSFHQKIYLPLGDFMDLLSLINSAVNFLIYCVMSKKFRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6L9</accession>
    <name>A0A158Q6L9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4393 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3892</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000210">
        <property type="protein sequence ID" value="VDN53919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6L9"/>
    <dbReference type="STRING" id="318479.A0A158Q6L9"/>
    <dbReference type="WBParaSite" id="DME_0001043401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001043401-mRNA-1"/>
        <property type="gene ID" value="DME_0001043401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843658at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001043401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26336" checksum="9D951CE4F5678E2D" modified="2016-06-08" version="1">MSENELVIASDDSVWGRITLLVRSLMGEAYTPKHRAQFYEILLTKSLDNRGFEENELKYMIDKKIAELNLEDPEKAKRFVFLLDRLKKLYEDGDKIIGFLFAMSSEKREKCVEHVSENKNHTSKSSIKRNPLTDSYFNAVVHFNPIAEVQVNSNEIITVPLYDTDIFFLNCKSKGYFFQYEFAFFDDAGESAVRNLILGFAGRLDPRITDPELRQLYIPFREFLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PBQ1</accession>
    <name>A0A3P7PBQ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PBQ1"/>
    <dbReference type="STRING" id="318479.A0A3P7PBQ1"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22128" checksum="8E7035AFB70329A3" modified="2019-02-13" version="1">MAIIGVSNNSGRNGVAIVMSDKAHSALIEWKQVSDRMTYARFKGSAISRIIMPLTSAIGEYGIGKLCTNGERLLRYAEKYELFVTNTCFRYRRKRLVTWNSPDNQHFNQIDYILISSSWKSSVLDSHSYRGAEMSNLHGSDHVMVPVKIRIKLTTHRKQHPPRFLNYLKKFGESERISNRIIQASQWYKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PIP9</accession>
    <name>A0A3P7PIP9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PIP9"/>
    <dbReference type="STRING" id="318479.A0A3P7PIP9"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20809">
        <property type="entry name" value="C1_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="307"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="6">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="91975" checksum="A5C8FBE178F6A56C" modified="2019-02-13" version="1">MNIIDLNAKIFLYFLNFSASTSHSSATYENAHVGTPTPSTASTLVLGTQGRGASPKVIQSLNNALNGKGHRFSHVHLQTPSKCAHCTSILIGLDRQGLFCQDCQYACHVHCAPKVPTSCPVPPEARRPLGIDPQKGVGTAYEGLVKTPKPAGVKRGWQSTYVVVCDFKLYLYDCNIDKHGKAIDIHPMIRQVFFVLDMRDPDFNVSSVIESDVIHASKSDLPKIFRVTTSQIHSMLPTVTVNTTGSNSSNGSAGSDTPIARHLTFQEKTKWVIALNELKNLLRKSKLVDKSAFLVKEVFDSLTFRELRNAQCATVLDKSKIVMGFADYGLYAIDLDREILVPIGGERENNKRTVEQIEYNADEQLFVAMVGVVKERHIRLIPTAALDGRDLKWIKVADTKGCHLLTLGAGSSNDPHNYFCVAVKKTVLVYQIDRSEKRHRKVRDLAMPGHPQTISIMRGKLCVGYPSGFRMWDLADNSTTALVNLEDASLQFLNQTLYDAHLIINVSGYEQKEFLLIFSRLGVYVDAQGRRCRSQELMFPSEASSGGFSCIMPHLCVYSENEIDVFNVNSAEWVQTINLRKASPLTSDGRLTVCVINDLPYVVLLSDVLSDEDVLSLPDWTQPSIANIPSSSSLIKGITAKRRRKFSMKTPREDDRYGRSGDRRSQLPISGPSDFVHIVHMGPGAGLELQNLIDLKNSNPSHVTSSSSLGSGAADKVRQLINPIMRSTSSTTTNLHGVHQLTNTSRREIELMQSKSRPLSSHSKGSDGIGVLPKASITSTNSHFLELKAVQKDAVKTNQLHWDTTTEPCLPSRSRSSLQIKQKRHNSQHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PMQ8</accession>
    <name>A0A3P7PMQ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PMQ8"/>
    <dbReference type="STRING" id="318479.A0A3P7PMQ8"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017957282" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="522"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="706" mass="79664" checksum="A9DB0D938DE429A8" modified="2019-02-13" version="1">MWGCVMLLERLLIIATMVDSVFSIDLHIGGVFPMEAGSGGWAGGQACLPAVQMALRDVNANRNILMGYNLVLHHHNSKCQPGLAAKQLYELLYRSPTKLILLAGCSPVTTIIAEAAPVWNLIVLSYGGSSPALSNRKRFPTLFRTHPTANMQNPTRIKLFHKFKWKRITVLQSVEEVFTSTAKDLENQCRDSGIRIERQSFYGDPTDAIKTLVRQDARIIVGLFYVTEARRVLCQAYRHGLYGRKYVWFFIGWYADTWFIPPPEEPVNCTVEQMTIAAQYHITTESIMLSKNEQKTISGMTGFEFQQKLMDIIKTDPANTGGFPEAPLAYDAVWAIALAFNCTLTRLSNSQTLADFTYNNTVIANKLFNCVKNTQFKGVSGQVMFSDLGDRIARTQIEQLQDGKYEMLGTYDTTTSHLDWYGKEKFATLNGLAPPDSTIIKESFLTISIELYYAVAAFAIIGIFLSITIFIFNFKNSSRSIIIQSQPKCNNIFIVGCILCSFSLLLMGIPADGITLPKESFTFLCHTRISLLMVGFTFGYGSMFAKVWIVHRVGASGNQELVSQQKSNDPISSKKFYLIIAIFFIIDLIIIVCWLLYDPLQREERRFPLQEPPPGTEEDVMLLPILEYCQSKRHEIWTGIIMGYKCLLLIFGLFLAYESRNLKLRYINDSRFVGLAIYNVTILSLVTGPVSWIDIYSKSPSFKPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PRY1</accession>
    <name>A0A3P7PRY1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">X-box-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PRY1"/>
    <dbReference type="STRING" id="318479.A0A3P7PRY1"/>
    <dbReference type="OrthoDB" id="20960at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14691">
        <property type="entry name" value="bZIP_XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="230" mass="27187" checksum="061629B0E3AC661C" modified="2019-02-13" version="1">MHCEVEKLIGNKSTSTATIRRRERLTHLTAEEKQNRRKLKNRVAAQTARDRKKERTFKLEQALRLLCAENKSLREENQSIKVKLLEAEKRNGKLEEKLKRIENERKNEMKSVDYISGAFSVESAEFINEPQQRAQVMLPQVLIPLLIMLIALIYKASWTNYLNQILNLTNSVNKFSTKKVSPFKIHHHHQNHRLKFRMNMIMQKLLARTKWKCRKLLTPVEQIALPYIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PTU0</accession>
    <name>A0A3P7PTU0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrator complex subunit 4/Protein SIEL C-terminal Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PTU0"/>
    <dbReference type="STRING" id="318479.A0A3P7PTU0"/>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="4">
        <location>
            <begin position="550"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="695" mass="79423" checksum="32FCF68F1B267E0A" modified="2019-02-13" version="1">MKVVTVRAEAARLLGLFERVSDSFLDQTLDKKLLNTMRFTKESDRDSRKAFHKSQQKVSSQWSTGKKLGEDIPAEKIEEEQTSMISIGACGAFVTALEDEFMVVRQAGVYSLGKLAADRPFFAADAIDHLADMFNDEIEEVRLDAVRALTPLVVHGVLQKEQLDTILTVLDDALPDSREALRILLGKSTLASVECLRFCVEALLNCLRRFPIDRSSIYLLIFFCCRNISRIFRCLSQLGRRHASFVQSMVYDLLELNPVFDITERSLEDYMYLAKLIFILNAASIHEPICSLLPEFAVRHYRYLRCSMSNLVPDVPTFSTQDSINGVLLRSPMDDNKETRTLLERSYEVMLEASMAESYEQRMVLQKFILKDLVILYEANEKIASTARFLSKLMHCFTCHDLIIQMITFGGDLLTTLSVIEEGLLIIDYAENEFHSVDNVVLSSLAECAFRLRILRFALQLERKPSLYQNAVDAFAVEIDFLKRRLSFLETTPSKSIMKLIDEIMEQIEYSETKKFVTCPGLTSLLQTKVLHLPHQFPSLGKIFMKWAEMVEPCETPSEPIRFIAGLPLAIPLNILLHNFNESDLRNFRIKVDYPDQTSNLFRPRQSDFKEISSQKVRLLCKVLVQSSAWSDAARVRLSCVLILPDRPFIHLMQDNSQFDIKDTQTRCISISVSPHSTKESSIDIPVYPMFGKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PZR2</accession>
    <name>A0A3P7PZR2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PZR2"/>
    <dbReference type="STRING" id="318479.A0A3P7PZR2"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF521">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="176" mass="20264" checksum="3F09167C6CC8C595" modified="2019-02-13" version="1">MLISKLKKLEKEILGSQLIYILKLSAKATTSSSKTNFLPLNFNYLIVTSKKTKSSKRMEKEIICTQGPMPSTTEDFWRMVWQEKCVAIIMLCRVIENGKKKCEQYWPLEADEWVIKFVVLGIYENSKVLKVKHVLWSAWPDKGVPTSTTSALKLIFRTQTYSPCVIHCSAGSFHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q5Y7</accession>
    <name>A0A3P7Q5Y7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q5Y7"/>
    <dbReference type="STRING" id="318479.A0A3P7Q5Y7"/>
    <dbReference type="OrthoDB" id="10053392at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="38022" checksum="4E002C0A08D5B8FB" modified="2019-02-13" version="1">MITTISDDENVDKSGLFLNLENDDIPEPVIVTAFSEDFSLQAKRLITSIRQYWPHQVIIIYDLGLDESNIQLFKSLCNIIYRKFDFNKYPPVVSNLYSYRWKPIIIAEVLQEYKAIWYVDSSVIFKKNDLNHVYELMRCPSKMLIPEIADRDLREQFTPLENGWNIETWMRNIAECRKSTYLFHGYSGHGIFSATNPGTYKFIPTNFDEIKKPKAKMYEAGIVYVIQTAETIRNILKWYVACALEEQCMAPSNAKLQCNFDENDRFGKYANCHRYDQSVVNLLAANAFLYDRHYYVSEIVDFFGVVRANNYFINSGSFILSCNNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QKE4</accession>
    <name>A0A3P7QKE4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QKE4"/>
    <dbReference type="STRING" id="318479.A0A3P7QKE4"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="185" mass="21011" checksum="8CB230DD811AE0DE" modified="2019-02-13" version="1">MVLVIGDFHIPLRSHGIPAKFRKLLVPNKMQHILCTGNMCTREIIDYLRSLASDVHVVRGDCDDFGLGYPETKVLTVGQFKIGLCHGHQIVPWGDIKRIELLARELNVDVMVTGHTHQCRTFEHEDRFFIDPGSVTGAFSPIQSEVVPSFGLLDVQSNTIFAYIYRLIDDQVKVERMQYRKQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SD09</accession>
    <name>A0A3P7SD09_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SD09"/>
    <dbReference type="STRING" id="318479.A0A3P7SD09"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="259" mass="30787" checksum="5EBF4CA6E5D42336" modified="2019-02-13" version="1">MPQCLIIGVRKGGTRALLDALALHPNIRVVRRELHFFSNNETYLNGLEWYRQQMPYIDNNLQITIEKTPAYFTNELAAERVYHMNSSIKLIIILRDPVIRTISDFTQVLYTKFERNKSQPIFEAEAFLADGTTINIAYKPIRNSLYSLHMKQWLKHFPLKNFLILNGDRFIIDPSFQIKKVERFLKLSQSIEPSQILFNKKKGFFCFRQKNRHKPRCLGETKGRAHANISMETKLKLRRAFLSYNLEFFKMVNHWWNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SK55</accession>
    <name>A0A3P7SK55_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GLE1 RNA export mediator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SK55"/>
    <dbReference type="OrthoDB" id="5836200at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="446" mass="50772" checksum="619CFA082CDE90C4" modified="2019-02-13" version="1">MPHVNNSAECISYVDVSKSFFIEPLDNSATKKPYSSTPLNKVSHLLLARTDSHFISKTSTVNFDSDVSSIKIADIENENTSEIIDRKTEFYEYSPLLIFCTNVYSKEMIEYFENFVQNFEEMPKNSSRMELKRTINEKIAVVSKKLATDDEIMRAVMYFSNLLSGLAVTGFNDKIINLSNDSTAVRWAISHIISTFIDIVLQDQLVIHVVCKILVKISNKFKEFETLLWMKLILSSLLLRKDYNLCTKMVEYLHKQGEDVSGTINAWKTREIVIIRLFVLLLSSKSSVDNSYCYSSALWNITATAVNEISPFASAILNEILQHGSKSLKEIYGSQFNKILKLVEKKVLPRWKAETDRTFHESVVRPLFEHFTSTMLEKEVYSINGNNWVGSMLDLLANGENYNSVESLKLNYGKRTIKRISSFGGISILVLHRTSVGYPIGCVPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T0Y9</accession>
    <name>A0A3P7T0Y9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T0Y9"/>
    <dbReference type="STRING" id="318479.A0A3P7T0Y9"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF15">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0868">Chloride</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14210" checksum="1AC1AE079B9A70E6" modified="2019-02-13" version="1">MFSKAKSGEMFNAVEKSLSNKQNSLSRVIDLDEVAIDSAPFQLVLGSSLYKVHTLFSLLGLSHAYVTDCGRLVGVIALKELRNALANIYIRGAVPVKVDRKLTSSGYFVPKLFKDSLLRQEEEFDNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Q3</accession>
    <name>A0A0N4U0Q3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4500</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sprouty family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Q3"/>
    <dbReference type="STRING" id="318479.A0A0N4U0Q3"/>
    <dbReference type="WBParaSite" id="DME_0000014001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000014001-mRNA-1"/>
        <property type="gene ID" value="DME_0000014001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5786858at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF9">
        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000014001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28018" checksum="E930B79FF52934B0" modified="2015-12-09" version="1">MLSFSRVKLKLKSNLEQSSLFMKKSEETLVPTDYAFNRFDRSNDSGENEYINAELNVLPPSDQWNIVSRSPLSDKTKAADYHSISMLISNLKYQCGIENSKKSVKRMRLVPNYNQGEICFQSCINILIKKEAPNPIKKLIQRLTCLPIAQAIIYHCCKDENDYSPKIGRFGQGYNICTCVLPLTNKRIKRWLILALISLFLPCLCCYLPATFIYRSCCCCQVGRHKPFNNTDRARNQNTEHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0U9</accession>
    <name>A0A0N4U0U9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic dynein 1 intermediate chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4553</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0U9"/>
    <dbReference type="STRING" id="318479.A0A0N4U0U9"/>
    <dbReference type="WBParaSite" id="DME_0000019301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000019301-mRNA-1"/>
        <property type="gene ID" value="DME_0000019301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000019301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10765" checksum="7D64880F5C0DE357" modified="2015-12-09" version="1">MTSKKEAEERKLELERKKQRLAEMREDKRRREEERRRNLLRNIGIENGAASGPPKTLLQKDLDEILEPVGIPSLPPIEQSPAAKSDSQAIFSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0V2</accession>
    <name>A0A0N4U0V2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4558</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0V2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0V2"/>
    <dbReference type="WBParaSite" id="DME_0000019801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000019801-mRNA-1"/>
        <property type="gene ID" value="DME_0000019801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000019801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8205" checksum="EBBDDF932817275B" modified="2015-12-09" version="1">MPKQITEIKEFLLTARRKDAKSVKIKKNSENVKFKVRCSKYLYTLVIQDKEKAEKLKQSLPPGLQVKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U228</accession>
    <name>A0A0N4U228_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5063</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U228"/>
    <dbReference type="WBParaSite" id="DME_0000070301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000070301-mRNA-1"/>
        <property type="gene ID" value="DME_0000070301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6146255at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000070301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11065" checksum="F36CAEDE2D55FDB9" modified="2015-12-09" version="1">MESDRMAYTRFKGKFCNISVSVHDPTLSADDRDTFYAKFQLLTTFLQKYHMVIIGGDWNARVGHNTAAMTSAFHKHGIDRCANEVMPSSLNGRAWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U294</accession>
    <name>A0A0N4U294_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5142</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U294"/>
    <dbReference type="STRING" id="318479.A0A0N4U294"/>
    <dbReference type="WBParaSite" id="DME_0000078201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000078201-mRNA-1"/>
        <property type="gene ID" value="DME_0000078201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000078201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="62828" checksum="19C9030F07960985" modified="2016-06-08" version="2">MQKREFYRAAYFLENLKDNSEFDRFMYYFARYLACEHNRLENDADAIFRQEKFDYSEMISLHNELNELGSMNPSFFDVFLMYILGKIRVSLRLKEEAKIAFLECLKFNRAFWPAWEALVNLIGSIEEAGKYEYIDSDHWMYQFFKADIFFRMNLHKNALDQYERISEAGFTNMPHILNEIAACLNYLQEHDLSLEIFKKVRKMDPYRVDQMHLFSDSLYVRSLRSDLSYLAHSFYKTHKFKWETCYIVANYYSLRGEHDRAVTFLQRCLKLNPQNSSAWTLIGHESMEQKNHSAACLAYRRAIEIDPMDYRGWYGLGQLYDILKLSSYSLYYYHKAHKCKADDSRMLVALGEAYSDLMRYNDAQKCYLRAFKVGDVEGTALMLLGKLYEKEMNTSQAALVYEKYLNVYGEELINDGEDVAYCCIFLARYYMNKGDLDTSSSFAQRCLEFDLTKVEGRNILSLISQSHHRMSLIPSSTHIAITSTPSVTAPIAGDKQLPSDAMITPILPKVTVSAPLQFRSPAQDDGEVDMLISSEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2K8</accession>
    <name>A0A0N4U2K8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5280</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2K8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2K8"/>
    <dbReference type="WBParaSite" id="DME_0000092001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000092001-mRNA-1"/>
        <property type="gene ID" value="DME_0000092001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869233at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="1726"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000092001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1883" mass="203190" checksum="7BEB0F53405F6E2C" modified="2015-12-09" version="1">MGERTIIKRSNSEKPSFFEDIYGSSQKESFEISDSSIEGSPILKVRNKTTDTKASVIPAHLTFRHYEDAAGAHESHSIETDHDALKPEIPPNYFIPRCYTTFEVVPNADIANFQSTKEGKTESADYCAAFCYNSGCSAAVYEPSKISGVKGKCKVQFGGRDQCGPDLQRHYHIEPNEPVYIQSSPPGCDLKALMNLLQNQSSAIHETSSMPPTVSTIRISTENMASLTESTVPTEAQSKISETSSASVASTTEPSEGAETTEQSQPTSEQPFISSLGIESTPSEGAETTERSQPTSEQPFISSSGIESTPSEGTEAIEQSQPTSEQPFISSLNAIQNESPSVAESVDEPIKKLNGTQLQQAGEKYSTIFSLQCSHFICDLEDCIVQFQAVPFDSSNTEHNLSGFISSTKVNSPEICAKRCYQEGCTAAKYDPTSEDCILSYQDGQICSPGTKIYTVKTTQPIWIHCTSCRANTLPKVIPEKLQVCHFIPIGSTESFPEITTKSLKPLEKISERTEQTVGITEISSAMMSSSTQSESTSEETPVDKISIETTSSSELSAEITKSAVEISESILSSPTFETSESPTETTETQSSEISKIITPTLLSSEASGNIIVTSETTPQTSESHETTSPEQNAANLPSGISEFTSAPSEEISGKIEQMTPTFDKDIELSTKSLEEMSEIPEKIAASIVTTAVTPAISLETSEEVSATSEQTGKTSVGETSEGSSQTMQSNKITGSPKESEASENEKTTETQISEINDTIIPTLLASGITESVMEISKSMRITSLSPTSEGESIKTDSSKINEITSLKTPAVTKIKVETVETASTQVSSTSSLSLQQSESTGSPKETDEVSEGITPSLMASEITGSAAETIKAMLSSPPIKSSENATETIETQTSEIIVTPVLLTYEVTSGEANETPPTRTTGIPSELESQTIDISEITMPNLKPLETITSSEQTTIETNEAILPGSESLKTTTSEQTITSLPSEETGFVSRISEKTEQTMDRPAFKEDIRSTTKALEEMSETSQKASDGGLEVATPSSLEISAEAGASSEQTISVSETTKESLEQSSISEKLAPISNFVSEGVTENLEETTKITRSEVASSLKSSETIETNEITSSHPSIEISTESPLSEIKTTQLSSEQESSDEQAIKTKIAQNELVDEEHECRVSFQAHPITDTESTASFEIEKDVSDPNACALACYKAGCTGAKYGIKAKKCALSFSEKQQCDGHEDTQEINDSSEAWWIHCLSCITTENRNHNRLYLPIPEKTESTDNNFVFDVGKFTTVTIFEPSESSISSGVTAEKSSTTAGWMSPRFEHTETSESATTEKASEPLTESSIELPSGGSTRATPLESTELLAMSTKETMSAETYGSFVESSIGESTSIRTVLPKSVSFTSTEYKTSISEPMKLFSTESIQPSREAVSFLPETTSEVTEVSTIISGATEAKTAKSAEFTSEPVSEKGFPTNSHEETSTTFEKTESTGIITKALGESTESPKVLQKVTIQQHEGASSHSGSERELIPEVLSSPAFSTETSALPEEHFSSSTDEEKSIAITEPPIREVSDFVDVLSQNKNLGEILGRTTIAPSGCAKGNLTFFGREIANLHVHFHADMQVESVNECLQICHTLQCSMAAFTRDPTPTCLMQLSPMRSRACDSLDPSLRVPTWNLADDKNVLLIQCIQCGNEASSDDIFPVVPRSIDITHLLSAQRKHAINSATMAKDGEDSRCFGRIEFQTMPVGSLPRLNITNDIPVKSAAECADKCYNTKGCFVAGYIPNPLGSSTEDVCLLTSDINVCPSSNFVPQYISKRAFIITCLKCSACKYTISAAPSDHFETTNDDSATAFSIDQCALECFRRKSKKNEGCPREMPVNVTNSVLLECVTCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2X5</accession>
    <name>A0A0N4U2X5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rad4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5416</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2X5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2X5"/>
    <dbReference type="WBParaSite" id="DME_0000105601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000105601-mRNA-1"/>
        <property type="gene ID" value="DME_0000105601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="552"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="606"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="684"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000105601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="846" mass="98326" checksum="5ED942D89026E790" modified="2015-12-09" version="1">MAKKKRKQSKNNCTQKNIKSHSKVVEEKNEKYGGESMIRDSKDHADSCRKRKSKLETTSAVQKKSRRLLNKKCIYENENQCDVANEDESQCNVTNENKKNICRDGVNKLRRPKLVLKVERNSTACLKQVKCKRNAIIRARKQASISQNEDKKSVVANEQFIKQEYISSSGSEDEWEAMEEMDIPENTETSAQADLEFIINEPKKEESEESKWAKFLRLEVNRKIKERQINCHKMHLLCYIAHLRFWIQSLIRNEILTPLCLSLIPEGYVIAAQTNFSEDIAEKFFKWFRSAFSPSTKKYIPRNSSCEAQMERLEQLISNRVYEFDRDIASVLFLCLFSLKISVRLCLSCQPMPHKLSIRSFLQSSASKNSDSLPKASGSQIKIPAATECNKKSVHLTKKRKATYDSKCSDDNISIDLSEGAAEDQNNGRKIARGARNFTKTKNEIRAYRNYWIEYWDEQNNRWICVDTWKGTIDMPESMEADTTPPMHYVIAVDENYGMRDITDRYASKYLSPEMRRIRIDSEWWEKTMKLFKSKNRVRNRFETIAVHDYLCSKPLPTTIAEFKNHPLYVLKKDLLKFEAIYPEDQKPVGYIRGLEIFPRSSVHHLQGSLNWIKHARSIKHIDGFFKYILHIKIKPGEKPYKVVKARPNIKVPEELRQPRTLDVFGYWQTEPYKPPDVTDDGKIPRNEFGNIYLYKECMLPKNCVHIRLEGLVSIARKLDVDCVPAVVGWEFHKGGNHPIIDGCVVLAKHEKALREAWSAEYERKRVASLKKKKERALKNWRRLAKGLLTLKRVRAKFLSADQRPMNTDETLDKEVVVDTNSSMAWPHIAFTLPQVDKSGEDISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U321</accession>
    <name>A0A0N4U321_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5467</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U321"/>
    <dbReference type="STRING" id="318479.A0A0N4U321"/>
    <dbReference type="WBParaSite" id="DME_0000110701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000110701-mRNA-1"/>
        <property type="gene ID" value="DME_0000110701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5776602at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000110701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="31567" checksum="4FC866B0330A06CE" modified="2015-12-09" version="1">MYCSPTHPASCPVGYRCKTAVNEPDTFVCCSMDLPETCPQNFIPVFDNTRCSPNNPTTCPGGSICVESRVARNMFVCCRRAESPIVCPNNQEPLLFPNGKVETCSGAGAVCSKAGYTCEVSLAMSSWICCAHKAIAATCFDGRETFYQIQAGKYPSGCPVNYECAPSNVNGISVCCKIEVTFGCPIGWNPYRNEIDSKFHFCRNVLDNNCPTGFSCTQSTQVGIFICCRFGATLNCAPGFRTLLSNNHPRLCNNVQANICPTGYTCMRSTVVCFLKSTPIKFANSDNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U342</accession>
    <name>A0A0N4U342_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5494</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U342"/>
    <dbReference type="STRING" id="318479.A0A0N4U342"/>
    <dbReference type="WBParaSite" id="DME_0000113401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000113401-mRNA-1"/>
        <property type="gene ID" value="DME_0000113401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF20">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000113401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32405" checksum="7192A13FCB4B817F" modified="2015-12-09" version="1">MSFGIFVIIPHVVTIAGPLAMLSLLLAFIVMIVSVMHVNELMSSMPKTCLLYNFIYACFGELPAFFTAWTALLDFIIILVIIAKSWSDHTKLLFGGFFHEYLVIKLSFSVNNEILEDEIDGFAMLIIIFSIVILCCNLRVSGTIAFVMLIVSGLATSSTILVGFFNANPNYWLSSKFFQRGMHGVFYLFYLFILALTSLLEETHNPRRRLPFIFSFITFLYSLLIFITIMIFTLTNDSTNFSIQMLPDIFNNVKIPAARFIFFKLFHWMQKKILKFFFKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3H7</accession>
    <name>A0A0N4U3H7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5642</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3H7"/>
    <dbReference type="STRING" id="318479.A0A0N4U3H7"/>
    <dbReference type="WBParaSite" id="DME_0000128201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000128201-mRNA-1"/>
        <property type="gene ID" value="DME_0000128201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000128201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24389" checksum="BFDC3B25E68FA640" modified="2015-12-09" version="1">MKNSIILLDFKQLERNASVVSNSNNVQQKFLVWLTVHVVNGRLERDTCFGENYNDVACDTRNEANPKQLEAGQLPRIGYIPLAYRKARNLAVDAVLVPGLNWKTVVETIERILPQLEAVGENLEHWNTDSDETWSVIKLRQFLGKLIKRNDQVTKSQAPMIVIIREDLVRFVTKIIGIVIETYPTLKQRLERLIKIKACRKCLKGGHIEANCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3J3</accession>
    <name>A0A0N4U3J3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5659</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3J3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3J3"/>
    <dbReference type="WBParaSite" id="DME_0000129901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000129901-mRNA-1"/>
        <property type="gene ID" value="DME_0000129901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000129901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35412" checksum="6FE93229E474B383" modified="2015-12-09" version="1">MAIMDCIMKENDVSAVQVALRIRPQVAREKLELCRICTSVTPGEPQVTIGEDRCFTYDHVFDQQTAQSNIFESCVANLVAGTFEGFNATVLAYGQTGSGKTYTMGTAFDMIDVINEEEVGIIPRAIKYLFNEIEARKLQAREKNQFEPVFDVAAQFVEVALFNILYNEEVVDLLADDRNSSITLRIHENYNGEIFLHGVTKINVSNPDETLMVLKNGALNRKTASTNMNEQSSRSHAIFTMFIKQRRGCILPTVNVSIIFFCILLLYVISTRNFYFLLVTIIYFHDFQKARVYSCIYLGHLSFDRLVQERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3M0</accession>
    <name>A0A0N4U3M0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIBORED_LARGE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5689</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3M0"/>
    <dbReference type="WBParaSite" id="DME_0000132901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000132901-mRNA-1"/>
        <property type="gene ID" value="DME_0000132901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000132901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17368" checksum="1C7196A2335C22B5" modified="2015-12-09" version="1">MRRNQAGVRPIRGYANEIFTLKRSMYMANFYEIKTDVRQDCVLSPTVRTRLDNEASLAGIQDANQSRDFEYADNVFLFAASCNKMLSITTARTGFKISNYIFPVDETFMESSQNRHKDENPCPYSCNSLDLAIWLRNMANESGGYQEVIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3V8</accession>
    <name>A0A0N4U3V8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5788</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3V8"/>
    <dbReference type="WBParaSite" id="DME_0000142801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000142801-mRNA-1"/>
        <property type="gene ID" value="DME_0000142801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000142801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7263" checksum="A86343560E59E082" modified="2015-12-09" version="1">MVTANNLCKNVICSQGLSCDGNTGKCAKFRQFNYEFANLCSNIECPGNTKCDTNTGFCVLFRNINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3X6</accession>
    <name>A0A0N4U3X6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5809</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3X6"/>
    <dbReference type="STRING" id="318479.A0A0N4U3X6"/>
    <dbReference type="WBParaSite" id="DME_0000144901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000144901-mRNA-1"/>
        <property type="gene ID" value="DME_0000144901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000144901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="57499" checksum="D526C6EF06A66621" modified="2016-06-08" version="2">MIETLSSFQDDMLWTIILGFFIASILSFAIGANDTANSFGTSVGSKVLTLHQAYLLASIFETLGAALLGYKVTDTMRKGVIDLNVYNNSEHELMLGQISVLSGCGAWLLLATFMKLPVSTTHSIVGATLGYTLLARGTRGIRWWPVLRISVLTFKLNLVLSWFVSPVLSGIVSVIFYIFLDHAVLRRRRPLHCGLVLLPILYFVCTSVNVFAIVYDGSEFLGFDKLPLSAIISITLGIGLLVAILIQFIVAPRLKKSILDASCKDQPMQVYSNNGVEVSLKSSLQSTNTLGQNNTQSTKSLLKCESGKSWNPELNVTPNECQDDSAEQTSSGHIHHGIGANTVRPTHSIESFFRSSKPEDPQASKLFSFLQVLTACFAGFAHGGNDVSNAIAPLVSLYSIYKEKSVLQKSPTPVWLLLYGSSGMCAGLWLLGHRVIYTVGENLTKITPPSGFAIEFGAAVTVLLSSKLGLPISSTQCKVGSVVAVGLVQASHSVKWSTFRNISLSWIVTLPVTGFVSALVMFFLQLFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4B6</accession>
    <name>A0A0N4U4B6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5978</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4B6"/>
    <dbReference type="STRING" id="318479.A0A0N4U4B6"/>
    <dbReference type="WBParaSite" id="DME_0000161801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000161801-mRNA-1"/>
        <property type="gene ID" value="DME_0000161801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000161801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25800" checksum="B290232624CB143E" modified="2015-12-09" version="1">MCRLQAKKLQSFNKELQIVKCRYYDAMCEEKLQLVVGMSKEQMHLELRDKNNEFIAMLNDDCAILENMGICDGMVIHAVSTFGESNLLNDSSMVEKYELPDADYEKRSDSVRAWMRQKGFNKSHSSKEIDNAESVKHFKIGDRCKVILLSQQKKLGEISYIGLTDFKPGYWIGVTYDEPVGKHDGCVAGKRYFSCADKHGVFVRPRDIQVISSESEEESGDEAMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4H9</accession>
    <name>A0A0N4U4H9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6052</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4H9"/>
    <dbReference type="STRING" id="318479.A0A0N4U4H9"/>
    <dbReference type="WBParaSite" id="DME_0000169201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000169201-mRNA-1"/>
        <property type="gene ID" value="DME_0000169201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000169201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48194" checksum="4EAD34B093CCFB07" modified="2015-12-09" version="1">MSLEVNDANLKPCHHSNELTFSPMQATFRIYIIPSMCFFGIFANLINICVFGHKQMVSHLVNHFFLALAVADLMVFFSTFFVFSMPVIAEHSGNFIFVDKSPVFLVFFYPVAHTAHMTTVYLTILVSVHRYLAICHPFLIRRISSPNAVKYVIFGVILFSILFNIPRWFELENEACISETFHSPAPLIQNYDFIIAYRIVLFIVVVFLIPFVTLTIVNFKIIEALQSSAKLVLLISYGITVMLVAIISEFLLFNVLSFVNNIVELIFHSSYFQFLVELSTVLVNLNGATTIIIYLIFGSKYRTVFFEVLNFSLKFYSCTINIRRSRARCSLSNYQRIFKNCICDNYWLQINELPIWAYIFAIIFQRKSLHFLCCSFIFITVRQKISENSTKNSLTICLKLYFQRTEINLNALSHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4R3</accession>
    <name>A0A0N4U4R3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6147</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4R3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4R3"/>
    <dbReference type="WBParaSite" id="DME_0000178701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000178701-mRNA-1"/>
        <property type="gene ID" value="DME_0000178701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000178701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42797" checksum="3EAB1E94DA049F5C" modified="2015-12-09" version="1">MFAKRSAKKRTEENESHGATSNQPFQQTEPIHVATNIYENIVASAPFLYHIIQECPVFCCYLTHPDQPPQPSARISVPRHHLQQQALPAQHTSVSAVCLCPVASHVPFQLPVIADDHSFIHAQFSRIILFHLKYSCINEQIFTNLQVTRQPNVNKSHGKRNAKYKTILCNKFAKNGNCPYGNECHFIHEISEDKRTSEKGNSDNSKEIENIDSSIIQVKDGLQCSKSIALPEETRNDARKSYSFGDVARLDKTRNDARESYSLRDIARLYGARNEARESYSLRDVARLYGARNNTRESYSFGDVARLDKTRNNARESYSFGDVARLDKTRNNARESYSFRDIARLYGTRYDARESYSFGDVARLDKTRNDANDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4S2</accession>
    <name>A0A0N4U4S2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein pellino</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6158</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4S2"/>
    <dbReference type="STRING" id="318479.A0A0N4U4S2"/>
    <dbReference type="WBParaSite" id="DME_0000179801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000179801-mRNA-1"/>
        <property type="gene ID" value="DME_0000179801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8801906at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="3">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino FHA" evidence="3">
        <location>
            <begin position="145"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="4">
        <location>
            <begin position="406"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000179801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="553" mass="62359" checksum="82F997C9ED25813A" modified="2015-12-09" version="1">MSAVNKERACCNDGGICKYGELIVLGSSSLDDEPLWKVKRRRAKLELFKRASSNGIKKGCSSSVNVSPLRNEAIMNPSKHVVSYSFPGHTVIVEYIPDNTKDMFQVIILLNIFQTVKESRILVAELHTYVASSVEVQQHEFFLTRNEAAFFKIGRSTEPQIDFTVVDSWLGAGDKIVVSPRDSNFYVDSLLQANFDHKGHVVSEVPISSTISRYACRILIDRKEPHRAFLYAAGFDASSNICLGEKAIKWTKENGEMDALTTNGVWILHPNQKPSEKIVNNDEAVNLFNWREVSLDGDIYEVRQLRSSSKRGKFLTSETNELRDGTLIDLCGATLLWRTSQGLAKSPSFSELDSRIKIGDKEHKAVPLMDYNRTAQRGLVSLKNTGVSELLLLFLMWVKILRLNELNAGKPQCPVNLNTLIVSRKKFLGKKESSRQPYVYIACGHVQGKHDWGIQKNENSCTTYKCPVCLEKSTRVIQLVMGMEPAFHLDSGILNYAFNPCGHLASFATVRYWSRISVPYDAYNHSSLCPFCTNLLDKNKPYVRVIFQDHLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5G6</accession>
    <name>A0A0N4U5G6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6449</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5G6"/>
    <dbReference type="WBParaSite" id="DME_0000208901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000208901-mRNA-1"/>
        <property type="gene ID" value="DME_0000208901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000208901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="13937" checksum="A47D5CE38F58D9CF" modified="2015-12-09" version="1">MAANGDDIIEGEIDGVVVAIVVVDNSVDDEESGVVVAVGALDNVDVDGTVDDAGNDPSVGDGGDGDVVDDDAGDCVISDDGGEAVVEAVVANELVDDCGVGEDNDDAIAGDVGSGKSVSLFVGEEVVVIGRDVLGDSSELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5S5</accession>
    <name>A0A0N4U5S5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5S5"/>
    <dbReference type="STRING" id="318479.A0A0N4U5S5"/>
    <dbReference type="WBParaSite" id="DME_0000222001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000222001-mRNA-1"/>
        <property type="gene ID" value="DME_0000222001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6363067at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12940">
        <property type="entry name" value="LEM_LAP2_LEMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000001">
        <property type="entry name" value="LEM domain containing 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051656">
        <property type="entry name" value="LEM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019:SF9">
        <property type="entry name" value="THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000222001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7601" checksum="C939B269E99FBC9F" modified="2015-12-09" version="1">MNIDELSDNEIRQKLLERGINTGPIVATTRNVYANKLQKLIEDSTSSANEKVEQVRSIFYNFFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5V8</accession>
    <name>A0A0N4U5V8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6625</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5V8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5V8"/>
    <dbReference type="WBParaSite" id="DME_0000226501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000226501-mRNA-1"/>
        <property type="gene ID" value="DME_0000226501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000226501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20349" checksum="4067822E9AA15E24" modified="2015-12-09" version="1">MRPLTDEETEIVFKKLAKYIGENVRLLIERGDSNYCFRLHKDRVYYCSESLMKKAACVAREQLLSFGTCLGKFTKTKKFHIHITALDYIAPYAKCKVWLKPNAEQQFLYGNNVVKSGIGRMTDGALSHQGVVVYNMNDLPLGFGVTAKGTAECRKADPTAIVVLHQCDLGEYLRKEAFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5X0</accession>
    <name>A0A0N4U5X0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF229 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6637</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5X0"/>
    <dbReference type="STRING" id="318479.A0A0N4U5X0"/>
    <dbReference type="WBParaSite" id="DME_0000227701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000227701-mRNA-1"/>
        <property type="gene ID" value="DME_0000227701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000227701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="63386" checksum="F0D88123A2A6DBE5" modified="2015-12-09" version="1">MKCKIPKLEINGSEVIHFFDKAEPLNCDLESKDWIYMDSNRIIKITNDAISKYGEIICTMKAYRSPDDIKVKFDEGIEFRKEVQLNSSDFAKFICKTSSENGRVLPICYSFALIININKKADKILRILSLMTIAPQKERIGQLTKIKKPNDWSGLDVYFLGFDSVSHMTFRRKLPLTVKFLEENLNAVVLNGYNIVGDGTPQAFIPILTGKTEEELPLTRKRFKRARFVDEVYPFGFKKQPTDHYLRTYFIEAEKRCMENSKCKCLDSRNLYEDWFRYTSEFMLRYKALPRFLLAHQSRYSHNYLNLVELQDEHIVEHFIKLLQTNVLNNSIIVTMADHGHRFEKIRQTHQGQLEERLPFFSIAMPRWFRESDKGRTAWKNLQENKNRLTTPFDIHATLMDILHWPSEDELKRPGDLKKRSLSLFRPIPSSRTCAQAGIDPHWCTCLKWKSAMSPDQINISKMLADVALDTINLHTEPERKICAELHLVPNVSTIFLTTNLTELATIIIDNFSGMNPALIVSIGPFLYISFILHRFTDSHIDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6G3</accession>
    <name>A0A0N4U6G3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6868</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6G3"/>
    <dbReference type="STRING" id="318479.A0A0N4U6G3"/>
    <dbReference type="WBParaSite" id="DME_0000250801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000250801-mRNA-1"/>
        <property type="gene ID" value="DME_0000250801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF105">
        <property type="entry name" value="CYCLIN-G-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="7">
        <location>
            <begin position="645"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="1083"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000250801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="129123" checksum="CE0EDA7F5F4C98DA" modified="2016-06-08" version="2">MLKIKKHKGVSFYFSVTQGRLNFMIDRNRPALIFLSRFIPFQMSDLFRSAFNYFNLSPVCAVPIGKIDHPLVGTNIEVGGGFALVFSAQDSQGNWFALKRQLAADRETADAIIKEIRFLRELTDHPAIIRYVQAAQLNQQESGHGRTEFLLLTELCSGGCVSEVLQRKPFSLSEVLKIFYAACSAVFHMHAKNPSIIHRDMKIENLLFDSCGFVKLCDFGSATTEVFFPNDSWSVQQRQRLEEELARHTTPMYRSPEILDLYSNFPIGPAQDVWALGCILFYLCYRRHPFEDSAKLRIINANYVLPEGDTGYNIFHPLIEQILQVDPRKRPSIVNLCEKLSSLANSLSVDLTKPLDDLQLPQLTSVGQTSASISATTSQLHQELMNIGEKAKNFATSRSSPITQQKIDHVRLFANIVFFGNEHTAQQQASAMLGALKDQGLSWFKTIKEKTTSVAQTVQSTYGGRGPDITFLTSRLVIAPLIEGVPEPLSTQAEEAMRQHIIERMRNDFAVFNLSQRCLRGNYGKRLNEFPMHQVGSGIAPTVTNILALCSTIGRYLNENNTNVVVLTGPEVFYMDNLINLAQCILLAVSLMLYVRLVPRPLFAIEYICSKRPHSSLPPSYHRQIDLLHTIVSADPEALQQIVHNHPVALHSILISPTPMFNRNRSGCRPVIEIFAEGVKVWSSLKNYEELRSFELAEYPMVDLDLGNIVVDGDIQIIIYHARWIKMQHRVQLHFMFSVGFHSNFIRRNIRMLEFTRGDLDHQFSDDSKFGEPFRFSLLIVGIRLEINDIDHGFSLVGKLPAFIDFEWNNFSYSILVSDLSECELLMRNLGLSKQERTSPLSQQSNNISNTKCETKSSVESNVSNFFSTLDWTNESISNKADPYSMGNMKKNLPNISDQPLQSHTAEAYERLYGIRVSNIGDDDDSDQYKFDHEKVDNLKPSADKEKNNSASSENIDLLGLGSDLSSSAKTTPKVERRNYSRSHFDAINSIGGIFSANFIFDFYPVPGPKVKTGNDAFGDLLSSHGFSASSRNVKSIGEMKRENDVKDMDPIAVKIRDWTRGKERNIRALLSSLNDILWPGIDNWEQPSMADLLTPTQVKKYYRKACLVIHPDKQTGTENESLAREIFTELNDAWTSFEASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6J1</accession>
    <name>A0A0N4U6J1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6904</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6J1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6J1"/>
    <dbReference type="WBParaSite" id="DME_0000254401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000254401-mRNA-1"/>
        <property type="gene ID" value="DME_0000254401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000254401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41982" checksum="669F23090DD8DF17" modified="2016-06-08" version="2">MNLKRFNSSKIDLKNAYKLLNLTENATNEEIKRSFFELARKFHPDSIQNQGKSDDFIRIRNAYCLIVRSSQVKIEEEKETATFSDEIIGDIKHKPAQHRQYLEYGGIGRGNPYQRQKQYINHRALQALENVHEYLLDKTKYDKENEMATTSLQVTKEQEHYAKKQKTTNAIERMVEDMIVESMKRGDFNNLKGMGKPLAEQESNPYIDNVEFKINQILINNGFAPPWIMKNAEIQENIKLFRSKIRMEYAKYVVSRDGVSLTSNVLAQSKWNNITKEMEETVNAINKAVKDYNLLTPSVYRQLFTLSFVQEMNKAVADVQSENFNSKWIVKAREMLVKSTEKPDSKSGFFANIVQKFRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6N9</accession>
    <name>A0A0N4U6N9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6963</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6N9"/>
    <dbReference type="WBParaSite" id="DME_0000260301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000260301-mRNA-1"/>
        <property type="gene ID" value="DME_0000260301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869600at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000260301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18571" checksum="34639F5817B8A14C" modified="2015-12-09" version="1">MGCCLATLLDPAPPERVVKYFWHIKGIYVEVQNDVKNKFIRFAPGVIYVQNGFLWYKPRRLTSSRNKSTLQFDICKLENIIVRSNFISDHDPRKYSGPIVDIFVSDASNPTHIGIRSDKAESASQLRFLSLEGNSTLWDPYDADNYQAKRSYLNKLLRKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U750</accession>
    <name>A0A0N4U750_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS25</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U750"/>
    <dbReference type="STRING" id="318479.A0A0N4U750"/>
    <dbReference type="WBParaSite" id="DME_0000279601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000279601-mRNA-1"/>
        <property type="gene ID" value="DME_0000279601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778379at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000279601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14984" checksum="9BDFE8F2B855066A" modified="2015-12-09" version="1">MLSDTVRNTEQFGGSRKYIRRKSSSCWEIPTKEASKFAKIRNDDKGIEVEINLDSFPHFHPEDIDVCVTGYDLQIFAQKDNPNNPNYPSISLSRQYRLPDDIDLDSVKIVRPDRRASQIKVRADKVQLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Q8</accession>
    <name>A0A0N4U7Q8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7190</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Q8"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Q8"/>
    <dbReference type="WBParaSite" id="DME_0000303101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303101-mRNA-1"/>
        <property type="gene ID" value="DME_0000303101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977625at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22900" checksum="60D7C64E9EFB97E4" modified="2015-12-09" version="1">MNRILSSVKYFDKSKLLARNGNDIEQIRKVSVFLKKQSKIDPEQAKLRELRMRRKLEKEIRQLKLHSKKPKPIMELTIDIKSAKNIDERYRPKSVLFKISDDEMEKRYIALRDYSFSRAALMRLDEKWIRQSIEKQEKALKELKLLSLDLYEAAIQPDHSIDDGIILNGPTLTPPLTNYEPPDGDYIDITKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U808</accession>
    <name>A0A0N4U808_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Doublecortin-like and CAM kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7311</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U808"/>
    <dbReference type="STRING" id="318479.A0A0N4U808"/>
    <dbReference type="WBParaSite" id="DME_0000315201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000315201-mRNA-1"/>
        <property type="gene ID" value="DME_0000315201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="11">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="11">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="294"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000315201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="612" mass="69631" checksum="8A59FBF75E71989C" modified="2015-12-09" version="1">MVASTSTQAATSNAQTPSAPVPFRCFPTNKAKRVRFSVYKLQGIWYAISAERVRSFQALLGDLTRAMTDAVNLPHGVRHIFSMDGSQKINDLEEFTDGEGYVCSSSEIYKRVDYENAREPTWCNSLNGSASAVPLFFDSPIKQEPNDFVYPRIITIIRNGVKPRRIVRHLLNKRTARSYLQVIQDLTIIVKLDSGAIRKIFAISGKEVTCLADFFLEDDVFIAYGKERMGVDDFYVVSEETKRLYSSRGRKNRGTPRRRRMPARNESLRNDRVGCIVPDSEMSRHLPLVLDNLLHIVRLIGDGNTALVYEVLCKKSRSRLALKIISRENAIGKEDLIKSELSIMQRISHEFIVRMFDYWQFDGSYYLSLELITGGDLFEYLCHARRVEERTAASLLKCLASALDYLHSIHIAHRDVKPENLLVYNCSSTGNLLLKLADFGLAVELTGDPLLVICGTPTYVAPEVLAELGYDHKVDLWAAGVILYVLLCGFPPFQSVDGNQEQLFEQILSGQFNFPSPVWNNISYSAKGLIQGLLQLDVEERYSASQILEYPWIQARFNFHNSSGIIDEEYEKLMEVAVKVTAQKEARKNLLQESEFEYFFSRLIYHFAKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8G4</accession>
    <name>A0A0N4U8G4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7493</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8G4"/>
    <dbReference type="WBParaSite" id="DME_0000333401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000333401-mRNA-1"/>
        <property type="gene ID" value="DME_0000333401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000333401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16422" checksum="417101A54460D79E" modified="2015-12-09" version="1">MSAILDMVPASSGTYDSLVVYAISIQFERKATPRLINKICSQARCVSTLLADDRDKDKFYAELQPKYDMVIIGEEGRKDWNGRIGYNAAAMTTGKYGIGDRCANRGCAPRLLRFAEEHKFFVTNTYFRYRKKYLISRSPTLQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8I7</accession>
    <name>A0A0N4U8I7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">L-type lectin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS228</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8I7"/>
    <dbReference type="STRING" id="318479.A0A0N4U8I7"/>
    <dbReference type="WBParaSite" id="DME_0000336201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000336201-mRNA-1"/>
        <property type="gene ID" value="DME_0000336201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06902">
        <property type="entry name" value="lectin_ERGIC-53_ERGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000028">
        <property type="entry name" value="Blast:Protein ERGIC-53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229891" evidence="9">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000336201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54494" checksum="F2FE1D95F1DDE392" modified="2015-12-09" version="1">MDCIIEFLFILLATHFDEIAGQLPVHRRFEYKHSFRAPDLAQRDGSIPFWTIAGDAIASNEQLRVAPSMRSRKGIAWNKRPMIESENFVIEIALKISGQGRIGADGLAIWYTSQLGTIGPVFGANDYWTGMGLFLDSFDNDGQKNNPFVSVMLNDATRQYDHQSDGSQQILSGCQKDFRNKPYPVRLKVEYSLHVLTVYISDGLQPNARFELCIRAENIFLPQGGYFGLSAATGGLADDHDVIEFSVFSLFTDEQRPKKGALPQDIKQQYDAEFEQQMKEYEMEKFKEQHPDKVKDDEEDVAKYYEDTAQRELRLLYESQNAIYQVMQQMDNKLREIATCGTSAGQAPGGQPAGQVIAGGVGFLPHEKNEALQALRDLTSSIRDMKSYVNEIFTRTYNIDQKLRPPSGGHIDSSALHHSIESMHNDVREIRSAQITQVLCNYFHITFSIISFINFYFAIQYLFFIACRSQANLKKIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8S0</accession>
    <name>A0A0N4U8S0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoprotein endo-alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS322</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8S0"/>
    <dbReference type="STRING" id="318479.A0A0N4U8S0"/>
    <dbReference type="WBParaSite" id="DME_0000345601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000345601-mRNA-1"/>
        <property type="gene ID" value="DME_0000345601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11574">
        <property type="entry name" value="GH99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000019">
        <property type="entry name" value="glycoprotein endo-alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF4">
        <property type="entry name" value="RE57134P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000345601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46641" checksum="4734A51C2D7D99D4" modified="2015-12-09" version="1">SASISTEPFLDEQQFQGKDITTTSEHNRVIEKISNIKFQRITESSVHIFYYPWYGNPEFDKKFFHWNHAYLPHWDKVIAKKFIQGIHVPPEDIGSNFYPLLGPYSSRDPSVIEQHMKWISSANINVLVVSWYPQHLADVRGHPWDDIIPILLDMANKYSLKITFHMEPYKNRTATNLRRDIEYLLDFYGTHAAFYRYFRKNADGSLAVLPLFYFYDSYLIELTEWLKVTAKDGELSVRGTNYDILFIGLVVKSEDRYWLSDAGFDGMYTYFATEGFTFGSTATNWPSLNVFCRKKNLIFIPSVGPGYDDRRVRPWNSQNTRSRLNGHYYSKMFKMAYNSGADIISITSFNEWHEGTQIEPAIPFTDSNAEFTYNVYNRGPYQYLQLTANLVKQFFTVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9B8</accession>
    <name>A0A0N4U9B8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7674</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9B8"/>
    <dbReference type="WBParaSite" id="DME_0000366901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000366901-mRNA-1"/>
        <property type="gene ID" value="DME_0000366901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000366901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9446" checksum="3FCC3E76F7156C84" modified="2015-12-09" version="1">MGIMITSARCSIMQSFFNATRCVRTPMIPYNACRFLSTNKDDIVVTERLSDAKGKRAACLAKIYLIYLKMQIMRELLVMKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9E8</accession>
    <name>A0A0N4U9E8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9E8"/>
    <dbReference type="WBParaSite" id="DME_0000370501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000370501-mRNA-1"/>
        <property type="gene ID" value="DME_0000370501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000370501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15722" checksum="003F4EEBB1617F71" modified="2015-12-09" version="1">MLTPTDKMVRRLQATRSDAIVDSNRSHSFFHRLSTYITGPPIRSKSFIFSDRISSGLEWPSLLTLHDLASNEICGNTCGGRQRTFSNHRRRCFAIILLMQVVFERGWWMRSCDTLSARRVKLSFLRQQWSKQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9R1</accession>
    <name>A0A0N4U9R1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7845</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9R1"/>
    <dbReference type="STRING" id="318479.A0A0N4U9R1"/>
    <dbReference type="WBParaSite" id="DME_0000384001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384001-mRNA-1"/>
        <property type="gene ID" value="DME_0000384001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10599309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18534" checksum="06C5B6F8FF9C8913" modified="2015-12-09" version="1">MKDEKSFGNTGLLQPAKVNYKTLEECSYDDPCIFSNIANEQEMSPYETKSETEQWTSKAITNRLAVIIILLLMVIQTIFGFLSSSLACITDVFRLSSDYLGQHRISEKNSASLRRLAYQPRRYVALGDFIDIKIRQLIHLIGNHGVSLIFVLEAIIINIQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA73</accession>
    <name>A0A0N4UA73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THF_DHG_CYH_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS394</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA73"/>
    <dbReference type="STRING" id="318479.A0A0N4UA73"/>
    <dbReference type="WBParaSite" id="DME_0000403001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000403001-mRNA-1"/>
        <property type="gene ID" value="DME_0000403001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000403001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11419" checksum="05985A387FF2319E" modified="2015-12-09" version="1">MIPRRKNLAIVNVPQTTRYLNWSGPFLQICRTEQSRKRFPLLHTKVGPMIVGNVDMNQLCQAGTTHTSDTICVVTLSSGSEIKKNLNVSEFLFNDKEFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAH7</accession>
    <name>A0A0N4UAH7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS8036</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAH7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAH7"/>
    <dbReference type="WBParaSite" id="DME_0000415301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000415301-mRNA-1"/>
        <property type="gene ID" value="DME_0000415301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="136"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="344"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN58063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000415301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60992" checksum="B04B4E46479F52E4" modified="2015-12-09" version="1">MHRNALLKQILHVEGDENEDFIKRKRQKKEEERRAEEAKKSLLEKHNELTENINGISTFFLYLIIVNFSWHPPRHILAMKEEEHVTTRRKKGIVVDGEDIPPPIGSFIEMKFPPSIIQALREKKIICPTVIQMQGIPVVLSGRDMIGIASTGSGKTLTFALPLIMFCLEQQVSLPFRHGEGPYGLIIVPSRELAKQIYDVIDQICEAIASSKFPRLRLGLSIGGLPIGDQVRVFERGVHICVATPGRLSDLLNKKIFNLQVCRYLVLDEADRMLDMGFEDELRTIFSFFKGQRQTLLFSATMPRKIQNFARSALVKAIIVNVGRAGAASLNVTQEIEYVRSDEKLTKILECLQKTPPRVLIFAEKKSDVDSIYEYLLIKGVDAASLHGGKDQKDRHTGVDAFRRGEKDVLVATDVASKGLDFENIQHVINFDMPEDIENYVHRIGRTGRSGKKGMATTFINRKADISVLQDLRALLLEAGQELPLFLRDIAGDGNELRQDNLAEEQDKGCAYCSGLGHRITECPKLENVAAHIGRLDYGADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAZ3</accession>
    <name>A0A0N4UAZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8233</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAZ3"/>
    <dbReference type="WBParaSite" id="DME_0000435001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000435001-mRNA-1"/>
        <property type="gene ID" value="DME_0000435001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000435001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22926" checksum="134F5DC1D41A9BA6" modified="2015-12-09" version="1">MEALRRAAFIVLLRFVSDDYPLLRLEVIWIIISRIALIRVKFLRGGHLRIISRAIDKNLNAKVTSGSNFSLLELMAFLEEQRFFNTQSSSSNNNSSRPQSISLGIRPNTINSSSKTAQSRFSTNEPIQPASPSFSDLQGDRTSLKLSSNIFENVKESFDVKYESQIFFIYYCCIMVRKRISFVHMSIMYECMNIETKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB43</accession>
    <name>A0A0N4UB43_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8286</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB43"/>
    <dbReference type="STRING" id="318479.A0A0N4UB43"/>
    <dbReference type="WBParaSite" id="DME_0000440301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000440301-mRNA-1"/>
        <property type="gene ID" value="DME_0000440301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF105">
        <property type="entry name" value="DLIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000440301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12474" checksum="63905E4E84E2C6EA" modified="2015-12-09" version="1">MAICGGCNTAILDRYVFHVLDKTWHASCIRCADCKELLTETCFSRDDLILCRKDFSRRFGTRCAGCNMALDRNDLVRRARDKIFHVQCFQCTICQKKLDTGEQVIRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB66</accession>
    <name>A0A0N4UB66_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8312</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB66"/>
    <dbReference type="STRING" id="318479.A0A0N4UB66"/>
    <dbReference type="WBParaSite" id="DME_0000442901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000442901-mRNA-1"/>
        <property type="gene ID" value="DME_0000442901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000442901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20054" checksum="BCE8109CA811C81F" modified="2015-12-09" version="1">MKSPEQKSNLMESSLKRLMDVRLKLFRNIAKEVVGIDQNLYNKPISFALQEYIEAWSFYKFISSGKLLSIDEITESLKFEERVCDDETGNHFQLFIEVSSMDYLLGLSDIGGELMRFAINQASAGEHNVAIDVQKFMCFLYGYFIFLGNAINNRDWQKKLEVFHQSLTKINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBW9</accession>
    <name>A0A0N4UBW9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Apyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8610</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBW9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBW9"/>
    <dbReference type="WBParaSite" id="DME_0000472701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472701-mRNA-1"/>
        <property type="gene ID" value="DME_0000472701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25028at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32255" checksum="988CDE568775368F" modified="2015-12-09" version="1">MKLHDGSSIYQIVIVTDLDQNSKKENNLWLSFMKHGTLTINSDWTKASIQWHDGDEVILKSSLSVGDRSMELSDLVVYLSDGSGNESKPFKGEWLTVKDSELWAGGLGKEWTTSEGIFVSFNPMWVKKINPNGCVQHINWVEPYQKLRSSVGIEYPGYMIHESAQWSDIHQKWFFLPRRVSQFIYNEMEDEERGSNYLLVASQDFSQVDYRQIGNFTGSRGFSAFQFVPETNDRLIIALKSEEKGGKPVASYVTLFNIESDNILLNEEKLEGSYKYEGIAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD03</accession>
    <name>A0A0N4UD03_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8973</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN59000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD03"/>
    <dbReference type="STRING" id="318479.A0A0N4UD03"/>
    <dbReference type="WBParaSite" id="DME_0000517401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000517401-mRNA-1"/>
        <property type="gene ID" value="DME_0000517401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034330">
        <property type="term" value="P:cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000517401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23520" checksum="8D3392CEC1521F9D" modified="2015-12-09" version="1">MSFNTRPIILSGPSGGGKSTILKKAMENYPDRFAFSSVLDTTRAPRIGEQNGIHYWFIDKASFEKMIANEEFIEYAVFSGNFYGTSKKAIEAVQKTGRICVLDVELNGVKNIRKFGLNAKYILIRAPDLQIIEDRLRQRKTETEETLQKRLNQAKEDLDAVCAQPDLFDFIIVNDDLQRAYEEFVDIIKEELEQFGPSQRQIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD58</accession>
    <name>A0A0N4UD58_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9043</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD58"/>
    <dbReference type="WBParaSite" id="DME_0000524401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000524401-mRNA-1"/>
        <property type="gene ID" value="DME_0000524401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5827163at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039186" evidence="4">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000524401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15159" checksum="C3639DF518605687" modified="2015-12-09" version="1">MLAVVILLILTIHAQKSIAITCYKCSSDGGEDCLSRSTSCSYGFFGCIKTVTYSGGLDKMGNNEPNLEKRIISMNRDCTILPITGVDICRQVSFLGYRLQTCYCFNDFCNCASLRTLLFSFLFIVIFHIFYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDI3</accession>
    <name>A0A0N4UDI3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9197</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDI3"/>
    <dbReference type="WBParaSite" id="DME_0000539801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000539801-mRNA-1"/>
        <property type="gene ID" value="DME_0000539801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="442"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="528"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000539801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="657" mass="74649" checksum="5632BDDE2EC723D4" modified="2015-12-09" version="1">MSADEAGTSRKRSSSQLIIHGDQISGEASRQNDEYEESRNDEPQVKRFLPLSLSSGLRNLIEPESERATPLDSSFIANDTSNSLQTDSKTLTCRVCISAHLENHSLCPICRKNLLKSSKLLISPNITVAEATETLRAQIEISRKYGKNRPTRLYDDNGNLNELLNQLNNLDSESLDHVISFLNKRRLEIGYLNKKKKARLLRQFMDQMIARRENIIKQAELELKLIKSDKIKMEMNTNFLDCNLCDKYACHSSAMASYSAFTKIKGDNLSVTDGDGLLSREDLHRFHSRLSNNFSNIEQLYFNKRNNDWSNSDGMCEADLNDFSDMLYGVIEYEKFNRLAVLDYNSCLVGNPLSIVSSIEFDKDEEYFVVAGVTNKINIYDYNSIVEVSHESIRHPIMQLTCPSKISNVAWNPFIKSMLVNSDYEGNIHIWDTKQCKDVKFYKEHQRRCWSVEFNQIDPHIMASGSDDAKVKLWSLNCSRSIATIEAKVNVCSVHFSPMSRHNLAFGSADHCVHLYDTRNISKAVNILRGHRKAVSYVKYCNENELVSASTDSNLRLWDVSSGKCIRIMKGHQNERNFAGLATNGRHIACGSEDNQLFLYYKGLTDPILRYDFSFAECVPLSVDSANDFVSAVCWKKKSNVIVAANSRGIIQILEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDQ3</accession>
    <name>A0A0N4UDQ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS580</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDQ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDQ3"/>
    <dbReference type="WBParaSite" id="DME_0000547401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000547401-mRNA-1"/>
        <property type="gene ID" value="DME_0000547401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="188511at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="392"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="569"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="783"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000547401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1050" mass="116942" checksum="034B2A65EB270A34" modified="2015-12-09" version="1">MVLKFKSHSWLGIGWKPQGATCSPFHQPEESNQIDNALRFSSTAIENPIEQQCVSNEIFSVCPEFNRQCEASCDWTKFPETIPNCPHSCGAPKCICKEGFVRLSTDNDTCVPFHFCSDEAQTECFVNSTWAKCGIACEPTCENMYDTSPCPAFCDQPACTCADNYVRHNGTCIFWGDCPNLEEHWMTGEPTSITTFNRVSTAQQEATVKADVITNPAIAVEELTCGINETINECGRACEPDCISVFIRDKCELCASASCTCLEGYARNEDKCIYWGDCPFEASGLQTATPIKILSVTRSAVSLEEALIAPMVPTAATLFDEPLITNISNSTERTIVHILATKSVTAINQVFSSNAVPVFPTVQASKSIDHKTGVVGDVCYGDWRWPTGCRDCDYRISWNYIDDTDEIEFSVETRAPSNWWTGVGFSPTGTMVEADMIIIKSRNGELTLHDMYSTQNGVLREDSEQNIYTPTVVGTHVNGMLRGQFMRKRDTGDKKADHRFSDTNCYKFLFPVSGGRLDANGQLMKHISPPQVSERKVCIKSCTQPQTLQPTSSCETEFRYPTGCEGSACDYVAKWEYSMARKDVHFEISSKELGRWTGIGFSRDGSMANSDIYTGWVYEGKAYVTDRFAYGRQLPAIDPADRQDIYEISGKAEDDIQTISFRRKVLPADTLTDFPLNKCYYFLFPIGGGRVLARKSPDFQNPKTPIGYHDLYQPRVSRTKICICDQNGVSIASEDASPAIRSRRQVQDPFELQIDPFVEAQGDANISDLQATTREATDSSNSIDNSLMYQSQFVTDNEFEVNVNSVMESSPKPSMNEINFVPKDVNKAPGNAMDCTDMVIGSVVNGLTRIKDYYTMSNSIPRLDSFYDGQDSLTSAAAYEDEEYTTIVFRKYLICNNSPDEISDQPISNGTLTFIWAKGSHKSNYISRIDESLKDNNSSDKLFFQSDVINYHGINNRGVFTINLFDNGLKSENSHDFDCSGSFSYPSGCEIVDECSYTVHWIANGGRISFNLKVLMNASRWTGIGFSLDGTIIKSNFVIISVLEIARDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE14</accession>
    <name>A0A0N4UE14_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bardet-Biedl syndrome 5 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS639</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE14"/>
    <dbReference type="STRING" id="318479.A0A0N4UE14"/>
    <dbReference type="WBParaSite" id="DME_0000559401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000559401-mRNA-1"/>
        <property type="gene ID" value="DME_0000559401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000559401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42176" checksum="0734B0ECC6BB066A" modified="2016-06-08" version="2">MNSRRREAIADIIWQHREIRFDLDPRHLRLIHGEHIIDRIDGVEDTKGNSGDKGIFRITNLRIIWHAVQMPRINLSIGYNCINGVTTRIAESKIRGRAESLYIMARNANTRFEFIFTSISPSQTKLFTSVISVHRAYETSKMFRELRMRGALINEDGQLRILPQEQQCDRFEGIWNLSGDQGTLGVLILTNIRIVWFSLVNPMYNVSIPYLHLQCCRIRDSKFGVALVFETSVTSGEYVLGFRVDPKDKLQQICKSIQVLQNAFISKPIFGVQYGRERPVIAFSPLLLILDINQQTGTPKAIGETLKLIDEDIELDERPLRSDAFAAYFSDGLISEGVRPPVYSEELGIAIEQLKPGFTISDLWNIHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE56</accession>
    <name>A0A0N4UE56_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat (TPR)-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS687</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE56"/>
    <dbReference type="WBParaSite" id="DME_0000564201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000564201-mRNA-1"/>
        <property type="gene ID" value="DME_0000564201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000564201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23221" checksum="5EF5FACA6C72DDE3" modified="2015-12-09" version="1">MKFSAAAALTQISWAVLLGVEIALKGSKEYQEVWHALKIDPIHPSLNVAYSVVVGCAIASVCMCDLMNVLLNFEKSLSLEGKKEKAEALYGILPIVLNILQQALRKAKLNEEIDGLLMIEEIWNLVDNPKGMDCLNSCADNIIPFMQLIVSRNTEDDKFRKDSLQNMVTDQAIRAQASFASQQSSSQLFKDKHEYISLTMPNVSKQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEG5</accession>
    <name>A0A0N4UEG5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9364</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UEG5"/>
    <dbReference type="WBParaSite" id="DME_0000577101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000577101-mRNA-1"/>
        <property type="gene ID" value="DME_0000577101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000577101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12444" checksum="96968446048312F3" modified="2015-12-09" version="1">MLAKIVKEHNSAQQIHKELQGEESSILYSLNVFQKRKNEAIVAAQNFSNAIIDHLNYSISRAYNNQKRLDVEAKKLENNAMVLVKQTGKWVQLTDQLNQALKVINASYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEJ9</accession>
    <name>A0A0N4UEJ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS803</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UEJ9"/>
    <dbReference type="WBParaSite" id="DME_0000580901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000580901-mRNA-1"/>
        <property type="gene ID" value="DME_0000580901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="61"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="347"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000580901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53383" checksum="36AB3A3B064BF44F" modified="2015-12-09" version="1">MTKHGTIIQEVGKYPTVISGIVILYNISIASAPNGEETNTPEGLNTELMPHQKQGLTWLLWREKQSFSGGILADDMGLGKTLSMVSLIVHQKNEGTKIRKNFEIVENSGEKQNRMLFYHATLVITPASLLFQWEAEIKKHVKPGFLSVLIFHGSKQKRECDPKRYCFSIAQFDVVLTTYGLIISEIGEKKKRKDHDDNSSYSSLNSHIFFYFQRLQSSLMKIAWERIILDEAHQIRNKMSSISKACCKLMGHSRWCITGTPLQNKLWDLFPLIRFLRISPFDEEVIWKEWIMTSRKRITVAIFWTISIVVNNDDAVRFFEFFITGGVRKIVDGKFQAMGCMFVLLLRLRQACVHFALIKEVIVIVSQWTSLLKVVEYHLKLRSIDFTSITGKVLPEERNARVKSFNEIKSGPSVMLLSLTAGAVGLNLVGGNHLFLTDLHWNPALEQQACDRIYRMGQIKNVFIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UET9</accession>
    <name>A0A0N4UET9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GuKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS853</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UET9"/>
    <dbReference type="STRING" id="318479.A0A0N4UET9"/>
    <dbReference type="WBParaSite" id="DME_0000591401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000591401-mRNA-1"/>
        <property type="gene ID" value="DME_0000591401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="Guanylate kinase/L-type calcium channel beta subunit" evidence="11">
        <location>
            <begin position="194"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000591401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52484" checksum="E5D0784EA77DA603" modified="2016-06-08" version="2">MTSFGSGDSNYSHHESDFDLEESNRESLRRDAERSAALQLERAKYKPVAFAVCTNVDYDGSIDDDSPVHGCAVSFKVKDFLHIKEKFNNDWWIGRLVKEGHDLGFIPSPVKLESIRQQSAKGSKFKQSSSGSNLGTLDDMIRRSGSRGSTPPTPKYGHGKKVADMVTTPPPSKEKKKLMFKKQENVPPYAVVPSMRPVVIVGPSLKGYDVTDMMQKAVFDYLKHRFEGRIIITRVTADISLAKRTLLNNPSKRATMERANSRSSNSLVEIQAEIERIFELARSMQLVVLDCDTINHPSQLTKTSLAPIHVYIKISSPKVLQRLIKSRNKSQTRNMNVQMVAAEKLAQCPSEMFDVLLDENQLEDACEHLADYLESYWRATHPPVKSPPRIKRNPMENRGPTTIFTPMQYDESVPIQNMVSHPSGSLPLQNMQRIPPSSQQQSHIMQQDQQGFDEYDDDNFQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFB7</accession>
    <name>A0A0N4UFB7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1057</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFB7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFB7"/>
    <dbReference type="WBParaSite" id="DME_0000611801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000611801-mRNA-1"/>
        <property type="gene ID" value="DME_0000611801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase C-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000611801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14967" checksum="D8A9BC2DA06D22D0" modified="2015-12-09" version="1">MQILEDIGIEDASVADCVHVAYVCSLVSKRAAYLCAAGIATILKRMSKPYVTIGVDGSLYRFHPKVPRLIDRKIDELLPPDLEYQLMLSADGSGRGAALVAAVATRIKQELQNTLLHEVPSIPGSVEVVDGDALEFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG19</accession>
    <name>A0A0N4UG19_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9523</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG19"/>
    <dbReference type="STRING" id="318479.A0A0N4UG19"/>
    <dbReference type="WBParaSite" id="DME_0000641201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000641201-mRNA-1"/>
        <property type="gene ID" value="DME_0000641201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106279">
        <property type="term" value="P:negative regulation of UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000023">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="74"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000641201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="43759" checksum="DC0720F41E203BC8" modified="2015-12-09" version="1">MKKIRYDCEILRENLRETLIQFVNCRLINILENYYSIVENGEIWIKNGRIIDGKKIFYDEKCNADLQVDCCGLIIAPGFIDIQINGGFGTDFSSVAAEDFVEKVEEFSQSILRYGCTAYCPTFISSRPEIYHKVRAHLEGPFIAKTKKGAHPEANICEDFGDDPVLTIKSVYGSLENVSIVTVAPELNGVEKAIEFLKRKNIVVSLGHTNAHLEDGLAGLHAGATALTHLFNAMRPLHHRDPGIIGLITMKHSSPLYFGIISDGIHCDEAILRIAHSVHPDGLILITDAIAAFGMGDGIHRLGDQKVRCKGMKATVDGTNTIAGSIASMDHCVRYFKKVTGCSLAEAIYCATARPARLLGIEKERGSLSFGCFADLILIDDDISVHATFVGAKLSYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG91</accession>
    <name>A0A0N4UG91_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9607</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG91"/>
    <dbReference type="STRING" id="318479.A0A0N4UG91"/>
    <dbReference type="WBParaSite" id="DME_0000649601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000649601-mRNA-1"/>
        <property type="gene ID" value="DME_0000649601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000649601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14133" checksum="06CFBDD4D965DBC9" modified="2015-12-09" version="1">MGGRCSKGASSPTHPQFSDFSVYRSIGRGTFGRVCIVQYRSNKKLYAMKYMDKRRCVQRMAANMVLRELDLLAHLSHPFIVNLWFSFQHHSDFLMAIYTPRALLEGKLVIFDTLRISKFSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI14</accession>
    <name>A0A0N4UI14_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clathrin_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9894</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI14"/>
    <dbReference type="STRING" id="318479.A0A0N4UI14"/>
    <dbReference type="WBParaSite" id="DME_0000722601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000722601-mRNA-1"/>
        <property type="gene ID" value="DME_0000722601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917212at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046359">
        <property type="entry name" value="Aftin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156">
        <property type="entry name" value="AFTIPHILIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156:SF10">
        <property type="entry name" value="AFTIPHILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000722601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67023" checksum="896785449E560ACD" modified="2016-06-08" version="2">MFNGPPPLPLPSASDTINDCGLTDLDDSSRLTAVDGDDLFLERSKNFQLIRVDLPDFQEVIGELNTDSSIFSDEVVRNFPKGQQNSGEKKLVRTMNSSINNDIPVNCSKKQLKIVIASSSENDQQKETNKNYITEVSNLCDNKEISSMSDCYFTSEVRKISENSENSNKSEENKISNWRDKSDVEEQKRKELEAVQIVHTGNSVLQTYAIEQVERNSGEYVDGSDEFGDFETFGDFASCSHENGNQENEEKMNEAVERDWLRNETKTELRNDWVADFDMDFDNDKSSVRKEGTDLNNSAQRLGTDDSDLELDHEDLPELSKILGISLWDVEENSDEENEISYNLSGIVENLDAINPAATSIRYWFILNGIAIGKSLKHFISHFIAFSEFHRLFNIEFQYLAISRNMNLPAFAQQLGDQEVLRPMVAIDASEKRLNKDDGSPNSRSPELRQRFSTSVVVDSLAVPPAQFDWGDSGLTNPLTSSSISATSTFLDLDFLGNVNSTTPSSDCISSALQKDLAVFGLGSYISDNSSVEISTRPDGDDAKKPNILEELMRQSNTERRYTSPNELSLDARALHDQLPDLDYMLADVLLFPLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI37</accession>
    <name>A0A0N4UI37_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9919</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI37"/>
    <dbReference type="WBParaSite" id="DME_0000725101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000725101-mRNA-1"/>
        <property type="gene ID" value="DME_0000725101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000725101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10221" checksum="9C7669B45911EE65" modified="2015-12-09" version="1">MFISKFQHGRRPAPPPPPPPPPPSTTRPPTTTTTTTTTTTTTTTITTTLPTTTAIEEFDDTIFISESSNGVCDMDWMELAKRLQEAFGKVHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIF0</accession>
    <name>A0A0N4UIF0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1742</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIF0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIF0"/>
    <dbReference type="WBParaSite" id="DME_0000738001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000738001-mRNA-1"/>
        <property type="gene ID" value="DME_0000738001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="61"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000738001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32532" checksum="700893B1E66245B6" modified="2015-12-09" version="1">CIQKKVFRQRDKYEIRPRVNNDEWILVVKNVQESDIGGYSCQLNTDPVMSRIGYLHLRVPPYVARTTASAVEVREGHNVTLSCRAFGNPPPTVVWRRQDRQIIRFNGATGYGASVYNGSDLVITKVSRKHMSEYVCVASNGIPPDESWTVKLHVTFEPTVVPQSKLVVAAAGSQANIVCNVEAWPRPLLTWQKDGNEIFDSNKYAMTQQIWEKYRSTHILTIKDISVHEFGVYKCIAVNDNGMHFAEITLKGSVFTGAFEIFPTKNLQTVQPLLTTIKSISIPFPSSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIG8</accession>
    <name>A0A0N4UIG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10039</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIG8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIG8"/>
    <dbReference type="WBParaSite" id="DME_0000740101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000740101-mRNA-1"/>
        <property type="gene ID" value="DME_0000740101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8655982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000028">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF5">
        <property type="entry name" value="CELL JUNCTION PROTEIN VAB-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000740101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23525" checksum="A242E62E66D67BD0" modified="2015-12-09" version="1">MTTRTTTIETVTIVRPLKVIALICLFIAFILLIVCISTTWWLRSGSFRIGLFLECTSSDERLQGIADGPPPGKCQKPHRYSTYIKAVAVLLIIAAVITILAFILNLIGIKTRDLHRKYVFYKIVTYFALLVVLLELISLIIFPVCFYVEMKNFGNRVWEFDWSYGIAWGATLFTFGATLLLICDKEHEEIYYKEKTIYNPPPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKG0</accession>
    <name>A0A0N4UKG0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coatomer subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKG0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKG0"/>
    <dbReference type="WBParaSite" id="DME_0000819901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000819901-mRNA-1"/>
        <property type="gene ID" value="DME_0000819901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5901798at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="1">
        <location>
            <begin position="35"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000819901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19121" checksum="D57AB22B19555868" modified="2015-12-09" version="1">MDRNNSKDGCVSAHMLQLLYAYLVNGNMELIDTCLRDLRNSVEKSESNNHQIQFKLAKILGGIGEKGSTTAHYAKNLLDNAIQLWRKSEYLAEKVQRLMHYDDFKTAKPLAIEALQIDSQPEPQILLGIVRCFLAENQIEDALAQLEFVRVTHPAISQSSAIVLLFVSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKG5</accession>
    <name>A0A0N4UKG5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKG5"/>
    <dbReference type="WBParaSite" id="DME_0000820401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000820401-mRNA-1"/>
        <property type="gene ID" value="DME_0000820401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856214at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
        <property type="entry name" value="FRRS1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000820401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12408" checksum="823B589336E9BB11" modified="2015-12-09" version="1">MSLPITIDLSSCGTKKGCLAIPYGCQNNSQLQCSSIFTYQVDGDYLLMELLGLVDDIERSYVAIGFSLDQYMGNDSVTECSVAPGSPLQGRLSYNKGTMNYRVNISDVISLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKK0</accession>
    <name>A0A0N4UKK0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS2300</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKK0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKK0"/>
    <dbReference type="WBParaSite" id="DME_0000827001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000827001-mRNA-1"/>
        <property type="gene ID" value="DME_0000827001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2107370at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000064">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="353"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="1074"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN52327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000827001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1275" mass="144905" checksum="607FC89E9C5BE43A" modified="2016-06-08" version="2">MRNEEDNQEESMDMLSEHRENQSTPVANGSNSYRAAVQMFRKFSFDDLYSGRTKKTRSNSPRRIPLFERASTRWWNPQFASPALESQYWKCSFPQLKDRFRSGLLYVILTCILWITYLYAFDQVDSFHWVTTCGLVLISSGMMLFTLFTIQYQRFYMPTSFLCVFILSIVTLLIFSDMSDSFMSPIGALNTSFQVVLLIYTVIPLPLYLCILIGVIYSALFELLSSSNIHYGDILGMKLVLHLGIHLLGVHLFILTQVRQRKTFLKVGQSLLARKDLEMETQFKDHMIQSVMPKKVADELLKETNVRRSSVNQEAYLRATDNKNRSTGDRNYSVVPNVRKFRPFTMNLMTNVSILFADIAGFTKMASNKSADELVNLLNDLFGRFDYLCGKCCLEKISTLGDCYYCVAGCPEARPDHARCCVEMGLAMIIAIKQFDIDRGQEVNMRVGIHTGKVMCGMVGLKRFKFDVFSNDVTLANEMESTGIAGRVHISEATAKFLNNEYILEEGKPHGGYFELIKMRMKTYFIAGRIKETDSSSKTASCSISARDGAAVDTFLNRSQISFKKRLTNKLKMVQTNSLPTERYAGSLRMKLLEKKEECNSVQILHHSESLDKNGQSQLVERRKSASLQALPVAESKPFCIAEKIGGRISRDLVNACNSSACNSGPGSKSSGLQESFSDAYSVGGAIDTIISHHQNAPSLTHFDTENRDFDERLAQNAGMNFARGFWMQDDSLNRWSLRFNDLDIENRYRAHFADFADRQWTKKETEGRRKNQTAVDAEESSTQYRYSGVFIDMLVAGVLLIICAGVTFLTGKFHMAFVMYFCVSFIAVVIMIITIGIPLLRRRIIFPCVNLWTPRHVIGMILMLLPVGIALSIIPQYGKTNNLSCINAELFLQRITFSYVFLIALFAHCNFSQLSAWPKTTQATFVGILFIILTFVNQYQEIDLLAQNMTGMSNINSNSSTILAILPIMSELQYVCNVSLPKWAFQGAQTPICIWEIILDIFLGVVLVAFLNYQFEAAFRMSFFGDVQARMDTEKMQSVRDQADWLLTNIIPQHAIDSLKSSTKYSENHSMTAVLFATITNWNEMYEETFEGGREFLRVLNEIISDFDELLDRPDFSQVEKIKTIGATYMAASGLNPERRRLALHPYEHLYQLIEFALALQQQLNFFNQDLLNFDFVCKIGFNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVQNRIQVPQQTRDLLCDRYDFEYRDHIEVKGIDSGMDTYLLVGRKGEPPINFSNSPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKQ5</accession>
    <name>A0A0N4UKQ5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10350</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKQ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKQ5"/>
    <dbReference type="WBParaSite" id="DME_0000833301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000833301-mRNA-1"/>
        <property type="gene ID" value="DME_0000833301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13113">
        <property type="entry name" value="Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF114">
        <property type="entry name" value="PROTEIN MOM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000833301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39565" checksum="6E447C3F0955A832" modified="2015-12-09" version="1">MWTHDLRTIRNNKHFRLLPYTSNISFQNNDAACKFLPSLTRKQRMLCIRNPYVIEQIISGLKSATKECQNQFKHNLWNCSIVEKEFLTTQIKIATRETAYIFALSSATVSRTIARACSEGKIASCSCGQQPRRMSKQFIWAGCSHNVNYANHFVRKFFDAVELENANDARSMMNLHNNRVGREILKKNMRRECKCHGISGSCVMKTCWKVVAELERLAAVLKRKYANAAKIKAVTDGDSLILKTERRSTGRTGRFLEYSRKLPNKNELVFLDDSPDYCIVDESKGVRGTQNRECGQKCEKICCGRGYRIVRSTVHEQCNCKFIWCCEVRCDICKKIVFHNFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL64</accession>
    <name>A0A0N4UL64_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10388</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL64"/>
    <dbReference type="STRING" id="318479.A0A0N4UL64"/>
    <dbReference type="WBParaSite" id="DME_0000852101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000852101-mRNA-1"/>
        <property type="gene ID" value="DME_0000852101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826793at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000852101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27944" checksum="B609AACB8B4F1DC0" modified="2015-12-09" version="1">NIEFADDEAKKAIKDAIQLWEHSTCLNFIENGEGENKIRFFSGDGCFSNIGRIKSNPEQAISIGEGCEWIGIAAHEIGHALGLFHQHSRSDRDKYLEIHFNNVKQSFAGNFHRVYKQLKYNAFAINESVPVITTKNKEYQNAMGQRLFPSFSDILVINKLYECFDECSNKDFETDCKHGGFMKPKQCEKCICPLGFGGAECDKVAPTYNRQRRCGGTLTAIFCSIFLIFSETNANAFMKKLPKSSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL81</accession>
    <name>A0A0N4UL81_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2497</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000064">
        <property type="protein sequence ID" value="VDN52524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL81"/>
    <dbReference type="WBParaSite" id="DME_0000854101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000854101-mRNA-1"/>
        <property type="gene ID" value="DME_0000854101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820108at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231542" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000854101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14471" checksum="A7763EB5CD96958D" modified="2015-12-09" version="1">MVLYLFIFVISGQLNVVQSDTREIFDEKENDFTKKALPFSGGIYGKRQVHVPFSGGLYGKRKADSFGSKKSQMIPFSGGFYGKRAMLYDDFDDIYDSAIYDENFKRTLRSNNRVNLRSLPMSGGFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL83</accession>
    <name>A0A0N4UL83_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS2500</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000064">
        <property type="protein sequence ID" value="VDN52527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A0N4UL83"/>
    <dbReference type="WBParaSite" id="DME_0000854401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000854401-mRNA-1"/>
        <property type="gene ID" value="DME_0000854401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051235">
        <property type="term" value="P:maintenance of location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008090">
        <property type="term" value="P:retrograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000002">
        <property type="entry name" value="cytoplasmic dynein 1 heavy chain 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1868"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2173"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2548"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2887"/>
            <end position="3057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1205"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3175"/>
            <end position="3220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3369"/>
            <end position="3431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN52527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000854401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3882" mass="444990" checksum="0EAD006CFFF89879" modified="2016-06-08" version="2">MTDSESDKSTVINSNNQAPNEVILIDLSVLINYIKQIFVGAINEQLEDFLKQTSSIESFQKFISDPQILILIIDRIIVRDTNPDDSNDEISIIFRVSNEIVKRAERTTSILLLKTGSIIEADKPVEDQLYSLRIPENNAYDVLLSIFGKIGTRLFKSLVDYGRGERDGDKLALSVEKHLSEVEVALLHMQQNIDIPEINLAINPVIQSTIQQAAEQGRKARVSDLGDLVESSVFLNALQKGVNRWVKEIQKVTKLDRDAGSGTSLQEMTFWLNLERALHKIAQKRESDEVILTLEALKCGKRFHATVSFDADTGLKQAMAMVNDYNILMKDLPLNELMAATHMDAIRNALINIFTHMKKLRNTKYPIARALRFVEAISKDVFTQMLKVLGTRRLMNIPLGDFDALMTQCFSVFSTWNDEYDKLATLMRDLSKKKRDEQLKLTWRINPQHKKLESRLDQMRQFRRQHEQLRTVISRVLRPSGLNAEDKPSHDAAGAGDAEKMLALNVGDSSAIDQINMAYENVKEVDCLDVSNDGVAAWEAALRRYEDQIDRVETQITARLRDQLGGAKKADDMFAIFQRFNALFVRPHIRGAIREYQTQLIQRVKEDIDQLQTRFTNFSETDNARILKSIDIPPVAASIIWIRQIDRKLTHYMKRIEDVLGRGWENHVEGRQLKLEGDNFRQKLNAQNIFEEWVGRVQSKNISLAGRIFNIEKRQKDGKISLKLKVNFSPDVVTLFKEVRNLKHMGFRIPLKIVNTAHQANILYPFAISLLESIRTYDSINERIAGNDGINMLIASYKKDIQNQLAEGNMLIWESYKMDPYVVKLSQSINIYQEKVEELDLLMTRIEVDLAALDTCQYSSVTFASLLASIQKAVDQLSLGNFSNLHHWVENIDKKIELKLASRVEAAILLWTTVLTHEEMDDENEEKIVLPAVQPVLLEMRVTSQVLYVSPNIEQARAQLLDQLFSWQSIITNQSRISSTRFQLALSRENTEATYRDVLARLPQGQKILERAYTAVEKVIKDVSDYVGEWLRYQALWDLQPDVLYERLGNNVSKWIQTLLEIRKSRATFDTQETRKEIFPVVVDYRKVQSKVSLKYDYWHREILQKFSCSVGQEMQTFYADISRWRSELEEQSVDSGSTSDAIQLITYVQQLKKKTKFCQEKTEQFRAAQRLLTQQRYQFPSSWLYSENIDGEWSALTDILERKDSAIQAQVANLQAKIKEEDEQVEKRTQDILNEWDKLKPVQGSQKPVEALATLNALETKLSKVKEDRENMVKAKGALEISEPIITNTHATRLDVAVEELTDLKGVWSALTPLYNSIEELKEKTWLSVQPRKLRQSLDELLAQLKQLPAKYRSYDSYEYMKRLMHNYSKMNMVVVELKSEALKERHWKHLMKELRVSWNLSDLTLGQIWDTDLLRYESAIKQVLLVAQGELALEEFLKQVREYWQSFEIDLVNYQSKTKLIRGWDDLFNKLKEHMNSLTAMKLSPYYKQFEEDSLAWEEKLNKISALFDVWIDVQRRWVYLEGLFSASADISTLLPVESSRFSSVSTEFLSLMKKVTASPRILDVVNMQGAQRVLERLADILTKIQKALGEYLERERSSFPRFYFVGDEDLLEIMGNSKDISRIQKHLKKMFAGITSIDVESENTVVTAINSREGERVELIRPVNLKENPRINDWLRMVEREMQHTLSYLLSQSLADFSKFDSAELEKYLNWMDQYPAQVVELTANIWWCMQIEKRLSEGKIVEEVQVTVDKILSMLADSVLCEQPPIRRKKIESLITEFVHKRDICRSLVANNVSHANSFHWLKCMRFYYDSRSTSPLSCCTVKMANAHFPYGFEYLGLQEKLVMTPLTDRCFLTMTQALNSRLGGSPFGPAGTGKTESVKALGHKLGRFVLVFNCDETFDFQAMGRILVGLCQVGAWGCFDEFNRLEERMLSAVSQQIQTIQEAVRAGGDMQVDLVGKTLSVNANMAIFITMNPGYSGRSNLPDNLKQLFRSLAMTQPDRQLIAQVMLFSQGFRSAERLANKIVPLFILCKEQLSDQYHYDFGLRALKYVLVSAGNIKREEIQRMIDNGESFGNPECDVSSNLSEQQILIQSVCETLVPKLISEDISLLFSLLSDVFPSIDYKPSPLTQLREEIAKVCDQLLLTQSSTAGELGSTWLEKVIQLNQIINLNHGLMLVGASGSGKTIAWKVLLKALERLEGVEGVAHVIDAKAMSKDALYGTLDPNTREWTDGLFTHIIRKIIDNVRGETSKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLAIPPNVRIIFEVSDLKYATLATVSRCGMVWFSDEVVTYDMLSDHFLRMMKHFRLDVEQPFDLMSLNTASVEGNNISPESERVLAIQQKCVQFLAHHMSADALVPATLNYAMSELDHIMEPTQQRLLSSFFSMMKYAVRQLIIYDNNHSDFPIADDQIEAYILRAMLVNMVWSFSGDGKWKSRQKLSDFVRQSCTLSLPPNASLPIIDYEASIMGEWVQWNSKVPQMEIETHRVAAADIVVPTVDTIRHEMLLNTWLSEHKPLVLCGPPGSGKTMTLLSALRSLQDMDVVNVNFSSSTTPELLMRTFDHYCEYRRTPNGVVLSPVQISRWLVIFCDEINLPAPDKYGTQRVISFLRQLVEMNGFYRASDHTWVSLDRIQFVGACNPPTDPGRHPLSLRFLRHVPVVYVDYPGSTSLIQIYGTFNRAMLRMAPAIRGLAEPLTSAMVDFYLQSQEHFTQDDQPHYIYSPRELTRWVRAISEAISPLDSVTAEALVRLWAHEALRLFQDRLVHAHEREWTDQLLNLTAEKFFSSACNLTHALERPLLLTKHYLPVSKEQLKEYVSARLKGFYEEELDVQLVLFDQMLDHVLRIDRIYRQPQGHLLLIGVSGSGKTTLSRFVAWINGLSVFQFVRQFSKFQLKVHSKYTAADFDEDMRSVLRRAGCRNEKMCFIMDESNMLDTGFLERLNTLLANGEVPGLFDGDEYTTLMSQIKEGAHRQGLMLDSPDELYKWFTAQVMRNLHIVFTMNPSGDGLRERASTSPALFNRCVLNWFGDWTDSALYQVGMELTNTLDMDKSDYQAPFAITAVCELVPSPMLYRHAVINSFVQVHNAVRKLNEVEAKRGRRVMAITPRHFLDFIKHYINVFHEKRRDLEDEKLHLNVGLNKIKETEEQVLELQKSLTLKSSELEAKKSAANAKLKEMLSDQQKAEKEKLASEQLQKELAQSLVEIGKKRTEVEKDLAQVEPAVEDAKQAVKSIRKAQLVEVRSMAAPPHLVKLTLESICLLLGENVGTDWKAIRGVMVKDDFMPRILGFDTDSITPETLKAMEKYIQNPDWDFDKVNRASSACGPMVKWMKAQLLYSDMLRRVEPLRNELKRLEDDAKIKTEKGEELKKTISQLEHSIAAYKEEYAQLIGQAETIKADLATVKEKVGRSTQLLKSLGSERDRWHGSCDGFSQQMDSLIGDTLLSAAFLAYSGYYDQHLRDMLFHRWISFVEQAQIKHRSDLARVEYLSSVDERLEWNKNGLPVDELCAENAIMLHRFNRYPLIIDPSGQAMKFLLKQFSGKNMTKTSFLDNSFRKNLESALRFGNALLVQDVESYDPILNPVLNREVKRTGGRTLITLGDQDIDLSPAFQIFLITRDASVEFPPDVCSRVTFVNFTITQSSLEMQCLNQVLRSERPDVDEKRNDLLKLQGEFAVRLRQLEKALLAALNESKGKILDDDSVISTLEKLKTEAAEVARKAAETNKVMTEVETVSQLYIRLAQACSLIYSMLQQLNEIHFLYQYSLDFLLEIFTAVLNTPHLSSITDYGQRLQIITSNLFQMVYRRVSQGMLHQDKILLALLLMRIVLKGNSKEPSYQLEVDISKMFLYIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULD2</accession>
    <name>A0A0N4ULD2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2517</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000065">
        <property type="protein sequence ID" value="VDN52544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULD2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULD2"/>
    <dbReference type="WBParaSite" id="DME_0000860201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000860201-mRNA-1"/>
        <property type="gene ID" value="DME_0000860201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000860201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="26008" checksum="5E69CB6982C32D28" modified="2015-12-09" version="1">MRYVHLLFFEAENERTRLQVQYEDICRCNHSPKCSVPIGYETFEGFHRENEFIVATWPKETEMLWQLIWEKNCQTIVVMGDENCFWTNLKVVGDLLITRDNDDLWIVSNKEDQLFVRTIVVSQCDFEFDTWAEIERLQQRRLQYHNGPLLILNYQNSSMAYILCLLTSIACQVESESCLDVLQFLSSYKEKLCGIWNSQVHHIPFYFFTHVTSIVMAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULZ3</accession>
    <name>A0A0N4ULZ3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10496</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001220">
        <property type="protein sequence ID" value="VDN60523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULZ3"/>
    <dbReference type="WBParaSite" id="DME_0000884001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000884001-mRNA-1"/>
        <property type="gene ID" value="DME_0000884001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="31"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000884001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44569" checksum="7FA6E61ECA8BCC82" modified="2015-12-09" version="1">MSIRTASIKDVHSYVGFANFPNQVFRRAVKNGFEFTLMVVGCSGLGKSTFLNSLFSAEIYDPKIPLTTPLSATTEITEKTVRMVENGVSLDLTLVDTPGFGDAIDNNKCWDPIINFIERKYFDYFSEETKIERSAYIPDKRVHLCLYFVAPTGHGLKPLDIEVMKKLHDRVNVVPIIGKADTMTTDELNRFKAQILKEIDNSNIKLYKFPEYDDEDERKQFGPLRDRYPFAVVGSNQMKEINGKRMRFREYPWGITEVENLKHNDFIAVRDMIIRTNLIDLIVVTKNVHYENFRFRQLSKGSKTDANDRDPFTQMEHERKVKEKELEEKKTSMENLDEREKENRKALQNRRLQLEQLMNDVVDLRKIGTLSRQESRSGTLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM03</accession>
    <name>A0A0N4UM03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2712</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000076">
        <property type="protein sequence ID" value="VDN52739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM03"/>
    <dbReference type="WBParaSite" id="DME_0000885201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000885201-mRNA-1"/>
        <property type="gene ID" value="DME_0000885201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000885201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16691" checksum="E278DD1BE2831C36" modified="2015-12-09" version="1">MYLVLNFICFICLLAGGPAYFSGAGWATFVTTVGLGVSLTLLCLYLFRIVDIVTRIPWIICEMIFCFAWTIFFFITASVLAVASVKYRTGAGYAAAAFFAFGAMCTYAFDCYLKFLAWKANEIATGGTPMTTTYSTGPSVQKKVVISEPYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMY1</accession>
    <name>A0A0N4UMY1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane and coiled-coil domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2973</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000093">
        <property type="protein sequence ID" value="VDN53000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMY1"/>
    <dbReference type="WBParaSite" id="DME_0000923601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000923601-mRNA-1"/>
        <property type="gene ID" value="DME_0000923601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF14">
        <property type="entry name" value="DEMENTIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000923601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46706" checksum="37CBCAD18365F1DC" modified="2015-12-09" version="1">KEYAERFDSSVRSSDGCTSNIDDSNVEEKIRIERKIDKIKEKLTRISLAREVASNMESGSENPQLIRVRQHFEKKNKKYAQEMDHLQKKLEQLQSRLNELELGIVVQPSPRAAVLNNIRRTAPLLREMTGSVISAPRGIAHIIKNTLGSADNISTNAKYSAAGHSIFYASSTENGERHNHCLLNDRSKSDGADFADISLRGNPDNFFDIQPGPVSISMNNDSSLTHSNANLSDLKEEINTLKLQNQFLVQQLEKIQRLEEILNDTIELHQAEMTALKADLNTIGTRMDYQYCDRFCSIEENIESTQNKMIRLESNLKEWSETSAQSAFSSILLTGANVLVEFLKLLLFIISVVLDFFKPFTGTRTRAGFVILIWMFFMISSQYINYFTLLDRVKKLFFALFTSRSGFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPH1</accession>
    <name>A0A0N4UPH1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10779</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001246">
        <property type="protein sequence ID" value="VDN60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPH1"/>
    <dbReference type="STRING" id="318479.A0A0N4UPH1"/>
    <dbReference type="WBParaSite" id="DME_0000985801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000985801-mRNA-1"/>
        <property type="gene ID" value="DME_0000985801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000985801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26490" checksum="752EAB8172D2C88E" modified="2015-12-09" version="1">MFNVLIECLRFAYIFLEIILKYATRPFLLFKDFYEERRKLSLRIPNHIAVLYTEQSAICMEMLSDLILHCVSVGIKKISIYDPWSFVASNKDLLARKATVKVSKVNPKLVSFIHFVTKMDILQSDVSGLAVILLGKDSGRETLVSVCRKMCVIHNPSAITVGKIGKAFADENVFEPDYLLRIGSVKSMAGFPSWALRLTEIISIKRLKGRMTQDYFLALLNDYSNRDIRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPK6</accession>
    <name>A0A0N4UPK6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10801</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001249">
        <property type="protein sequence ID" value="VDN60828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPK6"/>
    <dbReference type="WBParaSite" id="DME_0000989801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000989801-mRNA-1"/>
        <property type="gene ID" value="DME_0000989801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873802at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000989801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="54033" checksum="E8DFEC55F0E3D6CF" modified="2015-12-09" version="1">MVGLYQYNSYSEKKKEEEENYAQMADNEKGILNLITDSKEAVIILGMHNRDWKTIVEAIERILCQLETVRENPEHSTIEILIESKLPGWILDKVYQQKDDEKSSLKHQRAFCDNRPQQFKQLDICPYQKGKSKSDHEAAIINTISEKEREVLLLCKEIIVFNTENSECYEEVLFDIGKKLSFVSRELVNRLELEEILYINIYTTRENSTIEIKIFSISNQIGTPRFAEVDISKKFEKQDNKNPVDVALRGLSPIDFRNFNSSWYGPSWTWKPEYLTSLRERTQKEISSPKREEFISPRVILNKPKTLRGIWKLSRIKEHQGKDGKLWASTIELSNGKKIEIQESIVMRIRASERRMSEVEHINVINSRLAINDGYITTDSAISLEIRKILHKHKEINGIILKQIAPGKHNSRLASKMISDNGNPFNTITIGKGVASVTWYAIGRLGNTRLTTSLMQKSKQQEDCPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPQ8</accession>
    <name>A0A0N4UPQ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3507</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000142">
        <property type="protein sequence ID" value="VDN53534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPQ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UPQ8"/>
    <dbReference type="WBParaSite" id="DME_0000995601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995601-mRNA-1"/>
        <property type="gene ID" value="DME_0000995601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF69">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23351" checksum="DBD4405F9DD5DA36" modified="2016-06-08" version="2">DLFKRHPLNCRWSLWYLKGDRNKDWEDCLKKVATIDTVEDFWALYNATQSASGLNWNSDYYLFKEGIKPMWEDENNVKGGRWLVVVDRQRRAELLDQYWLELLMAMVGEQFEEHGEFICGAVVNVRSKGDKVSLWTRDSMQDEVNLRIGLILKSKLNIPDTQIMRYEVHKDSSVRTGSMVKPRITLPLNGKFDILNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQH0</accession>
    <name>A0A0N4UQH0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-alpha-acetyltransferase 20</fullName>
            <ecNumber evidence="5">2.3.1.254</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionine N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyltransferase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">N-terminal acetyltransferase B complex catalytic subunit NAA20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-terminal acetyltransferase B complex catalytic subunit NAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NatB catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS3755</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50484"/>
            <dbReference type="Rhea" id="RHEA-COMP:12694"/>
            <dbReference type="Rhea" id="RHEA-COMP:12695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133356"/>
            <dbReference type="ChEBI" id="CHEBI:133358"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50480"/>
            <dbReference type="Rhea" id="RHEA-COMP:12692"/>
            <dbReference type="Rhea" id="RHEA-COMP:12693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133045"/>
            <dbReference type="ChEBI" id="CHEBI:133063"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50492"/>
            <dbReference type="Rhea" id="RHEA-COMP:12698"/>
            <dbReference type="Rhea" id="RHEA-COMP:12699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133361"/>
            <dbReference type="ChEBI" id="CHEBI:133362"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50488"/>
            <dbReference type="Rhea" id="RHEA-COMP:12696"/>
            <dbReference type="Rhea" id="RHEA-COMP:12697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133359"/>
            <dbReference type="ChEBI" id="CHEBI:133360"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.254" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000180">
        <property type="protein sequence ID" value="VDN53782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQH0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQH0"/>
    <dbReference type="WBParaSite" id="DME_0001025701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001025701-mRNA-1"/>
        <property type="gene ID" value="DME_0001025701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN53782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0001025701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19953" checksum="EECC38E5C4AF763D" modified="2015-12-09" version="1">MTTIRPFNVFDLFRFNNVLYGFSFYLQYLINHSEYFQVFEHPNGEIMGYVMGKAEGEKENWHSHVTAVSVAPAYRRLHLAARMMKSLEEISEMRRCYFVDLFVRVSNNVAINMYKSLGYIVYRRIIDYYSGKFEEDAYDMRKALSRDHQKKSVVPIKLPVSCNEIDLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQQ8</accession>
    <name>A0A0N4UQQ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10890</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001266">
        <property type="protein sequence ID" value="VDN60917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQQ8"/>
    <dbReference type="WBParaSite" id="DME_0001036101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001036101-mRNA-1"/>
        <property type="gene ID" value="DME_0001036101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF0">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039256" evidence="2">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001036101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26368" checksum="EF19D3D0511BF7D6" modified="2015-12-09" version="1">MLLNFCFFVFLIHGVKSGDKEIENCNREVGGRQRPTVDPSRCAHIDSPACIAIFPYDAGDIAATITSHFNPNENYKIPEKCTNADLKDFAEKNCPSHCAFCCKAKQFNCANDPFAGDHCDAFTLEMCRNAALNTIALMRCPMRCGLCDRPGAGGICPNTFDDAVCTALVAVICLDEKAKNSCQKTCGLRTCLENQNATAAQSNCRDDDQQCSENRKYCTIEPYATVMRGKCRLTCGHCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQU0</accession>
    <name>A0A0N4UQU0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001267">
        <property type="protein sequence ID" value="VDN60922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQU0"/>
    <dbReference type="WBParaSite" id="DME_0001039601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001039601-mRNA-1"/>
        <property type="gene ID" value="DME_0001039601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039590" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001039601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12155" checksum="32272A7CE27118FC" modified="2015-12-09" version="1">MLFLLIALIFVRKGESGEGVQLNKCLAPGGVARPLPPPSACKDKDPVICSAIFSPRVPDIPLNAVATNPFRVNPNCQNVTVMANAEALCPSSCAVCCLTPEFNCQNYTMYPNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQV8</accession>
    <name>A0A0N4UQV8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10901</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001269">
        <property type="protein sequence ID" value="VDN60928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQV8"/>
    <dbReference type="STRING" id="318479.A0A0N4UQV8"/>
    <dbReference type="WBParaSite" id="DME_0001041601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001041601-mRNA-1"/>
        <property type="gene ID" value="DME_0001041601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852176at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="86"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001041601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19589" checksum="767B464C4A5868CF" modified="2015-12-09" version="1">MRQHNTTFLPDVVFFLQCLLNEQVPASDMQMLYWSNELARSAQRHANRCDFSRGNLSKWMDNLNYHHSADKNLLPGTTWEMAENDVNPLRGAIKKAYTAKPYDEFCPGCQCKVRTRQKFTTGRLTWILAIIGCLFFIPLAVVPFVVRPCKDVLYFCPNCNALFSVRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URF0</accession>
    <name>A0A0N4URF0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4050</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000261">
        <property type="protein sequence ID" value="VDN54077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URF0"/>
    <dbReference type="WBParaSite" id="DME_0001062901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062901-mRNA-1"/>
        <property type="gene ID" value="DME_0001062901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804200at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720775" evidence="1">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13622" checksum="B575CFEEB7A90CEB" modified="2015-12-09" version="1">MLTAIPLFFLLPLAFADNVDIEECVKLVGNDHKKRPTVDSCPEDPVCSTIFVFNPPADIANNLNMQIFKNLTKIFCTAGNATSSSTCTDLHPQCQANARYCNIGDYAVVMRRVCRLTCHHCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URJ7</accession>
    <name>A0A0N4URJ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">POU-specific domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4096</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000287">
        <property type="protein sequence ID" value="VDN54123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URJ7"/>
    <dbReference type="STRING" id="318479.A0A0N4URJ7"/>
    <dbReference type="WBParaSite" id="DME_0001067901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001067901-mRNA-1"/>
        <property type="gene ID" value="DME_0001067901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF137">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific" evidence="5">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001067901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22020" checksum="997340492A2551E7" modified="2015-12-09" version="1">MDHTSCTAIRQAISEITLEERIELKELEIFAKEFKRKRKNFGLSQSNIGVDLGCRFGIDFSQSTISRFETLSLSFNNMAKLKPLLKKWLAYAEDAVANGAKIRTLLEAARNQSQNRFPSKVFEMSNSGTTEAAGMRESGRLLKKRRKRTILDVWQKVPLALYFKLNPRPDHYRIARLAEILELNRDVSLSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URP2</accession>
    <name>A0A0N4URP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4131</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000318">
        <property type="protein sequence ID" value="VDN54158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URP2"/>
    <dbReference type="STRING" id="318479.A0A0N4URP2"/>
    <dbReference type="WBParaSite" id="DME_0001072401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001072401-mRNA-1"/>
        <property type="gene ID" value="DME_0001072401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001072401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16284" checksum="2966EA1C634F97EB" modified="2015-12-09" version="1">MALTCPGSKITEEMRSYVLKEHNKLRSQLANGEAEASNGLMPRSSNMHELEWDCGLEERAQQWAEYCDFEHSTQEFRNYSGENLYARWGYEEPKLDKKQFEDAIEGWWWEEIKDMPAHSTMDGTPGSVLHFTQVTFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URR4</accession>
    <name>A0A0N4URR4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4149</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000331">
        <property type="protein sequence ID" value="VDN54176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URR4"/>
    <dbReference type="WBParaSite" id="DME_0001074601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001074601-mRNA-1"/>
        <property type="gene ID" value="DME_0001074601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230045" evidence="2">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001074601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17793" checksum="DD44782277FA2F59" modified="2015-12-09" version="1">MLRLLVLATLYILVDGAAVDLNVCFMLVPTAQNPVKRPTVSVENCQDRDPAACFEIFKPDDNAALGQVLADNRMPNMGYKVRDTCQQDAYKMLARQMCPQTCATCCLTKEYNCENATTLSPPAATCRDERLNCAAIKAAHSCGGVFRTTMMQQCARTCGYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US91</accession>
    <name>A0A0N4US91_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4314</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000703">
        <property type="protein sequence ID" value="VDN54341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US91"/>
    <dbReference type="WBParaSite" id="DME_0001092301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001092301-mRNA-1"/>
        <property type="gene ID" value="DME_0001092301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001092301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24258" checksum="3E951A60152DD163" modified="2015-12-09" version="1">MEDYGTYYDNYENYKMDERPTVQYTVCKFWPSGFMFKKLYKKGKQCEAGWPCCRPNSICNKDGLCETEKGLNEIEFHVDKRKCDKGKFPCKKSALDAMNKFRIQLAAGNISAKNGNFPMGKEIYKLRWNCTLQALAQQVATECEYTLPRMDPSDIGEVYLRWNCTLQALAQQVATQCEYTLPRMDPSDIGEVYLVLNNSSSKSEQNFQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q309</accession>
    <name>A0A158Q309_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5768</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q309"/>
    <dbReference type="STRING" id="318479.A0A158Q309"/>
    <dbReference type="WBParaSite" id="DME_0000140801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140801-mRNA-1"/>
        <property type="gene ID" value="DME_0000140801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250687" description="hydroxyacylglutathione hydrolase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="41"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29079" checksum="8A9B95A53B7523EB" modified="2016-06-08" version="1">MIYSKYFLLPTFLMVLGVKFSEIFSSVRNMMRIVVLPALSDNYMYLLIDNTTKQAAIVDPVDVTKITKAVESEGVKLCSALVTHHHYDHAGGTRELFDTYKGQISIYGFDERINKLTNKVADGDKLTVGNLKIECIHTPCHTSGHICYYTVDDNNQKAVFTGDTLFIGGCGRFFEGTAQQMYDALCVKLAKLPDETEVYCGHEYTTSNLLFARSVEKNNKKIEEKLKWSKMKDNSKEFTVPSTIGDEKIFNPFMRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3V8</accession>
    <name>A0A158Q3V8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dna replication factor/protein phosphatase inhibitor set/spr-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7446</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3V8"/>
    <dbReference type="STRING" id="318479.A0A158Q3V8"/>
    <dbReference type="WBParaSite" id="DME_0000328701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000328701-mRNA-1"/>
        <property type="gene ID" value="DME_0000328701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000002">
        <property type="entry name" value="Testis-specific Y-encoded-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000328701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28822" checksum="8D27892831BE665F" modified="2016-06-08" version="1">MSEPAAKRAKLDYENATQKILEQIDQVQGEIDSLNEKASEEILKVEQKYNSLRKPFFDKRNELVKKIPNFWVTTIVNHPNISVLVDEEEEECLHYLLRVEVEEFDDIKSGYRIKFVFEENPFFENDIIVKEFFLGNAEPTSTTTEIRWKSGNNIINKVELNQGDSPGPRSFFIWLTENQDASNDEIAELIKDDLWPNPLQYYLIPDLEAGPEEGDDDDDDDDELVGSDNDENVEDLEEADEVGEDHEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q413</accession>
    <name>A0A158Q413_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="10">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7745</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q413"/>
    <dbReference type="STRING" id="318479.A0A158Q413"/>
    <dbReference type="WBParaSite" id="DME_0000374001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000374001-mRNA-1"/>
        <property type="gene ID" value="DME_0000374001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF28">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE SEK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="14">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="532"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000374001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="840" mass="96360" checksum="D1CEEB68B32AEB7E" modified="2016-06-08" version="1">YESVSGERIQIDIGSYQKDKSDNNSANSTKSFKSRLTFYPFAYALHNSELCDHCWRCTGCSCGMFCDEKCQSLGWKDHRIECRALKKSCGIPDIETRLLGRIIIRYEAIKLGKDKKDQNFYVDRTSQRSIMEICAHTDQMRKDYTAMKKFNRIFNKVIDFYGARNIPDEDEVFELHCRNFINRHAISDEAFLREIGKGLYLDLCAYNHSCRPNSIYTCKGFVATLRSLDLSTNLLDRSSTFYTYIDLLNTTQERRRLLKDTWYFNCECSRCTDENEGLLSSMLCPNCEKPKPLQIFGKVPYKDQITLIITCPECHEQVPREKIIEAVETMRFINGIIENNEIEQIASNQRLSFLTELRNRSGKVLPNINIYYCKIIQFMIPLVNPSNYKLLLELHLDSEACIRFCYPANHPTLALHLRNIAIFYLRNGSPHRAKHYFECAREILHFTLDVNHSMSIANQVLLNEAIESSLQGILQSRNCNIGDTKVCDVQLVPEGTKDIENISNLSFIRMFISDKLSFPDESREFGFGFEDLTDIGPIGEGAYGHVNKMRHNGTGRLMAVKKVRIISGKCDDGETNRSLQRLRLEIDAINRASDCPQIVRFYGLTFHEGDCLVCMELMDISLEKLYHTVHNLFGVFDERILGHVAVSVLKALNHLKNEIQIIHRDVKPSNILLDLKGAIKLCDFGISGYLVNSVAQTREAGCRPYMAPERLLTSAAYDIRSDVWSLGITLEEVALGRFPYPRFNENELFVQLEQVVYGDAPIMGPSDTYSIMTVKFINSCLIKETDLRPNYKKLMDTEFFKFYDNLEGTSVYVASYVQTALTQLQLNVDSLSDCFADHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q458</accession>
    <name>A0A158Q458_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS438</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q458"/>
    <dbReference type="STRING" id="318479.A0A158Q458"/>
    <dbReference type="WBParaSite" id="DME_0000407401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000407401-mRNA-1"/>
        <property type="gene ID" value="DME_0000407401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="13"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000407401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53756" checksum="4662EEBE92CF2AAB" modified="2016-06-08" version="1">MKSVHLHINRFHILIFVLWQLALAFVAQEVFPTFFNYYPQRLSDYKRTMNFSKKICKDDGQEQCELLSDCKNITVLKTPFYGIVEHFHLYCGDDAYSATLVATWQFLGVFCGTVIYGHVGDLLGRKPTTIIGLLIGLISGIISGFATSWKWFAVFRFVAGTSMACIVVVFSTYVMELILPEQRVFLRSFFNWGYARAILTLICFLLPRWQYTSIANACLVLPVILAIFFVPESPKWYAAKANPSLSFHPHIYTMRDLFSNKNTAFHTIPLCAIWFFGGVCTFGIDLNSKNLGGEFFLNQFIMSFSIAIIKAGIFFVDTYVPKFGRRLLFQIPQSVMLICFATISLIMIINDSLQCETSLINWTIIILNFIGISFVEVTWDALYICVAEYFPTEIRAIGTSTCSMMARVGTLLAPQIVYMASFYKPALYIAVVIVGGSSLLLSVIYLPETKGVELSSVNYLELEQSKKRSNATASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5M7</accession>
    <name>A0A158Q5M7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1975</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5M7"/>
    <dbReference type="STRING" id="318479.A0A158Q5M7"/>
    <dbReference type="WBParaSite" id="DME_0000777801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000777801-mRNA-1"/>
        <property type="gene ID" value="DME_0000777801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000777801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25291" checksum="4C413516825F467B" modified="2016-06-08" version="1">MKNVYIFIFTNLFEISLIILTDKIQKEKAKRKTFRCGQCGRTYETFYNYKEHLAKHDGKLFECLICKKQLSGQSALSRHSKIHDKPHECVICSNRFSSTYDLDCHFSYYHSTFKRFKCEYCDRVLYNYSGKLRHERLCVRKKIGIEQKSSINDPEKFQLKSQKIEQLPNESKTNLPQSLKQREVTEGGRIKFHIMDILSDIPHFDAKNQKATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5U2</accession>
    <name>A0A158Q5U2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2323</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5U2"/>
    <dbReference type="STRING" id="318479.A0A158Q5U2"/>
    <dbReference type="WBParaSite" id="DME_0000829301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000829301-mRNA-1"/>
        <property type="gene ID" value="DME_0000829301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000829301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36224" checksum="2E416EE302B80288" modified="2016-06-08" version="1">MIKYHSYEWKKKNQRRFWCWNYAYDLSPLLGLSWLVTLKDFFGIKPISLDDDPIKVLFKAWLLRKKSHYDEAVEELHKALGLAEEKKQSIPITRIYDELANTYYEMGNLKDAETLFRVLLKRLVELHGKHQKDPEFIAASLKLSDIYAQKNEIDKAETGYQFCTSTQNKIVEEHVRNYSSSGEIETDFRNNVEQHGTVYTDPLSLFGMCLEQYAHFLVKYRDESRLKEAENFMDEAVRLSHHIFGPASFHTVNMLNNFGAVLINKNRFELARKFLEIGIDRILYINECSSLVPGYFCNYAEALFHCGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5U5</accession>
    <name>A0A158Q5U5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10345</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5U5"/>
    <dbReference type="STRING" id="318479.A0A158Q5U5"/>
    <dbReference type="WBParaSite" id="DME_0000832801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000832801-mRNA-1"/>
        <property type="gene ID" value="DME_0000832801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000832801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="854" mass="95761" checksum="3ED9EBF9FBA52B57" modified="2016-06-08" version="1">MSLITCLHAERNIAELIKLASLDQQLSNRVRHPALRKSTAINDEILDEENSDPDQGTWDSNNIAAISSLMRRAQSNLPTATIHCTKSEPLTSEDIGIIPAIRSIIGTHAHSVPPTRTSRLLDIAAMGSVRSCDIPFPEDAGSVSFFDSHASNRHQQIGADSSIGSSSTIRDTGTTLPLNSVLVPPKSVIQDDIRMKLGRFELVKKKGRSEVWNLFGQVLDTKTGARLPYVACYACKVLYTDTGGGTGNMTRHRCPMGTSYKDNSACLSMDGSSADISQQQSSFDATNSVNGQMSPDTASFYQRESPVPSQPHNTLIGQSSFDQSFSFSENDRRAFSHAAVRCCAMDLLSPNVFQGEGIRSLIETTLAIGRRYRSSERQLVSTLIPDTLTLQQMIDTGTNLALNEVKTEITNQLQGAGISFSIEQISGLNELIVISANYISADWKLTRRIIRLLFINLLPAIEKIILGYATGISRLFVVSAEELPFTEAYQTAPCICSKLNEIIKCILEEVFDSDQNVLEAISICRDIAESLEKMGMERWLNGVDEKIGGSFDYLFYVYNLLKNVQRCVHDSALSQCPQDLISLIERADWHFINDLKRFLEPFHVMASIFSANSVCNFHMVLPEWFALIHEFSSDGEIVTNDETSKWFSKMRNIAEKRLCSETDNIIRTEHRIATVLNPRLKHLPIICTDLQRFFIFFFVFYIDSWLETYAKIRSLIGLSDSKNSKKCDDYFSSESVDIEPQRKRICFLSSLEDRAMIDDELECYLRSQFPAVQTKNVLQFWSTVGVSQFPNLSQLARYLFSIPAACCKHKNQILPGFISDSLSNLLILRSFYDSSSQDSLASQPTNRQKWKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5X6</accession>
    <name>A0A158Q5X6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15 16">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 15 16">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS10398</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 16">Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15 16">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 15 16"/>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5X6"/>
    <dbReference type="STRING" id="318479.A0A158Q5X6"/>
    <dbReference type="WBParaSite" id="DME_0000853101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000853101-mRNA-1"/>
        <property type="gene ID" value="DME_0000853101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="18">
        <location>
            <begin position="12"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="17">
        <location>
            <begin position="210"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN60425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000853101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45669" checksum="2B4D153168EE0358" modified="2016-06-08" version="1">MRDCNEIRVVVPINIALIKYWGKRDEVSHKFLRLKIMLTYENMLPLNDSVSLNIDEMYAETLVRVNSLINDDSVSVNGISIDLTENLRYKRCFSVSCKMLEVRRLLHEKTISTSCDIIALKFEIISVTNFPVGAGLASSAAGFAAIAYAFGKLFNFSDKEIAYIARIGSGSACRSIFSGFVHWKAGNLNDGSDCLCEAIASKEHWLSIRALILITSHEEKTVSSSEGMRRSTLCSDLLRFRAEHIVPERVERLKEAILARNFEAFAHIIMKDSNQLHAVCMDTYPPIKYLNESSWNLINLVDCLNNYFKQSRVAYSFDAGPNCCLFMESNFVPIILVVLKKFCNLSDDIIERITRSGVIDCDNLKEQIKNMEKYLDLNEIKPVSVVVKDAYLSCVGTGPHVIAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6A5</accession>
    <name>A0A158Q6A5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3234</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01000115">
        <property type="protein sequence ID" value="VDN53261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6A5"/>
    <dbReference type="STRING" id="318479.A0A158Q6A5"/>
    <dbReference type="WBParaSite" id="DME_0000956701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000956701-mRNA-1"/>
        <property type="gene ID" value="DME_0000956701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="10">
        <location>
            <begin position="324"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000956701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="57409" checksum="8889AC4340FC36E3" modified="2016-06-08" version="1">MLCRRCRGAVVKKHCTNVQLSSALSFFKPSCMSVVGRSLQYSHENMRVKRLLLGSIRKRPQNDGFIDRFSKNSLEELFKTMGKEQFREADLSRKVESIQFTAGSADMVKQAAHIPIINSKFYDGVPGKFTPMPYGPLDTRLGTCQKNIDCATCKSNLVDCVGHFGYMDLALPVFHVGFFNSVMHVLQCICKSCSGLLVSDEIREKFLNELRKTSLDYLKRKALHKRIVASCKKNTTCPHCGSKNGVVKKATGAVLKIAHSDTITENRLPEFFAAVEENKELHSLLPRIKFDVLDPVHVQDIFSKIRMEDIPLLMARDSEMKHPLNLLLTRLPVPPSCIRPSVISEIKSGSTEDDITVKLSEIMLVNEILRKYVEDGVQVALYMNSEISGLPVEMQPKKNTRGFAQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLHIDQVGIPIFIAKTLTFPEIVNEANIELMRKLIINGDDIHPGANHVVDRITGNKRFLRYLFSIYRNIIFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6D1</accession>
    <name>A0A158Q6D1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3401</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000130">
        <property type="protein sequence ID" value="VDN53428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6D1"/>
    <dbReference type="STRING" id="318479.A0A158Q6D1"/>
    <dbReference type="WBParaSite" id="DME_0000978701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000978701-mRNA-1"/>
        <property type="gene ID" value="DME_0000978701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5784299at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF116">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="104"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000978701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="32249" checksum="350AA3EC30E79ADC" modified="2016-06-08" version="1">MRRIKILERISTRGNLSYNVSRIDGMLEYDRVARFDRALWKYSWVVFNSFTNGQWGEEERKKNSLNRHQMIDVRIRTLRDHFEISCNRKEFKTFRYRLPLSLISRVLINGGFYPRHMIDFKGKIYPVPYERKLLDRWEELIILGRPNREAYRFAINLLNEEDDIMLHFNARFDENCVVHNWFVDYKWGHEDRIEPVPFEPYTDFDLKIIRAKQEFVIFVNDQPLRTFPYRWDIGELIKMQVMGDVELNIIGHRPFAKDNTALYNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNQ2</accession>
    <name>A0A3P7PNQ2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNQ2"/>
    <dbReference type="STRING" id="318479.A0A3P7PNQ2"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="223" mass="25252" checksum="A2D750938A7C28B9" modified="2019-02-13" version="1">MALFPFEMMPVFEHFFHISRIPSIYFTKELLNKSKSNKIPLHVDGKNTYYLVDPGGDLHDTRTLFSKLLKKYDCWKGCVGEAPQSKDLLQYMGHGSGIRYFGTDDLRKCCCRAVSVLMGCSRILHEGRGFDGRGHVYDYHIAKCPCLIGCLWTVSDGEIDRFISCFLEYSFFSSNYRFLLDGIGIARYACKLRYLTGASVVSYGLPITVDITGIRASNGEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPP3</accession>
    <name>A0A3P7PPP3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPP3"/>
    <dbReference type="STRING" id="318479.A0A3P7PPP3"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="221" mass="25303" checksum="DDC06846AA1976E4" modified="2019-02-13" version="1">MAAKEGRMLTIAPDEVCGINPCNKNCSTEYEPICSSNFITYPNRCVFEKAQCKQKNLELLYNAFISILGECRDCFSNSCPEPSENEPDLNFVCDQAGENKTKCEFEMLRCIYEKKFGYNITIAYVSTIFLEGRCCPAEEDCPTDFQPVCDSNGITHKNRCKFNVYQCRAKKILKMAVEFVKNWACDDKRPSIAKALIGILRSLYTLYFIYATKIFIFRNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPV0</accession>
    <name>A0A3P7PPV0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPV0"/>
    <dbReference type="OrthoDB" id="5816548at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="103" mass="12310" checksum="CD4481DEE74C5D0A" modified="2019-02-13" version="1">MDFYFYYLDRCPENYEGDHCQWPICGIHGRVNVITRTCECYSNFAPPFCQDCLPRFWGEKCSHSLLLSTDARDLDFFPFCRIIFVSFSLFLIYISKKPFLYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PR13</accession>
    <name>A0A3P7PR13_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS2876</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PR13"/>
    <dbReference type="STRING" id="318479.A0A3P7PR13"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000076">
        <property type="entry name" value="Glutamate-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000074">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="41"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="52148" checksum="3E290A9A37D2B46A" modified="2019-02-13" version="1">MKKHRKPLKFSKNYASTSTIYKYHWHFRETRDFLQFLRRINYDHRQLPENPDNAVEIHVSIVVSTIRAVSEVTMDYSLELFYRESWTDNRLSYDKRKFQNKSEIALHESYTNFLWHPDTFMPNAIASKNPQKQSISHRSLLRLQENGNVLYSRRLSVIAECPMDLTLFPFDSQICKLGIESYGYTADQVRYKWSKGIKQALKLHKIRLPDFQVKEAYVTSQLESYATGNYSRLYVCFIFSRAAGFCFLQLIIPSTAVVITSWVSLWMENETSFQDMISIILTITFLLFSYNEVMPRVSYIKAMDVYLGVCFCIVFFSLIKLALVKYMRQRLRMTRSFSIRILIILINENLAKNSKYYSFIVQQFYQIWKFFLEKGGCLTDIIFTPTFMHRFHWITQMTFFFGFIAFCLFYFLIYPNIHHDIADPACDREFAEWFAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PTB3</accession>
    <name>A0A3P7PTB3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000220">
        <property type="protein sequence ID" value="VDN53953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PTB3"/>
    <dbReference type="OrthoDB" id="5868576at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="161" mass="18824" checksum="021F0A9A82446158" modified="2019-02-13" version="1">MAYIESKIKKKDELAKLPQKNQTLGNDNICQSKCKEKFRTGFDMIKVHLAFGTIGVPSVIDEIDLMLFCRLDMQHDNCLKDCGFSIKFNIRDFICYAHRCRLLLCDLQCTKSAIFQANDAQSSRRAMEFLISYSRKQVEIIFFRKTKESCRENLDLYLQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PX41</accession>
    <name>A0A3P7PX41_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01000425">
        <property type="protein sequence ID" value="VDN54248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PX41"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="348" mass="40337" checksum="357CC0FDC2E58F7C" modified="2019-02-13" version="1">MQIEFRNPAAGALNIVACFSPLFLSDNWQLLLISLELHKFYGASLQVHYIQSILSETMAILKIYEAQKVVSIEPWSKINFDKLNIAYDPNLELNWRNQESAMCDCLLKYKESASFIIFGDIDDVLIPRMSNSFFAEFTYFHSLFPKAAAFLYDRHQVSIKAERNPLNFSLARTISRTKITNDLDDPKSIAIPSRIHSTFIHWPGIVLPGYNIQRIKNTTNFMLHLRHWQSEVIAKNISELKISKNVTREIDRTFHNFVEKYAIKEFMDLPSRNFYFPLIEQCYNAIFYSKAKQPDFCPTPMRCNVTPVIGVRCTLGKNIYKSNKLGGITVHTVQWTGYEEFDDGCRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q263</accession>
    <name>A0A3P7Q263_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptidyl-prolyl cis-trans isomerase E</fullName>
            <shortName evidence="9">PPIase E</shortName>
            <ecNumber evidence="4 9">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 9"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q263"/>
    <dbReference type="STRING" id="318479.A0A3P7Q263"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016304">
        <property type="entry name" value="PPIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF575">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001475">
        <property type="entry name" value="PPI_cyclophilin_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="309" mass="34088" checksum="4CB613987B6A537B" modified="2019-02-13" version="1">MALSTNFPHNKKRTLYVGGFGDEVNEKVLEAVFLPFGDIVGISVPMDYETGKHRGFGFIEFELAEDAAAAMDNMNDSELYGRTIKCNFARPPKPNEKSHRPIWADDEWLKMYGTGEGISKEAKEINDSDADTSVAVNVKKSPLPRVYLGIKIGIRYVGRITIELRTDVVPKTAENFRQLCTGEKGFGYEGSKFHRIIPQFMIQGGDFTKGDGTGGKSIYGTKFADENFELKHTMAGTVSMANCGPDTNGSQFFICTAKTDWLDGKHVVFGYVVEGMTVVKQVEQQGSKSGKPMMQVTIVECGEVKDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QPP6</accession>
    <name>A0A3P7QPP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QPP6"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="185" mass="20904" checksum="0A1211E505101372" modified="2019-02-13" version="1">MEFLLSIPFFKWVRFVKFGNAPAREMAEKNLDKRWLKDGGVIDAKNQNNDWSCVTKFRKNDRTIEFVLIISITKKKANFSETQQVLVAVAEDRARSSKKDPQDELDGIIEKLAKLEAPSIKGASKASADGVYSRLTDHTKYTGAHKERFDAEGKGKGKAGREDIKDDSGYVAAYKNKDTYHKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SWJ7</accession>
    <name>A0A3P7SWJ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS4842</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:34936"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Gly) + glycine + ATP = glycyl-tRNA(Gly) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16014"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SWJ7"/>
    <dbReference type="STRING" id="318479.A0A3P7SWJ7"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00935">
        <property type="entry name" value="GlyRS_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000022">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00762">
        <property type="entry name" value="WHEP_TRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="17">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="57"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN54869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="636" mass="72358" checksum="78D821796ECD476A" modified="2019-02-13" version="1">MAPLRSAVKEYGDLIRELKEKGAPKVDIDRAVIELKARKKRLEDREFELAPKEASFDRIKLEDLLKRRFFYDQSFSIYGGVNGLYDYGPMGCAMKANMIALWRKHFILEEGMLEVDCSVLTPEPVLKASGHVDRFADWMVKDVKTGECFRADHLIKNHAEKILQDPKTDISTKNALTDVLAKLEGFDNNDMQEVISKFNFKSPVTGNDLTEPIAFNLMFPTLIGPTGDFKAYLRPETAQGIFVNFKRLLEFNQGKLPFAAAQIGSGFRNEISPRQGLIRVREFTMCEIEHFVDPNDKKHSKFSKVSDHKLNLLSACNQLAGKSAETVSIGKAVKEGIVANETLGYYMARVHMFLVKVGIDPRRMRFRQHLSNEMAHYACDCWDAEILTSYGWIECVGNADRACYDLQQHFRATNVKLTAEKRLDEPKTINVTEIVPNKSAIGSKYKSDSKKGGEIDLTKELFSVKRYEKKIHVEEITPSVIEPSFGIGRIFYSVLEHSFRQREGDEQRRFLALPPMIAPIKCSLLPISSNSELDPILEAVRDQLVEYEISFKLDDSAGSIGRRYARTDEIGIPFGITVDFKSQEQPWTVTLRYALTMEQVRLKVSEVGSVVSNLASERINWQNILETFPKFEQNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SYU2</accession>
    <name>A0A3P7SYU2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SYU2"/>
    <dbReference type="STRING" id="318479.A0A3P7SYU2"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000326">
        <property type="entry name" value="ER membrane protein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="276" mass="32311" checksum="B8CA7162A59EB5B7" modified="2019-02-13" version="1">MKQWREEHVRRSEEVVEIWEFVLSRYPRSLGDELWLIYEQVCIAAYDCARIDVAVECIRALQEKFPRSNRVLKLQAMRFEAIQRYDDAFHIYEQLIESDPTNMSCRKRKIAILKAKGEKQEAIRELNEYLKVFLNDSEAWLELSNLYLQEQEYSRAAHCLEELILMSPHNSLYLRRLGEIRYSQGGQENMEMAKTYFEHAIRTNPGCLRSLYGLLLCCNWLSQKATGSKKKDLIQSGVGVIDKILSCYDNASENVNSYISKEMQTVETLLNHLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T1I1</accession>
    <name>A0A3P7T1I1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T1I1"/>
    <dbReference type="STRING" id="318479.A0A3P7T1I1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="212" mass="24204" checksum="B7B7C893DE6956F9" modified="2019-02-13" version="1">MVVANGIAAALKQIPRWMKFNSCHTYFCAKAGNNIYVEYRVEEICTNDEFCTYEVQAFQNGKIILKSQLSFQKVGAILESIAHQCHMPVTPVPDFCSTVSEAIDQLLEERNEESASISDEMKEFAEHIRQHPINDIFDIRLVDADSFTSAVMKGFFTKLWAKSKFEISELIGRGFSPSKLVPIDYCLWIHSDDIKMTDWLMCENHFSIASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0K4</accession>
    <name>A0A0N4U0K4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rep_fac-A_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4448</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0K4"/>
    <dbReference type="WBParaSite" id="DME_0000008801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000008801-mRNA-1"/>
        <property type="gene ID" value="DME_0000008801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799079at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000008801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23179" checksum="AA51F130D7D46D67" modified="2015-12-09" version="1">MDKETNLPSLTLYRKYQRKTCNLCLHELLLYTNKGRSHYTSSLCRKFNANELRQMLDNAGAADNRAYTAVTLEEAKDDRNGTVLQEPGYQMAHFKFLESELTKNIHMRSAKLYQLPFFPSYIDEKFNKICELNQINSGTSEQLEPCNQHGDNDSCISCKEIYMLEANCFPRFISSTRCLKEHMSCNSGEIKYGDDIFIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N7</accession>
    <name>A0A0N4U0N7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4483</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N7"/>
    <dbReference type="STRING" id="318479.A0A0N4U0N7"/>
    <dbReference type="WBParaSite" id="DME_0000012301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000012301-mRNA-1"/>
        <property type="gene ID" value="DME_0000012301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000012301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25283" checksum="7AD6654CAD6558C1" modified="2015-12-09" version="1">MRIGHPRPPSPFDLFIRSRVGVVRSDKQVLSTKDDSMNNKIGQISSKKIDRNEKEHLEQRKVSLLEQIVRSHPIWYLPYIGRSAAVHLLRPMEQGAFIVRSSSKSNAMALSIRLPSDFDADIDHYLIESIADRTVRLESSPNNFKSLPLLIEHYCLNGEELQTCLALPAVIASCRTSVQLQSIALMGQEEILTISQKFDRKRREDCKQMSSLTCIALFTYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1C3</accession>
    <name>A0A0N4U1C3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4756</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1C3"/>
    <dbReference type="WBParaSite" id="DME_0000039601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000039601-mRNA-1"/>
        <property type="gene ID" value="DME_0000039601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000039601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12932" checksum="5A5B8850034C8C31" modified="2015-12-09" version="1">MPTVVDDEEDFWRQPLGSWINGFIVTSDFRDCVSGCDPLIPESTWRAVDRQGSKLRFIDICDGYVFNLLFVFVVHLKLDFYVLCDCQCERQYIQRVRELTRALGVLWKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2H8</accession>
    <name>A0A0N4U2H8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5243</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2H8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2H8"/>
    <dbReference type="WBParaSite" id="DME_0000088301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000088301-mRNA-1"/>
        <property type="gene ID" value="DME_0000088301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874796at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000088301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10914" checksum="0B223C92903B8D62" modified="2015-12-09" version="1">MVPLILGAPDINFPRLNELLYGGHPGNRVDLAIFSLHCSGVKLLELVVVWAHHIYTVGMDLDSHAYFSAATIVIAVPTGVKVFSWLATLCGIGMVFQPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2P4</accession>
    <name>A0A0N4U2P4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5324</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2P4"/>
    <dbReference type="STRING" id="318479.A0A0N4U2P4"/>
    <dbReference type="WBParaSite" id="DME_0000096401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000096401-mRNA-1"/>
        <property type="gene ID" value="DME_0000096401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000096401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52657" checksum="D5AFD25A1EF91220" modified="2015-12-09" version="1">MQNQPNVWYRNGKIMQSSDSPCRTSNLADFFGYLPSRDGFNNWHGSWKNSFPIHHQNPPSLRYEQIPYPNFTYPQKHFVTNSVSLRCGDLAIPPWYLSELKERNIKMLKERRMRKKLEGNKSTPCQAWKDTGRCNFGPHCKFAHDEIELKEPEHQPMKIYVHPRYRTTECKNYQYLKDCPYGESCCYIHGTTKPPIDLEKQIEKLLLTPINTSPVREKELRNDGTRSLTGNTTTNISSPAEINFANRKRYYNSHTAELNQACIYYSNQRSNYPRYILPAEYGNTELFSGSTGINYHRRMNLPAFETDAVRNEKSLAPCLPGISLTPLRQSAYPNLLEFPRFKSSSTVEFFHRNPNTASISFQPNSICQSANQHVFEIENAAKLQMQNIYHTDKTQLQQNFRVNRVVEENRKFGNTEKYDPLKTNAAAQEEIALQNNRILQALFGTSDIAYNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Q6</accession>
    <name>A0A0N4U2Q6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5337</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Q6"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Q6"/>
    <dbReference type="WBParaSite" id="DME_0000097701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000097701-mRNA-1"/>
        <property type="gene ID" value="DME_0000097701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="151"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000097701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54177" checksum="603473DD0D9CAC8C" modified="2015-12-09" version="1">MDRLRESASVPDLSTKDIHHSSFLWDNTTKIATKTTSRIVEAASNFRSLFLPRQHAEEVPTILDDRILVESMSYRQAFDTAWSKIKYNGWLLWHSDKFMKESSIWLLGKFYKINNPGGYMQNYFPPKFYFGDLLEGSKEVIGSDESREIFQKFLEDFRSRIWLTYRTGLARFPASNSTTDSGWGCTIRSCQMMVAQTLILLNLGREWRFFENLNSTRKCKDDSHLNIVSLFSDDLDSDLGIHRLIHLAISEKSNAVGCWYSPSVALSLLQKALLNSTSNVTNFLIMHNVIDGLLVKKDVVCASNNFARPVLVTVSVRLGTDSINSCYFNHIINFFSLKNGVGIVGGRPRHSMYFVGAYGKKSVIYLDPHTAHYALSPSKLSNSYGTFHCDHPEKLPLEDIDPSCSLGFLVRSEAEYDTTIKELNEIHFIETEVQKENGFHPIFTALKDYPPMLKTFEISERYQNVHVDQDFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U313</accession>
    <name>A0A0N4U313_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5458</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U313"/>
    <dbReference type="STRING" id="318479.A0A0N4U313"/>
    <dbReference type="WBParaSite" id="DME_0000109801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000109801-mRNA-1"/>
        <property type="gene ID" value="DME_0000109801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000109801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34207" checksum="9672AC4E4A5DAB8A" modified="2015-12-09" version="1">MASTKRGSDEGVALCLSVVLLGIKGLIGHIEGRKEEMVFNNDAKRLFGTTNLYEILQLHGSKKVRQNYTREEIKKAYLKLTLKYHPDRCYGDNEKVEATQKFQILNKAYSILDNKEKRKIYDDTGVINDEEICYNDVDLSTLWKAAFKKITKADLESYIKEYRESGEEREDVKKSYENHKGDMGKIMNDIIGVSFEDEDRIRNMINEMIENGELKLTKSFVNESRQKRAKRQKAAKKEAKEAAKMLKEIEEKEGSKSLVALIQDRQKNKMNGYDKFCDELAAKYCNKPASRKRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3U1</accession>
    <name>A0A0N4U3U1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5764</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3U1"/>
    <dbReference type="STRING" id="318479.A0A0N4U3U1"/>
    <dbReference type="WBParaSite" id="DME_0000140401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140401-mRNA-1"/>
        <property type="gene ID" value="DME_0000140401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805553at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="934" mass="107365" checksum="7C9766B71718A2D3" modified="2016-06-08" version="2">MKRLRGDLLGDENLIKKRKQSHTRFTPFKPIKLPEAWKYECRKMQESIRYALSNCQYSDPERKERLFLAVMDALSGKKTIKGAAITHNVVIPCTTLQVYFHRSRLHMEKLMNDHDSGIAEQIEIPVSLSLFGSLVHDDSSANEIVAPRENLALSSVSVDSCECLINKASCSKSLVRTITGSKKRKPKSVHRFIPEPYFCLDPETEKQNYDEFFDTSKNIYLIHMSIGDNLRQLRIPNKSSEQIFAPEASSLDNNDLNSRRTQNNSPYIRNAIAAVLSFSNAPNDVKNRLKWAIMDIQRKKLTIEQACYQYHLLNDCLIAYNQMVEKIVDEKDKSGQSCGNNLEEDCRIIQWSKFKIADKNRCEVGLPLDPKDHERKEKIENCVASVCQASVYPMKMKVICGEQTISAAAYLNHLPISTVYTYVSRARIALSGILPPQITGSSKLPKKLCTRDRNEELMVNNSRKMNEIDKMLTLLLENSNFNETYKQKIFHATLMEPFVYYIFQQVICGSIVVSIIEGASLVMASKLCGVPINSFNFYVQKIRYNLQLSSSLNKISQKENMIVAKCDSTRANISVENFKMIETPSNSSSTPIERTFLLSTANTDTIFRSKKIGQLIKRKNIMNELRPSNSDSCSSPPYEFVCKNNQHPVDDEYELFQNVAHYMCEDKFDEITSMDINIQPRLKEKIYVILRYYNYTGNHDDMCNALLEVFVERKNCDEASSSKTFSSRTLSTYVRLVKALLIAVNKELSDEQSLKLQICETDMDEMMKDNDIMLIHSKSILNSLEHSIKLIISYLVEHRCHQSQDLQEKRQRHALSFEKKILKHQKILDILTNSLSEKDFRKKSTTPSSKLNAINFPIENRLIIGLAKEICSKLFIFPEKMNIPDTVWNEWATLYRQLHPEPYSMHNITLSLCIKSTTRHALQKAALMRREANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4B5</accession>
    <name>A0A0N4U4B5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5977</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4B5"/>
    <dbReference type="WBParaSite" id="DME_0000161701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000161701-mRNA-1"/>
        <property type="gene ID" value="DME_0000161701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810123at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="1">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000161701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41705" checksum="FD8F3FB81EB35E9F" modified="2015-12-09" version="1">MVLLYTFPRCSSSSSLTIPLAQEMRETLPITGHFDSVDLSNNNYTNCYNLHESVNESKFEFGNISAYKLPFYKGFYSFVTGKDHRQIYKQMEIDSEEEDDYSERPSTTSVENYSVIHRVNEAKRITDENLRRKVLKLSTSKIQTISASNVSTSLRKSVLIINMMKRLQREIDLCDVDVYDSLREESTALAVYIDKEDQENEEREKKEIKSLWQSGECYVQQGNNNYAINTSGRFNYLNWPWSDGQSVFSATNDTFQDLNADNSIFLEYVQCAIKPSNETTTSKEISSSCAAFPLPSNATNISGNDALCRKTSENDYVEEYIDMWRKWEENNYNPLVDCNLSQFDIINLFGLPSVNNRVILSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4C5</accession>
    <name>A0A0N4U4C5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-like protein OV9M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5987</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4C5"/>
    <dbReference type="STRING" id="318479.A0A0N4U4C5"/>
    <dbReference type="WBParaSite" id="DME_0000162701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000162701-mRNA-1"/>
        <property type="gene ID" value="DME_0000162701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF11">
        <property type="entry name" value="PROTEIN UNC-87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000162701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42056" checksum="F1EA85183FEB3360" modified="2015-12-09" version="1">MADVDEEQMNEENEDVEEQNEEEHVKPPPPVDIKSPTPGRSYGLPSQPKSVVRRAAQFSAGKPSKHDKDKLMRSEGIIPIQAGSNRYASQKGMTGFGAPRDVIDKVKADNLAEITDEEKIKNLKQSTWLQSGTNKFASQKGITGFGSPRDVNYKTKGTGGASEVPEEKARATDGIVPLQSGTNKLASQAGMTGMGMPRIIDVRKTNDQDRESQGFIHLQMGTNRFANQAGMTGFGMPRHNITKYKDEQRGEMPHDESVISRQTSGWKEGASQAGMTGFGAFRNNTVLNMQAQEQRSQGMIPYQMGVNFLDSQAGKTGFGMPRQIYTPFVDDGHEELPLDMARRPEVPFWSGQETEFANQTGMSAFGTIRDVRGEYIRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4D5</accession>
    <name>A0A0N4U4D5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5997</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4D5"/>
    <dbReference type="STRING" id="318479.A0A0N4U4D5"/>
    <dbReference type="WBParaSite" id="DME_0000163701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000163701-mRNA-1"/>
        <property type="gene ID" value="DME_0000163701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="118"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000163701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60201" checksum="F46D920EF9A61782" modified="2015-12-09" version="1">MMVESNLHGNCLPPEMEEGNIEYKMKLVNPSPTRIQHLITQMKWRLREGQGEAIYEIGVEDDGTMVGLTDDELNASMNTLRIMVNALSASMVISKSKKSSHRRVVEILVRKVPDNQQFIDLRLAILGGIDVGKSTLCGVLTQGVLDNGRGKARLNLFRYLHEFQSGRTSSICLDVFGFNSKGDLVNYSNHSLDEIVKESTKLITLVDLAGDRKYLKTTIYGLSGYQPHFAALVVSATKGPTSVTREHLGLAISLSIPVFVIITKIDLVLNSQDAVGYLIFILSKIFFEHRIFFLPLNYVYCRYASSMISQNIVPIFSISNVTNQNLDYLKRFLNILPASGMSISKRDELSLAAPLFCIDEVFSVPHVGIVVCGLMNDGMLSQYDRIQLGPDKKGMFHIGKIDSIYRNKQPVRYVGPGEAPSIAISLTEPDALAFEDIRRGMVLINWKDIGVSCRRFVARFYLLYHTSEEICIGFQATIYIGSVCQTATIIDLDCPSVIPCVWVIATFEFYSYPEFVRTGTPLIFRQGPTKGMGEVIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4X6</accession>
    <name>A0A0N4U4X6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6228</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4X6"/>
    <dbReference type="STRING" id="318479.A0A0N4U4X6"/>
    <dbReference type="WBParaSite" id="DME_0000186801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000186801-mRNA-1"/>
        <property type="gene ID" value="DME_0000186801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05166">
        <property type="entry name" value="PI3Kc_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="344"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="661"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="798"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000186801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="975" mass="112566" checksum="D5B358940DC9892F" modified="2015-12-09" version="1">MSIVVFHNEDVGREFSISQVLCIREWKNTINYLLYMVDIKYSWSLLYEEPETSYSSWKFPPHVPFGIRMDPSYFKLSNVFIIRKLEMLQQIPITTLEGNNCNPPSRERKIFKVNNSFGRSTLSSDEKEILWEKRSFLMHIPDALPLVLASAVAWDWASLNNVYQLVDDWIPLSPVQSVELLLPHFADVVIREKALTWLKSASSDFIFNFLPELVEALRFEAYENSALAVYLITLCAGDRRLAFELYWQLQQRINHLRERPFRNRCKLLQNQIFQILDEEFRLDIQNQHHLLRILNSISENMKDSSESSKMLSILHRNLSLLDARILENNVRLPILPSFLCTGINVSESSFFNSLTKPLKIVFKGLKTSYSILYKIGDDMRQDALVLQLVKIMNDIWLSQGLDLKMIIFRCIPLSARTGMVELVPSCRTLCEIQKSVGATGVFKDDLLKNWLQMQNPTEFQYKIALENFQLSCAGWCVATYVLGVGDRHNDNILVTTKGHVFHIDFGKYMGDWQKAAGFRRDRVPFIFTSDMAYVINDGSSQSATGRYQLFVDNCCKAFNLLRKKYSLLVNLMKLVTCSDIPGMDMEAVNFVQSNLMLNLTDTQATVQFTRMIEESLKSKFPRLNFFAHTLVQLKATPSMIYGGFDDPNKLSFVPQLYTEQEEGRIISVVVLSFEKWHMPDKMYKLEVRRVNETVSSIIYRSFPEFSELYVKLCRRFPIAALPALSRTSGMGRSNIRSVAERRQADIQQFIFLLFDQNDEIAHCDLVYTFFHIIYRDSAPDESNKLAISNVDCRRIALITGSIFLRISYCKQQCTLNIFVGHVKGLKTINRQVPDSYVKTYLHPDPQRISKRKTRVVKNTQTPTFNEEFRDSHSLGLLWPSLFASQVIAISVISVSDSYIRYLVDWPLYYSTVNEKMLSEKALEVSVWSCGSIVGENSVIGSVHISLKRLNDVQFDRKGIKTIDGWFKLNGYSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U540</accession>
    <name>A0A0N4U540_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6304</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U540"/>
    <dbReference type="STRING" id="318479.A0A0N4U540"/>
    <dbReference type="WBParaSite" id="DME_0000194401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000194401-mRNA-1"/>
        <property type="gene ID" value="DME_0000194401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000194401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53146" checksum="C5630360E20A0C77" modified="2015-12-09" version="1">MRVRINNQKKEEEAAQRKEIIRKRERAVEMLKEQQTTPLKSCLHKSPARLAPFHKQINIKKFDQTSIYSPARKVFKGSVSIKIDNSRAVGLCSEENDKTRFLESTSEQSGEQEEITSIKNTLSYFEATKQSKFSVAPEPQKFGIDKSPMVIRLKTVEDKDNLLEIHQQINTVHKKSSSGNKCSDKIRNINESLTLHEEIDEKEQIESSLSSVYNKENMSDGKTAPENNLIRSISNLEPKKYGGTALCDVVPKAITVDPSSSQCTKSKTEITISQPVISENYDIDDMSSGDETDDENNPKKPIPDWAQFERLENALREQIGHPPITDDYFGPILEPDLAKIFARNRVCYDKRTSSALWSSPMNNPTRGSQEITLFGYVGVNHELCDFSLISKELIICRKIRTGIAVMDSVSDTCWTGWAHSCLVKPDEFHWGISWWTGKQPGSPLKNSERKHQHGHSETTAVHTVPQHGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P7</accession>
    <name>A0A0N4U5P7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6544</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P7"/>
    <dbReference type="WBParaSite" id="DME_0000218401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000218401-mRNA-1"/>
        <property type="gene ID" value="DME_0000218401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000417">
        <property type="entry name" value="Even-skipped homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000218401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27496" checksum="BC5A59C579C8D076" modified="2015-12-09" version="1">MFSSIESLLQKSLPKASSSQFSTKNSTNNDLIQPIKQSSSNQPFASLNQFDIPSECFKSSDNSNRSLSNSISKKQNSPINFSKPNLNEFLYNSQERSATSTIPHLTPSTTLNSCDSFSEANSFISNQSSPKPITFAISPRLFIEQLQYPLNTSLPLLYDHIALTIGAWQTLGKMRRPRTAFTSEQLIELERNFAESRYLSRPRRYQLAQELNLTETQVKIWFQNRRMKNKRSLINTNILIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5R8</accession>
    <name>A0A0N4U5R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5R8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5R8"/>
    <dbReference type="WBParaSite" id="DME_0000221001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000221001-mRNA-1"/>
        <property type="gene ID" value="DME_0000221001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000221001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32669" checksum="EC41BF440D5E440A" modified="2015-12-09" version="1">MAVAVSKVGIPTWIVKVRHKATHQHMPSLKMFRKAARFCRQWLWIFIYRFRDFLDTLLLDGRLIMTQKQIQMAGFSLSVSDSLIWNIPETLQRFWQPVFHILSRVRALPELLYGLVSALDDPCNSQIRDRQLIAWIHLLLSTLCKSDIVPNSDWTRIIRGMLRVPQKYLDSHFEKVLNKLESGGEEAEKCKCLRQLVNIALGNNFEVEENETCTNEENRPVRTVEDLQKLLSDDPSLSAYYDANNGQSNWILCNANDWKEIPLGLTPEQTTESLCLIIDPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5V5</accession>
    <name>A0A0N4U5V5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6621</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5V5"/>
    <dbReference type="WBParaSite" id="DME_0000226101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000226101-mRNA-1"/>
        <property type="gene ID" value="DME_0000226101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000226101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7586" checksum="E006B3C873641525" modified="2015-12-09" version="1">MNSECFFVILSKNQYDRVSVLRCNIGNTISDDGKFAVKDDPIEDCPAILCRNGSNSIGSGANQTGNHDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U614</accession>
    <name>A0A0N4U614_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6689</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U614"/>
    <dbReference type="STRING" id="318479.A0A0N4U614"/>
    <dbReference type="WBParaSite" id="DME_0000232901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000232901-mRNA-1"/>
        <property type="gene ID" value="DME_0000232901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856134at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000232901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18207" checksum="954238004FE478F5" modified="2015-12-09" version="1">MLRMNIARTEHNNNRLSATSAVSAATNGAISGVATNGAAFHHTPAAQVIINGITDERGNLRQSSSQHYANGSAIDVKDIIGNHALKQGSFMGLSYHQQQQQQQQQHPQQQQQQSVSSSAAANQTHLQTESSDSTTNTSATGRNRHRSSQNDGFIKCHYCPKKWADQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U698</accession>
    <name>A0A0N4U698_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6792</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U698"/>
    <dbReference type="WBParaSite" id="DME_0000243201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243201-mRNA-1"/>
        <property type="gene ID" value="DME_0000243201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803839at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="33262" checksum="C55A10D7CFAD2B47" modified="2015-12-09" version="1">MRWCCFKFWFIYRLMLAVLAHFNWIIAIYVNCIYFWLWKSYDLLWFWMHLILSICFKPLRKENYLLVWCNLLIKRCRSDYRFTSYRVRFLPPFLSPFLSPFLSEKHVLKREKQDRKALTKKIRARRKAELAIIARKEAREKALSNAIELLLQILRMIASFAILVGNIRKTFIPAQFKWLKPGQNAYDNPELLILFRFTVFLDVVLFWMNILWTNCLQCQLCCRLGIVKFWLWSLVLATVGGVFMIMPMIYVQKNLDISWCRLLPNSSLIRYQPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6B8</accession>
    <name>A0A0N4U6B8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6818</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6B8"/>
    <dbReference type="WBParaSite" id="DME_0000245801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000245801-mRNA-1"/>
        <property type="gene ID" value="DME_0000245801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000245801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17723" checksum="5FE3E14157413820" modified="2015-12-09" version="1">MPLPEDSSLCQAYWFGFCHSESVVKNLHVDEDLSTYLSLNGSMIWGCKLEKMAQEEAEKRADKNDCDAKTYLQSHRSIEINETSKGLATILFVQEEGMHKMVKNLYSDSILHKSTKDLAEIKKIVQEKNRVGCGIGVCSNIKGPVTLYLVCKFNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7N9</accession>
    <name>A0A0N4U7N9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7168</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7N9"/>
    <dbReference type="WBParaSite" id="DME_0000300901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000300901-mRNA-1"/>
        <property type="gene ID" value="DME_0000300901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000300901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8555" checksum="DB8E285703391EAC" modified="2015-12-09" version="1">MLQPVIDSLVESLCINPTNCRATTSASVDSWVHENWFASKLRPLASNFLFGLASHTPVLTNEKDFEEFARSELSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U869</accession>
    <name>A0A0N4U869_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS7379</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U869"/>
    <dbReference type="STRING" id="318479.A0A0N4U869"/>
    <dbReference type="WBParaSite" id="DME_0000322001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000322001-mRNA-1"/>
        <property type="gene ID" value="DME_0000322001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000002">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000027">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="183"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="13">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN57406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000322001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52623" checksum="DBD7C2520AB55670" modified="2015-12-09" version="1">MVLDIDLFREEKGGNPKLIYESEKKRFRDVKHVDNVIKFDVQWRQKRFEADNLNRVKNVCSKVIGEKIKVRHFIFFNELTIMQLKFLSGIINEKITEVKKEMDKLEVIRHDSLIQIGNIVHESVPVSDDEENNRVERIFGDVKSKKKYSHIDLTIMIDGFDGERGTAVAGSRGYFLKGPLVFLEQAVINLALQTLHAKGFMPLYTPFFMRKEVMQEVAQLSQFDEELYKITEKSSNDTGEEFFDEKYLIATSEQPIAAFHRNEWINQADLPLKYAGISTCFRQEVGSHGRDTRGIFRVHQFEKVEQFVICSPHDDISWKMFDEMIANAEEFCQLLGIPYRVVCIVSGELNNAASKKLDVEAWFPGSAAFRELVSCSNCTDYQARRLKVRYGQTKKMDGEVLYVHMLNATMCATTRVLCALLEIYQEEGGIRIPDVLKPFMPPKYKDFIPFVKAAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U875</accession>
    <name>A0A0N4U875_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7385</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U875"/>
    <dbReference type="STRING" id="318479.A0A0N4U875"/>
    <dbReference type="WBParaSite" id="DME_0000322601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000322601-mRNA-1"/>
        <property type="gene ID" value="DME_0000322601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="117690at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000322601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54188" checksum="49035C0EE4A5BB5F" modified="2015-12-09" version="1">MGGSTMKTAKVWRYFDQLPSEQQAATCKICYKKIKATNSSNYQLIRLSDNEVSFSTTGMIRHLRSCHVNEYQILQEARQNGLALKLEEKARANVMKQLNDSQKNLQQQRQRETTPHTIVNIIAGTLQKKIKTNVSNCSSIKNEVYECSEAKKAKVNYCNDAIDLTTHHLKKEANDQTNGTLNGKNENYWPDDHPEARRITNQVVIKYFMNKFLFPVGLMLLLDNETPNAVDRTGFRNLLRLLEPKYRMPSSEKFQKIIIPQIFNEFKLNVASFQYQQRFYENNFFGIDRMANEFFKNSDTRLYNETFGQFAFPQSCIIQPNQDEMNRVIINSIRSAQNISQSFSHSIQLCDEDSDSSADSESLLTTRIESFLERIGKYVFPQAEIAELITRCYSIYHYFEDHSDDTSQILPGILTPSAIIDLAKCVDFVHKNLSTIEALNLRHPIPSFRQFTQKEIQLLSDLNAYIHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U935</accession>
    <name>A0A0N4U935_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5 18">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 18">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS7584</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 18">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 20">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the SepSecS family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="5 18"/>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U935"/>
    <dbReference type="STRING" id="318479.A0A0N4U935"/>
    <dbReference type="WBParaSite" id="DME_0000357901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000357901-mRNA-1"/>
        <property type="gene ID" value="DME_0000357901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263545at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098621">
        <property type="term" value="F:O-phosphoseryl-tRNA(Sec) selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001717">
        <property type="term" value="P:conversion of seryl-tRNAsec to selenocys-tRNAsec"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03531">
        <property type="entry name" value="selenium_SpcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10 18 20" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18 20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 20" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
        <ligandPart>
            <name>tRNA discriminator base</name>
        </ligandPart>
    </feature>
    <feature type="site" description="May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate" evidence="20">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="20">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN57611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000357901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45202" checksum="2D32F69FADABD411" modified="2015-12-09" version="1">MSEYGRILLTLAECCLMKTAQGKVPEEGLQPHVVHEFISRLASMDSNNRFDMIKVGAGEREGRVVSHTVNQLHIGLAHGIGRSGNLFEKQPKASGSTILGDLANRLVLDAIKNLGITCANYALIVPVATGMALMLCLNAWRRLKPLAKFVVFLRIDQRSCFKAIIAAGFEPIVIDCIKHQKDECLTTDVKKLQNILEARGTEILAVMSTTSCFAPRSPDCIVNVGQLCKAYSVKHLVNNAYDAVVQSLDKNFLVPVGGAVIVTFVKDDIASISNVYAGRASIVPSRDLLITVLELGRMGLQRLYSVQEKNFIVLRDHLSEFAASIDERIFDVPDNLISLAMTLSKWTKEQQFELGSALFKRGVTGARVILSGMNKCVDGYSFENYGSHSSLTHCGYLNVACAIGKFESDLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U945</accession>
    <name>A0A0N4U945_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7594</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U945"/>
    <dbReference type="STRING" id="318479.A0A0N4U945"/>
    <dbReference type="WBParaSite" id="DME_0000358901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000358901-mRNA-1"/>
        <property type="gene ID" value="DME_0000358901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000358901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12983" checksum="DEAA5D223CF31AA7" modified="2015-12-09" version="1">MIPFSGTVSGLMIDFVADCCGLNDVIRVENIQEKIQSALEEYCRTQRPHQIGRFGRLLLRLPTLRSISPNIIEQLFFVKLIGKTPIDFLLRDMLGSQTDNLIKPFIWPHQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U975</accession>
    <name>A0A0N4U975_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7629</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U975"/>
    <dbReference type="STRING" id="318479.A0A0N4U975"/>
    <dbReference type="WBParaSite" id="DME_0000362401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000362401-mRNA-1"/>
        <property type="gene ID" value="DME_0000362401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868581at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000362401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13923" checksum="22329AFF0F343E38" modified="2015-12-09" version="1">MYTFLDDKIAWPEAPEKCLGTRLSKQERNRILNFHNQKRSELARGLIPNKSGRKMPKSKNMRSLKWDCDLELLAQEWSEDCFYKNSPKSLRENAGENILMIANSNAMNQSKFEFYQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U986</accession>
    <name>A0A0N4U986_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7640</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U986"/>
    <dbReference type="STRING" id="318479.A0A0N4U986"/>
    <dbReference type="WBParaSite" id="DME_0000363501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000363501-mRNA-1"/>
        <property type="gene ID" value="DME_0000363501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="346"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000363501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57454" checksum="9BFBD2626AB8A7C6" modified="2015-12-09" version="1">MLRNSNSLPAIANLSTSIDFGRFGKRAQIFDSTDAISSENFSINICLSIPTTESLMQRSVAYKASNQASINSNSSGDHHNIILHNVGKTIHRTHNHLRRTRLLHIFYFITLLIYTIIGALIFQTLDGEYDDALKSIYEKRCQADRKFKMESLKKFCNTHSNRCYDKMISFLNDVEHCYRAWHEINRTVLHPMSDFSNAIVYAFSVYSTIGYGNMAADTVACRIATVIYGAIGIPLFFAFIKEEGAFFRLCFMRLYNFIKKYKFNRKSLINFGNRAMKINSKLIRPENASMLKQSSSVTIFLEKASDPKNDRRKQLAIDKFSFGSSKEGYTSILEQRRVFFAGVFIFLAYLLAISGLFSVMTDWDFFTAFYFLFSSVALIGFGDIFPSSSKVVLINAFFITFGIILFSMCYFILQEEIREKAFEASKKARKSISKYSQNLIQHTRNSWSRNTSSGFDAQEMNVIGDRCQEISVKTPFKRNRKRRQSAPAFSLTIPSFNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9C2</accession>
    <name>A0A0N4U9C2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7678</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9C2"/>
    <dbReference type="STRING" id="318479.A0A0N4U9C2"/>
    <dbReference type="WBParaSite" id="DME_0000367301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000367301-mRNA-1"/>
        <property type="gene ID" value="DME_0000367301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041080917" evidence="2">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000367301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47837" checksum="EAC61BED52F2E0BB" modified="2016-06-08" version="2">MVLLLLLCLTSIWSNIIAFNFTVICMRHKNSEPNRNLKDESVNALENYSSIKNASHSAYFTPTERTYLTSIVAAAALIANFPLLYLVNKFGVRVIFTILGFISAISTCLLPVAACQNLYFLLATPNFIVIGAFTSSWTYYKQNGLFVSVLVAYVQLSPALTMPVSGALCSTSLDWPTVHYMHGILCIILFIIFGFFYRNSPSKHPFVSEHERKKIAVGKTEASKAEIKRIPYKAIFRTWSVWAVWIAAIGNFTCVNMLFLYSPTYLYRALNMEVTKTGFAAALPPLMQFLLKLFAGITSDKIKFLNERSKLWLFNSIAFFGCAFFLLVLSFINASGKNIAVFCLGAAATCLGLTTGGFFKAAPLISKHYSHFVTGNISLVPSVVSGLAPNNTVSEWRQIFIATAVVLVVTNIFFCKSLKCENAFLFNLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA41</accession>
    <name>A0A0N4UA41_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS357</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA41"/>
    <dbReference type="STRING" id="318479.A0A0N4UA41"/>
    <dbReference type="WBParaSite" id="DME_0000399301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000399301-mRNA-1"/>
        <property type="gene ID" value="DME_0000399301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000399301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12289" checksum="FAC1D48A59FE3FA5" modified="2015-12-09" version="1">FIYFASSNERISKNFIFFIYILYAKTFWKKVFFFCAIPSMLLTAYGAKKIHDKEGHFDQSKYVEYPYLNVRNKPFPWGDGNHSLFHNKKTQFTPGIGFEEKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAR9</accession>
    <name>A0A0N4UAR9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8146</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAR9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAR9"/>
    <dbReference type="WBParaSite" id="DME_0000426301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000426301-mRNA-1"/>
        <property type="gene ID" value="DME_0000426301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829461at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000426301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40376" checksum="100FE10F7A6AB819" modified="2015-12-09" version="1">MYTVRGLGGKVRKEAAHREGSFQRDVREVRSGQSERMRGQAKYHGEPGSARRLMEVFPKAYRIDLCRGYCSKSMESAFISLEIQVSFISPNNYNLQFKGEPLWINLLMKAAKKSDNVRVFLTNTWKETFERRYPMLAKFDMHFNEVDSIYDIDSVKLESDGNRRLAYFIDSIDRDFLDFGEKIVAHLAQLSRKNLVVTRIYSDVVSNDGWKSLISIANTTMVLYSDEKERCICSWTHFKKSGDRQSKKEFLTFDNCLNLHCSPYLPSATSEKTIGQMAPTTTFDMGLSLSKAEHIAKESVKLPYLMAQDEKMLAEMDISSNKKIRAGGRIIYTPDERDDFDDSDLDDDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAU6</accession>
    <name>A0A0N4UAU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8180</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAU6"/>
    <dbReference type="WBParaSite" id="DME_0000429701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000429701-mRNA-1"/>
        <property type="gene ID" value="DME_0000429701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825164at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000429701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17850" checksum="0DE0743D2C173727" modified="2015-12-09" version="1">MGLCNSTFIIHLLISINRYFSISFPTSYSSIFTKRFSYSSIIVIVLCTLAIRTTNFIGDFIAEFIVEFHSLAFLFLRSSNATAVSIALLGLSIFNYIMNKFGPGWINSGLSSAIWISFHTLDGSVYSLIPEIKQFSEKPSFVSKFQGCFFDIQCQKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB39</accession>
    <name>A0A0N4UB39_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sorting nexin-27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8282</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB39"/>
    <dbReference type="STRING" id="318479.A0A0N4UB39"/>
    <dbReference type="WBParaSite" id="DME_0000439901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000439901-mRNA-1"/>
        <property type="gene ID" value="DME_0000439901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036828at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="265"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000439901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57554" checksum="3D22CA7764280A66" modified="2016-06-08" version="2">MGDESDSSEECSTPIRYRNYNPNPHLVVIVKSEAGFGFNVKGQVSEGGQLRSINGELYAPLQHVSAVQRGGAAEKAGILKGDRILQVNGVNVEGATHKQVVELIKEGGDKLSLVVISVNALDAERFEGGLIEETGSSYRYDYSEKRSLPITIPSYQTVRANGERFVVLFILLPAYNIHMAGRHLGSRRYSEFAHLHSLLKREFADFDLPKLPRKWPFSLSEQQLDSRRRGLEMYLEKVCAVRVIADSGIIQEFLMEDSSSDCSVADVHIRVLLPDNSSLLLNIKRHCTCKQLYSLVVKRLNMTNEMAECYALFEMSDSNFERKIDDNECPHALYIQNYSSAASSCILIRKWIFDIDREIALCEKNDLFNQFCFWQAVSDVNSGLIHARERLYHLKALQSIDRSHEYLKIARMLEGYNQITFPHCICDGRKNGSVILLVSLLQLLIRACDSEGNLEEDKMVIDWNSVIEFSVSDEGNSFVFEYTRPTKKSKWLTFTTPFVSFFIYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB47</accession>
    <name>A0A0N4UB47_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine zipper transcription factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8291</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LZTFL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB47"/>
    <dbReference type="WBParaSite" id="DME_0000440801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000440801-mRNA-1"/>
        <property type="gene ID" value="DME_0000440801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="313412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903565">
        <property type="term" value="P:negative regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026157">
        <property type="entry name" value="LZTFL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635:SF0">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15294">
        <property type="entry name" value="Leu_zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000440801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16313" checksum="39D4AAA28852DB52" modified="2015-12-09" version="1">MNLSELEDRELLDAVRIFEDEHFEQKTTKTATILQKLVALEGTIQERAERESEGIIQMRNMIEALVVELDKSKTENERHQMNQAKLVEELLSLKEEELEKKFEATNAYKTMKQILKQKNYQIKQLRMKNANNSGDSDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB95</accession>
    <name>A0A0N4UB95_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DCB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB95"/>
    <dbReference type="STRING" id="318479.A0A0N4UB95"/>
    <dbReference type="WBParaSite" id="DME_0000446201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000446201-mRNA-1"/>
        <property type="gene ID" value="DME_0000446201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10002886at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000446201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23872" checksum="70A94FD9FD48C9E3" modified="2015-12-09" version="1">MLNREGDDMNIVVLRAKCLNVIHMALKVKHGQLNPIAMDALQAFIRDPRFESHGTVENESDTLVMQVLKTINPLESWKPHFQCRILTIIIEMMCNPKKRISLTIIKETIQMCSKVYGNAEETSVRLAARAAVAQIVSSFCSTANLPEEFVAQERIAIFMDVTALLDDTVKNIDKLGHQTERVVILLDTVYCLLSVQPISIQTHQPFINVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBN1</accession>
    <name>A0A0N4UBN1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">I-set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8504</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBN1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBN1"/>
    <dbReference type="WBParaSite" id="DME_0000462101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000462101-mRNA-1"/>
        <property type="gene ID" value="DME_0000462101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin I-set" evidence="10">
        <location>
            <begin position="188"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000462101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57262" checksum="D42419058B64556C" modified="2015-12-09" version="1">MGQGQGRFMIISTMVLSLFPTIAFLVIYRITINFTNLPYPANSRHTNPQRQATIDRRITEDIDRLLKNIPGQHKIKLLPYRYHQVVGTLVTIDLYSTSRSPKIRSAFENAIHNGHLGRFAVGPDGYEFHILKDSLKECTSSKFQCSDETCIDIAKKCDGVNDCSDASDESPEYAKCKKLAVYLSLEESSLNVGINETIRISFTIHGSQNTTNVTWFHKGKRIAQNGNAIRYDPRISIYYSVDRQILQIENAIETDAGDYKIHLDDYSVEKTVNIKIIYTANTTEESKCPSNQFKCPSGHCFPKSLACDGYKHCPDGDDELCTSKQFHCVQDNECIERTARCNGLNDCKDGSDERNCPKVTVASWRRSLPTVRCPDGSYPEHSLHGSTYCWSNSVCPSYSACIDSKCCTTNLALQKLLLNCSSSFIVLKELRLCPTSQWECGDGHCLRAEMRCDRVVQCKDGSDEMHCGMVFKNFFFFFVIFMTDLWKKNSVKNIIFEIFQFFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ4</accession>
    <name>A0A0N4UBZ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8639</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ4"/>
    <dbReference type="WBParaSite" id="DME_0000475601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000475601-mRNA-1"/>
        <property type="gene ID" value="DME_0000475601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000475601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13072" checksum="527945C4DCBD5F28" modified="2015-12-09" version="1">MPFLSKTLIEITIAKLILQEYFQEDFHFTPYSIISYVLLGRKTMINKSNESHKIIFDIPKWTDLSLNQDINSMKKRKQQNLAIQITNKRICSKQYGSNTLNDNDNDFILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCF7</accession>
    <name>A0A0N4UCF7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Defensin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8749</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCF7"/>
    <dbReference type="WBParaSite" id="DME_0000495001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495001-mRNA-1"/>
        <property type="gene ID" value="DME_0000495001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16664" checksum="95AB58C421997902" modified="2015-12-09" version="1">MLNELINDSGCRLVGSSCGENMVLEIFSKLNGSCVDKCVCAYNSVENDIGCVKCDWEEEDVDDADDNNDDSDNSVNDGGVDDNAYLTARKEYHLGEEISDLGCRLRNHECGINKKFIAVEEFSTEHDPNIKGCIERCSCILAEAGDCMQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCP1</accession>
    <name>A0A0N4UCP1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3Beta_HSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8843</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCP1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCP1"/>
    <dbReference type="WBParaSite" id="DME_0000504401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000504401-mRNA-1"/>
        <property type="gene ID" value="DME_0000504401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000504401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42474" checksum="350B21ECB51D4BFB" modified="2015-12-09" version="1">MVVNKEIVGITGGSGFLAQHLIAYLQNNSTATVREIRIIDRRPFKKFLDYPSSIPISIFILDICNKDELSKSFESCTTIFHCAGKQFQYIHINEDIDEQYIHDNIDTTENVITVMIDQRIRNIVYVSDAYAHLPRCDNYGHSEQVHINIPENFMLGSYGESKVRAESYVMKFARKNMISALILRPTFIYGEGESHLTSTAFNFCQKFQGFPYICGNNRGNHQYIYAGNMAAIMERCMNCLRSDAMKYNGEIIYCIDATSCIPFRDFIIPYLEARNFNPTSTMSYMKAFLITAFYELLNKIYMEKSINRLTMQAFQFLNGWTVGFSNRKLRLFLDFIPPFEQSVAMKKSVAWHKENINQAIAIERPKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDU5</accession>
    <name>A0A0N4UDU5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9261</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDU5"/>
    <dbReference type="STRING" id="318479.A0A0N4UDU5"/>
    <dbReference type="WBParaSite" id="DME_0000552001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000552001-mRNA-1"/>
        <property type="gene ID" value="DME_0000552001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF105">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000552001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="53686" checksum="7968D681C3502961" modified="2015-12-09" version="1">MTRCLPENILLTLTVCGVISGITLGVCLRDPRVIWTKRQLSYLRSSLSSLDPSTAGRMGSIALIYYFTTTMIAITIGIILVVSIKPGKWMITDIEELVGTSNTIPCVSSAVDTMLDLVKGMFPENLMEATFRSEKICLKFMNGSIHVNSFEATKLTEEERNKYQATPEIVRTDGMNILGLVVFAVSVGIVLARIGEEGAPLKAFFKSFETVCMRLISFVIWLSPVGITFLIAAQIVGMKNPGMEVQRLMGYMICVLVGLSIHGLIVLPTLMIVIARRNPIKYVYGMAQALLTALATSSSSATLPLSIKCVEENNGVDPRVARFVLPLGATMYFVHFLKNYSLILLNESILAEYIAALQNRNMDGTALYEAVAAIYISQCVGQDLSIGSIIIVSLTATLASIGIVTMIMVLIAIGLPSNLFVLIFPVDFFLDRIRTTVNVYGDSIGAAVVGKICEKYLPNRDGEIASTGYHMLSQTATDPVKRRNFCENHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDV6</accession>
    <name>A0A0N4UDV6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9273</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDV6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDV6"/>
    <dbReference type="WBParaSite" id="DME_0000553201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000553201-mRNA-1"/>
        <property type="gene ID" value="DME_0000553201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000289">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="627"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="691"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000553201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="753" mass="85385" checksum="73BD742B026D35CA" modified="2016-06-08" version="2">MPGVHPTRYRQQFLMENASNGYPTSSRHPSISGSYYYSRGGATTGNSSISSSMPSPAIASNARFPPPAKYNGIVDNSIHQGPRQGAAIIEHETPSYWVEHLATFAVGREFGLLNPSDGIRKLKQLEKNSAIWAQPMVLRLRPNLISVEDENGDLVEQFPMDLVADPNAHLSTDPRDVYNNLLLFIVKEDKRRGRSITPTEMHIFQCNRVSAGEVVEDIKAFLTGHFQHVIKGRRDTGFFIGPSYVAPQFGPPPRGYRDDASASSDNSEYFERDVNTLNRCFDDIERFVARIQSAAIAQKELEAQAYRYRTAQRKRGNRAPPPDAQSGILQMRAQLPSELEFVDILQKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLTIILDSCHWGLGRNIAPQVVSPLLSRDARELMQNCLTSKESDVWMALGQAWRVPPEDWIGPLPAPYRPVFLDGFAPYGAPDSYDTNLPYPHARFLNQPQPIHRGISAPPPQTQSGYHSRAPIRDRSVDNLNIDLDRMTLEKERLDFEREKIAERERRLIADERRIQQEKQRLAAEREIMAQEAEQRSMGSSYALRNEETRSHQQSPVVSRSTQQYTHTNGEQTSSFIGPIPQPDPSPRQKAFLDDIVARRGKLVQVTYDRIAQNPKELTVSRGEYLEVLNDNKNWWECRNVHHRTGYVPHTILSVINLERNLSPHSLPPQDPSFSDRIGATSSSQQNPPSNHPGPSLSPRPGMMSDDTPDYIKKRQGKRGEFRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEC2</accession>
    <name>A0A0N4UEC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clathrin_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEC2"/>
    <dbReference type="WBParaSite" id="DME_0000572001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000572001-mRNA-1"/>
        <property type="gene ID" value="DME_0000572001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000572001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35358" checksum="96735D99AE6DB776" modified="2015-12-09" version="1">MECTSHVEENGDRLSALTIAEESITSYEDGRRQIAESTKLLKRWKKNEQEALWDNIDEDMHSFTLDLSAVEANNCDTSDNMSNRHFMDDIAATSNEPLLIASILKILYFHFNMLKANGETIPSSRGPFVLPPTSPHKSNSKRISSHLIRSPRHLSSISPFSPRTDMVADNDFFPSAYCSDSLPISTQSKSEVSPNNSFDSEYFSMDRQSNEELRFMKKIFTEYIANSSDNELSGGESVAYDGSSTSSSLNDLDETQNSMNSTFEHDDLDAHIIGFAEEYGSTTIGLKASTSFEYNGEQALDKPSLTTIPRQKIFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEC7</accession>
    <name>A0A0N4UEC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9318</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEC7"/>
    <dbReference type="STRING" id="318479.A0A0N4UEC7"/>
    <dbReference type="WBParaSite" id="DME_0000572501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000572501-mRNA-1"/>
        <property type="gene ID" value="DME_0000572501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000572501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="46" mass="5252" checksum="C25835A7EAE27063" modified="2015-12-09" version="1">MVMRDPVSKRARGFGFITFADPSSVDKVLSHEQHELDGKRVIFTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEL2</accession>
    <name>A0A0N4UEL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bm7255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS816</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEL2"/>
    <dbReference type="STRING" id="318479.A0A0N4UEL2"/>
    <dbReference type="WBParaSite" id="DME_0000582201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000582201-mRNA-1"/>
        <property type="gene ID" value="DME_0000582201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12510">
        <property type="entry name" value="RRM1_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="872"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000582201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="952" mass="105125" checksum="82D2D691D30E85B3" modified="2015-12-09" version="1">MSWIIRLQHLPLSANASDIRAFFSGLRIPDGSVHIVGGPDGDAFIGFATDEDARQAMKFDNRRIHDQRVKLLLSSRVEMDAVIAKARSGDLNLANVPVTSSAITQPLRHEIIRAVNGTSEQQQHQTNVTSQVIPTSTSAISTLYALRNTPNINQNNSYQQEFIRGVDNGETWNRNENASDSWKNTNTSNYDGKQQQQQRVVLPWQDPKMLNVIGQTTTAPIYHQTRDERYNQYESESFQGYTASLQPSSNSAVYQQHIQGYQGTGIVGSVLSGQSLQIPPTLSSISPSTVAGTNARLQNSGSVLPSANPFAVYPHNVPIFPPVASVSLKHENRYVELSRLPSELLRPAALEQFLQPAVPLTLSSVKVIFDPKGFPLHSLVRFENVKDAENILNRDGEQGIRIRPSSKEIFDAAVDGSLQIPAYYLQNKNGQRVYDRNREDRGRERLIGPSSRRHHSPERRDVDPRRDERPIVGIRDREHRLPRRGRSRTPPSLTRDLRDTKRRREDTARFCIEFTNLPFRVSEAEIREFFGVRCQPVKVSRAYNADGQASDRWILEFGDMDTAERAYRTRGKIQDRLIRARRLTNEEADNLLSVPDKFGLQKKEEYERKFGQAENVIGDTSSSHLDGMTVPLMNGNFETDNPSGMGRTVNGPLFNGPTILPGAAATKGVSQEGNGLSAGSSTASPLIPGNPAIAHPMTYRHQRSNGPLIQGGPPRPPLIRPPTFFGATPSSTIRQRGPPPTRGSRGSLSHRVVHSGHVDNASSSKQTYVALENVPESCSDQDIVAFLDIKPSKMSKSATIQHALNGTVFVDLGNVDDALKAVSKNQQKIGENVITVTAVNHQQMQKKMESNTDLQQKMLEPDLIASVGEPGTVISCDGFPPNVTLADVSQFFNQFSLVESSVKIKLDDRGMPTGECLLSLGSVEEARKAASMLNGRKLNGSAVTLTLVQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UET1</accession>
    <name>A0A0N4UET1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS844</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UET1"/>
    <dbReference type="STRING" id="318479.A0A0N4UET1"/>
    <dbReference type="WBParaSite" id="DME_0000590501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000590501-mRNA-1"/>
        <property type="gene ID" value="DME_0000590501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="181"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000590501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63139" checksum="92EDA7410DF7A678" modified="2015-12-09" version="1">MSGRPLVRKSDIGAPPARLSGGAPPSLSAALARRGMRGGFKGGIVGKNCGTMNRKRRAGDILEESDSESSSAAEENDNNESEEEIKKEKEEIVEGKMRKPRKKRRFRFTDSVAKAKRKAERRAQLEAERKENDELEKQQEGKKEEEDKNKSPTPPPLPKAPMIRSYSPMQLLCDNLLRKLQAKDPEEYFAFPVTPSIAPDYHEIIKEPMDFSTIRMKIEANEYQDLASLHNDAKLIVKNALSYNERNTIYHIAAQKLETIVNFYFSEQNLRYLYHTLPFCKDIPLEKVGLTPKVRPPILPKVQRNFVIDNMTTSSILDSTDPSIRRKLATRVPDLSVLPNCESGREPKAHLAFLDNKDGAVCLNIVNSVTSERTSVTLGDLIGKLDEGTPGLCTPADHKIPPQMPISFLSYGPFSSFAPQFDSTWANLCERDSRLLLSTYADKENAANAISLRHMVEDAGEHMIKIVDDLLDTLTDGEHSKTISALEKKEQMKMPDLDDDVNMDKLLDSIESLENLGIDVSFVPEVRKIYGSKAVSKTSQVCISKKRIEPLGEMNFSLKFSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEU8</accession>
    <name>A0A0N4UEU8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS862</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEU8"/>
    <dbReference type="WBParaSite" id="DME_0000592301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000592301-mRNA-1"/>
        <property type="gene ID" value="DME_0000592301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000592301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7705" checksum="ADBE38E89B2CCDE4" modified="2015-12-09" version="1">MRGGQGGIKKGVTSIKQWSVMIGSVLLSGLNPSLGGYVWHLPLSLSTVVAKGCFCSSRWNLLRAKGACGWGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF81</accession>
    <name>A0A0N4UF81_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRP7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1019</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF81"/>
    <dbReference type="STRING" id="318479.A0A0N4UF81"/>
    <dbReference type="WBParaSite" id="DME_0000608001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000608001-mRNA-1"/>
        <property type="gene ID" value="DME_0000608001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000608001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27289" checksum="C9B3F2247A1AC86F" modified="2015-12-09" version="1">MSWQLVCVEEFVLLILESYGKKVLVYRINREKYTAERNLFLKSDATDPFSILVVNLPSHFTKESLQTVFEKILCCRVKNIAIRSIAPNKSVTEGYHAMSVTLQTEYDVMDVLRRCQSISPFYLSDYGIRPSNCGLSKWCEDYRNEYIPTEELQRREKKWAKKMKNVPDADGWITVMRSHHKTVPNAIIAKNKEDISRLSKKKKSIVGTEELRKKFEMDKKKLALAKAARKFRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGK8</accession>
    <name>A0A0N4UGK8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS1277</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGK8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGK8"/>
    <dbReference type="WBParaSite" id="DME_0000663301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000663301-mRNA-1"/>
        <property type="gene ID" value="DME_0000663301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="215"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN51304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000663301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33142" checksum="D88BAAFAC7947736" modified="2015-12-09" version="1">MNADIIVFGSIAHDLISYTEKLPRPGETITGISFEASPGGKGANQAIQAARLGAKIGDDIFGEFCVKNLEQSGIMVDFIEKSTTARTATATIIVSTSENMIVITLGANLEMKADRAVQLYQLIASAKIILCQNEIDNNATKMALEIAKKNNVKTFLNFAPCTPTFDKDMLKNVDILCVNEIEAESLSGRQVMNTDDALMEAESFLNLGPSMAIITLGAQGAIIAHRDDKKIIRKFHVEAFQVNANDTTGAGDSFCGALAYFFVKMPHLSLEEQLRRTTLVASISVQRKGTQKSYPWASEIPEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGT0</accession>
    <name>A0A0N4UGT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9741</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGT0"/>
    <dbReference type="WBParaSite" id="DME_0000671501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000671501-mRNA-1"/>
        <property type="gene ID" value="DME_0000671501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876342at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000671501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15331" checksum="EB82C08E4843BABE" modified="2015-12-09" version="1">MVDQLKIPNVQKLLGQFKGKAKMVVSHNAVTDENYLTALNTLKNQYGQRENRYHLLLSRLNVTTVNAIAKNEDIEQFWCLERVGIEAPSDMTSDNHALKRFSESVEALEDGRYEVELPWKTNQPKLPNNLGEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHB8</accession>
    <name>A0A0N4UHB8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9768</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHB8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHB8"/>
    <dbReference type="WBParaSite" id="DME_0000693601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000693601-mRNA-1"/>
        <property type="gene ID" value="DME_0000693601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="115"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000693601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42779" checksum="9619BEBC3F740BD9" modified="2015-12-09" version="1">MKRILGRKVPEGELCAVCSDLATGYHYGVASCNGCKTFFRRTIVSEHTFVCQYQGNCDVNKNIRCACRYCRFNKCVAVGMDAKAIQNDRDRIGPTKKIKLMNQNSEDSSVQIRSFEEKLISDIQAVEKLCLRLRQCILPEITSLKDAIFGPSLLYDMNNLETDPTTVTKNLYMATMKDVQVWNKKEIRVCLEWAKTFDFFNQLNQEDRIALIKNFGFTFNLLNRNFYAPDHGNDKLVLPNGAYICRQAQNEVKIPGCRTIYHRQMDEIMIPFRVMQVTVTEFALFKANAINLSPGTKQQVYQERAKYLTALFYLITSKCGIPAGAQKYGSLLMMASSVQNIIALNEENMQVMDFFEENWKLDSFVKEICLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHJ4</accession>
    <name>A0A0N4UHJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1579</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHJ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UHJ4"/>
    <dbReference type="WBParaSite" id="DME_0000702701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000702701-mRNA-1"/>
        <property type="gene ID" value="DME_0000702701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6355676at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="334"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000702701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="63099" checksum="D67269EE82B68015" modified="2015-12-09" version="1">MLTLSRNILLLWIYPKNETYPLVCGDRAIGYNFSVITCESCKAFFRRNASKQEFVCQFANNCSINAISRRFCQFCRLKKCFQVGMKKEWVHKEKNRCAKKRKLNLMILEKVEDVDKVLSEMGDGDIVLPKHVLADLVQKSHVTRNMKYCRCKCSCGFYPPDTQLTALYSKMFSEENISNLDIGNERNDSINNAMQQIRFYVLLYLDQNTVFDNTKSKFAEMVLLNQNLSKKWFLKFYNIHIGLMIRFQSGATNIDRSLLSENLSNSTEAWKVANKPPVIQSNLSNPCYSSWPCSDSSINSGISSNFLTEWPTNNHGIALDTTHLQTIFIEDELIVGKAIQELIAANNILKQPLDLTVKQKAEDDFNLMDIVRMTDLALRRIIFMAKELSLFRKLRNDDQIALIKGSCSELLILRGVMVFDLRKHAWNPHAKLNWIFLITFDEKWRRNENVMLLLNAITLFCPDRKNLNEANQIADKQQQYRTLFRKYLALLCPSFEAEQAYNGLLQKLVELHHLNESFLRVYHKLNINEVDPLLSELFDLSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHT2</accession>
    <name>A0A0N4UHT2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GINS complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9858</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHT2"/>
    <dbReference type="STRING" id="318479.A0A0N4UHT2"/>
    <dbReference type="WBParaSite" id="DME_0000712801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000712801-mRNA-1"/>
        <property type="gene ID" value="DME_0000712801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000712801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13813" checksum="AC12AE1B94325F8B" modified="2015-12-09" version="1">MDPNLCQFVAENELIQIIPNFNYEKLYLICGDVGPFEAGIPLEVPLWMAIRLKKQHKCRILAPEWFNVESLRKFIDAETREKGGLTPVPRYFREFSNLLLLDAKDDIIDADQVAFAPIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI15</accession>
    <name>A0A0N4UI15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DAN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9895</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI15"/>
    <dbReference type="STRING" id="318479.A0A0N4UI15"/>
    <dbReference type="WBParaSite" id="DME_0000722701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000722701-mRNA-1"/>
        <property type="gene ID" value="DME_0000722701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DAN" evidence="5">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000722701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18360" checksum="B4A46E32C16680CA" modified="2015-12-09" version="1">MKYMVDNSSFFEHLSRKAFMSLQPEPYLDSSLLSSDQRKVKWLQRKFKKQQKLERRGKKIPSSPREALQQVNQNMLNLGPGEMRRASQCEGQLFKQRIRMDGCLSKVVINRFCHGTCMSYYIPRLKPRRLKLKAMFQSCSACQPSEYDTVEVRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIZ7</accession>
    <name>A0A0N4UIZ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1869</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000035">
        <property type="protein sequence ID" value="VDN51896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIZ7"/>
    <dbReference type="WBParaSite" id="DME_0000760201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000760201-mRNA-1"/>
        <property type="gene ID" value="DME_0000760201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5773018at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF11">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000760201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35470" checksum="F1D8B554ABFEC26C" modified="2015-12-09" version="1">LFTLYFPVKSQIKPRGPLTKDFIEWLIANGYESQNFDRPDIGPSGSFGGRQRRNERIYHEPVIFIHGNADAALHIQSPIATGWSRSIQYFLEQNYSTAELYATTWGDTWAGGSVLSTYSTMHTCSNLLYLRKFVRAVLDYTQAPKIDVIAHSLAVPLMRKVLKGGTLVATDGNCNLGAPLGHRIDTFLGIAGANYGLCICQFAQTIPAFCNSLDGLYPGYTCEDQLVCAYPDGECEQKNYSAFLESLNNDATREADHIYAMWSDVDEVLLFRGMTWGKPTSRIPGMNGRWVSDRNGHIAMKDFTELRQYEAVAHHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ05</accession>
    <name>A0A0N4UJ05_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1878</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000035">
        <property type="protein sequence ID" value="VDN51905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ05"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ05"/>
    <dbReference type="WBParaSite" id="DME_0000761101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000761101-mRNA-1"/>
        <property type="gene ID" value="DME_0000761101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000761101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22097" checksum="6780744FC861E4B1" modified="2015-12-09" version="1">MIEKNDRSDDWEGVSILCQALDTAFKYESESLVAGKSILEMGFCTGLPSVFSLTNRAAHVTLFSMEEIIMNDCVKPTLARNKVKPTQKRLIFGEFSDLRKSTDQNRFDIILASEYLNTDKFSYEELHDIIDYLLTPDGLCIFSSRMSYFHHEGKFIDLIKVKGKFDVFERWSSPKSDFVQRKVIQLTRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJS8</accession>
    <name>A0A0N4UJS8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2056</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJS8"/>
    <dbReference type="WBParaSite" id="DME_0000793101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000793101-mRNA-1"/>
        <property type="gene ID" value="DME_0000793101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000793101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11238" checksum="C97E91EC8447CFCF" modified="2015-12-09" version="1">MKLCECIPPPPNIELLSPPPDPSLIWHFISNEPIDNLEKINECDGNKLSINSSVPYVPNNQIFDYFPYLFTAIVGIFVIFIVIVVIIIINILRIRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK66</accession>
    <name>A0A0N4UK66_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2219</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK66"/>
    <dbReference type="WBParaSite" id="DME_0000809401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000809401-mRNA-1"/>
        <property type="gene ID" value="DME_0000809401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000809401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13575" checksum="FB282146017FF303" modified="2015-12-09" version="1">MKKRNGILFCYLMAIQPHRHVPKFPRRHERNRLDCRTHERFVRCGPEPHCEMSCENLFSPPHCHTIENHPKCYYPRCICKNGFVRNKEGFCIREWRCPNRFTSLLLKFVNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKK5</accession>
    <name>A0A0N4UKK5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2306</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKK5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKK5"/>
    <dbReference type="WBParaSite" id="DME_0000827601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000827601-mRNA-1"/>
        <property type="gene ID" value="DME_0000827601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266921at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000827601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36976" checksum="02843F071D7B7D5A" modified="2015-12-09" version="1">MSATEQMAQLLNELMGPKRNADFGDANEPDFDEPDVCKHFLVSFCPNEMFRNTKADLGPCPKIHDPSLRLKYRASSRFEKLGYEEEFLNKIRRLDDEVKRKIEKNERRLAVTQPIPNRTFFFEFFIKFFTAISLSNRLNFTFKAETLGALGKVDEAKEAVRQADKFKQERAALDRLLTQSTNPSNHIENLANQLSKPMEVCQVCGCFMLVNDVQQRIDDHYAGKQHMAYAKIRATIEEMDRKREEKRKVIQKLFFFLSGPFLVSRTGERLERENRHEKDRREKKEKEDRGLRDERDERDKKDRDRRKDDRDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKY4</accession>
    <name>A0A0N4UKY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Angiomotin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10369</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKY4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKY4"/>
    <dbReference type="WBParaSite" id="DME_0000842501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000842501-mRNA-1"/>
        <property type="gene ID" value="DME_0000842501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5974715at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051747">
        <property type="entry name" value="Angiomotin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826">
        <property type="entry name" value="ANGIOMOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826:SF14">
        <property type="entry name" value="ANGIOMOTIN_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000842501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="722" mass="83315" checksum="D5CD7DBBB2AA6363" modified="2015-12-09" version="1">MQRTSDELVIDESKPIYRNNEIIRLKEIGDEQIAATRSVWLSEKSSDCCVEKSSYGDNDDNDDNDDDDNVDNDDNINVPTKRLTNNCSTTKERRIHAVSPMQYQNGRFLNYGVDQEADAKLQQMINNYQAQVLQQQRSTFTDHEIIRSFPEPPSLSASSVQQKMPPMSHSQPCLINITERKKDKVGESAPPMYTSLEQSDIRENLSLKSKLLSTQKCLKALQDENASLKQQCEFHKKKTNRLQQLESAYEAIEKEYESLTMQNERQDNLEKAMRAKMENQISRLSTENDILRERVDELTQRLQVDPQSDQLNKLNLILNEMIPQNKELLACKERQKRDIQALEITLKEQRNHIQILEKALSNAQEKVWKKEKEVEELSGNTERILSLQRAVEKSLMDKQKREEEWSRERAQLEMENAQLKMQLAKESMSVGVKKGAGARSPDNEEVVAKLKKTLHTKEDKITSLEKNIIELEAKFHEEMQRNKMAISTQSDSLSGKLKKMEEEKSEKDRKIAELTEEKEKLIEKLEDERKNSDNRISCMEREIERIRNERRLREDMARMEQMRLKIADRRCFTTDRTRNRFNSHDRTSSGSKASICQNHARANSASALLRSDLQFPIVNASSSLNESPLDLSSSSSLSKSTLPQNALCNNDSNKSDSIPDGLCDGSRCSRQTPIRSHYDIDFSDSEGIFSRFTRYTGHVAAHRNGKRTKENALKSQEEVWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL44</accession>
    <name>A0A0N4UL44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ran gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2474</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL44"/>
    <dbReference type="STRING" id="318479.A0A0N4UL44"/>
    <dbReference type="WBParaSite" id="DME_0000849901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000849901-mRNA-1"/>
        <property type="gene ID" value="DME_0000849901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000849901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47748" checksum="E338B28199451616" modified="2015-12-09" version="1">MCKFQRALWSDIFTGRLTKEIPCVVKSLCDAMMISGTCLVELDLSHNAFGPICADSLREFLESAYSLEILKLENNGLGTGGVTVANALLKCCENAERNGTKFGLKTLIAGRNRLEQAGAVAFASFFSRVCTLEEINLYQNGINAIGIKQLVSSFGANHQLKIINLSDNTFTAVAAEAIALVLPQLPLIEELNFSDCLCRNKGASAIITSLNPNIHQSLKMINLSGNEMSPSVVEAALKKLSNGFHLQSCILHTNNLGSSFNTMKQYWISRDFVDLGNESDDQGSLEDGDREFHSDDSSDEEQFALNKSDFVEADSKTLLSDKEMTVSFRDQQNQWNTVDDVLDVTSALSAEKPVHIFELKGNSLGIVAGECIANSLRFHQELKKALWSDLFTGRKKQEIPPVLVKFFYFIYQYILFIYKKSGEALCRMLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM94</accession>
    <name>A0A0N4UM94_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2787</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM94"/>
    <dbReference type="STRING" id="318479.A0A0N4UM94"/>
    <dbReference type="WBParaSite" id="DME_0000895801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000895801-mRNA-1"/>
        <property type="gene ID" value="DME_0000895801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000895801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33201" checksum="7511E17EB0D71AF9" modified="2015-12-09" version="1">MSQFSLADILAAKKRIAGTIHRTPVLTSSTINHLCNKEVYFKCEHLQKTGSFKSRGALNAHFRSGNFGQALAWAAQLFSIDCTVVAPDNAPYSKIDAMEGYGAEIVKCPAHERDALSKKLQKENNWELIEPFDDYRVMAGQGTVGVELVEQVPDLDAILVPVGGGGLCSGISTAIATLKPNIKVFCVEPEGKELEKSFIAKTRLWDVNAFPVDTIADGVRVIAVGERNFPQLLSYCEHSVLTVNDNDITNAMKLIYSRLKQAVEPTGAMCFAALLKYPILLSSYKKVGLILSGGNFDWKILQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMG9</accession>
    <name>A0A0N4UMG9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WS_DGAT_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2832</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000083">
        <property type="protein sequence ID" value="VDN52859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMG9"/>
    <dbReference type="WBParaSite" id="DME_0000904201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000904201-mRNA-1"/>
        <property type="gene ID" value="DME_0000904201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000904201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15868" checksum="96C52E763350232F" modified="2015-12-09" version="1">MHPTCVFLNNQGTSEIGFVEGIVNTVGNFLLGSKFNIDRLEAFCEIKDALYKIDHPRGKTSQNRRSFDSGTISENDGDGKEYKGYSPSVGIPVYTKYRRNLYVINVRSLFSVFIVSVFEVRLGDILISDFIFILLSYLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN28</accession>
    <name>A0A0N4UN28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat-containing protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3013</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000096">
        <property type="protein sequence ID" value="VDN53040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN28"/>
    <dbReference type="STRING" id="318479.A0A0N4UN28"/>
    <dbReference type="WBParaSite" id="DME_0000929101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000929101-mRNA-1"/>
        <property type="gene ID" value="DME_0000929101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="4">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="3">
        <location>
            <begin position="346"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000929101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="77397" checksum="5B422D4E8A272C2A" modified="2015-12-09" version="1">MKPIFRIGNDVLGEGAVNFEWRPGGKYIAVCGSNRLVNIYDRSGKLIDAITKAKDVISMCWDKDGDLIALASDQSPVVSFETSVFLLWSHVSSTLAIGTNKGNLVLYNHRASKKTPIVGKHQRMITCGAFSDGDFLALGSKDAFITVSSMNGDSLYSFACNSEPTLIKFHSMKRANEKKKTKVDIMLSAVLEDRMIMLINLDDSENPINLQFQNRYGKIVSYVWFADGYILLGFIKGFVVCISAYASEMGQEIFSVQDFKSYLAYLCINENSEKALIIGDNQLKIRELNQLEEINGLYNIEEESKELYKIGTTEDGQFVAISSTSGTLQVFLAKIPILGAVYNEFMAILSSLNEITIIREGEKVATINIELEPTVIGVGPLNVAIAMNNRAWFYEMNEGSQNLDSAVVYEFEYISTINAMKMNYEFAVAKLDGRAQLHKMKGKDNRYGSDEDTLLFPDSDHSNFRLQDVALTANFLIYCTDGGHLQYFALEDSTCVNEYRHVSGIKTIFPEPGGIRLCFFDETFDAYIYNPVDDGLVKVPIGSTAHFASCLWENFTIDKDTFVIWDSTNLLAFSFLKDQIDGKFFFCIVISIGVNEYRHMSGIKTEPGGQSLLQLGKTAIPHQYKPLMLCKGIMYCQTQSGQIGSILLESHKTQIAVDDKSFAEIENLLQQTLNLKRYFCHWNLKFGIGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNA3</accession>
    <name>A0A0N4UNA3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3087</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000103">
        <property type="protein sequence ID" value="VDN53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNA3"/>
    <dbReference type="WBParaSite" id="DME_0000937601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000937601-mRNA-1"/>
        <property type="gene ID" value="DME_0000937601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000937601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14709" checksum="6B5A26C17D6A149D" modified="2015-12-09" version="1">MFIRSPRVPLWSNYEGQWNSSSNTLVSKHPHIQVILSQLLTRCEWRAASQRQHDEERGCRVVLSSRVYSGSVAPAAETVGAACGSCGGARVGDCHQGVSGDLSLERSISRGLGAARRSARYSHRRLSSRNFHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNE7</accession>
    <name>A0A0N4UNE7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3131</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000107">
        <property type="protein sequence ID" value="VDN53158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNE7"/>
    <dbReference type="STRING" id="318479.A0A0N4UNE7"/>
    <dbReference type="WBParaSite" id="DME_0000942701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000942701-mRNA-1"/>
        <property type="gene ID" value="DME_0000942701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004690">
        <property type="term" value="F:cyclic nucleotide-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF91">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000942701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41650" checksum="95F2AC895EC1AE27" modified="2015-12-09" version="1">MVGGQTDPRFSTGLRFFLSVGLAEMNNEDEFREMKLREFLKIETIGEGAFGKVYLVKSDRNRKTYALKAINKRLILNKKQQAHVISERNIQMSCDCNFIVRLHRTYRDNRSIYLLMEYCIGGELWKLIKERGRFDELTTRYYCAAALEALQYLHNRSIVYRDLKPENMLLQLNGTPKLTDFGFSKILGGNGGKTWTFCGTTEYLAPEVILNKGHDTAVDIWALGIFLYELLTGMFLKFVRHINSVDLLNKIIFRPPFTSSSSEKIYRTILIGFDQLLWPKYISNDVISLIRNLCCHNFEQRLGYRNIDEIRSHRWFSTFNFESFRNSSMTPPIVPTVYIFYNCFYKLFSQKFLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNI6</accession>
    <name>A0A0N4UNI6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3168</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000110">
        <property type="protein sequence ID" value="VDN53195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNI6"/>
    <dbReference type="WBParaSite" id="DME_0000946801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000946801-mRNA-1"/>
        <property type="gene ID" value="DME_0000946801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000946801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10046" checksum="1A7F1586E4587857" modified="2015-12-09" version="1">MVRDTNGVSLKIIEDHPLRKNSLRPNLTTICYLEVISGNHRLNPDKDSLRTGTLQMLPIVFHITSSTNVLSGMAKGNNTRYIAEKQFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNV0</accession>
    <name>A0A0N4UNV0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3274</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000118">
        <property type="protein sequence ID" value="VDN53301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNV0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNV0"/>
    <dbReference type="WBParaSite" id="DME_0000960701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000960701-mRNA-1"/>
        <property type="gene ID" value="DME_0000960701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035498">
        <property type="term" value="P:carnosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000960701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32412" checksum="ADD2BEC066BC81CE" modified="2015-12-09" version="1">MIATAGFSMFDQDTMRYIVSEFLMTKVKAILHQIVREWSQQGAKERNISFDLVKSALRTKFSDVSKRASVRILIPGAGLARLGWDLVHEGFSVVCYEFSYQMLLVSNFMLNHTFQQKLKVYPYLFDTSNTWDYDDRTRAIEFPDVHPGSLNKELNTFEMNAGEFVETTQSNNDVFPVVITIFFLDTSKNVFEYVDVIYRILQSGGIWMNYGPLTYHFASSTCLDAAEVPYGMLMKYIVSKGFRFVLNYNHFVIKISSYVINDLSMLRQSYDCAYFQCTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPD5</accession>
    <name>A0A0N4UPD5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Poly(U)-binding-splicing factor PUF60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3427</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM half pint family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000133">
        <property type="protein sequence ID" value="VDN53454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPD5"/>
    <dbReference type="STRING" id="318479.A0A0N4UPD5"/>
    <dbReference type="WBParaSite" id="DME_0000981401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000981401-mRNA-1"/>
        <property type="gene ID" value="DME_0000981401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12370">
        <property type="entry name" value="RRM1_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12371">
        <property type="entry name" value="RRM2_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006532">
        <property type="entry name" value="PUF60-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034209">
        <property type="entry name" value="PUF60_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034211">
        <property type="entry name" value="PUF60_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01645">
        <property type="entry name" value="half-pint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="266"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="739"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000981401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="830" mass="89474" checksum="34D882F68E5690C8" modified="2015-12-09" version="1">MVIVPEFQALNNAFLENVIRVVLWSMSSGEADTETSPLGGANGTIERTVPTPPVSVAHVPSEVLVAMPVLPQAGNIIVGPGAKKEAQLLGLGLIKLRSKQKDWLADAKKYAKEQSIKQVLLRQTVAHQQNQQKVAMYAQALSLMARVYIGSISFEVREEMIKNSFGVFGPIKSINMSWDAVTGHHKGFAFLEYEIPEAALLAQESMNGVLMGGRNLKVNVLVSFNINGSLIALSSGRNLQSEMRPSNMPQAQPIIEMVMQEAKAYHRVYVASVHPDLSESDLKSVFEAFGEVTKCQLARATGPNAGSGHRGFGYLEFNNAASATEAIAGMNMFDLGGQYLRVGKCITPPDALTYIVPTSAINLPTAAAVAAAEVTAKIQEQEMIAKKSPVSSPKVSFNEYLIVLILKNLIIFLQLIGGSLPSVSSSPNLASVTQSNVVTPVPPVGVATVPPLLSTSYISPSISPSLVSSPSHAYVSTSSLASIPPPPLPSTVPSTPVLLQSTNTSNSRRGFGGFATQSPPVQVVNIPPPQIIDAPLPPVSAIPTPPLPANSSTPLQIAQSTSSIISRINVDVVPKQKAAEPATFAPLPANIAPVNKKKYSRIIFIFSAVPPLSLKQPALTQGFDDSTDSMALVLLDSCIPRMDLEKANTKEKSKPDDRSYQNKKKKSKKLVPNLLKGPQLNTPQALEAASRAGELNDQMLSQAVNSDDVSLAAQEGLEIRGNDARHLLMHKLMRTNRSTVLVLKNMVTPKEIDDELEDEIRDECSKYGEVQEVVIAQDPSNESVKIFVRFADCREADVARQALDKRFFAGREISAQNYDQLLFDHNDYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPJ6</accession>
    <name>A0A0N4UPJ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10790</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001248">
        <property type="protein sequence ID" value="VDN60817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UPJ6"/>
    <dbReference type="WBParaSite" id="DME_0000988701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000988701-mRNA-1"/>
        <property type="gene ID" value="DME_0000988701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF6">
        <property type="entry name" value="PHOSPHOLIPID_GLYCEROL ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="226"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000988701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52811" checksum="7AE9AF713EE649AE" modified="2015-12-09" version="1">MIIVVTLLSTYFGAIFGISFATILLIIFGYGWGSLPFFYLRIIEAFQNFFSLDYPVDNEHERSIIIKRSSNFLNENDSDDEEFFSNENYKNAFDISIDAFKNGFETVIQDDLSAAFDVAPSFCETLLEYLNRLNLQKISNLLLCDLQFFAYAASLIFRYTILLPVRFSLIATSFLYAFCAVFLSYFIQLTLKQRIDISVTYCRLYGAGIGLIAKYHNSQNRPRSPGIAVSNHISPNDIQIIFADISSYGSDGFTVTGQKHGGIIWLIERLVERICPAIWMERSDSESRKRFTTEIFNSAISHPVLLFPEGYCTNNTSILRFRKAIFKSGINIYPIALRQKSRFGDSFWREDQFWRYMLRVITSWAIVYDVFYLEAMQKSHSETNETFANRVRQEISRAAQIKPIKSDGRLWYLEIERQRMKEMQMRKFSNIFYEIFIRREIHCESEIHKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPP7</accession>
    <name>A0A0N4UPP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3495</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000140">
        <property type="protein sequence ID" value="VDN53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPP7"/>
    <dbReference type="STRING" id="318479.A0A0N4UPP7"/>
    <dbReference type="WBParaSite" id="DME_0000994401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000994401-mRNA-1"/>
        <property type="gene ID" value="DME_0000994401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000026">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF127">
        <property type="entry name" value="PODOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="49"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000994401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30760" checksum="6BFA5F2963489EE9" modified="2015-12-09" version="1">MAKRLFTNLHANKSLSADTYDTGVGFCGWMIIAITWLIFLSTFPISVCFCIKIVQEYERAVIFRLGRLIGGGAKGPGIFFILPCIESYTKVDLRTVSFNVPPQEILTKDSVTVSVDAVVYYRICNATVSVANVENAHHSTRLLAQTTLRNMLGIKNLAEILSDRDAIAMSMQTLLDDATESWGIKVERVEIKDVRLPVQLQRAMAAEAEATREARAKVIAAEGEQKASRSLQEAAIIISESPAALQLRYLQTLSSVAAEKNSTVIFPLPVELIRHFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPX1</accession>
    <name>A0A0N4UPX1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3576</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000152">
        <property type="protein sequence ID" value="VDN53603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPX1"/>
    <dbReference type="STRING" id="318479.A0A0N4UPX1"/>
    <dbReference type="WBParaSite" id="DME_0001003201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001003201-mRNA-1"/>
        <property type="gene ID" value="DME_0001003201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001003201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44732" checksum="81621BF2EE679C5B" modified="2015-12-09" version="1">MKEKDQRSSLSYVDEKKDSSNSSTTTTRKDVYDDDSCFKAPLLLPHRKVNNRRRIVNNATINNINSNNNNRNGLLSVHEDIKNLVNETNQFISNDNIFAISDNNTNKTCLFSNIISISSTISDKDKVREEIEEEDEEEEEKGGEKKIDEKKEKKKSNIGNKDVFTDNIRSSGDNGNNGDNWRRYKCACSRMYLNSLLPCSSSLSSQCSSPLTAITTNVPLTANDIRIEAIRETVIDDFSLLLFRDIDHINVSYVELNLLKAKKESEERKKLYEENLRLGLAKKKGRKCKDENRKEERRSKKNKKDTLEMINERDTARTLIIPNSQSISVNPFLSHLSRKQLKLSVKAHSHFVIDFIPFKTKLSLDFRNSDLKRLNMEIVQTSGVLARFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ13</accession>
    <name>A0A0N4UQ13_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10838</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001255">
        <property type="protein sequence ID" value="VDN60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ13"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ13"/>
    <dbReference type="WBParaSite" id="DME_0001007701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001007701-mRNA-1"/>
        <property type="gene ID" value="DME_0001007701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="167"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001007701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32900" checksum="2885F572AE25EE07" modified="2015-12-09" version="1">MVKLDKFAIEFSNIEGAYFAGQEVSGKVIIENKEPKKVSEILLELKGRARTYWTKHSGQSRKHCSSAEPYFCEQFNTCYTHKFSRASLDIKEGRILPEGYHEIPFSYILPKNLPTSFEGEFGFIRYTCKATCERPWDFDIVCKKAFSVLQPAKISECNSFARFCCRNQGSILAEMHLERTGFTPGESFCLNIAVRNDSYKTLKACIKFVQTVNYKAKTFAGGEYVRSVDKVVIKKDISEINARKSFNWNERTIVIPSVPPALGTCKIISIYYSLQLQVKFSIFIYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQG9</accession>
    <name>A0A0N4UQG9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3754</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="UYYG01000180">
        <property type="protein sequence ID" value="VDN53781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQG9"/>
    <dbReference type="STRING" id="318479.A0A0N4UQG9"/>
    <dbReference type="WBParaSite" id="DME_0001025601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001025601-mRNA-1"/>
        <property type="gene ID" value="DME_0001025601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001025601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19616" checksum="46577B4AE8763A69" modified="2015-12-09" version="1">MCKLQYIFLMGVCGSGKSTAAEKLSKLIGAKFIDADYYHSPENKQKMANGISLTDDDRIPWLENLSQIIMNSKERLVIACSALKSSYRKILTKNLLNYFIFIHLNVERNELERRLESRKNHFVNTKLLSSQLNSLEIPIFETNCYIIDANKDIGRVLDEILQILLKYQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQQ6</accession>
    <name>A0A0N4UQQ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10888</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001266">
        <property type="protein sequence ID" value="VDN60915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQQ6"/>
    <dbReference type="WBParaSite" id="DME_0001035901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001035901-mRNA-1"/>
        <property type="gene ID" value="DME_0001035901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720547" evidence="2">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001035901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17438" checksum="4F3A176FAF848E51" modified="2015-12-09" version="1">MLLYFCFWIFLINGIKGGDNDITECNKAVGGFQRPTVEPGLCAHIDLPACAAIFPYQDAPGTILTHRNPGVSYKIPENCTHASLKDFAQRNCPSLCAFCCKAKQFNCANENRNATAAQSNCRDDDQQCSENRRYCTIEPYATVMRGKCRLTCGHCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR60</accession>
    <name>A0A0N4UR60_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3966</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000233">
        <property type="protein sequence ID" value="VDN53993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR60"/>
    <dbReference type="STRING" id="318479.A0A0N4UR60"/>
    <dbReference type="WBParaSite" id="DME_0001053201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001053201-mRNA-1"/>
        <property type="gene ID" value="DME_0001053201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001053201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15476" checksum="D19EA1BFCB5770C6" modified="2015-12-09" version="1">MSTECLQIENRFLRIWFVRHTRKFNLYGLVKTGVKDLLCVNNKMLVLITVALVLKNKQVKKGSRRTGTLAEKIRAGGAGFPAFHTPAGYGTLIHYGGSPLNKMAKSKWSALQKRSVYSTEEIISWKNYIIGSNSASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URK4</accession>
    <name>A0A0N4URK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4097</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000288">
        <property type="protein sequence ID" value="VDN54124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URK4"/>
    <dbReference type="STRING" id="318479.A0A0N4URK4"/>
    <dbReference type="WBParaSite" id="DME_0001068601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001068601-mRNA-1"/>
        <property type="gene ID" value="DME_0001068601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="177"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001068601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="677" mass="74795" checksum="4E6142340F53574A" modified="2015-12-09" version="1">MPISLGKRVYGLIRTTFSPAPTSTNELSDELKLNLNGENSSVPSSSNSFIKNEAEIYSGKTGLDLPVLLVEPFSRRVRSAYTGPDGGLIEVGGVRRQQLISMVNLDDELCLSFDGESLDDYDENVKIIHSRLYESTSGLLGSCSSLIGSINPENTLSTNADNYDWKSLDEDRCFGVSVSLYEKNPLTGINAGNPIADVFGVIARDNNAIIALADGVNWGEGARLAARCAIRGAIDHLNQHLFNSECRTTTEIFHALLGAFHSAHALILQEGGLLTTLCVGVTVQLRNSNTWVLCVCNVGDSLCFVYNPVYGVREVTVASHDICQMRDMRDAGGALGPVDGINPQLHNLTCSMTFVEPDDVVFITSDGISDNFDPVVGKFCVVKKEGDIEENCDLNKPVTISVKNSGAHQDAEFVRTRTCNASLPCVDAEQRHELMLMRMGDIISNGILPPSSRSRLPSINHVTNTAIVSTSQLCHNLIQFAMQLSMAKRRTLEDPELYRSEKHLSRSEQRNRRKMVRYKLSEMPGKLDHATVVAFKVGLWPDHSTAEIHLIDSTKPTYSAIINIISDNCLQELLAHIDSDNNTRNTRNRARSPYEETPIAYRVNQTKVPLKKHARGTIGRHTLSVDVAWLKKVVVSRNSSISEACRESSSLRFVQVVHPFFILEILDQIWIQNFSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URS2</accession>
    <name>A0A0N4URS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4157</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000341">
        <property type="protein sequence ID" value="VDN54184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URS2"/>
    <dbReference type="WBParaSite" id="DME_0001075401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001075401-mRNA-1"/>
        <property type="gene ID" value="DME_0001075401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5797004at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001075401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52783" checksum="200D521495F0A9C5" modified="2015-12-09" version="1">MAKNDELTYRLIYENNGKLIERNLLSKVNLQSTSDESQLLNQEQFIVVSDSDGFESQPDSRCASQTSGKSNEFDLDVHPNAYDLELQGKNLGEQVKFLKEQGWTFRLISERLNVPMTNCYTAIKKLRLPDEYWDKIKAEVRLKRRAKEAVENQLTAEIFANIPTILKKRLQTESSPNDESEKTESEAKRKCSSMSNEFMSLSGRKHLTLEDGKIVQYWRDQGLTLQKIAEKLKMPMSSCYRAMKRYQVSQKANLIMGNESNNSSADTTNSTANAITVSVAAASTTASNIETNYTISEGNHSCSKSISELLLGMVNATMKNDAINCTNELDQQTNGVTNRLSFPESTSAPKEDKARSNKSNKSSINTNLWKNRLAGNHCLFCGLELQSLSTDAISQHIALCRSNSSQASPVNLTTQPSITVPLDTYNVIITVKDKMDWAATKIADSNDLDEIIGLMKVEYNFLILTMIKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2H5</accession>
    <name>A0A158Q2H5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SKIP_SNW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4421</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2H5"/>
    <dbReference type="STRING" id="318479.A0A158Q2H5"/>
    <dbReference type="WBParaSite" id="DME_0000006101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000006101-mRNA-1"/>
        <property type="gene ID" value="DME_0000006101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="189"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000006101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62112" checksum="B52976DA5F38F677" modified="2016-06-08" version="1">MRYPNLQGRSHNNGIQQRIIRMVEGEKNPIAPHKCKRIDAFSVSTSVVIKEPPPYGSRNAWIPRKVEDFGDGGAFPEIHVAQFPLGMGMDLHRSSGAGKTLALQFDTEGKLRHDAIARIGHSKDKIIYSRLSDTKSKPLDEEDESFHKPGDEEIAERTEATRLALEKITSSKVASALPVRHAQKQGPVQYIRYTPSQQGGGHNSGVQQRIIRMVEEQKDPMEPPKFKINQKIPRAPPSPPAPVIHSPTRKTTVKEQNDWKIPPCISNWKNPKGFTVALDKRLAADGRGLQQVHINENFAKLAESLYLADRTAREAVETRAQMERRVAQNKKLEQEEKMRLMAQKARQDRLSVKKSHNDEMNQEAREREQIRRDRIDEHRRERNIARNNPDKLERLRRGKDRDISEKIALGLPDTRVKSTETQFDQRLFDQSKGLNSGGIDDETYNAYDKPWRAQDNIQQHIYRPSKNLDKDLYGDDLDRIISTNRFVPDKGFISAEPGAGRSAGPVQFEKDEEDIFGLGQLLLSAKETKKRGGDDVDDASSSKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3J3</accession>
    <name>A0A158Q3J3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS6885</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3J3"/>
    <dbReference type="STRING" id="318479.A0A158Q3J3"/>
    <dbReference type="WBParaSite" id="DME_0000252501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000252501-mRNA-1"/>
        <property type="gene ID" value="DME_0000252501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF276">
        <property type="entry name" value="DEGENERIN DEG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN56912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000252501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="711" mass="81477" checksum="37E567DAF7B9F5CB" modified="2016-06-08" version="1">MIKFFRMESLDPSRLQSVYINRRNKSSTPHIYSAVRRHKSLIEKIRIFAENTSAHGVRRVFVAQHAYAARLWLTGILFCFIILLIQAHHLFMKFNRYEKITNIELKFDQMEFPAITFCNLNPYKKSLVRLVPSVRDTMDVYENAKSFNKESDKRKESKVSKKQKLIETETEIKKLFEKFSEEVESYSQNYEDFDNNFKRFQRERYELVEAHCKCVGASSMECLRFQSFPVPEDAVCLCIYDRNSKTAWPCFNITYVFSFINIFCHFDHFSFLHSGKKITTREKIRKLWKPISTTTPTTTTTTTTTIPPTTTRHKNQSARVTAPETVKAMGFTGLTDGVAMLTRAKENLIFTMSALSKKQRIALSHQKNEFIEMCSFNGKQCDIDNDFKLHVDPEFGNCYTFNWNKSNIFMSSKAGSMYGIRVLLFVNTTDYMSTSESAGVRLAVHNPTEFPFPDTFGYSAPVGFASSFGLKKQVIKRLSAPYGECENNDELSSTKYIYGGYDYDPEGCHRSCFQNMLLNKCGCGDPRFPVLKGQKHCSAFNATARNCVETAIAEMGDFHHIIDNLGDCVCKQSCDHEVYSVTFSASRWPSGATDLGFCEEMSKEECEIFYGKNGAMVEVYYEQLNYELIRESEAYGVSFSVITIIECAVLFLDLLSACCNQVKKNGLANSLQSNRESRINRVNQAIININGSNQINEDCDEDQSNQKTFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3L0</accession>
    <name>A0A158Q3L0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6969</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3L0"/>
    <dbReference type="STRING" id="318479.A0A158Q3L0"/>
    <dbReference type="WBParaSite" id="DME_0000260901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000260901-mRNA-1"/>
        <property type="gene ID" value="DME_0000260901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000260901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="53073" checksum="C00FFFFD95EA8261" modified="2016-06-08" version="1">MKLKKVGLWVEGCGISPAPWVNGDWQAIMDLLSRLLADHLLQRKQSEGLEDITFKISFDAMMQMAEDVLGIPLFIVQEDLPSSLPNINLALLTCVVCIRNSIDIKPEKIKKIIPPKLVFEARCSRNTNVESVSKCIACNQHVFIVERVIIGKAIYHRKCFRCSYCKKLLHRGIFRFKNTLLECIEHWADNLLSNERQTYHQLNSSYVQIKPIPPPKPKNFSPRQDNLLSMNVNRDRTIKEENLQLTAILTKSHGDCNSNQINGKEITGIATSGPFLDSSETIPRLQHAENGSLQGDNYFNKPLSICSNVNCEIIPDDPSVLPVRPPRPKRESMLLQTAQCEINIVKNHVKNQDVSTKGSLINIADYPGFLNPFDSDEESVGSSDSYEENLNFDTQGDLDAYRIGTRLLSTSDRPKSTPPPPPKPPRLCADNKEKFFNTLPRPKKTFYAPLPPVPARRKVLLKVLHFFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Y0</accession>
    <name>A0A158Q3Y0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS307</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Y0"/>
    <dbReference type="STRING" id="318479.A0A158Q3Y0"/>
    <dbReference type="WBParaSite" id="DME_0000344101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000344101-mRNA-1"/>
        <property type="gene ID" value="DME_0000344101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF16">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000344101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33669" checksum="123CEE783DF27774" modified="2016-06-08" version="1">MDASQIPTLIWVQRKAEVECGEDTIDIVFLTESVFQGRVYVVGHSNEDQCVSRDTGRRTTSISIRKDQCGVVTTRSQSPAGLFVNVKVMISFHEEFITKVDRGYEISCFYMEADKTVTYPLTVSMRSLEPFTELAEMPRCRYEVVDPITMQPLNIVSVGDKLLHKWICDSTAPSLWCMTVHSCFVEDGSGTQFVILNDDGCAIDKYLLDNLEYGPGDLQAQKEAHAFKFADRVVVNFQCSIRLDIRDGECPHPQCRDLSTKKRALKRRALNDNMIINEGLVEVDVRAQQLDVLDPQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q421</accession>
    <name>A0A158Q421_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="4">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7826</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q421"/>
    <dbReference type="STRING" id="318479.A0A158Q421"/>
    <dbReference type="WBParaSite" id="DME_0000382101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000382101-mRNA-1"/>
        <property type="gene ID" value="DME_0000382101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000206">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049063">
        <property type="entry name" value="T6PP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041064">
        <property type="entry name" value="T6PP_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21141">
        <property type="entry name" value="T6PP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18572">
        <property type="entry name" value="T6PP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose-6-phosphate phosphatase helical bundle" evidence="8">
        <location>
            <begin position="684"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Trehalose-6-phosphate phosphatase C-terminal" evidence="9">
        <location>
            <begin position="824"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000382101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127073" checksum="494B9E54DE9CF750" modified="2016-06-08" version="1">MHHDAIFDYFITALGYHTVVFWRNAVPLIYDSDLSLGTRYRDSLLFSLALYDVNNSKNRLTELYAAVPGMVRSRVNSRLPSRIGSVENLTDISTIPDDEEAIVDGHAAGGLADTTHHKASQRVINVSNAPPVSLKRKDSGCWEIQQGSGGLVACVDPVMSVDKENVWLANIGIHWQNISDRKMDLETDSMPLSTNSLGLPLLKQAKAGEIFHVLSDDIKAPDLSETERSIEHDMSLISVLQNYNKDNYKLSPVFVDSSDYNTYYGGISNGLLWPSLHKLPEYICKDYDNPVILREHWCAYVRVNYLFAISAVRNGRPQDFVWIHDYHLMLTGQLMRSLDNSLEVGFFLHIPFQPPDDWMVKYRIVAEPILRAILRFTKVGFQTSRDRQKYVDLVKQYVARARVSYEQSIDVFTINHEGYTCSLGVFPVSIKNEDFLSIARCSDVQAKAEKIREEILSKGSPNGCFFFSVERFDYTKGIREKLEAWQRYFETYPERIGMDILYQIAVTNRRSVREYCIYQDICVELACKINQMFSSEKYPKWRPIRFERDGLPRAELIAHYLAMDVGVVTPIKDGMNLVAKEMLICNPRAALILSSGAGTEVQLGNAGFYDQERQCYFRIDDIGDVQTFADTFYKAATETREVREEHGLCLKHYLMNHDIDEWSAAFLDASWNCEVIRASKLNLLADFYQLMDKTCQVRRQIVERVLKGIPIRPQFGVSLENAKFSLEDSCKPGTHTLVLETSSAGEDSDGSNVHNTVKFDISNELEELEKDIAFLKFIESDEITNVEQFVATLGRFHPSGPEAFADEVEKTFDLLSTGDHFHYLFTDRDGTLKSYSCSYPASVQPAYSAVIQAQFARRCAQFCAIVTTAPLMHIGILNVSTIPEGYYAYGASAGREWYMNPAMQFKDDSVNEADLALLNSVFEKIEELLEDNTYRNFTWIGSGLQRHYGHITIARQDVNNSVSRHRSALLYQAVSRIVQDVDPTASTLTLREGEFDLKIFTKAKLSGRIFNKGHGIRLIQRKMGLKMNDGHILVCGDSETDLPMLEECLACSPKNVYTIWVTSNPKLQEKVRSACAARGNNHFIFVSCPEVSPEVLLGAMANATVREIRIRPRTENDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4E0</accession>
    <name>A0A158Q4E0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8530</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PLAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4E0"/>
    <dbReference type="STRING" id="318479.A0A158Q4E0"/>
    <dbReference type="WBParaSite" id="DME_0000464701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464701-mRNA-1"/>
        <property type="gene ID" value="DME_0000464701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="8">
        <location>
            <begin position="394"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="9">
        <location>
            <begin position="570"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="849" mass="94492" checksum="382BF926DF85FA94" modified="2016-06-08" version="1">MDLYHNFDANMLQLDEDDFKFSRSFKAHSSDVKSLVVSDLGLLVSGGRDSNVVITDRSDCKEIVKYATKDIQMVNAVAFYRSPTSGWVVFAGKRDGTIDLFASGNLCPVNTYSEHDLNVCKLHIDHLDCKMYSASWDNTAIIWSLENFKHSVRPSIIRLCGHTMSVWAVIPLPGTNICITGSADMTIKLWKGGNVTKTFTGHEDVVRDLIAISSTRFLSCSNDSTIRLWDISSEICLQKFQSHGGEFIYTMIKFSLKNDLFLVSGGEGGILEFWNVQADGEINHKQLLQTPVQSIWTIAFTPDGDINIGADDGNIYVFTRCSKRKANEEKQKQFDSGVAIRKEFLREQALARERNVVTIKVALDDGQPNMELKYTKGSDPVKAAEIFIQENSLPVSYLDEIVEYIKTNIPEARAFTEQQSHRPKPSERISLNGRQWDYVLDVTTDDGRQLKLPYNIDEDTNWAAQRFVFENNLPISFLSEVAALLETQVQSSLSSCKSSSFTDPLTGEGRYIPPAHSINSNGNIADPSTDKTSTLDPLTGTGAYTTGAACSSAFVPTSCLPIDRKRPRSILVPLKNFITFGFEQKSEKAIVKLREYNNTQSTYRLTDEQLHALEDLMSKSDCVFSDIHIAALTIGLLWDVDTILPILDVFRIAILNSDINKFFCLMKPEANSIRGRETLLKLMAYLVSATTDPVKILACRALANSAVHEWGRDMLTHDIINSVLTLISIIQNVKGSKNLQIAAISVIANLALILLQATESGLTELGPREDALRSIIQGIEKIEGYGHICETAQIRLLQAVVTLMWGDTTVIKLAKSRGLNVIVERIKDSIADESGKEISRDIIEMLHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4W3</accession>
    <name>A0A158Q4W3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9389</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4W3"/>
    <dbReference type="STRING" id="318479.A0A158Q4W3"/>
    <dbReference type="WBParaSite" id="DME_0000586501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000586501-mRNA-1"/>
        <property type="gene ID" value="DME_0000586501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000586501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120437" checksum="6403018DDABC8462" modified="2016-06-08" version="1">MASDRAAWRRLTFVALGASLTSESCLNEKQSSYVSRCHLLLYYLEKYRSWSVKVNGKNGILINDKLYKSNNESYDIPLNCIFRFPSTSQTLLFRSMEWPLSKECIQYVTNAPIHENIFEECSNIAGVNSSSTSDCVDSIGQSLPNISDMSNSSNGTINNELNNDDKSIQEEKPVYSPTKLSFQAMKNLSDKQASGSSKKLFWRMERNASDVSRKSLLHEPSENLSEVFCEQKGDGCLESITVDLKCSNANDCADNILQVEDSNQAISMKHSISEERNFAEKMKAQNVVSNELIIEDMDTKSIIRKEFCSKSMPSSSSSSSPPPSSSSLVAASKVFCHLPEALIKMEMLNSAINGCRKSETIYSVDLDSNDTRKEKIAANIGTDNKLLNIPRFVHSAPPSPKSALLYSFMFCLMRLISYPPDPRERRSSGVAMEALCQGISLLMRHIFGTYELGRKSAVPFRVRQSVKDGRSRLQLCHSPPEFRTLRDASKKLSGSVQFRRMKPYQIHARTSIGSTFIEEQHIDKKEQNPPGKDLNENFKILSSQEKPLGGESISSVAADTNNNEFTDAATSRLKSRTMIGIYENTQMEYLHKPEMKKKNQFHSLDRQITTMKPIGVHSCSSIAKDLKSVEADAVQTEISNGSLIKFIATNYSCPTRKTGIDESVKTNHFAIKKDNRLLELGSKKVIQQVKPINGRTAIKRAQDSINTSHGITTIQINVEEKSKANDESQTKKIRVFDMERPTVAFDSNLIHETTNESPSASSYALENSKTNAIDQNLINMTNQSQALVPAHASCHSHNEQLLRTKLMPYNESIFTTYSNNKGYGLRGLLENSKRHQALPNLKEFPSLVGIDSQRSALPYISLECPQVGAPQALSIGTDAAQSSFSASTVDSIYKNVVLQPNSTSFLSNHENIDKIGFTNLLKLSSLDTLNFTSSAATSLLNSSYFDLLEKLVAQQYQLQNLLQNPYQSLQQLHIQQELPVLPATVAATSNAFSPQNANSFVSPLIPASNLNLFVTREPTNFTNEIRNAPPLASDLLPYSLLNNAHQQMNDPRLINKAFYESLLAENLMRRDEIHPMDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4W9</accession>
    <name>A0A158Q4W9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Crossover junction endonuclease MUS81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS851</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4W9"/>
    <dbReference type="WBParaSite" id="DME_0000591201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000591201-mRNA-1"/>
        <property type="gene ID" value="DME_0000591201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000591201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41234" checksum="522E59457D2354E3" modified="2016-06-08" version="1">MGDNKNDKCFSNIDDDIIVEFAAVRSNVSSKIACIESKKDDVGGCQKANPPINSIVNYDGNSLKKRERKAEIGAGKERKEFQKTIEKFERDVRSTYNTKCEHNLFCIISEDLDNLINGFKKSVERFFEKRNIANQLLFEEHGQVIYWRRKTLEVIVENEKLTRFEYMTLEPFFVFFLGGEAFTNLIKSHSFDGYIQNQRNGISFFSPRITVIVYGIHQVEINKIQIHFFDSLDDISVFIGQMHRSIAKRIKRSEGKQQIIGTEKGTKEEEMIISDWWSKMLKHIHRIGDDHCRTLLKHFPNPFDFMKKLNQQNASDAIKMIENIKTDRGRKIGPMLARKIYLVLTSSDGSEIIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5F6</accession>
    <name>A0A158Q5F6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9892</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5F6"/>
    <dbReference type="WBParaSite" id="DME_0000722401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000722401-mRNA-1"/>
        <property type="gene ID" value="DME_0000722401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863975at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF171">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000722401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37775" checksum="84A994208FB58849" modified="2016-06-08" version="1">NRVTYCIRTIRFSSQISSNCRSPQKKTRHISTVLDYLSPQCYNEGCSVALVVQDTKFLVCKHQLSHASEYFRLLFLANNSHQNSLNEFAIVVSSFKHPPPSTQFKWFLECSIQAPIVKDIGDDTLETCMRLSKRFQAKGLEMACGRYIRENVNRKSPMVALCWLNWILKHKFDKATHDACLPCVATASLTCLEQHRNMITEKLLADLLAAKLRTLYSQTVNVFQTIHKMDHFFVDIDRCPRCGRQRDQGRVRVQVIPCRKMLGCERCLRDCGCEIIDQTRDYQAFYQCNHGLNPLNDQTNDCYCQIPLLASNISKIHVPHLSNGKLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5P4</accession>
    <name>A0A158Q5P4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2041</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5P4"/>
    <dbReference type="STRING" id="318479.A0A158Q5P4"/>
    <dbReference type="WBParaSite" id="DME_0000791601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000791601-mRNA-1"/>
        <property type="gene ID" value="DME_0000791601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000791601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49627" checksum="3DC1D0EB1F48DCFA" modified="2016-06-08" version="1">MFVDNREQEAATCESDVDKRITALQAAWNVTNAIQGMFIVGLPIAVKVGGWWTIAALVAVGYMCYSTGLLLIDCLYENNIKASITLVRQTYRDVAEAYRHGMGCFVLMAQLIELLSTCIIYIVIAADLLQSCVPAVGMKFDFEFLQACVLEVQFMCLDKPAWMMLVTTALLGCSFLESLRVVSHLSLANAVSHLIVNAIVIFYCISQISDWVWNEVPFTLDIRTMPTIIGVVVFGYTSHIFLPSLEASMQNPSEFKWMLKWSHIIAAIFKAIFGLFGFLTFGELTQKEISNSLPNQSFKIIVNTTLVIKALLSYPLPYFAAVRLISENFFRGTKHTLFTSCYGMGNTIREWALCLRILLLLFTLSTALSVPYLIELMGLIGNITGTMLSFIWPALFHLKIKAAKLSNQEKRFDYIIITAGLSIMIIGVYYSAIELAIAVKYGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6J0</accession>
    <name>A0A158Q6J0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3729</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000175">
        <property type="protein sequence ID" value="VDN53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6J0"/>
    <dbReference type="STRING" id="318479.A0A158Q6J0"/>
    <dbReference type="WBParaSite" id="DME_0001022401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001022401-mRNA-1"/>
        <property type="gene ID" value="DME_0001022401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000017">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="197"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001022401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54717" checksum="A89BF0B77ABC01B7" modified="2016-06-08" version="1">MSSSKGTTSVDNLDGITNLAEAALKIKDEANQLFNDQAYDLAIELYSKAIGLDGNVAVFYGNRSAAYLKKELYGSALEDAAKAIELDSDYIKGYYRRATAYMALGKFKNALKDYDAVRKARPADKDANKKFVECQKIVKRIAFEQAISMDHDKRSIADSINLDTIVESSYDGPRLDEKISLEFMQHLIQTYKNQRKLHKKYAYKILLMIRKMFESLPTLVDIEVSVGHKFTVCGDIHGQFYDLCNIFELNGLPSEENPYLFNGDFVDRGSFSVETIFTLFGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVRSKYSSQMADFFTEIFNYLPLCHVINKKIFVCHGGLFGSDNVSLDDIRATDRVRQPPDEGIMCDLLWSDPQDIRGRSASKRGVGCQFGPDITNEFCEKNGIDYVIRSHEVKPEGYESHHGGKCYTVFSAPNYCDTMGNKGAFCTIRGDDLEPKFTSFCAVSHPNVSLVVSTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6M2</accession>
    <name>A0A158Q6M2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3907</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000214">
        <property type="protein sequence ID" value="VDN53934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6M2"/>
    <dbReference type="STRING" id="318479.A0A158Q6M2"/>
    <dbReference type="WBParaSite" id="DME_0001045101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001045101-mRNA-1"/>
        <property type="gene ID" value="DME_0001045101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001045101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43496" checksum="093FC22A689EF910" modified="2016-06-08" version="1">MLFWNDNIETISAEIILIHPVVFFCIFMQIYFRGPLSTLHRAVHRASSKIFTVKSIDLQKYDAESGLTREDVDQEIEICARLKHPFLCELKDVIAGQKAVHMVFEFLDGDDICFEIVKRASAGFVYSEAVVSHYMKQLMQALQYMHNQGIVHRDVRPHNVVLASKDNSAPLKLTGFGVAIKLPAPEIVMRNAFVNEKLINLLNIIDICFFGRVGIPQFMAPEVVNDVEYGTKADMWSAGVLLFILLSGRLPFVGSRQSIYENITEGRYSHHGGTWNYISNAAKDLLIRLLTVEPRKRLSAEEVLNHEWINDRDRTAPKKHLQNTSNILNAVNSNRWLNLPSHESMLSILSGDSLPGGDTCDADGCTRRGPDQMVSEDISGVEKVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PKE8</accession>
    <name>A0A3P7PKE8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4673</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PKE8"/>
    <dbReference type="STRING" id="318479.A0A3P7PKE8"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="238" mass="27479" checksum="5DFAD5C0FB30E746" modified="2019-02-13" version="1">MQTTISSFIDTKWRIAICCLILLIIVVVIGNFFVMVIITCDQKLRRLTTNKFIASLAVSDLLVGIVVMPLSLYEKFYGNKWVLGFGWCQFHLITFIFSTTASIIHLVAISIDRYFAIMFPTEYQRHSITTSVVPYLIMIWGVSFAVSSTLLMEQNLDANDVCWIENSQYLVLSSLLSFFVPGVIVVYLYMKIFIQLHNHRLYMCGKISRQQGQEKTAKRSLPRVIIEEVRFLLFFIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PLP6</accession>
    <name>A0A3P7PLP6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PLP6"/>
    <dbReference type="STRING" id="318479.A0A3P7PLP6"/>
    <dbReference type="OrthoDB" id="6516201at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF59">
        <property type="entry name" value="LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="301"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="520" mass="58051" checksum="1F1F8C0D7DCC00C6" modified="2019-02-13" version="1">MDIKLVLECLPWQFDCQFGSPRCIAQYKVNDGAIDCASGFDEGCPPHNFVCADKSACVELSKYQDGVAHCKDKSDEPCPAGHFLCNDHSKCISGDQFQNGIEDCKDGSDEECTVTQFECKCGSPRCIDGNMVKDGKNDCEGGSDEKPLDVCPGGKKARKSINSNKFQRPLNSKSFTQCKTNHGCRENLGEICMMVGGASHCVCKKGTIRPKGSTRCVPEQLLQQYINNIIANCSLIQNELIEAYGKQVKSNEGKVQFKEEECNPKKPNACKGHGEICVIDANGRSRCRCANNGTRSGGICLVNECANPNLNDCDPNASCTDSELSYECFCNEGYIDVSSLPTTRPGIKCVKLVNECALSFKNNCDKNADCIDKPIGYTCRCKNGYVDISEGGARDPGRKCQKLVDECKTKLADCDPLARCTDLVVGYQCKCKDGYLDVSNDPINKPGRICALRNFTLKSSINYFKRFLKFDISKIYLYLKFIYIQYCKLAKFLFYFFKFFKRQTFVRYSSFSNNYLFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PVM2</accession>
    <name>A0A3P7PVM2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000155">
        <property type="protein sequence ID" value="VDN53628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PVM2"/>
    <dbReference type="STRING" id="318479.A0A3P7PVM2"/>
    <dbReference type="OrthoDB" id="9986177at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018145363" description="SAM domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="331" mass="38060" checksum="DA3050E910FDFD50" modified="2019-02-13" version="1">MIILLSSLFIRIFYVIITADEEKLRDYDGYSAIVQLHYEMDDDKSGSIDRIESTGFLKEDMHIGGDDRVTREKAFHHNNDELITVDDLWKSWVESEERSWTTQQMVNWMEHTVRLPQYSAILNSLSVNGRALPRMALMNSTYLSYDLKVKNSAHKRKIRLKALDVVLFAEKSSQLKDIALSILLVVLAIVLVIFNKHRARSKYEVDQLTSKLSQLKIMKSDFEDTQQRTCEFELNYIGQLRMDCLAEMREAIEHIDKLRKKQSSLVSSIKLATGASTGTDQIDSKIFSLKGRMEKISLAMSESYQRWIEIESLCGFPLFINAVSNDPLSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PY40</accession>
    <name>A0A3P7PY40_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PY40"/>
    <dbReference type="STRING" id="318479.A0A3P7PY40"/>
    <dbReference type="OrthoDB" id="10056860at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="472" mass="55562" checksum="BFD3479AD11DDF2F" modified="2019-02-13" version="1">MHLFCFKHFFSNCYIVSNILGNKRVSVFHYTDRKSGRGYSNFASTIYPNRPYIWPPFRKLYRWNFIFAFILVFASYESKFYGHSEPNIGENDREKKKKKKRKVGFRERRIIEYENRLRCYSSIDKIFRYFASIKKDSPSRPYEIFMTPEDFVRSITPGIMQPRNLGLDQYKTYEEYKRELVTSKGVFAKLGEYGLINYNDYLFLMTLLSASAKDFKLAFKLFDVNGNGELDKAEFEYVQELIMMQTMIGQKHHERAGLYNKQNLNSTLKSYFFGEDGSKKLSIDEFLIFQAHLHRDILKIECERRDAEFSGKGKISEVSFAEILLLHSCLTDVKKRVMLKRVKKKFGNNSNEKTGVTLDEIYSFFCFLYYIEDVDLALNFYNIAGAAIDAELLKRVARKVTGCHISDHVVDIVITLFDDNQDGRLSQKEFISIMKKRMNKGLRRSRDTRLMKLIGATNHCVVEQLKNSFYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q5J5</accession>
    <name>A0A3P7Q5J5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTF3C1 extended winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q5J5"/>
    <dbReference type="STRING" id="318479.A0A3P7Q5J5"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="2">
        <location>
            <begin position="177"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="298" mass="35064" checksum="B3C233444162475D" modified="2019-02-13" version="1">MLISFANLFFTYVCDYIVNNIFQKECAEIDDEKASSSKTSVHRKLCVEYQANHWSPQFLYRTMSDLTVAAIRLSGSEGSGRTEIGRFYGMNTRSKTGNRKVSRHIINALKLFPAYFGQYQKMEGRCRTLRYYYKFSSGPKSFNTLFAEWKNINGSDCPFTMGQVIKFPNANLSTLRISDVSLRRLMDIVRLIKEKSVIVTMARLHKKIIEIEKGYEYGHLIDKRSIRKCLKALEKVKLLHVFETTVRHDETQHKVYFHFFFSLIVFLIKLNYIFHNNSYFFHALIICYQYSVSSMYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q6T1</accession>
    <name>A0A3P7Q6T1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q6T1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q6T1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="31"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="399" mass="44272" checksum="8B111F4E7F60C680" modified="2019-02-13" version="1">MTSGWFGNVSMGPPDAILGVTEAFKADKNPKKINLGVGAYRDDHGKPYVLPSVREAESILLSENLDKEYAGIAGIPEFTNVAAKLSLGDNSSVIKEKRNATVQSISGTGALRIGAEFLVRPKVIYQPAPTWGNHIPIFKFAGFDVKQYRYYDKKTCGFDESGALKDISEIPEKSLILLHACAHNPTGVDPKPEQWKKIEEVVKMGNLLVFFDMAYQGFASGDIDHDAYAVRYFVQRGHNICLAQSFAKNMGLYGERVGAFSVICASEDEAARVMSQLKILIRPMISNPPIHGARLATRILSDQSLKKQWLVDVKGMADRIISMRKQLYDLLIKEGSTRDWRHIVNQIGMFCYTGITPEQVEKLVKDYSIFLTKDGRISVAGISSNNVAYLAHALYQVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q8I7</accession>
    <name>A0A3P7Q8I7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q8I7"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF191">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="299"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="864" mass="100383" checksum="02AFBA43B012107F" modified="2019-02-13" version="1">MSKKTTIDPQYVFSPENAPWRYEYEVLRQHWPLDEQNFWPGKSYDYNGYVDIIAAGIADKFKGRPNMLLENYLNELSRINQYIIYNLTVPFDHSGKHYEVGFTDICLSYEWKCYHNDHITMLMPKHRWGNFSGRLAEFTDDIIKNEVKITYPIGWRGTEPIYFGALIGAPNLIDEEGHFNYVRAIRLTYNVRNGKVGDISYRWRKKVTSYLANKENPPSRILEFGLYHNESLPEGLQQVADELIPTFICTFAILFALCALNAIVFLDHSNYLAVDWVRSKPVTTIKFILPIMTLLTDFFLYLTGYIIQGIGIDDMFIMTAVWHRTNPNLSASKRLAVTLSEAATAVSITSITDLLSFGIGCFTSLPSVQLFCLYTTSGIFFTYIYQLTFFTAIMAFSGDWEAKGLHVITFKPAFDPNKASYRKRRNILYSPKQKNCIKLFLIIIQTNFSKDSSWHDDRDTLISKIFRQFYGPFLLDNLTKKIVIFIYMIYTSLSILGCINVKEGLNPKFLVKETFYLNKFYVLMDETFWNEGLQMQLVVNSPPDFFNLSQKANFKSMISEFENTHYTMKHNATMFWLDAFELELKKQREEFKIPSPTTEEWYEKCQEWLIVAGGRRLWEKDMRWCTNQLKPFNHLCAFRLQLGLRNYRTPTDHMRSAQMMRKIAAKYPQFNISTFHEYYPFADQYIELKPALIRNCILALLSMFIVSFIMIPNCWAAFIIAGAILNIDIGVIGFMTFWEIRLESVSMITIIMSIGFAVDLSAHIGYAYVKADGDKNQKAIQALENIGWPGAFSTMIGISLLASIDAYIVQIFFKTIFLVITFSLIHGLVFLPVFLTIFLPHTYIHKKFDTIRDIEFHIKSENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QJF2</accession>
    <name>A0A3P7QJF2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS4880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QJF2"/>
    <dbReference type="STRING" id="318479.A0A3P7QJF2"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000429">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="65"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN54907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="401" mass="46259" checksum="81B9F564DA451AD8" modified="2019-02-13" version="1">MIFSMFDGTSAIRNVFLSLTKIIRQQSVDTGRRRLAISPHLGRPTRHVRIVDQHVNDKYVQLNQYRLMEEIGQGSYGIVKLAYNEKDKNLYALKVLDKTKLIKNFAFFPPPKRHKRAQSSMKDPMQLVQREIAILKKLNHPNVVKLVEVLDDPSDKFIYMVFEYVERGSVLEIPTDKPLREDITWRYFRDTLQGLEYLHFQKIVHRDLKPSNLLLSEIGHVKIADFGVSCEFEGIDAFLTGTAGTPAFMAPEALVEDSSLFYSGRAQDIWSLGITLYALLIGHVPFTDNYIIALHKKIKNDPVIFPENIFISDDCKSLILNMLIKDPGLRFMLHEIKEHKWVSMNGKLPMPSESENCQLITVTDEEIQNSLRVIPRLDTLILVKAMGHRKRFGNPFRFFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QME7</accession>
    <name>A0A3P7QME7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 184B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QME7"/>
    <dbReference type="STRING" id="318479.A0A3P7QME7"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="45287" checksum="C690A9C6A5256147" modified="2019-02-13" version="1">MDGFSNTSVVIMLTSTNLTITDDIFLRTRFARAVSGFFTWAALFITSYHIYQHLRWYSCPIEQRWIVRILFIVPMYSLDSWLSLLFLSNNVYVYFNAVRDCYEAFVIYSFLSLCYEYLGGESNIMAEIRGKPIRPTNYFTCTCCLTGKQYTIEFLRFCKQATLQFCIIKPIMACLTLFLMMIGKYEDGNWSGDQGYLYITIVYNVSISLALYGLFLFYTATRDLLSPYNPVLKFLTVKSVIFLSFWQGFLLAVLGLTSAIDPVYDVKGYEIISRGTVAAGWQNFFICIEMFFAAIALRFAFSVSGYIDTSGINSNIDGNPVTLQSISHSLKETMNPKDIMQDAIHNFHPQYQQYTQVYFMKNRSDILSIFLKSLCYEFIFVLYIVNKLRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7S9J5</accession>
    <name>A0A3P7S9J5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS1065</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7S9J5"/>
    <dbReference type="STRING" id="318479.A0A3P7S9J5"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="10"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN51092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48572" checksum="01527A0A78EECDA4" modified="2019-02-13" version="1">MSLPHIYRPALTYTDKEEPFVIYEGYCIDLLKRIAKLRKFNYILHEVKDKAYGSREANGKWNGMVEELRKGEADIAVASLTISFSRSEVIDFTVPYMHLGISILFKKPNPSNPSFFAFMTPLSSTVWIFMLMAYVITSLIIWITARISPFESASIDGNSVVSFSNQFTMFNSFWFTVSSLMQQGSELSPRALSTRIVAVVWWFFTLILISSYTANLAAFITAYRMVAPIESVDDLAKQTKIKYGTLGKGSTMTFFSESKIDTYEQMWKAMSSQPILNFVNSSKEGIHRVKSADYAYLMESSMLEYAIQRDCELMQIGDLLDQKGYGIGLPKGSPYRHAISTAILDLQEKTILTELKDKWWKKGRGALECENSKTTAGEMSMLSFDGIFIVLILIYLKVTGLIFSFTLAIIEWCIKMTYQRNVSKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SAJ2</accession>
    <name>A0A3P7SAJ2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">rRNA-processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SAJ2"/>
    <dbReference type="STRING" id="318479.A0A3P7SAJ2"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="23198" checksum="16F569646CE0FCA7" modified="2019-02-13" version="1">MKLKIGEFQKRMPWIETLDITVENEMNTIYKQAKKAAEIAIQRLKQMKMKVFRPSDYFAEMVKSDTHMQKVRQRIADIREGKERQENIRRLREEKKFAAKVQREVIENRQNEKKKLKEAVMKHRKGLKGQLEEMLNNAKSLQIYDDKTDATSHLKKKDNQMRNGVKCSKLSRNARNKKFGFGGQKKRSKNNTKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SCT3</accession>
    <name>A0A3P7SCT3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SCT3"/>
    <dbReference type="STRING" id="318479.A0A3P7SCT3"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="240" mass="28142" checksum="535D7DE1ED5AE494" modified="2019-02-13" version="1">MYNSKGIHLSQGCHISSFKYKLSCRKMFLYWSNITSDIDGMMGGFSNLHHVDILFSKRFIQSLRKIKKFEFKKFLYHHERAIDCGCGVGRITKNLLLPIFNTVDMVDITEEFIEKSAKYIGRENKRVGKKYISGLQDFVFLNNYYDIIWIQWVTGYLTDQDLVKFMQQCKNGIKKGGCIVIKDNVSTNDKVFYDDEDASWTRPKDQIVDLCKQSGLKMIHDKKQQNFPDDMLPVYMIAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SY93</accession>
    <name>A0A3P7SY93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SY93"/>
    <dbReference type="OrthoDB" id="25039at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="174" mass="19098" checksum="EF961C12DD575CC7" modified="2019-02-13" version="1">MAVNQSISSASFTCMKNSGFSTAFIRAYMPIADGMVDSNFVQNVYNALGLGTEVYAIPQAAGIKTAAQQFDEIYSCIKQSQIILHNIQVTSPIHWYWNVLGEGETGRTAADFSDFRSFAAFINPIIKTYARATRICGTSVDQIVYPQSYGLFSANSTDQNDKMIIVGSIQIPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0E2</accession>
    <name>A0A0N4U0E2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4377</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0E2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0E2"/>
    <dbReference type="WBParaSite" id="DME_0000001701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000001701-mRNA-1"/>
        <property type="gene ID" value="DME_0000001701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF28">
        <property type="entry name" value="BUB1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000001701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39646" checksum="D976F6649F5F693C" modified="2015-12-09" version="1">MVDKEHYWELNRENIKPLRGGRNVHAINHVFSGNMLPIAEAHLKFESDLKLAEASDDPVDICLKYVSWFDEQYPSGKTSHLNRILTTMINKFGYMKKYTNDERMMKLWFKLADNSTTTSPDAFLERAFIAGCFRRLSAFYVRWAEFREIVGDIDGARNILQRGRDCFAEPLSLLNDASDALEMRQIQASLVNHTVDHLDEYEPRRIALGGISGIGPNATAPPLRLSSKVASGLSNGKNITTSTENSNKFYVFEDNEFCCDKNLLVPQDFGDSLAHIQLVENTNEPTKWKDARIENLENVGRQQAATFAVFDETSVYEPRENIFKISGVLAVVDKVLFLTYAPIFDLLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0G6</accession>
    <name>A0A0N4U0G6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4406</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0G6"/>
    <dbReference type="WBParaSite" id="DME_0000004601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000004601-mRNA-1"/>
        <property type="gene ID" value="DME_0000004601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000004601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5979" checksum="46C0FA4438DA7ACD" modified="2015-12-09" version="1">MKTDVCKLETQRLVCNNNQKIVDDLPNKCPFYGNFFVVIFCSSNILFINYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M2</accession>
    <name>A0A0N4U0M2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4468</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0M2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0M2"/>
    <dbReference type="WBParaSite" id="DME_0000010801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000010801-mRNA-1"/>
        <property type="gene ID" value="DME_0000010801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844208at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000010801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1693" mass="188788" checksum="EFFF6DEBB01555B0" modified="2016-06-08" version="2">MLSKDTGQLFLKVERGKKPNVQVYEEERKIKVIVPYDQSTKWPIIHARMSGGLTISVQRLQQQYKITVQHNLQRKPDVSVYINTSGCDGDLKTCVRDMSTQLEHIGVAGPNLEISGRIKAMKVSFESTVGALHTNAKLQANSVTISAQHVFIQPEAIYFCSKIRIFSRHVQIDGRISGYNEDSKIMTVNVESSVLHLGVDAVIGSLKAKDKSTNKSLDRNVDVLLFHLSGNLANFGRISSKSELEFRIGGSILSLKDGHIDSAVRGYAALKQIKGVVSDISDSLPTSSTLISAIVSQDPDAVAQLLENGVDPNDSIGDQLKVCNPRKIAAMKYEEMRITELRNKMREKITLIQALMSTHEWRRGTIKSALIVASVGRDCADCAQFRASNLFLTVRGFAKCEEDSIWASGQVKHHNIEISCAGNVVTIEEGIISQKHCAHIKAVSFVCAGIWSVGDEIKMEFQSATFLKNSFIEVDLLSCNIEESCHLGGTWQVGSLKASLGENLLLLPTGKVLVDEIADVDAMTFNCNGFWRVNASNNLKLKAYLNIFPSAEMIVGIMKLFIEGYCSIAGYLAAENILAYVRKEMKTTSTGGVNIKVRGTIIAGAFRNNSNWHSEGNLTLNLACCEQSEDAIIMAKHTLNLSIYDDSEEDCCGRFFAGNCIIKAAKKVRIDGYIRVNHMEITIPYLNESCFTLGGQLEILSGPLILKGKSELYEVPSSVPHPFPAFILEGQLKAEAIIAPFLSVRFNSASYALLSGIESIINADYRTMISAGYLHTMRASLIDSCSKDNYPEAILCATTWFHEGHVRFHGEMVHLVLDTLINWGRLANEGKLQNHMKNVRVFVENYFKNESVFSANKIDINGNGKLENKNRIFAVDSMNIQLSNFSKADEYLSTKSIKLLSVSNECSKMNNSRTEEKENLELSESKLFNVMKRFGLNHQIRINAQAELLISSDVKNDVGNLALAAREVIIFESQFIVDNLELTLGPSYETEIIIRKGSNICSNQLRLTGTCKYLTFKIYGELNCESIICEESLKNIRILGPGSIICRRSFNASSETISFLINQIQILEFLCNSIKFIPKNCSKINAVDESKTLTVYADEVHFSGILIVEPRINLKCNSGSVHIVGELTGMTAKSELCIECGDLLLDGHLSNFDFLEIYARKRIDYCPMATIKNSRNIAMEAAYIIFCGTSTECRSLTATADEIVIRGTLSGHDIVCDCAFFAKVIRFEGFANRISKLELNSDDVYVAGTLKRINLFEIDSKFVRCGAEILECNNLKIVGSLLILGGRIRIDSLVCFSVESAIVCGHLFVAESAQLWASFVVFLGDNISVPQKTEINAVFWVTNQQNLLINRDKINMNILIDSNATNKIFRHELESFMRLIKMFENVFNSSIDDFRQTQLHSEQCSVLESINQSLPVDCEFATMLQEIVEITTYQHVRIFNIRKLIKVLRDSFSQLQIDEDMTHYKQNERFMAESVVALLNRLFTYSKKHTNETNTPKLSDDDGGYVSRSSSEDIEERQEISSIRSTLCEQPLMKTHCQQIDELMEIYKNAENMRKKFIVQKVTSSLDGDILSSETIDGSRMEIGCSKAGFVQNGERLVMIGFIDFAGLDAAVLHPQSNLSKSADLNADLAMKKLKVKQALSRFDLKSFKSESSLASFDANERKVPKNRIIPSPIKKSQIPRSAVCRLAISRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0P9</accession>
    <name>A0A0N4U0P9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="10">HMG-CoA synthase</shortName>
            <ecNumber evidence="3 10">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4496</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3 10"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0P9"/>
    <dbReference type="STRING" id="318479.A0A0N4U0P9"/>
    <dbReference type="WBParaSite" id="DME_0000013601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000013601-mRNA-1"/>
        <property type="gene ID" value="DME_0000013601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="12">
        <location>
            <begin position="182"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000013601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41884" checksum="C4AF3F5947938FE2" modified="2015-12-09" version="1">MNSNIAEMSPNLVGIRAFELYFPRTYVNQNDLEMFDNVSSGKYTIGFGQEQMGFCGDHEDVASICMTVLSKLLNNYDIDTKNVGFLVVGSETLIDKSKSVKTQLMDMFGDNTDIEGVDVKNACFGGTQALFHAIDWIYANWATEERYAIVVMGDIAIYEAGPARCTGGAGAFAALIGPNALISFDRGLRATFMTNEWDFYKPVIGQTTEYPQVDGVASLKSYFRSLDAVYSKYYINMSTFDALFFHSPFSRLVQKAFGRITYGDFIRKKQNYFKSKAIDRLAIIAASEDMWELKCDPYLFFNRRVGNMYTSSLYAQLVAFFHKSTCIESVIGKRLLFFSYGSGAASAMFSATVGDVDLSNSGIKSLVLYDRSEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U134</accession>
    <name>A0A0N4U134_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4649</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U134"/>
    <dbReference type="STRING" id="318479.A0A0N4U134"/>
    <dbReference type="WBParaSite" id="DME_0000028901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000028901-mRNA-1"/>
        <property type="gene ID" value="DME_0000028901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162701" description="rRNA biogenesis protein RRP36" evidence="8">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000028901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="39225" checksum="F8D50FBD687449F8" modified="2015-12-09" version="1">MVLTNVLMLAAAVGSDCSKCSGTVISIYFATKVMEKDDSKGTLRTFPKKRSHENRERRSKFNQSSRSISDTYFEEFSRKSCVDGSEENDDQSLYTSDNSEENFSGDEEIAVDSSGEIRKEIANMPLFQVKSMKEKLGVKLFNQTFFESDHSKSIKSTKKPEIIKPRDHPRRPREVSSKIPVPKFRTVYPNERINKQKFDPRFEDSCGLFNEYIYKTNYSFLDELQQNEKKILSDELKNAKLLDKKKADRLRAALRRLTDKEKSKIEAERRKDVVREVRKENEERMRQGLKPIYYTRGQLKRRYMEKKFEELKKTKKLDKYLERKAKKRNRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1B0</accession>
    <name>A0A0N4U1B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sen15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1B0"/>
    <dbReference type="WBParaSite" id="DME_0000038001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000038001-mRNA-1"/>
        <property type="gene ID" value="DME_0000038001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843641at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000038001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7855" checksum="8548A7FE4ECE235D" modified="2015-12-09" version="1">MSLIPLENSITGAMPVIFFEAQIHGQSQKILMEIGLSLDTDQCSVALLSDCTSNALIYYEQYGKNLQTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1D5</accession>
    <name>A0A0N4U1D5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4772</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1D5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1D5"/>
    <dbReference type="WBParaSite" id="DME_0000041201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000041201-mRNA-1"/>
        <property type="gene ID" value="DME_0000041201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000041201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42835" checksum="087A81A806076C6B" modified="2015-12-09" version="1">MASYALALFYWGWLGDRVNSRNVLIIGMIGSAVMLILFGFVPKWRNFYSYWYYILIYILFALFQACGWPNVIAIMGNWYSGSNRGFVMGIWCSCQAIGNIFSSLLIALILPFGYEYTFLLNSSLMILVALFVFLIENAPRRCSVPSFNNTHDEDSLNRTGRHLGLFEALLLPGVIPYSLCTACLKLVNYAFFFWLPLCLSARFGWTEQSANFLSIWFDIGGIIGSMLVGVISDRCGCKSPIVVLILLCAIGALFLYTHVGGNVFVNALIMTFVGFTVSGPYNFIAATISIDLGSQPLFSSNAEAMATVSGIVDGIGSLSSAFGQLIIPLIEIRFGWDYVFYFFIILVILSIFPLLRQCFADLKTFWMLHEEGANAQNETEPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U216</accession>
    <name>A0A0N4U216_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAC3_GANP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5048</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U216"/>
    <dbReference type="STRING" id="318479.A0A0N4U216"/>
    <dbReference type="WBParaSite" id="DME_0000068801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000068801-mRNA-1"/>
        <property type="gene ID" value="DME_0000068801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="297"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000068801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="560" mass="64952" checksum="9BAF24C535BD200C" modified="2015-12-09" version="1">MIPVPSESLSDSKIQQPNAWEIAQEALKKVTPSASSSSAFPRMSYAQSFANPMQQYYSWAPSYGLSLPVLPGYENMYASFYASCSGNRFSPPLPPPPPPPPAPPQAVYRSKNIPTSIASSNEVSRPLRMSFRPVRYMERSYLALEKAEDRDKLEEYFKQKLNPLLISGAYKAVDWQKEPLPSELNFEVKNQWTPASELKKLNSENNSLHDKISRTSRSPPSDIEVHRKKKKQKRPSDLDRSRDRSNYSDIKSTENEKIFKEAHSKKKKKRKITKWIADEQSNSRREERAKRFARDDESAKKIRQSQLRHDDNDSTTTIVGTSTEIEKSYFRLTTAPDPSMIRPLHILEKALKIVQQRYSENRDYRYASDQLRSIRQDLMIQCIRSEFTVKVYETNARIAIEQGDREEFNQCQSQLKLLYKEIPGCLNEYEFTSYRLLYYISVANTIDQTTLLLELTPKARKDECVRFALEIRQAWALSNYIRLFKQYSNAPRMASYIMDLFIEKERKEFLNACLKSALSQKICLSEPKLIEWLATFGIVISENNIIDCRIYSKALDKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U220</accession>
    <name>A0A0N4U220_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5052</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U220"/>
    <dbReference type="STRING" id="318479.A0A0N4U220"/>
    <dbReference type="WBParaSite" id="DME_0000069201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000069201-mRNA-1"/>
        <property type="gene ID" value="DME_0000069201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000069201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20485" checksum="32EB23AFFCB44874" modified="2015-12-09" version="1">MPFGSLYNVLHEQSAIVIDQLQAAKFALDIARGMSFLHSLDPMVLRYYLSSKHIVVDEELSAKISMADTKFSFQEVGRLYSPAWMSPEALQINPAALNIRTADIWSFGILLWELNTREVPFSDLSAMEIGMKIALESLRVPFPPGISRNMGRLMNICLNEDPGRRPNFDQLIPILERMARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U266</accession>
    <name>A0A0N4U266_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5105</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U266"/>
    <dbReference type="STRING" id="318479.A0A0N4U266"/>
    <dbReference type="WBParaSite" id="DME_0000074501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000074501-mRNA-1"/>
        <property type="gene ID" value="DME_0000074501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000007">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="268"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000074501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55970" checksum="98B6A2AA8CAA832B" modified="2015-12-09" version="1">MVLIGASVITKAGKPLFARIFISDMTKARLEGLLDAFPKLIASEKCEFFAQRQHTFVETDSVRYVFHPLDNVYMVLITTKASNILEDLETLRLFSRVIPEYCRSNDEKEILSNVYDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEERVFNQIKIAQERAATEVMTQKANELKKLKAEQKKAMRGIALSGMGIATAISSSTPTSVPIEDSTVRHAPKSVIPSSRGGGKALKLGSRTADEDQFLNQLKIAGTKISSDDYVGATTASRLPVHLKLEEKINAVVSRDGGLESFEIIGSASLLLSDPEFNNIAIQMVNGDKYGAQLQVHPNLDRKEWQQNSLLRLKSAQKPFPVNVDVGVLKWRLQLTNEESLPVSINCWPSENPDGCVVNIEYTLQAEHMTLNNVLITIPLPPATVPVIAECEGSYEYIKSKSQLLWSLAVIDGSNNCGTLEFNTPNGRTDHFFPINLRFWSADLFLHKMTSNDAMQYSCESRLITEKFEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2G5</accession>
    <name>A0A0N4U2G5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5228</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2G5"/>
    <dbReference type="WBParaSite" id="DME_0000086801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000086801-mRNA-1"/>
        <property type="gene ID" value="DME_0000086801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000086801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9368" checksum="50AC2255E9A93DBC" modified="2015-12-09" version="1">MNGLSRSSFDYFPIAFLDQLMNRNIRLLLDFVERLNTHNSNIFRRMYSENEDLRFKSLDRIELFAFFVDYCSRSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2J5</accession>
    <name>A0A0N4U2J5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DME_LOCUS5263</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25 27" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2J5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2J5"/>
    <dbReference type="WBParaSite" id="DME_0000090301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000090301-mRNA-1"/>
        <property type="gene ID" value="DME_0000090301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="24">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="VDN55290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="DME_0000090301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15221" checksum="E144DA22B7CB48DB" modified="2015-12-09" version="1">MANKYLSVVKKAYDTYRAIQVISASEGRVKIEFQVAEEHLNPMGTLHGGCTATLVDIVTSTALLATEKANPGVSVDLCISYLSAVKLGETIIIDASVLRSGKNLAYTRADVLRKSDNKLLATALHTKAFPLISQNNQIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2L5</accession>
    <name>A0A0N4U2L5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-related protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2L5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2L5"/>
    <dbReference type="WBParaSite" id="DME_0000093001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000093001-mRNA-1"/>
        <property type="gene ID" value="DME_0000093001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875961at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000093001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10859" checksum="7480F9B03AE3F8A9" modified="2015-12-09" version="1">MRGRLFNNIILIGGNSLFAGYQRRLSLELRSHVDDIYNIGFRDVPNPITHAWQCGRDAFCANVSKDRFVTKEEYNEYGIDICIKRYFKFFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Q8</accession>
    <name>A0A0N4U2Q8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Charged multivesicular body protein 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5339</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Q8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Q8"/>
    <dbReference type="WBParaSite" id="DME_0000097901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000097901-mRNA-1"/>
        <property type="gene ID" value="DME_0000097901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000097901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24990" checksum="3EEE5EDD7FFC315B" modified="2015-12-09" version="1">MEFLFGRRKTPAEMLRQNQRALNKAMRELDRERARLEMQEKKIIADIKKMAKMNQMDSVKVMAKDLVRTRRYVKKFIMMKANIQAVSLKVQTLKSQDAMSQAMRGVTQAMKNMSRQMNLPQIQKIMMEFERQTEIMDMKEEMMGEAIDDAIADEGDEEETDAVVSQVLDELGIQMNEELSALPNAQSVLSPADGKKAQAALSDADADLQARLENLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U358</accession>
    <name>A0A0N4U358_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase_M10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5511</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U358"/>
    <dbReference type="STRING" id="318479.A0A0N4U358"/>
    <dbReference type="WBParaSite" id="DME_0000115101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000115101-mRNA-1"/>
        <property type="gene ID" value="DME_0000115101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF295">
        <property type="entry name" value="PEPTIDASE METALLOPEPTIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M10 metallopeptidase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000115101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19082" checksum="D1013A2587471248" modified="2015-12-09" version="1">MSELNIDNDLVEYSYQKQRICNVQMDEHNVYKRYVLNEKKWPTDKISWSFRDPFHLIKKQIQFYSIKKLIENALKLWSEASNGTLNFQDKSPLYGFNDQIGNLDIFFAKYDHGDKESFDGLGGIVAHSTYPLSGMIHFDGSEIWSTNGQNDDRLDLRYVCLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3S2</accession>
    <name>A0A0N4U3S2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5743</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3S2"/>
    <dbReference type="STRING" id="318479.A0A0N4U3S2"/>
    <dbReference type="WBParaSite" id="DME_0000138301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000138301-mRNA-1"/>
        <property type="gene ID" value="DME_0000138301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="185"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000138301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39562" checksum="4DFA36EA38A7EE2C" modified="2015-12-09" version="1">MSKTAGTAERYYRSLNEIYRVAGFCLADKDFEKAFIYYMRFICGIKINAEDMFCSLALEELPNHRNFQGFSSAEKNKAESSLQNAVQNAEMLKKLLKTKFEQDATQAQLHVISLENIQPAAEGSRSDWQSLTDENEKAKIINANVSTDHIKFSLLGNYDKPGKELKTQDSSKNQSDIEKLGFKGVVIAGDLIEKFTKAAEGNTKKNVETCAIICGLPAKRGVCQITHAVIPKQIGASDSCNTFNEEEVFAYQDSNNLITMGWIHTHPSQTAFLSSIDLHTHCSYQLMMPEAIAIVVAPKYNEIGLFRLTDRGMVEIGECRVPGFHPHQDSSLFYYCCEVRFDTSVEAALVDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U417</accession>
    <name>A0A0N4U417_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5858</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U417"/>
    <dbReference type="STRING" id="318479.A0A0N4U417"/>
    <dbReference type="WBParaSite" id="DME_0000149801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000149801-mRNA-1"/>
        <property type="gene ID" value="DME_0000149801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870077at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="144"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="364"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000149801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61777" checksum="1FB13162ADD078FF" modified="2015-12-09" version="1">MIWREKYFSDLSDNGLAVCVEDGSIFGNTSLPSIHTLKFASNRIRTVPSRAFENFPDLQSLDLTDNPIASIQEGAFESVHLKNLYINTSSLVCDCELRWFPKWLSSSGLDRSTISTVCLHPTFLQGIDITMVDVSNLTCVDNSPRVRLVKHPVPSTKALLGSIVQLHCMGYGASPLEITWKVIKSGVHRILIHDPTTDFYFNRSNSINVLKSFNRISGSNGISLEYLSSEMKLSDITFTDEAEYQCVVRNHFGSAYSLKSKIIVYQLPEFLVSPSNVSIIKGGSAKLKCSAHGVPPPVVKWRKDGGEFFPAAVERRLHVKSNEDTLYVINVSLADAGLYTCHVSNEAGNIEKSAYIFVFEDFRPQLEDRRVVSGMTVFFTCLTNEQPQVRVEWLHNGKRIDPLTAPSHMTFKADNQILVINEAHTSDSGSYGCEYKVGPDVLKTANAKLIVDVSSDDWNKCRGAVEVVAVKPNLYIIIAICTSFFFVVFSPIICIFLRSRKQKNMHRYSSVEVNLYLHISVQKTISDAAKSKMVIGSTGCDRIHLQGFSLQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4P5</accession>
    <name>A0A0N4U4P5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6125</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4P5"/>
    <dbReference type="STRING" id="318479.A0A0N4U4P5"/>
    <dbReference type="WBParaSite" id="DME_0000176501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000176501-mRNA-1"/>
        <property type="gene ID" value="DME_0000176501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000176501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32082" checksum="BB39548ABA75C77D" modified="2015-12-09" version="1">MTIGFITTAELFSNEEINKIIQEKKYDWRISPANGGIRAGFKPVEIEVNVLIRSISRIDDQNMEYETQITLRQSWMDSRLVYGQNDDNKPEYVILDAGQQIWTPDTFFPNEKKSYKHLVEKPNSMIRLYKNGTILYSTRTTLVLFCDMFLQQYPMDTQNCALDIASYAHTTSDITYSWREENPLQLKQHALTASSTFYLRNALSDSCTSESETGIYSCLRIWLEFKRLSSWYVIQIYIPSAMLVILTWVSLWIHHNGINFRIVIATLVLLTLTVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P3</accession>
    <name>A0A0N4U5P3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6539</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P3"/>
    <dbReference type="WBParaSite" id="DME_0000217901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000217901-mRNA-1"/>
        <property type="gene ID" value="DME_0000217901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF411">
        <property type="entry name" value="LD23667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000217901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28924" checksum="9D96E143892ACEE1" modified="2015-12-09" version="1">MASKDENDEDYSDLIAKITNNIQQLNQYVQRLETLTKRADVDSKEEFQSVLSLTNDLSKETNNLMKELVNASNSKRSPSLKIQRERLMNDLISILNRYQYIQRNISYMKKQSIQQIQFQNQQINEQLNENISNQEISNKEQLQLQQEHYLKEIKERNEMMKQLDSEIGDITKIMKDLARIVHDQGETVDSIEANVEHTAMYIQQGSADLQRAVVYQQKAMQKKLIIFIFLILLLLIISLILYFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6L5</accession>
    <name>A0A0N4U6L5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein LZIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6933</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6L5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6L5"/>
    <dbReference type="WBParaSite" id="DME_0000257301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000257301-mRNA-1"/>
        <property type="gene ID" value="DME_0000257301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262856at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040065">
        <property type="entry name" value="LZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505:SF8">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="2">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17348" checksum="D96B8E00A917D5B3" modified="2015-12-09" version="1">MSDAKLFANVQDHLNRLLLQLSDIENSKESLDDAEYIEMKKETIDQLKAIRAAISEAFRTPEIIAIFAKKEPTSLRQKLLQFEHELQKRKITSDTFNQRKAEILYALAQLRDELSDDEIQFLSNYSTIPLSLFEPAPIQTVLNVGNVNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6P4</accession>
    <name>A0A0N4U6P4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6970</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6P4"/>
    <dbReference type="STRING" id="318479.A0A0N4U6P4"/>
    <dbReference type="WBParaSite" id="DME_0000261001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000261001-mRNA-1"/>
        <property type="gene ID" value="DME_0000261001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985978at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF327">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000261001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="28998" checksum="7DF319FA605AAA1D" modified="2015-12-09" version="1">MEENRERAYKAVAYSAVTFSLISILSVCITMPIVYNFVDHVQQQTKKDLQFCKSSARDIMSEVTKKQPVSIAASALNRTRRQVGSCDNCCIPGHPGRPGPPGSNGKPGTPGPPGQPGAPGRPPVVCEEPEIPPCNPCPPGQPGPPGPNGIPGNSGRPGPPGRPGNNGRPGQPGPVGPPGQPGQPGNDGERGEPGRPAPSSPSIPGDPGQQGEPGPPGLPGPDGSPGRDGQPGSPGPNGPPGPPGPAGNSGENGEPGPPGHPGPQGERGICPKYCALDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6T5</accession>
    <name>A0A0N4U6T5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7015</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6T5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6T5"/>
    <dbReference type="WBParaSite" id="DME_0000265501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000265501-mRNA-1"/>
        <property type="gene ID" value="DME_0000265501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="13">
        <location>
            <begin position="47"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="464"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000265501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="67983" checksum="0D571BFA68C942A2" modified="2015-12-09" version="1">MSPLSLRGGQKKGKSKKWKIYLQFPHYTECTYLRSEIDVTYNYVVEKQPIGKLLFEQYCNTVEKYSKVWSLLLKIEDYETSDDDKDRRVYLAKLIAQSLSDSHEIATTSTEPSWYNFLPETLIAQLTAVDDISFQGSEPHEIYSRAYQNIRIYLAIEPFKDFIETNYFLRYLQWKWLEKRPVDKHTFRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRIKKRHAETLTLNEKQILQRINSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFEEKRVQFYAAEIILGLQHLHRERILYRDLKPENILLDDYGHVRISDLGLAVELRDNEPIKGRVGTVGYMAPEVIKNERYSYGIDWWGMGCLIYEMIEGKAPFRQRKEKVKREEVERRVKEDQEKYSDKFSEISRTLCRGLLHKEATFRLGCRTVGKPEEGAEELKAHSFFTQGDPKTGREPMPWKKMEAGKVTPPFCPDPRAVYAKDVLDIEQFSTVKGVRLDANDNHFYNKFNTGSVSIPWQNEMIETECFKELNVMEVNGVPVADLRPLDSSDEALKMSNNNKPSLFARIFKRKVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U788</accession>
    <name>A0A0N4U788_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS67</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U788"/>
    <dbReference type="STRING" id="318479.A0A0N4U788"/>
    <dbReference type="WBParaSite" id="DME_0000283801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000283801-mRNA-1"/>
        <property type="gene ID" value="DME_0000283801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000283801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="47841" checksum="C109086E69FA4A63" modified="2015-12-09" version="1">NNSDKVISRQATINIGTIGHVAHGKSTLVKAVSGVHTVKFKNELERNITIKLGYANAKIYRCSNEECPRPGCYRSAGSSTPDKFPCQRPGCGGEFKCVRHVSFVDCPGHDILMATMLNGAAVMDAALLLVAGNESCPQPQTSEHLAAVEIMQLKNLLILQNKIDIIKESQAREQYDQIKSFVQGTVADGAPIIPISAQLKYNIDVVCEYICKKVPVPIRDFTSPARLIVIRSFDVNKPGSEVENLKGGVAGGSILRGTLRIGQEIEVRPGIVSKSSDGRVQCRPIFSRIVSLFAEQNQLEYGVPGGLIGVGTKIDPTLCRGDRLVGHILGAVGTLPDIFTEIEIAYYLLRRLLGVRTEGGKKAAKVQKLGKGEILMVNIGSLSTGGRVIAVKGDAAKISLTDPICTEVNEKIALSRRIEKHWRLIGWGTIRRGVTIKPTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U790</accession>
    <name>A0A0N4U790_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS69</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U790"/>
    <dbReference type="STRING" id="318479.A0A0N4U790"/>
    <dbReference type="WBParaSite" id="DME_0000284001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000284001-mRNA-1"/>
        <property type="gene ID" value="DME_0000284001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12550">
        <property type="entry name" value="RRM_II_PABPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000311">
        <property type="entry name" value="polyadenylate-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000284001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22016" checksum="1457A211D3D9A539" modified="2016-06-08" version="2">MEFLDGSNELIDPSDTLNEEPDMEALTSRMKEIEEEAQLIRRMQNDVEKQMNLSSSSGLTSPTALSLEEKIEADARSVYVGNVDYSSTAEELEAHFHGCGSVNRVTILTDKFSGHPKGYAYIEFADKESLATALALDESLFRGRQIKVCAKRTNRPGVSTTNRPPRSRGRSGARVIVKYIYGGGYRGARSRDGFRCYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7G7</accession>
    <name>A0A0N4U7G7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS157</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7G7"/>
    <dbReference type="STRING" id="318479.A0A0N4U7G7"/>
    <dbReference type="WBParaSite" id="DME_0000292801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000292801-mRNA-1"/>
        <property type="gene ID" value="DME_0000292801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Receptor L-domain" evidence="2">
        <location>
            <begin position="47"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="2">
        <location>
            <begin position="366"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Growth factor receptor" evidence="3">
        <location>
            <begin position="527"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000292801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="842" mass="96364" checksum="07CCA7990428A9C4" modified="2016-06-08" version="2">MRKNIQSTLIENDRRNNLRKFCSGSKNSRAELQDFDRIDQLRRQYENCTRIYGNLEITHIQVEHLNEMKSPEKVFSFLDHIEQITGYLLIYSNEFTNLTLKNLEIIWGDERHDEIAAIHIVNNPLLKYINMPKLRSVERGTIVLSNNPYLCHWSGSVSFREILQENVNGRVQIDETNFDSCEKTDMLCAEDCNGRCWGPEPQMCQIFKSVKCIGKFVRQVVHPGCVLNQKMRQIAVMKLVLQDAMMKKAKPFVLEDFQESLKACAKLEQDSKCVEKCNGLTDYDRTRKMTVNHQSPRYTYDRYCVERCPDETLIQDDHCVIQCREGFWHDPDKSSRICEKCPNNVCPKTCKLEEAIDANNINSLWNCTVIEGHIQILRHTFQEHIKFRSINGEVIRERIKALTTNMLNALSNVRVVTDFVDIQTQEFSPNSLNFLQNLAIIEGRTLIEGYALTIYHNSNLAELRLKSLKKIKNGQIYIGNNQKLCYVETMHEYWSNIITAKNLPNEKPMFRIVGNQNQTLCEQLNKTCDESCDESKGCWGSGPSMCVDCKNFDIGGYCTETCPEIGYYKESEKICKKCDPQCFRCNGSSSLNCTECKKFVLQQGEAIECINECPITHYRSANYCLPCSSTCYHFGCTGNGDYAGEGGCNKCMHAQRGGCSTCGASNNLRCLIAYGKAKDVCKDNNLTNYYTTSGNMFVEQFECVECDPQCSFCTGYGNSVNYHHCQCTNYLVKTHSHNDYCAETCEINTFLLSNKSTNYPGECLQCDERCDSAYGCTGHSAKHCIKCAKAAIMLDETMVCLEECPLNKPYQAYDDKTCYEFDKQAVASKKLLFLLLLLENNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7U8</accession>
    <name>A0A0N4U7U8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7239</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7U8"/>
    <dbReference type="STRING" id="318479.A0A0N4U7U8"/>
    <dbReference type="WBParaSite" id="DME_0000308001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000308001-mRNA-1"/>
        <property type="gene ID" value="DME_0000308001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000308001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22086" checksum="4DE2689D00EB194A" modified="2015-12-09" version="1">MELSTVERTKIQCSFCSLFVKNIYICPRCKLFYCSKRCYRDKQHENCSEEFYRECVEDELKLMRNDSANSRLPLSFEEFMKKANDQETNNGIPDDAELLDSDDEDVEYLDEVMKRTKVDLDNVDEDDLDRQLLISGIGTDTEQLFAALNLSEKEAFEHLANQFYLEENDLEKSVFRSENRSKNIHGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8K0</accession>
    <name>A0A0N4U8K0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS243</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8K0"/>
    <dbReference type="STRING" id="318479.A0A0N4U8K0"/>
    <dbReference type="WBParaSite" id="DME_0000337701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000337701-mRNA-1"/>
        <property type="gene ID" value="DME_0000337701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF19">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="360"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000337701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="803" mass="91706" checksum="E6AE0F4827931C4E" modified="2015-12-09" version="1">MVDCPHITRSVCIARLDLEQLKRFGYGRYDSFKQKKMQITECDPQIASYRKKNTTTIDYGNWSCVECGTSKCPWLCLSCGLIHCGRYVNEDGLKHFKIYPNHSVCMDCYSYSVFCYCCDDFVGCDTDDHKIASIRSSLEFYNCSRSDDHSYSSTKYESTLDAEDIIEISATDSPPTFYDEATEDEGEFEGIFSSDYVQDEMDTLEVQMIDAAEQDENDSSRLRNIKNNRDSQVEFNLGSSGDEHEKDDCSESMSEADYADRKVIADLLENSRINSSSVLSNNQILNKHIFGQCDFMVSLKETPFIGGERNLRKRKRKIQLFTELKDGDLTGIQSLPLSTTVIGLPSCAEKGTAVDSKRLRGLKNLGNTCFMNSVIQALKSILPLYFSKSVSKQIFRYFMSRLPPLKMETFSTDGSSPQIPRYNTRNSLPFANERSFLTEELRKTLIEIASDTNSTSLIVNAYGPDALLAEVWKLVPRFRFWWGILAFAKVLCSAALIIVNNIGFQQHDAHEFLRCVLDRMHFELKSCRIPDWLLSEVCEGGVRLASESHFATNKRKKGTSKSERKCAIMAMFEGFLQSQLTCLSCNKTSNKQDPFLDLSLDIFLPSNGNRANTIHLNECLHRFFAKEELDTCEQYFCNFCRDKRPSTKQLFLRSLPNILCLHLKRFRWSQAHRGKLDNIVEFPLKGLDMKNFIYSENVNSNILSNESDSSVHGDSRSNSFSSCSSLTACADDYNALYDLYSLVVHHGSGEETTFRVSSGHYTAYGYHSKQWYHFNDSLVKPCSEQAVMKQKAYLLFYVRRNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Q7</accession>
    <name>A0A0N4U8Q7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS309</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Q7"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Q7"/>
    <dbReference type="WBParaSite" id="DME_0000344301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000344301-mRNA-1"/>
        <property type="gene ID" value="DME_0000344301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877987at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000344301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68290" checksum="0F22B42EBE589425" modified="2015-12-09" version="1">MVHLDDRIECEPKRDDRMEIPDFIRMFLNHRLITLSRDYFVMTPLYFYFLVSLVEFGECQQARQLARESSIVGLSRQLVAPGPEASKSPKVAVGPTLPIRSAGSELQRSIRPRVRTRIISRKLLRGKKSKRVRPFLSSQLNGSTGHLLDKLPFSLDRGVFSGKLPNIEPIRAESSIIASTSSTSPTVSGTNIQHLQLQMERRLSQKLSNGISIARPPVVNTDKSDKQDVIQNLPLTRNDEIPSQIDQTNSPSFLNSSAEITLSSFDNKPSNIPHDTTVFIDAHHVQLSSDAILATKEAKKEISSSLTVEALNNQAPNSLQQELQENTLFDDADSEILRKKVPSKKKHNIASNPPGFLPPSDSIINDLNKADDFMAVANVLQLKRRFKASMLEEKCLAYPSLTEYYNGKCYIVELKNKKTSAEAKNDRSICNHLDGYRANLAEIDVQTSDHLKSIGVINKRQPVFARNYHSEDIEPNEKYAYICQYADEFSCKSGYELSGLHCYKVYNNKETWKNAAKDCSKRSESLAVVHDDDTAQFIGSYVTESASPYIASYAFLHTRINNAAGEGVFGYMDIDKEIERKSYACQHIALHSFGQVVVPDSNLWLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8T4</accession>
    <name>A0A0N4U8T4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS337</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8T4"/>
    <dbReference type="WBParaSite" id="DME_0000347101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000347101-mRNA-1"/>
        <property type="gene ID" value="DME_0000347101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000347101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8179" checksum="D4B915ACFDEF6724" modified="2015-12-09" version="1">MRKLLWFSPSRDLLHQRYDSQELAVLIGVRAIQFVIKQMELENNDGSVSERVTKTTNSIKKGYLRYFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U959</accession>
    <name>A0A0N4U959_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U959"/>
    <dbReference type="WBParaSite" id="DME_0000360501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000360501-mRNA-1"/>
        <property type="gene ID" value="DME_0000360501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042791" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000360501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9644" checksum="58ABABA4535F1EB8" modified="2015-12-09" version="1">MACMCPLLYGLVSLSVFSESVLSRSFPSCAPGKPTRVLFSSYCNKSAVVALSTTEIDAQIFGGTYKRFYEAFIASKCIRTDRDGIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U976</accession>
    <name>A0A0N4U976_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7630</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U976"/>
    <dbReference type="STRING" id="318479.A0A0N4U976"/>
    <dbReference type="WBParaSite" id="DME_0000362501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000362501-mRNA-1"/>
        <property type="gene ID" value="DME_0000362501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820037at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000362501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13614" checksum="56A193D0E70087F0" modified="2015-12-09" version="1">MSHPNASQFVDVYDVSNLLEKMMQYWWNQVKTKDVSNTYKAKLADSFTQMAWAETEKIGCGTSKCDENGKYKQYLVCLYDPPGNQKDEPVYMEGEPCTLCRRYSGSVCHKDLCVGGESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9C9</accession>
    <name>A0A0N4U9C9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7686</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9C9"/>
    <dbReference type="WBParaSite" id="DME_0000368101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000368101-mRNA-1"/>
        <property type="gene ID" value="DME_0000368101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000368101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9621" checksum="0F30FE1C9CD41987" modified="2015-12-09" version="1">MELIHNNADASTNRLAIDTTIPLRQKKHHKRASKKTPYELDIVLSSVSICDIYGTDLRDLTISSAFGLNRNTAFVLEQYQSISDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9L0</accession>
    <name>A0A0N4U9L0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7787</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9L0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9L0"/>
    <dbReference type="WBParaSite" id="DME_0000378201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378201-mRNA-1"/>
        <property type="gene ID" value="DME_0000378201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33206" checksum="32576BBF87D8E6E2" modified="2015-12-09" version="1">MNINLFSDTVVSILDGAYQYSDNLLNCIGVGSYGHVYRGLDLAKGKEVAIKKLIKSDVKPNEIKVMKSINSRYLVKFIDVHISDINLYIIMELCSIDLEKHLQLYCERQILDDFNLRILTDNICQGYLALYNNQIVHRDIKPQNILITYDNNKNFESAKITDFGISRLLNEEKNGMCCNIAGTPEYMAPEIAANILKDSDYNHQVDMWSIGCLLYRCIAGHVPFDEAYLCKLILYSACSNYDAYDKPEMPEEMPDQEFINIVNSLLEFDPIMRTKPEEFHELALAWAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Y3</accession>
    <name>A0A0N4U9Y3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7933</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Y3"/>
    <dbReference type="STRING" id="318479.A0A0N4U9Y3"/>
    <dbReference type="WBParaSite" id="DME_0000392801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000392801-mRNA-1"/>
        <property type="gene ID" value="DME_0000392801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000392801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1161" mass="133514" checksum="9D3131DCA74A47E3" modified="2015-12-09" version="1">MNEDDEQKAYTWETAYADALNIREVLKEDESGSIEKAVAKLILDEKLKKRFRDRPANVRLGIIRYLYIIIDCSQAMTDKSLFPSRIMVTTKVLNQFLEKFSEQNPISQTGVIVCKDKRAEKLVPLTGNIRIVKEGLTILSEAFCYGEFSLHNSLMIAMKSLRDYPGHASREILVVVASLSTCDPCNIFSTIELLKRYNIRCSVISLAAEVFIFKKLCSITSGGRHNVIMDKVHFETVINDHTIPPIVRKNAESSVIRMGFPFHEIVKVPSFCLCHQSEAATPFGRGFFCPQCGARYCSLPIECRVCRLTLISAPQLARSFQHLMPLPAFEEVDITSETCFACAKTVEVKGFSCKECHATFCIDCDLILHDSLQICPSCSNQEPVTKKINPFDLKFNRVKRAVLDEKKQNLHVGTPGLSKKLANEKRQRILAAEWKNLKKTNKIIDQRFGENDRKISEEDRQIRRFTAERLKHFKTDKFQLADELLHLAEEVNLTHKGSALTSIEKYDRPVSDDEEEDGEIHSDIVTAAHFGGGKVEKDVFDQGSKRKDIIADLIMQTKQMRHEKQLVRDEIEDMTEQLDEKWRKLMASGAINNLAQKNANKANKSTNQSSDYYDRLLLELRSSNEKRGTAGERIKTEQEIAFEEKKRLDLLEKRRLSRVAESDPEVVSLELEAKNKRGKEKRLSANFEVKYDSDGNLIDSHKVEKAQIKVIQIGESFDDEEATNNNDENANVHTSDEVYDAMLNENGEIADEFTELENSTVDDLPFVFPFPKSYVDLRKLLDDHPASKCKLILDRIVKYYHPSLCEGNKKRLLHLFILLLRFYDDLSKESLPKIDTMGCLIKVLHTLLKFDTEHGTRCVRAVLRQQYRAHSKRLHLIFGFRFIALLKLVFCLFPVTGAFHPVCTPMLAFTCNLIANARIDCLKNAARMVCTRGNSTPTGVFFVGRKERGIRTVTDSYISNIFTSSENAFCREKISCFLLMVYMVLLQITDATLEIDIRATFDENPTRPICKLLSRLPRENYPIKLNEFLIEVKKLLEEELSRNSGITQLKRPRPPKKMLQFLEPSVDEGYGQKKIKKKLDKKTEIKNLTRKYKKEMRSTTLLLDKEKKKYILIYHESIFRLKQAEQAEKDRMRRLKTKQLIRSLQGQESEYKKNQYTKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Y6</accession>
    <name>A0A0N4U9Y6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7936</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Y6"/>
    <dbReference type="STRING" id="318479.A0A0N4U9Y6"/>
    <dbReference type="WBParaSite" id="DME_0000393101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000393101-mRNA-1"/>
        <property type="gene ID" value="DME_0000393101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF82">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000393101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42602" checksum="65307B2DA8B2FEFA" modified="2015-12-09" version="1">MRLFVSLGKESIISAVSKVGDWEIGDRCQIEKRIGSIVYIGPTNFAPGEWIGLVLDKPLGKNDGSVDGQRYFTCAPNHGLFCKASKLERIQSSVSEIIPENPYTKEFGFDVGDRVVVSGGKIGTIRYLGNTDFQDGIWAGIELDQPVGKNDGSVQIRHTKTSALRQRSGSHESLASIGASSIASSRISKFSFAPQRNIQRPIVLSSARGLDELVTTLQDSLKEKEKHLEQMIKERDLERNEMARLSNHCEEVEAKLALFEGQMTGSTHSAILEDKLINLKSRNATVEAENQDLMLEVKEKTEKIDELTFLLEEKEIMCAEISEKLAEVNKTDVEKKSKVRLKIILTLKNSQRIISSVKPEIFFSVNLNACHFLFFLSVDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA40</accession>
    <name>A0A0N4UA40_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS356</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA40"/>
    <dbReference type="STRING" id="318479.A0A0N4UA40"/>
    <dbReference type="WBParaSite" id="DME_0000399201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000399201-mRNA-1"/>
        <property type="gene ID" value="DME_0000399201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978072at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF258">
        <property type="entry name" value="CARBONIC ANHYDRASE-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000399201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32251" checksum="7537DD670CBF986B" modified="2015-12-09" version="1">MILTVLGPDFWGLVDKRWHMCSKGKIQSPINIDPSALLYDPNLREFHIDKKSVLSEIINMGQMPRIRIVNSARWPSVNISGGPLTPYNYRLRRMDIHFGRNSEKGSEHSIDMQKFPMEIQMIAYNSDLHQNFTTATTSPHGLAAISVFVQSRLLQIGEETNEELSKMTAATKSIEFRRKRVSIQELRPWNLLPKNLEYVTYEGSLTSPGCHETVTWIIINYPLYINKSDVSFCMNFSLNFKGSRILIQIILWRSSNSQCSKKTKKNGEFYEKNIFFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAU2</accession>
    <name>A0A0N4UAU2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="1 6">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8174</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="1 6"/>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAU2"/>
    <dbReference type="STRING" id="318479.A0A0N4UAU2"/>
    <dbReference type="WBParaSite" id="DME_0000429101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000429101-mRNA-1"/>
        <property type="gene ID" value="DME_0000429101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000429101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51931" checksum="CDE8BA4D9AEE2054" modified="2015-12-09" version="1">MKPLNVVDPQTFRSFCFRGQGCANFVISAKCRKSRFRIVWRFSKHRKSGTVTVKPKCHAIAAYLEKLIVPIIGREYLVKPKIVSFDVRNLHRLAKIPALPLNMKVESFDELCDERKYASSMSFFPLHEIPEGTRFVSALQMMDATRIPKRLPSRFYGPTITVEIKPKQGFFQNYSGIQLPYCLNCILQSVYFISVNCQLEKMNSNAFDVMYDYCPLDLFSGDIQRMRSALNSLILVPHRNLRIFFNGTVIHSDELSLNHQSLQDTLFHGGSVTIEELVTAICCVLVGAPSNAEFTVQDTSVLAKLLAAQKLDPVGIVKAYEIYQSLSLENQRELLNKCLLPRNDLSFMHENSDQALLQRYFLAATMKDCSVMISLRLIDETITSVPHSRCSPPPIVKIYPSTIQHPDACSVSFAYSIKLVDLDPKTPKNLLNSYQRFVDGVRFIRETHPMRRPCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC88</accession>
    <name>A0A0N4UC88_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">urocanate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS492</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-imidazolone-5-propanoate = trans-urocanate + H2O</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC88"/>
    <dbReference type="STRING" id="318479.A0A0N4UC88"/>
    <dbReference type="WBParaSite" id="DME_0000487101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000487101-mRNA-1"/>
        <property type="gene ID" value="DME_0000487101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000003">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10730:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055351">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003820">
        <property type="entry name" value="PRK05414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="10">
        <location>
            <begin position="109"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="12">
        <location>
            <begin position="332"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000487101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62170" checksum="E587A2DCD9DBD623" modified="2015-12-09" version="1">MILNNLDPAVAQFPQELVTYGGNGQVFSNWIQFRLMLHYLSIIDEKQTISLYSGHPMGIYPSHRNAPRLIITNGMMIPNYSTKELYDKYFALGVTQYGQMTAGSYSYIGPQGIVHGTTITIINAGRKYLGVKNLGGILFVTSGLGGMSGAQAKAAIIAGCIGVIAEISKDALMKRFVQGWLNLYSDNLDKIITLIREYKQNKQAISIGYLGNVVDLWERLVEETDLIVDLGSDQTSLHNPYNGGYYPAGVSFEEANKLMVENPEKFKTLVKKSLLRQIAAIDKLTKNGMHFWDYGNAFLLECARAGAKIFAAEAADDKTFKYPSYMQDIMGDIFSMGFGPFRWICASADPSDLRIADKLAYDVIKALANEKVPKEIQQQYLDNSEWIKQADKHKLVVGSQARILYSDLEGRIAIAKAFNTAVAEGKLKGPIIISRDHHDVSGTDSPFRETSDITDGSAFTADMAIQNVIGDSFRGATWVSIHNGGGVGWGDVINGGFGMVLDGSHDAEKNADSMLTWDVANGISRRCWAGNSLAKEAVHRAMKKIKRLRVTIPEAVDMKKLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCF9</accession>
    <name>A0A0N4UCF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8752</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCF9"/>
    <dbReference type="WBParaSite" id="DME_0000495301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495301-mRNA-1"/>
        <property type="gene ID" value="DME_0000495301"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="566" mass="63850" checksum="D7BB1FEBD9B2260A" modified="2015-12-09" version="1">MSLIINQIMRLGSIILVILQYSTVDVFHIGVFKLGQIFEDFGCLSTNVMCGTNMVFYKIEEDDTSQLSGKCLQRCSCLDTKYLEINGKCVQKELLYELVNDSECRLVGSSCGENMVLQIFSKFNESCVDICVCAKNFMENDIGCVQCDWDEDNHDDNDGDNNDNISSTTTSYPSMPPYRLGQRVFDAVCSLRDQSCGNNMIFETIRYSKHAFCTQKCVCDRNSEEKNGECVITNNSECAKNRKKTLENRNKVEIRYIRAGKSRLNEIFHEIECMLERHSCGPNMELVAIGLSPGNKDSKCIMQCQCAYGFIEANGRCSKIIKNIDKRINCMRGKCILNEVVQDVSCSLKGQFCGRNMRFVLIKQSVVRQHYISIGNCVVQCKCDKEYIERNGKCIREQGKTTKTKNICLLENGCETGMTVHDEGCHLTGKKCGNNMIFKVVNSTVRNETYSIYCTQRCSCINSNFIYSERNSGCEQQSTTVSSPTTTSHNIITVGMHDFEMYIGKEYNIGEEISDLGCRLRNRLCGINKKFIVVGEYAAEHDPTIRGCIERCSCIMAGPGGCMQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCM5</accession>
    <name>A0A0N4UCM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8824</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCM5"/>
    <dbReference type="STRING" id="318479.A0A0N4UCM5"/>
    <dbReference type="WBParaSite" id="DME_0000502501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000502501-mRNA-1"/>
        <property type="gene ID" value="DME_0000502501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5791600at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041642" evidence="1">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000502501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38072" checksum="33195747A46F8FB3" modified="2015-12-09" version="1">MSMALGNWTTAKNIPLFLAQILAGKTLLIGCAKSSCPMTNEGQETIVVCEYWPKVSKGPLYSQGKFCENGNDCTLYAKSTCNTETRLCDTGDDIELNEFLQPIYSPKNITESTNLVLDFTPYQLPDDDMITNSSHEDEEKYIGFKHDLHRLRFLNAHKERRNQILKGITTLDAMNSEQIEFFFQLTWSDELEKKAFSDAEKCESLEPKSSRKYHRIIMDSFDFDNLTYILDREFSMTVQKWWSNPMDESDENVIFLKNSIIGLFLATELGCGFASCVDDNLRMAIDIVCHYWPTSDPSELYDYAIGCERDGDCASLINSHCNIEEKICVKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCT0</accession>
    <name>A0A0N4UCT0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8888</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCT0"/>
    <dbReference type="WBParaSite" id="DME_0000508901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000508901-mRNA-1"/>
        <property type="gene ID" value="DME_0000508901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000508901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="28288" checksum="75897E1FFB4D237B" modified="2015-12-09" version="1">MASFLEEFAETLSNFPVEMHKHLNEIRKLDIECHKKALKCDEKMKEFVKTHKSQSKDVMINFHKEIMRTFDEIEKFSDKKIKYATELYELVDKYIRKLDSESAKRQASIKSKFIEAANKMKAENEKNDRKRKKGSTRKEKKKPKNEKNSEKNNASSSDLKPYLENAPIIEMPIDPNEPTYCFCHQVSYGEMIMCDNKQCPIEWFHFQCIGLKEPPKGKWYCERCNEERKKKPKQTSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCZ6</accession>
    <name>A0A0N4UCZ6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8965</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCZ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UCZ6"/>
    <dbReference type="WBParaSite" id="DME_0000516601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000516601-mRNA-1"/>
        <property type="gene ID" value="DME_0000516601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="132"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000516601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37784" checksum="EDA1256B0E630015" modified="2015-12-09" version="1">MADVVGFRKWQLHPGRNQFCCNGRIIMARQSSIFIITIFLILSTMTLFFIFDAPFLSMRVSPALPIIAAVLLLLVFVNLFKASFSDPGILPKATNMEAVELDRQNVSERNTSDTIRLPPRTKTILINGQNIKVKYCFSCRLFRPPRSSHCSVCDNCILNFDHHCPWVGNCVGQRNYRHFYFFIVLLTVLTLFIFCCECIHLTMLSKSDKAFLGAVKNSPTTLLVALICFFSIWSIFGLSGFHTYLLATNQTTNEDIKETFSSKRRPRIKNPYAKKTIFHNCCYALCGPEPPRFDYIYLILELFKFNEKNFNVQNYFHKILGFYWICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD01</accession>
    <name>A0A0N4UD01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ-loop repeat-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8971</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD01"/>
    <dbReference type="STRING" id="318479.A0A0N4UD01"/>
    <dbReference type="WBParaSite" id="DME_0000517201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000517201-mRNA-1"/>
        <property type="gene ID" value="DME_0000517201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000008">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000517201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13693" checksum="BAACEADDCFB483C0" modified="2016-06-08" version="2">MMLIERTAIEMLPLREVISIMILVLSSGFIIFGGAVPYVFQYMEIVERKNSQGFSLLVCLSLCIANILRILFWVGKRFDLALLAQSIVMFSCMVLMLEVSVRMNRRILHKSQYKSIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDQ8</accession>
    <name>A0A0N4UDQ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS585</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="14">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDQ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDQ8"/>
    <dbReference type="WBParaSite" id="DME_0000547901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000547901-mRNA-1"/>
        <property type="gene ID" value="DME_0000547901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF10">
        <property type="entry name" value="ALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="15">
        <location>
            <begin position="20"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN50612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000547901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="833" mass="94860" checksum="A7A7D80D94888609" modified="2015-12-09" version="1">MKRHRGIIKQVTRRYLFTKMSSSELRSSFLEYFISLNHTYVQPSSIVSHDDPSLPFTNAGMNQFRPIFLGAVEANSELGRLKRAVNSQGCIRVGGKHNDWEHVGRDLTHHTFFEMLGNWSFGDYFKEEACYFAWNFLTKILSVPPEKLYITYFAGNDKYALPPDYECRDIWKKIGVNPGRILPFGLKHNFWEIAECGPCGPSSEIHIDVQGSNDASASVNINGSSVVELWNLVFLQFNKEPSGLLKPLPRQHIDCGLGFERMTAVMQNVITSYDTDIFIPLLEEVSKYSNVGLYEGRVGEHDLNNKDSAYRIIADHLRTSCILISDGVRASVKGQGNVLRRLLRRAARASYLFLKADQGHLSNIVPFFIYHLKNSYPDMLKNDEVIEKVVKEEEEQFWKLRKEGEKRFHSVISQLPENSLILPGSIAWNLHNEGVNIEMASLLAEEKGLIVDMVGFEKEKALAQALSKSSFERRRTVVSDCSNQLTNQEIPVTNDLFKYNYSRSNSGEYSFAEIGGKILAIFDMNRRICNSLSVSKEGYIVVDVTNFFAEQGGQLSDTGILFDKNRQPVFSVKDVQRHKNYVFLIGTTLHSDLTVNMEIYQRINEGRRLSLMRNHTATHLLRYAIQKVCGTGVQQCGSLISAENLRFDCSLNRDLTPDEIAEIDLLINDIISSSQTIADRNVSIENIEFSQNDFPQKFDWNDLGANRTVRIIQIGDISIGSKFEIKEYCCGTHVLSTSDIQAFTIYAGETVGRGKRRLYAWTGTLAESALYIGTTMRSKISLLSSNMKVEDAKNFMKDYIGIKHKLPLWMKREMKESVRQIKKDIKKREKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEF5</accession>
    <name>A0A0N4UEF5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9353</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEF5"/>
    <dbReference type="STRING" id="318479.A0A0N4UEF5"/>
    <dbReference type="WBParaSite" id="DME_0000576001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000576001-mRNA-1"/>
        <property type="gene ID" value="DME_0000576001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="509821at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019176">
        <property type="entry name" value="Cytochrome_B561-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09786">
        <property type="entry name" value="CytochromB561_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000576001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74093" checksum="3126F18E3AF1E5C6" modified="2015-12-09" version="1">MAIHLLTSKIPRGTVEAALNYEASMNKFKVLSKSAITWAVLAFMLFGVFWSDCALATLLIGKILPLVNVQPIIRPLVMLILLFSCLNALVCAFFAAEKYWQNFRCYNQLAEQKNMMSTNARSGYKLSISFAKNTKFLFDWLSALRFGSAKSTPYRSAEIREGLMESLKAKVGFPKSSSSRPINSIQTSKQVQDFLDKSSFLDASVINCSSPSSNRFSHSGSFPQLQFNPSSTGSSTYQLGISMSEDDQAKASNDENGVVSLVTGTIVITLKKCSRIKFTSSRVSLSPIPLNLVDVPLDVTGGSPVDKNISNGASNINDDKEDNISFRVAHNASRNIAKKSVSSTPPTLQRSNSIERRKAMSPRTRHLANLSDSPFAALLSDTSPETNFSTFTRQIPLTSDEIMSQYKIDAKRFAIGERYLRIWISQTILCPLVSSIDDVNQILSKEYAHSHLKIGQSSIDALESAVSSKVDLLSTSLPYIIPYLKVHEKQAYVVERARTLAKDSCMKEYYWNSGGDEPLEFVKNGGFKAYNPTYGPWGEHLPTDAALIWSWFCVYFDTKLSVHPLAENLQGPFSSIYFLKKPFRPSAIQCSKDSFYIHQNNVHPPHFELVIRGGRERFEVGRGPRNLWRIILLFIQHARLFNNNCFGNVRLDETGANISWVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEL1</accession>
    <name>A0A0N4UEL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEL1"/>
    <dbReference type="WBParaSite" id="DME_0000582101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000582101-mRNA-1"/>
        <property type="gene ID" value="DME_0000582101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000582101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10163" checksum="0EF0C91359F25DAE" modified="2015-12-09" version="1">MYYHITNHFASRSFIAALSFLKNACSQSEAGKDIQVQLKSTFDCKEKRQSIVWAWSIIWLANRLTIEIHEGVAVNYCTRLHDQLTEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UER3</accession>
    <name>A0A0N4UER3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9409</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UER3"/>
    <dbReference type="STRING" id="318479.A0A0N4UER3"/>
    <dbReference type="WBParaSite" id="DME_0000588501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000588501-mRNA-1"/>
        <property type="gene ID" value="DME_0000588501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="293"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000588501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45956" checksum="37CA66A5C01105FF" modified="2015-12-09" version="1">MVGYLLSSRDVFGRKSLLWIRTEDCLILSQSITCFKKTWSEIPSGSISVINFDNYASIWHSVNFYSVREINNCLWVKQFVDLKFTWIKNKASKLLVVNRELGSTDCDIVSEMVERLCNAVRFCCSDLDSNSSLAVLFSGGVDSLLIAVITAFVIPENIIIDLINVSFDEKDYNLAPDRPHAIEAYLYLLSQFGNSRFRLILVNVDGNELVRCRQQHIAYSIAPSLSVLDDSVGCVLWFAARGSGVLYGSNDSTQVKSNAKIVLVGSGADEIFGGYLSHRSAYEKYGRLGVIDELQREMYRIGERNLGRDDRVTSGIGKDARAPFLDDRFVEWLNSLPLEAKADFTKGRGFGEKKLIRKALENFGSPQSLYNAPKRAMQFGARIAKREKRKEKANDICDRILESLNNGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF79</accession>
    <name>A0A0N4UF79_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1017</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF79"/>
    <dbReference type="STRING" id="318479.A0A0N4UF79"/>
    <dbReference type="WBParaSite" id="DME_0000607801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000607801-mRNA-1"/>
        <property type="gene ID" value="DME_0000607801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000318">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000607801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29807" checksum="8650228AE4A6DC6F" modified="2015-12-09" version="1">MLKSGSMDPTDFLSEAQIMKKFRHPKLLQLFAVCTKDEPMLIITELLHENLLHFLQVASTFYIFFFSNHIFKGRGRTCLMTQLVDIAAQIASGMAYLEEKNFIHRDLAARNILMSHALSVKIADFGLARLVREDEYEARAGARFPIKWTAPEAANFNRFTIKSDIWSFGILLTELVTYGRMPYPVYSQIFLTHSLYVENGYRMPCPPNCPPQLYEIMLQCWHKEPERRPTFETLQWKLEDLFSADPTEYKEALLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFW8</accession>
    <name>A0A0N4UFW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein Di-Ras2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9468</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UFW8"/>
    <dbReference type="WBParaSite" id="DME_0000635701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000635701-mRNA-1"/>
        <property type="gene ID" value="DME_0000635701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000635701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16986" checksum="89919898D39133EA" modified="2015-12-09" version="1">MVISCNQKNVCTLEITDTTGSHQFPAMQRLSISKGNAFLLTYSITSKQSLEELGPIILMLKEVKGDAISDVPIMLVGNKKDEEQRREVNIDVGKKLADKWGAGFIETSAKNNENIIELFQQLLAMEKKRQLVLTMNEDSSKNRIKRKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFY9</accession>
    <name>A0A0N4UFY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">snRNA-activating protein complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9492</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFY9"/>
    <dbReference type="WBParaSite" id="DME_0000638101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000638101-mRNA-1"/>
        <property type="gene ID" value="DME_0000638101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20127at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000638101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38077" checksum="5596BCDCB13CE9FF" modified="2015-12-09" version="1">MKGQGICVLPIMAGCRKDIDRLLKMYKEKETLRYKPFVEIFEKLKFHTIFMGRISSAELVEFSEKLLQLAISYAMCYQAVQPAAYTVQSQGSSHYTSATDINFNNEMTLQDRVFGIYLTYSLYFVQSDKYLAQILITPDQVNDLQEFLQDRLIPERHIDAFTALYKLISGGAFRICAFENEYNPLNCRRYDHSNLLEGLVDESQPDNCSLLRAFGEDVVLTQADLISKRYLAAKQKSKLTDKLGLNFVTSNVSQIYSLILKANEEASPNDEEEITRSRRLSGRFRSAIKEKAYKSHALTARQRRLRMRSSKTNSEANESVISAATSDSVSFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFZ2</accession>
    <name>A0A0N4UFZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9495</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFZ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFZ2"/>
    <dbReference type="WBParaSite" id="DME_0000638401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000638401-mRNA-1"/>
        <property type="gene ID" value="DME_0000638401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF5">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000638401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18814" checksum="E859ACDD57571376" modified="2016-06-08" version="2">MDSFESMCGHLNPAISVLFYTFGKIPLSYVFAYSFCQLIGAFIGTICAYLLYYDQIYHVLGVERIAVGPNATATLFTSMPPPHLSNTIAFFDQFVGTGFLALFASVVIDKRINIPAALHALLFGFVVALIGMAFGMNLGYPINPARDLAPRIFAAMIGYGIEVFTLVLSLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG25</accession>
    <name>A0A0N4UG25_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG25"/>
    <dbReference type="STRING" id="318479.A0A0N4UG25"/>
    <dbReference type="WBParaSite" id="DME_0000641901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000641901-mRNA-1"/>
        <property type="gene ID" value="DME_0000641901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="123"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000641901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26096" checksum="4DFC2FFF6C486C41" modified="2016-06-08" version="2">MITISKLKEILNSKLGPPQDIEIKINEANVIVCNWKEPEWASNYSVLRYTIYFTRDPGLTDENYKEWISVNVSSNQTNYRMSDHVLFRPKTLYRMRITASNNIGESLPSEVFEFETASHELPVPTDVQVHVNNDSSVTIFFTAVRNSINRSLYVEDYEVSISPSTDAFAAQFLSVPVTDKFFNNMNAMIALKIASKNFIPNTQYWLIVRAKIEGRRSPSSIPRLITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGC0</accession>
    <name>A0A0N4UGC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9642</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGC0"/>
    <dbReference type="STRING" id="318479.A0A0N4UGC0"/>
    <dbReference type="WBParaSite" id="DME_0000653101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000653101-mRNA-1"/>
        <property type="gene ID" value="DME_0000653101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="122"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="423"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="643"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000653101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="711" mass="79062" checksum="DBEA035AA30181A5" modified="2015-12-09" version="1">MSAESKEVQEARVPLGSDEMAMELSSTPMEVDERPAETSENIIEEQRETKTDTSVQKSGNIRPLSRMEFFTRVLNYNNENENLPHSENLQAGTSASESAPAMPPQEPIVSFYLAPNYQLKMTLHGHFKAVSSLKFSYDGLMLASASADKTVKIWNTATGDNELTISGHKLGISDIAWSIDPRYLASCSDDKTIKFCDVSNGKNVRTLRGHTNYVFCCTFHPQGNLLASGSFDETVKIWDMRNGNCIRTIPAHSDPVSAVSFNRDGILLTSCSYDGLIRVWDVPTGQCIKSLLVDNDSPPVSFVKFSPNGRYILASTLNSTIKLWDFVKSKCLKTYIGHKNDHYCIFANFSVTGGKWIVSGSEDNAMYIWNLQTKEIVQTLREHNDVTLCSDCHPTENIIASGTMDMKKQNFLQVPNYRLKYSLQGHIRTISSLKFNSDGALLASGSADKTIRIWNTADGKIEKLIPGHPLGINDIAWSIDSSYMVSCADDKNLKVWDVHNARCVRTLKGHTNYVFCCTFNPQGSLIASGSCDETVRIWDVRNGNCIRTFPAHSDPVCAVSFDCFGVLLTSGGYDGLIRIWDIPGGQCVKTLNPPATFATFSPNGRYILAAAQNSTLKLWNIFKGKSVRKYSGHKNDQYCLYSSFTYDGKWIVSGSEDNAIYIWNIHTKEIVQKLEGHSDVPLSSACHPNENIIASGTLEPDKTIRIWYSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGC7</accession>
    <name>A0A0N4UGC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9649</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGC7"/>
    <dbReference type="WBParaSite" id="DME_0000653801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000653801-mRNA-1"/>
        <property type="gene ID" value="DME_0000653801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017216at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000653801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13233" checksum="4BD66F72261EAE71" modified="2015-12-09" version="1">MILVNEQWNSWNKEQFMDVDQRIEEYGKKKAEASSETNQEVDFFIDMQPQIRKTLKAFVGNTNSIDGLRKNLFTFDEIGASIGVNDRDKKVGAELQLLTISTEIWHDHNRGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGW0</accession>
    <name>A0A0N4UGW0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related C3 botulinum toxin substrate 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1363</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGW0"/>
    <dbReference type="STRING" id="318479.A0A0N4UGW0"/>
    <dbReference type="WBParaSite" id="DME_0000674901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000674901-mRNA-1"/>
        <property type="gene ID" value="DME_0000674901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000674901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20216" checksum="63A28DD5C993632F" modified="2015-12-09" version="1">MSAPTRQIKCVVVGDGTVGKTCMLISYTTDSFPVEYVPTVFDNYSAQMTVDSHAVNLGLWDTAGQEDYDRLRPLSYPQTDVFVLCFSIVGPVSFDNVTTKWIPEIRHNCPDAPIILIGTKLDLRDDPETLRQLNSEGKQPITKSQGQKVAKKIKAVKYLECSALTQQGLKAVLISFFIILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHF4</accession>
    <name>A0A0N4UHF4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Copine-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Copine III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS1561</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2. Interacts with RACK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHF4"/>
    <dbReference type="STRING" id="318479.A0A0N4UHF4"/>
    <dbReference type="WBParaSite" id="DME_0000698201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000698201-mRNA-1"/>
        <property type="gene ID" value="DME_0000698201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000042">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000099">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="131"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN51588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000698201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38304" checksum="F6A4DCBBE24B57C8" modified="2015-12-09" version="1">MNNIDDIPCSKIRLNLSAKNLYDSDVFSKSDPMCVVYLARDAKCDGNYHEIARTETIRNCLNPEWCKPIFVDYYFEEVQRVKFEIYDIDNTSCLLSEHDYLGKAESTLAEIVGAPSSSRILPLIGPKSGRKYGEIKVIAEEADDEAKETLQLVCAARNLDKKDLFGKSDPFLQIYRINDDGTEYLLHRTEVIKKTVNPEWKLIEISMQRLSFSNQERRLRFNCYDYDNDGGHDFIGHCETNVDRLLQKKDLELFLMNEKKLRRKWKMWKKYRNSGVLIFHTVAIKREYSFLDFITRGYYFDFLSLLCIVDFNEWAQLCSIVVQFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHR9</accession>
    <name>A0A0N4UHR9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS9843</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHR9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHR9"/>
    <dbReference type="WBParaSite" id="DME_0000711301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000711301-mRNA-1"/>
        <property type="gene ID" value="DME_0000711301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="75"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="259"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000711301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48758" checksum="7451229DB4D31242" modified="2015-12-09" version="1">MSSEEIALLNKILHKKLVNLQYGPIQIHQSQSDPSSPLYSANTFESLRLKDELLKALHKMGFLMPSKIQEAALPLLLTEPPQNMIAQSQSGTGKTAAFVLTMLSRVVPGNHWPQCICLAPTFELAMQIGEVVKNMSCFMPEIKIRFAVRGEKMTRGETIVEQIIIGTPGIMLDWVLKMKVIDPSKIICMVFDEADVMISQQGHMDQSIRLHNELKHSGAKYQSLLFSATYDDSVFAFAESIIKEAVLITVRREEQTLKNIKQYYVRCANREEKCEAVINLYGGLTIASAIIFCYTRTSAEWLANRMAQRGHEVSVLHGAMSIENRAKIIQDFKDGVFKVLVTTNVCARGIDVCQVTVVINYDPPVTHFDSQPDYETYLHRIGRTGRFGKAGIAINLVSDDFSLNVIERIAEHFGKKIELLDASDMDQLEAIDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIA8</accession>
    <name>A0A0N4UIA8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9968</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIA8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIA8"/>
    <dbReference type="WBParaSite" id="DME_0000733201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000733201-mRNA-1"/>
        <property type="gene ID" value="DME_0000733201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867440at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1758" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000733201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33779" checksum="1D6CCD2D168B42CF" modified="2015-12-09" version="1">MKYSNKKLTRRDLQTILYDYVFTALFYQRFLVSHTKATNDFLRNLCVIYNKTIQINQIKWSSYHESTTQPKKIARDKRPCAFCNKDHWDNECSTYPTLQQRMEYLRKNNACLNCFRTGHATNNCNKKKRSCFHCKNPHNTALCYMKYGMQTAESKNLANVINSIAQSIHQQGQEILLLCKEIEIVNPIMPENHEKILVLFDIGSQSSFISTKLANRLRLPDGQTKDLPHIISLEQLDHGGDWKRPDILIGADYFFDFMSPYEFYKTSSGFYLLELDTLTTIVVVRLQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIJ5</accession>
    <name>A0A0N4UIJ5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="13" type="ORF">DME_LOCUS10066</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIJ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIJ5"/>
    <dbReference type="WBParaSite" id="DME_0000742801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000742801-mRNA-1"/>
        <property type="gene ID" value="DME_0000742801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000742801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16281" checksum="D46957B1F6F5E37B" modified="2015-12-09" version="1">MEFNETYFPGSVSLLDQLDKKMLVILRDGKTLIGYLRTIDQFANLVLHEALERIYFEKYYGDIDRGVFLIRGENVVLAGEIDEEKEKRADLIRLPVEEILAMQRQKAEEQAKYEEAKNRILRGRGYVSALQDIMTEEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ42</accession>
    <name>A0A0N4UJ42_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-synt_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1923</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ42"/>
    <dbReference type="WBParaSite" id="DME_0000765601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000765601-mRNA-1"/>
        <property type="gene ID" value="DME_0000765601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000765601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="12581" checksum="BAD68C12B5FE9918" modified="2015-12-09" version="1">MLPAIGPVSRVSSIPIAPTSCSRIRSSKSFFSSVPVGTAVGNTLGTSAGIAVGNPLALGTSIGIVVGESVASGTLVIRGTSLVLAFGASSVIGVSLVLSVLFATSVRSLISVVFKDSEMKRSQMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJM4</accession>
    <name>A0A0N4UJM4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10217</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJM4"/>
    <dbReference type="STRING" id="318479.A0A0N4UJM4"/>
    <dbReference type="WBParaSite" id="DME_0000786801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000786801-mRNA-1"/>
        <property type="gene ID" value="DME_0000786801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000786801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35315" checksum="8D86E031DFF20FCD" modified="2016-06-08" version="2">MIDFDPLFLGSVGFLLTALVLIVARIIKLHYDEKRAHQRTETILAMAADEDNQRRMRNAPQVIGGRRRVVTRRRFHTDDGEDRSFARQLGDQATPSDEENVPTQSLKVDEHIGKKKMAKLQAKAEKKAQREAEIANREEKKLREKEREERMKQEEEARLQEEKAEEEKKRIEKMEREKREEEEYQKMKAEFCVDEEGFDELESDLSEDLVQKFLKYIKETKVVNMDELGSHFNLKTDQAVDRLKYFMDSGELTGIVDDRGKFIYITPEELQAVAKFINQRGRVSLKELADYSNQLIRLEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJZ9</accession>
    <name>A0A0N4UJZ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJZ9"/>
    <dbReference type="WBParaSite" id="DME_0000801501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000801501-mRNA-1"/>
        <property type="gene ID" value="DME_0000801501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861610at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000801501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12791" checksum="E23A59E8AB346DC5" modified="2015-12-09" version="1">MENALVNIECEDGSVQEQRIENFYDLYDKLCQAFDIFLEHEHLENELKFWLQHRKIPYGHRVVLGARLLIIIYNGMEQLKKIAGDVNLLNSDKIEINSETEVVIIKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK20</accession>
    <name>A0A0N4UK20_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2167</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK20"/>
    <dbReference type="STRING" id="318479.A0A0N4UK20"/>
    <dbReference type="WBParaSite" id="DME_0000804201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000804201-mRNA-1"/>
        <property type="gene ID" value="DME_0000804201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF34">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000804201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47828" checksum="6BFAC6E855E37614" modified="2015-12-09" version="1">MAKLDELPQEIIWMIFNFLSSRELCLKLRLVCRFFDNLIANARYWKSRLKQLLITIHIDRQCDRAVLLKLAPLVSWRLTFVEIQIDRVTIPECRSHKSNFSPMRTSFAIETAKSLWGDGKLIVKQRNARIMSYHFATIDAIAMFETPAHKKLCISGSRDRSLALWDMSKVANGYHEEQWKVASCANAHDGWLWSVCKVPNNDDIFSCGWDNTVKHWRLTNDAVQLLTSSSEMSAILSLVCDNNIVVFGNYDGKIGVLDVRNNLEIIMNFSLHRKAVLSLAFEPGTNYIYSCSYDRTVYCMDIRMWKETNFIRLAPYIMNLSLSEGQLACATSNGDIYLMDAPQLSIYDVSLLRYFQTISCGIGRQVKINVGSLMFTSRTRRFCIYSAGSSPSLLAESEPFDAEPSSVVFLIELLKRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK45</accession>
    <name>A0A0N4UK45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2197</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK45"/>
    <dbReference type="STRING" id="318479.A0A0N4UK45"/>
    <dbReference type="WBParaSite" id="DME_0000807201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000807201-mRNA-1"/>
        <property type="gene ID" value="DME_0000807201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042864" evidence="3">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000807201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38985" checksum="9AEBC9F2E4F39D2C" modified="2015-12-09" version="1">MDEISWLLCFTLQSLWICKLALAQCPPLQTPCRCSPSVSEPVAIFCESAGSLSNVLQAIFQAQNFPIDSLHIIDTPISAIPQNAFQGFTILRLVLNRCGLSQINDGAFNGPLLDSLVEVDFTDNQLRMVPQTGLPRLRNLRKIYLNRNRIDQLQPNSFMIYESRDLIVKLELSGNRLTNQGLGDSLVFFPLRSLQQLSLETNALTAIPSASLTNQRLTLTNLNLGLNQIDQVPVGALDFPNLNSLSLEFNEITNISPEALQGIPNLQYLYLTGNKFPSWPLQMFQYINQLLTLSIGETPISVIPSNAFQHIPNLIRLEMSEAAVDTIESGAFQRTPHIQAIILNKNRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKE2</accession>
    <name>A0A0N4UKE2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS2255</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKE2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKE2"/>
    <dbReference type="WBParaSite" id="DME_0000817901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000817901-mRNA-1"/>
        <property type="gene ID" value="DME_0000817901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040022">
        <property type="term" value="P:feminization of hermaphroditic germ-line"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001922">
        <property type="entry name" value="DEAH (Asp-Glu-Ala-His) box polypeptide 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="479"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="617"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN52282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000817901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="128431" checksum="8E9D3C46B7EC24D9" modified="2016-06-08" version="2">MVGNLSNDNEDGLNRLEGSVKIAGGLEIRKKKSNDDAIFKHPGVSRFGLDVRVRMHREDSAKKRRIERESPGECFYVVEKHKGDRRGLIADSRENSKKHKPDGNSKEKGECSRSKNSQRRKNEHRSHVSKSFYEAQTPRFKVPDTPSHSAWDDDDSELKFRSSDFSWEINTPYLSRSNDGTERSISSVWRMERNREKRHNDQKRYRSDTVRSIKEEGDLIPEFRNDYERAEWEKEQQKLEREWYDNDQAYDEENNPFVQISQEYIEKKEKQWSQKHEKPRLTVRQQQIKKDNEMWENNRLARSVVKIEFFLVDNRHFLGVVTFDDQNEFLDDDKDENRVTLLVQNVVPPFLDGRFIFTKQSKPVIPVKDATSDLAVVASKGSKVVRLWRETEERKKAQEKHWELAGSNLGNIMGIKPKTEDVVSDDTSYKDSQKFATHLSSSEAVSDFALEKTMKEQREYLPVFAVRQKLLNVIRDNSVVVPRRVAAMSVAKRVSEEMGVELGQECGYAIRFEDCTSENTRIKYMTDGILLRECLGDSDLDQYSAVIMDEAHERSLNTDVLFGLLREVIARRADLKLIVTSATMDAEKFANFFGGHTPCFTIPGRTFPVDIFHSRTGLEDYVDAAVKQAVKVHLGGIEGDILIFMPGQEDIEVTCIMIKNQLEELDEAPPLAVLPIYSQLPSDLQAKIFQKAPGGIRKCIVATNIAETSLTVDGILFVIDPGYCKLKVFNPRIGMDALQVFPVSQASANQRAGRAGRTGPGQCYRLYTERQFKDEMLVATVPEIQRTNLANVILLLKSLGVEDLLKFHFMDAPPQDNMLNSMYQLWTLGALDNTGRLTKLGRKMVEFPLDPTLSKMLIVSESMECSDEVLTIVSMLSVPAIFFRPKGREDDADAKKEKFQVPESDHLSFLNVYLQWRLHKYSTKWCNDNFIHVKAMRKVREVRAQLKDIMEEQKVKLISCGTEWDIIRKCICSAYFHNAARLKGIGEYVNVRTGIPCFLHPTSALFGMGFTPDYVVYHELVMTAKEYMQCVTAVDAVWLAELGPMFYSIKETATSRMDKRLQTIREVRNMEEEMKQASSEILERQKIADQKKTSQRNIVEPGKTKLPPSVRSTRFGNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW5</accession>
    <name>A0A0N4UKW5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2407</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKW5"/>
    <dbReference type="WBParaSite" id="DME_0000840101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000840101-mRNA-1"/>
        <property type="gene ID" value="DME_0000840101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000840101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="24061" checksum="A5A2D619792304E5" modified="2015-12-09" version="1">MYRNALIFLPFLSGKYVLTHLIYIFENIKILVRINATDSKRVLDDATRKRRLLKQIDALEQDNFHEDPHAHLHWHKNIPKFDDVQVQGSLPGRRTITDHGEPAKKKRKLRTEHFKQRFRKNFMALVEEETASKTVDKSGFEAYDKTRAPPSRLPPRHFCTACGFFSKYTCITCGARYCSISCRDLHNDTRPHSVLFYYSCLKWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULD6</accession>
    <name>A0A0N4ULD6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2523</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000065">
        <property type="protein sequence ID" value="VDN52550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULD6"/>
    <dbReference type="STRING" id="318479.A0A0N4ULD6"/>
    <dbReference type="WBParaSite" id="DME_0000860801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000860801-mRNA-1"/>
        <property type="gene ID" value="DME_0000860801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000860801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15907" checksum="DC9ACD2F2BA867DF" modified="2015-12-09" version="1">MGKPKGIRTARKLKMHRQAQRWNDKRYKKAHLGTRWKANPFGAASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKIVKVANTSLIALFKGKKERPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULR0</accession>
    <name>A0A0N4ULR0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2637</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000071">
        <property type="protein sequence ID" value="VDN52664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULR0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULR0"/>
    <dbReference type="WBParaSite" id="DME_0000874601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000874601-mRNA-1"/>
        <property type="gene ID" value="DME_0000874601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9518664at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000874601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35523" checksum="D8544B3721E33CF4" modified="2015-12-09" version="1">MSATVAQTDFAINLLKSASEQTAIISPFSIGIALAMVYTGSDGRTKQQMMDILAKGATDQELHEYFSEILSNFAGETKDFTLTIANRLYVQKGFNLKDAYIEAIKEKYSSQLYPIDFKKAAEVAKEVNIFVEEKTNSKIKDLLSTDNINDDTRLLLINAVYFKGLWLKNFNPKRTLMKSFYISETKQNQVSMMHAEDEFDYTEDDDVQVLGIPYKDFKSMMYIFLPKQKFALSEMEKDVNGQWILEHINNCISTKVNVEIPKFKLEKKFELVDALCKMGMVDAFEMNADFSKISDAPLFISDVIHKVLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULS5</accession>
    <name>A0A0N4ULS5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2654</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULS5"/>
    <dbReference type="WBParaSite" id="DME_0000876301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000876301-mRNA-1"/>
        <property type="gene ID" value="DME_0000876301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5815739at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000876301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="553" mass="61109" checksum="979D923F9D56EFB9" modified="2015-12-09" version="1">MVRTFDICSCCRRESKNPLEEPYGVISHNGGSAKHQFTSVLFHDFASDLSRNAVSLSQSRSIQSNTKGKIIPLAIALPTSKKRALPELPSSISQTQNDRSTDPIYSVVFSHQKTGIVSVPFSTEAINPTYESIDAESDSQSDPIYSVLETKQKTNRRYDYPVFTSNCAGNDTVYQSASQLYTGGSEDPYSSINSNVGEKNYDLNYGHINENIPAESHSASCHSSRPSTSKNLDHLYTQIKRNPCSTANSNLTNQRFSPSPIALQNSNGSPLATTKASINQKVSREPSYRYITVRESIDIIRQRISQREEELRRILSVSGGSKSAIRDHYYSSIGGDYESVPNPNVEAPERQLLSQIGDIGLMSAKSQQDISFAPKPPTSPIPDRNKKSHILSSDDVCPYSSPFQAETYRYNRRNNTMERIRKLRSNFFNDINCGFTVSNTFHLFSAASGLVRNDMKSNEQELSTQPKKNSKEILVDLQTNKGETSTDLGRIQFSHAMRVEAVLPNAGENIVSKVANASLPSLASLYLSNSGSSQNFCAKTVKRSATLGTLNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULV8</accession>
    <name>A0A0N4ULV8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Suppressor of hairless protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2677</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULV8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULV8"/>
    <dbReference type="WBParaSite" id="DME_0000880101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000880101-mRNA-1"/>
        <property type="gene ID" value="DME_0000880101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000880101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51741" checksum="CB262E12D3D3589B" modified="2015-12-09" version="1">MVEKTFLRFFCPPPCIYLYGDGWKRKKRITEDLYRRFKECQKQNGIQESDPDTEHVNEIRSAELCAFIGIGAPSEQEKQALDFSSNKDYCAAKTLYISDADKRKYFELSVQFFYGSGQEIGIFSSQRIKVISKPSKKKQSMKNIDSKYLCIASGTKVALFNRLRSQTVSTRYLHVENGGFHASSTKWGAFTIHLSILFIILIYFFLLNKIFSVDDDPHVVDAENFNVRDGFIHYGALVKLVDSVSGIALPRLRIRKVDKQHVILDANSCEEPVSQLHKCAFQMLDSDLVYLCLSHDKIIQHQATLVDANRHQISDGASWTIISTDKAEYCFYEAMGPVRQPITPVPIVSGLELYGEGDLARVDITGSNFRANLKIWFGTTPVDTVYRSEEMIGCLVPSLSTVFPNWNTYGNEPLSVPLSLVRDDGVIYATNMTFTYKAETNRLRNRRFANPLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMQ6</accession>
    <name>A0A0N4UMQ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2883</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000087">
        <property type="protein sequence ID" value="VDN52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMQ6"/>
    <dbReference type="WBParaSite" id="DME_0000914601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000914601-mRNA-1"/>
        <property type="gene ID" value="DME_0000914601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000914601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8855" checksum="8EEA252F6A2107B0" modified="2015-12-09" version="1">MTTALNVSFRYIRMQNSSAQIYENISPKIFCDFIEAMVALTAADFPIERAAVTDKHIITKNDTVLLKTFWMYGKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNE8</accession>
    <name>A0A0N4UNE8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3132</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000107">
        <property type="protein sequence ID" value="VDN53159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNE8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNE8"/>
    <dbReference type="WBParaSite" id="DME_0000942801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000942801-mRNA-1"/>
        <property type="gene ID" value="DME_0000942801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9880600at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000489">
        <property type="entry name" value="Protein CBG01593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231834" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000942801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1334" mass="151123" checksum="E6341FC1BD1B4051" modified="2016-06-08" version="2">MEYIYKIALIFTFFFLNCGCIPNTSLCSIFDAFRIQPDNIKYEIGGAFPLHGKDCTELEASTVQDIVAIQWALTYWNQNSNNSQAKIGLYAGDSCSRVKEALFQTTRFLDSLGYLGPEECISETKRRRLSPILLGLLSPKDYESANAVASSIKSLSIPVVTYSTSSAQAFINNGINNFITTAPTLSVFIEVFLKLMKILKSDLVCIVDDGTQIQSISRLVHQIKSKKVFVSEIVSLDDPNFFDIISYSDSQIILSLINKHQLIDLLTKANALRRDKLWIAILPDSDRLSPQEQSNIVMNGIKIQAIILQQKQKEFFQFGEYFQRVIKDKYQSYFLLTAYVQKVHNCTTSRFENKIDCSKLDLNMIKSKYEQATSVEPAIRAAYGFAAVGAKLSNSKDKKICEKLSSECTKRILFELESLIYEFNSEDVEDLNEERLRFYRLNESILISSGIIIEGIELINDDFYGPIIAKARRQSRFVNNNLRVRKIRSICPPYRSFCGKCHYTVQAKPNRYFLLTPKEYPVYLMGLFDFREGHSCELIGNFDISIPMAFYYTVSTFQQKYGENDLLRNLDLGVIFADSCTVARRAVETILLGENHCFSFQQAERNITLVPGSIFGEKKSHLSAVNDVANNAIEELFTLGENVLLSFNSDRSNSIDKFTTMPSNKHQAIALVKILKKFHWEYVTVVLSEQDMTSKAAFRHFEEMATNRGICIAAVVRIIGSNIPNTVSPSATNVTLFFATALDTANFFAARFRRDSYQSRIHIVLGNGHDFYLADPSNIASFVGTLSIQPKDKIRDDFRQWIESITPLTFPEPWYWDYVENQWQCALSAANRQRYGGNMCTGVELLDIPSLGRMTRSGYLSVMLEKYLFAVDSVYKKLCPEQKGICNEFYIKGKKQILNALRKTQVEDAFDIYEFLPDIGGTFSYKNIGNWSFKNGLQFSENYQYFDFLANLHSSNKILSKTVVSLCVPPSCECRSSYKKRTEVLSDDSPSISGSYIRSQPANSVTNRDYVSLSADLGYSNRRVWNYVLLTLITITLITAISIVVLVCVKMYLRVVKGNQSLGISLLIGVIILNISAYLFIMDPSDVICRLRMVFHSIGYTVCFGVMIAKATQLKNAETLGFSTIGYISYWNYWLLLLFVIGVQIALSLRWLAQQYVLNIVLNGPQYHPVCAYSDLEFLTSQAYVDSIVVIELILCSIILLGFLFGPKLYILMSYETVVVDCETNTINGKGTLYENDLFEPVTNQDSKRNISPVSSIYNYSVGTPSPATNRPRSDDQGPVFQTVVRKKTKRRSSSEYAPRIQPLFDQQLSSATLEIKVKSHKAPDSLRPTIKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNN1</accession>
    <name>A0A0N4UNN1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3200</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNN1"/>
    <dbReference type="STRING" id="318479.A0A0N4UNN1"/>
    <dbReference type="WBParaSite" id="DME_0000951401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000951401-mRNA-1"/>
        <property type="gene ID" value="DME_0000951401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000951401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25243" checksum="9A70A9507C38047A" modified="2015-12-09" version="1">MNTDSLRKYGKEMINIVADYWENLRKFRPVSLISPGFINEMVPADPPNSPEPWEEIFSDVESIVLQKNTHWQHPNFYAYYPTGCSYHSIMADILSDGLASIGFTWKSSPPMTELELEMMNWLAKAFGIPEDFLSSQNSPGGGIIQNTASDATFIAILAARGKAVEKMKGIDANAVSIRSLTRGLLSTISHKIGSKNSKANNRTQPPYFHDPNVISLLIAYTSDQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ18</accession>
    <name>A0A0N4UQ18_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">28S ribosomal protein S18a, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3604</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000155">
        <property type="protein sequence ID" value="VDN53631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ18"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ18"/>
    <dbReference type="WBParaSite" id="DME_0001008201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001008201-mRNA-1"/>
        <property type="gene ID" value="DME_0001008201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054543at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF66">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001008201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17147" checksum="60B2F8CA4CEB7380" modified="2015-12-09" version="1">EVKEDGDVTTVEVVNFKEKSPRKVLKKILDGCSFCTCNAPVKISYEDILILEQFMREDGTILPRQITGLCKQQQFRIERCIMQAHWSGLFPDKTLPDFDRAGYKRFNRYWNGDMDMYRLKEKVEQGSWYYIKRYKIVNGSNHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQA5</accession>
    <name>A0A0N4UQA5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3692</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000169">
        <property type="protein sequence ID" value="VDN53719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQA5"/>
    <dbReference type="STRING" id="318479.A0A0N4UQA5"/>
    <dbReference type="WBParaSite" id="DME_0001018201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018201-mRNA-1"/>
        <property type="gene ID" value="DME_0001018201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18213at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF0">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20349" checksum="04E3048C2FC64C79" modified="2015-12-09" version="1">MEQISRIEENWKIREDVQIPPFRNFDEFLLGKARFELPPFRDLTKWNNRIMSNLLYFQTNYIVITLVLVIISSTLNARDMCIGLLSICIFALRRQNTLITFGAVIISLYIFIRSFSSVITVVFIFAIPVFAILVHASIRLRNVKAKLNHQLERIGLKTTLMAQLLEAFSIDIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR71</accession>
    <name>A0A0N4UR71_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3977</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000236">
        <property type="protein sequence ID" value="VDN54004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR71"/>
    <dbReference type="WBParaSite" id="DME_0001054301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001054301-mRNA-1"/>
        <property type="gene ID" value="DME_0001054301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="122"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001054301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26821" checksum="2711F61A277E77CE" modified="2015-12-09" version="1">MSGGIFQSPNYPIIFSDEKCFIYQFIAPTNYIVQTIFSFFNLSPRRNDRIYDQTMEGRIDEATPYSHELCGVEIAAGTAFYSLTSYLVFHLRLSHGIKGFHGTYKFVAKGKFRMNATEVQPCRYSMDFLEGSIFSPQYPYSYPSLVNCSYYFPNRNSMKLVLSLDYLDLNTDSCRADFIDIYQMQPKVSKKIPFQIHLDRLCYDSIPPYSISSRNGLILQFHSGINDKKQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH4</accession>
    <name>A0A0N4URH4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4071</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000270">
        <property type="protein sequence ID" value="VDN54098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH4"/>
    <dbReference type="STRING" id="318479.A0A0N4URH4"/>
    <dbReference type="WBParaSite" id="DME_0001065501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001065501-mRNA-1"/>
        <property type="gene ID" value="DME_0001065501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001065501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11060" checksum="8C130744031F7152" modified="2015-12-09" version="1">MPPSRVGKSRGFEQVGLYHLINNGAVKRSILFLPVYPFMSDLEPVENLWKTSRNIYNYIFVSRRGYSKRVLRDDASQFQLVFKTIMKTITKAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URN3</accession>
    <name>A0A0N4URN3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4121</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000308">
        <property type="protein sequence ID" value="VDN54148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URN3"/>
    <dbReference type="STRING" id="318479.A0A0N4URN3"/>
    <dbReference type="WBParaSite" id="DME_0001071501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001071501-mRNA-1"/>
        <property type="gene ID" value="DME_0001071501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001071501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="47852" checksum="AF0D115FD31006DE" modified="2015-12-09" version="1">MSSSGVDEAQLELPSSGGEANYASNSDSGVTRRSFGRFHLAKLYWSANSVASSGDMSLFNAFDWPSVDGVSAGRAVTVGALCRIICSKTSYESLPDSQLAQFYKVLYESLLEKDRLILCSLIYYGSNIFRLDLRGVEVLLPVLVDAIDIILTESSKLRLHPSISGIEMRRACLNMLSSIICWPTTFNSTRIAGLKISKKLLQQVIVSENCCVSFIRSVVSSICDNLCKPHWSSDLSVCLAAIDCLNALSSISHCLLFYKRDLSTGFLIVTSLCRFINNQLMKPPPLHSRDLHSSVVAAFSSLAVWLCAAPLLAETESCLTTITETIELGTTGGKNLVRTPMEERKAASIRVNDAAENLLHVLFTAVVNFLPLNFIYKLNANLGHIDSLGDSSSNNSHHSIVVVCYLSQELEAELFCSSFLVLFLFVIPEGIFVESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URQ4</accession>
    <name>A0A0N4URQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4139</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000321">
        <property type="protein sequence ID" value="VDN54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URQ4"/>
    <dbReference type="WBParaSite" id="DME_0001073601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001073601-mRNA-1"/>
        <property type="gene ID" value="DME_0001073601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001073601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7992" checksum="2B2115EF090E5481" modified="2015-12-09" version="1">MRNKCQPPYRMLARQLCPRMCATCCFTKEYNCENASPTQNCKDERQGCEAIRALNSCGGVFRTTMMQQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URW1</accession>
    <name>A0A0N4URW1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4194</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000388">
        <property type="protein sequence ID" value="VDN54221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URW1"/>
    <dbReference type="WBParaSite" id="DME_0001079301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001079301-mRNA-1"/>
        <property type="gene ID" value="DME_0001079301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001079301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35183" checksum="FC6825151DCD3A92" modified="2015-12-09" version="1">MDEVAGPQDEPIVPRKIEKPGYEETLSKRPEEDPANYAETTPPTDKVTESQDKLIMPAKTEKFGDNETPSEQPEQEPANDAETELPAEVTETFAGSQNEPIVPWNIEKPGYVETPNKRPEGGPANYAETAPPTDKVMESQDKLIMPAETEKFGDNETPSEQPEQEPANDAETELPAEVTETFAGSQNEPIVPWNIEKPGCEETPSKRPEEGPANYAPLTDEVTEFQDEPIMQEKKPDEQETPGEEIVNKGKIDVSTEPILSKFFSSSCPESKITLANRDNILKKLNELRKKVAAGKFSTSDGTYPVAKEMYKLVIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2H6</accession>
    <name>A0A158Q2H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4423</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2H6"/>
    <dbReference type="STRING" id="318479.A0A158Q2H6"/>
    <dbReference type="WBParaSite" id="DME_0000006301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000006301-mRNA-1"/>
        <property type="gene ID" value="DME_0000006301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10046198at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057448">
        <property type="entry name" value="BCL-11A_Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25491">
        <property type="entry name" value="CCHC_BCL-11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCL-11A-like CCHC zinc finger" evidence="2">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000006301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17416" checksum="1045680276C97C47" modified="2016-06-08" version="1">MTSSDSGIDSCIEVDTEVKDGRDERDEVAASPSDSSSDDVVAATQTSTHRNNDIILCGQCNSEFPLASLPNFIEHKISHCKVGSSSGLLDTTSSSSNLHHSYAFQSFRQQKSPSLYNRISQDASSSRCLQSTSGNQKNLLLMENCQIFKIDATTDTADLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q368</accession>
    <name>A0A158Q368_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6143</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q368"/>
    <dbReference type="STRING" id="318479.A0A158Q368"/>
    <dbReference type="WBParaSite" id="DME_0000178301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000178301-mRNA-1"/>
        <property type="gene ID" value="DME_0000178301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6337587at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="13">
        <location>
            <begin position="76"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="294"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="12">
        <location>
            <begin position="569"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000178301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="669" mass="77730" checksum="A62E63A9996B3875" modified="2016-06-08" version="1">MLLDLPIKSKMITVRYRNNQLTSKRCHLFVITIFFGLTLFFTFLLLRLAFRRTATPLSNIPPEGNQYFRLPTTLQPFRYKLQIKAYLPYRQIYDFGTKNFTIEGAVRIDFTCLKNDNKIILNAKELQLRLADVRVSNHRNEEIRVLSGKQYIQERDDIHIIEFILDETFESGYNYSIDITYTGIIGDSWAGGLYKTNYETDSETRSLAITQLQPTDAARLLPCFDEPEMKAEFIISVIHPTNTSALSNAAINRIKTIDMLWKETYFEPTPFMSTYLLAVIRVWAQPQKIETVNFALHISCRILAYYEEYFAIPYPLKKLDIVAVPELRVLAMENWGLITIRQRLILYDERMNSYRDKRFVIDVLAHEIAHMWFGNLVTMRWWNDLWLNEGFASMMSPKAADFVENSTLRSSQYFAAEVLVKALAADEHTTTTQAISLKKGSDRGAAVLRMVESAIGQDVFQQGLRQYLKKFAYGNAEKDDFLRSFSQECKMIKDGGEQYPTNFSVFDFINSWIYQRGVPIIHVGNNNKAYENSLWKIPIFIGSGSSRRVVWLSEWNNVTIDNEKKPLVLDNDFHGYYRINYDIDTWYEIIDQLLLDHNVLPPASRLKLLDDAFVLAENGNIPYAIPLKMSTYLKNEDEVVPLMIFFARSDVILYRIFRHPNSSLLNIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3N6</accession>
    <name>A0A158Q3N6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Protein kinase C</fullName>
            <ecNumber evidence="2 15">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS7124</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 15"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3N6"/>
    <dbReference type="STRING" id="318479.A0A158Q3N6"/>
    <dbReference type="WBParaSite" id="DME_0000276401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000276401-mRNA-1"/>
        <property type="gene ID" value="DME_0000276401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20834">
        <property type="entry name" value="C1_nPKC_theta-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20837">
        <property type="entry name" value="C1_nPKC_theta-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001541">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000008">
        <property type="entry name" value="Protein kinase C theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000020">
        <property type="entry name" value="Protein kinase C, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000551">
        <property type="entry name" value="PKC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="261"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="521"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="267"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN57151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="DME_0000276401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="591" mass="67581" checksum="AD3C40E99B79B441" modified="2016-06-08" version="1">MNFFLAAKDRPMDNGTPRSFDENGLQRRRGAIKHARVHEIRGHHFVATFFRQPTFCSLCSDFMWGLNKQGYQCQLCSAAVHKRCHEKMLSQCPGSAKNTKETIYLKERFKIDVPHRFKSYNYKSPTFCDQCGSLLYGLFKQGLKCEVCGVSCHHRCQKYMPNLCGVNQKQLSEALFEIKRGTHSQMSATGVMSVGPHVTIDGRSASSPANCSTPTASKFPEKVKAFFRNHNYTLENSDNEEFISAPWSAADGVKKYSRQNFIFHKVLGKGSFGKVLLVELKNRGEFYAMKCLKKDVILEDDDTECTFIERRVLILSSECPFLCQLFCSFQTAEYLFFVMEYLNGGDLMHHIQQVKKFDEERTRFYACEIIIALQFLHSRDIIYRDLKLDNVLLDSEGHIHLADFGMCKTEMNRENGMASTFCGTPDYIAPEIIKGQLYNEAVDFWSFGVLVYEMLIGQSPFHGEGEDELFDSILNERPYFPKTIGKEAAKCLSALFDRNPNTRLGMPECPDGPIRTHSFFRGVDWKRYEARQMIPPFKPSVKSPADASNFDEDFTQEKPQLTPIADKTLLASIDPEAFLNFSYTNPQFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3P3</accession>
    <name>A0A158Q3P3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS52</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3P3"/>
    <dbReference type="STRING" id="318479.A0A158Q3P3"/>
    <dbReference type="WBParaSite" id="DME_0000282301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000282301-mRNA-1"/>
        <property type="gene ID" value="DME_0000282301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000070">
        <property type="entry name" value="Putative carboxypeptidase suro-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF54">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="148"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="13">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000282301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61928" checksum="67EBDE17C393221A" modified="2016-06-08" version="1">MGIQVSSQYQYPDFWTGLLLQGIGLQHSALSNNPLSHSVTRSFVVAPLIYKINFTTRPMLDFWKTPKRVGEFADVMSGPMATQPLIELLIRNNMKHIITISDVEKLIIERESRENDNAQLSMNNPLESFIRRLKDYSSSNRAKLSLNEYHSYNEISQWLEDIQFHYPRIAAIFTIGITHEGRPIKGIKIGYPIHATNKRIIWIDGGVHAREWAAIQTALYFIDQLVSKYGSDPQITAYIDALNFYIIPVVNPDGFEYSRSDIVPPVCKKDRWKRERCCGGVDLNRNFDFHWGESGSSTDICSDIYQGSTAFSESETRAIRDKMFSPELYGKVDAFITLHTYSQMWLHPYSHQKHTFPDDVEDLKSVAKRGIRTLESLYGTKYRLGTGADILYPSAGGSDDWAKAKAKVKYVYLLELRPGEDEWDGFLLDRKQLIPTGRETWEGVKVVIDTVLKQHGARLKNATKTLLQKFPSQWQYAETLSNIFNKFEFFKTVQFLDSGATCRDASPWCHNWIRSSPNICKTSIIYMRQDCFKSCDYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4E4</accession>
    <name>A0A158Q4E4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8543</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4E4"/>
    <dbReference type="STRING" id="318479.A0A158Q4E4"/>
    <dbReference type="WBParaSite" id="DME_0000466001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000466001-mRNA-1"/>
        <property type="gene ID" value="DME_0000466001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01083">
        <property type="entry name" value="DNA_PHOTOLYASES_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000466001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49325" checksum="1E50794A939EC381" modified="2016-06-08" version="1">MATNSKRIHQLNKQMIFNGGKYILYIMRCIRQKSSPALTFSCKRANLLNVPVISAFFYDYQNHNKAQRVFLMEGLIEVKKKMNSSGIPLICLKANNKTAVQIAADLSKWACEVVIDAGYLRHERLFEENLNNVLVDGNRRLTRVEGNVVVPVTLASSLLEFGARTLRPKIWQHVADMLKEKWNDQPIVQCKDLKSVVDVKLDYMDLSVELKEALEQRNSKNKFIGGENEASKTLDDFISKKINGYETKRNIPGTDYQSSLSPYLHYGMINPVDIIRRVNESKVNKASKDAFIEELLVRRELSHNFVYYAMDNYDKMHGYLRMYWAKKVIEWTPSYQHALDFLIEQNDKYELDGNDPNGYAGVFWNFGLHDRAHAERKIFGKLRYMNAEGLRRKYKNNIEKFVEINYRLANRQLDEPLPKKSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4I4</accession>
    <name>A0A158Q4I4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS548</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4I4"/>
    <dbReference type="STRING" id="318479.A0A158Q4I4"/>
    <dbReference type="WBParaSite" id="DME_0000492701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000492701-mRNA-1"/>
        <property type="gene ID" value="DME_0000492701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF10">
        <property type="entry name" value="ULTRAVIOLET-B RECEPTOR UVR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="154"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="378"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000492701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49232" checksum="7655C01461B7079D" modified="2016-06-08" version="1">MLSILSDQILDNIRANFILFQSAIIFGSSGNEAIFLTKDKELFAIGANNSSCLGTNQSQATLEPMKIEALSGKEIISFAFGSGPHVLALTRTGEIKSESRYMKYFKKNYCNLFSGIGSTIVGTTPLLVGESLSGEKIVNIACGNHHSVAVSDKGDIFTWGRNSHGQLGIGNNINQEIPSKVGGQLVNRFVKAASCGQNNTMVLTGAGEVFSWGFNGNGQLGIGNLSNQSSPSLVVGLNNVFISQIASGFAHSLALSDEGQLFAWGSNSCGQLCAKLPHSNQTTPVVIASGLGRIVEIAAIHPCNIAVAVNQNGKVYMWGQIRGQTVLTPIQTYFHSVDDVFACFANPPVTCRPLRFDKEHQSSILDAIKMAFDDPSTSDLQISIDGHIIHAHKALLRMRCDYFRSRFQEHWKDESDSCIHHMTAITQTEAFAHMEDAIIKQFIIEVARNGAFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4L2</accession>
    <name>A0A158Q4L2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8949</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4L2"/>
    <dbReference type="STRING" id="318479.A0A158Q4L2"/>
    <dbReference type="WBParaSite" id="DME_0000515001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000515001-mRNA-1"/>
        <property type="gene ID" value="DME_0000515001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000152">
        <property type="entry name" value="Protein CBG00336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="201"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="423"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000515001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="679" mass="77279" checksum="4626CBB0306727D7" modified="2016-06-08" version="1">MKRRSLAPSVSPTSRGARIVVRSIDIDEIDAQQKRKKTTVGGSLMFRGTRHTRKFRTGVCHLITLFETRPLRDNSDRLINPYRIMCLDSLADLMIKERDKHEELIQKLLSRPFRVPVPGYISSGTAPALGLRHSTIRCALHDPYAEGALVLFTPPSMNAHDALKIEENKKQVHVVVDPAITCVLRPHQREGVKFLYDCVTGNRIEQAYGSIMADEMGLGKTLQCITLIWTLLRQGPEATPTINKAIIVCPSSLVKNWDKEIIKWLGGRLNSLAVDSGKKEEIDKNLESFVAQTGIRCPTPVLIISYETFRLHALILQAKEIGLVICDEVKYELIICCQLTDVQEKLYKRIVSSIKIKQDSKDEGRMTGAALSYITNLKKLCNHPQLIYEKCLNKEEGFQDCIGLFPSGFNAKSFEPAFSGKMKVLDYLLAIAKKTTKDKFVLVSNYTQTIDSFVELCKMRNYSYVRLDGSNSIKQRAKIVEKFNDPESPEYVFLLSSKAGGCGLNLIGANRLVMFDPDWNPANDDQAMARIWRDGQKKHCFIYRLLAVSCVTWGFWGFKMVRRYNDKEILASRRVQKDLRGAGTIEEKIFQRQTHKKALSSCVVDEEMDVARHFSKEQLRHLFELKTDVASDTHDSLKCKRCINGLEYREPRESADTNSDLSEWFHAQRDMRKVPDQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5H1</accession>
    <name>A0A158Q5H1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9995</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5H1"/>
    <dbReference type="WBParaSite" id="DME_0000735901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000735901-mRNA-1"/>
        <property type="gene ID" value="DME_0000735901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020956at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190:SF1">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000735901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27856" checksum="9C282C69942B242E" modified="2016-06-08" version="1">MIIYGDNDIYKIQSVLRTFFTPALQETVNFCLQRSPKVFNIEAYCDICQKEFCNKYYLQTHRKAKHELNLSAFSAFMSSKAETAFRQGSPMIGTDFVMNGQMINPEMQFFTGISPQLFSPNVDQRTANQPTSTDLQELMMYCIDPVTIKNFYETRLAATNNMTNISSVSENINKANPVHDLIDPQPSNHFSANESQNDETQAQARSSNGQAAERIGIPTSDLATTTTTMTATVIHAENIDSDSVLSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5T9</accession>
    <name>A0A158Q5T9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATOR2 complex protein WDR24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2304</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR24 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5T9"/>
    <dbReference type="STRING" id="318479.A0A158Q5T9"/>
    <dbReference type="WBParaSite" id="DME_0000827401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000827401-mRNA-1"/>
        <property type="gene ID" value="DME_0000827401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000827401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="743" mass="85200" checksum="B76D5A342A3DE4C9" modified="2016-06-08" version="1">MNQLFCRLSRASEIYKIIIPRQQSIFNSNVFRHGRLKMRIVLLRRQLRADWWHCGILKRLQHLYKTHSRSVSKVCFHQSDKNLLISGLKDGCVVLYDLRLPKFTAKFISKFSSDPVRDVQFGLHTGQTDVFVVADDGGSMHFWDLRRSDRPLREFVAHHGPASIALNPSYEDRNVLATAGRDKFIRVWKWCDWHESNQSSAIYSVETTTSVSRVRWRPLQKFHVTSCSFVNDTNIHIWDIRRPFLPIGSFDIHRELCCDLMWKPDDSNVLISAVKNGFIGLHFFENADRPLNHVNDVAIDISPSGEIAIALSSHLKQKIEALDDIKKIQRGEAVPRRRRVYEPFQSWIPSHLVICGSKGSSASLYPNHFIQFANGEQMKASKDFLFSYQLCGSDLQKLCMHNAFIAKAVSRRRLACTWRMIGLLCSLSPFFEVNDYKIQSDNRRSSNEDDEDASSVARSRFSSNKSSGGIHNIESEDFNNFSTVSPELAGTADFFFGEGEVNMDRLDFKNSEMNSPRNYTGSAFLKMEAFTPRLRDEFDLFDEIRSNSTEDGSTIADDCSNELGERSFFLGKLSIKNDVVSLPMWDPLPVIRSLFEYYSDLGDVQTCVSMLLVLGKRTAEFIDIALQKLWFLDYIGMLERFELWTVSAEIIKLCWIPSVNNLSNENTFVRLLCTNCQTPSFSTFSQCKKCDAKFQFICSVCCQPVCGLWMWCRGCRHGGHPNHFSEWFSTNELCATGCGHRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6E3</accession>
    <name>A0A158Q6E3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10778</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="UYYG01001246">
        <property type="protein sequence ID" value="VDN60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6E3"/>
    <dbReference type="STRING" id="318479.A0A158Q6E3"/>
    <dbReference type="WBParaSite" id="DME_0000985701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000985701-mRNA-1"/>
        <property type="gene ID" value="DME_0000985701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000007">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000985701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="76331" checksum="957F66029C400834" modified="2016-06-08" version="1">MGLLTKGTPLSWKEIIPYVDYIKEHGIKQFITLYHRLKDREGDQLRWGDEIEYTIIAFDHEAKKACFISYSFGKFLISLLIINFVRVSLRAEELLNRLSAAEEVNALIGVENCHLWRPEFAAYMVEGTPGVPYGALLACFNSVESNMISRRAEIMRLLKENEAVMSISFPALGTPDFTVPPTRPHPEDEKAAGRSLFFPDEAIYLGHPRFRNLVRNIRERRGEKVAINIPIFRDKNTPSPYIEEIEADAAKPDHIYMDHMGFGMGCCCLQVTFQAVNVREARWLYDQLTPITPVLLALSASTPVFRSRLADVDSRWDVISASVDDRTAEERGLVPLKQNKFVLNKSRYDTTDCYICPCSMEYNDIPLEYDPKIYQQLIEGGIDEPLSAHIAHMFIRDPLQVFKERIEQDDSASTEHFETIQSSNWMNMRFKPPPPFAPEIGWRVEFRPTEVQLTDFENAAYCCFVVLLTRVIISFHLTFLLPISAVSDNMKRAQRRNAVMNQKFLFRKCSPICGKSCDTTDNSSSDDIVEMSINEIINGKDSEFPGLVPLIRNYLDSADVDVDTRCSISQYLSFIQKRASGELLTLASWMREYIDKHPNYKHDSILSDHVIYDMLKTMNEIANGELRCTKLLGNYENRSKTNHGIPKAVRRAEERLVLSRIEHKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6J5</accession>
    <name>A0A158Q6J5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10864</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001261">
        <property type="protein sequence ID" value="VDN60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6J5"/>
    <dbReference type="STRING" id="318479.A0A158Q6J5"/>
    <dbReference type="WBParaSite" id="DME_0001027401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001027401-mRNA-1"/>
        <property type="gene ID" value="DME_0001027401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="197"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="360"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="482"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="616"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001027401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="887" mass="102261" checksum="30D862010EF43726" modified="2016-06-08" version="1">MEQSFWIKLRYSADNDNDSDDFGRNLIKPRVHLKFSKTFGGIVTSPKVASPSAYDWKLIGYRPLEWILSGDINYWLKISIKSIEIPDEREKNLDDDERESLKGLIVQDFSFNICYSSCTLNQRSQLCGSIIASHAGYNAPKDFVTDFIIKTHIATVLFSAPAGSSFSLTWKQLLVHQAKVEISSNNISQSDASQFTCGEQLQPTYQAKYLKVPAENESDELFDIAQSFANMVSWRDMRRYRYKSGYANNLKCRWSIVRPKFTGISLKVISLDLEEHINCNYDYIAYSIGDIDFKDGQIRYLCEEYFQHLYFADGNYIKLCKHKDIGFEETYRNGEIIYIYFITDRNRSGKGFVIEYKLACLSFDYIFTSMGILDEIVHSPNYPDKYPANLTCNWSIVLESNRAILAKFVDMDIEEAVSCAKDSITLQEGYMAVDDPNKRLCGKQSDWNETFTSGRVFISFITDASVNKKGFALRLMEQIHDCSSDRLTINEGDWPKVLHSPNFPKLSPNSLDCQWVINAPVGHRIQFSVDPLTFDLQDTSGNNSYALFSKHLYRCIDDYLEVRDGPSKNSPLFGIYCRREPPSTIFSSGSYLYIRYRTDSYIESTGFNSTYEIATCGGTVVLATNKTSFIRSPNFPDPYPSKVECTCFAHLWLTYKENCSADSITMREHNATGEYILKPTCASITVIGKFFQTRRNIMSVFFQSQNNQARSSRMFCLQRKCGFEIVFKPSQIDHLMPQIACDWKFKAGIGYRYVLDFSFTKHQNFYQTAFDQTGCYPDVVVRNGVHDLPYFYGLNRHNFCENKTRFISSADVLSLTYDDRMTHFAKRELFTSNRNSERIYAPFRIEYLKVPQDYDSNSCMYHITTNLTIIINETDNLEYSIRFNPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNA7</accession>
    <name>A0A3P7PNA7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS1736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNA7"/>
    <dbReference type="STRING" id="318479.A0A3P7PNA7"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN51763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="127" mass="14823" checksum="60EE5B61C2E91E3D" modified="2019-02-13" version="1">MINSGYQFSSNDALRNVTRKEFGAMFEFIVQQLDPNYKLNGKLEEIPKFFHDFGYPVVIKLSTMQTIGAAHTMPHLYGALSWLIDAIEENLEMLKREMEDQKLDLEKLQNLNDHLNENCQQLQMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PR68</accession>
    <name>A0A3P7PR68_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000091">
        <property type="protein sequence ID" value="VDN52973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PR68"/>
    <dbReference type="STRING" id="318479.A0A3P7PR68"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="412" mass="47882" checksum="39F68D6A9D7EA52B" modified="2019-02-13" version="1">MNLLNYGLQILNFWMEIFNNKYWKLQQKIRLNGPITVADYMRMTISLPMSGYYQQFSNNHEIFGHKGDFITAPEISQLFGEMIGVWCYYEVGNAGHKGEWQLVECGPGTGQFMNDISRTLDRFKEKKFSIHLVEISDSLIKKQENILCNSITNYIEGHPYIKSNITKYGIPIFWYRSVDEIPTKFSVFIANEFLDALPIHQFQKDDVGQWHEIYIALNENDQLYFMLSKGENLYTKGLIPEKVRRDHKRTVWELCPDACLFVSQIAERITQYGGIGLLIDYGHDGQRSTLSLRAYKNHQLVNPLKNPGKQDITADIDFGYLRSLIEEQTQGLREFLTHMGIGIRLNRLLQSCSNEKDRENLVESYKFLMSDEGMGSRFKVMSIYPKVLYETLIFRQGPAGFPQDYSRNILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PY39</accession>
    <name>A0A3P7PY39_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PY39"/>
    <dbReference type="STRING" id="318479.A0A3P7PY39"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="548" mass="62031" checksum="911BE69CE87790AD" modified="2019-02-13" version="1">MYFYSVLIFFIIYEFRYVKGYTVKKIRHLGDTVYFSLATSSEAHEVIKLLNGFNIKGRIITAKIAPYDVKLSLNKNPSKIRSAKEIVTPLGDCEYDKQLELKMQAVSRVVKKLIKELDKANIAEARKLSVSKLVEPIRPSPVVKCYRNKCEFTVGRTINKDICVGFVGGRFALNEHHVIPIDTCDNISSHMKRIVKTFEEFIIGTGEPPFDESERKGCWRMLTVREFAGDVMLIVTVYPLEDLEKEILLKNLFIAQFLRPENFIEPTRKFRVTSLYWQRLINASDAAQYEHIGGTPYIYETILNIQFRVSPAAFFQTNSSCAAVLYSLIVEKCGFINSDILAKYVVSEEELCSENDAMKQPDEKKRKIVSTLKSDQALFNTLLLDICCGTGTIGICVLKLLKCRGKRYLIGIECVHDAVEDARSNAIANGFDGDEFQFITGKAEVILPNIKQYIPASFNLSSSKVIGILDPPRAGVPVKVIQGCRKLSDLCRLIYVSCNPSLVKKNLVDLCRPTSKKYEGKPFCIKSITPVDMFPKTSHCECVIYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PZS4</accession>
    <name>A0A3P7PZS4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PZS4"/>
    <dbReference type="STRING" id="318479.A0A3P7PZS4"/>
    <dbReference type="OrthoDB" id="5864185at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF88">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="151" mass="17329" checksum="76C51791A4082366" modified="2019-02-13" version="1">MQADLLIAVKVANDFKTEAQQEILKLSDKINELQKRRHSSRRNALLHWAKKIIANQYSQLDVTNFSSDWADGRALCFLFSAFFPKKIDIIGNLNAEKCVELALKTGQEVGVSVNLSVPDFVREDRPDWTIIMKYILNVYYIVSDLGKYTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0N2</accession>
    <name>A0A3P7Q0N2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Granulins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0N2"/>
    <dbReference type="STRING" id="318479.A0A3P7Q0N2"/>
    <dbReference type="OrthoDB" id="5854875at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00799">
        <property type="entry name" value="GRANULINS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="235" mass="26067" checksum="540AB06E6A832D6D" modified="2019-02-13" version="1">MVFHLFVVLSSFSLIYVIFRSSLRIVIILSIMIHNDKNDKISVIKIYQSHKYYGFLLRLLCMNNVVLVLIFSIEGILCPDHEKSCPETATCCLLEKGIYGCCPMKNAVCCEDHKHCCPENSKCDVEHGRCINSDGSYEEMKKQRWRDLNNIVCPDKTSVCPDYATCCELSGGEYGCCPAQHAVCCSDKLHCCPEGMVCASGGRECVHQEVKSTCCPFRDGICCLGGVNCCPAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QL55</accession>
    <name>A0A3P7QL55_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QL55"/>
    <dbReference type="STRING" id="318479.A0A3P7QL55"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="426" mass="47692" checksum="19D4618D5CDFEF79" modified="2019-02-13" version="1">MASGDEPLPFTFRTHDGLQIQQSISHSLFNLELIYYPEAIFQIRPVTRCTSSIPGHGEPVVSIQFSPDSRNLASGSGDKTVRLWDLTTELPLHTCVGHSSWVLCLGWAPDGKKLASSCKSGEIIIWNPLTGKQIGHKLTGHKQWINQLVWEPYHINPNSRHLASAGKDSVIRIWDTFRCTLLRCLTGHTQSVTCLAWGGLGLIYSGSQDRTIKVWRFKDGVLCRTLSGHAHWVNTLALNVEYVLRTSCFDPKSDSRCCPTEKENQKLAYDRYEKVKNLSGGEILASGSDDFTLYLWHPANEKKPIARMTGHMQAINQVMFSPDARFIASASFDKSIKLWCGRTGKFIDSLRGHVQAVYRIAWSSDSRLLVSGSADSTLKVCRFHLYSPLCEDLPGHSDQVYAVDWSPNGERVASGGKDKVVKMWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SBY0</accession>
    <name>A0A3P7SBY0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Skp1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SBY0"/>
    <dbReference type="STRING" id="318479.A0A3P7SBY0"/>
    <dbReference type="OrthoDB" id="5786141at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="135" mass="15588" checksum="317684132C1232E7" modified="2019-02-13" version="1">MGMDNDDVDQNILSADPIPLDTISGSILRKVIQWCQYHKDDPETPEEMDSKEKRTDDIPPWDVEFLKVDQGTLFELILAANFLDIKGLLDVTCKTVANMIKGKSPEEIRRTFNIKNDFTPEEEEQIRKENAWCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SF62</accession>
    <name>A0A3P7SF62_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Growth hormone-inducible transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000087">
        <property type="protein sequence ID" value="VDN52912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SF62"/>
    <dbReference type="STRING" id="318479.A0A3P7SF62"/>
    <dbReference type="OrthoDB" id="6285520at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32962" checksum="9645053E646AE4E2" modified="2019-02-13" version="1">MFNVERSSINTKIGQTLRERLLGPTTGKPFVYGTYALAGASAFGIGLMCYYGLYGSQLDSAAFNMTIWPEYVRSRLQLTYGYFGSSLLATATSAVMASRSPTIMNLMSTGRVFLLTMAAIVGSGMITRAINYDNTLMKHIAWLFHAGIMGAMLAPLCILGGPALIRAAWYTAGLTGGLSLIAFSAPSEKFLKMYGPLAMGLGIVFVANIGTFFFPPGTALGASLASIVVYGGLILFSAFLLHDTQRVVKLAESYPVVLKNQFNYDYEIMRRFDPINAQMSIYLDVLNIFIRMAMIIGGGGARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SN31</accession>
    <name>A0A3P7SN31_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SN31"/>
    <dbReference type="STRING" id="318479.A0A3P7SN31"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="163" mass="17535" checksum="6057E0F438B8EC7B" modified="2019-02-13" version="1">MSKLREICAELDEKPITIAPGAVVCKEASLHGTITIGSGTIVHPTAVIRATNGPIVIGENNNVEETAVIENLCANGETLYIGRDNVFEIESVMQASRVGDNNIFGVRSRVGPNTIVTNGCFIGTKCSAVMTETLPENMVIYGETNIRRIASDPPQVLFSYLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Q1</accession>
    <name>A0A0N4U0Q1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1</fullName>
            <ecNumber evidence="5">3.1.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Metazoan SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Penta-phosphate guanosine-3'-pyrophosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4498</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">ppGpp hydrolyzing enzyme involved in starvation response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>guanosine 3',5'-bis(diphosphate) + H2O = GDP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:77828"/>
            <dbReference type="EC" id="3.1.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MESH1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.7.2" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Q1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0Q1"/>
    <dbReference type="WBParaSite" id="DME_0000013801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000013801-mRNA-1"/>
        <property type="gene ID" value="DME_0000013801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430679at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000012">
        <property type="entry name" value="HD domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000013801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28184" checksum="F1BDEA830FFE17F2" modified="2015-12-09" version="1">MSGSGKMSGKNGDLPDKPPSYADICFEKGKHAKIYPGMPEDRSDENGKFKENEPEKNELKYNCATNDISLFIKAVDFAARRHRNQRRKDPAQTPYINHPIGVANILINEAKITDITILICAVLHDLIEDTKTTLEEIKEQFGDEVRSVKKILPVASIVKECTLDKSLSNSQRKSAQVQRALNMSHKAKLVEMADKLYNLRDIARVKPVGWTDHYKIEYFKWAKEVIANMKGSNELLEVALDDIINSNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Z9</accession>
    <name>A0A0N4U0Z9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3847 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4609</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Z9"/>
    <dbReference type="WBParaSite" id="DME_0000024901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000024901-mRNA-1"/>
        <property type="gene ID" value="DME_0000024901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000024901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11371" checksum="593B10580089ECD2" modified="2015-12-09" version="1">MESLPVTSVLPDMIAELENKAITMREMLAELEKQDYKTILREKEILEKKCQFLRTEQMKRKRIAERMLDTILENCPYDKKKLMVQFQTTGTFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U199</accession>
    <name>A0A0N4U199_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TESPA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4727</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U199"/>
    <dbReference type="WBParaSite" id="DME_0000036701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000036701-mRNA-1"/>
        <property type="gene ID" value="DME_0000036701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000036701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34435" checksum="F8394D532A6F5B8B" modified="2015-12-09" version="1">MQPEDESLDESFEAVAKANISWHFSPSSLCNEHGNQADISKRRTNFEEEWLENCKDIEDKIQEGQEFSLLSYTRTPSPLVDHRGLCSMAETSAEELWMDIETEKEKAECDKALKEGEDACVQLLQMLPVRHDSIKSVSKRPDFWSDDSLICDGLNDTMRSQFEPYQKIPVSPAEFNKSFKRKIFLPSSDDIPGPSWRRTECQPHLPPAKRYKRTYKINPVNFSPSEADASPEQKILKVQRITSTPVNKTIKRSISMHQTPSAIVGDFGLSPIKKKPMVFESFGRSKSSVARFDDDSLDFCDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1W1</accession>
    <name>A0A0N4U1W1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4983</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1W1"/>
    <dbReference type="STRING" id="318479.A0A0N4U1W1"/>
    <dbReference type="WBParaSite" id="DME_0000062301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000062301-mRNA-1"/>
        <property type="gene ID" value="DME_0000062301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="568"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="866"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000062301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122229" checksum="34B736DFE959BE1A" modified="2016-06-08" version="2">MEIEKDEPTTIVLNTKKLSKMEELPPENEIISAFEDVLNKMDLPPDKMRVLRNYDLSKKWDLVCDQRKMYAAPDPSVYLQKLTIYSDKKSLKKKKKLLGDETSTEVLKHIEISLRTNSIDWVRLFLSEANNGLQILVEYLSQLQEAGGWGNFDIGNFANSSNQLAQINSSTAMLNSINGDAAQFSSGNGNDEKFNGGSIFRRPTLNKSKTLKNIGDRDDDIHVCVSCLRAIMNNKYGFNMVFSDPQAIYCIARSILHQSLRTKALVLELLAAICLVKGGHELIIDAFNRFRTEYREVYRFQLLFSFFRYPPEFHVEFMTSCMQFFNILVHSTENMNYRSFLQYEFTLLGLDDYLEILKSNESEQLQTQRIAYLENKIDVTTLVDEAEKKVEIEAENARLSDELSKTKERLQEVEADYIARLAHLDRRLKELNAEKEKLLKERDSTLSTMRRTLNEKDKVNREQQAKLESRIQELEKIQENMKAGLLEVKRSSVVSSSSAKSPPSPPPPPPGPHRIMESNVASKDEPNKTSIPPAPPPPPPVVSISCPPPAPPLTKNVLSPPANDVMTIKKVYNTKNKLPLLNWCPLKPNQAKDTVFSNLDDEKIMDKIDFSALEDKFKIGVVKHVDTQESFSHSVSQHSPSSSGSGSTSARKNTILDTKRLQNIAITCRKLAMPASSIMAAVHRMDLKALPAESVDILQKIAPTQDEMVKFRDYENQYKNFSDLSDEDQFLAELVKIERFDHKLKIMSFMATFDESADLLEPQFVNLTAASKCVREATKFHKILEVMLAYGNYMNSGRKGAVYGFKISSLDTLSGLKSSVERSLSLLHIIAETISKSFPDLLTFPEQLKFADKASGIMWEAVLADMRELEANYTLAKKERELKGNECPPTLINFLEDCEKRINNLQQNCRTAAEAFNACVEFYGESSRNQQPHLFFSRLLEFTKKFQQALQDNEARHALEQRMREDQNRREKIRLRSGRKGDEEMINELEQRLMMVNGDGCPFPKRGQGSKLDSSQIKDGDFEKIMIGLREGAYVAFDGPQNVKRFSTTSGPARIPPPVEPKPVRVVREPPRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U248</accession>
    <name>A0A0N4U248_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PRKCSH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5083</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U248"/>
    <dbReference type="STRING" id="318479.A0A0N4U248"/>
    <dbReference type="WBParaSite" id="DME_0000072301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000072301-mRNA-1"/>
        <property type="gene ID" value="DME_0000072301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF5">
        <property type="entry name" value="PROTEIN OS-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="6">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000072301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="767" mass="89131" checksum="D344CA6DA96B12C6" modified="2016-06-08" version="2">MAYFDFNELNEIAYDIAIDDSPFGFDKFKISKESLLLANEYGKKFFCRLPKLPSNSESEKNFKKQNLTVNLISEVASAAFYVKNCVSRNYGWWTYEVCFGQEVRQFHGDGSLSDNSAIFLGFYGNDSYVDESKKGPYYEQFYSNGSVCDLTNHARQVRVMYLCDENLQTNEAYIASVEEPSLCQYKIAIKTGSLCKLHPFNSVNKRRPKLKIQCHPVLNQVEADAYIQKKINEAKLKESMLKEANELLLKADSIQRQRLARKRLSLAHLGDEKMESEIELKLVSEYKAAASKASTLRAKAEGLEIDLHIISDSLFPTKQQYISDEDEDRGNIYWYFMDRFWDRSFYPVKVAYARPRRNFNNLLRKGPLDFLIQYGGQKTDNYKQFLADVDKGFYSEEDLEELIGPLNKAFSEFLLLSMPNLASCNYIPGISFFFKDTSIYTSRSSAFWTDSEVQAPIFRYFEKHVMNNNLDQSIFDADDIMAKIARQLLQIKSALKSKSPEDDYFFTYKKIEELYEKFEQSFNRGIKLSDIKMRHLEHLFEDAFKNGNMDMVDSYPVKNLKLENIQLLHTDIYQARTVELDGKKTNLESFREPQPKSEMNEAMQGNVLDDEENAKLRMFQRAKRKNLRAKIEEYLDRDDFIGDKKRQGDVKQMIEQIKTKLSGIKDLLVETGLFNSDKVEFHLVTADGDTADYKNYKNVQKGDRILVAMMKAYIDEYDMVKIEADRYENLRKGYDFDAPDESIATEKDDDIISDFKAKLLPILRDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2E8</accession>
    <name>A0A0N4U2E8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EOG090X09DI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5209</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2E8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2E8"/>
    <dbReference type="WBParaSite" id="DME_0000084901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000084901-mRNA-1"/>
        <property type="gene ID" value="DME_0000084901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000084901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34763" checksum="A4136E5DD576EB9B" modified="2016-06-08" version="2">MRLHEDLARKGSTNENTTTSISRSAFTVFSCRPVVLFCELLLHAGELREFVCTQQLPLESIPPSFKGHLVRYIYKLTLGVQHVKSPIKLLNIPLRVIQSDLGITFPSVPKLSNPFIANKNTGPSIIDLTTEATDCITAPHGSSSYAITNSRGKVASFFLIKKAFKLGEDIIGRFIFDNCEVRCLQYTVSLQSVETLVAENSDLNLSSFISTHVTEHAVCAYWREALVKLQIPLSATPTFYTDTVHLKWRLHFEFITNDDFKFDVVEGLSQAPDSLNIETMTWNLDIKVFPCNPHNAALTSTNFLSISSMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2I8</accession>
    <name>A0A0N4U2I8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5254</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2I8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2I8"/>
    <dbReference type="WBParaSite" id="DME_0000089401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000089401-mRNA-1"/>
        <property type="gene ID" value="DME_0000089401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842031at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF125">
        <property type="entry name" value="PROTEIN MALE ABNORMAL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000089401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20719" checksum="E6527C1471F1C617" modified="2015-12-09" version="1">GSSRDSSGYSLCSSPEVDIVNENDQKRYYCQRCLNHKQQHPRKGHKPFCQYANCECADCRMVEERRRLNNMLSSRRVGSSNGNNRSTNGKKIRDPKCALCSAHGDKQPLRGHKKAQCPFLKCGCHLCGLVENRRTLMARQIKLRRDQQKQRKAQLSAKLNNPEMAENTLNLVQGILNIYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2V1</accession>
    <name>A0A0N4U2V1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5389</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2V1"/>
    <dbReference type="STRING" id="318479.A0A0N4U2V1"/>
    <dbReference type="WBParaSite" id="DME_0000102901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000102901-mRNA-1"/>
        <property type="gene ID" value="DME_0000102901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000102901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31512" checksum="4604FD3E9B3F656C" modified="2015-12-09" version="1">MSADRIFVVTGANKGIGYAIVKGLAQQLSNGVIYLTSRNEKLGKESFAKIVSELDDKKKHKIRYHQLDITDRKSIDNFAVYLKKEHDGFDVLINNAAFAFNHNASEPAELKARITIGTNYYGTKQVCDILFPLIRSGGRVVNVCSQMGVLDHRYSDEVIRRFTDPNLTTADIDNIIKDYEQACIHNNRREKGFPESAYSISKAVMIALTFIQAKELAARNIIVNACCPGYVKTDMTSHKGTLTIEEGAVTPIYLATLQENEPNGEFIYLCKPINWVSKRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2V3</accession>
    <name>A0A0N4U2V3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5391</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2V3"/>
    <dbReference type="STRING" id="318479.A0A0N4U2V3"/>
    <dbReference type="WBParaSite" id="DME_0000103101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000103101-mRNA-1"/>
        <property type="gene ID" value="DME_0000103101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5832178at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000103101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47807" checksum="200868ADF67B88FA" modified="2015-12-09" version="1">MLSGRVSPRFEEVSDTRNPPKMLPNGDVYGDGRLKIHRIPLCTTALCTVSHVTSPSCIWMKPINHITEKLQIYDNSGLIHSQAFHEDRYVMAPIREGVYGRARIRAIIEAKNKAIENLIDTYVKVLFIDEGKTQWLSSKCLAKMDETFAFHPWQAIAVCLFKVSPFRDGLTNEKDLKWSEEEISSLRKIFKKFELFRIEAVLNSVQCNDYHDLVKTNLLIKVNIFGLESENDEMGFSIAHMFAREQGNTVRLDRKLYDGLFQKIYYPDEAEFCITDIMGLETWQKIFPEQNTFGTLDNLELKKLDWLGNEIGREIPLVDVDWLNEQGFCHKGEYLVNVEGRSTISPYEFYARFLKSTHSRENISEIEAVNGNSVQFSSEDDAMIAANNVLVELADELNSFYGHPRNRRIINALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Y0</accession>
    <name>A0A0N4U2Y0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5421</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Y0"/>
    <dbReference type="WBParaSite" id="DME_0000106101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000106101-mRNA-1"/>
        <property type="gene ID" value="DME_0000106101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5802741at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000106101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21136" checksum="1E7D3782C61BF5CB" modified="2015-12-09" version="1">MASILYGSWESIIALLLILSINRAATIILNETSKLYCHILMLLGTMFGFSIFVMMITPWFTGRYIIHFHSWAMDDDIVNYMFNEISFGTNAVLIILTFINHVIIIFCLIFKLIFEVTELSFKAEIKLLIQMSVLFFYSSSITFISRYSTTLFRGIRWPYLLISFLWMQFPGVNAILLVFTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U349</accession>
    <name>A0A0N4U349_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIRS_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5501</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U349"/>
    <dbReference type="WBParaSite" id="DME_0000114101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000114101-mRNA-1"/>
        <property type="gene ID" value="DME_0000114101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000114101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8477" checksum="D535A52E31258322" modified="2015-12-09" version="1">MAGAFLDKRKLKAQELVELPASLAKSYLCKLSGEFATDLARSIGCPYAGKVLLRTDQGKEGQTVPSCSFASVELQFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3B3</accession>
    <name>A0A0N4U3B3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5572</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3B3"/>
    <dbReference type="WBParaSite" id="DME_0000121201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000121201-mRNA-1"/>
        <property type="gene ID" value="DME_0000121201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810331at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000121201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5120" checksum="87E3B0024AD35EDA" modified="2015-12-09" version="1">MPGSKFYDGKKIILPISSDSTIQLYDHWIHQGISSLIAIYGKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3C9</accession>
    <name>A0A0N4U3C9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane protein BRI3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brain protein I3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5589</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with BRI3BP. Interacts with MGAT1 and IFITM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRI3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3C9"/>
    <dbReference type="WBParaSite" id="DME_0000122901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000122901-mRNA-1"/>
        <property type="gene ID" value="DME_0000122901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841096at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="BRAIN PROTEIN I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000122901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12529" checksum="AC23B18EAA28EA2C" modified="2015-12-09" version="1">MAYPASAAPYSRGLHDASFPKPYLPPYSLQPMSQPIPPPLPATPVAPTTQIHVIHSERLPGNCAYCGVGTVRGETDLCCLMCLIVVAIFTFPLGLFVLCCIPCTVHRRCSSCRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3L1</accession>
    <name>A0A0N4U3L1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5679</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3L1"/>
    <dbReference type="WBParaSite" id="DME_0000131901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000131901-mRNA-1"/>
        <property type="gene ID" value="DME_0000131901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000131901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14215" checksum="2698F2A98470F5A8" modified="2015-12-09" version="1">MDNVFEEFLDFPVESLENLETFNSLNEFEQDLLKNESKLCEELRKLDKIIEHEESQKRLPSGKAREKNLAQLCAKKDLSSSGTTVNLSSKTLPADILQSQCLSHSFLSRFTKTNPLKAYKVNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3T0</accession>
    <name>A0A0N4U3T0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5752</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3T0"/>
    <dbReference type="STRING" id="318479.A0A0N4U3T0"/>
    <dbReference type="WBParaSite" id="DME_0000139201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000139201-mRNA-1"/>
        <property type="gene ID" value="DME_0000139201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000139201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="52720" checksum="905C3DEB076810E9" modified="2015-12-09" version="1">MVDEKGMKCDQSLGSSLAHNISWQVFSRIISFLINMYLFRRVDGSLIGVVNIKPVLFPFVALILYYCLWFPFSATPPTSLVPSYSFALFCFGFSSWLESLAEPFIIVSLRLAMNAEYAFLQSLLTVLQRLLVLIFITSGVLSHIDAFCFAQDLSILGTLIVHSVFKQILTDGTAYVLTFTSYFTLSTKGAYDAVDKLGSLVARLIFAPLEHSAFLYFSSNIKRNVQLDEQDSKNVKKATEVLIGLLHLIVVIGMVISVFAAPYSYLAVAFYGGDLLVKNSGILRGSKKHVGQSSKECIIIEYGRIGGSEVLTPEFRSIDISALNFLGAGLLRLYCVYIVIIALNGITECFTMATMTTYQVLFLKYFNVFLNIYLQFAVVFSCWIYIVQYLHKGISVMTVLPTLSTIFLLLFSLLILTLSLLIFGSTGGIIHNGAHLAVGGALFFFVINHIYHQDISLAHFVNSYLYHLSTHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4J7</accession>
    <name>A0A0N4U4J7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6071</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4J7"/>
    <dbReference type="STRING" id="318479.A0A0N4U4J7"/>
    <dbReference type="WBParaSite" id="DME_0000171101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000171101-mRNA-1"/>
        <property type="gene ID" value="DME_0000171101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="1">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000171101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34251" checksum="C05E185E42E389DE" modified="2015-12-09" version="1">MEAEMADQNSKIKEMTLDEANEVNGLQQDWLSSTIPWGSAWLKSAKEKTYSTLTLVKKDLSELSDAVATEATALASTTVESIQHIVGFDNVENETTNEQPGTNVEQNSFGLNWASKLPPLSSIADNAWMKSLVEAVKNIGQEDTTIGEDEFTEIIHPKQSSASKPAKKFALSTDQLCLLQTDRMTYSVEPDGDEQLYKLWKDEFNLAEHDVEIKSLLSNCPNMRVIYQEMVPSSISDLHFWQRYFYKVHQAELIAQCDNDLTNEDFRINAKSPLKQNFSIKSPNRSIFFFDTMITDRFQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U521</accession>
    <name>A0A0N4U521_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6283</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U521"/>
    <dbReference type="WBParaSite" id="DME_0000192301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000192301-mRNA-1"/>
        <property type="gene ID" value="DME_0000192301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000192301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21962" checksum="9562C7AA01B13D57" modified="2015-12-09" version="1">MLYLFHAIRLVDSNHVVQEARDLALINVLFDAISYRRRVFSKFEQQASKNCRPPLFVRGLPLNTQKKIINIWKSYDFNSKNCTLQRRKQRLVLLNQPRNLYNLLVPPRVPCGLPHFIERLTDYLQEEIRLIWLNYAPGEPCFRELDDELNLLQKNGIAIESFFIPPPNSLKRSDLYTKIFHPNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5D5</accession>
    <name>A0A0N4U5D5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6412</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Elbow/Noc family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5D5"/>
    <dbReference type="WBParaSite" id="DME_0000205201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000205201-mRNA-1"/>
        <property type="gene ID" value="DME_0000205201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874052at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN ELBOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000205201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37011" checksum="651A43BE5861CE69" modified="2015-12-09" version="1">MLAKTCETIGLPDTSNRKLLKDEKIKEGHSPNNSSNEPKKDDLSPLSKKKEEPKSPHHRSHSPLLGKKTPVSSEPSTSTASLQPLLMNGRYPMFSSFATGFPPFYPPVMPTFPTLPAFTGAFPTGAPFLRCPDPITCKGCPATMMSRQCVTPGCTSCTLHNPGSSSVDMMMFSPSLFSAYSPLMAAPLPPTSKHLIIGMIREKKSEIFSSSVQIAYQNMMAAASGQTTKHICNWIESNSICGKSFPSADELATHMKCTHATSSTPSNITVDTKSASPRSSTTSVMNHNSLRFHPYMKPNNLLPNAISSPLGLPSFPTLPSFPSPAAFQAMYRQGMMATMPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6B0</accession>
    <name>A0A0N4U6B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PABS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6807</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6B0"/>
    <dbReference type="WBParaSite" id="DME_0000244701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000244701-mRNA-1"/>
        <property type="gene ID" value="DME_0000244701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000244701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20425" checksum="DB2441BC8701DB26" modified="2015-12-09" version="1">MFICRTMLSYNWIQLSSVAVIIPNHPRPRYLRYILSAAYATGAINMDETIPGDALIIGLGGGSANNYLRHATKNINVTVVEIDPTSVDLAKTYFGFNEDERQRCVEEDGAIYIRKCAKRGQKFDLIISDTSQENNTYVQAPSDSFLKLSVVRYFPEILKKTGVLIMNCLTSKILSVEKVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6X7</accession>
    <name>A0A0N4U6X7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piezo-type mechanosensitive ion channel component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7070</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6X7"/>
    <dbReference type="STRING" id="318479.A0A0N4U6X7"/>
    <dbReference type="WBParaSite" id="DME_0000271001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000271001-mRNA-1"/>
        <property type="gene ID" value="DME_0000271001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="2">
        <location>
            <begin position="7"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000271001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51978" checksum="011E7E99F52DC18D" modified="2015-12-09" version="1">MRGQVKVLALIAQVIYQISESILHPQIDEYTKACNSSTLNFWFRQLGFVRIKSDAGFDSIRVILPEVLSLIATVVTVILCTVIPHIHHTQPAQEEAESHQSFHRSERSGILPLLKKSSEIIIVLFLGFVGSVQPCILNLVYFIAFLFTSIWWSSFTRIRRNFSNLGKLIIVAYVAVHICFLYVYQIPFIQLFIARNSFPARLIGFVPLIHTDCDSWWSIILISKDYWTAYVNIISIVLLYHVLILQHRWTYFGTKRCMILGSGGSSVHEEIFDMSDFTASSSNLQMDNDAIISEHTRKMLLAEEEREAHLNIPLPRVTSAMIDHYRIQSFILTSPWLPSITSKGLIIAISFLIHHFYIFALISMMVWALLYHSIFGLIFLCLACIFWVFKDSRTASFRFSPFIVVFASVLLTIQYICGLDIAEEWQKYELLELFGIAPAQNRTDAFIDLVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7A0</accession>
    <name>A0A0N4U7A0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CC2D2AN-C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS84</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7A0"/>
    <dbReference type="WBParaSite" id="DME_0000285501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000285501-mRNA-1"/>
        <property type="gene ID" value="DME_0000285501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868159at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CC2D2A N-terminal C2" evidence="1">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000285501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20980" checksum="529D3ACF10B10A98" modified="2015-12-09" version="1">MNFTTELLISELKTAKENYVHLGRSIEKNWNDLQRLRIEQGYASRNLAVQKTEQSDILNFYNQWFDTADTPVYSIIASEEPQINNSKPQHEIERLSLISKYRYQLIIHFNKISVCKTPYRALNTDFSCNFDEIYRLRVSFIAVASLLNHYMEPFFLLQHETLFDLAEFSRWDEASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7H6</accession>
    <name>A0A0N4U7H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS168</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7H6"/>
    <dbReference type="STRING" id="318479.A0A0N4U7H6"/>
    <dbReference type="WBParaSite" id="DME_0000293901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000293901-mRNA-1"/>
        <property type="gene ID" value="DME_0000293901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000081">
        <property type="entry name" value="Empty spiracles homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000293901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21554" checksum="642B7E5403013EA2" modified="2015-12-09" version="1">MICIGNDNKCYTSNNCEYGNDVENKSKNEPVQQTLSYFDVLLPHVQMASTNPFILSLNSSNERKLWSQQWVQLLQQSSCQQFRENSINLFLQPFRKNKRIRTAFSPQQLVQLEKAFQSNHYVIGNERKQLAIKLSLTETQVKVWFQNRRTKYKRIKCNSENNNDIGSNDSTNPANIENNNNDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8F9</accession>
    <name>A0A0N4U8F9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7487</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8F9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8F9"/>
    <dbReference type="WBParaSite" id="DME_0000332801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000332801-mRNA-1"/>
        <property type="gene ID" value="DME_0000332801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000332801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28907" checksum="26F7C6A0B326DA0B" modified="2015-12-09" version="1">MLPTLEKDLTAMDAREIKKSTKQDIINRKKIEKLSEELNEQRSRRHGYVPSATPSLQKSFDRLGCLMSDFGSDSYSNRSLPFIFATALYSFQALGAKHELKKEKFSRELSFNRGDVLRVRRIIDSNWMEGEKSGKIGIFPSSYVQVDSLNEKVWLIAQFPFYARNSNELSLKKDEIILYKRRIDENWLEGINERGQIGIFPKAYVRDIDNSLAIVQNKNGPNDEPNRPKTPKFLFSPSSLVLLLEKIQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8N2</accession>
    <name>A0A0N4U8N2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS282</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8N2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8N2"/>
    <dbReference type="WBParaSite" id="DME_0000341601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000341601-mRNA-1"/>
        <property type="gene ID" value="DME_0000341601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000341601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42892" checksum="E971D1D80712BA95" modified="2015-12-09" version="1">MHLPSRARVYADVTQQKPREYWDYENHMISWGNIDDYQLYKKIGRGKYSEVFEGLKTTFDQKCVIKILKPVKKKKIKREIKILENLRGGTNIITLLDVVKDPISRTPALIFEYINNTDFKILYQTLTDYDIRYYLYELLKALDYCHSQGIMHRDVKPHNVMIDHEKRTLRLIDWGLAEFYHPRQEYNVRVASRYFKGPELLVDYQCYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYDYIDKYQIELDPRFNDILGRHSKKRWERFVHSENQHLVSVEAIDFLDKLLRYDHQERLTAKEAMQHPYFYPVVENEQRFKQEDIPMGIPMISSAGVVSPTASQSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U943</accession>
    <name>A0A0N4U943_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7592</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U943"/>
    <dbReference type="STRING" id="318479.A0A0N4U943"/>
    <dbReference type="WBParaSite" id="DME_0000358701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000358701-mRNA-1"/>
        <property type="gene ID" value="DME_0000358701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000358701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="794" mass="93418" checksum="DB8CB091AFB27568" modified="2015-12-09" version="1">MKKEHKVSAHLTVTEQNNEELSGEGGEYVKKKREYKNSSSSDNGKSRDKSRKRKHSDNDRKDRKKRKKKEKKMKRHRKNRKYKKGSSDLSDEELENLEKKKVDIEKKLNESTVENKHKSSTLGNSEQKNVNESKGISCGEEIFSKRATIEERIIENEKNGRLNMSIDTFVDKDLTIKVVGKIGETSLNRDSEESTNDHKDEKDEKVLSIKLKSRKRYDIKEDNKLDYESSDDGELRKNMHERKKRPGIDTIIDKEEKGKEKMLGDNIKRKLDTEEIPRNESGKKKRFSESDNENIGKKTKLRGERNQKGHEVARHENDERRRRHTKSPESKRHRSPVSSRYRDSSRNRRRDNSSERRYDNSHERRRGDSRERGRKEIYEERRHDQSKERRIRRSRSPLKKRIDIQIRSHRSRSVERRRDYRSSSRDRARRRTTNNNIFRGRRRSGSRDHKRIPSRDKKQNRGSSRDEKRSGRPRRHSSKSRVKQDDAGKSDQSISQKKEIVRRHVHSNSMSSVEFNDSDEEEQKKIEELRRRRRQLLMEMEKQNGNDNRFAKKPLRKLSSEKYNKIFVSQENTANSNEILKEAKTEKRTQQDNKQEENDSYEEAQRVCFETSPSTECSEQNAKFDCENSKGREESVVTQDFENSDNDISNSESPTKGNIVLKEAERELEKGYDSDISNSSTPILNSDNDTPGDFFDELKEKMVHIKGQEESEVDRALKKAVEEEAEEQRRQCGEDVGKIHRDSGDNVTFDMFATDSELPTEILASLMVFTVFIIHSLEEGSYNRFGPRCCKCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U961</accession>
    <name>A0A0N4U961_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7612</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U961"/>
    <dbReference type="STRING" id="318479.A0A0N4U961"/>
    <dbReference type="WBParaSite" id="DME_0000360701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000360701-mRNA-1"/>
        <property type="gene ID" value="DME_0000360701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000360701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15709" checksum="DF9DD6B704B5FA79" modified="2015-12-09" version="1">MGCGRVRTKTVKKASRIIIEKYYTKLTHDFHTNKRICEEIAVIPSKKMRNRIAGFITHLMKRIEKGPVRGISIKLQEEERERRDNYMPDISVLDPQMLTSIEVDQVTKAMIESMVRNFLKIYLLFFQKIGRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U980</accession>
    <name>A0A0N4U980_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RT_RNaseH_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7634</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U980"/>
    <dbReference type="WBParaSite" id="DME_0000362901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000362901-mRNA-1"/>
        <property type="gene ID" value="DME_0000362901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000362901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9933" checksum="ECE19B74BE8711D3" modified="2015-12-09" version="1">MDVASQAITVHTLSKYRVDITCLSEALLPYFESQVIIYPGLQQRYWLYHCDASDNSGRNGVAIILSDKTHSDLIEWKPASDHMAYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9L1</accession>
    <name>A0A0N4U9L1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7788</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9L1"/>
    <dbReference type="STRING" id="318479.A0A0N4U9L1"/>
    <dbReference type="WBParaSite" id="DME_0000378301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378301-mRNA-1"/>
        <property type="gene ID" value="DME_0000378301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6413693at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="205"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="293"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="378"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64071" checksum="3618BA5D01C15540" modified="2016-06-08" version="2">WVKDGFGLNTDRLIDGIYPRYKIEGSVSKGEYNLRINNISIDDDDIFECQMQAAVNNPTRISNKAKLTVLVEPQLPTMFLEDDVLNVIAGQYIQRSCVSKDGKPPSVIGWAITENNSTSIIRSWLGDSLQKFDISQFKLSTKESQYAHIIEDIRRNTQQLYTVISNISFVPKIDDDGKYLTCITSHATYSSPKSISFALDINFSPVVHIEINEKSEMRENGSAILHCNIKAKPTTNLQIIWFRNDVIIESAKTDVILLPNLNIDHHQSKYTCLVSNIIGESSDSIILNVTYGARIMSTEQHQAVNPGESAMFNCEAIGNPPPKIIWKKIGDGQVIAHGSSLTIESVQSWHRGEYECKATVSGFPSSRLINFLHIKGPPSVSVREEIIAANGETIEIICEVKFYFNKIVRGRPQPQDVIWLLNGSPIEYGRLGSRLQIHQVPRQFGVESKLIVQGVKNSDYGIYNCTAFNELGSDYQTIRLKSKSIIDALIKDPTIKVEPIDGGPYPFPSLNPPGITFSDNYISTMGTNPDFDYIGNSPNFDRLYPRVNNGTAPPANDCFAFDDSMNNHQSYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9U5</accession>
    <name>A0A0N4U9U5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pribosyltran_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7883</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9U5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9U5"/>
    <dbReference type="WBParaSite" id="DME_0000387801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000387801-mRNA-1"/>
        <property type="gene ID" value="DME_0000387801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000387801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38983" checksum="884FF1A07617562F" modified="2015-12-09" version="1">MSGVYKDDESTGMVLLAGNSHPDLARLVSDRLNVKLGEVSIYNKTNRETSVEIRQSVRGKHVFIIQSGSKDVNNNIMELMILAYACKTSMAKTITVIMPYLPYSKQCRMFRRSAVPMKLIADMLCKSGAMRMVSLDLYKKEIQGFFSIPVDNLRASPFLLQYIKENIPDYKNAVIVAKSPGVMNKATSYADRLRLGIAVIHGEQKDVEESGLEDGRQSPPPQHDSPDLAVPKEKPPLTVVGDVGGRIAIMVDDIIDDAQSFVAAAHVLKNRGAYKIYVIATHGLLSADAPGLLESSPITEVIVTNTVPHEVQKMRCHKIKTVDISLVISEAIRRIYHNESMGQLFRDVTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA59</accession>
    <name>A0A0N4UA59_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS378</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA59"/>
    <dbReference type="STRING" id="318479.A0A0N4UA59"/>
    <dbReference type="WBParaSite" id="DME_0000401401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000401401-mRNA-1"/>
        <property type="gene ID" value="DME_0000401401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000401401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16321" checksum="4B3D6735C0A2F8BF" modified="2015-12-09" version="1">MNIKREASDMIKYYEGENHETDSAAGLYFIQNIYVMVIHMTYWLLALTSVQLSNDYLTGYFISGFVDLPPALISVFLFCFALLIAEMIPTSESFGDRTPLLILAILSVIAAFLILTVPETKGKRMPEDANEFDAGWFLAWLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA77</accession>
    <name>A0A0N4UA77_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS398</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA77"/>
    <dbReference type="STRING" id="318479.A0A0N4UA77"/>
    <dbReference type="WBParaSite" id="DME_0000403401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000403401-mRNA-1"/>
        <property type="gene ID" value="DME_0000403401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000011">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000403401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17044" checksum="D4C68B5A79F206FB" modified="2015-12-09" version="1">MDFMHKAIEEACHGVQAGDGGPFGAVIARQRHIVAVGHNMVLLNNDPTAHAEIIAIRKACAVLKTYDLSGCVLYTSCYPCPMCMTASLWARIHVIYYSATAQDAAKAGFDDKIFHDFVKDPKSDNIRRLEQLNVPEVLKPFEMWAAKEDKTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAC5</accession>
    <name>A0A0N4UAC5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS454</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAC5"/>
    <dbReference type="STRING" id="318479.A0A0N4UAC5"/>
    <dbReference type="WBParaSite" id="DME_0000409001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000409001-mRNA-1"/>
        <property type="gene ID" value="DME_0000409001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="203"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000409001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="550" mass="61742" checksum="E0D61EFF550FCAD0" modified="2015-12-09" version="1">MVLRLNGFRLLLTRRGIFASTSHFAVLRCLASNQREPYVPVPMDPVQPLWHRLFKNKIIAKIDCHKTLYEAVCEQLRNKIDLFLAIALALFITSFSFGLYDDLNVLESIKTSFSDTLNNYRKRKIYKEKLDNDKKVSASFFVEAEKKYEALPIIESSVATKGHSVINNIKEIIFPSKREKVKKELNEKVCLLYKKLPEEIPYLLIGGGAASYYAAITIRGRDPCAKVLMIGDELELPYDRTPLSKNLWWSGADDASETLRYKTASGRTKNIFFENANYFVPPDEINGTKHGGISLVMGHRVTKLDPEAHIAYLDDGRTIKYKKCLIATGGSPRKLAVIEQSKKDIKERVMYFRVVDDFKKLYKIADGCRSITIIGSGLLGTELAIALNTRFGPTGLIVNQVFPENGNLRKIFPDHLSQYTTMKLQNNGIRVITGQNIVQISKDDGYGCLMLHLSSGEVIKTDFVVAAVGIVPNTELAASSGLEIDKNNDGFIVDAELRARSDIWVAGDASSFYDIKHGRRRLEHQSNSEATGRLAGFNMTGGNFLIFYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAX7</accession>
    <name>A0A0N4UAX7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8214</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAX7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAX7"/>
    <dbReference type="WBParaSite" id="DME_0000433101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000433101-mRNA-1"/>
        <property type="gene ID" value="DME_0000433101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6146255at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039902" evidence="1">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000433101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17997" checksum="1658AEF1DEF2B448" modified="2015-12-09" version="1">MPNFHKQSSLNLMKLISETLTLALDTASATIDANDTSSQMVHAISIQSGDSKAEQRYWLWCFGQLGTKWRSDCHADKAHSVLIEWKPVNDRMAYAHYKGKFCNISVITIYSPTLSSDDHDKDKFYAELQLLTEPKHDMIIIGGDWNARVGHNAAVINNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB83</accession>
    <name>A0A0N4UB83_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Component of oligomeric Golgi complex 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB83"/>
    <dbReference type="STRING" id="318479.A0A0N4UB83"/>
    <dbReference type="WBParaSite" id="DME_0000444701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000444701-mRNA-1"/>
        <property type="gene ID" value="DME_0000444701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000444701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23428" checksum="D2A06DA11DBC25EF" modified="2015-12-09" version="1">MAKTIELDREKYEKFVKERLEADYRIIVEAMNKVVDEIREYEALLLCISKLKESQIDEGLETMVNVGKNIFCEAVVTKCNRLIVKLCDDLFAELTLERAEFFIMNRIKLLNERAGVYEREAFSIHARKDLILSSLDQFTLNHQNASKEFPDDIVRIIAEISKMLAQELLERSAINARDGLSNQVTLENFHRIIVQAILDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBJ7</accession>
    <name>A0A0N4UBJ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Testis-expressed sequence 264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8462</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBJ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UBJ7"/>
    <dbReference type="WBParaSite" id="DME_0000457901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000457901-mRNA-1"/>
        <property type="gene ID" value="DME_0000457901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2140079at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000457901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29244" checksum="1666F14504D21F15" modified="2015-12-09" version="1">MELAYIFPFSLIALVFFIWKLYRSGFFDNIEVSIVEDPPFISKSLTVYYKYCIGRYKRGSGVLVEVARLMPGEATTFGIYYDDPEETREELLQSAVGVVFCEDDRNLYEDKYGVQLTNCGYDKLVIQPVQRAVVARQRFNGIFSTFSLENFLYPKLKTFVKIHKLEINLFVEFYSNGNVYVVLPLDHQNEFFVPQLMTMDELETKLARRKWDSDVESDSRSDTEPEEDPGSEEEVRIASSNVIESQDDKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBL5</accession>
    <name>A0A0N4UBL5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8483</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBL5"/>
    <dbReference type="WBParaSite" id="DME_0000460001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000460001-mRNA-1"/>
        <property type="gene ID" value="DME_0000460001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821797at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608">
        <property type="entry name" value="PROTEIN CBG07207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608:SF4">
        <property type="entry name" value="PROTEIN CBG07207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000460001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15107" checksum="D179C52DD1ACC5BC" modified="2015-12-09" version="1">MLGLMNSPNEYPYDFYSANKKDSKIEFSKQKTMKVAYLKDGRKLLNGKLLDEKKAEELWKDLIIRSNAKKISLYTNDFSEEDQLIEDSVERNEGSKGERIDEDEETVYFSEEIQLNSELDGHKLNMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCB4</accession>
    <name>A0A0N4UCB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SRP54_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS521</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCB4"/>
    <dbReference type="STRING" id="318479.A0A0N4UCB4"/>
    <dbReference type="WBParaSite" id="DME_0000490001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000490001-mRNA-1"/>
        <property type="gene ID" value="DME_0000490001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="3">
        <location>
            <begin position="316"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000490001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51184" checksum="D558682C0A67D885" modified="2015-12-09" version="1">MIELFTIFGKGGIVLWCFQEGSQLYRDTINQFIKEVLMQERVNSSVFKYNNVMMKYRLDNEFELIVYQSAIQLSYGDQLLTDVHRKFRDMYKNVLSDNKLLFGYTNRMFDGFREIYMELQKSSFVKPEKIMRKFEESDKSKKTVASMLERPSDRGVKQQIKEKELKSKMMQQQFSGHSPINIQKNNINEIVGSPQSSPKADLDDGEIRRKRAEFFKKKGGKKASETEKSSLVDIKKGKKARTWGVLHNGNVADAQVLDYSETNEKASVVEEDRKFLEEQKQFVGQMKGELPGLDQNQNLDQNQEENLNGQDEVKSENDGWFSAFKSLVGNKKLTSKDIGPVVDRMRENLFAKNVAAAAAEKLCDSVAAKLEGKVVGTFSLVTSIIRESFREALTQILTPKRRVDILRDIIEAKNENRPYVVIFCGVNGVGKSTNLAKITFWLNENGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCY1</accession>
    <name>A0A0N4UCY1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8947</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCY1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCY1"/>
    <dbReference type="WBParaSite" id="DME_0000514801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000514801-mRNA-1"/>
        <property type="gene ID" value="DME_0000514801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000514801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5774" checksum="7CAF0D78F457CD98" modified="2015-12-09" version="1">MVRLVFRPYTRVGRSICTSEPLRTSTRVSSGFILLRHSSPSFGYQRIRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDS9</accession>
    <name>A0A0N4UDS9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS610</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDS9"/>
    <dbReference type="STRING" id="318479.A0A0N4UDS9"/>
    <dbReference type="WBParaSite" id="DME_0000550401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000550401-mRNA-1"/>
        <property type="gene ID" value="DME_0000550401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000550401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22483" checksum="D0C80D7756FB75D7" modified="2015-12-09" version="1">MYQRNLQASLNEMSLPKRIYSNVDVINNRNLNACPNWNCKIENGQKSNQRLREYDAIVMHPSEGFNIEYDYKPPPEQYFAFFSQESPVNTGKLLEPRTFNFSLNFRRDSPVSSPYGYAVKLAPKSRKFGTVIDERIISGKSHPITWFVSNSKTESRRELLVDELKKHIKIDIYGTHGSLICPRNSECEDLLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDZ1</accession>
    <name>A0A0N4UDZ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9310</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDZ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UDZ1"/>
    <dbReference type="WBParaSite" id="DME_0000556901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556901-mRNA-1"/>
        <property type="gene ID" value="DME_0000556901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF8">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="73"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="435"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="258"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="526" mass="58276" checksum="AD93AD26477B5EFC" modified="2015-12-09" version="1">MFNFQILRHFSKRQLKSFSLNISQKDAKIMLNIVKHNNMPLIFIKGDCVGGLAELLALDQKGVLDSWLAKHDYDLAVIGGGSGGLAAAKEAARLNKKVVCLDFVKPSTMGTTWGLGGTCVNVGCIPKKLMHQAALLGESIKDAKKFGWTIPEGRITFNWQELIKGVQDHIASLNWGYRVQLRERSVTYVNAYASFTGFHEISAVNKKGKIEKITADRFLIATGLRPRFPDVPGAKECCISSDDLFSLPYNPGKTLCVGASYISLECAGFLNGLGNDVTVMVRSILLRGFDQDLAEKIRKIMLEQGVKFVPAVPVKYERIQEPTDSKPGVVRVYTERILEDGTKETVTDEFNTVLMAIGRDAVTDDLGLDTINVERSKTGKIIGRREQSISCPYVYAIGDVLSGCPELTPVAIQAGRVLMRRIFTGNSELTEYDSIPTTVFTPLEYGCCGLSEEKAIELYGKDNINVYHNKFIPLEYTVPERTEKDHCYCKLVCLKNQQDLVLGYHILAPNAGEITQGFAIAFKFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEK2</accession>
    <name>A0A0N4UEK2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS806</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEK2"/>
    <dbReference type="STRING" id="318479.A0A0N4UEK2"/>
    <dbReference type="WBParaSite" id="DME_0000581201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000581201-mRNA-1"/>
        <property type="gene ID" value="DME_0000581201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10026505at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016513">
        <property type="term" value="C:core-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.250.10">
        <property type="entry name" value="Core binding factor, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003417">
        <property type="entry name" value="CBF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036552">
        <property type="entry name" value="CBF_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276:SF3">
        <property type="entry name" value="CORE-BINDING FACTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276">
        <property type="entry name" value="CORE-BINDING FACTOR, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02312">
        <property type="entry name" value="CBF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50723">
        <property type="entry name" value="Core binding factor beta, CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000581201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17182" checksum="67FF2D99EF011A40" modified="2015-12-09" version="1">MRWRMPSVVEDQQRRFEADPEIRQLIGPTQIAYAGFLHAPQAERSTSLLQSCSDRQRPHIPLTFTQFGYNSDFVLSSCTVGQNEITFESRFILNGVCVLLRGSLNRETLVGTSTLNYDAENAEIEERKRQEVIANYGERIRAIQRRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEK3</accession>
    <name>A0A0N4UEK3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS807</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEK3"/>
    <dbReference type="WBParaSite" id="DME_0000581301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000581301-mRNA-1"/>
        <property type="gene ID" value="DME_0000581301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788998at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000581301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18264" checksum="F94A0E16E681FD3C" modified="2015-12-09" version="1">NIANIFEFQLVHDCNVQLAQYRNAVQCIGTSQDGAQLRKDLDTYGRACVRSCEAAKSCVLPQLRHEVEFTRHASHFIGCVNACVVEMRRCEALERTFPMGDPSVTPQQISHMEEMLETLENLITVHFSTSESSPAERVTPRRRRAANCRPTCVCSKLKTSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF47</accession>
    <name>A0A0N4UF47_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS979</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF47"/>
    <dbReference type="STRING" id="318479.A0A0N4UF47"/>
    <dbReference type="WBParaSite" id="DME_0000604001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000604001-mRNA-1"/>
        <property type="gene ID" value="DME_0000604001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20684at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000604001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64185" checksum="E1B477323A95830F" modified="2016-06-08" version="2">MCDEDDDEVLLFECGASLAANAFSKFEEIRRSGKLCDVIIVASGVKFSAHRIVLAATIPYFRAMFTAEMAECQQNEICLKEMDADTLEQIIDFTYTGRLRITAANVQSTMEAANFLQLYSIVDECCKFLQCRLHSQNVLGIRSFAMTLGCVSLVLSADRFIHKHFLSVSQGEEYLMLKFDEISTILSRDELLVDNEQQIFEAAMRWLSYDPERSKYSAQILKTVRLPLLKPQYVTDEVASCPIINQSLECRDLVDEAKDYHLMPERRKFLKSFRIKQRCCQDAVGVIYAVGGLTSTGDSLSTVEMYNPAVGKWECTQAMNSIRSRVGVAVMNRILYAIGGFNGQERLRTVELFDPEKKQWKEVCPLINKRSALGAAVVNERLYVCGGYDGISSLSSVEVYDANTDKWTLTIPMNKQRSAAGIAVIDNFIYVIGGHDGMSIFNSVERFNVETEEWQSVKPMGNKRCRSGATALRDKIYVCGGYDGRQFLKSVEVYDPDKDEWSPLSPMHFKRSRVSLVANSGMLYAIAGYDGISNLSSVEIYNVEEDSWTLGSSMIAHEGGVGIGVIPIPAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD9</accession>
    <name>A0A0N4UFD9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9440</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD9"/>
    <dbReference type="WBParaSite" id="DME_0000614401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000614401-mRNA-1"/>
        <property type="gene ID" value="DME_0000614401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="209"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000614401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45694" checksum="7BF1FDD496117363" modified="2015-12-09" version="1">MKVTFIHPNLGIGGAERLILDAAIAMKINGHEVEIVTNHYREDHCFEESKQFSIRTFDIFPQSFGGYAVAFCAYIRMCIAAFYVCISMEQDIIFCDSISVCLLVFRLFRLFGLCKAKLLFYCHFPDQLLTERRNIFKTIYRCFIDHTEAWTITLADVICVNSIFTKNVVLKTFPTLNNRTLHVLYPSLNTKFFDDSPSIIIDGLPEQIKYLFVSINRYERKKNIGLALEAFAELKKLIDEKLYSQCFLVIAGGFDRENEENLLYHRELKEYGVELQISTKQIMFLRSPADEVKVELLKRASAVLYTPENEHFGIVPIEAMYMKCCVIAVNSGGPMESIINGETGFLVESNAKAFADKMALLVKGIINSNEMGYAGHQRVLSKFTIDSFASQLANIVNNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFH8</accession>
    <name>A0A0N4UFH8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1088</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UFH8"/>
    <dbReference type="WBParaSite" id="DME_0000619101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000619101-mRNA-1"/>
        <property type="gene ID" value="DME_0000619101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000619101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17196" checksum="4E75D5255E886671" modified="2015-12-09" version="1">MGGIPVPGRTVPTTRIFELYISSCVPSSKKSATLDYINNLLENFDSEELANKIYNSLFYAVGDVDLKKLMGKWFTVNELINQDQHTGTFTTKQYSKNNDDILIIEGHGKKIGSDPGELLINFGYPDDPCPCESIFFHICKWRYRALLCSIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFN0</accession>
    <name>A0A0N4UFN0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1150</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFN0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFN0"/>
    <dbReference type="WBParaSite" id="DME_0000625301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000625301-mRNA-1"/>
        <property type="gene ID" value="DME_0000625301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000031">
        <property type="entry name" value="cyclin-L1-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000625301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28135" checksum="713CAAB6F0F30DF1" modified="2016-06-08" version="2">MLLDRNYVDLKNQVIKAERKLLNALGFVVHVNHPHKLIYAYLLALGGLGNHELTQRAWNYMNDGLRTDIFLRYHPETIACACINLAASTISRALALPRHPFPWYEAFGASDRDIKAISLILLQLYKRSRAPNWSRLNEILNKLRFGPDSVFAKAQKVEKIADKETERAKAILDKKRKEIISKAAEMEKKQNGRLKEKDGIRRERSNDGEYGTSNGRFFSSPTSSRSRSRSPVEPRRFVFFLRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFV8</accession>
    <name>A0A0N4UFV8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of basal transcription 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1243</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFV8"/>
    <dbReference type="STRING" id="318479.A0A0N4UFV8"/>
    <dbReference type="WBParaSite" id="DME_0000634601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000634601-mRNA-1"/>
        <property type="gene ID" value="DME_0000634601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="62"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000634601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29547" checksum="B8545AF19DB1DAA9" modified="2015-12-09" version="1">MEGETSISKINDKEDDTIDFDFSDGSDIDLKLSLKKRKKIKLPNRRPLKEGEHPESKEQKSGIIYLQTVPPNFTVSRMREEMSKYGEIGRIFLQREKQKSGRKHGRRYVEGWVEFKRKSIAKQVAKYLNAMPVGGKRRSMARETLWTMKYLSGFSFKWYHLNEQLNYEQKLEKMRMHAEISQAKKQASFFAEQVEKGKQLKKLEEKVLKKGGVWDKFQRQIEQRSVIKKKRKSHENQYTGDDLMKMIFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG26</accession>
    <name>A0A0N4UG26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9531</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG26"/>
    <dbReference type="STRING" id="318479.A0A0N4UG26"/>
    <dbReference type="WBParaSite" id="DME_0000642001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000642001-mRNA-1"/>
        <property type="gene ID" value="DME_0000642001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF51">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000642001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32340" checksum="9D6378A5A71EE04C" modified="2015-12-09" version="1">MDGDKLFVAIVIVIKQSTNIDYSRIVNISATMLTTNLLHPKAMPTVTLNVILKEVRVFAGDELFVKILLDSVDSGAIVNEFFVEILGIGRTGWINIHTDKIYESEKEYLKICIPLMTSGQRLPMGRHLFPLHLMIPEDLPSSYESEYGNIRYAIKVSLRSNSENSTCTETFPFIVVARSFFDEVPETIMKTIEFKDEVDFTCCSFPFGTVFLKIVLSRRVFCIGENVNCLLIVRNRTRKILKNCCLLVMLKIQCEALSRYEKINEKKLSEEIIDKILCEAMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG73</accession>
    <name>A0A0N4UG73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9587</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG73"/>
    <dbReference type="STRING" id="318479.A0A0N4UG73"/>
    <dbReference type="WBParaSite" id="DME_0000647601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000647601-mRNA-1"/>
        <property type="gene ID" value="DME_0000647601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000165">
        <property type="entry name" value="Tubulointerstitial nephritis antigen-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000647601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41772" checksum="9CB3EAA8AB94F5F7" modified="2015-12-09" version="1">TCSNNQWQCDSNVCLIQENLLHQVQTGRYSCFHFVYSTSIFSWTARNYSQYWGRTLEDGVRYRLGTLFPEKSVQNMNEILIKPKELPLRFDSREKWPLYIHGIRDQGDCASSWAMSTTATSSDRLSIISDGKIDVVLSAQQLLSCNQNRQRGCEGGYLDRAWWYMRKFGILTDECYPYVSGSTRKPDECRTVKSEYQIDMPIVCPNSSIKPLLYKMTPPYRIASREQDIMTEIITNGPVQATFLVYEDFFMYRDIFNFSGGVYQKMDLSKQGNHYTSQGYHSVRLLGWGEDDLTGRPVKYWIAANSWGTNWGEDGYFRILRGENHCEIESFVIGAWGKGGKKRRRFKIRKLRRRLQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGG9</accession>
    <name>A0A0N4UGG9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAT complex subunit CCDC47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1319</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC47 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGG9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGG9"/>
    <dbReference type="WBParaSite" id="DME_0000659001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000659001-mRNA-1"/>
        <property type="gene ID" value="DME_0000659001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042844" description="PAT complex subunit CCDC47" evidence="9">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000659001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47549" checksum="EC613F1206A97D1B" modified="2015-12-09" version="1">MDTLQIILLVFLYYLNPILSNSHNSHGVVDSDNEFAEFEDDDADDEIIIDKDDNSHNAIYHGDSSQTKQNVPAHFRSNWASYQVEAVVILLLALYMINYMIGRSRNQAIANSWFQDVSTLLQEQFTVVGDDGVSEEPGEGNLIKETDSTYLIWCSGRASCQGMLIHLKLQKRQDLLSVILGLFRPQQDKAVIRIDMDPNEMDSFVLIVGQRKSVTKAVKDVMDLVSYFDSFAFATILGLPQSMTVFAEISEAVTAIIDPVVQSVLRKYENAVDYIHFSDQYSGLKPTEGETYTRLPDTSRVLIFAFNIGNDQAETEALIKTVFYCLEKIKRYRLSREGKSKADKKRQSVKEAFMKTTHQARQEAAQARREEKTRERKQRLLEEEDPEKQRRLEKLEQKRDSKLRQPKIKQLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGL3</accession>
    <name>A0A0N4UGL3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Autophagy-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1282</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGL3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGL3"/>
    <dbReference type="WBParaSite" id="DME_0000663801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000663801-mRNA-1"/>
        <property type="gene ID" value="DME_0000663801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000663801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13787" checksum="9E3BEFAB0D2232AE" modified="2015-12-09" version="1">MQWAYKESNSFEKRRAEGEKICKRHPDRVPVIVERAPNARIRELDKKKYLVPSDLTVGQFYFLIRKRSLLFNKLTYLTIFYENSHNYHLYCIFLNQSEEIEKLIFVYNSVNGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGL7</accession>
    <name>A0A0N4UGL7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1287</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGL7"/>
    <dbReference type="STRING" id="318479.A0A0N4UGL7"/>
    <dbReference type="WBParaSite" id="DME_0000664301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000664301-mRNA-1"/>
        <property type="gene ID" value="DME_0000664301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF341">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000664301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39668" checksum="96F1A9270394A5C8" modified="2015-12-09" version="1">MVIPQLIVIALLFSYIILGSAVFVLTDGTMANENFTDIILFSFTTLATIGYGNISPTTPAAQLFCIVFSIFGIPMTLLTLANIGKYFTKGYWMILVCFGKDLRWRSCEKAKMPLPTVLLLFIITFAFGSLLFYKKGKGFSVDDVYFSVISFATVGFGDRFPTAADPLRLIGMISYLIWGMVLMTTMFSIVSTYLRTIHYLGRSLRGARDVHVWFGGKSMKISQLLEIVATEFNATPRQLKGVLRDLDRLISSAIAENQMLSRKSSRLFKNRYTPKKRIGFSLQEEFPADGINTRFIFSKECDIRHHETIEEENVIINKSFFKERQSIERRQSVDLGELNRRMIAKYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH29</accession>
    <name>A0A0N4UH29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1443</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH29"/>
    <dbReference type="WBParaSite" id="DME_0000682901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000682901-mRNA-1"/>
        <property type="gene ID" value="DME_0000682901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000682901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9239" checksum="ABB487CD732D2AAE" modified="2015-12-09" version="1">MPSNSPSLALSILQLPSIRLIVLWKMMECPREDHSVHEGTLSAHSGTRNILSWVDDSEPRLIIEHVNAPLAVIEELLDANTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH60</accession>
    <name>A0A0N4UH60_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1477</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH60"/>
    <dbReference type="WBParaSite" id="DME_0000686301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000686301-mRNA-1"/>
        <property type="gene ID" value="DME_0000686301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000686301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13277" checksum="508CA1ACFD9B56BD" modified="2015-12-09" version="1">MGSRGGCDWEISELQYLFTWKKRLVVSSFSLSDCDNLLKLINCSNNWESSIVQRSRFFVIEKVVVSFWDSTNFGREFLEASSFVFLHQIAHNFLQIVDHIETNNGENCGDFLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHT8</accession>
    <name>A0A0N4UHT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 106B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9866</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHT8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHT8"/>
    <dbReference type="WBParaSite" id="DME_0000713601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000713601-mRNA-1"/>
        <property type="gene ID" value="DME_0000713601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="508875at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="8">
        <location>
            <begin position="117"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000713601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27319" checksum="4BBD5D84ED2E5967" modified="2015-12-09" version="1">MVKGQHSTSSTTNLIENSVESSNSSMRTLSNDYTELMAGSVPCPSCKGSGKIPKELEETLVALIPLNDERLKPKRTWIYVLSGVISCLFLAGGIIFLMVPRAVDLSSNRPPIELINVFSPATADYISFSFMNSLNISNANYYSVNIINSTSTIISKFQPWSSDVIGSGGNNTAVIIGAKTKNKSIFFNNTVTLKGDVATYCRAPFSRLLSLYVNMQFDISVTLEYLNHHEQATISMVQQVCCVPSGNCTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI62</accession>
    <name>A0A0N4UI62_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1697</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI62"/>
    <dbReference type="WBParaSite" id="DME_0000727901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000727901-mRNA-1"/>
        <property type="gene ID" value="DME_0000727901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000727901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22840" checksum="60E99C3226309BFB" modified="2015-12-09" version="1">MVSRTTPRAEFSLIRTYPAVPYFHKSVDSREAKIFAEMSSLKRVLDDIDDRDIAELTFKTGIGHMAAPFRPELLKVQQCLCPELGLLITRDSKRRRRTFDRLAISTRYLEKVWTVIAWLATSISILTFQADTALPRLQRTVPRNRFQSIVLACGHISFMNLGIVSRLDSALNACTNGLYHMRQRTQMPCQEHLSRVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ22</accession>
    <name>A0A0N4UJ22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1901</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ22"/>
    <dbReference type="WBParaSite" id="DME_0000763401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000763401-mRNA-1"/>
        <property type="gene ID" value="DME_0000763401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798700at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000763401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17492" checksum="50E54D165FDA080D" modified="2015-12-09" version="1">MITIPNCGGQNITEFYASSRRSSLYKTLRVRSQSISYTRDGRVLINGELLRKSIPNEKWGELIRGSIKFTVFEQYRLTSSLSEGNLHQAKYLVAGSFGQTELVESRLEKNIGRNSADQSGDKVADAQPKKQKKNAKVNEKNFSEQNRHENQTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ34</accession>
    <name>A0A0N4UJ34_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fanconi anemia group I protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1914</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ34"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ34"/>
    <dbReference type="WBParaSite" id="DME_0000764701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000764701-mRNA-1"/>
        <property type="gene ID" value="DME_0000764701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041161650" evidence="1">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000764701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38270" checksum="4BD23BCBCB82338D" modified="2015-12-09" version="1">MKLALSILVQILAELESRTSIEPIEPNEQTFFIDAMDIAAAANNLNIAERIEALYCSKVNKTHLASFVDEHKFYLRFLVLSMNNLSIEQLEKRYISLVPRIVGTTDFLFIEMLDLLLVEIFVKIPQNFSLHKNFYQVISQKKSNWSLTRRVIEDALASRMLTHFPIVARILKVLLSVDRNILSPDHFKEYTAIIEKIVKARLDYSQHPIKFKRLKFMPSEIINFTLLLIKAGQDEKGWDLLNLLVDSDVKDDDSCINKDIPGYITISTLRPLLKEILCRGDWFHACHCLQIMAEYIPQEPLEPHVEEVIQKCKLTSLQEKILRNFIKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJX1</accession>
    <name>A0A0N4UJX1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2110</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJX1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJX1"/>
    <dbReference type="WBParaSite" id="DME_0000798501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000798501-mRNA-1"/>
        <property type="gene ID" value="DME_0000798501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876197at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="503"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000798501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="669" mass="76016" checksum="A2C486FE749F819D" modified="2015-12-09" version="1">MFVAEKWRIPESLLLLQNFESESAWFSRAASKLSERFGNERPNNFFNDKSCKEEFDRILSSSHPEHFLRKKGEKYSQKELVKAWIDFMQKQLREDLVREGELLLIKLREKANLFNRLFADDCSMTEEEIKRLLDQAREEDSKRDQEIVRHEVEIGTKRIQEIQQLHKDDPKKHPPPRIHIPPSRPIENETGNPLSPIKSLFEGLNSSLRSSAQSAQSSASPISSDDLGIIDKEPRGRRRNSRAVNGSGADIVANLQPDTSAHSSRISDEASLSILQCDQQSAKLDQVDEFPSVSVNDSSENDVMLSPFVKNEIKEEPFNMFKSQSIEMMDSSQVGEIQPFITKGRKRKTADINESRRKGEIRPKGRPAKRRRSNQRHGESDMSLVNSEDILESNIEVQSSPNSDSTNSFKISETKTRRETLRSSGNQEKGKVRTLRGKDDKESSTKSQDKRRISDRSNASKSSSKSDARNTQTHNRKYSKKSEADEIALEQKALMITAWRMISSHRHAAIFAHPVSDRDARGYSIAVKSRMDLGTLKKQLDTGDVHDMLEFKRRILLMFANAVMFNSTGHDVNIYSKEMANDSIKSLKRLAKDVLYVKGGAHITRRSAAFAAEEALLERRKFVGPRTSNVGSVDDDYIRDKEADDSIRSDDSNILKTSAAKSMKKLNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK11</accession>
    <name>A0A0N4UK11_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK11"/>
    <dbReference type="WBParaSite" id="DME_0000803001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000803001-mRNA-1"/>
        <property type="gene ID" value="DME_0000803001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805034at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000803001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17957" checksum="663B7147C0DF6A44" modified="2015-12-09" version="1">MGTVLEARDPTDFIPKDIQLHKFTKMIGMINIPSDVVSEFYAEPERSSDRAVFRKFSANKCTVQPISTSNDNLVSQCQRQQSKSTDSLWHDTLQQSVLLKMAKETIKKSVSCDSLNSVTNPLDDHCELSNERCPQAANCGWCPVLVLISISNTYAKPGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW3</accession>
    <name>A0A0N4UKW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2405</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW3"/>
    <dbReference type="WBParaSite" id="DME_0000839901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000839901-mRNA-1"/>
        <property type="gene ID" value="DME_0000839901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962185at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000839901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25470" checksum="F58AB1FC94988059" modified="2015-12-09" version="1">MHSEIVILNDGLKFSNQAHRSFIISIHRKLLLQTGILNFRPPVNRSKSAPRLGSIDEEDELLENEGLAEEQRLINQLLIEALIFFSFQDDLSDIESLCYRKTPIGDEDCSNSVASTSSSCSPFSIQDSLNYHEEIVEANIDDGSSNNMVKLSKTACKIPSTELDVLPRKPNTYRKKIRKRLCSYQEDSISDESGYHDVSNSDGDLNLDDIESNDDEYEEQVTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKZ2</accession>
    <name>A0A0N4UKZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10379</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKZ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKZ2"/>
    <dbReference type="WBParaSite" id="DME_0000843501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000843501-mRNA-1"/>
        <property type="gene ID" value="DME_0000843501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000028">
        <property type="entry name" value="protein quaking isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000843501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29596" checksum="D7BCA61AA9102131" modified="2015-12-09" version="1">MEYLADLLKEKKQLGVFPQVFRHIERLVEEEIGRVRMALFQCHFAIEHRDLPEPEGEPITIQEKVYVPRKDHPDYNFVGRILGPRGMTAKQLERETGCKIMVRGRGSMRDRKREELNRGKPNWEHLEDELHVLIQCDDTPNRAYIKLQSAVDQIKKLLIPAPEGTDELKRKQLIELALINGTYRPINKYSMQTPRLLTPMTLVSPIRHPNGSITAPIFVSPTGSPITPGANASSTVSTFMQSPNLDYNLFMKLVNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL10</accession>
    <name>A0A0N4UL10_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2432</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000060">
        <property type="protein sequence ID" value="VDN52459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL10"/>
    <dbReference type="STRING" id="318479.A0A0N4UL10"/>
    <dbReference type="WBParaSite" id="DME_0000845701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000845701-mRNA-1"/>
        <property type="gene ID" value="DME_0000845701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19336">
        <property type="entry name" value="Wnt_Wnt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF101">
        <property type="entry name" value="PROTEIN WNT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000845701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38094" checksum="929EA08745260C6B" modified="2015-12-09" version="1">MKALSLSSSRIDRLHPRSSCRHLHGMNRKQMRFCRRNIEQMDSIRAGARIAYNECQFQFHTRRWNCTFINSTTNEVYGDFILREGTREAAFVHAISAAGVAYRVTRDCSKGLIDKCGCDQSVLHKRDDQFSWNGCSDNVRYGIAVSRAFVDSSEKGRNQTMQRRIMNLHNNNAGRQVLESNMRKECKCHGLSGSCDMKTCWESMPTFREVGLIIKDKFDGATEVDIIDEENKLVMNRKNVQFKRHTKADLVYLDPSPNYCEPDPESGVLGTHGRLCNVSSYGIDGCELLCCYRGYEIHVRKITDRCNCKFYYCCRVECEQCTKIVEDNICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULB1</accession>
    <name>A0A0N4ULB1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10426</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001217">
        <property type="protein sequence ID" value="VDN60453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULB1"/>
    <dbReference type="STRING" id="318479.A0A0N4ULB1"/>
    <dbReference type="WBParaSite" id="DME_0000857901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000857901-mRNA-1"/>
        <property type="gene ID" value="DME_0000857901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912041at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="110"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000857901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27695" checksum="8F06B04245CF23D6" modified="2015-12-09" version="1">MENCKYKCIVITNQSRYLSAGAIVFHNRNINFTTLPLNRHSNQLYVFLNAESPIYTLKMPDEMNDNYFNISMTYRKDSDIPISYGVMSRISNTTPPDKIWSWDQVIKVVNNKTKSVLQLVSHCSSNSARHLYTDTLKNFINVTVFGHCNQNPCDEECEEMALKEHRFYLAFENSVCRDYVTEKAFHSMNNLLIPIVLKGSLCKNILPEGSFIAIDHFNSPKELAQYLKYLESNKTAYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULK1</accession>
    <name>A0A0N4ULK1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2594</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULK1"/>
    <dbReference type="WBParaSite" id="DME_0000867901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000867901-mRNA-1"/>
        <property type="gene ID" value="DME_0000867901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000867901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18215" checksum="6FBE259FC527EE81" modified="2015-12-09" version="1">MYTPMAWDEESEVASETEPSSVAASNLPLTTQSTTFNTFLDKPSRNSINVLNKKDAVSSHQQMTVDIMSAAEGSNQSTTSGTCSTTASNQISSLSEFSSDTINGQHNAPSNQPALTYLASNCSSSNLREMRDNGRLTNGGEKHNAVSYIFNESAGNLIINDFCLADLINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULP4</accession>
    <name>A0A0N4ULP4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10460</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULP4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULP4"/>
    <dbReference type="WBParaSite" id="DME_0000872701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000872701-mRNA-1"/>
        <property type="gene ID" value="DME_0000872701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="155"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000872701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="739" mass="85231" checksum="33CE9000639A8975" modified="2015-12-09" version="1">FDPDIIVGYNTQRYSWSYLVERAANAGRNLLSELSRYRVALSDYFCDERQLIIRDLFPRGRILINIWRILRSELPLSFYNLRSYCLSNVIHHVLGRRFPMYSFQILTQWILSYDCYLSDLFIRHFLTRTCLNLSLLCHLNFFTRTAEMARVYGIQFIEVLSRGSQFRVESMLLRLARIQNFVAASVSPAQRDSMCATETLPLTMEPQSGLYRDPVIVLDFQSLYPSIIIAYNYCFTTCLGKFSSIKNCFQNRSNQSSERIILGGLPYFLPVDELKLMLTRNEIHISPVGGIFCKKSVRRGLLPIMLEEVLNTRIMVKKACKTYCNDKYLSRILHARQLILKLISNVTYGYSAANWSGRMPCVEVADAIVSKGREALERAISTVNNGNYCGARVIYGDTDSIFVLCPGATREKAFEIGEKIAADVTNSNPTPIKLKLEKIMHPLILETKKRYVGMSFEKSTDEEGVFDAKGIETVRRDSCPFVSRVLEKALRLLFANNMGAMVRYLDMEFSNLDKLNISDFVFAREYHHHYSPNAVVAAKRIAEKRKAICLRYEPEAGERVPYVIIAGPPKSSVISCVRELQDFLSNKHLLLNYEYYMQRHMLPALNRMLQHVPMRLEWRMSSVNVCLSCRALGAFPWCTQCIRRPEALLPTVLDLCREQRKSAIMDRLCRQCNGTDNLFIILLSIGLRSVDIEYSNCKNMTCLVMQKRVKMKRSHLVEAVCQHICSSESEYLKFYEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM55</accession>
    <name>A0A0N4UM55_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2756</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM55"/>
    <dbReference type="WBParaSite" id="DME_0000891001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000891001-mRNA-1"/>
        <property type="gene ID" value="DME_0000891001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000891001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11739" checksum="0B6A0C33963129CB" modified="2015-12-09" version="1">MSTIKFQIQDTLTVLCKNVEKGHKVLLNVRKYDELISQLREAYQGDLKEVREDKSMNELKSTQRLRQIMDSTTSWEKGKRHTKNFLTILLSKNRSARQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMM6</accession>
    <name>A0A0N4UMM6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10614</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001229">
        <property type="protein sequence ID" value="VDN60641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMM6"/>
    <dbReference type="STRING" id="318479.A0A0N4UMM6"/>
    <dbReference type="WBParaSite" id="DME_0000911001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000911001-mRNA-1"/>
        <property type="gene ID" value="DME_0000911001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844158at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033761487" evidence="3">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000911001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25241" checksum="D43C3D18C55CDF90" modified="2015-12-09" version="1">MLFTIIAYDLFVFISFANSSAHEYRLLQDLRENYDYFERPVKNSSTALPIKVRLFLNQILDVNWTDYKLIWDPKHYGGISDVRFSGHSTAPIRIWKPDVLLFNSVAETFDSTFSSNFIVKHTGEVIQNPPGILKFGCAIDITWFPFDDQICFLKFGSWTYSGEFIDLDMDLTGMNEGINDTEYSSIPFRDKDDPDSYFVFDSIDRTFYIDNGEWSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMY0</accession>
    <name>A0A0N4UMY0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2972</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000093">
        <property type="protein sequence ID" value="VDN52999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMY0"/>
    <dbReference type="STRING" id="318479.A0A0N4UMY0"/>
    <dbReference type="WBParaSite" id="DME_0000923501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000923501-mRNA-1"/>
        <property type="gene ID" value="DME_0000923501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF3">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="174"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000923501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44463" checksum="727FA65A691E4263" modified="2015-12-09" version="1">MTADLMNSDFRLFKIEIDKNEYPTHDNMPITGHIKIELKKPLIIKAIKIQFKGRALHRENGNESEKAYVDNDFNLLDRIPGQPVPASFPWNANFLYSLPFNFIFPAMCPTSYESPQGYIRYWLRCTVVLDDAQKTEYMIKKGLNVVAWRATSSADHPSNSISASETISFGTCCCRGKLSAEVQLPKSNYSPGEVVYGSLKINNRHPRHMIELVDVKLVDSLTRANSPFAYPGRTLVHQKLDLNNLKPKGVTQKDDIAFIKIPAVAPTTIQGSSDSMMTGLFFSSYINEESNNVGTMHSNSFAFRKQPFLQIHYEIQVVISGKLELRLPITIAALQTQGSRIVYKPFVGGPQNIIERDEMDKKRLNNFEFTPYYPYLNEITSTIGGIGSDGINSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN21</accession>
    <name>A0A0N4UN21_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyanocobalamin reductase (cyanide-eliminating)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3006</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MMACHC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000096">
        <property type="protein sequence ID" value="VDN53033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN21"/>
    <dbReference type="STRING" id="318479.A0A0N4UN21"/>
    <dbReference type="WBParaSite" id="DME_0000928401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000928401-mRNA-1"/>
        <property type="gene ID" value="DME_0000928401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033787">
        <property type="term" value="F:cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12959">
        <property type="entry name" value="MMACHC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032037">
        <property type="entry name" value="MMACHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457:SF2">
        <property type="entry name" value="CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457">
        <property type="entry name" value="METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16690">
        <property type="entry name" value="MMACHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000928401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33879" checksum="50099F3D7C4BFE07" modified="2015-12-09" version="1">MFRYSRTKFRLLTNVQLLLSIRNYLCEKYPSVLKQLNMNEDSRKISNILQESLKESDGFEWYPFKVVSYNSNVAENIRLDFDSDSLAVIVLSTPLYFEKTLKSWLQQLYSQGDCLQDLIIRVKRNPITHYFNLKFSNIEKLVSPYKMWWTSDYEPVIHRPPKVSLPAAGHVAGAAYFYPPNTGGNTEKRRMGLSLHPQYGGHFSFRGVLVFPDIKLSSDFREMSAPKLLESDEEIIRVIDLLNHHYIDNRYRDFGNPKQKYSDLQLKYFNTDPRKRWQLIAHWFEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN48</accession>
    <name>A0A0N4UN48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3035</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000098">
        <property type="protein sequence ID" value="VDN53062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN48"/>
    <dbReference type="STRING" id="318479.A0A0N4UN48"/>
    <dbReference type="WBParaSite" id="DME_0000931301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000931301-mRNA-1"/>
        <property type="gene ID" value="DME_0000931301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300:SF1">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000931301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="61104" checksum="5F0285C9ED62FB43" modified="2015-12-09" version="1">MSKNCNGLVASTSTAQMHERSPSKTPSKNQSSIKGKNSQVVINQLSPFLTTKRCKNRPRKALYDVFLGGSCGNTVWRRDQVIPYLEKRAISYYDPQRSVWNEHMINEESVAKENSSLFLFVLDPATVNATSFLEIAHFAARKAPKLVVVFLGQSEWRDKGHPDDLPDRQRTCDLLDNILTTHNVPVLQSIQEALRYIDEVIIGEKTWSEAMSNPLQRLPYLMLCGRRTFKHLVKKIKTTWLLIKNIIARWRGTKYVLIGICEILLILTIHCFLHGLPILLILIPVIALDVILAITSFIYYRQKADETAKHHAKLLQQRINSFHLPISSHSSVPFNVIPQQLPLTYSSQNNSGRICDETTTLPNNFLKYCAISHKECFNQLTWRNGFDVFLGCSSRNNAELSWIPQVAAPLLYKKGISFCSDLMVEKNKRLVTLDISRRILYHIPSCETILSGMVEVAYFLGHTNWSLVLCVPKRAKMLISPTSNDEIRRHIDQRNECYRMAFCYLRDMAERRQCEVFSHLDDALQFVISCSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNM6</accession>
    <name>A0A0N4UNM6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Osteoclast-stimulating factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3195</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNM6"/>
    <dbReference type="STRING" id="318479.A0A0N4UNM6"/>
    <dbReference type="WBParaSite" id="DME_0000950901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000950901-mRNA-1"/>
        <property type="gene ID" value="DME_0000950901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF10">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000950901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23938" checksum="3B3216E6CB17971D" modified="2015-12-09" version="1">MNTKLAPKPAPKPGRVTVYRAVSDYCDREMSFNEGDLLYVSEDTNNTESAEWLQARCGTYIGLVPRNCVMNAEYVDFPLHDAAKRGNIEFVKECIKNSVSVNSLDKSGSTALYWASHGGHTNIVEMLVTVPNICISAQNKLGDTALHAAAWKGYADCVRLLLNNGASTNLKNNDRKRPIDVARNVDCYALIQLAMRGTVHPEDSNDYLSDSETENSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP47</accession>
    <name>A0A0N4UP47_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgi phosphoprotein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3331</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000124">
        <property type="protein sequence ID" value="VDN53358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP47"/>
    <dbReference type="STRING" id="318479.A0A0N4UP47"/>
    <dbReference type="WBParaSite" id="DME_0000971501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000971501-mRNA-1"/>
        <property type="gene ID" value="DME_0000971501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000971501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28224" checksum="6D84F7E14DBF1A75" modified="2015-12-09" version="1">MSDGLVQRRRNPASTTKFVEGYTSFWNDCISSGLRGCILIELALRNRIELEKVGMRKRGLLSRKVLLKSEQPTGDVILDEALKHIRETKPPETITSWIEYLSGETWNPLKLRYQLRNVRERLAKNLVEKGVLTTEKQNFLIFDMTTHPLHDGNTKQKLIKQLQEAVLSRWTNDVQRMDKRMLSLVILAHASDVLENAFAPLSDQDYEVAMKRARFLLELDFANESNKKGNASNDVMWGVFEAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ50</accession>
    <name>A0A0N4UQ50_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3648</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01000162">
        <property type="protein sequence ID" value="VDN53675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ50"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ50"/>
    <dbReference type="WBParaSite" id="DME_0001011801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001011801-mRNA-1"/>
        <property type="gene ID" value="DME_0001011801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912041at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="118"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0001011801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="28099" checksum="F310528D0BA896C5" modified="2015-12-09" version="1">MNSKIAYAMQFCSHKCDIIESRKDILKAGAVLFNVNDLRLNNLPKRRIPNQVYVLLNRESPHHTYIYSKRLPPYFFNLSMTYRLDSDFYYGYGRLKKITMSTDPSKIRNWKDIKKIVKKKKKSILQFVSHCYTPSKREDYVDELKRYINVTIFGKCTSNPSEHRFYLSFENSVCRDYITEKLFTRIDQLLIPIVLKKSFYRHILPDDSYIAADDFSSPKTLADYLSAVENNITEYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQR8</accession>
    <name>A0A0N4UQR8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3843</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000199">
        <property type="protein sequence ID" value="VDN53870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQR8"/>
    <dbReference type="WBParaSite" id="DME_0001037301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001037301-mRNA-1"/>
        <property type="gene ID" value="DME_0001037301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001037301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8342" checksum="665A0BBBAE881306" modified="2015-12-09" version="1">MQIRSISIKLLILIKNIERMAKGKEVTADKSRPEKVTDSPGTLIKTNGSNPGGSREVPRPRETERPQPTEAEAANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR88</accession>
    <name>A0A0N4UR88_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3991</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000240">
        <property type="protein sequence ID" value="VDN54018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR88"/>
    <dbReference type="WBParaSite" id="DME_0001056101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001056101-mRNA-1"/>
        <property type="gene ID" value="DME_0001056101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001056101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8491" checksum="091B9AAE2DADCA61" modified="2015-12-09" version="1">MKTTLRAVIGKQTMEDESFRTIIYEIGRSCARKTQILLQQQPPWILQAEDIHKELELTRMYAEKIYCGTGQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URE7</accession>
    <name>A0A0N4URE7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4047</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000260">
        <property type="protein sequence ID" value="VDN54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URE7"/>
    <dbReference type="WBParaSite" id="DME_0001062601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062601-mRNA-1"/>
        <property type="gene ID" value="DME_0001062601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041159745" evidence="2">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="3">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="3">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="3">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47609" checksum="1C41089CAD0D35AD" modified="2015-12-09" version="1">MIIPAIALALLWCLGQSCARIYDPLCVQTGRKCGHNMVYRTVDKMKYTDDVSPELICIQECTCISEQYERKDGQCIEKNDILTRNEVPIENLFKEIETTTTTSTQRFVTKEFSAQITAQKSLPKVPTSKACSGRICALDEIITDILCSLTDQKCGPNMAFKTIVGPLYMKVGISSYKICIQQCICDSNEYTKMGGQCIKKSSAPMRNETEFAGEILPKHCAGRVCALDEEIYKVPCSLTGEVCGTNMIFNNIGKLLKKNGTVVCFQKCTCVSEEYVKANGQCILSTKGNETATPTSTQRSAKGNESVAPTATKRSGTEHPQFPIKPTIQQHPETRAKCVGRSCEQIRDPFCKLAGRKCGDNMVYKTIERLIRIDDTPEMCIQQCKCVSKKYTEKGGRCIIRERSVKKNHAQVTLYCTIIILKFAKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URE9</accession>
    <name>A0A0N4URE9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4049</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000261">
        <property type="protein sequence ID" value="VDN54076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URE9"/>
    <dbReference type="WBParaSite" id="DME_0001062801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062801-mRNA-1"/>
        <property type="gene ID" value="DME_0001062801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720486" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8763" checksum="A857818CD4605954" modified="2015-12-09" version="1">MYFFYLPLLFFISCINAGDMPINVCNMAVQPPPAQPPQPPAAVQRPTVDPNLCADLDPPACSAIFTLEQAGDTLRDQLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URL5</accession>
    <name>A0A0N4URL5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4108</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000299">
        <property type="protein sequence ID" value="VDN54135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URL5"/>
    <dbReference type="WBParaSite" id="DME_0001069701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001069701-mRNA-1"/>
        <property type="gene ID" value="DME_0001069701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001069701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14388" checksum="D909B010D7121366" modified="2015-12-09" version="1">MIANNLCENFLKISQVKGFGKFFLNSVIRGKEYAASFADKYRSSAGITKRRIARLPRIIEAIFHAELNEKYVMKKEKLYDNGFPVWKSSNKTVVDIAPNRFNYKMKAYAEETGSPYCSAVFLVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URP5</accession>
    <name>A0A0N4URP5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed DNA polymerase, eukaryota, reverse transcriptase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000317">
        <property type="protein sequence ID" value="VDN54157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URP5"/>
    <dbReference type="WBParaSite" id="DME_0001072701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001072701-mRNA-1"/>
        <property type="gene ID" value="DME_0001072701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412006at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001072701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11147" checksum="93BB56D4FCCF4D35" modified="2015-12-09" version="1">MVRDSKGVLIKSIKDRLIKWKKFFDAKLNHGAPSVASDIADTFAEAYACNCEPTEEEIISVIHKLKVNKTPGKDGLQAELFKYCPSSFITHLQQMYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US43</accession>
    <name>A0A0N4US43_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4269</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000545">
        <property type="protein sequence ID" value="VDN54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US43"/>
    <dbReference type="WBParaSite" id="DME_0001087501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001087501-mRNA-1"/>
        <property type="gene ID" value="DME_0001087501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804200at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001087501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26517" checksum="7F920D84691904D8" modified="2015-12-09" version="1">MHKQTGLFLLKAFGLRYEQLLVLSNVEIEECVKLVGNDHKKRPTVDFCPEDPACSSIFPYDLQTEPNVLANNLRENEHYKIPELCNKVKDFAAKTCPRTCAMCCKTKEFNCHDVNPDACRRLDRNICLTVPSVALSMCPFTCGLCHRPGAAGMCPDENENCAAIFHLDPTCSTDFMKRSCKKTCRLTDCLPGNSTSNSSTCTDLHPQCQANARYCNIGDYAVVMSRVCRLTCRHCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US94</accession>
    <name>A0A0N4US94_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4316</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000713">
        <property type="protein sequence ID" value="VDN54343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US94"/>
    <dbReference type="WBParaSite" id="DME_0001092601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001092601-mRNA-1"/>
        <property type="gene ID" value="DME_0001092601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001092601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19399" checksum="D0FE735A005E6B33" modified="2015-12-09" version="1">MVQRFYISDKNYDQKTIVKSENVEFSTLMKEDWKKTKNFGCAKKLCFNKFSRIDLTICFYKLREAPANSRYAMKSSSGQNLPLQLKYDLENATFSSEQEPSTNTSTQNNTVEMSTLDVNSSASQFESFDSDSSESESVEIETVSTYQPTTMETVSTHETTRLADTMQASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2R0</accession>
    <name>A0A158Q2R0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GMP_PDE_delta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5007</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2R0"/>
    <dbReference type="STRING" id="318479.A0A158Q2R0"/>
    <dbReference type="WBParaSite" id="DME_0000064701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000064701-mRNA-1"/>
        <property type="gene ID" value="DME_0000064701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000004">
        <property type="entry name" value="protein unc-119 homolog A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF1">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="5">
        <location>
            <begin position="52"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000064701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25603" checksum="BC9B3F3E8E7B3C79" modified="2016-06-08" version="1">MPQIHRGSSSTMTENCIHEPLSEEELRSLSVITPEDVLRLDKITDDYLCKPEANIFDIEFTRFKIRDLETDQVLFEIAKPTNEYEDNEYPVASVQLAIDEASATRFVRYQFTPAFLRLKRVGATVEFNVGNQPVNKFRMIERHFFRDRLLKSFDFEFGFCVPNSRNTCEHIYDFPQLSETLINEMIACPYETRSDSFYFVEDRLIMHNKADYAYNGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q369</accession>
    <name>A0A158Q369_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLD phosphodiesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6150</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q369"/>
    <dbReference type="STRING" id="318479.A0A158Q369"/>
    <dbReference type="WBParaSite" id="DME_0000179001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000179001-mRNA-1"/>
        <property type="gene ID" value="DME_0000179001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000179001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56779" checksum="EC32A66FF1C62302" modified="2016-06-08" version="1">MNSVLRSVLSLKGCKSLLEAANSVTCNTTQDGRADMTNFEMDLFDARMNSYSVEKEESEQCCKHTIIKPACIPISIISLFIFMIVFFPLFNEDSADATLSRYERSGFCMDQCSLGIVESIPTNLTYPNFTQTMSTYEAWKSLLDNAAFSIDLAVFYWNLRDNFRHPTAWQGQDIFDRIVLAAKRGIRIRIAQNMPSHISNGSDSEFLASNGYASVRTLNFSSLLGAGVLHTKFWIVDARHVYIGSANMDWKSLTEVKELGYLISNCTCIAHEFSKIFAVYRRLGVNDAKIPKKWPINLRTFFNFSHPLDNSPPRFNTKGRESDDISIVKAMEDAKEFIHVSVMDYLPTTLYMGKRKNFYWPMFDDAIKSAAYRGITVRLLVGNWSHSKPAMIPFLRSLTVVNQALPRRFNSSGKIEVKLFTIPSNEEQRKIPFTRVNHNKFMVTDRIAYVGTSNWAGDYFINTAGVGAAIILPSVVESLNRIFCRDWYSQYAVDLEHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3F7</accession>
    <name>A0A158Q3F7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centrosomal protein of 135 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6671</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3F7"/>
    <dbReference type="STRING" id="318479.A0A158Q3F7"/>
    <dbReference type="WBParaSite" id="DME_0000231101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000231101-mRNA-1"/>
        <property type="gene ID" value="DME_0000231101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864070at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="938"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000231101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1634" mass="192526" checksum="3E5D694312B8C67A" modified="2016-06-08" version="1">MSHFGGMDSAKLEQLEALLNVDVENQEFIKNCYECVIKYEYNADDPPQTIRIIIQSMKWLLEYERAFADELREIAEKEANEFNEKEDKLEKEARTLKNEITELRKLLASNTKNDVYKSETFRVDNLQEEIAYLNAQIRGRVREINDERDKNEELTARVNALEKERNSLIHHKSLLEDRIRDLNRHLSSTNEISAKIEADERKLNQRNEQIIKLSSHIKEITQRNDEMANEIDRLSQALASATVFIEDTTEKYASMRNELIESNKVIERLANENEILTKQIEVRGEAFKKMEYTEGATIECYQVSFFVLIFEFSEIGTRSIVKIYFSIYGIVLKNIISGKDRQIEELQEATRSFQVELDKTRAQIQLNKSEEREEELERLRNELVEATKFAKQFFGSINAGRDRNIMELQSKILQLNQETFGDAENEISRLEKQLKFRDEQIEKLNVKCSLLHYELISPSEKANTSFSGVLNLSHETIRSAEESSEDSTSLSPPKLKTTEDKSIETDVKNTVDTVQKALATEKTEIQTKILRPNTQTIESWEASAMLIASQNHELMILLQEIEDKDEQLQRMERIMIDATKNFDCLTEKYSKLQEEFIKFKEVKERELNRKINDTIAEYEVELEWYNKLSNSVEKGELTKATMHRKLISERIQRCRLDRKLRMIEKNYESEKDKNINLKKKLQYNIMLHGKQLITARYEAELTTLELARLQNILLHSVPQREYDILLDKYKRILVEESGDIQPSQLRSSCNLQIELLQTDCKSNENELLAKIDYLKNLNDVLNNQNEFWKAENDKLIKENGELQKFFEEIECESHVKGMLVAIQRRFLKLLTEQADYNRSQTFSANQFHRLRSEFSTKSLQWVAERKKLIKIIRNLQISIQVNLPRFYAFSGRVESKSEELAIQLRNIESIKWSHEKIKENDFDVIKLQKSFQANQFNLLNTINDLDNTKSQLKKKEEKIAELETYIEQLKIQISDLITADSDIISFNVDNAKALAEENIVSDITNPGDLEENAITTQQVPSATINSSEAEAEQKECLQTKMIIYDNSEKCEKKVEYIRETAQLCIENYKDQLKYKEEVIEKYKEIIKQMDNKKISEKNKGILLQRENDDEGKLTEKMKRSNEILENQKFDENFQQIYRLKMDIDELENANKRLSERLTEINETSQRNQQQQQVQQLKEYIDGSTQTINLDEIFNDEKIINENYQSPLSPSPSSFNKPSLSPSPFNKFDEQNNRIIDLNENQSLKIPQELNKLTKKKLQIKTNDGIRNENNILHALRKEESLVNSLRNEIRTLKERLATQTANNKELKEVCEKIREEALSTIEQKYYRTEFATGNMENNELFNKLEKTKTEVINLKRTVRIQNELIGKLQKEQKKFELKNSSECESRESELQEIIKRREKRIEQMNREEKLRINELEKLEITLKDLRMNNDNFLSIKDESDKKIKMFEDSISLITQQNTLLRKENEILNGRLTNLQNELEDANEKLQRIREEKSQKIENLHKFSKSTEINGIEESLFQKNSRDTYGNTEYSEMRPNQAGFGSGPGCADQIFTLRRYKEAYEEARERLLLVEKEYTKFRKEYNKIIKRITKKEFKEPEEISAIAVLRDKLMAKEKIIEQQNHRIEMLERERWRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3S0</accession>
    <name>A0A158Q3S0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-mann_mid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7201</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3S0"/>
    <dbReference type="STRING" id="318479.A0A158Q3S0"/>
    <dbReference type="WBParaSite" id="DME_0000304201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000304201-mRNA-1"/>
        <property type="gene ID" value="DME_0000304201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="4">
        <location>
            <begin position="470"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000304201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="600" mass="70068" checksum="EEF5756CAD61BF85" modified="2016-06-08" version="1">MKKLYCKGRIMCDYVDPLTNTLLMKKWRLVLFLAFIASIVIFLLQLSIISGDEYEIGKCTFFQKTKQFLVWLTTLTTSVKLFRSIFHCYVFAPFIRKNSRYSRTETHVELCPLVNLSNDYSIDVVSGHKVKLNITNSNNKAPEFLNVFVILHSHVDPGWLKTFNNYYYHKVEKIIDNAVESLMKFPQLKFIWSEISFLEKWWSRQKRIAQNHLLKLVRERRFEISGGSWVMTDEATPYFWATIDNMITGHQYLLQTFNVTVNTAWSVDPFGHSAMMPYLFSLSGINRMVINRISTLIKDIMKQKSQLHFRWVQPWDEEIKWAPLVNVLPRLYYTTINACGPDEKICCQFDVAPTARTFCERRATSDASTLEEFSTLMADQYRKLQPYYNSKSVLVAAGDDFLFAGEKDLPTVHKVYSALFKYINEHPKFNMKVQFATINDYFNSLEGSRIFPLLKGDFFPYVDNINGSYPFWTGFFAHRPYHKRLERIVLGRLRSMDILSAITKLEPSVNSEKARRDFALFQHHDAITGTSKPHVMKDFTSRLFLRIFNQNSFSYSHLITVKVSTPNIRVAYEGIPVKAQIGPCFDGIELKLSRKYFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q404</accession>
    <name>A0A158Q404_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7723</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q404"/>
    <dbReference type="STRING" id="318479.A0A158Q404"/>
    <dbReference type="WBParaSite" id="DME_0000371801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000371801-mRNA-1"/>
        <property type="gene ID" value="DME_0000371801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000371801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="505" mass="60178" checksum="BEFBF9302D2B201C" modified="2016-06-08" version="1">MSLIITEMDKKLSDDHEEIEENEYKKMTAENSHLTRYQTLLRNHLSNLNDQLELQIKDQRLLIKENNQSIEEKQQKLENIKRECKKFSVKNNVKSVEIDEKQIERQQLMENIVSINKRMENDDREFKSNEKKEIELRELLSKINISIGDAFSINHELNRNEENNVKVTKRIFSQSQHQFNSMNNEKLLQTNYINRLKRDVKAAEAELSTTAKKLDRIERMIEEDSTALENQWKNLTRNQKRSEEKIRFNESSALKEKENIKLLKRKGKQLDAEQIKIEHEIEEIERKNFFIHEIGIFSKKLDNFADLISRKKLIVEKFKKDLQSAEKKSANALKQEIISLKKKEEYISDNIKSLEAKLSAYNNNINESKQNIEQFANVVENLERNLQHIQEESVKLSEKYKTDRSTNELREKTKLERNSNIDLRQKINIDRQKAEKLRCELEVWKEKLEDLENGEKLAMFGQNDHRIIEIRQLKNYYSDIQKKIRNVQKDIIDTNAEYVKLRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4D4</accession>
    <name>A0A158Q4D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SOSS complex subunit B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8498</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4D4"/>
    <dbReference type="STRING" id="318479.A0A158Q4D4"/>
    <dbReference type="WBParaSite" id="DME_0000461501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000461501-mRNA-1"/>
        <property type="gene ID" value="DME_0000461501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000461501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22146" checksum="2778A4E34FE181FE" modified="2016-06-08" version="1">MSAEMNRPMVIAQLGPLMKNINLSFIVIDIVMAVLGHSRRTPQGHDVRTVRVADATGSISMGVWDELGGCISTGDIWRLRNGYTTVYKGTLNLSCGKLGDLQKTGEFFMLYSELPNMSEFSAELAAKYPTLRKGSPDEDVNNGQSGNNGSSAQNAPSGNSSATQKSQQSSTQRPIKRTGSLSISHTQITRRVDLPFPKNPRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4P1</accession>
    <name>A0A158Q4P1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="6">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DME_LOCUS9112</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24 26" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4P1"/>
    <dbReference type="STRING" id="318479.A0A158Q4P1"/>
    <dbReference type="WBParaSite" id="DME_0000531301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000531301-mRNA-1"/>
        <property type="gene ID" value="DME_0000531301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000032">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="23">
        <location>
            <begin position="267"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="585"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="VDN59139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="DME_0000531301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="743" mass="84416" checksum="90B642C9044F7357" modified="2016-06-08" version="1">MLSGCALASEELDDLFFKYGLELDEIVHENLEIQKGNQRKSVEEEIYKIELPANRYDLLSIEGLSRAILIFNQQLNPPKYSLSNAEQKERIIILPETAAVRPFIVGAILRNVTLDSDAYASFLDLQDKLHQNICRKRTLVAIGTHDYDTIKGPFKYGAEIPSEIRFQPLGQTKEYTAEELMILYSNSTLFQNDSHLKPYLRIISNKKHYPIIRDSRGIVLSMPPIINGEHSRITLNTKNIFIEATATDLEKAIIVLDTIVALFSQYCKVPFQLVYIRNINKRIGVCMNYDEIMAYLSRMSISCRKLAEEYKLEVTVPPTRHDILHECDIAEDIAIAYGYNNIQQQLPNINTIAEPFPLNKLSDLIRFEIAAAGWTETLNFALCSGDDISSKLRRIEELNEAVKISNPKNSEFQVARTSLLPGLLKTIASNKDMPLPLQLFELQDVVLKCSLSDVGARNERRLAAVYYNKTSGFETIHGLLDRLMLSLAIKWSKDGTGYYISAHDNPTFLPGRCAKVIGPKNITLGTLGVLHPDVIVSFGLNKPLSAFEINIEPQGMYADCLLIIFIATFTALFGELLTYLLVYRSDQYKRLKNEMERKTKKLERRKEITVEADRNAKRKIEREEEKLKATNRDMNIFKMKSMLAIGFAFTALLSTFSSIFDGKIVAKLPFTPISWLQGLSHRNLMGDDYTDCSFIFLYILCTMSIRQNLQKLLGFAPSRAMNRQAQPNFFGASTASTNFSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q503</accession>
    <name>A0A158Q503_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9458</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q503"/>
    <dbReference type="STRING" id="318479.A0A158Q503"/>
    <dbReference type="WBParaSite" id="DME_0000616201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616201-mRNA-1"/>
        <property type="gene ID" value="DME_0000616201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38785" checksum="E10936A4AD782730" modified="2016-06-08" version="1">MTDSNKRFKTSKKVLNAGKGTLPEYRAGTKAIFHYEALCPRNDANIEGFPESRDCFESIDDTRKPYPDGYGRPMELVFGKKFQLPVFEMCLQTMLVDEVSELYSYPHVSKTLRDISKNAGNEMKNKEHHHSHCGAMFAIDTGYPALNELAKTPKSLRFIFHLIDVLQPESYEPEGWQLNPVEKMASISRLRQSGNEFFKKGDFYSASSNYREALGRIDTLLLREKPGDAEWVEIDQQNIPLYLNLSQCFINMKQYYEAIEAASEVLKRDEINEKALFRRAKARIAVWDLEKAEDDLKRLLKVKPELANLVDAEMVIIRKLAQERTKSDKSVYKNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PX58</accession>
    <name>A0A3P7PX58_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PX58"/>
    <dbReference type="STRING" id="318479.A0A3P7PX58"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="83" mass="9409" checksum="5A3F4EB8073B82C8" modified="2019-02-13" version="1">MYRKKQGKVPRCGDTGVKLKGIKPARPRQLSKMTRRLKKVTRAYGGCLSAAAVKERIIRAFLIEEQKIVARVLKATKNIETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXT6</accession>
    <name>A0A3P7PXT6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXT6"/>
    <dbReference type="STRING" id="318479.A0A3P7PXT6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65356" checksum="418BDFC2C7C3009A" modified="2019-02-13" version="1">MRDATWKDLRSIFALAYPYKGRIFLGLLFLGISSTIFLFVPRVLGQLIDELNEDQTKKVRIDDFTLKLAKYFKAHPLALIGVFFIGAAAICGRTYCMHTAGQLVINDLRAKVFKSILCQDMGFFNKNKVGEIVSRLSTDAFIVGNSVSMNLTEGARALVTCAGSAALLIYTSPQLCKVTTFVIPLIVGSFAIFGKLQRKYTVQMQQAVADANQVATERLSNINTVRMLVAESREFDSYKKKIYELWLVSRREGLARGIMFGGYQFTGYLALLIVVYYGSMLISQGLLTYGELSSFALYAILCAASIANTSVFYTELMKGLGASSRLFELRNRIPAIPLSGGVKKEGITKGIYFKQVGFAYPDRPKIFHDLSFHIPAGKVTAVVGPSGSGKSTIAFLLLRLYDPTDGCIMIDDTPLKEIDPSFWRRQIGTVGQEPVLFSTSLRDNIVYIQEVTIQSNAIEFINEFPDGLQTMVGEQGATMLSGGQKQRIAIARALINNPCMLILDEATSALDATSEYIVRLALYKLLENSKQTVLIIAHRLSTIKYADQIAVLDKGSIKECGTYDELMAIENGVFKKLIEKQAIGWREDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q159</accession>
    <name>A0A3P7Q159_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q159"/>
    <dbReference type="STRING" id="318479.A0A3P7Q159"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="649" mass="74621" checksum="2EEC0DBC94FB8E0B" modified="2019-02-13" version="1">MIGYALYNPSFQEDIKKYIPQSQQLFDKINQWIPAEREEKRGISFGEYFGNVSSGVKNWISNGKKTSEKEGNSFLKIPSLPPLANSKKVSADVEPVDIRKVPKEINVNESFQANERLNERLSRNKELEEKLKSALSAATNKVHKASDAKFRTLPDWNKVIDAASKIELINQTDKAEEFSARNYIDNVRKIVGDAKQSETTQNNPLLIYASETVHKLNQQLDELNSLISQMHNESMLLSQYKDLIKKSRHEFAKELKKILPHIDTHAKDSKLTEDELNALIAHAHLRVNELKRQLAEQQAKFYHPYNFSYMMLSFSNYLLNFFQVQEERNIAKAIEQQRNLDIQLAEDQLTRKIKEIAEESDLKIEKKVAEDRLAWETELEDRLRRAAAAHSEHLEQVVRTQRQLFDIEHNQKIQEALSQERDLHGRQINVAHGRLEGIEAALKSRTAADLETRRTKHIWIACQNLVDSVIYGRRGGIDAEARKKPLASELQVIKEVSDGDDFVSCLLEALSNECIYEGVYTEDDLKARFRKVYKLCRRVSKIDENGGGLVRYLWSYLQNAVSLDLPQNFSDMDLIDPATIDTSEILARTKYFMDKNDLASAIRIAQLLKGEPENIAKGWIRDVRKHLEARLIAELLVTHATITNIRAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q625</accession>
    <name>A0A3P7Q625_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q625"/>
    <dbReference type="STRING" id="318479.A0A3P7Q625"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF9">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="259" mass="30390" checksum="D1BB8279A307D8FE" modified="2019-02-13" version="1">MQITEIFQLSPSTVFFIGFIPPVIGAFLSIAIAFLFYNDEISNYNWQCGRARFPSLSRIINLPLGRIIWQISILAHVPVRFIELFTGLSRYKRLLSVNYKYKKYYELYRYTYFYSGMIELLLLSGVSIIGERERLHVCLFYLYGLFSMIFFISNIKCHRQSLYYLNPYGRISYYAKITLCMGFLTTAPILFCAFMLYWKACITVAYDIFALCEYLEVAFTILYHGCAFFDIRYKVKFSVRVAEEIQSIEDSTISANLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q6W1</accession>
    <name>A0A3P7Q6W1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q6W1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q6W1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000070">
        <property type="entry name" value="Putative carboxypeptidase suro-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF51">
        <property type="entry name" value="CARBOXYPEPTIDASE SURO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018003226" evidence="5">
        <location>
            <begin position="19"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="7">
        <location>
            <begin position="69"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="499" mass="57752" checksum="A2469EA85A222F79" modified="2019-02-13" version="1">MVHHLFLFLLKFSRLIEQNEYGISKIKQNYTQLSWRGFLRMKDDPILDENPDTSSTKIGDMKVSYTFGDYASYKEMLKYMRTIEFYYPNLTKLIRIGRTHEKLPIEGLKIGYPVENNEKRAFWIDGNIHAREWASSHTALYFINQLISGYGRNSRITHFLDSLNIYIFPCLNPDGYEYSRSNPTPQVRLWRKNRSPETCKPSSWGGKRCCRGVDLNRNFDFHWAEAGSSSLPCSNLYHGEQVFSEPETRAVRDFMLSTRMRDKFDGFITLHTYAQLWIHPYSHEVDNYPPDYYDLRKIAKKAIEKLKKPYGIQYKIGTGANILSPASGGSDDWAKSKLNVKYVYLVELRPELELSNGFILNKKELIPTAYETWQAVQEVIDSTRSPSQDSTNHITKQPIVKQFNSQSMLTKSSSIMNGTWRISTISLPLSSLSLSSLTSPPPSSSTLSRITITKRVNSTCRDIRFSCKLWLKINRNVCIEQQSFMSIQCKKSCNFCKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q7H1</accession>
    <name>A0A3P7Q7H1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cuticlin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q7H1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q7H1"/>
    <dbReference type="OrthoDB" id="10068552at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF12">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cuticlin N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="231" mass="26808" checksum="DCB2FC52D99C89C0" modified="2019-02-13" version="1">MSAMCSPEEGITASIDFDQPFSGKIYSMEYSTVHECIYFNTVEMKSILFTIPIHRCGTRFTKNTRNVIDSMENRVYIQMDKDAQTGLDRQYSFMCQLVPTLESTSSVPWLQNAKANQIIFSDRHNWGNWPIYPLSAETKRQEMQKWEIEQKILEKSSSHADSPQQTSLSNADIFSERTVLDMQKWKEKVFIPTDKRPRVHKNQIANHVISSTIGKSAFNESIIPITRYIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QBC4</accession>
    <name>A0A3P7QBC4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MEIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000062">
        <property type="protein sequence ID" value="VDN52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QBC4"/>
    <dbReference type="STRING" id="318479.A0A3P7QBC4"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIS N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="201" mass="22015" checksum="D9CEE96209BEE836" modified="2019-02-13" version="1">MGYFGMAAYPTVGPPSGLLADPINEQMKRDKEAIYGHPLFPLLTCLFEKCELATCTPRDQNRDGTGSSANDICSSVSFKDDLADFAKTVNSCIKFISNSMLQSIQVLRFHLLELEKVHELCDNFCHRYVTCLKGKMPMDIVGDERASSSQPPLSPSTTVPSSSPSMGTSQYHQPYEPQTVPLPENTSTITAGNPDRITKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QLQ3</accession>
    <name>A0A3P7QLQ3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QLQ3"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF30">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="190" mass="22291" checksum="68CCFEABA804DD72" modified="2019-02-13" version="1">MLIIFSMDNHVDHSNHQNRESTNVGNNHLFGHAMTFHFGLNEVILFSFWSVNGLTAMIASCIIIIFLCFIMEIIRLIRSIRICYERKKEESNTNAIWKISPQVNFNTCIDSFLHAIQLTISYLLMLLFMTFNVWICLAVIGGEVMTRFCLKVIFRNIQIAVRFFFSTLYKLSKIFSIFFIFITILFNIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SV54</accession>
    <name>A0A3P7SV54_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SV54"/>
    <dbReference type="STRING" id="318479.A0A3P7SV54"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="163" mass="17966" checksum="05B1049DCC7FD39C" modified="2019-02-13" version="1">MKAIGLVQRWLLNYSQWLPKHNHAVFLTKYDLLASKGDSSTQGMAYVGTMCHIGDSVSIVEDIGGMATAIVAIHEIVHSLGAYHDGINLSEDCDERMNYIMAPLISGSEDEQKFSNSFKLSKCSIRQIEMFLASLPGELITKQRQCAISFGSHYGICAVSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SW00</accession>
    <name>A0A3P7SW00_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Interferon regulatory factor 2-binding protein 1/2-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SW00"/>
    <dbReference type="OrthoDB" id="10065080at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="304" mass="33563" checksum="6AEFC41D038DAA48" modified="2019-02-13" version="1">MNGMLATMNGTTHPTNNSTTNSNNSKLAGRQHCFLCDLPRWPWAMCNDYLEPVCRGCVNYEGADRQSFSITLNIFVSTISIQFFFAYFRIENVIESARQLKRVHGFPVGESVNSLSNRSAINQKESLLQTTAGRYSPAVSRGVNPVPPSTQQPIVQQQQQQVAVAAAAAAAVQMPQLPQLNQLTEALVQQQRFMTLAGRPPGQFTAEDLHTLQQLQRPLHLQNPLIQHGIPMGVFPNLVASSVASLLPQNASLAAAVAASRKREHDIDDIKPDVYGKVQRGKKFYLNLNIIIDRNLTTNLIGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U174</accession>
    <name>A0A0N4U174_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family D member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4698</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U174"/>
    <dbReference type="STRING" id="318479.A0A0N4U174"/>
    <dbReference type="WBParaSite" id="DME_0000033801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000033801-mRNA-1"/>
        <property type="gene ID" value="DME_0000033801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="437"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000033801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="676" mass="76911" checksum="318F1688FF8A2A70" modified="2015-12-09" version="1">MKKFSLDLLFVRRFITLLKILFPFDRHRLVVPTSIHFALFVAIVSAADQVATYFVGILPSEFYVALGNRDFSTFRLLAAKATVIILGKALALSAIKYSTSQLFLKFREIFGYTLHRLYFKRHAYYRLNVLGENVDNPDQRMTQDVEKTTRILAQDLFVPIFISPFIIVYYTYLTYGSSGWLGPLAIYAYFMIATVINKLLLSPIVALVNEQEKKEGEFRLRHVEVRTNAESIAFYQSGLIENVMMNKKLNSLINVQKRLVEWRFALCLATSAFDYFGGTLSYLIIAIPIFLTNDYEGLSGSELSGVVSRNAFFYLYLIYSFTRLISLSETIGDLAGVTHRLSSFRVIGLYEELMRLHIDRLETDRPPSTVPSSIVVMATEDSEKSDVPQRRVEELHGKQCRLLDIDSDDEEAEYLLERSDGNRIRDDPEWLDDGISMTLDSVTIVLPSDVTSPLVSNLSMQIIQGKNMLITGDSSSGKTSILRVLAGLWNCVAGKIERHWKSRPSTLLFLPQKPYFPSGGCTLRQQLVYPLKALPLEKGLEMNRLTQILEMIKMEQLLQRCNGFDTPTDWDWSEVLSPGELQRLSIGRLLYHRPRIAFLDEATSAIGFEAEMALYHLLQEENISYVSVGHRYSLRQFHDVELHLNGHGEWCISDIDNASLENRAANLVCGQTVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1A4</accession>
    <name>A0A0N4U1A4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4733</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1A4"/>
    <dbReference type="WBParaSite" id="DME_0000037301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000037301-mRNA-1"/>
        <property type="gene ID" value="DME_0000037301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5774172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035161">
        <property type="entry name" value="DUF5332"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38612:SF1">
        <property type="entry name" value="PROTEIN CBG06620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38612">
        <property type="entry name" value="PROTEIN DCT-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17266">
        <property type="entry name" value="DUF5332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041121250" evidence="1">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000037301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23129" checksum="A7C7CF3F3DFAC7F2" modified="2015-12-09" version="1">MRSVAVVIFILPFVTLDETLNQKCRKLLLCSIKKDCVNLRYLVEKFNGAVINKRLYSDLDSSIDYGCIFTSGCSDECNNCPLCLTSKEQLVDVLSGTRRALNGECSTLVNCATDCVAQSNANFTTINYCLRHLCAFHCFDGSCNKCSAFVTRLFNQICVSAGFRRMVKQFDGQCYELFKQIVYSKFKEQFKRNGKQPAIGVHQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1G8</accession>
    <name>A0A0N4U1G8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS4810</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1G8"/>
    <dbReference type="STRING" id="318479.A0A0N4U1G8"/>
    <dbReference type="WBParaSite" id="DME_0000045001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000045001-mRNA-1"/>
        <property type="gene ID" value="DME_0000045001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048337">
        <property type="term" value="P:positive regulation of mesodermal cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000398">
        <property type="entry name" value="Homeobox protein lin-39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000045001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13994" checksum="4961938DF5A0F071" modified="2015-12-09" version="1">MDEIKCNNRGEKRQRTAYTRNQVLELEKEFHFNKYLTRKRRIEIAHSLMLTERQVKIWFQNRRMKHKKENKEKPTSSSSSTVSSSTIPFPTTTTTALPFHHLTSFNTRNFLLTNNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1R5</accession>
    <name>A0A0N4U1R5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4923</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1R5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1R5"/>
    <dbReference type="WBParaSite" id="DME_0000056301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000056301-mRNA-1"/>
        <property type="gene ID" value="DME_0000056301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000056301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38743" checksum="2F1792386A957C20" modified="2015-12-09" version="1">MSEAAKAMLAAKKRHEEEEAAKMQDYEEKRRVEREKIEEELRNLREKQERRRQERAEEEREFAEKIRMAEERRRQEEEDSKARIAAQKVKRDEERKKRQQTIAGSLAGATASGEIRPNYIVTKKQNIDKFGPISQKTEQTKEQKEEAKRAFMAIINRFPDITNMLANDLKNNIKQLYQRICKLEAEKYDLEKRHERQEYDLKELHEREKQMARNKALQKGLDPEEAAASIHPPKVNVASKFDRQIDRRSYGDRRTLFENPIIKKPPKIVHGTARPPPEWGRTSNEELEQLRKVLEPPKYVEQVKVEGAKPPVEPIPLSIPEVNEIDVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U297</accession>
    <name>A0A0N4U297_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5146</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U297"/>
    <dbReference type="WBParaSite" id="DME_0000078601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000078601-mRNA-1"/>
        <property type="gene ID" value="DME_0000078601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000078601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15640" checksum="28FB238875B74646" modified="2015-12-09" version="1">MIGIQVSYKYLGIPWYHMRRQERRQYLSIVKGQDLEETAQREEENPCHEYASHAAGTARCTKEDMEVRLGECECENHYLETRNIQKYNSKMAPKDEQLKECLKYVKTLENHQEEKIRWQRSFMDYTIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2A9</accession>
    <name>A0A0N4U2A9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2A9"/>
    <dbReference type="WBParaSite" id="DME_0000080001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000080001-mRNA-1"/>
        <property type="gene ID" value="DME_0000080001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000080001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9786" checksum="708EFD84648DE490" modified="2015-12-09" version="1">MADCLQRSDGNTIVEEELRYWIRQIFAKWFLQSFFTVRLCHLNKRVHNPFIGPHHVDYGDAFGITIRDGEAVIAQQFPCSFANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2S6</accession>
    <name>A0A0N4U2S6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XK-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5361</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2S6"/>
    <dbReference type="WBParaSite" id="DME_0000100101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000100101-mRNA-1"/>
        <property type="gene ID" value="DME_0000100101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5802415at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000100101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35906" checksum="98BD7AE0D7806EFA" modified="2015-12-09" version="1">MCLAHHRDFGDRSHSCKAGFSMPSLSAWSPYYVKTHYEVNEWKSTGEKSTHQSSEPILCGILIGIRVLSIMLQLIYAHYTKLLVLFTVAIIHAAYMKPFLDVYAILADYEGALVTAGRTREFFLLRQQVDILTAVRTLEVFLQFSIFFFIFHFQYKKNMWMTVGSMCVALSCSGILLVFHGATAYKTAYYIAMQLADLLSFSTLPALLFARSILVDKIHANLPKFLLDMQFSSKFKELPVLLKCSNERVPHCFEIVINSIFPMFILKFLVILAVVTILYLALAYLLEWCIKHWFPHAEGRVRQRFYSPLVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3J8</accession>
    <name>A0A0N4U3J8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5665</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3J8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3J8"/>
    <dbReference type="WBParaSite" id="DME_0000130501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000130501-mRNA-1"/>
        <property type="gene ID" value="DME_0000130501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000130501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20140" checksum="F9EBCCFA9F4CDBA8" modified="2015-12-09" version="1">MPFMHGSMPLRRTYFYLNQGTIFFRDVVKVLAFGFHRRPTPEQKGARDFIFWHWAQLQFQNPKVQLVKYVDFTPIPFVQAFLDDGREVLFDLDGKSREEIIEILKGTLGKTNLVLRREKFERVIEKNPSSFGEDCSRQCICTVQGQYPCTGLLAAPDYLKGTWRWHKNCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3K8</accession>
    <name>A0A0N4U3K8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab-28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5675</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3K8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3K8"/>
    <dbReference type="WBParaSite" id="DME_0000131501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000131501-mRNA-1"/>
        <property type="gene ID" value="DME_0000131501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000131501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31720" checksum="E595388B91005C75" modified="2015-12-09" version="1">MESDEEDARDGTVLKIVVCGDGASGKTSLCIRVAQDNFTRQYQQASNKFIFYQIFFFPFILIYLAKSFSTYKTIITVYIRCTLAVNQFGIFNSIRLVKKIDTVGLDFFSRRLALPGDISVLLQIWDIGGQSIASPMLEKYIYGAHGALVVYDVTNGSSFENLGDWVNSIKKITKTQEKPVKMSLVGNKTDLEHRRAVRIDKHAKFAELHSMSSYYVSAKTGDSVMLMFRQITCEILGIQLNKSDMEADIIVVKAPIATNSAETNTKFVRRTNQSHNTAVCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4Q0</accession>
    <name>A0A0N4U4Q0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6131</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4Q0"/>
    <dbReference type="WBParaSite" id="DME_0000177101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000177101-mRNA-1"/>
        <property type="gene ID" value="DME_0000177101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000177101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13121" checksum="838F3FAFF6B9C5EA" modified="2015-12-09" version="1">MLNKRNTRCYDNVTRKEWEEFKNSGILRIETILYAFFGQLPLPISLVALTLCLPYTIAIFRCIRSNKIMVMWFEHLTFVSLVHSGPLQSRTYQSVYANYMRYGSPYIIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5H9</accession>
    <name>A0A0N4U5H9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6465</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5H9"/>
    <dbReference type="STRING" id="318479.A0A0N4U5H9"/>
    <dbReference type="WBParaSite" id="DME_0000210501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000210501-mRNA-1"/>
        <property type="gene ID" value="DME_0000210501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="379"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="1499"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000210501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1610" mass="177135" checksum="756FC08183F2258C" modified="2016-06-08" version="2">MYVLLSHHKAELENLAVATNSHYYGMPHKNSFTRFGHEIDLKHMDGAFRSPRNSVVKIGPYNDCMQIFRSNNIPHRYSTDHQQRMRKTKKRDFKQSRPPKRKVGRLIGEDILKITHLRDWHHNKSSCDDQILNTSNEAEIISTAIANAITKMSGSKPRWASQKSIESTTSASNSCSTTPVMQRRQQRSTHLTDSSSESVGSVEIVLESLRRSLAKQAALTGRKPCNKLSEGASVVVEQDELITRSANYNNHEEQNFVDQKLADYKQICDLHLGKEGNIRISDLSCCWFFYNAQILKHCRNLSLQRPKKKPLHEYYNDDDIELEALAKVVDPSAPRPEGVIISPARGDHASVSTSLPRSIDSALHRYGTTQQKAIAAVVLDHSGKPAYSITYGKLLNRAIKVAHMLLMKQISGSMGKEKFHLCKTGDRVALVYPNTEPLSFLVAFYGCLLAGVIPVPIEVPITKRDAGIQQLGFLLGSCGVKVALTSEACYKGLPKRQSSSHSNGSGPIMPGNDIVDFKGWPQLAWVVTEHLNKPPKDWSVPPRITDESIAYIEYTSDREGSMKGVCYTRQSMVAHCRSITTAMGYNESDIMVSVLDFKRETGLWHSVLSSVFAGLRVIFIPYSLMKINPASWMQMVTRYQAKFALVKSRDLHWGLLATRDHKDINLSSLKSILVADGANPWSLSSCDQFASTFHSKGLRPDALCPCAGSSETGSISLRRPAVEENICNTGRGVLSMSALSHSVVRVDRENSLTSLTLQDAGQVIPGGVAIVVKPSGPPRLCRADEIGEICIHAHSTGCAYWGLDGLSTFTFKVEPLAADDRPLGPLPYVRSGLLGFLGPNGLVFVIGNRNSQMLVSGRQHSADDLIATVLAVEPMKFIYRGRIAIFSIRVLRDERICIVAEQKPGISEEDSFSWMSRVLQAIDSIHQVGIYCLALVPSNQLPKTPLGGIHMSETRQRFIDGTLHPATLLMCPHSCVINLPKPREQQSDIGPAAMFVGNIVQGMRIAGAKGRDIGPDDDKMSLIDVLRQRSQTSPEHVLFTLMNARGTEVDSVTCLQLLKKAERIGSLLIDKGHLNAGDHVALIFPPGIDLIAAFYGCQSVGLVPVCIRPPHPHNLQTTLPTVRMIVDVSKAVALLSTSAMIKLLKCKEASIRVDAKAWPTILDVDDMSSSSKKRIEFETYERKLSDVCYLDFSISTTGQLAGIMVSGKGVGALCRSLKVACELYPSRHITLCLDPYCGLGFALWCLSSVYSGHHSLLIPPSEVEQNPALWLTAVSQRKVRDTFCSYGVMELCVRELAPQIALLKDKGISLSSIRTCVVVAEERPRVALCTAFTKLFSPLGLNARAVSTSFGCRVNTAICMQGASSPDPATVYVDARALRNDRVTLVEKGAPHSIALMESGKLLPGVEVVIANPETKGQCADSHLGEIWVTSAHNAMGYFTVYGVETSLHADHFNARLTTGDTKKQFARTGYTGFLRQTQSITADGELHDAVFVVGALDETLMLRGMRYHPVDIEATVIRAHKKIMECAVFTWTHLLVAVAETEGLESEALDLIPAITSAILEDHHLIVGVVVIVDPGIIPINSRGEKQRMHLRDAFLHDQLDPIYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P0</accession>
    <name>A0A0N4U5P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P0"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P0"/>
    <dbReference type="WBParaSite" id="DME_0000217501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000217501-mRNA-1"/>
        <property type="gene ID" value="DME_0000217501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000217501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43177" checksum="C2B0E49D81C37043" modified="2015-12-09" version="1">MKISRITFAVVAAISGISTAFCPLAASYGIVAFIICRILQGDFSVNLCQLWTVILPVIYSVGFGVCMPIIGSTTSTWARFDENGLFSGALTGFIQISPVITMPMSGLLCVSSLRWPFIYYVHAIITFVLILLWLIFYSDSPTKNRFIEKIEIDEIQRNKTVNEKAKKIPFLEIFKTRSVWALWIAAVGNMYSIQMMIVFSPTYINQILLIPIVNVGFASALPTLLQFVVKLFAGYISDKIYFLGEASKIRLFNSIAFLGMGAFMIALAIAQNFSSTLSIIFLISSVTILGFNTGGFFKGSTIIGQQYSYFINAIIQFIMCISMLTTPIIIFQLTKNGEKSEWLIVFVAHALLLFLTNAIFCIFGNAIPASFTKTQINKSNGLDYVPCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5T2</accession>
    <name>A0A0N4U5T2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6588</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5T2"/>
    <dbReference type="STRING" id="318479.A0A0N4U5T2"/>
    <dbReference type="WBParaSite" id="DME_0000222801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000222801-mRNA-1"/>
        <property type="gene ID" value="DME_0000222801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF9">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000222801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15519" checksum="CB36EF921EC45944" modified="2015-12-09" version="1">MSEIVDGLFISGISGLRTTKIHEKGITHIINATSEVPNLKALGNIERTKLWLENTPQTYIYPHLELLSDQIEAIIHDGGKVLVHCVCGTSRSPTIGLAFLTKHRCRTLRDAYCLMSRKHPIVQPNIGFWKQLITFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U615</accession>
    <name>A0A0N4U615_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6690</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U615"/>
    <dbReference type="STRING" id="318479.A0A0N4U615"/>
    <dbReference type="WBParaSite" id="DME_0000233001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000233001-mRNA-1"/>
        <property type="gene ID" value="DME_0000233001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF51">
        <property type="entry name" value="CUTICLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229867" evidence="8">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000233001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34040" checksum="0E76B45DDD036768" modified="2015-12-09" version="1">MLNEFLITALPITLLATPIENYIEGEPKIRCDSDAIDINFQTRQPFNGRIYVKGRNTESGCHNEQIGRHLTGITLHFGTCGMVRLRSLEPRGVFLSIAIVLSFHPKFITKADKVYNIQCFYMESVKDVDNNLEAVELISIFVMQNAIMPNCRYEILDRGPNGKPIQFALIGQQVYHKWFCEETIRSAFCMIVHSCFMSDGQGNRINVIDENGCTIDEYILDDLEYLGDLIAGKEANIVKYHDRETLGFQCQISLSIKEGQCARPQCENIRKRRQIFKIFSYLIEEKGSQSLSFYGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6L4</accession>
    <name>A0A0N4U6L4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipoma-preferred partner</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6932</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6L4"/>
    <dbReference type="STRING" id="318479.A0A0N4U6L4"/>
    <dbReference type="WBParaSite" id="DME_0000257201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000257201-mRNA-1"/>
        <property type="gene ID" value="DME_0000257201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000057">
        <property type="entry name" value="Zyxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207:SF2">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20110" checksum="6A2F4DB840CCAAED" modified="2015-12-09" version="1">NCNKCGEAITSSRSGCTALDQTFHIACFTCKECDKPLAGGSFYNVDGKPLCEQDYKNTLERCSSCGEPIMDKLLRASGGTYHPACFVCTICKKCLDGIPFTVNSSNQIHCVECFHEKYAPRCAVCSKPIIPEDGEKESVRVVAMDKSFHVNCYRCEDCNLQLSSKLEGQGLAFYIRLLSLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7G5</accession>
    <name>A0A0N4U7G5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS155</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7G5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7G5"/>
    <dbReference type="WBParaSite" id="DME_0000292601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000292601-mRNA-1"/>
        <property type="gene ID" value="DME_0000292601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000292601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24766" checksum="D7AE46B70019EB8D" modified="2015-12-09" version="1">MVWLFGPSKPQVQMVAVDDNHDLSSSLTSDLSSDNNISRLPQPMIALDEIKQSGLPIHQQIAPYLQMDPSVFQQATPEYVMPVGTTGKGKFEFALGNIGWGVIGGYSFGCMRGFLPEFFNRDTKQLRGKPWVTRMVNATVKHGSGYAQPAGAIVVMYSLLELILRKLRADDDLNSIAAGGLTGAIYRSPYGLRASAVGSIFGFAIATLWVLAQTDSRQRITEINYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7X3</accession>
    <name>A0A0N4U7X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SpoIID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7268</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7X3"/>
    <dbReference type="WBParaSite" id="DME_0000310901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000310901-mRNA-1"/>
        <property type="gene ID" value="DME_0000310901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5815737at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000310901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13303" checksum="4021B8E52C6C8316" modified="2015-12-09" version="1">MKKENDLGRNFYKVVVIGLLIAICVNTNDGAVSVMPVKLGTNVDIDFGKEVKAVRIDVNGERKHIVEDGALTEFGAKKFGGRAKFVDGKLTIDNLHRDDIIDFFYETDKYPMAITLSTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U837</accession>
    <name>A0A0N4U837_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7342</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U837"/>
    <dbReference type="STRING" id="318479.A0A0N4U837"/>
    <dbReference type="WBParaSite" id="DME_0000318301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000318301-mRNA-1"/>
        <property type="gene ID" value="DME_0000318301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000318301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19042" checksum="76388BA2424FD8AF" modified="2015-12-09" version="1">MGGVLSYFRGLFGQKELRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYANTDAIIYVVDSADKDRIGISKQELEEELKDATLMILANKQDINGCLSLAEIHRCLGLEALRTRTFQIFKTSAIKGDGLDEAMEWLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U862</accession>
    <name>A0A0N4U862_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7370</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U862"/>
    <dbReference type="STRING" id="318479.A0A0N4U862"/>
    <dbReference type="WBParaSite" id="DME_0000321101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000321101-mRNA-1"/>
        <property type="gene ID" value="DME_0000321101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase e1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000135">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="633"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000321101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1024" mass="115882" checksum="FB515E351A9F7A49" modified="2015-12-09" version="1">MLLNRLFAPRFQILKFGAKYAYLVGDIRITSSSSSVKAEPFMNGTSTIYIEQMYRCWKNDPNSVHASWNAYFQNVENGLPPGFAYSTPPSLGVTYANSIVPPVNAIISSPSTSLKETHDNLQVQLLIRNYQTLGHSVANIDPLNISNTNLESKMPPEFRLDFYGFGEQDLDREFVLPTSTYIGGNSPTLKLREIIDRLKNVYCKSVGIEYMHLTNSKQSEWIRKRFEAPIKQLSTSQKKTLYNRLMRSTKFEEFLAKKWPNEKRFGLEGCEVLIPAIKQIIDTSSIAGVQSFIIGMPHRGRLNVLANVCRQPLPKIFCQFSGLQPADEGSGDVKYHLGVCVERLNRQSDRNVSITLLANPSHLEAIDPVVMGRVRAEAFYSGDENVEHSLGILIHGDAAFTGQGVVMETFNLDDLRDYTTHGAIHLVVNNQIGFTTDPCCSHSSPYCTDIGRFIGCPIFHVNSDDPEAVMYVCNVVAEWRRIFKKDAIIDIVCYRRYGHNELDEPMFTQPLMYQKIKEMLPISTKYQNQILSEGIVDEQYIKDEEKKYSAILESAYESAQKATHVHFRDWLDYPWADFFDKRDPLNIPATGIPNETIELIIKKFSSVPEGFNVHQSLLRTLKGRQQMLKENCADWAMGEALAFGSLLLEGTHIRLSGQDVERGTFSHRHHVLHDQKIDQKVYEPLNDLSDTVIFYGVYGVYGVFYGQAKYVVCNSSLSEYAVLGFELGYSMVDPNSLVIWEAQFGDFANTAQCIIDQFISSGQSKWIRQSGVVLSLPHGYEGMGPEHSSARLERYLQMCNEDDEIDIEAEAFGSTYEAQQLNDTNWIVANCTTPANYFHLLRRQIIMPFRKPLISMAPKSLLRHPSARSPIEDFLPDTKFQRVIRENGEASKCPNRVSRLIFCTGKVYYDLITARKGLNMDSQIAICRIEQISPFPYDLLVAECALYINAEVVWAQEEHKNMGAWSFVQPRMNSILAKDGRVMKYAGRKPSSSPAAGNKFLHGSEQKNFLAQALTNQSGQSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8F0</accession>
    <name>A0A0N4U8F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7475</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8F0"/>
    <dbReference type="STRING" id="318479.A0A0N4U8F0"/>
    <dbReference type="WBParaSite" id="DME_0000331601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000331601-mRNA-1"/>
        <property type="gene ID" value="DME_0000331601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001348">
        <property type="entry name" value="Ras and EF-hand domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="210"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000331601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="604" mass="69320" checksum="7EAED4262768638F" modified="2015-12-09" version="1">MDPIMIETERMFELCDQENKGYLTPDNLKAVCPQLDDQDIQFIFSSLDTDGSGRIEREEFLGGFQSVLCKGENADCALFQNRKLMDFLSVQIYSTRLLGLPGMMRRASIVETNCQRNDNSSNIKLLDEIISASESEDTSRRRKKPNEDVFNSDPEALKFDLSLPCQDDLLQLYEQIQLCGTPELLHRFEKVVGSFCKEVKEQKEENKRLQNIFTSERESYNRRMQEVENEIDQQIAYTERKVREEEAKKLAQEKEEMRLRMENELEELKQNIARMEKFEKMLKKESEKEGQTTQLREKLNALAMENQSLKSNLADSHLELAVIKSELASVKADYETKKEEMLSDSEVMMQTAKKTENLQRQLQLLYDANKKLHDTNDSLREALEQRAFAFRQLDLAFDEANGPPERTFRVVMCGDASVGKSSIVMRIVKGIFCTNLPSTLGVDFHIKTARIDEKNVAIQLWDTAGQERFRSLCKSYFRRADGAILVYDCMNEQSFLRVREWIDTIKESTPRIIPIMVCANKIDLRDNKTGANERRNHVSTEDGSATAAAMGVLFTECSALNGANIDEALLYLTRELMATEDVEIKGTSVILSRKLPKSSCCSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8N0</accession>
    <name>A0A0N4U8N0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS279</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8N0"/>
    <dbReference type="WBParaSite" id="DME_0000341301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000341301-mRNA-1"/>
        <property type="gene ID" value="DME_0000341301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000341301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9414" checksum="F038B3B0A3CBC0E1" modified="2015-12-09" version="1">MKITVTGLPATQFRKMLIYATLLNTRRLYHLQQRLVETKDRAVPPLQPQITVAICFNNAQELAVIVRNLYNYTSIFTLHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8U8</accession>
    <name>A0A0N4U8U8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS352</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8U8"/>
    <dbReference type="WBParaSite" id="DME_0000348601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000348601-mRNA-1"/>
        <property type="gene ID" value="DME_0000348601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF4">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000348601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25193" checksum="E84C8B4002FC4129" modified="2015-12-09" version="1">MTVLMVISANKNRNMLPCEHIPKLFCCTEFILEICIGKCIDIAAKKCHKKLSLHKFYSRFSKKSNDVTNAEIKPLILIFIAPFEKYSIGASIARPPNKVISGHLSSDCGSASNSESSPPYSPCPPKNIVDDFFLHCCKQQQLVEANCHGLCSYEHREQQISELLTHALRKRLCSCLGMCNIEHLVDSDDKIMNIKKNYLVCFSNWNILIHCAHAGIRYMTDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U955</accession>
    <name>A0A0N4U955_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7606</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U955"/>
    <dbReference type="WBParaSite" id="DME_0000360101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000360101-mRNA-1"/>
        <property type="gene ID" value="DME_0000360101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000360101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6660" checksum="C2E34247662BB733" modified="2015-12-09" version="1">MTKVMQALGMLHHLTKTKSNVARRASSASCKLRNCKIETLKKTRENSCHNGKNSVECER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9D2</accession>
    <name>A0A0N4U9D2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7689</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9D2"/>
    <dbReference type="WBParaSite" id="DME_0000368401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000368401-mRNA-1"/>
        <property type="gene ID" value="DME_0000368401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000368401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10435" checksum="6BC85AAAD869A46A" modified="2015-12-09" version="1">MASFDSHDTPRPVVRAIRIQSGCKTVPRFIHKIGSQTGQLLETYQKERLFRGKLLTGVENAYGHSKPSYRLSEVRLLHFGSQLIANLGLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9U2</accession>
    <name>A0A0N4U9U2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DME_LOCUS7880</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9U2"/>
    <dbReference type="STRING" id="318479.A0A0N4U9U2"/>
    <dbReference type="WBParaSite" id="DME_0000387501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000387501-mRNA-1"/>
        <property type="gene ID" value="DME_0000387501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF9">
        <property type="entry name" value="INNEXIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN57907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000387501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45434" checksum="491E85F723B77F5D" modified="2015-12-09" version="1">MSLLFSVVRSVPFSNKPIAKDVIASLHSYFTCNILIIFAVILSFKHFGGRPIECLLPSGFSGAWEQYAENFCWAENTYFVSPGIFVEQVSVSDRRERRINYYQWMPFFLLFQAACFNASTLIWKYFAGHSGIKMGEILRLACDPLNANLTVKKMNINALNIHLQGALRFQERLKKRKLVPHKIFRFLNLRYSSFYISVVYMTAKCAFLFNACFQLHLLSSYLLSNIRYDFGLNAWCNLLFPSGNESSWNTTGVFPRVALCDFEVREMGNTHTHTVQCVLVVNIFTEKIFILLWTWFVILAIVTVMSIINWAYLLLSSCSKEHFILNHLEMGETKLDKENCETQKSVKKFLNKYLGIDGILVLRMIAAHADIVFSTELIVSLWQSHCHFESFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA22</accession>
    <name>A0A0N4UA22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7974</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN58001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA22"/>
    <dbReference type="WBParaSite" id="DME_0000396901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000396901-mRNA-1"/>
        <property type="gene ID" value="DME_0000396901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868512at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000396901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29302" checksum="F217C6812614EF71" modified="2015-12-09" version="1">MKHNNTNRTDYENTKNHFLSRYGYSPAPSAPKLEVTINQNCDAPSYSPKALLRPPTSPPPPPPFKSDYAAPTETTYEPLWLDKFPRRENKGMFRVALVQALLAGVILGGGIWCYCDTPDYCPYYSAIWTSSVYLLNAIIGSAAAKIGSINLYIFHLVLSMISITTCSISAIISARNWILVGTYQHPKIDRNQAFCLIGEHDAPRLSYIFSHMDQYDFQACLFQLKVGVAVNSVQFVIAGIEALLNVVSAFLCFKRTCTSSCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA45</accession>
    <name>A0A0N4UA45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS362</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA45"/>
    <dbReference type="WBParaSite" id="DME_0000399801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000399801-mRNA-1"/>
        <property type="gene ID" value="DME_0000399801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720894" evidence="3">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000399801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23079" checksum="A7B2CB1417540105" modified="2015-12-09" version="1">MLRLTNNFVFAYLIQTSLAYTQPECHTISVILGTLFISFLAFTLLLSMLYCAYFKSVYDSYEEMEQNKAQKDGLHSENEHKYFENYYFQYCPSVRQRNISLYDVQTLHQPSSNETYSPEATRNLEPIINTLMEKQVDEKRHRKYVRWKQNDRFKNGISAALSRRYDGARRARSLSPSMTTVDSLGTDVQSTEYEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAB5</accession>
    <name>A0A0N4UAB5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS444</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAB5"/>
    <dbReference type="WBParaSite" id="DME_0000408001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000408001-mRNA-1"/>
        <property type="gene ID" value="DME_0000408001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000408001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16243" checksum="D7D953666439A255" modified="2015-12-09" version="1">MFIEWLIINMLIPLAFGAIGGLVGRTQSTAVQGTLTCNGRPLKNVLVKLYDNDRGIGFDDFMGETTSDEKGFFYVSGSNAEISDIDPKFNIYHDCNDWYWPCQRKISIMIPDDYITVGDVPKKTYNSGIIELAGEFSGETRDCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAG0</accession>
    <name>A0A0N4UAG0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8018</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenomatous polyposis coli (APC) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAG0"/>
    <dbReference type="STRING" id="318479.A0A0N4UAG0"/>
    <dbReference type="WBParaSite" id="DME_0000413501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000413501-mRNA-1"/>
        <property type="gene ID" value="DME_0000413501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918429at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF12">
        <property type="entry name" value="APC-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000413501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119994" checksum="21CF04C3D6209B2E" modified="2016-06-08" version="2">MVGDLESRIDELLNSLRFSTMRNRPPQESDGSRLKAFHHRLKSLVAEEFDDYKYITRSDFIFLSSITKYFGNSILKRRRLKHILPAVICVREQLLFLRKCLHSSNIVSTSQYISKMHVALTAIMKESFQEDCRKAAIVLGALDVVAETLVLDIEYFGTKCNQENRVIRKLVASCLTNLTYGNLMCKRKLCAYPNFIENVIKVIAESHYLAQVYAGLLRNLSWMADSEMSAALLSTVSPLAHASVAAFKFGEMKCLCSSLAALWNLASHSKENKKALCDEPDFLESLIEIMGADSQQTALLESATGIFKYSTMYLVAAGVEQYLSVNLRYRLVFCLVNLLNSPSFTIIGNGLGIMMQLLAKDQQLRLHLRLNQKAMQYLNHLRNSAREDIRNPVKAILNYINSSELNEMVDRPHSAHQYCKPCSMQHLSQQCRHHVPQSYSAQDAGHPHPAQAFAQYSTIPGFFNVEGMSSSYGGSTTSSPFLEPTRLLKLRSAQTHLHNLALNRVDCNDIFSLMEPNKSVSQNFTPREVADNFASLPLLKNSADLLKSTTGTKVNQSSSQTRNLIVDNELVDTELMKLNEPSYEIDESVRCTRCTSTQSLTSLLPADKSAWESVNNSAVNSNRLSPVSATDIPDSPTQCAASNDTEIVVKKEQHSGHDNVDPILKGSDTNQNVDQQLISNLDNVKLSTGNSSVNESGDYGIFSGKIDSELLIQSIEAAMPKKNPANDDFLALMIEKAQPKPNRMLSSLPNYSHAPTAKPIYDSSSSKAEDDDFLMQSIASVLPQNHRSGPELFLGNQSKKGRAMMGEVARPSKGPKQNAHATFTTSKCSSNKKIPQARVMPNAFLGTLPTKKETNSISISSSLILNAALQNSSLVESPETSEKIRDASTLRLHPNEESDTLSEDSYSKCEVDDEAVYSAIPIDVDQEIHAEQLLIDCNIIGVTSHKTKNATFQSLRFVFLIPFLLTPFFIANSIDIPKSQMIISGSSRLCKRFKKSGRNKQKELKESVICDISAEVSEKSGLSADTGEHRIQQPNNLSIIKGKIVQPRSNKSTHMKNNSASSKISNIPRNASKFVDIGGMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAP1</accession>
    <name>A0A0N4UAP1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8115</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAP1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAP1"/>
    <dbReference type="WBParaSite" id="DME_0000423201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000423201-mRNA-1"/>
        <property type="gene ID" value="DME_0000423201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="303"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000423201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44528" checksum="B841C3C075D687B4" modified="2015-12-09" version="1">MAPKKKEIEEHPPPLMGRIGTNLKMGILGLPNVGKSTFFNVLTKSQAQAENFPFCTIDPNESRVPVSDKRFDWLVEHFKPASRVPAFLNVTDIAGLVKGASEGQGLGNAFLSHVSACDALFHLCRAFDDDDVTHVEGDVNPVRDLEIIGTELIKKDLQYLEGAIDKLEKQAIRGGDKSKKPEYETLLKVKKLLEEDKKPVRLEIWNEKEIDALNKHLLLTAKPIVYLVNLSEKDYVRKKNKWLAKIKAWLDENDPHAACIPFSGILELKLMDMSAEEKEKYLKEINSTSALDRIVKTGYKALQLEYFFTCGKDEVKAWTIQKGTKAPQAAGKIHSDFEKGFIMAEIYKADDIMELGNENAVKAAGKYRQQGRNHIVEDGDVILFKFNAGAGLTSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBH7</accession>
    <name>A0A0N4UBH7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS8438</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBH7"/>
    <dbReference type="STRING" id="318479.A0A0N4UBH7"/>
    <dbReference type="WBParaSite" id="DME_0000455501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000455501-mRNA-1"/>
        <property type="gene ID" value="DME_0000455501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="286"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN58465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000455501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="807" mass="91250" checksum="C0E0AB49B733CECE" modified="2016-06-08" version="2">MDIRHTQGIVLEYLNFLDDENEDRIYTSKAEDLIKDEGLRMVININDVRRKIPFRANSLIKNFVDEIVCFEQALNDFITRLDAGYAMGRQFHIGFEGSFGDRHVNPRSLKSHLLGNLVCCEGIVTKCSIIRPKVVKSVHYCSATKKTIERVYTDFTSYEAFPSSNVYPTEDENKNPLETEFGLCTYKDHQTFSIQELPEHAPPGQLPRSLDIIVDEDLADSCKPGDRVRVVGLYRCLPNKQNGFSSGSFRTVLITNNVQLLSKEMQPTFMSSDIRNIRRLSRNKDIMNILARSLAPSIWGHEEVKKAILCLLLGGTEKILANGSRLRGDINILLIGDPSVAKSQLLRYVLHTAPRAIATTGRGSSGVGLTAAVTTDADTGDRRLEAGAMVLGDRGIVCIDEFDKMSDIDRTSIHEVMEQGRVTIAKAGIHAKLNARCSVLAAANPVFGRYNIYKSPMHNIGMQDSLLSRFDLIFVMLDQHDLGQDKSVAEHILKLHRYRAPGESEGSVLQMGAAIETLSTFDFLDEEANVTADIYEKNKIWCSSAPNEKILTMRFLRKYLHMAKGVKPVLTEEAAAYISKSYTELRSFDTSKTDQERTMPVTVRQLETMIRLATAMAKARFSKEVEQEDAENAFNLLHFACFKEKPRERLDMEDRTGRKRHQKDIEIDESDVDDMLEEVNELTVDSNRRRSTRLKRQAVDTQDQETQDASMDVTETTTESIQHSLKKPRLDIPAISVDRYKIFRKYIRKAFDDIGPTTEMIELSRIRDSVQSQAGLLTFTQEELNAGFEQLCNENIAMIANDQITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCL3</accession>
    <name>A0A0N4UCL3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8810</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCL3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCL3"/>
    <dbReference type="WBParaSite" id="DME_0000501101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000501101-mRNA-1"/>
        <property type="gene ID" value="DME_0000501101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
        <property type="entry name" value="CCD_aECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435">
        <property type="entry name" value="PROTEIN CBG14344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23626">
        <property type="entry name" value="CCD_aECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042814" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="aECM cysteine-cradle" evidence="2">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000501101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20529" checksum="F47EA2221D19AB61" modified="2015-12-09" version="1">MSPIRFLLLILLSIEITLTISNFAYNGITNAIMPKRLNAISITMKGNHSQPLNYRNRAGSFNRINRLKFLKRFNLKLLTNTSNIFSPTKALRRIIIQMRKARFNAVPTINLSKSVQPDKNQYDMKFCESIKKTTKHYGLRDFPKFARNNCSIIRIYFRKVSCEDIVNIADFCFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCS1</accession>
    <name>A0A0N4UCS1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8878</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCS1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCS1"/>
    <dbReference type="WBParaSite" id="DME_0000507901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000507901-mRNA-1"/>
        <property type="gene ID" value="DME_0000507901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000507901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15870" checksum="7EEE09B1BA225DB9" modified="2015-12-09" version="1">MASQLDENNQEKKSEMAQSMESLIESLLKCDAVKFGEFVLKSGIKSPIYIDIRTVFSIHSLMRSIADQICNLIQDKKLVYDHIVGVPYGALPFATQVCVTLNRPLLLYRKEIKKHGLAKRIEGVYRKGDKVLVIEDVVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCW6</accession>
    <name>A0A0N4UCW6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ell-associated factor Eaf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8930</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCW6"/>
    <dbReference type="STRING" id="318479.A0A0N4UCW6"/>
    <dbReference type="WBParaSite" id="DME_0000513101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000513101-mRNA-1"/>
        <property type="gene ID" value="DME_0000513101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000513101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="28575" checksum="9D812E14F8695CF9" modified="2015-12-09" version="1">MAEACEIPTGSYTLKLGSTFSIHANDTSYHTLRFDFKPKSLACEKDTYIGFGGGGDVQIAVHNNDDDSLTIYKGSQKPVKAFKECLLFFDHTSGEFRLEKLSTVISVKKTRDTGESDVSQLRVEIDKLRQKNELSTAMNGKSITNSSKRSRSSSSSSSSSSNSESEDSDESSARILNNRVATDSSPSSSDGGSSGKSSGDDDDDDDDDDDALETALEQLNNNHFMDAVENSSKNDASSILNHQNNSKKILHDDLHLSESSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD15</accession>
    <name>A0A0N4UD15_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8987</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD15"/>
    <dbReference type="STRING" id="318479.A0A0N4UD15"/>
    <dbReference type="WBParaSite" id="DME_0000518801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000518801-mRNA-1"/>
        <property type="gene ID" value="DME_0000518801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="11">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000518801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57771" checksum="A033C37FFEF93DC2" modified="2015-12-09" version="1">MQNVVKEGSMVIWDYHVILIRNMHGRKYVYDLNTKLDFPCDLKTYWSQTFRPDIAIDSKYRRYFRVFSALEYLKKFSSDRRHMKNAKGEFISCPPQWPAIYKEVASIRLFYNTCNLSNLNDNKTQLITTPLQRFCIEQKKRDLIAFAHPSQIVDANFQLINNLPNFFIGFDPTSNSLHIGNLLILTSLLRSIQFGCQAIVLIGSSTASVGDPSGRQIERDFLESDTIRLNAIQIHSQISHIFSNFSEMYPNIAYKLEIVDNMEWYSKIGGSDQLGHLDIGCDYIMRRSGKNSAGLCLPLLTDAAGNKLGKSLSNIGGNIWLNERKTSSYAFYQFFQQKPDKEIVALFRQFSLRPFEEIEAILVHHSNNLGQWIAQKELATELTRLVHGQRGLEIAEQCSNAIFHDNLDGLLNLPASTIENLFGEASSFHLSRSKIKNFGDLANQCRRDKFYGSVLMKEGALKLNGKRYTDPKRSIDFSEINFGGKNLTIVCWGKRKYSLIRWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDB2</accession>
    <name>A0A0N4UDB2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9107</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDB2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDB2"/>
    <dbReference type="WBParaSite" id="DME_0000530801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000530801-mRNA-1"/>
        <property type="gene ID" value="DME_0000530801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000530801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33637" checksum="EEA30A2485A577F6" modified="2015-12-09" version="1">MGCCLPLSLIGKIDCKQSGVRAVRFNVDGNYCMTCGADKTVKLWNPYKQILLKIYTGTGWEILDAQSSSDNSSILAGGLDKQLTIFDVETGKITRRWRGHSGKVNCVAFNEESNVALSGSQDGIVRCFDVRDKSGPIQVLDEAADAVLSIDVCAHQIASGSADSNVRIYNIREGKMSMDFVGDSATSVTFSGDSQCILVSTKDGFVRLLDNNNGKLLADYTGHMNNEYRIESRILSTEAHVLSGSEDGKVYIWDLIHMSLLHRLVHPDRIIHSVSVHPTKPFFLSASSSTIFFWGISETETVIKANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDN9</accession>
    <name>A0A0N4UDN9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS563</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDN9"/>
    <dbReference type="WBParaSite" id="DME_0000545701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000545701-mRNA-1"/>
        <property type="gene ID" value="DME_0000545701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000545701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9575" checksum="979DE5D4C508460D" modified="2015-12-09" version="1">MTNGLMEQCQLLWDQSSLALKGVLKQTWKTVGGSMLQRKEKEIAPSVGDGFCTTLQTQNVQKEEERRGMTAGWGSWKLPFNISAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDW7</accession>
    <name>A0A0N4UDW7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9285</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDW7"/>
    <dbReference type="STRING" id="318479.A0A0N4UDW7"/>
    <dbReference type="WBParaSite" id="DME_0000554401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000554401-mRNA-1"/>
        <property type="gene ID" value="DME_0000554401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF46">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="120"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000554401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24160" checksum="4AE04FF0AF0F0AA0" modified="2015-12-09" version="1">MKFHSIVATPQVIAKIEQYKRDNPTIFAWEIRQRLIEEAVCEKPPSVSSINRILRTRAAERAATEFSTMFAVQQHIANVVNRAPFLSYPITAYRSMQSQDANLIINLEGQHESFRSANSKRSARSTFTPAQLKILENTFALTPYPTIAERMTLIKKTGLPEARIQVWFSNRRAKWRRFKQETSFETKDFLQKNSEDKKEVLTVFKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEI3</accession>
    <name>A0A0N4UEI3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UBR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS784</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UEI3"/>
    <dbReference type="WBParaSite" id="DME_0000579001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000579001-mRNA-1"/>
        <property type="gene ID" value="DME_0000579001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000579001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45228" checksum="3ED1F8BED96ADBFA" modified="2015-12-09" version="1">MSAEEEKNVGESETNIISEIHNDKNLPSKINSEKDSEVLTLDEVIEFYEDQQAEAQALLGGQDEKVCTYPEGYKDRQAIYSCRNCTRDSQSAGICYGCSIHCHENHDLVELYTKRYFCCDCGNSKFTTPCSLYKEKSLLNERNKYNHNFDGLYCECNRPYPCSEYDDSEMLQCCICEDWFHLEHLEDSPGSIEVNEVEEVICRGCVKKLDFVVLYADDMYKEPEDKNITCVKKWLEALIPKKPLRDYSLFFNSYDWRKRLCKCTSCMNLYEDLDVSFLTDMSDTMSAYVASQLQKSHLAAENINGRSRIVDAIVQKAGRDGAVELLRGYEDMKKKLVNHLKRLADEGRDISENDINEFFSELISQRKRRRIDSGNVDDGANNNNDNEGGEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UER7</accession>
    <name>A0A0N4UER7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9413</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UER7"/>
    <dbReference type="STRING" id="318479.A0A0N4UER7"/>
    <dbReference type="WBParaSite" id="DME_0000588901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000588901-mRNA-1"/>
        <property type="gene ID" value="DME_0000588901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000588901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14627" checksum="3668C24EAAB1BC80" modified="2015-12-09" version="1">MAGGKGKAGKDSGKSSKGKVISRSARSGLQFPVGRIHRFLKQRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLHLAIRGDEELDTLIKATIAGGGVIPHIHRYLMSKKGQPAPTQKPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEU7</accession>
    <name>A0A0N4UEU7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS861</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEU7"/>
    <dbReference type="STRING" id="318479.A0A0N4UEU7"/>
    <dbReference type="WBParaSite" id="DME_0000592201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000592201-mRNA-1"/>
        <property type="gene ID" value="DME_0000592201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EIF3F/CSN6-like C-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000592201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27456" checksum="BC10C8C250749E82" modified="2015-12-09" version="1">MDYLESLYGMFHKVAAREKIVGWYHTGPKLCQNDIVINEQLKRFTPNPLLVVIQAEPKDLGLPTEAYIEVQEVHDDGTPPIKTFEHVPSEIGAEEAEEVGVEHLLRDIKDQTAGTLSQRITDQLSGLCGLHGKLCEVRHYLKELVDGKLPINHAVIYYIQEVLNLLPNITSPQFVESHNMQTNDQLMCVYMGSLIRTVIALHNLIDNKLSLQKTEREKDMKKEEKSEEKKEVKEDKKSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFT3</accession>
    <name>A0A0N4UFT3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1211</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFT3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFT3"/>
    <dbReference type="WBParaSite" id="DME_0000631401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000631401-mRNA-1"/>
        <property type="gene ID" value="DME_0000631401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000631401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28718" checksum="6B9D03E0DC51AF31" modified="2015-12-09" version="1">MKLNIAYPATGCQKVLDIDDDKKLRIFYDKRMAQEVEADALGDEWKGYILRITGGNDKEGFPMKQGVLTNSRVRLLLSKGQKCYRQRRDGERKRKSVRGCIVDANLSALALVVVKKGEKEIEGLTDTSIPKRLGPKRTSKIRKLFNLSKNDDVRKYVIRRILPQKNGKKPKSKAPKIQRLVTPVKMQRKRHRIAMKIKRSAKRKEEEAQYQKLLTLYTKEKMAEKLARRRSSASHRDSESTRHNRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG05</accession>
    <name>A0A0N4UG05_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS9508</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG05"/>
    <dbReference type="STRING" id="318479.A0A0N4UG05"/>
    <dbReference type="WBParaSite" id="DME_0000639701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000639701-mRNA-1"/>
        <property type="gene ID" value="DME_0000639701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000021">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="16">
        <location>
            <begin position="30"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="179"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="432"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="533"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="662"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="792"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="1075"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN59535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000639701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1165" mass="132618" checksum="500E9178BBF539A4" modified="2016-06-08" version="2">MNGNNEDLSKSIKSLQDKWRLVPAFLQVRGLVKQHIASFDYFVNEDIKKIMRANQRVLCDSNPSFYLKYVDIRVGMPSSEEGFNDINSKITPHECRLRNMTYSAPIMVDVEYSRGNQRVLRTGLVIGKMPIMLRSSRCILRNKTEAQLAKVQECPHDPGGYFIIRGSEKVVLIQEQLSKNRIMINRNSKKELQCEVLSSTADRKSKTYVISKKQRYYLRHNHLTEDIPVAIIFKAMGFESDKDIVSAVGIEEEIISAFAPSLEEYVNCQVCNQETALKYITSRIKVRKFGSSAGLPIQDLETIDFLSNLMICHVPSKAGDMKMKAIYLGLMVRRLIQAEMGHIECDDRDFYGNKRLELAGSLMALLFEDVFKRFNTELKRIADSNLGKTRAAPMDIVKNMRQDLITNALVDALATGNWIIKRFKMERHGVTQILSRLSYISVLGMMTRINSTFEKTRKVSGPRSLQPSQWGMLCPSDTPEGESCGLVKNLALISHITTDSDEKPVLRLLFSAGVENIQLLPFGEIHKRENYTVFLNGVIVGMTKKPQHIVDTIRSVRRRGILNEFVSVSTNSLLRSVHIASDGGRLCRPYIIVTHSQPHVTQEHINQLKRHHRIFEDFIDDGLIEYLDVNEMNDASIAVYEEDIKPYTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGSIGYNQQKRIESLMYLLVYPQRPLVKTKTIEFCNLEKLPAGQNAIIAVMSYSGYDIEDALVLNKASLDRGFRFKIDLKIRLIRWSKKLYFLYFHLCFNSYSLKIVYSGYGRCLVYRNAVATARKYPNQTFDRLMGPTLDATTRQPIFKHRVLDQEGIVYVGARIMPKQVMINKHMPVVHNEGENEVINPRNVEYRDVSVVLRQPLPYYAERVLLTYNDDDAHLIKVLLRQTRRPELGDKFSSRHGQKGVCGLIAQQEDMPFNDLGICPDLIMNPHGYPSRMTVGKLMELLSGKNAILTGKFHYGTAFGGDKVADVCEELAARGFNYLGKDMLTSGITGQPLSAYIYFGPIYYQKLKHMVLDKMHSRARGPRAILTRQPTEGRAHDGGLRLGEMERDCLIAYGASMLLIERLMVSSDEFKVDVCAKCGLIGSKAWCQMCRSSRNLATIKIPYACKLLFQELQSMNIIPKINLKKYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG51</accession>
    <name>A0A0N4UG51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9561</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG51"/>
    <dbReference type="STRING" id="318479.A0A0N4UG51"/>
    <dbReference type="WBParaSite" id="DME_0000645001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000645001-mRNA-1"/>
        <property type="gene ID" value="DME_0000645001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23803">
        <property type="entry name" value="UBCc_UBE2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000645001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27219" checksum="55A867AA57E36F7A" modified="2015-12-09" version="1">MNSVIEKGTNATSTISNAGAVRALSLELKSLQKSPIEGFTVTASDDNIFVWTVGIFGPPGTLYQGGYFKAIIKFPANYPYSPPTIKFTNKVWHPNVYESGDLCISILHPPVDDPHSGELACERWNPTQNVRTILLSVISLLNEPNTSSPANVDASVMYRRWVDTGGKDDEYATIVRNQVDSSRIEAEKDGVVVPETLEEYCVKTIAKPNDEIEVFDLDEDYYDYGDESDDDNEYDENGEDSGQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH55</accession>
    <name>A0A0N4UH55_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatase tensin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1472</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH55"/>
    <dbReference type="STRING" id="318479.A0A0N4UH55"/>
    <dbReference type="WBParaSite" id="DME_0000685801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000685801-mRNA-1"/>
        <property type="gene ID" value="DME_0000685801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000685801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71024" checksum="950C436C768502ED" modified="2015-12-09" version="1">MSLEDLPLSLNNQRISVEDNSEELKLSIGKDPLTTSRTPVLEVNSPAQNSFSSFSSVSLKTSNMICKPWRTMVSQNRRRYKIGNFDLDLTYITDRIIAMGFPAIDQEKIYRNSMEATVQFLEYYHAGHYMVFNLRGNHIYDPGYFHNRVMTFEMNDHHPPRLELMAPFCHAVHEYLQANDQNVVAVHCKAGKGRTGVMICAYLVYINFYLSPRQNMDYYSIVRTVNNKGVTIPSQRRYVYYFSHLRKRGLNYVPLLSELIGVYFERPPKFSGLLFKGAFCLRVANGRIDVFNPDPIYMSKKEMIDEDEIWKTHNCSFGSDYDECDNTEFGSNCISRRCYGWTVPGSKRVFLEGDVRVDLYVKKFVKSIGLSAGREKLGHVWFNTMFSCPNFCGGAYIHGDEAYPYPEKGTTIVNHWPRCSERRSSSQLSPSVCKRLNTVMDDFINDNQTAMGTCLNKCKSNLGIVSYFSLELFGNKFRTSFHVVFSAQSSSSLISGEDLLPQSDIELPPGLDSHCPSHCLPLIYPEQLGRRPPRAEIIMMLRNAHINGLIKDSYNQRRLAANTDGVPVPKAKPGRPPSGGPFCLMQGSDEHVVTFNALEIDRAFKNEKIHSGFKVNSFFRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH73</accession>
    <name>A0A0N4UH73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deacetylase sirtuin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1492</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH73"/>
    <dbReference type="STRING" id="318479.A0A0N4UH73"/>
    <dbReference type="WBParaSite" id="DME_0000687801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000687801-mRNA-1"/>
        <property type="gene ID" value="DME_0000687801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000687801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36682" checksum="37CC0EFAA0EBED53" modified="2015-12-09" version="1">MRLLSFTVKPIAEANHILLLHSDSVNFIELAEGKKQILSSISMEGIAEYIKDKAKNIIVMCGAGISTSAGVPDFRTPGTGLYDNLAEYNLPYPMAVFDLEFFKTKPEPFFLLAKKLFTKSLKPTYCHYFIRLLHEKGLLLRLFTQNIDLLENVAGISADKVVTAHGSHCTSTCLSCGQKYDLKWISDKIYDEKCVVAYCDKCHGIVKPDIDFPKCDLLLIMGTSLTVHPFASLVHEVGNDVPRLLINLTEAGKQDASLNMMYSFGYRLAYGEDGNYRDVFWKGTCDDGVKRLAELLNWKDELYSLVEKEWKKINEENTKHAEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHH4</accession>
    <name>A0A0N4UHH4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9806</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHH4"/>
    <dbReference type="WBParaSite" id="DME_0000700701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000700701-mRNA-1"/>
        <property type="gene ID" value="DME_0000700701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF90">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="861"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="899"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="365"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000700701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="973" mass="110515" checksum="FEDE22ECC49C8FC6" modified="2016-06-08" version="2">MAATSGRHALINSPSESNSQAKLMNEHQIAVHVLAQSPKTANNRAKASELLEFCQMLTLKRLFRLIGFSIATYPLAYFIAAAIMTSLSGGIYFLKMEDRVRDGYTPTTSSSRYETDVLREFLQSVGDPTLTTVALRSRDGGSMHRLRHLKEAVRLHSFLMSNLTVNLSTPDQQITYDSICGSYCNTNVVIEYFYRALLDEINRYKMGKRKSQLMNLSYPIAKIEGFDVHLERSFYGVKLRQDHIQAAKRNTTVYSSESELQLLSNVTNIEYLYIILMIFRGDIPSVEMEAKLNAWELAVYNFATNDYSNPDVEMLVLGAEIVNHELIKDSQKMAPYFIAGFLAMFIFVAVTIIGSALFKGIMDPAKLIVAIGATVCPILAITVTFGLCALANLRTNTIMLIMPFLIMGIGVNDAFLLIHAWQRLSNDNIVRQRLGLVLEESGPSITISTLTNVISFGIGALTPTPEISLFCMATAMALGFAYIFTLVLFGPVLYLASIIEGKRKRTRNSSQVLSWVKTGLKIYCRVITHRIFGFALLIGSVIYWYFGIMGTFNINTRLDVQKLLPKNSPLQEANNVVSNFVWTEYYPVTVLINSPLDIREKSVMDDFIGMLSDFESMEKCRGQDFTLLWYRDYLVYWNQSILYDFDFYEDENAKITTVVPIVDSTKTGLDYSKLELFLRSPLYAHWNTFMKLGYFCNDTKMPVERFWFTVAYHNSSSWADRIELMENWREIAHSYPSLNATVWEANSMFVDQMLSLKMLTLQSAIWTFLCMTAVCILFIQNPISVITASMAILSIRVVGYLSWWHLDLDPATFCAVLMSIGMSVDFTAHISYHFQLNHKKEIRDGRIVKVGLKQNRERLEFTLGCVAWPMLQAGLSTVVCILPLIFLQNYIPLVFVKTISLVVIWGLFHGLVLLPAFLSLIPHFLIEINCYRAIFNQNWPNSRELVIREPLDEQSIVNYPVRADTCLLSVNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHI8</accession>
    <name>A0A0N4UHI8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1573</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHI8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHI8"/>
    <dbReference type="WBParaSite" id="DME_0000702101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000702101-mRNA-1"/>
        <property type="gene ID" value="DME_0000702101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000702101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34729" checksum="A5E2B409D809C3E1" modified="2015-12-09" version="1">MYHTLTSILANIAKSESERMDYEKKLSNDFVSLTKVLSRNVEHINDDRNAFFFQLIQISLEVINAYLKNTSCSERFVLSVCKALSFLINGKSFVYIAVPVLKTLGSLIRSMSGFSEEKLVRAELLSLILACLKWLVVCRDDINIKEFATAFISLLSLLKKQNELTSDLIESYSKILVTSAVTDLFAKAKQELFIAHPTSHDFEFISPFVQQILLKSATLCLFVLKELSTAIASQGYGSMAQFIILLSMINLTNASRPKLSFAPNSDEQKKFKQYLDVARSSLLEQLADFPINGENSNYLKQIENLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHK3</accession>
    <name>A0A0N4UHK3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHK3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHK3"/>
    <dbReference type="WBParaSite" id="DME_0000703801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000703801-mRNA-1"/>
        <property type="gene ID" value="DME_0000703801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5808636at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000703801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26064" checksum="DF7F0257AB8DB405" modified="2015-12-09" version="1">MSRNFQVDINHLSNAYYRIVQIRTDIVDKDSIRFDMHLISSGDFGDTLTITTQNGETRTISFPGCYRVNLSFRMVKPLSNPHIEAFLQLGTNIPCQPTNSNSISNICTNITQTNCRFCNLCEAIEAKSSEIQHYIRQEGSQECSTSKQSQNLIFKAGVLTAIVHILDRSQVDGSKLVQCQRLCSTFNNQKSVSDSYKSTLLKSIETLCSPVDIYTACIHHIMKFDISENFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHK4</accession>
    <name>A0A0N4UHK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1591</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHK4"/>
    <dbReference type="WBParaSite" id="DME_0000703901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000703901-mRNA-1"/>
        <property type="gene ID" value="DME_0000703901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000703901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8821" checksum="F22DA65C5D4FD9F8" modified="2015-12-09" version="1">MRTCNYYILRFISLTILGIVINDCLISASLNNRNDNKDTNELTTTQWADKIGIKAKQAVKKIGAVMKAEDSILECKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHM7</accession>
    <name>A0A0N4UHM7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9826</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001192">
        <property type="protein sequence ID" value="VDN59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHM7"/>
    <dbReference type="WBParaSite" id="DME_0000706501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000706501-mRNA-1"/>
        <property type="gene ID" value="DME_0000706501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000706501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24151" checksum="930C9440F74C7AB3" modified="2015-12-09" version="1">MKYHFKSIRFDFLVRFLFVKREKFPMKKILDLADKGKYDDDQTWSIHQSANRSIGQLVDPPVGQSVRQSVGRSASRPIGPSISWSIRQSANRSVNQLVDPPVGQSVRQLVGRFASLPIGPSVSWSNRQSANRSVDLDQANYCEKSLQSSHLRNETKFKNSRLSSLTMPETYNNTTNLQQKNRNISEWLKGLDGFNFIIPLISDSSVKDIDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ08</accession>
    <name>A0A0N4UJ08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1883</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ08"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ08"/>
    <dbReference type="WBParaSite" id="DME_0000761601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000761601-mRNA-1"/>
        <property type="gene ID" value="DME_0000761601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864015at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000761601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34068" checksum="8E840BC9EB51D6F1" modified="2015-12-09" version="1">MSAIIVKAVQPVKEKVLSLLEKIKKMDLEKMDPMMTPEEIQEQHETRKRIINEKMMRLESYLESLETTNKEWKQYIQQISSPQKRREEEEKYAQMVDDETGILRLISDSKDVIITLKMYEKDSEMLQRLEKSTEKGVLTRQNETIPSANHTTVNLPQLPLPIFDGNPKLWRGFWSSFDAAIHLQNILDIQKLNYLIACLKGDALQAVRGYDITPENYNVIRTVFVEKFGQSYIIKRSLYNELYSTKKNDREWRVTIESIERILRQLEAMGENLEQSSIEIIVESRLPAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI9</accession>
    <name>A0A0N4UJI9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10198</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI9"/>
    <dbReference type="WBParaSite" id="DME_0000782801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000782801-mRNA-1"/>
        <property type="gene ID" value="DME_0000782801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000782801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38120" checksum="5498AFCAA428AB83" modified="2015-12-09" version="1">MIFSGTSTHCITFEVAELSVESKAAAKSIMQLTVGCWYLKPYSKIFLSVNIWSAQSHPGLNPACNLHHICHCEWSPVNDRICAISSKSSFSAFDPETSLDDRCLISVKGFSYFNWNRYNYLIGLSGENGTCIMDMRRFDERQFLDCTPSTSVQWVVDSDHLIFSASNTNELYLFDTRNGHRFKHLNIQLKSKVLCIRCSNDGLFVACLCQRELCIYRTHNMQLYSRIKLGPKTRDFDVVKFDLYSENGDLRLFLPHGKKIEIISLLGDEGYFVRDWETDSDCNFVIYNSDNNHIFALGSEISQWIPKTDYPCNEMTKYSFLELDSWSDNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJK6</accession>
    <name>A0A0N4UJK6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1999</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJK6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJK6"/>
    <dbReference type="WBParaSite" id="DME_0000784801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000784801-mRNA-1"/>
        <property type="gene ID" value="DME_0000784801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979394at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047620">
        <property type="term" value="F:acylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="113"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000784801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55436" checksum="15F81EA15D794C30" modified="2015-12-09" version="1">MKDDGLCASCYSKDKVGVTGCGGKVGRENHLATDRPFNELKKLENRFIMRKLPGKIKDCGKFFWTHKKKVGVSVVALYYAQQFFWSWKRNCDIRTIYANKALQYGFTPEVSVLPSRRVAVLVNTHAGGGRTFNSFKTYALPLLNLAGLHVDIIETENKAQLKAVAESLDSKEADVLYIVGGDGTVSDVLSAIYNSEKNAELPIGIFPAGKENYSLVNLSPFVFSDQNDVRSFCESAMAIIEGKIKTIHIAKFFLEKNNSKESDDKARYGLSNFHAGWYEYIERRKEKLWYWGNLKRRISYIWEMIKNYPTDLKILLVYENFCEGCKKCLQPVRNDSNKWWFSFLGMRKKTKTLPEKYSTNNEICGVKNELFVSTNDFLIELLQHDDTSKLHIRMSGSDVGRSGIIKEGWSRCRNNTKANSPNQFYENDLLAKNVKIIFKSFPEKMGTFKIYGQDIKIDANQIYHFETTNKKIEIYLPEIFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJM9</accession>
    <name>A0A0N4UJM9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zf-Tim10_DDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10222</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJM9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJM9"/>
    <dbReference type="WBParaSite" id="DME_0000787301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000787301-mRNA-1"/>
        <property type="gene ID" value="DME_0000787301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000787301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21919" checksum="C687150A9797CE19" modified="2015-12-09" version="1">MYLTLKTNPEDRTRRKRQYDCSFVLGKTIKFCEDMGQRQSENRQYVDQESKALWEVEMEMMSDLFKRLSNSCHQKEAELTKGETVCLDRCVSKFMDLHQRLGQKLTAITRAEEQQLQSQMIQQQQQQHEQQLKSNCFNVELASVLNYHGEVKKVLLSSLKEHDAILWWIIKEVSANLLIKYGAQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJS7</accession>
    <name>A0A0N4UJS7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2055</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJS7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJS7"/>
    <dbReference type="WBParaSite" id="DME_0000793001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000793001-mRNA-1"/>
        <property type="gene ID" value="DME_0000793001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="121"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000793001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="57428" checksum="079231CFAD443550" modified="2016-06-08" version="3">MYFIGVRSINSLHSEQLVEFRKKFNETSLLCDKKKKARTYIACSQLIIYFKLNFQQSNFFFQHFVPLYSEFEALYARNCYNRVRDIFERPISSAAGARIKILDRYSNNFGWTFSYTGTTTEVINVGSYNYLGFAENTGPCASAAATAIDEEGISNCTVIHEQGYSKTQWELEKLLAKFLKVEDAICFSMGFATNSVNISCLANKDSLILSDQYNHASLILGCRMSGATVRIFKHNDVVDLERILRESIVYGNSRTYKPFKKIIIIIEGIYSMEGSICDLPAIIALKKKYNAYLYLDEAHSIGAMGADGSGIVNYWECDPNDVDILMGTFTKSFGSAGGYIAGRKRTIDYIRVNSPAGTYSSPMSPPVAKQIYSSLSIMMGLDGTNDGKNFFHKPKNYYLFDLKTLVMNTRYFRKRLKQMGFIVYGSDDSPVVPIMIYYPTKCGLWGREMLKRHVGAVVVSAPATDMAESRVRICLSASHTKEMLDIVLEAIEEVGILSNALYSRKKYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJV9</accession>
    <name>A0A0N4UJV9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2094</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJV9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJV9"/>
    <dbReference type="WBParaSite" id="DME_0000796901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000796901-mRNA-1"/>
        <property type="gene ID" value="DME_0000796901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="3"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000796901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30480" checksum="A5DD019159865F07" modified="2015-12-09" version="1">MFRYFKESGKESIVLNAFVRILTTITYALNSFQIGIVGRTGAGKSSLLRALFRLTEPEGQIFIDGVDTKTISLRDLRKRISIIPQDPVLFLGSLRRNLDPFSEYSDENLWNVIDAVELKNVVSDLPTGLETEMHEGGVNFSVGQRQLICLARALLRHSKIIVIDEATANVDRKQVSIFFVVFTLTDALIQSTIKNRFVESTVLTIAHRLNTIMDSDRVMVLSYGELIEFDHPHVLLKQKNSMFGTLVAETGRENAELLKQLAYTSYISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK60</accession>
    <name>A0A0N4UK60_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2212</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK60"/>
    <dbReference type="STRING" id="318479.A0A0N4UK60"/>
    <dbReference type="WBParaSite" id="DME_0000808701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000808701-mRNA-1"/>
        <property type="gene ID" value="DME_0000808701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000808701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27803" checksum="1B3B11A1EC9A80AA" modified="2015-12-09" version="1">MGNYNLQIVTGGTDGIGKAYLIELARRGLRKFVVIGRNQNKLDNVKSYLELEFGANVRTYLFDFSTGNYEQLRNYIEDIDVGFVVNSVGVGRELMEKYGENPSADREILKVNGLGSAEFLSIALATMDKCGGGQIIVISSSQGYRPIPYLASYCASKSLLSFLCEAANRERAKINVQCLTPALVATNMTFYKEGSLFVKTAEDFVQEAINTIGIVTKTTGCFNHEMQVMKNDSNCMAKNLWNAKLISRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKK8</accession>
    <name>A0A0N4UKK8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M4_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKK8"/>
    <dbReference type="WBParaSite" id="DME_0000828001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000828001-mRNA-1"/>
        <property type="gene ID" value="DME_0000828001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000828001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7865" checksum="BF20670059090AE3" modified="2015-12-09" version="1">MLGHTSRECSSWVSGAVVQLFENKYRADPDYRMNYNWETISEMVRDSDDAPVKDIKDRSYGGRNFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL43</accession>
    <name>A0A0N4UL43_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2472</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL43"/>
    <dbReference type="STRING" id="318479.A0A0N4UL43"/>
    <dbReference type="WBParaSite" id="DME_0000849701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000849701-mRNA-1"/>
        <property type="gene ID" value="DME_0000849701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041121261" description="tryptophan--tRNA ligase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000849701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44789" checksum="6605DCC9952A94B3" modified="2015-12-09" version="1">MDLDIHFLLLLLLFSMANEYKMNPKIFLRFLMFGNYYCKKSLEQKFRKFGSFNTAKFPVVYFSGIQPTGVLHLGNYFGLVEPWINIQNSQPPANELFLSIVDYHAVSTGFLPREKLRSNIMKMAAALIACGVDPERSILFQQSAVSEHTNLMFIFGSIATVARLQKLSQYKDKSRKFKMGDVPTGLQIYPLLQAADILLYKATDVPVGQDQIQHLELTRDIAKNFNAAVQTNFFPIPNQVVPDFPRIRSLRDPTKKMSKSDFDTRSRLDISDSSKIILERCQKALSDMQSNITYDPENRPAISSLINLYSALTKQSQQDIINECSELDTKGFKEKLAKAIDHHFAPIREKYEALMSHDSDHLCEILEYGRQRAQKVALQNMAELKDLLGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL76</accession>
    <name>A0A0N4UL76_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10401</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL76"/>
    <dbReference type="WBParaSite" id="DME_0000853401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000853401-mRNA-1"/>
        <property type="gene ID" value="DME_0000853401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875379at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000853401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29112" checksum="121E7AAFB29ED610" modified="2015-12-09" version="1">MIAGFGRLFIIFTNTTSLSSMRQCAMIPWNVLQIWAEPLSAMVLLIISVDRLSSLVCPLKYRKYGRHFQVCQVSIAMVIVASLVLPSWIHSWGEVALEHSPMCWYVETASGIAPEFNTIFFVIRIVCSSASVVVYAIVWTISRRYFSERMTKNSNSAQYLKIQRRLTVTMGIWGIFTLILYVLPVIITSITNSLHLEVLNEFATLLLTFTSNINPVVDLTVLLWRQPDINGAVAKIVPFVKMFRRNSVADKSLKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULN4</accession>
    <name>A0A0N4ULN4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS10448</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULN4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULN4"/>
    <dbReference type="WBParaSite" id="DME_0000871501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000871501-mRNA-1"/>
        <property type="gene ID" value="DME_0000871501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000207">
        <property type="entry name" value="serine/threonine-protein kinase dst1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="14"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="292"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000871501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="62994" checksum="E97AAC2E6714E024" modified="2015-12-09" version="1">MLKFARKLDPEQLFTRQERIGRGSFGEVYKGIDNRSGQVVAIKIIDLEQAEDEIEDIQQEIMVLSQCDSPYVTKYYGSYLKGSKLWIIMEYLGGGSALDLTKSGKLEEMHIAVILREILRGLEYLHSERKIHRDIKAANVLLSESGDVKVADFGVAGQLTETVKKRITFVGTPFWMAPEVIKQASYDFKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNAPPQLNGSNWSRAFKEFVEICLNKDPENVGFPRPSAKELLKHPFIRRAKKNSVLIELIERSVEYKLRIGPSSDSDQDDDNDAANGEVPWEFSTVRTSSAKTNQDDDNQNTVRIKLSCNNRPTVISQGSPKSDISPDGTIVNRNNDSRISQIASELRQTSFRSYGVSNQPSGSSYQNFPSSVIPNGVSIGDHIMNATTISVASPTSSPTSSLNRTSSIAVGYSPQQSSQNHVRHTSNIATNGVQALSSHHFVNSQVSRLTSSHVHEPQRYKGALEYTLLPALKKLARTRHSGADLEAVATALKQAEKSSPGICDQLIIELLTTIALPQTTENELQMAIDRLTTRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULS1</accession>
    <name>A0A0N4ULS1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1501 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULS1"/>
    <dbReference type="WBParaSite" id="DME_0000875901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000875901-mRNA-1"/>
        <property type="gene ID" value="DME_0000875901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000875901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4794" checksum="7C3FA62C96314253" modified="2015-12-09" version="1">YQYFQSLSAPQDHISKRNNAELVNHILKNLGGLDRLGDVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT8</accession>
    <name>A0A0N4ULT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4ULT8"/>
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        <property type="gene ID" value="DME_0000877901"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000877901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20951" checksum="7B0CAB9F1D8D9C22" modified="2015-12-09" version="1">MILELPGVKIRLTKWGAEEVKNVGVKVLGEEISQLKGFRFLHSFAERGIVGRVLLYDVMVLHYSPPQFDSLNFYPPSYVILQLERMDIALFFLFFRTLYRDYRLTGRFVSDVGLITTSGSVVGEIRQMSVKLTTDFKAAPDGLMQVKVNAEHIVVECANNIAYSHFSINVDGPLSGLIRMIEVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM11</accession>
    <name>A0A0N4UM11_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2722</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000076">
        <property type="protein sequence ID" value="VDN52749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM11"/>
    <dbReference type="STRING" id="318479.A0A0N4UM11"/>
    <dbReference type="WBParaSite" id="DME_0000886201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000886201-mRNA-1"/>
        <property type="gene ID" value="DME_0000886201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017393at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF6">
        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000886201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44870" checksum="544877E700A13921" modified="2015-12-09" version="1">MVNLLQIILCQELELWLNEPRFEVNWLRQQIVPCHDREPSYLSTDTSGINAMLNHEDVSEYLKIGTNGLEARCDASSFESVRCTFEAVDGVWFYEALILTAGVMQIGFATKQSRFCNHEGYGIGDDEYSLAYDGCRQLLWHNAQFEKHEHKPWNAGDYLGCLLDIPGCFVQFYLNGQPLQNPHRKFMERRMTNFDSGIFAAASFMSFQQCRFNFGHHPFRYPPLNIEFKTFNEYGVLTEEQKTILPRRAKMELISNMIISDENCHICYTDSMDTVLEPCGHGAICFHCSNQIRQCPLCRVDISGRVRIAKKQSVISLERSFTYLMGMNSNEPISTMEHTIDETNFLAAISHYRIVISTKYGEITIAIFITQIFSWEITGPEEAARNCNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMB6</accession>
    <name>A0A0N4UMB6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10532</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001223">
        <property type="protein sequence ID" value="VDN60559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMB6"/>
    <dbReference type="STRING" id="318479.A0A0N4UMB6"/>
    <dbReference type="WBParaSite" id="DME_0000898101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000898101-mRNA-1"/>
        <property type="gene ID" value="DME_0000898101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000898101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12634" checksum="7DE8FF892DE1549E" modified="2015-12-09" version="1">MTKGTSSFGKRHNKTHTLCRRCGRSSYHIQKHRCASCGYPAKRKRTFQWSVKSIRRRTTGTGRMRHLKVVHRRFRQLSLVNYRNGFREGTIPKSKSRGANQKVDAVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN96</accession>
    <name>A0A0N4UN96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HABP4_PAI-RBP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3079</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000103">
        <property type="protein sequence ID" value="VDN53106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN96"/>
    <dbReference type="STRING" id="318479.A0A0N4UN96"/>
    <dbReference type="WBParaSite" id="DME_0000936801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000936801-mRNA-1"/>
        <property type="gene ID" value="DME_0000936801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022699at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="168"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000936801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41046" checksum="524F107BE426A0CB" modified="2015-12-09" version="1">MVEYGVIVTNKFGTLNDDENEDPEVILKKAEAASKKEEKTASQKKADRHAAARKKKETAALKAAVSELEKKKATLIKAPISDVFAERFGEFRGRPRIRGFRGGNRGGFRRGGFRTGNDEQLIDPNVTVNGIQNGENAIEAIDRGSIRTASYGGGFGGRANFRRRFLRGGRQSDRTNDEIRTTGLSFEKRDSLNKANEGAGREETIEDIENNTPEDEKMRKENIVLNEKNEEEQRTEMENDVTVKQLTLDEFKAQTAAKRSEPQFNIRKAGEGANEKEFGKLIPLPKREIVEEPVDEIVVVRREPRTKRLDIEINFTDEQRGRGGGRVRDGFRGGRSHRSGRGDGRGFRQNLNFEVSADAFPALGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP01</accession>
    <name>A0A0N4UP01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal_S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10719</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001239">
        <property type="protein sequence ID" value="VDN60746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP01"/>
    <dbReference type="STRING" id="318479.A0A0N4UP01"/>
    <dbReference type="WBParaSite" id="DME_0000966701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000966701-mRNA-1"/>
        <property type="gene ID" value="DME_0000966701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000966701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19460" checksum="F2A5C1403A9BCFA3" modified="2015-12-09" version="1">MRCIVVDYIAVKGKYAKYLPHSAGRYQVKRFRKATCPIVERLVSSMMMHGRNNGKKLMAVRIVKHAFEIIHLLSGENPVQVLVNAVINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPH9</accession>
    <name>A0A0N4UPH9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3447</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000134">
        <property type="protein sequence ID" value="VDN53474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPH9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPH9"/>
    <dbReference type="WBParaSite" id="DME_0000986601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000986601-mRNA-1"/>
        <property type="gene ID" value="DME_0000986601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="241"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000986601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56832" checksum="B62ECF25E3182955" modified="2015-12-09" version="1">MPESNSRVNSILILVGKELLNPKLSKLLPAPLPFELILVVLAVICSYSLKLEETYNVKVVGTIQAGLPRAELPNSELILYVIEDAIEIAFVIVAVHLSMCKIFSRRYNYKTDNNQELFAIGIAGVISSIFLTYPVSSALGRSTVNAESGCKTQCILAVIIIFSLKNIFRKAEELNELWIVSKWDFAIWMVSFFSTVATDVMWGLSISVAFALLTVIFRTQWPNWYILSQLTGTNDYRDCGRYGRVAEIDSIRIFRFDAPLLFTNVDHFRDAADKATFCPEKCIAALDHILQVRTVNKVKKIQKKRRLRKSFSESSETGIYGSKKNVRHLIVDCSGFTFIDIMSIRSLIELFKNMDKDGIHTYFAGIKAPIRDMLDKFGFYNFVSNEYFYPTINDAVQCALMKEEIRRCRNIVRKKMLLNRLSKPAFVKEMDQYLMDETKLNSAMSPVGINRRMLKVLYKPILKNLNEITNKNLTKSEEIHTQNEQKIPETEFYKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPQ9</accession>
    <name>A0A0N4UPQ9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3509</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14 6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="UYYG01000142">
        <property type="protein sequence ID" value="VDN53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPQ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPQ9"/>
    <dbReference type="WBParaSite" id="DME_0000995801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995801-mRNA-1"/>
        <property type="gene ID" value="DME_0000995801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000052">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="152"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40740" checksum="73DE8A56355CD4AA" modified="2015-12-09" version="1">FPHFQPFLTKEEEERIFLEYSYTGATTNIHPLLSMLVNYTHPVKFSGFDVAEMNNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQLSRIYPKGARVDSSNFLPQIFWNAGCQMVALNFQTPDVPMQLNHGKFEYNGGCGYLLKPDFMRRPDRTFDPFSESPVDGVIAAHCSVKVISGHFLSDKKVGTYVEVEMYGLPTDTIRKEHRTRTVPANGLNPIYNSDPFVFRKVVLPELAILRFAVYDENGKQIGQRILPLDGLQAGYRHITLRTESNFSMVLPALFVRIVIKTYVPDELSGLVDALADPRAYLSAQEKRKEALHNMGVDEADIVEIPINKATSFATAKSNLLRLNGTSNILSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPW1</accession>
    <name>A0A0N4UPW1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000149">
        <property type="protein sequence ID" value="VDN53582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPW1"/>
    <dbReference type="WBParaSite" id="DME_0001002001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001002001-mRNA-1"/>
        <property type="gene ID" value="DME_0001002001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001002001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17962" checksum="5895A5E71EE63371" modified="2015-12-09" version="1">MDIACQHSRDVQINTVHSIADHQYVDDIVLFTDSYDEMQIMLNNMSTIAAIMGLRIQVSNIHRRSAVAILFNVSMKDLSRKYEHSDYDGAKYSAQSLLNASNVKQENELLTNGGLSEMNPSVGRKDTDVHLSSENDVFIRVSTLSNKRRIEEENNEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPW3</accession>
    <name>A0A0N4UPW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3557</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000149">
        <property type="protein sequence ID" value="VDN53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPW3"/>
    <dbReference type="WBParaSite" id="DME_0001002201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001002201-mRNA-1"/>
        <property type="gene ID" value="DME_0001002201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001002201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29755" checksum="A1BC29F0BEE1D722" modified="2015-12-09" version="1">MANNRKHIAKNLRSSFFFVHFRLSMRSVERMIMEAFILLIIIESILYIGLGLGKIPSENHEINEEIFNERQTKIVEQGAKLAEAVPHFSNIIFYKLTAITKAMDNFRIRRQLYCDSCFTEDREATALNALRKWLHETAEKIGATEEKINKKLVTVNELKRLASDQQIMMLQNYYFLLLWCSAIISLKSLEWLALFTFATSNFHYPSYIQQEFGSLIFYLRADYHPEIRIEIRKRNIIFLVYEREFSPCYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ17</accession>
    <name>A0A0N4UQ17_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3603</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000155">
        <property type="protein sequence ID" value="VDN53630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ17"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ17"/>
    <dbReference type="WBParaSite" id="DME_0001008101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001008101-mRNA-1"/>
        <property type="gene ID" value="DME_0001008101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001008101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18161" checksum="89DB6452F0677770" modified="2015-12-09" version="1">MQSAKNQLYEDDVLNNNSNVNNTSDDYSISSSSSQELKFSVQNILDPLFGKHEKSPKESSSMAQENIGIPFPAWIYCTRYSDRPSSGPRSRRTKRKSSSMSEDEKRPRTAFTAGQLERLKQQFMDNRYLTEKRRQELAHELGLNESQIKIWFQFNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQC1</accession>
    <name>A0A0N4UQC1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3711</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000172">
        <property type="protein sequence ID" value="VDN53738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQC1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQC1"/>
    <dbReference type="WBParaSite" id="DME_0001020101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001020101-mRNA-1"/>
        <property type="gene ID" value="DME_0001020101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866837at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039253" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001020101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8874" checksum="02974FA64A4EBEC6" modified="2015-12-09" version="1">MAKSWVALFTCFTTRAVHLELADDLSAESFLTALRRFVARRGCPELILSDNASQFHLVYRTIKKQESQLKKPLVENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQD3</accession>
    <name>A0A0N4UQD3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">39S ribosomal protein L39, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3723</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000174">
        <property type="protein sequence ID" value="VDN53750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQD3"/>
    <dbReference type="STRING" id="318479.A0A0N4UQD3"/>
    <dbReference type="WBParaSite" id="DME_0001021601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001021601-mRNA-1"/>
        <property type="gene ID" value="DME_0001021601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870821at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001021601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36886" checksum="69A8F68FB3691926" modified="2015-12-09" version="1">MLCRAIFRSHIYHATTRVSYNTTRNLDYRRRRLEVFDAEKKRQLQNISVKKVCIKVFGNDGESKVLLMNDGISSYFDCMRHMSRLKAERTALVRLLNKSEDAFFSVHDRINGDSEIELLGFNNMIYYDYVNKAYWRTCAYILGAIIENSFRNQVHLIRPESLDYKSGRFAYRVEIEDLNGWKASQLVNQLVFLKDDLAVLSLCISEFISRKLPFESLRVTRQVAAIIFRDNKWKIESLEEEDEELFVFKLGNHVDICDGPLINNSSQIGKFAVTKVDYEESCLCFYGVSLPAEQKCTSYTWDLLVAASRQSEENYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQE5</accession>
    <name>A0A0N4UQE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF5600 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3735</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000176">
        <property type="protein sequence ID" value="VDN53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UQE5"/>
    <dbReference type="WBParaSite" id="DME_0001023001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001023001-mRNA-1"/>
        <property type="gene ID" value="DME_0001023001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5600" evidence="3">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001023001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="508" mass="59186" checksum="0A802F1372E8B409" modified="2015-12-09" version="1">MLMKAYENKIRPIEIRHLWSSFNSLPLQTAELNSKPTLLFIGQYSAGKTSMISYLLHGLYPGAVIAPEPSTDFFTHITYSEEVQTLPGPTLVADKNYQFQILNKFGDTFLNKFRCVKFKAELLKYISIIDTPGILSSDRQISTRGYDLVEVTKTLASKVDRIYVIFDVNKIDISHECAKIIEILEGCKEKIKFILNKADSISEYELLRVKTSLIWSLGGIMKCREVPDIFVGSFWPYLMRKGRSDELVQEELLQDIKDIPNSFELNRINDVVRRVKKLRIHTYIMDEIIRQYFFFKYRKNLTKTATTPNELMPIFERISKKYQITKNDLPNPKEFHEKAKQTESINWNKIDAKLNRLLESFLDEDIAAITVKACRETRLNIEYKLPEKKLITIEVDLTDLKKNMDIKVQQDIISPIAISAICDKNESVKSKNKFINEKQFKKECKEENNRENVKKEGEDNEGNKKDIKSAIRKKMAIINEKEEEKEYKGSKGESKEERNSEKIKEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQH8</accession>
    <name>A0A0N4UQH8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3766</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000182">
        <property type="protein sequence ID" value="VDN53793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UQH8"/>
    <dbReference type="WBParaSite" id="DME_0001026501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001026501-mRNA-1"/>
        <property type="gene ID" value="DME_0001026501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="142"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0001026501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="46789" checksum="F395D5A831721693" modified="2015-12-09" version="1">MPIHRIHARQIYDSRGNPTVEVDLSTEKGVFRAAVPSGASTGVHEALELRDLDKNVHHGKGVLRAVANINAKIGPAIVSKNFCPTQQAEIDKFMLELDGTENKSNLGANAILGVSLAVAKAGAVHKGMPLYRYIAELAGVSQVVLPVPAFNVINGGSHAGNKLAMQEFMLLPVGAKSFSEAMRMGSEIYHCLKAEIKKRYGLDATAVGDEGGFAPNIQDNREGLDLLNTSIALAGYTGKVSIGMDVAASEFYKYDLDFKNPNSDKSLWKTGDEMAELYQSFIREYPVVSIEDAFDQDDWTNWTKLKANTNIQLVGDDLTVTNPKRIMKAIEEKACNCLLLKVNQIGSVTESIEAAKLSRSNGWGVMVSHRSGETEDTFIADLVVGLATGQIKTGAPCRSERLAKYNQLLRIEEELGAAAVYAGEKFRNPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQT3</accession>
    <name>A0A0N4UQT3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3858</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000203">
        <property type="protein sequence ID" value="VDN53885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQT3"/>
    <dbReference type="STRING" id="318479.A0A0N4UQT3"/>
    <dbReference type="WBParaSite" id="DME_0001038801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001038801-mRNA-1"/>
        <property type="gene ID" value="DME_0001038801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533763at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001038801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17133" checksum="CE3CCF9E4B51FF05" modified="2015-12-09" version="1">MNAKKILEHKRAKDREYEDKESKRKKEFAESRQKRQREAAEAEISSDMGAHGSPKGMEEIFSDPEILTLLKDKEVLKAYSDILEHPENLAKHMTNENVRKLLDKMRKFKGFPQPEDASKIFKHGQAEEAKTADSAFAKPPPKMPEPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR22</accession>
    <name>A0A0N4UR22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10907</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001273">
        <property type="protein sequence ID" value="VDN60934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR22"/>
    <dbReference type="WBParaSite" id="DME_0001049001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001049001-mRNA-1"/>
        <property type="gene ID" value="DME_0001049001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720771" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001049001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11733" checksum="2E2E0D6AF6F64275" modified="2015-12-09" version="1">MFLLLFALTTLCGIVNEKAENIKICAIPVSVAQNPPNFLMRPSVPVENCQDRDAAAFSLINTTLSPPAATCRDERLNCAAIRTAHSCSDMFRTTIMQQCTRTCGYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US41</accession>
    <name>A0A0N4US41_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4267</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000533">
        <property type="protein sequence ID" value="VDN54294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US41"/>
    <dbReference type="WBParaSite" id="DME_0001087301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001087301-mRNA-1"/>
        <property type="gene ID" value="DME_0001087301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001087301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7583" checksum="A204030BBAE0F847" modified="2015-12-09" version="1">MSMNDELLTITCLKPSDFNCVMKYLMENFITEEPLCVAVDFTEEDAWNMTSGIDLCTIKLMITSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US82</accession>
    <name>A0A0N4US82_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4305</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000662">
        <property type="protein sequence ID" value="VDN54332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US82"/>
    <dbReference type="WBParaSite" id="DME_0001091401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001091401-mRNA-1"/>
        <property type="gene ID" value="DME_0001091401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868365at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001091401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7791" checksum="B1F9D6A1F7154967" modified="2015-12-09" version="1">MLARQMCPWMCATCCMTKEYNCENATSISPLTSVCRDERLNCAAVRAANSCGGVFRTTMMQQCAKTCGYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USB8</accession>
    <name>A0A0N4USB8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000877">
        <property type="protein sequence ID" value="VDN54372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USB8"/>
    <dbReference type="STRING" id="318479.A0A0N4USB8"/>
    <dbReference type="WBParaSite" id="DME_0001095001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001095001-mRNA-1"/>
        <property type="gene ID" value="DME_0001095001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001095001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21739" checksum="839FF736BB43146C" modified="2015-12-09" version="1">MMNVIDSLANGIAAIVIDKEIGNIFAESMNCNATVLQTSAHLYDGVLDNCIQTQIGEVSLSASFSSNQSKKENIAQEICFENNISQNLLNVAEEKIIGDRCATVVNRNKLKNDRKLLTNLVDSISGSFCEELMENVADELVKEIGNSVLKQEIENVQKQIAARLDKQRLKNFVNQWKKYVAKRKEQRDAEQAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2L2</accession>
    <name>A0A158Q2L2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4726</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2L2"/>
    <dbReference type="STRING" id="318479.A0A158Q2L2"/>
    <dbReference type="WBParaSite" id="DME_0000036601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000036601-mRNA-1"/>
        <property type="gene ID" value="DME_0000036601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000036601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19985" checksum="2BD8E64BB3F2FA7B" modified="2016-06-08" version="1">MAINELQTELAERRKEWIEGLQNETHSIPSIHSEQLNLVKLCCLQSNAETRLEALGFRVGYILVEKVTKDIPRLLTELDKVKFICKEFWTAAFGKQVDNLRTNHQGVYVVQDNKFFTVANFAEGKQYLKESSIFLALPCGIIRGALSNLGIESLVTTSVEALPLVKFHVQLQKSPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2R9</accession>
    <name>A0A158Q2R9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Magnesium transporter protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5061</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2R9"/>
    <dbReference type="STRING" id="318479.A0A158Q2R9"/>
    <dbReference type="WBParaSite" id="DME_0000070101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000070101-mRNA-1"/>
        <property type="gene ID" value="DME_0000070101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044450" evidence="10">
        <location>
            <begin position="28"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000070101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38461" checksum="46358076A2B02DD0" modified="2016-06-08" version="1">MWISGSSAMITPIKISFIFSFIGVIHCDKGLSLEEKVKSLQEWLYKKPIINMNMDRWNTFVRSSPRNYSMVVMFTALSIGCAVCKPAFEEFHIVANSYRYAYPELKALYFAVVDYEDAPQIFSQLKLMTVPAILHFPAKGAKKKIDEMDFQRQGLGADSMARFIKDRTDIQVVLFLYIIRILQPPNYAAPAVVLLLAMLVLGLLYMRRNNLEFLYNRTSWAFVSLCIVFAFMSGQMWNHIRGPPFVMTNPSTRETSFVHRSTQYQLVAETYLVALLYGAISAGFILLNDAADGKGDSGRRRIMVYIGLGLVVFFFSLLLSIFRSKYQGYPYSFLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q335</accession>
    <name>A0A158Q335_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KH_dom_type_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5891</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q335"/>
    <dbReference type="STRING" id="318479.A0A158Q335"/>
    <dbReference type="WBParaSite" id="DME_0000153101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000153101-mRNA-1"/>
        <property type="gene ID" value="DME_0000153101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64291at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000153101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11164" checksum="CF71F43B85E9DCE2" modified="2016-06-08" version="1">MHICRKALQILSEHEKAMKNLGPPLRVGNIDLDDRERNYVGSSKSELRIPISGQLDGGFIEVRAQKQLPADDFITSQVELELNKNNMKIIIYDDGDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3C9</accession>
    <name>A0A158Q3C9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6524</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3C9"/>
    <dbReference type="STRING" id="318479.A0A158Q3C9"/>
    <dbReference type="WBParaSite" id="DME_0000216401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000216401-mRNA-1"/>
        <property type="gene ID" value="DME_0000216401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5980806at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF60">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000216401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="732" mass="82756" checksum="851B84311B53E046" modified="2016-06-08" version="1">MKSCGEMQYSLSQARSTAKHGDPMQAAMVYLAVFRHMKEMDRCCHFDEYCEILNDLMLKNEDSEKLITILTLSRELFPNHPLILNISAKFLFSLNCYVDALQLAHHAIKESEGRNRIEALVNFENIKSNIMDQWHWAMLNDEKRNSVYAEAMKLAIKDDSRVLDIGGGTGFLSMIAYKNSSIVYCCEMDVNLCDLAEKITSSTSIRIIRKHSTTMQLFDLESEKVDILVTETMDSGLLGEGIIISILDAHYRFLSENSIATMYACLIDSQSIVVEHRASINECSFVSRYVQCAESSQLAESDPYWCCYVNELKNGFTILSNCEPLTSIDFNDIGLLEEFYHGTENEILLSCSQNGSANAIMACCELFPGVPKLCTDPDSKSCWQQAIYVLPEPLIVQSGQIVKIKCQIYKDRIICTLADKEISDKVCNLVSSESTSHLRTCYSNNEIQTSSKCENGLSNLYIEKSPTSIRCINNLDFLFLNDASIIPIFTCALGMDDIALSKIIVDITEIPNISLAILSMYPLCRLKCYYQHEEFLTILKTSQNFNRINFISHEDFPCLADIVFCWPITSSGTLFVDSLNHIVDLKLLNPDLIVIPTRIYIRAQLACCPNIRKRAKPNLHAYQNIDLNVIDNLAITHYFDVEVLSMDSNILPNFIYQLEVPSSVLTTFEGQADGILYWFEVESGASLYNSKSEETLARCTVYLFDKCINVTSGQKVEFKTSLFHGNLVMEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4B9</accession>
    <name>A0A158Q4B9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8395</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4B9"/>
    <dbReference type="STRING" id="318479.A0A158Q4B9"/>
    <dbReference type="WBParaSite" id="DME_0000451201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000451201-mRNA-1"/>
        <property type="gene ID" value="DME_0000451201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF452">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="177"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000451201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="39772" checksum="33B56528FCAD8839" modified="2016-06-08" version="1">MSWYSKIYIFERKYRKKHPVTGFLLKMAMNAPLIMNFIIMAYSYYVYIWLICLTCLTSSIQITIYLIIFHAILFMMFWSLIRSLITSTARVPNDYFVMIFHFERLFTHRNMKSNPIQFQIEFHVDEEVDRKLKEITPMKDGKYQPDESSVDQIREQKKILEDFAKSRKLMLFEVDKYNRLRYCYICRLIKPDRSHHCSSCGFCVLKFDHHCPWINKCISNSNYKYFLLYLFYGCCLIIWIFLSSSECLIRYFISEIAISLLEITMIILLMLICIVFGFYPFGELMIYHISGNANADYNIGIYENFYAALGWGFWGIPINTSVSNGLKFPLRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4H5</accession>
    <name>A0A158Q4H5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8738</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4H5"/>
    <dbReference type="STRING" id="318479.A0A158Q4H5"/>
    <dbReference type="WBParaSite" id="DME_0000485501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000485501-mRNA-1"/>
        <property type="gene ID" value="DME_0000485501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02992">
        <property type="entry name" value="PDI_a_QSOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000005">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF20">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250256" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="411"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000485501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="65488" checksum="F17E7C2A7764F9E7" modified="2016-06-08" version="1">MNSFEIFIFFVILLAKSNEAFKSNFTYHPMGYNPLLYTPGQDPIIHLDQYTFNDTIFQQNHAFVVEFYADWCGHCRAFAPFFRSFAYNIQQWKDVVYVAAINCADEFNQMVCKENEVHGYPMIKYFLRNARSANDAVVLRASHSLAELRGQVAHTILNEYSNYQYPDWPNFVPLVHLTEEMWKYVKPSIIYLAIIFEKFDAVGAQFLLDLNFLRDKVTARRASSNSVPPNLQIGNFPSVVLFQRNQSRPIFISMYGERGLEEGGNANHIQLLLIDASRNHYIPLKLCRALYYVSETDMLKAMRMAIYDEVIKIGDKIQGDDFIALYNFIDLLATHFPVTTFATKLGHNYKSVLKKSSEAQQIFKHLRDELSIRSKEQKIAVNDWIHYFLSFESLYGNPFPVNASWQHCKGSSPEFRGYTCGLWTTFHAITVHAYMNTIAQPMDPLKPLLSIKGWVSSYFGCLHCRRHFIHMTTNLFPMNSQRVRRSKDMVFYLWRAHNIVNRRLHGDSTEDPQFEKRQFPPSFICPLCYSGGQFSRKRVRNFLLKYYGTIVPHRSYISLVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q571</accession>
    <name>A0A158Q571_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9686</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q571"/>
    <dbReference type="STRING" id="318479.A0A158Q571"/>
    <dbReference type="WBParaSite" id="DME_0000666001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000666001-mRNA-1"/>
        <property type="gene ID" value="DME_0000666001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000666001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="646" mass="75107" checksum="62D95195E1D5FB24" modified="2016-06-08" version="1">MLHRQHFETDVECRGYSNFAVPFMQNKKPVKLCDLHFNENNRRFEWEKRAEFFMSKYREMKTKESLIEFSKGIFAQSAWVIRPSYCEVMSDHGKDLGKGGAKRHHKVLHDNIQSITKRALRRLNQKYTYIMVYISVWKQGTEPIPSGELPFSFNIIVSNRRGSIGLSSVYQVVCWDRPNFDSLYCSMCSVWITAFEMLLHLMSDTHRLNYFFRNYKNYHKMAVSEIDETVRSRLLEEIAEQVWKLEGSGEVRYRLRCFIDYETVLRIWPNETEVQVNMEENNVRANMSQENDRYCTVPSEMHVRRAGLSKEAGYMFRQMRWDGLDSFNQSKKKNEKYSGSDVMVYFDPHPETCGNALHYGDNKNLKRIRRRSSRSPCSPKIHYINSFSPRERSVHNLFSKIKQSGMETEWNDATAAFLAKIGVAGGGIISSNKNELLTRNEMRRMAGSREIDVYLGCSESTCNQRVNELLLSGLPKSSHLEAPPGVDSDNFSYQRKSNQRTHLEKPIDQAEHSHQQQDPNYDLRKLLGVLVTLQQERERFGNINESSISNLYREMGITEGTANNSNDLLLRLCQMLGSDTVEQNNGSASSINFEQFGYMRPVVTHSHESMEEMEKSSEISEAIVIAMFCHSVSWELLIILEFFNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5G4</accession>
    <name>A0A158Q5G4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5G4"/>
    <dbReference type="STRING" id="318479.A0A158Q5G4"/>
    <dbReference type="WBParaSite" id="DME_0000729701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000729701-mRNA-1"/>
        <property type="gene ID" value="DME_0000729701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8171816at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000729701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51792" checksum="34314B93C8128999" modified="2016-06-08" version="1">MGLHMADDLFSVGNICLVGWSKTVDGGGGPLCIPLIYRSSDFTQTLIKSGSVQSYDLAYMNASTGNDLINGTRNGRMLFSNLAYNNDAFNGIRVIPDEFCADFGALDNEIALVSNGMKGFELSPDLNARIESDDYCGIIQQIKVGFEVIMKAPDEFSIWSQNIVDRMRDLSFNEEALLKVVEMSLQMATAIDSTQYTFGQLFKYIQEGLPQLHFGEKFLVPVLLEFTKSQRRLLVDNQKRNLLHLFAEIFASFLTNAGEKFPCLVKSFGEQLYEFTNNDCLNEKKITDESLIAVIGALQVSGKYLDSDPQGNEIMNVILTRLNAFANAHPGISSHVKDKIRNLNVMRNNDWYSTDEKRLVSDITIADSDFSDIIGPDGKPLTLEELEFLQSQIDKVESQRSTAVDPEDLDNLDITRDYEDFIEMVEEEREMKRQLESNVQTIETDFPKLDLNDKGVDDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5L7</accession>
    <name>A0A158Q5L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1940</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5L7"/>
    <dbReference type="STRING" id="318479.A0A158Q5L7"/>
    <dbReference type="WBParaSite" id="DME_0000772201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000772201-mRNA-1"/>
        <property type="gene ID" value="DME_0000772201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="168"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000772201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119319" checksum="B751B57962A3848F" modified="2016-06-08" version="1">MQLFVIPNYDELIPQTSYSKDGHLERLFININDKNLELPFQPSASMLISPHWAKIFRHKNGSGHLSIGGQIKQCHYQHKSNHTYAAKGVIIRPDGLFLIHPYPERYAYRSKSITDGHGMHVIFKRHVNQNDFCGLESTISANDLDSDENAINEDVFVIGQRFTAISDLVVELAIFVDELLWRHFNSKYNREAYSKLQDYALTMLNNIQIMYRQPTAVPPLTFHVVRFDVLSSQPNALASTLHDNGHAQRYLDRFCRYQRSLGGRDWDHAILLTGYDIHRGSGSRAISGIARLDGMCDPWNTCTLAEGLDFTSAFIGTHEIGHSLGMRHDEPYCPSKHIMSSSLGPGKVTWSTCSLRDYHAFLQRLDDRGKNCMRVSNLPQKLTMRNDIRPGQLYTADHQCRLMHGENYRQISPRQDHYDGICYMMWCGTTSFGRIVSSHPALEGTFCGASKWCELGRCVPWTGSKFAPQTASQSPVRINGEWSSWSATACDSCSCHDISNSIGLTISTRTCSNPSPLNGGRECIGASIRGIVCNRKCPNTRVTVDEYITEKCTEHKKLRNDDELTGKGSQLNRYPQRACKVFCDVSRKYGSQRNYRFFGNNLPDGSPCGINKYCLDGECIPLSCDDTSLITRDLLCPTEGCPLSNEYTSSSNKWSVWSPWSFCSETCGTGYRMRTRTCNGYGCTGSATDRIACNLSPCPTTKTPYTNAWSEWTTWNQCSVSCGYGSQARYRRCVSATSTSNACAGKTMEIRECKMEVCFTGLVGLWGSWGEWSQCSRTCGPGIQIRNRYCTKEPCDGSGQSRKSCNLRSCGGISQQWSAWKEWSQCSQLCGRGLRTRMRKCYGSDCIGNSIEQQFCNEQPCLAQSGRWSGWSPWGICSVTCGAGIKRRTRHCIYGNCAGTYRDSSTCDQGACSDSTATWGGKQDLENLSQITQAVSSLVTTQPDYTIKSTVDGANTLGSTTSYDLKLTKSFQISLTTMKLVDSSNGSVNFLSVDISTTPKTFGLLPNRKKNYRRFWLFRWGYWSTCSESCGKGIRKRVRKCYSNAATSTACAGNEYEREICNLGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q620</accession>
    <name>A0A158Q620_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">guanylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10503</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q620"/>
    <dbReference type="STRING" id="318479.A0A158Q620"/>
    <dbReference type="WBParaSite" id="DME_0000886501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000886501-mRNA-1"/>
        <property type="gene ID" value="DME_0000886501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF16">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="383"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000886501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67772" checksum="E790C078DA88274F" modified="2016-06-08" version="1">MRLEFRFQFGFIHECMRQMIIRNYGAKAWTSILRRAGFSITDENIVNLYYSDSSTFAIVDAILWEMYGKFHIEYIIEIGWEELVQTISPDLRGLLNNIDSLHYFISRIIYKSEWKCPSFHCEQNKDGSLTLDYRTYRNGIYPTVKDTSEDQLVGRSAHLSQYDFVVIFPYHLLFDKDCKLLQVGKELYNHICRDLLEIGTPLTQIFQIVVPRIIFDFENICIFRDSIFVLEIKDAKFSLLLMTIILELINFSSEHQRSFVSFGRNLGLKGQMIPLDDNNQMLFLCSPLITTIPDLLEFGMRLTAMPLHDANRDLILLNQQRISDEEMNKQLQENNAQLEGLARDLEAEKGKTEELLKEMLPASVATQLLHGKSVDACEFNEATVMFSDVPNFNNIVPNCEPKEIVALLNDLFTKFDRLVVRHGAYKVETVGDSYMTVGGVPEIRLDHCEIICDLALGMLWESHSVTDPIKNAPLQIRIGIHSGTVVAGVIGNKMPRYCLFGDTVNTASRMESHSVPGRIHCTREAVELRNGQHFQFIMRGKIQVKGKGLMNTYFLKSNNKKTIWEIIGREKGKIVFLVCYQFRPNQIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6B0</accession>
    <name>A0A158Q6B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3255</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000117">
        <property type="protein sequence ID" value="VDN53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6B0"/>
    <dbReference type="STRING" id="318479.A0A158Q6B0"/>
    <dbReference type="WBParaSite" id="DME_0000958801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000958801-mRNA-1"/>
        <property type="gene ID" value="DME_0000958801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000958801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27735" checksum="5452CE0A8B2CBF22" modified="2016-06-08" version="1">MEKTLEKSSCIEKKETNVELLTPAEFEQISVSEESDVEKSFRLPRRVHFSQLREIRHMPLSIADEAKQARLPYSGAQYLCEYLPRSFKYIFLLSIMWIISSVFLVTEYSISTYGALLALLSSFLYALYLVMFSYFQYQGLDIDINFLLGFVGVITLFLYAPVMLSLDYFKIEPLFPLPNFYQFSIIILNGVNNLFSDFLWLKGTIWTSSLASSISLSMCIPLSFIADTVSFLIFKNWSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P3M4</accession>
    <name>A0A3P7P3M4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P3M4"/>
    <dbReference type="STRING" id="318479.A0A3P7P3M4"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="422"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="5">
        <location>
            <begin position="698"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="89073" checksum="C476D9EF347548A4" modified="2019-02-13" version="1">MQPIFSSGIPTGDAFAVIIGGGIAGTSVAYHLTKRNFRDIIVLEKDKLGSGTTFHSPGLVSAAHPAHRFKPILARSVDLYSRLEEETGEKVEFSRSGTLRLATNSTRMNEFRRYVARDYFQKGDVCKTSLIDANEVQKLTNIVDTSKVLGALYTTGDGYVNTEALTRALAKGAEAGGAKIIENCSSFTLTEQSNGDWIVRFENGSEIRTINIVNAAGLWAVEVAKLTNYDLPLTFVEHQFVGNLEYLPAIVDHDSTFYIRKDGDHLFFGGFEPRASDVVIREDWHEATLEPCFERLSAAYGRACELIPCLNGSPVDARACGVTITADGYPLVGPTNERQNYWLQVGYFDGISSCGGMGKYLADWIVDREPPSELFDTEASRFNRWATRKFIKEKSQETYSMFYNWSYVNRLAGRPSERVSGIYARLAKQGGIFTFRNGWEVAETFPVDDESPASAVIREYQMVTNKCGITDLSWKSKIEVRGADSVDFLYHLLTNQVPKLGTISSGLMLTTNGNILAPLKVFHHDQFRTEFILLTDPERESRDIDWMKRVAAERRANVDISAVGEYLASVALVGPCSREVLQNLTITDVSDKSFGERSTRLIRIQNVPVLAARTSTTMGQLSYEFFHNKAGKQFGIVNFGQATHNMLRIEHGFKLWGRELTLDTNPFECGLEHLVDITKKDFIGRNALLKIIDTKWKRRLVLIACDPLKDLKDWACVPKGMEVIRRKGEEERIGQITSGTYSVRLNCPLAFAWINSDVTLNDEVYFERLHSYLFIILVLYLCKTAFIFHFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PIG3</accession>
    <name>A0A3P7PIG3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000216">
        <property type="protein sequence ID" value="VDN53940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PIG3"/>
    <dbReference type="STRING" id="318479.A0A3P7PIG3"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding oxidoreductase/transferase type 4 C-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="226" mass="25045" checksum="319B316A0C06FD89" modified="2019-02-13" version="1">MTEKPTLFLEFHGHTDDDVKQQTKLVGEIISNFKGKGFLWSNSAKENARLWTARHNAYYAIVSEKKGCRINFSPTNGFSTDVCVSISRLAEIITETKKDIDTSGLVGAIVGHVGDGNFHCIFSVNENDRSEMKKVWELSDRLIMRALSIGGTCTGEHGIGIGKKEYLKKEIGLIGLKTMSVIKQALDPNGIMNPGKLPPQTISISSIVIQFSTNLPRFPFFHRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNI9</accession>
    <name>A0A3P7PNI9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNI9"/>
    <dbReference type="STRING" id="318479.A0A3P7PNI9"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF10">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56069" checksum="7063606260AC46F0" modified="2019-02-13" version="1">MQEQAYILPQNTSNWRHTEGFLKAIIEILLKYIKDENDRSEKVLDFHHPSDMQTLIDLTIPDDPFDLQHLIEDCKRVLRLGVRTGHPRFFNQISCGLDLVSMAGEWLTATHFRFTYEIAPVYILMEKEVISRMVSIIGWEHGDAIFAPGGAISNLYAMNAARHYRFPRIKPLGQSDQPTLCVFTSEDSHYSIKSAAAVMGIGADNCFNIQTDQAGRMIPEALEEKIIQCKQEGLMPFFVCATAGTTVYGAWDPLHSIADICQRHKLWFHVDAAWGGGLLLSPEHRHRLSGIERAKSVTWNPHKLMGALLQCSACFIKQDGLLFQTNQMSADYLFQQDKPYDVSYDTGDKAMQCGRHNDIFKLWLMWRSKGMEGYRTQVNRLMDLAAYFTAQLKATEGFELVIDPPEFLNICFWYIPPSLRTLNPVEKKARLEKIAPKIKAKMMERGTTMVGYQPDKQLPNFFRMIISNQAITNEDLDFLIKEIIEISKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PRM4</accession>
    <name>A0A3P7PRM4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PRM4"/>
    <dbReference type="STRING" id="318479.A0A3P7PRM4"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="203" mass="23229" checksum="5FBD27EEE2DCB16B" modified="2019-02-13" version="1">MCQVLSAVKTELVDALKDEINAEKQLETENFGKDYVPTIPGFEITTNDAEVRLKKTHGNEKILVIFNVNHSVDINDEFHETENPQEVVPVALPPLTIEITKGDERLCFHLELVEPGVDNGEFDFRVEEFYIAPVSSDEEVPASVYASSGRYIDPHLHDLLFVRFLEERGFNTQFCQQLVKFATHYEHSRYVSLLDKIKNFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUB2</accession>
    <name>A0A3P7PUB2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUB2"/>
    <dbReference type="STRING" id="318479.A0A3P7PUB2"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000009">
        <property type="entry name" value="TBC1 domain family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="263" mass="30559" checksum="E23F27FC9E17F8ED" modified="2019-02-13" version="1">MKFIASPTKKAEKEYANVVNDENVEYHWQVVERILFIYSKLNPGVKYVQGMNEIIGPIYYVLASDNDDEWARYAEADAYYCFQLLMSEIKDNFIKTLDNSYCGIESLMSQFHERLQICDEALYKHITDLAIKPQFYAFRWLSLLLSQEFPLPDVITIWDSLFSATNRFNLLCNICLAMLEKERDELLSADFSTCLRLLQNYREIDVGQLISFAHELEDGLYARCSSSSIDNRNSKNQVEKVFSAQKSKLIASLSNFIKTFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q407</accession>
    <name>A0A3P7Q407_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDNF/GAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q407"/>
    <dbReference type="OrthoDB" id="5776214at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GDNF/GAS1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="176" mass="20119" checksum="CE1EBE889479716E" modified="2019-02-13" version="1">MEISYLAVNRITNTCQPQCRNAVLNLYQNRLGRTLLRTDVSCLPARHELELCNLLPNKMPTYCSLTKLICEADLQCNAKWGIFMSECEAEAENGRCNKRCSDRLNDTIETFHGTALSSCTCNENDDELCKILRKTVQLCLKVFLTICDENGTIKKMPSMQFAFVFIQFVVLFTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SQ52</accession>
    <name>A0A3P7SQ52_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SQ52"/>
    <dbReference type="STRING" id="318479.A0A3P7SQ52"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="330" mass="39200" checksum="57272416B437E45F" modified="2019-02-13" version="1">MEMTNSTSKTASVNYFCDICLKELRKYRCPKCSYRTCSLICSKLHKEKLNQQSSDLCYTPVQRYLLNNARRRRIWLTITANKESRHEQFSDTIFWSILLIFRREINKDGEKGVVDYNFSVNNIPESISLKTLIRQFIKPKKIGPVVNKDELDEEKLLPFQDAGMDRLMIYMPVPISILDNLRNRFIIDHPTFIITLDDQFNDYVMLSEQESQEMREKQRQQERNNDFNRGRFGHVSSVFCIASKIFCLIISFSYFFIYPLIPLFFQFFGGRRGFRNGCKAQGNKGKAISHESGRKRFHEDENLHQNRNSWKRNRRIDRRTESGKYYGHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0E6</accession>
    <name>A0A0N4U0E6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4382</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0E6"/>
    <dbReference type="WBParaSite" id="DME_0000002201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000002201-mRNA-1"/>
        <property type="gene ID" value="DME_0000002201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000002201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14029" checksum="E9AE9EEF88F79FF4" modified="2015-12-09" version="1">MESINVDLKEKRMNANEESGKSRQSSLDECVERAADILKDLEDAKQSGKTKYPFKFKKCVLKAGDIGRCIYMMEKYATDYKAMSLDPRNAFMDSESTLARKIRIFKETNEYQLYLMKKGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1B5</accession>
    <name>A0A0N4U1B5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4746</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1B5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1B5"/>
    <dbReference type="WBParaSite" id="DME_0000038601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000038601-mRNA-1"/>
        <property type="gene ID" value="DME_0000038601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864015at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000038601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17634" checksum="95159103A0EFD10E" modified="2015-12-09" version="1">MNADIEEYKLMAASRSGYLRLVQQARKATSDLDVIIRLCRNLNDNKVTIKMEMIEVESQKLKPLIKLPKIQLMKFDGSVRSWVAFKDNFLSTIGNRSLDPVDKLRYLISCLEEEAKKLVEGFPMDDGSYRNVWEILESRYGDKSIIVEDRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1L8</accession>
    <name>A0A0N4U1L8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4869</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1L8"/>
    <dbReference type="STRING" id="318479.A0A0N4U1L8"/>
    <dbReference type="WBParaSite" id="DME_0000050901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000050901-mRNA-1"/>
        <property type="gene ID" value="DME_0000050901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000050901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26956" checksum="D029E1078844E076" modified="2015-12-09" version="1">MEITDKPLKNHGLCSSFSNISIHPLVIMNISEHWTRIRAQNPALASAGAYNFEVVGALLGVESGRHLEVINSFELNFDTLTAVFDEEYFKNREGQYKEVFPNLDFLGWYSTGNLAISENDTVIYKCLAKFSLTQVVIKLDPCQCFHKLPLVVLEPVPVDGSVQNDLEWKELPWDLASEEAERIGIEHIAQISTSSSTSKSFLNKQLYGQLGAINMLLSRLQIIDNYLTVYFHIFKHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1M4</accession>
    <name>A0A0N4U1M4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RILP-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4876</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1M4"/>
    <dbReference type="STRING" id="318479.A0A0N4U1M4"/>
    <dbReference type="WBParaSite" id="DME_0000051601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000051601-mRNA-1"/>
        <property type="gene ID" value="DME_0000051601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069524at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF4">
        <property type="entry name" value="RILP-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="7">
        <location>
            <begin position="255"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000051601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44516" checksum="947D94CE529DB850" modified="2015-12-09" version="1">MSNRSPSQSPSRHITVVDVYDLAASIGKDFERIIDLFGSDSVRQIMPKVISALETLEALANNNEKENEEIISLKKAVERLENDKYLKQQDRLKFEMELEAIEENYRKEIDDLWTMVKNLQLENRHLSELSSHANSPTLPGALRDEDLNVMLELRELSNKQKEQIKELQKDIDTYSCEVENLHNNIEKLIRQNEELLRKNASLQKQGRMLVEEKSDIIKRLQLTEESNIKLTKLFKDATRQCKDLQQYQMEDGENAPKFTLAELREVLQEKNLLKGKVMELEEELEQLRPKSSSSSSSETNKDLLFETRSSNSDECTVYGPINKEPEEKLRPWKYERKDSGVRKFFRFFFKEGFKDSPMHAPSSPVPPMRTMSSLSNINVSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1Y2</accession>
    <name>A0A0N4U1Y2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5008</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1Y2"/>
    <dbReference type="STRING" id="318479.A0A0N4U1Y2"/>
    <dbReference type="WBParaSite" id="DME_0000064801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000064801-mRNA-1"/>
        <property type="gene ID" value="DME_0000064801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000064801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32715" checksum="62893D25D9E4A8A8" modified="2015-12-09" version="1">MAVNYANALSPYDNKGNLGLPELFDDDATLERKILELSDLIKQSRCCVFHTGAGISTSAGIPDFRGPKGVWTLEAKNEKPESVEFTNARPTFTHYAINALERRNIIKFLVTQNVDGLHVRSGFPLNRLAEIHGNVFLEICNKCGRRYYRKEPVGSIGRKPTGRDCEGTLKGRSCRGRLHDMCLDWEDALPEDDFSMAIKFCKKADLSVCLGTTLQIAPAGDLPLLAKKNGKMATINLQKTKHYKRTDLIINSRCDDVMRRLMEILQIEVVEDYKEDNVIPFSIYPLENFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Z5</accession>
    <name>A0A0N4U2Z5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5437</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Z5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Z5"/>
    <dbReference type="WBParaSite" id="DME_0000107701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000107701-mRNA-1"/>
        <property type="gene ID" value="DME_0000107701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000107701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10843" checksum="E937E15D72C542DE" modified="2015-12-09" version="1">MGSIRILPQWIRIWLNISTVLCIVDVAYTMLRPMTLRTGSLGHIFELWNIYSDVDLRYANANDIVTMATGRVMIIEIFMNIIALIMITTKRVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U374</accession>
    <name>A0A0N4U374_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium homeostasis endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5528</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U374"/>
    <dbReference type="STRING" id="318479.A0A0N4U374"/>
    <dbReference type="WBParaSite" id="DME_0000116801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000116801-mRNA-1"/>
        <property type="gene ID" value="DME_0000116801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="165"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="714"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000116801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="784" mass="89425" checksum="458ACF3D6F592272" modified="2016-06-08" version="2">MERTLAPPQGSNVGSNFNNINNNPPQVPPDDDTRNIIDRLAEFVAKNGSEFEERTRKKQYGNPRFAFLFGGEFSDYYRFRVMQEVQQLNQGTVPPSQAIQPSASSVHQFDASAVLAQINTLNQQIADSEANLRAQFESIEVRREAQLAAAIEESETKKILSVCEQVSLNVEPLSKLLDQLSGHCSKDVISNSKKWIFEHCTTDRLREAILMYLLYRVKETRATEQFKLHILYLINDWAHHCQRKKLDAIRQMLSRYVPQLYAFTAQGVKDAALNEKLEKLIGVWEGHKYFDDGCYKQLRNPLLLYQNWKNAQQAEYSKKSAEIHAQLLAAYRGYEQQHLEFSMHCRNQIALLQQQIDEQMNKQVGASSCSEVILKPPMNRRERRSRFDQKVAGPPPELPPESDYGRFFAAPPSGSSKCPSPRDIYHARPDECDEPPFALYNEREFPNENRNEPGPKDAMFNLRPPFPGGPTMMRPPCGPPPIFDESALIPSCPYYNLPAGMMMPLIEMGDVLYKPVIVSKLRLPPPIPPSERLLRAIEAFYAPPSFENPRDADGWERLGLFEYYMKKNDIKKRLEESLKLEGKTIEDAIENIYIEDNDEEKNDEKIRRSTSRRSSTSSRSKSSSSSSSSRSRRRRRRKRSHSISNSGSSSSSSSRGRRRSRRSKSPSPRRRRRSSSRSASPESRPAFGGSSRRDSRSPTPKFLLPSGPPPRLNAANKGAQLLAKMGWQGGGLGSEHQGIKEPISGGEVRDHVDQYRGVGSKPDMYEEYRKQMSGYHRNRNRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3F3</accession>
    <name>A0A0N4U3F3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5617</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3F3"/>
    <dbReference type="WBParaSite" id="DME_0000125701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000125701-mRNA-1"/>
        <property type="gene ID" value="DME_0000125701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000125701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7868" checksum="9A8684F65897552F" modified="2015-12-09" version="1">MKIFRIRSFEEYGKGEVVQLCKWDEVNGGDGDDDDDGDVGNRKKRGLIHQHSEAIVERESRERERIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U447</accession>
    <name>A0A0N4U447_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5901</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U447"/>
    <dbReference type="STRING" id="318479.A0A0N4U447"/>
    <dbReference type="WBParaSite" id="DME_0000154101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000154101-mRNA-1"/>
        <property type="gene ID" value="DME_0000154101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6537982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000154101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22049" checksum="3C128BE9CF365690" modified="2015-12-09" version="1">MCIISSKELPIISFSSMENLILWESWIDQTCCRGSLFYLQLLAAPEKSRANLSLYREVRLHMHDGRFALVEGRPQRIIGFWRIKDVIRISFISNVLHFFAHDPSGVDDGMYSLACGKIEEIEKHFSMCKKAGVLLSYLRHKSGNDCWLHAYAESVSPVSNRSYTFHYPVLQFNDGFPEAVPPSQKQVAFFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4A6</accession>
    <name>A0A0N4U4A6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IlGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5963</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4A6"/>
    <dbReference type="WBParaSite" id="DME_0000160301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000160301-mRNA-1"/>
        <property type="gene ID" value="DME_0000160301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834437at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041081754" evidence="3">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000160301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14641" checksum="007F602FEFC29A48" modified="2015-12-09" version="1">MRKFSYTIMFITVYFATLLLKNAETFHHTSANQGLIKMCPPGGPAFATAWQLSCGMRKKRSTTSSSPSCTVMYETYKKTILDLPKRVKRKAGYRPLSLTEMMQYCCHFGCTFRDLFPYCDPFGRWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U545</accession>
    <name>A0A0N4U545_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6309</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U545"/>
    <dbReference type="WBParaSite" id="DME_0000194901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000194901-mRNA-1"/>
        <property type="gene ID" value="DME_0000194901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000194901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18666" checksum="BE47EF47F5B2F179" modified="2015-12-09" version="1">MILRAPCRNARILWVTQIQKAIDSFEIDTSRKSGESSIDAAGLGRLLIELSFVGNIETSLTCDKQIVCRFELGKHSATGEANLKNEECLFTTQLPIISMDSIFHVSIFIPCIYSPDICAGTGEIKLEDLITATSSHRGPISRQFYLDANHSNTANRPFVIIKFVVQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U550</accession>
    <name>A0A0N4U550_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6314</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U550"/>
    <dbReference type="STRING" id="318479.A0A0N4U550"/>
    <dbReference type="WBParaSite" id="DME_0000195401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000195401-mRNA-1"/>
        <property type="gene ID" value="DME_0000195401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF56">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000195401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21346" checksum="7304488EE4E0F8FC" modified="2015-12-09" version="1">WNIYFKIQILADTLFTRKELRAIYRAFKETSPFSRDTFRVAFAMLFPYGDIEHYADLVFETFEPNDHGFIDFHASFYIIRHNAYVKKNMKFIKIFSALARGPLNEKLDWIYKLYDPVDTGKIDWDRIFYVVTAINDLMGKKFDKSKKGWITKEEFMEICSTDEDIFKSISSLCNISECSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5Z3</accession>
    <name>A0A0N4U5Z3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="3">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EIF6</name>
        <name evidence="4" type="ORF">DME_LOCUS6665</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <text evidence="3">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5Z3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5Z3"/>
    <dbReference type="WBParaSite" id="DME_0000230501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000230501-mRNA-1"/>
        <property type="gene ID" value="DME_0000230501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000230501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="29100" checksum="82719D09A8EB048E" modified="2015-12-09" version="1">MAIRCQFEASDEVGAFCKLTNSYCLIGIGASANFYSLVEAELADTIPVIHCSIAGTRIVGRITVGNRHGLLVPYATTDQELQHIRNSLPDSVKIKRIDEKLSALGNVIACNDYVAMVHPEISKETEKASFLFFKSFLYENFYFISLVVGHFQALKEILNVECFKVGLGPQALVGSYGAITSNGALVAAKTPVEVQREIASLLQVPVVAGTVNRGSELVGAGLCVNDWIAFVGLSTTSTEMSVIESIFKLGDSLPSAITSNLRDTLIESML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U647</accession>
    <name>A0A0N4U647_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6732</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U647"/>
    <dbReference type="STRING" id="318479.A0A0N4U647"/>
    <dbReference type="WBParaSite" id="DME_0000237201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000237201-mRNA-1"/>
        <property type="gene ID" value="DME_0000237201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17399">
        <property type="entry name" value="MFS_MFSD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000237201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="52990" checksum="8409838261FC006A" modified="2016-06-08" version="2">NKSREFFYLCFLRVYGRRWIILAIVALLNNSNTMSWIAFASIANHVDEFYRMNKAANWFSMVYLLCTIPVGIFAMWLGSRFGLQMTIQIAAWANAIGGLIRLSSSFAPVHYRFPVGIFGQAVAACAYPFIMFLPPKVAGTWFAENERTIATTIGIMSNPLGVLLANLISPQIVTNSSHVPIINIITFVPTFFACLLAVIFINRSQPKMPPSFSAAQNQMCFLPGLKSVITNKSYILLLVAIGGGMGMFNCLYTVMQQLLCASGYSNSFSGFCAALMIIGGVMGASLTGIIVDRTKLFEEILKIGMALAVICGLLFLQLTLHPGLSIALSIVSFVFGVFGLAIYPVALELASECTFPVSETTSTGLIVLSGQVQSIIFVALMQMTGQALQEEYMHIQVCTSGVDSVAATPQDSTYSIIVSFTVTVMLIVMFKPIYKRLLVEQGIKATNTTGIQLKEKIVEKKEGENDAKIVFSNDAKALLTDEIDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6I2</accession>
    <name>A0A0N4U6I2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6894</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6I2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6I2"/>
    <dbReference type="WBParaSite" id="DME_0000253401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000253401-mRNA-1"/>
        <property type="gene ID" value="DME_0000253401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976048at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF12">
        <property type="entry name" value="PROTEIN CBG09110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="5">
        <location>
            <begin position="204"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000253401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51138" checksum="435AB4D1AEF176FB" modified="2015-12-09" version="1">MNFSFFILKSFKAVGAIRSAIVAFSSSQAKLTSSLGISSRQDSLKEKNSLNTDKNVQSNANNVNQENSTSSTNQHSGVKLSDLEPSESFLSCLNDTTRYNKYLQVKKELKVFLWMSKIVPKTLTDLNWERLLKRETTFDRIKYILFLAAKQKRRGIKHQIEIEEENENEKRAQIIREGGMAYGSGGYRMQPNPYRHKRVIWLTEAAKMFMSMKIDEKPHIVFDMENFKNLKHRNQFAIADSMNAVIAANFDLNVPFQITFANFYDSDDSPERNWAINEFFAAYSTKFANARMLPDWTSRSVKELYPHFKKGDFVYFSGKAKSIYDGPLRHKVFIICGEHEFGKISLAAARKSKIEAYRLPLDRYVKWEQGHKFMPFVNLIRTLDFVWFNNGDWRSAVRDNISKRYIKPRDPRLESIKTCDSSKLSFVNDVVRVVEEMDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Q1</accession>
    <name>A0A0N4U6Q1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MRH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6977</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Q1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Q1"/>
    <dbReference type="WBParaSite" id="DME_0000261701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000261701-mRNA-1"/>
        <property type="gene ID" value="DME_0000261701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056609">
        <property type="entry name" value="Elapor1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056608">
        <property type="entry name" value="Elapor1/2_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056610">
        <property type="entry name" value="Elapor1/2_TNFR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF15">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23031">
        <property type="entry name" value="GBD_ELAPOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23032">
        <property type="entry name" value="GBD_ELAPOR1-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23091">
        <property type="entry name" value="TNFR_ELAPOR1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039149" evidence="4">
        <location>
            <begin position="22"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="5">
        <location>
            <begin position="639"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000261701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="964" mass="108946" checksum="E8E41C2CB3D1D087" modified="2015-12-09" version="1">MLPILRLFFISYCFFISKSLTRHCSSDDFIFEYTTCDENGQRWRVAVPKNDHLQCEGGAPFPTRGINCSFSCQPGMFLDVDSQKCRHCSPGSYSLGGGIRFEEFSRLPPGFVIENFDTNIDIFSGTTLKNSGCSNETGWITKNTELLYVPSPCIAKLTYSVDLVRPGFVQYSYKLPKDSRGLSLKVIVRNKQCQSYTRKPLKENERDYEGEWQRRRIKLKSGTNVITWMVFNNRDIFSKNDVIAISKIDILGLAFTQQCTLCPAGTYSDRGARQCKSCPAGYFSTKGSRECARCPLTQYSGPRASMCIDRPVCAETDYFPKMEPCNDLGLTRIVYEKVQPNVCRDDVEGSYKLPPPGQSRPCPKCNPGMAMNNNKKCSFCPVDHFSEGNECERCPLQTLPNYGLQYILWHDLPPNMTTKCEYIMEDRPKFCNIGNSWIPAGNSLYSSSTHEKGIVLELFLNISEGFSNPLLSNDAKISLQDPIAHITFEFETSCIDISCIFYFVEDSPKQASFHLIAGFNGTQARRSYSYPIISTRPTRFLFAFMRSWSSSENDAITDRAIIYSINVTNVARGSGGASACLPCPLSNGKCVTCPSGQYISETVTCRKCPKNTILNVSSDHIGIKSCIPCGSNLESNDGIRCSSSGLLEIPRNSSNVTSHFDFTNFIGKTFQATGVKVFAREGSSYYHLFNISLFNEEGAICNEEISANELDGNSPQLNFFYESSSSVDYCPNGIHTVVTTKCEPRLVEESEVLNLMAFFHICLTNYEIYLFIWKLFQLFLSLLRTLSLFSYECLVVWVACFLKVHLPRNCPDGTCDGCLYHMIILTARACPICTESDYTVIRGECINGKQTVHSIPSSNHYYDYLHIFRDSLRDKHIFYNFFRLEYKYMKLVESKNPSKGNELPAAESCGVIGDDEEEEELDRVLFTKGKKKFSRGIRKNRRIFDNQSKNDNLETPFVPLEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7L9</accession>
    <name>A0A0N4U7L9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMRFamide neuropeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7148</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7L9"/>
    <dbReference type="STRING" id="318479.A0A0N4U7L9"/>
    <dbReference type="WBParaSite" id="DME_0000298901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000298901-mRNA-1"/>
        <property type="gene ID" value="DME_0000298901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041080014" evidence="2">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000298901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23836" checksum="0624AA9B28897D07" modified="2015-12-09" version="1">MFTHTLLLVIASFQITVQFSQYEFDRRLRGLNVQPGNIFNSDYENQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRDNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKDLFQYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7M2</accession>
    <name>A0A0N4U7M2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase C9orf114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7151</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7M2"/>
    <dbReference type="STRING" id="318479.A0A0N4U7M2"/>
    <dbReference type="WBParaSite" id="DME_0000299201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000299201-mRNA-1"/>
        <property type="gene ID" value="DME_0000299201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000299201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37658" checksum="861ABF2EF18957CC" modified="2015-12-09" version="1">MKIISRFLLSQYIFILGKFYKLSIALPGSILNNAQTMELRTYLAGQIARAAAIFCVDEIIIFDDTARMTSEFVFWFEIFFTKYTYFSGSWIGSTSIQQGLECNFQLAKILEYLECPQYLRKAAFPLQNALKYCGILNPLDSIHHLRQDDLHMPYREGIVLDKPVKKGRGPFCYVGLKKEVQLDSEINLPPGTRVTVKIADFSSEMKNFRGSLTSPAKIRSEAGLYWGYKVHLALSLNDAVHVKRYDVIIGTSDKGDPIEKFTLPLGEKNDILIVFGGLEGLEAAIDADESIETNDPAQFFDFYLNAVPDQGSRTIRTEEAIPISLTALKMKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U825</accession>
    <name>A0A0N4U825_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U825"/>
    <dbReference type="WBParaSite" id="DME_0000317101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000317101-mRNA-1"/>
        <property type="gene ID" value="DME_0000317101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000317101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22426" checksum="E95272831B117DA3" modified="2015-12-09" version="1">MHDIRMDPMLKFSLALADGAFNRCPAISLLDAYIVQRFLRIMLTNYHRKKGETMKDTKQYLKRWRIKTVNCGQSCHSVMLVLLVAFIFVRRGESGDDGVPLTKCLAPSNVVPVVPRPLPLPTACKDKDPTICTAIFAVRSGAVAPNSVATNPFLVNPNCQNVTVMVAAEALCPSSCAVCCLTPEFNCQNCMFLIVPVYLILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8H2</accession>
    <name>A0A0N4U8H2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8H2"/>
    <dbReference type="WBParaSite" id="DME_0000334401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000334401-mRNA-1"/>
        <property type="gene ID" value="DME_0000334401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000334401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18174" checksum="27C814F99749C48A" modified="2015-12-09" version="1">MNIKKSKQQRSSISPCRTFDSSKQIEATSEEEFKSIFEKVSSSCFCISGDGEGSNHGADGGNRGGGSDDDRGGDGGNLGRDRCDINEELYDKAWKQFDTVSQRCILEVRCFFHHKEFFYKERFCFKFINAVNRERNQRGLRVQFIHQCGRVWHPMKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U984</accession>
    <name>A0A0N4U984_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7638</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U984"/>
    <dbReference type="STRING" id="318479.A0A0N4U984"/>
    <dbReference type="WBParaSite" id="DME_0000363301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000363301-mRNA-1"/>
        <property type="gene ID" value="DME_0000363301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5853746at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="3">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000363301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48483" checksum="455A2885625AA402" modified="2015-12-09" version="1">TLETLDVFWEIWKDEYLNSLRERTQIKHKSPRSAIIRPPSLGEIVLVNEPHIPRGMWKLAKINKLNKSSDGNVRSVQIELPFGKLFNRPVNMLYPLEVEQEDQPKDSATELTNAKDEEPIENEEPIARRTRSLARQQRNPISLRSKSSFTMLCMLVTVLSIMSTRTLATKTCKWSGISFNIAKRKHHTKHELKVGIISKFEIERTNAEIEILADKQKPNPVSYQQNMETIWQEISQEGEELAEQLDDEIGKATLLIQNELSEFAVHWCMIIGGTSVLILLIVLIIVKLNCQLILFPLCPKCSRNSNQKTVAIPMNLLREDLHNKKEFKTTIKNVLSYQPKFLLLASFLPSRECREFSRNYESLFIKIKRSQQCREYREFSRNYESLFIKIKRSFLLCFFLLKRCVGVGFPFFLQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9E9</accession>
    <name>A0A0N4U9E9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cleft lip and palate associated transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7711</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9E9"/>
    <dbReference type="STRING" id="318479.A0A0N4U9E9"/>
    <dbReference type="WBParaSite" id="DME_0000370601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000370601-mRNA-1"/>
        <property type="gene ID" value="DME_0000370601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000370601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="594" mass="69580" checksum="DF51984C2FE2D68A" modified="2015-12-09" version="1">MGNPNINSGGKSNFQPSTNLYNFGQKFDIYVYLSDSIERFNSFDDPSALFWKETGIIYGDWTSGKSGDGSRTKSVTIPTPAPLINNQSLFIHVFVVKEGHSPNPEDRNYFGREVIYNSKRLNRYKKRYYKKTQNLLTGKTEQSEEEQRKADLMNYEILNYWHPNLTISLVYDQTAWQKGSLPSPLDEAIKFLPIGNTYLPIFLFNDYWNLAADFLPINNSVTELNFTLTFAPLSLFKWQLYASQQVSKWSQMVQMFGGDSSVEVDDDDDQDSIKQMLLETNPILLVKILLEFYYYFYYYNRFLIYTITGITIFVSIFHTIFEFLAFKNDIQFWRSRKSLEGLSVRSVLFNVFQSAVVFLYICDNDTSWIIKGSVGIGLLIEIWKIPKCLNINIDRAQKYFGVIPKILFSDKGSYIESDTKKYDELAFKYLSCILFPMLGAYAIYSLIYVEQRSWYSWILSMLYSFLLAVGFIMMTPQLFINYKLKSVAHLPWRMLTYKFINTFIDDLFAFVIKMPTMYRLGCFRDDIVFFIYMYQRWIYRVDPTRVNEYGVSLDDSTSAEEMKKLQAANNDDSNHQTESTESNQIILDESKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9J8</accession>
    <name>A0A0N4U9J8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MITF_TFEB_C_3_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7773</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9J8"/>
    <dbReference type="WBParaSite" id="DME_0000376801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000376801-mRNA-1"/>
        <property type="gene ID" value="DME_0000376801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10678572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000376801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="45265" checksum="6F7865732F9F23D9" modified="2015-12-09" version="1">MSKRPVPSGYNHSLPIGSGLSAHQTLNMNYAMGLLPNSSSVVQQPCVSPIVANTSTPIAVMNPTATALTANPNTTPRLNFPQNFHYQLAAMQAQAKVQQNAPANHAQLLQQMQVAQEQTNAIARAQVETQAQLACARAEAQARVQAHAQAQARAQAQAEAQANQAQAFQQSQQQAAALAQQRSLISGAVTTAHEYYYAHAQRTATNLPEYLARLAAQQHTNTVPQPTKGQPSLFVPTSEQMRLHQQQIFQNNATLQQQQQIHSQQQQIQLAAAAAAVAAASTSQRQQESSSINSIPQRLSILNTTNPQLSPQLSHSSTQYTSLPSTSTTSNNSVVANVHCNPAMGPHEDKRYHDFLVSVIQLEKQIAENLATAAVNLMSEKNTQVQSSSSTSSTIHPSSIPSSSSENVPQHHSLLQSKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB73</accession>
    <name>A0A0N4UB73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8319</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB73"/>
    <dbReference type="WBParaSite" id="DME_0000443601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000443601-mRNA-1"/>
        <property type="gene ID" value="DME_0000443601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000443601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11506" checksum="F7602DF83906DCBD" modified="2015-12-09" version="1">MPSTKESLSRLLCACYHAPKNTIAKTVISESSEGEYSKLAQKSEIQAKECDIASSESISIESISSSVENPAVIDVEQKNKTNEKIPENKDQQIAMIEVGFFFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBC4</accession>
    <name>A0A0N4UBC4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8381</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBC4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBC4"/>
    <dbReference type="WBParaSite" id="DME_0000449801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000449801-mRNA-1"/>
        <property type="gene ID" value="DME_0000449801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000008">
        <property type="entry name" value="RHOMBOID-like protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="66"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000449801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37766" checksum="02E20A7E755EBC6E" modified="2015-12-09" version="1">MFQRRRQQNFGVYLLAYQLLNSGFIPPVTLLLIVFQIAVFLEIVPVFASWTLGQICLLPFSILGKREWYRLILPVFMHADDMHLYYNMISLLWKGRRLEPYMGSRRFFFTIFCFVLGTSVMTVAISYLMDEVFRIDGISLMSQCAVGFSGVLFALKVLLNTYFPYGDEYLLGWMPVPSRYACWAELLLIQMITPNASFVGHLAGILVGILYIWGPLERFVSVIDSCFLAAWVILGLFNFTRYNGTDYYENSFHNDFNSRNTYGQRAGYSHQPDPRQTYGWRTYQNQRNFDDYTGGFSEEEQMRQAVEESLRQRANRAPGAPPYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC43</accession>
    <name>A0A0N4UC43_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8700</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC43"/>
    <dbReference type="STRING" id="318479.A0A0N4UC43"/>
    <dbReference type="WBParaSite" id="DME_0000481701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000481701-mRNA-1"/>
        <property type="gene ID" value="DME_0000481701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000481701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32229" checksum="932E1E97B21A2A49" modified="2016-06-08" version="2">IDRIRKYYILAYFDGHFNSLDHCQSKLERKVSGLSGLLISHQLYGTHPYNGSKNCFLLITAPIGYRIRLRVLDFNVLGDPKNCNKDTLHVFDHEKAIEPQKLNEVEQEEISPGPILGQFCGLIRNASELAVSTENALTLWWHSDANLPINHNGEGFRLLWSAFRKSNSEFTCDNNECIPAELACNRYPDCKDESDLSRERQIAHKCDYFDADPLSSLTGLNILLICMAFVSMLVCICICISAVPSSCVETDSQPNPPAFYPPSPPHQRMLFTESRLDCLTRNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCJ0</accession>
    <name>A0A0N4UCJ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Histone deacetylase</fullName>
            <ecNumber evidence="2 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS8785</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 11"/>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCJ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCJ0"/>
    <dbReference type="WBParaSite" id="DME_0000498601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000498601-mRNA-1"/>
        <property type="gene ID" value="DME_0000498601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF29">
        <property type="entry name" value="HISTONE DEACETYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN58812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000498601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48763" checksum="09A0FD9E794AE198" modified="2015-12-09" version="1">MPVVQEHGKRRVAYYYDANVGNYYYGQGHVMKPHRIRMTHHLLLNYGIYRNLEVYRPFPASFDEMTRFHSHDYMMFLRTATPDNLKQFNKQMLKFNVGEDCPVFDGLFEFCQLSSGGSLAAAVKLNKHKADIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYITDRVMTVSFHKYGDFFPGTGELKDIGAARGKYYAVNVPLRDGMTDEAYQSIFVPVMTKVLETFQPSAIVLQCGADSLNGDRLGTFNLTLKGHGACARFLREQNIPMMMLGGGGYTPRNVARCWTYETSIAVNMEVSDDLPYNDYFEYFGPHYRLHIEPSNATNENTPDYLRRVQEGVMENLRHLPAAPSVQMQSIPEDSTKIIENEETAKDLANPDIRLHQKYCHIYGRKEREKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCR6</accession>
    <name>A0A0N4UCR6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8871</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCR6"/>
    <dbReference type="STRING" id="318479.A0A0N4UCR6"/>
    <dbReference type="WBParaSite" id="DME_0000507201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000507201-mRNA-1"/>
        <property type="gene ID" value="DME_0000507201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000507201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45766" checksum="6CF991A1DB036805" modified="2015-12-09" version="1">MPFSDISIIINNSKCICSDLQHADYSPAYAWFNYFLIIILLPSISVFGVLANILNIYVYSRKRMQTSANNYLLFLACSDFLVILTGLFIFWLDSARSYIPSLAHVPYMTVYALPFGYMAQTCSIYFTVAAAIDCYVQVSWEEIRDNYCTVKKAMEINICITLCSIIYNSLRFPQFNLRKCFHDATQELIIEICPTALFFAINTIYNVYMYMILMTLLPFLCLSILNAMIVVRKSVKPTDLEQNVENDDDTLTMIMVVVIFLCCNTLALIVNLIETFFNPDALLLNFLTDGSNFLVIFNSSVNCLIYLIFNKIYRQIFLYAFFFKNFLIKLDIFFLYQSIRHFLIKLDLLNCSDHQLWLGNHLKYDRNIDEWLTSSSGFFIFERQKNPSISALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCW7</accession>
    <name>A0A0N4UCW7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8931</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCW7"/>
    <dbReference type="STRING" id="318479.A0A0N4UCW7"/>
    <dbReference type="WBParaSite" id="DME_0000513201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000513201-mRNA-1"/>
        <property type="gene ID" value="DME_0000513201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056771">
        <property type="entry name" value="FH3_FHOD1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24959">
        <property type="entry name" value="FH3_FHOD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="406"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000513201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="848" mass="95664" checksum="19553BBDCE3CCE2A" modified="2016-06-08" version="2">MKVLNENEASDVEMLTYGMTVINKTLNGISDQDTYYDIVDALESQGLEDAMKKMMSLGNKELMDQCKLYERVLKLEDEADSNDDSSIIFRNQPVISNYSNDRRAFIRRRHQESLIRQQEHQNFHKNHALNINANKTETSLNNNIEEQKIVPPWRKKTNEVAAEPEFHIKPSFFSTIRLNFQVQKIKPIESAIDTANSNTPKRIKMVNDDVNENNENVEPEKPVRAPPPSFPTTLFSPTENKKMEFPEVKQEPQPQEAPRKPVTKAKEDDGGGGSAFAAQLRRRAAKREQNAASYEPKQSEAEIQWKKAAESFKSKPLIINDLDFSEFHKDEFEQDPLVMARLAMIAQEKGLLPMSGSALKSSSVGGNVPPAPPLLPGGGPPAPPPLPGSGAPPPPPFLGAKPNRDSSPAPQSKTSTLKLHWKPAQDEPPPVPSLKNKGTFWHQIDLPQIDTKKLAQLFEQKTKEIQPKKLNGEQKSQILQVLSLKRSQAINIGLTKLPPITVIPTAIMKFDSLVLNKEGIEKILTTMMPSAAEIEAIEMKVAENPDMILGQAEQFLLKLSQIPCLLERLKLWAFTLDYKNCEKDIAEPLMDLQLAMKEIEESKTFRTAMAMLLIIGNTLNGTNIRGFQLDYISKASEVKDPVYKHTLTYHLAEYMIEHCPDGTDLYSEFGAVARSARVDYDELIANLEKMEQDCKASWEYLAKITDKRERNKTRGKIWALDGQEVKEGEPTPTRRRQPVQMNAEERHEMMSRMLAGGEDTLKRNRGRPTPDRTSSPNFIAAQREMLRSVGQTNSTSPGADSPDDEILDGLVKAATVQSEPRDHRRRARQFNRKSLRRTRTLKLVDDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD75</accession>
    <name>A0A0N4UD75_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9063</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD75"/>
    <dbReference type="STRING" id="318479.A0A0N4UD75"/>
    <dbReference type="WBParaSite" id="DME_0000526401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000526401-mRNA-1"/>
        <property type="gene ID" value="DME_0000526401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000526401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8957" checksum="141BB0C1EBB89C41" modified="2015-12-09" version="1">MFACGCTSLKFSMNGRFLASGFCDGSIRIHGVKKGSLRFFVHFHYNSISSIIWTLIQGKRMLVACSKDEKASLWNIYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDN8</accession>
    <name>A0A0N4UDN8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS562</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDN8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDN8"/>
    <dbReference type="WBParaSite" id="DME_0000545601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000545601-mRNA-1"/>
        <property type="gene ID" value="DME_0000545601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="72"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000545601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22704" checksum="87E3676198382CFE" modified="2015-12-09" version="1">MRNFGLEQCIRVILAWSAGLMCSFVDIIINITDIEELAHHKYQVLEDCLFYRLSEEAEKMQGKMNALMLLPPTIAAHEILDVDILAVSLKLLWMNEMWQEMNIIGFLSLSWKDRRMKWNIEEWKTNILKIRSFGQLWVPDINTDKFQMEAQAGDHLQYQNIVAKSNGNITARLEFRIIAHCDIDYRHFPDVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDR7</accession>
    <name>A0A0N4UDR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDR7"/>
    <dbReference type="STRING" id="318479.A0A0N4UDR7"/>
    <dbReference type="WBParaSite" id="DME_0000548901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000548901-mRNA-1"/>
        <property type="gene ID" value="DME_0000548901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000548901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20510" checksum="0477F338BD8ACCE8" modified="2015-12-09" version="1">MYSLIFADNGLFYFNSPQLAINVVNVDVIASLKYAKFSLILRCHIEVDTLGFERPDDLNIFSYQNFWQKYLPILTRRKRRWQQVVSPRGDLLTRFIRKGIPATLRPKIWMQNCSRVTIGKSNVDPNVIQAISLDLPRTYPNNRILASEEGQKILAHILYRLAETFPDIGYCQILKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEL7</accession>
    <name>A0A0N4UEL7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS821</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEL7"/>
    <dbReference type="STRING" id="318479.A0A0N4UEL7"/>
    <dbReference type="WBParaSite" id="DME_0000582701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000582701-mRNA-1"/>
        <property type="gene ID" value="DME_0000582701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF898">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="94"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="373"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000582701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="558" mass="64564" checksum="8917E0EAB42068E1" modified="2015-12-09" version="1">MLGEISQYSDVHHQQFNDYGSVQKLMKAFFDSMVESKNVPRRVDLLPIYDGTEYGANRHIISSLFESDIILTMDQLKGIILAEQRQENKRQKRKVITGIVYRWQTNRPIPYEFRGNNERKSSKKYEIFILKYSENWKKTIRSSLDFWEKETCLRWQENGWGNDRIIFVQGSGCYSSVGRTGGQQLISIGFGCDQKGIVTHEIGHSLGFWHEQSRADRDYYLRLQHKYIARGSEGNFVKRSIVESDNMGLPFDFGSIMLYGPNAFSNNWKHATIETINKNYQHTIGQRSGPSFIDVKQVNRLYCHGKPISFRHFDRSTATAYENQFFFLRANSINVFSDRCLTILSLPCRNGGYADPNNCQRCKCPSGLGGPICDDVQPSSCGRELIATETWQKLSHAGKEKCYWRIKTNNAKIRLHVELVSFRCEITCRSYIEIKHNWDFQQTGFRICCNEQMEVISDGNEVIVIFDATEVDRDGSFILLFIKGRENRPFRNIAGYGSGGPVERFILNFIPRVRDQRYPAISIASIVTDFTLERILSATELRKKNLLKIQTDTKTKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEQ7</accession>
    <name>A0A0N4UEQ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9402</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UEQ7"/>
    <dbReference type="WBParaSite" id="DME_0000587801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000587801-mRNA-1"/>
        <property type="gene ID" value="DME_0000587801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000271">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="505"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000587801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63931" checksum="97A4974682247429" modified="2015-12-09" version="1">MYDNSVPSKHSALDGLYSFVDEIGSGGFGKVKLAVHLLTNQNVAIKIIDKKAIGKDLPRVKTEIDALKALSHQNICRLYQYIETEDKVYIIMEHCSGGELFDYIVKKERLEESEARHFFRQLVQAVAYMHSMGFAHRDLKPENLLLTDELHLKLIDFGLCARPESGLSCTLATCCGSPAYAAPELLQGRRYFGNEADVWSMGVLLYTLLCGSLPFEDDDLSRLYKKILRGVYYEPDYLSDSSKELLRSLLQVVPKRRLTLEELIMHPWINKKYSQTLKWKSIYDVNFIFYLKFICEIKIFFSHSVNIFIYIFFKILPFYLLIISVLNLLSSPTIHASLDDELNKSGLDNDDFYEASSENLHDAVKIQGCDMNGNNDESFATAFTTPSITKVLLAFFNFFEIIFFSNFFLFKIKNRLSRSAIKTPRLKQRVFASLERQADKMINLLTPKKVKNPSPNVLKQAKTMVNISITSSKNPEIVRCELLRVFNEQNIITEQHGWKLSGRKRDEFGRVMTVELEILMIELGNKEKLVGVKRKRLCGDAFLYKKVCEQVLQLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES6</accession>
    <name>A0A0N4UES6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARF7EP_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS837</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES6"/>
    <dbReference type="WBParaSite" id="DME_0000589801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589801-mRNA-1"/>
        <property type="gene ID" value="DME_0000589801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15475" checksum="4F7C5CC85CD985A1" modified="2015-12-09" version="1">MIVLNNAKYKKIKKLAEDKISQWGFWGNVAEPIRWSCPDSQLADTERNKRLIHRHRNKLSSGQVPNKDEEMPQSSMRKIVWFAPISTRLGGSDNRNMLSKRIYQVGVPCSKCALYPCSTCEDNLCTGGGARDEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF08</accession>
    <name>A0A0N4UF08_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS932</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF08"/>
    <dbReference type="STRING" id="318479.A0A0N4UF08"/>
    <dbReference type="WBParaSite" id="DME_0000599301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000599301-mRNA-1"/>
        <property type="gene ID" value="DME_0000599301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6381420at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF364">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000599301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18379" checksum="9039BA53F3C38D85" modified="2015-12-09" version="1">FQYGTRILFIVGLSQNEDINDQVKQEAIIHQDIHQINIIESYHSMTYKARSWITHLHSICPEKKISFVVKLDDDITIDLQSLIELLTDSSIRKNFVGCRLFMKGMITRNPFISREEFPFDNLGLYCQGLAYILSGDLISKMYYNIAKVQFLWVRIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFB4</accession>
    <name>A0A0N4UFB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Endophilin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1054</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFB4"/>
    <dbReference type="STRING" id="318479.A0A0N4UFB4"/>
    <dbReference type="WBParaSite" id="DME_0000611501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000611501-mRNA-1"/>
        <property type="gene ID" value="DME_0000611501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07592">
        <property type="entry name" value="BAR_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000611501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44704" checksum="D66CFF25E5F1BFDE" modified="2015-12-09" version="1">MSFSGLRKQFNKANQYLSETMGAAEPTKFDDEYNSMEKVKVDTTYELINALIAATNEYLQPNPATRAKMATMGALSKVRGTSKSSSYPQTEFLLGETMQKYGIALGNDSDLGKALMDASEVYRQMADIKYQLEDCVKHNFLDPLAHLLQTDLKEVNHHRTKLKGRRLDYDCKKRRQTRDEELIQAEEKLEESKQLAEQAMFNLLSNDVEQISQLCALVNAQIEFHRQTLNVLESLHVKLQERVSEASERPRTEHIVKPVLTDRTPRSRSPQSNNQILNHGNVQPSAPVAAPVSVYPSTNGGEWSMPVGANTTSNFNQTSYNSATTAAVTMNTNSSTNQCKPTVKALYDFEALNEGELEFKEGDVIDLVSQIDENWYEGTLRGKTGFFPISYVQVLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD3</accession>
    <name>A0A0N4UFD3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inactivation-no-after-D protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9433</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD3"/>
    <dbReference type="WBParaSite" id="DME_0000613701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000613701-mRNA-1"/>
        <property type="gene ID" value="DME_0000613701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06669">
        <property type="entry name" value="PDZ5_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="110"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000613701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44751" checksum="01BF43A05E47C484" modified="2015-12-09" version="1">EINGVFVKSLVPQSNAYYSKKIQLHDLIAEVNGQSLEKLSHTDSVRTLVKSGSRVRLKLIRFLPGSPQADCLKMLQEQETATQVIDIQSNLRDVVADWRKKLGAEFEVISVDLIPDKSEDGGLGISLEGTVDVVDGTHLCPHHYIDSLRPGGPAAQSNALRSGDELLQVNEFILYGESHVTVRQALSKAALSAQRVRLTVARKAHTVNLFMPRPEKSLPIAYSILAASDDRMIKAKSDTCIPSARDNTALLLEMVSRRLRSQSLQLFTGLAIWKCVPMIVYLEKDSKGLGFSIVDYQDPLHRGESVIVVQSLVPGGVAQADGRIIPGDRLMFVNDEDLSNSTLDHAVAVLKSAPQGVVRLGIAKPIPVEQVSSLKKFISSSKYFNSLKKNEMAKNKSIKINKSILYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD4</accession>
    <name>A0A0N4UFD4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9434</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD4"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD4"/>
    <dbReference type="WBParaSite" id="DME_0000613801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000613801-mRNA-1"/>
        <property type="gene ID" value="DME_0000613801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06667">
        <property type="entry name" value="PDZ2_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000613801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34436" checksum="A9664A8489969D90" modified="2015-12-09" version="1">MIFNSQFSQNFEEQNSNIQPIERSILIILGSIDSQVPLGLLAVMTGNGTSSNEHRKAVALMNDGDSESNNYRSTGRIQITDQILAIDHKLLFSVPTVPLSRVRSSKSIQSFNSKRSEIVTSASEKKKKKAALTGDTKEPRISSKQNIAPCSTAFDTHQANIEPFNANVCSRKLQFFSPIEIFNNYLAEVNREQVTLALIRDSSQMVLIGEWTQVQLIRLVNEPGIGLGFGIVGGTSTGVVVKTILPGSVADKDRRLRPGDHILKIGSVHVHGMSSQQVATILRQQEAAIDLVVGRTLCNADKAGLDNSSRLSKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFL7</accession>
    <name>A0A0N4UFL7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1137</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFL7"/>
    <dbReference type="WBParaSite" id="DME_0000624001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000624001-mRNA-1"/>
        <property type="gene ID" value="DME_0000624001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841431at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000624001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25884" checksum="376EA43E8E727F03" modified="2016-06-08" version="2">MQIYGRGSLIRLILTTSIIQVNGKEAAGKKISILDVSDEPSIFSLMLAERFPQNMVTCAISQEMPKVSLPSNVSTFKFDKFTDIENAGKFDVIILKELTKESPELIGLLSQLKKLLANSEGKIILMARPKSPPLPLPEPCLQLWPKIALTREEILAACSKAKIFCTTYSASIPIKVERFDWESILFSGCFPVVKISPKCTAKEITEFCKEQSAMISFEEKISLYLLQLTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFP7</accession>
    <name>A0A0N4UFP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFP7"/>
    <dbReference type="WBParaSite" id="DME_0000627301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000627301-mRNA-1"/>
        <property type="gene ID" value="DME_0000627301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000627301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10631" checksum="B9AF9B0AE6E76343" modified="2015-12-09" version="1">MCVATGDARLPPRTHYVFGKTKIYFLCIHRHLIARNLNVRMQQFLQYLISAENRSSDHKDNLDTFAWNALSTKIVYDFTRKYVGCQKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGB6</accession>
    <name>A0A0N4UGB6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9637</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGB6"/>
    <dbReference type="WBParaSite" id="DME_0000652601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000652601-mRNA-1"/>
        <property type="gene ID" value="DME_0000652601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000652601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13707" checksum="646DF81B4035E059" modified="2015-12-09" version="1">MELQNAHGRCKPSDHFPFFLNMLGSRIFTKPGSEQRYWLYLRGVLDYSGANWCSNCHVLFDLLQLKRPYGLWSLQRKIAISRSSYMFRFFAQITIIRIISMQSYKQHLYRKVTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGI3</accession>
    <name>A0A0N4UGI3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1334</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGI3"/>
    <dbReference type="WBParaSite" id="DME_0000660501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000660501-mRNA-1"/>
        <property type="gene ID" value="DME_0000660501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000660501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="795" mass="92169" checksum="9F327677D7A967B5" modified="2015-12-09" version="1">MGSMYRSEEMCLAQLFLQTEAAYACVAELGELGLVQFRDLNPEVSAFQRKFVNEVRRCDEMERKLRFLEREIKKDAIPLLDTGENPDAPQPREMIDLEATFEKLENELREVNQNEEMLKKNFSELTELKHILRKTQQFFEEVYILKFNIYLISKNYLCMEILFFVIILGKIYNFCAIYDFQGTPVNKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVAASKNVRMWLTKVRKIKSIYFTLNLFNLDVTQKCLIAECWCPVADLDRIQFALKRGTVESGSTVPSILNRMSDSTEAPPTFHRISKYTRGFQNIVDAYGIASYREINPAPFTIITFPFLFAIMFGDCGHGLVMFFAALFFILKERQLEAARIRDEIFQTFFKGRYVIFLMGCFSIYTGIIYNDIFSKSINIFGSSWRNPYSPSVLDMRQSEDVLMFTPEWAYYNVSAGPYILGVDPIWNLAEANKLNFLNSMKMKTSVVIGVAQMTFGVLLSYQNYKYFDSHLDIYFTYIPQMLFLGCIFIYLCLEIIFKWLLFSSGYVLGRFYPSSNCAPSLLIGLINMFMMKSRPTGFVNDSGEVYPQCYLNFWYPGQSFFETVFVLIAVACVPVMLFGKPYMLWKEHKQKLQMGMSNLFDFGDIMVYQAIHTIEFVLGCISHTASYLRLWALSLAHAQLSDVLWSMVFRHSFALDGYIGIIATYLLFFVFASLSFFILVLMEGLSAFLHALRLHWVEFQSKFYKGLGRAFVPFSFEKILEEAIATEEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGP2</accession>
    <name>A0A0N4UGP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9697</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGP2"/>
    <dbReference type="WBParaSite" id="DME_0000667101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000667101-mRNA-1"/>
        <property type="gene ID" value="DME_0000667101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232779" evidence="2">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000667101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11518" checksum="EC11A104B222A427" modified="2015-12-09" version="1">MRAFIIFCLLFGAAIAVPLEITTGKYCLLCRQIINGLEEFTKMSKETIEEIILYRCQQRENNSLVCKFLVEALDKIIEFIENNVKPREACVRLRMCPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGY3</accession>
    <name>A0A0N4UGY3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Relaxase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1388</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGY3"/>
    <dbReference type="WBParaSite" id="DME_0000677401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000677401-mRNA-1"/>
        <property type="gene ID" value="DME_0000677401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9902985at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000677401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12085" checksum="ACB44934470276E8" modified="2015-12-09" version="1">MDKYGYIEAAGVKTRKFPTYTLSPISKGCTLAEKKANGERHYEERVSKHSEIYQQDARKDELLKECLKYMQTLENDQAKEIPWQNKALHGLHHWQIIDIAKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH51</accession>
    <name>A0A0N4UH51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1468</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH51"/>
    <dbReference type="WBParaSite" id="DME_0000685401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000685401-mRNA-1"/>
        <property type="gene ID" value="DME_0000685401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000685401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8304" checksum="A913BC9E820ADD3E" modified="2015-12-09" version="1">MDENERVETNRISNSPTRSSAERFSSNLPGRLFAMVQHAGSDNLSNEIVEDFRNAIDILTRVAPVNQQQINTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHM9</accession>
    <name>A0A0N4UHM9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9828</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001192">
        <property type="protein sequence ID" value="VDN59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHM9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHM9"/>
    <dbReference type="WBParaSite" id="DME_0000706701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000706701-mRNA-1"/>
        <property type="gene ID" value="DME_0000706701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000706701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="63654" checksum="EC61CB4122974EA6" modified="2015-12-09" version="1">MPTTCGFPNCKFRSRYRGQEDNRHFYRIPKRPQILRQRWLLAIGRTEETIVSQLRICSAHFEGGEKKEGDIPVPDPQLDPPISIELPPKETKNSERRRTAGLNSKSSRSTPNSSTTPSSSTSSTTNSSIKRTKSAAVTADFLATCKSGLNVSGRITNGANARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTHEIHEKVLNEAVAALMWHSITLEREDLEKFKALRVVVRIGTGTDNIDVKAATELGIAVCNTPGDCVEEVADTTLSLILNLYRRTHWLAKAVSDGRKILGVEQVRELASGSTRIRDDTLGIIGLGRVGTAVALRAKAFGFKICFYDPHLPDGVDKALGIERCFNLDDILFKSDCLTLHCPLTDETRQMINDVTIKQMRPGAFIVNTARGGLIQESALADALKSGHIRGAALDVHEHEPFDPLSLGPLASAPNIIHTPHSSWFSDASCKDLRSSAAREVRRAIVGRSPHDLINCVNKEALLLNHSRRPASSAASINPNVSTSFNSLAAAMPSFGSSIADGLSFCRLLKSIVFMMMTVRFFAYAINSYCRVVIFAEQLNGLKSGKSLFKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHS9</accession>
    <name>A0A0N4UHS9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9854</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHS9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHS9"/>
    <dbReference type="WBParaSite" id="DME_0000712401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000712401-mRNA-1"/>
        <property type="gene ID" value="DME_0000712401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF15">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000712401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="55722" checksum="30BDFA81E55FC6CF" modified="2015-12-09" version="1">MRNIVHFLVEDWCLSAMLGIITAILSVTVDVIIERNNYEETFSVHVALYSVILNYNVYLAMFQWVFHVVFLTFLSSLSCLIISRQAVGSGIPEVKVIMHGFKMKSYLTFRTLIAKMVGITLAIGSGLPIGKEANFFIELYGPFVHMGAIVSTILRKITKACHYSAFFTNEGHEMEMLSSGCAVGIACTFSAPVGAVLYAIESTSKYFAVKNYWRAFFAATCSAIIFRFANRFVTSDQSGAITAFYQTKFPTESFVVEELIIFAILGFFAFTVFMSLVVGIITYPQGFGRYIAGKLTFRETMADFFSNCTLHITGNSWQACDEKMLEHWLGGSERDISIFFILVAICISINVPAGVFVPSFIIGAAGGRLVGEFMSYMFPEGLRGPDGPLIYPGLYAVVGAASYTGAVTHTLSVAIAILVGNAVCKFLQPSIYESIIKIKKYPYLPDLPPSRMSVHTVKVEQIMVQEVIFITKKTTYKELREILRLAPNLKSFPVVTDRGIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHU8</accession>
    <name>A0A0N4UHU8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9878</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHU8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHU8"/>
    <dbReference type="WBParaSite" id="DME_0000714801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000714801-mRNA-1"/>
        <property type="gene ID" value="DME_0000714801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="180"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="412"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000714801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58675" checksum="D44A2343BA59C229" modified="2015-12-09" version="1">MADIEDDLFAPLAKKESMAIVKVKRRLKQENIFFEGDSFVPGTHSIFVKTWGCAHNTSDSEYMTGLLTAAGYHITSSKARNFISESASLWLLNSCTVKTPSETQLENLVKEAQNMGKFIVVAGCVSQAEPNAQFLKNLSIVGVKQIDRIVEVVEATLEGNCVRLLTRKRPNQRLALPKMRRNALIEVLAISTGCLNRCTYCKTKLARGDLVSYPLEDLVEQAQSAFSDGCREIWLTSEDLGAWGRDIGMVLPDLLNALVKVIPEGCMMRLGMTNPPYILDFLEEVAKILNHPRVYSFLHIPVQSASDAVLSDMKREYDCADFCVVMDYMLSNVPNIYIATDFICAFPTETVEDFEESMELIRKYHFPSVFINQFYPRKGTPAACLKKIDTVEARRRTSQMSALFRSYSRYGETRIGEIHRVLVCEQASDKIHYVGHNKSYEQILVPGDDASILGHFVDVKIVEVSKYHMKSCLIKKNSNTVMKFFSNIVTNFYRNYHPIATALFSVFVFLFLYFNPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UID8</accession>
    <name>A0A0N4UID8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1727</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UID8"/>
    <dbReference type="STRING" id="318479.A0A0N4UID8"/>
    <dbReference type="WBParaSite" id="DME_0000736501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000736501-mRNA-1"/>
        <property type="gene ID" value="DME_0000736501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF295">
        <property type="entry name" value="SODIUM: NEUROTRANSMITTER SYMPORTER FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000736501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70915" checksum="75DBAC113E952C06" modified="2015-12-09" version="1">MWFEERSWSNFKMPTLLSEEWRDLWSIKVDMIVASLSYVFATTNFLNLTRLILENGGLAFIVAYCTSIFLCILPILILEFAVGQLTGKAPIQAIYNMCPIFRGVGISQIIFSLLMLSHMARYLGWLMLYLFHLFWTILVDRPGLPWLNCKGYPELHTVPCREAGTLSNFTHISTTKLNTISAQSSLIQFMTILERPSDNISEIGHFQLYILSSMAVVWIIVFISICFGIRWLGKIVHFTFIMPVVLLSLLMVRALTLRGLIEVLKKFYLATNWNRMADYMLWKTASEQAILASGVGFGVFITIASYNKRSNNLVGDCLLITFGHLILTFMQVMTIIGLVGHISARTGLHPIHLLDRGETQMWHILAYMSYLSDTRIWTSIVLFMSIFVLLNIFYLLSLNILASFEDACGERWSKCFPRFFLSFIVCSLGFACGLYFATQGGFYAYELAGGFWKYVTLWTILFFELLAVGWFYCAHRLGKDLHIMLSNACSWCFGHFLLFFIYLLPAVPAFIAAVNLLNYDYSLYTSGVHEWKYSEMVGWIIALIPLLPIPLFMQYTICKTCLKGPGVTKWQRFKNALASPVHYDVVKTSSPIKTPRFTNNAPGYILLPQAPLAEPEIYNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UII5</accession>
    <name>A0A0N4UII5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Abhydro_lipase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10056</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UII5"/>
    <dbReference type="STRING" id="318479.A0A0N4UII5"/>
    <dbReference type="WBParaSite" id="DME_0000741801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000741801-mRNA-1"/>
        <property type="gene ID" value="DME_0000741801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000179">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229983" evidence="3">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000741801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51018" checksum="F98CAA5979B7914B" modified="2015-12-09" version="1">MLLHIIVFTLLYWNISSENLVKAIELTVLNPAATPNIIDAWGYPLHSVKVKTEDGYILTMHRIPYGKEEMRKPCNARPVVFLQHGLEATSSNFVTNLPNKSLGFLLADNGFDVWMGNVRGNRYSREHVNLTANDKSFWKFSWFDMMKYDLTAMIDKALELTNQSHLYYIGHSQGTLIMFSKLTNEAHFANKIRKFFALAPVATVKHIKGLLALFADNFYWALEVFTLISNYCWYRKTNLLSKTFQKWFGTQEFVLNDTLMDVFKNKFCDSYRLNLACVNLLSMIAGLESGQLNETRLPIFLSDLPGGTSVMNVINWIQMVRNGAVQAYDWENPEENIKHYGQNNPPIFDLKKVDVDMYLYWSPADWLANQKDIEEFLLLNLNMTANFHYKISNSIRDIFNVKLKKFNHMDFLWGERAANEIYKPIIDIIKGDRMVGKTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIL8</accession>
    <name>A0A0N4UIL8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beclin 1-associated autophagy-related key regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10022</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIL8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIL8"/>
    <dbReference type="WBParaSite" id="DME_0000745301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000745301-mRNA-1"/>
        <property type="gene ID" value="DME_0000745301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820935at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000745301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="61354" checksum="717AE9A71AA43A3C" modified="2015-12-09" version="1">MLTSSQMRELNSDSGDASCSAESTNGISSSISDKVNPDEELCPLPPDRNSFQLLQIDNIIGKNCEGILLTLRNKRIPLRLRRDELRDEINVRKPEIVELRKQLDLKNRVISDIENDLVYKREDRLNLRLSKLEETYNRKGFTSIRNEQALVKEIDKLKRNRMKLEKYNSLLEERRIIETKFREAKAAQNRILRLIRQIACELQSINQQIGHHHKDLMDMRKLLQEIYINKKELVEKYNGAKEIYLAWLRNNRNEKMRFSGPSVCNHSYPATFPVVSRQHYQKPYDNEDEEQLLEPFYEQKMSCHRVINYLECIRPHMETTNRFPNLDSSTSTAVTFCHSVEESDDSAEEFPPAMAILKKHASLPARPTYIGPACEKEIIPGIKGKKKMNKKSSKKPCQHINHPLEIIRLFNDLGVDLPLCYKQIDRVLDEVRELLDFYKQQTNIVVWNESDYCHFLSESECTADSAWNGSTDMSEPGSLRSYQLMSSSDIVSPTEPIVGSNVPPSSSCNQLVDQVVCLSVNDEGIDSKGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIM9</accession>
    <name>A0A0N4UIM9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1757</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIM9"/>
    <dbReference type="STRING" id="318479.A0A0N4UIM9"/>
    <dbReference type="WBParaSite" id="DME_0000746401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000746401-mRNA-1"/>
        <property type="gene ID" value="DME_0000746401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="131"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="450"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000746401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="682" mass="77255" checksum="CF118D33AC177297" modified="2015-12-09" version="1">MFRSRSKQKLVQISLLSQIWKVPRRTQPCYKPWNKYGIATSAVDFALYLLLRSVLDELRDQKIEQFAEKLTGQDLVDFVNKKQNLWTAKLYSKFESLSNRVKRGMLGVKHMALSADERRNLSPTRFSSMYIPEQFDSREHWDMCPSIKNIRDQSSCGSCWAFGAVEAMSDRICIASKGKIHVSLSADDLLSCCRSCGFGYADYHIKLSEPMEAWQYWVHNGIVTGSNFTSHDGCKPYPFPPCEHHSNKTHYKPCHHDLYPTPKCEKTCVPSYHDKSYLQDKFYGEHAYAVEDDVLSIQKEILTHGPVEASFEVYEDFLTYGSGVYKHVAGAFDGGHAVKLIGWGIDQGVPYWTAANSWNADWGEDGFFRILRGVDECGIESGIVAGLPKLPKLNGTDAKSKDKFDEFAKLNKRFASLTKDELRRFFGAKKLNSLKKAKFAAEENYANIDIPKSFDARDQWPLWSCWAFGAVEAMSDRICIASNQTKKVTLSARDLLSCCNECGDGCDGGFPLLAWEHWYNKGIVTGSDYISNTGCQPYPFPECAHHNNNSHLPPCNANLYDTPTCKYECSNSYSKSYSSDKYYGEATGNRPFSLLENVTRIQLEILNNGPVEAAFDVYSDFIYYEKGIYKHVTSDTIGGHAIKIIGWGVENSTSYWLIANSWNAEWGENGQNFFSYISNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIV3</accession>
    <name>A0A0N4UIV3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amidohydro-rel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1820</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIV3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIV3"/>
    <dbReference type="WBParaSite" id="DME_0000755301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000755301-mRNA-1"/>
        <property type="gene ID" value="DME_0000755301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF48">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="58"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000755301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50599" checksum="0E46909AA4D427FE" modified="2015-12-09" version="1">MAKSCLRGKVITANFIWTGNTFENGIQMRIDQNGFISEIGKNLFKGSEELFDFGQKALIPGFVNSHSHAFHRYMRGRSHIGSSYKDSFWKWREDMYSVVEHIDEKMLYECTHATFTEMLSAGITTVGEFHYLHHGKKRFSLDQIILNAAQDAGIRIVLINTLYCNAGFDGSPLTEAQKKFISSVNEFIENIELLQQRTKQLQTIAVAAFAFYRMLFYFVKQVTGFIIAHSLRAVSVEDISILSKWCQKTGRPMHIHLEEQQKEIEDCRKIYGCDPSELLLQNISHYVNITAVHCTHTTTNLMQLLAQNAINICICPLTEGYLGDGIPNIVDEAHICLGTDCNNRICMLEEMRWLTYCQHMLHHTRNACGLDARKLLCIATENGAKSLGIENLVGRFSQGMQFDFVAFDLCSPRLGQQFDDLLDAIVFGGGNGDIALTGVSGMIVFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ84</accession>
    <name>A0A0N4UJ84_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CSN12-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10138</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001203">
        <property type="protein sequence ID" value="VDN60165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ84"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ84"/>
    <dbReference type="WBParaSite" id="DME_0000770401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000770401-mRNA-1"/>
        <property type="gene ID" value="DME_0000770401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000770401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26918" checksum="FB33C7EB4FFE3B51" modified="2015-12-09" version="1">MEVSKKVAMLNLTNHLFRIYFRINKLNLLKPLIRAIDNCGHLYEFFSMSDKITYKYYLGRKAMFDSDLKLSEHSLSYAFRNCPAECHRNKRLILMYLIPVKMFLGHMPTIQLLIQYQLEQFSIVVETFARHEDFFVECGIFLMLEKLKIITFRNLFKKVSHFVGSHVIPFDAFMCALNWLGIDDIDQDELECIIANLICEKKIKGYISHQFKKLVLSKSSPFPPLSTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK63</accession>
    <name>A0A0N4UK63_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2216</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK63"/>
    <dbReference type="WBParaSite" id="DME_0000809101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000809101-mRNA-1"/>
        <property type="gene ID" value="DME_0000809101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000809101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16459" checksum="AD7202D9582C1C43" modified="2015-12-09" version="1">MAIAREVLSRAAISARIIVTSPHLSVMRLNLASPAIIPRGKCVAQYRRISNVIVLFSFEGGGGKGGNFFKNCLWFFISNALSSIITYANTRSSGVRDVLLSRFSTLVHGNLYGLADATRWMQAAIDIPCYVSALVIPAQDKLVAAVQLSQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK89</accession>
    <name>A0A0N4UK89_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK89"/>
    <dbReference type="STRING" id="318479.A0A0N4UK89"/>
    <dbReference type="WBParaSite" id="DME_0000811901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000811901-mRNA-1"/>
        <property type="gene ID" value="DME_0000811901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000811901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9574" checksum="6676D2BBD0CE4CB4" modified="2015-12-09" version="1">MKIGERSSSGHYLGIKWCPLEQRSCKRHRRLLIQTYLPWCIEQAVNGRFLLAFDWENHFEKDLSDLQKLCSIISLAEYCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKC0</accession>
    <name>A0A0N4UKC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2232</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000051">
        <property type="protein sequence ID" value="VDN52259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKC0"/>
    <dbReference type="WBParaSite" id="DME_0000815601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000815601-mRNA-1"/>
        <property type="gene ID" value="DME_0000815601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000815601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46007" checksum="3C17A445187F8FDC" modified="2015-12-09" version="1">MLNSLLLYHSSFNLRTNSKKSIEKNANSIKGIVIGIHQQFVEIVPISKNSGKSLPSITLSDLQNVKLGDWIWLIGLDQNKFVYDRHISENERPFITKVVKNSVMLLTKLSFPGPSMSGYKKWAMSPVFGKVAAVEHEYTENVETSPRLKNILKYEWMITKYIFQHQEHQKSSELNEASVVINNSKKTIKNDITLPQSFDTNNSHYIMYDEMGFGAMREPYGERNFDGLITVICGDLVLVTLTGYISRIYSTKCLDSSIPLKVGNWVNVRGEFFPDMFRVILRDIPKRIKPVLPTRLFNGSAMILTAINGTEYDGDTMVGYSVKLGKIFDVNKFLQDGDIGNKVLVWCYLKYLSDENRVIWAIRFIEKRFYPLAQKIPNDKPCKTQAKPKKIYSKLNFPTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKC9</accession>
    <name>A0A0N4UKC9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2242</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000051">
        <property type="protein sequence ID" value="VDN52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKC9"/>
    <dbReference type="WBParaSite" id="DME_0000816601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000816601-mRNA-1"/>
        <property type="gene ID" value="DME_0000816601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000816601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10553" checksum="95220EDF74DA9F76" modified="2015-12-09" version="1">MITVEFGMDTVGPGIDNEEFCMDIAKFGMGTDILHDTIGFGMDNGGFTMDIDGYSVETNGFNININIDLILINRYTNRYHQINFKFSIFSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKP6</accession>
    <name>A0A0N4UKP6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10339</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKP6"/>
    <dbReference type="STRING" id="318479.A0A0N4UKP6"/>
    <dbReference type="WBParaSite" id="DME_0000832201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000832201-mRNA-1"/>
        <property type="gene ID" value="DME_0000832201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="13">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000832201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36464" checksum="65785F2BD892864B" modified="2015-12-09" version="1">MNVEYKSSSSSLSTTTTTTTNNSTNALINSAANQGIATPQPKTVGRVQGSTPSNCLGGPITTQSVAPQFSIPTPQALTQNANPEVLSAFECPVCMDYMMPPYLQCQSGHLVCGNCRPKLTCCPTCRGPVPSVRNLVLEKIANTVMFPCKFAASGCPLTFSHVEKVEHEELCEHRPYCCPCPGASCKWQGNLSEVMGHLMKVHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGYHFMLVLEKQEKFQDGNQMFYAVVQLIGAKKESENFMYRLELATHRRRFSWEASPRSIHEGVAHAISLSDCMAFDTQTAQLFAENGNLGINVTISMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKR7</accession>
    <name>A0A0N4UKR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2352</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000056">
        <property type="protein sequence ID" value="VDN52379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKR7"/>
    <dbReference type="STRING" id="318479.A0A0N4UKR7"/>
    <dbReference type="WBParaSite" id="DME_0000834601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000834601-mRNA-1"/>
        <property type="gene ID" value="DME_0000834601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="114"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000834601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55320" checksum="B2327A39518F867E" modified="2015-12-09" version="1">MNSLEHKNRERRVPTSRIARLASFAQLGFGLATGAAAEMIRRSFSGVLQVLQEENKTENSSNSWQSSFVTPANAEKIVLTLCKVRGAALKLGQMLSMQDPETVSPVLLKIFERVRDSADFMPIRQVITQMRNNFGKNWAENFTNFDEKPFAAASIGQVHRATLLDGRKVAIKIQYPGVAHGIDSDIDNLINIMNYTNFLPRGLFLQNFADAIRQELKLECDYKREARSMKVFRYLLRNDSEFYIPEVVDHLTTNQVLTADFVEGMPLDKCAEEQQQVRDYIARKLIELCMKEIFIWRFMQTDPNWSNFFLGRHPTTGEPRLVLLDFGASKSYSKNFIDSYMHILRGAYKKDKKKILKYSREIGFLTGYESEIMNDAHCESIIILGETLASTVPYDFSRQDVTKRIHRLIPVMLQHRLKAPPDEIYSLHRKLSGSFLLATKLQATVSCGPIFSNISENYNFGETSQMIDIDSENCLEIVYNQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKU5</accession>
    <name>A0A0N4UKU5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS2383</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKU5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKU5"/>
    <dbReference type="WBParaSite" id="DME_0000837701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000837701-mRNA-1"/>
        <property type="gene ID" value="DME_0000837701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN52410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000837701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44327" checksum="ACEA4CF21BDB7367" modified="2015-12-09" version="1">MIIINFLAEILVKNLLGDLIGFGQSGSVYELWLATASKNATSSSEVSEFHSSKESSLALKAIHNFDFNQPVEHSLDENRCELLPLIDSNFLGTGVMMRCRLKISHPNIVKMHAAFFDDWKPFQRMEEEFPALLPTKDNYMCIPINPKTLYIVMRRYNMSLKDYLSSISIDYRIGRLLFSQILEAISFLYDCKISHRDLKFDNILLEFDSDDQCPHLVISDFGHALSTDTWQLHYVNDGISLGGNIAHLPPEVTKACPSPNTWIDYSKADIWAAGLIGYEIFDKQKLIFSVRMLDSFVMLSDTNQHFMPLFLNSPVGRIMQAMLYKDPSKIGEHLQNQIDWLISIYAAEAIISKCIDPVEAELRNTFLKRYCVNDIWMAIDFFFERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKZ4</accession>
    <name>A0A0N4UKZ4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10382</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKZ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKZ4"/>
    <dbReference type="WBParaSite" id="DME_0000843801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000843801-mRNA-1"/>
        <property type="gene ID" value="DME_0000843801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="13">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="14">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000843801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38642" checksum="CF0F4A0863F7D06E" modified="2015-12-09" version="1">MRYLKMWMGTHRNGPSSICSTNMPLAEYISINKTSLAEHENGNIGFLFKVLSVNKPLSIQSHPNKEEAKVLHARDPTHYPDDNHKPEMAIALSDFELLCGFRPSKEIYDNIKSLYISCIERLTDSNEEKQREALKIIFSDMMNSATDVISTAINSMVEQGTHSSFDKLLLRLNCEFPNDIGVFAPLLLNYFTLKKGESVFLEPNQPHAYLLGDCVECMACSDNTIRAGLTPKFKDVKTLISSLSFKMSPPPYFLAKKLRPGLVEYRPPVKEFAVHEIKHDFDGSTDIGSSSILIVIDGKAKFVADKEEIFVNKGEVVFLPNNAFVSSIVSSENFLAYRAFTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULK2</accession>
    <name>A0A0N4ULK2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2595</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULK2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULK2"/>
    <dbReference type="WBParaSite" id="DME_0000868001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000868001-mRNA-1"/>
        <property type="gene ID" value="DME_0000868001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984255at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000868001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43862" checksum="EF99C1F5E7087EC7" modified="2015-12-09" version="1">MTFDILSWTDPMRETLIKNFQKNECLWNIIDVDYRNIAKKRQILCDMAKEMSETFGVCIGIGHLNRQWQSLRDQYRRAKKKLENANGHMKPWRFLQMLKFTDTSDSADITDPLTVYSSLVWDEASETAQHLSYPSDRPFSTPSASMFDNEIGDSITYNGRSAKRENDTIVTFSAASSEVTSVHPSFNSSVKNITVTCSPTVAQEIYVHGHAEEYSNGGANEILGSMLAGREHDSPAPSDSSIENRNDKQLVDRSSVPTISTGEIKVENQYMTGRKRLTQNSLYHGVDKRSRFSEENQLDDYDEFITFSRTVEKKLGLIACRNRRLYLIAQKKIMDCLFEAEFELLEHEANLIQIMFLSYFNKSFSDEESSEFQWAKMINEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULS0</accession>
    <name>A0A0N4ULS0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF2431 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2648</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULS0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULS0"/>
    <dbReference type="WBParaSite" id="DME_0000875701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000875701-mRNA-1"/>
        <property type="gene ID" value="DME_0000875701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="3">
        <location>
            <begin position="101"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000875701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49660" checksum="9EA922431699FD7D" modified="2015-12-09" version="1">MEKGNKGKGKNKSKDHGPRTDDKLFDAISTAKETLMKALDGKECTGMDINLVEEIISLKEENRAIIKELENLREKVQNLLQLIQRLTFNCTPLLKPSRRVLILGDGNFTFSLAFCQLHHDVQIVASAYETEKEYFKRYPLAFNTILSLLNYYPRVTVHFGIDASCLPEIWRKKFGDIIWNFPHHGGKSNMRLNRELMQRVLASVSNIFPIGRFSITFAKNQSGLDHDSVCNKRIFKANCLPKHVSDSWQIAYLAAKYDFDIFSINKFDPSQFPGYIASGYRNRDRFFRNNIRAETVTLVLSPKITTLFGMKIYEKSIIKFSNIYHEFRPFFQHDLSIIYRDVGNILYWEGKFYDMIAYLCSSLVLSIRELKELRSTAPSGFPNRIYRLVWQSWNKAMSKSLSNALQEQLRIAIIARIQKKFYKFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNN7</accession>
    <name>A0A0N4UNN7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3208</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000113">
        <property type="protein sequence ID" value="VDN53235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNN7"/>
    <dbReference type="STRING" id="318479.A0A0N4UNN7"/>
    <dbReference type="WBParaSite" id="DME_0000952201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000952201-mRNA-1"/>
        <property type="gene ID" value="DME_0000952201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799552at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="155"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000952201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46811" checksum="22E84CC9CEACAE4C" modified="2016-06-08" version="2">MENILENIGKFEKCSICGDVADGYHYGVLSCRGCNAFFRRAVTYGIKYCCRREGNCLVDKSFNYLNLFFGLSDLIFDYYAILIILGARCACRACRLKKCEMVGMDRRAVQPKRESGFKQSCSSFSSYKQTMPNYDINPVISLRNASFIECLVNDYNEQKIRRHMMLCSCIEEILTDNIEKILKKPAIGFDYLIIFKVQMVLMFEWVFKLEDFRSIESALDKAQLLRAFALRYLLLDNIFHTVELGYHDKIILVNNSYIVPGNPPELSDEKNQNRAIQTMMYGENSFRLITELIVPMIQMNLTAGEMMALRLIIFWNLNGLSLSSKTKSIAQSSSNRVVIELHKWYNEQKFEDTDTRFGNLLLFIPLLTVCLFALISFLFIFLFYIFVPGSLHLMLYYIRIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW9</accession>
    <name>A0A0N4UNW9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3281</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000119">
        <property type="protein sequence ID" value="VDN53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW9"/>
    <dbReference type="STRING" id="318479.A0A0N4UNW9"/>
    <dbReference type="WBParaSite" id="DME_0000963101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000963101-mRNA-1"/>
        <property type="gene ID" value="DME_0000963101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835337at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041161653" evidence="6">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000963101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24216" checksum="0568D0882D425D8B" modified="2015-12-09" version="1">MSNLIAALTAVAFGILLFSIEDEWRQLIRTNLQYSIQKSIENNEFADEINRIQSLFQCCGLSVNGSEPKEIWLTLLKVDMAFKNELFRPYKMLPWSCCRHNHSYCDHLAFERYYTQINANVYKKWPSYTKHINEKWECGSLENCKNKRKLAQVSLNNRDCSESFVNSFQTVIFHWNGSCAIVLGLQMLFTSITAFFFELTDARANYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP86</accession>
    <name>A0A0N4UP86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3372</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP86"/>
    <dbReference type="STRING" id="318479.A0A0N4UP86"/>
    <dbReference type="WBParaSite" id="DME_0000975601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000975601-mRNA-1"/>
        <property type="gene ID" value="DME_0000975601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000975601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24772" checksum="5655FA2541271495" modified="2016-06-08" version="2">MRNVDQDFWDDSLLIKMYDEARETTYRKLKNSSLGVKGCSQNNHEKQWKVGDRCLAPYEDSLYYEATISHIISSGLECQVEYDGYDGEYWVDVCELKKLSCEDEKKTLSDCKSDGRSDVKKQKEIRHESKSKNLRLKNYHQSGSQLFEESVHFMPSFIPPPLPVFNGLKVNNEDEALGSMLMSWYMSGYHSGYYAAIRDQKNAESCESSSNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPC9</accession>
    <name>A0A0N4UPC9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3411</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000131">
        <property type="protein sequence ID" value="VDN53438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPC9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPC9"/>
    <dbReference type="WBParaSite" id="DME_0000980701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000980701-mRNA-1"/>
        <property type="gene ID" value="DME_0000980701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000980701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53115" checksum="49EF6FE9CE61A516" modified="2015-12-09" version="1">MTKEITGSNKVADLEIEIKTCEKSRGLGWFTTALFLVADLAGGGIVALPIAMLQSGGYIGVIIIIALSIGFCYTAHILGENWTIMCERWSDYEEHCRKPYPEMAYRAMGRRAKSICSGILNVMLFGVSVVYLLLAAHIINDFVTSIMGRNIGFCFMIVILAFVLHPVTLLKSPQDFWWAVIGAMFTTVLSAILIMIGTVLDAPICYHARGISEFQASSLVLSFGTFMFGFGGHAVFPTVQHDMKNPYKFTKSAIVAFALVTAMYGPISILGYNVYGDSLESSIINSIQTEWIQRGANLFIAVHCILTLTVVINPLNQEVEHLFNAPHHFCWQRILIRTVVMICVIFVAETVPTFGPILNVIGGTSVALTSAVLPSLYNLYLKAAVFDESTKKYRRPTLYKIIERTPKMRLTLNVIIIVLAIACGASTTYSAIIDMVSTRFTMPCYLSYLENATSVHENPTHCCGRFKNISRFGDSAKYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPD1</accession>
    <name>A0A0N4UPD1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3414</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01000131">
        <property type="protein sequence ID" value="VDN53441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPD1"/>
    <dbReference type="STRING" id="318479.A0A0N4UPD1"/>
    <dbReference type="WBParaSite" id="DME_0000981001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000981001-mRNA-1"/>
        <property type="gene ID" value="DME_0000981001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000981001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="609" mass="70711" checksum="CC71544D8137B074" modified="2015-12-09" version="1">MTRRNLSFLKRKSNRDSRLLDREDVPRGPISPLFGPKIYTESLFGLKSKLYVPSAEMDLEWQPTIGSVFKVLFSLRISAAMWSTISDCDETYNYWEPLHLFLYGSGFQTWEYSPLYAIRTYLYILLHYIPGFLLKILFSYNKIGVFITIRCILGLFNACSELVLYKALCNRFSNGIARIYIILTIFSSGMFISSCAFLPSSFSMSVNTFAMAAYINNDWFISIFCTAVSALIGWPFAAILGFPIVIEMLIIRYRQFSITFAPLNIVLYNIFSSHGPNLYGIEDIKYYLKNLVLNWNLVIFLAPFAVPFSCFAFVRTRSSRQLSQRVPIRLSFSYWQRFLPVLFISLSVALWMLIFFSQPHKEERFLFPIYPLIALLAAISLDAIPRVGSFLVGGNTRKFWNICVGLCLTIFIILSLSRSVALHRNFSAPVQIFKALNERFTDPVYIEKSRISSQSNSSLVHICIGKEWYRFPSSFFIPLQIIDRRNRRWKVELNFIKSEFSGILPKPFAKENLPYATRIIPSEMNDKNIEEPSRYIPVNMCDFMVDLETPDITPLEPNFAKQNDMWKSIVKKRFLLSAYSHSFLRAFYVPFFTASNIRFSNYHLLERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPF5</accession>
    <name>A0A0N4UPF5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3423</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000132">
        <property type="protein sequence ID" value="VDN53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPF5"/>
    <dbReference type="STRING" id="318479.A0A0N4UPF5"/>
    <dbReference type="WBParaSite" id="DME_0000984001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000984001-mRNA-1"/>
        <property type="gene ID" value="DME_0000984001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778665at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF1">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000984001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34811" checksum="4105ECDBF0AC7802" modified="2015-12-09" version="1">MLRIFETVQELCEALELTTGSVYLLPIHYCIRHEVLNIFPEAKCVVFAYPEQSPRFWMVIRRNMYTRPHVFMATRSQLMITDHEIDTFLIKIRPYLLELSDFYARILGLRLSNRMTSILAGQFDFSSQNYLANYFIIEESKQRQIAKIEVVLPEGYEFADLDPERDSEFVTACWKFSTSGDREQFAAKIRRLPSVGIKANDGSWASFTVLDAAGYFNNQYTYEKHRQKGLANMSEIKLCQKVLNFGLCPLKFVEHENVIVSARSARSPWWSTVVDEAGIPVVHDHRLVRQRSELPIEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPX3</accession>
    <name>A0A0N4UPX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3579</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000152">
        <property type="protein sequence ID" value="VDN53606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPX3"/>
    <dbReference type="WBParaSite" id="DME_0001003501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001003501-mRNA-1"/>
        <property type="gene ID" value="DME_0001003501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001003501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8435" checksum="224A4796F194FD35" modified="2015-12-09" version="1">MTDEDGIRFKDGFKDGWRSIGFSQVRYTGRGIRMECLRPPSRCASVDRGCARTCQSIYVLCHEHSLIDKCRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPY4</accession>
    <name>A0A0N4UPY4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3573</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPY4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPY4"/>
    <dbReference type="WBParaSite" id="DME_0001004601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001004601-mRNA-1"/>
        <property type="gene ID" value="DME_0001004601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001004601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48028" checksum="1720BA62162507E7" modified="2015-12-09" version="1">MAAIRSVRFSEFPAVKLHSAADVKPDKTNKFVVQFPRIYDDALFGPYDVYTAASIGDVEIVEAQLQSGFDPNRLNSSKWSALMYASYLGHDNICNILIKHGASVNLTNGKGQTALMLASCCGNVAVVKQLISKGAHIDRQDELGDTALGYATACSQSTVVEILLEAGADPNMPNNAGMTPTLTACSIAHEITLITLLKNDGDARIKNKKGEDGEILAFDNPKAIAIIKDPPMNKGASKRKGSEIKLLSDLLQQLNLEKYIPIFEAENIDLKLFLQLTDTEIAEMGVKVNACNSRKKLQAFGPRKKMLNVIDRYRKDGTILTNIDPEIKHEMIEERVRNKVKSRSEQVTNELMECQQNLAECKQELHKAHKIIHEQQNVIKAISETGKISRELAYAMLEEIKHNSDYARFEKGVSSLIKNIDNMAMKVLELSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ44</accession>
    <name>A0A0N4UQ44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vps16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3633</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000160">
        <property type="protein sequence ID" value="VDN53660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ44"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ44"/>
    <dbReference type="WBParaSite" id="DME_0001011101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001011101-mRNA-1"/>
        <property type="gene ID" value="DME_0001011101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977282at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spe-39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364">
        <property type="entry name" value="DEFECTIVE SPERMATOGENESIS PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364:SF6">
        <property type="entry name" value="SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001011101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="59292" checksum="48855F28A3850B3C" modified="2015-12-09" version="1">MEIHRKFTFDNPEDSYWNANGPANSSLFDEVPFNINAAAARNALEDLFESQVRFKNEKVASEDGSIYRDDYGHTLTNDHISLKLKVSEQETEIPSVTHIKAIPSAASIVSESSAGSFSSEPTTQLDYLRLKSEHRKLQKHLEYVRHERYRPAEPSVTVRRLICGEPVSFDLYRSKEDKMDLLDAAVDSLDGNAIIAVVLFLQRTLSERLFREILLENVVATTHYLSYLKQIKDYNQIIITLMSLGRYIEASMLELSIACNQKISEDRIQCLKCCFSKFIQSPTEHESHEAKLLSEHISLLERQIAIDANDEMECREDKEEKFEEFRKIASSLIQQPLLTTIYYCCFYHYDLAVNSFASPLSLKEVFQVTEKQYVWMAVSALSALRRWFDIERILTEKRSLSDSKIICPFGWNHLFAIILQNGEPPKEILCKLLRAIPSLKERRQFAELFVGGSDVVIECLLAQKDRINLKNFTAKLSPHTAETSKAVNAVNNIVSFFLFWMSFLYIKLHTNHTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQT7</accession>
    <name>A0A0N4UQT7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10892</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001267">
        <property type="protein sequence ID" value="VDN60919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQT7"/>
    <dbReference type="WBParaSite" id="DME_0001039301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001039301-mRNA-1"/>
        <property type="gene ID" value="DME_0001039301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162714" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001039301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8068" checksum="E95B336E961D9828" modified="2015-12-09" version="1">MLLYFCFFVFLVYGARSGDDKAIENCNIQVGQHQRPTVDPSRCAHIDSPACTAIFPYHPPNNAGATIATHFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQX4</accession>
    <name>A0A0N4UQX4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3893</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000211">
        <property type="protein sequence ID" value="VDN53920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQX4"/>
    <dbReference type="STRING" id="318479.A0A0N4UQX4"/>
    <dbReference type="WBParaSite" id="DME_0001043701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001043701-mRNA-1"/>
        <property type="gene ID" value="DME_0001043701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865326at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001043701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19545" checksum="E3C175AF315AC3B4" modified="2015-12-09" version="1">MDTACRYSRDIRISPEHRIRDLEYADNVVLFADSYNEMQVILNNVSETAARIGLRINVNKTKAFSSYVQKVDKMPLFVNSLPVEEVPDFKYLGSTLTANGQVKDITTRITAARNAFFQLTKSLWSRREITIKTKARIYIAVIRSILLYGSETWPMRVEDIKKLSAFDHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR86</accession>
    <name>A0A0N4UR86_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3989</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000240">
        <property type="protein sequence ID" value="VDN54016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR86"/>
    <dbReference type="STRING" id="318479.A0A0N4UR86"/>
    <dbReference type="WBParaSite" id="DME_0001055901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001055901-mRNA-1"/>
        <property type="gene ID" value="DME_0001055901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN54016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0001055901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13892" checksum="92216045A83B8F0E" modified="2015-12-09" version="1">MALITRAEVTEHTSGKSAWFVIGNKVYDITKFMDEHPGGCEVLLEQSGKDATEAFEDVGHSSDARKMKENYLIGEIISVSLFFYFFHNIEFGIEIFFSAIDGFFWPSLIIIILAFLFYLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US86</accession>
    <name>A0A0N4US86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000681">
        <property type="protein sequence ID" value="VDN54337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US86"/>
    <dbReference type="WBParaSite" id="DME_0001091801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001091801-mRNA-1"/>
        <property type="gene ID" value="DME_0001091801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001091801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13094" checksum="4DAA7EAEF23A98C6" modified="2015-12-09" version="1">MRRVNFSQTCDTSNVEIEECVKLVGDKKRPTVNSCPEDPVCSSIFVYDQRAPDDLVNNLREDQDYKIPELCNKVKDFAARMCPKTCAMCCKAKEFNCHDGQSFSFIYNFKESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2K5</accession>
    <name>A0A158Q2K5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4670</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2K5"/>
    <dbReference type="STRING" id="318479.A0A158Q2K5"/>
    <dbReference type="WBParaSite" id="DME_0000031001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000031001-mRNA-1"/>
        <property type="gene ID" value="DME_0000031001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25157at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000031001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57605" checksum="5358400AFFF58AED" modified="2016-06-08" version="1">MISAARSKFSITKLGQLDQPDSSGPSFKEVVKRTRELGSAYKRNDFQKCLYLLKYAKKHSIDENERLKILANTSLCEAKYKGRIYHIEYRNAILVLFPELKSVQDYSLRNATEAVAAFNLALNAFVRGRRKTAIELVRSIMAMENLPDDVFLATSLFAIEMSLTLCQPKLALKQAHRLRENPIWKCSCASQRDYLDILEYRIRCRLAQTVPSLDLARKPQTIHYCLIQSELDMKNGNASKALQRLFKSEESTIPRHCLIYHAALTQLHSGQAGSAFKLFLAVLPFYPRQPRIWLRLAECCIHALQKKRSEKENSIKRIGIGHFVLVSENGLNEHQAELQKNAEISWDFAAQCVRNALVLTEGQNDYMYLLPWLYAASAFINLNLERYGFALRSALHLARLPQVSPLHKFMAVLFKAEALAHLDRLSEALDCLNLAVPLQSIPRTVSALLYNRACLQALAGDLKFSHTLFEQKTDHLLPEAYSLIAYVNLSLGHYSEAKDVAEKMSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2W8</accession>
    <name>A0A158Q2W8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5349</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2W8"/>
    <dbReference type="STRING" id="318479.A0A158Q2W8"/>
    <dbReference type="WBParaSite" id="DME_0000098901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000098901-mRNA-1"/>
        <property type="gene ID" value="DME_0000098901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000089">
        <property type="entry name" value="Protein CBG13067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="54"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000098901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="614" mass="67213" checksum="CABD3F895AA48E9B" modified="2016-06-08" version="1">MGESRQQIKQVDVEPEDSIFSSEQRYKDEIPWWRRNFLFTKPVLFGTWDGVFTTVMVNIFGVIVFLRMGWIVGTAGIAGAILLLIICTILSLIVVFSAIGICERCQIQSGGIYFLVSHVLGGQIGGAIGLIYAFGQSVATGLVAIGFGESVARLLGTDNEKVDKFFATAVLVLLAAINTAGVRWVVRLQLILLAFLILAALDFFLGAIFTTDERNGVGHFSIIQFDLNTDPMYDGTNCSRLGFEVPHQQQSFFTVFGVFFANFLGVLAGVNMSGDLKDPQRSIPTGELAAVFISSAVCFLFIIVLGSMVDRDYLLCDSMISEKVSLTGFLFLTGLYVSSLSSTIGSMLGTPRVIQSIASEGIIPILNPLSVGQGPNKNPVRAGIVMMCIAIVFVLIGDLNKLAILSTMPFMITYAFVNYSYASLAMSYDLQSVNSIDNKLKDNKQSYGSMGEIKEVVETGAADLGGLFPGRAQEFGDYSHSSIIDQPTSWYSMLSNRYISFAGALINLLILLFINVWYALFHFVAVAALYIYIGKVCPSVFPGISQFSLPHMFKTAFSSVESLAPPSLSNIVVTFGDKRNPLTETSTAMLNEENPDFSDRKRYHHSERTQHDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3D9</accession>
    <name>A0A158Q3D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6576</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3D9"/>
    <dbReference type="STRING" id="318479.A0A158Q3D9"/>
    <dbReference type="WBParaSite" id="DME_0000221601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000221601-mRNA-1"/>
        <property type="gene ID" value="DME_0000221601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000221601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35448" checksum="25CA3234BECCE41F" modified="2016-06-08" version="1">MSYFMISRDSNLIFVIIYFDGFRDESRSLANLVSTWFANARRRLKKENKMTWAPPNRPGDDDDDVDDDNDDDFADIDAVEADQCERPSSSGSENVTDNYEVKKEKLETSSSPQDSSQTAQQKCQIKSSMHETFHSTSPQKTSASNKDANNDVLSKKNKIWSIAETISNDSSSSNKKDQPTSSSSNPKLDENSASHQSNSIQLMGGSFNFPANSPFLNLNQWHQQMSLAMHRLPSNYHRPDLFSMMAQTAPLRPVPPPPPPSHLLYNPILIKSVLPPQQPLQTTATSMSNGKWYDPASSPVLNTNDGNNLKKGADSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q439</accession>
    <name>A0A158Q439_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS7932</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q439"/>
    <dbReference type="STRING" id="318479.A0A158Q439"/>
    <dbReference type="WBParaSite" id="DME_0000392701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000392701-mRNA-1"/>
        <property type="gene ID" value="DME_0000392701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="244"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN57959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000392701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48583" checksum="0BADBD279C6D403B" modified="2016-06-08" version="1">MKEEDFEDWKANIKRPEKDMRYKTADVTLTKGIDFEEFCLKRPLLMAIFEKGWEKPSPIQESAISVALSGKDILARAKNGTGKTGAYCIPCIEKINPDLKQIQALIIVPTRELALQTSQICVELSKHLDLKIMVTTGGTDLRDDIMRLNGSVHIIVATPGRILDLMDKGVANMSYCSTLVLDEADKLLSHDFQRVLDKAIPFLPEDRQIMLFSATFPITVTKFMEKHMREPHEINLMDELTLIGVTQYYAYVQEKQKVHCLNTLFRKLQINQSIIFCNSTQRVELLAKKITEIGYSCYYIHSRMAQAHRNRVFHDFRQGNCRNLVCSDLLTRGIDIQAVNVVINFDFPRNSETYLHRIGRSGRFGHLGLAINLITYDDRHALRRIESELKTRISPIPKAVDPKLYVADCHLVDENSEQGRTSVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q483</accession>
    <name>A0A158Q483_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8099</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q483"/>
    <dbReference type="STRING" id="318479.A0A158Q483"/>
    <dbReference type="WBParaSite" id="DME_0000421601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000421601-mRNA-1"/>
        <property type="gene ID" value="DME_0000421601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000421601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47756" checksum="FA5FDE327ABC3343" modified="2016-06-08" version="1">MAAGRLPACIIDNGTGYTKLGYAGNNEPLFIIPSAIAIKEKIGSQSSALRWNTPGSGRIDDLDFFIGDEAFSPNAANYSVKYPIRHGIVEDWDLMERFWEQCIFKYLRAEPEDHYFLLTEPPLNTPENREFTAEIMFESFNIPGLYIAVQAVLALAASWKKRDVSNRPLTGLVVDSGDGVTHCIPVAEGYVIGSCIKHIPIAGRDITYFIQQILREREPTISADQSYEVAKAIKEKYCYVCPDILREFTKYDADISKWVKTYQGINNITEKPFTVDVGYERFLGPEIFFHPEFANAEFTESISETVDAVIQQCPIDVRRGLYENIVLSGGSTMFKDFGRRMQRDIKRISDARLALSEELSKGNLKPKPIDVQVISHKMQRYAVYFGGSLLGSTPEFYQVAHTKAEYMEKGASICRHNPVFGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4B6</accession>
    <name>A0A158Q4B6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8376</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4B6"/>
    <dbReference type="STRING" id="318479.A0A158Q4B6"/>
    <dbReference type="WBParaSite" id="DME_0000449301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000449301-mRNA-1"/>
        <property type="gene ID" value="DME_0000449301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="226"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000449301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52839" checksum="512C701EF68B6D7E" modified="2016-06-08" version="1">MESGDIRDSQISASSSFDAISVGPQNARFASPYLFSGAWCPFQQIRDGAYEFLQVLHIITDVETQGRFAGGAGKEFATHYMIDYLRTGSQWMRYKYRNSSHLIEANKDVSTAIRHTLDPPIIASRIRLVPYSYYPRTVCLRTELYGCQYKGISSLDQNIYQYYKLKRVHNNSWEHQSIGFYANLDGSVELTFEFDEIRQFSYVELWTYKNSLKKTEITFSTNGKQFSLSSQISSIQRKSTNETELRRLPIRIPLHGRRAIAIRMILNFTDSWLFLSEISFSSSKLVIFLSNLKIFEDFMKKSYESKSKPPSWSNFHFPPPPSGKLFIYIKNNYLDIVRFINEIVGGMEYLEQEQLIHGHLSPQCILVDLNLRIKIASPRGVSHHAQLRYSAPESIIMVNSFNEWSCKGDVWSFAITVWELLGYCKEYPFGALSNKELLDNARQYFEDRFQLIICTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4M7</accession>
    <name>A0A158Q4M7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9024</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4M7"/>
    <dbReference type="STRING" id="318479.A0A158Q4M7"/>
    <dbReference type="WBParaSite" id="DME_0000522501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000522501-mRNA-1"/>
        <property type="gene ID" value="DME_0000522501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000522501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52539" checksum="A7080B2747B4E452" modified="2016-06-08" version="1">MSRISLELSEAKLCFVNEFRGKPEESYFYLRSNTIKSYHRKTNDVWITQLINFFNVNACDIAGYERPQIIVDLHLNLASSVFVYEHIGNNEDSTPSFRLFLILLYCSGAPILSMNTITIHNIEIRDLLAASDFKMMLHMCESAKLRRMNAPMFALRILENNDKEGKLAISMLPMRLNVDQDTLEFLQDFFTDLSASSSVSKFTFSPSVPLRLDYQGKRVKSDQGVLMGLLIGLTSLKCSELTLVDFKNTEGLNGIPNCIQFAVNHWIKDIQENQIPNVIGGFGPIRSLVQLGKGIKDLLFLPMNEYRRTDGHLMTGLRRGAESFGSSTITASVEIAQCFTGLVQGAAEIAFDVITPDASVRRKRLDKRKVSDSNLPPNDIRDGLNRAYATVKQGIAETAEGLHKAAYEDRAEGHWPLRGLLRQATPTFLRPIVIASKATNELLGGIKSQWKPEDYAEEIQKWKGNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5A3</accession>
    <name>A0A158Q5A3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1508</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5A3"/>
    <dbReference type="STRING" id="318479.A0A158Q5A3"/>
    <dbReference type="WBParaSite" id="DME_0000689401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000689401-mRNA-1"/>
        <property type="gene ID" value="DME_0000689401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF48">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="145"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000689401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29638" checksum="BD5FD6E57F3078D2" modified="2016-06-08" version="1">MDGWDGWNGSIDCCEGFIKLNEREIKVKIWGFLPYDFSTYQMPHAAHASLISPLINPFMPSNILNLLQDDAKNEKNSNLRPFQIYDPSDPVTALSIPAESSSHKPEQSPTTQVTSSTSDADIQSVQRNVIVRNDNARKKKELVKDDAYWERRRKNNDAAKRSRDSRRQKEDEMAVRAAVLEQENIRLRLELEHLRAETDRLRVLVLSPTILPASSSIISTSTPVIHHPQTLSVISPLHSRSPRNEQFLLQLSTIASSSDSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5S3</accession>
    <name>A0A158Q5S3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10240</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001208">
        <property type="protein sequence ID" value="VDN60267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5S3"/>
    <dbReference type="STRING" id="318479.A0A158Q5S3"/>
    <dbReference type="WBParaSite" id="DME_0000810401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000810401-mRNA-1"/>
        <property type="gene ID" value="DME_0000810401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000810401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37118" checksum="8CFB711ED6991874" modified="2016-06-08" version="1">MNYSQKCWSERHQILSGSVLEMIIFTLFFPPICIFGIVGNILNLMVLLSSQMKSRANTLLACLALCDIVFLILMIPHSLANFDIFAFNYYFRLYYLSARIHLITLANWTSAVAIWFTVCVERVMGIKYPFRTRSHWSRTIIALIIFLILLIAGILTFYNHFSHVCIIREFCNRTQVMAKCFDVTLDKFAFYIVKFVIRKELFVILIRKKTTHQRIEHRLAITVCAIVTCFTITQGPSAIVLSINSFSSKRTPHGHPEMGLNWYHLHTITSFLVIVGKALNFILFCFSSIHFRRQLIGILRAKLKGYTHKQASDISCRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6M4</accession>
    <name>A0A158Q6M4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3942</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000226">
        <property type="protein sequence ID" value="VDN53969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6M4"/>
    <dbReference type="STRING" id="318479.A0A158Q6M4"/>
    <dbReference type="WBParaSite" id="DME_0001048801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001048801-mRNA-1"/>
        <property type="gene ID" value="DME_0001048801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2120021at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14782">
        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="9">
        <location>
            <begin position="144"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="8">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="10">
        <location>
            <begin position="416"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="11">
        <location>
            <begin position="514"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001048801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="72799" checksum="C522D7D257C8A33F" modified="2016-06-08" version="1">MILKALDSFDVSHQIIAKCAHSGIIDESAKSQFIFATTTNKIMVHESDTSLNINDRIQALVIAPLDTSYDVIIVGTTSCILAYDFQRNSSLFQRDIVDGINCIKVGSFSLYDSIIMCGGNCAIWGLDKGGNDLFWTVTGDNVLSLCFCDVDNDGINELIVGSEDFDIRIFKSDLLLYELNETDAVIYLQDLKHERFAYALANGTIGVYKEETRLWRIKSKNQCMAFTVFPDSESLVCAWVFGKIDIRNVENGDITAKESFKGKVANIYTVNNKLVVAMQDGNVRTFEMADSEIGVIADQTILHELGLKKNSLLIELSNYEQCHNDQNDLESKETTVEIEKRIPANTHLETYLTVNWDLVPPSVELQISLSNEAIVRAVIIFAEGIFGGESFTVTQLHIFELTRTLPRFAMFAVCVEDAPEPEGIAEFIINEKPIRLASWINENFLLHDEITSDPDSALAVKFYSLRTKELLFITMDCSGKVVIRNNDMELVGNVVQSIAEYFSLEALSTKANFPFEMKNILEICEKFREAQLIRDRLNADVAEKTGFIKEMIVRAEDARIIGQKGMMKRYYIRLNMLEEEVISGHRIRCNNYNELLKTLRDLNKFIEKAARLRAGAPASRVVAALRNAIAHENFDMMHKIIFYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PT74</accession>
    <name>A0A3P7PT74_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PT74"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="171" mass="19401" checksum="019BBD581BBE0D88" modified="2019-02-13" version="1">MNYNKQFSTSTLSSNSTNTANNSSTIESTKPTEAPITYILRLCRKIECPMGMVQKVRKRILHWCSYMCECAKGLEMKGLKCQKPITTTELMTTVPKIMVYVQRSCGANMIYIERCDFHPISGHMRKCQKISNCVCDVQLYFASDGLCLKIPKTTKNPARLAKKVKMAVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUF1</accession>
    <name>A0A3P7PUF1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUF1"/>
    <dbReference type="STRING" id="318479.A0A3P7PUF1"/>
    <dbReference type="OrthoDB" id="10265743at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057451">
        <property type="entry name" value="BRWD/PHIP_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25313">
        <property type="entry name" value="BRWD_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="948"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="1195" mass="136953" checksum="A2A5467FE9489F55" modified="2019-02-13" version="1">MKRKPLMYDAVAINSAVSVDSVKLLAARELLGRRNSMESLELHCRICGHLSSIFCVTFDRTGLFVITGADDHLVKVWSVMTGLLRFTLRGHSSEISDMSVSHDNTLLATGSVDKSVRIWNLQTAATITVFYAHSATVTLVFFSPFISGNRRYLVSTGGDCVVNFFAYNAENHLFDVSPVSFNERMSQGARIISSSHSVGGNFVVMGDTHRFVRIYKMASDGIEKCFEIEAHKDRVDSLVWAHSGLQFASGSRDGTARVWKFSCNEWESLVLSIDDTKKNANGRGSYRVIMLCWSLEDDMIITSGTDHILHLWCPKTGASKGLLIGHKDDAYVLFSHPVYREYIISAGHDGFLIVWNIYKENIVRKHQNMIEGIGYGAFFDCAISPDGTIIAAVDAQGHLSVYGVGTNQLAKTTPKEQFYHTDYMTLIMDEDGFCLDEELGLPPHLMPPPIFVNADGNPYPALYQRLVPGRDILIDSSLNEVLESAWMSRMMVQSLPVSTITIEIERLKQLQEWECRNIEKECARKKPSVGLRMERSPQYLNRDAPVRRRNSASRRISVAQQASLQQTNVTETYETNAEIAAEEVEIDEIISSSSSEDYTYSSVSPRDEHSASSTTSSEADLSEDDDSFADDSDYHEPSSRSLNRPKRKGHKTNIPEFTETRRRSSRKRRNVVVIEDDNDEIQLDILNSDQPQSSNQDFNRIAIPMNDACIGKVRRKVQGEMVQFPEWMRIVKPCRFPYIAQIGDKVVYFRQGNTAVEMLQLYPVTQRMRPLAELNAEEFCDVVEVKYSRKPYRLTALKLHRLEENGTQTGFVFSVKFHDMDNVPDFIILRSLYDRSVSHRYHPGSRIETILDNHWWTGTIDKKEAEDEENYPRSNWYCIIVKWDTGEDERMSPWDVDPQQPGRRSGIATEKDLIAFAQQPVSDIEWPDNPRGFDGYLERFLEAVRELERKPELRPFISPVNLSKYPEYIRNVDYPVDVDTIMMRMVNRFYRRLLSLEQDIRYIAINANIFNEPGSEIVHNARVLVECLIRYLKFQFIGLINKFYRNTEYSDVQELFDELKNGPITELKEFNHHINKELSVQSKGGRINRQRKNSLGSASSNSSLQWFNDCERIMRNLVSLDRASHFVWDENDQNKETLRSLCDDGCIDLKKMLEKIISMIYTSPLELVADFKHLMETYRNVLDDKRSTVSHLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q5T9</accession>
    <name>A0A3P7Q5T9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q5T9"/>
    <dbReference type="STRING" id="318479.A0A3P7Q5T9"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="8">
        <location>
            <begin position="373"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="64163" checksum="E2060919DE8BA827" modified="2019-02-13" version="1">MYEGEESAGFEKEKKDSNESKSSRRFQVCFQYILLCVEINFVFNSLYNRIGHYSLIIIFSFICEYIGEIIPMREFLKYRSFLHHRRMKNYAVKLSSEFVVDASSRGNISRFINHSCKPNCEIQSINGILRIGIFALRSIKKEEELSYRYSYDFEYFSKCLCNSSKCCGFIGDSASLTAKEIELIRKKKLLLLRNLRSCVGNHQTLPKLGIFYTFFIYCISIFIEILKCVGSYDPDIIDYSICANEESDCVRCICGTPDDDGQMVQCGKCYFWLHGECIPNFNSDEYICEICSQRPLRTPTVEILLRTKLELELKRCIYYRTLVNNRNIQVRINEAVYVQRPVNDNHKTELRILEAAKNSYTDDIEYSCVHTSNQPPAFDSIFQKAAFNRKNLMCFRVERLLLTPSGSKLVFGFYYARPHEVYCEPSKMFHEKEVFLFATTLFDTLPLDCVVGRCLILDSTMYCAGRPRVPRYHESDVFFCDTGYNTKISKFEKLLPKYHYTISTDPLIFERFPEKLQIARSFSNHYYSKLERLVIMKRLKYQNLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q8L7</accession>
    <name>A0A3P7Q8L7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">guanylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10136</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001203">
        <property type="protein sequence ID" value="VDN60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q8L7"/>
    <dbReference type="STRING" id="318479.A0A3P7Q8L7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF355">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="284"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="465" mass="53310" checksum="A46D025D6318BBF0" modified="2019-02-13" version="1">MTENQTNKRRAVETYALLGASKGEFICLKQCKRISWSKERAKMLCELKSLNHENLTNFLGICHNETDRFYTIYTLVERASLEDFIFDQDFNMDATFKSAFIKDIIKGLLYLHKSPIGYHGMLSLKTCLIDSNWVLKMTCFGISTLFYELIKDEYLKTMEIISHKYYINIAPELLEGVQIGRMYPPGTPSGDIYSFGMALFSIIYRCEPFEKTRLAMKGNLVDQMIKMNEKYAQNLERIVAERTSLLIEAQEQTDRLLCEMLPPTIAAQLKSGLPVIPRNYDSVTVAFCQIVDFSLLMAKCTPDQVISFLNDVFTRFDIIINRHDAYKVETTGETYMVASGVPNENQGRHIFEVAEIALEIRQVYFYFTMHTEWNLRVRIGFHCGPIAAGVIGLRSPRYCLFGDTVNFASRMQSNCQPNQIQMAETTAKILMNSTKYQLTKRGIVHVKGKGFTQLVITICETQDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q9B2</accession>
    <name>A0A3P7Q9B2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 9"/>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q9B2"/>
    <dbReference type="STRING" id="318479.A0A3P7Q9B2"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="873" mass="101645" checksum="7CACFD4B06AADEA7" modified="2019-02-13" version="1">MSLNISEFLFISIFYSLKGEIKAKFLEQLSIESHHYLRVKNSVRRSKKISAEKLVKHWNWHQAIFDTLEKNIANLKTISPNEIAELMLNSILSMCGQGQDLVPYYSFELEISDPIFETIHKKFVNKFVDNIDQELFDEYIRYFFEADISRCFTLREWWLRCSSVARVNPEFRIPFTDFSVESRRELGSFLISVMLEACKFPWPNSGLFSCGKMLFAFKLRNVAVEEESLVFDNDRITLTKMIKIEPRLMDIFAEHEFEWLLFPNNLIPMKVPPRPWIEHGYGGPSYTKSTDIIRDMPEYSKVMLNNEMKTRLSSKGQARPVFDALNNLGSTPWKINCRILDVLHKVFDLTFDAKNEGLLRKLSIPLKASAIEVPDYRKIFGLVKVDEIPREEWRKFFGNRCELLKKKNETNSLWFWLKYRLIMAEHYRNEFIFFPHNMDFRGRVYPISPYLSHMGDDLNRSLLLFAEGRALGSRGLSWLKVHCINLCGQKKRSSIEERMDFAEKMLPNMLDSANKPMNGSGWWMESDEPWQTLATCMEIQEAINYHPELYISHLPVHQDGSCNGLQHYAALGRDKQGGSEVNLVPNNVPSDVYTSVAQRIEQKRIEDENSNDTEVKELALALRRALPGPLHRKVIKQTVMTTVYGVTVYGAQVQIKRQLKLFDIPLADVCLFIVFVFCHRFAKYLAQKTFKSLHDAFISSMKLKDWFRQCASEISKLMQPVEWITPLGLPVVQPYLEIGNKNGKLCLLPIKHKQVNAFPPNFIHSLDSTHMMLTSLHCHKLGVTFTAVHDCYWTHAASVELMNSICREQFILLHKQALVTQCAEFFRKKYISQRLRDIMDETDVNYLEEVFTPNIVTGDLDIETIRDSIYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QC84</accession>
    <name>A0A3P7QC84_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytohesin Ubiquitin Protein Inducing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000079">
        <property type="protein sequence ID" value="VDN52797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QC84"/>
    <dbReference type="STRING" id="318479.A0A3P7QC84"/>
    <dbReference type="OrthoDB" id="10063592at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF2">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytohesin Ubiquitin Protein Inducing" evidence="5">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="230" mass="26498" checksum="48A2B39CA3AC5AEF" modified="2019-02-13" version="1">MYQELKKRKNILEEKLLAKLDELREVCIQEAEITGEMPREIYKTLMPGEGEPKVKRRIGTAFSLSDDVLKKNDRISMLETDVELHRKIVAAAERLAKDKSANKSVRKKRQKDLVAATQKLRGLEIGLHQLRLSTSKPDVSETKQTWSNILNRNGSNMVAKSCPATPRGSFPDLSTDNEKCDIDDEKDTDYRQNNNIRPYRFTLILLNALSLLNHFIFLIFCFILFIYILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QF41</accession>
    <name>A0A3P7QF41_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000153">
        <property type="protein sequence ID" value="VDN53617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QF41"/>
    <dbReference type="STRING" id="318479.A0A3P7QF41"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="231"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="8">
        <location>
            <begin position="342"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="632" mass="72380" checksum="C2BD7ED0579992DD" modified="2019-02-13" version="1">MAFKPDGSELLVAADTKIFIYDGNDGTLLQSLKGHKDLVYAVTFSHSGERFASGSADCTVIIWTEQHEGTLKYMHNEAIQCLAFSPVTCTLLSCSINDFGLWTQAEKNISKQRTQSRCTCCAWSHDGQLYAIGMFDGTILLRSALVYFFLFKFSSCFFQKISNFPRSKEQKDVQSGLSSQIRFASHRSYGLNKANLSHLSSKPVQASRYQNQRRNTPEDRFEILIFRLYSSEILAVGDWGQTVAFYDLEGNQVGRDDKKLGYDPTAIDCFNYDQFFIISGSNRQVTLYSREGITLGVIAQMDAWVWTAKSRPFTNAIVVKFISAGCIDGTLACYHLMFSTVHGLHKERYAYRENMTEVIVQHLGRQTSVRLKCNDLVRKVAVYKDRLAIQLNDRVDIYREYADRDDGQLEYKLTDRVNHAFDCSLLVICIKHFILCQESRLQCYDHKGLKQREWLLDSMIRYIKVIGGPPGRETIFIGLRNGAVFKIFVDNPFPIKILQLKSAIRCLDISHLRQYLKLRLETFSASRRKLAVVDEAGICMVFDITTKELLFQEPSCSSVAWNTDYENLLCYSGGGFLSIKVNNFLPYQQRMEGFVVGFSGKRVYCLHLFVMTSMEVPLSNQLYQYLEQKMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QL48</accession>
    <name>A0A3P7QL48_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QL48"/>
    <dbReference type="STRING" id="318479.A0A3P7QL48"/>
    <dbReference type="OrthoDB" id="5847109at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16679" checksum="925DC68CEACD5C88" modified="2019-02-13" version="1">MSGSFAPFVLCMSRTVCVLFDPKEGRKRPAQDVLDRFKRLNSGMWIRCVAGRNKLRYAKNETFQTTSLYYETCTKEQCFMLDRMMTPFWLRPKYYVNDPYEPYHVRHGLTSVRTSNGKLKRERPKILLEDCIADKYFSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QMM8</accession>
    <name>A0A3P7QMM8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional adapter 2-alpha/beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QMM8"/>
    <dbReference type="STRING" id="318479.A0A3P7QMM8"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional adapter 2-alpha/beta-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="150" mass="18200" checksum="572F6410186ECE68" modified="2019-02-13" version="1">MDSCFRYPTSALLTKVKLAKVQRYNRILKQRKVRKGIIREFELKTDEKWSTIAYNQKYNGVMRKNHRLGSLINKAHQVVRRRELMRLLNIITRLQKLPSNEMRKRKRRSIKCNVSYRKANLRWNRFKRWSMRQNTSEIPESEESGSRDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SAM1</accession>
    <name>A0A3P7SAM1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SAM1"/>
    <dbReference type="STRING" id="318479.A0A3P7SAM1"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="195" mass="23412" checksum="D30AB1C6915CCCB1" modified="2019-02-13" version="1">MRLQKRLAADVLKCGKKKVWLDPNEVNEISNANSRQNVRRLIKDGLIIRKPVAVHSRYRARKNLEARRKGRHMGKGKRRGTQNARMPEKILWIRRMRVLRHLLKRYREAKKIDKHLYHELYLRAKGNAFKNKRNLMEYIFKKKTENTRSKQLAEQAEARRIKNKESRKRREERQAVKRAEALRIISESEKDVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SGR2</accession>
    <name>A0A3P7SGR2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000126">
        <property type="protein sequence ID" value="VDN53382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SGR2"/>
    <dbReference type="STRING" id="318479.A0A3P7SGR2"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="70"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="205" mass="22170" checksum="DB5430D2F4F8B62A" modified="2019-02-13" version="1">MVTGAYGAQYSQTSYPDYYGGQMFVSSQEEPATECDYENEPPLLEELGINFLHIREKTLAVLNPVGTVIADQDLAGPLAFCLLFGLALLLHGKVHFGYIYGIGALGCIGMYALLNLMATDKSISFTCTASVLGYCLLPMALLSLIAAVSNFQANWGYLLSGTAVLWCSISSSKLFVVMLALDGQRLLVAYPCILLYCVFALLAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SHA9</accession>
    <name>A0A3P7SHA9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SHA9"/>
    <dbReference type="STRING" id="318479.A0A3P7SHA9"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="333" mass="39680" checksum="83600BDBAFD0CD1D" modified="2019-02-13" version="1">MKFFEKSDIIDIQCNKLLDWLISRRHCNKDWEKGVMDIRRRIGEAVQDMPEDEKVVDLLKGQYIHYFQCLKIIEILKETEKDSKNFLGFYSSQRMNDWLQICQMYEKDNIGLAEASQMLIRLVHYKIPDLKRRIQKCDQNLIICELKEKDYNKLAEEARRQYEKDLQKMGIKGKNINYEISELVMDLPKFFNEIAQEIYSLKDAIDYYDDFSRYLHELINSWLHQVQNLLRKLTDPQKSLLYKIRSSQHHLKMIAESFEHKFSLEERYKNLAQLTVSNQVGIRNARNILEAELNTMVESTRFLQKEIEKEISQKYNGRRVNIMGSVTAALSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M9</accession>
    <name>A0A0N4U0M9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4475</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0M9"/>
    <dbReference type="WBParaSite" id="DME_0000011501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011501-mRNA-1"/>
        <property type="gene ID" value="DME_0000011501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720652" evidence="1">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18757" checksum="6F47D660A311DA06" modified="2015-12-09" version="1">MENSTTIIYLVFFLLVVTFAAQAKADGSDKTALKKIFVAAKNGANKAQIIANINKILKQKMKNLVNSKRKDGVKTHTRHPLQSRKNISYPHSCPPPFLGERKNGKIVKQAPVPRISQKVTSLRNDLRKRIDEIIGGSKTIEKMAIKKIKMPIKIIYKRRGAVGASKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0W1</accession>
    <name>A0A0N4U0W1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dpoe2NT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4567</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0W1"/>
    <dbReference type="WBParaSite" id="DME_0000020701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000020701-mRNA-1"/>
        <property type="gene ID" value="DME_0000020701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000020701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8989" checksum="CE0BABD74D2238D0" modified="2015-12-09" version="1">MGKITETDIILTLIKGFEEVIGSHSSDQIISCLAALAPVSRFEIAAVFLDIRRNEELRQLVPLDNKNQEQAGLIYKIYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U115</accession>
    <name>A0A0N4U115_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">POU domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4626</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U115"/>
    <dbReference type="STRING" id="318479.A0A0N4U115"/>
    <dbReference type="WBParaSite" id="DME_0000026601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000026601-mRNA-1"/>
        <property type="gene ID" value="DME_0000026601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF137">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific" evidence="8">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000026601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23983" checksum="182373F498BBE565" modified="2015-12-09" version="1">MDHTSCAAIRQAVSEITREECIELDELEAFAEEFKRKRRRLGLTQRDVGLGLGHRFGVDFSHSTISRFETLNLSFSNMGKLKSLLSEWLAYAEAAIENGTTVCDLLEAAPSHSQNQPLPNIFGSSNSGTNEAYCTAEMSESRRSLRKRRKRTILDVSQRVPLALYFKLNPRPDHYKIAKLAEILELERDVVRVWFYNRRQKVCRNSKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U138</accession>
    <name>A0A0N4U138_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CWF19-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4653</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U138"/>
    <dbReference type="STRING" id="318479.A0A0N4U138"/>
    <dbReference type="WBParaSite" id="DME_0000029301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000029301-mRNA-1"/>
        <property type="gene ID" value="DME_0000029301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="417"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000029301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58671" checksum="C784672244671649" modified="2015-12-09" version="1">MDQFFYRCLRGKSHQMLGNYITNGPFEFFLCVGEFFGVDEKINSKVMNGDIEFPITTYILVLGPCSPSTSTCYPEGRTEFSPNLIYLGKRGILNTISGLQIGYLSGIESEKASDFEFDKNSVDELLAPVKVGSFTGIDILLTSMWPAQVAKYSPNQPSVEISGSPLISRLASGLKPRYHFAGMGAHYERTPYRNHRVLMELAQHVTRFIGLAPVNNPEKHKWLYAFSITPMRNMSRVNLAAQPSNTSEFPYMELISQMAIHDQIINKQKRHQHQYFFDMSDQQHEVSPYKKRRKKNGRLQDIEQFDPQSCWFCLSNPSFQKHLVVSVSTHSYIAMPKDHIQSIVASSNELREDIQKFKDSLTLMFNKKNMVPVFFERNFKTQHLQINVVPVPKSCSKALRISFINSSNLKNLNMVFLKKDQQIWDMVNEGCPYFYLELPDGTRMFSLKMQNFSLQYAREVLAERQLLNCEEKVNWRSCELNKRQEEELVADLKKSFKPYDFTDDDDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2I0</accession>
    <name>A0A0N4U2I0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5246</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2I0"/>
    <dbReference type="STRING" id="318479.A0A0N4U2I0"/>
    <dbReference type="WBParaSite" id="DME_0000088601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000088601-mRNA-1"/>
        <property type="gene ID" value="DME_0000088601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008092">
        <property type="entry name" value="Ribosomal_mS29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01716">
        <property type="entry name" value="DEATHASSOCP3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000088601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41773" checksum="33CF2B0BF8045BC5" modified="2015-12-09" version="1">MLFFSIDAQYFQAFLSVQDLGHLYEVPMKDVEELNYRKVLPSPYKKQIETLNECLWMYRESLWDVITCLQAVRPTFPSLRIVLWGKFGTGKTITLHQAVHYAFTQNWVIFVVPDAMRITRCTLDIQMSSHHVGRVDCPALGKELLENFKLNNAHLWEKLSELVTEKDYVWSRIDKTESGRPITDIVDMGISMPYAASDCVGALLKELKRYSSSGKIRFLVAIDAANSLFGRTTVRRSDRKFVNTADLTLVHCMKKLLSNDWTNGCCIMVADKKEFSNPRDEETVPLITPLELFGEEGIDSIEPFIPIETKLYTVAEANSIYEYYKSKRWIVTEKGRSERGKKELIYLSAFSPFYLERMCAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2M7</accession>
    <name>A0A0N4U2M7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5305</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2M7"/>
    <dbReference type="WBParaSite" id="DME_0000094501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000094501-mRNA-1"/>
        <property type="gene ID" value="DME_0000094501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Cuticlin N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000094501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20942" checksum="DBD7F3B28F3B2A6E" modified="2015-12-09" version="1">MAEYSKIYKHLAIKMIVGEAKVECERDFIRFSVPTLMPFKGKVFVKGEYINSQCVKNYALKGQAGEKVGAEENEHNETARKEVNQTIDRGNQSLRINENELGIAIERPNKTKAKFVNNPMEGTLATNSYCPPCPICSTENAKRYERQAEETNEASITIKSDTCNAKRDRIVIILAFLIIFYLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2M8</accession>
    <name>A0A0N4U2M8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5306</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2M8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2M8"/>
    <dbReference type="WBParaSite" id="DME_0000094601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000094601-mRNA-1"/>
        <property type="gene ID" value="DME_0000094601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000094601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="525" mass="56935" checksum="F595CAF1F08B6610" modified="2015-12-09" version="1">MAASAIANIMKSSLGPVGLDKMLVDEVGEALITNDGATILKHLDVQHPAAKVLVELAQLQDEEVGDGTSSVVIIAAEMLKAADELVKHKLHPTTVINGYRLACKEAVRYMQENLSISVQELGRQSVLGSAKTAMASKVIGTDADFFAEMVLEAVDLIKTTDAKGHVKYPIKAINILKAHGKSIRESMLIRGYALNSTIASQAMPRVIRNAKIACLDFSLQKIKMHLGISVVVEDPEKLEAFRREEAAITKRRIEKILKAGANVILTTGGIDDFCLKQFVEADAMAVRRCKKADLKRIAKAVGATLTASLVNLDGNETFEPSLLGSADEVIQERISDDELILIKGTKGRTASSIILRGPNDVMLDEIERSIHDALCVVQRVLESKKLVVGGGAVEAALNVYLEAFSTTLSSREQLSVAEFANALLVIPKTLASNAAKDSTELVARLRAFHNKAQQVKDLAHLKWAGLDLENGEVRDNKAAGVLEPLMSKVKSLKFATEAAITILRIDDLIKLEKPPEKPRDEDQCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3S8</accession>
    <name>A0A0N4U3S8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5750</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-like protein involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3S8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3S8"/>
    <dbReference type="WBParaSite" id="DME_0000139001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000139001-mRNA-1"/>
        <property type="gene ID" value="DME_0000139001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1 4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000139001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11040" checksum="D132FD549E923D66" modified="2015-12-09" version="1">MEQEKKNKVEILFKAVGDAPIMKQPKWSVDEDKTIAWLASFIRQYLKLNSTENLFFFINQTFAPSLDQTVSNLKECYAVGESRLVMHYSLVYAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U442</accession>
    <name>A0A0N4U442_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF1279 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5893</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U442"/>
    <dbReference type="WBParaSite" id="DME_0000153301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000153301-mRNA-1"/>
        <property type="gene ID" value="DME_0000153301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874039at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF1">
        <property type="entry name" value="PROTEIN FAM210A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="7">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000153301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18996" checksum="99CAE7A2BF1A1EE3" modified="2015-12-09" version="1">EEKPRTILQKIRYYFKRYWYIAIPVHTVSCILWFAIAYLIVRSGIDIVAMLEYFNVPEILVEKVKKTPPSAGTALVAFILYKIATPLRYITTIVGIQLAFYILRRFGWLRTAKEFEYKIRSEYEKKGLHKVGRHYRGYGRLGRRTLRKIFKNVIFYDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U479</accession>
    <name>A0A0N4U479_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U479"/>
    <dbReference type="WBParaSite" id="DME_0000157501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000157501-mRNA-1"/>
        <property type="gene ID" value="DME_0000157501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000157501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7363" checksum="3F84FD99452B3F73" modified="2015-12-09" version="1">MPKAYISSNKEFKLFGKAKKTFSIAALDPDANLPITEFIVTASLSTRVFQSIPIITMSCFGRDFISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U489</accession>
    <name>A0A0N4U489_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyco_hydro_35 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5946</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U489"/>
    <dbReference type="STRING" id="318479.A0A0N4U489"/>
    <dbReference type="WBParaSite" id="DME_0000158601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000158601-mRNA-1"/>
        <property type="gene ID" value="DME_0000158601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="2">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000158601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13361" checksum="CF643D26816E6D69" modified="2015-12-09" version="1">MRIAHFKMVSSISNGKKAIQILGKRENRNMAGFKMRQGGTTQYISASIHYFRIHPDYWEDRLKRIRAAGLNAIQTYVPWNFHEPEKGKYLLSGWRNITLFFDIAAQQGLYILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4B0</accession>
    <name>A0A0N4U4B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5969</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4B0"/>
    <dbReference type="STRING" id="318479.A0A0N4U4B0"/>
    <dbReference type="WBParaSite" id="DME_0000160901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000160901-mRNA-1"/>
        <property type="gene ID" value="DME_0000160901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000160901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8978" checksum="8D1A0AC93F035B8D" modified="2015-12-09" version="1">MSIGHINIRERKLEDAVFEGWLLKRGEHIKNWRRRYFMLYDDGALFGFKTKPELGQPFPDPLNDFIVKGVQVNESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4V6</accession>
    <name>A0A0N4U4V6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6202</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4V6"/>
    <dbReference type="STRING" id="318479.A0A0N4U4V6"/>
    <dbReference type="WBParaSite" id="DME_0000184201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000184201-mRNA-1"/>
        <property type="gene ID" value="DME_0000184201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000184201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10345" checksum="80B86DFB8960840D" modified="2015-12-09" version="1">MENIETLGSLRERLNGTSLVEDNISFGGCQMSYRLQSRGGIAANIRRIAEKQEEHLKERRQLRRETREITKTLKRLPVRGSFSSRGGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P5</accession>
    <name>A0A0N4U5P5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase RBBP6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6541</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P5"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P5"/>
    <dbReference type="WBParaSite" id="DME_0000218101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000218101-mRNA-1"/>
        <property type="gene ID" value="DME_0000218101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="DWNN" evidence="11">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="938"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1241"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000218101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1485" mass="170003" checksum="1A749BA260CE854A" modified="2016-06-08" version="2">MSSIHYKFKATLEYKTLSFDGLHISVNELKREICEKENIKVSYLWNLFVSFFFERSLADSFDLILTNAHTKRQYVAEELIPRNSSVIVQRTPRDNASKLPKIHYSEFHKAIDIRKLCEYSLICRDTANSGIVVKPVAEPNFVTHIDSVKKCFKFQDQYEKMTENERLAHVKEVSSYKYSPANFQKKTSSIMSGPPPPTYICNRCSQPGHWYKNCPMVLKISVLLLANCSVRIVRMVVFEDYEPIVIDLNTRRTTGITMEELMETTSDDPLAMLHSSGKYMVPIMHWKARQQKKVESTNNVEQEVRLIPEEFTCFLCKQLLRDAVVTTCCGESFCAECIQQCLLESSNAKCPGAGCYQMSLSADKLVPNIKVRQAVEAFKNAPIGSHNTLQSSASFPNLNDAVKNLSQQEKSAKISENAAINSPRFDEQPSQPSRVRIELGSRSQQPQQPVVQQNIPHIPQEPQPATYIAQPTDSASTVVSVTAVTALSSAVPISAQVSVPVAPLNIPVNTHNSPLASVPHQNTLFPINLSQPPPGYAPMPLNVPGNVDSSIRPPGSRDNTLDVMNSLNHPHFYCAGIQPPPPGLSAPIMFPRVAAPPPAKDAWDEFIERKEKVRFCEKIAHPQRHRRSARSSSSSTSETSSSSSSESSRSRSRSWSRERSRRNRRRSSRERRNRSRSPLRGYISSHHHRDVAPFAYYQHHSQASLGIPVSHHRIPSILSGFQSSQLAYPLPNQLPYPHYGAAVSSAHRSFRNSDERTLKRRSPRYSGSERKLDRVFWFGLSFQASVFIPPVRVGRRTSQNKERVRERKDYYKHEDVKKKKRDNENKSTENRKATRDTKDESRGRLNLEINLDSKGKSIDESDLDGRKSKQESSPRKIAKVNSVDQEKDNDGTGDLEPNFDKVQMAEIVVKDSASNSLLETEIASATPDEVVLEYIHEPDHEINEDNDILKDESQNIDDNHISSMIKAEDEELSSSKTKDREESVDKAERKSRKKKRKKRRKHKRLDKHHEEKRHHSDDGERKSKKHKRSREEKEKRKYEKEKRREERRRRKEKEKLNTKELSEDITIKNLSVNETEENLKSSSVNKEFGGKELDMAHEGFKSEESNEDSKRWKKQSLVEERNEGKNKNEKRTKSDSQRETKVDQKNSEFSVESKNYEGRHGNKREKKEKESGTGDERKIRREMDSRRQEIDSGKEKHIQILDRGNTEKNERDTRKKIESNRSAREKEENMKEKDKKERDIKSSKYRFEFLHTSEPSSFSAKEISKTHRISLAANKVEKKNIDDERNSDKESMKHLRKNPDKNLTENVLDEIPSKIPRLDSMKRKKGDVQRSSTEDDKTINIGRLAESKEIDVSKPGQSAIIKNAICVEKSTVESKSVNTKKINRESVFENSSALSTAMPVKQFNARQKIKMILLSENERFAKSKVYSAFFFACFSIFCVLSVLWIASAVGSKDVWELPGWSNASDLAMTELMDRYCGMARVSCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U693</accession>
    <name>A0A0N4U693_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6785</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U693"/>
    <dbReference type="STRING" id="318479.A0A0N4U693"/>
    <dbReference type="WBParaSite" id="DME_0000242501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000242501-mRNA-1"/>
        <property type="gene ID" value="DME_0000242501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990815at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000046">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="484"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000242501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="597" mass="69098" checksum="845A208C7684D7A8" modified="2015-12-09" version="1">MKTSLLIANGDSDASGTLTNCESDCSQNRTKLTSNQSEDCLIKNSLNYSDSDKSHWNMQKFDVNEFEDEEKFVYKKNLPKSYYIFKEFMMTERTAVFDLKILAQNFQRLFLKHTLMSTRTFSELFSTIQPLYVFHRDLLNDLEIKMKNWENSQIIANGCFGSDHFRTGELFLCSVHNALHYHRDLIQQAPIFLAAIDELNRTNKSFCNSYRSMQDEDYCYLPINCLFLKAVFRMILGRIVAAFLEEGGDSDGTTQLSSSRVALEKIASFNRESKIIRESLVNFVKMVELQSYLTEVEGLIHPKRKFVREGWIFKWTKRGLIPHILILFNDSILFAHRSSSGFSVDGIHDLRGMTITDGDLFHLTSDPTTCITIHAYNQPIILSANSTNSKEIWKEELSNMIEQVKKCKIEQLPKSITTSSFAKSDDTGFYEDFVDSRKNSSTNNVAIEQENVARKKRNSKTNVSQICWYRQSTLMMSSLIKAPINQISGYLLRKLRTSTGWQKLWVVHANFTLFFYKSHQDLSPLAILPLIDYYISLPSLNDEIDRENVFKLSYKTHFYFLATDSFYSLSRWVETIRESTLNANRCDILASLLSYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6P5</accession>
    <name>A0A0N4U6P5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6971</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6P5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6P5"/>
    <dbReference type="WBParaSite" id="DME_0000261101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000261101-mRNA-1"/>
        <property type="gene ID" value="DME_0000261101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000261101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30682" checksum="8176469D366E2D4A" modified="2016-06-08" version="2">MIYPQPNNFINIRSNFTLRHPNIVQLYDTYDEKHCVYLVMELVTGGELFDRIVSKGSFTERDASVLMRQVLEAVAFMHKNGVVHRLDLKPENLLYYNKEEDSKIMISDFGLSKTEDSGTMETACGTPAVDIWSIGVITYILLCGYPPFYDDNDANLFAQIIRGEYEFDSPYWDEISESAKDFISHLMCCDPEKRYTCEQALEHPWISGNTASTKNIHCLVAPQLQQSLIKRKWKKAFNATSAIRQLQMLRLTHSPSTSSDRTQKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6T0</accession>
    <name>A0A0N4U6T0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7009</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6T0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6T0"/>
    <dbReference type="WBParaSite" id="DME_0000264901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000264901-mRNA-1"/>
        <property type="gene ID" value="DME_0000264901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="328"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000264901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48171" checksum="9A76B26713382503" modified="2015-12-09" version="1">MLRRLYQSMLANLPPQNDRVMAEYSGQLINQQYGIDLGHSPAGIQRLSAQHTSPQQQQQLQHQQQPPSHMMSSGPMAISQQQLLMQANQPIHMPTHCGNISVHQMGPAQVVSHQGMSMMNSSGPMQQPDNKLWSPNEFFISVGSQSQMIQAQHQVLPMQSQQQQQSQIVVPAINHPQIMNSLVQQPQQNQSHQIMPSNAAMLQQQSMCQQAQQHSIGRSPGFAHPSQSHIHNSSHCYQQASPNRPSLSRYPTPSPESVAHTPIFSWENLCVIDRAPVQRPAVEMRVIGQSSAIRQALGHLPAVPSTSSISSVNSDHSTLHTNLQLIDKEALEALIKSVDPLETVEDDVSEALLQLIEEFVDDVVDQTARVAKHRSATKLETKDVQYVLARKYKIFLPAQPVNGVVNECIPSKSPLVEAHRQRTNLIKKVLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7R0</accession>
    <name>A0A0N4U7R0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TRAF-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7192</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7R0"/>
    <dbReference type="STRING" id="318479.A0A0N4U7R0"/>
    <dbReference type="WBParaSite" id="DME_0000303301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303301-mRNA-1"/>
        <property type="gene ID" value="DME_0000303301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5574452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00270">
        <property type="entry name" value="MATH_TRAF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000017">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF151">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR (TRAF) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="9">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="174"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47405" checksum="D0A1D8A8A42FF112" modified="2015-12-09" version="1">MYSGTFLQNSPYVAHFCHPKYHVFDCKYADVVCQRGCGQIYIKMNEQKHLNEDCDRRMGKCEFCEKEIALKGMDIHLKVIDHHSGPNPVCPDYIIDCPNNCGLKAVPREKIKQHLPVCVNAGAACPFNEFGCDYMGDTRNTSMLLFNMETIMEMLVCKMDALQRRTATLEKLYGPQTIWRIDNVKQKQNEARSGAKTMIFSPPFITGRHGYKMFLSASLYGDGPIRGQYMSVFVGIMRGEYDALLEWPFTHKVTITLMDQNPDVTNRNDISYIIKPNPLPAYKAYLDRPVSERNASFGAVKFCELEILDRYIRDDVIYIKVNVDTDSEKYEQSSEAFISQMNKKSQTKTLTSNNTVETKNKIKEIQQLLKPANQVPIEINQKPDNNWSDVITDQPKSVNYTHLYNQSSVYNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7T5</accession>
    <name>A0A0N4U7T5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7223</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7T5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7T5"/>
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        <property type="protein sequence ID" value="DME_0000306401-mRNA-1"/>
        <property type="gene ID" value="DME_0000306401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mRNA catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="CNOT9"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000306401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40955" checksum="1A6F541C9C6D24E5" modified="2015-12-09" version="1">MLAKRTRLHSMEELNYSLRCHRPGRLAAAMASSEIREMAQSTEEQQYTDVNQVHQWILDLIDPIKRENALLELRKILNLAIIASDICSKRRNVVPDLAVWLWYTSGSMAALILELITIYPTITTPTLTVRQSNRACNALALMQCVASHRETAIHFLAAHIPLFLFPFLHTTSESRPYEFLRLTSLGEVIQFLLTTDIISLCLQIMNTGTELSKTVATFILQKVLLNDDGLAYVCRKYECFLQVIMVLKKMVIQLAQQQSLRLLKHIIRCYNRLSENPRLILNPFPNSSNFEIFDQIIISLFSATQILRQYIPDQLRDGTFNQILQEDKLTRHWLTQLLKNIGKFHWNILIIQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8V6</accession>
    <name>A0A0N4U8V6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spondin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7499</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8V6"/>
    <dbReference type="WBParaSite" id="DME_0000349401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000349401-mRNA-1"/>
        <property type="gene ID" value="DME_0000349401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041081759" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000349401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7922" checksum="5E0F78F48532B41F" modified="2015-12-09" version="1">MKLSIILLVALLTTFRVNATNSQLFIIKKSPWFMRPAWRPVDIPNARRFYPSNVDTWFKTIEKEDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U960</accession>
    <name>A0A0N4U960_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS7611</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U960"/>
    <dbReference type="SMR" id="A0A0N4U960"/>
    <dbReference type="STRING" id="318479.A0A0N4U960"/>
    <dbReference type="WBParaSite" id="DME_0000360601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000360601-mRNA-1"/>
        <property type="gene ID" value="DME_0000360601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN57638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000360601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15370" checksum="73A8508EA50B5FA9" modified="2015-12-09" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVLALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9J6</accession>
    <name>A0A0N4U9J6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7771</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9J6"/>
    <dbReference type="WBParaSite" id="DME_0000376601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000376601-mRNA-1"/>
        <property type="gene ID" value="DME_0000376601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041159892" evidence="1">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000376601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27472" checksum="12F8E9BE04142CEA" modified="2015-12-09" version="1">MYTAIQLKILFLSLTLFSEPFDTQSPVIHINLRNDRYLYPYAYSGNTALVSSTTPPLANQVLSPHSYYYSPDLYSQSTPHHPLLYTNLMYDPMKNVNYQYLQTNLQEKFYQNNYRGVNNDLQNATNYMLPVVRTNADQNKMNYANILKEYKTGAISKYLRNSINNINGYDYSINPMNQMNTAIRIAQNPYTGAYNNSDGPLHISDHGLVYDATVYWPQRVSNRAAAPDSSSYYQATLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9K5</accession>
    <name>A0A0N4U9K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7781</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9K5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9K5"/>
    <dbReference type="WBParaSite" id="DME_0000377601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000377601-mRNA-1"/>
        <property type="gene ID" value="DME_0000377601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000377601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21381" checksum="7617B8F47F37784A" modified="2015-12-09" version="1">MPCIFLNFFDCAMIIIVVLSFFFNFFRYLKIIEIKCYTTESGKIMLAPSILYGTCLYITLKVSHNTSLVTFHPIRSFSPVLTILLSLYVLRKKLPTRRIMFIILLICLSTSATSIIFISFNLLNFYNAWSYLFGFAVLFMQPTAFVMIEHRSKMIANYVLYINTFNSLGLFLIFDLFEVTFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA17</accession>
    <name>A0A0N4UA17_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL36m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L36, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7969</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA17"/>
    <dbReference type="STRING" id="318479.A0A0N4UA17"/>
    <dbReference type="WBParaSite" id="DME_0000396401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000396401-mRNA-1"/>
        <property type="gene ID" value="DME_0000396401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000396401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9202" checksum="BC9A177BCC99B6E2" modified="2015-12-09" version="1">MLAVGRLMRRAIFQGNNTMDKLLIAKLPSEINSQNFKMKAFLKLRCKDCYFIRVDGRWEVKCSQYPRHHTKQAGVLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA95</accession>
    <name>A0A0N4UA95_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS418</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA95"/>
    <dbReference type="STRING" id="318479.A0A0N4UA95"/>
    <dbReference type="WBParaSite" id="DME_0000405401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000405401-mRNA-1"/>
        <property type="gene ID" value="DME_0000405401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805083at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000405401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1371" mass="157785" checksum="01C42A62CCB6D39F" modified="2016-06-08" version="2">MDSIMAQLQEVEIRENIVGMNFEEDGSSSALAFNNNKKRKLSEVCDEANCFLNRKMKREIDINEEAENIIITNSENEDIRNFLLRDLNAKSNSEWKLIIKERLKFCENLGLKTVAVRRKEEESGEECVGSANVELSQICTEKPPYDQSIDSICKFSSIRRLFISGERRKIIKVLDDYEKFTIASNGFKYFLKLCTDLVFEKISSKLEKKQLNDTGTVESVAKILRFSWNHMARNSRQKWEIEARKRLCFERTDTEESMDLNHDGVINKIIAMKKDKANGKSSENIEQLCRKIDIMPTADEKFRSFLTKKMHEDREKFFDGIIKCPLCRNKEIYIAENDLQDHLINEHYSIHLYACHSCFEAFPSIDLLKKHPCAEFAQYNVHLLTANSKFEFNMVMHTVICGECNLQVPLSGIDRFSTIARLRGLLGLHDSKRLVSCLVFFAENPLGMEYVYLKGFVMENCISVKCSLCNHQYTSAKDIETHQDMHISEITPLICSVCLSSFKSQLFYRNHMLGHLGDTDSFAPLIDTLTQTPPFWFIKEFPEICCDLIHADLLPYYSMDDLDEVTKEDVSFMKSSKKSDIENQISSTKSKSADKKKRRKKCYLCRQLDQFGSGHSGSYLCVCGNSKSCIEFKKCEIDICSFIEQFKREAKIFVGPNASVHDPSKGALLIFSCNSLLNVRIFCPWCNISCCSITSLRRHFIIKHGVYAEFEAPAYLKSIGIMEWNHPLTYLNANAEAININVGLTKDGRFDCVAENELTSQSESDILLTTDSSDSSLLCSQMSPTFSIQEQSKMLTKTTDLDEDALLFKGNRFCPVCFGTFASSHFARHFVPVHLHICKQCGIGFTDSERLKLHSCQEWPHELSDDKFVPHCYLCNSTLADPVKYYYHLIHSHASEFKIDREKQQILPMFIWKKLDLYDVNSISDSEKALDRNMTGKSADKNSEALIKISKTSDVSLNRNKNTVSLNWELLKEQAKLLQVQVYCQLCEKPCQVASFNRHLQTHHKIWKICPVCNFNDELVPVKSIRHLFMHIASKHIRKQYLSITEIGLNCLFCDYMICYSPSDYKKSTQSEEKMTRHILFFCTGFNICLLCNNRKKLNAKDLLNHRSSVHAEIYFRFKCYHCSEKFPIMSLFDAHKCRQNLIKCSCGSRKSYSESQFWKHFGEHLNTSTNFCFLCNQSFHPSELRNHMEVHANYLTSSRVVIDLVDKRIPIIRPKVGLSDVQLANSVLLNISQPHSSSSVNQDLSKETSILMKNKSSISNSNEQESEFILHEKTSSNNDCKENDAQISKTEDNYIINTTEEYAPCSEKSKISISENKNIDKDPEIFDHQPGNNDVEIIQFNEFVSSDIRIENEPKNVLDDDILFVDTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAD5</accession>
    <name>A0A0N4UAD5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Integrin beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS470</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAD5"/>
    <dbReference type="STRING" id="318479.A0A0N4UAD5"/>
    <dbReference type="WBParaSite" id="DME_0000410601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000410601-mRNA-1"/>
        <property type="gene ID" value="DME_0000410601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002164">
        <property type="term" value="P:larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110020">
        <property type="term" value="P:regulation of actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055002">
        <property type="term" value="P:striated muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000098">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000155">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000694">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="19">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit tail" evidence="21">
        <location>
            <begin position="317"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="20">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN50497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="DME_0000410601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52312" checksum="E1FF186EC25D8453" modified="2015-12-09" version="1">MRTSGRRTSDRQSTSLLSDALPDVSSSVGVLADDSRNIVTLIEEEYNKISQKIIMVDNANSTQGLRLSYKSKCLHGYALKETNVCEGIKVGDEVTFEVTLEATHCVKQRDFELKIGPSGLDETLAVDVHVQCDCDCESNVIVFTIEYSPVCHGKGDLVCGVCICRGTNVGRHCECDAPGLSTVALDAKCKRTNESAICEGRGICNCGVCECIQRDNVNEKISGQYCECDNFNCPRHDRKICAGHGTCDCGQCTCEPGWTGRACECPLSLDSCMAANGKVCNGQGECICGRCRCFSDGPGNRYSGPKCEICPTCPSKCVEHKPCVMCQQWQTGPYNETQCADCPFTVIAVKELPVLNETIECQFVDSADDCTFYFLYFHDERTDNLTVWVKEEKDCPPPVPVLAIVLGVIAGIVILGLILLLVWKLLTVLHDRAEFAKFDNERLMAKWDTNENPIYKQATTTFKNPVYIGNSMKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAT5</accession>
    <name>A0A0N4UAT5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8166</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAT5"/>
    <dbReference type="STRING" id="318479.A0A0N4UAT5"/>
    <dbReference type="WBParaSite" id="DME_0000428301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000428301-mRNA-1"/>
        <property type="gene ID" value="DME_0000428301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF31">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="10">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="10">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000428301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28695" checksum="47DBC5FEF55758E4" modified="2015-12-09" version="1">MSDAKSDKFYGVAHGRKPGVYENWSDVQEQIQGFPQPVYKKFHSKNEAETYVKERQPEQTLMDVDESADKFYAVARGKVNGIFTSYEEVKKHIANYPQPMYKKFNNIADAKSYFKKYTKGEDDSGNFSKFFFNISHYFCFEAKSGQKATKAKNEGKKIDDKEKECNSVFYAVARGHKKGVFSTWAECQEQTKDFKGAKFKKFDNEEDAKMFAEGKTLKQIEDRKRKHEKANGDEACEAETAKQQKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAT9</accession>
    <name>A0A0N4UAT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAT9"/>
    <dbReference type="WBParaSite" id="DME_0000428701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000428701-mRNA-1"/>
        <property type="gene ID" value="DME_0000428701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856203at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000428701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14322" checksum="00EC3EBFDED0DBDF" modified="2015-12-09" version="1">MENLYLKDSPLNSVSKIMQKFILNEAYVVNFALYPMPNFADAFIREKFDQLIKELEMIPKYGIGPEGTNLWIREFSDVIIIFHLLDSQIPQIWMSSRFRYRCINYLFIIFDIYRMKVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB30</accession>
    <name>A0A0N4UB30_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8272</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB30"/>
    <dbReference type="WBParaSite" id="DME_0000438901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000438901-mRNA-1"/>
        <property type="gene ID" value="DME_0000438901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000438901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13973" checksum="810C92BA81C731BC" modified="2015-12-09" version="1">MSLKENSEETLSSTTTTVQNFLNYRPFELDLSDDGSIASEPDHEHSSKARRSSTGKQRRSSTASQLSPSISSSLQLGGPLPSYPVSLRKQIAIIKQHLLFHKFIDDIQSRSLFFLKEFMELINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB89</accession>
    <name>A0A0N4UB89_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS8337</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPII-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB89"/>
    <dbReference type="STRING" id="318479.A0A0N4UB89"/>
    <dbReference type="WBParaSite" id="DME_0000445401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000445401-mRNA-1"/>
        <property type="gene ID" value="DME_0000445401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="13">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="14">
        <location>
            <begin position="130"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="16">
        <location>
            <begin position="438"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="15">
        <location>
            <begin position="555"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="12">
        <location>
            <begin position="670"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN58364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000445401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="801" mass="89871" checksum="45679B608C09AF01" modified="2015-12-09" version="1">MATWEEYLINQANIDGIQMTWNLWPHSRIDAQRLVVPIATFFTPLKERSDHYRQPPLEYDPVLCQKSSCKAVLNALCMVDYRNKSWICPFCNQRNPFPPHYNMIAEDNRPPELYPQFTTIEYTLKRASTLPPIFLFVLDTCISNDELKALKESIQTALSLLPVDALVGLITFGRMVELHELSVQGISRAYVFKGSKEVTQKQLRDVLSMNIGKPSFCPTSVDGVGGVAGSQMKSTIPSNRTTPSNANVHVMAPNQISQPQLPFNKFLQPISDCEMSINDLIEGIQPDRWPVSQGHRPLRSTGSALAVAVTLLEVCFPNTGARIMTFIGGPCTHGPGAVVDDELKNPIRSWHSIKEDNVLYMKKATKYYDSLAARAVTNGHVIDIYSCALDQTGLHEMRACFNTTAGNVVMGDSFISSLFKQSYQRVFEKDSSGFLKMGFNATLEVKVGAGLKIEGLIGCCANGQVRNALVSDTEIGLSGTCQWKFCSVNPRTTIAVLFEVTAQHGSTVPQGARGMIQFVTQYQHPDGRKRIRVTTTCRNWADMNLQQSSIAYGFDQEAAAVIMARLASWRAMNENDTPDALRWVDRSLIRLCQKFGEYHKDDPLSFRLSDKFSLFPQFMFHLRRSQFLQVFNNSPDETAYYRHILLSENVLESTTMIQPVLFSYSFNGPPEPVLLDTSSILPDRILLMDDYFHVLIFHGQTIATWRKMNYQDDPQYGAFKQLLEAPIADAAGILQERFPVPRYIITEHEGSQARFLLSKVNPSLTHNNPYASEGGAPVFTDDVSLQVFMEHLKKLAVSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBT0</accession>
    <name>A0A0N4UBT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab-6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8566</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBT0"/>
    <dbReference type="WBParaSite" id="DME_0000468301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000468301-mRNA-1"/>
        <property type="gene ID" value="DME_0000468301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000139">
        <property type="entry name" value="ras-related protein Rab-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000468301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24943" checksum="B2D824D05615380D" modified="2015-12-09" version="1">MASDFGNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNANSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSTEEGERKAKELNVMFIETSAKAGYNVKQLFRRIAGALPGIEPDQKDKHDSKCKMVHVILFTDPVIEIGPIKPRKIETEEGSCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC07</accession>
    <name>A0A0N4UC07_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8654</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC07"/>
    <dbReference type="WBParaSite" id="DME_0000477101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000477101-mRNA-1"/>
        <property type="gene ID" value="DME_0000477101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5787496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000477101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16286" checksum="A8301122F76F2D62" modified="2015-12-09" version="1">MIWVNFPFQIFFYKIFLERNRCGDIVVDKKRIAFYICPTKKHTSLENRCCDAPEYNCCREATFYENNKLAILSTISIIAFTIFTIVIVICLCWEKCFLHKIVRRKPQLDYIGNIFLKKFCLTKPDEVEHLNGIYVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC26</accession>
    <name>A0A0N4UC26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8678</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC26"/>
    <dbReference type="STRING" id="318479.A0A0N4UC26"/>
    <dbReference type="WBParaSite" id="DME_0000479501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000479501-mRNA-1"/>
        <property type="gene ID" value="DME_0000479501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000479501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21981" checksum="0CB24A68B71B4270" modified="2015-12-09" version="1">MPIKSRIDLKKQEAERLHALVVELLREDENKYCADCEAKQPRWASWNLGVFLCIRCAGIHRNLGVHLTKIKSVNLDSWTAEQVQSMRVMGNKRAKQVYEAELPEHFRRPQTDQALESFIRAKYEHKRYIIFFSSFLNNANSPGSIAPQIMPPENVIDSTVSQHNNVANLLDFDNEPVPVAALGKEHNLVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDC3</accession>
    <name>A0A0N4UDC3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9121</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDC3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDC3"/>
    <dbReference type="WBParaSite" id="DME_0000532201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000532201-mRNA-1"/>
        <property type="gene ID" value="DME_0000532201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000532201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="57605" checksum="4D72105EDEC12C04" modified="2015-12-09" version="1">MPGNLLAMGIQHIRFQSTITHTIKVQEKIKEMRVKAKLGGGEKRIDSQHKRGKLTARERVHLLLDPGSFKEYDMFVEHRCQDFGMENEKYPGDSVVTGRGTISGRTTFVFSQDFTVFGGSLSSVHAEKICKIMKAALEVGAPVIGLNDSGGARIQEGVDSLAGYAHIFQANVMSSGVIPQISLIMGPCAGGAVYSPALTDFTFMVRDTSYLFITGPDVVKAVTNEEVTQEELGGSKTHTVTSGVAHGAFDNDVDALLNIRELFNYLPLSNRDPAPVRACEDPWDRDVPSLETVVPLESTAAYNMLDVIHALVDEGDFFEIMPDYAKNIVVGFARMNGRTIGVVGNNPKYAAGCLDINSSVKGARFVRFCDAFNIPLVTLVDVPGFLPGTAQEYGGIIRHGAKLIYAYAEATVPKITVITRKAFGGAYDVMSSKHLRGDINYAWPTAEVAVMGAKGAVSILYRGDKTNVQKHEEDYINLFSNPFPAAVRGFVDDIIDPHTTRKRICLDLNLLESKKLTNPSKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDE5</accession>
    <name>A0A0N4UDE5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pseudouridylate synthase 1 homolog</fullName>
            <ecNumber evidence="12">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA pseudouridine synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS9150</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Forms a complex with RARG and the SRA1 RNA in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UDE5"/>
    <dbReference type="WBParaSite" id="DME_0000535101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000535101-mRNA-1"/>
        <property type="gene ID" value="DME_0000535101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="20">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN59177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000535101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42518" checksum="345F2CD47284B538" modified="2015-12-09" version="1">MIRLISEKPISKKSAKRIRYAILLAYRGQNYFGMQLQKEYPTVEGCLLKALLENNFISKEEYKDPFLCYFQRASRTDRSVSAVRQVCTIKMPKNNNFITNGSDILNMKLPLDIRIFGIRRTTPSFHPQKSCFARTYSYTLPTFAFAKSNELTSAAFRITDETINEISSVLQIFVGTHNFFNYTSKKQYDEKSCCRFIHSFKCGPKRLFRDEIRNEDVEFITIFIKGQSFMLHQIRKMIGMVIAVCRGFAYKSDIQKSFENARLDLPKAPGLGLVLERLHYDYYDKKFANLHGSLSYWGDTIENAVEDMRECIISDILKKEVTTYNMLSWISSLINHDFSENDDSAIPPLAIAGGIALGKITVVQNSMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDH0</accession>
    <name>A0A0N4UDH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein lap1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9181</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDH0"/>
    <dbReference type="STRING" id="318479.A0A0N4UDH0"/>
    <dbReference type="WBParaSite" id="DME_0000538201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000538201-mRNA-1"/>
        <property type="gene ID" value="DME_0000538201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="583"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="707"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="841"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="938"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000538201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1488" mass="162591" checksum="11AFD93AB5B8F5C3" modified="2016-06-08" version="2">MPFSCIPLFACNRQIDLLDRRQCNLQAVPNDIDRNARTLEEIYLDCNHIKDLDKPLFRCRKLKTLSASENEIIRVPPEISHLAFLEELNLKSNGGMKEKVIILDISDLPEEIKECARLKILDLSSNPITRLPATISLLTSMTHLGLNDISLTQMPHDIGLLRNLRSLEVRENLLRTIPSSISQLTQLQRLDLGHNELDDLPSEIGLLTNLEELYVDQNDLESLPESIVQCRSLEQLDVSENKLMVLPDEIGDLERLNDLTIAQNCLQILPNSIGRLKKLAILKADRNAITQLTPAIGSCSSLTDVYFTENLLAEIPSSMGNLKALRTLNLDKNQLKELPSTIGGCISLTILSLRDNLLEKLPLEIGRLENLRVLDVCNNRLNCLPFTINVLFKLQALWLSENQSQAMLKLQTEQDPRTGIKVLTCYLLPQSICAHTERTPTNRSFIGGPKVHFGSDLEETKEEEEGEASIGQFARHDTPHPKPHAPKFKKQSIDGHVIHHDEDHSNKPPSITLNSGRKRNSDDNRAASPLIDAATINTPRSALKHPPASPPSLPSSVELTVNNAIDRRSDVHNIPSVGVETLRVKICRDLNGGLGLSIAGGLGSTPYKDEDNGLFVSKLAEGSPAQKAGLKVGDKILRVNNTDVVNVRHQVAVSTMKDAGDVIELTILRDSRSTPATTAVYQVTPNQSLDTSIRSETSISSTKETISTTIKRDAEGSPGFAVAGGKGITNSETIVISSITPGGAAERDGKLRVGDRVLSINGVNMRGARHDQAVALLTGHSGKEIYLVVQRDHNYINTSNSPPTVLLPYSWSSASQPVSLPAASQHSFITGDSSWDGKIEKIELTRDGTSLGLSIVGGSDHCSHPFGINDPGVFISKITPNSPAARCQRLRVGDRILSVNDTDIRTAKHQTAVEVLKNSEPSVRLLVIHEPQPPGMREVIVRRGAREPLGISICGGVGSPPSNPLDKTDESIFIEQVERGGAAAAASLVAGLRILEVNDISLLGCSQEQAARIISKAGTVVKLLVCDAFSSSYSKPIVSAHTDHTSRCEKPVGNTVNADKNDINLHHSSVDSSNIINAGSTNSFPSLASATSHPVESSPTVDEGPLAASSPIPVANIAQSVHELPSASSEASLSQTQAQSIIQKSEPPPIAPKPRNIAKQNGASVHNLLNAGLSHEDETTDYMKAPSPTILTTYPERLEFSSKLRKFEHEIEVKKPAGVSYIKTTFPPAKKPLISEDDVRKMKEEECKRVGVSGISLSPADDDISSSFEHILNNSAVPRSIPTIVRTKKAENRITATSPLPSDSGEPLNPVEQRALEHQKRQEWRQARYKSLEADSAAAEEVMQQVQKINNVRFLSFTWTDTVRKNFERIDRPAIYGLRRWKKKWLPLLSTMASVLVAWKRLTLVAVGASLTSNANINEESNSVLISPLPANEKILQNETSFERNEYIDPITGATTISYIERSITQREVDIPALLKSDFGFADEASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEF4</accession>
    <name>A0A0N4UEF4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rap guanine nucleotide exchange factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9352</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEF4"/>
    <dbReference type="STRING" id="318479.A0A0N4UEF4"/>
    <dbReference type="WBParaSite" id="DME_0000575901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000575901-mRNA-1"/>
        <property type="gene ID" value="DME_0000575901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF327">
        <property type="entry name" value="EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="241"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="387"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="673"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000575901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="858" mass="98943" checksum="C374960D0A7A5189" modified="2015-12-09" version="1">MYNFTDMRQQCTELSNHSSRFHRQCSMEDDDGVVDDEAYSHWHLPSSLYEIASSASLESRITEVGLIIKRVMQTRAPYLIRDRKAHLQVNRQSEKKRNFQIYPMCMVGTELVNWLSQLSTEILNEMATPLTRLQVVGMWQVLLENGIINHVNNELQFVDKHIYYRWAMNEELDSFKTRDRSGNETTDLETQTNLNDLKSAIFFLSTVGPDALFRTILSKSSNERTAEELELVYDELLHVKALAHLSTMVKRELASIAFFEQHQHAGTVLFRQGDEGNCWYIILKGSVHVSVYGKGIVCTLREGDDFGKLALVNDAPRAATVTLREDKSQFLRVDKVDFNRILRDVEANTVRLKEHGQDVLVLEKIDKPYSLAVDPYCEELETSRQQFRYSVMAGLPEKIVEYLLETRIDAYEDNMTLDTFLEEFILTHSIYMPENILCNYLKNYYMQGSTVILARIDEFYILDDRGQKFAIKRRVVIFLAIWIRTIGQRFFLNPVSNSFVEELYCCVLEDSRQIPEMYSILEKMAYIRQLRENSMQILNRHSVVVLDCGVYSIKAPAPNPVLPFDTCNQIIHLPDTSSFTINIRLDKTSAEICELTKMKTHYGGTNVDLQLVEVRSSGERIIFSPTDISIPTMLSLNSRLYVAYGAEVNTLTPVVQQDGPVDSAHSQMLEYMSSVDIAQQLSIFHFQLFEATDEVELVTQVFGRDQFPSCIPSNLDLLIRRFNEVQHWSSTEILLAKSQSKRVALLKKFIKIATHAKENRDLLSFFAITLGLSNIAVSRIAYIWNRLPSKMRRQYAEFEGLLDPSRNHRAYRMLVRKMNTPIVPFVPLLLKDLTFTHEGNKTYFGGLVNFEKMEPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEF9</accession>
    <name>A0A0N4UEF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9357</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEF9"/>
    <dbReference type="WBParaSite" id="DME_0000576401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000576401-mRNA-1"/>
        <property type="gene ID" value="DME_0000576401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000576401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13057" checksum="FC787A961488E842" modified="2015-12-09" version="1">MAGLLGLIRWMDEWMDGWMDGWMDGWMDGWMDGWDPQKSRPPRSLFALSSNPSVARVSRNAGGLAARPVLFNNRFIAVAGQISILGNVCLPIPPPDISFTRSNFGFDLSIIVSSKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEQ2</accession>
    <name>A0A0N4UEQ2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9396</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEQ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UEQ2"/>
    <dbReference type="WBParaSite" id="DME_0000587201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000587201-mRNA-1"/>
        <property type="gene ID" value="DME_0000587201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000587201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17138" checksum="4E245AA54982443F" modified="2015-12-09" version="1">MSIGELFGLDKIFRFMKIIKELGGIRATLKKRYLMDETRSGTFVGEDKFGNRYYEDKSYNVPRSRWVEYPEYRWLEYDASQIPPEWHHWLHHMTDKTPVQNPPVQRKWILGHEENLTLELDKKYVPYSTTRSKIVGWQPKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF80</accession>
    <name>A0A0N4UF80_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iso_dh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1018</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF80"/>
    <dbReference type="STRING" id="318479.A0A0N4UF80"/>
    <dbReference type="WBParaSite" id="DME_0000607901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000607901-mRNA-1"/>
        <property type="gene ID" value="DME_0000607901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000607901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35555" checksum="CC3EE1DCB52BAF4A" modified="2015-12-09" version="1">MMSHVMRIFRFANVPVDFEEVELTSSLADDSLENAIIAIKRNGIAIKGNIETKFDDPAFKSHNVELRKRLDLYANVLHCVTIPTIPSRHKNIDIVLIRENTEGEYSGLEHEAKKGIVESLKIVTRHNIERIARFAFDYAMLNKRRKVTAVHKANIQKLGDGLFLKVCKELAASEYPSLELNSMIVDNASMQLVSRPQQFDVVLMPNLYGNIISNIVCGIVGGAGLISGINIGSKYAVFETGTRNSGTILAGKDIANPTAFICASLDALRYLHLDTYADLISHALYKSLTVQGMHTKDIGGDKKLSEVIEAIIDNLRESQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFA2</accession>
    <name>A0A0N4UFA2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1041</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFA2"/>
    <dbReference type="WBParaSite" id="DME_0000610201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000610201-mRNA-1"/>
        <property type="gene ID" value="DME_0000610201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000610201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17227" checksum="3251F03185CD6259" modified="2015-12-09" version="1">MGKISKNKLDDALRTAATGKKVNVDKMLTSLSASFLKHSIVFVPSSISSNVSPDSNPRHILLKANSEKRLRSFTKTNKKSVRREEKALRIARFQEPNISAKKMNNSSEQRDIQYRKLKSKVTYKSKDGEIFAMKQMSFGENTNDMIRTRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFF3</accession>
    <name>A0A0N4UFF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9457</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFF3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFF3"/>
    <dbReference type="WBParaSite" id="DME_0000616101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616101-mRNA-1"/>
        <property type="gene ID" value="DME_0000616101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065037at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231459" evidence="2">
        <location>
            <begin position="21"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="808" mass="94766" checksum="EBBC61430ADF5FA8" modified="2015-12-09" version="1">MNCRCTKVLLILVHIVLVFTINDPYLTLGLSKKASNREIRSAYKTLAKEWHPDKNSNPGANEKFMEITQAYEILSDPSRKDRFDRYGTFDEPVNTNVYTFDPFNGFFGYGYNGFDSGNSFFQKHRISNRLFSRTILERSNFSPVMIFAYSGYCQLCFRLESVWQSVVEDIEPLGYGIGTVNAMSDGNLLERLRVSRLPSIVVVVEGRVIHYRGNMQSLSAKAVRLFARDVIPSVFLARINNYSGLRRFIDQWRTTNKISVLIFGNKEEPRMRYMLPAMKYSTFARFAYIYLNEHSLEIAKMREALDIKNLNSDTILIFNDYPQNGPVARLSVEQNQMSVDSIRSFIESNKHLILPRIASQAHFDDLCPISPRASRKLCVMLAIMDSSYDLKFENILRDFVRRAKSVNKPSELQFTYIYINKQEDFIKPFFESALQINHSFKSNKRNIFVIWRLEYTRARFVWLDDIWDENQISMDEIHFRNKIDEIISGTIKFENAITIQKLIDEYRPSWFTRLSRAAIRMTETAWFHLTKEEALPVLSAVGTFLVILLVGYVLSYVNNNDKMHQVKTFWVFFSDRKKHSDKEAEQWHPEDPHVNSGNRTKISRQQRIMREMQPFIHELRAETYFGMIRLLKPGCRSIIVLTDAESKEILLPQFASYLWPFRNNKTFSFGYLMVEKNLDWFRKLLEHTLPADTDDFSQSSLSSRLHNINPKRTLGTVLVLCGWKLYFNMYHPMHTSSKRKNFLGFDDDGDMISSDDSDNERSDRKEIIRKSHQLKIEDVLNGLTNWLDRLFEGSVRRYYVPEWPDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFV1</accession>
    <name>A0A0N4UFV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1233</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFV1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFV1"/>
    <dbReference type="WBParaSite" id="DME_0000633601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000633601-mRNA-1"/>
        <property type="gene ID" value="DME_0000633601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000633601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22027" checksum="1200B00FCA9B8AE2" modified="2015-12-09" version="1">MSLDNHVFNLKFAAKELQRNAKRCEKQEKEEKTKLTNAIKKGNMEVAQVHAENAIRKKNEALNYIRMSARIDAVAARVQTAATQKRVTQGMSGVVKAMESAMRSMNLEKVQNLMDRFEKDFENLDVQSATMEGSMNATTTLNVPQAQVNALIQEAADKAGLELNLEMPSQATTTIGGRVGTSTAENDELTQRLAALRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFY2</accession>
    <name>A0A0N4UFY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFY2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFY2"/>
    <dbReference type="WBParaSite" id="DME_0000637401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000637401-mRNA-1"/>
        <property type="gene ID" value="DME_0000637401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF46">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000637401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31799" checksum="D90DAB3B229C5C89" modified="2015-12-09" version="1">MEHLNLNGADQAAIMDLITELSGIKDLIIANIANMKLLRVIRSIDFEDEIFQANVRLEKAFTNLKNGLNSEQKTDLDVSGFALLQPNQMNELLQAHGVNDPKKIELDIQAYSGLNKHECIENIWRSIKKIALGEKELKRVKRFTIFKKPGIFALSPFIFSPGTGLTVLGPVILSPNVFSPNILSPAVFSPLIFDPDVLGPFILSPYVLSPHILSPLILAPFVLTPYALSPRTVSPYVLSPLVLSPYILSPTILSPQALGGFFLSPRMLSPAIISDQFLSLNVLSPTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG50</accession>
    <name>A0A0N4UG50_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG50"/>
    <dbReference type="STRING" id="318479.A0A0N4UG50"/>
    <dbReference type="WBParaSite" id="DME_0000644901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000644901-mRNA-1"/>
        <property type="gene ID" value="DME_0000644901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000644901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23969" checksum="A9BD0241F0058165" modified="2015-12-09" version="1">MIGEKSEKQKLSRIEMMECAFLDPIDYDKRVILGKCPKTPDKKFVESHLPDFLRQKIKKLDKKRISKHSSAKRRLLKAVFIGKKSFYAVELRNINVNLELIEGLYLILRCSAVSDQKNAKEKMEWFINGIKLTSQLNWRININSENELVIWPLLSGLDDGKYECYEDHESKGAVSLHIISVKANIFFHRMQFLIQSIIQNSKFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGE6</accession>
    <name>A0A0N4UGE6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1293</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGE6"/>
    <dbReference type="WBParaSite" id="DME_0000656401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000656401-mRNA-1"/>
        <property type="gene ID" value="DME_0000656401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000656401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23869" checksum="748692FA77195D3B" modified="2015-12-09" version="1">MTNQNLNKITQFYVNVTSEIYEMNEVIRMVLRISRNLLTRHETCQLCKDARSSFSTWICGYLTSGRKFKLVWISFCSHTMHDEGHSASSFAITVVFWRSWINAVSICPEMMPQRLPLLLCFGGSGLKRGTSEIRVEKITGCLSLKADGDSLGRATAIPRHLFSTTPLSSTAPLGTRASMINSENISNLSTRFSVEATTDISGCEVALIARISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGI2</accession>
    <name>A0A0N4UGI2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1332</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGI2"/>
    <dbReference type="WBParaSite" id="DME_0000660301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000660301-mRNA-1"/>
        <property type="gene ID" value="DME_0000660301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF3">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000660301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11810" checksum="C27E79C3E64F381C" modified="2015-12-09" version="1">MALNVDPPNGAFPASGGTLVFKILNQIDTRLAFKVKTSNNDHYRVNPVYGFIEAKQNTDLTIIRLEGPPKEDKFVIQWAEVPDEESDPIAPFKAGVAAGEVVFPVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGJ4</accession>
    <name>A0A0N4UGJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1262</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGJ4"/>
    <dbReference type="WBParaSite" id="DME_0000661801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000661801-mRNA-1"/>
        <property type="gene ID" value="DME_0000661801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000661801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19736" checksum="38B13E4782B31510" modified="2015-12-09" version="1">MYTRKKIGYQCSEGNIEGDLVRVYKLLLCPSIEKERDNFSDGRFKQQPSGSLNPFMINLQSLLQNILKPSPFLSHLQHRLQPSFLQPHIFTSTSPSLIGVQQTIFNDTTLAETRKQKLHKRRITTEGEIRRQRKENIEGLTKMHDGTTGEDSVINKPPNLPGLVTFRSSKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHA9</accession>
    <name>A0A0N4UHA9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9753</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHA9"/>
    <dbReference type="WBParaSite" id="DME_0000692101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000692101-mRNA-1"/>
        <property type="gene ID" value="DME_0000692101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873432at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000692101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41384" checksum="2C6097C8FB4697C5" modified="2015-12-09" version="1">MFIYVYILTSSNNISIGLVASRGYRRQDISLILTCETIEQLYPWINIPYGILKMEREDCYYSHLFDPLIDKETKHSCKPREYIAGITRLTNTRIQILCCRLRTRNEGICSEQKFAKPFGLTGRTEIFYRSKLINSIAVEGQYYRARFCDLVPRFIDQIYGDERAITMPTKDLTASTASTTASYMQSKYKSDIYNTKLALTEKWTPRPKTTISNKKKNWFEKMKKGLETTACKSWKRTTNTATSAPTRTLITTQMPYRISHQGQTSNKISTTSRVTSMSSKRTIYPEEISGLSQSGSVYQKINVKKQWKNPLLHSSDQTHLNSPPLAHLPSNKIDAHAFIKENFDIFNHSTEGFIVESLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI83</accession>
    <name>A0A0N4UI83_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decapping nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1721</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI83"/>
    <dbReference type="STRING" id="318479.A0A0N4UI83"/>
    <dbReference type="WBParaSite" id="DME_0000730301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000730301-mRNA-1"/>
        <property type="gene ID" value="DME_0000730301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000730301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46528" checksum="50FDC8E7620EE242" modified="2015-12-09" version="1">MAAEGFWLFEGLDDEPYGLLPLINLSGKGGPTSTKHVERIGSYQWYLNDETPTIVVPGMPPESLYWPGGRLQQDHGVVIYDVNHLKVPNGPLDCAILAARHLTAKSKKPINFNDYDFITDAVNLQKLFAFAQEAGDGLFRIDVERIGKTVLLTRMEASDLMEIGHVTFDQALKRKMTKSRSKYTTGPFYQLVSYQFGDFKILARYEVDCGDFASIHSQKIRINEKSENERFCWDEFNLTEFSMDETNVEMEKEPEKRKFPENESIAYIEHGGVPNNLPNQLLTTYPQGAGFPFFTWAQLFFTVADQVVVGWFKGNGDFGKPAMNTLSDISKLIKPLPYVVLSKIHDCLGKIAKFMIKNDPQFKCGLIWKGKNHLEIFAKDSSCNGAVSPGVKAFLKTQCIEPESENQDGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIC2</accession>
    <name>A0A0N4UIC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9983</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIC2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIC2"/>
    <dbReference type="WBParaSite" id="DME_0000734701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000734701-mRNA-1"/>
        <property type="gene ID" value="DME_0000734701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF51">
        <property type="entry name" value="CUTICLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000734701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22223" checksum="BFC0E16F424AE963" modified="2016-06-08" version="2">MSSSSSLFIYHIIFVLISYKFFYFIQAVPIDNGIIDKPEIGCEPIDITVSFSTKNAFYGHVYIKGRYDEPGCRSDENGRKIASLTIPFNTCGLSRVRSLNPKGIFITAVVIVTFHPKFLTKVDRAYKVQCFYMEADKTITTNIVVSDLTTALAAHNIPMPVCRYEILENHPNGNPVSYALIGMQVYHKWTCDSQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIY6</accession>
    <name>A0A0N4UIY6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab-18-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1857</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIY6"/>
    <dbReference type="STRING" id="318479.A0A0N4UIY6"/>
    <dbReference type="WBParaSite" id="DME_0000759001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000759001-mRNA-1"/>
        <property type="gene ID" value="DME_0000759001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000759001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20532" checksum="E174A6BC58E8FB04" modified="2015-12-09" version="1">MLRFVDDKFDPEISATIGVDFRVTSMKVNGNLVKLAIWDTAGQERFRTLTPSYYRGAQGVICVYDVSSRSSFARLGHWMTEVDAYSTRSDAVKMLVGNKIDKVSFLSTMKLNREVGREEGLEFARKHRMLFIEASAKTREGVQCAFEELIEKIIQTPGLWDSDRSAFSLGSTTAQESGYCGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJK8</accession>
    <name>A0A0N4UJK8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2001</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJK8"/>
    <dbReference type="STRING" id="318479.A0A0N4UJK8"/>
    <dbReference type="WBParaSite" id="DME_0000785001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000785001-mRNA-1"/>
        <property type="gene ID" value="DME_0000785001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000785001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20583" checksum="30DC15B19C8BA7BF" modified="2015-12-09" version="1">MLNRRGSDYERLKESFTSHSEYLKFIINELEAANIECRIVRRFDYNENVIAWADAIFSAGGDGTFLLAASKVKSSHKPVIGINTDPLRWLFRQRIRINLRGVKCRFEMFQNQYIQENIPTNDKAEDRNEQTVILPELALNDVFLGESLSSRTSYYEVQVDNCKSQKQKNSGITVCTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKH8</accession>
    <name>A0A0N4UKH8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2296</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UKH8"/>
    <dbReference type="WBParaSite" id="DME_0000822001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000822001-mRNA-1"/>
        <property type="gene ID" value="DME_0000822001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD synthase middle" evidence="14">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="143"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000822001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38728" checksum="89E0329A4BE029B0" modified="2015-12-09" version="1">MFRHDDLDFSDIIFPKILPFFFRTIYIKSNEFGFSNIVSQIANKYSEFVSIGSYPVTNNRYYKAKLIVESESAKIGEEAMKDLKNALKDHIVYYDDKAWENVVEKYKSYRERELFESSDDFIKRLDDAMNTIGNIIDTYPLENIALSFNGGKDCTLLLHMLRVKVDEKYGSDRSIQGFHVVCGDLFPDVNQFIIDSAKNYNIVVLELPGPIKAGLEQLKAVRPKISVILMGSRSTDPGNMNSKCEWTDPGWPKYFRVCPILDWNYADVWRMLRGLCIPYCSLYDEGYTSLGERDTTFKNDALKVVDCEGQIVGYRPAYMLTNFSLERSGRNERRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULH2</accession>
    <name>A0A0N4ULH2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2562</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULH2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULH2"/>
    <dbReference type="WBParaSite" id="DME_0000864701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000864701-mRNA-1"/>
        <property type="gene ID" value="DME_0000864701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="291"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="629"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="910"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000864701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1502" mass="169296" checksum="6453BB7EF614FE04" modified="2016-06-08" version="2">MDGWTLLNETDIIEKLPEQFNEWLESKKWTERRDALQALQNEIVKTPRLSTNVNYSDLVTNLRNVLLKDANINVCALAAKCISGLARGLRTKFGPFTSLFVPIIFERFKEKKATLRDPLIECIDAITSTVNLDSLVEDLITSIDKANPNTKLQGCNFIYRAMKKYKQTTAPKKIIKAISPLLVKFTSDSDAEVRDAACLALGSVMRLTGEKIMVSFLGNVQEDKTKMKKAWKLLSLRFSMDQTVAEIAEEEAHRLLEEEEENSSAIISNRSSSLKDTDEVITVISETDPWDMLSPVDILPKLPTSFMEGIESKKWQERRDALQSFLCLCNDNPRLCPKASYGECVAMLRKILEKDANINVCALAARCITSLANGLRKKFAMHVNLVIPVIFEKFKEKKPVLRDPLIDCIDAVAATTTLEAIAEDIQAALEKQNPNIKIQTNLFLYRIFKKHNIQTVPKKVLKALAPTVIKHTADSDPEVRDASYAALGAAMKAVGEKPCLALLADIVDDKVKMGKIKDFCDKARQEAGPDVVSVMVQSIHKSNPLKPPAPGVGSKQSGLMNFGRKAEDDLKEEDKHVKAPSVNGTLSKEIGESEKKKEELLQLNKEKATRLRDEKNLKLLKWNFDQPTAEHVEQLKNLLSSIAQPALFLLLFHKDFKQHLKAIDLLHSVMVENPEAMLANSDLILKWISLRFFETNPTVLLRALDLGEIIFTHILRYEESFSDAELASFLPYLLLKLGEAKEAVRVPVRSILHLMKEILGANKIFPFVLDALKTKNSRQRSECLQFLEQLIDYAGMAAMANPASSMKQIASCISDRDNNVRNAAINAVVAAWKEEGDRIYQLIGKMSDKERVMLDERIKRSAVVTKNKGSFYFMDIFYYLIYCWSMFLDCIERRNVNALQQNRIRASIGTGLKGGKMRSARSTSRVGSRPASRQSCSREISPAEGKELNKTYTQKSDALIDQSNGPPRRFALDLSGLELDNIYPSVERALNDTKKLEVPEPIEPVVRQRMQQQAFSRRAESVSSITSLESSAGEVDKVVHGIASVSQATASAAISQLQFLFGDTNTFHFVAERVDAVVQALVTQTSLIRSRHLDDVTALNDVNELVRTICHFLSSLVKEPATCSRMSADALKMLIQEFLYLLRDERMVQLKDSQWIFRSLNYLSIRTCDNADATSCFLALCSMLNSALKDPRNKTVELIIKCIYKQSESFLRDVPLDLDVTVKAIHDFLEEFRPKAEENESIKNAIHSMELCIQRLVAGTKAAVIFINSFLFSWYLTVDNIKYSKVVDHVRLIPNPESSEAIIYMQKCVRGLKNKSSQSSLTSSVCGEIPGQVLTSNVEESVQHLMNKIVTDPFGKGIRLLHTYLKVNPEGRKYIDDALKKHDKLKDFVIYHLKRMEHNDRDEPEISLELKNALEFVKEIRNLKNYHPANINASNGLDSINQPLTTIQDNKFASRRSTVNNKTLINEVAPENEGTTVSHRRNIRASDVEALKQHLNKIRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULN3</accession>
    <name>A0A0N4ULN3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10447</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULN3"/>
    <dbReference type="WBParaSite" id="DME_0000871401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000871401-mRNA-1"/>
        <property type="gene ID" value="DME_0000871401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8119348at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000871401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7679" checksum="534AC98ED676934E" modified="2015-12-09" version="1">MSVFCVKLLGMYHQKQSQMRRVHSLQPELSGCRTESRGSKLGSGEVVAVSQAPSPESNPYSPLPVTTMVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULY4</accession>
    <name>A0A0N4ULY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10487</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001220">
        <property type="protein sequence ID" value="VDN60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULY4"/>
    <dbReference type="WBParaSite" id="DME_0000883101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000883101-mRNA-1"/>
        <property type="gene ID" value="DME_0000883101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000883101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10752" checksum="0440CD39C84A51A3" modified="2015-12-09" version="1">MSVVQKLPTYRVWIYTIGCLLMIIQFIIHLFGTIGAYINKKMIVRLYWICMVPTIFLDLLNAVLWALRLQKVHIDYTEFLNDTMQQLTNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMF9</accession>
    <name>A0A0N4UMF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2822</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000082">
        <property type="protein sequence ID" value="VDN52849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMF9"/>
    <dbReference type="WBParaSite" id="DME_0000903201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000903201-mRNA-1"/>
        <property type="gene ID" value="DME_0000903201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000903201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9643" checksum="EAEE4BF5050F1861" modified="2015-12-09" version="1">MYEGTVGVHKKDLHIHITEKHLVTQLFNIGKRKLFSQLMMDQLCATFQIQDIQKEETRRDAMQQTGKLEAIFQYRRYKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMZ0</accession>
    <name>A0A0N4UMZ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA polymerase delta small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2987</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMZ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UMZ0"/>
    <dbReference type="WBParaSite" id="DME_0000925001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000925001-mRNA-1"/>
        <property type="gene ID" value="DME_0000925001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="6">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="5">
        <location>
            <begin position="181"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000925001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50983" checksum="7561DA66C9EBF565" modified="2015-12-09" version="1">MVQLNRKTLSYENCSTRFLISREDFDENCFKRQYFHFYRTRVNLFRQRIIDNAKKLLGEAVNTCHITEAKQNSPVLIMGTIIKRVALRPSILRSLADEEMVLPQPIPAAKLITDDDYIEIEDENQIVRLTGAVDFDDVSTGIVVGLYGKRFGNDAFHVQQFIWPLPAVQPVAPTLDHDKFVMIISGLSFTSENDNCAEEMLALDLLQKWLGGYLPISEKERFVVENLSRLIVAGESIAVTDQGKEFSMAARYLIRNEEAPNVECVAHMDHFLSKISNLIEIDVMPGLGDPATHLQPQQPIHRAVFPHASQHGKMLNLVTNPYHFCLEGTHIIGTSGDNISDLKRFSVNGNSIELLNKLLLWQHLAPTVPDTIDGFPFANRDPFIIEVFPHILFSGNQENVEHSVKQYENGKRTLLVSVPNFAKTNSAVIINLRTLEVTEQNFSYNDFFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN59</accession>
    <name>A0A0N4UN59_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3049</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000100">
        <property type="protein sequence ID" value="VDN53076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN59"/>
    <dbReference type="WBParaSite" id="DME_0000932701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000932701-mRNA-1"/>
        <property type="gene ID" value="DME_0000932701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000932701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39862" checksum="5FFA38189E6DE441" modified="2015-12-09" version="1">MVIESDSSSGGDVSSNIGSELIVTSQGESDVSESTVTSNHSMNTQSTIPSERHSSNFGGKRSSSRSKSFIQKHAIRSNGSSQLFFKTDIVNSPKKFSSDATSYSTSICTLLRKTPSPSDFKILQNFSPSSCHQKVKNKKIDGEYRESNVENMRKKRKSSQKSSESGSSSGKIYQIRNDNARQILQDMKSEQKNFAKSKSDDRYKILSNHFSRTPSSLSDDSAEYRNESILDKTRDEFPRRDGSLEKLKYSEERTIHSDVAFSESQLASSANSSNCILQTVSSNSSSYSFKDDFEDILTRFIKNIIEKEKKTYGLNKNLISSFAQTDDFDEQKLSKALTEEIKGFVCCYIIIVNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNF0</accession>
    <name>A0A0N4UNF0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">small monomeric GTPase</fullName>
            <ecNumber evidence="1">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3134</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000107">
        <property type="protein sequence ID" value="VDN53161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNF0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNF0"/>
    <dbReference type="WBParaSite" id="DME_0000943001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000943001-mRNA-1"/>
        <property type="gene ID" value="DME_0000943001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000943001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20906" checksum="0169898CFE8FA49A" modified="2015-12-09" version="1">MREYKIVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVDVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLMDLREQILRVKDAEEVPMILVGNKCDLEDERVVGKDQGHNLARSFNSAFLETSAKAKINVNEVFFDLVRQINRRYPDPGKRPTGSSKCCCSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNM4</accession>
    <name>A0A0N4UNM4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3193</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNM4"/>
    <dbReference type="STRING" id="318479.A0A0N4UNM4"/>
    <dbReference type="WBParaSite" id="DME_0000950701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000950701-mRNA-1"/>
        <property type="gene ID" value="DME_0000950701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000950701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="50570" checksum="32E9DE17E878CCD9" modified="2015-12-09" version="1">MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGEFEAGISKNGQTREHALLAQTLGVKQLIVACNKMDSTEPPFSEARFNEVVNEVSNYIKKIGYNPKAVPFVPISGFNGDNMLEPSENMSWFKGWSIERKEGSATGKTLLEALDSVTPPQRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPQNLTTEVKSVEMHHEALAEALPGDNVGFNVKNISVKDIRRGSVASDSKNDPAKEAKSFTAQVIIMNHPGQIAQGYTPVLDCHTAHIACKFAELKEKVDRRSGKKVEDNPKFLKSGDAGIVELVPSKPMCVESFTDYPPLGRFAVRDMRQTVAVGVIKAVEKTEAAGKVTKAAQKAGVGTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNU6</accession>
    <name>A0A0N4UNU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000118">
        <property type="protein sequence ID" value="VDN53297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNU6"/>
    <dbReference type="WBParaSite" id="DME_0000960301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000960301-mRNA-1"/>
        <property type="gene ID" value="DME_0000960301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000960301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17164" checksum="621C887C4B43F937" modified="2015-12-09" version="1">MRVSRTKQPLQPHHSRLVNFYIKKHKEINGVIDITKQMHQTLGQQIIIYQSTINFALTEGQLLAYDGNDLGRTEHRITQSGKCVTNNNNSIIELSNCPYKRIVNTIISNFVTSLKPSLNLIAWMAILSSIWDQIRLNREIEGLKICYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP79</accession>
    <name>A0A0N4UP79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3365</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000126">
        <property type="protein sequence ID" value="VDN53392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP79"/>
    <dbReference type="STRING" id="318479.A0A0N4UP79"/>
    <dbReference type="WBParaSite" id="DME_0000974901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000974901-mRNA-1"/>
        <property type="gene ID" value="DME_0000974901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000974901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11621" checksum="C276BC1C92468024" modified="2015-12-09" version="1">MPKYYCDYCDTFLTHDSPSVRKTHNGGRKHKENVRMFYQKWMEEQAQKLVDATARAFTQGRIVPSVGAPAIPGAPRMPMVFFFFFLNNIENADRIFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPB6</accession>
    <name>A0A0N4UPB6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolysin TIA-1/TIAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3406</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000130">
        <property type="protein sequence ID" value="VDN53433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPB6"/>
    <dbReference type="STRING" id="318479.A0A0N4UPB6"/>
    <dbReference type="WBParaSite" id="DME_0000979201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000979201-mRNA-1"/>
        <property type="gene ID" value="DME_0000979201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12353">
        <property type="entry name" value="RRM2_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001013">
        <property type="entry name" value="TIA-1/TIAL RNA binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="300"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000979201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="51792" checksum="0C8905A730BB8B1F" modified="2015-12-09" version="1">MALELVNLFLAFAFYFSPMAYNTYGYGAFGYGQQVTPSYGQDGTMAMTGSSSGTNTGGAYNARYHFQAAQSAGFDTGSEDHQPRTVYVGNLDASITEEFISTLFGQIGAVTKVKVIFDGTSDPYAFVEFADHYTAAQALQAMNKRVLLNKVFYNILFFLNISVIKLIIKEMKVNWATEPGSQAKVDTSKHFHVFVGDLSPEVDNKALKDAFAPFGDVSDAKVIRDATTLKSKGYGFVSYPKREEAERAIEQMNGQWLGRRTIRTNWATRKPTGTGAGDGQYGRSELNYDDVFNMTGPENTSVYVGNVNTNANDEDLRAAFDKFGRILEIRIFKNQGYAFVRFDKKDSACNAIVKMNGQEVCGQSVKCSWGRTPEVDIKILPLGHNTQQQQQSVGAYSQAQAYGGYGGYGGYGGYGNGTPGGPQASAAAQQQYWNYYQQYYNNPQLVQQHWQSYWQQQQQQQTQGQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPF1</accession>
    <name>A0A0N4UPF1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Amiloride-sensitive sodium channel subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3417</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000132">
        <property type="protein sequence ID" value="VDN53444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPF1"/>
    <dbReference type="STRING" id="318479.A0A0N4UPF1"/>
    <dbReference type="WBParaSite" id="DME_0000983401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000983401-mRNA-1"/>
        <property type="gene ID" value="DME_0000983401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000983401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60733" checksum="EC06FBEC9804DFC1" modified="2015-12-09" version="1">MKSIKSRASHLIVEVPVEQLRKFAKTEGMNSLSRETQHFVGICTMHGPLRVYRGKSYSRWFWTSTVTLSIILLLFQVSTLLEIYNSRPTVSQVLFLLPENGLIFPSVTICNYNPIRKSYVDNLKNKGYLSQTALDYISQAYAEVEQLYDNANVSDLRQGHNAFTRINGAYNFSINEFFEDAGFPCEEMLMLCSFGGRYFDCCKYAKTTLTTLGKCQQLHLSSSSDQWMQRQTEAGIDNGLQIIVDFHSEELLGRENGEDQPYFSNGIEHGFRYFVHEADSIAYLSAEGISVSPGYRVYSAITTNKFLLLEKKNWGGCISKWPEGYETKRPYSASKCKALCRAKYFYDYCKCSPFIYNIDGAYKVCSPYEIYTYELGHAYTLPKCSECMVECESWEFHAYNSYGYGFSNGAVRWLNRRNENWTSGHIRSNFAIINIYFRDMSYNEYSQVQGTTLTQMLSDIGGNMGLFLGMSFISCAELIIYLFKITWIMISKKRRQYMVLKKEKELVRFSTREIEFYKILPAVNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPH3</accession>
    <name>A0A0N4UPH3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3441</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000134">
        <property type="protein sequence ID" value="VDN53468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPH3"/>
    <dbReference type="WBParaSite" id="DME_0000986001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000986001-mRNA-1"/>
        <property type="gene ID" value="DME_0000986001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914923at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000624">
        <property type="entry name" value="Protein CBG23324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF12">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000986001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39659" checksum="F33FF2546361ADF6" modified="2015-12-09" version="1">MELLVFSLRSVFCQVSYMDARKLKEGTIMRYKTVLLGKKWKECHAVLFSDSSFCWYDKKGDSRPAGKVLLKDYIPYICVGLLCDRMPIQRPKLPDNYSVHHLVGIGMDPQANKVFWFLFSSDSDLESWFNEITKTLPKPVQPASQLPPNVPTSVPHYILQNWIAYGISDPPAVYPASAPLPPVQQYSGGQPSLVGYSSPPYSSYRPDRGYSSGSSSGPAFGTGLGAGILMGSLLGYGVGSFWGGGFYPSCGFGGHGMAYGMGGGYVQDNDTYITNNYYGGAGPETDAAQNTLDDNTMVGNDVDNIINHDGDTGAVDGNNDHGADYDYRNGDYDDYGGVDFGGDDFGGGEFGGDNFDGGDFGDFGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPV5</accession>
    <name>A0A0N4UPV5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3547</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000148">
        <property type="protein sequence ID" value="VDN53574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPV5"/>
    <dbReference type="WBParaSite" id="DME_0001001201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001001201-mRNA-1"/>
        <property type="gene ID" value="DME_0001001201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001001201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13432" checksum="F33DE4F9F92EDBAF" modified="2015-12-09" version="1">MGVKYLTPEINISFSANTREANCKWRVFKRCILSGLDDLPGTFFPARAVTNQDGCEYDGERAAPRSSIRCNLRITEATAHLILMSDVWASKQIDIGVIRCIIGVRRSLQRNPFSDLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPZ9</accession>
    <name>A0A0N4UPZ9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Splicing factor 45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA-binding motif protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3588</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM half pint family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000153">
        <property type="protein sequence ID" value="VDN53615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPZ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPZ9"/>
    <dbReference type="WBParaSite" id="DME_0001006101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001006101-mRNA-1"/>
        <property type="gene ID" value="DME_0001006101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12647">
        <property type="entry name" value="RRM_UHM_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034653">
        <property type="entry name" value="SPF45_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031066">
        <property type="entry name" value="Splicing_factor_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="293"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001006101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42571" checksum="5B96C0CF5AE4AD90" modified="2015-12-09" version="1">MSLYDIFGEDPVEENSSKASDVKSAKGVSTGLRMLQSQIQAKKSQLAQSQYGDKNELSLINFFKRNVVTPVIDLSARNRSSTTSTILKPHKAIPIGDGFPLSFIPKSLKEDKVFLFGEILVEDEYNPTAPTDYAVHKQKADERKAKEKLAKEIAERLSREHQEEVAKRSAGAAIAPPQILMEEDSKIKPLSPPNVVNEMPPPSFIPSFGGAGKGLGVAANIMTKFGYKEGAGLGRTGQGMSTALKVERLGKNSGVIVNEHEQLLRGSDSPPQIADPAPIPAVNMAEALKQSTRILLLQNMVSADEIDDQLEPEVHDEMKKYGQVNKVVIFRILNARDDEAVRIFVEFTNVAQAIKAFVDLNGRFFGGRSIRASFYDLEAYNANHFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQU6</accession>
    <name>A0A0N4UQU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3867</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000204">
        <property type="protein sequence ID" value="VDN53894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQU6"/>
    <dbReference type="STRING" id="318479.A0A0N4UQU6"/>
    <dbReference type="WBParaSite" id="DME_0001040201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001040201-mRNA-1"/>
        <property type="gene ID" value="DME_0001040201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001040201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17170" checksum="51868F1A9EE19DDF" modified="2015-12-09" version="1">MKGRIVEARAAIEGDGITGTITLKQEGEISSTSIRGQINGLNSGENGLRIYNMSRCTSIGPKFNPNDQLLHNLGNLVVNSTGIATINIITPLQGPRSVIGCIIVILSTIEDFRQNFTQMVVTTHSEQHQEQQQQQQQQQQTRKPKAGCGIIEMIRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQV5</accession>
    <name>A0A0N4UQV5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10897</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001268">
        <property type="protein sequence ID" value="VDN60924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQV5"/>
    <dbReference type="STRING" id="318479.A0A0N4UQV5"/>
    <dbReference type="WBParaSite" id="DME_0001041201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001041201-mRNA-1"/>
        <property type="gene ID" value="DME_0001041201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429597at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001041201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24621" checksum="89978E90FEE2E1AF" modified="2015-12-09" version="1">MLNISVILLLAYNYLDLKCSLHLCEAPGAFVVALAIYLKLHVSEVHWSWRANSLNPYYEWNEPTNMILDDTLIAKSYAKWLFGPDNSGNIFNWTQNYLDYIVCKTGKFHLITADGSFNCQVNSSILMLFKFSLILTIQIALDLLRPNGSFVIKMYTIYRKETVETIFDLFTSFERLYMFKPSSSKPGNPEVSLIFYFDQCLKIIFFLNLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQX3</accession>
    <name>A0A0N4UQX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10904</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001271">
        <property type="protein sequence ID" value="VDN60931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQX3"/>
    <dbReference type="WBParaSite" id="DME_0001043601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001043601-mRNA-1"/>
        <property type="gene ID" value="DME_0001043601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040508" evidence="1">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001043601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16509" checksum="8561FAFE0C1359BE" modified="2015-12-09" version="1">MNFVYLPLLLVISCVSADDKTINEVKINICPYTCGFCDLPGAGGECPDSIDGCESLRGFCQLDSSRNMNLFFKGLSSKSDNAGNDVSIKVCNRPLPLPAAPVAAPPNGAPQPAQEAQYRPTVDPNLCFDLDPACSQVFNLEQPEQTIQDQRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQX9</accession>
    <name>A0A0N4UQX9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3898</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000212">
        <property type="protein sequence ID" value="VDN53925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UQX9"/>
    <dbReference type="WBParaSite" id="DME_0001044201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001044201-mRNA-1"/>
        <property type="gene ID" value="DME_0001044201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF121">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="9"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001044201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46422" checksum="9183945FA4A9833A" modified="2015-12-09" version="1">MFTVKYFIAVATVAIGASTQFYSYGIVNPVLPLVTEWINQTYIERYGTIMNKSQLNIFWSFVVSSMAIGGIFGSLMTRIMADRFGRKNGLLINGIANIIGAFLELIAKVTRSPELLIVGRIILGFNTGLASGLAPIYLMEITPSKYRGAAGTIHQLAVAFSDWFSLLIGLPELLGNDRLWPVAFAFPGIQALALCLILPFCPESPRYILWHMKDKDETMSVIKKFVDEQHANDILHEIIEETSQIKGSYRELFTRKELLRPMMISLLVMITQQFTGCSIVFAYSTNIFVEAGLSLPIARYSTLIIGIAYFLTTCLAPYLIEKVGRRKLLLFQLSSCEIAIILLMGFAFLQNYCEFAWASNGSAIALLLYMLVYGVGSPIPWMITSEMFDTEVKKKAPLRLPRNSRKKNFSEFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR05</accession>
    <name>A0A0N4UR05_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3929</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000221">
        <property type="protein sequence ID" value="VDN53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR05"/>
    <dbReference type="WBParaSite" id="DME_0001047101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047101-mRNA-1"/>
        <property type="gene ID" value="DME_0001047101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847754at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36042" checksum="A24FB756BF9861C0" modified="2015-12-09" version="1">MGMCFDWEKALDAINAFRKELVNRRVRSENANFSKGREMYKMRWNCSLEKMARKKVSECKFGSEYNDDIGETIHTSLEPAISNKPLEDALKNWLKSVENYDGDSLSVCEFTNSFYDFAQIASGSTTNIGCATSICIFQQDYEVDDVVKERKVQFTVRKFWPKQFFFLQRWNCSLEEMAWKKVSKCSYGSSDDEEDEVGEAIYILFRPSGGDFKPLDEPVKEALKDWVKRVQNGFEDNNVSICEFLDIYDTFIQVGKCAKHGSFSNNDKLCEFDYPGNGSSEEKDVEEAIHVPSGGDFRRNFRKKIVEKSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR82</accession>
    <name>A0A0N4UR82_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3985</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000238">
        <property type="protein sequence ID" value="VDN54012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR82"/>
    <dbReference type="STRING" id="318479.A0A0N4UR82"/>
    <dbReference type="WBParaSite" id="DME_0001055501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001055501-mRNA-1"/>
        <property type="gene ID" value="DME_0001055501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001055501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39677" checksum="8CF424F3A0228E82" modified="2015-12-09" version="1">MPLSCRFYANQFPDVEDTVMVNVRQIAEMGAYVSLLEYNNKEGMILLSELSRRRIRSVNKLIRVGRSECVVVIRVDEDKGYIDLSKRRVYSKDLIQCEDRFAKAKAVNSILRHVADQLDYTKEEELENLYEKTAWYFDKKLKKKAAAYDVFKKAISDPSVLDECDINNEIREKLLEDIRKRLTPQAVKIRADIEVSCFAYDGIDAVKDALIKGQKCSTEEMPIKINLIAAPLFVVTTQTMERADGLYAVNKALDMIKTTIESYQGIFKIVMPPKVVTDLDEEDIKKRMELMELEDDMNSEIDDEEEGNRGGINDDGDDDGLVAPKGLDQQADMQEVSHTTNQTAEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR89</accession>
    <name>A0A0N4UR89_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3992</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000240">
        <property type="protein sequence ID" value="VDN54019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR89"/>
    <dbReference type="STRING" id="318479.A0A0N4UR89"/>
    <dbReference type="WBParaSite" id="DME_0001056201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001056201-mRNA-1"/>
        <property type="gene ID" value="DME_0001056201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876342at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001056201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18858" checksum="0B3CBE0A92442C77" modified="2015-12-09" version="1">MELQRNQRITEISHLAPISLCEFNRDPNKWEQFISSFKMMLDQLKIPNVQKFCYLLVQLKGKARMVVSLYAVTDENYPIALNALYGQRENRYHLLFSRLKNIYQVKDDFEAIRQLLMILSQLEAANHDINSEALLMLVESELSRGIYSKIIGVKAVDMEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH0</accession>
    <name>A0A0N4URH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MoCF_biosynth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4072</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000271">
        <property type="protein sequence ID" value="VDN54099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH0"/>
    <dbReference type="STRING" id="318479.A0A0N4URH0"/>
    <dbReference type="WBParaSite" id="DME_0001065101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001065101-mRNA-1"/>
        <property type="gene ID" value="DME_0001065101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007529">
        <property type="term" value="P:establishment of synaptic specificity at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097112">
        <property type="term" value="P:gamma-aminobutyric acid receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072579">
        <property type="term" value="P:glycine receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="6">
        <location>
            <begin position="206"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001065101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43336" checksum="BE14CEAA0DB57219" modified="2015-12-09" version="1">MSAKIYQHNEETFILNKRWNLRESPWPAISVESALAIIDEQKMRTQIKIVTIQEIREGDIIAEKITAARAYPSFRTSVKDGYAVIASDGCGIRMISDSLEAGVNTDLRLREGYVCRVNTGSAIPYGADAVVPVEQTELCGKSADGKLLVKIMVEAKIGQEIREIGSDVAEGETMLESGTQITAAEFGILIASERRLFKIYRRPKIVVMSTGDEIVDYKIICCTQGYVRDTNRPQLISLFKSVPESRKDSITIYIGFYREEVLIDCLGQAFAIADIVVTSGGVSMGTKDLLKDVVLEHFKFKIHFGRVFMKPGLPTTFASGIIDGRSKILFALPGNPLSAWVTSHVFVVPTLKKIVGSSNYNFPVIAAKVIINLLKYRNFINPVRRSERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2I3</accession>
    <name>A0A158Q2I3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4513</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMAUG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2I3"/>
    <dbReference type="STRING" id="318479.A0A158Q2I3"/>
    <dbReference type="WBParaSite" id="DME_0000015301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000015301-mRNA-1"/>
        <property type="gene ID" value="DME_0000015301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.170">
        <property type="entry name" value="Smaug, PHAT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037093">
        <property type="entry name" value="PHAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000015301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="653" mass="74408" checksum="037A4B24ECE07574" modified="2016-06-08" version="1">MGNVPGWLKSLRLHKYTQLLQQMDYNEMMQLTEQKLEKLNVTKGARKKILQSIQKLHERVHQIRQLETSIDEKSGDMACVIMELRNTMNTPIRAFVPKYLARNGYCDREENDGELDDENLPGHIIRLLGKIYSVLVDPCETRLFSLDDEYFYCLDQIFDRIAMHEAFTVVQKRCTANWRLRLRAMHSILNSLRNQKILSYSSTNYSTKSRLSNQCSRNVPMKQANGGTLREALLTRLSACETAAQMVSQSALQTFLETRNAQAAATAYYLGLASITSLLPHYMLSLHDLINARNMQCSPNDYYPQMNDQFSPHIFSPTNQQFHSQHQQHHIQQQRHHHHLQRRHHHQQQQMKVASSKMTFEEMMLQMSFNKPKEPLNQFINSQNMKDSSLMYANNFSQQQQFWNNFYENNSAIFDMQQNSVAKTNSSHNILSKSSDRLDTTSPAMSSKALTQGSSLSSQEASVNESRLTRTYLGSIQFNPLIEPLTVDVSHQPTMINNNKLPSLRCTSKTGNYSNDRALIDQTNNFPMKPSISENLYHHHQSVMSEHKRESDSNATNTWSIFSPSSVNMPPTSPIHVQNVEQLQQYIFPSGNQLSSNACGSGCSSSASGRSSGAGTPPALRVYNFANEQCGMVDELNAVCRDVAALTFNNTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2M6</accession>
    <name>A0A158Q2M6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4800</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2M6"/>
    <dbReference type="STRING" id="318479.A0A158Q2M6"/>
    <dbReference type="WBParaSite" id="DME_0000044001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000044001-mRNA-1"/>
        <property type="gene ID" value="DME_0000044001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000317">
        <property type="entry name" value="Amyloid beta A4 protein-binding family B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="203"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="375"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000044001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59837" checksum="941BCDEEC85BAEBD" modified="2016-06-08" version="1">MSVDYSPCNFQDSLATIDAASRGENIRVHHQGDTTIVTEHRDPYSFYWQLDQVRQHNEDPPRHALPTDYVIDEENIAETVLSPDSHDSGIHIESQYSRPIKVDESQSLLMNPPLPPGWEKHEDPSGYSYYWHIDTGTIQREPPVRNREIQVDVPSAATATQQQLPRQSYQPIIEEHAYKQTTTKRQIDNEFQNDGDYESGKPVRFAIRSLGWTEIAEEDLTTEKSSRAVNKAIVDLSTGRNDIMDNVSKWGDGRELIMEIDDNDLTLIDPDTMAVIHSERIHQIRVWGVGRDNGRDFAYVARDRNSRRFMCHVFRCDTPARTIANTLRDICKKLMLQRRPNTINSLEHKERRIIARDNSLPTPIEEPKKTIRCHFLGVTQVPRATGIEILNEAVDRLLSQVRPDRWILADVSIAPSTITITEVNGNQIAQCRVRYLSFLGIGRDVKHCAFIMHTSSENFMCYVFHVEPSAGPMAKTIEAACKLRYQKVLDAHSNGHLPVNGKRWGDTFWNALGTVKDRFTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Z9</accession>
    <name>A0A158Q3Z9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPX2_importin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7696</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Z9"/>
    <dbReference type="WBParaSite" id="DME_0000369101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000369101-mRNA-1"/>
        <property type="gene ID" value="DME_0000369101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000369101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42021" checksum="4DA5D8FCA58590F8" modified="2016-06-08" version="1">MVRSPSIHALDSPHQFLSVSKQGYSQMEHFASANDEAFTFTFGAFLVHFIDQRFGSYFKRSKMSTRRNRNDEIILTAAEKRRRMIEYASLNYKHSIGPWSLRQRTEKKMALKDPVAYVRECSEQVVLEDRKIEMIEKIPDEKRKRDSLFPNGINPFLAAVEERNKRKQNISELKENLTLNQSRGTSQLSSSVKKLAGSTLEMRTPQLSLHFGQDDLNICLRRISTKNLVKLKAAIEQVQMERTVEESKMNAVDKCNCATTFPFSSEQSKVENSNADLSHSCTKENYCTSTPNYGCHRQLFFPYCGSVVKKIDGINEERQLAQILSNQRIMIPLVSASPSVVIDGLLSLILKIPKVIISSSNASLLCSVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q447</accession>
    <name>A0A158Q447_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS361</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q447"/>
    <dbReference type="STRING" id="318479.A0A158Q447"/>
    <dbReference type="WBParaSite" id="DME_0000399701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000399701-mRNA-1"/>
        <property type="gene ID" value="DME_0000399701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="2">
        <location>
            <begin position="155"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000399701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35439" checksum="132EA4F2425B5DF0" modified="2016-06-08" version="1">MVCPSFIHITGFHSLLYSNYGSVMKPVHDSMFQDVDQPLSHYYINSRYINALERVEIYALTIFSYSSVDIFNGDHGLPCIIHKRTLIKSIYLKDVLVSIYQYVFQHNPFPVVQQHDASFKPLPSTNDLKHRILLRGKILSDEETLVRQDRYSDSLDDFSSIKNDLDHEYSKLISIAVVKISENLNPLNGSVAEGKFTLYSIKRLVKSYPDGFQNSSNINPMISWICGIQCVAFNMQIYDENFDINAGLFQINGNCGYVLKLWVLLDGKKILGLPADSRQFRTKTDFDRTSMNEFIGEYTIPVTSIRTGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q488</accession>
    <name>A0A158Q488_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS8143</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q488"/>
    <dbReference type="STRING" id="318479.A0A158Q488"/>
    <dbReference type="WBParaSite" id="DME_0000426001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000426001-mRNA-1"/>
        <property type="gene ID" value="DME_0000426001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="488"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN58170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000426001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="931" mass="105773" checksum="ED29261EA6A1EFF2" modified="2016-06-08" version="1">MSERSGSRRASQNSSARQRSGSISSRSRHSSRRSARRQLTFEDSDSSNSPPSGAEAANDEIDPIAELFGNELNVEDDQENDTNIGDGEESSEDLFGEDMERDYQAQPELDIYSESGMDDSQYSVLSPSARRAAERQMDRRDGIENEADLFYSREDEEEDERQPRRRKEEEEKEDEDVEDEELPIDIVENLRGRTTRDHVSDVAVAKEIQRRFKNFLRNFRDPKTGKLKYIEAIKQMAAENRESVVLDYDDLASENGEQHICYFLPDAPVQIFGYLSRATTNIVLSMFPHYTRITPEVKIRLRGMPVVDDIRMLRQIHLNMLVRVTGVVTVTTGMLPQLSLIKFDCLACGGLIGPFVQLQNEECKPTTCPFCNTRGPFELNMEQTIYHNYQRIIIQESPNKVAAGRLPRSKDVILTGDLCNSCKPGDEIDVTGIYVNNYDGSMNSKHGFPVFSTVIHANYVIKKDKITSDSLTDEDIKIIKELSRDPNIAERIFASIAPSIYGHEDVKRAIALALFRGVEKNPGKKHNIRGDINVLLCGDPGTAKSQFLRYAAHTAPRAVLTTGQGASAVGLTAYVQRHPVTHEWTLEAGAMVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAAANPISGRYDITRTFAENVDLTEPILSRFDVLCVIRDVVDPNEDERLANFVVASHHMHHPYNFIRDLETENQIPDSEELQQLDDESKVKIIPQQLLRKYFMYARMNICPKLQKIPQDKISKLFADMRRESLVTGSVAVTVRNVESIIRLSEAHARLHLRQNVNEDDVNVAIQIMLESFISTQKASIMRQMRKNFARYLTFNRDNNELLLFLLKEIARGQIYFEKVRRGSASGFGTISIPEYKFLDKAHQYHIENVKMFYKSEVFKANNFTYNARNKTIVLTFFADNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q493</accession>
    <name>A0A158Q493_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAT1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8173</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q493"/>
    <dbReference type="STRING" id="318479.A0A158Q493"/>
    <dbReference type="WBParaSite" id="DME_0000429001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000429001-mRNA-1"/>
        <property type="gene ID" value="DME_0000429001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000429001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="676" mass="77035" checksum="E685287F120D1CE1" modified="2016-06-08" version="1">MSLLGFSGTHPPNNDDDDGFDFPVLPEDEIGDNSLVDDIDAVNAETFGTDIDSFVVGDLEEYSKQTAKLQLDLSDWANEPSCSAENRIEGDLQKLVLHDSVQTTYNLSYNGNIESNKTIMQKSPLGALTLEEVESDVLRSSRQCLPSVHSFPSGALSVTELERRILSESQNRGATIPRIPSLSLQTDQGPVQQHFPPSMSVLPRIPPPMIMQAIRARLSGQYHELPLRFSMMPPQMHTNVLPMLTNNPEMALPLPMRIHYPSRMPPVLPPFPLHHPPLMTRVNQHRESQRKRAAGLPSGKTISDFALSPYAGFMSQKEVEWLIKIQIFQCQNSGNPYEDDYYFTARYFLIHLLVWKQRQNESLPKTGSIRIVKRELSNNSHPHHYEPPQFIGSLGKPSLSTASNPRQLISLSDDTNDPDDDVDKNATAKKPQRRLRALLILIENILRMIIECDDRSHQMKSPTSSKEVKEILANDIRSRIEVILNSPCFNEWMHATLLFDKGRQMITRTLKYTTEIQNLRVMSNLFPALQSSLKKVSAEELNTSFLNSIFIIFSNFSANNFRKAIKSVPIELFAENMVKQSNMFVVNLMLILLYCLMWHFNENSSIFDTPIIFWLRSRDVQISFPKDWSLRTMSSVIFNIDCFVALQQWLSKLFYGRGGCIGEQIARILHFHKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4I2</accession>
    <name>A0A158Q4I2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS530</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4I2"/>
    <dbReference type="STRING" id="318479.A0A158Q4I2"/>
    <dbReference type="WBParaSite" id="DME_0000490901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000490901-mRNA-1"/>
        <property type="gene ID" value="DME_0000490901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431034at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF831">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="95"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000490901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29190" checksum="C23626694626F865" modified="2016-06-08" version="1">MEAIENENVPNDYAEVRNLLRQYYSRAARKYGTSFDYNSQKINEALKNTPFDDGTEVSVNRNEGIVGDLFENDILLTLPQAKVILQEIKSKQKRQAIRAKEYFWPTTTIFYTFGISDARWQNIIKLGLKHIESKTCMRFKEGIAREGIFFTRGHGCWSAVGRIGGQQVISIGYGCDSIGIIIHEVLHALGLWHEQSRTDRDNFVQIIFRNIYQGTQGNFEKRSVYNTDNMNQPYDLGSIMHYGPKAFTFDYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4V8</accession>
    <name>A0A158Q4V8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS9381</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4V8"/>
    <dbReference type="STRING" id="318479.A0A158Q4V8"/>
    <dbReference type="WBParaSite" id="DME_0000585701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000585701-mRNA-1"/>
        <property type="gene ID" value="DME_0000585701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF503">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="296"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="772"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000585701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="952" mass="107648" checksum="B439C9818D39989B" modified="2016-06-08" version="1">MHEPEVLQLCAKDLKERHILPHNISFQIITKPSCYKYCGVENAAYLHIMHNASLFLGPGCIEEMTVIGQLVSQWNATIIAHLSGADYLSDHSIFSTLGSVTLTAAHEMARAIYALLQLYGWQRVHTSIYYFFLLIYPALLANLIFSFFIIAIIKPITDSEKLSTHGLLAFTKYGLTINDEIIINPQASVDDIITNDYYPWETANSNKEEIKNAYADTLLITPNGYNRNFVKNFQKKFSQETGIIDNFVSDFLDTNYSTLVYMGLYDALYLYGLAVRDAYDITGNAGIHEDGAFIWSKMARKQFIGTTGKVLTNNQAERIPSYTVSRVVNGTLQSVIEFEPKLSEQSKCKVKRDCTLQIPHEVMFNYWPLPNGMMPTDFPSCGYDGSLCDPTMYFIIAGLTILTILLVTSGYGLYKIQYNRMIYDMIWRIPRNTVQMNDDTCTKSRVSVRTSICSSGKTENAVCGGVQLNVIKYLQLKNISFSKQYLRLLKEDVLFNGDLKLERNFQISFAKDVIKGMSFLHSSIIECHGFFCLQNCLVDSNWNIKLTNYGLYTMIHEKLFANEIKAVEDDQNNENELHKSKRIIKGYVQQAPEVIRVILATKNLPKPTQAADMYALGMVLYQILFGLEPFYEQSSEKLLQKIAMFNDDDQDQCVRPTFPNRPSEENYNLQLISGIEACWLELPEMRPNMKKMKAIVNSNLKSTVKGSLVDQMVKMMEEYAANLEGIVQDRTALLEEAQRQADKLLYNMLPKKIADDLKMGKYIPPQLYPSATVLFSDIRGFTMISATSTPLQIVDFLNSLFSGFDAIIADHDAYKVETIGDAYMIVSGVPIENGNTHVENIADIALKMRDFVSNFKLAHKPDEKLMVRIGFHSGAVAAGVIGTAAPRYCLFGDTVNTASRMESTGIPNQIQISEQSYNLLNCFYPKFKIVERGKVEIKGKGECTTYFLEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Y1</accession>
    <name>A0A158Q4Y1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS937</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Y1"/>
    <dbReference type="WBParaSite" id="DME_0000599801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000599801-mRNA-1"/>
        <property type="gene ID" value="DME_0000599801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5811720at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF48">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160570" evidence="5">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000599801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16680" checksum="A8A4E46D504FE11E" modified="2016-06-08" version="1">MRFILALLALICFANCADVALRSVSVKGTLLCGKEPYGNAHVRLYRVSSKDDHEILEQKQTLSNGEFRLEGSTQGRPANETTMTPVVRIYHKCDEEPDKDTYRRFQLQIPSIYVTRSRVSRNEYDIGKINLQLIYPREESGIRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Y4</accession>
    <name>A0A158Q4Y4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS952</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Y4"/>
    <dbReference type="STRING" id="318479.A0A158Q4Y4"/>
    <dbReference type="WBParaSite" id="DME_0000601301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000601301-mRNA-1"/>
        <property type="gene ID" value="DME_0000601301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="76"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000601301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43913" checksum="D27EF995331A805A" modified="2016-06-08" version="1">MGGDEEICSMARTQPICTLQELLQWNENEVSRELIGEKLENYKGRRGNRETLLCHDMRGGYLPEERLEGCVINELTNPYIFFHWWYIDIFVYFSHNFITIPTVGWINQAHQHGVLILGTFITEWKDGEKLCAELFDVETVVNVVMNMVKIAKKYNFDGWLINIENKIKEDCLESLALFLQLLTDEMRFAIGERSRVIWYDSVTVNGELKWQNDLNNNNLRWFNLTNGIFLNYAWEKGNLKNIASRAKQRINDVYVGVDCFGRGCHGGGGWNCYEAFACARENNLSVALFAPGWIAENFLHRDIIMNSLRFWDRLASLVSSHPVITLPVHTKFSVGLFSDNDKTRFKRISGELQPFYLASGFFPQSGAASLILPGPGLHKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Z3</accession>
    <name>A0A158Q4Z3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1014</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Z3"/>
    <dbReference type="STRING" id="318479.A0A158Q4Z3"/>
    <dbReference type="WBParaSite" id="DME_0000607501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000607501-mRNA-1"/>
        <property type="gene ID" value="DME_0000607501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000607501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31756" checksum="73855F287D65CC1E" modified="2016-06-08" version="1">CRELIELLKDERKFIVKAIASEEIVISNVALSVMKMVREESVRYKLGNEEFSPYESLRKLGNAITFSNEIPAKELKKSVLAAMHEYSTEIETCRGNMIGQARNYIGRADTVLTHSLTSSATLKAFFETANKFKRFRVFCTEEGISYAEYIQPESLLMCIEHTTRVVLSAAAVFLDGSCFAVPGSLTICRAAKLRSVPVFFCAAFYKITPILPHTYNAEPVGSPKTVLPFTFSKTYCYSQVINPVFDFIPAELVTSYICHTSIIVPQHVRRVLGDYYHPEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5L0</accession>
    <name>A0A158Q5L0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Piezo-type mechanosensitive ion channel component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10101</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5L0"/>
    <dbReference type="STRING" id="318479.A0A158Q5L0"/>
    <dbReference type="WBParaSite" id="DME_0000766701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000766701-mRNA-1"/>
        <property type="gene ID" value="DME_0000766701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1234"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1410"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1452"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1579"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1847"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="14">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="12">
        <location>
            <begin position="522"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="15">
        <location>
            <begin position="1485"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="11">
        <location>
            <begin position="1640"/>
            <end position="1934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000766701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1937" mass="222828" checksum="3764A6AB5E7946FA" modified="2016-06-08" version="1">MVGNWQGYNNENRRQCFPRNRILSIFMFTNFTYDRKSSTSVDRCTNAKTSIPLWRRTLYPFWLLMIGFSMFVVSAIYTYQFYKLPQLYQKYFGFSEDLLRSFGLEQFSNGELFLRLLSPIIFLVFALIQVNFFHPFLIEQTEKWEKAYYHSKSGLLSVFEKLNLSLPAASAMRNDYFNETASNNKWNGGSIQEQEHSLIKSNFGSQAFLKQIGSSFLCFKSSMREFFWRVLEIHVDKVVAFAILLISLHENTSAVEKNTHDVKESISSLEWIGLSKIDSLARHCLIYILLALLMAFRSIVHIRRSLHRYIYGEIDCTIGVLFSNISRKDADTNVLNCLKYFANFAFFHFGCEICLVTAVITIGVRCDAISVYYALLVLLISVLLIKNRSLLCHLWPYMTLSIAILFVWQYLICVGMPKMFCVAYPWSNWDINMIEWLFLPDFFIQPNPVKLYADFFLLLFISCQFCVFETEKHEREQIRKRFSHELYLGHKKEIHVPDFIANEKFSKCSFREILSIAEMKNENFSLRDSALNLLKRILFMHFYWITLGVIFIAGTTRVTFFALGYVIGCFFFLWVGNSIFLRPIRFALAQLNKLILYNASVILFKISLQVVGCVYMSQMYKNYCWVLQLLGIACLKTGIMPEKSLGLFCFTLTAPLIKKFAVLVPSILAECNVPHREAGIYYDGICFTFLLIQRRIFSSKYFEHVVAEIKAQKFFSSRGAEIIENITKKETEEALRSEREALIIVREKMENIRTKHITGSDINLPVIYSNDHEETWDSKETFGPSDSSLQNISIAPNTKISTEVSSKTYGTINDNAESRRADFILKNRKRCLSLSGIEEDAREVAENWANSVENSVDSKIRENEGGIKGFGPLQLLNYAFKKGAIKEALKESEVIKATHAKMEQEMEDAFGIADHNAIRKAILRNKERRPKADFDEQTFDESAITHKQTLDARLMSAHSKIPRARLSAKRSLLLPSSVLFEIANSDFPVQSDSQRKFSMDYKLRYGAPESSSNTFKGAIDALAVIKLRSTDEVCIEAFIEIITGVLDHLFEFFHSLKTFALLFGDGVLESIIENLMRLSRDYRYVAYILTTEKGIHKEMSVRIKGERELRQSIRKRRSSLLRYSFSAASKMKPDKSMIQLHEYMKGMENEQDRDEMDLTRCSISPAKANVEKHKASRLIRLIHALYYALISKSEMICYFVIVLNHMNSASLLSLPLPLMTFLWGTLTVPRPSRHFWITLITYVQATVIIKYIAQFGFFPWNKTASSVNPFYPPRILGIEKRDKYATWDLILLMSIGLWDHEEEIKKRSVSEKRPKKAESQIIQSKFSASLKESSLPDICEEDQERMSRRFTFSWSIFARRSVVKRYASNLCPTELIIRHIKLRIISIRNFLHILLNPVDRCPLDLYAPMFLCDAVCFLIIIFGYSAFGVNVIHTDSGGVDGGVTAYFEENKVPATLVSMLIIQFVLIILDRAIFLRKFLLGKVVLQIQAGYHNRSLGNIITNSYSLINWLLYKAFLLIPFLFELRALMDWMWIDTSLGVGDWFTLNDIYAHVYMIKCERKIEEDYPSPKGVKKRPILKYGLGGFLLVGIVLIIWFPLVIFSMANTVGTRNLPIECTCKLTIGGYEPLFHSTAQHGDIHELSAIEYEDLQYIYRMNKVALSYMADYDHLDVVKASINGNSYSLWNISPPSKGALIEDLNGSLPMTLKFEWYFKRAPNENLQFGVVESSRTININAGDQVRKDLAEVIATGSNKSIYIPNLLVPLVKVPGEGKADYVHALLNEHLQSKDKPIDSVFYDALLQLDSADVGQWWQLRMIDPCFDPLLKRDPIVLDHILIYGFVDKVFPVTFSIITGGGILSLYLSMVLVFGRLLRSLVTGAMQRIMFEELPNVDRILRLCLDINLVREAGELQLEEDLFAKLIFLFRSPATLIKWTKEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6E1</accession>
    <name>A0A158Q6E1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3422</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000132">
        <property type="protein sequence ID" value="VDN53449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6E1"/>
    <dbReference type="STRING" id="318479.A0A158Q6E1"/>
    <dbReference type="WBParaSite" id="DME_0000983901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000983901-mRNA-1"/>
        <property type="gene ID" value="DME_0000983901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="632"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="1">
        <location>
            <begin position="818"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000983901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1295" mass="146521" checksum="217FD1837146CE3D" modified="2016-06-08" version="1">MLEERIKEGFGPLIAILTSDAVETIIAKNKLTFAELLLPFRIINCTLKDPSGQSTTSRIHFDFRDLRRDGFLLSLTVLPSVLHEAVSAVASTSDTELAATVLCESLLHWAEPTEYEFLHTYLACMFVISSNDSDPMNELAKLVHMQHSQQHGGSTNAVGPAHCVPPKWLLPNIYKFYVLLHDLSADNDSRFFCKIQTNELFSSMCSTYGVQNCHLLRINSGKNVGLPDIWENILEKRYRGLQNGLILARKNVLSKSGVATDIAQNSYKSVDLMNSLDNTHSEKSLRGQFLTVEDRENITKFVDSMFKTGLIPFFERQISILNEQITARRGISKSFATGMRKWFGTTSQPSLGSNITYSMESTEMQTRRLADLSFIFGLYSYAYQVYQNIKKEFAVDQAWLYHAGALEMTAISAFLNTPQITAKQYPAHYMDNAIGYYSNCGRSVEIIRAALLSTLILTSLEMYVESATQLLKLTVLENDLYSGILLERASNCFGMAKMIRKMAFHYVLAGHRLHKAGQKSLSLECYRRALPEYAGKNWQFAEDHILYTLVNENKQSSETFALCERLIRAESQQNAEQQQLFLKAYISLLIQQSNLHKIMPTVKIPLVNMQNIATIYGNVPLILPPEVEHGNDQFWKELEQNAFQIIAEESDIFRPSPTVSCSATNNAKIHFTPPYEKFRVFIELKNPLEVPLQIKQAHLDVKGHLACFQQNFIDTVSSLSIILDAHSDWTVFEFFVFPNDKLNELTVCGLIFDLFLDGLSVTCQIPLVIRGPRLYSTKKQITSVIYGVDHRLKAHVSTDQWPLLNIEMPLPKYIDLFCGQFYRFNCTFTNTGSVPVKNISLVTNQAECLSIFEEVQDGDNINRWKLAWCTTSKNNKNVLIFKLQNSVTAVGESRRLKVALRAPQIDTDAFNVCLLFYYRGINGLFREERFSTMLKAKKLLKVSLRLIDLAEGSYVLNLKNDTSLESVLVKVELLRLRLAQNFHSNNGPMSAQFRLFSSTSRSEYLFHFINVSVKLDCGQCENFCFRAVNDVSLMHSPANSHLPFTSSSMDLWLSSPVSDLPEWPVSPLKISDAWNKPDEQKSLQLFNLGLLWKANIVNTDGLVSNVFGESFIENSFISDYSTVNEEISRTECVSPLLCSVSTESDIILHDFSVKRLCQIPVQIMISNRDIDCRNCDVVLEYITPSDSFRLPRINSAETRLHLSSASQPLPSTAFLQRSSISQPLIVANRSVFRARILYGHTHIFRVKLSVPCASVYSISCFRANARFDNSETVVPIVIPNGYVTVIMNGSNRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6L5</accession>
    <name>A0A158Q6L5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein DPF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS3879</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the requiem/DPF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000207">
        <property type="protein sequence ID" value="VDN53906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6L5"/>
    <dbReference type="STRING" id="318479.A0A158Q6L5"/>
    <dbReference type="WBParaSite" id="DME_0001041801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001041801-mRNA-1"/>
        <property type="gene ID" value="DME_0001041801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="359"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN53906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0001041801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47722" checksum="C63EBE0D159189CA" modified="2016-06-08" version="1">MIDEARYIEAIINCSKWNGRNEKERKSRYPMIEPQTGVFQRPTSHLYRNETERYPPHLPTYYCTYSRKRWKRKKNAPSSDATEMKYIVQCNPAISEVINQATAISTEASGSNEAFSSSDFCQSVDRRGRQTLSYQSFHHLCIFLRFKLEKQLEKNKLKELLENDLEEPSEEEVVDMSDEDDWSEPRKKRKKRGGAVASSGGRGGSRRGTTSNVTIVCQPISSDPKAFACNNCGAKYRSRPGLTYHRAHVHPDVTNSSDVSQLSNYIDSLRMNIGFPLVEIINSSETGHPFLLSVLSSTIEISTTCDLCLGDRNENKKTNTPEELVSCHDCGRSGHPTCLKFTENMLISTRRYGWQCIECKSCAICGFSDNDDQLLFCDDCDRGFHLYCLRPPLSQAPEGEWSCYLCQREFGPKASLPTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P5R6</accession>
    <name>A0A3P7P5R6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P5R6"/>
    <dbReference type="STRING" id="318479.A0A3P7P5R6"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000158">
        <property type="entry name" value="dnaJ homolog subfamily C member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="231" mass="26979" checksum="3FA5C9013B3ADA8C" modified="2019-02-13" version="1">MKETEKKDAVLTSKQQIDRLLRPGSTYLNLNPFEVLQIDPDSDVDVAKKKYKKLSLLIHPDKNADDRDRSERAFDIVKKAMKMIEDPDELAKCRETYAEARARLAVIMSEKRRKQKKNGLGDKIPEDDPDAYNKALWIVVTKVFADREKKRKMLEERANDEKRRAAEELHAAAEKRKREEEFAKNYEESRDERRGTWRQFMAKKAKREGEGKSLRGTAFRPPKIKLETSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PHZ1</accession>
    <name>A0A3P7PHZ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PHZ1"/>
    <dbReference type="OrthoDB" id="5776623at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="309" mass="35348" checksum="AD4E3893504CBA46" modified="2019-02-13" version="1">MARKVIISSSRLILFSNLFKTINIFSGKLFRRDQLSVVVVNCGGCDTSAFVCKLLKCAGSEVRVDLMAKSFSFETAGVWRTINLIEVDSAKHDLWMSLNVDGCLLLFTPSSNHSFKQASEKLRKRKSQCNCDDLYNWQIWHRRPARQWVTPSSLCRRKRERFNTNICFCHHITVLLKHYADRIWLIGVANDPASSRRFSSSVSYNGFALIFFSSEHHFPQNFLITPPMVEARGVAQSVGAHYTEVVRDGKTERSPLAYNYLMTDMMSFIGERKVECMPMKITFEFDGKDTSEANLIVRKNVNALDFAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PP49</accession>
    <name>A0A3P7PP49_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PP49"/>
    <dbReference type="STRING" id="318479.A0A3P7PP49"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="289" mass="33133" checksum="278A85121AF06867" modified="2019-02-13" version="1">MRHVWSYVVRYENNSSEISCCVKYTIFGFNVIFWIVGFTLLAIGMWAHHEKNTAYSHLNKVSKFYLDPAMFLIFAGTFLIFLIGFSGCVGALRENTCFLAFYSAIIGLLLLAEMALVVLIFASKDWFTQELFLRLDDTVVMYRDDPDLQALIDWVQIYFKCCGMRSPNDWDMNIYFNKSSQEFLSPEAGGVPYSCCKKLSLDNGPINYFCGHGARLIKEVLFYCLLQGVSDSIHNEGCTPKIENYLIQNMTYVAVAVVVVAVVQILGILFAQNLRSDIFAQRARWFYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PTY0</accession>
    <name>A0A3P7PTY0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dendritic cell-specific transmembrane protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PTY0"/>
    <dbReference type="STRING" id="318479.A0A3P7PTY0"/>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="354"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="611" mass="70764" checksum="5C9A62B56A95081A" modified="2019-02-13" version="1">MFEMSFLSLYEQKRKALEKLRQFKLIADNCDREATGKPLLVDRRREFRKKVEKIFPFLRKPPIPSSTNTYERLFEAGTKENDIFRLVLTIIICEIVGILFCITIAVKYSTFPSVLGIYAGIGTQIVLGFMIVSPTIRAVILLAIPKLVTSKLRAIFLLFLISWSFQFPAMNTVENLQSLAISIACIRSSVIQVGNDIIEETNQQLNKIRLIFIEYLLNIYKLAQLMLIKEMCQRFFIGPYYFVRNFYSSLFFWRSLCMKTFEEASVKCDEHMISFTNKICSYIKDLKAVCAVARFTEQVCVIPDKIKNTLKLGFLSFIKDKAQNTVKSALDALNVTFYVALKYAVKYNNDEKTDNFYITDEFRKIDLLREARNEPAILPLLPEEEKKYLDGFKLHMLAKEKLKLTFSLGMTLITGFVPFLLVMIDVFTYELLNYSYEFFQSNLTQTDRLDHYELAISGEGFAANLMKKILQIFNPITRGSDIYASRLRRIIANHYWPERSKPRALFLYNQLLLARKLLLSDVIKRAKKKEFKEQLAHDEMAGRSNLINRGLPIIRGDEDQCIRCGCFNLSAIAASNSRMCPNCDGLYCTDCYAVRKRCLKCHTNMKNSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXS8</accession>
    <name>A0A3P7PXS8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXS8"/>
    <dbReference type="STRING" id="318479.A0A3P7PXS8"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="662" mass="77539" checksum="5B3CFD852FCBFE19" modified="2019-02-13" version="1">MKDIGIIRNLQYQILMLVFRKPKKYILAMFPYTSGKLHMGHLRVYTVSDVLARYYRLKGFNVIHPIGWDAFGLPAENAARERGVDPKEWTYSNMEEMKKQFQLAGIQFDWDREIATCSPDYYRWTQWIFCRLFDHGLLRRSVSEVNWDPVDLTVLADEEVNEGRSWRSGVLVKKRKLKQWLVETPKYAKRLHQGLNEMSHWKYVAEIQANWIGKCDVWRFLLPLKVSNCKIYLLDEKVFNIATRRWIPIICISDYDDSDNEFFLDARFASQKSEFDIKITQKHGIDIINTEKLLLSNEDIIEIAKEGNYGGYETSRILKDWVISRQRKWGTPIPVILSEDSQLAVIARDDQLPVNQLGKKVHCERLPSGYGYWESDTLDTFFDSSWYYLRLYLDPKNEKEILNKKNLRQMPVDIYIGGLEHAAVHMFFARFVCHFLHDIGIIHTKEPFDILLTLGIVRGRTFVRVDNGQYVQEKDVLNSGSVFLDKHDNGPLIKRFEKMSKSKYNGVNPVDLLECHGVDLTRLQLLYAASPKTQIDWDDSEENTSSFYNFIIDYHKFFSYYGKFSKKFKYSTMGANEIIFKAFTPNLAAELWAAVSVITEQCWPELDKDADVYFVIEVGLSAVLTLCFDDKLTDDLLMEMLSNIERMKRSNRKKILLNKYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q5T7</accession>
    <name>A0A3P7Q5T7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q5T7"/>
    <dbReference type="STRING" id="318479.A0A3P7Q5T7"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="227" mass="25518" checksum="631F0962F5DA59EF" modified="2019-02-13" version="1">MWFFLLKKVFLYDKIAISDDFVSSSKLNIDVLDVKPSNILVNGRGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGNYYNVQSDVWSFGLSLVEISVGRYPIPAPTASEFSIIFNIPEEEIEFPGGILPVAPSSTPSTPRTMAIFELLDYIVNEPPPVLPLKIFSDDFVDFVSKCVKKNPMERANLKILSNHSFYKIYSNSEDGGEFARFIREVTESSRMYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q873</accession>
    <name>A0A3P7Q873_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q873"/>
    <dbReference type="STRING" id="318479.A0A3P7Q873"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="445" mass="51920" checksum="96B6D476279778CC" modified="2019-02-13" version="1">MLCDKDYDPVTFDVLKVKFTDFASQITIVDVALFKAISAQELKSCAWTGKIKHVAAPNIIKFTGRFNSICLWCQREVLLCKNLSKRAQIIEHFILIANVINDNFFCFFLTFMQSQLPQLTNMNNLHSTFAIFSALQSQPIHRLSKTWNLVARRYRLLLLKMSHLFDSERNWEHLRSYLDNVSLPCIPYLGIFLTDLSFVEVAHKNSCLELGSVEHKKDENIILVPCIQKYLDTFRFHEELSKLVEDDLYKESLLREPASFPVECFSSRQSRSSSLTRKLTRVSRFLNHNICDISHRSQTSTPRLKHFDRRSRLSLQPHQNLIGSLELDRPLKVADEDKDALLEGEIGMRPDYEGEVKRAIVRIRGSKQAMIHCIQKCYLELRSNILHQFHRRTVTVQCKHARDLYKRNASKLMTIGQDDWRIIRNRNVEEPSFELHHPTTGILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QXU7</accession>
    <name>A0A3P7QXU7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QXU7"/>
    <dbReference type="STRING" id="318479.A0A3P7QXU7"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38199" checksum="6ED724FF11321C17" modified="2019-02-13" version="1">MLLSESKFIGIIISMNFFVPRTGSYGRVFLAKDCRSDKYFALKKMQIKKLVQMRQTTHVHSEKNILEILSHPFIVKLYKSSIDKANLNMVFEYIPGGELFSYLRNVRRFSNSITRFYCSEIVLALEYLHSLNIAYRDLKPENLMLDHNGHIKMTDFGFAKVITERTWTMCGTVEYLAPEVFTHQGHGKAVDWWSLGILIYEMMVGVPPFQGRNVNEIFDNIRSGKLRFTRTFDFLAKDLVKKLLHTDQHQRLGNLKNGAKDVMNHKWFSDIAWTDLIERKIPPPIKPSISSNGDTTNFEAYEEDDSEEVVRIYLFAFLEIYLVIITKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SQX6</accession>
    <name>A0A3P7SQX6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab5 GDP/GTP exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SQX6"/>
    <dbReference type="STRING" id="318479.A0A3P7SQX6"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="5">
        <location>
            <begin position="186"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51877" checksum="53D94B691ADBD5BA" modified="2019-02-13" version="1">MQLCVNGCGFYGTPQWKGRCSKCWRAYQIAQKKSEDFTKNRELLNFEKFEERRKLSTESRSLTLKNILRRSSIPNGSDFQAFNSFFSKRHLSEESRLARDEFYNYLNHNLPPPIAYEILRNTRHAVAKIAEHLSMDDLSSLVLHFYQVMTEKLQYSRYFKEIVEKIEHYICVRCYVILFCAVADEEVADLSLQDRIRSLNWVTSGFLETNLDFSQQSVQEKLDEAITEMIDINSHRGAGEKLNCLVRCSKLIFEALKESRSASADEYLPVLIYVLLKGNPPLIQSNVKFISRFALPSRIMSGESGYYFTNLSCALQFIQNMNADSLKMPQKEFEAYTCGQQVPPLSSLNMGCNQLSFLVGNLWCNSYRESDKFLREIHDCCDEYPSAELQSLSKQIAAEESQMSTSCSLISLSVNSSRTTSRDQDLEEGCSNSLDDDLSMSCQLYLLKSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0K1</accession>
    <name>A0A0N4U0K1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4445</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0K1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0K1"/>
    <dbReference type="WBParaSite" id="DME_0000008501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000008501-mRNA-1"/>
        <property type="gene ID" value="DME_0000008501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000074">
        <property type="entry name" value="SHaW family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF234">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000008501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="52439" checksum="8A39240D4B24BC30" modified="2015-12-09" version="1">MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLTTFGTTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSLDQVIYFAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0K9</accession>
    <name>A0A0N4U0K9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS4453</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0K9"/>
    <dbReference type="STRING" id="318479.A0A0N4U0K9"/>
    <dbReference type="WBParaSite" id="DME_0000009301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000009301-mRNA-1"/>
        <property type="gene ID" value="DME_0000009301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6147412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000024">
        <property type="entry name" value="ACXA, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000032">
        <property type="entry name" value="Adenylyl cyclase 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="247"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="689"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN54480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000009301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="887" mass="100745" checksum="80A24C11220C6891" modified="2016-06-08" version="2">MSLSSQIIATPSQTTHREIRQILSRHWRAIDRARLHTFHLWLLLFSITQIAIFNYIIPKVLLHWSIACFILAIFFIIYIIFSSITIRYVEEVNFKSFFSYYLNDGRIPSLSALCSGLCMTTIFQFFILPRHRRLFFIISVAWNISHIVLVAFFLYQATLSIIGSIADSSEAGNRAEIAMKLSEAVHRRTQLESLKARQDQLLLSLIPAYLTDKVSKAIVASSSDNGKNSKNHKLFHDLHVQVHNNVSILFADIVNFTVLAAQLNAKELVRTLNELYSKFDCDAQKLQCMRIKFLGDCYYCVSGMPVNRPNHADMCVVMGLEMIKTIKQVRDATGVDVNMRIGVHTGSVLCGVLGLRKWQFDIWSDDVTLANHMESSGIAGAVHITKATKESLLGEYNIVEAYSNDPTLVALGLPTYHILPDEKTAPQRTASIYKIIGYDKMTKFSKNGFTRLSMKSKVSKMAEVWGAEAPFVGMPKRISPQAESESPQVKDLARRPQYLNTVQSMTLIENNLANFSLRNFFCVAKKLKNFFSSKSVICGLSDCIVLFFLHILLRCIVHLSTVFVLNRLPYASRCFFVAADFTVFILILCLFSSTQNSPQTTGYTLTVICVDMIFTFLLLLFIDWIINYERKVEAACNVSFKNEEREVTTMQDINKLLIENILPSNVAVKFLDSNRFVDDIYARGHDNVCVMFASIPNFKDFWSEWGTSRKLECLRLLNEIICEFDKLLSKPKFSCIEKIKTVASTYMAASGLNEQENFDDYAFRNASIMVEFAMAMNSILDQLNRDSFQNFELRIGMSCGPLVAGVIGAQKPQYDIWGNTVNLASRMDSYGEPRKIHMTNEMAKILRKGCYVMQSRGMMRVKGVLEPIETFFLELDSKRNSAISLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M3</accession>
    <name>A0A0N4U0M3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4469</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0M3"/>
    <dbReference type="STRING" id="318479.A0A0N4U0M3"/>
    <dbReference type="WBParaSite" id="DME_0000010901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000010901-mRNA-1"/>
        <property type="gene ID" value="DME_0000010901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF91">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="550"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000010901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="889" mass="100372" checksum="8999F2F681FB338B" modified="2015-12-09" version="1">MEASFNLRFDSFLSLQLAGELDANIYTAISRQTAFSHIERLYDEAVLKLKDDEEQAYQLFSRMGNIAKLIIRKNDFIHFKNTPNGRRFYDLFKICISHMKNLEESLERRYGVLKIAEEDCMENAKENLAEFETNKKDSGSANDSTSDFVSKLLIAPRELIRFVEEKHQVLVIDYREDQSTMLKYDKCDRILVAHVPANAIVPGCIGSSLIKSVAIGERALLQRMSDVDLVVLMGCGSADLRDDNIPAGSKEQILYNALLTYNNIFCLRRPPVFLQGGFENWRLYYPMYASSKVGIRKRSLDINDQSEFARAVAQYKKDIGVQSLQYPDLLLSVKRKLVQQPHDGLSAAPRNIPSQRPKLSSTLSSENEFNLPAVKNVNISLLDSKENQSKKIMPVALKVLESVSGQQETKILHSQHDSCCDTGSTCAVDLSVLSNVHTDYVPLDKNSVIAKLNSTGAENSSSDVQEKPTDFTSPEQAVPQNSPQVVAGAKIDENFSPKSVKERPIVPDRSFKPSVMPSDYPKCLFVLYDSMIDLIKLESIRGSVTLPGFTGLINLGNTCFMNATLQALFNTSALRDIFTKEHFVSYVNRSNEMGTYGVISAAFSALLDSVWSGLFAAITPQQFLESFANEVNSALANREQHDPQEFLIYLLDALHEDTNRVKKRISFEQNYDGSNLIAEAADYAKKSKQFWSSPVTDIFGCRTVSHLICNTCQMQSVTFEEMTQLSLEIPKKRGATILQCIEMHFDPVILSGSCKWLCPRCERLRVATRSSKIWKMPKILIIQLKRFTFVDDQWEKDNTLIRFDTTPLDISSLLHPSLKELSRSESGYYGLYAVTNHAGRLHHGHCTTIAQNNCTMDWLLFDDEHVSRLSFESVCSKDAYILYYKKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N1</accession>
    <name>A0A0N4U0N1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4477</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0N1"/>
    <dbReference type="WBParaSite" id="DME_0000011701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011701-mRNA-1"/>
        <property type="gene ID" value="DME_0000011701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875984at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF428">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="34737" checksum="8F69EB6600B23A4C" modified="2015-12-09" version="1">MTKIFINFQQCAAQLHECIPRPRNCKVGAKGPPGERGIDGVRSLFHDYVKIILEPGEPGKNGEDGIPMNDWLENEERCFITCPMGPQGPPGADGPRGLPGSDGEAGEPGSAGLIGLPGLPGQSGDPGPCGNREPGAPGEVGLPGIPGIKYYYLPGPKGPTGLRGRRGPPGTPGKVGKLGATGKMGTPGESGPKGLSGEVGPFGLAGPVGPPGDDGGYCSCPKFAPLIDQYNQVQSYNRPKAKGASNGWYAINPKSNTENYQNIPAIKFGNEYFETHNDEQEWENYEVNSNSNSREDIPSEPKQSPAYVKDIDDYNDQIIRRWHSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U122</accession>
    <name>A0A0N4U122_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAGA-associated factor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4637</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U122"/>
    <dbReference type="WBParaSite" id="DME_0000027701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000027701-mRNA-1"/>
        <property type="gene ID" value="DME_0000027701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000027701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13998" checksum="DF4FAAE59042E3F9" modified="2015-12-09" version="1">MFIDEEVHQQKFYALANPPNLTNEKLECFKCKREVITCQYAYHLAECMGNEMDRVSRFSLSASSCNKDDKRQNLSRQNFDRPFTEIISSELNAACAKIRSFPENTTHISGILSKALFGSCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U191</accession>
    <name>A0A0N4U191_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4716</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U191"/>
    <dbReference type="WBParaSite" id="DME_0000035601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000035601-mRNA-1"/>
        <property type="gene ID" value="DME_0000035601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855340at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1940:FF:000002">
        <property type="entry name" value="PHAryngeal gland Toxin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF5">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000035601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13200" checksum="017942D90511958B" modified="2015-12-09" version="1">MNILACTTNVCLTGFTCLTVDNAGRECTCVNIATNCIQLAYLCNDRLYSSLMTQRCPQTCNRCNASAEMLSALIKISATLPCVDLARPNAVSDCPANKNLCQNSLYINVMREQCRKTCGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1J3</accession>
    <name>A0A0N4U1J3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4839</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1J3"/>
    <dbReference type="STRING" id="318479.A0A0N4U1J3"/>
    <dbReference type="WBParaSite" id="DME_0000047901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000047901-mRNA-1"/>
        <property type="gene ID" value="DME_0000047901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000047901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8627" checksum="14D68167EA83AB20" modified="2015-12-09" version="1">MSLEICSCYDKVRKVTNAIKEKMMDYNPYIGERQDRPVFVRFNDDPKEIVGGMRVVEIDSPRPTWFKSIVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1S6</accession>
    <name>A0A0N4U1S6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS4936</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1S6"/>
    <dbReference type="STRING" id="318479.A0A0N4U1S6"/>
    <dbReference type="WBParaSite" id="DME_0000057601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000057601-mRNA-1"/>
        <property type="gene ID" value="DME_0000057601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="19">
        <location>
            <begin position="11"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="20">
        <location>
            <begin position="539"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN54963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000057601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="758" mass="85654" checksum="A98918B6095DB7F3" modified="2015-12-09" version="1">MSNKSIAITSLLIFVILSLAWIVGFASRLFAIVRFESIIHEFDPWFNFRATHYMVENGFYKFLNWFDERAWYPLGRIVGGTVYPGLMLTSGFIHYALSLLNISIHIRDICVFLAPTFSGLTAIATYLLAKELWSTGAGLFAACFIAISPGYTSRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSVFWASLTALSYFYMVSAWGGYVFIINLVPLHTFVLILIGRYTSKLYVAYSTFYILGQVMAMQVPFVGFQPVKTSEHMAAAGVFGLLQVIALLKYAQRRITRNQFMTLFVGGISTVVIVGFTAVVFLTYAGYIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHITAAVFPVGLWYCVKNINDERVFIILYAVTAVYFAGVMVRLMLTLTPVVCVLSGIAFSYTYEKFLVDESEEPKSGMDEEESKHLYDKAGKGRKGGSWVNQATTESDNGSIGMNARSVVSVVLVLMLLMFVVHCTYVTSNAYSHPSVVLQSHTSDGGRVIMDDFREAYYWLRKNTDDNARIMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSNESAAFEIMNELDVDYVLVIFGGVIGFSGDDINKFLWMVRIAEGEHPKDIRESNYFTESGDYSVGEQASNIMLNCLMYKMSYYRFGDIRFSLGHQQPAGFDRTRGYVIGKRDIVLEHLEEAYTSENWLVRIYKVKKLPNRPSIKYQQRKIKSKSSTYSKKDKSKKGVIRGKLSIVKARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U209</accession>
    <name>A0A0N4U209_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5041</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U209"/>
    <dbReference type="STRING" id="318479.A0A0N4U209"/>
    <dbReference type="WBParaSite" id="DME_0000068101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000068101-mRNA-1"/>
        <property type="gene ID" value="DME_0000068101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="448"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000068101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="836" mass="94027" checksum="9F28BD9EC45E1A15" modified="2015-12-09" version="1">MVDSPILPREGMSAFGSMDGLYNGRRLFTAPNNGAVLVSGDYLQSPSVTKQNANILPFSTENFENFQNQHPSFARKASNSSTNNNSNANCTIENSPYVHQVPIRIVPEICRNYQKTLPHLVPYSINIPIVKHESISRSSHKASIEIHSKNEGEITNTCNFNASPSVVEPTVCTQNPVAHSNDYSKIDPSKHSISNETVSLSQLINSVSTGDRVVWFDASNIPRRGTVRWIGHLHGHSNIYVGVDFDEAVGGGTGRYEGVQLFRTALNHAGFLPLLVCIKESDLDDGSQGQSFRPMISQSFSDTLISQSNSLNRDVNANEKLLQSPFTVGSCVEVDFRGEKRFGVVKWIGRSSDEDCAVDEKIAAVEVENDLPLDWQSVSSNQQILFTTSNEFHQLNDIIVMVPISALRPDNRFATPIIGEAADGLGETAGKFFLSPTRMIENLVGRMKGIQGYRNSCYLDATLYAMFVQCNAFDSLLEKSEAIRNDELRCELVRILSTEIVYPLRRFHFVRADHVLNLRQLLERLLPEMRGLTSDEKDPEEFLAALFKKLLFVKPFLIMRNLADGKTDLAHICPLITEDLWSCEQRYIISVQSLLERSLFASNIQFAKDPKILILQLPRYGQQKVFDKIIPQQELDITHLVYDQRRPCATCGKLADLMCPECFLTKEVLLSEVTYCGLCYEKAHVGYDHRSQLLDSLSERGGLLSLTEHALSLTRRSQIAQRKLQLSAVLCIETSHYVSFVRSPSNKWFLFDSMADRVGLSDGYNIPQVKQCDKISSWLCESGWPKLQSFVSRERHLPSEVENDPSLLRLLSDCYICIYISDEKKNDGMNLSKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U224</accession>
    <name>A0A0N4U224_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5058</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U224"/>
    <dbReference type="WBParaSite" id="DME_0000069801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000069801-mRNA-1"/>
        <property type="gene ID" value="DME_0000069801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10643822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000069801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29250" checksum="E484EDAC9D08078D" modified="2015-12-09" version="1">MPGLDTYRMYHGAENNEKNIDGNFLSSTERNENSNSMERQLTVSDINRLIDRKIEQIFHPDSSLVKNIAKKVDEILKSLLFKKDFDENKRVDFSLDSPQDEITSKRIGLDQLIEQKILSFMKLDSKRILDQTTATTTSSVMKSGNCKTIREVFRPEGRSLLVRAMKDAAEDWNIALSSSFTILADRIQALINESNDFRRHLYDAKYLLEGFMGKNSIRNEKVRPINIKDWGTISDLLRCANNKEYQFIELVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U289</accession>
    <name>A0A0N4U289_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TAFII55_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5136</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U289"/>
    <dbReference type="STRING" id="318479.A0A0N4U289"/>
    <dbReference type="WBParaSite" id="DME_0000077601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000077601-mRNA-1"/>
        <property type="gene ID" value="DME_0000077601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="6">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000077601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22483" checksum="2EB33F0498684C88" modified="2015-12-09" version="1">MSAGSSKILAKRVPQRVVDVAEEVQDWENYIIVRFPDDVAQKVAKMVDEGGCEELAIKFDTEMRNATVRFGEQLMPTKIYDLPCIIEVMKTIDKKNIYKVADAPQIMICSHDLQSVTTNSHSDETANLKRDKIYQWPHGLTPPMKNVRRRRFRKTKKKKYMDAPEVERELKRLLRADLEAHSVRYEVPFFINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2A2</accession>
    <name>A0A0N4U2A2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5153</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2A2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2A2"/>
    <dbReference type="WBParaSite" id="DME_0000079301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000079301-mRNA-1"/>
        <property type="gene ID" value="DME_0000079301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000079301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17695" checksum="1FAE8A95786D2504" modified="2015-12-09" version="1">MVPLGSLLITDKKALRTKVMGEAVHTSPTIGSNVEEVTWRNIHFIIWDIGGQESLRSSWSSYYVHTHFVIVVIDSCDINRLDVIKQQLFMMLAHEDLAKAAILILANKQDMKGALSAAQISSEMNLSSIKSHRWQIQACCALTGEGIDKGFEWIASNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2R2</accession>
    <name>A0A0N4U2R2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5343</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2R2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2R2"/>
    <dbReference type="WBParaSite" id="DME_0000098301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000098301-mRNA-1"/>
        <property type="gene ID" value="DME_0000098301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846929at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229742" description="Abnormal cell migration protein 18-like fibronectin type I domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000098301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39896" checksum="2CF43EF11269EECF" modified="2015-12-09" version="1">MIFHAIVLILLTNPVQRADGLRMPLKIPVEIRFDDLDQFFMPMNCSHASFIPSAKLQDETWRRGHLLYKCGIFGAYKIIGCVTNENKTLKIGETFVEDNVAHQCFNKSGSVFYREIICGLLGQPDCDKLTFVSVQMNKFKLLTNLNSLKCTIFLTVDCHLITAYSILNNPIKAEINLPAIDQRKEIPGLYSIVVPTGWKIVDSNGNLLPISHIKISDGKIVVGLAPSIIKSFLSRARKDFSKDFRRLQEAKLYAARKRRQVNFDASIPPRSINAKLTLEPLPNQRIVGIGTGSVSLDERQPISSDGTRNYKPATVTGSRSDVNWSGKTMTVNGKRIAVGPGTFTFGNSPQGPIFKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U379</accession>
    <name>A0A0N4U379_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 17">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS5533</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 17"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U379"/>
    <dbReference type="STRING" id="318479.A0A0N4U379"/>
    <dbReference type="WBParaSite" id="DME_0000117301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000117301-mRNA-1"/>
        <property type="gene ID" value="DME_0000117301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF65">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="527"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="16">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN55560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000117301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="73188" checksum="B2B3487E1523A656" modified="2015-12-09" version="1">MAQLLIIWFNLENLDEKRLFIEAELETFKRKRDNLQIKIWNLQKDIHRMEKYLSKINNLIRDRLLMTENPNNLPVIYFITPTYYRPTQKADLTRLVQTLVHVPNLVWIVVEDAREKSQSVANIIQRSRIQSSHLFMLTPANKKLNETDPNWKLPRGVLQRNAALSWLRTNFGSLKQGVVYFGDDDNAYDLRLFEEMRQIKKVGVWPVGIVGGLLVETPIVDESNNSKKVSSFNSVWKPERPFPIDMAAFAVNLSLVNIHKSAMFSYDVPRGYQESHFLRSLDLQVSDLEPRANFCQSVYVWHTRTGKVKLTAKEREKFQNRSLSKLEKSSKHKTLNSYHGTHALRERAAKIKQGILIIRFEMPFNIWCLGCNNHIGMGVRYNAEKKKIGMYHTTPVYEFRMRCHLCENYFTIHTDPEVEHVEEDKGKGMSASNQIEKLEWIQERMRDDFTANQALRRNFRVEKKEMKDREIADDDLRKRTSLTINLLPETSEDKKLASLIRLHQPSKSYEEQREATRLAITNRSIFASSKKSSDQSTERISKKKNQIKIKDNNADAFSSPSSFQGPSSARKQLGIVIKSPSNPLTKSNFESQEVKTDISDHSTHADDIKNAKDQEEFASKKSLVDYSDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U388</accession>
    <name>A0A0N4U388_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5545</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U388"/>
    <dbReference type="STRING" id="318479.A0A0N4U388"/>
    <dbReference type="WBParaSite" id="DME_0000118501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000118501-mRNA-1"/>
        <property type="gene ID" value="DME_0000118501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000118501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30193" checksum="8952B7D6A3526574" modified="2015-12-09" version="1">MDSLKLKIAKLTKVHIDTGNIHRHKELFRRIFKDSVEELLAILEYELNYSKNNEKEFELKFENIIVLKHDSEYCQLANINKDDLKITLKVFMSEFDAKQVEESVELALKQLNIIESDSELRIWLEKVLPVWKQFEKLVSNRFVYALGVADLDIAQLKALYEAAEKVRPMIDHYNTEHCCTVPQELRDYAKEHDIQLLTHNDPHLEMLSEQVGKLVEPLFGEKSVLDLKWLARYSVWVRSRSVIGAKGYILQFMKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3K4</accession>
    <name>A0A0N4U3K4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS5671</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3K4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3K4"/>
    <dbReference type="WBParaSite" id="DME_0000131101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000131101-mRNA-1"/>
        <property type="gene ID" value="DME_0000131101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="62"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="243"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN55698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000131101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45900" checksum="D24ADA197B86942E" modified="2015-12-09" version="1">MATKKRKQIEPTVEDLSNVEFETSEEVDVVTAFDRMGLSAALLRGIYSYGFEKPSAIQQRAIKQIIKGRDVIAQAQSGTGKTATFSIAVLQSLDIALRETQALILSPTRELAVQIQKVVLALGDYLNVQCHACIGGTNVGEDMRKLDYGQHVVSGTPGRVFDMIRRRHLRTRSIKLLILDEADEMLNKGFKEQIYDIYRYLPPGAQVVLLSATLPHEILEMTSKFMTDPIRILVKRDELTLEGIKQFFVAVDREEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLAEKLKEANFTVSAMHGEMEQKDRDAIIKEFRSGSSRLLISTDVFARGLDIPQVSLVVNYDLPNNRELYIHRIGRSGRFGRKGVAINFVKSDDIRILRDIEQYYATQIDEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U463</accession>
    <name>A0A0N4U463_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5917</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U463"/>
    <dbReference type="STRING" id="318479.A0A0N4U463"/>
    <dbReference type="WBParaSite" id="DME_0000155701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000155701-mRNA-1"/>
        <property type="gene ID" value="DME_0000155701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000155701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14143" checksum="D9F102B26998645F" modified="2015-12-09" version="1">MLNDDESATADRLLAENIVVAAGFKTEFIKEIRRHGRKGTGRPRVLKIRLEDKHMAMSVLRNKDVRSIVPPGSFLRKDLTKRELLLDKQLRKECYTRNQSLNLKKYAVRNLQIVELRQSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U468</accession>
    <name>A0A0N4U468_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glyco_hydro_35 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5924</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U468"/>
    <dbReference type="STRING" id="318479.A0A0N4U468"/>
    <dbReference type="WBParaSite" id="DME_0000156401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000156401-mRNA-1"/>
        <property type="gene ID" value="DME_0000156401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="5">
        <location>
            <begin position="25"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="6">
        <location>
            <begin position="310"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="7">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000156401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64163" checksum="33B7B2670842F05D" modified="2015-12-09" version="1">MLIRGYKIIDIKISKQFVADQPFELGPYNCGEWENGGLPWWLILDKDIEMRTYDKRYITAVKMWFDVLLPKLVPYLRKNGGPVLMVQLENEYGSYYACDQNYTSWLSALIQSHFGKDIVQYTTDGPGDSYLKCGTIPGVYPTIDFGPSKIEEIDSYFAAQRRFANKGPLVNSEFYPGWIVLWGQTKQVIPPIMEFMESAIYMYKLGASFNYYMFAGGTNFGFWNGAEVAAPVITSYDFTAPISEAGDITPKYIAIRDWLETVSDWPNRPTDIPENNPKIGYGEVNLRRLTEISDHRAIAQFSRCIKSTYPKSFEDIHHPLGFVLYSTKLKIVGSNLTIPLIKDHGFTFLDGKLQEVFVNILGNYSKNWMIIKNAMIGSNLVILVENRGRQTYETINDFKGILSNVTLDGHILDDWVQCGITLKAIYRQLRRPGRNIFYRQLNRAKTIKNNEKNNPGVYVGTFKANPVVDTFFDPTGWGKGQVMINGFNIGRYWPSLGPQVTLYIPAPILRRNNIIILLELEYAGNCITNQCKINFIDHPVFNFTDNPYHVEQYMKKTIGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4X3</accession>
    <name>A0A0N4U4X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6224</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4X3"/>
    <dbReference type="WBParaSite" id="DME_0000186401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000186401-mRNA-1"/>
        <property type="gene ID" value="DME_0000186401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000186401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10934" checksum="E0B89FAC7AB22A07" modified="2015-12-09" version="1">MLRRRSVDSSALSRRTSRNYRQIIHGDSINVRNECKLEKHLSQPCVLQSSSTGQLKSRCEQNRSLLESWSKDNRDYVTRKLVMDATILMPIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5T6</accession>
    <name>A0A0N4U5T6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5T6"/>
    <dbReference type="STRING" id="318479.A0A0N4U5T6"/>
    <dbReference type="WBParaSite" id="DME_0000223501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000223501-mRNA-1"/>
        <property type="gene ID" value="DME_0000223501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000223501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33890" checksum="9D2AE54C53E98591" modified="2015-12-09" version="1">MADSSVQYVNILELKVNSNHELHQFQMCKKVGEILDELIPDSELRNVSGLIFLGNRLPEEMFLNEVKDLKAGYTVHLVISSFPEKKAELNLRKLKACRNELAQLAVWSWSDVRVASMQVYNKSNLQEIIINKFPSIRTDPVALIIATDLVLTLCYFSNEINDDFFIEHPLLVDAVHYILFFLFINESLKIDSSAVSFVDTFPVSSDAFQEESTYYDLLRSYGYVMNTSGHQVTWNLPNIFREAQQIIDAAELYADQNQMLVDFGFTDTERNLRILSQTNGNVEEALEIIVNEIQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U648</accession>
    <name>A0A0N4U648_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6733</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U648"/>
    <dbReference type="STRING" id="318479.A0A0N4U648"/>
    <dbReference type="WBParaSite" id="DME_0000237301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000237301-mRNA-1"/>
        <property type="gene ID" value="DME_0000237301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF59">
        <property type="entry name" value="ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000237301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37841" checksum="A0CAE3426F07173A" modified="2015-12-09" version="1">MFLILHRNLRSNRMNHIYVLLLHMNIADLIVTFEYLPKQIIHIYTIYWYGGDFLCKIGRFTDMFGVSLSSSVLICVCIDRQLSVSRPFSVIQGLQRNKTMLIVAWVTAVIISAPQLAIFIEATHPCNKAIIQCVARDYIGLLDTRIVLAYTFLTALYIYFIPLIVILFCCSIIHYRLKLSLNLESNGLGPLLSSTNLMDFHRVTNARLNNLRRAKAKTIRMTLGIVSFFLVCWTPYYIAVTIRFIDVNYKTGQLNKRIVLPAILFKILYMFAMLNSSFNAYVYGYFALNIKKELKSLKDFWFGSKQRFSEHQPYSSFIKKKISNSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U722</accession>
    <name>A0A0N4U722_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7123</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U722"/>
    <dbReference type="STRING" id="318479.A0A0N4U722"/>
    <dbReference type="WBParaSite" id="DME_0000276301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000276301-mRNA-1"/>
        <property type="gene ID" value="DME_0000276301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21494">
        <property type="entry name" value="PKC_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000276301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16036" checksum="CEB5C0DAF1B73F8E" modified="2015-12-09" version="1">MWLHACSIDPLEDFPETLLDFEGEDFFQNGEPRIIGIMTTLLEGETTCRIKLLRPELPLDLQPEDNSGLKCAVNVKETIEINGERRLVQKRKTAHPDWDKCWDIDVVPGRVLQIILMNGSNPIADATMRQQVIFSLSVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U740</accession>
    <name>A0A0N4U740_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS14</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U740"/>
    <dbReference type="WBParaSite" id="DME_0000278501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000278501-mRNA-1"/>
        <property type="gene ID" value="DME_0000278501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875488at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041614" evidence="2">
        <location>
            <begin position="20"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000278501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57790" checksum="1E41CBBAA4B32DB5" modified="2015-12-09" version="1">MAIFTSIFLINSLTALLVADQDKSSCLKRCFRLYERSLNRMAQTVENVQRKSFDFMDCSHQCESSDNANATDLSNFIKSNCFSLMKVTDLSLRCLCHIPDSLPKFECIRRYHSFVEIRCSSHLDEAVRLKIQINGSTKEICRDEFLRQCHIYAVVEKEQIFKDIFKSKNANDEAKLQNWVTKVLIKCISKNHIRNGENFRKNATILEIISLHEKHHHEEEIENESSTPTYAITTKKLFSPDNDLLYSPPNFFYSSLRWRSPTPQSYTRPTFNVDDFDFGASRVDNSTNYVENNYKMREIESKNPAHFHGAQNGSIHMDNRHQPIILQTANPIFSSTRIHNITTAGAAQISTTHQTGKQLGNSATSTSPERFLPTKQKLGKQQILLMNGTIQDNAQHSKILIRPFDTSFEPVANRSISVGMEAAHIKKQTDERPTLLGQTIIYKAPIRKYISPDDHHPADAGISASDNEWTESHLLAIYAILLSLAITVAVLLIAAFVVNMQKSHQAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8H1</accession>
    <name>A0A0N4U8H1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS208</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8H1"/>
    <dbReference type="STRING" id="318479.A0A0N4U8H1"/>
    <dbReference type="WBParaSite" id="DME_0000334201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000334201-mRNA-1"/>
        <property type="gene ID" value="DME_0000334201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5815019at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF27">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000334201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25588" checksum="1D4BB9DA4F5EC57C" modified="2015-12-09" version="1">MCDYFSKQVRHRKEKLMYARTYDAIYSLAVPEVFCAVLVRVGNVGDGGKWVCNPFKAGTTVCNIFSLGVNNDISFEKEIWQLSGRQCNLFCFDKVKQNKNIYDQLKNLNATFKLAQIDSVTRKTFNKYSIQYLMRFYNISAIEIFKIDIEDQIFCQVLIEIHGTPKKQYFLLKLLSRHGYYLFSYEVNGYTEKLCEYSFIHESCIQKYSVKKIAKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA63</accession>
    <name>A0A0N4UA63_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Not3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS383</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA63"/>
    <dbReference type="STRING" id="318479.A0A0N4UA63"/>
    <dbReference type="WBParaSite" id="DME_0000401901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000401901-mRNA-1"/>
        <property type="gene ID" value="DME_0000401901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="594"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000401901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="724" mass="81833" checksum="F98DB86936A6EB35" modified="2015-12-09" version="1">MAEKRKLLNEIDKCYKKIDEGVELFEETMSKMQEANSENQREKFQDDLKKEIKKLQRLRDQIKGWQNSSEIKDKEKLTHYRKVIEQRMEQFKDIERENKTKPHSKQGLSAEEKLDPREKEKAEAVEWLQCQIRCLEDEADKTESRIEMLATAEQTRKKGKRDDTKKGEKEKMKKLDDLRKHLDRIKFHISKVEICMRLVNNETLESSRVMDALKEPFDIYIEALDHESENDPEQCDPENAGVYDELDLQSYTPQLGGAIFGAGDAEEKTDSNNVDQKSVSSDSPTSLSAQLKETEENNLKQRHLSGGQISTTRSTPVTPLKLSNFSQVSVDSVNSPPASATPPPLPGIPYNIAAGLGTKSIKANFTPNSSVKQPLDIVRQPSGVISITTTTTTTSSITQPLGHSHSLNDENAAPNPVHVELPAVAATSQAMVVSPAIIPNPRSVTPESNMIKRFSISSAANAQQEVITLKPVIAQASSTADVNMLQPPNSLMNPYSVQPVMRPSSPNDTNTTNTTCLQTGLNISVSVPTTPTHPSSNDLDSNALRHTSRHDYQNQLPKTVMATIPAWLGASPLGKIALTGDMEKQLALLDNALTRLPAPMDSEKPRSYLPKMTCMTPSYYPQCAPPNADTLEYYLRLSPETLFFVFYYMEGSRAQLLAAKALKKLSWRFHTKYLMWFQRHEEPKQITDDYEQGTYIYFDFEKWAQRKKEQFTFEYRFLEDKDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAR1</accession>
    <name>A0A0N4UAR1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Intermediate filament tail domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8135</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAR1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAR1"/>
    <dbReference type="WBParaSite" id="DME_0000425201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000425201-mRNA-1"/>
        <property type="gene ID" value="DME_0000425201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000016">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1260:FF:000003">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016451">
        <property type="entry name" value="Intermed_filament_ifa/ifb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF6">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005546">
        <property type="entry name" value="Intermed_filamnt_Ifb-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="80"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="7">
        <location>
            <begin position="465"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000425201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="588" mass="67610" checksum="509D7F4AEC14A2F4" modified="2015-12-09" version="1">MSKHSTDSDYEIAYRSTIQPRTAVRTQSRQSGTYATGTVGGGGGRVLKMVTEMGSASIGGISPALSANAAKSFLEATDKEKKEMQGLNDRLGNYIDRVKKLEEQNRKLVADLDELRGRWGKDTSEIKIQYSDSLRDARKEIDDGARRKAEIDVRVARLRDDLAEIRNRYEDVQHRRENDREKINQWQHAIDDAQSELEMLRARWRQLTEEEKRLNGDNARIWEELQKARNDLDEETLGRIDFQNQVQTLMEELEFLRRVHEQEVKELQALLAQAPADTREFFKNELALAIRDIKDEYDYIAKQGKQDMESWYKLKVSEVQGSANRANMEASYQREEVKRMRDNIGDLRGKLGDLEAKNALLEKEVQNLNYQLNDDQRQYEAALNDRDATLRRMREECQTLVAELQALLDTKQMLDAEIAIYRKMLEGEESRVGLRQMVEQVVKTHSLQQQEDTDSTRSVRGEVSTKTTFQRSAKGNVTISECDPNGKFIMLENTHRSKDENLGEHKLKRKLDNRREIVYTIPLNTVLKAGRTMKIYARDQGGIHNPPESLIFDGENTWGVGANVVTSLINKDGDERATHTQKTIQTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAT1</accession>
    <name>A0A0N4UAT1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calmodulin-binding transcription activator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8160</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAT1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAT1"/>
    <dbReference type="WBParaSite" id="DME_0000427701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000427701-mRNA-1"/>
        <property type="gene ID" value="DME_0000427701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407555at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000427701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20851" checksum="3C0E779D3077E502" modified="2015-12-09" version="1">MGTARFSSIVCRFSSSSFSNNTNNATAATTITNNNNNNRSNNYREQRELYEAAKIIQHAYRQYKARISTQRQNEAERNAAILIQSYYRRYKQFCYFKRLHKAAVFIQKHFRMHKAVMRGDSNHCLSVNVDDIKHVQYDDATFNTPTQLTMKEHQAALTIQHAFRQKGREKGFWTLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAX3</accession>
    <name>A0A0N4UAX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E2F-associated phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAX3"/>
    <dbReference type="STRING" id="318479.A0A0N4UAX3"/>
    <dbReference type="WBParaSite" id="DME_0000432701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000432701-mRNA-1"/>
        <property type="gene ID" value="DME_0000432701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000432701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38333" checksum="CC73E648EB33368A" modified="2015-12-09" version="1">MERLEPFEKLECDYYLDDKGGWYSDCENNSSDSSDDDFRERVARLAGIRFDCRKKRGNKKVENKDEFESDMDSELDQQFVDHTSKNVFSSSLDKISTGSLDSQTSDLKGIDMNRYEIKVSINDCPEIIGSLEVRERLNESKQQSSFDDQDNILRKAVDKIRKGCRTPEFDFYDPNEDDDNEKWIYEQRKRMKVITSRYSLDRLGCGDNSDNTNGPSNKLPDSDAVLSCPACMCLLTRDCQRHELFPNQYRAMFVENCKVISDQMLFLPTSDKIKKGKRNSTDPMPNTFVANINTIPKEDLFRPVQCSVCNTNVGVFDFDEVFHFFNVLSGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAX9</accession>
    <name>A0A0N4UAX9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8216</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAX9"/>
    <dbReference type="WBParaSite" id="DME_0000433301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000433301-mRNA-1"/>
        <property type="gene ID" value="DME_0000433301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF55">
        <property type="entry name" value="POTASSIUM_CHLORIDE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="651"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="730"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000433301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="788" mass="86586" checksum="A6D0D614E5C51DC2" modified="2015-12-09" version="1">MIISFLDEDGIDLEEGHASFISAYVTPGPKQRDISEQKKANLGMMLGVYLPTIQHILGVTMFIRLFWVVGIAGILHTILLLLCCCLCTLLTSISLSAVATNGVVESGGVYFMISRNLGAEFGSAVGILFYLANTVAASMYLVGGVEVMLLYIFPSITIGGHEAHSETGIWGMMSHNYRIYGTAFLLLEATIVAMGVRFVQLLAPVSLFCVILSILACFAGGIEKAILKNVTKFLENLNPMYMAAGESYPGVPADDTGLEVSQDFRTSFFILLAIYFPAVTGIMTGTNMSGDLKDPQKTIPRGTIAATLTTSAIYFALAILFGSSITGPVLRDKYGRSINSSMIVALLSWPSHWVVVIGSFLSTFGAALQCLCSAPRLLQSIAKDDVIPALAPFAKVTKNNEPLLGLLFTALIAESAILLGAVDSIAAVLDFFFLMSLSLMGASLCFFIMFASQWQYALISIILTFVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKVEDKDPHPKNWRPQLLVLVEGTWSKEIVDMRCINLLNLAGQLKAGRGLAIVIAFIKGEITDPADRTRAEEVKSRIQQDMINAPLRGFGKTILFNENQIDGCISTLYQSIGIGGLKPNTVMINWPKIKLLQAIAYNQCVMVIKGITDFPLATARLSGYIDIWWIMFDGGILMLIAYLLRQNKVWRGCSLRIFAIADVPEKNEKKKMLQKYIYMLRIDAEVFVSFFIIFDGSSVILENSLQSQLVIINLPRPPKKNKANFENYMSDMEILTSKIPRVLFISGSGKEVITICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB86</accession>
    <name>A0A0N4UB86_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P protein subunit p20</fullName>
            <shortName evidence="4">RNaseP protein p20</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8334</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB86"/>
    <dbReference type="STRING" id="318479.A0A0N4UB86"/>
    <dbReference type="WBParaSite" id="DME_0000445101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000445101-mRNA-1"/>
        <property type="gene ID" value="DME_0000445101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036572">
        <property type="entry name" value="RPP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000445101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14173" checksum="E8CE5B85F9B22FD3" modified="2015-12-09" version="1">MEEEKGGIDTVEYEIKKGLPPRFPRTKSDIYITRHTSIGAQKARIEKLLDNKFNSVTLHGLGAAVNRTVNVALQIQRKLVDSVKLDVRTSTVRVTDDLFPLYDEVDFKTNVRNISAVHIKITRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB97</accession>
    <name>A0A0N4UB97_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8347</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB97"/>
    <dbReference type="STRING" id="318479.A0A0N4UB97"/>
    <dbReference type="WBParaSite" id="DME_0000446401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000446401-mRNA-1"/>
        <property type="gene ID" value="DME_0000446401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000446401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15736" checksum="0940126C13CF7246" modified="2015-12-09" version="1">MNNDMNETRRELADLVKRRSEIAEILSSLEQQIYNFEGSYLDETAEYGNVVKGWDRFALVAPPSKNSLKLEKKGSRKSLRDSERIFSNSSVTSPAALKNSVSQHIAHEDSPSNNNRYNRDNHSKKGSKKSRRNDSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBI9</accession>
    <name>A0A0N4UBI9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8452</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBI9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBI9"/>
    <dbReference type="WBParaSite" id="DME_0000456901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000456901-mRNA-1"/>
        <property type="gene ID" value="DME_0000456901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000456901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36390" checksum="8D6C4FE42613D3A6" modified="2015-12-09" version="1">MNGRKANGALEDNTGLKRLINMEKGTVFGRTASSWAKILLFYVVFYAFLASFWFACLMAFLSTLDDKMPRYYGKGTIIGINPGVGYQPWLVEDPDSTLIKFNIRDQKSYQKYVDTLNEYLKKYENKTDTRICSDTESNADLFKEGSPKLQALNGSDVPLACQFNLTIFNEAGCGADNEYGFKNGQPCVFLLLNRLIAWKPVDFAVDSVPEIIRDRYKPNFITFKCDGTSDFDKEHIGNLEYIPEAGIDGRYFPYTVLSNYHQPVAVVKFKNLPRNKVVLVECRAYAQNIEHDVSSKLGLVNFELLIEDGEIEKNAAQRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBM9</accession>
    <name>A0A0N4UBM9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRRNT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8502</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBM9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBM9"/>
    <dbReference type="WBParaSite" id="DME_0000461901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000461901-mRNA-1"/>
        <property type="gene ID" value="DME_0000461901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9229163at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000461901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54141" checksum="34A52AB91F02407F" modified="2015-12-09" version="1">MRYSFNIFFIFHIHSIFINIFSIIFIILFICINHTKSLNEFDSLDETYNFAEITIFKSKCPPQCECEENFHRRSNRETNEISVNCHTGGLSQEDFAYIIKHISDKVTILDIEAPRTKPNQLLWDDNLNRLTRLRTLRLINCGIPAISRVLRLPKLEILDLRGNRIEHITISMFSGVPSIRTLNLAENLLSILPTGAFTYLRQMEALFLSYNNITELSANLFRGLETLKALHLDGNKIPSYQINNVISDISQLEQLELNYCGINSIRQVNLNKLISLRKLGLAGNSLKIIPTNDLRNLPWLSSLNLADNDIRGVAPYSFASTNITRLSLAHNKLGQSPFSLKIDSFAHMNLLELDLSYNGHEYFDSFVLGSAQLTIETLHLSGNGIRVFHEHLTSNMSSLKHLHLADNNISQIPANLPFEYSQLTFLNLSNNELTDLPQYSRYILPALRILDISSNRISSLSMNVLDSFINDLDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBR2</accession>
    <name>A0A0N4UBR2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">T-complex 11 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8545</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBR2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBR2"/>
    <dbReference type="WBParaSite" id="DME_0000466201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000466201-mRNA-1"/>
        <property type="gene ID" value="DME_0000466201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000466201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39503" checksum="883E7F16B685CF27" modified="2015-12-09" version="1">MEDEFCDNDNDRSDKETRKSSNMNAPSSSSLKRKIDEYSTNENLIESDFFPDWANDKLVENIDEILDVSLTIENMALVHEIALNDEFKIDERPLNILEKQVKEFLHKAFWDNFRENFMRESSDHSHELKLLRDIKKMLLDLLDNRHVRLRSEVEFMLDEKLLTQQIENNCLDIKGLSIRILDLMGRLCAPARDEAIAEIRGRTDVIEVFRGICELLETMKLDMANFSIRQYRPLIQQYAFEYERKQFQKLIEHNPSTLLFLLIVYNKIMYNVQGSQNQQLNYLRTRGNDNYFINIQIDHLHLKALAASYFQLNITTCCLSVSYNLAGKDIVTSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCE7</accession>
    <name>A0A0N4UCE7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCE7"/>
    <dbReference type="STRING" id="318479.A0A0N4UCE7"/>
    <dbReference type="WBParaSite" id="DME_0000493901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000493901-mRNA-1"/>
        <property type="gene ID" value="DME_0000493901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05128">
        <property type="entry name" value="RasGAP_GAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF148">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="264"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="511"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000493901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="750" mass="87348" checksum="D02CF5F690840C14" modified="2016-06-08" version="2">MCHEIVSIDSKFKRFNVNDEFIHEITNSFSNLHLIISENGRIPKQIGRVSIKKRDVIKYCGKERWFHVTNSTKQNDISGQICIDMFYDHQKSSISIKVIDYLGINVRDSVELYLLVTVQGCGKTESKKLRITPEKGNEETILIECENFIRDDEQRPQVTLALWHDVFGGFSSFFHGQVRIFLDENTLRTKEEHSGPQWYYLKPRMSVDENEESTSENTDSSRLGEIRLRLLYMADHILPLQLYKPLQLNLLKSLNINPFLLQIDIASIARPLMKIFFKSDSIRPLLRILCSHDIIKCQDINTLFRSQSLASKIIYEQMKFLGHHYLLISLKPVIDMVYNEHKNCEVDPSKLKSDDCLESNKWNLITYGEIAFSRIVDSYYRCPVSLREMFFDLREVVLVHYPGREDVQRLALSSFIVMRFFAAAIMNPKLFGIKREQPDPIVSRTLVLVSKILQRLSNCVVSSVSLSVKEPWLDSVLQRFTDETHRLAMMKFLDRISLSDCDFSVSGENLSILRDGYFIERKTRERKKILNKLINQKRRYVILTETEIYWQNSKADDEPKGRIQLQEVNLIEPVKDEKNVFRISSPNCEIQLQAPSTVEMNEWIVQIQKQRKRQLMIALRGNESSELLEIDTERELETLHMTLYEHAETLKHWKNALEGTAIPEGHPPLPNNVLEQLNNSSNPEEAKQKFHTTIHDILHGTLLIEKAHHDIVANFMNQVRNGKSLRELPIGDDNYLLLKSRFQRIPTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD45</accession>
    <name>A0A0N4UD45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9027</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD45"/>
    <dbReference type="STRING" id="318479.A0A0N4UD45"/>
    <dbReference type="WBParaSite" id="DME_0000522801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000522801-mRNA-1"/>
        <property type="gene ID" value="DME_0000522801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH_VHS"/>
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    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
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    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000522801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48409" checksum="99D996FA42C18EA2" modified="2015-12-09" version="1">MSISTIRRQVKNVAYNFSDAQVKVREATSNDPWGPSTALMSQIADLTHNPSSFAEIMSMLWKRLNDHGKNWRHVYKSLVLLDYLIKCGSEKVAQQCRENIYSIETLKDFQHVEDNRDQGMNVREKAKQMVALLFDEERLKNERTKFMITRRKFMSGSAISSDGTVRHVRRSDTGPVFESELEDARPGSAGEEEMQLQIALAMSKEESEKEEELRKQDDIGLQMAINESRRELERISALANAKPQMVSGSTLSQSAIDDLLSLGVGEPVGSESSVWGTTTVDPWAPSRATANNSVYPTLPLAENKNDPWSLSLSPPVSSSSGAFTDPWSPATSLDPASTNLISEDEKAKKRSNAKTPESFLGENSALVNLDNLLGATNVTSKPASNPFLSGTGTGMANPFVAQQRPSPTLNQMLNQNRSMSNDGANRPTTSHQPTNPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD82</accession>
    <name>A0A0N4UD82_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD82"/>
    <dbReference type="WBParaSite" id="DME_0000527101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000527101-mRNA-1"/>
        <property type="gene ID" value="DME_0000527101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000527101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9331" checksum="30DECC1554E06AB1" modified="2015-12-09" version="1">MSIAAVADRLSAAFITPALPAKMTTSTYSSSHRGHNRGDWNVRVGHDAVKMNSVIGKYGIWGASGERLLHFAEHELFVAFSNGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDR2</accession>
    <name>A0A0N4UDR2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS589</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDR2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDR2"/>
    <dbReference type="WBParaSite" id="DME_0000548301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000548301-mRNA-1"/>
        <property type="gene ID" value="DME_0000548301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000548301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36247" checksum="E55C781924035203" modified="2015-12-09" version="1">MSKPKVGINGFGRIGRLVLRAAVDKDAVDVVAVNDPFIDIDYMVYMFKYDSTHGRFKGHIAAEGNKLVVSAPGKSTHHITVHNSKDPAEIPWGADGAEFVVESTGVFTTIEKASAHLKGGAKKVVISAPSADAPMFVMGVNHDKYDHANNHIISNASCTTNCLAPLAKIIHDKFGIVEGLMTTVHATTATQKTVDGPSGKQWRDGRGAAQNIIPASTGAAKAVGKVIPALNGLLTGMAFRVPTADVSVVDLTARLAKPATMDEIKAAVKAAAEGPMKGILGYTEDQVVSTDFIGDSHSSIFDAKACISLNPTFVKLISWYDNEYGYSCRVVDLITYAHSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDV1</accession>
    <name>A0A0N4UDV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Complement factor H-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9267</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDV1"/>
    <dbReference type="STRING" id="318479.A0A0N4UDV1"/>
    <dbReference type="WBParaSite" id="DME_0000552601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000552601-mRNA-1"/>
        <property type="gene ID" value="DME_0000552601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874173at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042273" evidence="1">
        <location>
            <begin position="18"/>
            <end position="1766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000552601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1766" mass="198716" checksum="9FEF35B19E070F8B" modified="2016-06-08" version="2">MKFVWFVANLFYLIILSKEKCRNIRPHSLLNAQITVPRRSCLICGCKEGTVIKITCNEWYYFENQDYADGQALICYRNQWINKRHVAESPAKCIRGCKVLNDNDMKNATYSFGFAFPPWRQKNEDDFTCLGGNIGWKRAIGSVLKQGGDDGRPGLCNPLCLALDPINDFAAFTIVENQPSEDAIVTMNGKKYIYDGYIYSFRCEKGTMYDKNGPHHAKQRQQLVCIGGEAGYQDLATVVTNVDKKCRSLNSNSIAKGCHATIVCGEFHYFDNKDYGNGMKLICTDNGWVDQSGKPYDKDKPHKNGDKTYWSNGVKVTTKCKKGFVRLDPSERDEPNSFICIGGSDGWRNSKTGKNDVHPASCEPVCSQITKLPQGTRIKREPKDTVIFDGIEYIYPQAMYVYECEDGYEYPENSPYARSKQQTIFCAGGLAGYKDMDSGELNAEPFPCQVKGAKGCDPITTMTTPNAFINENKCELEKGKVPKGCQVTIECKEGYHLFNENNKPIIAKQQILLCEAGKNGWVDKNNKKKNATTMKCLPVCKLPKELKNAIIVAKPDQSDLVGDGTLVREGGQMIVKCKATYVMPTESEREKVEVALECIGGPSKWKNKVTGMSGEEPGKCLGTCIAITDPPKGVAIIMSPSAFYHEGKMVIIENQQYIFKCNKGYQYPANKAHSKQGKQIIECKNGKDGFYDPDSQQINAKPEKCVRGETPGCKKLDPKSPPPNMKITSHKGCSLDHGKTVVGCKLVLECEEDYFTVDDTYIITGKQELECVDDGTKSDWQNKEKNRVMDFMKCHPGCEVRPMPNTKVIQAPKPIIVGGKQFYKSGAKMIIQCKEGTSPPNADINAPLKPREYECKGGKENWLEKETMVNEKWPGESCLGYCDAINRAEGFRFLQQPALYEMNEKKIVRENAKYIIECKKGYHYSKESAIEKDGKQILKCSNDGKYKDLTRNKIVNEPEKCKKDIGPGCKDIVQENWATIRKQCGKGDEQIDSNHCSLIIRCKEGFFPEDKAYHKDGFQKIHCKDGNDWMDQNNKIIKDSLKCAPGCIQPSSSNSPIIIKRNSSNIVNINKDIYILPSGKIEVICKDGYVWTATNKRQGEIIECVGGDRKWKNDEDVKIDVIDEACTGICPIEMKQIPQNVFLAKNATFHELKGEMYVLDKTAFEFQCKTGYVYLSNPYKNTKRQTIRCNGDTKKYFDDDTKQYDFKLENCERPPNANECKVREIKQDADSTDIKIKNCKKDGEFYPTGCIIKVQCAEGYYPKDELYQKSVSQELRCGPSGSGWFDQYNRPIKERLYCIKGCISRDVKESLISSANTTINTEITIYKFTDGTSVKCTSKEKKVDINVNLLRDSNKINKFYCSGDKKNDKNISSNIEFDNKCFNSCIAIENIPRSVSVFKFPNIFEHDGKRYAQNMKPYVFKCNDGYAYPKETIHNRKARQALSCNSETHFYDDIDTGEKNVGVKACEKLNGCLMIKQDPQVEISLKNCIQSNELYIAGCVITMTCPKTPQHYPSDNKYWQDGMQKLTCSADDDSGWRDQYGNIIDKPFKCTQGCIPRPTSPPSTLTNTRSESKMMNKMEEIEKLDHKFFCEPKVGSSDGFRNRAIVPDTCINACFAITDIPDTVFMEKKPNRLFDFKGIKDMIVAFDEIYTFRCKDSNGYFMTDGKPKQRKLKCDGETGAYTNVDTGEKDVQLVGCTSNIHSGTATANPAFEKVVYEHNGAAPVNPGLGKVVYVHNGTAPVNPGLGKVVYVHNGTAPVAALIAFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDY1</accession>
    <name>A0A0N4UDY1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9299</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDY1"/>
    <dbReference type="STRING" id="318479.A0A0N4UDY1"/>
    <dbReference type="WBParaSite" id="DME_0000555801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000555801-mRNA-1"/>
        <property type="gene ID" value="DME_0000555801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="13">
        <location>
            <begin position="57"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000555801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41525" checksum="13D8B1DC25E1AC6D" modified="2015-12-09" version="1">MLSRRNTMNSTSSAVFNENGQVGKMNFFLLILSFHFIFFQQFNTINLEKCDLATKGKTVPFSKAIRIDGFEIETWFSSPYPEEYAQLSVFYLCGFCMKYMKSEEIAKRHRDKCELYHPPGDEIYRCGNISVFEVDGNLSRIYCQNICLMAKLFLDHKTLYYDVEPFLFYVLTKNDINGCHFVGYFSKEKYSAQKFNLSCIMTLPCYQKQGYGRFLIDFSYLLSRRENLVGTPERPLSELGRISYRSYWKSSILEFLYSSVSPKNLKKLTIRSIKDYGIKSPLGNRLNISPKKSPEFPVRTPQVKRLNISPKKSAKRSALGDSISLSSQKSQQKSATMLGRRKLKHRSLDQVFLQRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDZ0</accession>
    <name>A0A0N4UDZ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial nucleoid factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9309</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDZ0"/>
    <dbReference type="WBParaSite" id="DME_0000556801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556801-mRNA-1"/>
        <property type="gene ID" value="DME_0000556801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14040" checksum="1218E79C16819027" modified="2015-12-09" version="1">MSNHLYRKFMELANRWPNEPLKKSNRNTVLFIRSEIEKYFRNEMNSNSNSVLCEKRLKSLEQLLSNVHLTNYPHSYRSGVFGLTIAQLQEVNSEEGRKAIGLVKRPSLFSKLKSFIFSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UER8</accession>
    <name>A0A0N4UER8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9414</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UER8"/>
    <dbReference type="STRING" id="318479.A0A0N4UER8"/>
    <dbReference type="WBParaSite" id="DME_0000589001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589001-mRNA-1"/>
        <property type="gene ID" value="DME_0000589001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47638" checksum="DEDA42A53BA15BD3" modified="2015-12-09" version="1">MSGGVYGGDEVGALVFDPGSHSFRIGFAGEEFPKGDIPSHLGIQEVLDEVDNTIDQDQKSQKRKKYHIGSTVLGVPRENTTIETFMKDGQIDNWDIFEQMIDYSYKQIFYAESIYQPVLFTEAPWNAKSNRERLMELMFEKYNVPAFYLVKNAVLASYANGRTSGLVLDSGSSQTSAVPIFDGYCLTHAVVRAPIGGDLIVEQCRLMCEEQQIEIIPAYKIATKEAVSENEAPIWTMKKGLPNVKRSFDDYMRKQVLEDLASSVLQVCDTPIDVEFAEKLPSSPFCFPCGFMKEFQAERVKIPEGLFDLNYLKGIDKSILMSVSQIAATSCGMCDIDIRPTLYSSLMVTGGNSLIMGFTERLNHDLALKCPPTIKLRVNAAPTPMERRFGAWIGGSILASLGTFQQMWVSRAEYDDCGKTLVEKKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFA7</accession>
    <name>A0A0N4UFA7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS1046</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFA7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFA7"/>
    <dbReference type="WBParaSite" id="DME_0000610701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000610701-mRNA-1"/>
        <property type="gene ID" value="DME_0000610701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09937">
        <property type="entry name" value="SH2_csk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000023">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035027">
        <property type="entry name" value="Csk-like_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN51073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000610701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29366" checksum="93691776F2677AE1" modified="2015-12-09" version="1">MSTIDGFLNTSYEKNSKSSESIHSFQRKCLSSNEQSMPWYHGNISREQTENILLNKTDGTFLIRDSTNFPGDFTLCLAFNGRVEHYRIYQTNGILTCDHEEHFDNLTQLVSHYKRDADGLCHRLVTPMINEKYRIPREAISIEDRIQVFKQTSLVIRRSNLRLGDTIGHGEFGDVLLGDYIGRRVAVKVLKRSAMVNSLLDEAKFMIGLEHKNLVVLIGVVLDDSRDLFMVTEYMANGNLVSFQLLFIVFVIFNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFW0</accession>
    <name>A0A0N4UFW0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFW0"/>
    <dbReference type="WBParaSite" id="DME_0000634801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000634801-mRNA-1"/>
        <property type="gene ID" value="DME_0000634801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000634801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6204" checksum="1F8F16D9AECDB309" modified="2015-12-09" version="1">MLHLERARSFLLYIFVNGDISVNTFRFGRITMPHENLLKNSLVGRFGLNVVALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFW3</accession>
    <name>A0A0N4UFW3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1249</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFW3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFW3"/>
    <dbReference type="WBParaSite" id="DME_0000635201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000635201-mRNA-1"/>
        <property type="gene ID" value="DME_0000635201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="8">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000635201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20280" checksum="4AFC0E970823F831" modified="2015-12-09" version="1">MVFGTRRNGETLESATYKAVQILECGGVVAVPTDTVYGLVTTIPNAKKIYALKRRNPLKPFVLCSEKTIESILRILKNLLPGPFTLIFKRSTLLPKCFNPDHDTVGIRIPAHSFVLSLLNRLGSPLAQSSANISGATNSPICIEDFGDLWSQVDLVNEFGEISREGSTVIDLSVRGTYSIVRDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG10</accession>
    <name>A0A0N4UG10_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S5 DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9513</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG10"/>
    <dbReference type="STRING" id="318479.A0A0N4UG10"/>
    <dbReference type="WBParaSite" id="DME_0000640201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000640201-mRNA-1"/>
        <property type="gene ID" value="DME_0000640201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041120196" evidence="3">
        <location>
            <begin position="20"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000640201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="697" mass="78765" checksum="03DC36BC77BC80B9" modified="2015-12-09" version="1">MSPIWLLLIYFVYFTKELTEKKQSTSSSEENSEGSDSTSSNSNSRERDNLILLNNDGELYDVSAENQSPATYDITEEDIYKMEQIGVTNTQVPSAGDEFIPEKDKEDEIVLFNFLNLQTFRYLKDAEKKADELYRTAMKFLDKNRVSSFEAKKAAYGLLEEAARLKHRDSMKLIAYAYLFGDYTRWSIDEARTTFELLSLSGSPDAQLALAFLHGTGIGFPESSQAKALVFYTFSALGNNPLAQMALGYRNWAGISVPQNCERALIWYKKVASRVASQVRLTGGMALQRIRLPDEFDSTIPSAAQATNTVLDANLLNYYKYLADKGDIQAQIGLGQLYLTGGRGVERDVELASHYFSAAAESGSSSAHAHLGKMYLDGTTATPQDNQTAFQFFKKAADRGNPIGQSGLGVMYLYGKGVKQDYSKALKLFTLAAEQNWVDGQLNLGHMHYRGLGVKRDFKLAVKYFQMASQSGHILAYYNLAQMHATGTGVLRNCKTAVELYKNVAERGRWSERLMEAYMSYRAGHKDEAAFKYLFLAELGYEPAQTNFAYIIDQGELGMFPKKEALQRAFLHWQRSAEQDYVVARIKLGDYHYYGYGTPVDYELAAAHYKIASDRHQAAQAMFNLGYMHEQGLGLSKDLHLAKRFYDMAAETSVDAYIPVTLALIKLSLFFFYDLLREVSFEFFWLKIVDMILKRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG39</accession>
    <name>A0A0N4UG39_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9547</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG39"/>
    <dbReference type="WBParaSite" id="DME_0000643601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000643601-mRNA-1"/>
        <property type="gene ID" value="DME_0000643601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877252at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF68">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000643601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23682" checksum="9224A7012B3B4F12" modified="2015-12-09" version="1">MKNERNSSNILLFIGVFGARCDQTDWILHFFFISNFFPNECMPWMWYLSLDMQLHLIAPFLISVILKWRTIGRNINIAIAVASILYRLVILIIYRHFKIFSRALWATGLAIFIWLLENNYWKFAYKLLGNEKWLSLSRVSYGLYLAHEPLILYFVWTRREAIKARSLFYLIVFGLEMYILSTIIAIILAIVIEVHFCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGA7</accession>
    <name>A0A0N4UGA7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein polybromo-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9627</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGA7"/>
    <dbReference type="WBParaSite" id="DME_0000651601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000651601-mRNA-1"/>
        <property type="gene ID" value="DME_0000651601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000651601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8272" checksum="59D7AF7C73C2FEA1" modified="2015-12-09" version="1">MASKDDVERMFEATTYIGKRSRKKSNMARQDPPWISPSTAEVDDNVKSYQRLEKAGLKGNIGIYHTRHNSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGK5</accession>
    <name>A0A0N4UGK5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCA tRNA nucleotidyltransferase 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1274</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGK5"/>
    <dbReference type="STRING" id="318479.A0A0N4UGK5"/>
    <dbReference type="WBParaSite" id="DME_0000663001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000663001-mRNA-1"/>
        <property type="gene ID" value="DME_0000663001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="9">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000663001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46564" checksum="8BF0E157D6F771CE" modified="2015-12-09" version="1">MGTAKHRTPITMKINSPQLQLILTPELRILENYFKSNNFQLRIAGGAVRDLLMGMTPADVDFATDATPEQMKEIFMRENVRIFNKKGEEHGTVSCRINDKENFEITTLRVDILCDGRRAEVEFTTDWQLDANRRDLTINSLFLDTDGTVIDYFGGINDINLRRVVFVGNARQRIQEDYLRILRYFRFFGRVALSCDAHDESTLQAIIENKDGLDSVSGERIWSELKKICVGRLGGEVVTIMLEKCHLSSLLGLPPHCEKRLAEFRKIYDSNIDRFVQPMTLISSLFSNLDDLNVFHLRCKLSNIERLLSQFIIEKRDEMMKTDRSSKNRQFPEKMTLDRRTKVLELAKYCMVNNAVLEELDNWHIPEFPVNGKDLLNFISSGPIMSEVLTTLFIIWRKVFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGU1</accession>
    <name>A0A0N4UGU1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1342</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGU1"/>
    <dbReference type="STRING" id="318479.A0A0N4UGU1"/>
    <dbReference type="WBParaSite" id="DME_0000672801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000672801-mRNA-1"/>
        <property type="gene ID" value="DME_0000672801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF30">
        <property type="entry name" value="DALLY-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000672801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44149" checksum="0293C6C5DE339CAC" modified="2016-06-08" version="2">MKEETSIIKGKCKNKNTFDDSSNNAIRERIKLIVDVGCQNKCRVTDDTPLVKLTDHSNAVNNYDCSCSKNREVLTKADENLRLLLRISSVRLQTYLQNLAHLTNAEINLIVQRRKWNLYDEIRRNFRQFLTQPSFADSIEELFHKILNQLFMSTDLIPKRIEVDMEQAVQNFFVQIMPSTFLCMTGGSCLSVTQSYANCIQKNSISWKIFYGDGPNKMAISLRQDILKYRIIEKSIDKLYRFVLESESVNESCVASYASIVHCGQYCIQKYSAIDIPGYCRDKCRSVIAGCLGQNAIDWDSFIIILRKLSIDFDKGFSALDRSIIDAISHALEYNAPTIAKTVLRKCGAVNVSKAAIKIESTVLKKPNIERKAASMIQEVGENSISISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGZ6</accession>
    <name>A0A0N4UGZ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1402</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGZ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGZ6"/>
    <dbReference type="WBParaSite" id="DME_0000678801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000678801-mRNA-1"/>
        <property type="gene ID" value="DME_0000678801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000678801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40854" checksum="6D7E3921F0FBA0AD" modified="2015-12-09" version="1">MFSGSFGNRTSNLFASSTANPQNPLNDIEVPSPPDDTVEALKFNPQIAGQPVFLVSGSWDSVIRVWQISETGQCEAKAQQTIGGPVMDLEWIDDGTKIFIASADKQIRLWDLASNQMAVVGTHDEPVKSCHWVKSTNYSCLMSGSWDKTLRFWDMRQLPNQTSLATLQLPERVYCSDMLHPMAVIGLANRHIKVYRLDGEPTEIKDIETPLKYQNRCIAIFKDKNNGLPTGFALGSTEGRVALQYVEAPNPKDNFTFKCHRSPDLINGYQEIYAVNDLAFHPSYGTLVTVGSDGKISFWDKDARAKLKISDALPAPVTRVTIHPSGQMMAYAIGYDWSKGHEGHSSVNAGSKIFLHACDEDMKPKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHR7</accession>
    <name>A0A0N4UHR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9841</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHR7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHR7"/>
    <dbReference type="WBParaSite" id="DME_0000711101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000711101-mRNA-1"/>
        <property type="gene ID" value="DME_0000711101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15440">
        <property type="entry name" value="7tmB2_latrophilin-like_invertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000200">
        <property type="entry name" value="Adhesion G protein-coupled receptor L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048072">
        <property type="entry name" value="7tmB2_latrophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF467">
        <property type="entry name" value="LATROPHILIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="12">
        <location>
            <begin position="269"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="415"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000711101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="869" mass="98521" checksum="00030465639EF6B0" modified="2015-12-09" version="1">MFSLLLLCRCNGKQLCSFVVNNSYFGDHCPKTSKYLDAEYECITTSTTTTTTVTISTINTTIESKQTASSMEINTIISVNEDDETKMLKQGCPSIKNRDFNWPWTESNSIARMPCPNGAKGHAEWLCDKNGQWNKNGVDMSRCESFWSKNLQEEAYRTDDPIEKLETLHEIQQMTRKEILLAGDLIALSKAIVYSIPSHIQPENSEVFAEIIVEIVNNMGRETQSQAWSDLNFIQRREVADSLIESINHVASAVMSNIAPGTTRTVIKPSVELEISNVKIYDYIMFPSMSLYKNTYDTIDIPKEALSLRFSPQDYAKVLYASYTSIGAYMEPEPYSRFNGDIIKRHLASKILSASILDSANRIRSIHHLQKPVIITFNTMHTKNLSSPTCVWWNRLQLSWSTDGCQLEFEHGIVLTFITYAGCTLSIICLALSLLAFNCFGNGDERIFVHKNLSFSLLVAEIIFLLGIWQTDNNFHCGIIAAMLHFFFLAAFCWMFLEGIELYYMLVEVFQSNNSRKSCFFLFGYGCPALIVGISAWIDPDSYGTERYCWLRSDNYFILTFIAPVAIILFCNCIFILMTFCIVCNHSNIGYTPCKQSNNNIKNIRNWLKGAIALIALLGLTWTFGLLWLDQQSIAMAYLFTILNSLQGLFIFLFHVAFNDLMRNDYRKWSQRYSWLPSCAREELSSRISSPPYIASRQLKEISSGSSTGSEILYPSSTEKYPQRMAGIIEQRYNPVSTLLTRQRFPIYGVYDYATIVYGEQYPRPNSSTLFEHNKSSIFAPTEALYRPPPNFPPPPPPPAPSVTDNNFLNRPHSSTMTKLSNDSAFSDGSSNINNNNNTDMNNVGPSGMLLRMDLSKNPPVFVQGIIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHV1</accession>
    <name>A0A0N4UHV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9881</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHV1"/>
    <dbReference type="STRING" id="318479.A0A0N4UHV1"/>
    <dbReference type="WBParaSite" id="DME_0000715101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000715101-mRNA-1"/>
        <property type="gene ID" value="DME_0000715101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000715101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54564" checksum="E4BD43D50FCC3AF4" modified="2015-12-09" version="1">MSIHISDSRNMKFNEEPFEKFYEIAEELGNGQFAIVRRVVNRITRQEYAAKFIKKRRYATSRRGVLRINIEREITILKYIADSDNNNDNECLNEYEASIFIKQLLLALKFLHHLHIVHLDIKPENVMLVNKGDLKIKLIDFGLSRRILPGTIIKDMVGTPEFVAPEVVNYEPLTTATDMWALGVVTYILLSGGSPFLGENREETFINISAVNYNFNEKYFSKISPQAKDFIKNLFVKDIRKRATVNECLLHPWIRHVDNYNLKNTLLVNQRSAIPFDQIRSYKIRLKWQRAIEIIIVCNKMTANARLLLQSKNNNNQRTSRFDPIGETCLHISASNGYYDLLYYLYMKGASLTICDYQGDTPLYYSIRNGHINIVDFIISQNIDINYVNKNKETALHIATRYAQLEIVLLLLQRGANIELQDQDGETVLHISSWHGYTTILSAFCKYKPNPNIINKVCFLLSLIILMRIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIC8</accession>
    <name>A0A0N4UIC8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9989</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIC8"/>
    <dbReference type="WBParaSite" id="DME_0000735301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000735301-mRNA-1"/>
        <property type="gene ID" value="DME_0000735301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10440757at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000735301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9492" checksum="F71A2FF9DD8726BE" modified="2015-12-09" version="1">MDAKSDVQSAGKEQHNIDLANFNFGAFQLSTNSQIANNSISMPPMAQRNIFYDQHNPVQMHKPMNPQAVLITLCMGAELFDKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIH5</accession>
    <name>A0A0N4UIH5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10046</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIH5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIH5"/>
    <dbReference type="WBParaSite" id="DME_0000740801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000740801-mRNA-1"/>
        <property type="gene ID" value="DME_0000740801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000740801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41974" checksum="5BF68898B4953954" modified="2015-12-09" version="1">KDRISYINGSTDDADQKLTKEEEVIARFVRFNCATKTTIFEGNEVHYFIGNKAIDLLVESKKYGSAAKNPKFVNRVSAVTFMKVLLSKGLFFRARKLVAKRKENKKGDTSKSPRKRTKEDAEKESESSKEKKEDEKDSDENEDEDEDEKKKRKVKLELHQDQQFNDSNDVYVWVFDPTPFHKQLIGALIVLGTIAGCLFPLWPGWLKKGVYYTSLGGLICFGILLGIKLVDLFGTLKLIKYIKYKNILFFFLLLLTFYILLLSSRTVLFVVIWTATMGRHKLWILPNLTEDCGFFESFQPWYTYEYCPDGIKKRKKGEKKKTGEEPQRGFAYYAAMNYTFYCSELYFILSFKLNIYYRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIP7</accession>
    <name>A0A0N4UIP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaoptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10072</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIP7"/>
    <dbReference type="STRING" id="318479.A0A0N4UIP7"/>
    <dbReference type="WBParaSite" id="DME_0000748701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000748701-mRNA-1"/>
        <property type="gene ID" value="DME_0000748701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10022853at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000748701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1259" mass="145748" checksum="46F779FFC3130BF3" modified="2015-12-09" version="1">HANCISIEIISTDLDHITHRTATNRRLRRAWIYTNFHTTPSLFNDKPSKWKQCECEELPDEQGYHVRCRRQPWLTIPTILLDEQTANISKKVRKAKMIALSIIESSLVLLSQDVFKWQNLQLLDFTHNNIEIINVNAFRGLENMLYQLILNHNSLSAIPVWSLTYLYQLRYLYLQNNMIVDLKSDMFNETYLNNLQYMHLDYNKITILPTRSLARLPLEVFTISNNRISEIEKLALSPTIWFLDLKNNVLQQIPYLAVRELKSLRMFDLEGNNITEVKPNSEVEFTTDMDLILSNNRIRILGENSFNSFQKFNKLDLSYNQISTIATSAFSSISQMRQIDLSYNKIVHMAAGTLNNVAKSLRRLNLEENQFHTLPIALQALRSLEYLNMNGNKLTKLDNRTINNLKPAISELLLAYNRFIEIPSEALDGMSKLQHLDLSKNRIKNINRLAFGRFDGRGTSLIRLNLAGNHIEKIEDPGAFLYMSSLVYLDLSYNRIVKISENAFERLEGLESLFLQNNLLHSYPKRALSHLRRLRYLLLDNNPISSLPDSVFQDNDQLERTSFSRTLLYSISDRTFPAPSVPNLKSLNFASCRIHHIASRAFYDIPNLQQLLLNDNQLTTINSWAFSSLKNLQQLNLARNHINITMEYSISDMPSLEFLSLSHNRIQYLPKSLLVGVNNLEHLDISHNRLKIFNLNFMEQKLARIKTLDLSHNNIVTFDLNAIKQSLVNLNLAYNNLQSIGNNMINDFNQLQNLDLSNNEIMEIQSNSFTACPKLTKLIITYNHLRILRKGTFAHQEFYSMLNLAHNAIAELDYNTFGDNNVQYLDLSNNELKSIPRHALKSIQSSISTLVLKRNRIRSLDLNDFSGMNNLSELILSDNHIESIEEAAFASMPKLRKLDLSHNPELSHSIEILNLADTGLFSVPKITNRGLRNLNISLNKINELSVKEVSDHKKLAILDLSHNNLKNLDVQLFNRLSEIKCLNISWNRVEEITEKHFENLYYIETLTITNMLVLHTLPQPQAFQHLRHLRNLHLHDLPIIKFYNVSKILHYLPPLRELAIEIKESSLNNQLKDIDLRLLRKITITGKQLRKIETGAFIRLRGYKIELIVRDTSIREFPPAIFNTLTGVSFLSLSLINNLLETFQPFSYTKPPVLNQHGTILHDLQLMGNPIVCDCRLKWLNQWLEYHQGIQQHLTISKNGIKCINTNNQLSNTAFKTVLLNYSQTSLKYCFKTDNNQADHRFHGFNLYFIILTIVTGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJD7</accession>
    <name>A0A0N4UJD7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylyl cyclase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1964</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000039">
        <property type="protein sequence ID" value="VDN51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJD7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJD7"/>
    <dbReference type="WBParaSite" id="DME_0000776701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000776701-mRNA-1"/>
        <property type="gene ID" value="DME_0000776701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="251"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000776701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44213" checksum="483FE93E007DAC9E" modified="2015-12-09" version="1">MMATAVDIERNFIWIAAGKEEPTAEEKQQMLSPMFDLIKEVSQMAESKRKETTSNHISAVSDGIQIFGWLIMKPAVISYVNDMIDAATFFANRVMSDYKVDNKNPHSNWAKALLEVLNAIKSYVSQYHSKGLIWNTDPGASPQKSVSSVAAPSGLSQSPVASAVLPPPPPPPPPLPGLKCGTDNANVDRAALFAEINTGENITRRLKKVTADMQTHKNPALRAHIDETKFPKINEILRPSSVANKIDVEKTTKAKTFLENGKQWNIEYHKNNQNIVVEINDMKQTVYVFKCENSIIQIKGKLNSITLDGCKKVAIVFDSLLSQVEVINCQRMKIETRGAMPTLSIQKTDGCQVFLSKEAMSNAEIITSKSSEMNILVPIGADGDFVIFFDSSHKMMRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJJ7</accession>
    <name>A0A0N4UJJ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10206</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJJ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJJ7"/>
    <dbReference type="WBParaSite" id="DME_0000783601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000783601-mRNA-1"/>
        <property type="gene ID" value="DME_0000783601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="11"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000783601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53886" checksum="E9A6955EE260A6DB" modified="2015-12-09" version="1">MKSIWNSKRGLGWIVTAFFIAADMVGGGLVAMPVAFLNTGLVMGCFIMLVLATLFAYTAYLLGINWVIMQERWPEYQEHCRKPYPEMALRSMGTKMKVFTSFIVCATMFGTAVVYILLSTRIFQSFLGSIFDVQIPFCLLLVVVTINIMPLAYLKSPADFWFEFSIDVNLEKTNEMLVVIISLGCTVLAILMSIGGIAVDTPACFPEAKYPPLSIWETLYSLGTFFFAFSGHQVLPTIQHDMYRPKEFTKSVILGFIIISILYMPISIYAFLVYGDSMSGSVMDSIQTPAVRHVANISIALHCILALIMMANPLCQQAEDFFNVPHTFGLKRVVVRTSIILAMLFMALLLPNFGPFMNLAGSITNLTVCVILPMLFNLYIEASVVDRKNGQYKIPSFAEIVNRTNKAKLAVSTFIVVTAIFGTILCVYLSLKEVLTVRFTPPCFFSSFDSRQFGENFDTHHIRCCGSERNILSIVNSTGVCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJT6</accession>
    <name>A0A0N4UJT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2065</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJT6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJT6"/>
    <dbReference type="WBParaSite" id="DME_0000794001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000794001-mRNA-1"/>
        <property type="gene ID" value="DME_0000794001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000794001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53464" checksum="A2A392D398175225" modified="2015-12-09" version="1">MNYRSIYFANEEDSTNYKNELSNRAKWLRSLVLKAVISSVNMRLAVKTYHSSGHSYIAWERCNVSIGDSFAYSKLFNRTTEGEDSGYSISPILHGNIPRMWEMIESRPPNEGINIRVCSYNVLCQNTAMQHEVMYTHLSKNASAYALQWSYRSSLLAYELLRINADVICLQEVQFDHFDSFYKPLLIDAGYFCEFKQKTGSFIDGCAIFYRSKFDCLKYIPIEYYLDENCVLNRHNVGMHIYLVMNTNLVICRNNVRRQIMRLKDKQSGAEFCIANTHLLFNMKRGDVKFAQLVILLATLDKECGPNADKPSPLIICGDFNLPSGCPIYNFLLGHPLLLAKFCNARLVDQYAKHSRHSSYDIISEKLKIGQNCCFFENIDKTVQSSNEFRTHSFKLADAYASLVPQQDRRNNLMRARIFESRLHLYRRLTLPTLNSLHSTSSPWPNATTPSDHIPLIVDFILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKA4</accession>
    <name>A0A0N4UKA4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10275</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKA4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKA4"/>
    <dbReference type="WBParaSite" id="DME_0000813901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000813901-mRNA-1"/>
        <property type="gene ID" value="DME_0000813901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="69"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="180"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000813901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46006" checksum="D640D0AE954F8C89" modified="2015-12-09" version="1">MFHSSPLYIIGGRAFVFPIIQMVQRIPLNTITLEVISPRVYTQKGVPISVTGIAQIKIESRKKEILAIACRLFLGKTEIEIKQIALETLEGHQRAIMGLMSVEEIYQDRKKFSEKVFEVAKCDLINMGISVVSYTIKDIRDDHGYLKALGMKRTAEVKRDARIGEAQATRDKIIKVMEVAAEEQRMIAKYKNDIEIAKAKRDFELKQAAFNYDVNVNKAKADFAYQLQAAKTKQNLKEENMQVAIVERTSAIEVAKEEVIRKEQELNATVRRPAEAEKFRLEKIAEAEKEKIILNAEAEAEAAKLRGQADAYAIQVKAAADAKQIREKAEAFKEFKEAAITEMTINMLPKLANKVGESMLDGVNEIKMVSTGQSDIGAAKITGEMVSIMEKIPQLMSNVTGVDLFRGQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKG4</accession>
    <name>A0A0N4UKG4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2279</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKG4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKG4"/>
    <dbReference type="WBParaSite" id="DME_0000820301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000820301-mRNA-1"/>
        <property type="gene ID" value="DME_0000820301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002244">
        <property type="entry name" value="CBN-TWK-30 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002077">
        <property type="entry name" value="TWiK family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF113">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="381"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="474"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000820301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71927" checksum="041FDCE38F85D6A1" modified="2015-12-09" version="1">MIQKFLQKLISPHLMLVIGCIVYMLIGALIFQALEEQNLKKLKAEQLDKIDSSAEKYSNRLWELVTIEEYKKNNMKVLKEMIREESKQHFDQYVDTVFTAHRTFRHGYETDAPSWDFITSFFFTATMLTSIGYGFVVPFTFSGRLFVVIYCLIGIPLTLVTVANVAKFISESIFFIHYKLWLLWMRFKNKSNNSDDDSRLEFRESEDEQDILDRVKLVRFPPIVVFLFVFFYGLFGSYIIQIKESWSYTESMYFTFISILTVGFGDYRPGPKNLLIVLVVIIGGIILTTMCMDVVGRMYLKEIHYLGRKLKTNNPFYLLREAKARRRRQAMASVLAKLARGMIFAHRNFNELTVQKKKHKLYGSHLLPDGKFMFARLPPDPPSDCQVVSTSAYSVRLAWAPSFSTDDQVTYNIRYRLKHKEGSKFRELKGIQGNNAEIMSIDSCSLYEFRITAVSRYGESKPVYLVQYTEPQLSPQHILATRINANTIELTWEPPYKRTNDVKCYIVYHTDNPNARLSDWEKLTVQGRRVVFPDLRYDWFYMFCATACFKDGQRSPLSRALFVKTDKLEFNRKYVGQSRTIEIMDSICDKEEANETAPLLKRDYISFNVRFQSYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW6</accession>
    <name>A0A0N4UKW6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2409</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW6"/>
    <dbReference type="WBParaSite" id="DME_0000840301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000840301-mRNA-1"/>
        <property type="gene ID" value="DME_0000840301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5885889at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000840301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11633" checksum="E2D14EED55544DA5" modified="2015-12-09" version="1">MLRKPTWKRYRQREKSQRSMAPLAQEDNYEGTEQKRCYFNFKKTILKSRVGKSLSRFDSRRGSTNTDLKSSTRIEGESHSAHEYTECPPHIEDEQFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULA8</accession>
    <name>A0A0N4ULA8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Selenocysteine lyase</fullName>
            <ecNumber evidence="10">4.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10422</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.16" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULA8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULA8"/>
    <dbReference type="WBParaSite" id="DME_0000857501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000857501-mRNA-1"/>
        <property type="gene ID" value="DME_0000857501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009000">
        <property type="term" value="F:selenocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF62">
        <property type="entry name" value="SELENOCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="11"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000857501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46458" checksum="0ABCCA835187F867" modified="2015-12-09" version="1">MSWYISESALIYLDNNATTPIDSRVKEIIIETLNYWANPSSNYLIGKNAKEKIEFARNQVAHMLKVSQQSVFFTSSASEANNWVIESSLRYFETIHGKDKKARIITSAIEHPSILKKLEDLKEIGKIDLTIIGIDFESGIVKLDEIDKTLCKNTCLVTIMLANNETGVIQPLARISDLIRKFNNRCNSKILIHSDVTQAIGKMKVELNDLKVDFISLSGHKFYGPRCGALVLRSENTTPLFAFLHGGGQERGMRGGTENTPMIAGLGKACEIVSNDFQLFEKKYREVRDWFEKKLKETFADKVIIHFEKSKRLPNTSSVAFSTYNGTATDLLSKCKSFVASTQSSCHSYSQRSSPILSACGINEELASRTVRFSFGRDSSIEDAEKVLNELKSIIFFSKFGSSLLNAIGKGPLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULD7</accession>
    <name>A0A0N4ULD7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DME_LOCUS2524</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24 26" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01000065">
        <property type="protein sequence ID" value="VDN52551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULD7"/>
    <dbReference type="STRING" id="318479.A0A0N4ULD7"/>
    <dbReference type="WBParaSite" id="DME_0000860901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000860901-mRNA-1"/>
        <property type="gene ID" value="DME_0000860901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF24">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="22">
        <location>
            <begin position="48"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="23">
        <location>
            <begin position="483"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="VDN52551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="DME_0000860901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="612" mass="68619" checksum="CA06DB588F6D0509" modified="2015-12-09" version="1">MHGDFWYRSYLTLHRDISGVHLLLRLKIDLNRRMAENRGLNKIFMDLVEKHSCKVAIIDIETNRTFTFAEFNCEMNKYANYFKSLGYKNGDVVALFMENSVNFVSAWMGLSKIGVITAWINSNLKMEPLAHCINASKAKSIISSVQMCQSVKEISDQKLIDENIEIFSLGNSKWNCINLCEILSSTSSDEPQNCKDVDFKSALCFIYTSGTTGLPKAAVIKHYRFYSMVTGVAHSFRITPCDRIYLAMPLYHTAAGILGIGQTIIFGSSTVIRRKFSASNFWKDCVNYECTVSQYIGEICRYLLAQPKIPEERIHKIHLMYGNGLRGEIWQDFVDRFGVRIGEVYGSTEGTSNLVNIDGKVGACGFLPISPLTSFVHPVRLVKVDETTGEVIRRHDGLCVPCRPGQTGAMVSTIKSNNPLLIFEGYLNQKETSKKVLKNVFKKGDSVFVSGDILHWDKLGYLYFKDRTGDTYRWKGENVSTTEVEAILQPLNCVADATVYGVTVPGHEGKAGMAAIVKSDEAFQDNQMFLDEIGAKILNKLPSYAAPVFIRLCKSVDKTGTYKLVKTHLQNLGYQPDSKNGHVFYKNAKSNKYVPLDSITLQLIDSAQFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULH4</accession>
    <name>A0A0N4ULH4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2564</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULH4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULH4"/>
    <dbReference type="WBParaSite" id="DME_0000864901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000864901-mRNA-1"/>
        <property type="gene ID" value="DME_0000864901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DUF3456" evidence="10">
        <location>
            <begin position="133"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000864901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="31326" checksum="9B08CD3027EDB8D7" modified="2015-12-09" version="1">MGFFLSQRGYFKETYFINYLKYLLYWKRPEYARALKYPQCLHFLEAVQSADFREALACSANAKFIEEQQMLQWQYYTRKRQRLHVSNCTFQNVQLLCLSFLILLIPIICPRTVDLPSRCESCLLFARELEELSKKNSVKDELSLIEINEELCNRMLDYKLHQEKKGIKRFSKQESSTAKAINKLRKRGVKVELGMPDEMWDNPPVEIVSLKQQCESMLENYEDDVAAWYNVKPKISSQEYLCENRILHGDELSCLKESKVGHVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULP5</accession>
    <name>A0A0N4ULP5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10461</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULP5"/>
    <dbReference type="STRING" id="318479.A0A0N4ULP5"/>
    <dbReference type="WBParaSite" id="DME_0000872801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000872801-mRNA-1"/>
        <property type="gene ID" value="DME_0000872801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824679at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000872801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12153" checksum="5AFD6389AB17EFB9" modified="2015-12-09" version="1">MGDFEKIIEMFAAFRPKSLSFFSQASKRLVHKGVDCAPPLRFYSVPERIFVFLATATVMLSYPTYVLLNLDNLRPHPVIKLNPEVEAEMERLAAKREALGNPPTPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULU3</accession>
    <name>A0A0N4ULU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10473</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULU3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULU3"/>
    <dbReference type="WBParaSite" id="DME_0000878501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878501-mRNA-1"/>
        <property type="gene ID" value="DME_0000878501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45722" checksum="5285C28566718B78" modified="2015-12-09" version="1">MIRFFLVDEWVHYIRGLLSLVIYGGRIDNIYDSNVLNAYLNSFFNESVIQSSNFELCNILSFKKSSLNHLKDYISMIEKNIPQEDNPVLFGLPANIVSSWQMIQSGTMISQLKQMQLGSDRQPKFDRLVLCTTLSPILSIWKRLNSQTTFHSMQIPEVKDSDDPILEILSVEYIFAINLVQIIHSSLSNLNKCIKGTQLPTKSAIEMSHSLLMHQTPEHWQNHWDGPNDPVQYLSTVMSKVKATKELVSTAANGHIFSNPIKLTKLFRPEKLINALRQYIARKMKVGMDFLKLAAVWKTMKKENMNSVFLEITGIYIQGAHFDNRLCEVSSSSPPFSIIPNLLITWIPSETSSYYENSNSVFIPMYTTSNRDDLIAEIQIPCEGDPKKWQIASVALFLAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULW6</accession>
    <name>A0A0N4ULW6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2688</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULW6"/>
    <dbReference type="STRING" id="318479.A0A0N4ULW6"/>
    <dbReference type="WBParaSite" id="DME_0000881201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000881201-mRNA-1"/>
        <property type="gene ID" value="DME_0000881201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000881201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="732" mass="83424" checksum="474392063D48C91D" modified="2015-12-09" version="1">MAICGHPTFCGTRMATYVQSLIGSSLNAEIRRKNWRELLKYYYSSVNDKLDGENKIDYDQLELSFIRLLPFQMILLLPTLGPMVLNPLKKTHPEEYELGRRTMIEKAVALIDDLLFYYELNKESVDTVVSLFLEIFVSVESNFYYRMDLNWTESSCGSNRKKSDDNFDTAIDYIYRLCTCNNKRLIDIGNAFIEKCHETNLSLVTLGSAILTGFRELIGHENITERIVLYFFLYRITDIENPIDRSKSLPKQLTEDALQHPYLAFFLYLFDFDIVGSNSSFHDFDQHFPHFTVASQEKMFISFLLTGHYNDVCHKTPSEIITHIVEYNDPRTNMLFDLSRHKASLRISQTMYPAMAKKIFPAIFPVADCSKSLSLFNIANVVSDFNKVLPNILTLPAPFLRISPTLMPPSDDEFQFLYPFLLEPLWIRDEKSNSVVAEQSDQFSISDSIQFDSLKEMVNNTEVESLAPELKQRLINSLPSTPELSTPNSCDEKIEKSTSSFSVCSLPNLFLASNSSIRYPSETDHINMEKKSLLNYEMAIELLKKALGTVIARTDAQKLADAIAADPTIADIVDIPFEKFPKFIDDNPTVAAAVIVGRITKNSNELPLFFELLIKMNVSVQAMEVVNKLCTQIDFPQDYLNRYISNCVQRCEDPNQSGFPQSRQVRMVCVFLSSLLRNRTWDVHPLSAELQSFGLKFSHVKEAASLYQEIIGAPQLNDANIANETTGIGNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMN5</accession>
    <name>A0A0N4UMN5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2857</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000085">
        <property type="protein sequence ID" value="VDN52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMN5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMN5"/>
    <dbReference type="WBParaSite" id="DME_0000912001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000912001-mRNA-1"/>
        <property type="gene ID" value="DME_0000912001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000074">
        <property type="entry name" value="SHaW family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000912001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49239" checksum="8AFB3788B200FC57" modified="2015-12-09" version="1">MDSENRVILNVGGIRHETYTHVLKKIPATRLSRLTPNLANYDPVLNEYFFDRHPGVFSMILNYYRTGKLHYPTNVCGPLFEEELEFWGLDANQVEPCCWMTYTQHRDTQETLAVIEGLDLDVDPPSQEEIAKKFGWEEDYYSGSLSKWQRLKPKIWALFDEPWSSKYAKVVSCCSVFFVIASIISFVLKTHPAFQIPSITVYDVRLDDSDYHRYSHMITTFKQYTTSHPFFFYIDLICNVYFTAELLARMIFAPSLNRFIRSPITLIDLAATASFYLDWLTITFVEPEESMDSVDFLSIFCVLRLFKLTQHFSGLKILIQTFKASAQELLLLVFFVILAIVIFAALVYYAERIERNPHNQFTSIPAGLWWAIITMCTIGFGDMVPKTYLGMLVGSLCALMGVLTIALPVPVIVANFSNLYSHSQIYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNB3</accession>
    <name>A0A0N4UNB3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3100</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000104">
        <property type="protein sequence ID" value="VDN53127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNB3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNB3"/>
    <dbReference type="WBParaSite" id="DME_0000938901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000938901-mRNA-1"/>
        <property type="gene ID" value="DME_0000938901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823472at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF3">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000938901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14412" checksum="D7450FB81262840A" modified="2015-12-09" version="1">MFFSRNEIDQLKSYRLSDPSLLTEKLCVICQCDFEKKEQIRVLPCDHHYHVKCVDKWLRTNRTCPICRQSAASDNSDNSSTATATATATLTGSSSLSHIAVQGEDGAGIIRLNNKIIDNCREFLSSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP50</accession>
    <name>A0A0N4UP50_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3334</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000124">
        <property type="protein sequence ID" value="VDN53361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP50"/>
    <dbReference type="STRING" id="318479.A0A0N4UP50"/>
    <dbReference type="WBParaSite" id="DME_0000971801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000971801-mRNA-1"/>
        <property type="gene ID" value="DME_0000971801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="192"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000971801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="45927" checksum="70BAF0E4E66D793D" modified="2015-12-09" version="1">MDVDCFIYSQIEEQLQKDKQLLRATHRLLLLGAGESGKSTIVKQMRILHINGFNEKEKKEKMTDIRRNVRDSIEVILRAMSEIDPPVQLDNPSNQPSKEYLLTTAVSPDFDYPQIVYIIKKNNELQFFHLLSKKNFFSIFYDHVMKCWADRGVQACYERSNEYQLIDCAKYFLDKVTDIRQNDYNPSEQDILRCRVMTTGIFETKFEVEKVRFHMFDVGGQRDERRKWIQCFNDVTAIIFVCACSSYNLVLWEDATQNRLKESLALFKNIWNNRWLKTISVILFLNKQDLLSEKIKSRRHPLESYFPEFANYQLPSDASYDPSDDINVVRAKYFIRGEFLRISTAAGDGRHHCYPHFTCAVDTENIRRVFNDCRDIIQRIHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP80</accession>
    <name>A0A0N4UP80_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3366</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000126">
        <property type="protein sequence ID" value="VDN53393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP80"/>
    <dbReference type="STRING" id="318479.A0A0N4UP80"/>
    <dbReference type="WBParaSite" id="DME_0000975001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000975001-mRNA-1"/>
        <property type="gene ID" value="DME_0000975001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000181">
        <property type="entry name" value="Nanchung, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF30">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000975001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="802" mass="91970" checksum="9D2360A12574880B" modified="2015-12-09" version="1">MGNSESSTTDGEGGIRKQNDDVQNYKLYRFVDMHGGGELIPWMRYAKNSGDYSIIDEFIAAKVKEFMYNSGKGKMVAVSELVKIRNKERNAMLSALKRKKGKGKSGPNILDNFNQEGENQGDLKKALKLLEGGGKGGKGDSKYREVAWKLDERGSMGENLVGICLLQGTAVHIQLAIKLLLTYPKMVNDIFISEDYYGLSPLHQAIINEDPCMVNFLLHHGADIHQRCYGASFCPEDQKSSRTDSLEHEYVELSQNTNYVGRMYFGEYPLSFAACMDQMDCYRLLIAKGADPNHKDTNGNTVLHLAVIHEKFEMLKLAYDMGARLQIMNKCNLTPLTLAAHLAKKEMFEQILRLESNVVWMYGDASSHAYPLANIDTINQESGELNEDSALSLIVYGETTEHLDLLDGLMEDLLQAKWEAFGRRKFVVSMCNRLAISFFSFLIYYAFVFMSFMCRPFSMTTQVRLVAEPAVLLMAIFQIIADISDIRSIGKKRWWQVLKSFPAKIAYKISFLFVILILPMRLACSLSETFLLFDNILSLMTVLFTGVHFLFYSRALKFIGPFVLMIYTILSRDLSRFFMIYSIFLIGFSQAFYIIFMSCARAEAANKNVPVSNVTNIIDNPAESMMRLFIMTIGEFTIFYRSLNFCENVTMRDTGKFLFIIYELFVSVMQFNLLIAMMTRTYERISRTQKEWKRQWAQVILMLELSLKPKERLIALLKYSRPVGTDKRKRAFVVARKITSDSITQAEKQMREQQMRKMREDKRTLLKRRIKDLTNMAQNDPNKTRPLTSYIRNALASRDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP93</accession>
    <name>A0A0N4UP93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3381</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000128">
        <property type="protein sequence ID" value="VDN53408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP93"/>
    <dbReference type="WBParaSite" id="DME_0000976501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000976501-mRNA-1"/>
        <property type="gene ID" value="DME_0000976501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039579" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000976501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11498" checksum="B8CC7A047A4E9494" modified="2015-12-09" version="1">MSLLAISLIFLILSISVYTNSDEEESETSMIKIIEPIGPCINSQCPRRHICRNEKCYPNSLKAETYRSQRKLESIGPCIGGLCPKNYECFEDDQCYTVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH3</accession>
    <name>A0A0N4URH3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000270">
        <property type="protein sequence ID" value="VDN54097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH3"/>
    <dbReference type="STRING" id="318479.A0A0N4URH3"/>
    <dbReference type="WBParaSite" id="DME_0001065401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001065401-mRNA-1"/>
        <property type="gene ID" value="DME_0001065401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867360at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001065401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8677" checksum="059FB15B671C2B03" modified="2015-12-09" version="1">MVTDAAQAFGAKITGLFKKGPAYLDYPKSEPYEGRIMLTDRIAEVEQEPLEQHVSVYHIGRYDEPITGKIEFIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URX0</accession>
    <name>A0A0N4URX0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4202</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000401">
        <property type="protein sequence ID" value="VDN54229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URX0"/>
    <dbReference type="STRING" id="318479.A0A0N4URX0"/>
    <dbReference type="WBParaSite" id="DME_0001080201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001080201-mRNA-1"/>
        <property type="gene ID" value="DME_0001080201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="125"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001080201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38019" checksum="BCFC937A2EFC0AC4" modified="2015-12-09" version="1">MPSEEHTDDEPTMPKETDKPGSSSPVSKITSAGRENFLKKLNDIRTKVAMGQFSTSDGTYPAAKEIEELEEKSEESDEEEESEEELISHEEIEMPSEEHTDDEPTMPKETDKPGSSSPVSKITSAGRENFLKKLNDIRTKVAMGQFSTSDGTYPAAKEMYKLKLAQEHVDKCHYDRSEYFLKYFYGDGVGETLFANWTLENDPKDDILSVAVDEWLKSKPMGETSLLTDKYINSSNENLAQPFPDRHISFQLITARTTEIGCGVSFCEYPQHLDKNGTPRCMRVVKNAKAMRNVRRMLHQNVCHRRNTFTLKDQIHVGLKAPHEHFGLTGVVKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2T5</accession>
    <name>A0A158Q2T5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5150</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2T5"/>
    <dbReference type="STRING" id="318479.A0A158Q2T5"/>
    <dbReference type="WBParaSite" id="DME_0000079001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000079001-mRNA-1"/>
        <property type="gene ID" value="DME_0000079001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985088at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000079001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="761" mass="86384" checksum="20BFE79ED66ADF55" modified="2016-06-08" version="1">MEGKSMFYGVRTGLPLAIGLIIGVLLSLSVLNIDDDLVLLTTTKCSLASLQSPSLSLEDELSSEHWEVIVKKLTPISNNMQQQSTKFVRPRFVASELGIREKLMVIIFGQSSLSLSLNMSLAKYVPRVHIFVDAAQFSIDLSNSRDTTIYRSNGQHAHIVILNNIFNMRLIEQMEDLYDLADVFYADRNVYPDQKEIKLISWNKLVAISGYLSGNGNNDDHGCVLESGILLSYPAMKTILERRSVCNSIVMNSDYSAFEECIHRAMNRSCINHENAVGVGGDISIHDAIMWWSSSPNFNKSLSVSPLLSDSDANTLHQHFISVELDCIDREIDKLVTEIEISSYDIADGPTWPAAVSPYSRPLNRHQVAKWQYFTNVEIFKNELDQNMELLSGEDKSDILEVIAAAREFAESKSGPAFNQEFLQMRNGYRLFDPVRGMDYILDLMYLDGNTVVHRIHLVPYVKEDTDLTIVIPLGSNEEVRAVRYLLARFIRLCSAAVDDPRQTRLVVAVRGVNPSAIRLINNDIIELRIQQTMLLILKSDSHPVIAAAALDEAVGHFGDQMIYLLLSPYADIQREFLDRVFFPIPFVEFNQQIVSSYELFQRALKDGFHKKDIAHNKGKDNVDGSLVKNSLRFSAILRNSQYKSNRPAVVHKDQGHFDISDYSILSIYGLDFLEFRKLLPEKVLRFDLSSLFLNQSDIHILRAIEPSLRLHYHFRSCDILLPKSEYFRCINGRRENIATKAQLSNFFFSSQDVDDIIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2V1</accession>
    <name>A0A158Q2V1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5255</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2V1"/>
    <dbReference type="WBParaSite" id="DME_0000089501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000089501-mRNA-1"/>
        <property type="gene ID" value="DME_0000089501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="114"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000089501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43939" checksum="2F3BD4AEF698F982" modified="2016-06-08" version="1">MQKRNTSVNHGNAKMQKESRVDCRNAKKRGKSKSWTAEMQKKGKSVNRGLQKCKKKGKAAKAKSDITRTVGCLIRNFEFSEKWQARDIGKIPASAEVSLVILITIMRRSDPLVECGTNGFNVKLPMDEAFSGHVFIRGHYGHSNCHKDYRLMSVMEPAMYVSFDSCGMRRKRQANPRGLSVSSTIVVAFHPKFITFNDRAYQIECFYLEENHLVQSDVFVSPLETTQLVIQQKMPICRYVVLEGGPKGNSIKSLNLGDIIYHKWSCEVDEKAVYCMHLHSCTADDGEGFIQAIVDADGQIEYSNDLAAGVLMKAFKFADKASVSFQCQVGLSLKEKYPKSVCPKPNCKSRIRRSYDQPDFYIDIDSNRLSVSELNLQPIKKCSELDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2Y6</accession>
    <name>A0A158Q2Y6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5486</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2Y6"/>
    <dbReference type="STRING" id="318479.A0A158Q2Y6"/>
    <dbReference type="WBParaSite" id="DME_0000112601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000112601-mRNA-1"/>
        <property type="gene ID" value="DME_0000112601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000007">
        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF85">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000112601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="626" mass="70945" checksum="74CB6FA1F52899F1" modified="2016-06-08" version="1">MFRKIKTNRRSKIRLETVNSRQARLMRCKRIQNDPRNTAEILIREKLVVPLEDTSGRHTMSVDEVIRSNIANACVPRLDEAECERSICYNLYYRTFDGTCNNLQQPLRGAAFRPYNRLMPPEYDDGLSEPVSFTRQFRPSPRALSRTILASRKTVHHPEYNALMMQWGQFLTHDMAKTTLVPSAKCNVCKNITDLCMAIPIESTDPNGIFKKGGCIRVSRSSAICGSGNKKPRQQLNENTNFIDGSPIYGSSIKDNEKFREGRTGFLKLQKFNGMNTLPFDAKKCENKEKCTVIFLAGDSRVNLFMGLSSFHIILAKEHNRIAKQLQSLNPHWNGDRLFMEARKIVGAQIQAITYREYLPKILGSSFASTVGEYNGYDANIDPTLANEFNSGAFRFGHGMIQDFYPHLNSNNQNTSFGGYQFGEGTLRSDLLLFEGGVDPVLRGMMLTRLKRPQRLTPAVTEKMFGNTDLGTINIQRGRDHGLPPYVKFRHLCGMTPATSFHHFAGEILSTKARDKLKSMYESPDKVDFFVGAMMEDPVVKGLIGPTLACIIGPQFQRLRDGDRFYYENPGIFTRSQLKEIRKSSLARILCDNGDNIESVPREALRIGPLIPCSQIPQMNLTMWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q342</accession>
    <name>A0A158Q342_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5964</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q342"/>
    <dbReference type="STRING" id="318479.A0A158Q342"/>
    <dbReference type="WBParaSite" id="DME_0000160401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000160401-mRNA-1"/>
        <property type="gene ID" value="DME_0000160401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF2">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000160401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="627" mass="71319" checksum="7E63093B6D36448E" modified="2016-06-08" version="1">MSDNDKFCWLSKVYIITAKTKSVLLLSTRRRFFQIIETKYFEPIFIVNLTGYGDLQSYGNPNQEWNEIDEMIREGTRFTQAYSADSMCSPSRAGFMTGRLPIRLGITGGARVFLAKDAGGLPKHEETIAEMLLKYGYSTGMVGKWHLGINEVNQTDGSYLPSKRGFQYVGINLPWTNVWECDVSKKFVESPNATLCFLYDGDKIIQQPIKFEHLTEALVNDWKRFLDKQMKTDIEKPFFFYFSFPHVHSSQFANEHFINSSIRGLFGDNINEMAWAVGQVLQSLRNYGIERDTLVIFMSDHGPHQELCLNGGSTAGLKGGKSNSYEGGFRIPFAAWMPGTVKAGLVSREVISSLDLFPTFESLASLGKVKRRTPGLYDGIDVHEELFGRSNFLVGFRNSNFSLAHRRPIFYYCNTHLMAIRFGDYKVHFKTSPIFRNGSNSDRIEELCPGGKPIDDWYVSLTCPEEHLTTHNPPLVYDLNEDVYEMYPLHNAHQQVQEIRMNAIRLKKEHEKTIIKVREQLGNYKLSVLPCCNPPRCECDLLTNARMGIKASLGPKRFISPIDIIEMHFGKTDAIDEVGSGEMENVENYHSHANSKSLYERLISNYNDKGRIESLKKCDIIGIGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3K4</accession>
    <name>A0A158Q3K4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6947</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3K4"/>
    <dbReference type="STRING" id="318479.A0A158Q3K4"/>
    <dbReference type="WBParaSite" id="DME_0000258701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000258701-mRNA-1"/>
        <property type="gene ID" value="DME_0000258701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001370">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="80"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="401"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000258701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="637" mass="70863" checksum="1EA968F2FED16F96" modified="2016-06-08" version="1">MPKWYVTWKKYCNVSALILRLVHPRFISSFIEKIEAIEEPNDQYYCRRDLAKRKLSSKPVSLSELFRYGKPFDKMLMFCGVIFAILSGISQPLLALIAGQLTNILLTVQPTSAEFKVRAYQKVFLFLGIGCFLLVINYLQYICFQLTCSRIIAKLRHAFLKSILRQNASWFDKNQSGEITTRLNDNIERIREGIGDKLGLLIRGLTMFVASVGIAFFFQWRVALLMFGVAPISCFITSSLSIKMGSATQKELKGVGRAGAIAEESILGVRTVQAFNGQSEMIQRYQADLIDGKKFGIMKGYWSGFLGGLFFFTLCMFLGAGMLYGGYLYKIGIFKEPGEVFIVVMSMLLGSYFLGLVSPHLMVLLNARVAAGIIYQTIDRIPEIDPYSTRGVIPNNIEGKVIIKGIHFRYPSRKDIKVLNGVDLIAEPGETLALVGHSGCGKSTLFGLLNRLYNWESGTITIDGYDIRKINIACLRNIIGIVQQEPIIFDGTIDENIKYGNPNADEATIHEVCKMANAHGFIKMLPKGYETRIGDGGVQLSGGQKQRIAIARTLAKNPKILLLDEATSALDAQSESVVQEALNNAVKDRTTIIIAHRLSTIRDANKIAVFEKGNIVELGVRLRRPSVQAKRGADKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3U4</accession>
    <name>A0A158Q3U4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS7371</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3U4"/>
    <dbReference type="STRING" id="318479.A0A158Q3U4"/>
    <dbReference type="WBParaSite" id="DME_0000321201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000321201-mRNA-1"/>
        <property type="gene ID" value="DME_0000321201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF829">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN57398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000321201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31304" checksum="DD9E0CF27CCB3AE7" modified="2016-06-08" version="1">MIWRDGIIPYEMDSVPKEIKLFEEVFEHYRRNTCIRFKKRKAENDFLYITKGTGCYSQVGKAGGKQELSLGRGCLFYEIITHELMHAIGFWHEHSRTDRDDYIRILWENILPGMEPQFDQISAAVQDLLGEKYDYRSIMHYDSTAFSKNGMNTVETIENGFTEIIGSALELSELDIKKINKLYKCENNNSNSNEGPATSSLESSSDPPGINFSNFNESANSNRFLFFPLLKFFSECFDHFSDCKQFQENCNRPAFFFVMKTYCQLTCGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q477</accession>
    <name>A0A158Q477_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NF-kappa-B inhibitor-interacting Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8071</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q477"/>
    <dbReference type="STRING" id="318479.A0A158Q477"/>
    <dbReference type="WBParaSite" id="DME_0000418801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000418801-mRNA-1"/>
        <property type="gene ID" value="DME_0000418801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10002389at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000418801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22598" checksum="C61D0559159201F4" modified="2016-06-08" version="1">MGRVMRVVVAGTKKVGKTACLQQIACLNDITKQPYVPTIDDTYQIQMDYGEHSKEIVVFHDTAGISDCGAAELKKPYIQVADAFVLVYSVTNHETFNRMDLLKKFIEKQFGKDKKEVPIVVLGTMIDLPNRKVNSDFAQSWATREKVKLYEVTAGDRSTLIDFVTYLGSRYFHSQRELKFSLSKKFKPEKSNSAIVMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4G3</accession>
    <name>A0A158Q4G3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS8672</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4G3"/>
    <dbReference type="STRING" id="318479.A0A158Q4G3"/>
    <dbReference type="WBParaSite" id="DME_0000478901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000478901-mRNA-1"/>
        <property type="gene ID" value="DME_0000478901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="267"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN58699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000478901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53147" checksum="9FC7A94E5D77F2A3" modified="2016-06-08" version="1">MIGAEHLLVFVCAVLSPIVVLFVTLLFVFSSLINFFGLRKKYVQSLLKIFKWSARQIHSSEGLRQDGSEREFSESNSDCDEELNSAKLSMFCRKRRGSGIIQRRRSLDLYEEGNEIRFVRSRGWATVDDSLEFVKHGIEVIIQDDVTNRFEAEQLATWNMLTRTSISFYQHINWKVTLLWGAGFLFRYLVLLPIRLIFLTSGLIFMVVSTALIGFLTDGPLKTWLNKNCMLCCYLILSGSVTAIITFHNEQNKLAGSDFGPIRSIPGICVANHTSPIDVAILGIDNVYAYVGQRHGGLLGFLQHTLSHASSHVWFERDEERDRLFVAAKLRDHVNQPDKLPILIFPEGTCINNTSVMMFKKGSFEATSVIYPIAIKYDPLFGDAFWNSSEQNWLEYVFRTLTSWAIICDVWYLKPMHKLANENAVSFANRVKKEIAECSGLVDLEWDGGLKRTRVPAKMINENQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4L5</accession>
    <name>A0A158Q4L5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8967</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4L5"/>
    <dbReference type="STRING" id="318479.A0A158Q4L5"/>
    <dbReference type="WBParaSite" id="DME_0000516801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000516801-mRNA-1"/>
        <property type="gene ID" value="DME_0000516801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="337"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000516801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52000" checksum="69F07747EA870EE2" modified="2016-06-08" version="1">MAFLEQINRIACIGAGYVGGPTCAMFAYKCPDLIVTVVDMNSEKIDQWNSDKLPIYEPGLDEIIKACRGKNLFFSNDIAGAIREAQMIFISVNTPTKTYGKGMGMAPDLKYVELVSRAIAKYAGGTKIVVEKSTVPVKAAESISAILREAQKRDSTLSFQVLSNPEFLSEGTAINNLANPDRVLIGGEDSPDGLAAVAQLVQIYEHWVPRERIITTNTWSSELSKLAANAFLAQRISSINAISAICEATGADVREVAHAIGYDSRIGKNFLQASVGFGGSCFQKDVLSLVYLAECLNLNQVADYWSSVVKINLWQRRRFVDKIINDMFNTVTDKRIAIFGFAFKKNTADTRESSAIYVSKYLLDEGAKLVIYDPKVPKNQILHELHQVCTEETASKLVTVAADPYEAAVDSHALVILTEWDEFRDYDYRRLYNSMKQPASIFDGRLIIDQKKMREIGFRVFAIGSTSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Q1</accession>
    <name>A0A158Q4Q1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9153</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Q1"/>
    <dbReference type="STRING" id="318479.A0A158Q4Q1"/>
    <dbReference type="WBParaSite" id="DME_0000535401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000535401-mRNA-1"/>
        <property type="gene ID" value="DME_0000535401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5806782at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000535401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37975" checksum="29D854D3DB1CB0CC" modified="2016-06-08" version="1">MVLICKNSEEQIVEMAAAKPKERQFQVVPVPGKFTRGRWKCWDYRDEVKEIGEILDFTEKDKSAPPGEIKLFQMMVVDENRIQSSPSSPSRPRFMRMTSVEELDSSLTLLTNCYSPKKFKPTSSILTSSQYANLKSDCFSPPSSVLCSSLNSPDFKNLLLSPTLSVDIYNNFNNQSLSFFDKNNNSSNNHKNNDNIRNNNYNNNDEYKLNQSNGSALVIATDDLVKTHLTFAVREEVDVLRSTIVDLEAKVCYFRDFLLVFFFFSIRDDAWFIYKSVKLLNCSFFFVINHYFNLVKQNQQPSFSTNIAKSFETNSTIGTNDATPNPSATNLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q599</accession>
    <name>A0A158Q599_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1485</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q599"/>
    <dbReference type="STRING" id="318479.A0A158Q599"/>
    <dbReference type="WBParaSite" id="DME_0000687101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000687101-mRNA-1"/>
        <property type="gene ID" value="DME_0000687101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872806at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044470" evidence="4">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000687101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40475" checksum="56263FA24DC72FF9" modified="2016-06-08" version="1">MLYSAPLSIFIVLCGELIYWVNCSIEKVNGSVKQGPSSVRIGMVINSVDDIDFKKSILKISITLTIILQKSRRAPGSLVVNHNQYQYPFSDIQLSSIRTERRDPNRVIKTSTDGTTSSISKYGLEIHCPFNFKLYPFETHNCAVSVFTSRFSIEQMTLSWIDAKDIQPSQNYISSGARISMNRDENCDFDEIYSNAELNIKSGNHLGKDAWTDGSVAAARTLYNKNCEMERNAAGNFIETGHFKAYLGNFIIICHLNHLKLFIATRELPSTIYITALDVWTAICFCFLFFTFVEMIVVYMLMKTSQKYWRLTNKNDSIRKESQYRQEKLAAKSCTLEKSVPSASNGRNRENKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5A4</accession>
    <name>A0A158Q5A4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tho2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1514</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5A4"/>
    <dbReference type="STRING" id="318479.A0A158Q5A4"/>
    <dbReference type="WBParaSite" id="DME_0000690001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000690001-mRNA-1"/>
        <property type="gene ID" value="DME_0000690001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000690001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17887" checksum="767331D7678BA298" modified="2016-06-08" version="1">MLCEIEKVWKKLGYLSVTDAMSGFVSLLDSVCPPFRDFINDYVQSQKKNSERVIDIESEKNKGLFILTNLKQVFSNVAGFVSPVIFVQIYRQIECADKHFDAQQQSRGPSVYDIERYDAQRRQIQEALNQQTHHQFRAYAQQQFVGDLVQVNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5F8</accession>
    <name>A0A158Q5F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9916</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001195">
        <property type="protein sequence ID" value="VDN59943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5F8"/>
    <dbReference type="STRING" id="318479.A0A158Q5F8"/>
    <dbReference type="WBParaSite" id="DME_0000724801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000724801-mRNA-1"/>
        <property type="gene ID" value="DME_0000724801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000724801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43499" checksum="F3CA0F57A8A4C0FF" modified="2016-06-08" version="1">MRSDPAVLFLMKLSPFARTIIVTSGAVLIHLSLGTYHTFGNMLPYMASFMKNFTDSSISEEKLIWIPNFQGCFPFAMVIGGSLNSRTNARVAAFVGCFFMTLGTLLTFWTIQMSFSLFLITYGIMFGLGQGMAYVITMSVAINWARDHIGLISGIVAAGFGISSSVFTPIQTLLINPMNYKPTKSGYFTEKELTSRVPSVFYILAIIYTFMQLLGLLVICDPPDVSSSADDQRSDDNNNDDDIIPPGLAKAADNRSMKTIDVTYGETFIDDDIFLAFAFSACSFLNAVARIGWGFLVDRIGFQVEVVCIRIILLFYLVCLAFATFLATLLLISMPLASFGGKWMYFIWMCSMFICMACTHASFITATIRCFGTKNKSLNYGFLILSTTYITAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5M9</accession>
    <name>A0A158Q5M9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1978</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5M9"/>
    <dbReference type="STRING" id="318479.A0A158Q5M9"/>
    <dbReference type="WBParaSite" id="DME_0000778101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000778101-mRNA-1"/>
        <property type="gene ID" value="DME_0000778101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862433at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000736">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000778101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50872" checksum="A8CA039DDFDE700C" modified="2016-06-08" version="1">MNIACDNECTSGLLDDIHLENNFGDGDFYDSSIAFDIHPICSDDFLLNVEETITSTENLNNLNDFVYLDGLNNGSFSCARTLNWTKNSRTNTHKAVSPIKNDFGNAKQLDIDEYADIQDFVSRKLDVHRIESRGNIPSFKSCGPWKQRRVQIKTIGGEYEANVWVAGNPHGRANVLSSTIVKSQKSCNGSLFHWDLIDLEANHSMKEMLSKIREPNLTLAETNISNNETPVISNSELNLGLIRFSRSSDLMRTTDKNVDDKHNAKIDREKFQKASNRLCEFKFSKNRRSNPQRVAKSVRMIKLHRVQDNFSSVEKSSLKKVPCPFENCNKLFKNCAALRKHVIFHRPPSHVCLDCGRAFVERSKLRRHQLVHTGEKPFQCNFEGCGKRFSLDFNLKTHQRLHFGDKPYLCSHCEKTFAQSTNLKSHLKTHAKRKRFGLDFRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P7K1</accession>
    <name>A0A3P7P7K1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein JTB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS1557</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the JTB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P7K1"/>
    <dbReference type="OrthoDB" id="5971907at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.220:FF:000001">
        <property type="entry name" value="Jumping translocation breakpoint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041">
        <property type="entry name" value="JTB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041:SF3">
        <property type="entry name" value="PROTEIN JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN51584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="106" mass="12635" checksum="AF6866D9B5563B0B" modified="2019-02-13" version="1">MNEYLCFEREKFVLIQECIPCSAFEIKALKTPYCEATGYYDKLNCTSSRKLGYKPCYTKIEHINKNLFLFTIFSSGMTIFSYSFVSWRRSVLERRSYFRIRQQIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PCB1</accession>
    <name>A0A3P7PCB1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PCB1"/>
    <dbReference type="STRING" id="318479.A0A3P7PCB1"/>
    <dbReference type="OrthoDB" id="5875724at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="276"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="587" mass="67766" checksum="347819A6989668E4" modified="2019-02-13" version="1">MLKSQDNCSKPVKKKRLCRRGGILAVGHFLNFCTYQHVKVATRYNTILDVVLATPTSLVDSIRVLEPFCKIDHNIIHASLKLDRYSPPSRFSRSYRHCNYEIFNSILAEINFNFLNSNILYLIDQYISLRKTNPLRSIPTFQKSFKKIVKKLYNKYQLTKLPNDLSAYKESLKSFRSAIHNYFLNKEEQLLNIDRNSFWTYIKRKFSNPCKQLILQHNDNVITSDIDIANVFNQHFSSVFTKDNTHISCFNIEITLLDVCDALNRLNLPLFLIYKDIMKSGLNPKIWKLSHIVPIHKKGSTYDASNYRPISLTCVGSKVLERLICNKLLIYLDHGFCTKKSTSSQILANLSDWSASIDNGKIVSVVYLDLAKAFDTVSHSKLLVTLNSYGITGDLYNWVSDYIKDRYQAVYVNNTLSDMIPAKSIVPQGNCIAPLLFLLYINDITTVVINSTIYLYANDCKIYYSHGRTDSLSPLQEDLNRIADWLYDRQITLSFQKCSVLHINSKRFDLPNLFINGNLINRVSHISDLGIIMDENLDFDLQICRTIVKKSSRILNFIFRSFRTKLKVFLSNYTKHSFGLFLITVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PEJ7</accession>
    <name>A0A3P7PEJ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000669">
        <property type="protein sequence ID" value="VDN54334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PEJ7"/>
    <dbReference type="STRING" id="318479.A0A3P7PEJ7"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="410" mass="46284" checksum="87EFEB598738ACF4" modified="2019-02-13" version="1">MAKKGILCKNEAEMRAYDVLLNLDDSSILRQILTYRREMRESMQVKFALSLFSCFKNGNYIRFFKLLKRNASYLQCCLCHRYFYDIRNRALYVMTFSSHKNAKYPIAKLVDILGFDSVSDATEFIVNYNMPVDTASESDDIYLLFSKSKFCLSATRVPKMSLWIEEKRSNTPIAQILSGGSSSEVILKQPANSFNEQGIYTSDPVISDYIENFEVENDKSRHGNVVCDSTIPDLQNKIKKSDENMANMIDSLANGIAAIVIDKEIGNIFAESMNCNATVLQTSAHLYDGVLDNCIQTQIGEVSLSASLSSNQSKKENIAQEICFENNISQNLLNVAEEKIVGDRCATVVNRNKLRNDRKLLTNLVDSISGSFYEKLMENVADELVKEIGNSVLKQEIENVQKQIAARLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUU1</accession>
    <name>A0A3P7PUU1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUU1"/>
    <dbReference type="STRING" id="318479.A0A3P7PUU1"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="64"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="259" mass="30081" checksum="DB205938537F6E74" modified="2019-02-13" version="1">MPIGFIFEIFSILPQFFEPFSQGWNWRAFLLFYLVLNGYVNVYKTKVFGPNGKGSDLPAVIKPGYHYCHFCQLNAPPRSHHCPVCDKCIFRRDHHCSFIAECIGHFNQRFYIPAVFNFLVASAIILTWNWSYMWLSFDGISVLMLWQLIVPHLALIFRVITFSQFLCVLLYVSSLVVFLFLFYLASAQIFCLYRGQTRVEYLMDIHAYNVGFFGNIRQSLGQRWPLILFIPFILSPLQSDGLSFATKNMESINDSAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXJ7</accession>
    <name>A0A3P7PXJ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXJ7"/>
    <dbReference type="STRING" id="318479.A0A3P7PXJ7"/>
    <dbReference type="OrthoDB" id="5868801at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="270"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64262" checksum="A2FE07FD45D2B2DF" modified="2019-02-13" version="1">MKDPSKAHFGQEDYPKLNDGKAVYIGVHKSATFVEGPKGKGSKFAAIVVDRCKKRIIFRISGVSAKSARTESFEYSGETLTIEQYYHKRYNIQLQYPNAPLLISKKSQNTCLFPMELSYVIEGQRVSQEQQTPKQLISMRTACIIPPAKRKVQNDKNVEAIHLLDNNNQWVARAGIDVIKRPLQVDARILPNPKILYGYGNASQVDPEKWSFGKNRFRRAATITTWAAYEILAIRGNANRRCSSDLIKAMERKYGIVTQDIKKSIASAVINKGKWQTMENIILKTNIKMGGINYIILGDEKPDRLIIGLAMSHPTDGINPSNANGVTTVGYAANTGESQLEFIGDFSFQRAGSTDVCSFFIYFIFRILERYVKQYNCNPSEVLIYRSGISEGQYKMALTMEIPLIRKALQMCGCPELPITYIVVTRLHNIRFMPPKVCGLNQNIRPGVVIDKQVVHPKFKEFYLNAHKTLQGTAKVPRYTVIVDDKNMSMDELEVLTYSLCFCHQIVTLTTSVPTPLYIAGLYADRGRRLMWNISGNSGNTRGPIDLEKLNQEIPYEWSNLKTRRINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q1V9</accession>
    <name>A0A3P7Q1V9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q1V9"/>
    <dbReference type="STRING" id="318479.A0A3P7Q1V9"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="79" mass="8841" checksum="7646E4593DAB63D5" modified="2019-02-13" version="1">MAFSPNRYWLCAAVGPVVKIWDLEEKKPVDELKLDVLSNNKAGPAQCISLAWSADGQTLYAGYTDNVIRIWQVSVAQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QVF8</accession>
    <name>A0A3P7QVF8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QVF8"/>
    <dbReference type="STRING" id="318479.A0A3P7QVF8"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021939">
        <property type="entry name" value="KN_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF21">
        <property type="entry name" value="KANK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12075">
        <property type="entry name" value="KN_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="491" mass="55130" checksum="56DAAF67E7A13102" modified="2019-02-13" version="1">MSMTSLNDRRYYQNSNTSQCNCCPYGFHIELDFVKFAENISKGNFDKQVNIYKLNVIFRYGKWNDSMRIEMVSIGTSTPPLLPLKRCVECLKMKQQIDSLKTKSEAVSEGVESVEELSKRQRTADDYTDNAKVLGSARAEAIKKLLTDKCDQSGDRSEKQTFKRSTKLSKSYRVPKNKGDDLQYIVGSIFRKFFTASCPSTPQTNKGALKEKVVLKKETVIKMPPSKVPEPVPARIPRPKFSRYSPAEATPQSPDEVSLKIDFIFELEWAVKYVQHQWLKTTARKTSSPIQVKGFIDAVKEISISILNYIVNITDQNENTALHYAVSHGNLDVVSVLLDTKLCDLNFMNKAGYTPVMLAALYDASDEIKLTVIQRIFEMGDVNIKANKHAQTALMLAASHGNVNTTRILLQCNADVNIQDEEGSTALMCAAEHGHKEIVKLLLKHPTIDASLSDCDSSTALSIAVENGHRDIGVLIYAHLNYTYNDRFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QXR1</accession>
    <name>A0A3P7QXR1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QXR1"/>
    <dbReference type="STRING" id="318479.A0A3P7QXR1"/>
    <dbReference type="OrthoDB" id="5795793at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="270"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="450"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="647" mass="73819" checksum="8CFD4C7B70805408" modified="2019-02-13" version="1">MEGQLKSPGFPVKYCNNLDCSYTISGANGKSVHLSIVSFETESRHDILEIRETFVVASKEYSALISVYHLWIYEFFFYRIISVKMIIIQLLLSGKDVGWPLFVSSPGNGYNLRFITDNSEEFGGFHARFARVNASRPGESCPRLFYEAIAEEQTLPTPSRKFRYNTGCVYMINTTNDNAILLQIKALSPFVKLTVYETENFDRHSQAEPLATISGLITALPYNLTSRTVSITVIMTLTRSHLEYHRNNASDHFNVVFKRTESLKFLFAACKCFAKNYLIKKNPIIITSPGYPLEYCDNLNCMTTIEFDKGSYDQTIRLDVNAFSLEHGFDFLHIYDRLLQPKYLIRKFLANFKILECRCPGSAQPLQFSTKSGQFSFDIPPDCSYLDCFLHFTKPILASINFEPGIKIAGSARIVNNEPMGFWYHLASSDNNSQIASFNFTYEWRKICQCGQSKLIANSEQSKILSSPDYPEYYCNMMKCNYSIIAPAGYIVAINITELSLETNEDFVAFFDGPSANNTRLRILILQRVYYEQMELYCRATGTNVYEPLIKSTQPEMFVYFESDVSIVNKGFVLYYYAEPLSGTLMQGDRPSSGISMSNILLAFTCLIFIFVIVVTYQKRILCFARKYGWTGASTVGFRNLTYNIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SRU4</accession>
    <name>A0A3P7SRU4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000117">
        <property type="protein sequence ID" value="VDN53279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SRU4"/>
    <dbReference type="STRING" id="318479.A0A3P7SRU4"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03030">
        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF15">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="104" mass="11993" checksum="B7ECCC9178194B93" modified="2019-02-13" version="1">MMTLTVYIASITGNTEIRKQVQRTLMILDGLGVPFKTIDITLRGNEEHRKFMRENANNERCDGVPLPPQFFLDDKYLGNYLDFEEAVEDNLLPEFLQLVPPVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SU96</accession>
    <name>A0A3P7SU96_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SU96"/>
    <dbReference type="STRING" id="318479.A0A3P7SU96"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38785" checksum="B5D7645CEC3A51BE" modified="2019-02-13" version="1">MMMLVQFFLIGFEFLILLNIYFLFSFLRYINSFISHSGNLPEGSRRKARDKLLLRLQDHIVDINAIVRSRVLQLWTRLARNFQIPLAFINGGLIRDACSRLIDKSINVRKNAAIFLTAVLQYNPFGPSDALFFALEMEKCLSTILRSIASSQASELAEIIGFIVETNKFSIRNSENAVREFFRAIWRYDSAAKEIIIKAAADLFISANKNREICAKKTAENLIRIILNVPEEERISVEEVYFVRGTVADLSKCIIDSSINVANLSKFFFSELSKKVCYRLLWISKYKQADSLVEKLCQRLQSTTSQLVFIFFKLLYSYFKNRISDNKIFKFYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SUS8</accession>
    <name>A0A3P7SUS8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000428">
        <property type="protein sequence ID" value="VDN54249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SUS8"/>
    <dbReference type="STRING" id="318479.A0A3P7SUS8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF288">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18729" checksum="97B8C6C599CDFC1B" modified="2019-02-13" version="1">MLRVSNRKKRIILITGSTDGIGRQTALELAAHHTNFVIIHGRNAKKCEAAIDYIIKENKLENRSNLDYVVADFSDLYEVAKMAEEVEERFPGLNVLLCNAGVLLPKRTESRNGLELTFQVCICFGSSLANTLLLIRRQCLLKENEMVQSVAVQFGALMLKLYSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0L9</accession>
    <name>A0A0N4U0L9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4464</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0L9"/>
    <dbReference type="STRING" id="318479.A0A0N4U0L9"/>
    <dbReference type="WBParaSite" id="DME_0000010401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000010401-mRNA-1"/>
        <property type="gene ID" value="DME_0000010401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF136">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000010401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36723" checksum="57DF5780ECD78D06" modified="2015-12-09" version="1">MADSSCNETCSALQTTDSTSFTPATRLTADLVEIMIYIICLCIGGPLNLISFIRSYRNYISDRSRSQILLLRLHLNIADLLTMFIYTPTQIIWMTTFQWHGGDLLCRICKFFYTFSFYLNSFVIANIAIDRAYTTKSIRSIKASEIALERVRRTLIIVYIAATVFSAPQLFIFQLFHPIEFAEFKQCTPVWTIYAYEYDRKLLSPTVSEQEKQQYTADFIQVHRWEMVYNMAHLLLVFWIPTLIVASSYKAKRQATLILVAYLSLWSPYNIMALMNMFATSSETRDTILVTLPFLNALIVVNPVVNPIIYGLFESNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M6</accession>
    <name>A0A0N4U0M6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Complex I-MNLL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4472</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0M6"/>
    <dbReference type="WBParaSite" id="DME_0000011201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011201-mRNA-1"/>
        <property type="gene ID" value="DME_0000011201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5784773at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8282" checksum="290BA5A5B98D55B8" modified="2015-12-09" version="1">MGTFTFSYFFKKTIWERKLHFVSFSTVFILGYCWDQSAYERAKLMKGHSKLFANRISRIPKDQDVWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U128</accession>
    <name>A0A0N4U128_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4643</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U128"/>
    <dbReference type="STRING" id="318479.A0A0N4U128"/>
    <dbReference type="WBParaSite" id="DME_0000028301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000028301-mRNA-1"/>
        <property type="gene ID" value="DME_0000028301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000028301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1102" mass="126095" checksum="5EE58F9E718C0A91" modified="2015-12-09" version="1">MSEQGSQFRMVTRGVARIQYAESAGSSLSNASAGSLFSNQQISSTTDSRDDQSEYHMDVSMDSLFRTPSASTRGRKRRFTSDDPSDAPFLSKRGRPRGGGRGRGAICRRPNVQEDADESSLFCMVKSGKNLNTVTDNWIEEYEHHPDNALVQLQQFFISCCGCKGVISSVMLQTMEYSEIIRRMTEQFDEDSADYPLIMPGPQWKKFKQNFADFIMLLVNKCKASYVFDQRLMDSVIQLLTGLADSQVRAFRHTSTFAAMKLSSALVDIAIELVSLKEKNSKQVETEKAKLKAQSVNDRLDILILKKSELDEKTDDVRQMLSYIFKSVFVHRYRDFLSDIRSVCIHELGQWMQVYPQHFLEDSYLKYIGWSLYDKVSDVRLKCLISLLPLYDRPEVIGKLELFTNKFKDRLVSMVMDKDCEIATRACQLLTGIYRVFPTVLTLKDCVPIYELVYCNNRGLAQAAGEFLNTKVFQHSQRTRNGNISGSRSHENADLIIDLIQFFIEGDCHDHAAYLVDALIDSNPMMKDWATMADLLLSGEADRFDGELIEVLVCSVRQSATGEPPVGRSHQMRKTSVAVKEHRNINEDKTRLSEVLIPQLPLLLHRLLALTFQFIADREKVANLIGIALHFQLDMYLAARLEKHLDDLMSVMESIVEKHADDEILQSVARVMSYFTMNVAVAQHTETHRLKMLDGLALQLRHSVQRFHREQQLDEEDDAAMLASFRKITAFAIFEDLKKWQLWDPTLSVVTNSDDKQISPDIREKAILLLFSTLQWDLYRLIYDQETNKIEATKKLQKHRDHFVEACTNVLNIGASGVESAFLCFADALILFCGVHIHDEILEIHLHPSTITKITDFVVDNVFVESSENGFLRSFPQGGSFGAFEKALEEINGFLNRNYLYYIFYPLDRTMDQQSQIELMHKRRNLLAVYCKLILHGILEIYDASHVLRFYNKYYTDFGDILKMLINKCRELDKLGCAKTISISLYPIKNREALAVIHKEGILFALKSEGNRRGVRPENLSFLEVLIEFSGKLIRQDKQSILRYLEKHGTDVVNEEPYVLYKASLQERNDEVSSIRNYASRGRGRGRGRGRVTPVPSVFGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U164</accession>
    <name>A0A0N4U164_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4687</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U164"/>
    <dbReference type="WBParaSite" id="DME_0000032701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000032701-mRNA-1"/>
        <property type="gene ID" value="DME_0000032701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720938" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000032701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14971" checksum="25B15D818BCD9D8D" modified="2015-12-09" version="1">MLVASYLVISFSFWQLAYTTVDQKGVCNSGEAGQLCDNEASSEECTKVIAEDPDVDKNLVSNDCFKYPTLTKMCRKKCLSCCELPEYSCSDDPATCKDTFSDCELYRNLCTDEKYMELMKKQCARTCNFCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1G6</accession>
    <name>A0A0N4U1G6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCC1-like G exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4808</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1G6"/>
    <dbReference type="STRING" id="318479.A0A0N4U1G6"/>
    <dbReference type="WBParaSite" id="DME_0000044801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000044801-mRNA-1"/>
        <property type="gene ID" value="DME_0000044801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="359"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000044801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44776" checksum="440A31E1AFF7E445" modified="2015-12-09" version="1">MKSIFGYSRRKLLSDGLVSLIYFSPKRSKSVLVCGLAASGSLYINTSPPEISSPRLAEFFKRKTVKHIAAGFGFSVCSSKNCIYGAGINIFDNLSIKNPGLHWLKSDCGGVFKIDMKEKVISLSAGRRHFLVATEDNVYSFGDNTHGQCGFDPKQLPFLLPNKDELNEPLRIPSSSKVQQVHCSFDTSFILLKSGEIFSFGLGTDGQLGRGLMNYDWKCLPFGENLNLSSEKITSISGSSDTLMAVSNGGRLFMWGQNEYGQMKAFCNKMQVHEPLEIKLDIGKVIQAASTATSCIVLSSTGHVYVWGFGILGLGPNVTCIHKPMLIDSNIFRCGLNDNGKVKDIFAGNISMFAISDNDNLFSWGVNRYCHLGLGHKKDQFFPFQVNLRSSPRSVSVAPDHTLIFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1R0</accession>
    <name>A0A0N4U1R0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FGF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4918</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1R0"/>
    <dbReference type="STRING" id="318479.A0A0N4U1R0"/>
    <dbReference type="WBParaSite" id="DME_0000055801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000055801-mRNA-1"/>
        <property type="gene ID" value="DME_0000055801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6158176at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000055801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="41007" checksum="D7F8B4F3CF82A3D6" modified="2015-12-09" version="1">MSGIATIGGSAASFQPFAALSLSLLPPLDYSTSTLLTNCARQAQQLRRHDEFRYDGPNREGALYCRSGTWLQILDKRTAEQEAIRDETIKPEYIKGTRKENSRFSVLEFISVAFGLVSIRGKESQRYLCMDRDGRLYAAVKQNYSTECVFMEEMLENYYNLYSSCSYGSRKKPWYVALRKTGRPRKGKNSRKRRKSSHFLVVHFDGARPTSEYNFMRDNLDSSIQLSNRKLMRNQRYDYNHKSYTNYDKPPPPNSLNDILSGTLLNHLSKGSVFKETRSLEINRHSNFLRKTSAKEDRRTVVEQHKINRKKRRRKTRLEREERKRQLRKHELELQRALAYEEQMRQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U242</accession>
    <name>A0A0N4U242_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTH1</name>
        <name evidence="14" type="ORF">DME_LOCUS5077</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U242"/>
    <dbReference type="STRING" id="318479.A0A0N4U242"/>
    <dbReference type="WBParaSite" id="DME_0000071701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000071701-mRNA-1"/>
        <property type="gene ID" value="DME_0000071701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="78"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN55104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000071701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28552" checksum="7428B444F8CD9466" modified="2015-12-09" version="1">MKRRNFETIVAENDSEPREKKADITQSNNLDWRECLEKIAQMRLEGDAPVDTKGCHMLADKTADPQVFRFQILLALMLSSQTKDEITAAAMHRLKDYGCTVENIRKLSGLELQKLLIPVGFYRRKAEYIKKVAEILVEKYGGDIPNTVDGLCSLPGVGPKMAYLAMQCAWDIDAGIGVDTHVHRISNRLGLVRTKTPENTRTDLEDLIPHSEWRRVNKLFVGFGQQICLPVLPKCSECLLKDKCPTIGVKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3T9</accession>
    <name>A0A0N4U3T9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5762</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3T9"/>
    <dbReference type="WBParaSite" id="DME_0000140201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140201-mRNA-1"/>
        <property type="gene ID" value="DME_0000140201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9132" checksum="3D4B6F7B4EDDD8B1" modified="2015-12-09" version="1">MFSSIPKAYIITKSSCSSAKQKRRSPLAHWSPMLYLPITEFTVTAPTPAFQSPSIDVTYQVSVEMLLIVEAPCELILIAVICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U423</accession>
    <name>A0A0N4U423_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5868</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex composed of 4 GMPPA subunits and 8 tag-335/GMPPB subunits; the complex is organized into three layers, a central layer made up of 2 GMPPA dimers sandwiched between two layers each made up of 2 tag-335/GMPPB dimers. Catalytic activity of tag-335/GMPPB is reduced when part of the complex and binding of GDP-alpha-D-Mannose by GMPPA induces allosteric feedback inhibition of tag-335/GMPPB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U423"/>
    <dbReference type="STRING" id="318479.A0A0N4U423"/>
    <dbReference type="WBParaSite" id="DME_0000150801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000150801-mRNA-1"/>
        <property type="gene ID" value="DME_0000150801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000150801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45520" checksum="936AA8ADEEFA7D0D" modified="2015-12-09" version="1">MNGLLHHRSSPERIKKLICLAMKAKSLPESSKPISSSAAIYDIYESIKSANMKALILVGGYGTRLRPLTLTQPKPLVEFANKPMMLHQMEALVAAGVDTVILAVSYRAEQLEKEMSKYAQDLGVTLHISLEDEPLGTAGPLALVKHLLRGDEPFFVLNSDIICEFPFEKMIEFHKKHGREGTIAVTKVEEPSKYGVCIFDEKDGKIDCFVEKPQEYVGNKISAGLYILSPSVLNRIELRPTSIENEIFPTMAKSGELYAFILPGFWMDVGQPKDFLTGMQFYLKYLHDRSPSQLASGHNIQGNVLIDQTAMINSGCVIGPNVVIGPRVRVENGVRLRHCTVLADSVIHAHSWINGCIIGRKCTIGCWVRIENTTVIGEDVIVRDELYLNGARVLPHKVISTNVPEPDIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U453</accession>
    <name>A0A0N4U453_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAM184 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5907</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U453"/>
    <dbReference type="STRING" id="318479.A0A0N4U453"/>
    <dbReference type="WBParaSite" id="DME_0000154701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000154701-mRNA-1"/>
        <property type="gene ID" value="DME_0000154701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="495"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000154701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="69620" checksum="A09ABC9DDFF123E5" modified="2015-12-09" version="1">MINNDDNIFLSFIYIKLGYLSDEFEERPSGVHLRSVSPHKSGSRSPRHSSKSPRPHQNIESPTPTPTFRDSRPEIIAWPTPPNSQNIYNNNTTCKKSNQENISSDEPSKLINMLKAASTGAPRGRESELKKKIQTLEDTVAEYERQKYNVMGTFSEYRERVAERERKLEAEYSNKIIALSEEVLGAKKDFEARMKSFQALQEKFEREKEQALEKLRQEHQKEIQLLEQRFSESQLLNLEQKYMIEIQRLEEERKSLKSEKERLGETFEMKLRRAQSLYETELSAAKMLYSKELEALRDHEEALKEELLARQDEFYDRLQELQHQSKISREELATCKNEVTALEKRLQAKEAEAMAISKELEEARNETNDSLRKLSKIESEVQQTKQQYRQQEEELQRKSSLLNIVETAKTKLEAVIRDLQTEVKALKNKVEFLEKERENLQSQSESQTQLQNSQVLALEAVLESVTKEKESTKQHYEGLLDKERQQAEEREFAMKKEFTSKLNELEDQYNSLRDHFEQSNLMDEQDYQKEEFSSLIENIESLRNELKIKDTKLTEMKTEIDKMKEQIQRENELNDDQLSMIRKEIWYLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U478</accession>
    <name>A0A0N4U478_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1508 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5934</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U478"/>
    <dbReference type="WBParaSite" id="DME_0000157401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000157401-mRNA-1"/>
        <property type="gene ID" value="DME_0000157401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000157401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7497" checksum="7ED657791DC9595C" modified="2015-12-09" version="1">MDVACLSEVRLPHVSSRVIIKPGSQQRYWLYHSSVSNNSGRNGVAIVTSEKARSALIEWKPVNDRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U569</accession>
    <name>A0A0N4U569_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6337</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U569"/>
    <dbReference type="WBParaSite" id="DME_0000197701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000197701-mRNA-1"/>
        <property type="gene ID" value="DME_0000197701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857971at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000197701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7982" checksum="3A563952E315ABC6" modified="2015-12-09" version="1">MLYVKEIPCFAIDPSQFKRIHVFSNASSTAYAALIYVIQDKKALISVKSRIVPIKDMTIPRLELFSHART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U584</accession>
    <name>A0A0N4U584_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6354</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U584"/>
    <dbReference type="STRING" id="318479.A0A0N4U584"/>
    <dbReference type="WBParaSite" id="DME_0000199401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000199401-mRNA-1"/>
        <property type="gene ID" value="DME_0000199401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="756206at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000199401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46881" checksum="67AA68EDC1E3EE0C" modified="2015-12-09" version="1">MSRNARRTTSKSESIGDGDMEFVDISICSVTGQTWTEQISRFESVASLKEKIWNRCGILPYHQGLVFGGELLTHANGQEFLYDLGIRQNSVVRLAIVPRSGPLALSPRTAITFSSHAILTSSRNNGSVNDSKSEVKCLNERYWDRKQRIFYDLCDFGQQISSDSPDFELANNQQINKRHIVSAPEDTSAKESSAGETECEEHANYSYEADDSSPKVFKYESSVTNRNEGMSARDRLLLLMNSRALSPSTDVNTHSEDGSELSSGVVICELNNAFKRLRVRRKHHAVGTASTMMQKNRTRNCCLNVYIYFNLKSIINYNLKFQGSDVTSSDDDRPCLKKHHECNMACSSSSRRNFAVARAQKYIGYQSQYRCYACAVKLSTISSASQCRCGKILCIRHRPAEMHMCTRIRKLQNVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5F0</accession>
    <name>A0A0N4U5F0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6429</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5F0"/>
    <dbReference type="STRING" id="318479.A0A0N4U5F0"/>
    <dbReference type="WBParaSite" id="DME_0000206901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000206901-mRNA-1"/>
        <property type="gene ID" value="DME_0000206901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000206901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50886" checksum="E203D2A3036A74DF" modified="2015-12-09" version="1">MREIIQIQVGQCGNQIGTKFWEVISDEHGIEPDGSYKGDTDLQLERIEVYYNEAQGSKYVPRAVLVDLEPGTMESVRYSTYGKIFRPDNFVYGQSGAGNNWAKGHYTEGAELVDEVLDVIRKEAEGSDCLQGFQLTHSLGGGTGSGMGTLLIAKIREEYPDRIMASFSIVPSPKVSDVIIEPYNATLSVHQLVENTDETFCIDNEALYDICLRTLKLTGPTYGDLNHLVSMTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGAAAYRSVNINELIQQLFHSKNMMAACDPRHGRYLTVAVMFRGRLSTHELETQILNVQNKNSSYFVEWIPNNVKTAVCDIPPRGTKMSATFLGNTTAIQEIFIRIAEQFEAMFRRRAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATVDDESDDNANVVYEQQNVQAQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U682</accession>
    <name>A0A0N4U682_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6772</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U682"/>
    <dbReference type="STRING" id="318479.A0A0N4U682"/>
    <dbReference type="WBParaSite" id="DME_0000241201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000241201-mRNA-1"/>
        <property type="gene ID" value="DME_0000241201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF51">
        <property type="entry name" value="GLUTAMINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="9">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000241201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="63362" checksum="D4F76AAEBE21ED98" modified="2016-06-08" version="2">MSDTAVKSPINNHQSITKLDSIPGRIVKENLMRNISCDSYTTFRASQHVADVIFDLFRDTETDKLAVATLLKLLAQCGIRQDDLRLEDFLKAVEKVSEERRQSETGSKLSLSSPTNIVYNAELERDVFKKCVGEKAGLIAKALKMQLIIPDWPTFTSAIGQIFESCHQFIDGKVATYIPQLARSNPTHWALSICTVDGQRHSWGDAKIPFCLQSVSKPFTYAIALEELGAEYVHTYVGQEPSGRLFNEICLDHNLASLLQQSRSLADRFDFALQQFKKFAASGYVGFNNSVFLSERATADRNYALTYYMREHNCFPPKSSTVQETLDFYFQLCSIETNADALAVMAATLANGGVSPLTGERVVCNLAVRDTLSLMYSCGMYDYSGQFAFTVGLPAKSGVSGDMIIVIPNVMGISLYSPPLDALGNTVRGVKFAEQLVEKFNFHNYDSLVYSETHKMDPRRRLGEARYESISNMMYAIRAGDVPALQRYILLGVNIMERDYDDRTVLHVAASEGNENILKFLLKKWNEVTEPQDRYGRTPTDDAVHFGHKKCEELLNKFFKYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6D4</accession>
    <name>A0A0N4U6D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6836</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6D4"/>
    <dbReference type="STRING" id="318479.A0A0N4U6D4"/>
    <dbReference type="WBParaSite" id="DME_0000247601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000247601-mRNA-1"/>
        <property type="gene ID" value="DME_0000247601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000247601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25434" checksum="9EC87ABE9516E883" modified="2015-12-09" version="1">MLCDVVFIVIADCYGCRDRHRNCRRRSERNSGSINNNNNEGPMECDDAATESSEQIASSGHAKNSTILNNHAAQLVNQVISRTQCTECGKHFRKGSSLQVHMTLNHGFPPPGSSLSSDDQGEKGSDCGAPMIDQTNGNTESTTPPIHQEIREIKNKIDEMRSAQSATRVEQVLSGLDTRVGRLEKQLEMALNSIYTIVQLQTGINSSVTRFKDEISEQLKAIRTILNESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U736</accession>
    <name>A0A0N4U736_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ixostatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U736"/>
    <dbReference type="WBParaSite" id="DME_0000278101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000278101-mRNA-1"/>
        <property type="gene ID" value="DME_0000278101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829051at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000278101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10103" checksum="736D6D0B455DBD4F" modified="2015-12-09" version="1">MYPNVKPPNDACNISDYVQAELTILKQGPAFKFVEPLLCQIVGTKFPSVNCERNGDKCECCCSIYHPGPNGFCVPLKQLHYDFACPVSFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7W9</accession>
    <name>A0A0N4U7W9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7264</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7W9"/>
    <dbReference type="STRING" id="318479.A0A0N4U7W9"/>
    <dbReference type="WBParaSite" id="DME_0000310501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000310501-mRNA-1"/>
        <property type="gene ID" value="DME_0000310501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF111">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000310501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22594" checksum="45D3A55D9FDE5B24" modified="2015-12-09" version="1">MSDSNVFCEEQSSKAENISMENQKYSKIIKKKKNTINIDDIRRQRNAANERERRRMNSINKGFDKLRLRLPKNHNDRRLSKVDTLKQAIKYIRQLTELLQQEGVSPAYITTKLQNVQAPMLLIKSFEGIECLICHSCGVEDGPCTGATCIAPVNGYCGFQEILNAEGYAISRQQICLKTNMVRSGEIYVSQLKKCIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Z4</accession>
    <name>A0A0N4U7Z4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Immunoglobulin-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7294</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Z4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Z4"/>
    <dbReference type="WBParaSite" id="DME_0000313501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000313501-mRNA-1"/>
        <property type="gene ID" value="DME_0000313501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000313501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37891" checksum="DE3B24D65B2CDE55" modified="2015-12-09" version="1">MSERNVKSDSEFGSDFNLEKEFRFCDGIVSKLEQESGGAPTFSEELSQCIERLEVLIHEVTARALFSENETIDDIPANYIKYLLLPSFMATLTQNINNPTETRVDILNKAKRYFRSFLEMLHFYKVIDFTLPWIDEDVDMEERQVKSNDIFELRNKKRRMYEQQRQLEQSLKILQTQYDRGEEDDSLLRKLYLTRVRLSALKALSELQMIEQELPLAERMLKIRSGELKADPLVKPPQSRPPFIITRDQIQKKVFGLGYPSVPKMTVNEWYDEMANTGGFANSSSASVVPENKSDDSDDEQVQEEKREKAIKWDEYKDCTFFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U815</accession>
    <name>A0A0N4U815_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7319</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U815"/>
    <dbReference type="WBParaSite" id="DME_0000316001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000316001-mRNA-1"/>
        <property type="gene ID" value="DME_0000316001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10530577at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000316001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10580" checksum="2E011326C1E79019" modified="2015-12-09" version="1">MLMARYNMVQQNGGPQSSIPSTSQRIARPLRRPQIPQKPVLPNYGPRPIGQICKNDVIGLSKWAISSPVDAVEILGKGQEIAKPVLSRSTCSLNRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U820</accession>
    <name>A0A0N4U820_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U4/U6 small nuclear ribonucleoprotein Prp31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-processing factor 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS7324</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U820"/>
    <dbReference type="STRING" id="318479.A0A0N4U820"/>
    <dbReference type="WBParaSite" id="DME_0000316501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000316501-mRNA-1"/>
        <property type="gene ID" value="DME_0000316501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="13">
        <location>
            <begin position="213"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN57351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000316501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="54339" checksum="EF26F71F95581334" modified="2015-12-09" version="1">MSLADELLADLDEDEGIIEANEQENLEGQLEEVGEQFPNMNIYDRVDAVAKLASTQNYKDLIAKMEEQLNLEEIPPVSKPLEADPQYKLIVQLSSLAADIDQELNVIHKFVRDKYEKRFPELESLVPNALEYLATVKLLGNDISTKGQNKQILSEILAPATCIVVSVTASTTQGKALDANELKAVQEACDLAEKLHTDRLNMYRLVESRMTLIAPNLCEILGAGTAAMIVAKAGGLAPLARLPACNLYVLGAQKKTLSGFSTTAILPHAGILFFHPIVQGVPPDFRQKTARLLATKTTLAARIDSLHEYIDGSAGKNLFEQIKQKIEKMLEPPPVKIAKPLPKPLDKSSKKRGGRRVRKMKERLGKSELRKKANRMNFGELAEDVIQNNVGFSLGQAISGGISGGRIRTAVVDPKTRAKMSQKLQKSMERQRAMGGVTSVRSRNTAGTTSSVTFTPVQGLEIVNPTLKQERTGSSSTTYFSPSATFVKVQTPVVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U846</accession>
    <name>A0A0N4U846_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ig-like and fibronectin type-III domain-containing protein C25G4.10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7351</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U846"/>
    <dbReference type="WBParaSite" id="DME_0000319201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000319201-mRNA-1"/>
        <property type="gene ID" value="DME_0000319201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040969" evidence="2">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="234"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000319201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61054" checksum="8B0D42B941A7E376" modified="2015-12-09" version="1">MYSFLLIFAIILHFVLHIIYASTVSMCCHRRGVSEACSNLLCDPTKPPNDFDVYNIFDHKINCLPHMKNIAECLADGRNHIYCCINDAKDRDENACFGLCAGEGLNNLERWDNYQTCLALNIATMYKCFERGYLNIPSPPTATRIISKDMTSAVFTWSPPESNPHLAYSYHVVCRESDNGVTEMTIDTRSTKVTLTGLRADSKYSVAVAAVSRDGIQRSLLSDILYFYTAGVAPRISAYKQHVSISRKSEFVTLACRMQIPGTMHTSAHIQWMKRNDKNGQYYILSGNRYSLTNYISSHGQPRLYVSTLHIQPLQISDFGTYRCIASNDFGTSSSNIQLSIRKVTFASPIPPELPYQCCQRQNIRSPCASICGTQAGKRGVLRAETFMNNQCDDEIGKFLSCTIAGIDEGECCLRNKVPNACLPLCDETLEAGNEIPFTCALHTFSIFECRMQNAEKRPKPVTGLKANSFGDTTLVSWNRVDTADIYYIYWKRKSAISWEMRSISNTDKRINGAEEIVVLASNDFGNSPASQLDFDGNRWVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U874</accession>
    <name>A0A0N4U874_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ADP-ribosylation factor-like protein 8B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7384</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U874"/>
    <dbReference type="STRING" id="318479.A0A0N4U874"/>
    <dbReference type="WBParaSite" id="DME_0000322501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000322501-mRNA-1"/>
        <property type="gene ID" value="DME_0000322501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000322501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21462" checksum="6C98D090FD198DDA" modified="2015-12-09" version="1">MLAMINRVLDWIRSLFWREEMELTLVGLQNSGKTTFVNVIASGQFTEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVNAIIFMVDAADEDKMEASRNELLQLLDKPQLDSIPVLVLANKKDLPGALDERQLIERMNLSSIQNREICCYSISCKEKDNIGTFRIFYCICKYSGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U892</accession>
    <name>A0A0N4U892_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7409</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U892"/>
    <dbReference type="STRING" id="318479.A0A0N4U892"/>
    <dbReference type="WBParaSite" id="DME_0000325001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000325001-mRNA-1"/>
        <property type="gene ID" value="DME_0000325001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895">
        <property type="entry name" value="PROTEIN CBG03177-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895:SF17">
        <property type="entry name" value="TIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232700" evidence="1">
        <location>
            <begin position="26"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000325001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41515" checksum="8FFFD4BCF3DEC9EC" modified="2015-12-09" version="1">MQLAISTRQIILFFAFQLILNFIRASSDVKVRGKRQCGCDQFQPNVPGQCNCNPGIYPQSMSCSCPQIEECGCTNQCPTICQQTCMQQCLSYMPYAACQQACQQACFAPCGPINPQPQPPYYPVPVPQWCLSRCMQQCQMTCGQMYNDQCYPGCNQDCQQICPSPPNPIPVIQRCTPQCMQLCTQSCLPYLPENMCQARCYSLCFDNCQFPPYPPPGPYPPPGPYPPPGPYPPPGPYPPYPPCIPDCNPQCSPCNEPSGPCPLPCQQNCQINCHGNQFGPLSPFSKRPSQQAIAVTLQASTILSPQCKDLCQGSCNQQCLPALPSAQCQSACQALCQQNCPKSVPKVPCQTTQQMQCYCPTGYQPCDNGTVCCMVSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8B8</accession>
    <name>A0A0N4U8B8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyanoexosortase B system-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7438</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8B8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8B8"/>
    <dbReference type="WBParaSite" id="DME_0000327901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000327901-mRNA-1"/>
        <property type="gene ID" value="DME_0000327901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845413at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF5">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041120424" evidence="1">
        <location>
            <begin position="30"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin" evidence="2">
        <location>
            <begin position="136"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000327901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36570" checksum="58E00FE1D9CE18A8" modified="2015-12-09" version="1">MIIDSSLITMVLPLISVVLLINDVNFVESQSILEFFGLNTESKPSKRMPLDDITSQSIGLINYIRAIQKNPSNDNLWKKLNGALPTLPEITLLDGVPAIPGLTGSLTGAGGCLPKYMPLVNHESPNFFQNFLRFIPGAQDYLLSLIQKPDINANALIGKYQWVVSTVGVHDRYCPTTEFKNLLQNRNTSTFTTVDSFYENGPRGPAKVGFGYGLIHHRKVNIYFQENPCPYQIVMVGPIDNHSKQYEYVVISNWAKYPVIGLARNLEVFNSKYRKELVERFKNEGLIHDFSDLIGNSINFVDWSQCKVLSPIGFVMNIMDRLFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8C5</accession>
    <name>A0A0N4U8C5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7448</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8C5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8C5"/>
    <dbReference type="WBParaSite" id="DME_0000328901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000328901-mRNA-1"/>
        <property type="gene ID" value="DME_0000328901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="188"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000328901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46821" checksum="D80C5A3B008AAC3C" modified="2015-12-09" version="1">MASSSNSDSVKQQSIDDNEKENPNLDIAQLKFLVSLSELNADVRAKKLDELLQLIKENEMGPYYKLVCDEIRINIDDTLFNELTSKNEKRLQEIDAEIADAEQNLGESEVRQAYLRKSEYLCQIGDKEAATAAFQKTYEKTVGLGYRIDLIFNLIRLGLFFLDHQLINTNIAKAKDLMEQGGDWERKNRLRSYEGLYRMSIRDMKGAAALFLEAVPTFGSYELMSYENLIFYTVICAVYALDRPDLRSKVIRCNEIQEQLTGGNEKGALAAARRYLEAFYCCKYDELFVVLAQLENEYLKLDRYLTPHYSFYSRAMRLKAYEQFISPYKTVRLDMMAKDFGVSKAFIDKELHRLIAAGHLHCRIDAVRGVIEMNHPDTKNHLYRSVLKDGDILLNRIQKLARVINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8I3</accession>
    <name>A0A0N4U8I3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS223</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8I3"/>
    <dbReference type="STRING" id="318479.A0A0N4U8I3"/>
    <dbReference type="WBParaSite" id="DME_0000335701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000335701-mRNA-1"/>
        <property type="gene ID" value="DME_0000335701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836967at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000335701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22779" checksum="F65756E552CC8CA5" modified="2015-12-09" version="1">MVRTLFYSIIKLMNHIREGASTGTSTAICRLSTVKSVVQIRCRPCQEILSWYILLSIFSLISKSTKNKKIYGLFDKIIMKRKESVLGFNNLGFLKMSSWSISLKKYLHTRVAQLSVSTISAHALSPLSSQILFECRQCSFETTEKNNAIEHMQCHRNMIDCKKEDMDLCHLDSVAKIMASTKQQMVGPIIRVFGEESEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8J8</accession>
    <name>A0A0N4U8J8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A</fullName>
            <ecNumber evidence="8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS241</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8J8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8J8"/>
    <dbReference type="WBParaSite" id="DME_0000337501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000337501-mRNA-1"/>
        <property type="gene ID" value="DME_0000337501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000337501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33447" checksum="FBB5BC7EAA197A5E" modified="2015-12-09" version="1">MHKWRCRIKYFKKCDNCYNNIYFRYGSRISATAGYIYALRPSADLWTRTLLRQTQILYSPDCSLILTLLDVRPGAIICESGTGSGSLSHFLALALAPDGHLYTHDIDEVRIKKVESELRVHGLGAVTTCIHRDVTEDGFFVENACDGVFLDIPSPWLTVSHAKKAFNRSRGGNFVSFSPCIEQVQKLCDALKREAFIQIETMELLPRKLKVMNISETTLKEFSLMTAAEKKPKTMVNSGSGERKRKIDEDTAEAMQREEQLPQKRTLLPSPPSQPTHTGYLTCAKLLPFFDETSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8L2</accession>
    <name>A0A0N4U8L2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Calx-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS258</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8L2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8L2"/>
    <dbReference type="WBParaSite" id="DME_0000339201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000339201-mRNA-1"/>
        <property type="gene ID" value="DME_0000339201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF76">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="118"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN50285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="DME_0000339201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53933" checksum="D6BFC72FFD127A90" modified="2015-12-09" version="1">MKAKTLDEAIIERSIEFSARVYSIQEADQYVKLRILRHGPTDTSVTFRYTTKNGAAKKDLHFLQKSETERFSPGESIKEIYIGLIAEASWRAEHVFYVQLRIESNENSENKTVLGKISVASVRKPDLSSSFIGEPMVQFVQRNYVRYVRAFVTRIGRHDKKNFLVHYYTEGITAISDIDFQAVTDGTLNFADSEYEKFIDIRIFDDMQEEKDETFVIQLSNPSQDITIGPNNKAVVTIMCDDNILKNIKDISKLTTYYLDNMIHGANNWYEQIVEATSVNSGDTVNATFLDCILHVIAFPWKIIVALIPPPMICGGWLCFFIALSDFANIFGCMVGLKDTATAITLVALGTSLPDTIASKIAAENDRTADNAIGNITGSNSVNVFLGLGLPWLIASIYWSTKNENFVVNAGDLGFSVALFTITSVLYHLMLTLRRNIAFFGNAELGGPICPKLFSAFFIFSLWLAYIFLSILKTYGRVIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8S4</accession>
    <name>A0A0N4U8S4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS327</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8S4"/>
    <dbReference type="STRING" id="318479.A0A0N4U8S4"/>
    <dbReference type="WBParaSite" id="DME_0000346101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000346101-mRNA-1"/>
        <property type="gene ID" value="DME_0000346101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000346101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28704" checksum="45D415D7484E1595" modified="2015-12-09" version="1">MERTGLVKPVDNNLAFSGTICEKTTNQSDYIPKYVKKTIPFKESEKVVKSSAPLNDKSTHQYDFTKKKIEKIKQFKPSYSHSISTDPFNAISLSHQDYVNHEINKTVPIRPSDEQGLPREAFEILLLILFYGTTEHRANFYKKLIQLNRHSRHNEVYQRSINGNELMEKKTTYLHDYVPVKCHHQSPFRPKESQYASHNAFMDLTTHACDYINRTIQICPAQYVLTRGRKSFKLVGDSGGHRFYQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9G3</accession>
    <name>A0A0N4U9G3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7731</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9G3"/>
    <dbReference type="STRING" id="318479.A0A0N4U9G3"/>
    <dbReference type="WBParaSite" id="DME_0000372601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000372601-mRNA-1"/>
        <property type="gene ID" value="DME_0000372601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051712at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028085">
        <property type="entry name" value="FNIP_mid_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14637">
        <property type="entry name" value="FNIP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein middle" evidence="1">
        <location>
            <begin position="46"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Folliculin-interacting protein C-terminal" evidence="2">
        <location>
            <begin position="361"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000372601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51696" checksum="7535B677A43E8626" modified="2015-12-09" version="1">MNKFIKNELFNSAHLSEKKGKKVKEHFSDNSGHWSSRSRLSSTSSIYDENTKRIAVGLILNEDLRHFVFQHISLIEAEIFKLQTQIAKGWIEMAHNICLLHNSPRLQSPVWLSLIRQEENYEIIARTFCSNLASVLKNFDLKTTHFFFSKLLSCVLMNHLSWVASVAQRDCHKNETQHSLLFGTNSEQSYGLYNIHLAQHLEVCGNISGLIRSARTVVIGSETKIISQLLYLLTYFIRCSEIHRNEKGGIFQHSFSLCAYNFRKDKLNILLFLIEVDNQLISTIFEEKFKNVDSDWHFSLSNIIMASKSFDLAHSLLAGPCDSYCSHFVLSGLCRSNIDYEVCLVLYITIVGDEITLNESQMASPCDIIVTMLEQFIGFYDMGASPNILLAIIENTLSEILRKSLSDNDKKINFTNSLSSEHIAEIIGCDYSDLRLIVNVAAVYYPPVLHLVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9J3</accession>
    <name>A0A0N4U9J3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7768</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9J3"/>
    <dbReference type="STRING" id="318479.A0A0N4U9J3"/>
    <dbReference type="WBParaSite" id="DME_0000376301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000376301-mRNA-1"/>
        <property type="gene ID" value="DME_0000376301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000376301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18413" checksum="F7421555FC10BD34" modified="2015-12-09" version="1">MNEFENSFLPVPNDRRVMYVCGNPWFCNSALEWFRAYLRENVDIDIDKPGCIAVCMGPINSCPPPGTPLRNNDFCPINEQVLPLTGNALSLVGWIILAIIMTILLISICLLALVRYGISYRRKKQKDQEMEDEQRIISTSGTFFECKIFCAEYLKVNRNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9L4</accession>
    <name>A0A0N4U9L4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7791</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9L4"/>
    <dbReference type="STRING" id="318479.A0A0N4U9L4"/>
    <dbReference type="WBParaSite" id="DME_0000378601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378601-mRNA-1"/>
        <property type="gene ID" value="DME_0000378601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="99"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="330"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="70796" checksum="53D8CA307C23FDED" modified="2015-12-09" version="1">MVLSLFSSNKILARYRISKSIDYDGWREFSVLYGKVSSRKHKKWEGDGYLLCKLSTAVLLNEVKLVEVEDNSGTPIILHDFLSKSLRPHQKDGIFFLYEKLKLVNSGAILADEMGLGKTVQTISLIWAFLRGRGRNSLIHNCLLIVPSSLLANWQFEFIKWLPNVEELNGYWSYARYNPVALMSYEMVSRSFALLSRRSFGLVVCDEAHRLKNLNGRLRQQIASIKADRILLLTGTPVQNDLSEFYSLLDLVRPGYFGTVADFAKRCFFFSILDCFYSDDYIFWCRPSKLQKEIYSQIVELLHSEHLVLIDCLKKLCNHPCILHLSIQHHLTSNVSFLKYYNFLKFKNSLIYFGLCKSLRISSLRIDGATQHQKRMNIVDEFNKENSSSAVLLLSAKAGGVGFNLIGANRLILFDFDWNPSVDLQAMARIWRQGQSKPCYIYRLLTAGTIDEKILQRQIKKSGLSSFIESSAVTDDVVSFSSDDLKDIFMFDPLSNCNTHDLIECKCDGRGKPYFDTNEEKELEEEIENINGTSIAVHELENVCIISNVSTFILIITFRKRKFTTIFNISMGTLLRWNHYSPLQVAEYEEMKNQMGLQRYPLHDVTFVMRLTSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAB6</accession>
    <name>A0A0N4UAB6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str_synth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS445</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAB6"/>
    <dbReference type="STRING" id="318479.A0A0N4UAB6"/>
    <dbReference type="WBParaSite" id="DME_0000408101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000408101-mRNA-1"/>
        <property type="gene ID" value="DME_0000408101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF124">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE CONSERVED REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000408101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39588" checksum="E0043FD77C5412F8" modified="2015-12-09" version="1">MLPFDNESSIITNNNEVLKNAEIYLKDKIYGPESLAIHEGTQHIFSGLRNGLIIEMDINEQGEINIVREFRLHDIHQGSCDGTFKSFPKCGRPLGVRFRKLYRNKLFIADAYHGLYELDIITGKSKLILQAGTLITNNISDLPLRHLNDFDETFNGKIILSEPSMKFSDRDCILAMLEHSGDGRILSYDDRRNELKVIASGLQYPNGIQIEGDNCVFCYDEPNWKATIFIDNLPGYPDNVRLSAQGFVWIPLPEVRLEDDKWLTMNSFLRNMIAAFIPPSILMDLLKWIAPKYGLVLAVNRDNASIIRSLHDPDGRTISAITEVAEMNDGTLLFGSDTNNFIAKLDKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAS2</accession>
    <name>A0A0N4UAS2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTPase-activating protein RAB7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8150</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAS2"/>
    <dbReference type="STRING" id="318479.A0A0N4UAS2"/>
    <dbReference type="WBParaSite" id="DME_0000426701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000426701-mRNA-1"/>
        <property type="gene ID" value="DME_0000426701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF645">
        <property type="entry name" value="LD27216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="268"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000426701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="67593" checksum="89366FCCCB56752F" modified="2015-12-09" version="1">MVVIFVYDYVYAHGIMIEWMPIDDDGWVIASAEEDEEVSSFRSSESFESRREFNNRLKFSVDIKDLRSFQCVEPKKGNRDGYPWVRFISKDGSAFTALYFRQKGLSSFIDHLQKYATLKRSAREANLVLFTDERIAALEQSVSLLNLNSDFFSRMMAQPYATAMTGLGKVATFVQDQVIPSLLDSDAVSAEEQIRAMRELREQEEEAAGKLRLHDDCGFELVTQLELPQRPEFSREQAVDEDVWKRHKNSDGSFGDVHSLKVLIFRGGLVPSLRIEAWKYLLGALDWKKSNVENTELMKQKAQDYYRMKLQWKTINADQESRFADYAARKALIGHIFKKDVSRTDRTHSFFGGFNNDNVTILNDILMTYCMYNFDLGYVQGMSDFLSPLLVILQNEIDAFWCFVGLMNRVQRNFEMDQSAIKKQLMDLRDLLMVVNPKLANYLEAHKSDDMYFCFRWMLVCFKREFSFEDILRLWELSLIIKFMVLWTDLPCSNFHLLICVAILDNQMNYIIENQFGLTEILKHINDLSMNIDLNETLTSAEAIFHQLSASQDKLPRHICKILSLGDSNDDDSLYPNSMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBP2</accession>
    <name>A0A0N4UBP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab-2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8517</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBP2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBP2"/>
    <dbReference type="WBParaSite" id="DME_0000463401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000463401-mRNA-1"/>
        <property type="gene ID" value="DME_0000463401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000463401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28545" checksum="F21C0C4DCAEFE896" modified="2015-12-09" version="1">MCAVIRKAALRLMRESFIRVITMVNNTANNRFEDFGPLYNYQYRIIIIGDTTVGKSSLLRHFTEGRTAEKNEPTVGVDFYSRMVEIKPGFRIKLQLWDTAGQEKFRSITRSYYRNSVGIIIVYDISNRKTFEHITQWLNEAETNINDSNHCVIQLVGHKADLDADRQVMYEEGEYFAKYHKIKFIETSAISGENVQEAFVMLAREINNRIEDGSLQIIEGWEGIKSGVTMTLSLSEESSRIPSPSSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC73</accession>
    <name>A0A0N4UC73_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS8736</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">Golgi stack membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC73"/>
    <dbReference type="STRING" id="318479.A0A0N4UC73"/>
    <dbReference type="WBParaSite" id="DME_0000485301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000485301-mRNA-1"/>
        <property type="gene ID" value="DME_0000485301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN58763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000485301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22839" checksum="80599365819660DE" modified="2015-12-09" version="1">MGRWYQYELAGLLGYQEEGLTKKNGKLVFLGLDNAGKTTLLHMLKDDRMAQHVPTLHPTSEELSLGGIRFTTFDLGGHEQARRVWKDYFPAVDAIVFLVDCADVVRIDESKREKLSLKLESLLADEQVANCPVLILGNKIDKQNAIGEDQLKWHLGIMNLTTGKGQIARADLSTRPLEVFMCSVLRRQGYGEGFRWLSQYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDT7</accession>
    <name>A0A0N4UDT7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Robl_LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS618</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDT7"/>
    <dbReference type="STRING" id="318479.A0A0N4UDT7"/>
    <dbReference type="WBParaSite" id="DME_0000551201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000551201-mRNA-1"/>
        <property type="gene ID" value="DME_0000551201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000551201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10216" checksum="CDC7D8A030AC84B0" modified="2015-12-09" version="1">MGNEILSESSLNFSIKRLLGRAIRSTMDEETTTLHASLLHQLCDKSKSVIRELDSSNDLTFLRLRTRKHEIMIALDRDYLLAVIQNITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDY8</accession>
    <name>A0A0N4UDY8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9307</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDY8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDY8"/>
    <dbReference type="WBParaSite" id="DME_0000556601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556601-mRNA-1"/>
        <property type="gene ID" value="DME_0000556601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="14">
        <location>
            <begin position="478"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="13">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="686" mass="78198" checksum="13EB1D0AE3E2A13F" modified="2015-12-09" version="1">MTKRKGDALNLLCEEFSNDQDLKVPKYEPVEPVELNNALYFTKVVGHPRRFSRNALSLSELLKLIDPKASIHFNFMIDLPWLFAQYPSQSARNPLTLIIGEDGNERKLLRQQAVEIKAENIKIGCARLPIPFGTHHTKLSIFESNNEKIHLIISTANLLSNDWEDKTQAFYHCSGEIMTDNEEGKNDDAFRNELLEYLNFYNNSRDSKLIEPWRDLIKKADFSAIKARIIFSVPGSHKGSNKEKYGHLRLRNELRNLNLVNPTFHAQFSSIGSLGPKPESWLCGQFLTSLSGGKSCASSKLKLIYPCVEDVRCSIEGYLAGGSLPYRAVTATKQEYLINFMYKWRSEKFGRTHVMPHIKSYSAFNEDSSIPSWMLITSANLSKAAWGELQKNETQLTIRSYELGILLTDDASMALLPYDIPLTKYETNDKPWVYDLAYQKKDRNGISWPVVEPSTIFGIHFYNMADDVEEIVLSHGDISIYASDLETLFEGNWLTDRILSFAINYLYETMLNDDEKESVFIFHAPLCQMLKFMDFNSIMSLCESLSWNEKEHLIFVLNDHEDPSSPGGSHWSILFYRSGNEYFSLVDSLVKPQLDTAKQMLKIMTRCLGLACAELVVENSAKQQNGSDCGLYAIEYVRLYLSAISEKNKTVNYENLSADEVGLRRDGWLTIIRNLINEKKSAACSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE88</accession>
    <name>A0A0N4UE88_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS723</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE88"/>
    <dbReference type="WBParaSite" id="DME_0000567801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000567801-mRNA-1"/>
        <property type="gene ID" value="DME_0000567801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287170at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000567801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9074" checksum="6A9E844831584D09" modified="2015-12-09" version="1">INLKNLKPNILKNFNYSICSFTSNLLDFTFPHNSHIFQQIISGDGKAYVKQGSKSVHISKSGMVASDGITTALMDHYGRIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEI7</accession>
    <name>A0A0N4UEI7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS788</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEI7"/>
    <dbReference type="WBParaSite" id="DME_0000579401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000579401-mRNA-1"/>
        <property type="gene ID" value="DME_0000579401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039197" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000579401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8486" checksum="CA9F295A63DD27EB" modified="2015-12-09" version="1">MNRIGVPLITTWTLLTPHSRATVWLPVAYVWRISCHFIYEGLYTLAKPRHSNLIPRGSHASLRLHLICSYCIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEJ8</accession>
    <name>A0A0N4UEJ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L27a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Large ribosomal subunit protein uL15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS802</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEJ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UEJ8"/>
    <dbReference type="WBParaSite" id="DME_0000580801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000580801-mRNA-1"/>
        <property type="gene ID" value="DME_0000580801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="12">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000580801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28592" checksum="18B80E070081A6B2" modified="2015-12-09" version="1">MATSKKKTRKLRGHVSHGHGRVGKHRKHPGGRGNAGGQHHHRINFDKYHPGYFGKVGMRNYHVRKNQLYCPTVNVDKLWSLVSENLRKSYAGRTDKAPVIDVVRAGYHKVLGKGVLPKQPVIVKAKFFSHSAEQKIKKVGGACFQQHTLAMSTQQELACVYAALILQDDDVAITGEKISTLLKAANVNVEPFWPGLFAKALDGVDVKTLITNVSSGVSSGSVGAASAVEIASASPAAESAPAKVEKKEEPKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEQ5</accession>
    <name>A0A0N4UEQ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9399</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEQ5"/>
    <dbReference type="WBParaSite" id="DME_0000587501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000587501-mRNA-1"/>
        <property type="gene ID" value="DME_0000587501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851039at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000587501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17915" checksum="DD46CF79764F6CFA" modified="2016-06-08" version="3">MFNQPIRASFISNQRYLYEFSSTTVFRKWKIIPLIIPLIIIQMNLLQFIFLPLVQGCVPTGIGGEHCCLPLVATPSNTSLSDGIMSFEYNSLTCRTTVTASCSKPATTLEQVQAAIKVNQVSLLSVGIDTATTNGFCDVNRRWTMGTTPIMVESIQCVLSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEV9</accession>
    <name>A0A0N4UEV9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS874</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEV9"/>
    <dbReference type="WBParaSite" id="DME_0000593501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000593501-mRNA-1"/>
        <property type="gene ID" value="DME_0000593501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000593501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17585" checksum="0E192B0D97EAF65C" modified="2015-12-09" version="1">MATSDFLCKSLNSPETMNIISHHETNSSDFSEHILQTPITSSTLIGEQKFDRSDKSKISSKSYFPIETKFSSSLSSATTSILSSEYHQTDNSDLLNLSLTSGSLTNNAINPSSTTTETATTTITNKSPSALPVLLTISSHENYSKELGKTSSSVKRRRKPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF24</accession>
    <name>A0A0N4UF24_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS953</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF24"/>
    <dbReference type="STRING" id="318479.A0A0N4UF24"/>
    <dbReference type="WBParaSite" id="DME_0000601401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000601401-mRNA-1"/>
        <property type="gene ID" value="DME_0000601401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192915at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042415">
        <property type="entry name" value="CNPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341">
        <property type="entry name" value="MIR-INTERACTING SAPOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3456" evidence="2">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000601401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17315" checksum="04AF3DC1A12D3F99" modified="2015-12-09" version="1">MEAEYTNSLISVIVAELLRGLCWHLLLYYLIPYARSEAHIHELLEYICDKSKEYSIVTHPITGKSVYVRKDSTSRVGSVDKTVLSKLNAACSDFLDDHEEELVNFMKIVQNEPVREFCHRRLNICTSVDVTPFPDLINESARHFDESHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF62</accession>
    <name>A0A0N4UF62_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS997</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF62"/>
    <dbReference type="STRING" id="318479.A0A0N4UF62"/>
    <dbReference type="WBParaSite" id="DME_0000605801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000605801-mRNA-1"/>
        <property type="gene ID" value="DME_0000605801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10040561at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000605801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8452" checksum="5338C10BC9D5A594" modified="2015-12-09" version="1">MCDSSDCNNQGTCIGNKQTYFCVCRLGYTGTKCETTLCDSDRDCNQKGICSGTSADFKCLCNIGFTGDKCEIPLHVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF96</accession>
    <name>A0A0N4UF96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1034</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF96"/>
    <dbReference type="STRING" id="318479.A0A0N4UF96"/>
    <dbReference type="WBParaSite" id="DME_0000609501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000609501-mRNA-1"/>
        <property type="gene ID" value="DME_0000609501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000609501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24611" checksum="DA5B11C2CAF1FAD3" modified="2015-12-09" version="1">MFVLAVMEDNIRVKPHQFGELFEQVVRKQLNQRFANKIVPGLGLCIAVHDFIEVGASFILPSDGSSHTRVKFRFIVFKPFVDEIIEAVVASSNSKGLTLSLTFFDDIFVPAERLPQTSVFEENEQIWYWEYRSDEDEPPAKLYMDPGKRIRFRVVENIFKDIDPGLAPEEAMKEKSYQIIGSMAESGLGCVQWWAPAEEAFYEKDDDEEDQETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFC3</accession>
    <name>A0A0N4UFC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1064</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFC3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFC3"/>
    <dbReference type="WBParaSite" id="DME_0000612501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000612501-mRNA-1"/>
        <property type="gene ID" value="DME_0000612501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000443">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000612501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56331" checksum="EFF0D11D7DF44503" modified="2015-12-09" version="1">MSDEQNSVSANNSKVQFGSLANEETVQKLLAENEAENEKNDEFFDLDSVDNPMEREVMAEFERRRRARTLTLPTDDGHVKLLLRKLNEPICLFGEDKLDRKERLRTILSTMSEEEVTRILHSPEETETMQQRDSATWYHKGPASLRDARIAIADYSLPRAKERLKKARENAVRSQHQIAVATQEMYRWISSLSVYCSQVADIRPVSSCEFSPDSMHLITSGWSGECCIWSIPDCIRERHYIAHNRQAGCARFHPGAYISQEPYALNAATCGYDGSVKLWSVETDNPLSELEPHSQRVSKIAFHPSGRFLATCCFDCSWRLFDVDYETEVLFQEGHSKPVFHADFQIDGSLILTVGMDCYGRVWDLRTGRCIMFLEGHQKEIYCGQWMPNGYQMVTGSADNSCMVWDLRIRRAIKPIAAHTSLVSGLRIEGNGQYMITSSYDNSLKVWETNGWKPLKKLMGHDTKVMGVDISSDGKWIASVSFDRTFKLWTKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFT0</accession>
    <name>A0A0N4UFT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1208</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFT0"/>
    <dbReference type="WBParaSite" id="DME_0000631101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000631101-mRNA-1"/>
        <property type="gene ID" value="DME_0000631101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5806405at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000631101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="21203" checksum="B71BE1F2CF7F2943" modified="2015-12-09" version="1">MHCLRGGKAVLLSSNDSLTKILPHLTKSQLSEHERGNFFQIRECLRLENHWKNENKESCLTKIHSIKKAIRGLHLRRTELQKDCVAKHDFVENIKDPNQKPSFKERKCIKLDKLFINNNIWKKKQKRRRTLRKRDLKREICHQETKIWHKFCTKLSKCCSAFNKLVSRQTAMLRCSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFX9</accession>
    <name>A0A0N4UFX9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9482</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFX9"/>
    <dbReference type="WBParaSite" id="DME_0000637101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000637101-mRNA-1"/>
        <property type="gene ID" value="DME_0000637101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="14">
        <location>
            <begin position="290"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000637101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64268" checksum="44B20D7B553CDA10" modified="2016-06-08" version="2">MSFRLYGSARILQLDENGECISFNNDSIVDLGISSDNHCIHIFGRAIRDSKLLISTTQFFRLNSRIIFLHSPSSKISNELSIILLVDTNLNDFITALRLCQSLKPREKPSPAKESEESKSVFDARTESASAMQYFQFYGYLAQQQNMMQDYVRTSTYQRAIHANSIDFNDKIVLDVGAGSGILSFFAVQAGARRVYAVEASSVAVNCAELVRANNLSDKIIVVAGRVEEITLPEQIDIIISEPMGYMLVNERMLESYIHARKFLKPGGRMFPTVGHLYIGLFSDEALFIEQYSKGNFWCQENFHGVNLTGIRTQALLEIFKQPIVDTWHVNTLMSGTIKWTINFEKDPESKLHNITIPFQLTANRTGFIHGIATWFDVAFVGSSETIWLSTSPTEPLTHWYQVRCLFDRPLMVFIGQTVNGCLSMVANERQSYDIVLTAEVGTMLAHNTLDLKNPFFRYTAAAVIPPAGFNNEAPSDNLLQQNGIIIFSLDILGGRFIISGVGNAGAINHMEYSLDGATSMSNGCSESMPNSGSTSVPQFLSAQNSLVPNDGSTNIIDILSNSHSQLTQEQQLVETGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGG6</accession>
    <name>A0A0N4UGG6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1315</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGG6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGG6"/>
    <dbReference type="WBParaSite" id="DME_0000658601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000658601-mRNA-1"/>
        <property type="gene ID" value="DME_0000658601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000658601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18692" checksum="29FB7864D7F09EF0" modified="2015-12-09" version="1">MLYRILNFLIAAIGFLLSLYGLYVEFKLDHLGEVYQPMCDIATYISCSKAFRSSFGTGLGIVEPLLGANHLLNQKNPVFGIITYIIFMFFQFFDNRCSAFLSLITSVLMNILSVYLFFVLVYLRTICVVCFAIYFVNAVLLIISIKRYKSSKNIIKNKNKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGP0</accession>
    <name>A0A0N4UGP0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9695</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGP0"/>
    <dbReference type="STRING" id="318479.A0A0N4UGP0"/>
    <dbReference type="WBParaSite" id="DME_0000666901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000666901-mRNA-1"/>
        <property type="gene ID" value="DME_0000666901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="6">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000666901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9081" checksum="3A1E230ACD34C264" modified="2015-12-09" version="1">RTELKSIKNKCKKGSGDGRVKFQIKNDHLKKEFLRAGAISSALRKALGLGPNDIPEWIYRMRRMGFIKGYPPGYLRKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGS9</accession>
    <name>A0A0N4UGS9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9740</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGS9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGS9"/>
    <dbReference type="WBParaSite" id="DME_0000671401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000671401-mRNA-1"/>
        <property type="gene ID" value="DME_0000671401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000671401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13765" checksum="C8C14205EC391BC0" modified="2015-12-09" version="1">MELLNLLALSFLLDIQTFKKDKRRLILFGIGSFIAFHIINLPWTFYTEKLDYIKLAPNSTNENTSYRRSCSRRYIWCDDIRRIPLRIYIFSTVVLSGLGFPFMSSPTGSLLSEILGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHE5</accession>
    <name>A0A0N4UHE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1551</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHE5"/>
    <dbReference type="WBParaSite" id="DME_0000697201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000697201-mRNA-1"/>
        <property type="gene ID" value="DME_0000697201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000697201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13848" checksum="91E1D89FA0F0C6BE" modified="2015-12-09" version="1">MIEDQSTTRSRSATRDRSATRGRSTARGRFATRGRSATRDRSATRGRSAARGRSATRGRSATRGRSATRDRSATRGRSAARGRSATRDRSATRGWSATRGRSAARGRSATRDRSATRGWSTTRGRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHH0</accession>
    <name>A0A0N4UHH0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9800</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHH0"/>
    <dbReference type="STRING" id="318479.A0A0N4UHH0"/>
    <dbReference type="WBParaSite" id="DME_0000700101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000700101-mRNA-1"/>
        <property type="gene ID" value="DME_0000700101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000700101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31655" checksum="B044FC8626E8E09E" modified="2015-12-09" version="1">MDSFKFRQQNSRGCVLDQPQYIGEYCVNAQRGIILGRSQARYLCNFRINRECHMDLNEGYEIFDAKIEPSNEKIDILLKWLMLHSLPGDSLKKVCHDADFVSWRGIFARIAATPSNKDEHWMFAVVCYKSVIFLCEYPTEQKLTMLANMSNRDKIMAYWGFKFEQFMTSSHPESVPDTKKPVTNKEEFHIMVKSKFNESHLKILYSAETDGLYYASGAYVELKTMRFDGQKKHSWDRKALKWFLQSYLTATKEIVVGLRDDSGYLFANYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHM1</accession>
    <name>A0A0N4UHM1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9818</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001192">
        <property type="protein sequence ID" value="VDN59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHM1"/>
    <dbReference type="WBParaSite" id="DME_0000705701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000705701-mRNA-1"/>
        <property type="gene ID" value="DME_0000705701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033661at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053291">
        <property type="entry name" value="Ommatidial_diff-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF20">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000705701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12880" checksum="CD8EF0ACB1374BBD" modified="2015-12-09" version="1">MAYTFHARINNLWSIWYTIIIVLLQSYLLYLGFERYKLYSEMKWPHGAYPRLWLKVYIILYSICVPGLVLFIASGVFKSGNIAGDNDRLGDRAERVIQSCDMQSKGFKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI04</accession>
    <name>A0A0N4UI04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI04"/>
    <dbReference type="STRING" id="318479.A0A0N4UI04"/>
    <dbReference type="WBParaSite" id="DME_0000721401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000721401-mRNA-1"/>
        <property type="gene ID" value="DME_0000721401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5786237at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000721401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14601" checksum="1D0899091BB2B0BB" modified="2015-12-09" version="1">MPRASRIVRVSRYLRALPRFLWNEYPEQVVAASTFGVGGLVAFAYKISIYSDEKVTRPYYRGSYEVVRPDDPLALIWRKPELHYIFRLFEGFQTFQDYPAPYLSNRENATSASYKKDYGWRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIF3</accession>
    <name>A0A0N4UIF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1746</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIF3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIF3"/>
    <dbReference type="WBParaSite" id="DME_0000738401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000738401-mRNA-1"/>
        <property type="gene ID" value="DME_0000738401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="4">
        <location>
            <begin position="39"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000738401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18891" checksum="DE458B0B52DEF2C4" modified="2015-12-09" version="1">MEHLDRYHAKLYAAKLIASLDDNLMNFKSINFMPLSSSKTKRSNMDSKLNDCQDIIPVDREGQLLMNISYSNCCRRMIYLDFSNTQFSGWKNSHYSNVVKGYYCFGRCPYYGEQIFDSEPKKHIFYDEFMNAHSKKLGLSPCCAPLKFDPLMVTVKYGKFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ23</accession>
    <name>A0A0N4UJ23_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1902</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ23"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ23"/>
    <dbReference type="WBParaSite" id="DME_0000763501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000763501-mRNA-1"/>
        <property type="gene ID" value="DME_0000763501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000763501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="72208" checksum="C40CCC7B08691BA7" modified="2015-12-09" version="1">MAYIPKNILITGGCGFIGSNFINYIFHKWDKTNFINVDKLILNSDARYISDDVIFSGRYKLITCDIKNSIIIKQALVDNQIDTIIHFAADCTSTRCYEFPIESLENNTISFIKFFDVIRSYGFVRKFIHISTDEVYGDSNLAADEKGKMEDSVLSPGNTYAATKAACESFAHSYRLKFGLPIIILRINNIYGPNQWDVKLVPRYIELAVNKEKFTVQGTGEQLRSWLFVDDASEGIRVTVEKGEIGEIYNLGTYFEMNILDVARKIQSEVDKQLKRQPVHVEFITIPDRPYNDLRYLLDINKVNKELGWTPKIPFDEGIRRIVESTLKPKLHSQRMKVIIYGGNGWIGQQMQKMLRERKIPFLLAKSKLGVVSDAEVIDELNEFCGTHVLCCIGRTHGGSYKTIEYLEGGPDKTYENVRDNLYSVTILAEICYKLGLHYTYIGTGYLFSYDKDHPIGGEGFKDNDLPNFYGNSYSVVKGFTDQMMKQFNGGIRENLNARITLPLNFELIDERNLLTKIIGYKQIFDIPVSITILDDCIPALLKLMEKRFGGNLNLVNPIPISLHEILQLYKKIVDPTLPDSEVFDASSDKGKHLLSTKANCTLDTTLLKEIYPGMPTSIEGLQTGFKKLTLIGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ86</accession>
    <name>A0A0N4UJ86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">All-trans-retinol 13,14-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10141</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001203">
        <property type="protein sequence ID" value="VDN60168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ86"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ86"/>
    <dbReference type="WBParaSite" id="DME_0000770701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000770701-mRNA-1"/>
        <property type="gene ID" value="DME_0000770701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052206">
        <property type="entry name" value="Retinol_saturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091:SF3">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091">
        <property type="entry name" value="BLR7054 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000770701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66384" checksum="DEAAC7510A8FA541" modified="2015-12-09" version="1">MNCTGISNDRPLIQEEIHQLLHDNFSPSKVNNILWDAIVIGSGLSSLTLSKVLSASGYKVLILEQHDRAGGSCHTFKLDEFEFDVGLHYVQNMYSGRQLFKICSAITDSYCQWQKMDDPVDMVIINGQRYGRTAGDMKEFQSSLKNWFPDESDNIDKFFDYSYQCMKEIPWLFRAKFMPLIIYKILTKFNIFDKLTNIFRCIQETLFEIMSKYNLSPQLQCVISSYAANYGVSPNQASFLQHMLFFMENGYYPIGGANILTSSIIRSINKFGGKVLVKANVREITFDGNRRVNGVIVDYGSSRVFIRSPLVVSTASIVRTFNELIPTPTAKTSFMFSIANELYSKDVVKRGGMQAYIGLLGTRNDLNLPSNNFFWFKTNDIFENSRYLSLKTMDEVIDYGCPPSMYISFPSAKDPGWSARHPNVSTCQIISLANPEWFSEFQNLRNDRSRKRKNKEKYLLLKNTIGNYLVDMVTELFPSIKNEIIFKEFSTPLTQKYYLQNMHGELYSLTHQVDRFQSNYWPYLRIKTDLPGFFCSGQDVLFCGVSSALHSGLLTASSILHRDLYKDLENAYLIQTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJA4</accession>
    <name>A0A0N4UJA4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1947</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJA4"/>
    <dbReference type="WBParaSite" id="DME_0000772901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000772901-mRNA-1"/>
        <property type="gene ID" value="DME_0000772901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868789at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000772901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="47798" checksum="040F1DBE7BB3A1D7" modified="2016-06-08" version="2">KICGSIVRPCVPKPSQCSQEKSVSKKSTTILPKLTTSATLPVLIDWPCARITPPYSQEKSVSKKSTTILPKLTTSATLPVLIDWPCARITPRYSQEKNVSIKSTATLSKLTPTPTLPKLTTTASLPVLINWPCARITPRYSQEKNVSKKPIAILSKLTPTPTLPKLTTTTTFPKLVDRPCARITSQYSQEKSVSKKSTTTLSKLITTPTLPKFTDWPCARTTPRYSQENVSKKSSAALLMVTTAKTFTTRTKITTIGILRKLTTTGTLRKVTTTGMLRKLTTTGTLRKLATTGTLRKLTTTGTLRKLTTTGTLRKLTTTGTLPHQNRPQSQQAVYQVCGVNGRIAQLLVAEVALKSEEELVARIVQEPCKRRETRFCVSEVVDCAGLDSYSAWSEWSTCSVTCGKGIKSRNRECFLHTELCTAHITESMVCGDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJZ3</accession>
    <name>A0A0N4UJZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2133</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJZ3"/>
    <dbReference type="WBParaSite" id="DME_0000800801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000800801-mRNA-1"/>
        <property type="gene ID" value="DME_0000800801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5968217at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000800801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29587" checksum="A34F5220B3CD680A" modified="2015-12-09" version="1">MLTPGYQNALSENGITTHFARSILPECGAKDIENTSPTSSYASSNYYQYSLQQNYTQQFMVKNEEDYVSQAPFCSDAYLQPAADAFIQNPRIFEKNQLSHADYDRSFIKSDNAIFGQNAYGTSPFVRPHYPHFPFSTHPMTSATSRLPTPILCQWIEKNRMCNRVFYTMDHIVSHLQQEHISNNDSSLHICHWKDCPRKGRIFKAKYKLVNHVRVHTGERPFPCNMCDKVFARSENLKIHQRTHTGPHFLLFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKK9</accession>
    <name>A0A0N4UKK9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Circadian locomoter output cycles protein kaput</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2311</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKK9"/>
    <dbReference type="STRING" id="318479.A0A0N4UKK9"/>
    <dbReference type="WBParaSite" id="DME_0000828101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000828101-mRNA-1"/>
        <property type="gene ID" value="DME_0000828101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="366"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000828101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="635" mass="71927" checksum="36A665B76E1B5E62" modified="2015-12-09" version="1">MAILKATVRMASIIENKSEHEQGLMAVTNMNTSNDAAGINLSLKVWVVMAIHLKWRNENEKRRRDAFNRLISELAIIVARDDQKLDKSNILKCTINFLKQHQHKIDGGDTILSPFSIQVRTLPVGYGIIYLASSSDVVDPPPIFQLTLWRKNLITLITSETGQTMTSAVRRGKTYNLRFLVRAESTTDDGGNNLYSELNRLVGCSVRDLAGLYMDALAVGTFCVACSGVIIRASSAFAAFFNKSVTEIIGLNLLQMLEESSAKNLNEKFTHEIFRIVSPPSILSEFPIISINIETNHHKRRILMVGWFKKISISRIHSPNADQLFEEQLGKGLSNDSDEKSQPMMCFVGIARPEYDVPSIIRTAKLKMINDFTITYNAEFKFLYTDRNCVYLLGYSNYELMGTSGYEYVHNDDLEMLAGFHQQLIHVSICQIGCHRLRTKSNEWLLVRCIATIENQSSLKQIRCTYRLADERYDLGETKNLDIETTNGVSSHQISPLSVIMQPGSSHVSQCSPATSEFFHESPLPLFSSAMNSMVSTASRKRRSEPPLVYIKHYPLPESKKGKQEDARNIVNVSSSFSKSDNDAVNSSINISPMYRHIWEELQRRSEILRQQVIQKEIELRELHIKQFLASVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKY9</accession>
    <name>A0A0N4UKY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SCHIP-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10375</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UKY9"/>
    <dbReference type="WBParaSite" id="DME_0000843101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000843101-mRNA-1"/>
        <property type="gene ID" value="DME_0000843101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260144at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039045">
        <property type="entry name" value="SCHIP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015649">
        <property type="entry name" value="SCHIP_1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103:SF2">
        <property type="entry name" value="IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103">
        <property type="entry name" value="SCHWANNOMIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10148">
        <property type="entry name" value="SCHIP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schwannomin interacting protein 1 C-terminal" evidence="4">
        <location>
            <begin position="222"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000843101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51849" checksum="7F3539AA7493F0B8" modified="2015-12-09" version="1">MEMVEMNNNSIPNSSSLCGGTILQAIVEKTPIRRRNIENEPHSRRKTSGSSGESFDNNRAFSTYSWSEDSLEMSNANSQILDFSPTDSTVPMKLNEVYDINVPYKITSTHDNDIDSTQFSQKTAESNATMVPGTNPGYDLINSPGSYTSIDCPMPSTSHSVNSFFRFSPTSSTNKELIRESIDRELDGLDTCLPNLDFNKLEEKLVIAAKERQIMERKLLGEQVRRRLALQVDQYMAGPSPRILTRPSRSNLGFRLQTAMNLQVCYMNDLTDDENEDDDDEVGLDSSDDELPKSKSAPNLCYTTTIQDGSNMNATQLRQKSAMEGNPRLLLEEETKLMLLKAKQAAKMQMELERLNTHRAIYCGNHRKFFRIQLTKMSCKQLREISSQLNARIEEENAELVRLLVEKDSLHMQQDSMLVDIEDMIQHENHSEILNLPEFLMVQPGGEDAKFRVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULQ4</accession>
    <name>A0A0N4ULQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2629</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000071">
        <property type="protein sequence ID" value="VDN52656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULQ4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULQ4"/>
    <dbReference type="WBParaSite" id="DME_0000873801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000873801-mRNA-1"/>
        <property type="gene ID" value="DME_0000873801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15627at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032034">
        <property type="term" value="F:myosin II head/neck binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551:SF3">
        <property type="entry name" value="LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551">
        <property type="entry name" value="LIM DOMAIN ONLY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="491"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000873801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71162" checksum="4EEFC46EEA6205BA" modified="2015-12-09" version="1">MNLDDDPGGRFPKIVRNYDVTRESIEALSHLKKMTIEQNEKNSIYSYFRCSQQKPLLPPTPPPNKTIPQDENFENINRSDRSCLKRYHRVSTEKSKSTDNLRKCIREITIEKNDNDHTANLPQPTNHTSSGNPTKKRVVFKTMEDDFSAGIQIAPKTKNYRSSEEGDESSALIASYGFKPNKSSVQRIHPIQLINHNDQEVMNRKVITDQIGQRSYRPIRIFVKDDVSQTKKIPIRTRSYDDLLDDEKYLPRNSEYFMSDYYNSLDKTRWQSSTFNQQMMSKESCVKNNVQKTLTTRIVQSFPTSPSIKHSTELMKDGEKYKEHEHIWKVPELIETVDSREWKQIVTQQRLPSPGDSSSKNTVDADLRLRLSPKANEENKILYSKNCHFSGVSKLSSHYFPRNNSANAPHNNKSECNAKYSKDQSHSLISNHWMIKESESPKRLIEQLRQPTIEISVNSYSCKLHGILAEVNGSLSRMKTNEQVVSVSGKHKCSHCYAELGMSCILHIYSFTIIIVVIIIITVSNIGVAIITVTEIKTKKGRGAAMIIESLNLFYHLSCFRCYVCNKTLGNGTKGADVRVRDDKLHCQTCYSNDDAGLAGLKLSMSTLLLIDSLRSPIPYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMU5</accession>
    <name>A0A0N4UMU5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2929</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000090">
        <property type="protein sequence ID" value="VDN52956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMU5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMU5"/>
    <dbReference type="WBParaSite" id="DME_0000919201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000919201-mRNA-1"/>
        <property type="gene ID" value="DME_0000919201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5773536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055987">
        <property type="entry name" value="DUF7565"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24446">
        <property type="entry name" value="DUF7565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000919201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12188" checksum="824581C44613AC82" modified="2016-06-08" version="2">MNSLTVIITIKIMKIIASKFLIIVNNSTRNIYIIIDRAIMWHCAACSSITSNYETIDELETHIASDHVNYLPYECEKCRYSKFPTEYALMTHCTKDHGLKEFHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN70</accession>
    <name>A0A0N4UN70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GPS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3060</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000101">
        <property type="protein sequence ID" value="VDN53087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN70"/>
    <dbReference type="STRING" id="318479.A0A0N4UN70"/>
    <dbReference type="WBParaSite" id="DME_0000933801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000933801-mRNA-1"/>
        <property type="gene ID" value="DME_0000933801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="320"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000933801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58058" checksum="E383B97A7D882A07" modified="2015-12-09" version="1">MTFLCFSLALTGDFIRVISKAEKLEEILNNGNYTYISIAATHDIKQALYCPEAKFGEITFPRSAACSKVALPCSIYNDTDGSLRYAIQHCDCKTGKWLAQPNLDNCTHKWTMEFEQAISNNEPAEILSGLLADKLKSTIQFRFSDIVGSVNVLENLIPLAMQQYVLIDNRTERSQKAIEFTQAKDNSFLKSNLFGAAGDELLSSRVEITWMQLGTRVRIATASTLMISLERSAALMATFLDQKQKKINYRMQVQVKSPGKTTNRIAAFDDSSSKKLQQSLSLPHVPHDDHQNSSFNPELGVPLSSPAFYKASVPATISFSDFQLSPNNLLIKQVLRPKQQLFRISSILKYNLDTTETAVSLDRNPLRLGYYIFKSFGNLLNTDNKTIINSLIIGASVNNPTQNLELPKSNPVSFTFYHIKQKNVANPRCVFWDTNKRIDVEIFNFLRIWNESGCSVLQTSINSTDCLCTHLTSFAILMDIIGEDDGSLNSFALNVISILGCSLSAFCLFLTIVVLTCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN79</accession>
    <name>A0A0N4UN79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DCAF15_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3069</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000101">
        <property type="protein sequence ID" value="VDN53096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN79"/>
    <dbReference type="WBParaSite" id="DME_0000934701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000934701-mRNA-1"/>
        <property type="gene ID" value="DME_0000934701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000934701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65918" checksum="87B5ACFD254B28C1" modified="2015-12-09" version="1">MTEHFFEGIVFECDKERVISVYSPLTGLVEVKKTQFSARDIRPSFGRSCSFRLNFKNGSCCVTTLRILSTSRLKIIESPSLFFQSIGFVVNKVKPGCIWSDILGCIYVENDALLEDFELFDTIKFTAYCSSTKNILFKANAVERSSVSTFQSEVLKFKRSATVNSDNTIKISGLKVHLNHHLEKWCHLKQPIGEDYDFSRKNVSIIYYRQFKDQNIDAVALFITNRSELKEGIFSTERSMDSRIMSFDIFNAVGDEQSNFNYKILASEIEKDLIIEESSSKDQCKQYEQYDEATYSEHTSNIEDNDEWGLDADILDPQMLKYINERIPKGKKSFNSTNEMQNFKSNNESNIDDWSLTASRRILREDNAQQSFDKKDGETNNNHTDEQKVDRLCTNYTRMKIRNAKFSKCFVRKNKPFSNIFLDSPLYPGHKNIRNSITIVPALPNFNTVIMNDSGCDDNSKHSFFREVDSFFGILLTDSYIRAYICASRNGSYLLLAISDFLCRKRITNVEFYKCFPEKNLPETLSELEYFEIMCALICDRLMQIHGFSQILRFNLRLTPILRKMLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNU0</accession>
    <name>A0A0N4UNU0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">26S proteasome regulatory subunit p40.5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3262</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000118">
        <property type="protein sequence ID" value="VDN53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNU0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNU0"/>
    <dbReference type="WBParaSite" id="DME_0000959501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000959501-mRNA-1"/>
        <property type="gene ID" value="DME_0000959501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="145"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000959501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42659" checksum="E5DDB21A447D7741" modified="2015-12-09" version="1">MRISFFRLWHQLTVELGKVVVDEEFIKSLDLNEFYENFIWDFEHRINPLQLVEIVIPVAKYIFVRKDKESAYEFLKKIEKTVCKDKAAVVRVWTGQIELRLMHKDKADRCVDIQIIRKLIEETQEKIDELQGVTPVHAPFYKVSSTYLKEIGNYAAYYREALRYLGCENPDNLSQTEKQLQAVLLGFAAMLGNDVYNFGELLAHPILKSLENTQEKWIIDVLYAFNCGDLKTFRRYKNQWCEWEDLQKHQMFLEEKIRLLALMEIAWARPSKERFIPFSEVAERAEIDFDKVEFLVMKALSKNLVTGSIDQVNQLINIAWVQPRVLSKEQIMAMNDRIGMWCSEVEAMQTLVRENAEAILISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW2</accession>
    <name>A0A0N4UNW2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10708</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001238">
        <property type="protein sequence ID" value="VDN60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW2"/>
    <dbReference type="STRING" id="318479.A0A0N4UNW2"/>
    <dbReference type="WBParaSite" id="DME_0000962301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000962301-mRNA-1"/>
        <property type="gene ID" value="DME_0000962301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000962301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37729" checksum="BEC390783CF22E09" modified="2015-12-09" version="1">MKNKRKTISGWIISVFQFKCVPRPPDDTVQALKFNPQIAGHPVFLVSGSWDSVIRIWQISETGQCEVKAQQIVGGPVMDLEWLDDGTKIFIASADEKIYLWDLVPNQITVIGKHDKPVKSCHWVNSTNYSCLMSGSWDKTLRFWDIRQLSTQTSLATVQLPERVYCSDMLYPVAAVGLANRHVKNRCIAIFRDKIGLPTGFALGLTGGRVAIQSIEASNLKDNFTFKCHRSPDLINGFQEIYAVNDLAFHPLYGTLVTVGSDGRIVVWSKERRIRLKMSSALPQPVTRVTIHPSGQVMAYAIGYDWSKGHEGYNAANAGSKIYLHTCGEDMKLKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPF4</accession>
    <name>A0A0N4UPF4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3421</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000132">
        <property type="protein sequence ID" value="VDN53448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPF4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPF4"/>
    <dbReference type="WBParaSite" id="DME_0000983801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000983801-mRNA-1"/>
        <property type="gene ID" value="DME_0000983801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000983801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14918" checksum="CB4487ABD8BFCA1E" modified="2015-12-09" version="1">MASQTQGIQQLLAAEKRAAEKINEARKRKAQRLKQAKQEAQAEVEKLRQERERQFKEFEQKHLGSKEDIELKIKQDTENTIREMEKRVNENKQQVIVRLLQLVCDIRPEMHRNLQIQKKLHGMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPX7</accession>
    <name>A0A0N4UPX7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ammonium_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3566</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPX7"/>
    <dbReference type="STRING" id="318479.A0A0N4UPX7"/>
    <dbReference type="WBParaSite" id="DME_0001003901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001003901-mRNA-1"/>
        <property type="gene ID" value="DME_0001003901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001003901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42275" checksum="6C6642ACE407CADC" modified="2015-12-09" version="1">MLNQTYKMQNMQKLYLVFQDVHTMAIIGFGFIMVFLRRYGFSSVSFNLLLVCFVIQWSMLIRGFFSADFAKDGKFPISIIELIKADMDAITIVIAMGAVLGKLTPIQYVIMAVFGVPLAVTVDHIVFRFLMVNDVGRSLVIHTFGAIFGIAVARGFVSPVTFEHPHKGSNYNSDIFAMIGGLFLFIFFPSFNAALASPENARHRAILNSYLALSACGVITFAASQTMDREKKSRFTLRHIANSTIAGGITIGTVANIILEPVFAVLVGCLAGFISVFSYQIITPALLKKLRIDDTRGVFSSHALPGILAGILGFIFAFIYDPTRYDNFLYLGLLLKLKFLNQIRDKEFFSDFDIFDVPEDFDFTTRVNFIRLFSSNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQM3</accession>
    <name>A0A0N4UQM3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000190">
        <property type="protein sequence ID" value="VDN53837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQM3"/>
    <dbReference type="WBParaSite" id="DME_0001031701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001031701-mRNA-1"/>
        <property type="gene ID" value="DME_0001031701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001031701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9271" checksum="886C6788FDA31E56" modified="2015-12-09" version="1">MERDDVPEKIIRLKKAFYERTSVQVCKYGEMTDSFETRLCPFPYNMQLCDRSDNEPLVGAQEVSKSVQSTVSQILNTLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQP3</accession>
    <name>A0A0N4UQP3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3827</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000195">
        <property type="protein sequence ID" value="VDN53854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQP3"/>
    <dbReference type="STRING" id="318479.A0A0N4UQP3"/>
    <dbReference type="WBParaSite" id="DME_0001034001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001034001-mRNA-1"/>
        <property type="gene ID" value="DME_0001034001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF6">
        <property type="entry name" value="RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="158"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="852"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001034001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="117056" checksum="A119EA7680549DFF" modified="2016-06-08" version="2">MINLVRKTVKMILNATRFQTFKVKTLVEMKPTTSKVYIDDHTPDRPQIPFYYTTRKSRSAADILSTCSQKDDYYLYQEVRFRRDEASKSIVMKSNYDYNPKNGDELKLKRGSTIRVLRRDCDDGWWYGETEDGRKGFFPQNHVQLAPGKVNEINNDELQYTGLLGSGGFCVVKSAIYKNKNVAVKIPHSKFSEKEIRQAVQEEASIFQMLSHENIVEMYGVLVGAKFGLVFELCCDSLSSVCSSSKDILLSEEIISYWGLQIAQGMKYLHDLNVIHRDLKAANVLIKEKVCECLLSMRPNITEQVAHSMKSDDGVCYKCGGSALNRLTLKIADLGLSKRIQVTDCSFVNRMSVVGTVPYLAPEVIRDRKCSKAMDVWSFGLVLWEVLTGAVPFEGLGQGAVQLQIGTFVKQKIPSSCPPDLKYIIDWCWMDDPQQRPTFKELTVQFKKFGEKFKTIDLHDQKFLENSMNTLRKSMMEEIAAIADEMMKKANELQKREEKFEYYRLNALCLNYFFKSLSSLKKGERELKLNQMIFELQQTLSREAPKEKPQPPKRRPHLKCSDISEPFDCKTEISLTKDLQMIKFVMIFSMPSYPFHYHEEASIIVVMCCVCIVISAPNGERSSSTSNGISNSDEQYSECVMSGFATLPRTPKKLSFPTETHEFCFPPKVDSKIPSKSQPDLVKLYRQRININNISPTNSNCNTLHRVNACRHKKERTRDLDRADYVDEECIVVVSDADLEESLQEKDDCRQSSIDHLATPRRVQMNLSSRNNNHARSVITTEKNSGSKGSDDDKRFFRNFFKLMDKSPNRSGTWSLPRPTIMAVPLGSTTVGSSIISKSLVTSKYQGTFAKNTKSNGKKTTVKPKKKSKQSAQEKDKEKDKFVLTKNSRIFVKPNSGERRMSLVSSVANTFRNSNYLACDDSSNNNLRVDEPYEKLSDASDGSLLENPSYIPPSSYLRGRASTSDISMWSSRPITSSRSQSSSQTSFDDPVPCSSFGIIENLSYRPPSDMKLRIPTSTPSNIFLMSLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR85</accession>
    <name>A0A0N4UR85_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3988</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000239">
        <property type="protein sequence ID" value="VDN54015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR85"/>
    <dbReference type="STRING" id="318479.A0A0N4UR85"/>
    <dbReference type="WBParaSite" id="DME_0001055801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001055801-mRNA-1"/>
        <property type="gene ID" value="DME_0001055801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862080at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001055801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27628" checksum="22A3D899C13F1BE3" modified="2015-12-09" version="1">MRIRSGNWLEGSRIPISAVIRFIYCWCQQLTSIEWCQRELKLSNDATIDWNNRMREVCVSAVQRNKKKIGGDGLTVEIDDNLFNKRRNNDEKPLPEHWIFGGICRETRDMFIEEVPDRSANTFLTFIKKNVEEGSIIYSDFLCSYRIEELNEAGFEQLKVDYRYNFVDPGTNTQCIEKLWETWNKKHRGTARHHFNTYLAEFLWRQNLRDENVFHAFLKEVKEFWPPAKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URF6</accession>
    <name>A0A0N4URF6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4057</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000264">
        <property type="protein sequence ID" value="VDN54084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URF6"/>
    <dbReference type="WBParaSite" id="DME_0001063601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001063601-mRNA-1"/>
        <property type="gene ID" value="DME_0001063601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781148at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001063601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35195" checksum="2249C2EE20350AFB" modified="2015-12-09" version="1">MTMCVLHCVCANAEFIQMNEEHFKNPQDSVQSQYSECKKENCTIGETIVDYGCKRAEMKCATNMKFKVISELKSNGAHRLTKCFLRCECDSNNFIEKSGKCIKKAPSEEAKCKQKNCALGEIVVDLSCVKTGMKCGTNMVFKFIIKLESWRGTAFLKKCIMRCSCDNYFIEKSGQCVRVIDERVPISSIQPSSNHKTTAYSPLLYENGNCLRQIICDACNPIGNKCGTNMVFDLVYENHSGDSCLMRCVCNSESVDVNDGRCIESSLINEKTMPKFIARRYITEERIEFELRITDGTTRSPRYFYLAQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM1</accession>
    <name>A0A0N4URM1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4114</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000303">
        <property type="protein sequence ID" value="VDN54141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM1"/>
    <dbReference type="STRING" id="318479.A0A0N4URM1"/>
    <dbReference type="WBParaSite" id="DME_0001070301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001070301-mRNA-1"/>
        <property type="gene ID" value="DME_0001070301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000454">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001070301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37224" checksum="45895B3BA258CB3D" modified="2015-12-09" version="1">MSDLSLILDRVEQKRPFYLYTGRGPSSGSLHIGHLIPFLFTRFLQDAFNVPVIIQVTDDEKLLWKGITLDEARKMANENIKDIIACGFSPDQTFIFTNSQYMCPAFYGNVLKIWNLVTNNQVRGIFGITGEDSIGKIAFPALEAAPCFSNSFPEIFNGRTDIPCIIPAAIDQDPYFRMTRDVAPRLLYPKPAMIYSSFLPALQGAQSKMAASEANSCIYVDDTPKQIKNKINKYAFSGGRDTVEEHRKFGGNCEVDISFQFLRYFMEDDDKLENIRKLYTSGDLLSGELKALAINEIQKIIGEIQTERKKISDETVKKFAAVRKLKNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q380</accession>
    <name>A0A158Q380_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6194</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q380"/>
    <dbReference type="STRING" id="318479.A0A158Q380"/>
    <dbReference type="WBParaSite" id="DME_0000183401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000183401-mRNA-1"/>
        <property type="gene ID" value="DME_0000183401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF68">
        <property type="entry name" value="RETINOL DEHYDROGENASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000183401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="580" mass="66906" checksum="64BDF3FFAD1AC693" modified="2016-06-08" version="1">MLLHWPLSIINGLYFHIAETERKCFIEEIPDETMVTANYKVLLYDPNTKGYGEYPNIGMHVEVKDPEDKIILSRLYTSEGRFTFTSHTPGEHVICLYSNSTSWFSGAQLRVHLDIQAGEHAQDYEQIATKDKLNDLQLRIRQLLDQVEQISKEQNYQRYREEKFRQTSENTNSRVLYWSIAQTAILIVTGAWQMRHLKGFFEAKKLFMRRIVAGLTSPWSLAFSAFGVSYGIYNLIDITQSGAPYELNEDLTGKTFIVTGATSGIGRSTCEELSKHNARIIMACRNREKCIKVRRDIVLNTRNKQVFCRHCDLEDFDSVRMFVEKLYSGKFKIDRIDGIVHNAATMEPTRTVNKDGIERTLATNYLGPFLLTALILDKLFAQTNPCRIVFVGTNVIDRKCEVNLDDFNSEHCKKWDGYNVYKESKLALAAFAKELSERVKDTNVVVTMADPGRTKTALSSKMPSQSFFLSRLLIKPVSFFMGERRVEKAVRPVVYALADPEMAETNGIFIDRERKEQPWCSGVMDKQFREKLWCTSEKWTRLSGQRETFLKSIRGANENSTTKSKETSKLWKIWPWQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3M9</accession>
    <name>A0A158Q3M9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7080</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3M9"/>
    <dbReference type="STRING" id="318479.A0A158Q3M9"/>
    <dbReference type="WBParaSite" id="DME_0000272001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000272001-mRNA-1"/>
        <property type="gene ID" value="DME_0000272001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="GH84" evidence="9">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000272001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="820" mass="93903" checksum="5BE9E9890FC6C7F1" modified="2016-06-08" version="1">MENFKSFEKMKRLFIYQLSAKKPIVHGFYGRPWANDQRQELFRWMQKFGMNTYLYAPKDDIKHRYDWRKLYTTEELDLLQSLINAAKEYKITFVYSLSPGLDITYSSDKEVQAIKDKFDQVKSIGCEAFALLFDDVDAIMHEVDKSKFSSFAMAQVTVTNLIYEYLKCPVFYFCPTEYCESRAFPSLQESEYLSFLGKKLLPDIYIFWTGPRVVSRSITIEHMRSVADILKRKPVIWDNLHASDYDAKRIHLGPFTGRSVKLKDEIAGLLMNPNCRLEANFVPLHTVAEWNLCEDDAELDGAFDSDAILEAGDIAVVAAYIVEGDKSKRLYHPLNALNEALKKWYERLFTEVEITPSCQMETEALTSIVEKPPFLDSNTGRPLYKNLGNMLTQSSSDPQMKPTICAMNSLSPDYSEPMDLITLAKDEPKILVDSDSSNKMNNQDMVDTSSDVSMESSITTDSGGSVQPEHLAMFVDLYYLPFEHGRSCIQILEEFTWLHENSFVIKKKKEASENKNVQTIINEDWKRRCDSLLRLLHNLTKFYQLLTALPNKAAVQDLFQYVYEIQGIASMLEVILLWMADGGLTSAPRDSDYFWRKPMIDGEPWIVSGGSVSDLLKLLFVTPNIMDLITLKSVIPLFLNCLTMRPYRDKDEKEIYSLYAQDDSLSTNFDFSNDCKSEQSFDSQIVPFLSHSEPRISFVAVENSSYGKRITAFSCAVLKAKEFSKNVQNAYTSKTQLNYEASPEMEENDCIEGSKLQSEEIDSCVSLQLSDQFYEHFPSQVEIRWRSTNHDAVAVRRLICASAAALSFNGLIFLILIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q474</accession>
    <name>A0A158Q474_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8048</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
            <location evidence="4">Sarcomere</location>
            <location evidence="4">M line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q474"/>
    <dbReference type="STRING" id="318479.A0A158Q474"/>
    <dbReference type="WBParaSite" id="DME_0000416501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000416501-mRNA-1"/>
        <property type="gene ID" value="DME_0000416501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09339">
        <property type="entry name" value="LIM4_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000416501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28584" checksum="E597B3D9BEEA1513" modified="2016-06-08" version="1">MIIEKRALQTEMHVTGQIFTDTTENWLRTRLKSVSTEDMQKELTKVRDDQKQNAVTDTLAALVYDIDATAEVLRRGSMKKKKKDQEGGEIEYKLRLTPGPEEDNPPFPSPKSRPPAEDSFTLEQVSRDYGVEMIESQTGSWKKRARSETPRRTINIEGSPQPSTLPLCAFCSEEISGPIITALAPNSYRAQKFHPYHFMCTYCQKALNLRGTYREHQRKPYCHECFYRLYNGLIYAPDEKQAKIEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4L3</accession>
    <name>A0A158Q4L3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8953</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4L3"/>
    <dbReference type="STRING" id="318479.A0A158Q4L3"/>
    <dbReference type="WBParaSite" id="DME_0000515401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000515401-mRNA-1"/>
        <property type="gene ID" value="DME_0000515401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250701" evidence="4">
        <location>
            <begin position="16"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="75"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000515401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="791" mass="89505" checksum="8418C25CB0BC58FE" modified="2016-06-08" version="1">MLLWILVIIFDSQLAVLVDWNTDIVATKNELMQSRNDALWQYFDSIVESDELFKSRDAMKKIIGEFKDVDRLKMVNHNYETMTQWLNDFAKRFPNITWLYSIGESVENRSLWVLCISKSPKIHRVGVLGREALLYFAYVLCENYGKNEYISRLINNTRIHLMPSLNPDGYERGFAGDRTSEMGRANANNIDLNRNFPARYPWHKENSGSLVANYPYDDSDSGKDGIYSPTADDRLFTALAYTYARSHTKMWKTGRRCGLNIYGDSFSNGITNGAAWYHLAGGMQDWQYIHSNCFEITIEMGCFKFPYNQMLPQLWDEHKYSLFAFLEFVQRGIKGFVFDILGNPIANAILSVNQGKQIKTTTDGEFWRILLPGKYEVNVSHPKFQSKLLKVEVKNGWATELNVTLEAKTCPLASNGIYLQGSGPIRIAVLGIDSFSNAVIYSMLNATCSGSKLFEHFINNTTVHILLPYTSSQHLSYLKSHELDVIFILSQGLPRSLIFSANENNPPAFNKSKLDYSFKMIFSNESPICRNNLLDSKVSSMVDLIGLSKAFEIGISLGCPSNNNTDSVIALAATLQTISGLYREAQSKVTEHFVPTDHSLPPETSVTNARIEKIRCGSFIDIDDMKTVIIGSGRGPKILLMSIEERTETLVYKLASQFCMDEKSNVNTKLSVLTNSSTIIVVPELAHPQLYCHDYNSVAPLELMLKKFLNRFPSIDYIIMYATGGLKVRYIERSGHVERLAREYVLQHNSMNLGAADVCRSFLCSSHIVLFPEIAKRSCGDILRVSSTDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4T6</accession>
    <name>A0A158Q4T6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytoplasmic protein NCK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS738</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4T6"/>
    <dbReference type="STRING" id="318479.A0A158Q4T6"/>
    <dbReference type="WBParaSite" id="DME_0000569301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000569301-mRNA-1"/>
        <property type="gene ID" value="DME_0000569301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11766">
        <property type="entry name" value="SH3_Nck_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000061">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="251"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000569301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40107" checksum="70048A64F078FB6F" modified="2016-06-08" version="1">MVDDTYVIVKYDYYAQERQELTIKKNERLKLIDDSKNWWKVVNEDNMVGFVPSNYVRKESFVDKAKGTIKGFGNKSKKFPMDNKQVNGIILHLLQVENITSYAVAKYSYEPQREDELRLSKGDVVTVTEKSSDGWWKGQCHSQTGWFPSNYIDESPPNTYFSSSKAPCNISSVISVVITLYSFDAQNAEELSFRKGERLEITDHPAHDPEWWKARNSKGSTGLVPTNYIEQVLKSKVSPAKLSGPYSNQPWYYGKVTRDESDALLNQRGIDGDFLVRDSESNPGDYSISLKATGRNKHFWVQVDNGNKTFKIGTRIFTTMDALLKHYMASPIYTNDKTNERLFLIKPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q530</accession>
    <name>A0A158Q530_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1235</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q530"/>
    <dbReference type="STRING" id="318479.A0A158Q530"/>
    <dbReference type="WBParaSite" id="DME_0000633801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000633801-mRNA-1"/>
        <property type="gene ID" value="DME_0000633801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF12">
        <property type="entry name" value="SPINELESS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000633801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41583" checksum="F5920FDA28A9282A" modified="2016-06-08" version="1">CLHRSPYITNFPFAFTHTYPYFQDISTNHCDGIPSMVHASTGHSFVDPKEYDFETMALKALGGFILILNENGEIYYASENIEIYLGFHQSDILHQPLFEMIHSEDREDIKNQLSWNYNVPPHITNFQDLLTPAGIYYLERNVNARFRCLLDNTCGFLRIDVRGKLMSLHGLPHSYMLGRTEMHPASGEIVLGLVAVCSPFVPPTIIDQPFEDPILKTKHSIDMIMISTDNRMRLVLELNDKHLPYSFYTLVHVDDAICVAEAHKEVMKNGASGLLIYRLISVQSQRLYWIQSSCRMFYKNGKPESIGMTHRLLTEVEGTMLLDKRASLKTKLLSFDDSLLQSPQNLQSTAALPSTSSGMLFESTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5D8</accession>
    <name>A0A158Q5D8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9840</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5D8"/>
    <dbReference type="STRING" id="318479.A0A158Q5D8"/>
    <dbReference type="WBParaSite" id="DME_0000711001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000711001-mRNA-1"/>
        <property type="gene ID" value="DME_0000711001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000711001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="65381" checksum="1D7793E354ADA025" modified="2016-06-08" version="1">MNTNAFRIRGKEMVDYIADYMENIHKRRVVPAIEPGYLKELLPKSPPDSPEKYEAIMEDFEKFIMPGITHWQHPRFHAYFPAGNAFPSILADMLSDAIGGMAITELEMVMLEWFGKMIGLPSDFLPFTEGGNGGGVIQGSASDCNFVSLLAARFEILKELRQRFPFVEEGLLLSKLVAYCSKEAHSSVEKACMISMVKLRILETDSKFRLRGETLRMAIQEDRELGMIPFFVSTTLGTTSCCSFDVLSEIGPLCRDNDLWLHVDGAYAGSAMICPEFRYLMDGIEYAMSFNTNPNKWMLVNFDCSTMWVKDRFKLTQALVVDPLYLQHGWMNKAIDYRHWGIPLSRRFRSLKLWFVIRMYGVNGLQNYIRNHVRLAKKFEQLIRADNIFEIVGDVIMGLVCFRLRASDEINKALLTELNSSGRIHMVPASLNDRFVIRFCVCAENAVERDINIAYDIISQTARQIIRNSINEPLVEETELETIDESAAKLDSSLYRLSSNNLVGDNICDLSKDDLLKKKSSQTLEQKRSFFVRMVSDPKCYNPKIIRHLSRQNYRKMCEEVARDCSLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Q9</accession>
    <name>A0A158Q5Q9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2131</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Q9"/>
    <dbReference type="STRING" id="318479.A0A158Q5Q9"/>
    <dbReference type="ESTHER" id="drame-a0a158q5q9">
        <property type="family name" value="Neuroligin"/>
    </dbReference>
    <dbReference type="WBParaSite" id="DME_0000800601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000800601-mRNA-1"/>
        <property type="gene ID" value="DME_0000800601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="11"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000800601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="81843" checksum="74EE0C053F3B5777" modified="2016-06-08" version="1">MIYFRCFYGTRKVTTTFGVLRGDSVNPGIDELPPVSQFLGVPYGVAPLGLYRFNMAISAAKWTHLPKNASNLSPVCMQSGIPEIAEAKALTATSAQRYDHLHRLLMKLRPQSEDCLYMNLFVPERIESKNNRLPVLVIVHGDEYGWNSGNHYNGTTLASFGQIIVVTLNYRLGVFGFLGRCESDSCSGNAGLSDIVAALKMLSNTLPAFGGDPSLITILGWGSGASLVSLLMASPITQPNNRLFRRAILLDGSALAPWAINKNPQPIFLQLAEHLKRKSVDQVLRCVQEQSAENVTFASRKILQPTFLSVFAPIIDGQVIPNKPEILFGAQFGTLFRNIDLLVGMSSNPAHYLIPNDDLKNGVDKEKRLKIFRTLVRNLYEYHRKEILAAMINEYTDWDNPKEHPKAMRNGVLSALSDVLFTVPTIETARYHSLDETKHISNTFMFVFAHETKHLMNEVPNSGIRGSLSGDHIPYILGYPLNTGKNALYYGFNPEDREISRVMMHYVSNFVKSGDPSKPIPLSTETKVAERFYSTAWPQFNQATREAYLEITNRPLVKNYYRNAQVGFWYGFIPQLHSTGKNDLLIPEEHNFLPNHFKKETFFGVVRPYASYANDPFPPPPPPPTPIPESLQKLTTLLAAQNSTILSVTVAVGCGLLFLNICIGYGLYRQAMMNFFFSQEPLLSSNKALIGSLRPGISPTCPKHGRAAIAIARGRVNSVGSIGMPNVGLTLEEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q635</accession>
    <name>A0A158Q635_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10537</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001223">
        <property type="protein sequence ID" value="VDN60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q635"/>
    <dbReference type="STRING" id="318479.A0A158Q635"/>
    <dbReference type="WBParaSite" id="DME_0000898601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000898601-mRNA-1"/>
        <property type="gene ID" value="DME_0000898601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000898601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40710" checksum="16C4E7C424DA52F0" modified="2016-06-08" version="1">MVQIMALKSKGSAPVPNPVVFRDGDGALQILPALIENIPEARLNLIIFHLKRDDVQSAFNLAIGLKAETPQEYLLKAITYCITGYEKSSNKHLETAREYFKVVGESAAECVKFQFFYFHELIAYSSYSDMHKPGHEWQILKNISNEYFQTNKPIEISDTIAGRQAMASAYFLMEQFDKVLIYLNSIKTYFYNDDIFNFNIGQALLACGNSIEAESSLLLVANELLKKQFPYIFSLARSYIFNGKAAQAWQISTRMKQSAENFFILRMIANDCYKIEEYYYSAKAFDAMERIEPNPEYWEGKRGAVVGLFKLVSEQKAPPEQLKEALVLLEKSRHPQVEQIANAIRKYCKHNDMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6G2</accession>
    <name>A0A158Q6G2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3543</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000147">
        <property type="protein sequence ID" value="VDN53570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6G2"/>
    <dbReference type="STRING" id="318479.A0A158Q6G2"/>
    <dbReference type="WBParaSite" id="DME_0001000301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001000301-mRNA-1"/>
        <property type="gene ID" value="DME_0001000301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872647at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:receptor-mediated endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AMN"/>
    </dbReference>
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        <property type="entry name" value="AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995:SF2">
        <property type="entry name" value="PROTEIN AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001000301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38907" checksum="EECFB200A0016F0A" modified="2016-06-08" version="1">MASDDVYFVDTGPRSFFNGSNWWLPPMGQNNPVLHAARIPSNEDIAVMDADNAGQMLVETSGSIKSLEFSNQNFSAKSFDHLLNTVEMRFQFLLGIEYNSEHDRSNESPKSLVKLFDDSPAYDNLAGQFNKNLEYNVMAAICKYETCTVRNDNVCDNTIKPVGHCCNICGSLVNFKSLTVDFNKMRLVLRNFELNNDLVKQFNLSISFLRTDNEDHIPHYQIVVLNRAKDCLDHTIDSPFKKSLDLTSPLHVFDVEEFHSIARNKYGALISASNIFILLSIVIFALALMTRCKKVNINFNRLHTATSHSTAVYWAKKKSYNDEQLELMNNDQAGPSNDYSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6K2</accession>
    <name>A0A158Q6K2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10869</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001263">
        <property type="protein sequence ID" value="VDN60896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6K2"/>
    <dbReference type="STRING" id="318479.A0A158Q6K2"/>
    <dbReference type="WBParaSite" id="DME_0001033101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001033101-mRNA-1"/>
        <property type="gene ID" value="DME_0001033101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF243">
        <property type="entry name" value="P-GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="272"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001033101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55052" checksum="62F29FD29280F661" modified="2016-06-08" version="1">MRRVDHVREYDPCTYTFGRAAEFIVDKLRLRALRNILHQDSGYFDIPAQSHAMMVTRISIDAPNIKPALDSRMMQIVNNFASIIVLIILAIIFSWQIGLLGFAMFCALCLMQYLIANLMQKYNKQAIKEDLTGQLAIEIVEQVRTIQLLTREEYFHMLYDKKLSDALRLYKKSTPYEAFQFAVVSSFLYFADMASYCLGIPLIYYGYTEPISTFTSAISVATGGWALIMVAGCLNTFIMASSASDSIFRIINAKSVIENINERSCPKIDGEVQFKNVRFSYPSRPTSPILNGLSFTAHKGQSVAIVGPSGGGKSTIIALLERFYNSTSGEMQIDGLTIDQLSLRYLRDQMALVGQEPVLFSGTIAENILLGTSDKTMDDAYDTEVGERGSQLSGGQKQRIAIARALIRNPKILLLDEATSALDAESEKAVQEGLENASTGRTCLTVAHRLSSIQFADRIFFVENGKVIESGTHQELIEFDGKYADFIRKQDFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P443</accession>
    <name>A0A3P7P443_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P443"/>
    <dbReference type="STRING" id="318479.A0A3P7P443"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="214"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="466" mass="55048" checksum="442227A52FFBE186" modified="2019-02-13" version="1">MTTFERIFLVAGLRVYRILCDHFNQLLDRGWCRSGCYLYKPNMEKTCCPQYTIRLDIHKFVLSRSQKRVLRRMNDFLLYDKKPKSHSKEKSSDSKSNCQATKQLQTSVNDSKSPIIQTEFKKSERSLRGTKKKQIRKERALQRMRDKGIDVDEVYFKFEAGIIVFQQKRIEKEFARRRTLHSYVLDNEATTFKHRLEIRLVSVNSEEFESMLNESFSLFEKYQSIVHHDEDRSLEGFIRFLVKSPLFSSEDETPSGVIIFSKQNIIPPTYALGSYHQQYILDDQLIAVAAIDILPRCLSAKYLFYDPDYDFLNLGTYSALREILFTMELSKYRPDLHYYYMGYYIDSCPKMQYKSQFRPSDLLCDYSFTWVPVEKCVERLRQSGKKFVVFAPDKSPPKQIPVKSVLCSYEWYVFNVGFIYSKKKGVVLPYGSLLRRPNFKETESFMEEYARLIGPLAKEIILYRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P4A5</accession>
    <name>A0A3P7P4A5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P4A5"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="113" mass="13783" checksum="C15EAFE443B4A9D7" modified="2019-02-13" version="1">MHLLQLLNIIFQNDALWSIHLLIYLMTTILCWIKYPRNVVFRFLTSFITVFGWIFVIFIIWTMNYLSKSTIKLQYNEVFFFFFYHIDLRSHFISLGFIIINTIFAFLAFVPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PEH4</accession>
    <name>A0A3P7PEH4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PEH4"/>
    <dbReference type="STRING" id="318479.A0A3P7PEH4"/>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="114" mass="12924" checksum="C7F1F34E7E395433" modified="2019-02-13" version="1">MKCCKERNVDVKCESRCNFDILSRRVLMAMFIGSDPCPQNHGRDLMLCAAQKLDHTACCKLKGVSRTAAGEKCLGFCRMTVDNRFQIDLSMLPCWAVLNDIKDCFKEEIILKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNB6</accession>
    <name>A0A3P7PNB6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7847</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNB6"/>
    <dbReference type="STRING" id="318479.A0A3P7PNB6"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF810">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="245"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="494" mass="56315" checksum="513AF940F49E911C" modified="2019-02-13" version="1">MSINNPDEYFQPLYNKWDMSRPISYEFDESIPLATRQKIRTAIAMWENKTCIRFSENGYNIDRIEFFDGGGCSSFVGKTGGTQGISISRGCDNIGIISHEIGHALGIFHEQARPDQSDHIFINYRNIPLSRWNNFQPMRKHQIDTHNLPYDTGSVMHYGPYGFASDPYIPTITTKNRFQQNTIGQREGPSFLDFEAINIAYGCNNHCPRTFCEHGGYTNPNDCNSCLCPNGFGGQRCETIQHLNCGSLIKIIIIICRPIRIILSPVWNEVKYITSPFYPEFSIQGQECAWLIESPFGTNVFFEFIDNFHIECHTTCDAAYVEIKNRADFRTTGYRFCCSKKPSEIFKSEANKMVLIYRSGRGNKGFKARIWSNAPPKTSKFAVDSCNCGEWSEWTTLCSQQCGGCGKRSRIRYCSRQDCRTEDKRTCNYDACPPGTNFLINNGEFHILWKGCCIGLFRFNTECSALADGENPFLAFLKSFLTSQNPKDKEITDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PP63</accession>
    <name>A0A3P7PP63_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PP63"/>
    <dbReference type="STRING" id="318479.A0A3P7PP63"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000384">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF399">
        <property type="entry name" value="BLOWN FUSE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="352"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="73263" checksum="64E1D358FE899AA5" modified="2019-02-13" version="1">MNEVSYIFAILSYTTLVKELPIFTVSLAFPSPKVYPKVHSFTFASLSEAFIHVIHLHRSFIEKSHNALCVNISNFLRKLKILETQVHYESLSNSLDDALMRKASICRTRPNEITDAKNALTAVGTCFAHTALDYVAQINIAHAHKDHLILDGLWSFIKECSSFFTRGHSFFDEWTAMESGPICETVAVLADKSKTIERKMQDRHALVPKEVFLHPAGISPDEDVIMEGYLFKRATNAFKTWHRRWFQIKDNKLIYSHRSVAMETPTVMEPDLKLCLVRSAPPSVDRASCFELITPSKFHLLQADSDALCNAWIRALQRTIHHLHEVDDNLDNFKPAISSVSDSSTLTNCFRDTLLTELWQIPGNEKCADCGAKAPKWASINLGALICIECCGIHRSFGVQVSKVRSLTMDSLEPEQRKLMLALGNRVVNSVYLAHLPESNIVPPPSKPTSSRPAREAWIKAKYIEKRFVRKSSERVRNFAHLRAEGCFLRARDDDGDGIRVLEAAKSGNITSLIRLIAEGVDINSTFANTTALHAVLKNGDCVMVEFLLLNGAKVNALDASLNTPLHLASSLGHTLIVCQLMKRGADQRLCNHAGETPLDVAVEKKHADIVTLLRLQQMRNEFRDEFNNPMDETVDDIMLDISRRKTKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PZT4</accession>
    <name>A0A3P7PZT4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS6556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PZT4"/>
    <dbReference type="STRING" id="318479.A0A3P7PZT4"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="62"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="264"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="596"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN56583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="734" mass="83444" checksum="67F3AB0BE9765533" modified="2019-02-13" version="1">MFDSAKERYDMHGQFRGLLQDDGSFFDDEVTLLGEEKKNELYFVLKSKFGFSHFRHRQKQAIVAALLGYDTFILMPTGAGKSLCYQLPAVISNGITVVISPLKSLIEDQKMKLRQLEINCCALTSDLSMTEVERVYGLLNESTPKISLLYVTPEKIAASERIMSIFLSLHRRGLLSRFVVDEAHCVSQWGHDFRPDYVKLNSLRKIFNNPFVPIMALTATATPKIVTDTCDHLSISNSKLFISSFVRENLKYDVMPKGPRSLFKLVDRMKALYPGKSGIVYCLSRKDCELVSKSLENQGLSTAVYHAGLADKKRLEVQTKWINNQIDVICATIAFGMGIDKPDVRFVIHFSIPKSLEGYYQETGRAGRDGLTSYCAILYSYNDSIRLRKMIEGENSTVGVRAMHLSNIMQIVAYCENVSMCRRKILVEHFGEVYDAEACKSGATPCDVCTQQIRNKNAFKMFDVTEEAKHIIQGLLKMQNVTLRYLAELYRGQMSQKKNSDMAVRFGHMHLSLYGRGTGMQEMDALRLMRKLVIDGFIEERLYNTKFDTTVAYVEPTMKGRDLVSNKTRTKVICLIFSSQFSFLYIFITRYMVKHADLFKECRAKLLTLINNIANNEGLNGQAILGLEGIEQIAALMPRTNSDLLQIDGMTNRKVERFGPQIMNLLKEFWMKLDVREENEIRRQLNYMKANDDKVGGFQIIPSQAITSTPSPISKNFGLFSFINCIFISTANSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q3R9</accession>
    <name>A0A3P7Q3R9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q3R9"/>
    <dbReference type="STRING" id="318479.A0A3P7Q3R9"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="366" mass="42326" checksum="CB7BEBB7FEAE8FED" modified="2019-02-13" version="1">MGREILLTLRYYARHVIPCFCIIGILGNCMALILIRTNYWLKRLTSNIYLCTLSLCSCLFLITVLFTWLDGTLEIPLYNGSEFGCRLLTFFAHMSDFNCVWMISWISCDRAIVLFRPGIRKKLCSKKFARNMVIVTISCACLLYSWCLFSAGLEEEEGSLYCGLSGNLSLMGYEFTDMHFYFTFLDTVICTIVPSVLISVVNSLSVYRYRQCMKIYSSGVLRVRFHRTIVDDTNHDETTNALRLLSQQSQTASIQSHLSTKSGKLRSSDLQLSRSLLIVTSTFVCLTVPNYVFRLYISIFNPTSVLFQLIYFATFLLYYLHHAVLFYMYIFWSPQMKKQLRPTALKLLECYCCKTVPDFGHSRIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q9Z1</accession>
    <name>A0A3P7Q9Z1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001240">
        <property type="protein sequence ID" value="VDN60753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q9Z1"/>
    <dbReference type="OrthoDB" id="5799199at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10102" checksum="EE0BFEE0E61E861F" modified="2019-02-13" version="1">MYFAGCTEDDLSDFFEDLRDDGGTGSNHSFVMYDKDSTLIAICLNSIDEIGAKDGQHFRRGLGTQLIELAIEEAVENDCAFIVSATTAVASQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QFV9</accession>
    <name>A0A3P7QFV9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QFV9"/>
    <dbReference type="STRING" id="318479.A0A3P7QFV9"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="297" mass="34753" checksum="53C66BB00FEB20B9" modified="2019-02-13" version="1">MVDFNFSKFKFNCSFSTVYKVKERTTEREFAIKVCIKQQILRERKIEQIYREKEALARLSKPENRHAFFLQIYCTFQDSDSLYIVTTLAKGGDLLRQLKKRIKFDTDITKFCASEIVVALGHMHRLKIIHRDLKPENILLSAIGHILISDFGSSKLQSQNRIVDFQQILRRRKCSFVGTAQYVSPEVLCGQLVQQACDYWALGVIIYQFLTGRHAFYEASEYIMYKKICHASYEMPADFSLETRHLIEQLIVVNPAERLGSVESGGVEHEFFKGIDWSNIEQCQSPFRIYLYFFINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SD84</accession>
    <name>A0A3P7SD84_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SD84"/>
    <dbReference type="STRING" id="318479.A0A3P7SD84"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="158" mass="18779" checksum="7C299300A3A35CF6" modified="2019-02-13" version="1">MRIGNEKMMCKICYSEEPLDVWLTPCKCTGSIKWVHKSCLNFWMTKAPFQQQVRCSLCRFGIFYKKLNWKLKELAEWSRPNINLNYMDIVHIIFDVTCTYRLIQGVLNVVKGRSSFARQLCNFFCWNTLVFTEIRKNFYLTIISSLMQSIFEISIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TBA6</accession>
    <name>A0A3P7TBA6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TBA6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017964669" evidence="2">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
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    </feature>
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        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
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            <begin position="563"/>
            <end position="580"/>
        </location>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="VDN59159.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="581" mass="65211" checksum="2F3182A3588454EF" modified="2019-02-13" version="1">MQVYNILLILLGLIAIGLSGSQFSDVAIRTYMTIDLRLLNWIYVLAGLLGFCSTLRGRFHVVTTTVYLVSFVIGVASAIFYGFTTYRVVHDFGTSGPILEPRRIDDPYHPGKITISAIMIAVAALAAFLALIAALMLNKLIIFMNPQWSLDNINGQNKYIKIATDHISAMLTVMSALVELSSTTTNRNSPFCYKVSLALSIIAAVWCLKTVDVDMNPFYFNDLILYRGLKNKLVVAISIDSLFFNFRFLTVIQLLISGLLMALVVLGLIDVRWNNSYNGGELLWVAVLVFCTGMLGVVNINSLPTAEFVLSVICLAVSVEKMCVSINDVYQSATYSKYLADSMDVYTARIVLYSVQLGVGYFLTDIYLPNFLLGIGKFVRIIGSTFFFSLGILFYGIVMIGSYVVYELGKWRFARVPLRNPYYRIANGTIAVAAFFILHAFQATMFPIYDFANTHLNTIIEVALILAASGALACVICIFCCALLYITSMEGYISNTMDIRENSVERGDKFQYNQIQPMQQMEEQSVYWSVVENPYYYNSSKRYYFQPYQINSGKSLQMATNKIKISYTFLINSCILLIIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TBX2</accession>
    <name>A0A3P7TBX2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TBX2"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="37" mass="4532" checksum="62C7189E1EC5E516" modified="2019-02-13" version="1">MIRKVSLKLMRIRFIAFIVLWYSIQSLILIFMVFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M0</accession>
    <name>A0A0N4U0M0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54492.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A0N4U0M0"/>
    <dbReference type="WBParaSite" id="DME_0000010501-mRNA-1">
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        <property type="gene ID" value="DME_0000010501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000010501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9963" checksum="64A063A58A60742A" modified="2015-12-09" version="1">MHVMNMHILMHCWYIEMAKERHGSVKTTIVNTQGIQEYISKITSKEELLKGCLKQKSEEDQADEMPWQSIVPSIDTSIDIYDNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N3</accession>
    <name>A0A0N4U0N3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4479</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N3"/>
    <dbReference type="STRING" id="318479.A0A0N4U0N3"/>
    <dbReference type="WBParaSite" id="DME_0000011901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011901-mRNA-1"/>
        <property type="gene ID" value="DME_0000011901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5816688at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.20">
        <property type="entry name" value="tRNA intron endonuclease, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28695" checksum="C7F20485C6304D80" modified="2015-12-09" version="1">MQVCSERRTGVSKNYRKPILLPNGEYSGILVGDYVIIREGRQSAELYEHGFFGNFLEERHYDVVQPACFTSADQEEDDIQQKMKLWRSIQLRNNNLHLSMEESMYLSHELSILKIFLKSRSISSHELWNYYFSRYGTRFIKRYVVYRYYRNKDWIVHSGLLYACDFIIYHDGPGYNHSTAALYIANPTNCHDIKLFSNFNRFLSNVKKIFIKIDVDIPSDLILNTPDCLKKICIKQVISSSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1E2</accession>
    <name>A0A0N4U1E2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4779</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1E2"/>
    <dbReference type="WBParaSite" id="DME_0000041901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000041901-mRNA-1"/>
        <property type="gene ID" value="DME_0000041901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000041901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11115" checksum="75138124DF9C7684" modified="2015-12-09" version="1">MEKETIDKFFLIFTAISAFIAFMLLILVLVKDKICPRKSIYVNGISDSGAYDNSTSKCLRNGLSLTIDMNDLEYIDDRSEHLIASSIIVNSLQHSLDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1I2</accession>
    <name>A0A0N4U1I2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4827</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1I2"/>
    <dbReference type="STRING" id="318479.A0A0N4U1I2"/>
    <dbReference type="WBParaSite" id="DME_0000046701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000046701-mRNA-1"/>
        <property type="gene ID" value="DME_0000046701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837168at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000046701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11147" checksum="21AE531F59E55DD9" modified="2015-12-09" version="1">FFKTFFYRNYRNSENSSNFSLFYFLYFWFRNFLVKKILQFDDVQSLVKRRNAELINGLIGMDLGKLSSVGKRSNAELINGLLGMNLNQLSSAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U222</accession>
    <name>A0A0N4U222_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS5055</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U222"/>
    <dbReference type="STRING" id="318479.A0A0N4U222"/>
    <dbReference type="WBParaSite" id="DME_0000069501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000069501-mRNA-1"/>
        <property type="gene ID" value="DME_0000069501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918422at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN55082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000069501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13516" checksum="A133CAD1DD3BEB41" modified="2015-12-09" version="1">MSGRGKGGKAKSSAKAKTRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKSRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNIHAVLLPKKVAGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U341</accession>
    <name>A0A0N4U341_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5493</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U341"/>
    <dbReference type="WBParaSite" id="DME_0000113301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000113301-mRNA-1"/>
        <property type="gene ID" value="DME_0000113301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813646at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231259" evidence="1">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000113301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16029" checksum="5CD24A6B1F2FD20C" modified="2015-12-09" version="1">MKFLIIFATIVVLVLCQFDDDIPPFLKGAPQSTIKEFETILQNGQSQTDQQLDANINAWIAKQTSAIQNAYRTFMAQIRTAQQQAEQARRTMLAKFSADARAADAQLTKIAEDPRLTGEQKQAKIEATFKGSKLSNYNSRKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U354</accession>
    <name>A0A0N4U354_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5507</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U354"/>
    <dbReference type="STRING" id="318479.A0A0N4U354"/>
    <dbReference type="WBParaSite" id="DME_0000114701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000114701-mRNA-1"/>
        <property type="gene ID" value="DME_0000114701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="266"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000114701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55818" checksum="2585369D4C729745" modified="2015-12-09" version="1">MKSNLVGAIDQGTSSSRFIIFDISLKKVVASHQEKISQFCPKSGWVEICPKQIYDSVMKCIEEACKKLSRTNYSVSQIRSVGLANQRETTIVWDSSCGEPLFNAIVWLDCRTAQLADEFIEKTPDKSKDFLKSKTGLPIHSYFSALKIRWLLDNVNEVQNSLQRGTLMFGTVDSWLLWKLTGKHITDVTNASRTLLMDLNKLDWSLELCKFFKIPRSILPKICSSAEFYSNILHGPLKGIPFTGCLGDQQAAMLGQNCIQYTDIKSTYGTGTFVLCNTGTNLIISKNGLLSSIGYQLGKNTSVTYVLEGSGSIGGNSVRFLRDNLAIINNLSEVENLANSVKDSGGVIFVPSFSGLFAPYWDSTARGTMFGLDQSTRKGHIVRAVLQAICCQTAELIDAFENDLGAKCVLGKLKIDGKVTSNVLFNQMLSDTIGRSIFCCPLAEATSWGAALASAIGANIISVDELNSFSFDKNAIKYDAKGNNEERMKLMFAWKEAIKRTQNWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3Q1</accession>
    <name>A0A0N4U3Q1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5721</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3Q1"/>
    <dbReference type="WBParaSite" id="DME_0000136101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000136101-mRNA-1"/>
        <property type="gene ID" value="DME_0000136101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855624at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042222" evidence="2">
        <location>
            <begin position="18"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000136101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49395" checksum="E916E0529800A6F2" modified="2015-12-09" version="1">MMESFLHLLIVIDLVFAQILLSNNLYTVSSQQNNYDNINGLHNTVDHVDSYALMLQPRNTYASNVPFRRNGSASVNIEIHLKEYVNERLRLPDGKTCVCPAGFTCNYLGSTAMARCYMSFMIIISSSDDSVQYASTGFLPLSSSGSVDFRALTTTQYNQWTQPYLFNLQSKPSAIDIFVHHMGMVIDTETGELTQMQTVVHVDTFIQSLTDVVPSVASMPQVIQTITLTGTILQTQLSLSFVVQCTGSLYGPNCDLNCNTSSLNSAIAICQSNKTGFFYTCSYATAPQVQNCVACIWGIVESSYCRDSNGKAIDPSVTLVSSEFKFTTIVLGISCAILFILLIAVTIYSCILVNRRNRQQQEDDAPGHNYRSSIRVEANSNQTLLQSACPVRLNSNLIPPYDHPQAPLISSRNFPRSAPLTHLGGDSSLNDTLNSTISSIQLPSREADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U426</accession>
    <name>A0A0N4U426_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5872</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U426"/>
    <dbReference type="STRING" id="318479.A0A0N4U426"/>
    <dbReference type="WBParaSite" id="DME_0000151201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000151201-mRNA-1"/>
        <property type="gene ID" value="DME_0000151201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000151201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36203" checksum="01C28C5DA5F1AF62" modified="2015-12-09" version="1">MLRRVLEHRFKYLQPTVTCFIDFTAAFDSIDRAALWRMMERNSVPTKIIRLIKAFYEHTSVQICIYGELTDSFEIRTCVHQGCALSLNIQLCDRLDNGHCLSARSSPGHRITDLEYADAVVLFVDSYNEMQVIVNNVSETAARIGLWINVNKTKVFSSYVQEADKMPLFVNSLPVEEVSDFKYFGSTLIPNGQAKDDIITRITWIKSQDPIHLRSNTTCISNVITERRLRWLGHILRRPPQEFTHISLFAKSCDGWRQKRGGPIKTWTDTLKKDFECIGGPAIYGLRRWKKEWLPLLLTMASDRAAWKRLTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4D7</accession>
    <name>A0A0N4U4D7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX9C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6001</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4D7"/>
    <dbReference type="WBParaSite" id="DME_0000164101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000164101-mRNA-1"/>
        <property type="gene ID" value="DME_0000164101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846776at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000164101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15476" checksum="11025586CD01540E" modified="2015-12-09" version="1">EICEQLIECTTKARLKVNECIASHDSPLKAVSKCHNETLHKQLKRLIEERDNYYEGCLRKKMPEAAAIDNAKKRAKCQKIVQKNPFKQNIQKSRRSMQRDRNINQQKQCYKDVKKMRIHCSLLAKCCSISKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4J5</accession>
    <name>A0A0N4U4J5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COMM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6069</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4J5"/>
    <dbReference type="WBParaSite" id="DME_0000170901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000170901-mRNA-1"/>
        <property type="gene ID" value="DME_0000170901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070972at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000170901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13010" checksum="DB43949CD807EF18" modified="2015-12-09" version="1">MNLSNTQIASTSCSTSKNSNSDNDGNKKADLSSLESVVFSSLSGYQAIPVRVKILLHRALANLSEHNVESILNRAGWTKENFERGFMIERSTMLLTLATFCKDLLRYFYDALQTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4V2</accession>
    <name>A0A0N4U4V2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6198</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4V2"/>
    <dbReference type="WBParaSite" id="DME_0000183801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000183801-mRNA-1"/>
        <property type="gene ID" value="DME_0000183801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805119at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039135" evidence="1">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000183801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36123" checksum="1F3658AB10853B78" modified="2015-12-09" version="1">MKQAKFYLILFDLIYSISCSSWCIDEPAYNRLVKYYYDEKSNMCLAFRSDCLQSKLILYDTLKECSTSRMPHHAKKITLSCAQNQYILSSSNDNIPIPYVFSSIYCQNDGKSEFCSHIDGEYCHSFKPYAYCCVDNINGETKYAGFKKFCGHSVLEQESEFPKPAPVNCNLDGKRTGIEWYANTNKSDYPTCFARRDHCRTPGTKRIKNIQTYRTAQDCMNKEFRRANHSVKYVLRCSKGYGIVKYKGEPIIARGDECRGIYDSDLCDRNELCFGNTNFKYCCNRKSEENEVTHKFTGKNFMASMTNNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U517</accession>
    <name>A0A0N4U517_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6278</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U517"/>
    <dbReference type="WBParaSite" id="DME_0000191801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000191801-mRNA-1"/>
        <property type="gene ID" value="DME_0000191801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877188at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000191801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18693" checksum="95E8D99E83536D3C" modified="2016-06-08" version="2">MSDSSLLRRISQNYSDTAAISQLYVNCCNGNSATFSASKSCETSSSPRRKLLKSWRNTKRHFSLAGILNRTIHYGGSPRRSMPCNGANEYEHFWPSSLSEKIVYGNSSLSSAEQTKRVTVIDRPGQEKAHYTGNKSRYRAESPSKQLVSLLKLPVLQQFNSNFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U551</accession>
    <name>A0A0N4U551_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS6315</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U551"/>
    <dbReference type="STRING" id="318479.A0A0N4U551"/>
    <dbReference type="WBParaSite" id="DME_0000195501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000195501-mRNA-1"/>
        <property type="gene ID" value="DME_0000195501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917019at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN56342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000195501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21461" checksum="3A80003C05F02014" modified="2015-12-09" version="1">MLRILPSVNCRTTYIVNCLSYSSDAAHKNSGDEQIERQAVDYRPGSDSYAYENPWPKLNRGRLDWLFGDGWRRPLAKDQGAKMRREWIWFNRVAHDEYEDWKRYHSFMFILGTVMLVWATSWVVFAKPDWPHAGEWAYREAHLEILRREKADLPYISKDLIPPSRIILPSEEELGNFEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P8</accession>
    <name>A0A0N4U5P8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6546</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P8"/>
    <dbReference type="WBParaSite" id="DME_0000218601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000218601-mRNA-1"/>
        <property type="gene ID" value="DME_0000218601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159259at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12417">
        <property type="entry name" value="RRM_SAFB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000218601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38878" checksum="7D1B4056CFBF3891" modified="2015-12-09" version="1">MNTSSAKFVTINELRVFELKQELEKRGLDKSGIKLALVERLEAEIVDDKSIETKLLVDVKKSEEKEVETDEKIMKNRSNEKNSSNVASTANVQTVESTPVDTSTVAHPQCSARKEKFAENSLWIKGISPTTKAADLKVVLAIFSKFGRVITAKIFTRRQQPSSTCFGFVTMIDAAAADLCVQKLHKTTVNGRIIVVERVCFFSLFFDDFGVADRSTMPVVKSISKKNTLTSVPVAAKESATDSETANVKKTSTGEQKTLTEKPVKKEKESLYKENEKRISSNSVIEKEKSAAGSGRSSLKRDSETVLKKTPVKGPVTNGIYCEIFYSYFLYSNGNAIFIFAVNSGREPFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5S7</accession>
    <name>A0A0N4U5S7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6582</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5S7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5S7"/>
    <dbReference type="WBParaSite" id="DME_0000222201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000222201-mRNA-1"/>
        <property type="gene ID" value="DME_0000222201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000222201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15794" checksum="ECD0C6ADEA7A1EDA" modified="2015-12-09" version="1">MGKIMKNGKVVLVLSGRFAGRKALIVKAYDDGSADRTYSHALIAGIDKYPKPVTRMMGKKKIKNRSKLRPFLAVASYSHLLPTRYSVDINLDKNIVNKEVLKEPSRKRKARMEIKQKFEERYKTGKNKWFFTKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U639</accession>
    <name>A0A0N4U639_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6722</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U639"/>
    <dbReference type="WBParaSite" id="DME_0000236201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000236201-mRNA-1"/>
        <property type="gene ID" value="DME_0000236201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000236201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11013" checksum="C9C8C0F6DCB1A7BE" modified="2015-12-09" version="1">MHYEEANLSETGKFVHFRSDAIHDDVARNSSKLLERINPHSFGLINEKRPLVLMLYIFIISALIIAAVLSTIHVYITERRFWKEKKLLKAMFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U673</accession>
    <name>A0A0N4U673_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6761</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates sugar transport across membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U673"/>
    <dbReference type="STRING" id="318479.A0A0N4U673"/>
    <dbReference type="WBParaSite" id="DME_0000240101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000240101-mRNA-1"/>
        <property type="gene ID" value="DME_0000240101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF233">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000240101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27759" checksum="7350A98CDAC6A32F" modified="2015-12-09" version="1">MPVNVDEITAAELLQLFFDFYTDNLIWSLFLTSTAVHAVVLIASPLQAVFKWYRRRSSDSDTPLPYICAAIGSGLWLRYSIFIEDTKLILLQTYAVIMQIFFLLTLLFYRSKKQQLVKALLYILLLQMALYLYIEKLTVDDGRVMTGRFASAAQIAGSFVCPFMIYRAVKTKVIDFIPSALVIFTCIMELHAIVYSFAIDDFYMLIANTTFCIMDGSLLCMFFIYPTERKNYRKIQEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U681</accession>
    <name>A0A0N4U681_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-AMP-activated protein kinase subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6771</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U681"/>
    <dbReference type="STRING" id="318479.A0A0N4U681"/>
    <dbReference type="WBParaSite" id="DME_0000241101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000241101-mRNA-1"/>
        <property type="gene ID" value="DME_0000241101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000139">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="9">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000241101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="70795" checksum="D1EE6F9E19EE0C75" modified="2016-06-08" version="2">MIVEIFEWNEWLADDARDSCQKNVRNDILESANDWLGKAMGNNQGGLHKRERTDSQRNRVWSSNTSNTMGTANAAEDGCPVQVKIAKSDGTSSTPSIQFTESNEYPVVFKWQGGSQTKMVYISGSWDNWKRKIPLCKSTQDFSTIINLTPGKHEYKYLVDGKWTLDDNVDKVDNEFGSQNNVILIDEADFEVFDALDRDLASSNAGEAMRKMNVAGTHQHDTPNDRELEKLKQFTQEIPDRREFERAQNPPVLPPHLLQVILNKDTPVQCDPNVLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPIIRNVKNLLALNESNFKNIEIKVADNLGIWFMRRLWTAERSWHNVSVSSKWSGSLSEYAFSIDIECTRKKDVDVWTLGIAPEETCSYSLLVDICLTVNDTRFLPNIILQEETPCCANYFVTFQLLVIQTLSPQQLEAETPYRNFEIICEDCSVFVDTLYLSSLGGRLFTEWHEMNSKGKSSVELTDLASTELMCLIDATAKFRQIVITRSNYDLLASISFRYGIASVLRAIETYLIDAEKVNPIRKMEFAVSYKLARLGDVVSRNLISSGTAMEQLHDYLAANGNTLEQAHPDVLASLNIYPDYVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6A2</accession>
    <name>A0A0N4U6A2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6798</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6A2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6A2"/>
    <dbReference type="WBParaSite" id="DME_0000243801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243801-mRNA-1"/>
        <property type="gene ID" value="DME_0000243801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16777" checksum="EF0F2FF89B806FDE" modified="2015-12-09" version="1">MNDCDELDLEDLFSGRIDKRELEFYAKEYENQVMGERQSDAVLFRYCIALTKSNKENIRKGIELLEKFLNISTEYSKERIIIQLVIAHTRLKEYDRALAYLNVVKQAQSNAACATEMENIIKNRMRNADSVGCKGKALPNRSDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7A1</accession>
    <name>A0A0N4U7A1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 DOCK-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS85</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7A1"/>
    <dbReference type="STRING" id="318479.A0A0N4U7A1"/>
    <dbReference type="WBParaSite" id="DME_0000285601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000285601-mRNA-1"/>
        <property type="gene ID" value="DME_0000285601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162143at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="2">
        <location>
            <begin position="259"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000285601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56302" checksum="30D29A9DC167BC77" modified="2015-12-09" version="1">MDQLIAIYYFRSPNNNNKMSTVRGKLYCTALWANSVSVKKQKDNIIFHFFQGKEEKKNNFELIPSSLKLCDDDCIESDVSLKSRFLNNSKILKRCSYNKRIQTIEDIIREEPLPTFFNAFGTFLFRQNKTSRKLKPVKPNVEYHIMVNIQSAINLAERIEGGLKPFVIARFQFVKLKDKICCFKVVSKLDSDNREPNSIHEQVEYCWMGFVRIPFSTIYGNGKKIKGSAQYLSYYVYICIHTYIYIYIYITKIFAVFSGERSAFVLIELSKVMLLLNPSDGNTYYVNDAFCPLKQVGCAINNCNIYGNIQPYDHPSQMSFNFKSINHWKAIFETDVNDIESVQPSLITYTKTNAESVMELRSTLEREIRLKFDESRPYGIPHWNVLISRMLRELLNELDSMNPINDINCIENRLSELRRAYKINLTIFRQSYTNVDSIIEHVLHTNLHMNSDQRLQFAFALHINAFVCNILSVSIAIASLSPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U811</accession>
    <name>A0A0N4U811_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7314</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U811"/>
    <dbReference type="WBParaSite" id="DME_0000315501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000315501-mRNA-1"/>
        <property type="gene ID" value="DME_0000315501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000315501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35098" checksum="8DA036F18139D241" modified="2015-12-09" version="1">MSDWTLLIVNVASTLTIILTSIVVLVNCAGNEEQSRRSSGKAKNGSINGTRIPLSRNIVGNNLNGHTELLSAQHENTQPFRVELIETRRIGTECRDKALLAMDKHTTRIPIAKNVEQTKGPSKIGPCKECNKFAVSNVNETKMQVAENEKAIKTKKPPRQFFYQKTVIVPREGIELHQRISPVNINTSQIQSNGSPNDESHVAISSNHMQEHATPAKNPFKADLEVFYRANAPQTFNLSMNTDFSEKILPYNHPTRTSLAQSFNGNRNYENDQTFRPILHSSNRIRYKLKEPVSLMVYKYESLIAQIRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8A7</accession>
    <name>A0A0N4U8A7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fam20C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7425</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8A7"/>
    <dbReference type="STRING" id="318479.A0A0N4U8A7"/>
    <dbReference type="WBParaSite" id="DME_0000326601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000326601-mRNA-1"/>
        <property type="gene ID" value="DME_0000326601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="9">
        <location>
            <begin position="279"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000326601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47777" checksum="66817C7DFEA02BC4" modified="2015-12-09" version="1">MRKHPRHRNLLKDDQPLEILEYENANIDFSGIADSGQYYDSNLIERLASYASELNMNELITKECEFNETLKDFWKQTQGKIVSEKDSWEKFYARIGSCDLYRDVEVIDRLLNDLHTLQVNNVAIMGGGTQVKLVITFENDEQAVFKPMRFGRDYETDPNHFYFSDFERHNAEIATFHLDRVIGFRRAVPTVGRVFNMTSELMEKAEKVLQKTFFISPAKNLCFVSKCDYYCDTNHAICGKPDLKEGSVQVFLPDDRGVPRKNNKSPYRRQNFQKFLILFYNNLDRHHYETFTVFDGKPVYPIHLDNGRAFGRTDIDHDDILYPLQQCCLIRPSTLRTLMNFYRGPQSLSQALHKSMSADPVKPILATKHYSALERRLYKIMLAIDKCVKQQKNGIKDVVMAEYHSDVNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8D8</accession>
    <name>A0A0N4U8D8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7463</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8D8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8D8"/>
    <dbReference type="WBParaSite" id="DME_0000330401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000330401-mRNA-1"/>
        <property type="gene ID" value="DME_0000330401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000038">
        <property type="entry name" value="BMA-HSP-25, isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="116"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000330401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="25342" checksum="B7A1CA31E71D13B2" modified="2015-12-09" version="1">MNRERNIDVSRSNYSVIDKEFGNIRERFENEMKRVEEEMQRLRREFEGYTPSRTTAPPPPPSSDNRQTSYHREESRRYESSTQGNLPSHMAVDRDRFFQDSEMNRTMMSTRPIYDPYLENLKSPLIKDESDGKTLRLRFDVAQYKPEEVTVKTIDNRLLVHAKHEEKTPQRTVFREYNQEFLLPRGTNPELISSTLSTDGVLTVEAPLPQLAIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8J6</accession>
    <name>A0A0N4U8J6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4708 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS239</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8J6"/>
    <dbReference type="STRING" id="318479.A0A0N4U8J6"/>
    <dbReference type="WBParaSite" id="DME_0000337301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000337301-mRNA-1"/>
        <property type="gene ID" value="DME_0000337301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000337301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33014" checksum="5CF838F1566115B4" modified="2015-12-09" version="1">MRIIEKNKNVTTENENLSVAVVNESLLSQENVLSERRFIGSESLKKPGGAGKLKQQRDLKCKINKEKISYGKETKTLELRYTAGGLNNIEIDLGSCICIHGHLQFVDCIMQSLLYQRAFIPALIPQILDGKTQQEMKFSETYHKVRKTLNKLFCCENRRLIKEVIVVVGASCHLPSEVYYIPVCVCDSLGQLQKICLKVMMGSNMYCVQENMSNKRAYVILRASKTLRCLEDVEEESGFEPPSLNLIKKRNIFSFKFEIKHHCNEEFDSKPQNYSWFRLSSVLRGFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8U5</accession>
    <name>A0A0N4U8U5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS348</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8U5"/>
    <dbReference type="WBParaSite" id="DME_0000348201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000348201-mRNA-1"/>
        <property type="gene ID" value="DME_0000348201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231598" evidence="1">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000348201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="15343" checksum="F379A5F2DCD46D81" modified="2015-12-09" version="1">MKRLFVLIALAIPAQACIGGGGCCPQPPCGGQMQCCCLSLPTLPPPPPICLPSLKLPSCCCPTGGGGGCPPAAPPCGGGGGGCGGCSGVGAAAGHFPPPPAPPGGYAVAPLSYGGAGAYAAPAPSYKGGGGAYGVAGSGGTYGAIGGAGAYRAGDGVYGAGGGGGSKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8V2</accession>
    <name>A0A0N4U8V2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable RNA-binding protein EIF1AD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 1A domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7495</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8V2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8V2"/>
    <dbReference type="WBParaSite" id="DME_0000349001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000349001-mRNA-1"/>
        <property type="gene ID" value="DME_0000349001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="6">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000349001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20072" checksum="75C69A4ED451A50A" modified="2015-12-09" version="1">MSNVRKRRIVQREAKTIMVLPKKDDIIAKITASRGNNLHSVDSCGESYLVSMPTKFRKSIWVKRGNFVVISTIQEGNKVKGEIVHILDNENILYIYEQNLWPQRFLEDAEKLTRAFRRNVPVSSNKKHEMIDADMLPPSDSEVESEGEEYECDDESEEEIITYNPNLSDIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U900</accession>
    <name>A0A0N4U900_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein unc-98</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Uncoordinated protein 98</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS7546</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U900"/>
    <dbReference type="STRING" id="318479.A0A0N4U900"/>
    <dbReference type="WBParaSite" id="DME_0000354101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000354101-mRNA-1"/>
        <property type="gene ID" value="DME_0000354101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002530">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN57573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000354101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24393" checksum="433A797A86A80DCE" modified="2015-12-09" version="1">MADETSAELSSRSTVVERIKDDNGFIFYKCRFCGLTYNYLTTLRAHERVHNVEMPYKCNRCSEAFHFMCELEYHAKQHSNLKGYKCECGRIFHTYTDLLYHRHPDDNETVLVEVEQNITKLKCKTIPETEFPIPEFIEKGFEPKHPLKVYSDVRSKPYICQYCSKSYSDSRSLAYHMYGHRGERMFNPRASRYLMARSDTSYISPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9J7</accession>
    <name>A0A0N4U9J7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7772</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9J7"/>
    <dbReference type="STRING" id="318479.A0A0N4U9J7"/>
    <dbReference type="WBParaSite" id="DME_0000376701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000376701-mRNA-1"/>
        <property type="gene ID" value="DME_0000376701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000376701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26454" checksum="4C848993F0B094EC" modified="2015-12-09" version="1">MNFNDKAKDWRLKTWRLRMCSGEEEKDYDLRLIEMNSTIFGNLFNAKMQNVDEYKPYSLMQKILAEFIAVTILTFVGATHQLTKTALLNTSLAIGCTIFVLACSFGRISGALFNPAVTSCVMFCGKIQPLCAFALISAQLFGSICGALIFKSLCTIAEYKGIFDNVPNGFTWWQHLIAEICVTFILCQTVMLTAVDIQNFVMAPLAIGLAHTLNILATTNSNPQFKQISKRNMSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9J9</accession>
    <name>A0A0N4U9J9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRUD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7775</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9J9"/>
    <dbReference type="STRING" id="318479.A0A0N4U9J9"/>
    <dbReference type="WBParaSite" id="DME_0000377001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000377001-mRNA-1"/>
        <property type="gene ID" value="DME_0000377001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF31">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="277"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000377001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65355" checksum="4283E33620EACB8F" modified="2015-12-09" version="1">MERDFYITEFVNDNCTEMKCVLKHLYSDFIVNEISSDGTIVIDSSLISTSPSDLMDNNVVNNRNSLSSPQPQQPQFISTECFTEIKGLLNDKSKKAEIDVKVKNRKGNFLQNLTKEERTNIHDWIRKSFNDKLSSRTDLGKITVSHKKDNRKRKYWPLDRPDYLHFTLSKENKDSHYALSLLAKFLRVKIANFGICGTKDRRAITHQKVSIYRVEANRLHDLNMRLRGIKLTNFFYHTRPCRIGELYGNRFSIILRNISEISEEEIKQRIKAFIENGFINYYGNQRFGNFQNTADVGLAILHRKWEEAVRMILKERSASGCLSESLKIWNETNNASLALKKLQGSMSFASIEGQLLNHMSQPNWSYKEALMKLPRSTRSMYIHAYQSLLWNKIFAHEKNYIVKYCSVVQIASKRVRQLGRQLIKGDIDINGNEANDIFSVALPIISSSAVLPKNVVAEWYNDLLNDGAFSLEDFSYLERNFAIGDASRRLFAKPKDVEYQLILYSDRNAKLQPDLGGLIDSEKIGSGPFKALKIIFSLPAGSYATIALRELTRCNMDKLSQNLSSTIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9K9</accession>
    <name>A0A0N4U9K9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7786</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9K9"/>
    <dbReference type="WBParaSite" id="DME_0000378101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378101-mRNA-1"/>
        <property type="gene ID" value="DME_0000378101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5567844at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7865" checksum="B67B73422629ABAC" modified="2015-12-09" version="1">MVECYRLASWSNAVFISLDLEIMTNNIPLEGRIRLPNRINDCIHDCSFISSNIVNSHRGNDDSRDEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAM0</accession>
    <name>A0A0N4UAM0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8090</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAM0"/>
    <dbReference type="STRING" id="318479.A0A0N4UAM0"/>
    <dbReference type="WBParaSite" id="DME_0000420701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000420701-mRNA-1"/>
        <property type="gene ID" value="DME_0000420701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872565at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF385">
        <property type="entry name" value="CUTICLE COLLAGEN BLI-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000420701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="30648" checksum="5F30D97587EFEE78" modified="2016-06-08" version="2">MEKKSSLRSVAFTAVVFSTVAVTACIFTFPMVFHYVQTLQATVQNIAAEELSNSAIDNVMTYRKLQGEVEYCKTRSRDMWREMVDMAPEGEDSLDVLMRVTRQAEAQCCTCQQGPPGPDGPPGIPGKDGAPGDGPGAPGPPGRDAEIHEKILPVPPQCPCQAPAGPPGPPGPPGSDGQPGNPGPNGEDGAPGPQGPPGPPGPPGQPGQPGQRGPPGEPGQLVPGERPPPGPPGPQGRPGPPGQPGRPGTPGKDGDNGPPGNQGEPGPRGPPGPNGQAGEPGQPGQPGAPGSCDHCPPARLAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAQ7</accession>
    <name>A0A0N4UAQ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8131</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAQ7"/>
    <dbReference type="WBParaSite" id="DME_0000424801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000424801-mRNA-1"/>
        <property type="gene ID" value="DME_0000424801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000424801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14718" checksum="0C9C9630953DF56F" modified="2015-12-09" version="1">MVYTRRGLSLARIILVNCKGETVLDIIVKPESPVMDYNTRFSGLTKNLVDATIYDFKQARERFLEFVNSETILIGHSLASDLKALRIVHHKIVDTSDVFPHERGPPYKRSLKNIFSDIFHMKIQEKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBP1</accession>
    <name>A0A0N4UBP1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8516</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBP1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBP1"/>
    <dbReference type="WBParaSite" id="DME_0000463301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000463301-mRNA-1"/>
        <property type="gene ID" value="DME_0000463301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000463301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="17001" checksum="222775785E6EE05D" modified="2015-12-09" version="1">MENEECETNMVDGSGFYEAESILQKRIYGRQVYYLVKWSNYPIEEATWEPITNLGNCKRLIKDYEQRKSEHYKDILKENASTNPQSYCEVERIVCMDSSEENTKPSYEIEYKDGRRRWVDYEIAHKYLKDQLITYYESMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBY2</accession>
    <name>A0A0N4UBY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8624</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBY2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBY2"/>
    <dbReference type="WBParaSite" id="DME_0000474101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000474101-mRNA-1"/>
        <property type="gene ID" value="DME_0000474101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973987at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000474101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16451" checksum="B9FE28B990D39DB4" modified="2015-12-09" version="1">MAFCRTTVIDRLLNYGDYPPNSSTLTSRLWNDIESFERDNLAEVYRKLANIEEEIWGKIIIMERNSRIVKAYLRSRIITIDGSDWDFDGSRYIVQNFIGFPLLLLCQIPQYLTHSLAVAVTHLSSGSPGSPTFRKDLFNQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC21</accession>
    <name>A0A0N4UC21_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pantothenate kinase</fullName>
            <ecNumber evidence="4">2.7.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8673</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC21"/>
    <dbReference type="STRING" id="318479.A0A0N4UC21"/>
    <dbReference type="WBParaSite" id="DME_0000479001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000479001-mRNA-1"/>
        <property type="gene ID" value="DME_0000479001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24122">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF30">
        <property type="entry name" value="FUMBLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000479001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="48912" checksum="106EA8754B932026" modified="2015-12-09" version="1">MDGSGDMKFTICEDETTATTAKSRQRLLSLSVPPSPWFGLDIGGTLAKLVYFEPQDDELFDETDEEFIRNKRIQRYLFSKKAYANSGFRDEQLQLKDVEINSRIGTLHFIRFPTDRMVDFIGLVKDKGFARLISTICATGGGAVKYAEHAEKILGMQFHKADELDSLIKGIEFIAANNPNECYYYENPLNDQTCKKVIWRWSSGRSSTSNLLNDEKKDGLQYPYIVCNIGSGVSVLTVRGHNNFERITGSSIGGGFFQGLCAIMCGCDSFEESIELASHGDNKNVDKLVRDIYGSDYAQVGLSGDVVAASFGKIGSSKNRDKVARADLARSALVTTANNIGSIAFYAAKSCNIDRIVFVGNFLRVNPIAARLLSYAMTFWSKGTKKAIFLMHEVRFHFVNSVLQALGYLGAVGCLHKLVDVTNMRRQVRAMNGDLTLKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC82</accession>
    <name>A0A0N4UC82_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS486</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC82"/>
    <dbReference type="STRING" id="318479.A0A0N4UC82"/>
    <dbReference type="WBParaSite" id="DME_0000486501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000486501-mRNA-1"/>
        <property type="gene ID" value="DME_0000486501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000486501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15595" checksum="98F732A43B62EE59" modified="2015-12-09" version="1">FPISFTNSFSLSGITCKIFHKKISSRKPNSRRERTTYNQHQLRILERFFIESHYPDMYAREHIAQQIGLPEARVQVWFKNRRAKERNKGPKVQNKTNDAKITPTPPPQEPLRYATAIMIPGSQEFNERPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCC7</accession>
    <name>A0A0N4UCC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extensin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS536</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCC7"/>
    <dbReference type="WBParaSite" id="DME_0000491501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000491501-mRNA-1"/>
        <property type="gene ID" value="DME_0000491501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042812" evidence="2">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000491501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30441" checksum="F832F5EB2DB573D8" modified="2015-12-09" version="1">MLNFVFVKAAILYNLYSLFLYKCDAASYERGPFMPPERDQFGGGYHRPSNVHQKPVSPPGPFHPPQKTPQIYPPVDHIPPQKPPQIYPPFDHIPPQKPPQIYPPFNHIPPQKPPQIYPPFDHIPPQKPPQIYPPFDHIPPQKPPMYPKISGSFPPKSQMPLTQQQSYISRPVVQQPHAHVSEEEDYYQPTTDTEKPLTYVPPANVPRKSQSYDRPSSQSYSSEGSYSSQGSYSSGIGNSDFGTPEEPLRRRPRFAALSLYDQGFFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCI8</accession>
    <name>A0A0N4UCI8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8783</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCI8"/>
    <dbReference type="WBParaSite" id="DME_0000498401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000498401-mRNA-1"/>
        <property type="gene ID" value="DME_0000498401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000498401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11359" checksum="2C1E9057080C80C6" modified="2015-12-09" version="1">MSQPDVPTCPSSHCSACPSWHYFPTCPSSHYSARPSRRDIPTCPSLSQLAFLLITQQFAFLCTFCHVPSIIIVFEQVYSYHWDAISFKQCLLQHFGVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD71</accession>
    <name>A0A0N4UD71_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9059</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD71"/>
    <dbReference type="WBParaSite" id="DME_0000526001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000526001-mRNA-1"/>
        <property type="gene ID" value="DME_0000526001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000526001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10681" checksum="64790BF68A17C1CF" modified="2015-12-09" version="1">MATGLDDIVLRIEMTGRLGDNRKFRLHKTTITRISEMVRDSNGMPVKSGRNSLMTNLTVMRHQLPRNIADTFVEPYVCTWEPPTEESFPYPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDK1</accession>
    <name>A0A0N4UDK1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Syntaxin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDK1"/>
    <dbReference type="WBParaSite" id="DME_0000541601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000541601-mRNA-1"/>
        <property type="gene ID" value="DME_0000541601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000541601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11545" checksum="233F1A1DBC4F3370" modified="2015-12-09" version="1">MSAYVSVRMLCVCASVCVLCSYMSAPLHVCLLVDVCASVCVSVRVCLRLCVCVCLVMSVPLHVYSVHAFICVSVRACLCLCMHVCQSVRICVHMSMCMCVHVCLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDT6</accession>
    <name>A0A0N4UDT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS617</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDT6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDT6"/>
    <dbReference type="WBParaSite" id="DME_0000551101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000551101-mRNA-1"/>
        <property type="gene ID" value="DME_0000551101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF4">
        <property type="entry name" value="BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="3"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000551101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43418" checksum="E5A6E15760D5A64B" modified="2015-12-09" version="1">MVKNFKNRWEVQGAAIAVYHKDELVVDLQGGYADASSLRKWADNTRTIVFSTSKAIGALCIALLVDKGLVKYSDLVSKYWPEFAQNGKESITIDWIMSHRAALAAFDEKITQEDACNYERMADIIAKQQPNWTPGKKCGYHALTFGWLVDQLIRRIDPKHRSVARFFREEIAIPFDASDIDFFIGLPPEEEHTVSRISVAPCWYTIREMIYDPRILILFTVLFLGLPGSLMRKMWNNCKWFKISKKTNTVNDPELHRMEQIAILGITKAKDLAKMFMLFAQGKLISKKLLQSFEKPQIFGTPDKVVWLPLAIGHGFSYEKHPYEKGRWLFGHPGYGGSTVMVDLQNELVVAYVTNGLKTGMGELTRTYRLLRNAALRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE19</accession>
    <name>A0A0N4UE19_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS644</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE19"/>
    <dbReference type="WBParaSite" id="DME_0000559901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000559901-mRNA-1"/>
        <property type="gene ID" value="DME_0000559901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000559901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15069" checksum="975AC695536E3BA3" modified="2015-12-09" version="1">MPCHRRFAFARRARASRSRSSLASMRSSRGQARKQPRRLRSRSSNRSRSLSLFAQTRPRDSQGRFLPLDFVDTKDYGHIAQKSTKRSAGRSGKAFHERSVSPRRQQIIRLSSPTQLRIIIRLSCLQNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE48</accession>
    <name>A0A0N4UE48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS677</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE48"/>
    <dbReference type="STRING" id="318479.A0A0N4UE48"/>
    <dbReference type="WBParaSite" id="DME_0000563201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000563201-mRNA-1"/>
        <property type="gene ID" value="DME_0000563201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10503193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000563201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19808" checksum="9FAF5CA9AE9FD8BE" modified="2015-12-09" version="1">MENGKFFDRPINLLYPLKINGEESGEVQTTTKDKLEEPIARRTRGDRENESLFNQWISDIPFNLPQKWNCNDQFTANFTLNEIAVYTKTHIRMPALKCNNITRTVCTKVFLRLSLSVESHQTTTSATTSYFWKAFVRQTSSSTNGIDLKQISPNQWRTAKSFTFKNNETIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE68</accession>
    <name>A0A0N4UE68_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS701</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE68"/>
    <dbReference type="STRING" id="318479.A0A0N4UE68"/>
    <dbReference type="WBParaSite" id="DME_0000565601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000565601-mRNA-1"/>
        <property type="gene ID" value="DME_0000565601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000565601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31093" checksum="23A30ECD7E4B965D" modified="2015-12-09" version="1">MDLLKVAMIGSGNWGTTVARIVASNIEIYKEEFDPIVKMWMFEEIVNGRKLSEIINTEHENVKYLPDILIFVTPHQFLVNICNNMKGKLKENAIGISLIKGLLPEKKGGIRLISEEIHDILNISVSILMGANLAQEVADGHFCEATLGCLESNEISEKLRKLFETDNFKISVVHDPKTVEVCGALKNIVGCAAGIADGLDCGQNTKAAILRIGLVEITKFVDMFYPGSHIRTFFESCGIGDLIATCYGGRNRAVCEAMVKTKKVFTTKNFSDQIFYFLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UED4</accession>
    <name>A0A0N4UED4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9328</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UED4"/>
    <dbReference type="STRING" id="318479.A0A0N4UED4"/>
    <dbReference type="WBParaSite" id="DME_0000573501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000573501-mRNA-1"/>
        <property type="gene ID" value="DME_0000573501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF53">
        <property type="entry name" value="VON WILLEBRAND FACTOR TYPE A DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040990" evidence="8">
        <location>
            <begin position="20"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="39"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="267"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000573501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="774" mass="86808" checksum="C5BAEFB592BA39E4" modified="2016-06-08" version="2">MLLTELIILSSILFSTVNTIDYEDNDLAKVCRPLDRQLDLLFILDGSGSVSGSTFDTQMAMLNKIVDMVEIGPEKTQIAVMQYSSYTRIEFGFNVYRMMALYHLPPFTFLIFYFKAHLDEFINENILKDEVELRTAIQKIRHISGTTKTGKALDKALQVFKHNEIYGSRVNQEDVAQVAVVVTDGHSHDDPVPAAVRLRQAGVQILALGIGAHINMGELLDITGDENLAFQNLNSQLSLDKFANQFKKIAVGEHCDFSRGPHGAEITCKSDSIEIGVSTVNPFYGHMYVVGQFNRPECVVNARNSSREIRLTIGLNSCNIQKQFMLNPKGIMFETGLILKFHPWYNTKKDKLFSVQCFYPEKSPKLPKKFLRNHIAISDSQPMKMPCNYKITTRTTEQCKLEDARVGDEIIHLWECAREVLDTYQSMLVHSCILTDINSALNRTIIDKNGCVVDTSVIDQPDYQEPLMVSAVGRAVKFPGSTLVQLKCHLRFCDRLLGECDGILPPKCRRTREATIEDVITKQDVFPIDMNSFSNNDEDDDYADSDFGYTTTVSPLVTFGSSKVEKKLPPRRRLSIDQRVSASASREFTQKPTSGKLDALPIIPTKITTSEDTLSHIRPIVTNGRTSNGQPRVINFPVGGIDFQLNTQDVAIVNNEGLKKHFQKTMEVYSEEQKKSNENKEIAATEATTKQTIKNTLKEIATTALSPLATEDPFQDEDELPNAIKQVEAEETVEDNAENEPIVQLEQRIASTVHQNAASLESQQRTWLALSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF03</accession>
    <name>A0A0N4UF03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS926</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF03"/>
    <dbReference type="WBParaSite" id="DME_0000598701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000598701-mRNA-1"/>
        <property type="gene ID" value="DME_0000598701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000598701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40377" checksum="F8FC32613F6C6265" modified="2016-06-08" version="2">MIGGSEDQKIVCNIYIILEKNCFSSYPNSPVSKACSTFDSLTASSTSPLMQLSSPIADTIATAAAVNGTTPQSQQQQWRPVLQNGAYHQQQVVYTQEQLQQQMPMIGQVNAMKRKANPRVSTAMHEYPNKMMPTQFISFQHSTSYQQSTCSPQFVAPSSSVMPPSPISQYNGYDGGPVGQWLKQTPQPQSQSQFTRMELRHSVQARRSIPSPNQASIVMSPTDLAVPRFCGNIARSPLTSMPQISKHSFPQQQQMSQQQLHHQEQQRQQSSSQPPPSLSLSSMPTANTPENVSFNPHFPNQAFNYSSAVSFDDFDMYPPYELFDFKLVKGSRWNITQTKLINLQFDIENEATVQVVKQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF23</accession>
    <name>A0A0N4UF23_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS951</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF23"/>
    <dbReference type="STRING" id="318479.A0A0N4UF23"/>
    <dbReference type="WBParaSite" id="DME_0000601201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000601201-mRNA-1"/>
        <property type="gene ID" value="DME_0000601201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79940at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15739">
        <property type="entry name" value="FYVE_RABE_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000005">
        <property type="entry name" value="RABaptiN (Rab effector)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="374"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="289"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000601201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51558" checksum="98A6B0C931C6039D" modified="2015-12-09" version="1">MESIHNSTSENAEPSKGGIIEFEKSPQIESKAIQDDSTVRIPMGKAINDNDNAIHDSLMSPLNEFSCEMCRNYESILTKLQDGERDLKEQLIAAQHLVERYKTELSGERQFRNELDTKMSSLSSEAGKETKIMDDVNEENQKNLAKLEERYESLYQLQRSKLQTLKEKLKFMDSEMQKMSKKYSKLCGVNRKCASEMQAQAIELPQDIDQLQFLCLQLREELIETRAIKEHIETELKDEVTMLQVQRKEDEIAKHRLAQALTDQVNGVSEELGLARSQLSSLHNVSEKAEEMERRMGDYRSFIEDLEKQIKSMQKDRSELEITLASYKQRCTALQQELDTSEAVQKDFVKLSQNLQIELEKIRQAEQEVRWQFDEDVFACNHCQSIFTKSRSKLHCQHCGKIFCSACLTFTVPSGPHRRLAKVCQVCHTLLSRDTAPFFSHTVHDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFK6</accession>
    <name>A0A0N4UFK6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enkurin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1124</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFK6"/>
    <dbReference type="WBParaSite" id="DME_0000622701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000622701-mRNA-1"/>
        <property type="gene ID" value="DME_0000622701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000622701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21007" checksum="79B77DBBBFA809EB" modified="2015-12-09" version="1">MENEICFQKSRYAYCKAKQISRKFDPPEFCEYTEQKRESFVEMKEKKFKNGHARSISSDNGDIYDPIQPTNGCIANGRFGNDDFSVPQITKFHIEKTKDTSSPIVEYKLAQLPQLEEYKVERMDAATLYLEQRAALKKTNSSCINKGSDIRRLDDKQLAKLNANRALLKQQQDELRSLGILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFM2</accession>
    <name>A0A0N4UFM2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1142</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFM2"/>
    <dbReference type="WBParaSite" id="DME_0000624501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000624501-mRNA-1"/>
        <property type="gene ID" value="DME_0000624501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870094at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="1">
        <location>
            <begin position="34"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000624501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59386" checksum="A2F1F585AAEF5F3E" modified="2015-12-09" version="1">MFLKDSVSTNHVKPTISASTSFLDSIGRQKNQRSLSATSNFDRRLNSDARNPELAMQNALAKVDAIQIFVYISETSPETCVKYSHAILVVLLNECKNLRSTVSRAAIVAIGKLFCNIKSKIDFDVEKICSILMQKAGDVSNAFIRDDAYAALDEVVKNASPMKVLSGLIASGSKSKNSVIRTSCASLIVKLIERIGPSQALSCPDINKLLSVLTAFAQDANPSARYQGKRGLDLLNQEPNQFEKMIQKFLTATEIRNIHGIIDSIKKRGLEISNLDTISSSSLPHRSVNCRQNSRYRANKIPDSIQSDLSEFSWERRSAGLKKFHQRILNYARATTHDTKLMESFIGRLNDINSKISQEAMETYIKILPLTAKYFSTETSLKLILTQLINAFMSHLSSRSEEHLQIAQKCINETIANIDNTALFPALSAATRQANIKQKPFMLLSLNTVSKALYETRPRQVETIALPVLWDLFKAPPHLQNDPGVRQAVREYAIGLRTCIGEANLLNMAVSQLTPSQKKSSYRIALESRTQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFY0</accession>
    <name>A0A0N4UFY0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-like GTP-binding protein Rho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9483</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFY0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFY0"/>
    <dbReference type="WBParaSite" id="DME_0000637201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000637201-mRNA-1"/>
        <property type="gene ID" value="DME_0000637201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5783773at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000637201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22824" checksum="D1FB9E723A78657C" modified="2015-12-09" version="1">MTKKPLKFVVVGDGGCGKTSLIMVQAGGEFTDNYIPTAFDDYAIEALINGKTKVITVCDTAGEDDYNSLRPLSYPDADVFIVCYSVERPGSIKSIREKWLPEIKKFCPEVPILIIGNKKDIRCERKALTTSSHDKIKDSNFNGLVDIDEASALACEFTPHKVIECSAKTKEGVRQVFDTAIRVASSHRSKKNNRVLSSIMKLKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGH8</accession>
    <name>A0A0N4UGH8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1328</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGH8"/>
    <dbReference type="WBParaSite" id="DME_0000659901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000659901-mRNA-1"/>
        <property type="gene ID" value="DME_0000659901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="7">
        <location>
            <begin position="86"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000659901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40329" checksum="1F20EEE7895ECED4" modified="2015-12-09" version="1">MDYVKKNGLEIPLCFNDPPVQLGMTMPNASNFSVLNVKDLVGGDRWIEVVEVKTQGSRQMALSDFIDYYTKEEEREELLNVLSLEFSLTPLQDVVKSPEIAKKLDWIELYWPKELRQASNPLMYPKVQHIIINQEKNYILVALRISILISVIFWMIEPTEQNLIMYEEWILKGDQNETFFGDIVEKCCRIELNEGQTFIIPSGWIHSVYTPEDSLVFGGNFLHSFSIPMQLRVLRSEDKIKKYRYPFYNEMLWFVIVGVVEKTTGRCHLKNRSAIVTSQLSSVNSFSFLYIYISLYIYTSVYIYLYSIFILYVICRIMMYKLERSKRRTWNSKRATLILTPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHD7</accession>
    <name>A0A0N4UHD7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0764 protein C16orf89 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHD7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHD7"/>
    <dbReference type="WBParaSite" id="DME_0000696101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000696101-mRNA-1"/>
        <property type="gene ID" value="DME_0000696101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5949187at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000696101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="41350" checksum="63643BB688489F97" modified="2015-12-09" version="1">MAPPLNQSIDWKWAYLISLILNALFGIENYHHEHISQLTFEDYINNCQYFPHYNSNQKIKKQSKKSPIFIKNGRYSKSFFSDGTFTDQDFSCFAEILSQNCNKINYCNISQECLMRMFNTTISTEHLIIRQVLYLATLRSLPCSYQISEYLFKKRKQTLEEFIAICCTNILEEFKYLYDLRRTESNIYEKMMEQVLVCGQFGFIEFGPVDLLQKILNWQHPKYGCYNENMQWVPSLHDYAGTITHGNAATNFIFDCSVHLTSLAGGVLTVFLLFLLDQNYLRHMQFVIDDLAFQKIPAEYMFRKYRSNDWVSLRPKRILPLYPPATPASHPRLLGRQSDTMLEIIIYLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHQ4</accession>
    <name>A0A0N4UHQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1622</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHQ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UHQ4"/>
    <dbReference type="WBParaSite" id="DME_0000709601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000709601-mRNA-1"/>
        <property type="gene ID" value="DME_0000709601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000709601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14306" checksum="2E708B8F23638DBC" modified="2015-12-09" version="1">MTSLLAGIVEKNLSLNDLHIDSVPRCIGRYDMELGDITPHNVEQLRRLNQAVFPVSYNDKFYKDIVSAGELAKLAYFNDIVVGAINNDIAVKFYTHHGFQIVGVAEKYYKRIEPDSAYILTKKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIU3</accession>
    <name>A0A0N4UIU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1808</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIU3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIU3"/>
    <dbReference type="WBParaSite" id="DME_0000754101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000754101-mRNA-1"/>
        <property type="gene ID" value="DME_0000754101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21911">
        <property type="entry name" value="CC1_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000754101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47513" checksum="07C1C1287DB1C2BB" modified="2015-12-09" version="1">MTWSRYPLAVFSACSQSHGFDERQVNVPVCEENAIKIGRSVAHWKPGNDNAIFDCKVLSRNHAVLWYEEGCFYLKDTKSSNGTFVNNERLSKSAEESSPRQIFSGDILQFGVEIVENANKVTHGCIIAIVRLFDCNGDEVLAPETSTCMINRETDSQLPVVSAPLVNSYQLFQLQQYIREAVHREKIIEQKLSTLENILFTTEKATESSWQALISEDHLLSRIEMLEGQLSLYSKNLLSDKVKEQMNEMIEDKSKFELMAKESLRRAQEEKNEALQRLSDVEHCLVNTAVESNFYLRDSLSQTYIKLSEAKYSAACNNYNLQGLLNSSVGKSVGNGTAEKKKVAVEHIVVSSENGNVDNVHDDGNNTSLGLMQNMSSICRIMQEKEMVISGKKECFEDKKMQFPDYDIQVTNFLVPIGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJC3</accession>
    <name>A0A0N4UJC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10160</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJC3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJC3"/>
    <dbReference type="WBParaSite" id="DME_0000775001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000775001-mRNA-1"/>
        <property type="gene ID" value="DME_0000775001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858241at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000775001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18468" checksum="B225500466BA39D5" modified="2015-12-09" version="1">MEENTVTINMNHEIEQSEEEDFRHPSDPIPSTSLSYPHFLPLNLFSLSQNGSHSWYVIFEEYLQMQLDTIRHQYVYEQAGNYRQLSNSIIWDQWICCLAKNLTYEQWESYWVNYLALYGTSNLPEHIISTFNYALEQYQNLTKWLDERQQYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJG8</accession>
    <name>A0A0N4UJG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">JAKMIP_CC3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10175</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A0N4UJG8"/>
    <dbReference type="WBParaSite" id="DME_0000780501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000780501-mRNA-1"/>
        <property type="gene ID" value="DME_0000780501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="720"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1728"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2459"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2823"/>
            <end position="2871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000780501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3104" mass="360810" checksum="F5207573356B4F41" modified="2016-06-08" version="2">MECLSCNIYKSQIVSKDREIQNLNNLLTNQRLKSKAKLTQLQQAFQSNLSDHHVNGDLVARIIGLENHLYHVEEENALLKSDLSTRQMDLDHLTLLLEQIDEQIKTQKFELLECDETSSQVDVGNCPDFERLHAQIVYKLYFNLRTAMLLTEIHKAYGFSFFYYNILLQDNKIMELNSVILDKERQILDLQEMCREQDQVAQAKTKAFQIMQHKFMEASSRTTKECSTETDEKVFTEYNNNALNGCLTASSSRLIRSVNKTFLPGHAVMQIKTGDRHSPPPVDPSEDHSSFTTEKEIKDIDVGSKNSERNKNRKRVTFDLPPQQNEENGNKDDVAQTIIDLTSENDELRRIIQEMEMNGEHSAKDRIEKIILKLLKLEAELEQLRHDGKNLVFKARAASQTRIRELEEKIASMETKYNIEDLNKYFLSKNPFKLKVETMKSKEETLRNAREWLLEENGKLMEQLSSLRFQQQKIDDLREELNESLSEREKIRLKLENDRELIVKLADDLEDTRATATVLLEQKISILDDVERLKGLVLYSVCNRDSKIVKMTIWSIVNMVYMVHEESIEEMWRFERILSNVWRADVLLEALEALEEYIEVLETDIFIYEQHVGILRDSLGVSQIDRRTLIKSKAFETKLKALELEKDQMVKINNDEKLRIKALTFKIRSLENDNALLVANLDEIKSKLVENNDNKNTKSDSAVSLNSTLSAKIINEHEIFEQNELKIENLRKIINEKECEIDRLKTISIRKEYEEKKNKEKYDNELLNMEKKISILREMNEQILEHWRETDELLDEKDKEINKLREENEKFKKDSNSTDQDEIIDLVRMGQEMDSLREECERLRRDLCRVECMNFELQNELDKQLEKARMQENDLTQSNDMMLDTIINNLENQRGSSSDLLNQNHMEVSVVGEGKYHNHKFISIDNGQESARKILDCDGTDENAPLEFRNMFLSNTESCAFSQTHISSVLTDANCQTTVSTSETASQCENVKENLLNECCHVFLQKQLSSALVDDSCQISAILNSDLASQSEASCQPKVPTSEIASYFEASCQTIVLSNEAASQCGDIEEILADVYDVFSHKQISPILIDGICQTIVSANDVASQCEDIMENLVTVHSDLQSVGLNESGLVHSDQNDSNECSASPSQFDMVSSISVVPSKIFQNENLCNIGKDQILEQNLSLCECVTETTKVQDSLPENINQLMTLNAELETAVNVLNGEIWSLKQQLKAILNEREHLVDKLEEIVELREKDRLEAQQRESEFEQQKDMTETYRRQALLNENEYSRKLVEWQEKEKEMEKHRAELEQAYQQLTHYYQELQGAYNALYSQFYAQKSDSCTISDLTADMIDTMQTQYSENLSVISQLREKLDFANNQIIDLRLDYSKQLSYLRLKIMALRDNELKLIKDLVVEHTALVQSDFLHQESEFEQKLMEFINQIVVEYTEYINENKQILGKIFDRDSNPPSLKNMTLLQLSELVRNLFKCEDQFVNGSVNYTGAVKAIFCPSKTQLDILATRLTSKTADNDALFRCNAELAHTNVRLQNEIDSLNAQIIKFQEKNYTDISVGLCIDEDVSCCKSTQTQQSYEEICVSELHSVCDHHMLKEGEKLFNGSERLEIQSNFGLSESKRIDKSVDLQKVEVISDEADENVWEWNNFEEEALSQAEVHFEARNGKEHTKQYSPEEYGDSLIIPQICKCAGNYNDLCNRHATLEGKMSENIDNKFKNDENLSKIVEEKQRITEKSLEYEEKLENQNKTIHILEEKNIALSNELEQSYHSLETNLADKYSLIQELEDNKLLVERLISQILPESNDAGEETKNKIERLCKEINSIRAQNDLLKDAETKLMDLVEERNIAVENLQNDIVIMASKIDEMIIAKNNLNVDKEELGNKLASVEKFYKNELKELRTKLEEYENLTEKNRQQNQLASVETFYKNELEELRTKLEDYENLITEKNGLQNQLASAETFHKNELEELRTKLEDYENLITEKNGLQNQLASVETFYKNELEELRTKLEDYENLITEKNGLQNQLTSVETFYKNELEELRTKLEEYERRYFIEEHKWNNEILAAKREIEIVKKNLQTLEEENRDLKQQLDITEEKCRKQDFVEDMHKNKMEILYSKLKTYENFTGIQEEKAIQTDQEEARRKIPTCVQIFSMDQKTLDKTHLNGAEVKDDQKLCRSSSSTTGFSSEGMLANINDRIQQLQEIVSSFSVDLKMCEMVNDYDNDNVFTFTLEFSSFSYNVTYWSISRRVLHMFVGNFLAGRYFGNRGTDEILGRNGTYVRELDHFDKLFDNFIENGNGITTNMAKLREITDILSVDILSINSSENEEEMIYDGWNILCNLFQRCLNVCNIQIDQFKGQLQNLEETRFSINECVHCLENTLTNSLITTELDGSVDMNEKKIAKIDNALNIEAIKCLIGYDSTKINLFQKFFNMENKKFKEILEIIESVKSSEIFQTKIFSLVEENEKLKDELKKLKEEKLQEIIKCEKLERMRSDLMKAVDDYENLVEMLKEFKNKTKQEIFAELEEIRGSNSQIWNELDSLKKILFTIKNNDENQYNKFEEPMETMKNMRKKISILENDLIEKDFLIKKLNSTKQKVNKSSQTLLIENNQLCASEFITDNINGSVNVDDNCNKTGQKLTENNEELRRVENNIGNPRKLDIDTQLKNERRFSIEEEDDSVENADGGKEEVIPDSLSGMQLNQVPEDSRITDLISYEIKPCAKCLKNNAIMSKLKHENMRIAKELCNVRRLLVTRENDLQMRIERELVLESNLKDFQLQCDSLSVELTRNRSIYSHKQNSQNQRVAKLQEKISETEQFHNEELEQFIDELHIAEAKLRSAENIKKENEKMIEQLQNKIREWATRCSDLIRENEALLRANEGVKTLESIISKINEEKQHLYHELCDIHAERTQLLSIRDHLCVCLDEANTQIQQLREKLHLSINDRTAKAMKIIELQAEIHAIKVKLSKVGSVVDQSFYENDYGLIDENKRKFFAKNRALSEGSLSEKSKMVIFHKNMATDDNSKTKNVRESSQTSIIPSFNKQFASLRIFRAHEKSDSLIAINNSGNKLISRSVSYFIRKFIFLLFFYNYLELSNLAPKDLMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK25</accession>
    <name>A0A0N4UK25_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase [NAD(P)H]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2173</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK25"/>
    <dbReference type="STRING" id="318479.A0A0N4UK25"/>
    <dbReference type="WBParaSite" id="DME_0000804801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000804801-mRNA-1"/>
        <property type="gene ID" value="DME_0000804801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805987at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000804801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42464" checksum="9A35D084EA9AD915" modified="2015-12-09" version="1">MNGLSSSSVLDATSECTTDGLNSSNGHKKTAHAKISPLLDSELFERSLYIPLHNRINQRIQDGSPFFSLEFFPPKTVNGVSNFFSRVERMREGNPLFVDVTWHTGSDPGNLKKETSSTSIAAGCLNYCAVDTMLHMSCINYSKKQTLRHLEQSKIAGLRNILALRGDLQKQIGIRVRCASGESLLRFAEQYELFVTNTYLRYQSMWNCADNQHSNKIDYILISRHWKRCILDTRSYRDANNFHGSDVMVRHKIRIKLIICKFNHDALSVVPNITDSPVEPYVRNCGPPTQEEEMISVIHKLKTYKTRRRWSLGRILQILPGLGCSCDDQISILKKIHIETSLQVSACHRQYCQLFYRLLPSIQLAGQFFEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK65</accession>
    <name>A0A0N4UK65_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2218</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK65"/>
    <dbReference type="STRING" id="318479.A0A0N4UK65"/>
    <dbReference type="WBParaSite" id="DME_0000809301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000809301-mRNA-1"/>
        <property type="gene ID" value="DME_0000809301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000809301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="566" mass="65491" checksum="32D8BC0F6EF61EF8" modified="2015-12-09" version="1">MIEHKSSKQMNGSLMNMDLPCSSKCDVAKMEHLSSEEGIIIDLTNDNDNDQSSSSSIASPKNEEIRDDLSNIGEFSEKIDEIDDGELEADDISNVVRQYSMDCDFGRYISQPGTADCIELRSMLAKAVQLEKFEREVKKIKSHLTGVGEFLMMISRIGTENGSTRERITLDRFGRKVENTVYKRNWSYHPEIVRTIAAVDSTTFSIRLQDGVLLSELPPPPPHPKNPDDIRKLVRSKMVRCKKCRSRFIEKNLYERHLRDKHSTEYIAYLIQQEEEIAEQRMAELEANRIEEIASGGYIPPESEIVAEGYDIEVEKIPLPGELSGGVPARFDKNGFLRQPKRSYKKKVSPQCLFCDKRFRNEVSLKKHLVKKHPDAVEFIQCLRCFKAVKSKKDWETHDCDLTFMCFECIPLRNLCTQQRLLNHRAKFHRGTNSGFKCNMCSLKFLTPRKLRKHKKMSHVFTKTYPCHFCDEIFTSECSVTTHERIHTGIIKFECRICDYKCNRYTWMEEHQKEEHGYICSVCQHKCAEWSSLKDHTLMEHGGYLTSESNAGIRSVWFKGLDSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKL2</accession>
    <name>A0A0N4UKL2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2314</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKL2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKL2"/>
    <dbReference type="WBParaSite" id="DME_0000828401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000828401-mRNA-1"/>
        <property type="gene ID" value="DME_0000828401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000828401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18611" checksum="83A4844A6F1F97AD" modified="2015-12-09" version="1">MWLNNGHGKYEELPDERAFFNAVKTSHKVVCHFYLPSTERCKILHQHMQKIAPKYLETRFVCVNSEKFPFIVKNLNIRMIPTVAIIIESKTVDYIRGFNDLGDTDEFKTQTLEWRLAESGVIDYDGPSGLAGCGTNVAKFSKVSANTQRKMIRNGNNYGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW0</accession>
    <name>A0A0N4UKW0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS2402</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SWP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKW0"/>
    <dbReference type="WBParaSite" id="DME_0000839601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000839601-mRNA-1"/>
        <property type="gene ID" value="DME_0000839601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055375">
        <property type="entry name" value="Ribophorin_II_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23861">
        <property type="entry name" value="Ribophorin_II_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033762611" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II second" evidence="15">
        <location>
            <begin position="273"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="385"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="16">
        <location>
            <begin position="547"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN52429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000839601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71228" checksum="6A3D5395C5598889" modified="2015-12-09" version="1">MNAPFSLIVLLWIVKPLFSATPFLNSYLDETSRQYLQKVFNDAANTKKLSAIHYGVSGLKILGTPLNIKQQQIICENIPKYNIEGIEDIYHLLSIATNLNKCDIGQNEIAGKTVKEVLANTGATSKDIFFALSVAAMIKQKLANNEASIRLVAALKTNSTPHSLAYGLNAAALLDMEAAARFLTYADDLISQADEIDGKYLQLENGLPVTALAVHGIYALADKLKKSPSIKSDEAIKLTNYLLSRKMIQLDYAAYLLTITLKRLATNSFQVPVVFSLASKIEVTDITQPIKLRICNVLGESVGPLSITLDVATHVISKEAIAVTKSFTKVTTDKTGTLYQVSLDGARRRGFYNLALTAGSQDKRLIGTNGVSIVVKLLAKIRIEDISIAVFDRELTKPTTTYSAKEGTKLGKVLEADDHTKIEIKFTVREAKSNDAVTVHQAFVAFVNQETAQEIIYVATADSSNTYIFDMAIFYFFFLDLDKSWKDFEGFSGKYFVRLIIGDAAISYALDWNLVDVNMKLPSLPSTPFKKSELVIYDPLPIIEHIFREPEKRPSQIVSDAFSVVCLLPLLWLRVGINFGNMPLSPLPMLFHAGLFAIFGLYFLFWLHLNMFQTLKYLSVLGTFTFITGNRLLRTMGQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL49</accession>
    <name>A0A0N4UL49_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2479</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL49"/>
    <dbReference type="STRING" id="318479.A0A0N4UL49"/>
    <dbReference type="WBParaSite" id="DME_0000850401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000850401-mRNA-1"/>
        <property type="gene ID" value="DME_0000850401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF19">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000850401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29184" checksum="7CFEFAC92090E9AA" modified="2015-12-09" version="1">MFEGIEWRGEGDSQLPFDFVDELFDENSAKCALFNDETIAQFRRERRKEERVRRRKNKKLSNSITELKMDINIYIDFGFSYAMNDKEIKKLVRQMGRVWGLQKRNNRLKITLLSPCNRFLAESRREILCDKCIYLSPDADLLPLSAVSSDYIYIIGGLVDETGAGSLSRNKADALGIPAYRFPIVENMRKGVKGTFNLMLSINNVVEILIFYVLCGRWDKALGLTIPKKSGYLPIYDEKLSLVSQNSLILLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULR6</accession>
    <name>A0A0N4ULR6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2644</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULR6"/>
    <dbReference type="WBParaSite" id="DME_0000875301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000875301-mRNA-1"/>
        <property type="gene ID" value="DME_0000875301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000875301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10710" checksum="E011E38C17624095" modified="2015-12-09" version="1">MDRRMESFANFLLKSEFLRLSANSVADLQASRNSDFHCPVVHIDFIVEFIQVYSCELRSMIATIESNQIFRTNWLCARLFISFSFFNANCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM71</accession>
    <name>A0A0N4UM71_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2778</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000079">
        <property type="protein sequence ID" value="VDN52805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM71"/>
    <dbReference type="STRING" id="318479.A0A0N4UM71"/>
    <dbReference type="WBParaSite" id="DME_0000893201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000893201-mRNA-1"/>
        <property type="gene ID" value="DME_0000893201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000893201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25137" checksum="874D6132ED9DF206" modified="2015-12-09" version="1">MEKLELFLKWLENFDISYDGIELRKCDFGYGIFAKRDFHINETILSIPLQLLITPSSVVQLSNIKLKPFEILVLFFILEEIESSLWSPYLQILPITFTTLAAAGAELDISYLPLNARTLWEKQSNEMKMMFNKTLQAKQPLSTRKYCIDVGGPSSSGDEILQRLSCLKKLDPLLLTEWKSVRKSKTMAYARFKGKFCNTSVINVHAPTFSEDSMQNFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMF3</accession>
    <name>A0A0N4UMF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2816</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000082">
        <property type="protein sequence ID" value="VDN52843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMF3"/>
    <dbReference type="WBParaSite" id="DME_0000902601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000902601-mRNA-1"/>
        <property type="gene ID" value="DME_0000902601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000902601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16974" checksum="844B8AFF3B04E0FA" modified="2015-12-09" version="1">MSSKDKVPSPTPSLSSSSSASSTADDINYSRNIKRMLNHLKDQISKDGKSQLQRLLGNIDNPQESKPMKGVSLGELNSADLYFIIVAIIERRVIPFKIENRSLKIELKNMKERIVALEDQIMGINRRRRAVIGVRKGKELTNIGGSSSHIPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMG5</accession>
    <name>A0A0N4UMG5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mevalonate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2828</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000082">
        <property type="protein sequence ID" value="VDN52855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMG5"/>
    <dbReference type="WBParaSite" id="DME_0000903801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000903801-mRNA-1"/>
        <property type="gene ID" value="DME_0000903801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000017">
        <property type="entry name" value="MeValonate Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="6">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000903801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="542" mass="58652" checksum="6CE9F9A12BEA9A27" modified="2015-12-09" version="1">MWKKIRQDIWCKMANIHGSPVSLSSQSRALTNDSNNRNQSPMRSLTSASGGLYISAPGKIILFGEHAVVYGRTAIAGSVDLRTYASLFTSADGRIYLSLPDIGVEKTWLLKELLKAGERLAEYPYEDDSPPSLEVLVPIARKLSGSCEDQYGVQHLAILAFWYLLLGVVQRKRNLLAVKMTVRFKLPSCVGLGSSGAYCVCIATALLQSSGIIPAPSITADDEGSLTWDDQHLDMIRKWSAAAESLIHGRASGGVACFKPGTQIQHLRNLPYLRVILVNSKVERNTFRMVQTVKERLKKFPDVIESIFNSIDAISHDATKILNRSGEENGDPEKLVNGGSGRSSGEPCSDNDHNSLQPGLHQQNTTMTIGGKQSPNFTSYSAGGKRSSNESAASGTSLGCVTPEKVEKGELVDTYAKLNDLCRINNQLLIALGVGHPKIDQICTLLARYGIHPKMTGAGGGGSVFAFLKPDTSTTVLSMIKNELTKLDYEVWQPPLGGPGVICHVNKPDLFNTPNSAATTPHVTITNSPQSTPSSTAHRHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN12</accession>
    <name>A0A0N4UN12_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed DNA polymerase, eukaryota, reverse transcriptase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10631</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001230">
        <property type="protein sequence ID" value="VDN60658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN12"/>
    <dbReference type="WBParaSite" id="DME_0000927401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000927401-mRNA-1"/>
        <property type="gene ID" value="DME_0000927401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000927401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12698" checksum="598D128E91840F59" modified="2015-12-09" version="1">MSFLNPASISLNTGDDELGGEHVPAVGASVVIEDELDESSGPAISTGREDVENAYGDCSSSDHLLYLVLSKGNGYIIAALRIIWGEIVKRLSYLKKLEWKPVNDRMASTRFASKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UND7</accession>
    <name>A0A0N4UND7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3126</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000106">
        <property type="protein sequence ID" value="VDN53153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UND7"/>
    <dbReference type="STRING" id="318479.A0A0N4UND7"/>
    <dbReference type="WBParaSite" id="DME_0000941501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000941501-mRNA-1"/>
        <property type="gene ID" value="DME_0000941501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF139">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="88"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN53153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000941501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45348" checksum="1F6555A17978E66D" modified="2015-12-09" version="1">FDESSGPLIDIWSEPNKYREYADVLVAPKFINSFLRLLKDQNITAFRIIKHDIQREIDRQKRDLQRSTERSKRSSNSVSNINDFNLIAYHRYDKIARFIYDLAEIFPELVTTINITKTFEKRDMVGLKIGKKSPYKPAIFIDAGIHAREWIAPAVAIYVAQKLIMRYGRDEIITKMVDKFDWYVIPVANPDGYEYSMTTDRLWRKTRSRNLTINKWCVGADANRNWGYRWGEAGANRSPCSNIYPGSKPFSEIEVAGIRDYITWQIPDLKIYVSLHSYGQLLLAPWGYTHDRPKNYYDQKAAAQLAVDAIRNRTGANYNHGTISELMYTASGTSIDYMQDKGVPYIYGIELRPEDGDNVSGFTIPARYIKPTGEEMLSAFLSMAQYAINNKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNH0</accession>
    <name>A0A0N4UNH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10666</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001234">
        <property type="protein sequence ID" value="VDN60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNH0"/>
    <dbReference type="WBParaSite" id="DME_0000945201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000945201-mRNA-1"/>
        <property type="gene ID" value="DME_0000945201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019207">
        <property type="term" value="F:kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000004">
        <property type="entry name" value="Protein CBG05668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF5">
        <property type="entry name" value="GSKIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="3">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000945201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22385" checksum="9A0D8289D3E11D2C" modified="2015-12-09" version="1">EIYSSLPSLTKVSSHNRSLHGTNPQSRGDSSLELEAIAAVHELSFAVHSISVSEMLPRTPELIFVNVTTTEGQPYCIELTLKGWRITSLRNDCMHGDFKQLELFTKYYESLYELMDFISPGYRSRFSEKLSQRLKLLQVILSTSNEPSEYFILFQAGENPEIAAPFSSYACTPLQESPQKSPTSVVSFAFGSANDLDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNM5</accession>
    <name>A0A0N4UNM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 256 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3194</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNM5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNM5"/>
    <dbReference type="WBParaSite" id="DME_0000950801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000950801-mRNA-1"/>
        <property type="gene ID" value="DME_0000950801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000950801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16467" checksum="042E6552D598006D" modified="2015-12-09" version="1">MADWASWMKWVFPFPPKGIGSSGIMPTKDAVQFLLVPSSNIIRFAGISGALAVSFSAYGAHALEFNKINDKRRIRAFEVGSRYHIIHSVAILSSPFARYPLLTASLFTAGIIFFCGNCYYYSFTGNEIARKYVPIGGTLFIIAWLSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNR8</accession>
    <name>A0A0N4UNR8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3233</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000115">
        <property type="protein sequence ID" value="VDN53260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNR8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNR8"/>
    <dbReference type="WBParaSite" id="DME_0000956601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000956601-mRNA-1"/>
        <property type="gene ID" value="DME_0000956601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000956601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19802" checksum="BF2B9297734241BC" modified="2015-12-09" version="1">MSTLKSLVIQRIEPKHARNLIVMTKEEAEFQKMLDQVTNTEEKLRSDIRRGDVDGFIAFDGEEPIGMVLFGYSYSTWVNQIINVESIYVREKYRRFHIGKKLWMEAVKVAKERGIARMQWICLNWNTNAMEFYEKMHARNLSAEEGWLLYKLGSQEIDKLVADHKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNS2</accession>
    <name>A0A0N4UNS2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3240</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000116">
        <property type="protein sequence ID" value="VDN53267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNS2"/>
    <dbReference type="WBParaSite" id="DME_0000957301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000957301-mRNA-1"/>
        <property type="gene ID" value="DME_0000957301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447510at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF1">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000957301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30089" checksum="8018FEACD763446E" modified="2016-06-08" version="2">MNVTEDLSQFFTDEPIQRLDSSVLRRLNPRKYWTVKKIIDQMGSLSAKAQGLRKSLTTYEKIIDSDERQILYILWKKDVEYSGRNIIIGLLKIGYKNLYLTDEKNQTYQTTPLCILDFYIHDSLQRRGYGHTLFDYMLQCEKSSASEVAIDKPSDSLIQFMGKHYDLKDPIWQTINFVVYASFFEHIEPCNQDLHKKQQQNLSSKVQYVERNYPSRGRDNVGDIMRSATELPTRIYSAPDTPLGRKVARDLGHQMIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP62</accession>
    <name>A0A0N4UP62_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3347</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000125">
        <property type="protein sequence ID" value="VDN53374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP62"/>
    <dbReference type="WBParaSite" id="DME_0000973101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000973101-mRNA-1"/>
        <property type="gene ID" value="DME_0000973101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18814at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000973101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51589" checksum="36932A805F2D7C22" modified="2015-12-09" version="1">MVRSAKEEAEFFSRIILKITRKSFTVAISNFFRFTLFLNMKWWLQVILLILYAFWKDFKPGEPFLFKYHVIFLNLTEQQLNGEIYPYWTYSYLIAMIPIFLLTDLLLYKPVLMCENIGYIVFRVSLVFLSSVLSQQIGHVFYGIATASEIAFYSYIYASSDKRDYQRITSWTRAASMSGRTVGYLMSQLIIITKLGTYLTINQISLASPIIALIIASCFPKVHWKTLIDRIEKTPGTIDDNNLKLPRTYLAYCRYRIEKMYCNAKTNYSIGFVSKWSLWWAMTTCMSLQVSAYAQTLWGEVQEEERTLNGFAEATYTASATTAILIMHATRIDWDRWGEIALVIISTVDCALLLLFSRTNSIYVMYGCYIGYRTLYQVMITIAQWNLARKMVCCSYGLLFGLNTFIALILQTILTLVIVDKRGLGLNARIQIRYSSFSTFVEDYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPB2</accession>
    <name>A0A0N4UPB2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3400</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000130">
        <property type="protein sequence ID" value="VDN53427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPB2"/>
    <dbReference type="STRING" id="318479.A0A0N4UPB2"/>
    <dbReference type="WBParaSite" id="DME_0000978601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000978601-mRNA-1"/>
        <property type="gene ID" value="DME_0000978601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8112755at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000978601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21094" checksum="199224E5349289FD" modified="2015-12-09" version="1">MYWGSNGTIIRKLKGINLSNSNEGLWFVINLCESKTADIYGGAIPFHMSIRFDERQIVFNAYINGAWGPEERAANPMNKYASLDVRIRTHHDHFEISCDRRQLTTFRYRLPLSMINRLYIDGGLYPYNLEGFRGRYYRVICNSMIDSKWGEEERIEAMPFLRFVDFELKIKKEEQAFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPH5</accession>
    <name>A0A0N4UPH5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3443</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000134">
        <property type="protein sequence ID" value="VDN53470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPH5"/>
    <dbReference type="WBParaSite" id="DME_0000986201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000986201-mRNA-1"/>
        <property type="gene ID" value="DME_0000986201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10651951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38624:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38624">
        <property type="entry name" value="PROTEIN CBG08397-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000986201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25948" checksum="8C3FDA961A3A1FEE" modified="2015-12-09" version="1">MIAWLATSISVLTPYSCGRFTSQIANLSDVSPCWEYHAHRRMQTPCQKKSFNTAATWTFDTMAGDDGTITLFHDLLQDYDNFNFEVLDEVEYAESIDKVVQLENHVIDLYFVRRKSTNFLRSSARSRQDSETLRNSFGIKNSFKDDKARRTQSFNCGSLHSSKKMEKVGKSKTTLQVKSEEHAISTGASTSRRRSFKFGVRFVSKDLKEKNEVENGECLVEGYQNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPI7</accession>
    <name>A0A0N4UPI7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000135">
        <property type="protein sequence ID" value="VDN53482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPI7"/>
    <dbReference type="WBParaSite" id="DME_0000987801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000987801-mRNA-1"/>
        <property type="gene ID" value="DME_0000987801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000987801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35730" checksum="B72A8899CEB9132C" modified="2015-12-09" version="1">MDLQLISSTSEDCTKTVETNDNAILYGKREQSAGDSTMILMSKEEQPHMMAFFVCGFSTVDEDLPKNKTIKKSASADENSLRGLFRPLPSKRKKTILESKSYDERSVISSQETESADGIGIKTDSNIPPGFWISPTNNKLPKKPELGDGDRNRIDRDGTFIKSDASSGSLKNNERSTSDDKTEDGEENFEYNHNGHVVPEQLEPEEEKEIEGNSQQDLNGYDASEQPGSGDGNEIFEGNSMWDRSDKVPSDNTDESGESNLKKDLNDHNASERPGSSEKSDEDDWSNMRTPPPSSRNHPFLAYITWAPKLEKSTIHLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ42</accession>
    <name>A0A0N4UQ42_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3631</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000160">
        <property type="protein sequence ID" value="VDN53658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ42"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ42"/>
    <dbReference type="WBParaSite" id="DME_0001010901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001010901-mRNA-1"/>
        <property type="gene ID" value="DME_0001010901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001010901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17862" checksum="64E46D0090109F36" modified="2015-12-09" version="1">MEEIQDVRSETDGSGIHQTATNYQQSAPMIRIAAQRPLSESQYSTLQDVKNSLFTNFRDFIDDLEEYAPTIPDAVTVHYMRKSGVDNTDPRLVRLFSLAAQKYMSDIVLDAMLQARMKGLGQMKKGTKETKFALTSELLESVLAEYGIKIRRPPYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ49</accession>
    <name>A0A0N4UQ49_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved oligomeric Golgi complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3646</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000162">
        <property type="protein sequence ID" value="VDN53673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ49"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ49"/>
    <dbReference type="WBParaSite" id="DME_0001011601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001011601-mRNA-1"/>
        <property type="gene ID" value="DME_0001011601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001011601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="640" mass="73236" checksum="0BD97D37CEBE2C79" modified="2015-12-09" version="1">MSLEGDLEDCIWGRSDWQEYTKKLVAADDINEQVLLERVEKIKESIKRKIRKAVSLGNLQEIISRDMANLCETSETLSTRFSTCYERLHEGVIQLEQMSALKLLLFAINRCELLIIRLNTIDEVVKRSEIICELNEILKENPCLKDINRMSEIVFVKIPCLTKETLAITVQQLKSSMGSLNAPLASCCLRALKNLSCYDSEIANLVDESAKSLDSDFLKLGLASEMDTKIITQLSNKMSLEQFALLGDNVGKMFCKKFAEILSNRIPVNSSSACRIVQLFSKIFSTYSLATIGPLYDALKPFKNAILSQSFNRMFAIINKALDDPLLRNPAIEKINCLFNAEMSLVNWDSELKSEMEVNIIKSFNIIAQRFEQRLLLDENSLHMGDRVSSAQMLNYDLINIGNSLIATWPNYSGSLMKILSDAISRIFNIARSSVFAILLSMHNEKLGMPSPYVKELCSYLTVFRYHLSLFLTNDNNDELRNFLNYVIELFLVNSSLLRPVTINDLNFLSNDLQYITENSISEFNIKTDLLNIINSLINSYRCSPEELEKCEELPFWFTVQLLISQSDLTLLSPHTSVNWSLDYYSDWFIKQTNSSRLNFLLSFMHSYNSSVISSESTKYVENYPFIMNILQKQVTYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQM0</accession>
    <name>A0A0N4UQM0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3806</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000189">
        <property type="protein sequence ID" value="VDN53833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQM0"/>
    <dbReference type="WBParaSite" id="DME_0001031301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001031301-mRNA-1"/>
        <property type="gene ID" value="DME_0001031301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820373at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288:SF2">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288">
        <property type="entry name" value="PROTEIN CBG16535-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001031301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17023" checksum="4609D140D4F28C65" modified="2015-12-09" version="1">MKLLVVRDQSSKILGHRWLNSQISFYIGVVQLIICIWAMAQHIYSLKRFNKILFCDFINGTQPSLLVSVDMIIFDIGLFHALWGIDNCVAQYLDGGYGRFGWCICHITAFIICLPFAFVARPRPYSLWPLLIQVSFNMESGKKCSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQY4</accession>
    <name>A0A0N4UQY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase_M16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3904</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000213">
        <property type="protein sequence ID" value="VDN53931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQY4"/>
    <dbReference type="STRING" id="318479.A0A0N4UQY4"/>
    <dbReference type="WBParaSite" id="DME_0001044801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001044801-mRNA-1"/>
        <property type="gene ID" value="DME_0001044801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001044801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32419" checksum="8DE86775F4CCDB0C" modified="2015-12-09" version="1">MVVAAVGVDHDLLVSLSESLFDPSKAIWASDSSIVPSNIPLIDNSVAQYVGGEKLVEKDLSNMALGPSPFPNLAHLVIGFESCGFKDDDFVAFCVLQSLMGGGGSFSAGGPGKGMYTRLYVDVLNRYPWMYSATAFNLSYADSGIFYIQASSDPSKVKIFQIADTASVIAEQFLLLLKGVVTKEELNRAKTQLKSQLMMNLEVRPVMFEDLSRQVLGHGLRRKPSEYVAKIDAVTSNDLLRISERMLSKRPSIVGYGDLKKFPDYKRFYEVFAKRSISEMKKRSFFGFDSPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR63</accession>
    <name>A0A0N4UR63_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3969</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000234">
        <property type="protein sequence ID" value="VDN53996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR63"/>
    <dbReference type="STRING" id="318479.A0A0N4UR63"/>
    <dbReference type="WBParaSite" id="DME_0001053501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001053501-mRNA-1"/>
        <property type="gene ID" value="DME_0001053501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR DMSR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001053501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20804" checksum="510EBD2D84FFA021" modified="2015-12-09" version="1">MAFWISGTIFKLIPCLLLTLLVWLLKRILDDVKEKRKRLIQGTNSSTKMRFVSLLLSLLYYFYFSGSVTDCRNERTDRTTRMLLIIVVVFLITEMPQGVMAVLSGMFSEEFRRHIYNNLGDILDLLSLCNACTTFIIYCSMSTQFRNVSDDSCDFRKFLKKYFTYCYYYISIHPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URG7</accession>
    <name>A0A0N4URG7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phospholipase A(2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10941</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001287">
        <property type="protein sequence ID" value="VDN60968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URG7"/>
    <dbReference type="STRING" id="318479.A0A0N4URG7"/>
    <dbReference type="WBParaSite" id="DME_0001064801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001064801-mRNA-1"/>
        <property type="gene ID" value="DME_0001064801"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="CAP"/>
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        <property type="entry name" value="Phospholipase A2 domain"/>
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        <property type="entry name" value="PLA2"/>
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        <property type="entry name" value="PLA2_Asp_AS"/>
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        <property type="entry name" value="PLA2_histidine"/>
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        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF107">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="Phospholip_A2_1"/>
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    </dbReference>
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        <property type="entry name" value="PHPHLIPASEA2"/>
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        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
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        <location>
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        <ligand>
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    </evidence>
    <sequence length="536" mass="60308" checksum="F5D77AE1509D7F2C" modified="2015-12-09" version="1">MVMCSFSSTLYPFIPYGCYCGFGGYGTPMDEIDKCCQTHDNCYGDALAKCYNITSLLYLWPYSWSCPKTAEGAVQTKTGNSPICKNSYRNPCGQALCECDQKIVECWANVSTTPPSERLECIEPKSNDKVDLSAYRRKALDAMNKFRAQLVSGNIATASGKLPRGREIWNDTLEDLAKKKVDECNFKLTQTNSQNNGEATHVSFDIKDEPIEDAISEWTKRVEQFYNSTSVSTSRIGSLDDFVQIASGLTVQVGCATNDICQVDYSSMQDYGTYYDNYDDYKTDERPTVQYTVCKFWPSGFMFKKLYKKGKQCKVGWPCRRRNSVCNKDGLCETEKTEKCDGENVPLKKSALDAMNKFRIQLAAGKIPAKNGKFPMGKEIYKLKWNCTLQALAEQKVQECDYSPAYTDSQGIGEAQHVPYDPPKYAVKEGLKEWMKRLKGKRNVTLLTSDYTSLLDDFVQVASGSTTDVGCATNSKCTYDYGDGDVEKIHYTVCKFWPSAKTFPILYEEGEQCELGWPCALPNSVCNKNKLCVRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URX4</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">DME_LOCUS4204</name>
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        <name type="scientific">Dracunculus medinensis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="38"/>
        </location>
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            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN54231.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001080601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10230" checksum="2AFD7641D085B067" modified="2015-12-09" version="1">MSADPVKPILATKHYSALERRLYKIMLAIDECVKQQKNGIKDVVMAEYHSDEILENAMDFLANDGENEETKGEKNTDFNNLETNLKLQR</sequence>
</entry>
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    <accession>A0A0N4US76</accession>
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        <submittedName>
            <fullName evidence="4">Protamine-2</fullName>
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        <name evidence="1" type="ORF">DME_LOCUS4300</name>
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        <name type="scientific">Dracunculus medinensis</name>
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        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Pathogen Informatics"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDN54327.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001090801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18809" checksum="7E97A7EE23922D72" modified="2015-12-09" version="1">MRLIHSCSRLRPRCRCSRLRPRCRCSHRCPRCCYSHRRPHCCYSRRRPRCCCSRRRPRCCCSRRRRRHLDKADEGDDEPLQLKKNVRSKAKACTILLKIVSPKNINQIVTNLVIGINPTANITVGKFFCLRRFFIARYLNSGFAILAKQLKSYIKHVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2N1</accession>
    <name>A0A158Q2N1_DRAME</name>
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        <submittedName>
            <fullName evidence="13">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">DME_LOCUS4843</name>
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    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Dracunculoidea</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A158Q2N1"/>
    <dbReference type="WBParaSite" id="DME_0000048301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000048301-mRNA-1"/>
        <property type="gene ID" value="DME_0000048301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342730at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="173"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="732"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000048301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112123" checksum="9B53558E8AF13CB5" modified="2016-06-08" version="1">MAIKNNSSIPLIDDHNDKNIKAKFCLTPNNSYKSLSDEKLDEINHVNASNDLSSFLEFNSKMFSDDSICPYCNKEYRTPKVLHCLHSMCEDCIIAQLDGREDSDKNRTILSDNLWSEEELEQSNIQRRVTPPGVIKCPECRQESHIGNDVRFVSLILPDYLRSYDIEKKKYANEMRKCRSCKSEPEAVAVCVDCKCDLCSGCVDAHSIMRAFEHHRVLTYRQLAKDPSQLPRGPVMCLQHPTIPYTLYCLKCDKIICTQCEIDSHSDFCHDISAADEKLCQIFKNELEEIVKNVSGKMLACSEQCNSIPERLRTLHNNYEVMLSQIDEAFADYARALDEVKENILKILLQCRDDTESSLNEMSDKGDIVTSRISDAIKFATRLMNEATSVELIASQKLAKQQLQSLQHTLPNNIISTELAFIRPSYSRFVEDLRKIVGSVKCQEPNVLQSPVRSVTPNSITKLNSNVAINSVLQSRSSESTPTFLDSCRQLELNQKSITPFVSSNSSAFSTYVNSFGLNPTSINSPGAIGMERRHKSGSISKHSSTAEFNSGWPPSSNPPASSPTPHNGYGKSTNQDNSCDYVWPPHSNPPPAESRGVGNVMPPSALSSMLPISSLTSSSKLNDPWMVASSSIITPGVIGQQAVSPYSIATNPLRSQSTMDNLIEQGLQSLNNIFDATLHNLAPSITSISQQCIAPDLQLKPVIGERFLPIVPPSRNTALSNGQLTEGLIVVSQTGGSGCSPGAFNQPHGFALGPDDEIVIADTLNNRIQILSKNGHFLKEFGAFGHEDGCLHNPKKVMPVRLFIKGPTSVDAYMVVDKKNGNARLQLFTRNGEFIRRIANPPAQFEYVAALTTNEMGYIILLSNNAYLYIFDLDMNLETHVIHFTSCSPALLEPSDVLALGNQYYVTDFKQHCVVVLDSLGNKLRLIGCGHTPYPIGICARSSDEIFVANSHMNHFQISLFSRNGIRQRILECTQMKVTRCVGLAINKDGLIVSVSKTCNTVFFFNTVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2P4</accession>
    <name>A0A158Q2P4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4933</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2P4"/>
    <dbReference type="STRING" id="318479.A0A158Q2P4"/>
    <dbReference type="WBParaSite" id="DME_0000057301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000057301-mRNA-1"/>
        <property type="gene ID" value="DME_0000057301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF86">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000057301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="973" mass="111830" checksum="B9F5BA3DBD404BBD" modified="2016-06-08" version="1">MLQRIGNQTDNILHFDEPITKEIPNDFLGRVKYYYDFYNLRSIAPFILLVLYSLLGATVFYWIEYDYEQELFRRETLVLESLRNETFYRLKSIMTDGISSERTKLYNSRDILVWYERQLGRMKSSSNLKWDMWGALYYVGTIFTTIGYGNIAPRTTGGQLLSIIYAMIGIPLVLAILNQFGKTLTRLASHLWLRNQIDLEEGTLPLRNDEYNHYQLDSANTNNKDENKDEDEIIESRTIPVWLAFLICIAWICLCAGLFCIWETQWSYFTSLYFFFISLSTIGLGDVVPDHPHMLILMFWLVIIGLSIVSMLLSVIQIKIEEWLYNLMIRMQKEYQRALECGDPIERKAILQKLMKKQPWLLRNMVPHLISENQAAQFNRQVENLEKSVRNTNNKNIQTEVPTSSKKSMEAQVDDDLDNSDTNGYCTAIELVDENLQTSAQTSPVVLNEGITLLKRTPEMLAEYRTQPFQLADDHADSISEVTSIPMDLTNFDQYELDRALIDRSQQFHISMDNCGIQTDNFSMNGCGVQTDIAQFQVEEIMLKLQELQNQAGYKPLVKDQSVDVSLEAFALECIKQQPEIVDSDICASAELFQRPALALIQREIQDNENSEQVTKYTQYDITPLIVDISICTDILENDMVERGTGTEGCILMSSSIETDPWMSQLQMPECSRAVQTQFNYYELLRHVSCSYYTVFLAILNFPNYLNYRSLSGRVPQVTQRSPCLDAKVFCDVQTQTMLELSDFLFDARNDQGVLKSSVSTMSLHGSELSLAPIVRKDLIIQTDDSYLKIARRLDQMRSNRTDSLHICVAKPLNSFNNSKKWKHDNNRLICDRPSERRGYIIDPPIRKRKSFKSSFDRRTSNMPPNRVTFSIVEEELKAEASALLLRRSDEAGPSSGSANQSRSDENSKAVRISLQGKKGKEHLAWKTSLTPSNIPWGKVSDYIKYHEMGIHSPGTPQGRRASNITIIDMRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2V8</accession>
    <name>A0A158Q2V8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cation_ATPase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5288</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2V8"/>
    <dbReference type="STRING" id="318479.A0A158Q2V8"/>
    <dbReference type="WBParaSite" id="DME_0000092801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000092801-mRNA-1"/>
        <property type="gene ID" value="DME_0000092801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="970"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000092801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118199" checksum="83523B82157B6AC1" modified="2016-06-08" version="1">MNISECEWFNECFFQDINFDSEFFEHILTLEQLNDYSPLSRICAEDPLKSKGLTKEEAISRSITNGRNIISPVSRQDSLKKFFKQCLNTFRMFLLIAAVACFIIYGLDPKRTLELGLAVFLLIVYITLSIVSYWQENKAFKQVRGFQSMIPTTCVVIRSNERMQINAAQIVFGDVVCLSPGTRVPADLRLIYTNELKLDTSWVTGEVEPLEFHSKEVKKGVSVLDAQNIALNGCQCVHGNGIGIVIRTGNQSIMGKLTTTMSQDKGRPTKLDLDHRSFVRFINLLAIIMGVTTFLFGLTVNRFQHIIRTFVNGFLVIVVANVPQGLSITLGAALIIIARRLSKMNLYMKQLDVADTLGTITVLMCDKTGIFTSNDKTVTDLWFNLEFHKGNKLIFLFRFQCAYTMEKMRITGIFASEKWKEPYDVLPTSGAANDQLSILLTVMSVCNKAQIESIGSGSLAQWSQLSQRFLDPVKIKPTEENVGSGGGDFFTIHRGQMLDLRAALQYKHITGNPSESALLKFAESITSVQQIRKKYDILMEIPFTGQRRFQAVVARMKSDSVLEDEEKYNLLYIFVKGAPEELILQCSRIAVSGGDEAYDKFANEGHSCIAFAFSELDSVKCDNFDMKWETLHDFDLCFLGMAAKLEALRDNIAKSLFNIKSAGIKCFMVTGDHPATAATVAKQFGLIKTTENGVDKQSDLKNSVIHGEILSKLTPQEWDTILMQQSVVFARTTPEQKLVIVKECQRRGEVVAVTGDGIKDAPALKKADVGIAIDAIGSVFAKEASDMILIHSDIKTIEKGIEEGRLLYGNLKKTIAYTLAHLLPELYAILSIDLVTEIPPSIAMTYEPAERDIMKIKPRKATSKLVSNSLLVYSYLIAGNIIAVGCVLAYLSVFWRYDIPIRDLLFSNDNHWHPDALNLTTSNGLLFTASMQVTIYQQATAAWHITLVMSQVLHFWTCTTRRTSIFRHGFNNLNAIFAVAIEILLLIIFIYTPAIQQWLNVAHPPAFLWLFAPAVGIALFVYNEVMNSWISLNGVKGESSALSSKTWTHYRTIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3C0</accession>
    <name>A0A158Q3C0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6464</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3C0"/>
    <dbReference type="STRING" id="318479.A0A158Q3C0"/>
    <dbReference type="WBParaSite" id="DME_0000210401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000210401-mRNA-1"/>
        <property type="gene ID" value="DME_0000210401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000210401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50341" checksum="79A3E6DBD7230C12" modified="2016-06-08" version="1">MYATAAGTEPSTNLKEVLAKKIVSHNKKVLEFRKEHDQTVLQNVNIGMIYGGMRTLKSMICETSVLDPEEGIRFRGYSIPDCQRLLPHAPGGEEPLPEGIWWLLCTGDIPNEKQTTAISKEWAKRGDLPEHVERMLVNFPSTLHPMAQFIAAIAALHSESKFAKAYHRGVHKSTYWEYVYEDSMDLLAKLTTVAAIIYRNLYRDGKSFGTINADKDWSANFVSMLGYDKPEFIECMRMYLTIHCDHEGGNVSAHTSHLVGSALADPYLSFSAAMAGLAGPLHGLANQEVLIFLSKIVKELGDKYTEKDLSEWVWNHLKSGQVVPGYGHAVLRKTDPRYTCLREFALKYLPDNKLFHLVSTLYKITPDILLKQGKAKNPWPNVDAHSGVVLQHFGMTEMGFYTVLFGVSRAIGCLSQMIWSRAMGLPIERPKSHSTDGLIELAKKTSKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3G6</accession>
    <name>A0A158Q3G6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase-activating Rap/Ran-GAP domain-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6714</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3G6"/>
    <dbReference type="STRING" id="318479.A0A158Q3G6"/>
    <dbReference type="WBParaSite" id="DME_0000235401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000235401-mRNA-1"/>
        <property type="gene ID" value="DME_0000235401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845589at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF62">
        <property type="entry name" value="GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="159"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="3">
        <location>
            <begin position="449"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000235401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="896" mass="102526" checksum="D240AF56DF15EEF5" modified="2016-06-08" version="1">MNRLSYRGSIHHNSYYKSIGLINPSQSATKLRGAKQFRLEPFYDLQYDSSTPSISPVIVENPQEETRWYWKYFLGNEHQNFAGIEPSTKLPFFISIMLEDTVCRAILWTSQGPRRLCFPASIGSNKILTAKTILQQFPGLEDYSRSLKEIADIKIQRELVILEDQEGGVNCKFGVIYALNFQTSDTQMLSNEHGDEDFEQFLKILGQRIELQDWGSYRGGLDVTTNSTGRESIYTVFAGHEIMFHVSTMLPYSNENFQQIERKRHVGNDIVNIVFEAGGDPKIINFLPTMMKSHFTHVFAVVKYDKESDCYRLWVFSEESVPVFGPTLSYPNTFHDLQLFREFLLTKLINAEKASLQANAFVEKRRKTLDTLLKDMYIEHLKESTKTFHKVTDIVIKRLLSPMKKEMKDRIDFCKYGELIKLEKMLCGDVSDAVQAPWEPAIISENILSWNVIGSDGWGAKSVVLATEDTGVVYISNGLSVPIIEATAQVMQIAIQEHFGLFLARIDKGKESSLAALTLVDLRIAIQDGNLILKKDFLDHRIPSSKGCHLFGTSDGHGLRLNIVMCISKNLTLLRWAFGPLGRIQVGTDIKNNFTLLKCLHLTEEAVAISVFERSRGCGSVRAVALTRSSLAIADFGNESIEYLDWKIPRSPITGLYGECTAGYDEIILSYQNMTLKIDYFEDGTYNLEETFWSSSLQQFVYRFPFVVGFGTDLIEVRLSINGNLLYSKYMPSVKVLSIKADIIFATEHTENFGDQNCVLNNQLQEKKLQHSSFRKKEKKDAKEREETFTNKKWKLCRISEAALKMEDKERISNNFDILQPQTFRNLRNKSERRPPTCREDEASQKWPNKVMERTKNYGNPLFNDHSMPNSPFIKILNPFSDENPVKSQVDQEKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3S6</accession>
    <name>A0A158Q3S6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7238</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3S6"/>
    <dbReference type="STRING" id="318479.A0A158Q3S6"/>
    <dbReference type="WBParaSite" id="DME_0000307901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000307901-mRNA-1"/>
        <property type="gene ID" value="DME_0000307901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="6">
        <location>
            <begin position="1473"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="1744"/>
            <end position="2016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000307901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2032" mass="230552" checksum="37CF630FA5D641B4" modified="2016-06-08" version="1">MNGCDDFTFQNLQCSAICLAKLGEVSLEKVKKSLLNDIQIAEKGILNHNIRSRLLAVGIYLIYSDGKYIDELLPFLVQSLLVLPKMKWVDDGILNLRDKIPIQEQFSFCFNTVLCDIAAHFPDRRDTVIAAQLNLLVYTTSAISDICQEEKPTIQVKANLMKLICFVIGLVRCFGRFSDDKCHPLISMIFPIPFKINETDMTELCDSTSVRRLNSLQLTTDSGNWFLSESKMGNNDHMKYQYMYSKLGSSFVISSDFRDWKLKIKCGELDALFDTIQVLLRSSMLASMDVHATDVFMSGSVKRFPYKTISECLSFVCLTMLRDSVAAYDILDPNRSLREKFAKEIKVFVTEILKRSQGELYSHKKIDDEKAQGGKEFVVNKTKLLVLAGSACLQLIVWAALDEMDAEILSHIISESLWMSRGYRYILASLPLLVMALEAFGSMAEKFPMMATTSTIPTLTRFLLEPSNILVKLADDQLNAEKRFAIVDDEHDDSNPVRRRHGLENLRRAAINSLCRSSILVPENAILTLAGIGTALVDVENVPQLVFNVFRQRTSYPSLSLDALIISSLANLWIAGAREIYDSIWLLFTKITIESSNRAYSSDSVDRSEQRYAHLSLAVDTALAKMAENTTDENDKQTLLFRLLELFVQLGLESKKVGEKVTKAVIKLSTGAGNLGVLIPKIASLLHRMQPITCPSPKLRNLFRDFWFHCTILGFDVAYSGLWPEDWYEAACVIATKSPVLTPQESLRAELVANAAIKNDAVTLNELHEIRNTVVGEIQPSVDVVAFINKMEFAHCIYLLSVFRMEKMRVCHSTEQDAVHSIFKYLEDRSIRKDKSGMWSCLLAATTVIFSEYLSAAKNIRMSGLLEQHLEYHVQYLLVMFNHTLKEIRRCADACLSKLIGHFPQLLWNGNVLITALQLLEALSHNLETDPDCKITILNIPKLHWSIRLQDSFDQRKIVVRDFSMRCEQILQQAMKWAPGSTRSHLVQHIASAYCAGSTSLQLTIETLRKGVDGEIDPGASLYLSSLHLRSLSLGQVNGMLSLKKSINPVNAEEELIDELELTLKCACKEKDEGAITDAVMKLSALFIILTDTNFRLLHVIVFIPLLSFTATTMRLCVMCWNWILVVRENIHLCFLREMASCWNAVLRKNFGLFKPEGTVISPLSVHHVQRSKAPMVDVHSIWVDFLCERVDIAKFSSREQLDILEIMFIQSLPLTVGRTCLHVNDSSSEIFGLSNLLDNAMITRNIQAVGVRFRLLNSALSMVQGDSFPGSSSQNLLRQRIYATCLDYFTIAPQIPTQETLQLKQDVKQLILFWNTLFSDVKYIKKSVTSAIDTDSQFASLYQTITDNYKPSTTYNTVNKADAQTWHALTHATSNWVTMVSSQNKIATLPKDFWTNESRPRDPSIEVDRQFRFFNKRRNLILLFIVCFDADEIERLSVWLNPLGEAMEEGEAVIDQWRRTTFSDPRTEQKRMKENIKLAWEICPDLAVHMPARFRAYVNCQSEVHDLIIRSPEVVSHIPEALPLLLADGIILEEKTEDLKSLNHILTWATCSPVVALSLVSARQYPIHPITVQYAVRTLRLYPPDVLLLYIPQLVQAIRYDGMGYVAELIIWLAGHSQLLAHQLLWNMQANLYRDEESKEKDIISQLEGAARSFFEKEFDLFKRITDISGKIKPYPKGEARKAACLKAVADVRLDSITYLPSNPEAIILDIDHSSATPMQSAAKAPFLVRFKVRQCGVQELERIGLAAYQKGNSRNDFDLRTLARSDDTNVCWQAAIFKVGDDVRQDMLALQLMRLMKNIFDAIGLDVRLFPYRVVATSPGCGIIECVPNSKSRDQLGRQTDFGLYEYFLTKYGDESTETLQSARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDTKGHIVHIDFGFMFESSPGGNLGFEPDFKLSQEMVGIMGGKMEAPPFRLFASLCVQAYLAIRPYQKEFIALVSLMLDTRLPCFRGKTIQQFRERFAPTASDREAAKYMMQIIRSCFLNVRSKMYDQLQYIQNEIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3U6</accession>
    <name>A0A158Q3U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7386</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3U6"/>
    <dbReference type="WBParaSite" id="DME_0000322701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000322701-mRNA-1"/>
        <property type="gene ID" value="DME_0000322701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851235at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000322701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35393" checksum="3BD59B27D7015300" modified="2016-06-08" version="1">MDLYDNDTNDYDDDGGIITTRSFIFVIITQIIIDIMSISLNTIVLVVGLFRITGSTLPIWARSMHQILCSFMVPPMSVALVPISVDRYLKVCRKRTIVMKVKPPIPLICFIIDSIPIISLLICKTIDVADRITNIIYTVIIPVGSLLIVFGCNMALFITLSKHVTIVAKLDNRRRMNETQQLARATCIQAITPLFIQLPSLLGIFSIVGASVDQTIVVWHLANLIWFMILLNPLVDALVTAFVVKAYRNEIRKIFETNLLKIFRNQESKRNNGCKNITRGSLVTTGNKSENKSSLQCVDLKVLTYVNGDNEETFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3V1</accession>
    <name>A0A158Q3V1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DME_LOCUS7403</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3V1"/>
    <dbReference type="STRING" id="318479.A0A158Q3V1"/>
    <dbReference type="WBParaSite" id="DME_0000324401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000324401-mRNA-1"/>
        <property type="gene ID" value="DME_0000324401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="379"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDN57430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="DME_0000324401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67993" checksum="11DE0284F12F29DF" modified="2016-06-08" version="1">MADIYHAGSGVSKGFPQAPYGYPMHCNMSRAFQEMTDDERKCLEERKYWCFLLSSVFLGNLQNFSIVTFCVSMLLVVVWRIVTHLFCQRRERDEIETIYEQQNGKHGLLKNEIDGFAFKQEEVQIGWMTEAKDWAGELISGQSMTGRILVVLVFILSIGSLIIYFYDASHPNFQVETCVSWSESPSQQIDLGFNIFFLIYFFIRFIAASDKVWFLLEVYSFIDYFTIPPSFVAIYLERNWLGLRFLRALRLMTVPDILQYLNVLKTSSSIRLTQLLSIFISVCLTGAGFIHVLENSGDPFKNFANTHRITYWDCVYFLLVTMSTVGYGDIYCTTFLGRLFMVFFILGGLAMFASYVPEIADLIGSRQKYGGEYKGEHGKKHIVVCGYITYESVSHFLQDFLHEDREDVDVEVVFLHRVPPDLELEGLFKRHFTKVEFFTGTVMDSIDLSRVKVDEADACLVLANKYSSDPDAEDAANIMRVISIKNYSADIRVIVQLMQYHNKAYLLNIPSWDWRRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSRQTPDWLNLYLCGAGMEMYTDTLSHGFVGMTFPEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Z4</accession>
    <name>A0A158Q3Z4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7645</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 14"/>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Z4"/>
    <dbReference type="STRING" id="318479.A0A158Q3Z4"/>
    <dbReference type="WBParaSite" id="DME_0000364001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000364001-mRNA-1"/>
        <property type="gene ID" value="DME_0000364001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF30">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000364001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25326" checksum="6180D9DCDF09B8DB" modified="2016-06-08" version="1">MANTLMHISQLHWIVVEDNNSKIKAVEKLLNRTGLPHTYICAKTIPGYPSRGWYQRSRALEYLRKNTDQITLNKSNSVVYFGDDDNSYDIRLFRDYIRRVRKVGIWAVALAGNTAIEMPDVHQGTVVGWKVLWNKKRKFATDMAGFAIALNIILKSTATFGTSCDQGLGAPETCFLEDLGLGITDLEPFGFDQDDKEVFVWHTKTVPVKYNKRIIDSGGFFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4T0</accession>
    <name>A0A158Q4T0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS686</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4T0"/>
    <dbReference type="STRING" id="318479.A0A158Q4T0"/>
    <dbReference type="WBParaSite" id="DME_0000564101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000564101-mRNA-1"/>
        <property type="gene ID" value="DME_0000564101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="338"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000564101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59452" checksum="F2F7E0E5BC3F08B2" modified="2016-06-08" version="1">MRPNQAGFRSGCRCTNQIFTLKRVLEHRFKYLQPTVTCFIDFAAAFDSIDKKALWRVMECDDVPEKTIQLIKAFYEQRRLRWLGHVLCRPPQELSHISLLTKPCDGKRGGPIKTWTDTPMDDFISVKSEEIEQKDKWSVIFPNLFQNGEAVIDSTNVNGELYENLAEIGPVRAEDLVENDDIDLAYQKSREAGVLHQYFGPRPILSETEQALAVKFPGLPTRPKEAVEFLQQHGILPLECKCQQYGHSMRLCFKRDIFWRDSHSTCNRMVTIRKGTWCSDTCLPFVTIIRFIYGWAHELTSLEWCRRELGLSAKTIVKWNKQMREVCVEAMRQQKNKKIGGRNKIVEIDESHFTNHKRNGNRELRQLWVFGGFCRETRECFVVQAPNRNVVTLMQIIGENVEDGSTIVSECWRRFKEIEVKQAGFEQFQSIHNYNFIDSGNEEYSENMDKLWGFVKWRSHKQRGTARHYFESYLIEFMWRNRLGRRNPFDAILTSIKEHWPPKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5C5</accession>
    <name>A0A158Q5C5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS9798</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5C5"/>
    <dbReference type="STRING" id="318479.A0A158Q5C5"/>
    <dbReference type="WBParaSite" id="DME_0000699901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000699901-mRNA-1"/>
        <property type="gene ID" value="DME_0000699901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05034">
        <property type="entry name" value="PTKc_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000399">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000115">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033730801" description="Tyrosine-protein kinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="254"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000699901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60185" checksum="FA527F5A20B5DEB1" modified="2016-06-08" version="1">MSFFFLLVLVTLVFSTSGFIPEFILSQMEKAEQLAKLLIVANPRLRNPERPKTFANLFRSSDLSAGKDVLIALYAYESRADGDLSFRKGEIMYLLDQSNSDWWYVRHSKGGTGYVPRNFVAKQLTIESEEWYAGRIARNRAERLVLASNLPKGTFLIREREADTREYALTIRDSDDQRGGTVKHYKIKRLDGDGGFFITTRRTFATLRDLVSYYSEVADGLCCQLSFPAPRIAPTRPDLSHDTQQNWEIPRNQLQLKRKLGDGNFGDVWYGKWRGMVEVAIKTMKPGTMSPEAFLGEAQIMKQCDHPNLVKLYAVCTKEEPFYIITEYMANGSLLQYLRNEGNTLTLQALIDMCAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIITKGQVPYPGMHNREVIEQVELGYRMPMPRSCPEQVYTEVMLKCWDKVPDRRPTFDHLFHFFDDYFVSSQPNYVPPSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6L0</accession>
    <name>A0A158Q6L0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000197">
        <property type="protein sequence ID" value="VDN53862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6L0"/>
    <dbReference type="WBParaSite" id="DME_0001036501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001036501-mRNA-1"/>
        <property type="gene ID" value="DME_0001036501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5828686at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001036501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52119" checksum="26AEAD20F2614915" modified="2016-06-08" version="1">MIIFTFAQIPPCINNVTEHRLRCLWHVLCCPPLESHISLLAKPCDEWHQKRGDPIKTWTDTVRKDFERIGGPGIYGLRRWKKECFWLIESQLKLCWASIDKPSSTKYCKLIGMRQYSLTKIIVPQHESLQLSLQPLNRNFRTNVRVIIQEIIVRTDECNNRPLSKNSTFTKAILSEPRFKNITAKKTNSTLIEQNTKAFSDITNENKQPASVLEDIFGRDFASFLQADSDYSVDIESETTKGNNLNIFTKSFLVGESRIIEKTDATLFTGTPPETFEQYTLPVPTQISLVDAVNPLFCNTAGGCLFDRSLFEGRYFLQAFVRPGNLAVLEANTHMSESHRIIFDALEYEEGQKLSGCCNVPRQQPLGGLICPFSTNMEKTSAEWFSANFVCPAEFLFLPALTTSSWAGSTGYKGPTLLLKRNGSHCSFCFFQRLSPYVAGPAISESFLTISVQVLIGPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PT38</accession>
    <name>A0A3P7PT38_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PT38"/>
    <dbReference type="STRING" id="318479.A0A3P7PT38"/>
    <dbReference type="OrthoDB" id="6360013at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="685" mass="78411" checksum="995D1580575D525B" modified="2019-02-13" version="1">MVKEILFEPWSFRGILKSPQQIVIDGATIREIPKNAFSGLSNMEHFWFRNSTIGFIAQNSFENISKIEYLYFRDTVIFSLDQISIEVCDNSGYMRDIAHLFFRSSIYIGSSGHSVFAYSYISELIFEDANITSDEQIFSDFQTNRLKFINSRWKNIINGKKQTFVFHINEIFLLNCILNSFILTSGNVSSIKIHESEVQEIRGNSRNSQNHIKFIEFHQSVIKRIKSESFLNAKHIARFSIAQSRIGVIEARSIQTSKIAQLNIKSTMIDKIHHNAMQNNSIHSLLLLNSTINKISSKILAKSRINTIVIDNVYMGNLKKYCLAEIMGENLSIVNSRIQQIREMPFLKSQFDNITMLANVITKGVLRDIFTNLSTNFLLIMRNYFPCDPHDCETNSLILIKSKKDLRWRFEDNQCIENKDICVKDRISKFNGLTCRLSRQIAECVCNINEPVNLPQLDVSVLFIEGCFQLYLEHKTLLASTPLVALHIHGVELLFIKGVSQSLRTIILCNSRISIHQNAFYGSQIDRLEINSSSINVIERASFNDGFIKKILIHDSEIMDSQSGAFRNFTVNSFIAERTKIYNSIDIWQHFSYISIMESYIACPMPLLNVSSLCLKKNIIECECVEGDLDAKSNCGDGSSICNERKSPISPYECSIPRLCESAGPHSQDRYLIRIVLIFLYYGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QIV7</accession>
    <name>A0A3P7QIV7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QIV7"/>
    <dbReference type="STRING" id="318479.A0A3P7QIV7"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000355">
        <property type="entry name" value="Uncharacterized calcium-binding protein B0563.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="194" mass="22634" checksum="263CE934BC5E57A0" modified="2019-02-13" version="1">MPYFICLSQSFSQKFYYDHSSQRNSSSNSNLPLIKQKLAEYTNEELEEYRQVFNMFDTDGSGAIGIDELESAMKNFGLEAKRDELELIIEEVDQIGNHEIDFHEFCDVMKRMNAKKRSWNEIVRECFAVFDRSELGVVSKKDFAFVLRQYGGIQDNQVIDEIFAEVDVDGNGFIDYDEFAYMVRNYMTDDDICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QLS3</accession>
    <name>A0A3P7QLS3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QLS3"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF41">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31728" checksum="61D20A18CE625E6B" modified="2019-02-13" version="1">MGCPEVERNAVISNGISVVLNEDPNAPLVLLFGWAGCVDRYLAKYSEIYEKQRYSIVRFTADVRKIRSFASYRDFALEIYEKVVERSTTSVIICHLFSMNGCLVFCALWDLIDTVVDNDFIKSKFRGIIFDSSPANVNAWQTATAFSIVHMPPSKYGRSFREIYRIFLASYFSIYRAILWLRSQWESNVYEHNIAYYRLLAISDLPKNQLFIFSSIDGICSANSIAEFARIQEERGAQICKIIFSDTPHCQHLRFHPDEYEHACLNFIKSIVQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T083</accession>
    <name>A0A3P7T083_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T083"/>
    <dbReference type="STRING" id="318479.A0A3P7T083"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15880">
        <property type="entry name" value="SNARE_syntaxin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000022">
        <property type="entry name" value="Syntaxin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000001">
        <property type="entry name" value="Syntaxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF424">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="247" mass="28325" checksum="25891EC36E251A46" modified="2019-02-13" version="1">MSKSLFFIQVEEIRGSVELIASNVEEVKKKHSAILSNPVNDPKTKEELDELMASIKKTANKVRGKLKLIENSIEHDESSGMSSADLRIRKTQHATLSRKFVEVMTDYNKTQTDYRERCKGRIQRQLDIAGKQVDDQDLEEMIESGNPGVFTQGIITDTQQARQTLADIEARHNDIMKLESSIRELHDMFMDMAMLVESQGEMVDRIEYNVEHAKEFVDRAVADTKKAVQYQSKARRVCFSAYFVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U100</accession>
    <name>A0A0N4U100_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS4610</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U100"/>
    <dbReference type="STRING" id="318479.A0A0N4U100"/>
    <dbReference type="WBParaSite" id="DME_0000025001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000025001-mRNA-1"/>
        <property type="gene ID" value="DME_0000025001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="15">
        <location>
            <begin position="171"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN54637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000025001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39551" checksum="F825C2C8F203575E" modified="2015-12-09" version="1">MSYRRYNPLLDEWILISPNRIKRPWDGEITNSDSETANTKVSNSSSTKNPLAPGGIRSNGEITPNYTHTFVFPNDFPALNEGNFSVRAKGVCRVICYHPCSSMSMAKMKLNAIERIIDLWIEQFNELENRYDWIQIFENKGYMVGCSNAHPHGQLWASDFLPSQQSKMLSSQKYKERTGRIMLMDVVQHELEYQKRIVVENDEWLVIVPFWAIWPYETMILPKKHIASLNHINKQKCLLAILLKKLLVKYDNLFKCCFPFSMGWQSSPTGHYLNEDCSFWTLHAVYLPPLLRSAKIKKFIAGYELLCEPQRDLTPEMAAESLRKQSEQHYENDQSRSMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U132</accession>
    <name>A0A0N4U132_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4647</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U132"/>
    <dbReference type="STRING" id="318479.A0A0N4U132"/>
    <dbReference type="WBParaSite" id="DME_0000028701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000028701-mRNA-1"/>
        <property type="gene ID" value="DME_0000028701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF110">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR DMD-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000028701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25609" checksum="42F812A2F0E98D88" modified="2015-12-09" version="1">MNIEEILPELFGEKRIYYCQRCLNHGLDIKRKNHKADCIYRFCTCNDCQMVDRRRELNSRLLQIETTSPPSSITETTTDMHLILAQSASSPQSTKGKERRPNCQRCAQHFVQARLKGHKRCCPFRDCPCAKCQVVQERQKLMADQIKLRRKQKKQKTLDAIIDMDNANIPISTFINIRCMKCTQQLFGYQHLLSLVDPSMILDPALISTILAAYTNGNQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1H4</accession>
    <name>A0A0N4U1H4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane inner ear</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4818</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1H4"/>
    <dbReference type="STRING" id="318479.A0A0N4U1H4"/>
    <dbReference type="WBParaSite" id="DME_0000045801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000045801-mRNA-1"/>
        <property type="gene ID" value="DME_0000045801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6154284at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032006">
        <property type="entry name" value="TMIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28635">
        <property type="entry name" value="TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28635:SF1">
        <property type="entry name" value="TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16038">
        <property type="entry name" value="TMIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000045801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10714" checksum="C9C6EC32C4151900" modified="2015-12-09" version="1">MNSGESSIAALDRYIAPGLRLWMLIALVSGILLIMVVIVCCFMRIRIPRTKRQIDLIAAKRKMRKAKMPSVTSHQEIVYSGKNTGSNFNCNELIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1K5</accession>
    <name>A0A0N4U1K5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4853</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1K5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1K5"/>
    <dbReference type="WBParaSite" id="DME_0000049301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000049301-mRNA-1"/>
        <property type="gene ID" value="DME_0000049301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000049301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14236" checksum="5375D6F3A59B0631" modified="2015-12-09" version="1">MANIARSINAYLRRSSAKDWRNYFLSTHFWGPVANWGIPIAAIADFKKSPEIISGPMTAALILYSSAFMRFAWLVKPRNLLLFVCHFTNCSAQTIQMMRFVNHNFLHLIENSAIKRATGTIKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2B7</accession>
    <name>A0A0N4U2B7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5169</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2B7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2B7"/>
    <dbReference type="WBParaSite" id="DME_0000080901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000080901-mRNA-1"/>
        <property type="gene ID" value="DME_0000080901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="249"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000080901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48671" checksum="AB245AE2AD69FAFA" modified="2015-12-09" version="1">MYISAQMEDPAKFMIDIGTGYFVEMSNEQAADYFKRKQQYLKKQMETIEKILPEKQQVRNIIMENLKKKIQLLCAHMPAVSELMVVNVMNFAALKLFLVQSWEHVLQLLDIRNKIFVQISCNLTEPTSARGNMGSVEVHVRMSPMAAPTYEDGKLGSKGIELMRVLEILLRDCGVIDLESLCIRKYKQIWSIRVDVHILDDDGSLIDCASVAVLTALVHFKRPDVNVLSDSVIIYGSSQKMPIPLNIYHLPICVSFGVYDDTQPAVLDPTDREEMCLKGTLIVAVNKRHEICTLHQTGNLVLNQDLIMQCVETAMQRAINVSELISSVITDDNLKSGLVSLNILSSHQCEPNELIAPAVKNHALIIGERDDKVLIEEDLIQIGSEDQELIEQIAEITVSQKILDQSYKGRTEMDDVNDLLDSIEENFANSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2D2</accession>
    <name>A0A0N4U2D2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5189</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2D2"/>
    <dbReference type="WBParaSite" id="DME_0000082901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000082901-mRNA-1"/>
        <property type="gene ID" value="DME_0000082901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875579at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000082901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12142" checksum="16875E233CD76863" modified="2015-12-09" version="1">MGIIEGIVPNWSENNFSDKDSSSSVLSIAIECDEELSEQGDLSPLAEIAESTSDEEACSSVTNSITAVGFHASTSTSCTTSTDRMSNGERIPRLSVGPYQQRPRPILNENSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2D7</accession>
    <name>A0A0N4U2D7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2D7"/>
    <dbReference type="WBParaSite" id="DME_0000083501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000083501-mRNA-1"/>
        <property type="gene ID" value="DME_0000083501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000083501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16038" checksum="23560D58D98CEBE8" modified="2015-12-09" version="1">MAVGCYEKTNLRLLNDDFTWGGDVINFGGEAQPVSSVTANATSINTNTSLWNLSNYCDTIAITTATDITNITNSVNTTIATTISTINTNDHFANHCFPRTATSPHKNSNLFWLNQFSTTELVRFFSNLFTITSIFISFIVHIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U335</accession>
    <name>A0A0N4U335_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5487</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U335"/>
    <dbReference type="STRING" id="318479.A0A0N4U335"/>
    <dbReference type="WBParaSite" id="DME_0000112701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000112701-mRNA-1"/>
        <property type="gene ID" value="DME_0000112701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5783007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000112701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12028" checksum="ED854D7CBC380F77" modified="2015-12-09" version="1">MYDKNGSPGRKNDRLDLKRQRPYGPEKTTDQALHIVKNINGDDENPIKERFKCRRNGCCDQHEWCRFWASVGECIANKDWMEKNCQLACASCSHSGKSFQVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3C4</accession>
    <name>A0A0N4U3C4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyaluronidase</fullName>
            <ecNumber evidence="7">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5583</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3C4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3C4"/>
    <dbReference type="WBParaSite" id="DME_0000122301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000122301-mRNA-1"/>
        <property type="gene ID" value="DME_0000122301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="10"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000122301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43536" checksum="13122AEA97374422" modified="2015-12-09" version="1">VIWNVPSRNCVKKNVTIPLEKYHILANSGNEFYGEHIVTLYETKFGLFPYFKNLSDPKSAVNGGIPQKINFRAHLRQVKWDIEKAIPNPSFSGLAILDIEEWRPLWSTNWGDKRLYRIESIKYVLRRYPQISRKSARKIAIIEFNKAAANIMISTIRVGIQTRPFAKWGFYGFPYCNYDAGSEGEYECSPIYQRINSRLNFILSKSKALYPSIYLYKKSEENENFRYIHAVLKEAKRVSSQFTPKKPIFAFTRVEYQPYENPTYYYSEFDLCNSLKQSSDLGLTGAIIWSTSYGMTISRCLDLSNYVINRLGPYMTTVIARAKICSNKNCLRHGQCVRDEQQCNSLTKYSCECDFGYRGDHCQYRYYLSWLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3H6</accession>
    <name>A0A0N4U3H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5641</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3H6"/>
    <dbReference type="WBParaSite" id="DME_0000128101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000128101-mRNA-1"/>
        <property type="gene ID" value="DME_0000128101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000128101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16727" checksum="1FAA60527F67FE79" modified="2015-12-09" version="1">MLRVESFSNSLRRQAAGSGAPASNESPAKISAHATKTCEDRDYRCFDLVASGGEMSCSATSYTTKFCPKTCVLCGSMDKKAGGKAIFPTIPIFTYGEEIEISLPQPNMKGLKALNYSAFAWDINNQQELHSEYGYIAMNSRTNEVALTTVMNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3K1</accession>
    <name>A0A0N4U3K1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS5668</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3K1"/>
    <dbReference type="STRING" id="318479.A0A0N4U3K1"/>
    <dbReference type="WBParaSite" id="DME_0000130801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000130801-mRNA-1"/>
        <property type="gene ID" value="DME_0000130801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000448">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
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            <begin position="135"/>
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        </location>
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            <begin position="315"/>
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        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="504"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="674"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="848"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="881"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="928"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1026"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1135"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1325"/>
            <end position="1349"/>
        </location>
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        <location>
            <begin position="95"/>
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        </location>
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            <begin position="473"/>
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        <location>
            <begin position="809"/>
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        <location>
            <begin position="1104"/>
            <end position="1359"/>
        </location>
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    <feature type="domain" description="Voltage-dependent L-type calcium channel IQ-associated" evidence="22">
        <location>
            <begin position="1369"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="21">
        <location>
            <begin position="1432"/>
            <end position="1481"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="714"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
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            <dbReference type="Pfam" id="PF16905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN55695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000130801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1486" mass="170682" checksum="9CEB5B3439233598" modified="2016-06-08" version="3">MKSNEVYQKVFASMMASSAEEDDHHADETRRTDLWQQTLQAAVAATSQSETAKKRQQQRKPLRPTNIVEKSERSLLCLTLSNPLRKACISIVEWRPFEWLILFMICANCIALAVYQPYPAQDSDTKNTILEQIEYLFIIVFTIECILKVIALGFLFHPGAYLRNAWNILDFIIVVIGLVSTALSRMNIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVMFVIIIYAIIGLELFCGKLHSTCLDPATGQLAQHTPSPCGFASSAFHCQPNGHYEGVQWICTSNTSWQGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWINQAEDIEPVNDDEQEDEQQFNGEEMDDEGEEKAEDSRMSWWNKKFKRLQKFNRRCRRGCRRLVKSQTFYWLVIILVLLNTLVLTSEHYKQEPWLDHFQTAANLFFVVLFSMEMILKMYSLGLTTYTTSQFNRFDCFVVISSIIEFVLVYFDLMQPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIMSLLLLLFLFIVIFALLGMQVFGGKFNFNPMTAKPRANFDTFIQALLTVFQILTGEDWNTVMYNGIASFGGVGSWGVLVSVYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEEQAEVEEEAAEDDYEDEKYDENGNEEVRDDSRIVVDEDEEGDDTMVSARPRRISDLAPTKQHKPIPKASSLFILSYTNPFRVFCNKIVNHSYFTNSVLVCILVSSAMLAAEDPLDAQSPRNTILNYFDYFFTTVFTVEITLKVVVFGLVLHKGSFCRNAFNLLDILVVAVSLVSFVLKSDAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFRCNDESKMTEQECRGEFLAYEDGDPMKPQRMRRDWTKNDFNFDNVVDAMDRGPVYNARQAVALFFITFIVVIAFFMMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRFQYRVWWFVTSQFFEYVIFIIILCNTTTLAMKHYPPDPGMDHILDVLNLIFTGVFALEALFKIIALNPKNYFGDRWNAFDFIIVLGSFIDIIYGKLSPGSNIISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQVFGKIALNDETHIHRNNNFHTFPAAVLVLFRSATGEAWQEIMLSCSDREEVKCDPASDEYKQNVDARCGVDFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEVNEQLRSAIRRIWKRTPQKMLDEVVPPAGMLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3N4</accession>
    <name>A0A0N4U3N4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5704</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3N4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3N4"/>
    <dbReference type="WBParaSite" id="DME_0000134401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000134401-mRNA-1"/>
        <property type="gene ID" value="DME_0000134401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000134401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36768" checksum="AE260D2B3A27923B" modified="2015-12-09" version="1">MLLHTNLFRQRKTELRGHVEFIEAALKNLESFGLHKDLETYKELLNIFPKGKMVPQNIFQRIFLHYPMQQICCVKLLDQMEWFGVQPDRELYDFVVNAFGDWNFATKKIKRMMYWMPKLKNTNKYLDRRHIEGKDLSRVQLAFIALKMMARDPGTSISYVKVSGVDVDENVRWLISAQSVSQKRLIEEIKPKTTIYIDGPKLVYVMDHQVEYVTMTMDPRLDFFDNFRKESDNNFENWHMTWEANRWSKRESTIHEQKDETILGLAVLGVANRAFATAWINHLQEAASLINDANVLFRIKEGLSLVINPSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U401</accession>
    <name>A0A0N4U401_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5840</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U401"/>
    <dbReference type="STRING" id="318479.A0A0N4U401"/>
    <dbReference type="WBParaSite" id="DME_0000148001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000148001-mRNA-1"/>
        <property type="gene ID" value="DME_0000148001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000148001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29476" checksum="2CDBAAB388177327" modified="2015-12-09" version="1">MAERGGFRGGFGSGGGDRGGAGRGGRGSGGERGGRGRGGRGRGRGARSGKENESSWTPVTKLGRLVKERKITSLEEIYLNSLPIKEFEIIDTLLFNLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDHNGHVGLGVKCSKEVATAIRGAIVVAKLSVIPVRRGYWGNKIGQPHTVPCKVTGKCGSVLVRLIPAPRGTGIVSAPVPKKLLQMAGVEDCYTSAVGQTATLGNFAKATYAAIQRTYSYLTPDLWKEHSLEKTPYQRHWDYLAASVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4P6</accession>
    <name>A0A0N4U4P6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS6126</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A0N4U4P6"/>
    <dbReference type="WBParaSite" id="DME_0000176601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000176601-mRNA-1"/>
        <property type="gene ID" value="DME_0000176601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21193">
        <property type="entry name" value="CH_beta_spectrin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21194">
        <property type="entry name" value="CH_beta_spectrin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="839"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="3678"/>
            <end position="3786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3795"/>
            <end position="3834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1305"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1918"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2649"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3065"/>
            <end position="3117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3313"/>
            <end position="3344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN56153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000176601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3912" mass="453152" checksum="A87D4FB4D4EF6C96" modified="2016-06-08" version="2">MKLNISEGISQRLYKHDSILAKVQVPQVNRSGYESPSNAHPEDYDEFTDPTLFFERNRIKQLQEERIHIQKKTFTKWCNSFLTRARMEILDLFIDVGDGVILMKLLEIISGEKLGKPNRGRMRVQKIENLNTSLDFLKRKRIQLENIGAEDILDRNERLILGLIWTIILRFQIDTISIPMDEESGERKHAKEALLLWCQRKTAGYANVKIENFTTSWRNGLAFNALIHAHRSDLIRYEELSPQDPIGNLNNAFDIAEKKLEITRLLDAEDVNVAHPDEKSIITYVSLYYHYFAKQKSEMTGARRVAKIVGNLMSSDQLQEDFEALCCDLLQWIQQTILILNARRFPNSLKGIQDELVRFKNYRTQEKPPKYKEKGDLEALFFTIQTKRKAMGRSPYLPPQGLLMHDVESAWGLLDHSENDRQLALTVELRRQERLEHMAHKFERKAALRDSWLKEMNSVLQDFDFGRTVAQVEAALKKQQAIAADILPQEDRFKSLSLMANELSHEKYHDYERIKMRERNILDKWSQLLAALASRRKALMSLNDLMQLLRDIDTLSSEMRFLETQFLNRDIGKHLVGIEDLLEKQEILEAQLNLQGDLLKNVTSQALTYIREKGEQYDVLQRKLDDASSIYESVVDLCRQRRMALHRARDLYRFIQDHEEEVNWLKEKEDLCLSVLNNRDLTATPQFRRIFKNLETEMQGHWQRSKGVIAAGEHLSSGQNKDDIKSRIVTLQNKWEQLRKTMEVVSRWLREAEQVHQYFHDANEAESWIREKMPLVKSDDYGRDEQASESLLLRHTRLEEEIHAYRADMIRLDEVAAELGNVEFVAGMGVQVEEQIEELIVPQIRMLFPFLSNHISTKKDEVLALVEKTNNDWWRVLKQDGVEGYVPANYCRVIDGETVRIAQTIRKSRRGSQESKNAIIQRQETISADYCKLCNLAQIRRRLLSDMIKLYKFLRECDQFESWAKETEGALADNAATENVPAFRKKFDKLESEIKSGGKSQIKRINDIANDLTNEGHSHCDEIRRRQEAANHLWNRIQNMQKIKQKQLETAERIATFNEYCEEARSWMQDKFDLLNQKVDPSDAKAVQALQKRYQNLGKDLKPLEDKIHYLQQLANEVKKEHPGEAAKIEAMVKELNVMHSELQKKAAARIEEAEQTQGHQMFDNAVKNLLVWIEKTRMALADNTRPVDVDSAENLLRKHYKLNDEIIGKKYEFGYVRDLGSRLLLKSISLTDVKDKLTKLDDAENSLITQWKEKERRLKDSLDVQLLNSEAEYIDAATKGHEAFLEFANLGDTVETTENLLKRHSDFEAKLAAQEDRLKAFSKNADMLIRRGHSESAFIEQRRNDVLARRTAVHVAAAKRRSKLEASLIAKDDSHKDIASLALKLLKHSAFEAELRSNSARLDQLNNDGKTLIAQQHYESRSIQRLLDHLNTEWEELCRAAKAKGEKLRQAEDQKGLNVVIDDAYLRLDEIQNALQSRDLGSDLRGVKDLIQKHAVIEKEMTMFETRITEIVEKAEHMVKNGHFDADSIKKSISNLDERYKSLELPLKERRFTLEESLKCHKLAFDIDCEMHWIAEKEPMAASDDTGRSLTEAKNMQKKHEQLEAEVNSRLPHVEATLKRGDILIKEKHYAHEQISAKCKQLSGAWAHLSQLIRRRQRLLDWALKEEQYLFDAAEVESWMNEKHATLCSEDYGQDEDAALKLLTKHKALQADMSAYKKWLDNLAVKCGELKNSLRSSKERFINRQLELEKEFDALSNAADDRRRQLENAVHLYQYLRESHDLEAWINEQLQIAMSEDYGQDYEHLKELQSRFEEFKQSVKTGSERFVHCESAANSLLKRNPPFARDILMRQEKLRAVWTLLLDYIESRDQKLEAAEELHRFNRDVAENQERIADKHAAIPSELGKDIKQVHSLWLKHEAFENQLGAMEQQLQALLEESARLKEAYPGGNAEHIAAQQTSLAEAWQDLQDATVCRRDALKAAYDLQRFYVNARDLIAWTEVIITDMQSEQAVHDLQGAEWLQKEHFRLQAEIEAREPEFARLAQRGQQMIAKEHYASSEIVEKLKQVENALGRVRNEWSMRSDWLAQVREWHAFQREAKQTLGAIAARQSTLRCAEVGGTVEDVENQTKKLETFRKALNILDDRVVALQKTAKHLISTRHMESAKIDQWTRQVDASLAQLCAEINVREGILTDSLKLARFISDVAEMENWIIEKQKRISLEADRQAKLSSIEDKVKRLQKHQAMEAELSANEPRVQQIRLQAKDLATRPTSDSHDINKKCNELLDKWNELVAMSKDQSSALEEARDLLNFNQLVERVLQWVKEKELLVNAAAMGRDMEHCHLLLEKLDGSKADASVDESSLVSANRLGDKLIAQGRSSQKVVQQQLLELNDAWKSLQGKLLRYRSQLRAALEVHAFNRDVDDTCDRIQEKLGLVTSDDLGKDLHGVEALIRKQEAIERDMGVIHEKLRVHDSDAQKLLSRNPPLREGNQLIASGELHRFFDAVRKAEARSVDMLTQINAHEEPESVVKADSLIANHIEKLAEIDGRQREMAELREWGTKLISEQPDHKGEIQRVLKRLQNIEHQLRQAWEAKNNALAKTRRRKLFTDQANRAEQWLTSKEAFLNQADLGESVDAVDILLKSHNDFEKTLVAQSDKIDVLRNSAEELMQNDIENRDEIEKRRDNVVARHAVLLDSCKRRHALLIESRKLHEFIDSCGELMTWISANIQLAYDESFLDQTNLRAKLQKHLVFDAELDANEGRIKTIVDVGEKLINEQHYASDRIALQISEIKGGWKELRRKSALKKRRLCEASEAYQLNRRIEDLERWLERVENDLSSEDHGKDYISVQMLIKKHDDLAAEIESRRDSVIEIVEKAREFEKQGYAAAQDSVQMAKTVEMRYNSLKKPCQIRRDNLRDAFAFYKWNSEAEEQIEWLGDKLRQLKSTDYGDTLHAVQSLTKKHSHLEEEVNTRQLSLSDVERQGLEMVKSYHFASEDIEKKVDELSSLVLCVKQLIQERTLKLADSLKSQQYYAEASEAEQWMRERLPLISNQDTGRDQAAADAHLRRHAILESDIENFYAEIDRLSKNTGEMIGNGHFDAANLTAKQVKLRQLYDELRTRCAQRRIQIVNVSRYCGFVRQIDDLYHWLNERLEITKQENYGRDLEECQKLVADFDQVVRELASAGERVATVQRTQEELLRSGHPFGASIRAKGTDLQQLWSLVNDAANERHLALQGAIQVHKFDQDADETLGWLEEKEALQVAMESENLDRADIPTLKQLMLKHDEFVHGVLAVEKQVNDLCKEAERLISLYPDTRQHLEVRRMEMEEQLKDVMNASKKTLEKLQQMQNLQSYFQEQRDLIAWIKKLQLSITSETLPNDVDSCHALMSRHMEYNSEIVGRQPTVDEFIRKGRSMISTQHVLSYEISSKIKQLISSFDLLNEIWKDRLTLYEENLDVQQWKRDANVLDSWLNEKENLLNEEWRKVDSVDDADNKIRNFDDFLITLDAQEEKFDALRRLTLLEKAYSQQRKKEAERIRVDDNRIDPKKETIKTFEKQNKLQDRRKERERRMTQEVSLLKPSPSFTEAQMQCASRTLPHPRRGTEPVPPARNTSFESKETINIGTLDSSTADLDKAHSHASLSIVRNDVTPLSLQRVRSARKTPSFTTRRSHPMKNVEWKDYGSIDMHGHLDRKQSLQSGGKRATIRTWKRYYTILCGQLLCFFKDEESFMTNSAASAPINILNADCSAYPEYMKKKNAFRLKIQDGSEYLFSCSDEKLMLEWVAKIKFHASLTPSQQLRSFDMGEAPPTHAPPPRPNDSLRRHTTEVGSSEQRTLHYSENEIEINGAADRDSGSIGSSGHAVSHSKVEDNDFVAWVESHDYSRISSATPPLPPAHNDDTESVKSKLIFLEFFKFFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4U3</accession>
    <name>A0A0N4U4U3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS6184</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4U3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4U3"/>
    <dbReference type="WBParaSite" id="DME_0000182401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000182401-mRNA-1"/>
        <property type="gene ID" value="DME_0000182401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="119"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN56211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000182401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="44341" checksum="10487EB46F26983A" modified="2015-12-09" version="1">MISQKGRFLFTSESVGEGHPDKMCDIISDAILDAHIARDPNAKVACETVTKTGMVLLCGEITSKAKVDYYQIVRDAVKDIGFDDSEKGFDFKTCNVLIALEQQAPEIAAGVHQNRSDEEIGAGDQGLMFGYATDETEEKMPLSLVLAHKLMAHHHALRKSGVLDWALPDSKSQVTIEYKFDGGACVPLRVHTIVISAQHKASVSLEKVRKDLTEHVIKAVVPSNLLDANTKYYLNPCGSFTLGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYGARWVAKSLVTAGICRRCLVQVSYAIGIADPLSITVIDYGTSPLTEDELLTIVNDNFDLRPGIIIRDLKLKSPIYMETARNGHFGNPKFSWEQPKQLKIRRAFAEKLSLAAKPKVPLIGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4W1</accession>
    <name>A0A0N4U4W1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6208</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4W1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4W1"/>
    <dbReference type="WBParaSite" id="DME_0000184801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000184801-mRNA-1"/>
        <property type="gene ID" value="DME_0000184801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000184801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="889" mass="97369" checksum="4B089DCE26F1F380" modified="2015-12-09" version="1">MNGSFLEHAQLPSVSKPSNSEQEDGEVSDESNSGMADDNKAGEQLRNSLRKKQISSSNKNNEDSNISKKNALERLKNLKFNLKPTISLESTSERSNRERKDRPGRALSPRREGDDERRLKKRRLEEKSDEERYGSKNTDRRPPRLAFSPPTLPRQIELSKVVDQPTTLRQRVERLINVSNSEIINMNDLELRSHLARMIHLDREQNRLLCGRKTQIDELKEMYKTIRKEVERLMNHLPRNLKSDIHLPLSDVDSKNMTSQITENFGKCVDEKQHTAGFNVSIAANPRINPAVETRFRFNVPPPIISGSVFPAGFIQRPPGAIQPLNNPPIGLAQTRPACPPVSGTQCGMSGPPPRFGMDTKPLFTQVENAPSFLTTGSFSTLPAQETINPSIQQLNDPNKISLTSNIGGIQTHTALGNVIDSLQPAVLYTLPSDHLKRIDEIIDDAQSVLLEKQNANTNITSGQARARDNFISKSIASSSLPISYPPPSLVNRATGTRPLIEPISSVPFINVPPPNFIKSTASSTAQPTGILMPIRSVLPLERPPSLSASDAQSYNAGNSHFKSGDNQSSKVINLAVSSLSSNSSLVNTLPVFSAPPPCSNSTSSAVPASNISINQQPNFSLLKMNTSEITSDNRLAAVAPNITSINLSVPPPLFNVPPPRSGQPILPCFSSPPPNTKPIHGQSNRGLSPSATTSILSSGHTVNLNTFSSGVPPSLNLNIGSTSMSHLPPNLSCPPPPFPRFIHPNISQNPQMSTTTGHSSVELAPERNTYNRSDSRSMLSNAAVLNMPARMERSSSRSPKRHAIISSDRNTASKNKGASTLTNKFRGHNRTALSQERYSSRSQQSSRKRQLNESIAVLPSENDPSKMRDKHDESNIYLIVSDDDDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U590</accession>
    <name>A0A0N4U590_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6362</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U590"/>
    <dbReference type="STRING" id="318479.A0A0N4U590"/>
    <dbReference type="WBParaSite" id="DME_0000200201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000200201-mRNA-1"/>
        <property type="gene ID" value="DME_0000200201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000200201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33196" checksum="026A206CF19B14A9" modified="2015-12-09" version="1">MSGAPIFHNIHLWLIRSATNGVTSNTRSTKGVSTSGDSGINDDKPSLEDGSKRKSSCSDRSNDDENEKADVNCCNSYGNSKALEQLEQLILSDEWITKEFIDNHQTAKNVSSLSYDTILQSGRKKISRFIHKICSQPRTIAQNLQRKTALCTRGEALAVSTWKVITPIDIPSQAITVHTLSKYRMNIARLSRVRLSHFRFRAINLGSKQRYCLYHCVVLEDVVVIMSEKARSALIRWKLLNDYMAYACFKGEFWNIISVYAVADDRSKDKFYAELQLLTTPLLKHDKVIGGTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5E0</accession>
    <name>A0A0N4U5E0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GpcrRhopsn4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6419</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5E0"/>
    <dbReference type="STRING" id="318479.A0A0N4U5E0"/>
    <dbReference type="WBParaSite" id="DME_0000205901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000205901-mRNA-1"/>
        <property type="gene ID" value="DME_0000205901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205745at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000205901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21852" checksum="C2AEF2DAB264B8A4" modified="2015-12-09" version="1">MFGKTESKRSYGVLYTNKDWHYLDRFCFISENGNLQYLLQYPKDYEVQSMYIYYDTNTQWSSVYDKNLTCSEKISILDPNNNQKIILTNKNENNECAIYTKNEEKCSQRAMWWFLALANCNSTKGLYIEYDLLMTNGDPNEFWFGHFSADEFYVLPVDLLFLLINLVILIVAIIIACKFFPAFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5H7</accession>
    <name>A0A0N4U5H7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6462</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5H7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5H7"/>
    <dbReference type="WBParaSite" id="DME_0000210201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000210201-mRNA-1"/>
        <property type="gene ID" value="DME_0000210201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850233at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000210201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30513" checksum="E14D4B81876B9F23" modified="2015-12-09" version="1">MNVIISFFFYCRKSLIEKRAFDKIEQSDFGLLRKRFELFYPFRQGKNMEEMNNSGKYHHLDEHYHTIKKRGFDRIDDADFGLFKKRAFDRIDEGFGLMKKRAFDRLDTSEFGLRKRGFLPYYLEQYEISSPFRNHLFDFLGKKGILLLIEPNYNENVEQRYKRAFDRIESSDFGFHKRSIADKMNDNKNIDEIIAHKVTKRPFDRIERSDFGPMTKRTPATLPESFMEFDPNLIDIAPNDNILLSGPAETIFLLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6F2</accession>
    <name>A0A0N4U6F2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6854</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6F2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6F2"/>
    <dbReference type="WBParaSite" id="DME_0000249401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249401-mRNA-1"/>
        <property type="gene ID" value="DME_0000249401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17895" checksum="9A55475349997843" modified="2015-12-09" version="1">MAVMVVPNRIDYSMTKGGLRMWVVLLVFFFLCSSLYTIFSAQELAELPLSIEDDENIDYDGEIEDNGDEMANHNRRFEKDTTPSKANVIYSKVSDEIRRFHQGINDDAGDFLCLVIREFFEGNGMVCCFNGMENLDSCVTMGRTLSLKVKALVVLVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6P6</accession>
    <name>A0A0N4U6P6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6972</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6P6"/>
    <dbReference type="WBParaSite" id="DME_0000261201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000261201-mRNA-1"/>
        <property type="gene ID" value="DME_0000261201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000261201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8812" checksum="FB6D8CB4CEDB1811" modified="2015-12-09" version="1">MFPLVKHDFIIINNIKGVAIGEMALWREAWHRAARKQLIWLHLARTQTGSAQAVTLRKRCELFEDEEKEARRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U793</accession>
    <name>A0A0N4U793_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS73</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U793"/>
    <dbReference type="WBParaSite" id="DME_0000284401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000284401-mRNA-1"/>
        <property type="gene ID" value="DME_0000284401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5776189at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000284401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18421" checksum="0FB0F9FC2BD0BADB" modified="2015-12-09" version="1">MNFNNEDFDPLNAHGGIFRSFKWTREELKQISLHHAVAEYDKLINLMKAKLQQSKEIPTSGRLKIEKFLAQNEPPPAVIRLLDPYDKSSVRGLFLSLLSIDAVVLPLIVANLFSENSGGAGGPPAIKALHEIGEIGRAMDFVLHRLRMLSPEEQSIVLKYFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7F3</accession>
    <name>A0A0N4U7F3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS142</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7F3"/>
    <dbReference type="STRING" id="318479.A0A0N4U7F3"/>
    <dbReference type="WBParaSite" id="DME_0000291301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000291301-mRNA-1"/>
        <property type="gene ID" value="DME_0000291301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000291301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51714" checksum="AF0BB26931110CC3" modified="2015-12-09" version="1">MLLKTGNLFIQLNRRSICGKAEMDAKIRAYQQSVSVLDDAIDKITFSQLPANNPIEDHYSIAKCLHTNSYFFGIFDGHGSECCSRHVSVRLYDYLCASVLKKYSFNNLSDRDQLKWIFSSSDRDFSPSFRQRHAANLEKFIKNDSMDTATMMKVIENAFLAMDDDISNDALPDTNGNISRNRVKIAVSGSCGIVAHLRKNHLHVANVGDSVAILGTLKNGHIAPQLLSKLHSCDNTDEIKRVRSAHPISESETILRSDRLLGELYPLRAFGDVRYKWPLKLQKIILAPFDIDVPNGLQTPPYLTALPEVFYHRLTSDDQFLILASDGLWEWLDPDTVVRLVYDHTIGTETLTPYQPDYHLSLSEASHFNSHILKLIVFERLQKRLLGECKKPLDENSATHLIRHALGGCASDAEEQYLRLKDMLESPPGTARNIRDDISIIIVHFSQQYLQMNRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7H5</accession>
    <name>A0A0N4U7H5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS167</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4U7H5"/>
    <dbReference type="WBParaSite" id="DME_0000293801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000293801-mRNA-1"/>
        <property type="gene ID" value="DME_0000293801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DH_dom"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_Tiam1/2"/>
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        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000293801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40554" checksum="BCB68F761EF157A3" modified="2015-12-09" version="1">MALEKKGKINGLHGSLSQSNELAEEQLRKTINELVATEENFVKDIRKLVDQYLKPTNLPILQTAGRLLRVQTSFLFALRDAAGDVVHKSDVPPEQLRDSLIRVSTLFINKCNKFKIYSDYSAAYLRFQQNKKPNRETEELLNKNNLSGEQSDSAQSLLIKPIQRVLKYPLFIQQIKDNCLNGSVEKQQAEQALRRMHALADYVNEMQRITEQYGPIIDEISMKHSAETHMNLSELLMFANVNWLNYTENRSRPVACVAFVFSSLIFIYCPSLSKHKNRLYRILPINEIEVNENITNSKESQILFVLIHIKKSQETIYHFCCFDSEIKNHFIKSIRKAAAASATANSTNNTIADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7M0</accession>
    <name>A0A0N4U7M0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7149</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="DME_0000299001-mRNA-1"/>
        <property type="gene ID" value="DME_0000299001"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000299001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="43694" checksum="D6905C2ADDF98855" modified="2015-12-09" version="1">MFDHDDLNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPEDHQDGSNSNRNKRETKNDEDQQFRFRVNPVNHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEDQQFRFRVNPVDHQDGSNSNRNKRETKNDEGQQFRFRVNPVDHQDGSNSNRNKRETKDLFQYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7S0</accession>
    <name>A0A0N4U7S0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Extended synaptotagmin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7206</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7S0"/>
    <dbReference type="STRING" id="318479.A0A0N4U7S0"/>
    <dbReference type="WBParaSite" id="DME_0000304701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000304701-mRNA-1"/>
        <property type="gene ID" value="DME_0000304701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08391">
        <property type="entry name" value="C2A_C2C_Synaptotagmin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04050">
        <property type="entry name" value="C2B_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000025">
        <property type="entry name" value="Extended synaptotagmin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037733">
        <property type="entry name" value="Ext_Synaptotagmin_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037749">
        <property type="entry name" value="Ext_Synaptotagmin_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="17">
        <location>
            <begin position="83"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="252"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="404"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="574"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000304701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="698" mass="80189" checksum="037FAE578379BF2A" modified="2016-06-08" version="2">MRIQTYIVPVCGSFAILSGCYLLGHYDCSFFWIILLVILNGIKSFMWRKRQKRLIALRQATLKEREVIMAQLQDLPAWVQFPDTERVEWMNKVILQLWPYIGEYSKQFLREFIEPQVKAQMPSAFKSFKFTKMDVGDIPCRVGGIKVYTHNVGRDRIIVDMDVAYAGDSDFSVSVAGFTGGLNQLQFSGKLRATLKPLLPYPPMIGGISASFLEQPTIDFNLTGLGELVELPGLMNAIRSVVNAQVANICVLPNEIVVSLAPNVDVTKLYFPEPDGIIRLKIIEAKNLENRDISFLKKGKSDPYCEIQVGSQFFKTRTINNDLNPVWNEYFEAIVDQADGQKLRLELFDEDTAGADEELGRLVIDINKIRDGIFMDKWCPLEGCKHGDIHIKADWFDLSSSVKDLEKQDWNMDWLHADKPMHPAILMVFIDNISDLPYPRAKLEPSPFIEISLGKDLYRTPVKVKTVNPLFQSKFTFFVRHPEGQELKIEAIDDNTKRSLGDLKIPLNSIVDEPKMEIFQQTFVLNQGVHQSPIVITARIRVHIQKSRLSYLFDENWKKFFWLNFSFLYFRDYSRGRLQFSLRHDKTTNKLIIIIHSATKQGSADPYVSIKLVSIDNSLPIQKRKTAVVQQSLEPQFDNHFDFDVHSSDLRNYKLQILVKDATNYGVFAKAPIIGMIIYANSSNRWIFPQFFQLGHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8K5</accession>
    <name>A0A0N4U8K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DAO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS249</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8K5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8K5"/>
    <dbReference type="WBParaSite" id="DME_0000338301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000338301-mRNA-1"/>
        <property type="gene ID" value="DME_0000338301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF28">
        <property type="entry name" value="D-ASPARTATE OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000338301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42923" checksum="6FFEDBE930139A11" modified="2015-12-09" version="1">MKRKLSFSVAYQQNIAVIGEGAIGVATALSLIKRNNHINLTVFYDRPFEKTVSCCPAGLFRIDSLKHRPFGKISFKNYAKIFREVPPSISGVNLISGHILSTNLTELVEQLIQNLFENDNIESQTCNKNGLFLKERIYGDIVYNFRYLREDEMKQFTEQKDDGHMFAIHFTTFTTEGGKFIPWMKKQLLKKGVNFIKRPITTLSELYPDFDVIINCAGLNGGILAADGDDKNMFPIRGVVFKVNATWHKHFLYKRFLTFTIPTTDSVYIGTVKQEGRYDLEITPDDRDDILGRYYELQPTIKDAEILDEWAGLRPGRIGGVRLEMTTIRYPTLKNYGLMEKIVKIVHNYGHGGHGLTLANGCGETVADLIFGNSTKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9R8</accession>
    <name>A0A0N4U9R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7853</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9R8"/>
    <dbReference type="STRING" id="318479.A0A0N4U9R8"/>
    <dbReference type="WBParaSite" id="DME_0000384801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384801-mRNA-1"/>
        <property type="gene ID" value="DME_0000384801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF55">
        <property type="entry name" value="OBSCURIN ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39106" checksum="49B7D6C44D29E2F8" modified="2015-12-09" version="1">MEAENMIFKIPRLILHADQYYLIKNQEIDLSCQIEPGWRGATIASVQWIKDNTPIENCIDRVRNELIADGPTLRILNNQYQPEGDYQCSSLIRGIRISNGLHIDTQLVSAPVKFRKARISKFEKVNIETIRVYQPQAIRIPCLGMPDVVPNPPGIHFEKDENVKKLGLSGDRRFLLTSSGMQIAFSMVSDSGDYYCVVTNLFTNKTRKSPYPVRLEVVSARINLTFPVLIYPKIKSSVFEPIILHVVKGKTVILECMMLNVRIMWTKVKPSTSGLVFNNDRLRFQQISGNLVINLLNEADDGVYVCEGYPVNTNNLSEIPKVFYQLIVHAPIDVQLMAIRQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAP2</accession>
    <name>A0A0N4UAP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcription factor Sp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8116</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAP2"/>
    <dbReference type="STRING" id="318479.A0A0N4UAP2"/>
    <dbReference type="WBParaSite" id="DME_0000423301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000423301-mRNA-1"/>
        <property type="gene ID" value="DME_0000423301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF165">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000423301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34040" checksum="D84CE375C77C9A69" modified="2015-12-09" version="1">MHLKFISNDQLKIAFIPVQMQTAPDSKPMLANLQPAPTMQQLHTVEMQPIAPQQQQSQQQQPPQQQQPKQEMGSCSLTAAHQRITVGSLHFQQDPNDPQKWIITNESGEAPITGLSQGSVVNRQPEYDVTPSASTINTSMQLSFKQKTPKRTACSCPNCVNNSNNKVRTGEKQRLHVCHICDKTYGKTSHLRAHLRGHAGQKPFACDWPHCQKRFTRSDELQRHRRTHTGEKRFSCGQCGKKFMRSDHLTKHERTHSTVRGHNAHNSHNAHNAQQQQQQHVGESGQRISDLSKNYRPPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB07</accession>
    <name>A0A0N4UB07_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8249</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB07"/>
    <dbReference type="STRING" id="318479.A0A0N4UB07"/>
    <dbReference type="WBParaSite" id="DME_0000436601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000436601-mRNA-1"/>
        <property type="gene ID" value="DME_0000436601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000436601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="560" mass="65767" checksum="0CB2724797EAD54A" modified="2016-06-08" version="2">MSKQIKWYRMENMLHCRVLRLRKHAYRRPKCSYKESDSDTAESDCSVIFQKNAQWNGDLALFILKQCLLSKILLFITQLFFNWILNDFPTDAFKGIVIKEKLSFVDHLIRFVFSGLTRWDSLHFLHIAQYGYSFENILAFFPLFPFLIYYFTLLWNWIIPFIHFSTALIISAIFINFVLFLICGQLLYAVSLTITKSSKTALLACLVFTINPASVFFASAYSEPLFMALTLSGLLVLYAHPNMPFIRHIGASIFFAFAFLTRSNGIFNFIYILHQLFVETVYSSEKHKYIWQLKYTIILYKVIIIIFVHFLIVRFIIVGSFCWVILGSLLISHDVQMKKLFCESNFVNKSAIPVEILDFAEQKNFVLPGEISKISWCRLEFFYEYYPFWIPLPSFYAAVQQKYWNVKSFGYWKLKKIPCFLMALPAVLIVFYGCYRELRRLARYSSSVVYAILYICRDSISLLPFCCHSFILAILSLILYNAEVATRILFSSSPYIYLVLSQYMHQRTPLVTLEDVQYPTLLPFFTNFCRTHIIHALLLGYLLCYFFIGTLLHVNWLPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBH6</accession>
    <name>A0A0N4UBH6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch-like protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8437</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBH6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBH6"/>
    <dbReference type="WBParaSite" id="DME_0000455401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000455401-mRNA-1"/>
        <property type="gene ID" value="DME_0000455401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775046at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000455401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38752" checksum="439D19E98FA964B9" modified="2015-12-09" version="1">MQMIGPTIFEKSDIRREMIRMKSSLNCIRILDWQKYASRRIPRDFLMAIGGWEKNGPSKAIEIYDIHNDEWRRVAHLEDERCIAYHQCFFVKKRIYVIGGFDGSQYFNITRCFDPLLQKWKELAPMNSGRCYVAACEIDGIIYVAGGSDGRNRLRSAEKYNIEQNQWTPIRNMIQRRSDAGACALNGKMYVAGGYTGELVLQTVEIYNPENDTWVQIATMDSPRSGLACVAIDNYIIIAGGFDGVNRLRTVEKLKDEIIYAVGGYEHTMVRTVLTFDGRKWETKGRLTIPRSALRVILLEHWTNPRSILPSEEQNLESQETLASSPEQVNEFQNFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBI4</accession>
    <name>A0A0N4UBI4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8447</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBI4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBI4"/>
    <dbReference type="WBParaSite" id="DME_0000456401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000456401-mRNA-1"/>
        <property type="gene ID" value="DME_0000456401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042652at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF1">
        <property type="entry name" value="DOXA1 FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000456401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27230" checksum="9E5A3B457D48A948" modified="2015-12-09" version="1">MDAILGVRMGLEHMNVTLKSKSSTSPANDMHKRSLLNDLEYNERFEFLNVYSMEKELMKSLQKGLPYPIIKVIEYLSVDRAGFTWGRQYRLAGYYTLCLLWTSFIVWIIKMVILCLVPHHFCKLVLSVGVLILSSDIVYIIFVPKHLHIPFPSPDGSLAILDFRLSFCFYMTFLAGFLSIIVGVVLCYLQSASIYTLQTFLSCNIDEYSCSFRRDSSPEVKKMDSIEYSNTLMERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ6</accession>
    <name>A0A0N4UBQ6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8536</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBQ6"/>
    <dbReference type="WBParaSite" id="DME_0000465301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465301-mRNA-1"/>
        <property type="gene ID" value="DME_0000465301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="120"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="313"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70865" checksum="608F86F92233E10D" modified="2016-06-08" version="2">KQFSIKIKEFRLERYVSTTLKLCISNQPSEPSNLTGKDLELYKLYRPERETPSKRGVALLKTPRLNKGMAFGLYERQYLGIHGLLPPAFMTVEQQVFRIITQLRSQPNDLARYIQLDNLQDRNEKLFYRVLCEYIKELMPIVYTPTVGLACQNFGYIYRNPKGLYITINDNSISKIHHILSNWPERHIRAIVVTDGERILGLGDLGAYGIGIPVGKLALYVALGGIQPQWCLPVLLDVGTDNEELLNDPFYIGLRRRRVRGEEYDLLLENFMKACTKRFGQKTLIQFEDFANQNAYRLLDRFKQRYTIFNDDIQGTAAVVLAGLLACCKVMHKKLHENSFIFLGAGGAANGIAELCVHHMCDEGIPREKTYERIYFMDIDGLITKKRKSLSQHQVPFAKDMEECNDLLKLIKIVRPHGIIGASTARGAFTKEIIRFMAEINDRPIIFALSNPTSKAECTAEEAFCHTDGRVLFASGSPFKNVHFKGRLFKPGQGNNAYIFPGLALAVVLFQIRHIDHKIFLIAAKTVARCVTEKDIEVGRLYPSLKSIREVSIQIAIDIAEYFFQKGIADLYPRPEDLEKYIRTHIYSTSYDELINTTYQWPENDMKHGFPVPVSMQDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBR3</accession>
    <name>A0A0N4UBR3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8547</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBR3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBR3"/>
    <dbReference type="WBParaSite" id="DME_0000466401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000466401-mRNA-1"/>
        <property type="gene ID" value="DME_0000466401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5816567at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000768">
        <property type="term" value="P:syncytium formation by plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.60">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3980">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029213">
        <property type="entry name" value="Fusogen_EFF/AFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043076">
        <property type="entry name" value="Fusogen_EFF/AFF_dom3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415">
        <property type="entry name" value="EFF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415:SF2">
        <property type="entry name" value="EFF-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14884">
        <property type="entry name" value="EFF-AFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000466401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="62068" checksum="4583FE657E39B49A" modified="2015-12-09" version="1">MRTYSRSFHYSWLLYVFIKNFRSVMYPWLHTLTLVQLEHHHPVSQQYTFAIPEVHTKCVCDCNPASDICSARTHSFTICNSTSNSVCYRTFHPSQSDSGCTQGSQSKLCCEVNFTPYRNLSYMAVKLEQPSTFAIFKYSAYDYSAGRWIQKDKSTLRIEIDGRTQSLFLDRHKIIKLGVSAWGRTSHQLESGMYFAQSNPGGEMDELRKQQINEINENNFERLGWFRKDATGRFSIRNGKVKIQKIHFAKVENCKDQKSLSYLDAHHYVDADNHEDYERFRFEEPVDQIYTWIKSARLIDGSARQALIVHSGGTNLEISLQVHADESSVSLVHNFSKMSDFSGSIITDFKSNRYFNLTVYNSTGILHGIVKKSVAKDDLDDFFFTTYVDDLRSTNKTIIIPFPAMVGGNDRLVCMRADDEPSETEICRIVIYKEQPLEINLLENTWRELGGYCPECNKLTVNGFLSNLNPMNWVSSINSLSNFIMMISDIIIYLMLLLFVYFLLTKCILPICKCGLCPASFFSSHCKKINNIEKNSRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC05</accession>
    <name>A0A0N4UC05_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8652</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC05"/>
    <dbReference type="WBParaSite" id="DME_0000476901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000476901-mRNA-1"/>
        <property type="gene ID" value="DME_0000476901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876405at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000476901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20987" checksum="0660D85AB4FE8FFB" modified="2015-12-09" version="1">MFDEEEPGKPKNWGCTIAIIASMTIVNIAIFIICRILLDSEDEFDEPLLQGKLRDDITFFLGMFSMTFCFGCCCCFCCGGAVFREHMRLVSKEHKKFDGSTDEKIIKMRIERNNRENENKYIAEDGGLRRKFGEKCINNGYAYSNIAFNECSSEEKGEIFRSLALAASAPKVQSSKFRSMSIAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCJ7</accession>
    <name>A0A0N4UCJ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8793</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCJ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UCJ7"/>
    <dbReference type="WBParaSite" id="DME_0000499401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000499401-mRNA-1"/>
        <property type="gene ID" value="DME_0000499401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12344">
        <property type="entry name" value="RRM1_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF1">
        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000499401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34582" checksum="38D1F870D9673DA5" modified="2015-12-09" version="1">MNRTNGESDRTLWMGDLDEKWDANTIVEAFARMGEQVINVKLVSDKQSGKQAGYCFVEFPDRESARRAMLRINGKIMPKSKPPAAFNLSFANSPSAAYTEYNLFVNNLPSNVDDASLFLIFGERYESCRGAKVYRNTDGSSKGLGFVRFSNQTDQQRALLEMNKYRVEGRPIFLKLAQPKYRAPRQPKFQGVSGADTFGYYVQQQNIPDTSSYYNTGNASTTQHSNYPVSDAYSTPVANQSAYYSGVGSVDSYIPRGTLPIRDPTAEESNDFLVKNGEEFYEALERSRWSQVVCDANITIDDLIHSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCK7</accession>
    <name>A0A0N4UCK7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8803</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCK7"/>
    <dbReference type="STRING" id="318479.A0A0N4UCK7"/>
    <dbReference type="WBParaSite" id="DME_0000500401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000500401-mRNA-1"/>
        <property type="gene ID" value="DME_0000500401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064469at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="7">
        <location>
            <begin position="247"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000500401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55004" checksum="AB2CA12B86D27C1E" modified="2015-12-09" version="1">MEPEFVSSQCGTRKLVINGFTYVCQRKGERRTHWRCDRYQKDKCRATALTENGKVHIKHATHNHPANTSIFVSKRLYSKLKMAMLQSSESVPEIIRRVLSMNNEEAAIAKLPTFETLCNSMRKFRAKVQQARANQATDPSVFSVFSVDPRLSSTNNDLYNASSAEESFGINIDGLNLSNIAEFNSGSAGTRFDEPIMEDVVATSSTSQAGDKADNSEMMEYKVFENAKTQLENWERKQLCNVRKIAESSISRRSIMAMFSNNDEPNNSSNEYYNSCTYAELVQYRQLEIPFLIEFLTKAFTELSHLEKDIKVSIFKNFAPYFWLIEIGYSSINFETGSRRLIVSMLRYVDSVCLPDFLEKKKSSEKLMSSFCELFDGIHEHIVVPMQSMKILEGEFALLVALLLSESGAKLDSNDDLVAIRDNVLREIESYYRFNNIECYAFRIAALVRMTFFVMELRKQFSSQMEEISVDNVFEVAPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCL7</accession>
    <name>A0A0N4UCL7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS8816</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCL7"/>
    <dbReference type="STRING" id="318479.A0A0N4UCL7"/>
    <dbReference type="WBParaSite" id="DME_0000501701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000501701-mRNA-1"/>
        <property type="gene ID" value="DME_0000501701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000058">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="REM-1" evidence="16">
        <location>
            <begin position="166"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="16">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="770"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="799"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN58843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000501701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121017" checksum="9AE59391A0C00FED" modified="2016-06-08" version="2">MADVAQLGAHTWQSVDSDEILFFSSSFSTNQTVPEELLPLADRYSFKFADQRSLQRDIIELKRVIRCKLNKQMRIKQGYVQMQKVTKERKQLEFLKKEVRDLSDQISDMQDDLQTLDMYDTGAFDKSLTDEGKSNSVSTSPSDELVSSTHTLKDASLPRVGSADEILDQSAGVSNAVKSRLPALQKELGKELKVKEGLERFLNIGQTNRKLQENSKNMLDDSKAKIALLRMQIEKIQHQERLDSGLLGKGVQSRNEIVIDGLINKLRKEAAIAEGARNMIKILKSQRKSDGKSLAQAFDNKMQSEEKLDLIRLALNKYSSQLPLDSTKRVEIFEALFEIDNGGFSMHTRDDNQASPSSISASSFAQDCELKTGSLPRTSNFSRLHSTFTQSLAVSGRLEVRIMGCQNLMVDVARRAPRPEISSILAMGGETSSMVGFLPQKNRNARGLGPRTSRTRSSSVWCSPTNLHGALILTSFSSSALRMSQTDEVIATLRLDSKEVGTTDARPAAHQSWDQRFSIELDRSRELEIEIRYKDWRSMCAFVVIKLGDIVEPAERTGVVLQLEPEGELFAEFKYLNPVVSRKPKLERQKRLFRVKERKEIAGAKKELGIAAWSRLIKQFGGSQTNESGEPVTSPIMFGFAGAPTHGFGLTHTSKNSTAISTRMSTERPLPVAPIYDVPPVDLAQMSNRSTSSILTGGKNKIRSKLQVAHSSEESTVLPEPLKQFGTLVPKGSSTTDISPNFVTSLGSKSHGIPPPKAPRAVTDITIDKFRLISVLGRGHFGKVILAQYKPNNEYYALKVLKKGDVLGRDEVESLMVEKRIFEIATRHRHPFLINLFACIQSKEHVFFVMEYTMGGDLMRHIHDDIFTEERSCFYAACVLLGLEFLHSNDIIYRDLKLDNLLLDRDGYVKLADFGLCKEGMGPTDRTSTFCGTPEFLAPEVLTENSYTRTIDWWGLGVLIFEMLVGEPPFSGEDEEEIFESIVHDDVRYPRFLSIESITIMRRLLRKNPDKRLGSGENDALDVKQQRFFKKNMEDVSNFDEEFTKETPRFSSAKGKRLITDDDQLLFKDFNFIAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCR9</accession>
    <name>A0A0N4UCR9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCR9"/>
    <dbReference type="WBParaSite" id="DME_0000507601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000507601-mRNA-1"/>
        <property type="gene ID" value="DME_0000507601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041080920" evidence="1">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000507601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26525" checksum="16211C3DCBF5D2FA" modified="2015-12-09" version="1">MFMENIKAILIYISVIKAQLWPPPPYPIMVANPYINTMRHHNPYGGFSSNCITISRVPCRNSPAYNFIEMGQFPYNQQLPFVNREIDGNFNNLVATFMPNNMASLINPGLTWVNSALPFINAGTSSLLNSRQSIIDPKSIINRGSTINQGTTLTGDALQNIIDIYSRNSLLGQTGSNLLSGINKEKFQVQGCSFDTIQNSCTNGLNLCRGRCKDFGTDLLHDCRCIPDDLSSMLGHIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCS2</accession>
    <name>A0A0N4UCS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8879</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCS2"/>
    <dbReference type="WBParaSite" id="DME_0000508001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000508001-mRNA-1"/>
        <property type="gene ID" value="DME_0000508001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000508001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14621" checksum="36F202C2F94DC4DC" modified="2015-12-09" version="1">MLYSQSHVPTLHEIRGYSDVELKEIFRLAEISNQRPPEPRFNDEIVNGRRESIPNERNNARLILQNYRETMQQSAYDVGVKFGQLAYTSAKAILSGAEEFNRILKAGAAKISSDLFLANYKPFNKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD85</accession>
    <name>A0A0N4UD85_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9073</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD85"/>
    <dbReference type="STRING" id="318479.A0A0N4UD85"/>
    <dbReference type="WBParaSite" id="DME_0000527401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000527401-mRNA-1"/>
        <property type="gene ID" value="DME_0000527401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040022">
        <property type="term" value="P:feminization of hermaphroditic germ-line"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000527401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53916" checksum="EA101638A020E85D" modified="2016-06-08" version="2">MSSGRRFPVDIYYTKAPEADYLDAAMVTVLQIHLTQPLPGDVLVFLTGQEEIETLMESLLERTKYLGKKIKELIVLPIYSNLPSDLQAKIFEPTPPNARKVVLATNIAETSVTIDGICYVIDPGFTKQNSFDARGGVEHLQVVTISKAAANQRAGRAGRTGPGKCFRLYTSWAYKNELDDQPIPEIQRTNLANVVLMLKSLGIHDLVHFDFLDPPPQETLVIALEQLYALGALNHRGELTKLGRRMAEFPCDPCMSKMIIASEKYECSEEIITIAAMLSCNAAVFYRPKAMVIHADAARKGFWKPGGDHLTLLYVYNRWKETNYSSQWCMENFVQHRTMRKARDIRDQLEGLLERVEIEQKSSDDSVAIRKAITSGYFYNCSKLDSSGHYKTVKHKHTVHIHPNSSLLEETPRWMIYYELVSTSKEFMREVIEIESAWLMEVAPHYYKLKELEDPTNKKMPKQKGKVAAELFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDF6</accession>
    <name>A0A0N4UDF6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS9164</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDF6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDF6"/>
    <dbReference type="WBParaSite" id="DME_0000536501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000536501-mRNA-1"/>
        <property type="gene ID" value="DME_0000536501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN59191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000536501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12378" checksum="EE8879C210FA9F99" modified="2015-12-09" version="1">MLPFCPICGALLNVDEGEHCFRFSCRICPYVQPIIRLVKGRHIPSSKAIDVIIGGPRAWDNAQITNETCPRCRNSRAYYLQIQTRSADEPMTIFYRCASSDCAHRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEC8</accession>
    <name>A0A0N4UEC8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEC8"/>
    <dbReference type="WBParaSite" id="DME_0000572701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000572701-mRNA-1"/>
        <property type="gene ID" value="DME_0000572701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000572701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15703" checksum="2BD87D1BD2B70D4D" modified="2015-12-09" version="1">MGITLPSKGKSGWCGDILIISKRCLSNGSHPLEARNNEIRRRSIRACGTYMVVHASSLDAERAIRRNFVTYIGPLINLKNSLGMLLFIKKNDGTTLTIDMLPHDSIGELLKEIEAEFDWSQDRLALNKAKLFYRGSSTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEJ1</accession>
    <name>A0A0N4UEJ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS792</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UEJ1"/>
    <dbReference type="WBParaSite" id="DME_0000579801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000579801-mRNA-1"/>
        <property type="gene ID" value="DME_0000579801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6589456at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF21">
        <property type="entry name" value="PROTEIN 4.1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000579801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46743" checksum="9340A288998DEC5A" modified="2015-12-09" version="1">MGSEVKSNDELKEICKENVKKNNVQEAKVTFLDATQHSFFIKKRATGGELFNEVVSYIHLNEKEYFSLSFGDNTGTQLWLCNDKRISKQLKGEPWIFNFRVKFYPVDPTTLNDDLTRYQMCLQIRSDIYSGKISATFATYALLGSYIVQSEFGDYSVSPEYDSFLRNIHLAPVLSDALLDKVQSLHKQHKGQSPADADLQYLENAKKLSLYGISTTLAKDSKGNAVAFGIGAHGIHIYQDRIRIYRFIWQNIIKIAYKRNIFTIKLRRGELEKNETNISFKFADYETAKRAWKFAVENHTFFRLIRPDEKPRKGFLHWGSGKFSYQGRTQFQSKMASQMFGNSAPNIQRSQSARFSCKSDGNGAFFNLLPMLEIYIESENFLLIKSISHNTSHFIEFNLQRLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEQ0</accession>
    <name>A0A0N4UEQ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9393</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEQ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UEQ0"/>
    <dbReference type="WBParaSite" id="DME_0000586901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000586901-mRNA-1"/>
        <property type="gene ID" value="DME_0000586901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2377365at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21990">
        <property type="entry name" value="HMG-box_CIC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000010">
        <property type="entry name" value="Capicua transcriptional repressor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058607">
        <property type="entry name" value="HMG-box_Cic-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229940" evidence="8">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000586901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22616" checksum="2E5DF3DBD19A1529" modified="2016-06-08" version="2">MLSSLFKFIIFRAFLSFFVLDSLTECEDEDDNFENLMDDITSKKQKLQSENSLQMHIRRPMNAFMIFSKRHRPIVHEKYPNRDNRTVSKILGEWWYALGVEEKKKYHDLATQVKEAHFRAHPDWKWCSRERRKSVNGTRKEIDPISDEDAHNNLDVDNSDQMASDCIEGKVLPLFSPALITVYINFFHKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF92</accession>
    <name>A0A0N4UF92_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1030</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF92"/>
    <dbReference type="WBParaSite" id="DME_0000609101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000609101-mRNA-1"/>
        <property type="gene ID" value="DME_0000609101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000609101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30757" checksum="7841F9A9B140BAA3" modified="2015-12-09" version="1">MKQSSTKSQSKQASKSPKKKETKQKFSIELRSKGSPSRSKMESSESRKSASKSPSRSSRTPVRHVQKKSRSRSHSRGRKIDSQRMKPKVQAKSRPSSRSQKIIKSNKNLSKSFFFDRPKISIPSFGTDSRYGKIYVSTEKIIPSDDLHLRKDNMSPSGSLSSRQHVLDSAEELLRRRTFEPLHETMRSAPAFGSRTPSASPKKVERILEKAPSRMKAHFRRFGLFYIIVFLLCAVVYSVYSSGHQLEKTLKELQNRMNDFLIRDPKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFE0</accession>
    <name>A0A0N4UFE0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9441</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFE0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFE0"/>
    <dbReference type="WBParaSite" id="DME_0000614501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000614501-mRNA-1"/>
        <property type="gene ID" value="DME_0000614501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="12">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000614501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21726" checksum="1A82067A310450EB" modified="2015-12-09" version="1">MSQAFIGKPAPNFTTEAVINGDFKTISLSDFKGKYVVLFFYPLDFTFVCPTEIIAFSDRYEEFRKLDVVVLACSTDSKFSHLAWINQPRKLGGLGEMNIPILADTNHSISRAYGVLKEDEGIAYRGLFIIAPDGILRQITINDLPVGRSVSETLRLVQAFKYVDTHGEVCPAGWNPGNDTIVPKIVESKAYFAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFL9</accession>
    <name>A0A0N4UFL9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1139</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFL9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFL9"/>
    <dbReference type="WBParaSite" id="DME_0000624201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000624201-mRNA-1"/>
        <property type="gene ID" value="DME_0000624201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF23">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229915" evidence="10">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000624201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30147" checksum="22F828359C662F72" modified="2015-12-09" version="1">MLCSLLCITALPITPVLAFVKRWLFGSLMCKLVPLCQGISVLISSYSLCFIAVDRYRTIVTTTQEPWSINQALLLVVTSWITSGAASFPLFITQTLQPLVLENTTLCGYFCGEYNWPVNTHIKLFYGTMLLGCQYIVPASIMAFCYWKIIQKVRTDWIVAEGSLLTKSQQIQTAIRKKRVMYTLILMVVVFMASWFPLTIANIFRDFGIGTFLDAQMYFKLLNVHAVAMTSIVWNPLLYFWMNKVYLFDNFKSAFKRPLLAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFX7</accession>
    <name>A0A0N4UFX7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS9480</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFX7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFX7"/>
    <dbReference type="WBParaSite" id="DME_0000636901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000636901-mRNA-1"/>
        <property type="gene ID" value="DME_0000636901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="33"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000636901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35009" checksum="DBB24B738881F16C" modified="2015-12-09" version="1">MLYESCCHILWRRWLIHCYRSFTSRQLVYEEYGDPSKVLKLRNIDISDELKPKEVKISWKGSPINPADINQIQGVYPVKPDLPAVAGNEGFIGTEVTYLSPGDHVVALRSGLGSWQTHSVHHEDDLFKIDKNLPFEAAATIKVNPPTAYRMLKDFVDLRPDETIIQNGANSAVGKAVIQLAKAVNVHTINIVRNRQNLDELVDELKSLGADEVYTEKLIFCFLFYAQKVRLALNCIGGRSTSLLSQALSKGGVMVTYGGMSKQALMVSQFIDISLRGFWMTRWYIQQENKEVYIYYIMYLNHVSLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGL0</accession>
    <name>A0A0N4UGL0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAP1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1279</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGL0"/>
    <dbReference type="WBParaSite" id="DME_0000663501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000663501-mRNA-1"/>
        <property type="gene ID" value="DME_0000663501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000663501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16997" checksum="E9E24EDD599AF07F" modified="2015-12-09" version="1">MRSTSRPNGLIRRNARVHFNLGRLQVTEHELLKNRESSSQEHLKISEDRLTFTRMKHEQRLLKQLLMQLANPGDQIEALESRMSQRSTLIEGEIHQLSNLNNTIRNLSILFDFEEAFNSVEYSCSDESMPISNTQSEKEFDEKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH25</accession>
    <name>A0A0N4UH25_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1435</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH25"/>
    <dbReference type="STRING" id="318479.A0A0N4UH25"/>
    <dbReference type="WBParaSite" id="DME_0000682101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000682101-mRNA-1"/>
        <property type="gene ID" value="DME_0000682101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033563">
        <property type="term" value="P:dorsal/ventral axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000682101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21386" checksum="03AA63A28E5B2C28" modified="2015-12-09" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPSSFENVRAKWHPEVSHHCPNAPIILVGTKLDLREDSETVEKLRDRRLAPISYLQGVAMSKEINAVKYLECSALSQKGLKQVFDEAIRAVLCPPPKPKRSRKCTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH76</accession>
    <name>A0A0N4UH76_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1497</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH76"/>
    <dbReference type="WBParaSite" id="DME_0000688301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000688301-mRNA-1"/>
        <property type="gene ID" value="DME_0000688301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000688301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12050" checksum="A3430DF97DF3F9B5" modified="2015-12-09" version="1">MIGYTVTRNSIKTQLDHNQVGSIPRRKFGRPNLHDKVLNVETLASNKIEEKDEIKVETNAVGNAFFHQFNSIESPGNHQNESTHLFACNMYLLVILSYSCETGQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHZ9</accession>
    <name>A0A0N4UHZ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1679</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHZ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHZ9"/>
    <dbReference type="WBParaSite" id="DME_0000720801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000720801-mRNA-1"/>
        <property type="gene ID" value="DME_0000720801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000720801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34616" checksum="2B91A3136FD504F7" modified="2015-12-09" version="1">MSVPLAVEGMDALALAQEGERLCRENNMKSGIKYLELALEKKVDLGGRSLEAVSAIYSQLGNAYFSLRNFEKALEYHQYDLETAKILAEKSGLAKAHGNLANTYKALGSYDNAYDHAVDHLRLARELNDKEYEARALYNIASIYHCRAKSFIRVATRADDSTLLTMANPDITSQLQAAINCYFYYMLGDYKTAVHYHNKRLDTARQFGDRAAMRRAYTNLANAHIFLSEPSKALDYYRLAYSLAIELKDDITEAQCSFNVGNGAAISGDHLTASEFHTRYLKLARKLGDRVGEARAFATLASDYRNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI46</accession>
    <name>A0A0N4UI46_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pepsin-I3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9930</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI46"/>
    <dbReference type="WBParaSite" id="DME_0000726201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000726201-mRNA-1"/>
        <property type="gene ID" value="DME_0000726201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5828355at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.50">
        <property type="entry name" value="Pepsin inhibitor-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010480">
        <property type="entry name" value="Pepsin-I3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038412">
        <property type="entry name" value="Pepsin-I3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051901">
        <property type="entry name" value="Protease_Inhibitor_I33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37969">
        <property type="entry name" value="PROTEIN CBG07421-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37969:SF3">
        <property type="entry name" value="PROTEIN CBG13131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06394">
        <property type="entry name" value="Pepsin-I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55149">
        <property type="entry name" value="Pepsin inhibitor-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pepsin inhibitor-3-like repeated" evidence="6">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000726201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18508" checksum="9EA89958ABF3C97A" modified="2015-12-09" version="1">MIMITITTTSGNDLAMTTKQLIQQAHKEKISKASLVASHKNLLDGPARPSFCSLNDTLPVFLDGCMIQNNKIYVGRDYVRDLTPEETQELKDYIMKKREFQKYLAATINQLVQPLFSRTAFDFFNLFSDSRIHKTTTETTTTTETAIKQVEEPVAPDFCTAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIE1</accession>
    <name>A0A0N4UIE1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1730</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIE1"/>
    <dbReference type="STRING" id="318479.A0A0N4UIE1"/>
    <dbReference type="WBParaSite" id="DME_0000736801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000736801-mRNA-1"/>
        <property type="gene ID" value="DME_0000736801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000736801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35645" checksum="50D4339BBC7026E7" modified="2016-06-08" version="2">MIVSGFQHQVGGHFGLFVCGGHVCKPFNDREYDFYRQIDDRFAPYTTQCCGCISIIVQKYTKNALVLNADKEITCHTHSLSRDKITFYIAENDHVDSDFCDNNWAKQCQCNAVQMMIKHGHEKFLLLVNIVDEYICPSIIDLKMGTRQYGDDASDEKRAMQTIKCRESTSAETGIRLVGMQLYNPELNNYLYMNKYEGRAMDRGGLSDALASFFKSAGRIRCMILLNKLTALTKVVENAEGFRFFSSSLLVAFDGKTKTTNIDLSDSIDIRMIDFAHSTFNGFLNDKRYSGPDKGYLLGLNSLTRIVTDILMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIE3</accession>
    <name>A0A0N4UIE3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SUEL-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1733</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIE3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIE3"/>
    <dbReference type="WBParaSite" id="DME_0000737101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000737101-mRNA-1"/>
        <property type="gene ID" value="DME_0000737101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970528at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000737101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8748" checksum="21E16AF0FF4FE608" modified="2015-12-09" version="1">MVQPSTFEHDPCPTNYKYLQISYKCKPTSFDEQIFCEGSNMQLSCKQNKRLAIYSAIYGRTNSQATNCQSNTPLING</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIL3</accession>
    <name>A0A0N4UIL3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10017</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIL3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIL3"/>
    <dbReference type="WBParaSite" id="DME_0000744801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000744801-mRNA-1"/>
        <property type="gene ID" value="DME_0000744801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000744801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52502" checksum="21E9DB9E98B19158" modified="2015-12-09" version="1">MLNVISCLVHYSLHGTMRPRDSPALMQIPLMQFLHSCTWISFPPSSSATEGCPRTFLSLWLNSSRRNFRNYFEYLKRIREEFQRSKKIGNPKWAMKLPRHSKKESTGDVSDEEDIDNAVADLTQSAGKYIDKSKLLPKGVISVTCLNNITQGHRFGKLAIRAVQFHPERPVLMIAGENGIISLFEVGLPKSKESFLQDICFKNFPVTKAAFSSDGLKIIAGSRKQEYMFSYNLLDGKVLQLRLPKGVTKMNAGNFALSDDGRYMSVVTRNEIHIITVSSMEYIAYSVAPRYVISTQFLSSSSNIVYAMTENGEVLFWDIRKAGRLKSFMDEGVIRSTTMRISRNNQYIACGSNSGIVNIYDMSQIHCNQAPRPVRTFNQLTTSIKHLTFNNDSQILAFSSNIKENAIRLAHVRSLKVFSNFPSFNNHIGKPTTVDFSPNSGYMAIGDEKNFVNLFKLNYFERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIM8</accession>
    <name>A0A0N4UIM8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1756</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIM8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIM8"/>
    <dbReference type="WBParaSite" id="DME_0000746301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000746301-mRNA-1"/>
        <property type="gene ID" value="DME_0000746301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="74"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000746301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37621" checksum="10724688CE59B145" modified="2015-12-09" version="1">MQRRNFRSTTLFHRNLVDYINNNQNLWKAEINKRFVSLKAIDLLRFLGTNRLGTNKQKIKHTAREENYYAKTEIPESFDAREQWPLCNSIGKIQDQSTCSNRSCWAIAAVEAMSDRICIASNQTKQVMLSARDLLSCCSKCSNGCSDAGDPIAAWEYWNTEGIVTGSDFASNASCLPYPFPECDHFNQSIYHPSCGPEIYPTLNCISECSENYSKSYADDKYYGFSPYLLPRNVTRIQLEIMNNGPVEAVLNVYSDFMSYEKGIYMHVIGDALGGHSVKIIGWGVENSISYWLIVNSWNGEWGENGLFRMLRGTNECGIEENVVAGIPDFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIV2</accession>
    <name>A0A0N4UIV2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1819</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIV2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIV2"/>
    <dbReference type="WBParaSite" id="DME_0000755201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000755201-mRNA-1"/>
        <property type="gene ID" value="DME_0000755201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000755201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19157" checksum="EDA53D1FD2CB50C2" modified="2015-12-09" version="1">MVEAANANSPASSIVLSDAIICDEESIEIVEISQQIIRNGGETIWLLLNREIDKADIFIEFDQITIPVESIRIYGKVIIFIIPIFELPDEKSSNYGENNAVFLRVNLQKIRLPLAFLSREYINGVCNHDLSNEETSSQINSLFDFASGGDPIVLLKPVIPLFKVCDKELCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJG6</accession>
    <name>A0A0N4UJG6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="9">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10172</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJG6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJG6"/>
    <dbReference type="WBParaSite" id="DME_0000780201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000780201-mRNA-1"/>
        <property type="gene ID" value="DME_0000780201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="10">
        <location>
            <begin position="29"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="11">
        <location>
            <begin position="296"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000780201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49696" checksum="9D98F5BF443E36A4" modified="2015-12-09" version="1">MINLIAKNKLPHFLLFILIIIIPLISSGRILLLVDNLYIKETHSIFIKSLEDRGHILTIKAADDQTLSLSKYGESLYDHLIIFAPGVDEFGGSINVREIVSFIDNGGNVLITAGNRVGDALRDLAAENGFEFDEDGTSVIDHLNYDVALDEGDHTTIVAEPSQLIAAPLIVGEGKQHAPILFRGAALVTDKSNRLRLELLTASTTAYSFNPQSKIEEYPSAVGKSTILVGALQARNNARVVLTGSLAMFSDTFINANIKKVATTESVKSGNLYFITELSKWVFMEKGVLRVKSVSHHKINQKSPPREYTIMDEVEYSIEIEELKGGKWVPFKANDVQLEFVRIDPFVRINLKENNGKLSARFKLPDVYGVFKFFVDYRRIGFTHLVDVQQVSVRPLQHTEYERFIRSAYPYYFSVFSMMVGVSLFSCVFLYHKELPKEYKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI1</accession>
    <name>A0A0N4UJI1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI1"/>
    <dbReference type="WBParaSite" id="DME_0000782001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000782001-mRNA-1"/>
        <property type="gene ID" value="DME_0000782001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720961" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000782001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12662" checksum="B32165EEAC3DD347" modified="2015-12-09" version="1">MWNRADFNLQLRILFVIFVGSQKEMSSTKQEDNNRKLLEELNRTRQLMMKNTGASGRQLALESNISRCDPRTVQLVNNLDSQTPITFIPTNSQHNNTILPVFPRFPPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJL6</accession>
    <name>A0A0N4UJL6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJL6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJL6"/>
    <dbReference type="WBParaSite" id="DME_0000785901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000785901-mRNA-1"/>
        <property type="gene ID" value="DME_0000785901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000785901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33181" checksum="438BC4065598E6D1" modified="2015-12-09" version="1">MATTLTVKVHPVVYMTIVYSYERRSNKPGANDKALGTLLGFYEKNAIQVTNCYAIPFSEQKEDTPELDDGFNQSMLQMMKRATPSEQPVGWFYTNADLSAHCLPYHDYYNRLISESSAKKDPPPVVLLTLDTTFSTVEENTRMPVRAYIRTKAGIPGSRDPHCAMFNPLKVEMDAFPGEIVALRLIHSGTTDKQREVRLENGVRHLEKSTGEMVAYLQRLLKYVNEVLQQPELPVDSSMGRRIMDIVTATATHLSEERLENLVKNSLRDYVMISYLSGLTKTQLAIQERLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJN9</accession>
    <name>A0A0N4UJN9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10233</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJN9"/>
    <dbReference type="WBParaSite" id="DME_0000788401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000788401-mRNA-1"/>
        <property type="gene ID" value="DME_0000788401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000788401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16548" checksum="7916A6D00A02FD79" modified="2015-12-09" version="1">MQGRKCGIHMIFREIQPSSSSESFSSNDKICWLRCQCENESYIREGEKCVEIQQRTAIANNSTTVGEIPIQSDSINNTRNYKIGDKIFDYGCQRTNQKCGTNMIFKTISKRRFLELTDRCLQKCSCINDEYKENNGQCIRFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJU9</accession>
    <name>A0A0N4UJU9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IgGFc_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJU9"/>
    <dbReference type="WBParaSite" id="DME_0000795501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000795501-mRNA-1"/>
        <property type="gene ID" value="DME_0000795501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000795501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45291" checksum="D502820E7256588D" modified="2015-12-09" version="1">MNGLSDSTGKTFVLVFPWNNDDDGLKESFLAVDLINHSMENITVDLYYNELEFIERDIILRPFHITITIEEMNYRRHIFSKAVVYKYIYGGFNRYPDLRIFIRSSLPINVLAYSFVEGGSVLPEDMAGKNYALTLPAPLVNSGSAIICLLPTISDTNVNLTIITSDSFENYYIGLKVEANRDVVIYSKKESFTVYANGDAPFHMIVAVQNLPVSPTSTITDFGMLMVPPTGLSTDDSGKDDTHFSHFSTTKSFLITPFAWTKSSFEIVGTNGNSSWHSVEGGRKQNTHSFNSSNFGIECAFLSRSNPINILRYGGYGLYSDGFEGGAFLDIIIGDERMMKTVYFDFALPCCFTTLEYYGKEAYYLVGSVSEGFHTFMAGGKYIIIVSGEFNNTAFGYVPVLNRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL86</accession>
    <name>A0A0N4UL86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2504</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000064">
        <property type="protein sequence ID" value="VDN52531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL86"/>
    <dbReference type="WBParaSite" id="DME_0000854801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000854801-mRNA-1"/>
        <property type="gene ID" value="DME_0000854801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830774at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000854801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7558" checksum="084FEF6F18B55E65" modified="2015-12-09" version="1">MDFSFGSKIAENYFKIYMMVNFRSIRTKSIDMRPISIPPPSIKYNEQSALEICCYITLAIITGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT7</accession>
    <name>A0A0N4ULT7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2669</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULT7"/>
    <dbReference type="STRING" id="318479.A0A0N4ULT7"/>
    <dbReference type="WBParaSite" id="DME_0000877801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000877801-mRNA-1"/>
        <property type="gene ID" value="DME_0000877801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000877801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37147" checksum="32E4CC13CCDFEA3C" modified="2015-12-09" version="1">MNSDRQLIRTDLSNPFKTIGPLENPVVENLIKRFTKGLFIDNRNIADPIVTPEFFETQQRGEIRYMENDFETPFHPNPMRTSNDSHRMLYLYGSEYLFNSLLYHAYEDDRLIVEIDENLLSPQYKSLVRTTCNEVHSDNVFKSMCLGKLIPEIEKIDQIKLINLNYKLIVELFNYFTTNNNITARLLMYVKGELRRRQILVSSAHLQADLRFIIQDEKFAAILKLNKFIARLHRSAIEGVNSDTITQLTPLAKTFIGPYLARALRKGLPFPLKDSVRFINPVLRIHDGFAELATDFRLGERNLREKIKKAFNENFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMP3</accession>
    <name>A0A0N4UMP3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2866</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMP3"/>
    <dbReference type="STRING" id="318479.A0A0N4UMP3"/>
    <dbReference type="WBParaSite" id="DME_0000912901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000912901-mRNA-1"/>
        <property type="gene ID" value="DME_0000912901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000912901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38633" checksum="4A7FF60A9FF38C0E" modified="2015-12-09" version="1">MNADEALDASKNEESSSTILFDQLNERHSNSPVEKNQYDLTEYEDDTDCIELIHCRIDEIPDFSRFKNLMDLSLRQNLLSSINQNMAITTLTKLELYDNQIERRLQQIENLDALVNLTSLDLSYNRLHSIQGLSKLINLRSLYFVHNKITAITGLDSLRSLELLELGDNRIKKIENLDNLTNLRQLYLGKNKIRCIENTEKLINLEVFSIPGNRLINLDGISIHSDLREIYVSDQRITSLLPVKDLKNLTLIDASNNEIEKVDGVCDLPLLEDLWLNDNKIDDWNEVEKLSGIGNLRTIYLERNPIYHKDRTSYRRKIMFTLPQVTQIDAAACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMU7</accession>
    <name>A0A0N4UMU7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2931</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000090">
        <property type="protein sequence ID" value="VDN52958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMU7"/>
    <dbReference type="STRING" id="318479.A0A0N4UMU7"/>
    <dbReference type="WBParaSite" id="DME_0000919401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000919401-mRNA-1"/>
        <property type="gene ID" value="DME_0000919401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5773536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055987">
        <property type="entry name" value="DUF7565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24446">
        <property type="entry name" value="DUF7565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000919401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32226" checksum="8DB9A607CC2C296D" modified="2015-12-09" version="1">MYRCALCTTVSLTYPSIEELEVHIAADHVNYVPYECEKCRFSRYPTEFALISHYTNDHCMKEFYVKYKVTPDSERMRAQIREILQQYSFYSLFILFCEIKANEIINIYLFFKLVAAGLTDTLVCDGNSMFDASVKGFENASDIGQPLSPVKKKIRPPRTCSLCGLQVTGQRSSLVYHANSKHLRVSLFFCRPCNKTWTTVTKSDIVKHVKAVHDGDESVIEDYRTQYANEIRQITDKCFPPRHRGPFYHFLCVYLNQSVFNEFYQWIFVCFRDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN57</accession>
    <name>A0A0N4UN57_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3047</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000100">
        <property type="protein sequence ID" value="VDN53074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN57"/>
    <dbReference type="STRING" id="318479.A0A0N4UN57"/>
    <dbReference type="WBParaSite" id="DME_0000932501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000932501-mRNA-1"/>
        <property type="gene ID" value="DME_0000932501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000932501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42570" checksum="635E66B99777371D" modified="2015-12-09" version="1">MIRAIISSFVWLFGIRAFIISFTSDFIPKLVYQIVYNHDELYGYVNNSLSYFDISSADYKLNNIVTGNITTCRFRDYRQPPCTVSKSEDCNYNYDLTIQWWVVLAFRLAFIIIFEHVVSAIKSFVAFIIPDIPSKIFIQLQRQKFLSRQARLLDLSGNNEIQSKFSGNIISSDIGTKIKERNIAFQPDLFGTNDQTISQPFKTVMRHESLRNITASLRSTSADSFCSCYDDRTEKDLKGFNLFAFILVQKFWKSSMSIKIYQRRLSPHSHCLNSHRLNLQYSYICCQCRLLYANRQRLIRRNYYWYITQKAERIKKRQKLMSVDRLAPLDAICVILFQTASCDEIRQALINYDQSVHHPEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNH2</accession>
    <name>A0A0N4UNH2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10668</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001234">
        <property type="protein sequence ID" value="VDN60695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNH2"/>
    <dbReference type="WBParaSite" id="DME_0000945401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000945401-mRNA-1"/>
        <property type="gene ID" value="DME_0000945401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839342at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000945401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27263" checksum="3A54FB2E0057245A" modified="2015-12-09" version="1">MSKKLINFVFQVLTASVMLCNILGALCIVLNFFIIIMLIRNRNKVLSNVFYVIVLHCAIVDLIRGCCLMAWGLPHLLMNKKPTMNDRLLALKVAVVLQERYRISIQINQFALVILRSCNLLTIFNLLVFTTNEFLVIQHPLYYRRNFRRRAVLILFLASWLVSLTFGIGSVFSNFFESAHSVLVFNNDTSIDYRNGTIGKFFCISWTEMNTKVINLYAYNPFIKIAQYFLLFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNX9</accession>
    <name>A0A0N4UNX9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS3291</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000120">
        <property type="protein sequence ID" value="VDN53318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UNX9"/>
    <dbReference type="WBParaSite" id="DME_0000964101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000964101-mRNA-1"/>
        <property type="gene ID" value="DME_0000964101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422368at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160110" description="GDP-fucose protein O-fucosyltransferase 2" evidence="19">
        <location>
            <begin position="18"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN53318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000964101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49755" checksum="925DCC1AEE6C1632" modified="2015-12-09" version="1">MIGSLLILLLFTKNIETNSFVSILNGDYSIAEVKYILYDVNHGEGFNLRRDVFMRIANTVRMLRELGHNYILVLPPWGGLYHWKNYAVKLPWSKFFDIKSINEFIPVIEFQQFLIDTNYNPIDEVIYLQAYTEGWKSGHFEFKYDKRDCIDGEKFYRLVGSKWHGWFFSYENITAKSFSCISMQGDSQTLMKFVVNDHLIAKSLFIDRAEIILHDYFGDEYYWQARRSMRYANHLITTGNLFREKYLNSSDITDKTALNDTWKNTFKKHGEAQGGDYICIHWRRRDFIRSHLSHIPSIQGTALQILKLLDAMNLNTVFLSTDAPNDEVNHLKSFLPPRIEVKQFVNNDSLSDGEVAIIDQWICAHARYFIGSYTSTFSYRIQEDREILGFEPNTTFNRLCPDDSMSCEQPTQWKIVYKNNVGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ34</accession>
    <name>A0A0N4UQ34_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3622</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000159">
        <property type="protein sequence ID" value="VDN53649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ34"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ34"/>
    <dbReference type="WBParaSite" id="DME_0001010001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001010001-mRNA-1"/>
        <property type="gene ID" value="DME_0001010001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5801741at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056017">
        <property type="entry name" value="DUF7596"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24524">
        <property type="entry name" value="DUF7596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7596" evidence="1">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001010001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="411" mass="48084" checksum="B551AC1007C40496" modified="2015-12-09" version="1">MLAASHLQNFIQNTKCDKILDGHLFPSNNNLAFISSKDIAVVTIVEEIGDNYKLVALGALNKCNNNQYLLQIRPFVTVERILSVLIPMHIALMKLITFISRIFRLEASFREDCSMLQNVMAKGYLMIKKCEETYLSRSVSIESYTNLENGLEDRHLCFKIKEVYDNDANYSGLSPYYAVFEDREHQNVLTHIYDQLVEFSLSTMNMDLIKNITVDIEESENFYSNQNIMKIWRDKIGMIVADKYKYYEIEIERSVFMQITNGPKNDYSKINYEEVKPSNQIWVYDYDSTITLFSRENHIENLLKINEIKGVVATEFGQPRGYILALNNRILQCYADSTNIAKGLLNNLMMIMHVNSIKMFIMGNKDDNWICDELLTKAIYIQRIYRFHSRILPNRIKWEKIFLLNIEISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQB7</accession>
    <name>A0A0N4UQB7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3706</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000171">
        <property type="protein sequence ID" value="VDN53733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQB7"/>
    <dbReference type="WBParaSite" id="DME_0001019601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001019601-mRNA-1"/>
        <property type="gene ID" value="DME_0001019601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025519at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001019601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24196" checksum="FB910D367F2224B1" modified="2015-12-09" version="1">MVNLPTILQIFSFIFILCGSIINFIALATPSWQVVYARELQQWIKSGLWMNCQTRPSGMLSCAYTFSKNDINIYTGSDPINIRTPAFYEWHHNLLYLILLGQLFALLGMISFCLSQAVAIRKKAMILLSLLNVGSNLAFLIYANMVEYRFYHVSVSGIYEKHFGFSYYLHLLGSIFLLFGLLFAIAFIAFFNRLNNTERNRMLYSPYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR28</accession>
    <name>A0A0N4UR28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10913</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001273">
        <property type="protein sequence ID" value="VDN60940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR28"/>
    <dbReference type="WBParaSite" id="DME_0001049601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001049601-mRNA-1"/>
        <property type="gene ID" value="DME_0001049601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160401" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001049601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14727" checksum="9F62343976865F6C" modified="2015-12-09" version="1">MAVFTLLLVLASLCHFANGGAMTIDVCSVVVVAGQNPVRRPSLPVENCQDRDPPACFEIFKYGNDEDQIPAENLVPTNDYKVPENCQKAEYRMLARQMCPQKCATCCLTKEYNCQNGNSFWCNLRLIYPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URD4</accession>
    <name>A0A0N4URD4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division protein kinase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4034</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000255">
        <property type="protein sequence ID" value="VDN54061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URD4"/>
    <dbReference type="STRING" id="318479.A0A0N4URD4"/>
    <dbReference type="WBParaSite" id="DME_0001060901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001060901-mRNA-1"/>
        <property type="gene ID" value="DME_0001060901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07839">
        <property type="entry name" value="STKc_CDK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000184">
        <property type="entry name" value="cyclin-dependent kinase 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0001060901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33363" checksum="AA064A12DC16B10C" modified="2015-12-09" version="1">MQKYEKLEKIGEGTYGTVFKAKNVETQEIVALKCVRLDDDDEGVPSSALREICLLKELKHENIVRLYDVVHSERKLTLVFEYCDQDLKKYFDSCNGEIDQQLVKSLMYQLLQGLFFCHTNNVLHRDLKPQNLLINKNMRLKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYDTSIDMWSAGCIFAEIANAGRPLFPGADVEDQIKRIFKVLGTPTEQTWPSLSQLPDYKPMSVVYPSVTFNQVVPNLSATGRDLLQQLLVCNPVHRIDAKTALRHDYFKGFIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URG2</accession>
    <name>A0A0N4URG2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4063</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000266">
        <property type="protein sequence ID" value="VDN54090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URG2"/>
    <dbReference type="WBParaSite" id="DME_0001064201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001064201-mRNA-1"/>
        <property type="gene ID" value="DME_0001064201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001064201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35348" checksum="8BD683393FB5BABD" modified="2015-12-09" version="1">MFFGFLLLLPIVNGQDNGIEFVLDVGCKLNCGSNMTFITAEHYKFRPNLSTNLLANKICMQQCMHISLQAMKITETRATKLTTTISLPNTARILPSTLGRDYFGKSETIVDVHCKLTGAKCGPNMKLITVKQRYQFRLKFPKNLSFDKSKCAHLRFCTLNEKIKDYTCKLTGKKCGENMKFITVNRIEPIQFSIAFVLFKFCIQQCKCARKEYIEKDGKFGKLVDYRFVPLDEYDIPFQINRVAYSYGEEVFDFSCQLAGSKCGLNMMFVNIDPYKSRFAYPQFSSSVFCVVQCECIKPFEEKDGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URN4</accession>
    <name>A0A0N4URN4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4122</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000308">
        <property type="protein sequence ID" value="VDN54149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URN4"/>
    <dbReference type="WBParaSite" id="DME_0001071601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001071601-mRNA-1"/>
        <property type="gene ID" value="DME_0001071601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001071601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27995" checksum="955892347420AAF1" modified="2015-12-09" version="1">MLHLLGNPADIIFFNPALEAVLPLNPIKAILKCGIEMNSEGRSVIKNLDQELSPYLVNRVRYCFFLACAAFAKLIDIFYGDFNLSIDFKESDEFLRLWSEANQNAQNDWQNQQQVMTQSSSLITADSSTLIASQLTFSNGIGGNFLKNALHGSSHSSKSRATSDRSIVAPVPSLQTNIDDIPLDVAKPDSCQFVWHYLHSNKAQDPFIGEHQPKVSRMLDLFMDWLVKSALVRPSRYSSIYGIFYQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US60</accession>
    <name>A0A0N4US60_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4284</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000590">
        <property type="protein sequence ID" value="VDN54311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US60"/>
    <dbReference type="STRING" id="318479.A0A0N4US60"/>
    <dbReference type="WBParaSite" id="DME_0001089201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001089201-mRNA-1"/>
        <property type="gene ID" value="DME_0001089201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001089201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1073" mass="114102" checksum="B00F7C56F91474DF" modified="2015-12-09" version="1">ILPTDKNGNYRYPQLASDGQPLPTDIHGKPVYPVVDADGELLPTDEAGAAIGLDGMPIPTDNSGRPIGEDGSILPMDPYGRISLQVISTPKILPTDDRGHIVTPVADLHGHIFPTDSNGLFIDPQGKVVPTNQDGQPTGPDGQVLPTNELGYFVYPALISDDQLLPTNLYGKPVYSIKDSEGKFLPTDSTGAVITRDGRPIPTDIAGYPISSDGFPLPSDSSGNFIINEEEMEKILSKEKIRTTTPFTIIGPDGSPFLTDSYSQITDAAGPPVGSDGRILSSDEPGNYIYPGGYKHIYQVIGPDDQLLPTDSTGAILGPNGFPLPTDSFGRPTGNDGSPLPMDSLGRFIIMKKEEKPKNLPTDESGHTMVPIFGLNGELLPTDSEGFFVGLNGMPVPTNELGLPIGPGGDILPLDENGNYKYPPFWSDVHPLPTDSRGKSIYPILGPDGQMLPTDKTGAVTGLDGLPIPTDLFGKPIGEDGSPLPIDPFGRSIYTHSKIRVLPTDDGNRFRTSLGGPDGHILTTNSKGLFIDLQGKVVPTNQGGLPIGPDGRVLPTNGLGQHFYPILIRDGQPLPTDLYGKPVKNIGEFFPTDSTGARIMPDGRAIPTEKSGHPIGSNGFPLPTDSLGNFIITDEKMKKIPKKQKGHTPPFAVIGPYSWQLPTNDAGEVVDLRGEPIATNAAGRPIGPDGKILSTNDSGIFIHASADLNGQTMTTDVHGKLVYPVIGPDDHLLPTDSLSGVVIGPDGLPLPTDSVGRPVGYDGSPLPQDSHGRFVFMKKKEQPRILPTDETGHIIIPLFGPDGQLLPTNMQGHFLNPNGRPVPTNELGIPIGPDGNILPTDESGNYRYLQLESDGQPLPTDIHGKPVYPVVIIDGQLLPTDEVGAVIGLDGMPIPTDNSGRPVGEDGSVLPVDPYGRFSLIQVKSTSEVLPTDGRAHILFPVVDRHGDIIPTDSSGLFIDAQGKFVPTNQDGLPVGPDGQVLSTNELGYFVHPVSTRYGEPMPTDSNGKPVYPIRDSEGEFLPTNSAGAVITRDGRPIPTDIAGHPISSNGFPFPSDSSGYFVITEEELKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USC1</accession>
    <name>A0A0N4USC1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4343</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000866">
        <property type="protein sequence ID" value="VDN54370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USC1"/>
    <dbReference type="STRING" id="318479.A0A0N4USC1"/>
    <dbReference type="WBParaSite" id="DME_0001095301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001095301-mRNA-1"/>
        <property type="gene ID" value="DME_0001095301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852176at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001095301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8751" checksum="8B6CC4825EBBC3C2" modified="2015-12-09" version="1">MIGLTRLPSGFACAVSIRRLETRQKFITGRLTWIFAIIAFLFFIPLAAVPFFIRPCKDVLHHCPNCNTLLSIRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2W2</accession>
    <name>A0A158Q2W2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5297</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2W2"/>
    <dbReference type="STRING" id="318479.A0A158Q2W2"/>
    <dbReference type="WBParaSite" id="DME_0000093701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000093701-mRNA-1"/>
        <property type="gene ID" value="DME_0000093701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="226"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000093701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47776" checksum="378C3E5F7BC1986E" modified="2016-06-08" version="1">MDFDFMPKGMMNDDGSADDDGDDFRLICRKMKTERTVESSDPHEIVIDPVQFCLSACKWRWSTFPLFFFFLIFYWSCGIGEQPLASKQRKNTDYNILANHCQCLIDSPFIHEIFTKYFENIFNSSGEHHSTLIKYIQYVSRKVSSEDSSSVTQCFVLQKMSEIARRLEAVILKMSLMDEKWRKWDKEYKIKKINERKTVEEAVRAAIDVYDADKTGLHDFALESAGGTVLLKKCSPTYENAWRYQKYLGIPFFQETISPRIVIQRRVGPSTGDCWSFKGEVGRFSVRLSHSINVTSVSYEHLPAQLSADGSVSSAPKVFQVWGYDDEDEMNTRRMLGEYQYESTGRPLQFFRTQVSNWVCLHTHLAYPDFFCYRSILIPKSLSAESDLPNALKNGVQPVASQYDRLKYLYATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2X6</accession>
    <name>A0A158Q2X6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5435</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2X6"/>
    <dbReference type="STRING" id="318479.A0A158Q2X6"/>
    <dbReference type="WBParaSite" id="DME_0000107501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000107501-mRNA-1"/>
        <property type="gene ID" value="DME_0000107501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874995at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055472">
        <property type="entry name" value="DUF7044"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055473">
        <property type="entry name" value="DUF7045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF4">
        <property type="entry name" value="CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23071">
        <property type="entry name" value="DUF7044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23073">
        <property type="entry name" value="DUF7045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7044" evidence="2">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="1">
        <location>
            <begin position="154"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7045" evidence="3">
        <location>
            <begin position="267"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000107501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38712" checksum="21C78AF19904EA33" modified="2016-06-08" version="1">MRKLKMQVIITSTSISSWGNCYERVNDSYIFGMKKFGKSLCFRCITLVQRSANIIQAAHQIGNPCKNSFSEAKETCFDSSIITYTEGTFLYSKQIFLIKLFKNRIKKTFHISLRNQENFREMQKNKSLRNLFVNKSLRNGISIFLLGMDHESVGKCYFPEWLIGEYDSLQITQRSLIYSPNIADSIPTISHCFNIDEHGIVVFSESLCGNAIGYHCLWFRDRSDYVLEFKTSDKQDTNDGTICRNERAFEFSPWVVITTKDPDSAPCGYEGQFTTPKLYEDFGCYNMIIDCSKNHSISAREYKCLASWKEDDITFIYTKLAFMQTKFCIVSCDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q339</accession>
    <name>A0A158Q339_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5918</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q339"/>
    <dbReference type="STRING" id="318479.A0A158Q339"/>
    <dbReference type="WBParaSite" id="DME_0000155801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000155801-mRNA-1"/>
        <property type="gene ID" value="DME_0000155801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000155801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57096" checksum="D172F7CF3819D7C5" modified="2016-06-08" version="1">GKNFSLHYYLLHISAVQFPISEKLTVDDIYDRRTGKPKTDILKEHFIKEGRVHEDVALRIITECTAIFRQEKTMLDVEAPVTVCGDIHGQFYDLMKLFEVGGSPATTKYLFLGDYVDRGYFSIECVLYLWALKIIYPTTLFLLRGNHECRHLTEYFTFKQECKIKYSEKVYDSCMESFDALPLAALMNQQFLCVHGGLSPEIHTLDDIKKLDRFKEPPAFGPMCDLLWSDPLEDFGNERNSEQFSHNSVRGCSYFYSYAACCDFLHHNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELMADSDDTFEGGVPSARKEVIRHKIRAIGKMARAFSVLREESESVLQLKGLTPTGNLPLFTLQEGRRGIQEALSGLEPGHRIQSFDEAKRLDKINERMPPMAATSQPPSPLANSSRRTSSNLSNSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3L3</accession>
    <name>A0A158Q3L3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="24">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS7003</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3L3"/>
    <dbReference type="STRING" id="318479.A0A158Q3L3"/>
    <dbReference type="WBParaSite" id="DME_0000264301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000264301-mRNA-1"/>
        <property type="gene ID" value="DME_0000264301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000104">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055928">
        <property type="entry name" value="Fmi-1_DUF7505"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24337">
        <property type="entry name" value="DUF7505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2270"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2299"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="264"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="359"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="471"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="575"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="676"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="777"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="884"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1241"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="1321"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1537"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="1580"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1740"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1782"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="19">
        <location>
            <begin position="1900"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2455"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1767"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1804"/>
            <end position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN57030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000264301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2501" mass="283574" checksum="7DAF3296DD8ED729" modified="2016-06-08" version="1">MILHRSPSTFFIYLFFGLICEKFLRIASQKIINRLPVVSDYSCNPCSTPIDNITIWLLFSNSPCFHPGQALLLWNTTKCTSPENLNSEDISFDRNIVFVKRRICFYSYNLLINYQYSCSSDHPIRHGQFYVAHPRYSNARRSKRWLIRRTTSITKIHFQQERYFIELPEDMAINSLLLIVQATHINNRSLFYSMIAPEDSRSINVFMLNTITGEIRLGKSLDREILPKHTLKVTAYERLDPSVSSSTTVVIDVVDVQDNAPIFERTSYYAEIKEDVPIGTTVVSVFARDADDGKNGQVEYSLSEAVGSDLFHINLHTGVIQTAALLDREKCDIIRFSAIATDKGVPPMSSSALVEIVVLDELYNISIMENITVPAVILQVKAIDEDMSLNGQVHYSIVESSSGDFSVDYETGIVVLQGHIDSRISPVFLVIRAKDSAQPAKSSTVSCEIHVIDVNDHVRISATFHIKPRFVAWNQQIFVDENAPVGRELSRVLAIDEDAGQNGMVRYFLETNSPTDFEIDEVKGSIRIKNQLDHERCDKYELKIRAEDCGSSPLSDFIVVTINIRDINDNAPYFKQDFLNITVSEIAPRGTQLASVKAFDNDKDQHIVYRIDSADRSIFVLTDLGVEGAILSLSGEFRSTDHSLRVVISATDQGGLKGFCTVFINVEDVNSPPYFHRFPFTIHVAENAAIGYEVYRMKANDDDRGNNAKLQYFIDSTSFIINETTGAITVANELNRELNDTYILNITVRDQASAPLSSTAIIEIIVDDVNDNAPVFSSDNYTVWIPEDIPIGTSFIQVFASDADIGENALISYYLEENDYPKPDAFIVDRSSGVIRVDKKLDREKIDKYVLTVKAEDRGNPPLYSKSTIFIVLVDVNDNAPQFELPKYDFWIAENSPVGTKIGTLVASDIDEAENSIIQFKIFSADAKFFDIETEFSKNGIVHLISRIEFDYEARKNEFFFEIQASSGQLSSTVPVFVHVSDINDNRPQLRDFITLVAHYRDEEFNPVIGQVPAFDPDYNATLEYYMETNEIISIDKISGEMRLMNVWNRHIDSEYTTCVSDGPNVVCAKCHFIYVPVDENALLESVTVNLYDLRHDELLDYAIFQRFISAVSLLEQWRPRDIRVFNMQSKGFNTNVTFYVLHNGKIERSFRVRELFSNGKSRLSEISGLKMDLAEDDICFGEPCGYYQRCRQTQKYIKAQQVHRTDNFVFRSLVTVPTLICECPKGFFSSDDIQGSCDLQIDQCFSSPCEHDGKCVSLENRYHCECTDGWTGSNCEESIFVDNCLSNSCFSNSICSIANRKPRCLKCPWRIHDSDDRCRLRSISFNGNGYLAIPLSIGRISWNFRVNIATINQFGILLFAGKIKSDFVEISLENGFIRARFSLGDKIFEGKMKEWPENKVSDGKWHHLDVDFFDKTLRISLDNCDLYIFKKLGNKSSYRPCAFEIKAMFPSKCGDLAVNCHRFLDIASPIYLGGRPQRSLRNNFVNGIDDESATELVKDGYTGCIANLTFDGVLYHFSELDRMEKRGNVIAGCHQMRNECEKNPCDNTSKCIVKWDGHNCRCPHRLHQHGPCETGESPQTPLLFNEQDSYSIWKIRKGESFHNVSFEFRTRSREINVINVDFASPTQKIIFSLAQGYGMLSVGEENYMIAYPYLADGDYKAISVGIFGQTITVLIDYLYKKHFSLYDEYLYVEVRKIFTGSAPMSNISRPFRGCIRNVEMNNKALKIADLSRTKPGCHMENLCSQLAACPTNSRCIPDWDRYNCECFFGYVGDGCIDVCNLPEICNSGICRRTNNSHGYECKCRRGTTGSNCERELMQICPTGWYGRFPECKLCDCDHNKGFVEQCDKETGKCRCKIGFFIKNGRCVPCECGYGSLHQFCSAVGQCPCIGSATGRRCDRCPNPHELLDPKSLTCRIINNRCPSNIENGIQWPTTIRGVLAKQNCANGETGIATRKCGLDGIWHKASIFNCTSPLFKKLSNVEDDLITSVILRNATNMRSSLHGINSELALKALKKAIMNEQRKRANESEHLRMSYFTENILEAANNILSSNINSIDVISLLFDYGKHLLRIHSENSFLEPFFFSADNLVFVIDTVGDSHQYSLPKFDNFVDNRRNDLFLQSAINVICPSLNGKTKMLFYSMAMFHDCQYCKTIIVSIFIGGGNCETEMQFPFIEESGWKIPECVQLLFPNENITHSNSNAKSFKEIQGKYAENILLFNDFIWSSDDSKLLGLNRTHVVCGYHNSGIFSVFTTPDHGALLHFMNSDTIPYAGSLSVAFALFLLVISIISVLYRRINFKIIHSAFMVSFLLDAIVILFLQRVRHNLLDFYSCATAFIISYNGDFNLPTTKRYMLKTLLLHSSLVRFIPLANHAPNNNVLWVANEPISPKEPSKQPCQTPLLSSTTQFESVVADKDESMQWMPDVIPFEQYVYQAGIYNSLPHPAILSPPTKVLHPESVYGDSGTADEHSSPRFTHSNRGEDLRHIYDIYYNKHYHSCSTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Y8</accession>
    <name>A0A158Q3Y8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-catulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7575</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Y8"/>
    <dbReference type="STRING" id="318479.A0A158Q3Y8"/>
    <dbReference type="WBParaSite" id="DME_0000357001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000357001-mRNA-1"/>
        <property type="gene ID" value="DME_0000357001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9933814at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000357001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70586" checksum="1A39EA1A6640A522" modified="2016-06-08" version="1">MSLQTAVDGSIVSAASTTFNSVRHDGSNHYGFDPRNLEIKTKSVEQTLVPLVTQITTLVNLKENFLISGKHRSDKALRSALKIGSAVEAAIERFVAVGETIADENVDIQPEMYDACHEARLAGASIANLSGCLIDDSNVTIDKSVLVRAARQLLSSVTRVLLLADRVLVRHILRAEDKISFSLVKLENTSNFTEFVKIFTEFGGDMVDLAHRSGDRQNDLKSEKRRGQMAVARTMLERLTMLLLTSNKTLLRHPENESARQCRDGVFHQLRLALQLIALCVTDGIMQFDGAHFVQPSNEEVLDIGMQLTANAAMKQLMDLLEMVRMTCNVGTGTRERLVSALDSLCEMTQDFTDSAYTPHHHREQILDFLEECRFEMTNLIQPESHDELSRSDGIEVTVERLNHRLRDLRKQLQIVAMEQISEILRTSDDQSILSSIKTCSVSGDIDGVEKYLVKFQEHAEHIQEVCRLLHHISLSDWLHVLTGHAERNLRAFTPLTVLAGRSLCMHPSSRIARENLEVFCDTWSQCVNDLSRLAKETDAAVSGRLAAEKQAYMSLPRPGVSYGPNFLNSSQSSMSPSPPSDFSFDSNRGIHSTQTSDNSNGRFVSSNEILLGKYCISLIYRMKAFFFSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q409</accession>
    <name>A0A158Q409_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7738</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q409"/>
    <dbReference type="STRING" id="318479.A0A158Q409"/>
    <dbReference type="WBParaSite" id="DME_0000373301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000373301-mRNA-1"/>
        <property type="gene ID" value="DME_0000373301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="4">
        <location>
            <begin position="365"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000373301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1805" mass="204426" checksum="58E5AE824E1EF09A" modified="2016-06-08" version="1">MKTADMKTSETPHNAWKVPSPIFKDQLEKGGKASALRPTLSISPSHTVLMQLSRKHKSDSFYQNKHKMTFEMMQRIFTAPHDFQEFLSKDENVLEAISDEGLFEAARLANPILPQYHPKQLIELLNSGRIREVKAILLHVLKCLKHSIASSVPNPLSSSSSVRRISMSETVDTMIAQQNMNQEESRRGLSDTFDDINSEYAELDSIAPLPLYLLMSVDDFSVAEGRTITCGNEDQYNSLFETGQNNDDLDEMLNMDNTDSDTRHSRQPSMTSDVALANTGILKDQISTVFTAKHNRILTELLTHIHLPGLSTVDQMHLLAIADTISHFSADAMDKLAQANAALNITQVRVLNDAGSGYAATARGIESVDECGLRFLMAMKQHEYLLLCLPLLQKKVLKQKGISSSNIIWALHSETETELLNAIPSLHKVNLCWEDLRSLGIAWWLKNTSSLKVVIEKLAKSAFQLHQNPMDASLYYMAIRKKNVLTHLFKTIKDQKMADFFMQDFAEERWKKAALKNAFVLMGKQRFENAAAFFLLAGSLNDAIILNKLNDLQLAMVIIRLYENDLEKQCAMMRQLLCHEILGINDGNNANKCCSVDSPKASRDPFERSMAFWHLKEYSQAASTLLEEGSKDHFECPADCSLSDIFNFYIFLRNHPLVMRQKLADVEVQVGLNEKFLVIAKHVKAYVTPNERRLYFRTASAHLVSGCPFLALNVLKRLPKEMNLVEPDSSSLLNLFSGNKNSKIKRDTVENFDWSAPSRILKDDDLELEWSDDDRDNDVLSNTAKENGNVQMNNQRINFVEPLISQYTFGVFTTDYKIAKHDDGLLMQLCRGRYKLLQESSVNSHLDVIAQHMKFVAILRILVQELSTLASGFEVDGGQLRFQASSLIFKWLEKEIDVLKDLCDSETVDNGIIFDEWEDVDDSYDDLSSTNMPLHEALHSDHLQLAIRTKTTLLRRNWLNKNQKLIRAFTLYCTLHSAQNPRLTSALMELLLLLLEIQQEPMPVLSSFPLLMASVSSNKMFVSSPLRFLNNQCSDILLSLAELEEPPRLDTSFGKIYMLYSLCQGLSSCLYQSLCDVENFCQSWTNQSLGILTRRPRFVSSNENLVVTTIPSKWPGVDSLVALLCREKGEETSHLRLLLVQVSTSLFVYAFTAYDSRWLYRLAAQSIDSKRFASIFGGGGEKRMKAAQPIRPPKPEIVHSSTKNDEISTEEKTSDSLAFRSKYNAKIFGSACVTANVSFHPNVSSVMCPSEQTVYRWVAPKKNIVQMFAEKPNMETKEELGFDYDSNDEISADVDVNEDENGEKKKVIENNNPESFSWAIMRLALVQQHLYRLKQFVTLAGFDLIELPAVSPKVNSIFVLLESWGRQLVEKLSTYPTSCAVELLPNSALDQTDNHLGPLLRKYRVLLEPRNTPFECDDRIMLPVRRLWSYLVRQNHLMQIFIRHIFRRKEEEEQLNAKQEGTIVDNDQPHEVYKIVQRENEPITAFACSQIKPNWLVVATTRELQELDISSLLNCYQNIQSSSWLNNRTELDISLNELKQDVVKANDDYQLLIDDGRKVSSTNFLLKRHVTGIRRMDSHPSLPYYISGSADGSIRLWEWGTGQPLFTPRVAGQYAKNQKCHSKSASDVRFLDSSSSVLVTVGSGSSDQNVCLWDTLMPQSKALVQSWTAHPEGAASVLYFPSNQTIVSGGRRGEICFWDLRQRQLRGTLKAFDSSIVKCLITDPSNEYIIAGSSEGDIIVWTNEVAPQLHMKFSGEHANRVGFSLRQVASSSVQGVQQLYMDSQMRLFSCGGDSSLKLRQFGNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4D8</accession>
    <name>A0A158Q4D8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">39S ribosomal protein L28, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8522</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4D8"/>
    <dbReference type="STRING" id="318479.A0A158Q4D8"/>
    <dbReference type="WBParaSite" id="DME_0000463901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000463901-mRNA-1"/>
        <property type="gene ID" value="DME_0000463901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000463901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="36458" checksum="BCFCE9B93D106EB3" modified="2016-06-08" version="1">MSLAKNLRPITSAKPREVVTWDQFERIRRNKEIWDNPESIVHRLPLHYKKRYWQNVLSKAKPVHYRPPANRFSWDTKRLVLHEHEEYPIIGIHPPEADQALWGGETVVKGYIESNFYLKKKILPRRWIPHFFFPTLKYSIQYSEILDKYMKITVTERTCRLIDDHFGFDYYILETPEIDLASKLGNKLKRELLIALAKEDYYHNDPDRHDYIRRKYAKFVIPLDEAEWVGLDLNEACRKLQDLEDSIAPKPLKYQFEKDLVENIIKRKDVVIEEEEYAPKKTESLFGEKLLGKFFRPIEKALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4U2</accession>
    <name>A0A158Q4U2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS761</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4U2"/>
    <dbReference type="STRING" id="318479.A0A158Q4U2"/>
    <dbReference type="WBParaSite" id="DME_0000571601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000571601-mRNA-1"/>
        <property type="gene ID" value="DME_0000571601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865776at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000571601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23532" checksum="51C67380D3DF50E1" modified="2016-06-08" version="1">MVEGKWYSIVGYMYMNSNSGAFSIWKSRKRMFFALDESENRLQKSPIGTISLVNAACTTIDEISTAISIRVGGKNYEIIAENDSCAEKWLNALQNRRDGLDQNQNIRKDMCSECINDMMSRSRSTSLPVCSFNQRHQNEMNDQLSVNDMFSDRLVSNYKSDPHGYFQQSPINRYQKSCKRKFTDNFSDFMLHVKISQNCFGNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q531</accession>
    <name>A0A158Q531_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1237</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q531"/>
    <dbReference type="STRING" id="318479.A0A158Q531"/>
    <dbReference type="WBParaSite" id="DME_0000634001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000634001-mRNA-1"/>
        <property type="gene ID" value="DME_0000634001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000634001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68981" checksum="72222567D41425A5" modified="2016-06-08" version="1">MRLACCGVAACRSPEPGNSFVKCACISGLLDASGSPTGMFGLRTFDLLTNSCSLNNAESVRQLSLHARLAEEKYVKYRSLCDELKLSYARLAKTLKESEDQMQNMRNEFEERLESERHQREKDRKDNKARFDSILAFFTSASQIRPMCELENAAIVKKTLVDASTEICGVSAINEDVNNIWQVKKECGVQAVVEEADIQKFSVSQISDSVQIQISHFDQIMEEKSRFENQNFFLETQLKLAKNKLSQHELKQAEKLFLENRLVILSDTIDNLVKENERLKELLAIKSMNIEGSAEIYQDVNKSSQDHTNLLRNSRSIVNLNIEYQAKLDALNSELNLKNRKLEEQIQKNNNYDVNEMMSIMMSMTSGAAEEFWYQLFYRRFRGLTAMATESKRDVTLNMETATRIGNNLHIETSLQISTMSMNYETLKNEHELFKQSCESKTNAECGVNNENNNASIEIIRKYEMEIAELRELLEKYEASSETTKILHYRSNPLDLAHKEYQEFQLTKKRRQEISHQDLDSSIRQKYHDELIKQISDLQYQLHKVEKEKSSALLIQSDLVKKYRAAATALSGFQIKLKEDDLVQKVNPAVKSLEIRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q533</accession>
    <name>A0A158Q533_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1246</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q533"/>
    <dbReference type="WBParaSite" id="DME_0000634901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000634901-mRNA-1"/>
        <property type="gene ID" value="DME_0000634901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872406at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250212" evidence="1">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000634901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40125" checksum="135774EE92BF23FB" modified="2016-06-08" version="1">MFRYIFVSVIVFVVEARMCIDDIKGICEANDIFGWCFHDKVTGDFNCDKNNFCSDQSQIKGKINSTGCFDRGANDAKCCCNEAILVNIAVLEYNNYLSVNNKANGMVGIRSKIRGYTSILPSKMLKCPLDLIKSSEYFPKTYLSLFILINVPSKFSPVIILREMCNYNFIRIPPFLNNFSTQECKYLYAKEDGTILSYKNCIDPWCFTFMTANLSEPPNVVLRGCQSRTLSKMLKDANTSARSTNGVYFDDLVIFLNQTRCDAIVGSLPFVNGTQKACINVQFMYNELPKRGKLCCCRGMNECNEEFAWSHEIRILDKDENNSGLKNSFCLNTFLNILTVWLVYSFDGFNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5F3</accession>
    <name>A0A158Q5F3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xpo1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1677</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5F3"/>
    <dbReference type="STRING" id="318479.A0A158Q5F3"/>
    <dbReference type="WBParaSite" id="DME_0000720601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000720601-mRNA-1"/>
        <property type="gene ID" value="DME_0000720601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="262"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000720601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1045" mass="120314" checksum="D8B54CCCF6EC23CF" modified="2016-06-08" version="1">MTDINFGKALEAIRIIYDPLANNNLRLEAYQLIESIKEFETAQVQRFVNYLISLDDVILNHVDSRISIRNECFKLIGLRLPPSTAACRCIVSMIKHEWPQNWPELFDQFDQIARLSPLHVQIPFAVLEQLVEDVIYIRSIDNPSRRKDINNGIGMFLSQIIRMVLLALDQCALNYFSDHLAEYIPVAQSAISLLSELVEWMPSKTLELYIDDITARCIGRIASRKHIKASENRIIRALFSDFSMKSILTSADIAANVSAKREDHYLYLKALCEALSSLGIHLSEVWNGTPPNFSFYLSAMEAFFCHPSVHLRRAASDVYVTFTAQPEIVSEQLFDESFSRIIVQIPILINKPDFDSPDSPALIYSQIDYDGIPELIQELRKFRERAMQLLRYACDSKHGEIVNKITIDWLQNRCIGAIESVSEAEWESMLRVVRINFSGSYVAQLLDFGESQIFVEIFDRITLLLDKCSSVFICNFLVSILSALFVILKLHPDHVVSFLNQIRKKLLYENWDEVMDEKSIKRHCFSILMRLLTSYSDIIKNYAQNIFDICVEVRPYVSIMQLSSLTQVLAELSNLCPNYDEQTNFLASVLHEPISFFKSPEIISTLQSDLDFLNYYGFTEAAPQTMEALVESPFLKRCSMLRSNLSMISHVLSNVRSLEPSKHPVFSFIQPILPNIFRAAARIKSLHSAQSIALIHSSYGPNIFDITYAERLQLLNGIESSDQMKNKDDILHNSRNFFFSLHETIQTIVALMAQKMKKYLFMEPQIGEWSLALISGAAECPDFRIRYWIRRCWTPFLCSCPQSVYTQIRPFMLSLASELYSRLSKSWEKLYEMYRAEESPSPEEIFAEHVISFVTREVVALLHEFFGFSDKDDEKKDSVNCDLLALVWDDREVLEAYTSLSFLCLACNDSAASYRVIPICKRITDMVKEKHYFDMAPHLLIRCIQGIQHDNCEVLFHILQQVPECTADMAHSFDSQIRAIKIAGEEPTDKMKRQIMKKILQSVIAVDIGNQHRRPVRWRHLSPIPKIHKVLEEDFTALGLIFDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5H2</accession>
    <name>A0A158Q5H2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS1732</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5H2"/>
    <dbReference type="STRING" id="318479.A0A158Q5H2"/>
    <dbReference type="WBParaSite" id="DME_0000737001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000737001-mRNA-1"/>
        <property type="gene ID" value="DME_0000737001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="17">
        <location>
            <begin position="1398"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1162"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN51759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000737001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2044" mass="234597" checksum="673970D6A78EC9E0" modified="2016-06-08" version="1">MEIDIAPEQESNREQRLEKIRFTEQIDMKFGFVRYIDAEKRYAWLLNVESSEMVDRETKTIIAVCDFYFIEQNGRRFKISYPFRPYLYLATLPSFEHHISSYLNKKFSGIITCEIVEKEDLDLKNHLSGLKQKYLRITFPSLNELIKFKKEYNPIIKRNQERQKNVSSYTALLSKHFGIGRPELADSETLEKIIDIREHDLPYQMRVCIDEKIFVGQWYEVVGRNINRRPSIIPYPSLIDQPDLRILAYDIEVTKLPLKFPDSSVDEIMMVSYMISGQGYLIVNRQIVSADVEDFEYTPRPEYNGPFHVFNVANEKELIKCFFDHIIQTQPSVFVTYNGDSFDWPFLEDRATFHGFDMRNEIGFYKNSAGEYKSTNAVHMDAFIGSHNLKACTKAKLSYDPLELDPEQMCIMAKQQPQILANYSVSDAVATYYLYMKYVHPFIFALCTIIPLSPDEVLRKGSGTLCEALLLVRAYCNNIIFPNKQLYQTSKLTSDGHITQSETYVGGHVEALESGVFRADIPEKFRVNPATIYELKKDVKRALHDTLALELHINVEDVMNFDEVCENVENCLDDFINRPMRLEKPKIYHLDVGAMYPNIILTNRLQPSAVVTEEDCIACAYNKSDAKCKRTMQWEWRGEILTATRGEYERIMQQLENEKFGKPPKPFHLLDREQRAKIEKQRIQDFCKRAYGKIHMTRTENRYSTICQRENAFYVDTVKAFRDLRYEYKALLKKAKIALSEIPEDDIAAVKSARNRVILYESLQIAYKCILNSFYGYVMRKGSRWFSMEMAGIVCHTGANIITEARKLVERIGKALELDTDGIWCLIPESFPENLSFTLKTNQKLVTISYPGAILNALIRGKFANNQYHEIKPDGECIITTQNSIFFEVDGPYLAMILPASREEGKRLKKRYAVFNFDGSLAELKGFEVKRRGELALIKYFQSTVFKAFLAGKSLQEAYESAAAEANYWLDVLFSKGLDLPDSELFDLISENRSMSKKLDDYGNQKSTSISTAKRLAEFLGDDMVKDAGLACKFIISRKPIGAPVAERAIPLAIFQASESISVHYLRKWTKDSEISIDNLNIRNIIDWDYYIERFGGTVQKIITIPAALQNIPNPVPRIAHPEWLENRCRVRQSDCKQRKITELFKRTPKDIEDSAKSSVGNNSNENLESANSVSTFNEWKKEKEERKRSTYVTKSTHGMQSVLLNYRRTVLSSIWQIIRISASDDKNSLNLWCLISGKMQMMKVNIPRIFYVNDHERQDTRGVLVKRILPRMRPSLNLYKYSVDEELFESSINEINRELCAMRVEGIYESQVPRKFRALLHFGCCCKTNSTSLNSLSLEDLERVVDAEYLPERSIRSIFYYEHRQDNRCVIGVFNVAASKALIAIVDKAGKLESVPNVGILYGAEKARLESDTNYSLLYKEDVKFDVELFASLKDAHRAVNKYLADIRATDFSPFFVAVQSNQSFTTLIRSVIKLNEFPLVRIHFKEPPGLFNVLDWRRVISKRIIQHYFNAFIYLQDFVELSRYLHIPLGNIPEDLSLFVADLFFSRNLLNHNYVLWASPTDRPDLGGKELDDGRIGTDWQTMSISDHPHAIINHESFETSICVELELGAVAVTALVQASRIAEAEGGTDSVGFISGSILETDSLFGRSKNIALYDEAASVSGCLKVLRLMLQECIKDIYLHKNKVADQLIVNINRWIRSPQSLLYDPAITRVVDVLITKLCLLLVAEITRLGGRVIYASSSRIVVCTQRTDLKLGRAFVDTLIQTLEKNVLFASLSINPINYWNILMWSDIRNYIGISVDEESGEELPTVRLAMAEIFPKDANCSESFRQILVGYCVLTLRKLSSVLVSILQSSKHEITMPKTVMGRDDLKNVALQFSKAIIHFISLDSDVFDAINKVESQVMRLIGVDASSDEAVWRPIGVSCTLYQLYCNSCNQCCDLEVCQESFNCQFCKSEFSSETVESLLVNRVNQLLLSFTLQDFKCIRCNSVKRDCLTEVCECSGEYILVISKDDLEFNIRVFARIAAHHKLTRLAEVCEWIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5I1</accession>
    <name>A0A158Q5I1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5I1"/>
    <dbReference type="WBParaSite" id="DME_0000747701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000747701-mRNA-1"/>
        <property type="gene ID" value="DME_0000747701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000747701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25545" checksum="ABC11921C02A8A69" modified="2016-06-08" version="1">MILTVSDDPEFQICHEVIVDNDATLSTFLNECVNNMKDYRNISLTDLLVVINGKKIIPGNKNLNEKLLNLGFSNADLVLVQKKPSHLVPSTSKQNDRTNIIADLVKAIKVPSHSKLNPNQVIARKHNLLESDIAAHSGMRILAQKLSRNGLDYTSLPCLVYVNVILVFMAQFLYSSSLILFFHYKNEVLTELTFAKSRALLVIGANQIKWRMLRQEEEGTYNHVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5V6</accession>
    <name>A0A158Q5V6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS2413</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5V6"/>
    <dbReference type="STRING" id="318479.A0A158Q5V6"/>
    <dbReference type="WBParaSite" id="DME_0000840701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000840701-mRNA-1"/>
        <property type="gene ID" value="DME_0000840701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034329">
        <property type="term" value="P:cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="275"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000840701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="550" mass="60692" checksum="AF440BF58A315C1D" modified="2016-06-08" version="1">MSSIYDEKPPPPPLRFSSSSVRDQSFVELKPLPREPMTDLECFATSGGGLRSLPTKKAKKVKGFAGKMISLPSNFEHTVHVGYDPQTGEFTGMPPMWAQLLQTSQISKQEQQKNPQAVLDALKYYTQADSHQKWLQPSNYDGKQSSLFNAYHGGGYNPLTNGSHLSSESNSNSSQSSSVIEPRSSNPPIYSPPALPDDDSDDSPAPPIPERPARTISIYTKPKEDERKDALNNALIGGQFGMSGRDASRKKKISDAEVLTKLRTIVTIGNPDRKYQKIDKIGSGASGSVFTAVEISTGAEVAIKQMNLAQQPKKELIINEILVMRENKHPNIVNYLDSYLVGEDLWVVMEYLAGGSLTDVVTECQMEEGMIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQNKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPSRETLSVAFRDFIDSALEVSVDDRFSADQLLSHHFLKCAKPLASLYHLIIAAKKSIAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PF12</accession>
    <name>A0A3P7PF12_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PF12"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="87" mass="10529" checksum="543B44F70B1E66FF" modified="2019-02-13" version="1">MKKMKFRQEGDDNIAANFGWLYHEGFRVRPCRKTFHFFFSVWQNLQLFFLLLSSNSSHHYWLSQLHIAVFMLRDTLDQFAQLLNADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNQ6</accession>
    <name>A0A3P7PNQ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNQ6"/>
    <dbReference type="STRING" id="318479.A0A3P7PNQ6"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="265" mass="30323" checksum="17C17FAE37C2D82B" modified="2019-02-13" version="1">MSGSLSIISSLLDSAVDITSGLVIWLTARAIKKRDPYMYPRGRTRLEPIALIIVSVIMGVASIQMIVQSVESILRNSVNPHVDIISLSIMIMTILMKFTLMMLCRRYNNPSINVLGLDHRNDCISNFVAIFCAWIADRYWIYLDPIGAIVVSIYIATTWFLTGKEHLAMLSGKSAKPEFINRIVKICMEHDKRIEYIDTVYVYHYGTRFLVEVHIVMDRNMTLQVAHDISESLQINIESLIEVERAFVHCDYEFEHVPADEHKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPG4</accession>
    <name>A0A3P7PPG4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPG4"/>
    <dbReference type="STRING" id="318479.A0A3P7PPG4"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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        <ligand>
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        <location>
            <position position="230"/>
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            <name>ATP</name>
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        <location>
            <position position="403"/>
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            <name>ATP</name>
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        <location>
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        <ligand>
            <name>ATP</name>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <sequence length="482" mass="52826" checksum="E6EB70B90C95EE92" modified="2019-02-13" version="1">MHSSHLFVCFGVSTARDSSIRGPHRTCTSRILLSRRISFMRYRMVEMLRKLQLRRISRFIEMTLSKLSIDKLNLRDKRVLIRVDFNVPLKEGKITNNQRIAAAIPTIKYALDNGAKSVVLMSHLGRPDGRKQPQFTMEPVVAELKALLNRDVIFLHDCVGPEVEKVTASPTPGSVILLENLRFYLEEEGKGVDEKGEKVKADAGNIEKFRSSLTKHGDVYINDAFGTAHRAHSSMVGIHLNQRATGFLMKKELDYFAKALENPIRPFLAILGGAKVADKIQLIRNLLDKVDEMIIGGGMAYTFLKIINGINIGKSLFDEEGAKIVGNLMEKAKSKGVIIHLPVDFIIADKFAEDASFKTSNLSSGIPDEYMGLDIGPETTKQFADVVLGAKTIVWNGPAGVFEWENFAHGTKGIMDAAVQATAKGAVTIIGGGDTATCCKKWKTEDKVSHVSTGGGASLELLEGYQVLFGKVLPGVDALSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QGL4</accession>
    <name>A0A3P7QGL4_DRAME</name>
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        <recommendedName>
            <fullName evidence="14">Transmembrane cell adhesion receptor mua-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="9"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000047">
        <property type="entry name" value="von Willebrand factor A domain containing 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="30"/>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="EGF-like_CS"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Mua-3/Mup-4_EGF"/>
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        <property type="entry name" value="NELL2-like_EGF"/>
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        <property type="entry name" value="Nephronectin_domain"/>
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        <property type="entry name" value="VWFA"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="2809"/>
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    </feature>
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    <feature type="domain" description="EGF-like" evidence="10">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3085" mass="342044" checksum="8A181F198DD4EABF" modified="2019-02-13" version="1">MHDCDPVAECFSEQPGYFQCRCPKGFVDLSKDSRFPGRKCKKIVNECALGTHDCDGNADCIDTPESFSCKCKSGWSDISANPKLSPGRTCKRANLCASANCAVEAECHETQYGPVCECNSGYIDISRQHGLSPGRVCRKVINECATGKHDCSPSASCIDTADSFTCRCRDGYRDESSDSINRPGRTCVKAPAPDPPECDVNDPLSCDAHKKEVCLFINGTYKCQCAAGRDRLPDGRCLVINECKDSRLNDCSLDADCVDQAEGYICRCRNGFADISPPGKTGRICHRRINECSNPTKYKVDCDQNAICVDTEDGFTCRCRPGYADISSSFSRLPGRRCIEAINECLDAKLNDCSENAICEDAKEGYICTCRTGYVDASLNITHYPGRVCHKPREEAQKDIKESQSQLHLCDPKNPKCGQNEICTDRKVRGQFICECNPNAFRFTDGTCRLYSACTSDNKCDKNALCLNAFDTYKCQCRPGFIDMSPDPENKPGRLCKELVNECATGAHDCSSYAICEDATDGFMCYCKEGFVDTSSQFHLAPGRRCTSNECAESSLNTCDENADCIDTADSYACQCFAGFVDVSSSANLPPGRVCTLQTTCPKQKTDLMFLIDGSGSIGSYVFKNEVLRFIQEFIELFDIGLDNTRVGLIQYSDQIRHEFDLNQYADKASVHQAISQVQYLTGLTRTGAAIQHMVMEGFSQRRGARIKSDNVTRVAIVITDGRSQDNVTEPAMAARNLSVNMFAIGVTDHVLASELESISGSPARWFYVDRFKDLDTRLRSLIQKAACPSLGPKTQLPSGCNPVVQTGCNRALNEICVKNVNNCQCPDGFHRHPISRVCGGDQCNPQLPTSCPDPEICTITPFSNYRCVCPKGFLRDHRSGICLSIEEQHQPTVLPSLDADCKNGGIKCSTNEYCVQDCQCILDYERNRRTGECSAPGSCDPTVSNPCDIRKREKCLLHVSGRYHACQCEQSEKRHPVTGICLQDECSLGMHDCDKTARCIDTDDGYLCACQAGYLDQSSDQVNKPGRKCTAERNECADGTHKCSPNAICTDTVEGYVCRCKPGYVDFSPNPHSFGGVVCKEIMNECLNQALNTCHKDAICIDTVDSYKCICKNGYIDLDELRNPGRQCKKEQNNRCSAGNNDCDRNARCIQRGKNDYECACLAGYRDKSPNPSKPGRVCIPLIPECDNPTLNDCDSPDRAICTDTDEGYICRCRQGFLDISPNIAEKPGRLLEDECAKGTDDCARDGGICEDTPDSFTCRCAINYLDVSFDRQKRPGRKCKRLVDECRTGQNDCSPEAICTDTEDSYICACPPGHIDVSPDTIHLPGRRCLLRINECKENKNDCSPNADCIDTAESYSCKCRDDFVDESPDRNRPGRICKPALVDECRLGKHDCHKNAICQDLSQGYSCHCKSEYIDESPNRVSLPGRVCVARPTPPPEECRVDSSSSCKVELNEVCRLINGVAKCACPINYKRDPSTKSCTVINECNFPQLIDCHPSAECIDQPNSYTCRCLKGFKDVSPPNKPGRICQAYINECQFPHLNDCHQNAECIDKEDGYECKCYQGFKDGSPDRPGRLCKQMINECAKSSLNSCDKNAKCIDLDEGYRCECKENFLDVSPSPTFRGRACKRIINECADSKLNDCDKMAKCVDTTDSYLCQCPANSRDISPNPAFSGRLFLFITLVENECLNGKHDCDPNAICRDNEQSFTCECAQGFADRSPNQLNRPGRVCIQLVDECATGRHTCSAQAECRDLEEGYTCECKDGYVDRSPNLMTQPGRVCGTPEVCPSNHECSSAATCEPLGGNAYECTCIQGYIDQSPEGKKGRICVRNNACRDSRLNNCSRNAICYDELKGYRCECTRGFIDRSPIPSLSGRVCEPPTPPKSPPRHPCQDPLLNDCHPAGTCRATGNQSYTCECLKGYADKSPDIRNKPGRLCIVNEPICLDSSQNDCHPAAICSETEKPEKYTCRCRDGYIDQSPDKINRPGRICIEQLNECLDRSLNDCDPLAICQDLPDGYTCRCPVSAEDRSPDLKRPGRKCFQQIDECRSPALNNCSRFADCIDRPEGYDCRCREGYHDDNPTHPGTVCNYIINECESTNLNDCDRHAECIDLAGGYNCRCKSPYRDESPAGQPGRICRLNECLEPTINKCDKNAVCKDLDDGYICHCKLGFYDNSPSPLEPGRICIAFQQENLIKTIPQDAPRVDGIPCGRNEVCLIARNEVCVGGLRCMCRPGEARNSAADRCQPVEKIPLSIRVLTRDSEPLLYSSEYGNSDNIPYVEITHLFSNDLGRTIGSTSYAPRYVATDVNYITHPKTVNSSWPNGLLFNFTIALTPSSSTDQCNLWDQLMQSLQRTNGAIGGGALRVAPDVDQLDPCRPPEIRGEICGQSYCNMELGEICIAGSVCGCAHGEKRGTLNDPCRAVESWSIILWVIRKDTEVLIYNETFANPVHPLNKEYVRRFESGISQCYSQTLLKNSFISAEVNEIVDPVIINATWDRGIVFNSTVHFRKGTIQITSDVYYMLVRHIIDQNNYQIGRSSLFLNPYQPDPFRACFKNNCHPKGICIDLGPNAYRCECGSGYRDLSPTDPGRRCLPNVGYNECERKEDNECSENARCIDQMHLYRCECLPSFTDASPPGRIPGSTCVLDYCSDVNFCPANTSCVNQEQQAVCQCDSGFVDIRKSEKRTQFYKSDTLCLKLRDVDECALGLTNCSGVAECSDKAFGYECNCPEGYIDGNPDEPGRVCGALLCDLCNSHGDCVHNSLTNNITCICSDGWTGEFCDIAPSNASLILPIILAILFLLLTLCCLLYFCTKCVCFKGRSLWYREPFTYRKGGWPWSTLGASTSSDSGADFSGMSAAGHEYYPEIGIPRAKLKGGSNDDRQAQSAVIASRLNNYLDEGLRIPRAHLDNFDSTSESSSEYTIREEIERRVTTDVMKTETRKTITTADVHGTTAEFHVYPPIELSAESHSSSQVTKSSDFKMMISANTSSYMDKDEQERCESVAEFSVGKTGHNHWNNLHMRGQRVSQISADRDLESLSSDSVIEDGKYDKKTLVKRSHNYEPSPDGDTQRFRTEVTTSTVSKETSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SE40</accession>
    <name>A0A3P7SE40_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000070">
        <property type="protein sequence ID" value="VDN52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SE40"/>
    <dbReference type="STRING" id="318479.A0A3P7SE40"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32196" checksum="16D813FE1B4A7A7A" modified="2019-02-13" version="1">MSILFKRFYVKWNFFLQVISVQTTRCGFIHVYIQGNLENRNGKTMVMTVHDVGTNYKAFPTLDQIGEDLVCVLDKLDVKTCIAFGEGAGANIICRFAMSSPNRIMGICLVHCTSTTAGIIEYCKDKLINMRLESGVMSQGAWDYLAMHKFGSSDKKEKQAYIEELKSCLNPKNLSKYLFSFCKRSDISSLLGSKLENMDALLVTGARASHLHTVYTTHKSMNKRKTTLLVVDNVSDVMAEAPEKLARSLILLCKGCGVMSGVAIPGMERQRTLSRFDEFFRFSISIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SHN2</accession>
    <name>A0A3P7SHN2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SHN2"/>
    <dbReference type="STRING" id="318479.A0A3P7SHN2"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="279"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="449" mass="52415" checksum="CE10C86DDFE8CBF4" modified="2019-02-13" version="1">MQLNLKDFRRLCILKGIYPHEPLHKKKVNKGSTENRVYYYVKDINFLASEPIINKFREYKIFLRKLKNAKAKREYDRVRRLYARKPRYQLDRIVKERYPTFASALRDLDDALCLCFAFATLPHTKTITTSLVNSCRRLTAEFNHYLIESQTLSKVFISIKGIYYQAEIMGERITWIVGHDRGVGHVSQVDFAVMTTFVEFYITMLSFVNFRLYQSIGLFYPPQIVFLSNKINEEEEAEKIYSLARPLAKQVKEEEPLPDMDISSEINSEFAERFNDMEKKNNLFVNCKFWLNRETPKDLLAIIIRSCGGGVSWENCPAAFFNENDASITHQVIDRPFLSNTNINRFYVQPQWVVDCFNLRRRLPLENYLPGAVLPPHLSPFVSDTSGEYIPPERIAQLKELVEGTIKGNHGNFLNINKEQNNSKSDEFRVEEGKTHKENVQKSIDEKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SUW3</accession>
    <name>A0A3P7SUW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000516">
        <property type="protein sequence ID" value="VDN54289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SUW3"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="91" mass="10674" checksum="41FFF7C656BC91D4" modified="2019-02-13" version="1">MDELENVKVYAIYRPLPEHQYIDELRRRFAIRTAKSGQSESCLMNELEMCKKPDNQLFSLDKIVRILEFESVEDLICLAVPSSLKNTHLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0J6</accession>
    <name>A0A0N4U0J6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport protein Sec61 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS4440</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0J6"/>
    <dbReference type="STRING" id="318479.A0A0N4U0J6"/>
    <dbReference type="WBParaSite" id="DME_0000008001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000008001-mRNA-1"/>
        <property type="gene ID" value="DME_0000008001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.820:FF:000001">
        <property type="entry name" value="Transport protein Sec61 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000008001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7614" checksum="0C092E13127A0E06" modified="2015-12-09" version="1">MEYIQAVVDPSKQFAKDSIRLVKRCTKPDRKEYQKIAMATAVGFAVMGFIGFFVKLIHIPINNIIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0K0</accession>
    <name>A0A0N4U0K0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4444</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0K0"/>
    <dbReference type="WBParaSite" id="DME_0000008401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000008401-mRNA-1"/>
        <property type="gene ID" value="DME_0000008401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000008401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7664" checksum="A0A629E2AE4F24C5" modified="2015-12-09" version="1">MIGHLLAAVIASDLPSIASPILNPADFPRFLFTIGEKKTPSLSCYSEDDDDDDKWLVAVPTKWMSIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N6</accession>
    <name>A0A0N4U0N6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4482</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N6"/>
    <dbReference type="STRING" id="318479.A0A0N4U0N6"/>
    <dbReference type="WBParaSite" id="DME_0000012201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000012201-mRNA-1"/>
        <property type="gene ID" value="DME_0000012201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000012201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53747" checksum="95ADE803DCC16F43" modified="2015-12-09" version="1">MVYLHYFWTSDLVKRKKKEISRELCKKAGILDRRSISRSSQTVATTTDSISVVKSRCFEKGKSGQTSLSTSKSFYDRRAFFSKRDHKALSNASNHQFGNNESSVISVAGKSFLRHIICGEVESDDVEKDFQKKTNDRSCRIDTLAQCDVFRPLEHRRITSSQSAFTISKSFENQSKNSIYFDRSDGLSSSKFKESHSAPFLRTFKPLKSTIAESIQQNVSKLNGLSLNLNAGLTKPALKPKPLALRRERSDLTAGCVRRIANNSDQNGGTLMRKALIPPQVCLDEKALKNCLEELKRKRFPFSTKQQIDFKLSNKCCEQQSPSKATAVPNEKGKNFSPVFRPNNPSFTRSDQHRLSVPNLADLTHNLNGNTANSGIAMTAKALTSKLGRNPGTGELQTINEGLITPVVRRKQYLNDITTATAIINAPANEIYNMKPSPPYRKSNKESAMNFNINVDSKNDTAAVVEHEFTKKYVFLKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Q2</accession>
    <name>A0A0N4U0Q2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4499</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Q2"/>
    <dbReference type="WBParaSite" id="DME_0000013901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000013901-mRNA-1"/>
        <property type="gene ID" value="DME_0000013901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10613888at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000013901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18844" checksum="CA8C9F356078A571" modified="2015-12-09" version="1">MAPRYENSPTSSWIALSCFFTDSWPMLAFASAACLFIGLVFFLVGLVTLLKGTDPAVVRSWIFFCTGIFLLVMGLLMILLCRIRNPRFRSASRHRRHATTRPQNRRDPLPVWTIDAIDPTFRPPPPYSEVIQCSSNVPHRSTSDSMILSRPPPYSAASIRNSRITDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2F1</accession>
    <name>A0A0N4U2F1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5212</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2F1"/>
    <dbReference type="WBParaSite" id="DME_0000085201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000085201-mRNA-1"/>
        <property type="gene ID" value="DME_0000085201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000085201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9562" checksum="55533733A0E6A7A8" modified="2015-12-09" version="1">MEMTCEGCSNAVRKVLSKLGSKTFPGSSVRCHSFLLSPYITVTTIQNSLISPGLNCSFSLLMPTITGLATNEICVNSCGGEGAATSERDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2J2</accession>
    <name>A0A0N4U2J2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5259</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2J2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2J2"/>
    <dbReference type="WBParaSite" id="DME_0000089901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000089901-mRNA-1"/>
        <property type="gene ID" value="DME_0000089901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000089901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="534" mass="63173" checksum="15A745DE8425DC2E" modified="2015-12-09" version="1">MRPEEDVYDHTVTYKFSLFGNLVSRISRIKKMEDKRAMEKYNQKLKMYYRCMNRRDAWYANRPTAVNLNENTSSLSPEEENEVEEVWKPSESFLGKKIRKIIDKVKDSIMQNFDFYEKDERIRWDYTWEWANFSSGSGGNWQDLIKSHNSDSLSITEKALQLLRGYLTKKHRYKFGDHFELSISPMDKDYMGWYRCIKRTNDTRHITNIFYVDVFSIIATKVVYNLLISEFNDNDDSVIEKAMAYQSTKYNLESYAKATHWTDCNRCGEGETRRSVSCFIKRINENMMNSNNGTSYLQLFSDIPCRSSLVPLEVRNKFWSIEDIEESKRCTLVCTNKSEEKTRIIEGMNEMGRKTIIDVLPPGEYQINERLPPLRKKVVRKTIVSLSKNYKDNRIFINVKHELVIRYLTMDDDKSFYSCHTPDSDVVRSFSLIVNRNQQWQEQVEYIKITIRFGAFVLIMTMVFTIVLKRTAPKKEEGIEGITAIRGFNDRMTKVRSVAKWWPNVNRMAPLHEMQNETFQQMNIPNTFALNDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2S0</accession>
    <name>A0A0N4U2S0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5355</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2S0"/>
    <dbReference type="WBParaSite" id="DME_0000099501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000099501-mRNA-1"/>
        <property type="gene ID" value="DME_0000099501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000099501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21541" checksum="17FA92A5715D86E8" modified="2015-12-09" version="1">MVTVTDESGQSVERSRPLIPTSRCEDNEPELCGSLFKIPPEVAADNLDDYFLNRKNPLHSITCELLAIQRCLCINIQQLTKCSEFIVYYLLTARIPHVDSEEKCQAIFNAQLCNYSFMAKEALARCPYTCGLCDKDGAGGNCVDLALDCAILMNVMGCDYSHLRTNCKKTCEIDTCITRTTTNTVGGTITSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3D7</accession>
    <name>A0A0N4U3D7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5597</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3D7"/>
    <dbReference type="STRING" id="318479.A0A0N4U3D7"/>
    <dbReference type="WBParaSite" id="DME_0000123701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000123701-mRNA-1"/>
        <property type="gene ID" value="DME_0000123701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000123701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54348" checksum="BB413490DFF7C0F2" modified="2016-06-08" version="2">MEQNDAKCNLFINLGSETVSDSSASEILNDAVKNIDDCRTPLAELPIKKDFSSPEVTSKAERRDLGNSAANIAAMQKLDETPAVPPRHKKRRVTELRCPEVRWFYRKKGETKWNSFRGVDSLKLEIRWRQRNNIEIDKATQANMAFMQVANSLVVHDGLYCVSDDITYIYSFYWKDDEMEIRRGTWFLAESMQPIDQDMAEPIEKHHLSIFRSQTIPETAVFSDKESSKKPILTELKLKDQYEVRWNSVIDITLYNNSKTSRFLRYITWGKGTSLKRGYEEADWEDGTRVISHLILVVHGIGQKGYENLIAKNTDLVREAAYSIMEKNYAEEKSRPMILPVEWRASLVLDEGLTDFVTLPKMSSMRHALNSTVMDILYYQSPLYRNEIMGGLTNSLNTVYTKFKQNHPNFDGPISLFAHSLGSVMCYDLMTNWSPLVIYDKYVATIIENYISGDNRENVDTFHAFQNARQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3P7</accession>
    <name>A0A0N4U3P7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5717</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3P7"/>
    <dbReference type="STRING" id="318479.A0A0N4U3P7"/>
    <dbReference type="WBParaSite" id="DME_0000135701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000135701-mRNA-1"/>
        <property type="gene ID" value="DME_0000135701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184109at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF2">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000135701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20311" checksum="2FB329C8E5FB7DA1" modified="2015-12-09" version="1">MAAEIHIIGSVDCATGFPSNRLFCKWNLEIGYDFIKLNSIIEGRSEGQTQVDLSEVDDIACFSHPIDVHLATKTVQGWPSIKLEVWHFDEFGRQQIYGYGFVYVPVASGEHKLDCYIWRPKGDTREEMMLYFLGGGMQLATASLSSHFTQTVKLRTVAMGTVKLLLSVITRHFDRFGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3Z6</accession>
    <name>A0A0N4U3Z6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5832</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3Z6"/>
    <dbReference type="STRING" id="318479.A0A0N4U3Z6"/>
    <dbReference type="WBParaSite" id="DME_0000147201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000147201-mRNA-1"/>
        <property type="gene ID" value="DME_0000147201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="18"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000147201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62753" checksum="1B2337EB417312A1" modified="2015-12-09" version="1">MDENGESPPWERFSRWIHCICVVTFDLELGQAIEVVYPGDAQLSAAEKMNICYLAFPDSNSCCTRDTKFHFRIRRSSFQLNEVQTNYSENVPPAAQIDSIHFFGFVHFRQQKDASLPRGYYQKSLVIISLLPLFNLFSYIIDAIANNFFESGEPAIEAACHDIDHWRAPVPGELLYLPLLGRVIQCRIPCKNDLPFMQKQKIDEVLYCEFSNLQCMLNYIQLLWELVLLGEPIIVMAANPLTCSSTVQALVSLIWPLRYFNDYRPFFTIHDSEFREYASKKQNPPKVILGVTNPFFSKILQHWPHVIRVGNGSHQSVSTEGIARKLRDGRIADSKPGLYTQYKTFLNSDKALVKNILKCDKFGGMQNKILRRHMLELTHIFMMPLERYISTLMPLRKQISPFKAVPQARPFIVDEFLSTLDEASTSVTCGIKGDWNGLYRKFLSSKNFEGWLRYRRKDVDRQLKAAHLEVLSNADFSPDALKGRHQVEIVDLILKISDRLRDLKEPALEARNRLQFQLTTILQSVDDELKSVLLSNGSLRDCIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4S1</accession>
    <name>A0A0N4U4S1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Robl_LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6157</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LAMTOR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4S1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4S1"/>
    <dbReference type="WBParaSite" id="DME_0000179701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000179701-mRNA-1"/>
        <property type="gene ID" value="DME_0000179701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343907at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378">
        <property type="entry name" value="REGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000179701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16737" checksum="515176262072136F" modified="2015-12-09" version="1">MSDSRSAQLIQLHRDLLFASISVAGNMEIKKSLLNIVMKTDGVRQIFITDKDGVLVVYSTRLQGDNSSFRAHLINCYQLALEHTAKLNIGEQRTAIFCFENYQMVILNFNGLMAFIIADTDCPAGKLRDLRTPLNPIMEEISGAFSASHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6A7</accession>
    <name>A0A0N4U6A7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6804</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6A7"/>
    <dbReference type="STRING" id="318479.A0A0N4U6A7"/>
    <dbReference type="WBParaSite" id="DME_0000244401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000244401-mRNA-1"/>
        <property type="gene ID" value="DME_0000244401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868330at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000244401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="33839" checksum="B2A6918F8064B02B" modified="2015-12-09" version="1">MRCYKDEYSIDISQKFHEAESLRRIAFFGIILSIVAALTTVIAIPALYGYMQRVQSVLQLEADYCKSTTGSMWQQFAKTQAHKGVYTRLKPQSGMEAFLIGTAQLDRSKRANSINAAYHAQSEGVDSSTKILHDPDTCLCQIGPPGPIGPPGIDGDDGIDGMPGEDGKDGKDAHPYKVQKDFCFECPPGPPGLPGIPGPKGPNGKPGLHGKRGLPGKPGASGPVGPPGLPGLPGQAGPKGDTGQPGIVIEIEGTPGPPGPPGPPGPKGLPGKSGAQGKPGLPGPPGPPGEPGRPGPHGKDGLPGERGPAGERGAQGSCDHCPVPRLAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6F0</accession>
    <name>A0A0N4U6F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Multidrug resistance-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6852</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6F0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6F0"/>
    <dbReference type="WBParaSite" id="DME_0000249201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249201-mRNA-1"/>
        <property type="gene ID" value="DME_0000249201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000015">
        <property type="entry name" value="multidrug resistance-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000162">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="127"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="440"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="706"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1280"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1351" mass="151761" checksum="464D3461A22DAF92" modified="2016-06-08" version="2">EDSTDKFKIRYARGQAESKTFARYASSLRNIIPVRSFKRRDGNYSTKVDESGLFSFITYSWIFSYLWAAFKGRVNENQTWNCSMYDSSTINSTRIEYLWKLELEQNPTKPSLFKVVWIFIKTRVIMASIVFFFCLIFGFIGPTCFVRGLISYAEQPPMMGEMPNFSLGLILVLSLLLVELARVLSYGATWAISYRTGIRLRGALLTFLYKKLINAKSLGKRTSSEIVNIYANDGQRLFDAVTFAPLVAIGPLVIIGGIIHLLFVIGPWSLLGILIFLVFDAFQFVLGKTMTRFRASAIKKTEKRINLMGEIIRCIRLIKMNAWEESFKNTIEEMRRNEKIDLRTAGYAQSLAIASGPVVPVVAAVFTFMGVILSDGDLLASEAFSAITVFFVMLFGIRMIPYGSRYCAEAYVALQRIKEIILMPEYEIAFPAPGDPSLAIDFHNATFTWRENACKLELIMILYILYLIPFYVQKELIGVCGPVGSGKTALLNSLLGHVAYVAQTPWIQNLSVQANILFGLPMNTSRYYRVITACELSKDLETMKAGDQTEVGERGVTLSGGQKARIALARALFANRQIYLLDNILASLDTRVGDRVFRTCIKEMLGNKTVLMVSNDPKRLSNCDRVVFMDSKRIVGFETHENLLNECEAYALFCNQISSAGNFTNHGKYWRKLCIHNEENFGFTVVRWPIYKKYIRAAGGYLIWTILLLAFVINVASSIFSTAWLSHWLKNGHTSRLVNANSEIVFETTSLAESDSLSYFVSIYALSLLFLFASGFLKALIFVKVSLNAASHLHSQMVNSIIKATVQFFDTTPSGRILNRFSKDMDEIDVKLPFTTEVFLQNAFICLGYLIMIAWVFPVFLIACIPLSIIFGLFVFCFRAGITCLKRSENISRSPLFDHITSSMDGLQTIHALGQTEHFIETLKTNLDFNSSAIFMYQSAVRWLAVWLDLLVVFVTFVVSLLIVLLTGSVEPADAGMALAFAIQMSGIFQFAVRAQAELEGKMTSVERVSYYCDHVESEGEWEFVIVCLSLIFSEPNYFCRLRYRLNLPLALDGITLRIEPKEKIGIIGRTGSGKSSLCNVLYRMYPLTWGSILIDGINIAHIGLHRLRRGMAIIPQDPALFAGTLRFNLDPTNEFNDDQLWNALEKTCLKDMVSSLEHKLDFNITEGGRNLSVGEKQLICMARAILRRVRIVILDEATANLDSVTDHLVQKCLHEAFSECTVLLIAHRLENVLGMEKILFMEQGKCVEFEKIAKLLSDKDSRFRALLGQKKALEFLSKQGESNKTEDDGSGSNTSSPVHLYPALNENGNSGKGSPETSEFEKISGCKATTNTSGDISDLEIIGDDTIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6F8</accession>
    <name>A0A0N4U6F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6861</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6F8"/>
    <dbReference type="STRING" id="318479.A0A0N4U6F8"/>
    <dbReference type="WBParaSite" id="DME_0000250101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000250101-mRNA-1"/>
        <property type="gene ID" value="DME_0000250101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF6">
        <property type="entry name" value="FOG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000250101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37907" checksum="0CA9BEAD55FD7DB3" modified="2016-06-08" version="2">MAVVLRINCLDAIKKFFDQFGTATVDWPYRDRNSTNIPNGYVFVVFANNLSVQSLIENCTLHQGKLSIILKNKNENIKMVEIRPWLLSDQEYRISRTAINRHYSIFVGGVPRTTTAKELAVVIQQAIGYVLLVTLEVDSDTQYPKGAARVVLANREAYVTAIAMRFIKMIKIEQEKEMEIKPFLQDFAQCEECQLLFTRHFCAEVCCLVYLCESCWLRIHNSRGLIGHKPMLKGRHKMKTQNVEQMPLRFLNANSLQYQQSHKQQRKQCQQQLQQQKQRQQPLQGQNSYGRNRVYYSNKEYQANTNQNLLSQNREKAFFTLLNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Z1</accession>
    <name>A0A0N4U6Z1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7086</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 9"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Z1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Z1"/>
    <dbReference type="WBParaSite" id="DME_0000272601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000272601-mRNA-1"/>
        <property type="gene ID" value="DME_0000272601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000272601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29843" checksum="88FBE3D1614376C3" modified="2015-12-09" version="1">MPSKEDILTPEEEIRLKRCILSAKRDHLPPICTHNMVDDAGDQVLNAFRRTNLINKPDDRVKVIFHPEFLSSVSPLMNLDYEDFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSITTNLSGFGCFINEHVTDPGSYGIFVVDRRFKSANESINDLTNQLYNFALLSRRQRIIMRNRTERLSEILDWKTLGAFYREARRAALQKTHPDLDEVINKTLQKLPRPISAASTPVTSRQTTPHPSDNEVSDTEEQEEFEARAWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7G4</accession>
    <name>A0A0N4U7G4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS154</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7G4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7G4"/>
    <dbReference type="WBParaSite" id="DME_0000292501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000292501-mRNA-1"/>
        <property type="gene ID" value="DME_0000292501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23816">
        <property type="entry name" value="RWD_RWDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000292501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26975" checksum="4E899BDCECB98009" modified="2015-12-09" version="1">MDYNEIQLEELEALQAIYPNELKIINREYPNINVSFYFRPNENEETSDIFDILLVLKFPKNYPNDIPLIELENHGKNNFVEEEKLKNIINNLCIVANENIGMPMAFNIISSLQDEIGYLIDDIKVKMRQADEKIKEEEEALERKKFEGTKVTVETFMKWKENFDREMNTLKERQLKEKMSLGGKLTGRQQFLNNSALNNSDIELINNVEIDESLFEEELDDLNIEGSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7L7</accession>
    <name>A0A0N4U7L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7144</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7L7"/>
    <dbReference type="WBParaSite" id="DME_0000298501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000298501-mRNA-1"/>
        <property type="gene ID" value="DME_0000298501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867782at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000298501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9533" checksum="E925D9CDFFAA1030" modified="2015-12-09" version="1">MVGSSPYWIGLHKFGEQWIWEDGSPFLFANWRSNQPDNCCGADVTCTIVNYRANNGQWDDAGCVNVWKNPTSFVCKKSFYNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7W0</accession>
    <name>A0A0N4U7W0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7252</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7W0"/>
    <dbReference type="STRING" id="318479.A0A0N4U7W0"/>
    <dbReference type="WBParaSite" id="DME_0000309301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000309301-mRNA-1"/>
        <property type="gene ID" value="DME_0000309301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF39">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000309301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16276" checksum="19128E0C87BE90DE" modified="2015-12-09" version="1">MSKYIYSTPPQDELRIVSPLEGAGSPQIPSTNMPQTVIYSLFIDPPVANFQTTGGTSVHKLINHTGIRLAFKIKSSNNKDYRMNQVYGFLEPEMAFPLIISRIGGQPRIDKLVVQYKKAVPNLKDAEENFKQGPPIGEITMQLIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Z5</accession>
    <name>A0A0N4U7Z5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe_hyd_lg_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7296</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Z5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Z5"/>
    <dbReference type="WBParaSite" id="DME_0000313701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000313701-mRNA-1"/>
        <property type="gene ID" value="DME_0000313701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="3">
        <location>
            <begin position="100"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000313701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="51971" checksum="ADBA31536FFFE639" modified="2015-12-09" version="1">MEEGGFSSVVRISNVSDFIAPSQACILPLRKNEKEDSATISVGIRKRSNGINTSNNKKITVSLNDCLACSGCITSAETVLVQEQSTAKLIDGLSRCKLGVVTISPQAICSIAVKRGFSVAETSIKLAKAFKNLGATYILDSSFGRYLSLSLSFEEFKNQRMKGTIFCSACPGFVCYAEKTYGNLLIPHLSRVRSPQAMMGSIVKDYLAKLTTTNVTDIFHATVMPCFDKKLEASRPEFSGSGRQVDCVISTAEADDILGNCSEEIFANQVAPSSGGWLTALERGIIIGQFENISNDLFANTSGGYADYIIARFLKEYQGPLEVRKSSKQAFFSICLFHLAKNLEIFEIAKGELVLLTVAKCYGFRNIQNIVQKIKRQKCPFDYIEIMACPSGCANGGGQIRAETTEERENILTRVEEKYRQLIPSAEMECEIERVKNEWASFNDSFEKLFYSSYQVVDKSIMESFNLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U838</accession>
    <name>A0A0N4U838_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS7343</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U838"/>
    <dbReference type="STRING" id="318479.A0A0N4U838"/>
    <dbReference type="WBParaSite" id="DME_0000318401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000318401-mRNA-1"/>
        <property type="gene ID" value="DME_0000318401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="225"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN57370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000318401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50971" checksum="F4DE3A9977D4873B" modified="2015-12-09" version="1">MLITMGADLSCRDTTYANTALHWAVIQGNHSAINILIKFNADLTIRNRDNETPRDIAIRRGDAISLRMLERAERKAGILPSTFLQSIKENNSFISKSMLLLPLIIIITIGLILNSKFSYIFKTFCLLLVIFSTWLTYRVLPSSESCSLLPLGLAIASKVLCIFTWLFYLHPFAGWHMQIIFFFLSLSVPILFLRIVFADPGVISVTHEERCKMIRDIWEKQQVAASFCATCLIRKPLRSKHCSICDRCVRRFDHHCPWIANCVGEKNHLFFLLYLGVVILSSLLMIFDLMNSCGEISQMTILYCNTWVTYIAFMSLYHFIWTASLFAVQIYQILYEMTTNERLNSFRYRYLHKSVDNLSTRSPFSYYCDRELRKICIHRLHKKNFISFYWKEKQEIQNKSRKRGKLQNKWLCSGEKRKNAINFLDILDCVYNIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8I9</accession>
    <name>A0A0N4U8I9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="2">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS230</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8I9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8I9"/>
    <dbReference type="WBParaSite" id="DME_0000336401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000336401-mRNA-1"/>
        <property type="gene ID" value="DME_0000336401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000336401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41638" checksum="35DE21C029E30A60" modified="2015-12-09" version="1">MKTFTIVSLEDLHLRKPFKSNYVIDQHTLDRQTLPSALSDCYNLCDPPPNLDALNPYRDDKKSALRYYTDPSYFFDLWRQEMLKDVGDGRRQRAIRSQTENKSPSRKKRNKQSTSNEHLIKTSSRYVIASQQRCLDIMNFPAEYQAPNIVSNDQMYIPVGMSVPVSMNAHSEMNITSRNGEVRTCSTIVTSTNSHLVTQDDATAENSPNAVSSQMAGLNLQDVPMLDDDDDLPPPPPPLMHTSLVCQMPNPPLMQFVAPSENRVAVPPSPPLPPPAPPAPVITVVHSFANTNGEEVKTKTEKPIQAPDSHLNLLAEIQSGIKLKQVQRKEQAAEEKAAAEANDVAAILRRRMEHVLGNSDTETESPSDDDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8R2</accession>
    <name>A0A0N4U8R2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase/reductase SDR family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS314</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8R2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8R2"/>
    <dbReference type="WBParaSite" id="DME_0000344801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000344801-mRNA-1"/>
        <property type="gene ID" value="DME_0000344801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000344801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35123" checksum="F245E6A1CFBDCB3E" modified="2015-12-09" version="1">MSLAGKIAIVTGASRGIGRGIALQLGEAGATVYITGRPHEVSISQTGRDDLPSLQKTADEITERGGKGIAKYVDHSDMNQVKDFFSQVQSETDGTIDILVNNAYSAVPILGKESGKPFWETDPSIWDEVNNVGLRNHYFCSVYAARLMVKHRAGLIVNISSFGGLQYFFNVSYGVGKCALDRMAADMACELRKYNVSVVSLWPGVVRTELFSDIVNSADIELTGYKLKLKTMLEDGETVEFSGKAVVALANDRNILKKTGSTLVAADIGLDYRFCDVDGRAPPSIRSIKNLLNLGGYKKIAEYVPSWLRLPGWLMVAVNSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U911</accession>
    <name>A0A0N4U911_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Semaphorin-1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7557</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U911"/>
    <dbReference type="STRING" id="318479.A0A0N4U911"/>
    <dbReference type="WBParaSite" id="DME_0000355201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000355201-mRNA-1"/>
        <property type="gene ID" value="DME_0000355201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000016">
        <property type="entry name" value="Putative Semaphorin-6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="14">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000355201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="633" mass="70697" checksum="152A2EB3D3AAD406" modified="2015-12-09" version="1">MANLEVQHVLEWAPPGQTVEDCLMKGKSRLECHNYIRVMIRQINGRCLICGTHAFSPKCREYIFLNDDRLLHHRREFDGQAISPYDPRDNSTAVYVGETDEIYTGTVSDFASNDPLIYRKRLSDDDGLRTQRDDLKVLDSPNFVASFAYGDHVYFWYREWAAESSDTDRQVYARVARVCKKDRGGARPAHERWTSFVKARLNCSLPSNTPFYFNELQAITGPVPYNDGTTVVYGVFTTPESGIKMSAVCLFRMEAIKRIFDYGHFKIQKTPQSIWMPYRPRDVAMPVPRPGSCTTDSSKLSETIVTFITKNPLMHETVIAVGHKPLLVQGPDRAEFTQISVVPQVSSVRGFKHNALYLGTSDGRILKFYDPGDGKTALVETVRIFARNVPIVNLLATTNQIIVVTSDEVAAISLYHCDEQKTCSGCVHLQDAHCAWDLDSAHCVGRSDGKWTSGNFVQNVNLGRSEQCPEGAIDPDYYAIDELQSDRVSQWDYQQSSVSVQALLIGVIIAVTIASAGGFFVGYRISGWRSLHDPRHSSGSSSGSDYDSYAKARLTRHDSLLANKMEHIYGMAPTKDTVSLVLSMPQNGTTAMNSISNGGSGNITPKICPERTVFASLSHTTLPRDYKVKKVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA71</accession>
    <name>A0A0N4UA71_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS392</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA71"/>
    <dbReference type="STRING" id="318479.A0A0N4UA71"/>
    <dbReference type="WBParaSite" id="DME_0000402801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000402801-mRNA-1"/>
        <property type="gene ID" value="DME_0000402801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="13"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN50419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000402801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46743" checksum="BCFE39CEBABA700C" modified="2015-12-09" version="1">MQQKNKSVSKKKNVQVAVRIRPLNETEKSEKARISLTAYEDKRTIMVKERCANKEFGPFDKVYGMHSSQLEIYTDLVKPLVQEVLAGYNCTIFAYGQTSTGKTYTMEGIHSHEADLDWKADTTAGIIPRALQHVFSQLEKQPNDDYSVRVSYVELYNEELYDLLGRSDIEQTRLRLYEDPIRKGSIIISSLEEVAVHNRDEVYNLLRKGAEKRRTAATLMNMTSSRSHSVFTVTVVMRESATVGEELMKQGKLYLVDLAGSENIGRSGAVEMRAREAGNINQSLLTLGRVITALTSGASHVPYRESKLTRILQDSLGGKTITTIIATLSPSSTNLEESYNTLDYAARAKNIKNHPEVNQKLSRRGILKVFDEEIERLKRDLQAAREKNGIYLDKDNYEYGFFHMKLMPLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBD9</accession>
    <name>A0A0N4UBD9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8398</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBD9"/>
    <dbReference type="WBParaSite" id="DME_0000451501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000451501-mRNA-1"/>
        <property type="gene ID" value="DME_0000451501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862690at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000451501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34232" checksum="EEB84E2CB454D8E8" modified="2015-12-09" version="1">MIEADMSYPKAIDMRRTSRAQTFRTQTHNSRWPMLKEENPSLNYATPNPKRSDVDCSMEKISRSYADEERSPSNTCCCGVVHIRYGTILIAVLSLISSIINGILFCLGISRAEINFAIEFLLFVIDLFGILALFYGIIYRRAGYLKPYLFINILWNFVMLLLFFLCAIQLIKDNDLSRNIMRNLLEITGFRLNRNQISSGQANYSMSHNKKCLAISVTTTVTFLMVGGLLLAIGINFWFLYIVFLCFQWINAYNEKSREPSENNAQKDLVTKNCEPKIENSTNRLVLKDLNKNPKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBR5</accession>
    <name>A0A0N4UBR5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8549</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBR5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBR5"/>
    <dbReference type="WBParaSite" id="DME_0000466601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000466601-mRNA-1"/>
        <property type="gene ID" value="DME_0000466601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="11">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000466601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19681" checksum="7C517C16B48A3EDB" modified="2015-12-09" version="1">MIFGSWSGVVDAANANIFDVSFVYNSCGTNWNVCSPLNASGYPGYPGSAVDLAIFSSHCSGVAFVFVCLDCFCYCFFLVLTLPVSAGPMLLMDCNLFWFFGYPEVYISILPAFGIFGQSNFRDYFSAATMVIAVSTGVKIVCCCDVFGCFVQLCRNLKYLKYQLYRTFRGLICGWNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBX1</accession>
    <name>A0A0N4UBX1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8612</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBX1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBX1"/>
    <dbReference type="WBParaSite" id="DME_0000472901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472901-mRNA-1"/>
        <property type="gene ID" value="DME_0000472901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="444"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="824" mass="90260" checksum="7003415F1CDF37F7" modified="2015-12-09" version="1">MEILEISHFNICQQRRFDLLIQFQRAQLAMQHMNYFQAIHGTTNGTNVGQNEQNIQTLPQNFISQLNSLNSVDTSEDSDNQQFSPTSKENFCIKTRRALPGSGQTISQLTKDRLKNMITTKMNRSRADSNVLISHSSQSSSVTGSGVLPSSSAINSGCAWNNNLDHSTSQKQMIASINAPTSSPHFEPYPIPSTVHASHSGAALPSIYQLRKVNSEPNLKMRIRAKLLSKGSSPIQMHHSSAFTFPLRQNLSNDGDFLMDTGFGSNVSVEQQQSSPLFANAPHLIIPSPSLPNLTSSLQMDMSVLLAQAAHSPFFSMPSLQKTNLLATPPISIIDSILDPVMSSEANNRQSIKMDLRTFYSPIPLGGYPSLLKQQLRDLVLRRKSLVREEPEDEAALDVSLLPRTCDGLSLSSDSADTIILKTGLVYDSLMAKHQCVCGNNNNHVEHGGRVQSIWATLIESGLVDKCERINSRKASLDMLKMAHSPTYVTFFAVSPTACLKMEPTQLPVKSFVQLPCGGIGVDSDTYFNDASTQIAARLAAGCLIELVSQVAEGKVRNGFACIRPPGHHSEYDQAMGFCFFNNVSIAAKYLQHRFQDSYSRIAIIDWDVHHGNGTQLFFESDPSVLYISLHRHDNGNFFPGTGAVTEVGTGAGKGFTVNIPFCGEIMGDCDYLAAWRVVVIPILEQYNPNFILVSAGFDAALGHSQALGGYQLSPQIFGHFTRQLMNFADGRIVLALEGGYDLPSMCECALECVKSLCDNSSGTNGKLSEEALTAIPKQNAQDAIQKVIAIHKRFWPCLASSQGIGMSELHWQTMAQRFATLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCE0</accession>
    <name>A0A0N4UCE0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS552</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCE0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCE0"/>
    <dbReference type="WBParaSite" id="DME_0000493101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000493101-mRNA-1"/>
        <property type="gene ID" value="DME_0000493101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000493101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31785" checksum="258B84CA7ACB85D0" modified="2015-12-09" version="1">MLFCRPSDILSNVVGRVMQSACIFSSYRMVMPSPFGDSVIEEKEMIRLQRGMYQMQNQSLFLYAPISKAWFVHCQWKYKCHTPHEKCRTNNAWSWSIQDKTRVIIYYKTYFLLSGSVIRIYLSVVNEEFISLSLRDILHFSKIGKLFILKLFYQNPSSLITALILIYYSRWIERRFGSKKFLNFLVINFFLSIISELIVFCFLSYINYDSSQIFFPCGPSALLISLYINFIREFPIVPFVSIFGISLSIHNLPFFAFLQKFWGVQELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCZ3</accession>
    <name>A0A0N4UCZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8961</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCZ3"/>
    <dbReference type="WBParaSite" id="DME_0000516201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000516201-mRNA-1"/>
        <property type="gene ID" value="DME_0000516201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000516201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26357" checksum="661DF6628EE04FC9" modified="2016-06-08" version="2">MPKTVFWIVRHAEREDNINSNWRHNSTLKSDNSPLSRRGQGQANEIGRRFANVKLDHVIASPFDRCLETATRIIGERNIPLKVEPGLVEALYLCNDPPGYESLETISKKYPLVDITYKSVMPWKLPSEGYGDDACTKRVRETLNGLIEKFPGSNMLLVSHGAPIGAIHEIFSGKWKYVGQATVSKFVQTKDGKFLKELSSDDSHLSDKSNLRPWCVSFCIYFSNISINFHAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD38</accession>
    <name>A0A0N4UD38_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9017</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD38"/>
    <dbReference type="STRING" id="318479.A0A0N4UD38"/>
    <dbReference type="WBParaSite" id="DME_0000521801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000521801-mRNA-1"/>
        <property type="gene ID" value="DME_0000521801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000521801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26629" checksum="6E436ABB607F5E86" modified="2015-12-09" version="1">MRENSINCDIKRILHDANAVCFDVDSTICQDEAIDEFAKFLGYSENEIKKLTDMAMNGEMGTFQQSLTSRMYLLRPTKSQFNAFLSNRKILLSPKIEEFVFALQQRQIHVYLVTGSFRSFVLPVASILKIPKENIFANDIKFDCNGDYIGIDTNQLTSDSGSMNVGKAAVCGLLKQKMGYRNLVMIGDGITDLEASPPADVFIGFGGNKVREKVRKNAKWYVYDFNSLLEALLSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD41</accession>
    <name>A0A0N4UD41_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9021</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD41"/>
    <dbReference type="STRING" id="318479.A0A0N4UD41"/>
    <dbReference type="WBParaSite" id="DME_0000522201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000522201-mRNA-1"/>
        <property type="gene ID" value="DME_0000522201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000522201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24368" checksum="32BDDF9B02EF6270" modified="2015-12-09" version="1">MLKISFSEYSKFPKSLNDTKQLGSVLLKYKEKHYYDVLLRISTIYILLQSFAIPGSVFFTMLSGYLFNVPIALSLVCTCSACGATICYCISNCLGRHLILKWFPGYVKKYQDYIASCGDNLFFYLVFLRITPFLPNWFINVASPIVGVPLRSFFIATLIGVAPPSIVIISAGTALQALTSVTAAWSWKSVVMVILCALFSLAPIGYQKFKSMEKQKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD93</accession>
    <name>A0A0N4UD93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9083</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD93"/>
    <dbReference type="STRING" id="318479.A0A0N4UD93"/>
    <dbReference type="WBParaSite" id="DME_0000528401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000528401-mRNA-1"/>
        <property type="gene ID" value="DME_0000528401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000528401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11334" checksum="457B9540736101A8" modified="2015-12-09" version="1">MFPNQARFRPELGCADQIFTFKKDVKEEEHCFKYLQPTVTCFIDFAASFDSIDRKALWKVMECDGVPEMIIRLIKAFYEHTSAQVCKYGKLTETPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDC8</accession>
    <name>A0A0N4UDC8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9127</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDC8"/>
    <dbReference type="WBParaSite" id="DME_0000532801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000532801-mRNA-1"/>
        <property type="gene ID" value="DME_0000532801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000532801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22920" checksum="C8C7C4D6BF8F7805" modified="2015-12-09" version="1">MIRPNIIRFGYASDQRRTIPMTTFPTRTIHEKSPQKHDSKKMKKVTTKLDETVSSVPLTQSFQESRQRTIPIQYEAKRKEEVVVAVHGSKEESEIENLTIPKSEKKSGVDFNVAKPENNIEARQIPISDYIKPLDQSPFEPRKDSAYVEQKRMDMLDQKQVRFDVDDQAKDSAVVSTADEMKSINTEYQSVKTDSIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDE0</accession>
    <name>A0A0N4UDE0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GP-PDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9144</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDE0"/>
    <dbReference type="STRING" id="318479.A0A0N4UDE0"/>
    <dbReference type="WBParaSite" id="DME_0000534501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000534501-mRNA-1"/>
        <property type="gene ID" value="DME_0000534501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="131"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000534501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61162" checksum="89B1582BD26ADC92" modified="2015-12-09" version="1">MHPATIHFQILSSDEPLFHEQSLFGEEFKVGRDYFVFRTRSVAVAYLGFRLELFLNDCDNLNSLKRFAVAYAMPNAFPGDYGVASVNMMSKHDRPIGLLRVDYLFMNPLLKDVQLSMAVRTFSRHWKKRQALEVGHRGMGNSYTKMAAGRENTISSLNSAASKGADYVEFDVQLSKDKIAVIFHDFHVLVTVAKRDLPVFQANDSANDLSSNFHEMAVKDLKLKQLQLLRVSFHLFCLIIFIIYIEKFCSNSNSSDHFHLFPFQLEHRNVSLILCRNDSLPKGSLRLTAEADEAAENHPFPTLVEALQRVDPSVGFNIEIKYPMMQRNGEHECENYFKHNEYIDIILSDVFKYAGDRRILFSSFDPDICALINAKQQQYPVLFLCLGLTTRYEPFVDLRASSSNSAVNFAASLGILGVNFNSEDLLRDPSPIERARHFGLVSFVWGDDLNCKERIDYFKKVLLVDGVIYDRIGEICGERRNVFLIEREAKTSLFKQGVSPTSLDDTPSSPTISEKSVSSYSSTVSSISPYRENGYLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDE3</accession>
    <name>A0A0N4UDE3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCHIP-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9148</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDE3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDE3"/>
    <dbReference type="WBParaSite" id="DME_0000534901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000534901-mRNA-1"/>
        <property type="gene ID" value="DME_0000534901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866597at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000534901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47838" checksum="2229B32642E54364" modified="2015-12-09" version="1">MQRLSSWLDQLPLRRRGSNRRCDIQGPQKHSLSAAPCVRYSGSTVQNYRSNDNGQKSQTLKRSDILYEATPHYQCDTFNQTNESLSRSFTSSFNSGRKIIRTNPWVHRNPSILPNTTRLHKPPNELFYASMDHCACMKNLDESTCSSGYCSQESSPESSLISPNWQPLFEIGQRPQLEDKAVECYSIDVDEALKSPGSSLNSPNMQSSLEIRQCRQIENKAIDCCSVDLDEALGLDNYKEDSDRYAPIYKYMDDDSAHIYHELESFNRLSIMLDDDRYYSSDSEFVASSSGASPSPRSPSPIYAKPYAYSPIRKGQYGNDYPNVSSSFTYIPCCKTEPQFHAPPPPKVTTFEKDELDFLAELDAQITELQIKSVVVRKMVDEARERHNARNRNAQIFMDQLAELRSMKWAMQNHFELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDP4</accession>
    <name>A0A0N4UDP4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AsmA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS569</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDP4"/>
    <dbReference type="WBParaSite" id="DME_0000546301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000546301-mRNA-1"/>
        <property type="gene ID" value="DME_0000546301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000546301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12685" checksum="8029DA1E5682FDB8" modified="2015-12-09" version="1">MSNEFGSKVFPLVNMDYLGLSQYEIEIKRLFSLDRASLINHPLGGFHVGADITANVITLNVTNHRLGRQSLKETESLKENDDPIGLKFNPKKVRFDLEVKKIFYDTKDEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF72</accession>
    <name>A0A0N4UF72_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS1008</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF72"/>
    <dbReference type="STRING" id="318479.A0A0N4UF72"/>
    <dbReference type="WBParaSite" id="DME_0000606901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000606901-mRNA-1"/>
        <property type="gene ID" value="DME_0000606901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="5" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1506"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="1454"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="14">
        <location>
            <begin position="1582"/>
            <end position="1632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN51035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000606901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1641" mass="188312" checksum="997A962C018B5DFC" modified="2015-12-09" version="1">MSNAVEVSGITGFQPSESAVGNEAEKLQAIIMNHVDSVQMREMFWNISRNVDMEEVTCNEAIKLLKTMTDEEKTQCCKSALNLLSNKDDPRYVHIERMLSAIFIAACNAGTLSLSECCELLILNTNFTLSTPLDTQKFEYMQKNLHLIDYKGLRNLLKLLVVERMQEIPPTITHSHRQMLLPVENMLLTMIDRKLNLLPCLFTITELHRVSNNSRAFLLPRVAKKFNEMFISFRPLTEMVTVIGRPWLFPLSAHVSYPSSASSWKLEIVTFRLHQRAHLPYKSELFAPQSSLLYTLIRQPRGKDAISHVMRQSTNVSPQRIQCDELLHMIILEAMSEMEKTEIRLDDPANQYQWMNVTHTVTFTLLHGNASFSRLLKMLYESLIETIYRKGRNELMWVILQYVAVYIAKVSNEDMMRIADIYSLLYSDEQTWSGADTDPLLFVRFLVPAAIWIHFYKKLGNQTDLLPKPSESLFRQIQFLQERTADSDPAIQNVADHNAVLAAVANAYSNDMPNFQKFVLSAVDIFLDGSGDDVGRLPYGVLCYPKKIPLPLPLIDSLTFHARSHLFQLCMVKITTLLSVQHNLKYPSPASIDTLVRLAATTEFEYGVKQLLSLMAKALTTITTNANMNPNSHTDRSRELLFILCEILSYRLIIYPVPAYSKVSVILQCYSAISCPQVQMNHTLYSSLEQVLLRYWLWNTPSELSVMCSVLFGKQGKFTALINSPNSFYEPQHISTVVHERTHSLHMSPEVLRYILLSLFRGLKMTGIEMPSEVLQRCNANFSWPASISRTFSGQIFGCTIDEGTDTTHLEELLHCVHQDVRHTQDFLFNQAITPEEQLIKFFTVEKRCTLFCVLYNIVYETKKVHPVFYGILGSLNAKEIIIMVNKFVDYFVYLLKKNLPEDSAFTAMVSVLNDMIFSFHLIPFDRLLISLVLHPTDDRSSEIAFLIIHSLVSTFPDLRARMAAISHYIPSNKIINTNLSYFNKLNEFYSQHPELTYRELELKLRREMQMEMGMRPMESTIISECHMPIYYSNIVERMLPVIDVLLMRAFEPVVSDQLFSSLLMGFKSAYRFHPQPTMFMYHVLYTHDKCMTLAGRARLFVSEICGQLEDKFSSILHRLLTFINPIYKNVLSDTKFAIVSPAFMNDNYQLIMPSQLCQTLVDRIIQSCFYAHQPPSFVCKDWRFAEMPPASQTLLGACIEILASPHPPNVITRALIDTVFVRPLHQPYATINTVALILTSLPSPYQSVFYEHIVSVLDSETLLQADPSICFDTLENECFLLTESQLLTNIALGHAYLQHCNTSALGALPEFVREQLAPKLITEAQLIFVLRLVVPILQRFYDAKERSKQIQDLAIDIYKMTVKVNEQVGTLQYEDSVCDLLYHMKYMYVGDFVKNEAEQAIQRLSPSMQEKLKYISHSQSNTSDFFHAWIKMPSKQADISFAQAMRSIRQCPWYWGNLTWIESELLLNHSQPGSYLIRDSASDRCIFTLSYRTEKSVHHTRLPQYGGLFCLGGLRISCIFGNFILLWVLLYLCGSRCSPNSLVKAKTLRAFVEEAIKSCEKRGICMLMHTKGDRSATENVALIRPLQRHEFLPPLKYLCRLVIRHSANPTALSSLPLPPTMLNYIQDRRYILPPFVLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFJ1</accession>
    <name>A0A0N4UFJ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1106</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFJ1"/>
    <dbReference type="WBParaSite" id="DME_0000620901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000620901-mRNA-1"/>
        <property type="gene ID" value="DME_0000620901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="85"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000620901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45248" checksum="CFCE48318D8CEB03" modified="2015-12-09" version="1">MSAEMDGDDNLDANMDEYYENDQHNDLRINAQISLNSSKRQFSPGNSFIAFSNRPEIASAACGSEFSKISADDVYVPPHHDSKTEGYIKLNISNLASLRQKVSTSFHIIANLPWRLAAKTECTKRTSNVKFFSVYIDCNPESESTLWSCDAVVEFRLLSHNSIISNFSRQFTNKFNYNSNNWGFPSFMEWNEILNPEKGYIREDRVVVEAYIKVQKVVGVRKNPVFDFTLSQPHISDGILVIDGLRLHVSKSYLALYSPVFHALFFSKFSERDKKEITVEDVILDEFIELLNVVYPSHKPVTAENVEFLLELGDKFEIQFVIDECERFLMRSDDIAVVTKLVWADQYCLAKLQDVCVRTFKTPNDIKILKQSEEYKNLSDTTKAALLEKIFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFJ7</accession>
    <name>A0A0N4UFJ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1113</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFJ7"/>
    <dbReference type="WBParaSite" id="DME_0000621601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000621601-mRNA-1"/>
        <property type="gene ID" value="DME_0000621601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000621601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22382" checksum="248D609E8DE7D98E" modified="2015-12-09" version="1">MIGRFVAQFASKVLSTVVDHCFDGSGVVLTPLVLLQSMLHCCLLILSDFAKCSEDFAEFESALSITVGASWSLILSCIEPPAILILYKHTLSCLLRVRLIPVARLISDCSAPTTAGAVPVAHLSSDDPGFSASFLIRARMTNMGGQKQIASLPYSKIKGIAFVDADFRLNDDFATTYARPPQSEEHISDYHYLACTFVFLLALWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG08</accession>
    <name>A0A0N4UG08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9511</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG08"/>
    <dbReference type="WBParaSite" id="DME_0000640001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000640001-mRNA-1"/>
        <property type="gene ID" value="DME_0000640001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000640001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19235" checksum="C5F906A2941D9162" modified="2016-06-08" version="2">MNDEEIHSLARIILPGIKTNSMTRIGHFFTIIEDADGFGVLTTTDDREKCNCCHQSTRQYTYSKTPLSADMNKTTSSTGKPLEGSNLTTNTNNALRKKTKSDQNLRANEVQLRILNDPTLISQQPQPTNNKVLIRIGTTTDGTKKQVVEEEGNCLKQCWTECGQCCIGILRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG09</accession>
    <name>A0A0N4UG09_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9512</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG09"/>
    <dbReference type="STRING" id="318479.A0A0N4UG09"/>
    <dbReference type="WBParaSite" id="DME_0000640101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000640101-mRNA-1"/>
        <property type="gene ID" value="DME_0000640101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048584">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21251">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000640101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52502" checksum="3192C8EA8D71CC35" modified="2015-12-09" version="1">MALSLISFMQQRCNTVNFFMRQKSIHKIQQNPLFHSSDKLFDIVGSSAELWKTVTSVSKAGQKKGRLRTRQPIRPLHKFFRIGAGPIRVSIPGLNAPLHQKEMELIEPTEDYVNEVQEKFITAIKEKSTKLGRRINKEKIHSLLRGFSGTKVAGQKLGPPPPIGDVTFDGFDSCCLVLKRTINMTTRGRKFTMNALVITGNGKGLVGYAVAKSNIFRPMAAVATALKAASRKLFHVELLEDRTIYQDFYAECRNTRIFAQRCPPGHGLHCHPRLIKICELVGIKDLYAKVEGSTTNYLALTHAFLTGLLNQETHEELAERKGLHVVKLSPHHHYLPEIVASPKYSQLKKEDEITPKEVRVYQCFTRLKLDDFYGEGRYPLKKPPKKPFYINTPGHLEAEWRKHPFRNHENAAIRLMADGLISRWTREERNNWGVKRHEMVMKGLLPVAQGIGLSDVRRDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG79</accession>
    <name>A0A0N4UG79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UNC80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9594</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG79"/>
    <dbReference type="STRING" id="318479.A0A0N4UG79"/>
    <dbReference type="WBParaSite" id="DME_0000648301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000648301-mRNA-1"/>
        <property type="gene ID" value="DME_0000648301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850584at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 central region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000648301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23466" checksum="58F6F241F3FACEDE" modified="2015-12-09" version="1">NYIAVALLETNPTSAASKDVSKPIASRISDDEVGSSFEQVRSDKGSAPSSTQGSTSKRNVPLNQPTSISCEETNDEELMLRHLPWTKVIITLLNSMNLNCNHEHYCHPRCFERVYRQCCRLTEALRKVYGEDLSMEGRIDKRKVIIDAWNSWQEDKRRAKSAAVRQAATLDKTSMALRSLLMEKLAEIEENKEWRSKVHQVSEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGD1</accession>
    <name>A0A0N4UGD1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formyl_trans_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9654</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGD1"/>
    <dbReference type="WBParaSite" id="DME_0000654301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000654301-mRNA-1"/>
        <property type="gene ID" value="DME_0000654301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000654301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12368" checksum="1A1CAA402A2DE224" modified="2015-12-09" version="1">MTDSIVATTFDFKIDDQKTLQIDDQRMQEGFIVQLAMSHKSLHKDKNQEAIDSGRIIAQRSVEILENDDEENLHNRIKKVEHVLYPEIMHRLARNFCKSKSPAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGE2</accession>
    <name>A0A0N4UGE2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Surfeit locus protein 4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9671</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGE2"/>
    <dbReference type="STRING" id="318479.A0A0N4UGE2"/>
    <dbReference type="WBParaSite" id="DME_0000656001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000656001-mRNA-1"/>
        <property type="gene ID" value="DME_0000656001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000656001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32149" checksum="849AD904EAAB8650" modified="2015-12-09" version="1">MDHFRTGGRREFLSAAEDLADDILRRTKHLLPHVSRLCLVSTFIEDGFRMWIQWNDQRQFMQVSSFLSLFLLNNTTLFVLFNFFGQIIPVIMVMIRKRVGIACAVFAVVIFSQTVAYHILWDLKFLARNVAVGGGLLLLFAETQEENRSLFAGVPQVGDQNRGKSAILLTGRVFLIFMFLSLMRFEWNFLQAVEMLVGGALMILVLIGYKTKLSAFVLVMWLFALNLYLNAWWTVPSDRFYRDFMKYDFFQTMSVIGGLLLLVAYGPGGVSVDDYKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGM6</accession>
    <name>A0A0N4UGM6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9678</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGM6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGM6"/>
    <dbReference type="WBParaSite" id="DME_0000665201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000665201-mRNA-1"/>
        <property type="gene ID" value="DME_0000665201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF88">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000665201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14355" checksum="43C1A4EE195B91A0" modified="2015-12-09" version="1">MKSFNPSSIKDALLRWCQYKLKNYPVNISNFSSSWADGMAFCALIHRFAPESFDFNMLNPKNRRANFELAFKVAEKRLNFRDHGIVPLLEVEDMLIMGDRPDWKCVFTYVQTFYKEFKNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGS2</accession>
    <name>A0A0N4UGS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF261 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9733</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGS2"/>
    <dbReference type="WBParaSite" id="DME_0000670701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000670701-mRNA-1"/>
        <property type="gene ID" value="DME_0000670701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829851at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF1">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000670701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13641" checksum="D06A1353A60B34A6" modified="2015-12-09" version="1">MRSSVVIDHFCIYSYKEIRQQFGCLSKLDSTISKKCIINCTPHNNAVMSVASNFKHLVLNGDSTMAEKYLNKSCEHVLCSLHCDIPAIAYSCGHHTANLVLNLTRKSFRSMKAMALDTGAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGT4</accession>
    <name>A0A0N4UGT4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLASP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9746</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGT4"/>
    <dbReference type="WBParaSite" id="DME_0000672001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000672001-mRNA-1"/>
        <property type="gene ID" value="DME_0000672001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000672001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21838" checksum="78842639D317AD2C" modified="2015-12-09" version="1">MAQFANGKLNLREIIGSMVQDISLVPQVLLKLSMDDVFLQKIVRGLLNKLMLEKSFHKIKQLLQSKCADLILGNCGCPRAVLEVVLNRDSSKRVMECAILLFAALYEAQETRTCAVKLTCKVLKCAKINVVHEIMNKLFGFYNIHISGSESDILKIPFDVLDLHVSMDLMPIICSYTALINGPLSPLSFSPAFSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH05</accession>
    <name>A0A0N4UH05_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cation_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS1411</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH05"/>
    <dbReference type="STRING" id="318479.A0A0N4UH05"/>
    <dbReference type="WBParaSite" id="DME_0000679701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000679701-mRNA-1"/>
        <property type="gene ID" value="DME_0000679701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN51438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000679701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41486" checksum="BA5B4181E082C35A" modified="2015-12-09" version="1">MCFGIYFLFRARIRTIMVTGDNVLTAMSVARECGIIQPRKRTFLVELLHDGAGDGSKKLVLKPSVSSSESVVDDNLSYDDLELGYLVSSSYQLAVTGFIEPEIILGPVFSLICHEYPEYVDKLVAVCDVFARMSPDQKQLLVNRLQEIDLTVAMCGDGANDCSALKAAHAGISLSEAEASIAAPFTSSVPDIRCVPMIIREGRAALVTSFGVFKYMAGYSLTQFITIIHLYWISTNLTDFQFLYIDLFLVTLIALFFGNTPACEKLHINPPPTKLLSLGSVLSIIGQLLIVFFFQSFVFVFTALQPWFNVYISKFDDTPEDKRSMQGTAVFCVSMFQYITLAVVYSKGLPYRKTIFSNWPLLTSLGKFFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH30</accession>
    <name>A0A0N4UH30_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1444</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH30"/>
    <dbReference type="STRING" id="318479.A0A0N4UH30"/>
    <dbReference type="WBParaSite" id="DME_0000683001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000683001-mRNA-1"/>
        <property type="gene ID" value="DME_0000683001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000683001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="484" mass="53833" checksum="EFE74866307DFEB2" modified="2016-06-08" version="2">MPSFWSIKNIRTQIAILLAAALCIEGLMRTNLNMAMVCMVNRTALLQLKSKVESPKNTTTVVNPCRKLPSESRKGYSGEFIWTSEEQGWIFAAFYGGSLFIVIPGSYLCDYFGPTLVVQYGSVTNIIGSFITPAVSKYGGVYPMIIVRFLMGCGQGVLVPCMTVLIAHWFPKSEKSTAIAVATTGNQLSIILAMCFTAELCQIPLFGGWPLAFYIYGVLGIGFCIAWQLYVNDIPTGSKEITDIELIYITGTLVGRGQKRLQPKVPWKKILKSVTIWSIALNSFAQSFALVGMITYLPLYYRSILNMDLTSNGVLSAMPFVIQFITKVIFASLADEAKKHGFTVNFVTKFCNLFASLGTAACYLLLMLFDCSQQWKAVIFVSLSMGLISGFIPGYNTSIVSVAPIYTSSIASFCRLWATLASIASPYLIGLLVKEVIFIIYSLIYYLFISVIKSDLSFIDIFFFRYRIDYKLVPIFCFTAYDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHB0</accession>
    <name>A0A0N4UHB0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9755</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHB0"/>
    <dbReference type="STRING" id="318479.A0A0N4UHB0"/>
    <dbReference type="WBParaSite" id="DME_0000692301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000692301-mRNA-1"/>
        <property type="gene ID" value="DME_0000692301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="4">
        <location>
            <begin position="162"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000692301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33499" checksum="DD40DCA76771E924" modified="2015-12-09" version="1">MEQSQIIASNLRAILSRIHAAAIKQKLEKRKYFRNQIPLLVAVSKTKSTELIAYGVCLFVKFYRNSCYEAGQRHFGENYYKELEMKANELQSRCPDIRWHFIGQLQSNKVGIYHFYAFISFPNNSLLFCFLIERIFHFAICNIFLFIRLILSELEGFFLLKHCLLLHEEALKRGKILRVLVQVNISKEMQKAGTTEEQAIEIAKFIVEKCASLKFSGFMMIGSIANENQDKSIEEFKKLFELRERFCHLMGLEENNFDLSMGMSNDFEIAILHGSSCVRIGSAIFGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHN2</accession>
    <name>A0A0N4UHN2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9832</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001192">
        <property type="protein sequence ID" value="VDN59859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHN2"/>
    <dbReference type="WBParaSite" id="DME_0000707101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000707101-mRNA-1"/>
        <property type="gene ID" value="DME_0000707101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229970" evidence="2">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000707101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13293" checksum="93AD0BFA14D80816" modified="2015-12-09" version="1">MFAGLLLVLASLCIHANGDDAVAIDVCNIPTPVMGAPAPVQRPSVPVDNCQDRDVLACFEIFKPQDDPGMLGMVLNQNPTTLSSPTQNCKDERQGCAAIRASNSCGGVFRITMMQQCARTCGYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ44</accession>
    <name>A0A0N4UJ44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ44"/>
    <dbReference type="WBParaSite" id="DME_0000765801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000765801-mRNA-1"/>
        <property type="gene ID" value="DME_0000765801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000765801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48662" checksum="7D778BCEB6CC7495" modified="2015-12-09" version="1">MARLAKDLFDHDEGNVETQLLKSNYLPLLLEEYLTKASFLPCLSEFFIHICHHSQIIRCEVQKLGCIETCVALIKQFREEDLLSIQSEKNRISIRHLLCKEIFDYLLSFIRGPLSKSQILVVNSLNYFVNSIYVGDVECFVNDAFNAFSQHLSAYGDDFTIPCLEKSAKMLKIGIESNRMSEEQYTIRKYCFFLHSTGCEKLSCSERDSECRVCQLVSQKQFEDFTISFLGHYGEISNRTLKYFERDELHHATFDCILKNCISSIFALATQQVQIQKRENEKGKLIENTTFKHLRELLSTLAYSSKLNINKTKNFEALIELRKAFTAICNAIKYSSIVIQKNPRFMPHWKHWKHEKYSQIGCVVQRLRKRSNKKIRFFTKHGEHIEILPRPLVLTKSKVIESGRGDVGSDSVSAPRFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ46</accession>
    <name>A0A0N4UJ46_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10094</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ46"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ46"/>
    <dbReference type="WBParaSite" id="DME_0000766001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000766001-mRNA-1"/>
        <property type="gene ID" value="DME_0000766001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843337at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36514:SF3">
        <property type="entry name" value="ASCARIS SUUM EPICUTICLIN PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36514">
        <property type="entry name" value="PROTEIN CBG00436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041159741" evidence="2">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000766001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13419" checksum="8CC09AAEDE247A91" modified="2015-12-09" version="1">MRTVFIFVLLVVTTIAKSLHKRNNQYGDEPISILTPSSKGYDAGALPEEAPAAIPTSRIPAPSLPPVESSGYRKKRNNQYGDEPAPPTEVIKPGGYEEQAEEAPAPIEQPAYEPPAVESSVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ75</accession>
    <name>A0A0N4UJ75_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10127</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001203">
        <property type="protein sequence ID" value="VDN60154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ75"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ75"/>
    <dbReference type="WBParaSite" id="DME_0000769301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000769301-mRNA-1"/>
        <property type="gene ID" value="DME_0000769301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000769301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10488" checksum="49CAB0CA37B0B4C4" modified="2015-12-09" version="1">MGVTQSLNEAHQGFLPANCITQLLTTRAFAKHSVPIQDWISAQIMECSTPLHPVIPELITAYAASCFQTSECQSSTLPLSEKFFIVGGFLLIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJH2</accession>
    <name>A0A0N4UJH2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10179</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJH2"/>
    <dbReference type="WBParaSite" id="DME_0000780901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000780901-mRNA-1"/>
        <property type="gene ID" value="DME_0000780901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790236at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229931" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000780901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13953" checksum="FD3D69DEA7632C2A" modified="2015-12-09" version="1">MHKLFIYLFINLSVSFFFNAKNKSSANDLIFFSAHGCSYAFDINSYVWSFADTKCGRLLSKFEFYFHISLFIAIISVDITTFHNKVNPHQFNPPPTSLRVVDPRKSSEASLMAVGAVEMIIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJT8</accession>
    <name>A0A0N4UJT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2068</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJT8"/>
    <dbReference type="STRING" id="318479.A0A0N4UJT8"/>
    <dbReference type="WBParaSite" id="DME_0000794301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000794301-mRNA-1"/>
        <property type="gene ID" value="DME_0000794301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF1">
        <property type="entry name" value="RE49668P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000794301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15228" checksum="67DCF9E87CC5E9A8" modified="2015-12-09" version="1">MINEGVDAIGCFVCSSFNGSNPLCEDAFNSSINSLKQKGSQRGGYGLGLANYQYPCWAFKKQRKGLFPADHCIKVSGYRKIVRISHCGHFKYDGYQYRGCVQSCDTDGCNSSNSIFINYLLSLYILFIFINRLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKQ8</accession>
    <name>A0A0N4UKQ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Filamin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10353</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKQ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UKQ8"/>
    <dbReference type="WBParaSite" id="DME_0000833601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000833601-mRNA-1"/>
        <property type="gene ID" value="DME_0000833601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="116"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="206"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="297"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="387"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="490"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="606"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="683"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="808"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000833601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="902" mass="97476" checksum="5572D703A8E664C6" modified="2015-12-09" version="1">MRSKLQCVEEYSDLKLSVLKRNDDFEPSEFIPNGKHRSSISERDIVFTVGDIQKRVFDKLRAVVTMPSGKKDSAIIKDNHDGTVSVVYQPTNIGHHLLSVQYDGVNMIGSPMSFFVDDIHEGLITVYGPGLSKAVVGEPAAFTVCARGPVAKELSVSVEGRGKATIKCHDNKDGTCSVAWVPPVPGEYKIHVKIGGKPVKGSPFSVFVAGEGQKRAHLSVGSTSEVSLNVAADELKGLSASIKSPSGIEEPCFIRLIDHSHIGVSFTPREAGEHFITVKRDGNIIPKSPFRIKVDKSQVGDASKVIVSGEGRAQAICQKFNDILVDTRQAGYGGLSVSVEGPSKAELICKEAKNGIIVISYRPTEPGIYIVSIKFADLPVKDSPFTVSCTGKGIGAVKEIIQKEVPQASISLVGQDAFLFLQLSNTSPMEITARITKPNGQSEDIEMRDLGNNFYQLKFKPQMEGAHAVSVYHREQHVAGSPFQYTVGHFEDYGAHRVRAAGVGLLRAETNVKQSFNIYTREAGKGDLVVSVEGPSKPLLEFHDHKDGGCHVDYKVSSPGEYLISILFNKEHIPDSPFKVVFVAPATGEARRLELASFPDSGMPEKACTFTVLTHRAAGHLEAKVQTPSNNIETIDIVPIDEGESYALRFIPHEVRSGNYYIDVTLDGAPMRDSPFRLRIGAKGDSDPTAITVCGDGIRSGQTGQKCEFIVNTINAGSGLLQVQVDGPSKVTLDAYELEHGYKVRYMALAPGTYYAAIKYSGVHIPGSPFKISVQGNELGGTGEPETSLIKIDAPAKTSKGTVIQAPVFKSDASKVSVKGSGLNKFFPGRPAIFNIDTAMAGNDLLFVGVVTTKGPCDEVSVKHQGHGQYSVTYRIQERSKGFIFVKYGDEQIPGSPFAITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL45</accession>
    <name>A0A0N4UL45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ran-GTPase activating protein 1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL45"/>
    <dbReference type="STRING" id="318479.A0A0N4UL45"/>
    <dbReference type="WBParaSite" id="DME_0000850001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000850001-mRNA-1"/>
        <property type="gene ID" value="DME_0000850001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000850001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50379" checksum="108ED5B3898805A3" modified="2015-12-09" version="1">MPDLTETNGSSTFAQDKRSLCSAMISSGCHLVELDLSDNAFGSVGAESIENFLKTAFTLRILKLNNTGLGRGLIIIANALKKCILNANRLGKKFSLQTFIAGRNRLEADGAVALAGLFQMIDSLEEVDIHQNGINSEGIIALSSAFKCNPNLKMINLSDNTFNETGAKAVAEVLQFLQRIEILNFSDCLCRNTGALAIVSSLSSSIHLSLKEINLSGNEMDYETVKAVINAMDNSGFHLKSLILHTNNIGEQFQKLKEENVHKDFINLGTESDDQGSLDGEDVVYQSDSDGDEKGPLCENINGSRNFDFGSVDKEILEFIEHPNVTHVFKFLEKKNFLDFIKQDLKGRFQKTTAAFLFALSSLITTANQNDAHFMMAITDIADSILSLAESLLRFPLSPSEQICNLLLAFAGGVPVTTMQFGRKIQYIIKAYLDILRCIFAVLNQKVGSMIKSNKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULD3</accession>
    <name>A0A0N4ULD3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2519</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000065">
        <property type="protein sequence ID" value="VDN52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULD3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULD3"/>
    <dbReference type="WBParaSite" id="DME_0000860401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000860401-mRNA-1"/>
        <property type="gene ID" value="DME_0000860401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000860401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12736" checksum="F1B0C6333BC16FAA" modified="2015-12-09" version="1">MASNLFDTFHNWFFLIQFLLPYSFNAVLIQISYATNINGVNSEKTITVLNGTTTMLNCEPAENLIRAHMAPDFEKPQLIRKLDWFLDDTIVASYQQVSDFLEFEKCFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULP0</accession>
    <name>A0A0N4ULP0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10456</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULP0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULP0"/>
    <dbReference type="WBParaSite" id="DME_0000872301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000872301-mRNA-1"/>
        <property type="gene ID" value="DME_0000872301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000872301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="628" mass="71504" checksum="4F3CA7C7240649BD" modified="2015-12-09" version="1">MARGPKRHLKRLAAPHHWMLDKLGGVFAPRPRCGPHKLRESLPLILFLRNRLKYALTYREAKLICKQRLIKVDGKVRTDMRFPAGFMDVIRIDKTNETFRLLYDAKGRYATHRITGAEGNFKLCKVVKKAVGPKGVPFIVTHDARTIRYPDPHIKVNDTVIIDISTGKVTDYVKFDQGNLCMVTGGHNMGRVGIVGHREKHPGSFDIIHIKDIAGHSFATRLSNVFIIGKGTTALVSLPGPTKVLNGIICVHIPAVEGLNYVKKRIVEAICEGGNRSIPEIRLPVINMPVVEAHHKSQALIVVGWKKQSDYSLHPLVIGEPFRAEDIQIEELHNTGNFSSGVGIFGVNNGCDQFDDILSYGWLNEYDIRIKLGHSTTDGSNLSPVKETCDFKLLYILDHVTRHKIEELLSIIETRYKKLSFELANVDLQSQEAFELSRKGPLRQRILKAPMIYSIVLNSFNPPEFTLTLTSIGETETFFFDFVREIGLNLGIFMFNHSTFATCCGIKRRRAGPFDDRHSLLIKHLSVRNIMLNMARSHKLIDYYRKNVNSNVIQKMDEINIDEISENQLTEVLGDLQEAEVDENCIQMSFDREYTTINNFLVIFSKFFLKTECYSFRNFISIFLILIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMA5</accession>
    <name>A0A0N4UMA5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10520</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001222">
        <property type="protein sequence ID" value="VDN60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMA5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMA5"/>
    <dbReference type="WBParaSite" id="DME_0000896901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000896901-mRNA-1"/>
        <property type="gene ID" value="DME_0000896901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="11">
        <location>
            <begin position="23"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000896901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32053" checksum="9DA2FB76A43D0120" modified="2015-12-09" version="1">MYVKGGHQWCDKKKYRSNLPNTTVIICFHNEAWSVLLRTVHSVLERTPEHLLTEIILVDDFSGLDHLKRQLDDYMNHFRKVRIIRLESRLGLIKARLRGASKAVGTVLTFLDSHCECAEGWLEPLLERIAENPTNVAVPTIDTIDLQTFEYRYSNYSRPNVGGFSWGLIYKWHRLPDRDYKAMKTRIDPVPSPTMAGGLFSINREYFERLGGYDPEFDIWGGENLEISFKIWMCGGRLEIVPCSHVGHVFRKKSPYKWRNGVNVLQRNNVRLAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMC1</accession>
    <name>A0A0N4UMC1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10539</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001223">
        <property type="protein sequence ID" value="VDN60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMC1"/>
    <dbReference type="WBParaSite" id="DME_0000898801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000898801-mRNA-1"/>
        <property type="gene ID" value="DME_0000898801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425681at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000898801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17709" checksum="21759FF2F582FE8B" modified="2015-12-09" version="1">MDAFELQLWKKNIPENVVESKRKRCIKKAEVFIRATTDLKLSYFGFIMRRFSSLEKDLRMARKDKKRTKEDLHQVTNRGLCDISLEMCTSIRCVAKEGVIHPRNELKAFCKSIIMLVLKSLKAVHYPLSRKTIYLNPNYILIILALQTKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMC3</accession>
    <name>A0A0N4UMC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2793</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMC3"/>
    <dbReference type="STRING" id="318479.A0A0N4UMC3"/>
    <dbReference type="WBParaSite" id="DME_0000899001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000899001-mRNA-1"/>
        <property type="gene ID" value="DME_0000899001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="78"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000899001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="33191" checksum="D6EFE7ECCB2980A5" modified="2015-12-09" version="1">MMMEDQTTNKPAFDDVSTIDVPPNFDNYSSNTTHRPSIGELIGNKKIAPFMEKPQITIAKELSEESENGDVRFGWITGVFLRCVLSILGATLFLRMGWMSGQTGIILGTSLILISSIVAILTAISMSAIATNGEISRSLGPEFGGSIGLIFYIANLVNASMNCVGLAESIVFLLNENSWSLIDGVICLILQCIIFIGTAFESKTQLVFLFSLLISVITYIIGTFFPSNDYRLNRGITGYSARTATSNILPDFRSGETPISIFGVYFPTMAGMMAGANMSGDLKDPSTSIPKGTILAIITTSCKIFCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UME7</accession>
    <name>A0A0N4UME7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc transporter 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10565</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001225">
        <property type="protein sequence ID" value="VDN60592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UME7"/>
    <dbReference type="STRING" id="318479.A0A0N4UME7"/>
    <dbReference type="WBParaSite" id="DME_0000901901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000901901-mRNA-1"/>
        <property type="gene ID" value="DME_0000901901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052005">
        <property type="entry name" value="CDF_SLC30A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531:SF1">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="368"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN60592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000901901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45571" checksum="C2F268F3472E7082" modified="2015-12-09" version="1">MGGLVIDWSNTNVRQACIGAAACVLCLFFLIGCVSVTRSLVLTSAAWLSVFSFFSLISSVISLSVTHKPSASYTFGFARAPVLAVFSTTVLASLSSIFLVKECAEHLLEGDHHLHSQGLYLFGAIAASVSLEIAAYGVRNQPIQHVITASSSSSLQEHFADVSHAICYLIPGLSAFLLPRLNALTILAFLTSTACFITHWFSSELWWIDAASALILSICVFITMWPLSKYTGRILLQTSPPHVHNQLDRCISEASTIDGVLELRNAHFWQLDFLSMAGSVDVRVRRDADEQLVLTRVTEKLSSVVSILTIQIVKDTGISWHNQNKAFISHISSSPNLSTINISPSGNENAALISPQIYYNSHHILHEHEHKHEHEHEHGHGHGHEHEHGDGHGHRHGHEQVDGHGAVHDPHVTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN54</accession>
    <name>A0A0N4UN54_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDC48_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3041</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spirurina</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000099">
        <property type="protein sequence ID" value="VDN53068.1"/>
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        <property type="gene ID" value="DME_0000931901"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000931901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12528" checksum="76D2AC9D2AFC86FF" modified="2015-12-09" version="1">MSEKTRSAVIEWKAVNDRMAYARFERKFCNISVISVCAPILCADDCDKNKFYAELQPLTTSLSRGDMVIIEGDWNDTVKMNSIIGKYGIEVQCVNGECLLAEVHELFVINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNA1</accession>
    <name>A0A0N4UNA1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000103">
        <property type="protein sequence ID" value="VDN53112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DME_0000937401"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
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        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000937401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25944" checksum="C17F6461BF57FEF9" modified="2015-12-09" version="1">MYESSELLHLNAKEFHLKNCNIPKTNFKTKNDHLIFTVGTICYLISNKEKGSNLREIFAENNENEAPAMNCEISEEIIKCSSGNGHALLLSSLGEVYSLGNGNHGELGRGSFDNQEIPKKIEFLSSLKIIDIACGSWHSIALSDDYNVYVWGWNNFGQLSNISSLVNIPYPLEIDDEIIAVDAYRNCTLLYTANMTVISYGSFVFHNNPNFFYFFFSKQFHFRSLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNY5</accession>
    <name>A0A0N4UNY5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3298</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000120">
        <property type="protein sequence ID" value="VDN53325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNY5"/>
    <dbReference type="WBParaSite" id="DME_0000964801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000964801-mRNA-1"/>
        <property type="gene ID" value="DME_0000964801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000964801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19582" checksum="5F554D05944D408B" modified="2015-12-09" version="1">MALKKVAYGAVSNNDVSYSNKTIEDLRSVFIIEKYEKQQDLIMHLTRSVEILTKKEKEPCLVGINIPEKSTDDESATADMLLAENIVVVAGFKTEFIKEVRRHGRKGTGRPRVLKIRLEDKQMAISVLRNKDVRSIVLFPLEVPLEVFPLEFPLGNFLRKDLTKRELLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNY9</accession>
    <name>A0A0N4UNY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3303</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000121">
        <property type="protein sequence ID" value="VDN53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UNY9"/>
    <dbReference type="WBParaSite" id="DME_0000965301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000965301-mRNA-1"/>
        <property type="gene ID" value="DME_0000965301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842105at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="3">
        <location>
            <begin position="170"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000965301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="459" mass="52687" checksum="BF7519CB598D55B9" modified="2015-12-09" version="1">MELSEEGKSSSLLDESQNDNFTEVCSPSRSSQHEEFNPDAEEISTDCRNGSSMSGTDHVEFSTDSKEKEEKRKRQCIYNASKMIDGIIVEQCSSTANEVIFTNDEKQTLDVDDLIVKDEYLQTRRRYSLSLPKKPVTYPRRVGSCDLLNISRMNFSTCGESVEIIALLHKAVFFLARACQKNIDIAKNKCLWTTSPQNEDLLREAFRKSSVVILIFLAKGTNHFCGFARVCSEALYHGQPALQWVDFSGGGNIEIKWISKKSVLLSETDHIKNPFNRERPLYIGLDGSEIQRQAGQKLCYMFPFDETVDFRNVLNINSGRLCSKKRERTGTGSGTNRNSLPSLFDFSISYDQFKKARREVDQMDVLPWERVPPMQTRRNSREPPAQAQVYPVPLMDLHFDGRPVSYRVECSTEKYNRYASSPYPSPSRRLVGYIFGYLYLGYFFCFTNTYVQLYGIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP82</accession>
    <name>A0A0N4UP82_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glyco_transf_7C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3368</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP82"/>
    <dbReference type="STRING" id="318479.A0A0N4UP82"/>
    <dbReference type="WBParaSite" id="DME_0000975201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000975201-mRNA-1"/>
        <property type="gene ID" value="DME_0000975201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000975201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24548" checksum="5198E54DC042D2B6" modified="2015-12-09" version="1">MHSFLKRQNLEYAIIVVNQTKGEIFNRGKLSNIGYVEGVKLYDWDCFVFHDVDLLPENSRNIYTCSDNPIHLTAAIDLSNYKLPYYTIMGGAVVFTKAQFLKINGYSNNYWSYGGEDDDLTGSCRFYILQKTFEMWHEDGLSNLDYEVVHNEKLQLYVNLVVRLKEKESIAILEGRKDYEKYKRCAKLVNFLKKLIHQIIPTFRQIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPN3</accession>
    <name>A0A0N4UPN3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3484</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000139">
        <property type="protein sequence ID" value="VDN53511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPN3"/>
    <dbReference type="WBParaSite" id="DME_0000992701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000992701-mRNA-1"/>
        <property type="gene ID" value="DME_0000992701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000992701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15292" checksum="7FBD72176F9AA2C0" modified="2015-12-09" version="1">MWDLRKKDINARITILSWDDNSWEIPFDDQNTDIDWSNSPLNPIKQLTTKKILRQKGFDAIRRDFKMRYNDMVEKKRDDRIAFKPLFSTEKINEDPPFELNYAFSFMHGRKSFFFGFSSFHKSGIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPV8</accession>
    <name>A0A0N4UPV8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase omega</fullName>
            <shortName evidence="6">GSTO</shortName>
            <ecNumber evidence="6">1.20.4.2</ecNumber>
            <ecNumber evidence="6">1.8.5.1</ecNumber>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3551</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="6"/>
    <dbReference type="EC" id="1.8.5.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000148">
        <property type="protein sequence ID" value="VDN53578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPV8"/>
    <dbReference type="STRING" id="318479.A0A0N4UPV8"/>
    <dbReference type="WBParaSite" id="DME_0001001601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001001601-mRNA-1"/>
        <property type="gene ID" value="DME_0001001601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041159901" description="Glutathione S-transferase omega" evidence="7">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="120"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001001601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27055" checksum="36597582D3E7EBA2" modified="2015-12-09" version="1">MSNLILTMFIVNQITIIEGSVEPAASPGTLRLYSMRFCPYGQRAVIYAAKKRLPVEIINVNPDNGPDWFLKKSPLGRVPAFERDGRVCIFPLIQMTIYESPIVVEYLDDIFPETSVLPRDPFAKAEQKILLERLSPLISTLFEFLRSKNASDQREADESLNKALRNAELLLANNYYGGNGMGYVDIMIWPFFERLQLFTMNPLSEFRYFPGQKYPKMGAYMARMQQQPEARFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQA6</accession>
    <name>A0A0N4UQA6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS3694</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000169">
        <property type="protein sequence ID" value="VDN53721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQA6"/>
    <dbReference type="STRING" id="318479.A0A0N4UQA6"/>
    <dbReference type="WBParaSite" id="DME_0001018401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018401-mRNA-1"/>
        <property type="gene ID" value="DME_0001018401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="107"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN53721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22571" checksum="888D09BC1B8CC578" modified="2015-12-09" version="1">MPVISRRCAHTDVSIPNFDAYRSKSALDSSKAARESEDIRRATPQGIFYGVGGAIALLAAKEIVQKTVIFKSMAADQLALASTEINLDEVPLGQTKTFEWQGKPVFVKHRTEDEIKREKEVVVSELRDPEHDDQRVQKDEWSVVIGICTHLGCVPIANAGDFGGYYCPCHGSHYDGSGRIRRGPAPLNLEVPKYKFKDNSLIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQA7</accession>
    <name>A0A0N4UQA7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PUA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3695</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000169">
        <property type="protein sequence ID" value="VDN53722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQA7"/>
    <dbReference type="STRING" id="318479.A0A0N4UQA7"/>
    <dbReference type="WBParaSite" id="DME_0001018501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018501-mRNA-1"/>
        <property type="gene ID" value="DME_0001018501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000001">
        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20682" checksum="A9D2922FC60A03F7" modified="2015-12-09" version="1">MFKKFEPKEDIVGVQQLKSSAQKQIRAKILEQYPSLESYINEILPKKESFKLVKCKDHIELIADFEGNIIFIKPRDISYIPSLRLLHKYPFMMPHQQVDKGAIKFVLNGSQIMCPGLTSPGAKMNEDIPKDSLVAIMAEGKEHALAIGIMKLSPEEIRSVNKGIGIENLHHLNDGMWKLATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQB1</accession>
    <name>A0A0N4UQB1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3699</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM63 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000169">
        <property type="protein sequence ID" value="VDN53726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQB1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQB1"/>
    <dbReference type="WBParaSite" id="DME_0001018901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018901-mRNA-1"/>
        <property type="gene ID" value="DME_0001018901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140934">
        <property type="term" value="F:histone deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27891" checksum="91317DF407C52F15" modified="2015-12-09" version="1">MLFLGQISFLNGWNRVTETDLLQIIADCILRFRPKNLSESDELNYEQNISDVLSLVPSLPRGLDVNLEFTGVRKFEYTTASALFDLLDVSLLHGWIIDPQQTELVKLLNGISYNKLVEKVINLDDSNSESKLLRNFMENSSSQLTVHGLCELSLSLTDGQIAVLFRNNHFHTLYKHRDELFVLVTDMGFLNEPSVVWETLNSVDGDSFFVDANFHTSLQTTKQDETAEYNGLLFLYIKNNLYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQJ8</accession>
    <name>A0A0N4UQJ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TROVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3785</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000186">
        <property type="protein sequence ID" value="VDN53812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQJ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UQJ8"/>
    <dbReference type="WBParaSite" id="DME_0001028901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001028901-mRNA-1"/>
        <property type="gene ID" value="DME_0001028901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6098064at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056800">
        <property type="entry name" value="vWA_Ro60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25045">
        <property type="entry name" value="vWA_Ro60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="7">
        <location>
            <begin position="54"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001028901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60686" checksum="005386D6A580B38F" modified="2015-12-09" version="1">MGKLSLKELLKGVINENDQIKSDDLDKLIDRLEILGKKVESEYVPRSTTRRSKVQNYAGGFVFRTNDENIVRRFLIIGSTTGTYYVSGHELTLERAEHLCDLIEQGKGPLILRELVDISLAGSAPKQESTLFALALCARYRVCRIPTHLFTFLNYCKVIAMRTGSKKHSTGFSRAFRAMIAKWYYDYDPERLVMHITKYGSRSGYCHMDLFRLSHIHPKISFPNEHNYLKRAFLDFCIFRISSCWEWKIQRIEQLSGFVHEHVPSHLLNYKEVWTALLKDMPMTAFIRNLGKMTAVGVFDEKDSCALAVSYLTNQEKLRNARIHPLSVLVALSAYAFKSGDCLGKVECIPNEEICSGLSKCFELTFVNVNPTNKRYCVGLDVSGSMYQPASPTSTMNCIEVKTMVFASEFEEIFFNSNWTLQEVLGGKYKNLVSIDFGSTDCALPMIWALEKKEEFDVFIVITDNETWAGSVKPCDALCNYRKEMNIPDAKLIVLAMTATNFTIADPNDSNMLDIVGFDPSIHEMISKFVLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQK5</accession>
    <name>A0A0N4UQK5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprotein allergen nematode domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3792</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000187">
        <property type="protein sequence ID" value="VDN53819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQK5"/>
    <dbReference type="STRING" id="318479.A0A0N4UQK5"/>
    <dbReference type="WBParaSite" id="DME_0001029601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001029601-mRNA-1"/>
        <property type="gene ID" value="DME_0001029601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823468at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.30">
        <property type="entry name" value="Nematode polyprotein allergen ABA-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032487">
        <property type="entry name" value="ABA-1_nematode"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038289">
        <property type="entry name" value="DVA-1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16469">
        <property type="entry name" value="NPA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="1">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="1">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001029601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45244" checksum="46CFE7DF1B5205D9" modified="2015-12-09" version="1">MKKEGQSIKMMQDKIMEYLKSLSNEKKANANEHLKSACVELVKNVVGDEKAASLKAMRDSGAKQKLTEMLKDVNDDKKNLADNYGDFCRNLYWLDVHHRKRRDHHEDHHHHGLEEYLKTHLSWLSEDQANELRKMKKEGQSIKMMQDKIMEYLKSLSNEKKANANEHLKSACVELVKNVVGDEKAASLKAMRDSGASFSQLEQKLTEMLKDVNNDKKNLADNYGAFCRKIFDAKLRQRREHPDSLEKYFSKLLDWMSKEQKEELKQLKAAANLNIVQSKIIEFFNEASGEIKELATKSLQQGCLALIGDLAGNKKVIELVAMKDSDVTREELEQKIGDIFENISKEHQNSPVLGYEKPCKIIYGIGSTRKRRHLNENNLNNIIRSNKVWLSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQQ4</accession>
    <name>A0A0N4UQQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10886</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001266">
        <property type="protein sequence ID" value="VDN60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQQ4"/>
    <dbReference type="WBParaSite" id="DME_0001035701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001035701-mRNA-1"/>
        <property type="gene ID" value="DME_0001035701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039255" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001035701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8057" checksum="F6F4CEADCCF994C9" modified="2015-12-09" version="1">MLLYFCFFVFLVHGVKSGDDKAIENCNIQVGGHQRPIVDPSRCAHIDSPACTAIFPYHPANRAGETIATHFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQT5</accession>
    <name>A0A0N4UQT5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3860</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000203">
        <property type="protein sequence ID" value="VDN53887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQT5"/>
    <dbReference type="STRING" id="318479.A0A0N4UQT5"/>
    <dbReference type="WBParaSite" id="DME_0001039001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001039001-mRNA-1"/>
        <property type="gene ID" value="DME_0001039001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000525">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0001039001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14762" checksum="661249444BBDF931" modified="2015-12-09" version="1">MKNRATKKKGRGFGAETHAGITEYDALEGTGSADGPQRSVEGWIIFVTNINEEAHEDDIHDRFADFGEIKNLNLNIDRRTGFLKGYALIEYDSQKEAAAAIEGMNGTDFLGQTVNVNWCFVRGAQHSRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR70</accession>
    <name>A0A0N4UR70_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3976</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5alpha-cholest-8-en-3beta-ol + NADP(+) = zymosterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16608"/>
            <dbReference type="ChEBI" id="CHEBI:18252"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.72"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:36401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>lanosterol + NADPH + H(+) = 24,25-dihydrolanosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33919"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:33920"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000235">
        <property type="protein sequence ID" value="VDN54003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR70"/>
    <dbReference type="STRING" id="318479.A0A0N4UR70"/>
    <dbReference type="WBParaSite" id="DME_0001054201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001054201-mRNA-1"/>
        <property type="gene ID" value="DME_0001054201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="45"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001054201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="59091" checksum="0F1FC32A12ECB075" modified="2015-12-09" version="1">MKNKMLFSFLIEWIKFRFRWIVIIAVIVPLSFFYNYYLSIRNNIMNTLGIAIKVHARKVNELRKEEAKSLKMCSGRSKWEATNFKCIKYKETLKNISIQQLKDILEIDLEKGTAKVEPMVTVNQLMKYLLSIRYTLPIVPPLDDLTVGGLINGGGCGAGSHKFGFFHNICISMEILLADGTTIIASKVSFSTDGESSLDQSLFFALPWSCGTIGFLLSATLKIVPYQPFVQLTYRKCSSLSVMNVIKEESDNPENNVVEAIQFSQNKSVVIYGKFIQALPKNTKVNEFGKWYKPWFFKHIDQFMTDIEKVEYIPTKDFYNRHTRGLFWLLQDIAPFANYALFRYLFGWMFPPKFMFLKWFKSQLLCSFYSSLCLHYIFEDMLVPFSDFKPFLNLVISECSIYPLLLTPCIVSSLPGIIRQQKGENVLYIAVGIYGFITTNFSPTRAIKNLEKYLRVVDGFQMFHGDINMSRPEFWEMYDSSLYDYVRSKYACCQGLPDLYEKVYRNAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR83</accession>
    <name>A0A0N4UR83_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3986</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000239">
        <property type="protein sequence ID" value="VDN54013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR83"/>
    <dbReference type="STRING" id="318479.A0A0N4UR83"/>
    <dbReference type="WBParaSite" id="DME_0001055601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001055601-mRNA-1"/>
        <property type="gene ID" value="DME_0001055601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862080at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001055601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="773" mass="89469" checksum="4995A9D2D926A8B5" modified="2015-12-09" version="1">MASQKMAGGGTEQEKLVLDKRTVNSHKECQVNIISVNSAKDDANVTGRLTFNSKRRKCKCTNDGEVVVKKSRGQEHLSAELSKDVGETSDYQFNRINAKKKFDFLVSESFKTFENESKDLLVDDVHLFNIIKSVDIGSIKNRRAALQCEYSALTFITGGALRLHRTSHQYDVGNTLEKVVYGVPLNATFYICRLCCLAYENNSIYQKHMHIHGSIFNCLHCSAVAFNVAAMKFHESLHLGSSSSDRLIYICSICMTAFSIEERLYHHMQKMHGQYLLYFCKVCGLANSDGQIVYSHIAKKQCKDEVLDSVCQMGFVAACIFHFQPADPQKYEFLQNNGALAVIVPSECLHRSFLSQSSTDLFFITCTTCKSLLLNLIYYMASKKTNFIRAPDDNSDTIRILTAAWETKNEHMLSVQPILPVSSSIHGTNSSLSAFVEEKQTTINDPSTVAVDLNVASINNMIFQIYLIYEMCRDIYLQWKMMELPVQEREAVEFLQCHGILPQTMACRKGHAAKLHFCKHIYWKCAKRTCQKKMRVRSRTWLEGSRIPITTIIRFIHCWCQESNSIDWCQRELKLSKDCVIEWNNRMREVCVSAVQRNKKKIGGDGLTVEIDDNLFNKRRNNDEKPLPEHWIFGGICRETRDMFIEEVPDRSANTFLTFIKKNVEEGSIIYSDFLRSYKIEELNEAGFEQLKVDYRYNFVDPKTGLLTRHIEKLWVSWNRRNRRTIRHHLDTYLAEFLWRQNLRDENVFYAFLREVKEFWPPAKEFWPSTKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US66</accession>
    <name>A0A0N4US66_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside-diphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4290</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000605">
        <property type="protein sequence ID" value="VDN54317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US66"/>
    <dbReference type="STRING" id="318479.A0A0N4US66"/>
    <dbReference type="WBParaSite" id="DME_0001089801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001089801-mRNA-1"/>
        <property type="gene ID" value="DME_0001089801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001089801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20898" checksum="FECED0EAE2F94D55" modified="2015-12-09" version="1">MKLFPAKTSANNSKGKNGNCLASRKSSSDLKTLVPSADASAISPDEIVSADVSSIITVEGGKVDTDHSTIAETQNSTTSEVSPKELLKNSLIILIIGPPGACKNEIAQLVAVKYGFFYISMGESLRQKVSKNQDDELWKKIGEKMNIGDPIPMKICRNVLYNEMLENGSQNSGFIIVGYPRTQQQAKDFLAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USC2</accession>
    <name>A0A0N4USC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4344</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000871">
        <property type="protein sequence ID" value="VDN54371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USC2"/>
    <dbReference type="STRING" id="318479.A0A0N4USC2"/>
    <dbReference type="WBParaSite" id="DME_0001095401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001095401-mRNA-1"/>
        <property type="gene ID" value="DME_0001095401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001095401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7060" checksum="D9540A9743F73C76" modified="2015-12-09" version="1">MDAQYKEGLIISLSALAAGTFIYVTFFEVIATERVNEYSNLAQLAAIIAGFSTVAAFQLIEIIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2K8</accession>
    <name>A0A158Q2K8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4689</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2K8"/>
    <dbReference type="STRING" id="318479.A0A158Q2K8"/>
    <dbReference type="WBParaSite" id="DME_0000032901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000032901-mRNA-1"/>
        <property type="gene ID" value="DME_0000032901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912041at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="183"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="413"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="487"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000032901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="558" mass="65563" checksum="657544A5C1084410" modified="2016-06-08" version="1">MHSYGYYFYLCVIIAFIQLMFYHIFKDFINRSLSTTDLIRFRPWKRNAAIKLSPSIFAWTRFCGNDFNDIIETSLKNCKYKCMVLRNKREYLSAGAIVFHIGETFMEKLPRKRLTNQLYIFFNMESPFNTNRLAHALANFFNITMTYRLDSDIFSGYGAVRKIDNSTDKQDIWAWEQVEKIVTNKSKSALQFVSNCYASSGRRHYVNALAKYINVTRYGYCTQNFCNDSCEKEAVEVTLDIAQHRFYLAFENSVCRDYVTEKLFKRMEQLLIPIVLKKSIYKRILPPGSFIAADDFLSPEDLAHYLLYLEKNRTEYMKGSFCYFRYFQWTRTHLKSTAVPEQDGFCKLCKMLHRGLDRPHIINLESWWYKEGHCLMNYAGSLLLGLKEESTISTNANGSLCNNILINELYLSKYLLAGAIIFHNRNISPLKMPNERHADQLYAFLNMESPSNSFSMPERMNWHYFNVIQVEWLSTNFFIVSVTKIVNNKTKSVLEFVSNCNAISRRDLYTNELRNYINVSVFDSCSAKTCNKRCEQIAVGMFQYYFSNISNERAYTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2L7</accession>
    <name>A0A158Q2L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase_GDSL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4753</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2L7"/>
    <dbReference type="WBParaSite" id="DME_0000039301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000039301-mRNA-1"/>
        <property type="gene ID" value="DME_0000039301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000039301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43136" checksum="0D89D8134DD00FE5" modified="2016-06-08" version="1">MLSCHITFPLHLHIYTLSFKLYAHDFVFKPIYRMKFRAKLRKFFNIHCVFLSTTENLLKQQENDHSFIIIPFVCTTTRYVVTLKGWANTSNKIIMNGRTVISVRDYWIASIGDSFASGEGNPDIPAGLMNMVPAKWISDQCHRSSRSWAFKVFEKILNETHDDAIHFTYIPCTGASVDNGILISAKGDSQMDTVLRISKLRGSGPDLLLMSVGGNDIGYSEILSSLIWGKTTTLFETIDMRFFYASYQFDRLALTLKKIKPSQIVIPHYFDLTRNERGIIDADCAEMRQIRTENLILAEKKILQRINKLISKKAQLYCWTVVDEVAELFRSRGSVRDSLRLQGNSFGAFHPIEEAHQSIADLIWNKLKFQFHYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q394</accession>
    <name>A0A158Q394_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6272</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q394"/>
    <dbReference type="STRING" id="318479.A0A158Q394"/>
    <dbReference type="WBParaSite" id="DME_0000191201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000191201-mRNA-1"/>
        <property type="gene ID" value="DME_0000191201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250578" evidence="6">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000191201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34667" checksum="A81CA9F7B83E14ED" modified="2016-06-08" version="1">MICWIRFIIFFIPPFICSCFSEIPQKRFPKAIIIGVKKAGTRALLEFLRLNPSIKAPGPEVHFFDRYFDKGFEWYRNQMPLTNSSDITLEKTPAYFISKTAPERVWKFDKNMRLLVVTRNPITRAISDYTQALSKRKKGSILPTFEKMVFSNETKGLPSRRKNNQLDRKYGVNSSWGAIRIGIYHRFVKRWLQFFPLEQFHFVDGERLIINPASEIRIVEHFLGVKPTVQSSNFVTDPIKGFPCVLRLDNTMHCLGKTKGRAHPQVREDVLKKLRAFYAPENEKFFKLINNRFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3I4</accession>
    <name>A0A158Q3I4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6816</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3I4"/>
    <dbReference type="STRING" id="318479.A0A158Q3I4"/>
    <dbReference type="WBParaSite" id="DME_0000245601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000245601-mRNA-1"/>
        <property type="gene ID" value="DME_0000245601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069252at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005668">
        <property type="term" value="C:RNA polymerase transcription factor SL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="11">
        <location>
            <begin position="383"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000245601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="859" mass="99696" checksum="3D6BD0C0063C37B3" modified="2016-06-08" version="1">MYYILELEITSTASLAASKKLMQRLKIGRAIFQIQRELEDDNGFYFTGLTKKLATQSQHQIVGDKRKKKTHETIHEDELGNLAGISDEDYPHFLNKAGSRLATASKLLSRFSNKLIMDCGVPNTARDHCLHIFQLYLKHFKVAFCEDELDVSNPFCPIVIEQKYDEIKQNKNEERKAKKEHDISKGVNVLGHIFDMNVEIEDDAEISAFTELRTKLSKVAVKHLLLIPFTSEVMIVILYLACICSGATWILLSDITRWFREGRLRRTLHQRCALAVPCSAKKDENCNNRQIYPLFEYIRVLIALSQITEIPKQPVLRNIHQVISRFCFNLNLPYAFAHRVHRLCDTLKPSTEISAAITRRFGDFDSSEVLDNANANFNNYFSTGFEKRCQRSDFRKYSVLPSIEAKALALILFAFKLIFGLDGHREFNMVPQNSNDVFNFSSWFHQLKMRMEVWRGRPVQNVLKVRYRTLPSYDAIHADYRTMYRNADFNQISHSLLFTKRNGYFSGCIPNYVVQEAKDYALLKVFSDNNDEMPAKFTDKEAILTPLCFQATKNQEWFRNQRKKASFRADSIDYYNADIFFADFKSYTLDYHTVDANVDSTSNQKQVFPRPHYCGSLMRCDQSNIMYFPIIYTCAMDAVLSVAHRHFSDTFAFLFETFCLLIGEEQKVLYAFFLMIEMICLSRDRLEEIYNLADTGAEISMKGQCIDIFSRPNQYFLRLRRMPGDMSRADYAYNMITIDSILPEPSTVFVPFHVSIANLKKKYQKKNYEEESASQPSQEEKYFVEKKRRKRGERWILILTWLLVVNVHTLMKVNEGNSVPTFPISPFDIPKKEIPGSSAVEIGVDPSRFLALRCPKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Q7</accession>
    <name>A0A158Q3Q7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS166</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Q7"/>
    <dbReference type="STRING" id="318479.A0A158Q3Q7"/>
    <dbReference type="WBParaSite" id="DME_0000293701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000293701-mRNA-1"/>
        <property type="gene ID" value="DME_0000293701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862686at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040655">
        <property type="entry name" value="TIAM1_CC-Ex"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18385">
        <property type="entry name" value="Tiam_CC_Ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIAM1 CC-Ex" evidence="1">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000293701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25042" checksum="B054C0133C3B64EF" modified="2016-06-08" version="1">MRFVRGRSNSEFELKCFKTIKPFVIKFILAESIIVIGEIKERLYISEPNQIYAIECGNYEITRYLSMKLLKISSFSLSKTFNVANTAHFLQKQISALNNNINCVICRLCTSLATDYWIATIYWIQNIFRHLQSMAALQSDCALARDMKEELEMFHLKVFAFKYRLAAICDVAFPSPSDVLSKISVETLRNLGTFGSVAICSLHLYFISKYQFKMFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3X2</accession>
    <name>A0A158Q3X2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS247</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3X2"/>
    <dbReference type="STRING" id="318479.A0A158Q3X2"/>
    <dbReference type="WBParaSite" id="DME_0000338101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000338101-mRNA-1"/>
        <property type="gene ID" value="DME_0000338101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000338101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="66833" checksum="5FFBB10604C24DC2" modified="2016-06-08" version="1">MSRNSYLIVGGLGFIGSNIVSYIFNVEADSELTVLDKIFQNSNASRISENIWKSDRFRFVNGDVCNEKLVATILNKYKINIIVSSAIIRESDDFDIIEMARNNLLGLTHLVEAVRNYTKIMKFIYISSEEVYGSVTPKVETVLLKPSEPLAASQSSAEAVLNSYAVSHKIPIIIVRLAEIVYDCSSTIQRFFGVLHVQDAVRGVYACIQCSKSPEIYNFGSAYDLTTEQLQTIVWKAKSRESIPTINLAPAMMNSSKAKSDFNWQPEINLIDGIFEVVANYNICSNVTVPSKNMFKYLIYGENNWITHQFIKMLDEKDFLYMKSEKVIESITEDELITEIIQVAPSHIISFISFIHGADEEAIIGLEGSPHKLKQNLQINLYVSWILANICERFGIHLTNINPGCVIHNKNGALSLKLYSTIETMEIHGFNQLKSSYEIVHAFSQRLLRYYPNLLNIYIYLPVSSEIDAENIIIKLMHQSYISNISCPITVLSDCLPILLSHINEKDRGTLNLMNPGTVRLEEIMEMCKNIIDPNLHYEIVPCKNDDNSQRWEFLTRVDEFHPEIQPAVEALKKCIEDIAIAKKNALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q431</accession>
    <name>A0A158Q431_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7891</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the complex I NDUFA10 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q431"/>
    <dbReference type="STRING" id="318479.A0A158Q431"/>
    <dbReference type="WBParaSite" id="DME_0000388601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000388601-mRNA-1"/>
        <property type="gene ID" value="DME_0000388601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17400at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015828">
        <property type="entry name" value="NDUFA10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF15">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000543">
        <property type="entry name" value="NADH_UQ_42KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="14">
        <location>
            <begin position="86"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000388601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49177" checksum="52FFC342621BFE1E" modified="2016-06-08" version="1">MSINGLKIFRNVVVHRFSPLLPKKIFLSSLNSLALMQKRSIVHKNSLKLDEETYPEPWPYKEKGFSFFHAIFDRTQPRFHQNSKLIVVEGNIGSGKTHTAKEIADQLGFYFMPEFKMEHILIDRYGNDLRNFYHLIPQSYRVPDMEMFYKNPGSNMTAVMCNKIFQCRFEQYLNALAHILNTGQGVVLERSPFSDFIFINALRSKNYIGPEYFKHYYYVRKNALAKLFFWPHLVIYLDAPIETCLQNIRNEGNIDKAAVADASFISIIADSYKDCIKEFRPHSKILVYDWTMPGDTDRIIEDIENIDFDFFEWHSGDVFEEWFTTIGEIAWGGWRIYVTSKFEAYMRAFGGIPTHEVNELYVNPRDTGHFLNVIQKEVLKSPYTYGYNPKYGDSIFAGFIVGGGKVLLPEPWLVSIFFKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4N8</accession>
    <name>A0A158Q4N8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9098</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required during maturation of the 40S ribosomal subunit in the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4N8"/>
    <dbReference type="STRING" id="318479.A0A158Q4N8"/>
    <dbReference type="WBParaSite" id="DME_0000529901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000529901-mRNA-1"/>
        <property type="gene ID" value="DME_0000529901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000529901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="633" mass="73173" checksum="39E2B4B24509FD94" modified="2016-06-08" version="1">MRPAGHRTGPFKQVNKKHKTGNSSRFKCRFMFAVVDYNNFNDLLCCIKVSDVVAFLWPLNEIELNEKEEQFMSALLSHGLPSVINFVPGLGTLKTPKDKEVARKNIQNLIFKWSFGEEHIIPCDSDNDGLSALRLISNMKKKPMNIQLQRSYLFVENYRCSPVDKELCDLDVFGYIRGRALNVNDLVHLQGCGDFQLKHIAVCEDPILIDECQIILKPDPLKQQSLQSEIEPDPMNAEQTWPDENDLPRDILPEGTSEYQAAWIFDGGDESENKNRVFNFLLLLIFLASTAKESEPLDLMGTTLDMDDVEKYRRERENAQFPDEIDTPIDKPARIRFQKYRALKSFRTSFWDPMENLPHSYSRIFKFSDYKHSKKVVMKSSNENNESSVSHGSYVMISIAKVPTQSLGESPLVIYGLLPHEQKMSVVNMVLRKHSSCTVPILNKQKLLFYVGYRIYKAQPVFSQHTNGDKFKMERFMPSKGSFITTLIAPITFPPSTVLVFAEDDKDRHLVATGSVLDVNPDRIILKRVVLSGHPFKISQRTAVVRYMFFNREDIEWFKPVELYSRGRRGTIKEAIGTHGYMKCVFDHKLSSMDTVMMNLYKRVFPKWTYQPFLRPYRRVDSIINSEYNQMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Q7</accession>
    <name>A0A158Q4Q7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9182</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Q7"/>
    <dbReference type="STRING" id="318479.A0A158Q4Q7"/>
    <dbReference type="WBParaSite" id="DME_0000538301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000538301-mRNA-1"/>
        <property type="gene ID" value="DME_0000538301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="589"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000538301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="962" mass="107469" checksum="D5C5978BAD37F70B" modified="2016-06-08" version="1">MRFPFCIPFGCGSGIDILEKRQYNLHEVPQDVSRSVHTLEEIYLDGNQIKTIPDMAKKRSKEVLQAVFRCHKLRILSLGQNRIQRLPSMVRSLSALQELTIDDNELTDIPSEIAECNNLRVLDIRLNPLSRFPDNVLKIISLTHLNLFETSLTYLPPDIDLLVNLRSLDVRENQLRTLPASIGSLRNLHQLDIGHNEISFLVGILPFELGSLENLEEFYADNNFLTSLPESFIRCYSLRAIDLSHNEIISLPNELGCLEKLSELIVSENSITTLPNSIGKLKNLTILKAEMNNLTEITPALSSCSSLVELYLSFNNIEANFPLLSLIFISFIIINYFLLFLPSCIGNLHSLNVLYMDRNSLNEIPSTIGCLSKLSILTLRANRIHDLPLEIGRLTNLRVLDICDNCLPYLPFTMTVLFNLRALWLSIDQVTPLIPLETAQDPATRVKVLTCYLLPQGKCQEMLLKHKHVNRSGVVNFKDDIGESEIRESVFQRRGTPHPKSRNRSGISRRHSIDGRFIRHVEDSSQESDKNAESLRRKSVGDNPSCESANKVDLKHKNMRLLQELSKQPLFLEKQKQSANAELSTTVLNIKLKRDPVIGFGLSIARGRGAEPYKEGDSGLFISHIVENSPSASANLQVGDKLILVNGEAVANKFQHVVAEMMQSKDPLELVVQRGCTVESFDSLLDSPVLRHKEISTVEIVAASLRKGFDGSFGITIDSADEPPDSEHIVISSFDNSSAHTNGSIKINGHVLNNKSLEFARSLIYDETITDLFLVLERPSFSFRSKQSLNSMESKICEKSSTSGVDSDEFSVAPTKTNAADFHSNMNQFFHENNLVREAKKIMPLNLQAPAIKRTNRPPVPPKPKNAITFPNTLSKQSKNSEQADSREPNRILNFSDSAEIQLPDDDKVNEDENCGVLNNQKYGINSLAQIKIASSASSSDINSLGAKANSSSLLGKLCFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5F0</accession>
    <name>A0A158Q5F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1664</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5F0"/>
    <dbReference type="STRING" id="318479.A0A158Q5F0"/>
    <dbReference type="WBParaSite" id="DME_0000719301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000719301-mRNA-1"/>
        <property type="gene ID" value="DME_0000719301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991441at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF558">
        <property type="entry name" value="PROTEIN LEV-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041045434" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="8">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="195"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="311"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="489"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="612"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="936"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1224"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1255"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000719301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1348" mass="152061" checksum="96B62ABBFF58F8D9" modified="2016-06-08" version="1">MLLEMLIVLAAFFIKITSTASVCMNVSIAVRPSYCKKACTRDEQCKRNKRCLCDGHCGLSCVNPLTTCHPLIDLQNGYIRTPGDFLFDSNAEYGCDEGYVLVGPSQRRCQANREWSGTKPECRLLKKCGPPPEIPYAQHDGNSYSGQYELNAEVHYSCVAGYHRYGSEGISIAKCLLNRSKAAQWFGPDIRCKERSCPDPGNVVNGSRKGELFYYPHSIEFFCNPGYHLIGASVIRCLNNGHWSDITPRCKPTECNRPPDPLHGKVFGSSLTYQSRITYTCKDGYRLVGQVQRICLAEGIWAGNEPTCEEIRCPALPPLDNGYIEGSDNHFGALVVFRCLEGMSHIGTPYAKCDEDARWSHTLPKCLGGCIVPEINNGKLVGYNASQMVVHGERLQIKCLAKYETAQPNDIVSCYNGSWSYLPTCTPIRCKSWPPRIAHAKVIFMKSVHGAFARYICDAGYRPSGIHNTIKCLFGEWTSESQPFSCEPVLCEHPSKVYGTLEGGNILLEGQMGAYSFAKYIRHVEEGRSIAFQCKKGYILLGTAKATCVNGIWRPRKKPKCVSQTHPIVEGQNTWIRRRRFALSLTVFNQTMENYENSNNYLRMLKRQVRSFECFEIPPMAHRTIIFTKQKPFPSEAMVVCHKGFRFHDGRADGAISCLEGEWSPSIPLCVPKDCHIPMRNNAYFLTMNSNQILQSGEWLKHDSEAHMICMQGYQLVGNDELDCYQGRFNRSIGRCKPKECTLDYDIVTSDNRRRLIHGESGKILCANKSLTVECRFGEVYPRISCNNRDNASEIENSVKCKRPNSDQTFIAYQMANLSGIQTVVDINIHQSVFPNSTILQYICDLSNPLKRANSIQCVNGEWITLLLSCINKKAELLLGWQRKGMCKTPRIDASYRIFNVDADSDLKNSQFAHGTILKIQCAPGFWSESEFDNELRCRQGKWSSTGKIRCYSKNSELFFTCVDNFMQQLRGPSSIICRNGSWSSMPPVCINLDPLNKDENSPPIKFHIMRSPFMISHEGYLFANISSTVRFSCLYPKRKGQPLWETSSIYRKYPQNWNQITLPRFKEVDAYELTISMAQPGDGGFFHCVLPNDEKCTRFKTFMHLRVFYTDPSLYIGTVAQFSCEEGFQIEGTRSSTCLTDGKWSYPKPKCRVCVHDFRDCAALQCPSIAINDAALTATISSHKYGGVARFSCQPNYTIVGKESIQCATNYKWTDTTPSCKVVVCPPPVLPSGSMATSPLKPIYNVQDIVFFECKPGFMLTGSDHMQCQTNGNWTTASIKCTPFCRFPGKPEHGDTTSPERSYYLVGDRVVYYCTSSNYRLDSENVLECLSSSQWSRKVPKCLSIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5M5</accession>
    <name>A0A158Q5M5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1970</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000039">
        <property type="protein sequence ID" value="VDN51997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5M5"/>
    <dbReference type="STRING" id="318479.A0A158Q5M5"/>
    <dbReference type="WBParaSite" id="DME_0000777301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000777301-mRNA-1"/>
        <property type="gene ID" value="DME_0000777301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000620">
        <property type="entry name" value="Mechanosensory protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF170">
        <property type="entry name" value="MECHANOSENSORY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000777301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27255" checksum="F0B5578ABD600FC1" modified="2016-06-08" version="1">MWEKPEKVRGQRECSPFKCVGCKKGISPTDMVYKFKSDIFYHVNCHRCYQCEKVLSPGEQILVDETSKTVACLVHNTSTKSMLLIELDSPLSLSQFSLDSYGYDYADGKYLKRRGPRTTIKQSQLDILNQIFMSTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPFSLDQNVSRFFNSSVSSTTSITIKQLLAFPFDETNDGDEEDGDYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6I3</accession>
    <name>A0A158Q6I3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3690</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000168">
        <property type="protein sequence ID" value="VDN53717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6I3"/>
    <dbReference type="STRING" id="318479.A0A158Q6I3"/>
    <dbReference type="WBParaSite" id="DME_0001018001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018001-mRNA-1"/>
        <property type="gene ID" value="DME_0001018001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13223">
        <property type="entry name" value="PH-GRAM_MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="10">
        <location>
            <begin position="121"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="303"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="334"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="558" mass="65022" checksum="908B799D01379547" modified="2016-06-08" version="1">ANIGYISPIGKIYGRVIVTNYRLRFEAKDSPIRQNKCCQFDVPLGCISRVEKVGYSTVSRGEDSYGLEITCKDMRNIRFTHQQTNHSRRPLYENLQRFAFPASNKMNFFALSYKPEWTFDGWTVYDPLKEFHRLNIPNESWRISRINDRYEFADTYPALLAIPAAAIAEGEEFLHKVAEFRSKQRIPVLSWLNPLTQAAITRSSQPMVGVTSRKSVEDEKYLQMIIEANAHAHQLLIFDARPVVNAKVNKAKGGGFEDSYSNCRLIFLDIQNIHVVRESMRKLKDCSFVRLDEKNWLKNLDETKWLSHIQMILEGATQIAAEVEDNSASVLVHCSDGWDRTSQLTSLAMIELDPYYRTISGFGVLIEKEWCAFGHKFAHRVGHGDDKYSDSERSPIFVQFIDCVWQIQDQFPFAFEFNSSLLITILDELYSCRFGTFLCNNEKQRFREQHLKQCTISLWSYVDANKRSFLNPFYNHYPRHIDVLRPNTKMARIKPWRDYYFRYCPKIIAQDLFSNYLNRLLKVFDFNAIVNEKILQRIESLGAVIRAREQSINKTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6I6</accession>
    <name>A0A158Q6I6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3710</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000171">
        <property type="protein sequence ID" value="VDN53737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6I6"/>
    <dbReference type="STRING" id="318479.A0A158Q6I6"/>
    <dbReference type="WBParaSite" id="DME_0001020001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001020001-mRNA-1"/>
        <property type="gene ID" value="DME_0001020001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001020001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="766" mass="87225" checksum="FC1F5A816BBCDCF1" modified="2016-06-08" version="1">MASVNCGIRFTITGNYLCTVYFVLFKHSLFAALVEGRGNARGEIGLACMDATCSYLFLYQFLDSASYVRLRMQLHILEPIEIIIPEVTCERSANMNVIIELIRSNFPHIEITMVNRRYFKYYCMAATAALIKYVEKIQDIFFAQGTLNIVYQSTEKSCLIDVNTMHSIEIIERMCEKYKVVGHSLYSILNECQTGGGIRMLRSNLLQPSADLEAINARLDAIEELITNQPKRDRLRLIIGNAFDIQHLITLCCYLEKNNETVRTAEQRISQILSLKQTLQLIMPLKQALDSSSCRLFQVCFKQLNDKRLMQIMDLLDEALEPSMIIAEKSALAMRYRRCYALRAGQDNMIDLARKGYEELIRDMQEKSEEEKQQLPDARLVYTTHRGFHFSMTCFDPLSIIKLPSHFIQIVRHQASISFTTQSFIRYNDRIQNAVNEIMIRSNALIIRPLIPSLYHLIEVISLVDFITCLALYAVKVATVRPIFSAANSMVIKQGRHPLLDFSRGNVVANDAYLSAESYMAVITGPNMAGKSTYLKQICLLQVLAQTGSFVPAEFAAFPLITRIFSCLDHNDNLIANLSSFALEMSEMVTILTSANSSSLIIIDELARSTAIEEGVSICYAICEELLKLKVVIIHIHQNYHFSVNFKTVMHDGGTPLNALEITHRLCKGSYKKTLYDLLEGLNIAELSTFPREVLDDARSLAEILCAHKERPKKYDAEIKKKLHILRIINKLRSVLPILQKVEIEAAKNYLLNLRKQFYDNVNTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PW19</accession>
    <name>A0A3P7PW19_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000190">
        <property type="protein sequence ID" value="VDN53838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PW19"/>
    <dbReference type="STRING" id="318479.A0A3P7PW19"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="56"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="200" mass="23030" checksum="38B424A89C5D228B" modified="2019-02-13" version="1">MVKKSLCPKIFSNPIVFYWRNPQFESVLLNLQHLWQANPDCALIYSHKIMKLFSRFRTISREEVAKHNTLHSLWMIYEGNVLDLTKFVPNHPGGERVKYSKKVFNIVSRDGAVVQSHIISAQHLPLLENAGTDGTLRFKNVLHSKDAIKMTRNYIIGTLHGKNSYFCTLITGSLLAIATAIIFFRFVLKLTTQMKSFIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYI5</accession>
    <name>A0A3P7PYI5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS4751</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYI5"/>
    <dbReference type="STRING" id="318479.A0A3P7PYI5"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000049">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000229">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0117">Actin capping</keyword>
    <keyword evidence="8 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="106"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="2054"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2163"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="928"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1253"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2163"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2183"/>
            <end position="2194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN54778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="2194" mass="255536" checksum="0F303BA5EDC11754" modified="2019-02-13" version="1">MLRVNCKIHDLYMDMRDGKMLIRLLEVLSGERLPKPTRGKMRIHCLENVDKGLQFLRDQHVHLENLGSHDVVDGNPRLTLGLIWTIILRFQIQDITFEDADNQETRSAKEALLLWCQMKTAGYPNVNVRNFTTSWRDGLAFNALIHKHRPDLIEYEKLQKSNALFNLGNAFDTAEQQLGLTKFLDPEDVNVDVPDEKSIITYVVTYYHYFNKMKQETIQGKRIGKVVNELMENEKLVGEYERLSSDLLEWIRQTIETLNDRRFVNSLSGVQKQLAEFNSYRTKEKPPKFNEKGDLEILLFTIQSRMRANNQRPYLPREGKLIADINRAWESLERAEHERELALKEEIIRQEKLEQLAARFDRKAGMRETWLSENQRLVSQDNFGTDLASVEAATKKHEAIETDIYAYEERVQAVVAVADELEAENYHDINRINEGKENVLRLWNYLLELLLARRVRLELSMAVQRIFHDMVHVLDWCDEIKARLLSEDLGQHLEGVEDLLQKHALLESDINIIGDRVRAVNGQAEKFTAPSGPDGSGYKPVEPSLVEERMQILVDRYAELKKLSEERKRRLEDNLRLYQFWWDVAELEQNLKESEQVLTSPDTGRDMVSVSLLLAKHKNAEQYLDMAGRRLDDLDKEGEKLEAENIPGSEAIKERLATVRDYFNKLKELADERHKRLAGGVNYYQFFNDADDVDAYLVDTLRLVGSEDVGKDEGTVQLLIRKHDDVSEDLLKFDENIKQLHLQAEMLPADARTHPDVLERLDTTLRRKAQLEELSRLRKQRLLDALSLYKLFSDADSIEAWIDEKGKLLATLVPGGDLEEVEIMKHRFETLETDMNNQAAKVATVNELARQLLHVDHPNSEEILQRQNKLNARWAQLRDMVDQKRTELDQAHRLETFRIDCQETVSWIEDKTRVLEDADDLTNDLTGVMKLQRRLSMMERDLGAIQAKLDSLQTEAAEIEKEKPSHAAIIRDDIRRIQQVWDVLNRKVREHEAKLDEAGDLQRFLRDLDHFQAWLTATQRQVASEDEPQSLADAEQLLNQHAAIREEIDGYAEDYVKMRAMGDRVTQDQTDPQYMFLRQRLAGLEEGWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEVILSQQENYLTKEEAPSSLEQAENMLKKHQDFLTTMDANDEKIKAVVLFGDQLCTDGHYAADKVHKKARNIEERREANREKAAAVFAKLKDALALQQFLSDCEELREWIEEKMIRAQDETYRDAKTITSKFLRHQAFQSELQSNRERLDQLRHAAVRLAEEKPEFVGTIDPQIKDLSVQWEQLEKTTVEKGQKLFDANRQQLYVQSISDMKEWAEQLQQQMLSEDTGQDLTTVNVAMQKQQLIESEMVKRAAQMDSLQQMEPQLEEMHPDEVEAIKAHRLAVQEQLQRLQAPLDDRRRQLERKKKAYQFMRDVEDEKLWCAERMPLAHARQIGESLFDCNRLQKKLQSLRNEIDNHEPWIEKICANGRELIDEGYENSAAFELKINELLNTWKELKDAVDARKEHLSESEKAHQFLYDCNEAEAWMSEQELYMMQDERGKDEFSTQNQIKNHERLQQDINQYADTIRNLASQAQKFVDEKSPLHEQISVRQAQIEKLYAGLQDLCRERRKRLDETLQLYELHREIDDLLQWIADKEVVAGSQEAGQDYEHVQMLIERFQQFARDTETIGSDRVSSANDACDQLISLGHTDAPTIALWKDSLNEAWENLLELMDTRMQLLEASRMLHKFFHDCRDCLSRILEKNHAIPEELGRDSSSVGVLKRKHLTFLKDIEAIGQQVAQIERDAVELRDAYAGDKAIEIGAREAEVTKAWRQLRAICDSRSQRLSDTSDLFRFMNMVRDLLLWMDEVKREMNTQERPKDVSGVELLMNNHQSLKAEIDAREENFNACISLGRDLLNRKHYASSEIEKQLIKLTTERAEMMRRWEDRWEYLQLILEVYQFARDAAVAESWLMAQEPYLISKEYGRNLEETIKLIKKHEAFEKSAAAQEERFLALENVCYFAERSRLGSSETSGWRLSLSRSVRFDAQDLRGVDIGDAFEGVLIRKHTYESLYRKASSRSWEKVYAVLRGSQLSFFKDLKHKEENVFFHGEEPISLENCTVAVAANYTKKKNVLSLKLSAGGEFLLQAASEEDLERWLRRLQIATGQSQEEQSRSQTLPAEGSSKAKRGFFSRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYN9</accession>
    <name>A0A3P7PYN9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYN9"/>
    <dbReference type="STRING" id="318479.A0A3P7PYN9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="83" mass="9955" checksum="43139B2DACE7F673" modified="2019-02-13" version="1">MTELEKEYYTSKYLNRTRRAEIASILNLNETQVKIWFQNRRMKEKKRQKEQAFLARGNRPHQINWSDSPSSISNIDDSPKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q319</accession>
    <name>A0A3P7Q319_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q319"/>
    <dbReference type="STRING" id="318479.A0A3P7Q319"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="225" mass="25061" checksum="D92611B19E344E5A" modified="2019-02-13" version="1">MHGLGDTGHGWSTVCATDLRLSHVKYICPHAPSRPVTLNLGMQMPAWFDVFGLTPDAEEDEDGINESVKIVHSMIDEEIRNGIPAERIIIAGFSMGGALALYAGLTYDKPLAGIVGLSSFLVQRDKIPGIFFTVAFAHKNEIIQNTHDFQNHTANKNAHILMGHGDADFVVPRTFGEMTAQFIQTFDPNIHIKIYPGMAHSSCPEVSLLYILKKFIFYWLIHFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QJE2</accession>
    <name>A0A3P7QJE2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS4870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QJE2"/>
    <dbReference type="STRING" id="318479.A0A3P7QJE2"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000011">
        <property type="entry name" value="Prolyl alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="352"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN54897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="495" mass="57415" checksum="47FDB2C77A989AA0" modified="2019-02-13" version="1">MIKDYQTKNKQILAEGANSLRNPIKAFLLIKHLVIDWKIIENLMMQNVAKVFIRRIAEERIKQKIKYPTEEDLTGAATAIFRLQDVYKLNTKDLSNGKIFDVGSNQNLSARDCFLIGRAAYRAKDYYHALLWMQEAYDKVQKESEPSFEDLQDIMEKLSFALFKQGNVKRALLLIEQLKEIAPNHKRTAKKIKLYEEALKKEGFKPNEFRENIPPMENRRFEDETRYRTTHIYEALCRNEIPIGDEEISKLYCYYKQDHPYLLLAPFKVEIVRFDPLAVIFHDVISNEEISIIQEVSHSRLERAQVVSPATRRREPASFRISKNVWLENNEHEIVERLNRRIHLMTNLDLKFAEDLQIANYGIGGYYDVHYDFFMKDSPLLESLPQGNRIATVLFYMSQPEIGGATAFIPIKTTVLPSKNGALFWYNLVRSGEGDHRTHHAACPVLVGIKWIANKWIHEAGQEFLRPCGLKETDQEAFVGDLGGPVPKDHSNIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0J1</accession>
    <name>A0A0N4U0J1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hflx-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4434</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0J1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0J1"/>
    <dbReference type="WBParaSite" id="DME_0000007401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000007401-mRNA-1"/>
        <property type="gene ID" value="DME_0000007401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10268034at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000886">
        <property type="entry name" value="Putative GTP-binding protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="5">
        <location>
            <begin position="228"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000007401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53854" checksum="1C84A1B92F6DB6B4" modified="2015-12-09" version="1">MARIVFRRFCTLKVDKICLQQEFNIVKQCFGAQGFFGATHRVMVVHPKVRWGKHSTSLLTSPELQLNEAISLVNTLPYLRVTSSSIVGADYSTKKKNMWAKGRIEKLKEQLRNDRVTAIMINVDVLSPEQQRHFYSVFGIPIFDRFNVVLNIFKHYAKTKEAILQIKLAEIPYIRYFIFHQFHQTDNFYPSDHCEMLRLREHSLRKKLKAIMEKNNNLTKGQENKKVATIAVVGYTNVGKSSFIKLLTGKALFVEDRLFATLDSSTHFCRLPSGTPIYLTDTIGFISNLPINLFASFQATLSHVINADLLIHIEDVSHPGRFAQRESVLKTLSNLKIRQSLLDSMIIVGNKVDKVSSIIDKESNMHYISCLTGAGIPELISTIDQNIISIKRKVLRHLKLRPGSNAWYYLYKNSFLFGKSVPSNDNNFLHCKTFMDDEEFRLFEIKFSLSKHTKNDSKSPLSSFGISNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Q6</accession>
    <name>A0A0N4U0Q6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4503</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Q6"/>
    <dbReference type="WBParaSite" id="DME_0000014301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000014301-mRNA-1"/>
        <property type="gene ID" value="DME_0000014301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000014301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14840" checksum="01B469EA46DF2654" modified="2015-12-09" version="1">MFEQDVFRYLETIEIGDPIDSVDDEEDCGQFLKSVRKYEDRYAGLERTKTLIGIKFWISLWKNANRLKDQYDQGFKEQLENIIQLATPEVITYLIYYAAHLPIITPDKLYATLRVVFNALASSKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0V7</accession>
    <name>A0A0N4U0V7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4563</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0V7"/>
    <dbReference type="WBParaSite" id="DME_0000020301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000020301-mRNA-1"/>
        <property type="gene ID" value="DME_0000020301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000020301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="23679" checksum="F6B43A14FD123CE8" modified="2015-12-09" version="1">MINFFFSYRYLDVEHIHEGDSGGEGIEAQGSKHGREGAGGENRGGSAGNWGKQQGLNVGGCCGGKGGSEGKQQGLSNGCCNCSGGSTGNGGKEGNVGNEGKQQGLASGKGGKGGNVGKEGKQQGLASGKGGKGGNVGNEGKQQGLAGGEHEHGGCACAAVLKKHSYSHKALMLTIRFTVCRILTNNELRSRKTITMAACQPGSSAFANELELLKSTRIDFYIIKRLHFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Z2</accession>
    <name>A0A0N4U0Z2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4600</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 11"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Z2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0Z2"/>
    <dbReference type="WBParaSite" id="DME_0000024001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000024001-mRNA-1"/>
        <property type="gene ID" value="DME_0000024001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000024001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25586" checksum="BD18C58FA5BF1335" modified="2015-12-09" version="1">MTPSLKWIPLESNPDVISNLMLKFGVEKDVICVDVYGFDKELLDMLPKPCYALILCFPECQKVKEMMAAVYDDHVKSNGSIPENVFFMKQKISNACGTFALIHALANNKNKIDLGNGPFKKWLEKADRLEADLRSDSLQENAELAEAHEVCAVSGETNSEVEEVEHHFISYVNCDGILYEMDSSRDFPRACGPTNEENFLQDAGKVCKELMLMMDSISFSALAIVRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1L7</accession>
    <name>A0A0N4U1L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase_M3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4868</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1L7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1L7"/>
    <dbReference type="WBParaSite" id="DME_0000050801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000050801-mRNA-1"/>
        <property type="gene ID" value="DME_0000050801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="90"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000050801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32569" checksum="11C662A835835A32" modified="2015-12-09" version="1">MSLELEKSNLTDIDRRTILLFLADFENSGVHLHDSKKQEFVELSTEIFDAGSKFVSEAGKPVQVNQFDRKKYGVDRLLTNPYPFTICEATRRWSYSTYYRHNEKQESSLRRLITARHRLANLTGYKTFADRAQEFSILGSYENAHNFLTEIIKCCRPSADRELTVLLDVLSQCDSQSEKLGEWDLQYLSAVYRQKAYGNIGAISRHLSFKNILFGFELVTKKLYGVRFSLETAEAGEIWPGNVHKLVVLDSSNSHIGTIYLDIEKRATKVTGDCHFTVRCSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2C7</accession>
    <name>A0A0N4U2C7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-phosphatidylinositol-5-phosphate 4-kinase</fullName>
            <ecNumber evidence="11">2.7.1.149</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5182</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12280"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.149"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:12281"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.149" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2C7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2C7"/>
    <dbReference type="WBParaSite" id="DME_0000082201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000082201-mRNA-1"/>
        <property type="gene ID" value="DME_0000082201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17305">
        <property type="entry name" value="PIPKc_PIP5KII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 5-phosphate 4-kinase type-2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="14">
        <location>
            <begin position="26"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000082201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45836" checksum="53CE3A0A6A7156EE" modified="2015-12-09" version="1">MSKKTPRSGKRGKRKVLVPKWKLFRAKEPLLSVFMWGVNHCIGELMHVPPPGLLMPDDFKASVKIKVDNHGFNKDNMPSHFKVKDYCPNVFRNLREHFGVDQNEYLRSLTYSEPEPELDQADKSGSRLFVSYDKKFVIKTMDSEAVAELHSIMRSYHEYVVEKHGKTLLPQYLGLFRITVDGSETYLIIMRNIFGRKYNVHRKYDLKGSTVQRQASEKEKAKDLPTLKDNDFLEDNYKLLLPENAREKLVNMLSTDTEFLARLHLMDYSLLVGIHDIDRAEAEAEAANQSVPEQSEGELSDDLVPTPPDSPLPSTGAFAPMLPGRPDLDDEFFAIASNPTSGKRLIYFIGLVDILTYYGVKKRTASAAKAVKYGSEAENISTVKPDQYARRLVEFVTRAVIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U326</accession>
    <name>A0A0N4U326_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CFEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5474</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U326"/>
    <dbReference type="STRING" id="318479.A0A0N4U326"/>
    <dbReference type="WBParaSite" id="DME_0000111401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000111401-mRNA-1"/>
        <property type="gene ID" value="DME_0000111401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6134775at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000111401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20451" checksum="BDCFAE55B9D8B39F" modified="2015-12-09" version="1">EQIIATEAAGSWPTPFVFPEVPCAAFTDEVCYQQLKQVGMTALNKCCTKGIYLTDICMAGHCSNSTIQICCAQKFLQARYRCCEDKNQEKADASDSFSRCCYENFVEDRDNCCPSDVAKIHWLSLYDICLPDVRIDLSEVQLTASTSDTKMISVDLNIDRSWDHKCRYGGKALQFPYLPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U347</accession>
    <name>A0A0N4U347_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5499</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U347"/>
    <dbReference type="STRING" id="318479.A0A0N4U347"/>
    <dbReference type="WBParaSite" id="DME_0000113901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000113901-mRNA-1"/>
        <property type="gene ID" value="DME_0000113901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000113901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10270" checksum="120AAEB578F74869" modified="2015-12-09" version="1">MGTRVYVGRLPPRAYEKDLERFFRGYGRITEILLKNGYAFVEFADSRDAEDAIYERNVEAMNLKESGSFNFLIFYYKFNFQTKDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U356</accession>
    <name>A0A0N4U356_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5509</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U356"/>
    <dbReference type="STRING" id="318479.A0A0N4U356"/>
    <dbReference type="WBParaSite" id="DME_0000114901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000114901-mRNA-1"/>
        <property type="gene ID" value="DME_0000114901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="138"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000114901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37999" checksum="F57685E738E7554E" modified="2015-12-09" version="1">MEDEEERRSMEKTDMQGVEIFLKPFLGLAFHPLNHAKILQQLGFEPFPLSVGKMYFIGRETYFLPNTLEYARNIIKLYGWSTVFTGADAAVCSQLTNCLVSMNVSAYIDKHHSDLGGIFDDEDLKKDEKELSDWFSARRHLRSAIRETVVRSAAIVAARPFVVIMVRQIAQLIGGETKYGNVFSSIFVIGAEEGPAGFFSGLIPQLIAEIASIWGTHILIYGIERSLLITQRHFPEDEKEQQLLKSTGNVVRTVSPFIINSLCYPYNLVSTVMAVAGSGLIVSMLPYSPGFGSWIDAHSYMKLQGALKRGAKFFFREHTGVVHVGRNKEIYADFKHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3G9</accession>
    <name>A0A0N4U3G9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5634</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3G9"/>
    <dbReference type="STRING" id="318479.A0A0N4U3G9"/>
    <dbReference type="WBParaSite" id="DME_0000127401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000127401-mRNA-1"/>
        <property type="gene ID" value="DME_0000127401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000127401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14571" checksum="559DB6C16A44F63E" modified="2015-12-09" version="1">MFLQNFAELSINYEQNAHKLEECEKALEELGCNLSESKLKIIEMQEELLPLSDAQWENDANVENCKRCNIQFSVSKRRHHCRKCGSIFCNSCSSARLKLPSNAKPVRVCLPCYNYLQNRQNCVPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3K5</accession>
    <name>A0A0N4U3K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5672</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3K5"/>
    <dbReference type="STRING" id="318479.A0A0N4U3K5"/>
    <dbReference type="WBParaSite" id="DME_0000131201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000131201-mRNA-1"/>
        <property type="gene ID" value="DME_0000131201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000131201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44803" checksum="890577A34B1769CD" modified="2015-12-09" version="1">MGGKETNATFIHHLSTTHIPDTRGLEQLGAQGTLLQDLEERIKRERVRYHAMWEHLTTKRSPDTINNQTISSTTGTISSTNSIASPVIISNDNRNDPFVEQRPSPASLSTSMNLTDDNRLSSSSSSHHHHHHHHQQQQSQPQQTQQPQQQQQQSATSSSRRRICDKSIIPISSDITRNREFYRNNDVRPPYTYASLIREAIMESKDCQLTLNEIYQWFTDTFAFFRRNAATWKNAVRHNLSLHKCFTRVEQNVKGAVWTVDDTEFYRRRQQRGTITRSTPTTPKAADNSLNILASAVASSLTNVDLRAATSSPVSEQHQQFDDDEQHLEEIKEEKREHEEEEEEIIKNDEKRTITATVTAQEASTVDSQGLLKMFIKQEEESSPKLVVDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3L3</accession>
    <name>A0A0N4U3L3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5681</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3L3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3L3"/>
    <dbReference type="WBParaSite" id="DME_0000132101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000132101-mRNA-1"/>
        <property type="gene ID" value="DME_0000132101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950413at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000132101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11105" checksum="B74AD6CFFF4C7AF9" modified="2015-12-09" version="1">MINIPITIHKNSLLLINKTRNIWKTPLLNKNVVGKYRSTNDNSQLLTYEMAMRPQFVGVRKAWLTWHTQNLENFKLRQGQTIGGARNGMWSYMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3M5</accession>
    <name>A0A0N4U3M5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5694</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3M5"/>
    <dbReference type="STRING" id="318479.A0A0N4U3M5"/>
    <dbReference type="WBParaSite" id="DME_0000133401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000133401-mRNA-1"/>
        <property type="gene ID" value="DME_0000133401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07211">
        <property type="entry name" value="Pat_PNPLA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045217">
        <property type="entry name" value="PNPLA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="158"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000133401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50872" checksum="6FED30BE01D88E56" modified="2016-06-08" version="2">MSSLWKNDKKAPSPVESPSKSNKHVITISRSEIAERTRGLVSSFLIAQSQSSLKLRVLELCNHFAEYPSSRILAVEDKRFMNTLHRYLRKLDDESVKGCIRQCLSVMGYVGSPKGCGVRILAIDGGGTRGMMGLEVLQSLEESLGGLKICEVFDHIVGVSTGAIIAALLTVKKLSISECKDIYYNTSRELFNQGRISGVSGLLISHSYYDTKKWIEMLKKLTGEETLLDTCQCGKTPKLGLVSCIVNAPGLIPYVFRNYEHPPGCDSHIRGGCKHPIWQALQASAAAPGYFKEVAIGSVLHQDGGVLVNNPTGLAVHEARMLWPDEKLQCVISVGNGRTVTELEATDVRMSTSIQDKLLRIVDSATDTELVHLSMNDLLPRNSYFRFNPYMSFPYSLDEIDPTKLAQMCRDAQLYIRRNKAKFAAAAEILLAPPSTTQILHRKFQNFLYHSGYFTQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3R3</accession>
    <name>A0A0N4U3R3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5734</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3R3"/>
    <dbReference type="WBParaSite" id="DME_0000137401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000137401-mRNA-1"/>
        <property type="gene ID" value="DME_0000137401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6142715at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000137401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8047" checksum="3821B36073578B71" modified="2015-12-09" version="1">MSEKARSALIEWEPVNDHLFCAYFKRKLYITSVIIVYAPALCADHDKFCAELQLPTSLPRCNMVITEKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3T1</accession>
    <name>A0A0N4U3T1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5753</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3T1"/>
    <dbReference type="STRING" id="318479.A0A0N4U3T1"/>
    <dbReference type="WBParaSite" id="DME_0000139301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000139301-mRNA-1"/>
        <property type="gene ID" value="DME_0000139301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863642at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000139301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="79332" checksum="2B4B4C9D986886BE" modified="2015-12-09" version="1">MMLNDEKCVKAAASKQPTDLLSDYAARSSCCLIPNNSFHLLFLLFPFQKKTFRGKPEWQKTDDCLCARNSPVCCLHNSTKEYCSQDKDARESGINEDFVAEKGRCIFQRRTSLFMFSDSSSRICGLNQQHVNKAIESMHKFAALILRFFTAICTFLKDGIYWLMALIGNDMQRSVNQTEDKNLDDFVQKYFDNEWTMKDEAVKQNQEEQEKIDIIQFSTTGAPLSKSNESEMHERKEKFLKQNEERGTQFYTTKRRISENCKRDEDPTASLYPIPLSPPPPPLAPIWITSPQVGTMQKVPKGAVPLFPPDVLAGTHAYLKQKKEKSREKVKSPNSEIVDGDWTVSNARMIFQDLVRPHSSFLKEYDDRDNVFGEEEDVHWIPPKKSVVSKISKPNDPNAQFIFRASKPQMAEIHSRLSENNFIMGQSVFSPIKEAEELRTSINRKATATPESHLGSRIATPCDDYTYNRQTPIERYHYDYYTPIGTEQYLAPRSHSHSRLASLISRFDNSQHISRTNGDRINVLKQRSRTVEPRSNLAMEMTRHWPPKNNTAGVEIVKNNWNSIPTEIISCRLSLIIFFLQYFFVHTTSFLPDKANKCKVKLISAQGFADPLRTAERSVTNKWTTKDDKGRVLNEYSTRQWIGENDGLRRRGDGTGESWRNVVEVKPDGKTNFFENRKYYTKNYLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3U6</accession>
    <name>A0A0N4U3U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5773</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3U6"/>
    <dbReference type="WBParaSite" id="DME_0000141301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000141301-mRNA-1"/>
        <property type="gene ID" value="DME_0000141301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874906at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF15">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000141301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17440" checksum="7751C598E18526F1" modified="2015-12-09" version="1">MRIIPKNHCSIGALLAITGCLCNLLLLIIFIIGRRRQNISLYYKLLAFLDLLICFTYIWMFFLPKFSEILRIETLYILVWQANIFVYTVARMTQCAIPYIIIAQTAERFMHLKRGKTISRIIGLIFLLFKTAILFLYFYYLCVVVITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5A0</accession>
    <name>A0A0N4U5A0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="4 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6373</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4 11"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5A0"/>
    <dbReference type="STRING" id="318479.A0A0N4U5A0"/>
    <dbReference type="WBParaSite" id="DME_0000201301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000201301-mRNA-1"/>
        <property type="gene ID" value="DME_0000201301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000018">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="221"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000201301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="61029" checksum="F854551EA4CEA026" modified="2015-12-09" version="1">MDQKDCLHRKHSISSPLHPDLITYLKESMGDVLTDPYVFVIFGASGDLAKKKIYPTLWWLFRDSLLPTNISIIGFARSDLSVDQLRKEFEKYCKLHEGESDKFNMFIRRCTYIRGRYDASADFVRLQNFIDGIQEKCGDAPVNRLYYLALPPSIFQEVTTRIKKNCMDRGDSWTRIIIEKPFGHDAESSANLSKHLAKMFTEDQIYRIDHYLGKEMVQNLMVLRFGNRIFNPSWNRDNISSIMISFKEDFGTEGRAGYFDKSGIIRDVMQNHLIQILTLVAMEKPASLNAEDIRDEKVKVLKAIKPIELSEVVLGQYVRDPKAKSGEACYGYFDDPAVPKDSVTPTYALAALKIDNERWDGVPFFLRCGKALNEKKAEVRIQYKAVSGDIYSPGELKRTELVMRVQPDEAVYIKLMTKRPGMGFGVEETELDLSYSHRYKNIRLPDAYERLLLEVIMGSQINFVRTDELDYSWRIFTPLLQKIERERIKPIEYEFGSRGPKEADELMRKHGFVFSGTYKWKGSRCDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5G0</accession>
    <name>A0A0N4U5G0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6442</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5G0"/>
    <dbReference type="WBParaSite" id="DME_0000208201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000208201-mRNA-1"/>
        <property type="gene ID" value="DME_0000208201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917100at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000208201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36804" checksum="A05D5ED4D1119683" modified="2015-12-09" version="1">MAAPIPYRTVKNHQSIGSFPPATYYRDTYGFQPEHSQAHPQIKRTTGSITTIGSDTDTATTKSTVRTTINIQNLMLESSTSKGTANTPSFHKGKKLKKLKFEVEQMITNQLLLFNARTLLALSLIAFASAIQLLIFATICIFYDGCPYYLAILSSIIFMYNALFIIYFIRYRSTKIFLVLCTIQTTICFICSLGLFVWTAYLIYGEDRNIRKQGWYFYEENLLKINRLISNTRIAMYSLHMILTPIQGLCCAGILKILFENLYSLEKNKISKGYFFTEPTIGHQTVLVPIELKRVENLDESDVENASIGVQTSGNQSSKETNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5X9</accession>
    <name>A0A0N4U5X9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAU2 chromatid cohesion factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cohesin loading complex subunit SCC4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6646</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5X9"/>
    <dbReference type="STRING" id="318479.A0A0N4U5X9"/>
    <dbReference type="WBParaSite" id="DME_0000228601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000228601-mRNA-1"/>
        <property type="gene ID" value="DME_0000228601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000228601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63484" checksum="B32010AB16A56EAF" modified="2015-12-09" version="1">MNVPYEKIQENQIIDQYAISLLDIAEYFRTSNPPKYKMAIKCVKACFKTPISQEMNACASFELGKLYFYYTRNIDLAKFYLEQAYRCMKELGTVLTKNRIETACLLSEVYMQLKMYEPVKQILKEEVPYSREFHQFYAWLLFLLAEAYGTTGDWYNANEIISTGITIFEQLENAPLECFFRLSQALVKTLLKNTKTCLRQLQSLVQTMKSTYDENTSQWPLFDWMGKETLTALTYLLTVIQSIHNCQMPRAYKYHTIALRHINDMRRLMVRSDWPVIRRRALEALAAFEIILFENIATAQLMVAKPYEAISVINVMVEKMRLNADLFNCFEPQLHTLLGIYCWSVRLPENAERQFQAALRTAKDTDTWIVINLSLAIVYLLTCKGSDFYGLFERITPGKLQSSSPLLKASAHFVHALHSYLQSRLQEAKSHLTDSVTIVRDEGAPRIQALATLLSAKLVSLEAPDMLLAANNWAVKSADNSLILWSNHLIYELQLQFGHTEQAQFVKQKVDQVQQRLNANIQQALLAPAHSLIQNGSTPVNDENELIIKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6R4</accession>
    <name>A0A0N4U6R4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6R4"/>
    <dbReference type="WBParaSite" id="DME_0000263001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000263001-mRNA-1"/>
        <property type="gene ID" value="DME_0000263001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771022at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000263001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19078" checksum="803EDFAEE489FF8F" modified="2015-12-09" version="1">MAQEPVAPWSRWDPPGYQPLTSYAPDFFQNDNFDDSGLSQTRFVQGTLLEQRPSAISGFVECIYGLPNSTERIIEQCLNEVGCCATGCCESRRWIDQYRWAVALIVIFCIFVVIAVVVWFVIWLINRSKDKQLRQNLREMSSANSQVSLSGVKDAGYYPYVGGPRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6W2</accession>
    <name>A0A0N4U6W2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Trehalase</fullName>
            <ecNumber evidence="2 6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7051</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 6"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6W2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6W2"/>
    <dbReference type="WBParaSite" id="DME_0000269101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000269101-mRNA-1"/>
        <property type="gene ID" value="DME_0000269101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF3">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000269101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65932" checksum="1FBDE376170CED3F" modified="2015-12-09" version="1">MIWNGIMKIINDVGIVKNYSLPRCSESVCVGPLSDIYCNGKLIYITWLFGLQSTCPGEMLLRSPKEVLGDFYSLPNPIKRENFEKFCNRNFAKFPYLSSAELSDWTQEPYNIRLLNDTHLRNFTLKLNAIWKKLGRQFNPEVREKIHLFPVFPVPNPFIVPGGFFNIYFYWDSYWIIKGLLFSNMTLTSRNILNNFATVITHFNFIPNSGNIGLSRRTQPPLFVQMVADFYDATKNKTFLAEIMPFIETELSWWQQNRSISVDLPTGERYSLFRYNSISNCPRPENYLVDLDNGLNGTGDPEFIWSSIASACESGLDFSSRWFEYDGPHAGTKFSIRTNTVIPVDLNVFMAWNYFTVGNFFKILGKENKTKKYDILGKELKNAIQAVMWNDEDGIWYDYDLVKRQHRKRFYPSDVFPLLLGEVSDEIGSKILSYLESVQVLDFRGGIPSSLDKESEQQWDYPNGWAPTIHLFVESLRVSGHKQLQKLAKDIADKFIHTVYNGLMNTSQSLPSACWEKYDVRYEDGRPGNGGEYIVQQGFGWTNGAVLDMIRRFYILQSGHFDLDSKGYSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U704</accession>
    <name>A0A0N4U704_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U704"/>
    <dbReference type="WBParaSite" id="DME_0000274001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000274001-mRNA-1"/>
        <property type="gene ID" value="DME_0000274001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845603at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039151" evidence="1">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000274001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="36261" checksum="4026AC701A528F80" modified="2015-12-09" version="1">MALILPLQLLDSVVRCYCCSNYDNSRTRIIEILINRASIFDVIRWRRVSRAFRAAAQKRLDRIRIIEVRLYSNLRQLRESKQRRCTLTPYINYNCEWHPIYDLMVVELDQSHLAVTIDPKATWKEIKALIHLLMLFKQNIEHLYIDSPIIEILVAEVNSQQIKYITSIFHQSQMGKSDEYRKNSQSLIPINKLFMPEEPFFPSLKSLFIISQCDEVEHLSRLLAYSVSVDLLYHVKQMDLLCLKICVGKEWSTGKNPGMFRHLMRFREWTEANSLGERYFQQFGSHLQKRERFLIRNQIKKGCSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D9</accession>
    <name>A0A0N4U7D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS127</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7D9"/>
    <dbReference type="STRING" id="318479.A0A0N4U7D9"/>
    <dbReference type="WBParaSite" id="DME_0000289801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000289801-mRNA-1"/>
        <property type="gene ID" value="DME_0000289801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876908at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000289801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32481" checksum="39A13A2BC8D6BA42" modified="2015-12-09" version="1">MVALWNDDARFVLIEEIRKRHEIWESRKERYGSTERKKELYLEIAETINSCCVAPSQIFTEDDVRTQWKNLKDTFKRKMKKRQADIEAGVEDTEPTWRFWSKMLFINQPVEPSPLGINGNSNDASNSLESLLSSLVEKQITDESNSFDGAGLNTSKLPLTSMNCDSFQYNTKEMHPNHQVISSDDTEANSQHYSIQSTISLNQSPRKAQKRRTTDFDEDFAKNNIEDEFTWFGRIVSVTLRRFSEIDKILALNVKKQIFDLIYDYEVKQLLQQRNMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8K3</accession>
    <name>A0A0N4U8K3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS246</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8K3"/>
    <dbReference type="WBParaSite" id="DME_0000338001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000338001-mRNA-1"/>
        <property type="gene ID" value="DME_0000338001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269610at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000338001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13746" checksum="54E817AEB6C1D9B5" modified="2015-12-09" version="1">MKAFTDLLRWTLDFGLVESILSITGLLRLFIIIHLGIPTIKQWESMDADYSIHRHEFSWIMPSYNQPDLWLAEFIRYDPKRRISAKDALVHEYFNDLNKSSLPTRRWDGSKAIFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Q4</accession>
    <name>A0A0N4U8Q4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Archease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS305</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Q4"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Q4"/>
    <dbReference type="WBParaSite" id="DME_0000343901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000343901-mRNA-1"/>
        <property type="gene ID" value="DME_0000343901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2190767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.10.10:FF:000001">
        <property type="entry name" value="protein archease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000343901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16910" checksum="CB6E718D412427D3" modified="2015-12-09" version="1">MTKEPVEVKYEYLDHTADVQLHAWGKTLEEAVEQLLVSMYGYMTELSSVNVEYSFDMKASGIDLISLVARLLDEALYCFSTEPFFVGRIAEVLSFDRQKFEISVRCWGDSFDIEQHPQGTEIKAITYSNMQINETSERTDIFVIVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U926</accession>
    <name>A0A0N4U926_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7573</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U926"/>
    <dbReference type="WBParaSite" id="DME_0000356801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000356801-mRNA-1"/>
        <property type="gene ID" value="DME_0000356801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864015at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000356801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="52165" checksum="AA0F0BEEC74C4373" modified="2015-12-09" version="1">MEKTKVGSKKLQPIIKLPKLQHMKSDGSIRRSLDPGEKLRYLISCLEGEAKELVEEFRMDGESYKIAWEILESRYGDKSIINEELYKELRELSPKTKDIKDIQKRKCLTWNINELRNLMKAREEEELLSGRRIRSGDKKRLPKHKIINNFKEENSHDREQSERIKSTMVSSKLTVKRNIKKCIFYEKEHWGYQCKKIASYEEKLQLIRKLQRWFRCLKLGHRASDYYNRIKENSIVNEVFLPCREVFVINPLKPRKKIRALILLDMGSQQSYISETLRENVAPKIPQKYHTLIAEVGIILYDGSIFKIMANTVTQLTSQIKYMQLKAYQSSRTRGVIKMAKPDILIGSNYYFFLMRSGIKNEKKDSGGYVIDSRCYMANKECPSLVTFMVLAEQDLSQFWALETIGIAINLIDDEEAYEQFEKSVRRNEEGRCAISWPWKSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U952</accession>
    <name>A0A0N4U952_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS7602</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U952"/>
    <dbReference type="STRING" id="318479.A0A0N4U952"/>
    <dbReference type="WBParaSite" id="DME_0000359701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000359701-mRNA-1"/>
        <property type="gene ID" value="DME_0000359701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN57629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000359701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20298" checksum="809642B547522FAE" modified="2015-12-09" version="1">MSNIGSRRKNPLNLSLPATVKENDVTKSNEEEELGGSNVRTFSLEEQIKQMTLTEPQKRRMQEFMQEKKQIPINELSEDMLEKICELGHGNGGVVSKVMHKPSKIVMARKLVHLEVKPSVRSQILKELDVLNKCNSPYIVGFYGAFTDNNDISICMEFMDGLSLDVILKKVFNCFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9M6</accession>
    <name>A0A0N4U9M6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCDC22 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9M6"/>
    <dbReference type="STRING" id="318479.A0A0N4U9M6"/>
    <dbReference type="WBParaSite" id="DME_0000380001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000380001-mRNA-1"/>
        <property type="gene ID" value="DME_0000380001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825860at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048349">
        <property type="entry name" value="CCDC22_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21674">
        <property type="entry name" value="CCDC22_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 N-terminal" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000380001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19464" checksum="9571225539B494B4" modified="2015-12-09" version="1">CLNYFSTFFCEFSSIPTNLKEIDSEKIYEAIVLFIWQCDPSVRIGYQTLLYGQSNELRNIFIGLIEKLPKDSSSTTTNSGLLKFKSYNHIMNGINFRPKPKPLVKAVDKTKLQNIELNNESVYVEKDEILENDEISNGDAGQALYSAILMEQIKIHQSLLERKSALFKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9V5</accession>
    <name>A0A0N4U9V5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7898</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9V5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9V5"/>
    <dbReference type="WBParaSite" id="DME_0000389301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000389301-mRNA-1"/>
        <property type="gene ID" value="DME_0000389301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873825at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053031">
        <property type="entry name" value="Cuticle_assoc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396:SF25">
        <property type="entry name" value="BOUNDARY ELEMENT ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396">
        <property type="entry name" value="OS03G0264950 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="7">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="7">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000389301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="737" mass="82732" checksum="DAB4C74F9FC7B356" modified="2015-12-09" version="1">MISTQYWRNILSRITDDEHKNDLDLDALLMNKDLSQDEANERKDCENIANLQSPLSDEGESSNQGTSSSRPEKKHHEDSHETNCDDESIASEISEITRSWNKSEVKATISGLNGADEPQPSSSSSLSSGSSSNNSQAKDKDNRPVRSDENTNIIHRDEFKMDMGEIRGLHLFNGQVQLDEKIKTPPKLKQILKKKRQRRNPVWPYFEVRDNNAYCKQCSYNTRSVFSTNLKVHLRTHHPLLYEEVKKAEDEQLRANQSANDPTTSTFIAAHQYLQQVTNALSANNLCINQKVIGDRCSATRLDLTKTCLKGNQNSAKLPNLSSVCPKKSNDLIEQSSTSGTEDATKPTFDEVCSQLLNCMKNDESLIPRGQLKPRRLRRHPVWNFFEDIDNSKIIKCMKCDFQTGSAYSTNLKMHLKAHHKKDFELVTRLEDEQRKADDLQRIQLGKRKISGASDTAESSTNQSTNQLFRRDIDLSVVKKSNISNEMKIYDDPVIEEDRPMTHFEQLTAYVESETEKIKLKDKEEELREETTDLSVLNSNAILKAMVNECSVKPLSSLDCLHSSVSLLKNILPSSGSSVSESRSPSSTSALNPADQQNSPLTSSFLAPSQKCLRTVNKKLPTGEVVKIRSRRTDVNECSDGTNLSKKTGNFVFKQAVVPALRSALSTVDAAVLQRSNIAATKQRAGDAAFIKLIKAQASCFQLLDISEFKAFLKAIAPDYNLPSKEEIILQIQLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAW3</accession>
    <name>A0A0N4UAW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dickkopf_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8199</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAW3"/>
    <dbReference type="WBParaSite" id="DME_0000431601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000431601-mRNA-1"/>
        <property type="gene ID" value="DME_0000431601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000431601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32058" checksum="E0A9353370661764" modified="2015-12-09" version="1">MSGNECAIKSCLPRLTEPGFRCSSMSITHHATAPQQQKVATLKNILEKYGKCLRRKRPKLQPEPAPEPEPEPKPKPAPQPKPAPQTKPKPLPQPEPEPNRPIPPPSVTEGTQPPIKKTTKPIVQVTKTTKTMMTTKINRKKPNGPNLPAVKEVPKMPIEKPCKHDNECKEGERCYGRTGVCKAPSTIIKQCFSHSDCPKGQRCEKNANGKLVCAIPKGQVQRKDCSNDFGCSEDEICVNLGTLTKTDFQCIQRPSEMYENCATDSDCGFSQVCFGAFRRCVSSEPIQRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBE6</accession>
    <name>A0A0N4UBE6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8405</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBE6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBE6"/>
    <dbReference type="WBParaSite" id="DME_0000452201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000452201-mRNA-1"/>
        <property type="gene ID" value="DME_0000452201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000452201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11362" checksum="C97DF82BA046B150" modified="2015-12-09" version="1">MSAADGGAAALLVAGLNTNGPEVMYEDDLSDNTIPDIQKITKKNNILPLWGNNQTMNLNALVLENIVQCTYYKNYLAETTGFQQLIEEIYYRVSLRNCDLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBI2</accession>
    <name>A0A0N4UBI2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8445</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBI2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBI2"/>
    <dbReference type="WBParaSite" id="DME_0000456201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000456201-mRNA-1"/>
        <property type="gene ID" value="DME_0000456201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000601">
        <property type="entry name" value="Nitric oxide synthase-interacting protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000456201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="604" mass="67783" checksum="615F7CFDEA3CE792" modified="2015-12-09" version="1">MTRHGKNATASAVYSYSERRKDATQSGYGTLHQRLGADSIKEFDCCSITLQPCRNPVISPNGYIFDREAVLEYYLTQKKENAKKLKEWEKQCMKDEEERNKEKSMVETVKIMKFMIAEETPTHPGARSSLGDLTPTTSAGATASGSQVGFDVYVILFFVSIYTLPLFWDQTVRCPVSGRPLKIKELLPVQFTKVDDEEDNSKKMRYMCPITHDIITNTTRCAYLKTSQVVVTMDCVDKIIRKDMIDPINGKSLMDTDIIELQRGGTGFALTNENPSSLLFSIFSMAKVMENDGFKRPALPVSLTQSMGPKRPRFEVVQSGHTKSEPVRLSQLQAPIMLLSGHEGEIHTAKFSSDGTFLASAGFDMFPVLWNVYGDCENFSILKGHTGAIMDLHFNSDSSLLITASTDKTARVWDMETGTCIRKVHDIRKRDPVVCFANKYQVTAVCFNDNAEQVISGGIDNDLKVWDLRRNDLAYVMRGHTDTVTALALSPQGTHVLSNSMDCTAKMWDIRVYSPEVRCVKSFGGHQHNFEKNLLKCAWSPDNNYITCGSSDRYVYAWEVSSRRIVYKLPGHQGSVNATDFHPKEPILLSASSDKKIFLGEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBL0</accession>
    <name>A0A0N4UBL0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Laminin EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8477</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBL0"/>
    <dbReference type="WBParaSite" id="DME_0000459401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000459401-mRNA-1"/>
        <property type="gene ID" value="DME_0000459401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10430210at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000459401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10446" checksum="C37367E2C8E3B4D1" modified="2015-12-09" version="1">MIPIWENNSEFSNDFDIFATDKKITIARSCSDLAPRSDCKWPHRASIRRTAGSSNLEVQLVGQCRSCSRDYKCNCCRQCNHVSIVYTPVGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBP6</accession>
    <name>A0A0N4UBP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8523</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBP6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBP6"/>
    <dbReference type="WBParaSite" id="DME_0000464001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464001-mRNA-1"/>
        <property type="gene ID" value="DME_0000464001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14306" checksum="A683C517A8758298" modified="2015-12-09" version="1">MHEMAIKQRLITDQDPRGNGFVQLSAEEKRTLLQEGFNLPIHLPLSKAEEDALKVVRRKIKNKLSAQESRRKRKEYVDSLEKKLHGYFSENLSLQIKQLEENNKNLLMQLKILQASPDTMHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ1</accession>
    <name>A0A0N4UBQ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8529</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBQ1"/>
    <dbReference type="WBParaSite" id="DME_0000464601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464601-mRNA-1"/>
        <property type="gene ID" value="DME_0000464601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF74">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="300"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46952" checksum="AF74BCD8416CB107" modified="2015-12-09" version="1">MDDNVFVDIDSDGNATNGSDNNDINDLYETMMEYSHIFPVNSEKTAENSVITPEMDDDLCANEACIVSIAESQSLFYSSRRSIRYTQAQSYKGNNNQFSDSLKYGDYKLNNDEHIIRITQKDICIDAVTFHNYSIQIDFHCLLVFVVNFYKCEKFLEGYNFTIISLSPTNPLLEKYGVNLNTSFIWHAELAGEIIPEECEMRHGNREFMVKKRDPSQWTSGLLHSHSSNVLSSLSSYQPTTRPYSSRFTGSYRYSGLSSYNSFSSNANDSSSLTNRPTSYSRSMYVSSSHVSYSPLYHVSNSTSTQKTTPSQSSANLQSSSANSLPRRWASSSSVLSPPSSSSSSFISTNDVPASTTVTSTRSLFGRPTAMVSPYEERGIVTEPGFTGLRNIGNTCFMNATLQMLVNCKELQVYFLGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCC3</accession>
    <name>A0A0N4UCC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome associated membrane protein RAMP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS532</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCC3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCC3"/>
    <dbReference type="WBParaSite" id="DME_0000491101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000491101-mRNA-1"/>
        <property type="gene ID" value="DME_0000491101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000491101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7321" checksum="B446FF634051AEE5" modified="2015-12-09" version="1">MAPKQRMNIANSAFSKNVNSRGNVQKTLKPQEDKYAAAPWLIGLFVFVVCGSAVFEIIRYVKMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCF8</accession>
    <name>A0A0N4UCF8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8751</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCF8"/>
    <dbReference type="WBParaSite" id="DME_0000495201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495201-mRNA-1"/>
        <property type="gene ID" value="DME_0000495201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51580" checksum="22C084AD8E4F9C95" modified="2015-12-09" version="1">MAFYTIEKDTSLMPIKCWQRCSCLDKKYLEISGRCVEISFVDANGPSQKKTYLLNKVVNDFECRMVGRSCGENMVFEIISKLNGSCVDKCVCAYNFVQNNIGCDRCDWDEDDANDNDLNNLYASLPVPITVRLGQRIYDKRCIISGQTCGINMVFEAINNVKNAYCIQKCVCDHYSKEKNGECIAKRNSECAKNLRKALKMRKEKEIRCIRTRTCKLNEIFYEIQCILQEYSCGPNMQLVVIDKRPSNNVNRWKCVMQCQCVYGYIETSNRCSEIIKGVKERMNCMRGRCMLNEVVQDNGCSLKDQFCGRNMKFTLIKQSMKNNHISCIVQCKCAEGFEEENGQCRKHKNSCLENGCKAGMTIHDEGCHLTGEKCGNNMVFTMVNSGVYIGKEYNVGEEISDLGCRLRNFQCGTNKKFIVVGEYSAKHNPNIKGCIERCSCIMAGPGDCMHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCP0</accession>
    <name>A0A0N4UCP0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zf-rbx1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8842</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCP0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCP0"/>
    <dbReference type="WBParaSite" id="DME_0000504301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000504301-mRNA-1"/>
        <property type="gene ID" value="DME_0000504301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000273">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger RING-H2-type" evidence="11">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000504301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14642" checksum="C512CAF08BB1E0BE" modified="2015-12-09" version="1">MAEIAELMEYEEGSKEKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQLGPVSFELWVMGVNKCTFQAAPTTEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCY9</accession>
    <name>A0A0N4UCY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8957</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCY9"/>
    <dbReference type="WBParaSite" id="DME_0000515801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000515801-mRNA-1"/>
        <property type="gene ID" value="DME_0000515801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000515801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11543" checksum="028A857418AA9C40" modified="2015-12-09" version="1">MDEEKDNLIDNHRDDLQSENKTITTIINYDDEDICKNFVENETINGTSATIHRPFLEGHRDSIWMSMGINMTDEERRKRRMSRRRESLDAEQQLASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDB8</accession>
    <name>A0A0N4UDB8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">P53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9114</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDB8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDB8"/>
    <dbReference type="WBParaSite" id="DME_0000531501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000531501-mRNA-1"/>
        <property type="gene ID" value="DME_0000531501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5915660at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054106">
        <property type="entry name" value="CEP-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF16">
        <property type="entry name" value="P53 PROTEIN LONG FORM VARIANT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF21907">
        <property type="entry name" value="SAM_CEP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="13">
        <location>
            <begin position="146"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CEP-1 C-terminal SAM" evidence="14">
        <location>
            <begin position="421"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="12">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-3"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21907"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN59141.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000531501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59987" checksum="B6FE0B6DE76E6E3A" modified="2015-12-09" version="1">MENRGEKGIHMNSHLSNFDDQSALSQEVSQGLIFLTSKKESDYSHQCGEQIYGDKSLDNEAFVIMDNDEYFVDIPSNCSGSDIADILCKRIADGGLNYSADENLDCNYRTNIETSYCSETVGDFMNDPRHANQNMKGSMMHWRSSSSNVGSYGFNVKIEPAIKRRSADYILFAFLSSGFFCGKRYLQYSVERDYLYAKPFISIPFAILFHTETPTLSVLRIFARYVETAYASQPVHRCPLHLASDGVFFSICTREHFIVVDIPEAIHVSGQSSFPFPHVMITLSHPSVPFFIPVQFQCYSSCSGGINRRPLFLFFILEVNGELVGEQRMSLKVCAYPSRDCASDEQPTMKKRRKCISPVMEVVTQTHYDKAHRKSFEEDDETIYEIQVRGRHLYKLISSIIYNFELGKRYVKEKVSESRYMHSVYSNESLSPRMPISVWLKKINQSQCEDLFNSRAFFLLSDLEGKINKQFLASMGMDDKQISSILNSYLSWFNVYNAQRLSDLSSEGSSIRIQRTRIRNSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDX7</accession>
    <name>A0A0N4UDX7_DRAME</name>
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        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DME_LOCUS9295</name>
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        <name type="scientific">Dracunculus medinensis</name>
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        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Spirurina</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DME_0000555401"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59322.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000555401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="13805" checksum="79EB2C09C3EA12B2" modified="2015-12-09" version="1">MCADGSTQYSYRESINDFSKIEVAGKAIMSLNCESLGPSGANICVCTPSRICYRGNNTGMSILLASYCTKDLIPLCGVYGKISGNNADDALVSNNHPPITVGSQFAAGSLKPIPNGFINIASVSCGNCAPVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE31</accession>
    <name>A0A0N4UE31_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS657</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDN50684.1"/>
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    </dbReference>
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        <property type="gene ID" value="DME_0000561201"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="VDN50684.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000561201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54122" checksum="1427F2C970A7147E" modified="2015-12-09" version="1">MDIAYRYSRGVRISPEHRITDLEYADDIFLFADSYNEIQVHITDRAYKISQNYIYLRSNTTCINNVITECGLSWLGHILRLPPQELIHISLFAKPCDGWRQNRGPIKILTDTVLGGSRMLNAKAVPVPNQKFAYVEMEERRNASLIPKSSEKNLKNIDFPASSSATTIHLGTRNISVENISLPSTQFIVPEGRSNLPQRERRSNLCNIPRTSIDPAPPEAMQNAPSESVNEYKADFASSETADNVDPHIDTVVEGDKISAQSAKVTTIKPCADIRDITFAESAVDNLKFLSVSPPRSCTSLTVKAVSQPQPSCSDSVSEEEEEEEDMNLEEPIRLPFASCKLISCQDDSSHPLPNKIAFDRESSPMNNQNSSSVVMKENDPKLMENSSLKNDSVVDSRVTGYITSALDNSGQNGIAIVISEMTHSVLIEWKPVTCMAYARFKESLSKYNMVIIEGVWNLCVSHDATKINLVIGIGVDAPLEKAFAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE99</accession>
    <name>A0A0N4UE99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE99"/>
    <dbReference type="WBParaSite" id="DME_0000569001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000569001-mRNA-1"/>
        <property type="gene ID" value="DME_0000569001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000569001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8230" checksum="38B8E1305EC18028" modified="2015-12-09" version="1">MSATLSKIEKKFKQKYDEFVSGGKLEEGLENIADSVETLADRIFPSEKKKSPPVPIFVEVVISTGTGLYVFTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEN6</accession>
    <name>A0A0N4UEN6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9373</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEN6"/>
    <dbReference type="WBParaSite" id="DME_0000584901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000584901-mRNA-1"/>
        <property type="gene ID" value="DME_0000584901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000584901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7783" checksum="E57E316777D31D49" modified="2015-12-09" version="1">MSQFLMGIPIWACYVFGGCFLLIIIVLLLDYLLIRRNALGHSCLQFSATWRHYGPVQPKRSTNILLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF16</accession>
    <name>A0A0N4UF16_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS944</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF16"/>
    <dbReference type="STRING" id="318479.A0A0N4UF16"/>
    <dbReference type="WBParaSite" id="DME_0000600501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000600501-mRNA-1"/>
        <property type="gene ID" value="DME_0000600501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000600501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19190" checksum="9D5760EBFC88DE42" modified="2015-12-09" version="1">MADNVQIKTDDLHKLKEGEIFVDAETGKKYRVRKTFLPQHIGGGPHGLGDPNDRTLRHIEADVIIPYQMNTEIERVECHKQYLDLVHCMKTEGAIRGLKLCRPILTVYNKCKAEKFRDPEFRERITEQFLNERSEYRKTGLNIKEREFQTFRTSRVKEPDENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF34</accession>
    <name>A0A0N4UF34_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS965</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF34"/>
    <dbReference type="STRING" id="318479.A0A0N4UF34"/>
    <dbReference type="WBParaSite" id="DME_0000602601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000602601-mRNA-1"/>
        <property type="gene ID" value="DME_0000602601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000602601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26700" checksum="4D396CBBE68DE8BC" modified="2015-12-09" version="1">IFAFFKDFIKSRSTESILCLLRVVTVVCAIYYILPIGSRSAQTAAYSKVFIAAAATNALRAHQRVGAIQFSREFLGRILVEDSCHYLLYSLFFLTVSPVTMALVPVFLYALLNACSFIVQLFNAIGNGSNAAIRKIAELTNANTQNMLNVIACSEILVMPILVVMIFAGKASIFHPFVYYRFLTLRYLSRRNASTRMAFYHLRVFLEKTVSSPSCPQIIRLIVHNLIAFTCRLCPTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD0</accession>
    <name>A0A0N4UFD0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynamin-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9429</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD0"/>
    <dbReference type="WBParaSite" id="DME_0000613301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000613301-mRNA-1"/>
        <property type="gene ID" value="DME_0000613301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256226at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="83"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000613301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="815" mass="94332" checksum="619EEA3ACBA6304A" modified="2016-06-08" version="2">MSANIVGYVRNHKSVHQGKEPLKRFAEAKKFMGDIYADLEAYIDELTKFYRDVINGQTIVPDEQMQEVEKFKGSISTIRDMFMRDTMKVAFFGRTSNGKSSVINAMLHSKILPQGMGHTTCCFIQVEGSPDNEKYIISENSTSPINISELQRLASAVSDDNASMGQDSLLHVLYPKSESRLLQNDVVIVDSPGVDFSPEFDNWIDKHCLDADVFVLVCNAESTLTQSEKNFFHRVSSKLSKPNIFILNNRWDASAAEMEHMQQVKEQHMIRFKEFLVNELNVCSEHEAKDRIFFISAREMLDARLKERNLIKIDVLFFYIFFKIILEWFIIYLFIAYQMEGHQFRAMEFMNFETQFEQTISKSAISTKFESHHRRAREIVNSMRGNLEIVQINAVKRREQLQQNYCNREEEFKQGLNSWKEFERFAITESQRLKNEVHLKVSADYYEEIFRLESIIDKFDGKFIDEPSCILQYKKADSFNFYISFGIRNFCHEYLHSFFFIPLSLADFLDKVVKENLEIRCTGGLMQRIWNLENNMFEQIGRILPEPYSRKLDEVWRYRAPFRFTICVNCPSLMEDFHEDLIFRFSLGLPSLIRRFIAFRSGQPVTAISNNYFLQAFKKNELTDSGGEATSSQSNQVARHEAEIFNRRDEDNALITQVVLSSVGYIANGGVGLLVIGGLVSRTVGWRIIAVSGLLYGGLYALEWWRWNSGAKEQHLKDQFRSHLATRMRNMAASHTSNCESQVLWEMQQVFNGLKATVGGAHQEMKNELDETQQKIGNIENVIKGLNTIKGKTAFLNTDLDRFDLEFLQADSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFG8</accession>
    <name>A0A0N4UFG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA_decap_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1077</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFG8"/>
    <dbReference type="WBParaSite" id="DME_0000618001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000618001-mRNA-1"/>
        <property type="gene ID" value="DME_0000618001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5827290at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000618001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36978" checksum="12622253BF0BB056" modified="2015-12-09" version="1">MGKHWIAAINKMSFEVSSRSVDNLRWNIIKYTKLFPCRIEICSNIGQLFVVLNKSRRCLNVFNGSSVLEEFSLISIPKPIVKSRDQDLLFQVNKHNGVVLTRFRIKFMLTDEHINISNYISFFINIIPSKAFANDSFSNMSADFIHSQPISQDESFQVTQSGSFIIDNFSQPQYVNHLNEYNKECSNWQIAFPDNKSSEVMPTKNFAMAVEPLGVPLAAMKPSDQVVPVLIDPNLSLASTQSYDNDSMNNPSQFSLRYSQISNHINPSTEAETQTTNDSITIDDMLLREDLLEKILFLKLNEPKFIALVEKCTAIMDRIYTISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFK7</accession>
    <name>A0A0N4UFK7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1125</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFK7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFK7"/>
    <dbReference type="WBParaSite" id="DME_0000622801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000622801-mRNA-1"/>
        <property type="gene ID" value="DME_0000622801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447516at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000622801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51784" checksum="B3B42279B7A281A1" modified="2015-12-09" version="1">MFDKDTSALGFDITDCFNAIYINNVHPNGPAERSRNILIGDKIRALTVSFEGMKLEDAIALLSCASSYKQLELQIKLELERAIVEETEEITYKDGTEEMEDREVVKNNFHVQSFKSISVEDLKIENPCKNTYEYVLLMWNINEWIDEKEASMIVIGEGNSYSFKRTKSCMTNQKYPLPPIMQQPSPLLDSKSERMAINSRKIQKAQANRQTSPAVSGSRTISPSASINATSASFNALPEYHLDISAMSAPTEELTILDSLTNVEDTTKSLPTFIDRPSIDSTSLETRSSANGFLSTDPELGKSILPSSSSSASSVVSSESKSSLPTNNSTISRIPLLGYSPKPVPLQIRKYVPEKPIIIEEVDRRSITEIIEVTVPIAAVITTLAFTFHMFFQSLTKFLIICYLPQLPQLSIDSASHEKSCFAQKFPCIVKSLWVFTSAASISSFVHLMLKRVLEYLQTSATHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG44</accession>
    <name>A0A0N4UG44_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9554</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG44"/>
    <dbReference type="STRING" id="318479.A0A0N4UG44"/>
    <dbReference type="WBParaSite" id="DME_0000644301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000644301-mRNA-1"/>
        <property type="gene ID" value="DME_0000644301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000644301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23588" checksum="FCA7899EF7E96F3D" modified="2015-12-09" version="1">MFNILKVSLKDFETLLDIEVPYIENAMKEVSELEEILKSELEKHFSSSVNIRTFEDVTVQMDDGKQLKLNRLAKIVLKAPMIIQMDFTSNPASIKAAKLAIMNNLNVNTQQDGICLYATMPKMTRARREELARTAETKLYNEYRLALNEVYVKYNKKAEKELTKQDELRVIKSSLLTLKRGMECKGLDMIEECQKKLLKEEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGB9</accession>
    <name>A0A0N4UGB9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9641</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGB9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGB9"/>
    <dbReference type="WBParaSite" id="DME_0000653001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000653001-mRNA-1"/>
        <property type="gene ID" value="DME_0000653001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000203">
        <property type="entry name" value="NADP_transhydrogenase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="13">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="12">
        <location>
            <begin position="201"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000653001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="49808" checksum="0745790068C788E0" modified="2015-12-09" version="1">MWWGRENTHMGWYFEKRYCQRILLGKGKRKMKILLISLKRNFANVAAASGRPWKDITVAAIREVSQGEKRVAITPQAAESLIKKGIRVVIERGAGVSASFNDDLYQKVGVNVVDKDTAYQSDIIFKVRVPTLEECAKFRPKSTLLSFIYPAQNKNVIDELAKRELTVFGMDCVPRISRAQVYDVLSSMANISGYKAVIEAANHFGRFFTGQITAAGRVPPAKILVIGGGVAGLSSIGTAKGMGAIVRGFDTRSAVKEQVESLGAEFLEIQIKEEGEGIGGYAKEMSKEFIEKEMELFSQQCKEVDIIISTALIPGKPAPRLITKEMIATMKPGSVIVDLAAEAGGNIETTRPGQCYTNSNGVIHIGYTDLPSRLPTQSSPKEQFNVDLNDEVVRGTIVLHQGRMMWPPPVISSPPPSPTLAKKIEEKAVVEVPLSPLQQTFKSAAIYTAGNLNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGX3</accession>
    <name>A0A0N4UGX3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1376</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGX3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGX3"/>
    <dbReference type="WBParaSite" id="DME_0000676201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000676201-mRNA-1"/>
        <property type="gene ID" value="DME_0000676201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000676201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48219" checksum="33F8EF2B033AF493" modified="2015-12-09" version="1">MLALNVKIPSILRIVTSAIHTSINSGSNMPTPIVSSKTASFRKGTGGRCSFSGNVITVFGSTGFLGLHVVNRLAKQGNQIIIPYRQDPYYIRELKVFGELGQILFFPFELKDEESIRRSLRYSNIVINLIGTKIQTRNYSFTDTHVEGSRRIARLSREMGVERLIHISALNVSKEPTPGILKKGSEILKSKAFGEEAVRDEFPDATIVRPSLMYGEADYFISYYVSRLRKFPPFDFVWLHKSGLETFRMPVYVGDVSAGIEKIVLDPTSVGKTYEFVGPHCYRLSELVDYMYAKARCIEKFGFHYKRYGIPFAFNPVMRTATFMAEVWSKIFKCNTALMREWIEFVECTNDVLTGNPTLVDLGVRPLTEFELVGGQIAFLRPFRGYYEVSYGDIDPPRLPLRSPPLTSIKKATSGIFTETKPFAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGY6</accession>
    <name>A0A0N4UGY6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1391</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGY6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGY6"/>
    <dbReference type="WBParaSite" id="DME_0000677701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000677701-mRNA-1"/>
        <property type="gene ID" value="DME_0000677701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="469"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="610"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000677701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="676" mass="71290" checksum="498176DCEB7C5215" modified="2015-12-09" version="1">MELESQEFVRLKNSPSVILLNRATNERNLDGMILHQENVLGVPNGYVEIDKAGEYYCARSYGDCGADLPIFRFRTDSSSATKYAYSFGHEATFPGYMKELIPMSAQNKCQTLSNVSDGQIIYQHSEKGITPVGTSATLKCDEGLVPAGISVLICTNTGWYPHGTLGQCVPNVSGAKVDSWNAITISCPQLSNPDNGRIIYSQYQSNNLPNGTLARLQCSDGFLSTGSIKQIKCEYGRWSPPSLGLCEKISDKCQELPNVPNGEIHYTNYDSNHFSVTSTAELFCNDGFRNDGLAMLTCQIQGWYPESSLGPCNHVSFFSYTSNQQCTIGFPQPANGNILYSTASNSAPFPSLTIATLICNLGFSALGNTSSTCINGVWTPSQLGECSALGNRASVNNPLILSQSQCMVGLPPVFAGQINYSTTSTVPPFPSGTTATLVCNTGFSPISNTISTCIGGLWNPPTLSSTSFGQCPDVAPVTNGFIKYSDGGASSHASNTTVIVSCNLGFSLSGTASSTCQNGLWIPPVSAICTQSNSNSTQGSCMGIMPPLYGNIQYSTSSLTTYPSGTTATLVCNLGFIPSGQSSTICKSGQWDPPILGINGGLAVAGNTGASCNLEIPSVLNGAIRYSLGTTAPFLSGTTAVLTCNSGFMPNGNTLSFCSNGIWSPSFGQCIAPGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHK8</accession>
    <name>A0A0N4UHK8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHK8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHK8"/>
    <dbReference type="WBParaSite" id="DME_0000704301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000704301-mRNA-1"/>
        <property type="gene ID" value="DME_0000704301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859289at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000704301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="53812" checksum="3E434C10CA19B365" modified="2015-12-09" version="1">MALEVLHKIVVQPDLLASFCKNYDERPNSNKIIQTIGYKLSACMQLCLLYPDVNDAKKDDGQFESNCQAAESSGFVCKGFWIPLYQNISRKKLDSLEKHEAMNLPEGYTLSLAYACITDFCQSIYQIDESMDVCKSIFELSYSSLLAALSILLDASIDESVTDHILHSFSIIVSLACRLGHVVGRDAAIFVLCKAGLPYNYFIRVFGNTGGLNSLSGLVDTICTVDASSLKNVGDNEGDSSVGPLNHIVAVGTPCPTPFLPGNFFGQSVVVTAKNIQVFRVLINCLQENGLYMGDCWHLTLASLQHLIWILGMKPCLLEGFRTDGDGIDSSSLISGQHNSNMLTTTVMTEVPIMTAMLNKLFDSTVLLDDVALHHVIAALCKLSNEAMQVLVSQSGSREPSFFPIAKLRQTALVNLSRIEIFWKPVTAHLIEISGHPYSKLREWGAEALMTLIRSAMKANINGDDVVSFFNFILFILYKYNYLFDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHU6</accession>
    <name>A0A0N4UHU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9875</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHU6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHU6"/>
    <dbReference type="WBParaSite" id="DME_0000714501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000714501-mRNA-1"/>
        <property type="gene ID" value="DME_0000714501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21188">
        <property type="entry name" value="CH_PLEC-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000048">
        <property type="entry name" value="Short stop, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="46"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000714501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25017" checksum="A59ADA0E53FFFF6B" modified="2015-12-09" version="1">MSFSSSTNLYSSDQSSSEYYFIQCYENDSLEHYEINLERYKDERDAIQKKTFTKWVNKHLSKTGRRVEDLFVDLSDGLNLIALLEVLSNEHLPHENGFTRFHRIQNVQYCLDFLKAKNVCQVKTVNIRPEDIVEGNSKLTLGLIWTIILNFQVSIIKQRQYEISNSQVKDLILYLFLFIFCYFHFTSLFVSFFLFSICHLLLLNFSSSSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHW8</accession>
    <name>A0A0N4UHW8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS1639</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000027">
        <property type="protein sequence ID" value="VDN51666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHW8"/>
    <dbReference type="WBParaSite" id="DME_0000716801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000716801-mRNA-1"/>
        <property type="gene ID" value="DME_0000716801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF32">
        <property type="entry name" value="ADP_ATP TRANSLOCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="126"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="225"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN51666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000716801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35629" checksum="F7C5D26E4093FF59" modified="2015-12-09" version="1">MPLWNDQHVIKTAKEENIPDTAIKFGKDLAIGAVAAIIAKTIVAPIERVKLVLQLQNAQERISVTKRYRGMMDCFIRLPREEGFFSFWRGNLVNIARACSQESLGFAFKDFFKIWSLSGVSNDSYWKFFTGNIAAGGASGISTYCVIYPLDFVRTRLAVDMGKGVNREFRGFFDCLKKIIKHEGVRGLYYGFGPSIQYIFIYRGAYYGLFDSAKVFAPSNEKKQISFLSAFIIGQFVTFIAAFISYPWDTIRRRLMMQAGRNDILYRGFIHCAKKIYYEEGFRAFFSGMLPNAVRGSGAALVLAFYNEFSKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIB7</accession>
    <name>A0A0N4UIB7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9977</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIB7"/>
    <dbReference type="STRING" id="318479.A0A0N4UIB7"/>
    <dbReference type="WBParaSite" id="DME_0000734101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000734101-mRNA-1"/>
        <property type="gene ID" value="DME_0000734101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6127080at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000734101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18870" checksum="2D4E51D2672ED2D1" modified="2015-12-09" version="1">MYCIAVEGIFHFFMRIFLVFIVIFTILHEIIECRGGRRAGKGKGKSNLQFAQVAEFSLIQTPPADNRSAYIITGSHFSQSFRLGYKLVLICKAKGSPRPTIKWYKEGTEMHPKSSAHYYEKPIGEFTMWSKLEIDPATMGDQGIYACVANNEFGVMAKNFKAEFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UID3</accession>
    <name>A0A0N4UID3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS9996</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UID3"/>
    <dbReference type="STRING" id="318479.A0A0N4UID3"/>
    <dbReference type="WBParaSite" id="DME_0000736001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000736001-mRNA-1"/>
        <property type="gene ID" value="DME_0000736001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000131">
        <property type="entry name" value="trans-2,3-enoyl-CoA reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049127">
        <property type="entry name" value="TECR-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21696">
        <property type="entry name" value="TECR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="16">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN60023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000736001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="707" mass="80684" checksum="936AED690FDE5104" modified="2015-12-09" version="1">MDQLNIEKSSNICETIYAEVIRTKKETSEDVAKIFMMAIVSMEIVDAKNMQNSIATIENLSPDETILSLKKRITQINGSLSVERQSLRLDARGKNLNDETYISDLNLPSKGAQLFLKDLGPQISWKTVFLAEYAGPFFIYPVFFFRPGIFYGIMSHDQSINVTSSVRLALLCWTFHYLKRLYETERIHRFSNATMPRFNILKNCAYYWGFCAFISYFINHPHYTPPYFGNVQVFLGLIGFLLSEFGNFSIHVALRELRPEGTKKRKIPYASTNPFTLLFNFVSCPNYTYEIAAWLSFSIMIQSLPAFIFTITGFIQMSIWALNKHRVYLIEFPNYPRTLWDLLIDSILRMAWNEWQAVLLCSGSGNGLLPITENNPKCLVPVAGLPLFWYQLKFLEMNGFKDVFFVVPERSYVKISSLLNGRIPPLHDLNINYITMEESTAEWGTADILRHIEEKINRDFIVVSGDFVSNVDLMPMLSLHRSKNSALTCLLAKNAAQGSVPGSTIKRSNGRDLVGMTASNQLLFMSPEDDIEDRILIEPEFLMKLISARKKYIFKKQGKLIACNKKSETDELINKLNPGSIHSMNGPSFQCFAYVVTSNEQLFIAHCNNIGAYFEANKAVFFHLLPIVIVDFLPLFDENFPPTCKLKDIAFVCDSYIVSNMRLTERNISTTDKPVIKRSVIGKNCLLGIRTKILNSLIMDRCVIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJT1</accession>
    <name>A0A0N4UJT1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">DME_LOCUS2060</name>
    </gene>
    <organism evidence="34 36">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33 35" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O</text>
            <dbReference type="Rhea" id="RHEA:38379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38219"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38220"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38163"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:38164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38435"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37915"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:37916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55340"/>
            <dbReference type="ChEBI" id="CHEBI:34116"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:197429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:55341"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:138735"/>
            <dbReference type="ChEBI" id="CHEBI:197429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:55345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38307"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:75729"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38308"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:55296"/>
            <dbReference type="ChEBI" id="CHEBI:45479"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:138722"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38439"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:38440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37911"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38071"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:38072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:11488"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="2.3.1.76"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:11489"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38175"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:38176"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:10869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hexadecan-1-ol + hexadecanoyl-CoA = hexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38167"/>
            <dbReference type="ChEBI" id="CHEBI:16125"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75584"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA</text>
            <dbReference type="Rhea" id="RHEA:38211"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75608"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:38212"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38171"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75587"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:38172"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer or homotetramer; both forms have similar enzymatic activities.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 29">Endoplasmic reticulum membrane</location>
            <topology evidence="8 29">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 29">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJT1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJT1"/>
    <dbReference type="WBParaSite" id="DME_0000793501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000793501-mRNA-1"/>
        <property type="gene ID" value="DME_0000793501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050252">
        <property type="term" value="F:retinol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027251">
        <property type="entry name" value="Diacylglycerol_acylTrfase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500231">
        <property type="entry name" value="Oat_dag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 29" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13 29" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 29 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 29" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="30">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00001349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00001764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="VDN52087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="WBParaSite" id="DME_0000793501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53995" checksum="FF774B6960C71D4A" modified="2015-12-09" version="1">MDSNEGIKRKRSSAISRNQQKSSISSPSSNTKNISFSLNRPIHIAQDSLFSATSGWTDYRGLFNLAILLLFVSNGRVALENLIKYGILISPIEWIHFAFTDPWSWPNLTLTLFSNVTILLVFFMEKAIAMLWIGEIISRCFYVLLFSIHIICPAAVILFIKSNPLYSCFALSIYVVLFLKLTSYVHMNYFYRSLKIITRKKNISQNTSSYPNNINLKNLYYFIFAPTLCYEIRFPRSPNRRKSFMVKRSAELILLTIIIVALSQQWVIPLLRNSVEPFSTMKLDRCLERVLKLAVPNHVIWLICFYTIFHSALNLIAEILRFADRQFYLDFWNAETISEFWKSWNIPVHRWALRHIYLPLISAGYSKMIAAVAVFFVSAFFHEYLVSVPLHMFRLWAYYSMMIQIPLSFLTEKILKGGRPGNIVMWLSLILGQPMAILMYVHDWYIINEPSAVNETIILRGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK07</accession>
    <name>A0A0N4UK07_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0729 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2151</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0729 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK07"/>
    <dbReference type="WBParaSite" id="DME_0000802601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000802601-mRNA-1"/>
        <property type="gene ID" value="DME_0000802601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062823at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026776">
        <property type="entry name" value="UPF0729_C18orf32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456:SF0">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14975">
        <property type="entry name" value="DUF4512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000802601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7920" checksum="895A5AF4F0CA89B1" modified="2015-12-09" version="1">MVCVPCIILPVILAIYLKFIQPFILRFLPQSWRSKFDAILYPTCPLQEQIELNATVNLNKNVTNKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL48</accession>
    <name>A0A0N4UL48_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal recognition particle 9 kDa protein</fullName>
            <shortName evidence="9">SRP9</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2478</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SRP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL48"/>
    <dbReference type="STRING" id="318479.A0A0N4UL48"/>
    <dbReference type="WBParaSite" id="DME_0000850301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000850301-mRNA-1"/>
        <property type="gene ID" value="DME_0000850301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000001">
        <property type="entry name" value="Signal recognition particle 9 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008832">
        <property type="entry name" value="SRP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017029">
        <property type="entry name" value="Signal_recog_particle_SRP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP9" evidence="10">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000850301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9088" checksum="A16D4A2E58706F3D" modified="2015-12-09" version="1">MTYFTNWEEFAKAVERLFLSDPNRCRFVTKYDHKNGKLVLKMTNDIVCLQYSTELLQDVKRLEKLTATLMRQIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL89</accession>
    <name>A0A0N4UL89_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pyridoxine-5'-phosphate oxidase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pyridoxamine-phosphate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS2507</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15818"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15150"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000064">
        <property type="protein sequence ID" value="VDN52534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL89"/>
    <dbReference type="STRING" id="318479.A0A0N4UL89"/>
    <dbReference type="WBParaSite" id="DME_0000855101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000855101-mRNA-1"/>
        <property type="gene ID" value="DME_0000855101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000020">
        <property type="entry name" value="PNPO isoform 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="16">
        <location>
            <begin position="71"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="17">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN52534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000855101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30431" checksum="C9CFA7797A64912D" modified="2015-12-09" version="1">MSALTRQGSGDNASSFGLKIEAKFFFVDWRRIYLNKEEPYLLEENLVSKDPFDVFDIWFKNVASKSDISFEEINAVCFSTSSNNRPSSRMVLMKDYGRNGFSFYTNYDSRKGKEIAANPFGCLLFYWPKVDRQIRVEGRIEKLPNELADDYWKKRPVKNRIGSKLSEQSKVIPSRNFLLEKKAKLEKLVEEEGETAVSRPENWFAFKAFGTVFLMDLGGYRLVPDYFEFWQGQSDRIHDRIVFEKSNFNGSNWKIYRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULG5</accession>
    <name>A0A0N4ULG5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2554</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULG5"/>
    <dbReference type="WBParaSite" id="DME_0000863901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000863901-mRNA-1"/>
        <property type="gene ID" value="DME_0000863901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000863901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20317" checksum="90A7CA120095C5ED" modified="2016-06-08" version="2">MQRKQQQDKELQRQQQQPSIELLKALLPTDNYQLEHTSDDDSNDPYFDKLLNNENIRYLKSIPEEESDEINSEKSGDCSTTLLLPAIHCASPSPLSPAITHCASTVIDLNKNGSSTHNELKYFDLPDLRAIDSDSDTSSINNSSSINRYEIDFNTMNDLDRDQSEFILENNPLFVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULQ8</accession>
    <name>A0A0N4ULQ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2634</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000071">
        <property type="protein sequence ID" value="VDN52661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULQ8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULQ8"/>
    <dbReference type="WBParaSite" id="DME_0000874301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000874301-mRNA-1"/>
        <property type="gene ID" value="DME_0000874301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000123">
        <property type="entry name" value="Cyclin-Y-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="362"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000874301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="66753" checksum="AE951ADFD4D2D38C" modified="2016-06-08" version="2">MGNHALCCLKNSSDSHRDKRIFDCGDCSNHQYINHTFPRENTSSNFLPHISERELPDEIGDDPSTHPMVRPTFMERSRSEMKLKENRRSCYILDCNKLTGFLLKKSNSCSTIFLDDSTISQPNLKNTIKCISLAIYYHIANRKNRTQERLMEIFEERLHPIIRDHVPIEFMTRDPDHRQIYRFIRTLFHAAQLNAECAIITLVYIERLLNYAEMDLCPSNWRRIVLGAIMLASKVWDDQAVWNVDYCQILRDTSVDDINELERQFLECLEFNINVPSSVYAKYYYELRTLAMANDLQLPLQPLYKERARKLEALSRMYEDKLQPDGRLINRRSFSAEKLFAKEYRSPMAHHQGNCFCEVSSIEQVPEGMRYVMNKHIDIDKVVVLNESVNGSGVKIFKDWEDRLDRSTYVESDVDEELLFNIPFRGNVKITGVILAGDLDSTHPASMKIFKDRPSMSFEDTSCKAEQEFSIKQDPYGHIDYALKATKFSSLTHLSIYFPTNFGAVNTRIYYIGLRGQYLSNIRQQASCYHYFCIAFQRECVCGLQIAITMYEARPMVKEHKNEFPDVVGRGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMG7</accession>
    <name>A0A0N4UMG7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTP1_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2830</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000083">
        <property type="protein sequence ID" value="VDN52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMG7"/>
    <dbReference type="STRING" id="318479.A0A0N4UMG7"/>
    <dbReference type="WBParaSite" id="DME_0000904001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000904001-mRNA-1"/>
        <property type="gene ID" value="DME_0000904001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057347">
        <property type="entry name" value="TANGO6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25267">
        <property type="entry name" value="TANGO6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 N-terminal" evidence="3">
        <location>
            <begin position="102"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="772"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000904001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="954" mass="109893" checksum="6FB4A8B8D1F2AA1C" modified="2015-12-09" version="1">MDECFDLLECATSADIPFMKTKIYPYDPLESLADNLETKMKAAGFRILISSQSCNQPSTSADSISKDSTFDSRIRYSNLVTELFSTICNHIKNCKVDDSSIVLSVKKLNNISSALQFFIATAVLPYLDEGVGTPMELRSNLIQFWKPLRNDSEFRIKQLISAANTFFLLLESCDSVKMLIINKFLCDVICVNEQLIELNEMSLLNKYEEFLTNEVFRPILIRAFFTVINGYSLKQKRIDSPNWLKEMIKDCGQRFREFGSIQLENRRRSLSGKLSKLCAKPNGIYHLATSLIQDNFDLFDNFAFVHSLARVILTRPRNVKNYYANILKQFMKVMQYHPSAERLSVWFAVTVDIAAEFASHTVTVHIFDILLHPWEALLHRLFNDFDREDFWNSQLDCSLKVLSIYFAKMPPGLKYREKSRLEKLFCLWLTLYGKGKNSLRIIETDNIALKEKYGKFINAIEKILKYVLIHHSTDYKEQAEFIIDQILNKNSLCELLLVEFNCKKLIVEVSDCDVGNQSLNPSFDYVILKRITSETAGQNFNLDFRLKTVIELVQRLENSHYQTLIFNLLILCVKEWRVNSIDELEPDTNRFVVQENEVINNATRKMSMQYIMGQLYSFLPDIDDESEENIASMVAFAQAIFDSTNNKLSAFSPMQLDVFAEDSSDELTETERNSIKMAMAIIGGTCISLHSSKLRNAVVPLSESLNIFCHLVEQIDIKRKTKYAELYDNAKQLLDYFCSTGIHLNISSPFTFDKNNEKAKNLMIWKNVDDLAEIFENLKDSSEAIRGHALIILARDVRLRKRVTLTAVESNSQIMKLIMKNVTDNDSYVYLAAIGAMAELAYWKDYFFNEMVEFFVDPCDKLRDIIDQDFDKDDDKEVFLLIQRVKVGEALGKVCRALGDMAPWYYDRLIDPLLSLIAHVDDEHLRASAICSLADLIKACRGRKIEKNIDEAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMJ0</accession>
    <name>A0A0N4UMJ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2842</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000084">
        <property type="protein sequence ID" value="VDN52869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMJ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UMJ0"/>
    <dbReference type="WBParaSite" id="DME_0000906801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000906801-mRNA-1"/>
        <property type="gene ID" value="DME_0000906801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851609at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000906801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37490" checksum="C6D8DD0BAD44D1D4" modified="2015-12-09" version="1">MNFFRSKKTSNKNLEKGFLLKEESYQQNICDDERLLKLFDELYGSISYKILKHFRQTISGAFLTLIVMIFVGCGMLYGGYLLEIGILRRQGDIFIVVLSMVLISNSFINLVPQYRSIISAVSLAECICDTEAFVENNKINENRLKSKLEIESGTQQMVIIQTIFDRKVGKEEWLSTQFFRRTNQILRTHKNGRLLLILGLFTTIIHGFESPTYNVTMGKIFEAMLEPRVRMMDKLANGAIAFVTFGIIAFSAKILTMFLMTTVAKHLAITIHINLIRVHFGSNLITLCKNEINALVLQEDNLSDCIISHILDILINESLKVLTRENDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMP2</accession>
    <name>A0A0N4UMP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMP2"/>
    <dbReference type="STRING" id="318479.A0A0N4UMP2"/>
    <dbReference type="WBParaSite" id="DME_0000912801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000912801-mRNA-1"/>
        <property type="gene ID" value="DME_0000912801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000912801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14161" checksum="2C3D6F73F8273F6D" modified="2015-12-09" version="1">MSYSVCISFNSVIFSRTASMGHGEVPFKIPHYTIYSNYRQFPQLLEHEERLKRIGLKDPWIRNYVHLFDKNHPHIIGFFPHLRSIVMAGWKFGAISATVLIAIEEGYSYMKYGKTSWDAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN33</accession>
    <name>A0A0N4UN33_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3019</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000096">
        <property type="protein sequence ID" value="VDN53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN33"/>
    <dbReference type="STRING" id="318479.A0A0N4UN33"/>
    <dbReference type="WBParaSite" id="DME_0000929701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000929701-mRNA-1"/>
        <property type="gene ID" value="DME_0000929701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000035">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="14">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="15">
        <location>
            <begin position="237"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000929701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40061" checksum="27654D0ACFA4CC8D" modified="2016-06-08" version="2">MNKWCSILVHLSSDPYFSRNSINLGHIIDVLLRDYDIHLLPEANGVNVTIELHVQGVTGISEITGDFELDIMYSEIWQDLRLSFKDLSVCATNITLKSDFRKKIWTPDTCIINSKNAAIHSSPSENTFIILYEHGLLWNNFRLKVKAPCKMDLKMFPFDSIQCQLVFESYSFNTDEVRLFWHDTPVTLMEKVELPDFDLTGWSTDHQRVDYPNGEWDRALVKFTFARRYGFYLFQSYFPTSLTVISSWVGFFFDVRSVSARITLGVSSLLALTFQFGNVLRHLPRVSYIKCLDVWMIFSVIFIFGTLVELAIVCQLNRWERERQIGSKVLGHWLNQTSSNANKCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN68</accession>
    <name>A0A0N4UN68_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3058</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000100">
        <property type="protein sequence ID" value="VDN53085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN68"/>
    <dbReference type="STRING" id="318479.A0A0N4UN68"/>
    <dbReference type="WBParaSite" id="DME_0000933601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000933601-mRNA-1"/>
        <property type="gene ID" value="DME_0000933601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000933601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15001" checksum="BC8247F7412881EF" modified="2015-12-09" version="1">MKATESKKNDVECNLQKKQSLKVERRNERERKRVHQVNLGYALLLSKVPGAKDKKLSKVETLRQATRYIHYLQQLLNSGNQVPFIIEYRPKLNLQFSHEPYTQSTSQENQVPVLSQVLRFMDNSWTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNB2</accession>
    <name>A0A0N4UNB2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3098</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000104">
        <property type="protein sequence ID" value="VDN53125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNB2"/>
    <dbReference type="WBParaSite" id="DME_0000938701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000938701-mRNA-1"/>
        <property type="gene ID" value="DME_0000938701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866640at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038839">
        <property type="entry name" value="Attf-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36522">
        <property type="entry name" value="AT HOOK-CONTAINING PROTEIN ATTF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36522:SF1">
        <property type="entry name" value="AT HOOK-CONTAINING PROTEIN ATTF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000938701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25851" checksum="D2BA3B24AF54BFCB" modified="2015-12-09" version="1">SDKKIVAEYANLHGATAAARKFNIPAQVASYYQRKMNSKPPGIFFASFFIHVSSKKLISSFDSCQCFRIYFLKFASIFVNFKQTATNPAHCSGSPGFLRGRGRGRPKLIGDELDAELVDYMVQIKQADPRGHMTASQALAIARSYILDKAPGLLEEHGGQVKLKLTWAMKLVSRITERQKEIELGLPAGALSNMSTGIPPGGNFMADMLSQNFLSQQVSQMMNQAMTGYFKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNC3</accession>
    <name>A0A0N4UNC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3111</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000105">
        <property type="protein sequence ID" value="VDN53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNC3"/>
    <dbReference type="WBParaSite" id="DME_0000940001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000940001-mRNA-1"/>
        <property type="gene ID" value="DME_0000940001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000940001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29532" checksum="557C9FBFE91C57FA" modified="2015-12-09" version="1">MSKSVKIEVSSEKPAFSLISAPSPDNTNQIEQQPKLSTQLYRSIDQEAGPINALPAEKTAKKEERRCNIEISVDVNKITEKTLEFRKEQCNEQIAEKSSKSLATSTAAPSLDCDRLSIPIIHLSSMGSRSSMPKSGRNLNNPEELCSSNKASAKVNTTNIEQQICEETTKKLQNADNLYSPSNDSMKKIQRDYDQVICFQARSKNKEGKPSCEPKFSKTNADQIIVNKTNPGAFKEKKSAELQIDSVKENTSLKEELFNKALSQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UND4</accession>
    <name>A0A0N4UND4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3123</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000106">
        <property type="protein sequence ID" value="VDN53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UND4"/>
    <dbReference type="STRING" id="318479.A0A0N4UND4"/>
    <dbReference type="WBParaSite" id="DME_0000941201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000941201-mRNA-1"/>
        <property type="gene ID" value="DME_0000941201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="5">
        <location>
            <begin position="317"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000941201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="50632" checksum="DAE6A90063F44AD6" modified="2015-12-09" version="1">MGLLTFVSIRSLSATSSNLFRVVARGVESQECAYPIAGKKTVTTDIENAFGGIKSGDHIFVHGIAATPTPLLEVFCEYVKSNDLKKITLHHLHLEGPVPWTAADIKDRIRSNSLFTGGNLRKAVNDGTADFNSTFLHEVPLLFRSGAIKLDAAFIQVSEPDVFGYCSLGTSVDATRAAVTQANHIIAMINRNMPRTFGDSVIHESHIDVAIECHDHKLHERPTSGQPSTEEKKIGELIAKNLVDNGATLQMGIGAIPDAALAALTHHKDLGIHTEMFSDGVLDLIKCNAITNSKKTFDNNILYIFIFFLPPIFCIVFFGDVAWVNDPAVIREMPKMTAINSAVEIDLTGQVVSDSVGSRFISGFGGQVDFIRGSAIGDDGLGKPIIALPSVTKKGQSKIVPFINEGGGVVTSRAHVHYVVTENGIAQLWGKNMRQRAYELIKIANPSTQAFLEKAAFNRLKVMPSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNL5</accession>
    <name>A0A0N4UNL5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3184</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000111">
        <property type="protein sequence ID" value="VDN53211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNL5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNL5"/>
    <dbReference type="WBParaSite" id="DME_0000949801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000949801-mRNA-1"/>
        <property type="gene ID" value="DME_0000949801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000949801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33647" checksum="3CA33EA3BD85247F" modified="2015-12-09" version="1">MKDNYVKSNYEEQERLLLNLRRINFAKSVNHTCLCSSADSLEQEIVSCLLCLAKFHVSCVQRTINVAKLLDDYYLCVRCVRGRRPFLDNLLILCANAPLSIERKLSMHVVEYTRSVYKEGATVLSTLSSIDQKSRKDATRRFTSGLVAILSSEAIDCSLWPTFVAELSKIWPVSERQRNMHKKIRSLAENSTPFAVLFYKDNKKVNHNFVRVTRPCRKRKCKSKDDESCAAEICLHPNDDEIHWIQCESGCFRWYHCICVGQKINPLNRISSYCCYRCSPNENAAKHYRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPX2</accession>
    <name>A0A0N4UPX2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rad60-SLD_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3578</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000152">
        <property type="protein sequence ID" value="VDN53605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPX2"/>
    <dbReference type="STRING" id="318479.A0A0N4UPX2"/>
    <dbReference type="WBParaSite" id="DME_0001003401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001003401-mRNA-1"/>
        <property type="gene ID" value="DME_0001003401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001003401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16147" checksum="6CA0F5C834B5D102" modified="2015-12-09" version="1">QKIRDNSNLLKNSYFRNFHIINVLKFQVNLRLILVSGKTKEFVFALRTSASEITQYIFDNWPREWDEEKVESSSLLKLIYHGRFLHGSVTLNALSLPSGKTTVMHLVTRENLPEPNSNGLLFAIRFSAYQENLRVMSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ77</accession>
    <name>A0A0N4UQ77_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MICOS complex subunit MIC13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3667</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000165">
        <property type="protein sequence ID" value="VDN53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ77"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ77"/>
    <dbReference type="WBParaSite" id="DME_0001015101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001015101-mRNA-1"/>
        <property type="gene ID" value="DME_0001015101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5948578at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041159744" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001015101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6742" checksum="FAB9D46817EE515A" modified="2015-12-09" version="1">MAILLKLIRVGAKVGVVVFAVKVSLDNDIWSLSTEKGANLCEQLKERIIPGTIVYPQKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ91</accession>
    <name>A0A0N4UQ91_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3682</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000167">
        <property type="protein sequence ID" value="VDN53709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ91"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ91"/>
    <dbReference type="WBParaSite" id="DME_0001016601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001016601-mRNA-1"/>
        <property type="gene ID" value="DME_0001016601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000145">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF93">
        <property type="entry name" value="GALECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="177"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001016601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36360" checksum="2E111A17729D0068" modified="2015-12-09" version="1">MAASNDNKIFTLPYRSKLTEKIEPGQTLMIKGRPSDDAKRFAINLHRDTPDFSGNDVPLHINIRFDENKIVFNSFTKGAWGKEERQKNPLKKKFPFDIRIRAHDNKFVIYVDRKEVKEFEHRVPLQWVTHLSIEGDAQINHVQWGGKYYVSNSSFSLYFLRSFEDQKNGDNRPVPYESGIAGDGLTPGKALLIYGIPEKKAKRFNLNLLKKNGDIALHLNPRFDEKARTKKFICACGKAGNIIRNSLLSGQWGKEEYEGMNPFARASIFDLELKNEQHAFQILVNGKHFASYAHRTDPNEIVGLQIQGDVEITGIQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR06</accession>
    <name>A0A0N4UR06_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3930</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01000221">
        <property type="protein sequence ID" value="VDN53957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR06"/>
    <dbReference type="STRING" id="318479.A0A0N4UR06"/>
    <dbReference type="WBParaSite" id="DME_0001047201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047201-mRNA-1"/>
        <property type="gene ID" value="DME_0001047201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862363at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF107">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15310" checksum="C9DFB11030D0B5F6" modified="2015-12-09" version="1">MVMCSFSSTLYSFVPYGCYCGFGGYGTPMDEVDKCCQTHDNCYGDALAKCYNITSLLYLWPYSWSCPKTAEGAVQTKTGNSPRCKNTLWNPCGQALCECDQKIVECWANVSTTPPSERLKCNEMETTTVLPNMPSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URG0</accession>
    <name>A0A0N4URG0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4061</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000265">
        <property type="protein sequence ID" value="VDN54088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URG0"/>
    <dbReference type="STRING" id="318479.A0A0N4URG0"/>
    <dbReference type="WBParaSite" id="DME_0001064001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001064001-mRNA-1"/>
        <property type="gene ID" value="DME_0001064001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867083at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001064001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15518" checksum="5F5F2B5D01C8192C" modified="2015-12-09" version="1">MLVQVPGQPAGGGVPGQAQAANVQCPSPLAHACRNNNEAFCTAVFDLLDLQANANPMTTYKVKESCQNANLKQEAIRTCPRSCAFCCLTPQYNCTNATTRRSPIPICSDDRANCAQVQQYCTVELFAGALREQFRRTDHIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URI0</accession>
    <name>A0A0N4URI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4076</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000275">
        <property type="protein sequence ID" value="VDN54103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URI0"/>
    <dbReference type="WBParaSite" id="DME_0001066201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001066201-mRNA-1"/>
        <property type="gene ID" value="DME_0001066201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10450017at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001066201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8716" checksum="241BDA9BC3D6D30B" modified="2015-12-09" version="1">MHTPTRSPASKLSFTIHCPMNDEVPVEGNCAASIKRKLHICFAVCITKKSVRENYDPVIDCMNINDPEQLDPCIGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URL0</accession>
    <name>A0A0N4URL0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS4103</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000294">
        <property type="protein sequence ID" value="VDN54130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URL0"/>
    <dbReference type="STRING" id="318479.A0A0N4URL0"/>
    <dbReference type="WBParaSite" id="DME_0001069201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001069201-mRNA-1"/>
        <property type="gene ID" value="DME_0001069201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN54130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0001069201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30342" checksum="FBE1D816CD58162B" modified="2015-12-09" version="1">MLVMIPSIARVFFFEMTKSTWFANLVLSFLGGFISYRIILEYIPIFIQRKLYGRDRCKVNVEPVAEPVGVVSAAVYLIIMFLFIPFLFYEWASNESPFPHEKLLIFMSAIVGICCAILLGFADDMLDLRWRHKLLFPTLSSLPLLLVYYATGSSTTIIVPSIVRKIIPVSENIDIGFLYYLYMGIMIVFCTNAINILAGINGLEAGQALIIAISIALFNIIQLIRLETEALYHSLSLYFLLPFISTNIPLIYWNWYAFCHFFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2R5</accession>
    <name>A0A158Q2R5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protocadherin Fat 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5034</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2R5"/>
    <dbReference type="STRING" id="318479.A0A158Q2R5"/>
    <dbReference type="WBParaSite" id="DME_0000067401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000067401-mRNA-1"/>
        <property type="gene ID" value="DME_0000067401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000094">
        <property type="entry name" value="protocadherin gamma-C4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF133">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1931"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="85"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="186"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="284"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="389"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="491"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="781"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="887"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1314"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1513"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1613"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1721"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1822"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2017"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2025"/>
            <end position="2044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000067401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2132" mass="239887" checksum="84B4231B16500295" modified="2016-06-08" version="1">MISIQVFAKNNCGSNNRLRYSIQDQPLIRNFFNIDDQTGTICLGANLDFETTAKYQFVIEASDFGNHALVNIHVEDVNDNYPVFYPSIYNVTVREDIAVGSLILIVYAKDADKGIYGQIHYRIIAGNDGTFKLEPRTGEMLVQNKVSKKRYDIVVQASDGGGLTSEKVATVHISVTKASIPIPQFTSLLYKFEVPEDLLPGISIGQVETAGPYKIKYNIYSGDPDHFFMINSLDGKIIVSRYLDADKWQSILLNVQAFTDRGESSYAQVLIDLIDVNDNDPVFPITKIEAYVLENQPTHIPFFALQAKDKDHGKNGEIHYSLVQSEPHCPISVLPITGEMILTSNLDYEDVTRYNLIVKARDQGVPPRHNNVTVILNVLDVNDNFPEFEHNFYEVEVPEDASLMTQVIAFKAKDLDRDANGKISFHLSDENTDFGIHASSGIMYVKSPLDREFKSDYHLTVVASDHGQPRLSSNATIYIKILDINDNSPNCSTAQPVVLTDDYAVGIPFGAIKIIDSDEGINGTVRYRVQNDPDFEVSADGKISRKHLVTHSGKDYYLSVIAYDNFGNAGSRSSICQIRIIYQSIQSKVKLIEPFERVITLSRHCSNNCFLMKLNASNVVKWEIETNEISRFFKIIRNSLWTSANFEQKYFKTNRILSVSAHDSENRKKQIIFTIRPIFSSPTINSSTIYLKFPINTAVGTVLKTIDSEKKGTIWNLENEIEQFYLDERTSELYLVSSFANSNQLFYTLSLTRMVVPDYATERFTIHIEIEVGNFRRPKFKGCPMKITIDENISIGSKIAKVKARYAHDGNDGPFLYKINDPSRLFAIDQESGEISTRKVIKWNSMKKSIFLAVEAENRQIESMPSKISTCALFIDINDINNHSPQFKSSSSVTIDEEWSNSEILQYIVVKDDDDGNNVTYSIVDGDKDSFVLNATTGEMRLLHSLTSNSSIIIQASDNGNVPRISEQNFTVYLNPTHQLWKFFIRPIYSFSITFERPHLQLISDKAGGIEPFNISVNGELQLSAVLTNDFYSLIVELKMAKGNMNAPRIMPSSCGNISIYENISTNQLIHVFAIDYDEDENAGNENNAFSINSTSGIISCEKLDREQKSEYFLVITAEDKGNPIKADTCTIRIFVLDENDNAPVFKKDTPEYLEIDDNTKIGGIIARISATDVDADKNDIGASTVLHSTIAVPLIVRRSLITDQLYESPPSFVSGKYFGVVEEGRPEGEFVLQVYTTGHLSGNAPVAYSIVSGNIDNAFGIDSEGKITTMQELDREIESQYSLGITANGSYKQSPETKVYIRVLNTNDNPPLIPTMRPRKISELAPIGSLVATIRATDVDIDSKLEYSLINNYEIFEINRYSGQIYLLQKLDYEAIKNYSLEIQVSDGDNISKSTLVVEILDENDNRPKFDKDFYDVVLPHGNNSALIAKIHAVDPDSGPRGEIYYNFSTPNNIFHIDENTGAIKLLSKRAINNIYFLKVQAFDKGQPSLNRAVPLKISFIDGLSKIESIVEKKSYSFSIREDLEINLPFGQISVKQMTNFKVNFRILELEARNIFRIDHFGQLSLKKPIDREEKSEYNFTIEILSNTFSLNDSAIVFIEVTDVNDNPPVFLSRDIRITINEDIKPGEILTRIIASDRDSGENGELSYYILSGNDHQIFKLDATSGVLIFTKWNDEVIEDDHEELIIIASDNGRISKWNWTRIIVVVDNDIFSATAPFFVVPQYQKSVPENQLADEVILKIRASNRIGRSEMDWKYRLRDNDEIFVCNETTGDILIRKQFDYENRSSYSFSLIVSDNTSRSAVVPVEIFVLGIDEFPPVFMKSSYIFEAPITTKVGQRIGVLMATDQDSGLDGIIRYAIEGDAMRYLTIDSDTGQLILKKELAEIAKEKNLTVDEFHIVASSGVSQHSRVKVTVKFVESTAYLSPSKSPYTIMLMLLSLLILLSILIMFVIKMWMRMRSHTAIKKQIYSVSKGNTAVMADLSRYSPSFQYDKQRIPLPKIPVTKIASSSSSSSISRYSAGSGSTQPKFNGQLLNGRSAPQSMPDSGIDPDDVSITSSVTDYLTQIGVTHNTIFDQRNGSNRSRLMHGKNTFYDSALNDLIYAKIDQFKFSSVPSFEPIKDLLSRKTQANVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q361</accession>
    <name>A0A158Q361_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6085</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q361"/>
    <dbReference type="STRING" id="318479.A0A158Q361"/>
    <dbReference type="WBParaSite" id="DME_0000172501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000172501-mRNA-1"/>
        <property type="gene ID" value="DME_0000172501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877808at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090535">
        <property type="term" value="C:WICH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140801">
        <property type="term" value="F:histone H2AXY142 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047174">
        <property type="entry name" value="BAZ1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="4">
        <location>
            <begin position="369"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="545"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000172501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="857" mass="98080" checksum="9FEE0522EFFA68F5" modified="2016-06-08" version="1">MRKICAEQLGSGNKKDDDGGVALEIFKSRSVNLDRKNNKCIIEDLKSTKNVLKPRAYNSAVIVQVLKSGGTTKKIKIDDQKQVSVCNRIHGQKAIYTPIFIRTKQIPQKSRMEENLCPCTSYVDDKEKESMLLPVESPRNKETQNVCWPLPKPEIVDSDDKFLQALKVCSKDFQQNTVKKRSKKEIEITVKPFDKIWIVENKNMESNWIQKTMACISGSLSNAPISPNVMKNQAQFFITFALLNNDRVNSIISRLNKALFSCKPHFFQKECAAMAKTFSLAHINSISNELLRFAILREYDKGAMTKFVSLEKEAYCKKNVFPLKGDVDYKIMEKKLNLLLTMKPDDLLIHDAESLPILNDVKLPETFSYNQFAAILMLTEFLYTFRFFLQTECIPSADELMNALHDGRKGYFGIVGHILISLVKSILCDVHKQKIIVCGVNIQSIPVTLSTVWEIMKAIFLSRNQHEITFDSVNIADSCDASLSSGSDSSITNGDNAETSLDSEITKEFFELSVDSQLDNLEKLMNMIFGTKAFADYMFSFHSDINQTKQTIKQLETKISDLTAVLKKKEEAPIVKYFFRCPALENKEIESLKEKIENVKCELQEKNNKLKCWWASKALPFRKMEETDFNECNSNSECNSSDVYEELLLNNDMSTFSMKHELMLPMDNGSYTWYRITDESTFERLLVSLCKNGLRESKLYVNIKKNLSDICNSWNVGSSNLYIKRIELQTVNEKDLLKESFIDLIIRLKNAKFLKVEVYDILREKMVVAETIDCIKSALLTLAESLLSRKYDMRLSFPKLRWKNYVEEKGSISRLAILLSVLDNSINWKNREQVGNTSFKGELCVDNGENKAADFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Y6</accession>
    <name>A0A158Q3Y6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7565</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Y6"/>
    <dbReference type="STRING" id="318479.A0A158Q3Y6"/>
    <dbReference type="WBParaSite" id="DME_0000356001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000356001-mRNA-1"/>
        <property type="gene ID" value="DME_0000356001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2570713at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000356001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20324" checksum="F6BF56DEEAF5E87F" modified="2016-06-08" version="1">MVQYQNYFKEFVKYSSRAKHNTKIMQKALELTLSIPQRATDLIYINNIEEYPGDVKRLGRLYRHDVFLLWENDEEPIDCYAFLFKNKLLLTKKDTRKDPPIYKYYSTIRLDRYAVGSVKNEEDTIEMKPHEYDLPTYRIRAKDIATMEIVRQAWLKNIQEMKDDLGKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q462</accession>
    <name>A0A158Q462_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS459</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q462"/>
    <dbReference type="STRING" id="318479.A0A158Q462"/>
    <dbReference type="WBParaSite" id="DME_0000409501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000409501-mRNA-1"/>
        <property type="gene ID" value="DME_0000409501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="698"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000409501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1621" mass="187388" checksum="CD52D267243DE02B" modified="2016-06-08" version="1">MSDMSESDVVQEGIDSLSILSSGIDLDVEECSDVLTVDFTDDSTDIINVLYNFHAKHESIIAEFADVEIFLISIDALLIELTAHDYLNWTLGGQTIVIANQIDIFLNQLNELGGKFKLIWFTDLLTIYRKYTVLNFLRSFVAAYLLQSRWSSEIEEFDNPRDQTWSSYLRELTPSFLMTDIGMPSKAIVPEEEPNYRLMLASIVLQTLASAVPVVYLSGLIKNFCSIICHRIEPVIVDFKGWDVFLAKVWSNKPKRLKRSLDLSSMENKAYFWSKIIRECKDSGKFDNKFDVLALSLLISTLVIEKRGKDRIYLPEVDFPRRGMDHIAHRRILLTVCSQYLDTIDFKNKPLKFSLADLWDGRFIINIFDHINAGKKVSPYRIQNELVVFHELSALEVSLEVDMNDQLFDAVPVNDALLNHVMLLETDCALLHNFLPKYKEAIGKFNRIEEPEVFEQFRKVAGWRFHPIQPLYAKPLEKIDDDSFNKDRQRLYPLIYIYFVIFFVYLGVNIGAKGKKEPAKSKKDLILEANQRKKNEKQIDSEKQMISYALMQGNDAAFILEKLMGKLELDQSRALCTYELITRLSRDINAIDGPAFIEQRRKKAVPIKKSKFLLKVILFSSHFLFVRLAFQVTDLWKSLGFDLTGKPANYSQERLSLNINMIYYQLQYGGELIDIESDPQKDERVTGFNPDYWQRKMLDAVDKNNSAVIIAPTSAGKTFVSYYCIEKILRQSDDDVVVYLSPSKALINQVCGSVYARFRNKSLTGGKTLFGTLQNNFYENPLNCQVLVTVPELLEDLLLSTDPVIQRVCARIKYIIFDEVHCVSASPEAHIWEHLLLLCRSPFLALSATIGNAKQLHEWLSEVERDKTPKNVRQVRTDLHSFSKFQVELIIYEERYSELELYLQRIAPVDQTTVENYNSIEHFMPYGIYKPLKLSMFGIPADQQLTARQILELYHALSEVDPAVKEKFEPCKFFNYKVGGEKVWLTRANIRLLEKSLKNVFLDWLEKDIDKLNKVLQNLSHEINDELDYRSRPFAKRNIARKTIAPLVLELRDKDQLPAICFNDDRRICEEMAICLFQFLEEKQKEYEESEEYRTKYAIKDEEKLLKFARRKRDINKKKRKLKGKKKEFDSNDIDSDPREDLEELRLAGEDQEDLLTQQRFLREQALEKLRGRNRDEDLFLKMKKRLLKGKVRETSLLLLRLFERGIGFHHQGLNTRERGATEILFRSGYLGIIFSTSTLALGINTPCKTAIFGIDTPHLTPLLFRQMSGRAGRRGYDHSGNVVFMSIPTAKLRRLLTASLSTLRGNLPLTTSFLLRLFIYVHQKEEEGISIYLSFGSNYFFNLFILMKKILQIALTFLNHSFILYTLPEKAEALKRQLNLFVLFSVNLLRRLSLLNKMGEPNGLAHIVCHLSANEPGNLIFAHLLQNGLFHEICKNYKHSKPLLKSKLILILAHIFTKKRLPISWNPDKKKLQEKIGDAEVCLTPMPDECRKFIEEYNEEVEQLFKAFMQLVGTKDFSELHETRNSLQGSVFSLTGNSDSSVSLCTSYIVPPYHEDLSIDMGLIPACPLNPVDHRGNKVNLNRISEALFTVGRSKDPFVEVMKELSEEYDQIMKQVFDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4E1</accession>
    <name>A0A158Q4E1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8534</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4E1"/>
    <dbReference type="STRING" id="318479.A0A158Q4E1"/>
    <dbReference type="WBParaSite" id="DME_0000465101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465101-mRNA-1"/>
        <property type="gene ID" value="DME_0000465101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="6">
        <location>
            <begin position="145"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="5">
        <location>
            <begin position="338"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="671" mass="75530" checksum="319602DFB51BC13D" modified="2016-06-08" version="1">MIVMSLLMTLARYYLRNITEKCYDCNIIDEAIAAVSTSFGGVTCAFLYSTSKTPDVSKMSEKELELYKLYRPERELPKIRGTDLLKDPRLNKGMAFSLKERQYLGLHGLLPPAFMTEEQQVYRVISKLRAQPNDLAKYIQLDGLQDRNEKLFYRVICEHVKELMPIVYTPTVGLACQNFGYIYRKPKGIYVTINDDSISKIHHILSNWPENDVRAIVVTDGERILGLGDLGAYGIGIPVGKLALYVALGGVQPKWCLPVLLDVGTNNEKLLKDPFYIGLRRQRVRGEAYVKFVDNFMKAVTKKFGQNTLVQFEDFANVNAYPFLDRYRNKYTVFNDDIQGTAAVCLAGLLSSVRSVNRLLSQEKIVFLGAGAASTGIADLIVMQMESEGLSKEEAQNRIFLMDSKGLITKTRSEPIKEMHNRFAKNIPPTKSLLEVIETIQPTAIIGASTIKGAFTEEIIRTMAKINERPIIFSLSNPTNKSECTAEEAYRFTDGRVLFASGSPFPNVELNGKIFKPGQGNNSYIFPGVALGIILFKVRHVGDDIFLLAARASFICFFHSLVLFANAEILTKYKVASCVSDHDYSVGRIFPHLKRVREISIQIAVEMAKYCYKNGTADLYPQPEDLEQFVRAQIYSTSYDEMINVTYDWPANDMKHGFPVPPTSNDSSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4K8</accession>
    <name>A0A158Q4K8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8899</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4K8"/>
    <dbReference type="STRING" id="318479.A0A158Q4K8"/>
    <dbReference type="WBParaSite" id="DME_0000510001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000510001-mRNA-1"/>
        <property type="gene ID" value="DME_0000510001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF550">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_44, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000510001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35428" checksum="335AD8AA9BDE70CA" modified="2016-06-08" version="1">MSGETMKVRHRVSNEIFLMKNVDRESYWAEAFLCELEHLQLLKNHSNIIRLIEAFNFGRLSYMVVEHFPSNLWEFILKNEIPKSYVQSFTYQICRGVSHCHEKSIMLRNIMPSNIFVTSNLWIKIGDLSLSKTAKNSRVFSSIKVGALEYRAPELLFAEIIGKHYCNYTMAIDVWSVGVSFLTIATRKLSLRGSDAKTMFNCIIEALGTPTSREWQSMDPNYTEHRKEIEEIAPEIRRSGLWKALCSYLECEEIYFAKEFLRYNPKLRISIFATLNHKYFDENNFNKLALPTGQWDGTKAVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q506</accession>
    <name>A0A158Q506_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HTR5B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1075</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q506"/>
    <dbReference type="STRING" id="318479.A0A158Q506"/>
    <dbReference type="WBParaSite" id="DME_0000617801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000617801-mRNA-1"/>
        <property type="gene ID" value="DME_0000617801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="6">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="5">
        <location>
            <begin position="270"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="7">
        <location>
            <begin position="1345"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="1575"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000617801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1605" mass="181296" checksum="955794B614B51448" modified="2016-06-08" version="1">GLIVAIFECAVALPTSNGARNEISGSLFDIGTSQPSVFFSAAHAFLIQQNKLSGHNRAFILSIINKILESSHVSENLDEQQALLIINLVTQEITISKDQEEAWPQAASDVLVTLAKRKTLVNHVMDAVLQKFPPGLSVPPHRYIVLSMASIAEHNAIGFVPFLTDILSRSIPLLQNIKTDSHRYAWAHAFRSFCESLREYTTTFIIDKSQAINGRNLKVSKYGSEFAPSDYTDQMEMVYDSVFCWLSSKDPKVRAETANCVGELCLVITQKRLNEEIRKLIPMLLSLCRRATIDQHLITQGICVLLEAACVDDSCSLEPYLEDILNTLFPHVCVFNEEAINSNFTMRNQNEAFRCFHVAASRFADKIVYYLLHKMQSNQDPCKLGAINLMRHLLNSAGPYMEDKRALVILGLKPILQAGISDSLSIKVKKALCQLCIALADHGYIDAQGGCAVIEFLVKNAVAVEEISKKVLSDNSLGLSLRTQCGQALQTIANTCSFAHKLLWPYLFVYICVEAYTPVITDIIKCLRLLAERMVDEGEKLDFVTGFDEANVANNLQVFCRLLVCLTNAPLNSSLTKRAYEALRLLRAAASWFHSSLESVVEEYYDKLKFAIDGLSTVGEEAVPSSQLSPKLRSRFIVEWHTQVLNFLDACVVSVSEGEWRCCLASTMAKHFNLYINFHDEKAFLMRCIGQVLARITNAAFVNAHLMLMFRETNHSYLVERVGCAQAVGYCSVTHIDLVIAELERAIKWDYMKKRAKVFGFIQDMIPYKNYSDSEMANLHATIMLCYGFVVFHCPIEVVVQQVENKVLQSLRRHLENPQLETVERESLLQTIYLIAVSVHPSYLNADYHLEILSEFLTHIKVHIPIFILDLFIFIILFFKFRKFSRYGRWCTKLCERHVEIYIKRIKTMIQLSLGLLSLSLFYFKINLYDLIIIDFFQLFQPYYSSIADHERMRSIEATLLVLNIYFDAATDFSLERANEFTAMASLLAFLVPRITDSLCYVRYNALKVVHWTFRLSFVLKGVARETPDPSLFDYDTFMQENLGHEEKLDNLISRKIIKFMANIVEARLPSSLVNNYMLYLFNMLNDRQNQVGSAAALLLSNIIKSRGDTLRNEAKMLMDVMLTKLSEVHSSAQVHDELQNAFLELANHQLHPCIDVMLSHPLPYSINVVEAWHTLVSESLLFPLITEYLIELMVSVSYDFVDIGSGTSTKIVRAGVCSLAAGIIELVKNGQPENEFSKRIPQIIATLLIYLATVIDTQYPLVQQEQKDGSKSPLIITPELRRVSSSPATLVSQALLTLFARTRDEKIVAKMNSERALIYNIYIYIYILYVLYVIICFIKITAIFQFAIRGFGDLSECSPNVLEKYSSCAMKAIINGLDYSGDRRDEVATEAVKALNKLSSCVETNRLQGILSNVLLKLRPCFEKENTALRIASFSLFGELGIRVGDCDIFKEQLIINSVSLLLHLNDDEDDVKLICVRCLMLVGPLFHSTGISSVIEKTLNAEKICANYPLFLKEFSQVLASSFPDRVNYFALNLNNYFKSTSSKIRSNAACMTGFLLGCLSPELQTTISKELIFSGLMSLLKDQSIDVRLSTARAISFLQNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q536</accession>
    <name>A0A158Q536_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PKS_AT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9474</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q536"/>
    <dbReference type="STRING" id="318479.A0A158Q536"/>
    <dbReference type="WBParaSite" id="DME_0000636301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000636301-mRNA-1"/>
        <property type="gene ID" value="DME_0000636301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847021at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="465"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000636301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="773" mass="87368" checksum="E98FD4B745C6B822" modified="2016-06-08" version="1">MIHTSDEKLFQILVQAAGDSQQRPQYYIGGNAALMAEKIASSFPRTTAYLVGPIGPRSQALLHPSIVRTNSTRIIKDEIHIIMEYKQGEILGEYVAPASSRFITSHDQYSGSSVVIEMFFKAISQFQPDLIILTGVHLIQTQNKEMRSEKLRLIKRNLLQLPSNIPIHLELGSIGHADYVAEVLKKIVPNVDSLGINEQELAFFSHIANGPYTDLYPVSPGAVHVHKFVAHLNITINYFDYYMNSKKKNFHVYRGTDWSNLAAGLAAGARTAAYSCNAARDINTDNLELRTSLTHVLDREVGKMYNFEPHKPIASWMRKDVVFIYTPVLVCKFPSRTVGIDDAISTSGLLFSQFHRFSTWMKRAVPPLLSTVRGIRRIRSKKFLCPDPIETLKKPTNRPVKWIEDATTYSDIHNLMTDPSSIPYSRKDMERLMHSTQEKMKKETKKKKKGINFGHIPISEQVVVMFPGQGSQYTGMGKKVIDCRKADEIYERASEILQYDLKQICIEGPKTKLDQTIYCQPAMLVTCLAAWEKFKQSNEWVVDKLTHTAGFSVGEIASLVLAGVISFEDAVKLVKIRAEAMNQCSQRISSGMLTIRTSAISRLSEAMKDAKLSAVEKNELAICEISNYLFCHVKVIGASQKCMDYLIQNKDKYSFQVVKKLAVSGAFHTTLMKEAAEPLNAALKDITINPPCINIFSNYTGELFHDSPISIKASIVKQIYNSVKWEQIQQHLFRLHRNHQYPLYMEVGPGRQLGAMFYNISKRVYAHYESFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5K7</accession>
    <name>A0A158Q5K7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS1903</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5K7"/>
    <dbReference type="STRING" id="318479.A0A158Q5K7"/>
    <dbReference type="WBParaSite" id="DME_0000763601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000763601-mRNA-1"/>
        <property type="gene ID" value="DME_0000763601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274:SF6">
        <property type="entry name" value="TYR_PHOSPHATASE_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN51930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000763601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21710" checksum="C999D14EE3920BAE" modified="2016-06-08" version="1">MLTELAFYPSLGYNLLRNYLQPSSWKWYTRIDDIVIIGALPFKSMVEELEKENIGGVVCCTEEFETNAAWGAMNEEDWKKHDVEFYALPMRDFNGSASRNDIDHAVKFVDNIGNRGKSVYVHCKAGRTRSALLTTCYLMRKNDWLPNVAFEYLKSKRPHVLLKEAQWRSANEYRRFLDHTKQKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5T3</accession>
    <name>A0A158Q5T3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF384 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2267</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5T3"/>
    <dbReference type="STRING" id="318479.A0A158Q5T3"/>
    <dbReference type="WBParaSite" id="DME_0000819101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000819101-mRNA-1"/>
        <property type="gene ID" value="DME_0000819101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000819101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19052" checksum="E1F9E44254793A24" modified="2016-06-08" version="1">MTLATVPNHETILNNDEYFCGIIEPLMDLSYQFSDNEMEKLPLQLQYYDRTRISDFSLINKLLDIIYKLISTGTGLDCLSRKGIYAVLRELDKSLNHLSQKNILFNEGNFKEYGSKDDWQEERIGNEICKRTVQNENKMKLIDENSDLLHLLIGILINSSENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PJT3</accession>
    <name>A0A3P7PJT3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM120 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PJT3"/>
    <dbReference type="OrthoDB" id="2015098at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 120 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="250" mass="29226" checksum="D379A197FAE6089C" modified="2019-02-13" version="1">MIDTISRFYLSLILGSNLNLSLLNRDNRYRYKQEYEKFKVTVSYAALFFFTLSIFDMICSFLMVWYYCTLTIREAILSKNGSKIKGWWKIHHYVSCVICAFVVTWKDGLCYEAYRNQFLIFNIYIALVQLLQCRYQNGCLRRLHALGQRHSMDITVEGFSSWMFKGLTFLIPFLVVAYAFQFYNAYTIFVIYRTMDCSGQWQVPALAIAFLFVACANTFTLIAVLINKWKKRSSYSALLELIKSGAPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNA2</accession>
    <name>A0A3P7PNA2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNA2"/>
    <dbReference type="STRING" id="318479.A0A3P7PNA2"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF74">
        <property type="entry name" value="PROTEIN UNC-33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="113"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="280" mass="31147" checksum="0F9B74FF780D45F9" modified="2019-02-13" version="1">MFLKNLQVSPSIEVESGVKIIDGTGKLLMPAGIDVHTQFNASDSVDDFSVGSKAALAGGTATIIDVIIPTTNESLLAAFDRYYKLAESISLCNFACYIIIYIFFSSYLCTCVSDHHATSNRSSGNYKMSSKPAVEERMSVLWEKTVHVGKMDPMRFVAVTSSNAAKIFNLYPRKGRIAVGADADIVLWDPARMRKFNCQGQQSKSPTCFFDSFTASASPVLTICGGRLAYHENKVSFSPYSLEKLKRARKIFLINSGFLLIGIFFWLQFFFLKKIIENRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPX1</accession>
    <name>A0A3P7PPX1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPX1"/>
    <dbReference type="OrthoDB" id="5856685at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="165" mass="18977" checksum="C6D0D86B2A62F889" modified="2019-02-13" version="1">MQGKEYTATRTVKAVLKNITFGGKKTNPVWTCFEDLRIRGLSGVRCRYCLWITNDRSPTTLKFHLKRKHDTGLGGIWSNVEEKIYLSPSNISFPRMKLKPEDHALSHTPSIFMSASFSIYNDIFQNSLFTHPPIYKSSLSTHPSYIFITLFPRNEIFSSPIPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PWR1</accession>
    <name>A0A3P7PWR1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PWR1"/>
    <dbReference type="STRING" id="318479.A0A3P7PWR1"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018314663" description="Fe2OG dioxygenase domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="85"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="247" mass="29002" checksum="8E22EA577BCEC883" modified="2019-02-13" version="1">MSHITVFPSFILFIYILQAPPTIRYIPNFITIEEEQLFLSEIYAAPKPKWQQLSHRRLQNWGGVWISFAIDKLMSLADTFQPENRPNHILINEYQPGQGIMAHTDGPAFYPLVATISLGSDLLIDYYHPLNTEVTISKGSRYVGSMFLQRRSLVLLSDEAYSHYLHGIDDRLVDQITDKVFNRNIAGLELGREIKRELRYSCFQLRNIHRLSSFEIIVKEVFKTEDFFFNFLFFKIIFFCFLFLDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q6Q2</accession>
    <name>A0A3P7Q6Q2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q6Q2"/>
    <dbReference type="OrthoDB" id="5862467at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="161" mass="19218" checksum="0CAAB8328C1D462E" modified="2019-02-13" version="1">MRDEFVTTCMRLSYQSEKSLIEFCQAYENICFDVPMEDSINRKIPSFVSYFRITTTTTENPHDYILFCREFKHRFLYVCPDPLRFGQKAIFCPLYAERCDVALPDRSIIPTRPHNEHKIVIASLCSRYKMFANNYCRNPFFQGNYKSACEKYFQFCTSNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QSK2</accession>
    <name>A0A3P7QSK2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QSK2"/>
    <dbReference type="STRING" id="318479.A0A3P7QSK2"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72865" checksum="FF490BCF633F1A96" modified="2019-02-13" version="1">MKRSLSFSVYVKKKGMQLDIDWNALEQQKSFGFDLADIAITFSSDNKKAFIVSHSDVIGIDIERGSRQQIFRHSESVVFTYFEDTAKLITYTANGLRYEWNTNYGVELCRKDLNVKNLFSCYHCNNSVIVLDKNDFHELKIKQILLNDFSVKVLLKTPPHNIRRSQVALADDYLIVADGLYIIKYCYTGGVQKFKFTGKITFMDPSLVEFVNVVAKNGLVAAALSFGRVFVWFVVRNKEIGTYFQSIHWHKSAPCLVLTPSGSLVTGGGEGVVNKYKLSKTKSGEKALFLPRLQAPVSKLSISNDGSILAVALVDNSVHFVILSTMTVLSSAPTILCSPQGSLIPLTIDPLFPEYLVYSARPGVIQWFDPTTLLTVAVADISMQNPIDGSNPSYPEPFGFIDVCAIALSKKMVVTAECSVNFPIPHNRIQFWRRKEEIGALALDYSYTCGNIQIVIIRGSLDDDLFFIADAKGCFSYWKRMDNEPAKWYHGSKMHWMQAEIICASQICNSFISLIHKLSCGNSVLAVWDVIHHQRKARPVYIYEGDSTLVASEWCAAPNSHLLLIVTKAFIATMDSYSFALIWVVIEADLDIGITSHFSFSSSPQGELTIFDAKSSKVFKQIKLNGLPKNVVAICKDDDFKIVAVFEKVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SPS7</accession>
    <name>A0A3P7SPS7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SPS7"/>
    <dbReference type="STRING" id="318479.A0A3P7SPS7"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF9">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="138" mass="15629" checksum="9734985E7BEDFB49" modified="2019-02-13" version="1">MSHFPVAAVAKKQTKKDIKSQQSKFNEDEATNLLEWIASLIKEDFNTSGERSNFANTLKDGQILCKLLNSVKPGTVKKIMKPTSNFNCMENINQFCMAVRALGVKDEETFQSVDLFEERDLFSVCVTLQSFARMVSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SU04</accession>
    <name>A0A3P7SU04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SU04"/>
    <dbReference type="STRING" id="318479.A0A3P7SU04"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="270" mass="29143" checksum="631D525EEA482587" modified="2019-02-13" version="1">MIEYVLSKSDNSKSDNFFKLRTFLSSFIGCLCIVACGIVPAFILPTESNVFRQTEAGQRKLNLLLSFAVGSLLGDVFLHLLPEAWADSKADKFATGIWILIGLLSCFIIEKCCTTTEDSQRKACAIVNLIANFIDNFTHGLAVGGSFVISHKLGILTTFAIIIHELPHEISDFAILLRGNFGKWTAIKAQLVTATGGIFGASVALFFHVGSGMDGIVQHILPFTAGGFLNIALAQILPELLQESNPKESMLQLLLLFGGVAVMGVLGQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T0L8</accession>
    <name>A0A3P7T0L8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T0L8"/>
    <dbReference type="STRING" id="318479.A0A3P7T0L8"/>
    <dbReference type="OrthoDB" id="5984709at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437:SF1">
        <property type="entry name" value="PROTEIN SREK1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437">
        <property type="entry name" value="SREK1IP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13457" checksum="83B69A61A5F08F96" modified="2019-02-13" version="1">MQFHKFNKNLFRNLEGKAINPLKPPISGACRKCGFVGHLAFQCHNFSLVDKNFLDLSSTSSESEYETPLKNPEKKSDKKRKKKSKHKKKQKQDKKVKDKDRKRKKLSGLRKQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T2E2</accession>
    <name>A0A3P7T2E2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T2E2"/>
    <dbReference type="STRING" id="318479.A0A3P7T2E2"/>
    <dbReference type="OrthoDB" id="10065496at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF119">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="1">
        <location>
            <begin position="522"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="803" mass="92345" checksum="9255DB1FA1D75948" modified="2019-02-13" version="1">MSDITYNMIEFPQLKILNAHFTGEHFKIITDFLLKGIAPSEFWFVNAIEKLYINAVGNENSKLDYATMWRWALAQTAQFCIDNRMKTPLGKALQTYIAFERFHDHEAGDIKPEDDILTTAEQWFRVRVLLETLEILEKLMSYARDGSTFAISTISQVSQQFFITNQTSCSSWLSRIYLPMMAVACMNGNYAQVIRLGTFTLRIAERYQSNNDNSKGGITYNTFQKNVGNVISMLRILDLLVRYSEPLSPLINSEMQRTNELVWKEILPQLFARLNHPLITVRNTICTLLERIAIISPHSLCYPAVVGVTEPVEINDDNDEDFNDEQNSFQKNYPTLVANISVFIKEFQRINMLSEERWIFVLSNLDHEINKRVAQIELESTRTFANPHLTNVENAIYIYIYIYIVYVLNQILQIFYVIEDLYERSCGKNYLTADEQQFRDTYGDQIAAALESYEINKSELSKAWLPFKQLLYNFTQGSSKRPSSILQIGDLSPCLSSLFHTKIPLPGQESVDFCDLIFIESINKQVFVLPTKTRPKKLSFIGSDGKEYSFLFKGQEDLHLDERIMQFLCICNLIMTEKRIESPPYSAITYSVTPLGSRSGLIQWVDGATPLFHLYRKWQQRQLNQVGVERPSELFFNRLKIAFKSNVRFFLEFWLRAGSADTWYHVTERFARSAAVMSIIGSILGLGDRHLDNILVNLDSGQLMHIDYNICFDKGRILRVPETVPFRLTGNIVHALGPTQIEVLGTFRLSCEHVLTKLRVNKEVLLRAMDAFIYQPLIDWSCTHDSTFSNTAVGTAVTLAVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0D4</accession>
    <name>A0A0N4U0D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4368</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0D4"/>
    <dbReference type="STRING" id="318479.A0A0N4U0D4"/>
    <dbReference type="WBParaSite" id="DME_0000000801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000000801-mRNA-1"/>
        <property type="gene ID" value="DME_0000000801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF88">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000000801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51762" checksum="6686368F972B2341" modified="2015-12-09" version="1">MDRYTVAEGSMDCEESKFLKIKEKNRKANLKQLFIGVLTQVQKFFNINDAEAGLLQTVFILFFMIFAPFFGFIGDRYNRKRIMAAGIAIWVIAVFASSFVPRNCFWLFLLLRGIIGIGEASYATTAPTIIADIFISVVRGRVLMFFYFAIPIGSGLGYMVGSFLASVFNDWAWGIRLTPILGIICLFLIMYFIDEPQRGQAEKAEGALTATEIEITSYMDDLKALSKIPTFICATIGYTAVIFAVGTLSWWAPTAIQHSYAMQKGLNSTNLLDSREKDRITFVFGVLTMAGGIIGVSLGTALSQMLLQGSLCLQRCQTFRANALICALGSVLGTPFLYLGLHLIEINMTASWTFIFFTVTSLCLNWSINVEMLLDVVTPTRRGTANSWQILISHLLGDASGPYIVGLISDLLRHSASGPAENFRSLITAFYLPNFVLVVSAVFFGLAAVFFIRDKRIFEKQMGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0V8</accession>
    <name>A0A0N4U0V8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4564</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0V8"/>
    <dbReference type="WBParaSite" id="DME_0000020401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000020401-mRNA-1"/>
        <property type="gene ID" value="DME_0000020401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720794" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000020401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="6391" checksum="03C9F5A806BB124F" modified="2015-12-09" version="1">MYLGIVVLLIFSIASSSAFLFGGGGGGGGCCPPPCCPCGCGSGGASGGGGAIAAIPIPIGGGGGRVGGYAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U103</accession>
    <name>A0A0N4U103_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4614</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U103"/>
    <dbReference type="STRING" id="318479.A0A0N4U103"/>
    <dbReference type="WBParaSite" id="DME_0000025401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000025401-mRNA-1"/>
        <property type="gene ID" value="DME_0000025401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000025401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40600" checksum="EADD499E345A47DD" modified="2015-12-09" version="1">MNQESQNGSSEQKYIRPAYNEMTSKDYYFDSYAHFGIHEEMLKDEVRTVTYRNAIYHNKHLFKDKIVMDVGSGTGILSMFAARAGAKKVIAVEFSNMATQSKQIVKDNNLDHIIEVVHCKVEDITELPDGIEQVDVIISEWMGYCLFYESMLNTVIFARDKWLKSCGAMFPDRARLYLCAIEDRQYKDDKINWWDNVYGFNMSSIRRVAITEPLVDVVDQGQVVTNNCLIRDIDLYTVKVEDLSWSQEYSLRIVRNDYVQALVTFFTVEFTKCHKRTGFSTSPESQYTHWKQTVFYLQEALTCKKDEEITGCFSVTPNARNERDLDFKISVNFHGEVCDVVEENVYTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U133</accession>
    <name>A0A0N4U133_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4648</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U133"/>
    <dbReference type="STRING" id="318479.A0A0N4U133"/>
    <dbReference type="WBParaSite" id="DME_0000028801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000028801-mRNA-1"/>
        <property type="gene ID" value="DME_0000028801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF86">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="126"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000028801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="46242" checksum="C1256177E9F06CBD" modified="2015-12-09" version="1">SLDWLVVKKSEKNTSQVLFFRRKIKGIPQEFDTDFYLARWWRAYQGDLQLIRTYMKQLFEHRRLLGYDRIDTEGLRTKLDMACKTFERFSISSFSPQFSGNVCVFVQKMEGTDLKEIMRVIPLCNVLHSYFILQEMLTRRMLEKEAETGKPSAAVIILDLKGLNISEFLNPLGVQARLARLVISIWSNYFTETLFKLFVINSPALLSVLWYIMKFIADKKTQSRIQILDDPSELLRLLNPQAVPEAYGGKWRDNSGYADPPGSVCRKPLKVLPHHTFDSNELWRKYGYENAPQPITKIHLFLFISQEEKIIKKICEKDDQFLLWQFTVNGDVEFEIIKKKRDGFRAAWPKITSTSLLAPEQGCIRCRRGHYIIRFQNPATTWTPTKIHYSIEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1E7</accession>
    <name>A0A0N4U1E7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM5</name>
        <name evidence="15" type="ORF">DME_LOCUS4784</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1E7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1E7"/>
    <dbReference type="WBParaSite" id="DME_0000042401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000042401-mRNA-1"/>
        <property type="gene ID" value="DME_0000042401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000042401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9938" checksum="2EC3B50C3EFC4454" modified="2015-12-09" version="1">MTSSIASNPSTLLPLELVDKCIGSRIWVIMKGEKEIVGTLMGFDDYVNMVLEDVVEYENTVDGKRVTKLDTILLNGNHITMLVPGGEGPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2H5</accession>
    <name>A0A0N4U2H5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protocadherin Fat 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5240</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2H5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2H5"/>
    <dbReference type="WBParaSite" id="DME_0000088001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000088001-mRNA-1"/>
        <property type="gene ID" value="DME_0000088001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="153"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="262"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="332"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="458"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="588"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="659"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="867"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000088001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1379" mass="154411" checksum="C56A5A95477B4AE7" modified="2016-06-08" version="2">MEIDAESVDSNGIYGSFDLTIMIKNNDPSEIFEQNAYYFEMDKQLKIPIVVGLLKLASDLNTESLEFAFFSLEPSTSDALRLVSLGCVHSCSKFPRQFILIVQAYHRDSSKVANIPVTIHLNETLKAPPKFRKAVVPIGLKERLTSDYHLILEVDDQGSDQLIFSLNDYDSVFQIDANYGVLTIRNSDLLTIDNLGEHFNLTVTVSDDENKSDTAIIMVSLEPIISHKSTAPKFSQSIYAFAASPGETFVGKVRAETIDSDLTYRLSEGGANVFYINSTDGRIFYKGPLEKNARNYTLRILALDKSSPPQVDVTVVQVLIAGLGSSPPKFKSPLANSVMIKKDTGLGALIHRFNATDDDPNAQLIYMIHKIQAYDQLGNEIIDSSEYFEYFRFPKQSVNDGSLFLSKSFKNSNIMALDLTVTVSDARHPNEPDDHGKLFIHLVLPEQNLSENEMLKFDQIRRTVSVAEDLAVGSYIYTVNVKPLPIHLAKNRRIVYSLSEGHRLFTVHPITGVITTISSLRGTGNSTVTITANQQNTQASSSVSIMVAAIPLISRSAPKFAIDSLVYNIYENIPIGSAIGEQLVPVTGGNVSYKIMGRDSSHFKLDDEGILRSAMVFDRESNPHLGAFIYVTSNLSGQHSVIPITVNLLDQNDVEPLFPQKSYAATVMENIPINSFIIKAEAEDADNSSLLEYSLMMNSESSALSSLLTVDRNGVIRNAEPLLGLDGKYQFAIIARDGYHSGTSATIFMTILPTSKCQPSFSEPTENIFYLKENEEPPKELAHFIGSVSSEDCHLIYAIWDGFQYVNSTEFFEIDPETGILTSKVAFDYEEKNKYSLIVAAQSNDLFSQILIEIRIIDIDDNSIEMLNRELYLNIREDEALGRIITEIQAVDEDTSDKIYYHMTGGDGKFTIGLESGVLTLAKPLDREEKESYVLNVIASNFENYSTQDSKSDFATIYINYQNYMNCEALSRISQIFSSQTTLFYVFLCILINDNGPIFEKDIYMSAISSHLLAGAKIMTVSASDPDVTTNSSPDLSKENVKSRIVYRIDNTYYRYMGKVRQADGFIIINENSGEIILGKSPKEFTGGLFEGRIATSDISDIQSHISTSKIKAIFLIRKNEIWIYDESNIVQVYINENPKNLDVAQLEELMRQLSELCACRILPIDAKYVKTDGYVQRDALWLQLIFINTTTDVILLAENAISLIDKNILTPTSSIPKLSSLENSAKIIKESTLPTSRFRETALLLLVFASILITVLIIFGFILSYHRSKFLREKKAYEEEKIALGTLNKINRFKQPSSYIKPRSHNLRWFYRICMKLESSLKELFFFTEGEALGKAWTRAASTCREKYPNSNSSSIYGVQEVHMIVDASDMPSKKRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2J8</accession>
    <name>A0A0N4U2J8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5267</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2J8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2J8"/>
    <dbReference type="WBParaSite" id="DME_0000090701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000090701-mRNA-1"/>
        <property type="gene ID" value="DME_0000090701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871302at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000090701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42337" checksum="E74C212B6E16D845" modified="2015-12-09" version="1">MVYPEMDQVGIIHYIPHHEDIRGQATENNIEHYRFHRVPFGVISSPFLLSAMVNTTWKIMDQRIWKDFADKICGWPISERNTTRRNCPITIYKNSCLLSCFLSCLCCSSVYIIQDKKASLVFVKSRIAPIKNVIILGLELLAELIGICAVQKEEEIIKWNLYNEGIWKSKGGLENSELEEQELHPIYLPRENRITEDFIQQQYEKMFRARTAHTTSSLKGFGCQKEEQKSMHLELDSFSAESFLSVFKRFVSRRGCPAIILMTMRVNFSRKLLKEKEFMPLIVEIESILNARPLTYANFDDSTILRPIEFIIPDVCLKIPTNNTDDRDTFHKLNTQEKLIKYWVSTTKTLDIFWENKEGGVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2U3</accession>
    <name>A0A0N4U2U3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5379</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2U3"/>
    <dbReference type="STRING" id="318479.A0A0N4U2U3"/>
    <dbReference type="WBParaSite" id="DME_0000101901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000101901-mRNA-1"/>
        <property type="gene ID" value="DME_0000101901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF25">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000101901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="22164" checksum="1D131C4A945F9C2C" modified="2015-12-09" version="1">MSLNGNFKCLIQFRFFIFHFILFRHPSIVISHIVFRLAAILFYLSAYLFTDSFIIQFLVILFLLSFDFWTVKNITGRLLVGLRWWNFVDNDGKNHWRFESAKDTNRFDAFERQIFWGVLVIAPVMWSIFATIAFLTFKWEWMIVALMGMAMTTANLYGYLRCKWNNAQELSNYISKWAFFSVIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2U8</accession>
    <name>A0A0N4U2U8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5385</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2U8"/>
    <dbReference type="WBParaSite" id="DME_0000102501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000102501-mRNA-1"/>
        <property type="gene ID" value="DME_0000102501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000102501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42118" checksum="6831423914AE0690" modified="2015-12-09" version="1">MKDKCKNGTFKPTNEQCRIQNAGESGAVTVEPIHRPQRYRLPSRRVGSPIAESVAMKENPLSKFRFDMDEANTERKGSDKEEKDNHSRQLFQAVEKIEQKNISFRRPISTRLRFPDKRLDSSGIISQHATFETTSKESLFTTSRLRKKHATCAIFSCCGDSTTFNIARDCDASVKEGTDIIASNSASKKEGTNFERDSLQTSKNDTKKKKFEKSITKKILHENINLKKTIKELKNKIKEIQKYQNNVNQLICERDKLLNEKVHNDILYEMQSELIHKQTITIENLRLENRKLNEKQQRLLQRNFDQWAMHLDFGSSNGKQLEIMESIIVEDDANISSALHDQNQEKACDETKIKWSNDSWMLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U367</accession>
    <name>A0A0N4U367_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">39S ribosomal protein L20, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5520</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U367"/>
    <dbReference type="STRING" id="318479.A0A0N4U367"/>
    <dbReference type="WBParaSite" id="DME_0000116001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000116001-mRNA-1"/>
        <property type="gene ID" value="DME_0000116001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251781at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000116001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22721" checksum="D3928A14F09AF9DE" modified="2015-12-09" version="1">MRVSIINCLRRIIDSPYHCFKVIPKPDNWQKREKLRRFVAWQYATRRSTVRMGYNALNKIFHSWNIQRMDKLKLEKHYARERLDSALAEHHFDYPNFRNMLNKAHILLDNIVLSQLAIYEPRSFKSLVMLTKQMAHEDGKKVINDIEQKYVETDPSLFDTPFPYTKQFLRRRGTNYKDPPKKLKESEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3P3</accession>
    <name>A0A0N4U3P3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5713</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3P3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3P3"/>
    <dbReference type="WBParaSite" id="DME_0000135301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000135301-mRNA-1"/>
        <property type="gene ID" value="DME_0000135301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855770at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="72"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000135301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31556" checksum="5B7CAD576A16C297" modified="2015-12-09" version="1">MLRSCSPSMTALMHIAGLPLSKPPAWPTIGPLRFSLSNNFVNYCFESTSRYFSRRLATPSHKKEKRLDEKEAVEVICRLCPYQGNDPCAILVDETHIKLVPPASASRSGLPTTESIYKLSYVFDETDGQRAVFERSAVDLVENLVRGKNSLLFAYGITGSGKTYTMTGDTTEECTGILPRTLDVIFNSLSNQVDKCIFRPDGKNGFEVISEFEAALARQRLKISNDDDTYELANRYMEPRRVSGVNFEMLYAIFVSYIEVYNDVCYDLLDQTIVNRDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U460</accession>
    <name>A0A0N4U460_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5914</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U460"/>
    <dbReference type="WBParaSite" id="DME_0000155401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000155401-mRNA-1"/>
        <property type="gene ID" value="DME_0000155401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="521"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000155401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="641" mass="73454" checksum="8C1ABF5DC8078B02" modified="2015-12-09" version="1">MLLFISARSLENEGNYYYGIPLGVLRYSKDRTHAEVFAADDQTIIFHKFTHQPQQLGCTSIMIGPQRSKDSDWEQSNGVLLQLSRSEFAKRLTRIKRSPQLAFSLQSMFNWPTEFDHLKLPEKIKSRPIKSFINHKNPFAGIDIAISNTLNVSRPHKDIIINDTAFSDSTKIFQELTTSTISGVVSSRRPPIITTLFNKESSTGTDFTLTICYINYILRIILHKYQKANIKDQNQEINKPENALTNEQESFFSKITNFPARSIPAEVTESQLEVPKEIAVTIQNEFTDRFIPKLFHEIKKSPDKGPGMIVINPDTGEEIDLEEPSLVNVNMDREVSYLLFYRKKYFQDWETGTSQGQLKKQINGPNLLHQEVLKMDIEEVSPEENIYGKSTPLYWVVEDPRMKRRRQKKIQRIKNEKEARNVDVILPPAEDISMLLAISTKSQPELSYASLPPLTTVGLRESSHKKYQLPLLIGETVAFLLSDDAKLADYQWIGIYDICKDKAIPLISLKNVDPPRRERIAPLVGWSHNISSHGVEILNCNTILIPGFVYDGGNSPQGTYFYIGIGHFPDFIEKQMRTKVVGTPLHEPLRNYYDEDIIIRLPNAYRTFDIDFISIFNEIEKKSYGYVTIPSLLVPPCKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U469</accession>
    <name>A0A0N4U469_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Olfactomedin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5925</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U469"/>
    <dbReference type="WBParaSite" id="DME_0000156501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000156501-mRNA-1"/>
        <property type="gene ID" value="DME_0000156501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5822246at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041080012" evidence="1">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000156501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="34330" checksum="8C589C914513D238" modified="2015-12-09" version="1">MTINYLANLTILLIFLLATILRAQPILIKDIPESSASWEQDEQLPFEDYEEIVQPMKIPKLRREEKIAKILKTGQDRARELRRRVRYLNKEPVWRRVVPLPTKPLRGPLLALPITECPKRFDAVTRAHNGRTYLFSRDRVYQVWRKDNLHQRSSYHINDLFVDGPRTVTVAYTNLRSGVTILIEHSTVYRFRWNRKAKRFMIARKSPQPLHESAQLQPRVGFQWIDGNQILMESDKFITYDAYWNFPTFSGIASNYFPNLPRDIIGMAYQDGSSFLIYTASNKIMKSGDYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4A2</accession>
    <name>A0A0N4U4A2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DME_LOCUS5959</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4A2"/>
    <dbReference type="STRING" id="318479.A0A0N4U4A2"/>
    <dbReference type="WBParaSite" id="DME_0000159901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000159901-mRNA-1"/>
        <property type="gene ID" value="DME_0000159901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF31">
        <property type="entry name" value="INNEXIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000159901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="46853" checksum="2DED4DB2F52D87DC" modified="2015-12-09" version="1">MMIEAIIAMVRYLSPRNDDDAVDRLHYLYTPNILLAFAVLISFKQFGGRPIECMFPSKFPGSWEQYAENYCWSQDTYYVQDDVHVANIPEEERYSPERKLSYYKWVPFFLLLQAAFFRFPSILWNYLSLNSGIRIHEIIEKAVDRGNLEDAIRKQNIDSLARHMQNALKFHRQKIEVHKTFKFLNIRYSAFFISLMYLFTKTLYMMNAVAQFYFFFWFLQTDRYAWYGYNVVKDIIQGSQWSFSGYFPRVSLCDFLVRQVGNIQRYSVQCVLVINLFTEKIFIFLWFWYMILIITTLLSLSYWICVLTFPCFSRWFISQSLELSEQKFDPDTKKREVDRFVSQYLRHDGIFVLRLVSIHAGIIFCTELVLALWAAFYEIEEQVNWIHIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4C9</accession>
    <name>A0A0N4U4C9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5991</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4C9"/>
    <dbReference type="STRING" id="318479.A0A0N4U4C9"/>
    <dbReference type="WBParaSite" id="DME_0000163101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000163101-mRNA-1"/>
        <property type="gene ID" value="DME_0000163101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000163101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10432" checksum="20E3F647DD598171" modified="2015-12-09" version="1">MYRYLLSIEFACRHVIIPRTLVKFVPKDRLMTENEWRDLGIQQSRGWENYMVHARELHNDFRRRLTFFTKSDSGSSSRFLCLSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4F1</accession>
    <name>A0A0N4U4F1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6016</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4F1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4F1"/>
    <dbReference type="WBParaSite" id="DME_0000165601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000165601-mRNA-1"/>
        <property type="gene ID" value="DME_0000165601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876856at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002601">
        <property type="entry name" value="C6_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31507">
        <property type="entry name" value="PROTEIN CBG15923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31507:SF3">
        <property type="entry name" value="TIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01681">
        <property type="entry name" value="C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01048">
        <property type="entry name" value="C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C6" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000165601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21065" checksum="60FC175991F07480" modified="2015-12-09" version="1">MENTNRNSREATNGVQCEICRQIPVLFVNNQTLCNGRFTIRYSTAESCQSLTATCSADFSSSNVVIMNSNKQLLAAGVGTAVIGFVCNNNAMWQSSDGAEQTGLACAAQIPDPCAQTMWNEWSNWSRCSKFCGSCGRMSRSRTCRNESIKCSCVGQGTETKVCNKQPCLHPSQMCCSGYVLGAEAGVFACVEVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U548</accession>
    <name>A0A0N4U548_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6312</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U548"/>
    <dbReference type="STRING" id="318479.A0A0N4U548"/>
    <dbReference type="WBParaSite" id="DME_0000195201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000195201-mRNA-1"/>
        <property type="gene ID" value="DME_0000195201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF2">
        <property type="entry name" value="OS02G0536400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000195201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18496" checksum="478FA36C2D500F68" modified="2015-12-09" version="1">MKSRGYGFVAFTVKENAEKAIDEMNGKIIGRRQIRTNWASRKVNSSDDSSLKELTFEQIFNATYPDNTSVYVGHLSLTTTEEDLREAFSSMGSISEIRLFKQQGYAFIRYSIKDSAVRAIMCMNGKEIKGSSIRCSWGKIISDTNVRFFNLFMAKVFHPQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6E1</accession>
    <name>A0A0N4U6E1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6843</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6E1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6E1"/>
    <dbReference type="WBParaSite" id="DME_0000248301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000248301-mRNA-1"/>
        <property type="gene ID" value="DME_0000248301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="159"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000248301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49351" checksum="527AD139AB3A0392" modified="2015-12-09" version="1">MAEDDLNKINKMSDSVQPKLTPLEAESYYHGFLPRNDANSLITLDGDFLLRTTEIASGDKRTLCLSIRWNRYPHHVIIREKDGKYGIDPTKMFSSLSALVNYYRKETIPIENIKALLKNPILTQHHAFMLCPLTLGTLGKFVNKKSEQIQIWELKHSQIKLIKKLGEGAFGEVHYGQLSLTPTFTVEAAVKLLKCGTLNKEKIDEMMTEARMMRNMRHPNIVLFYGVANKHEPLMIIMEFMKSGALNNYLLSKGNSVTIQAKMSMACDAALGLQYVHKLGIMHRYLDIASRNCLYDDKVLKLSDFGLSRKGDSCKLNPNEKAPVKWLAPEVNKGYRLQLPVQAPAKIKEICERIWAKNIYERPTIDVIATELLKETGRLISEEPKSTSYDKAFSGDPKFTLHDRSTSNSSTTPTSTLTSSSLPSQESQKKVDSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6G4</accession>
    <name>A0A0N4U6G4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6869</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6G4"/>
    <dbReference type="STRING" id="318479.A0A0N4U6G4"/>
    <dbReference type="WBParaSite" id="DME_0000250901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000250901-mRNA-1"/>
        <property type="gene ID" value="DME_0000250901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000250901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33102" checksum="DC73229895BE54DA" modified="2015-12-09" version="1">MSLLRFVPEYKAPTKEAISKFQNVIEGFNKLIVMTGAGISTESGIPDYRSEKVGQYARSNHRPIEHRDFMQHVEYRKRYWSRNFVAWPRFCESKPNLIHETIASWEKTDKFVWLITQNVDGLHTKAGSKMLSELHGCNRQVKCMNCSELYPREIVQEWIKHDNQNWLVTEVGELAPDGDIEISDEASQSFKPPHCPKCGPGSILKTDVVFFGDCVSSDVVELCYDKVFESDGMLILGSSLTVMSGYRFVLQAHSLQIPIIIVNIGPTRADDIATIKLSAKCSDIIKNIQILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6R8</accession>
    <name>A0A0N4U6R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurexin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6995</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6R8"/>
    <dbReference type="STRING" id="318479.A0A0N4U6R8"/>
    <dbReference type="WBParaSite" id="DME_0000263501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000263501-mRNA-1"/>
        <property type="gene ID" value="DME_0000263501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162704" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1099"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="129"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="300"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="717"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="881"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000263501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130531" checksum="5BCD9B7FA1934072" modified="2016-06-08" version="2">MDIIAFTVSLMLSALSVIQVNADDCKELSFSSLTVEFDSIYVLRRIAVISPLTVYHVFIEISDDQRIRSQLRSSNGSPLVIYSSLTPSAAEWLNLDELARRIYVTPVYELNNNLNNPLIMINACKYDTPVSYFDDKLFTVDTYKAGIASMYENDLDIIFRTFENGIFLFSMADQGDLLIAQIVGGKIHVIFDFGSLSPLIISGGIALNDGEWHRMKWVHQFDSVLLFIDGVMMNSTIPTGLYRKLDFDIKIHIAGRPPDDISTGIETTYHGCLAKVTLNNVDLLAKLPEDYKRDCQIPRPQLMTISKGGYVSIPFSFLPFSIEFRLLQEKSTVLLLSDNQNDTLLYIALDDFGHLTLFVDQANIKQVAYPAIRVCDGSWHTMSLMIWGARLHIDVDSLTVLWLEGAMVKTIAKKLATFHLSAVGCYRSATVFFRSVDIVGNVSLDLCEYREKCVPNPCENGAICKQTLLNDFQCKCEKGYYGRLCHASSNVHSCEEYLAKNTKIVSKNVTIDMDGGHQLEPASVLCSRINENDHAANIVKTTLFHDMSMSGIVITGSVDPGTIRKSLKYGLNGDQLDRFIEGFDDCEQYMRYECRGGANLMTYGLEKRPSSWYGTRKGQHGLQWAEAPPYSRLCSCALNSSCIHDRMCNCDSGEDAVDDGYNRYPQLLPVMNLYLGGTTQKSSINVTIGSLTCSHRSKRILKMFYFSSRFPTPVFDALTFLDKDFRLTGSQPFTSTIFDVSMQLKFSYSKMTVFTWESNNGQRWFQLYVAGGKFIGQVVNGGKVFEVETKNSWNDNVWHSVYWEVNEYEMILIVDDEKISRELRILPPHVYNWIIGSRTLRGYSGYAGMIRNVYLCGKELILASIVRNIHGNALSGVEIGEKGACKPDFCLNGGLCIDYYDSFKCDCNNTPFIGSKYVGMLVPLGSQLSIPWQHPGQIASCFRIAIQTFSSNFSIIHSHALFADSEFNLTVNADGYLELSVFDGFVFERQATCPLHKLNENKIADIKFCANKTGFHLLNVNDSIIADFTGCITRLQIGSGFPLKEPSSSRLSYKGDIRFGSCPFEQQLLEPQPEDDDNLESDEESEIRIHIVTHGRTSLMILTPIIGIVGGCAIILLILTIICWIRSRPDGVYKTNENVAAYSSSNRSEEPLVNNFNKEYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6W5</accession>
    <name>A0A0N4U6W5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General vesicular transport factor p115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS7056</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VDP/USO1/EDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6W5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6W5"/>
    <dbReference type="WBParaSite" id="DME_0000269601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000269601-mRNA-1"/>
        <property type="gene ID" value="DME_0000269601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045056">
        <property type="term" value="P:transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="11">
        <location>
            <begin position="359"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="12">
        <location>
            <begin position="764"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN57083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000269601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="879" mass="99750" checksum="E2C288B2BE7A8252" modified="2015-12-09" version="1">MAYFRNLFGGQNDKSRDLANNAAEIIENLVERVETSTALDDRRDALKALRSLAKKMRLPVATIGMNAYMDILEKESLSPDIVAITLEILVAVVSDDEDSEEGFIEDKFQGNDEISERLAEIIVRKKKFIPSVIALIESYDFNVRRAAIQLLTALLRHRASEVQAMVIEQPVGVSRLLQLLYDTREIIRNNAVLMLGELSRSNSQIQQLLAYENTFQLLLDIIDLEPVESIVIEDCLFVILNLLRKNSSNQELFREASLVQRLSVLLHLFFYGREDETDGNQESEWPRQKIANLIFLLQVIRSLVSPSENAQSTVSIAQKTINRSGILSELCDVLLSELGLSVDILTETVTAVAEIIRGNYANQEYFASRSLMTTAGTRPSLIVLLMSMTTEKQPFKLRCAVFYCFLSYLHENEFGKTKTIDTLLPANSTNESEVTTGQCICSAILSSEGIQVWMGCVCLMHCILDVDHLKQQLLRVQLSTTVTDVPSSLLQHVGSLLVSLGNRKPQVRIGLLMLLSVWLCNSPLVISHFLQVDENIQYLTTYIDDCGVEGTESENQVVKGLMAVVLTIFERRIGKIKLIELFEEISRSEHYVRAAQRPQPLAKSSQELILDYQFSKFFKVLEGQLTKLLRPEFESTSSEMNGATGSVVASFKELIKRQDETIADLNQQLKKLNDELSSNVQFFVAFVKVNGKSYHNEVISGKELAEKCTLDDHKKEIDRFATEHYQNIVSQWQAYTQRYQQWAEQWQEYQISQLPNPQDTVVNQLNMQVKELEEQLNYGWQMYEAQTSSLVQSVNECYELKAQIKSLQDQLATAVQQLNLFNSGHKSVEVNNSEELISLKKEQEDLLVLLADQDLKISQYRQRLVDLGQAVTDDEECVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7U3</accession>
    <name>A0A0N4U7U3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7232</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7U3"/>
    <dbReference type="STRING" id="318479.A0A0N4U7U3"/>
    <dbReference type="WBParaSite" id="DME_0000307301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000307301-mRNA-1"/>
        <property type="gene ID" value="DME_0000307301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF40">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="598"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="11">
        <location>
            <begin position="915"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000307301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1311" mass="146314" checksum="CE216E7C60D63BC5" modified="2015-12-09" version="1">MNFLTKYGLSLSGYRTGKIGNAMEFSQLVAFLVLAVQVTSLWSLKANGTFVNSAQNRQLIALPPIINELSNHNAPLGSQANPIVISQDFDKETLEFINNEESLSNKPSNVAELETMVFGKITRNNHASSLLQTASRPSQLPVLKISTIHPLLTTVDKVPLFYGGRAALPTLFGDLNEMEERRTVYSNERFDEPIMTQHESEDFGKVFIKDTTTDEYERSTENNFYELMDEGLIAVVDGKRSKVMQEVEFHRDNSDKNFYKDEIERLNETREIEEEIKKGKYTAVPPLAPSSFEAKMGHFAVSTSSIFQPAPLLDNVLLRMSTGTPDYEVTKISTKSSLQSETTTLPLGKKHGISIFPITRSPTEQLNDQTLENYGTDEGLFTAISDEKNKSKQSEGSKAKMQKIDTIGEEDIETLSDILSEELKKAISTVLPPRISLQKMEISHFKNSTESKKIPEITRALSDISLATPIRTREQQTVYVFTTKSTSATPLSKDAESTAEMPKTMGSSKEIRSTTPAKALWLIEFLPTTTEKTISTSDNKFNGKSNGISMESITSEMTLKSQVMKALTTVSSTKLSEFTPAKTDCKIENDKTDLTKANVMFLIDSSVKMGYEKFQGAVKLISDTVKEFRNIGPNGIQVALVQFAEKCLLEFSFDKHHCKETLLEDINDTQFLNGTNNLEDVIKKVMADNLINYKGIRSDVKKLLVIIADGSSKDKIQQPFELVKKDGINILVISTIEAHPDLVMRFTSSRGKADFSPKSLATRLADRIREIAQSDQLNGETSYNRRTEDVMETSIEESERIFEEDAEKIFDELLAPSLDNYTSTTKSSIPTTENAFIYSLAQQSTMPSGVFLESVSSTLIESTHATTSNEEQLTMYNEQLTTMTETGFISKEPVSLSLPSETKIGVLSAGDIKLNCTNRGFGLIMQFPEAYRGFISIQGSPQTENCSAEIQNVKKRVNAENARRTVHFFADFEQCSINKIRSSNPSGLNISALIRVQHNPVLVTSGDKSFLIECFFPDTKRDLNVDLHISRARGVGETVALEAIPPTCSYSLRRDAPNGPLVSSAIVGEILYHRWECKGGIAVEDVYGMLINNCIAESSDHLRNHSIVDSEGCSIDKDILSDLTYSDDNLIATARSNAFTLINTNRLAFKCKPPVCSNETQLLHQYSRRYSESLTAALTTGVTTNIRISPSSPSSSLTESEPLDEQSVNWKERLKKLVVIPVFWILILFTTFASVLAIVLVRHFRQQNYEINDECSVNSGFSDEYNYRPSNRIVFDGRMDHIQTLNSMVPDRRIFLKSRAQQVKTTNQSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U804</accession>
    <name>A0A0N4U804_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7307</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U804"/>
    <dbReference type="STRING" id="318479.A0A0N4U804"/>
    <dbReference type="WBParaSite" id="DME_0000314801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000314801-mRNA-1"/>
        <property type="gene ID" value="DME_0000314801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000314801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26464" checksum="8B968DE58FE0C853" modified="2015-12-09" version="1">MATNGSSCVTHVIFDLDGLLLDTEPIYFKVNEIILAQYGKKYTLELKVKTMGMPKNRAIAEAIEYVGLTGQISIDEYSTKYEEILRDLLPDNNLLPGAMRIVEYFHKNKIPLAICTGSCQYEYDMKMQKHKELDALIPFAVLTGDDPEVKHGKPDPDGFLVTMNRFKEKPSCAANVLVFEDSPNGVIAACRAGMQVVMVSDFSYYEPPEECKDRIVTMNSLEDFKPEQFGLPPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U895</accession>
    <name>A0A0N4U895_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7412</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U895"/>
    <dbReference type="STRING" id="318479.A0A0N4U895"/>
    <dbReference type="WBParaSite" id="DME_0000325301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000325301-mRNA-1"/>
        <property type="gene ID" value="DME_0000325301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="518"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000325301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="694" mass="78071" checksum="3BC923EC28B34255" modified="2015-12-09" version="1">MEVSRPLRHDISGVEDDDGITMELRRRLKRVASIPCDIDPMAIDTSIDFTKIGGLDRHIQSLQEVILFPLLYPEVFSQFDITPPKGVLFYGPPGTGKTLVARALANACSKGARKVSFFMRKGADCLSKWVGESEKQLRLLFEQAYKMRPSIIFFDEIDGLAPTRNSKQDQVHSSIVSTLLALMDGLDNRGSVIVIGATNRLDAIDPALRRPGRFDREMHFSLPDTNARLAILKIHTAAWNANRPSLENLQWLAAKTSGYCGADIKSLCTEAVLVSLRSKFPQMYTSSEKLMIDPALLVIDKSHFITAMQRIVPAGLRDFSVPSRQLDDRLAILLSSTIKSLIEDKVPTGYRSSYQHDMVEISVTEKVLKTLAASPVVPSVRLLIHGNSSDCGQTSYVLPVVVNCLDHLPVFSLSIASLFSSGSPEESFSQAIQSAIRSASTGTPCILLIPSVDMWHQTVPRSVWNLLITALDSFTGFTSILLLASAECHYSKLSWKFYIYMSFFVKNLDFFINLAQFSRDRRFSAFAQPVDPAEVPDYYDIIKNPMDLSTMFSKVQSYKTPEEFVNDFRLIYANAMEYNPPDAEGRLIQQNAKLLLDLGQRAAFELDTNFLRGIEAVEKCSGWPLVELERVAAALAQIIDSYRDIYDRTELPSQLLLTFLANRCCWHISILRRNWHFLFFILFLLIFNCGFIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8A1</accession>
    <name>A0A0N4U8A1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7418</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8A1"/>
    <dbReference type="STRING" id="318479.A0A0N4U8A1"/>
    <dbReference type="WBParaSite" id="DME_0000325901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000325901-mRNA-1"/>
        <property type="gene ID" value="DME_0000325901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877731at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000325901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="24826" checksum="BC5B8CAD20DE8E9A" modified="2015-12-09" version="1">MEVQSSLIAANHEPHHKKSSQYTMLDRFKRLTNERFIELPEWCNCDLLPTCPPSPRGPPGEPGQDGEPGVPGHPGIDAVVFVPAQCSVGCFKCPHGPHGPPGLDGPPGSEGPTGSPGMPGRPGRPGITGPQGPTGDIGEPGERGPQGEPGLSTFYTTANTKLRRGRKGLPGIPGPAGEPGIPGEPGEPGIPGPAGPPGPPGPMGVNAIPGDNGIRGNPGLPGADAFYCPCPPRSFAFIRRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8M0</accession>
    <name>A0A0N4U8M0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6 9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS267</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8M0"/>
    <dbReference type="STRING" id="318479.A0A0N4U8M0"/>
    <dbReference type="WBParaSite" id="DME_0000340101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000340101-mRNA-1"/>
        <property type="gene ID" value="DME_0000340101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2359216at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050290">
        <property type="term" value="F:sphingomyelin phosphodiesterase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000340101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="74387" checksum="5FE3DB84BC67EE99" modified="2015-12-09" version="1">MDFNGSMTRLSMVCGELLARMNSQVCIIDAFFVSTVVEQLFCDPQIDLLAVFPTSSTEYDEYNQVLGLVGVKSSVFKIILELDNEIFDYFISSFCSHVERSRCLIPVEEIKKSVYMALLASYILVLMPVDDESTLMARELHAVDTNNSLLSPLNIFREEALRRYALSPSNHSLRVLRSVSRSLSPHFLSFICVLIRSYSSLSAWPTIHRLNILSFVLKEVHSFIMAETENLNLTQMRSQLQCNAPFADSLFNFFQVLLEKWPANDSFEKLFDVWITWIRPWCYSCGRDGQNVNDIHHFLPFIMANQRFYTDLTGIFWRRDFVLKQLTDVVCITKYICILTSAELLQIYEMLDYNIEEALLTFVKTLMICKRNLEQTIIEKEKSLSSLNWLQRYYIAEEEEAFIVEKKRTLAEINSLLLKFKNSYGESSGITIENMAEFLSMNKNSNEDENITYCDNYSANESIEKCSKLLKKHQYFHQIFNFFTFINFILFTSKFLVFQVLQRDNRFSSSVVSQSIPSILEPLRSDEVWWLARRLFIISCFLNETKLIRLLSRSYHDSNSLFGIISRFCLCCEASPNAIRLLNSTIRTNEPFINFRYFARYKVIIPVCLFFVLIWLLPFSYSFIIFNLTLIYMHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8W4</accession>
    <name>A0A0N4U8W4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7507</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8W4"/>
    <dbReference type="WBParaSite" id="DME_0000350201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000350201-mRNA-1"/>
        <property type="gene ID" value="DME_0000350201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720878" evidence="8">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000350201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37131" checksum="99EB355B98517756" modified="2015-12-09" version="1">MDIRYIIVLIVFIFSYCLTMDNEIVGTPVVDCEDTVVSLTFKTRKPFTGRVFVRGLADDVRCSRNFAKNIDRKKFSLIIQNGDCTMQRQRVAGKLEGIMFSLTIVISFHSTFVTRTDRAYRCMCFFRNIKHITSSIDMSPIVTTELLDTAKMPTCTYTIHSNSADGPPVVFGQVGEKIYHVWKCDNDEQGFLVHSCYVNDGRTARFDLIDLNGCALDTIIQPDIQYDASLTRAVVETWGYKFSDTSVLNYQCVIELCKKSAGECEGLTPPFCGRTKRDIKAVKSNLKNSSLSSRSEIDVIAAVDMFDTINEDKIADPHSKDFIKKITEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9I0</accession>
    <name>A0A0N4U9I0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7754</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9I0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9I0"/>
    <dbReference type="WBParaSite" id="DME_0000374901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000374901-mRNA-1"/>
        <property type="gene ID" value="DME_0000374901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="8">
        <location>
            <begin position="365"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000374901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="540" mass="62690" checksum="A69DDE54DED95C9B" modified="2015-12-09" version="1">MKEVGEGFALVVVCIFSLFGEFKKNGFKKQKFTNEDELLNMQKLREDREIIIPKESLALHDTGASEINPKSLRTKFHQEILRKKKEKYIERIRETARAEILNFEEKGFLLPDNDERTYAIRQNEICAAVDLASASKHFDLILERFGPYQIDYTPNGRFLLIGGRRGHVAAFDWLTKKLLNETNVLESIHDIKWLHVETMYAVAQKRWTYIYDNKGTELHCLKNLHDIRQLEFLPRHFLLVAGAKTSFLHYLDVSLGKLIQSFPTRQGPLDVMTQNPNNAIIHTGHGNGTIQLWSPNVREPLIKLLAHPCTVQGISVEGHYMASTGLDRFLRIWDVRNYKSLFSYRLPFGLSQIFNDAHLGASVEPFLFHRCAETVHNLQFCPFEDVLGVGHRNGFTSLLVPGCGNPNFNALLSNPYESKSQRREREVKQLLDKIQPELIALDTTEIFQINTDIMKEESERLQKMLYIKPREIKFQPRNKKKGRSDALKKEQRKQGVRSEMRFAQNEGRKKAEQKFLPTKMQKPVEQKVKSVLDRFKRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9X9</accession>
    <name>A0A0N4U9X9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7927</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9X9"/>
    <dbReference type="STRING" id="318479.A0A0N4U9X9"/>
    <dbReference type="WBParaSite" id="DME_0000392201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000392201-mRNA-1"/>
        <property type="gene ID" value="DME_0000392201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000392201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34069" checksum="E40D956CEFE0898A" modified="2015-12-09" version="1">MSTTRSLYPRYQPNSNNNFIQNRSSLILNENFGILPTSMSLLSSLLDTSCMILNGKPFPFTTQFPILNDANINPTTTTTFKVLSELTTIKDPIKSPFQNITTTTTTTTAFDNFSPLILPTTTTTTATTTERINSIFNHDANGIGFETLQAASTIIDNLKCNNNNNRQIFASERLCSSTQNEEEISINSESRKSFSDFSINRLLKNQNQTKRSSIPSSVDRRQFMFKTQEERNIHGRKQRTIYGTSQTRVLEKAFEEQQYMVGTERELLAERLGLTEAQVRVWFQNRRSKWRKQIRSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Z2</accession>
    <name>A0A0N4U9Z2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7942</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Z2"/>
    <dbReference type="WBParaSite" id="DME_0000393701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000393701-mRNA-1"/>
        <property type="gene ID" value="DME_0000393701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000393701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="31998" checksum="E595D99DD1B8000B" modified="2015-12-09" version="1">MSETKRKGKKPEPVPVSELAPVSGLVSVSELAPVYELASAPEPVSASESVPEMVPVFEMMPVFGMVPASELVPASEPLLLSEPRPASETQSMSEPEPKSAAEMFAPEATSAPELLFATEPVFALECEPAFVPVSAVVSVSVPAAVLGPAPVSDLEMHLSLHILEIIPRIDTFAVEESDTPAEEWDAVDEEWDAVDEEWDAVVEESNAAASERWDIVAAVEESNIDADKSEIAGAVEEADNAVAVEEADTAAPFEIRKLLVERNFATEALQIVTVVENSVVEMASLFDFLGPLKSSVAVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA72</accession>
    <name>A0A0N4UA72_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein LTV1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS393</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA72"/>
    <dbReference type="STRING" id="318479.A0A0N4UA72"/>
    <dbReference type="WBParaSite" id="DME_0000402901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000402901-mRNA-1"/>
        <property type="gene ID" value="DME_0000402901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000402901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38614" checksum="4A34556AD7D52CB0" modified="2015-12-09" version="1">SSEHFADYFHEQFYGDDNANGARVDRKLRKKIFELEESNLAPKSWELSGEVTAFNRSENALLEQHIDFDHAAKLPPLVTVDTTRKLESMITQRIRDKIFDDVERKVRESESEVKYRAAVEEQYTKKSLVEVYEEQYQKIHGVNEGKVDEKVIEIGKMMSSLFRKLDALSHYNYIPPEAQSEIHIVNNMPALQREEVGPTASTNEMLIAPEEIKKHIKGTLKNKDERNETDRARERRKKKVALHLKRLKNSVFIDRKKDKKVEKKIKKCKEKRLEERSVKSSKFFEQLQRTTADEVFLNFNLFKLLFRFFFYMKDHFYMNLFNLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAZ6</accession>
    <name>A0A0N4UAZ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8236</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAZ6"/>
    <dbReference type="WBParaSite" id="DME_0000435301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000435301-mRNA-1"/>
        <property type="gene ID" value="DME_0000435301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000435301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="4340" checksum="6B926597FE9A84C4" modified="2015-12-09" version="1">MFQLILLDLMILLLQNKLRNRRLRQSQIFGTFGSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB08</accession>
    <name>A0A0N4UB08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein twisted gastrulation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8250</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the twisted gastrulation protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB08"/>
    <dbReference type="STRING" id="318479.A0A0N4UB08"/>
    <dbReference type="WBParaSite" id="DME_0000436701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000436701-mRNA-1"/>
        <property type="gene ID" value="DME_0000436701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037323at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006761">
        <property type="entry name" value="Tsg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057726">
        <property type="entry name" value="Tsg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057635">
        <property type="entry name" value="Tsg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312">
        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312:SF16">
        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04668">
        <property type="entry name" value="Tsg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23782">
        <property type="entry name" value="Tsg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079477" evidence="7">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Tsg N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tsg C-terminal" evidence="8">
        <location>
            <begin position="139"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000436701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25640" checksum="D1CC8ACA6DD1ADE7" modified="2015-12-09" version="1">MFYSKSAFLLVIFLALNAIQFSAAIFDCSETRCGPRVSKCMLIKACNCSITRQNILSNNCTCCNQCIQCLDKQFTECCSCFGLCNPDREIPRINSYVEKLEQNDEDLIVFDKVASINRLGTTHTFPIMQEYAYDVREGKYMNRIRDSKDEATCTVLYLDQCMSHEECSRQCLVIGATMLRWFHTGCCECIGHTCLPYGSNIPRCKYCTDFDDDSILNQSNRHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB15</accession>
    <name>A0A0N4UB15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8257</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB15"/>
    <dbReference type="STRING" id="318479.A0A0N4UB15"/>
    <dbReference type="WBParaSite" id="DME_0000437401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000437401-mRNA-1"/>
        <property type="gene ID" value="DME_0000437401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF4">
        <property type="entry name" value="BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="59"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000437401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57678" checksum="FF23A5650D62A05B" modified="2015-12-09" version="1">MPICMVIPAEIKRTLFVVVFFAILVHIYRNAFTKLPHYFRGKIYDRRFDEVESAFKQNFYDEYEQGGASLVVYYQNKLVVDLWGGYADRNAARRWMKNTLVVTLSTTKIIAAFCIALLVDRGYINYSDPISKYWPNFRKNGKAKTTIEMVLSHTAGLPYLDQFIPVHQFKNHTVMRMVLEDAKPKWSPGTRMAYHSYTYGWIIDQIIRHADPEHRGLAQFFKEEIADKYAVDYFISLPREEYYRVARFMPITWLQSIKDFFWRTDPRAHPFWLRNYKSMIIDQNDVKTPICENSNSDHQEYSTIKLLSVDRDYFFTNLSSFDNNCDENFVMIPPWLGRRFPSTVNNPNYLQIGEGSMLGVGNARSLAKIFHIVLNNKLSESLQFYLKQSPAKNDDLIMGSNIFRSNGFIYYMTNSSKSSMNKFLDILKFQELWGYGHDSYGCQQVFYDPKNNVIIAYTSNFIKFGTFLKCLPYQIIHLSIYNVLRNLGNSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBF3</accession>
    <name>A0A0N4UBF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8412</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBF3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBF3"/>
    <dbReference type="WBParaSite" id="DME_0000452901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000452901-mRNA-1"/>
        <property type="gene ID" value="DME_0000452901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872583at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000452901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="32535" checksum="0BC1316FB5FB3696" modified="2015-12-09" version="1">MDQTTIKDRQIQANCLRRIAFLGIALSSISTFICIIAVPMFYNYMQHMQSVMQSEVDFCKSRSNNILREVIRTQALTKVGGSVPSKRQAGYGYESTENVPNAYGAYAPYGSSAGAAAPSHAVEGTVRSSGLCCGCGVAPQGPPGAPGADGRDGVDGEPGTPGRDGPDAPEATAPPKAPTCTNECEDAPQGPPGRPGPKGTPGKPGQPGKDADGGKRGPPGSSGQAGPRGPPGPAGPKGPPGVAGKLNETPVPSGPPGRPGPAGPRGPNGPKGANGKAGPLGPPGPAGNPGKRGPPGKAGRAGDTGQQGERGASGACDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBI8</accession>
    <name>A0A0N4UBI8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Costars domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8451</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBI8"/>
    <dbReference type="WBParaSite" id="DME_0000456801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000456801-mRNA-1"/>
        <property type="gene ID" value="DME_0000456801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000456801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32721" checksum="019DE6CC9821DCBF" modified="2015-12-09" version="1">MNLALCCIFSEICVKPTSVLNTAKVKTNGDFKLVFSDVIEDKPTGKSEKHTQKIGQIQISGQSTTSFVDTTIQAKLFNEQLFTNVEANGDFKLTLNDCTEDKGENLKELSERIENLTQKIGRMQSSINDEMVNHETFEKKVVDSVVEHNKRMDKANGFVIIGVPEIFTGLNGMLYDIKFVEKLVEAAGFNKNCIRSVQRFGSHESQSRILQVKLASKNQSNQVLHCPKVKSLLPIGSSIRKDLTLKELKLQKQLWQECHKRNAELNMKKFVVRDLKIVELKHPKVWCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ3</accession>
    <name>A0A0N4UBZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylargininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8638</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ3"/>
    <dbReference type="WBParaSite" id="DME_0000475501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000475501-mRNA-1"/>
        <property type="gene ID" value="DME_0000475501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016839at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016403">
        <property type="term" value="F:dimethylargininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000052">
        <property type="term" value="P:citrulline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737:SF9">
        <property type="entry name" value="DIMETHYLARGININASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="DIMETHYLARGININE DIMETHYLAMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000475501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30648" checksum="B7F4BD027DA5676E" modified="2015-12-09" version="1">MRYTHAILVRIPKTLKLENEKKAKIDLQLALQQLGSLCDTLRESGVEIIELPPEENCPQQSVLLGDCAIFVNGTALITRPKKPGSRLYEIAVALRSSCWQLVETPASERGKEIFLEGSDVLFTGKEIFVGLRKNGTNIEGAMILGRTFADFAVIPITLPGTLPLRHYVSFISKNILVVGSSKEAKQVLQRIERQATFRYKTLTVEQDAAVNCFNVNEYVIYRQDAPDTKFKILQEPLQLWGINCNELIKLGNPISRFFVLFREMKSFKSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC96</accession>
    <name>A0A0N4UC96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS500</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC96"/>
    <dbReference type="STRING" id="318479.A0A0N4UC96"/>
    <dbReference type="WBParaSite" id="DME_0000487901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000487901-mRNA-1"/>
        <property type="gene ID" value="DME_0000487901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052721at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000487901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31984" checksum="298CDFB15F5F7523" modified="2015-12-09" version="1">MKVINSEINSFYQTRFNQLIEVPKLERWFRNDQNPSRQKLVNYMNLLNGSNYRKHNTKITYQQICNWFANQRANHRSSSHLNQTIVHSTTIQPSMVTSTQPILSIDFRPKFDFNTLSENKQSNGVSEAEDVSLEFQEIQRIDGGSDSPTPNDDASVHSTSDGGFDNEIPQKQNPQELVTSSPELSLDLNGSLASTSPKPPSTSNLLNGNGSSAQSQPSRSRLMFDPLTELPIDQYTEALNSCQYRQSYPPISTHNVKIWFKNRRAKCKRMLTGDLKMEKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD24</accession>
    <name>A0A0N4UD24_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9000</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD24"/>
    <dbReference type="WBParaSite" id="DME_0000520101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000520101-mRNA-1"/>
        <property type="gene ID" value="DME_0000520101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867068at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000520101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20534" checksum="892057E9FBB05738" modified="2015-12-09" version="1">MEKFASDCLAAQTLANSVFFISLITIVTIISMIGIIVQIIIMKKYVICMAIHENTRILLVAHQIYLILHCVASIAKIIIDYFYRIVAHTSDLIIYKFNYHDPCMYLSTPLRCFIIRTPVTFTFCILPCSMLLLVAERAIGTYWSAKYERMGRLVAYILILCEVYFIKLIKFFILNSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD48</accession>
    <name>A0A0N4UD48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ca2+-binding actin-bundling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9030</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD48"/>
    <dbReference type="STRING" id="318479.A0A0N4UD48"/>
    <dbReference type="WBParaSite" id="DME_0000523101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000523101-mRNA-1"/>
        <property type="gene ID" value="DME_0000523101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21292">
        <property type="entry name" value="CH_PLS_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21295">
        <property type="entry name" value="CH_PLS_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000115">
        <property type="entry name" value="Plastin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000066">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="112"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="256"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="380"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="502"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000523101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="626" mass="70725" checksum="538F53D7320B7298" modified="2015-12-09" version="1">MLSKEQIVDLAERFSSINENGQGTISINDIQEALKITGIDLPGFQIRELTKRYVGKENVSFNDFENLFEELRIQKDQEVNRWKERIGSVTGAYTVKGLSEQSNEEIVHTIRVEEEVAFSNWVNSNLLADIDLKNLLPVKTENGDLYSKVQDGLIICKLINLAVPDTIDERALNKKVLNTYTKLENLMLALMSAQAIGCNIVNIDADDLSKGKPHLVLGLLWQIIRIGLFNQIDLRHVPGLFRLLQEDETLDDLRKLSPEQILMRWVNYHLEKAGVNRRLMNFTSDVTDSEIYTYLLHQIAPRSAGVTLNPLNVQGNLMRASAMLGEADKLECREFVTPNDVVQGNYKLNLAFVANLFNKHPGLPEPGADEISEIDVVEETREEKTYRNWMNSMGVNPYVNWLYSDLTNGCIIFQLYDVIRPGFVNWKRVVTKFSKLKGMMDQIQNCNYAVELGKQLKFSLVGIQGKDIYDGNQTLTLALVWQLMRAYTLTVLAQCTDSGDALATDKEIIAWVNKKLSFSNKSSQIKSFQDPTISDARVVIDLIDAIKPGIIDYSLVRSGNIEANFANAKYAITSGRKIGAKIYALPEDIVEVKPRMVMTVFACLMACGYMPNMKEISEPIRPLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE71</accession>
    <name>A0A0N4UE71_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4HBT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS705</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE71"/>
    <dbReference type="STRING" id="318479.A0A0N4UE71"/>
    <dbReference type="WBParaSite" id="DME_0000566001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000566001-mRNA-1"/>
        <property type="gene ID" value="DME_0000566001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000566001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13240" checksum="E1D9DDF53E4ABA89" modified="2015-12-09" version="1">MDKLIVELLIDEEHTNCKKTLHGGQTAALTDIITSLHTAVVVRDKAFVSVELSASYILPVKIGELIEIESKIIRIGRKLIFTEIEFRRKFDGAIVVKGKHLLSLVNNANNANYNEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UES1</accession>
    <name>A0A0N4UES1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9417</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UES1"/>
    <dbReference type="SMR" id="A0A0N4UES1"/>
    <dbReference type="STRING" id="318479.A0A0N4UES1"/>
    <dbReference type="WBParaSite" id="DME_0000589301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000589301-mRNA-1"/>
        <property type="gene ID" value="DME_0000589301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="237"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000589301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46486" checksum="081303DAAB90D6D0" modified="2015-12-09" version="1">RRTKCRDRSLSISTERWRDANNSSDGRRYRSESLNGERRQEVPVSSNYHFRYHTNNIKRILLTRKYRDTNIYNDLGIRVTGGKKLWNGDLGAFISAINRNRSKELLGEIKEGDQVLEWNGILLTGKTFEEVERIIGASKGEIEVVIKSTTSERPTRQILKNLNYSRDSVGNDSRSRKNYDETSDYQKEAPPVPVHRCIDGRASPEFDYYPPTAQFIQNFPSRVVANETNANYHELTSLGYLNIALSYDASISTLFITVLSAKGLTYRQYYNTTFYPNPFVKIYLLPGRKVSNKRRTKFVPNSIDPIWNQTIEYIIYPRELYGHYLEFTVWDYDKINENNSLGQVVISLSEPYILNGVARWYPLQAMHQNFVVSGFPGLQFQTVIPSKNTFQSVQQYNPGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFA6</accession>
    <name>A0A0N4UFA6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1045</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFA6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFA6"/>
    <dbReference type="WBParaSite" id="DME_0000610601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000610601-mRNA-1"/>
        <property type="gene ID" value="DME_0000610601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF110">
        <property type="entry name" value="FI17948P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000610601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="706" mass="80734" checksum="33069D717C5049DF" modified="2015-12-09" version="1">MSDLSAVEHKDSFRSYVATFNNQNRPDPINDEPDFLLLKGELISSQCGDVLLDPPFRENLFGKLYCTNFRICFVPLIEKRPDPCCSRNLVFANDFQLPLCSLETIFYSSHPITKRTSSSMKRFRLMTSPASQLDIVSCIKVFSKDFRIWTFDLQRSQFAVNLANNIYHFSHPVSLSNFFHFPVEISYLDHSSSIRFNERKDWIDELRRCHADESSWRICFLHSDRTSQKYLVETYPSCVVVPSEVFDVVIIEYLIPNWSNGRFPIWCWSATNGCALLRSSCCTQDLNSSYLWERILTPICKMHPRSRRPLIISIDISPSQISNAYEKLRELCSIESVAQFLQRDKDWYSLLAETGWCKLIFDCLSVTCSVLHKITENQRSVIIADEDGFNGSVIVSSLVQICGDRYYRTIAGLNSLIEKEWIALGHPFGKNIFNCGFVYNKTLRQTTPTFLVFLDALWQLLRIFPLYFEYSQYMLIALWDLSITGLSSGLTYNSVSERLASNKVAPTFPLSQYYSSKYCAMFTNTAYSLNLLFALDPLSREFLCACASPFDIEFWTDCYLRWVPPANVKDGGKLTQDIALCSVISMAASAASPTYDSVLSRHQFHPAFDSSNINSAFPYIDTLSLAPIFNDMDIITENSSVKSMRLHFENVLPSSSKLLYERRLSGSFFLPHLNNEVEESGIPRFIASSDKHSTKKRNMSAVGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFP2</accession>
    <name>A0A0N4UFP2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1165</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFP2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFP2"/>
    <dbReference type="WBParaSite" id="DME_0000626801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000626801-mRNA-1"/>
        <property type="gene ID" value="DME_0000626801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5911996at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000626801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14638" checksum="B707B33B25758FEA" modified="2015-12-09" version="1">MLEKCRETVKAADKYITDQRAHNFIRENRLCPPPKGHWTMTFSKLFTTEDLPKSFFGPLQSNEYWLTFSFTDGKDKKIACARIWIDVCKYHLQDKQQKCLRDPNAFKNFINEISSQAEQLRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFX8</accession>
    <name>A0A0N4UFX8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9481</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFX8"/>
    <dbReference type="STRING" id="318479.A0A0N4UFX8"/>
    <dbReference type="WBParaSite" id="DME_0000637001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000637001-mRNA-1"/>
        <property type="gene ID" value="DME_0000637001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000637001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42261" checksum="2D776900E5D842D5" modified="2015-12-09" version="1">MGGNDEPRFRVLHVSNISTTATREQIYQLFAFIGRIDEFKVSFLSSFTQKFAYVKFEDHKSVEVAQHLTNTVFIDHALVCVPSISDVIPDEETALKTGGPAWPGQRQLPPNVTNQVQDMGDGTQMLLTVDPTLAALGLPPYPALSADTDPAKVEEIRRTVYVGNLPKDIAGEEIMQFFNDNIGEVMYLRMTSGTENLPCAYAYIEFTNQPTISIALQNNGIEFRGRCLRIQHSRVAIIKPERKTADMALQEVEEAIRVNQHPEKSSIDRAYSPLRRSPSPRRRRSRSLERRRRSKSRSRSRRRHSRSHDRRSRSRDRRSRSRERRSRSRSRDRRSRRSRSKERREKEKVKFCKIFCHDRKYMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGL8</accession>
    <name>A0A0N4UGL8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1288</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGL8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGL8"/>
    <dbReference type="WBParaSite" id="DME_0000664401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000664401-mRNA-1"/>
        <property type="gene ID" value="DME_0000664401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
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        <property type="entry name" value="Chaperone_stress_response"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
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        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZUO1-like_ZHD"/>
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    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="205"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000664401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="57772" checksum="A5C166819EF23F66" modified="2015-12-09" version="1">MLSNPTGSNNWRPRFAAVRPQISRGMPCYYEILGLERDVDEGTIRKSYRRLALLWHPDKNPGRVEECTKQFALIQEAYEVLSDPHERAWYDRHREQILRRDLDEHYEDNSLNLFPYFSSNCYSGFDDADQSFYTIYRRVFETIANEDYAYIDDPSVKYPTFGYSNSSYIEIVGPFYGFWQGFCTSRTFSWLNKYDTSAAPNRTIAKAMEKENRKYRDEGKKKRNEEIRELISFVRKRDKRVQQYKKELEERRIEQHKKAEENRKQMIQNRLNQLNDYKETDEIRQNYLDNLREIEEALDAEYGEIVNNIEDEGSLYCILCEKAFKSQKAMANHLKSKKHKETLLKVKEHLKAEDVLFLEAEMNIEEDLRRNISSSLEKKKNKKKSRRKESNLEFNDENNSSEFCEERKKIEEDYKKKKKKSNKKNVGIHILKEACTGPKIGICDKCSAVFESRSKLFMHLEESGHASLKISNMPQKRKQKAVKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGS7</accession>
    <name>A0A0N4UGS7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GCV_T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9738</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGS7"/>
    <dbReference type="STRING" id="318479.A0A0N4UGS7"/>
    <dbReference type="WBParaSite" id="DME_0000671201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000671201-mRNA-1"/>
        <property type="gene ID" value="DME_0000671201"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720416" evidence="4">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="187"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000671201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29321" checksum="67B0AF4F9D20354C" modified="2016-06-08" version="2">MLRKGMLIHLLNRSVLSVRGVDAAAFLQATTTNDINLLKANEALYSLLLNSRGRIVHDMIIYKQDANGCFFIECDASHCGKLQNIFNMYKMHKSVIIEKSILKVFYSDSIHTGSVKDPRVASFGNRVLSENVPDGTLSDMMNYQEKRFDYGIVEGVAETSGEIPFTNKGCYIGQELTNRSMTVLEIRKRVFPFTCSDMVSGTVLNERSETVGRIIACNGRKGLALVNLKKGSTNSFQTSKGSIALCVPHWWPYNLSRKCMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHT3</accession>
    <name>A0A0N4UHT3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Condensin complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9859</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHT3"/>
    <dbReference type="WBParaSite" id="DME_0000712901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000712901-mRNA-1"/>
        <property type="gene ID" value="DME_0000712901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000712901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31377" checksum="2A49129ECD959811" modified="2015-12-09" version="1">MLQMAAFTIINVSSTAVTARVRRLGDFFAVVIKFLMKRNYTQISCDNEEEKNDFPGIDFKSFESISAAISDAEKIVTGYEEMGDGELCCLTMLRFYNGFEWMMLLMGIAKEYNEHIPDRKGINNATIPPKIFDMLLKAFINCGAMKLNDDNWWKLMMIISQLLVRCCSQSKEFCAKFRSKSEYYNFRQICKLFDNRYSSTVQDRWYLIQLLKFIANEKNGAYAIAMAPGMSKRIIEQLEDENKFLYRAALKLVNSMVAKSFLAGKMSSEQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHU9</accession>
    <name>A0A0N4UHU9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho GTPase-activating protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9879</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHU9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHU9"/>
    <dbReference type="WBParaSite" id="DME_0000714901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000714901-mRNA-1"/>
        <property type="gene ID" value="DME_0000714901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000022">
        <property type="entry name" value="Rho GTPase activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="331"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="496"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000714901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79067" checksum="14C113609550070C" modified="2015-12-09" version="1">MEEDQSLQLQSSSASSSSLPNGIEWVEIVEPQTKQHMYANLRTGQCSWEIPSDVPVKRTQSNQWWELFDTNTQRFYYYNATSMKTVWQRPCNSDIIPLAKLQTLKENTEIPSHSQTDERNTPSATTEVKTKRNSETQTSPKEERRSANRIFTRTVFAQNISPEAGIVTTQRRLSSPHSSLTRRVHRSSPLPLQSNSSCISPLLNSFQEMHIYSNRDCANVQCGSPMIGHISRDDSVESRSSYSHLSNIRPRIMLDSSIPMVPVMPFRSTSAASSAEPPSYNSSSFKIPSSIVNNPVNNRFPVEDVAAKKVVSSGQTTKNIETSNESIVDSWTKDSIKSPVSGCLDDKVLKKEAPTLFKLVQCYMGDRKSKTSPDQLALSLCESGTSKEVLGDELFCQLIKQLTGNEKCDSLRRGWELLAIFLTFMTPSTEEILQRLMRFIDANSDRLLDSPEVPISHYALQCSRRLLRTSSMKQKPTLQLIQESRIHIFSPPQFSAPLEELMELQAEKYPERSISVFNHCFRVLPWLETTLIDLIISSDGQHTEGLFRVPANPDHIHTARLRLDRGLIPVVRDAHVPAALLKLWLRSLPEPLLPDLFYSRCLAVCDQPEEACRIVELLPTINRLVLAKLLDLLQLLAEDETVFHTKMDVCNLAMVMAPNILRCSSNDPRIIFDNARREMTFIKTLILHYDTSFIHSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIK1</accession>
    <name>A0A0N4UIK1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved oligomeric Golgi complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10003</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIK1"/>
    <dbReference type="STRING" id="318479.A0A0N4UIK1"/>
    <dbReference type="WBParaSite" id="DME_0000743401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000743401-mRNA-1"/>
        <property type="gene ID" value="DME_0000743401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5840912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000743401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18920" checksum="3CFCA2070ED87DC5" modified="2015-12-09" version="1">FSVESTKASEISPSFFPFLLEVRKLLSKISSAISPDSAALLYRLINQKIAECFLEIISSTSFNCNGASQMLFDISSSLIPLLNSFYNDGLHNLKALDEPKFNGVITSLRLLSLPKAISLLLFDELKRIPNEMAPSVLAPHNICAMSRDNALNLLKQRCDLNLETDLKITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIN5</accession>
    <name>A0A0N4UIN5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1763</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIN5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIN5"/>
    <dbReference type="WBParaSite" id="DME_0000747001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000747001-mRNA-1"/>
        <property type="gene ID" value="DME_0000747001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10061042at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000747001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="31246" checksum="BCBFAD5AC54E28B0" modified="2015-12-09" version="1">MLKERKRVKINEEIDNLMINEERKDYGSAMEYANEVRKWVYATQCWYYYHQCAWFNAYFHVLNIKQQQQQQQQQQQQQQQERQHTANFTERRRIASFPRRIIAEIIDAFFAFLFQLIIVYFLVEFDYIDIEKYNKLLGDQADLRNLINITQELFPFEVFGKFIISIIEAFFLSYGCGIIQAGSTPGKTFMRIQVISCYGISPVPGSDEYDIIRAQRLSLTSAFCRSIIKNMIINLLFPLSAIAYAFSYNRAVYDLFANTVVVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIQ8</accession>
    <name>A0A0N4UIQ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10087</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIQ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIQ8"/>
    <dbReference type="WBParaSite" id="DME_0000750201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000750201-mRNA-1"/>
        <property type="gene ID" value="DME_0000750201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000750201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40043" checksum="6594B4E1B41B1329" modified="2015-12-09" version="1">FRGLDGFIAAIAPFNFTAIGGNLATAPTLVGNVMLWKPSNSALLSSYIVFKILEEAGMPPGIISFLPANGKDFGAVITNNKYFAGLNFTGSVPTFQNLWLAVANNLHKFISFPKMVGECGGKNFHFVHHSANLDVAAACTVRSAFEYSGQKCSACSRLFVPKSLWPSLREKMMVIQKELKVGDVRDGSIFTSAVIDAQAYDRIISYIEHARSGADGAEIIFGGTYDNSKGFFIQPTLVTVINWDSKLLTEEIFGPLLTAFIYDDNDTMKIVESLRDGTIFGLTGAIFAQDKNFLNTARDKLRDAVGNMYLNDKSTGAVVGQQPFGGSRMSGTNDKAGGPHYVLKWSSPLCIKETLVAMDEWRYPSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJK7</accession>
    <name>A0A0N4UJK7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS2000</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJK7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJK7"/>
    <dbReference type="WBParaSite" id="DME_0000784901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000784901-mRNA-1"/>
        <property type="gene ID" value="DME_0000784901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000031">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="241"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="589"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="818"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN52027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000784901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1130" mass="130416" checksum="A22FF90D7206DD1C" modified="2016-06-08" version="2">MQLAYFYLLTSFFVHSTFTSPQLKLLRDILESYDKKVKPTWDFKKQINVTFSMDLYQILELNEPQQYVLLNAWTIERWNDELLFWHPSDYENITEIRLPHSSIWLPDTTLYNSLVMKDEDSRRLLNAKLITDVEQQAVHVELLYPTIYKFSCLLNLRFFPFDVQVCTMTFSSWTYDQTGIDYFAYSDKIGTSNYLENEGWLILETAVRRKEMKYSCCPNKYTLLYLTIVLRRKPLFYIVNLIIPTSIITLIAIVGFFTTSSTSGTREEKMSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILSMIIVISMGTLASAIIIAIQRRGRLGQRLGPKVVRIAKFFGKLSFTDAPSHLRCSESMLSDSKVISSDSVHIFNELNDKQSSKNKSKYTLNYNYKKKRNPQKHANSPNKCLTDLPASSITMTRSMSTVSTDLEQSYFKPAFQQVLASTDDSQKFSPQTTNGALAPEMDTNILIDDNINNIVILPKSQQIIPKKPINSAAALRQERQYSREEYEWLATIVERCCFIAFVFLFLFMTVGINVIGVINWISADGRTYIDMNDDYQQKQIYIILIEYPSILIANHKNSRYDAKNRPVLNHTLPLKIHLSMSLYQILDVNEPSQNVAINIWMIQLLKQYNLKNRIETCELKSWSDELLDWDPHDYEMINTTIVPHDVLWIPDTYIYNSVIMGQDEIERYTNIKITSRFWEGKKGANCSMLYPALYRISCKIAIKYFPYDQQNCTIIIGSWTNSRKILDYSADESVSMQAYIVNEEWDIVSFNIYRKEHKYACCDDPWVIIEAALVIKRRSFYYVINLIFPTSIITIVSIIGFFTAASTNDDRTEKVNLGITTLLAMSIMMLMVSDQMPSTSDIVPLIAWFYLLIIAIISIGTFFTCFILSVHCRGEYGKLPPSYVRTIFFLHATRWIYISVPIDLVKLWDELNSGPSNLKWKKTIDGKEEPLDEEKNSELLQQVICNPMKKDVEEANEITSQVKTSKTLPSSQINDSLEFATKSPKKSKWSKIARNIGQTKNRSITKKADLTSQNPHKEDPISSIALALSALSEISMVDKDEKKTQVVTMKRKRQCNLEWEFLATILDRLLLIFFVIIVFIVTFGVLITETMAQYHIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJP6</accession>
    <name>A0A0N4UJP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2017</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000042">
        <property type="protein sequence ID" value="VDN52044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJP6"/>
    <dbReference type="WBParaSite" id="DME_0000789201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000789201-mRNA-1"/>
        <property type="gene ID" value="DME_0000789201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834377at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000789201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29026" checksum="B3B626B9D04EF1D2" modified="2015-12-09" version="1">MAINVITGLAVVFGVLWNNHEASIALANPASLLSPEDYDFRIDAQGKLIGAPKRASISIICISWNGLFSNIVKFNKLQVTPIKANAMFFSEISEFFHNGFVNGTINFAQANYPSNPATMVNINLTFPKVVHDRIYRIDILYSGYLTPEYCTNAKRYKEFHYFKMAAGNAYYSKTFKTRNINIIDENRSIIGRTARISAIRQNLSLKNTHCTIIGRLDDEVSIDKDDTLKQLALQFNPGSVNRRIVPILIPKSAFIPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJR3</accession>
    <name>A0A0N4UJR3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2036</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJR3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJR3"/>
    <dbReference type="WBParaSite" id="DME_0000791101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000791101-mRNA-1"/>
        <property type="gene ID" value="DME_0000791101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="6">
        <location>
            <begin position="243"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="517"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000791101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124436" checksum="60A823855353EE17" modified="2015-12-09" version="1">MKETMTSDELKRLETAWNGRESINEDEFFTEVLCHHSIPPFIRTLIYSKFCQGKSRISFQSFVIGIVILTKASTDIRLEFLKNEPGIEDWIDNPPELTSHLFEIHYNFYQVLAGVTHLDEREVEELEKVFGSITDTKLCKLTRNGFNSLVSGAIENYFIDSLFRAFDGNGDNLIDFKELVCGLSASCRGPHMAQLNFVAQMFDSDSDGYLTSQDIDLLYDQLFIVTKLHAQYTSIRMVELYWRILFVGPTIFQALRICLINRIELDSFTEWNIISSEWWKKWQFCLKSDTVVPPITNSTIIASKLKNDWSAKVPSLSKEGAPLIIGLTEGKDYEKLPPCLWRALLRWHGSAVHEGISLPRRVIPLLYVEPFSSTPNKSVIELYPPSLLILRHGTASGGWLQSALDSSLRQLPWCLVSLSRVSTVAELLDLLIQQLRISDSDSVRLWLMEIDGKITRKLLQNDALTLFDLNIVNTAQVLLELRNTDMSWPEEVCRLELSNGDVDINDNEELKYKKGVTGLYNMGNTCYMNSGLQCLSNTRPLTEYFLNGMHKDVLKKLNKSDKGSLALEYGEIIEELWSGKKRNIAPIKLRRAIYAKSSGIFTERCQHDCQEFIAILLDLLHEDLNAVQSKPYVVVKDSDGRPDSVVANEAWEAYLAREKSIISHLFSGQLRSSLTCQICKTVSSRFDAFTCLQLPIPIENLLLIPVVVVKRDGCIPKRYGYRLNSESKISDLKQELAKSSSLPADSLNILCLNRTGQLIKNVSDAIEANENLLSVYPSDSLLYAFELPRSENSQVEKISTVIAAHRKMQYNESYLLGASRGCTIQLFGVPIVLPFSFDKTTGNELYEGVWLQVSRLLIDGSSEHINRTRGINRAIDAGEDIRSGYPFDLRIVGDTFEWCHRCPWSAFCRGCILPQTEQPITKHITALAIDWKPAALYLRYQHSVEFLCRDDDSVLSAWQLHYQPCSLTSCLGDFTNAELLDEEIFCKKCNRKTPTIKNLAIWRLPKILIIHFKRFVYMESSKTWIKSSKVVDFPIQHLDLKEWSSNIESSRSTNHYGAMASGHYIAYAKNQEQWFCFNDSTCQLFFIYFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJT0</accession>
    <name>A0A0N4UJT0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DME_LOCUS2059</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UJT0"/>
    <dbReference type="WBParaSite" id="DME_0000793401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000793401-mRNA-1"/>
        <property type="gene ID" value="DME_0000793401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF19">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000793401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="53372" checksum="5BA5875D37E50397" modified="2015-12-09" version="1">MVLQNMFSALSFLHYRKDDDFVDRLSYFYTSSFLIMMAVLVSFKQFGGRPLECWVPAQFTSSWEAYAEMYCWAQNTYWVPIDQEIPVEISEREYRQISYYQWVPFFLLIQAFLYYIPCLMWRLMSDKSGIKLNDIVQVATEKENIEPEYRIRTIESLSRHIESALRYQHTATSRTQYTLHRVFKCFNLRYYESYVTGLYLATKVMYVGNILTNLILVNKFLETDDYSIYGFGVVRDLLYGRSWMESGNFPRITLCDFEVRVLGNTQRHSVQCVLVINIFNEKIFILIWLWFSILFVAAALDAMYWFSISLFHRDRLRFVLRHLELTTDPDRPELFRKEKRKEVEHFLRTYLKVDGVLILRMIALHAGVMYCTEITDALWKRYLSQHPENLIDENSSLINFARTQTIRRRRELESNSHHSNSFRFPKLFQQRSAVSLRYRLFYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKG3</accession>
    <name>A0A0N4UKG3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2278</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKG3"/>
    <dbReference type="STRING" id="318479.A0A0N4UKG3"/>
    <dbReference type="WBParaSite" id="DME_0000820201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000820201-mRNA-1"/>
        <property type="gene ID" value="DME_0000820201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000820201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27986" checksum="DC108FF73D0D2842" modified="2015-12-09" version="1">MDVNQAIVQVYRSNSNKDDPSLTQIGYSGAQLVGRSLSNKQLNIHTIYTSPSLRCIQTAKSIVSSLNTRRLPRIRIEYALFEPLAFVSKVTFHGIFKDDKVPKFITKEELTNNKFHFDEKYTSVMNYEELKQMFGQEKTITDFYKRVEHAVNRIVGGKRKRGGIIIISHAPVLDCIFRLLTNRTDLPKTAGDLQRLIHNYPRCSVTTLQFFPENLQWENRADIVPPLSYWHMTTMVNIPDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULJ2</accession>
    <name>A0A0N4ULJ2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2583</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULJ2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULJ2"/>
    <dbReference type="WBParaSite" id="DME_0000866801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000866801-mRNA-1"/>
        <property type="gene ID" value="DME_0000866801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF39">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000866801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="58624" checksum="F0C5E127A55D9C61" modified="2015-12-09" version="1">MSLNRRHRRNLADATYETGINTSSEDLYHSDDHYQNTDSDYDVSDRTYANYSELRPSRHLSRRDIERINYRMINERVVEDVTIEFFYKPRTISVLVAICAFLLLPAFLLEDVFSDRNVLNGFLATFVLFIVISALAFPNGPFIRPHPVFWRIVFGISVTYVMLLQFALFQNFADIKSILKWLDPERLNKDKLDEKEYAINCSDVTLERMWSHVDIFAVAHFLGWAIKALLIRHSIICWYISIAWELTEVFFAHLLPNFQECWWDAIILDVLICNGLGIWVGIKCANFFEIRQFHWESVKDIKTTRGKFKRAVLQFTPESWIKVDWYKNCAIRRTLTIYSFVMIWLVSELNTFFLKHIFAVDTSHPLVSFRLALISFISAPTIRQFYMFATDPRIKRMGMQSWVYLAICVLEAAVCVKFGRPQLPPVKITLIVCWIAFMAFGTFACVWLSVWWVRASSLTKPVSVNGCMRQCYIDSSYENLGVIADDVKARRKKLNLFCTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULV4</accession>
    <name>A0A0N4ULV4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterile alpha and TIR motif-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2673</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULV4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULV4"/>
    <dbReference type="WBParaSite" id="DME_0000879701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000879701-mRNA-1"/>
        <property type="gene ID" value="DME_0000879701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000879701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41977" checksum="B65B6CD81B38409C" modified="2015-12-09" version="1">MTIRVSRNSSISIGGFQIHQSSANQPPISAISAITYPSSSTRSVTRTQRMNSARSSKSSLSSMLPLLSRNTGQFTNLVGSVDSSITVRQHIQEQQRLLAMNTKHDLLESVQDRDEKTYPRQDSVLSSAFSMASLPKPSTRLNMQRPYTPRASKIRNRITVEALQMMQGAREVPARQAQKQSASTSGADLVGSPPLSSSLNSFHNVQTLEVSAKIQTNLPQSSEQSIFIQSDNVERTVYQSIQANNSHTDHIHRINVTTENNQHNGQYPINSQELRLRSLINRNRITSNRMHIDNSSKISSLKPGTEIKFELKENSGVGHYVLPESAAVEDDKASFQRSVSQIQAFQVPSPNLQHQYGDRGQQFVQSNAQIVHVSQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMK4</accession>
    <name>A0A0N4UMK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10590</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001227">
        <property type="protein sequence ID" value="VDN60617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMK4"/>
    <dbReference type="WBParaSite" id="DME_0000908601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000908601-mRNA-1"/>
        <property type="gene ID" value="DME_0000908601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848843at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000908601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10531" checksum="A8CBF58872F176F1" modified="2015-12-09" version="1">MSLSRYETYTREQQNAFVNHLLATIYENYEATRRIQSVVEGIHRIVITILVLLVICISIGLIYIVVIGCRRYQAMNRQVLHRPKSEPIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW3</accession>
    <name>A0A0N4UNW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10709</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001238">
        <property type="protein sequence ID" value="VDN60736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNW3"/>
    <dbReference type="WBParaSite" id="DME_0000962401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000962401-mRNA-1"/>
        <property type="gene ID" value="DME_0000962401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF288">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="84"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000962401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23563" checksum="78A35FBCF21644E0" modified="2015-12-09" version="1">MHYGAAEDRWTIPSSLLLAATTVIPVGYGFITPTTRFGRIIVIIYGLIGAPLVLFTITDIGKFMSNYMLKVFSESVSSVFALFFLCAYLLLGALFFAIASQIPYLDALYFSIISVFTIGFGDMNPPVSVFSIIIFIILGVILVTITVEFVGADAIHRIHYMGRYVGKARNIADRIYQVSCFTVYKLIIRDVRFQIIDEFYCIFLSSFGSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW8</accession>
    <name>A0A0N4UNW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hint domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3280</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000119">
        <property type="protein sequence ID" value="VDN53307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNW8"/>
    <dbReference type="WBParaSite" id="DME_0000963001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000963001-mRNA-1"/>
        <property type="gene ID" value="DME_0000963001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001657">
        <property type="entry name" value="Hedgehog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00632">
        <property type="entry name" value="SONICHHOG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hedgehog protein Hint" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000963001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21056" checksum="96D3CDA0C8B6B1EE" modified="2015-12-09" version="1">MSELEIGDYVLVPASKRVLRYERIEMFYHRRPDVRAKFVVIETESGRKLSLTELHLIPSGNCEEMRQNLMDMTDIEEWMHKSRFAYKAQIGEFELKLLTGNCRIYSPMTIEGSIITDGILASCFSQIESHFAQKIVYDILVLIRRGFGFLMTALNDPIQHIPSFINSVHYISHSFVPFVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP98</accession>
    <name>A0A0N4UP98_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3387</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000128">
        <property type="protein sequence ID" value="VDN53414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP98"/>
    <dbReference type="STRING" id="318479.A0A0N4UP98"/>
    <dbReference type="WBParaSite" id="DME_0000977101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000977101-mRNA-1"/>
        <property type="gene ID" value="DME_0000977101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000977101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28493" checksum="A296DC4F7DB93CA9" modified="2015-12-09" version="1">MESLVNSVKSAAISVGEIFTPLLKESKFKETGVLTPEEFIIAGDYLVYNCPTWAWAKAVDESKTRRYLPVNKQFLITRNVPCSRRCIDMDYDAKQEKPIKFFPYFGYVEQKMKKENDVGNGENIIKTRTYDLHITYDKYYQASRFITFLIAKMMFGIAFLSIFHFYFQDHANKTVTIEAHPHLHSTHMASIHPCRHADIMKRLIDQFAQSGKELIIEEYLIIFLKFLQAVIPTIEYDFTRSITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPF6</accession>
    <name>A0A0N4UPF6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3424</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000132">
        <property type="protein sequence ID" value="VDN53451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPF6"/>
    <dbReference type="WBParaSite" id="DME_0000984101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000984101-mRNA-1"/>
        <property type="gene ID" value="DME_0000984101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000984101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10627" checksum="106A06C282F634CB" modified="2015-12-09" version="1">MDTACRHSKGIQICPEHRIIDLEYIDVVLFANSYDEMQIILNNVSATAVKIELIVNVNRTKAFSSYVQEANKMSLFISSLSVEEALDFKYLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPJ4</accession>
    <name>A0A0N4UPJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10788</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001248">
        <property type="protein sequence ID" value="VDN60815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPJ4"/>
    <dbReference type="WBParaSite" id="DME_0000988501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000988501-mRNA-1"/>
        <property type="gene ID" value="DME_0000988501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="235"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000988501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="675" mass="77779" checksum="754A4008A4C8D399" modified="2015-12-09" version="1">MELSNMGLSFLIEKCNLEPCKVDEIIHDAGCRLTGHKCGINMIFKLISQGITYPSISRYCTQRCVCESEEFVAKTFHWSVDYGIMTTTFIPHLWFLDFQYCPRLRYNMDEEITDLGCRLTGFKCGKNMVFVPVEEFFWYCDGGYCSLGKQVFDYGCMLTGLPCGTNMIFDTMNNNSTEFCIQVCKCAANDYTEINGRCHKKGNIADKYFVEKISRKSFMVGQIFDDFGCFSTHVKCGKNMAFSPIVQFHNISGLIWHEKCLQRCSCRNDKYIEHNKECIERTLDSANPVEKSTPTTHQPCFINANCEHGDSIVDRGCKLSGRKCGTNMEFRSFFLNSSMNVCVQHCLCNNESFVSNRKSCTNRNFILVNNFKNRHEELKKKKEEEILLNCLYGNCSLSQEIIDYGCKLEGYSCGSNMAFRIVDKKKLGDTGITKCTMICECANEFYEKEGECIPKGHQSIFHRYSNPCVIRPCVVGEIFFDGGCRLSGHECGRNMIFVPFTHGMMLDSQYCYQRCSCKNEEFIEKFFQCEKIDEIFQENTIYSINSYKYCPQDHHIYGEEIFDEDCHLTGQRCGPNMIFSNVQNLTIACKQRCICEEEYNYDEQYEECVRKWYCEGGYCKFGMAIYDYGCALTDYKCGINMKFITVIENDVGNCIQLCSCIDEHIEMDGKCLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPS2</accession>
    <name>A0A0N4UPS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3512</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000143">
        <property type="protein sequence ID" value="VDN53539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPS2"/>
    <dbReference type="STRING" id="318479.A0A0N4UPS2"/>
    <dbReference type="WBParaSite" id="DME_0000997201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000997201-mRNA-1"/>
        <property type="gene ID" value="DME_0000997201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF3">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="47"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000997201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29309" checksum="C73CCDC5533752F0" modified="2015-12-09" version="1">MSPVQGPFIGIQGISDVDAEKYGKGIHNATDALKDMMELVSTPDFENREGWKRKNSNKTDVVYSKRYSMGKVFTMKTVFDFPLQQAFAEHWENFIDIIHYNKNISDVKVIADLASNVDVVYLRRLCNKRIILELIFVEAILQYAMNDYANIRGREFLICRTFRRVGDEIIEAARSFDLPDVKPNPLKIRGHVVLAGGRFRMHPKESTKTVVDYVMCIDFKGPDIPKAIMDTTIGMFIIQDADYTRKQIDRVKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPT3</accession>
    <name>A0A0N4UPT3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurexin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3523</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000144">
        <property type="protein sequence ID" value="VDN53550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPT3"/>
    <dbReference type="STRING" id="318479.A0A0N4UPT3"/>
    <dbReference type="WBParaSite" id="DME_0000998301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000998301-mRNA-1"/>
        <property type="gene ID" value="DME_0000998301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5989513at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF94">
        <property type="entry name" value="INTESTINAL NEUREXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="378"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="559"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="778"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000998301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="118316" checksum="B22C6E7586B44944" modified="2015-12-09" version="1">MVDYYHFYFYLNYFFSQTSVQEGVLLHGSVFSAVDNRWLGELKLALVYDQLRLNLANLAEISFFNISLSPDKFHEVILQFNYIRNIVYLSLNSKTKWASWNTGEERYIRIGNELFFFSGGNEVGLSGCFREVYIDFFDVIDGYLRNSELVLASHQLQVCQFENVFDSAIEALAQEEPISQEENLLERVYSKRLCGNNEATFCKNHVECIKKNSIPVCICRKGFTGQYCQFSILPWNCDDVLAFGDKEPGIYMIDVDGSGPLPESYLYCDNGHAIIPHNMPNNTLIRSKNSGNLHLHIIYKFSENKTWFTSIGDVKYLRLADDSGSCQCKNGHCGWCNCDGREVATDSAVMYGPFVPITNIFAIHSPNDVRGEVTLGPLICFGSVGHSHNYMITIRNRKDLINIGEWKGNTLSFEFRTFENNVTLISSSDGEVSLLLHGRHLTLVLNGEKMELMPQVRLNDGRWHRITIEIIDGTAHLLINGSNREDIFAVVLFIKSSIALGGGRDGFLGCFRQVRFNGKLLNMENLLHNRTAQIELGCKDKCASYKCEHDSRYINNGSEISFHDSKWGFLKILNPLISDVLKQRIIFSMKTDQKDSLLLYLHDHLNNFIQVKLFFALRNVNIHLSDHSRIVVTLNFNRTIKKCEVVTRVGLEYSRMRWIQIMLFQKFDRIELNIDDEICEIESERILSNDYIENFISSLNFDTIVIPSVSPFKTTESQQYSIMFIGGVPTENYDGRLNPVYRSNLPNLLGCVRGLMIGERLIDMRDRTFWPYFNYEKDIGARFNENSIMQFRIGEVLDKVIFDWSKIGEHSVNFAFSTNDSAKVRQIMKIYFKHNRFLEIILCKNGSLNIRISSLDATYVTTFPYNYSDAYRHFVQIIFSAEKSLTAIVDSVSLTFNSVFAREFSLGNSVIFYIGGLIHEDDHQELSIFDTKKHNYSGCLSNIDINLNVDNMHFEPISYLYKKNERFVSYFSISGDFPVLGRCALFRTPGLLPVVRNDIISPEWDSPFIVEHFEIANADPRKSGENLICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQE1</accession>
    <name>A0A0N4UQE1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3730</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000175">
        <property type="protein sequence ID" value="VDN53757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQE1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQE1"/>
    <dbReference type="WBParaSite" id="DME_0001022501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001022501-mRNA-1"/>
        <property type="gene ID" value="DME_0001022501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001022501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46349" checksum="F7C6220137BE4F1B" modified="2015-12-09" version="1">MTSDDAYEERLINEEYKIWKKNTPFLYDMVMTHALEWPSLTVQWLPDVNRLEGSDYTTHRLILGTHTSDEQNHLVIAKLLLPNDDAQFDASKYDTERGGINRPLPIIEEFGGFGSITGKIDVELKINHEGEVNRARYMPQNPVLLATKSPNSEVFIFDYTKHPSIPSADNMCKPQLRLRGHTKEGYGLSWNSNQVGHLLSASDDMTVCLWDVQAASMHANYLDAKTIFNAHNAVVEDVAWHVLHDSVFGSVGDDHKLMIWDIRNSSSSKPAHTVEAHSAETVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQTPEDAEDGPAELLFIHGGHTAKISDFSWNPNEPWVVCSVSEDNIMQIWQMADNIYNEEENETPPDQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQR7</accession>
    <name>A0A0N4UQR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3842</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000199">
        <property type="protein sequence ID" value="VDN53869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQR7"/>
    <dbReference type="STRING" id="318479.A0A0N4UQR7"/>
    <dbReference type="WBParaSite" id="DME_0001037201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001037201-mRNA-1"/>
        <property type="gene ID" value="DME_0001037201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF127">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001037201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48632" checksum="596A5A7FAEDE4C20" modified="2015-12-09" version="1">MSRNEYIYDETLDEARQILSETRPNDVSTENFREESTTVQVKFVELVRAAWVLKTGSAGEPIEILVKRSTVVSQPNSDDESDYASSDDTAAIPRHTNVRYRHKRGDTWRYDDGISGDDDGRLETWEVKWCVQKYEYLPEWLQDNEFLRHGHRPPLPNFAECFRSIWSLHTETGNIWTHLIGCIAFALLGLWFMIQPDSHIRFQDKVVFSCFFFGAIVCLGMSFTFHTVSCHSLAVVRIFCKLDYLGISLLIVGSFIPWVYYGFYCRREPKITYITMVSVLGVGAAIVSLWDKFSESSYRHVRAAVFVAIGCSGVVPSVHFMITDGLAPLFSEAAFHWILLMGALYICGAVLYATRTPERFFPGKCDIWFQSHQLFHVCVVLAALVHYYGISTMAMIRLKSSCPAESNAIRAFQNIIEGVKKAVHDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQW8</accession>
    <name>A0A0N4UQW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3888</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000209">
        <property type="protein sequence ID" value="VDN53915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UQW8"/>
    <dbReference type="WBParaSite" id="DME_0001043001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001043001-mRNA-1"/>
        <property type="gene ID" value="DME_0001043001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001043001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24127" checksum="0905BF0302412AF5" modified="2015-12-09" version="1">MHPDAWIIGVTFATVAEKEIIDAICENRALIKVSINLRLPEGRHKIENAMIRNGEIKRVLRREQKAAAAAKLETTQMDETVAKHSNDKMKAPTNAPSTKLLTYANANSTLPNDSSAPPATKAKKATTDKSPKSHVVPKKMTASKTLDSNDASKITTKETIATKTEEKKGACEKKEKLTTKIKTTEKEKTTADSKPVSNPYVKPKSTLLKVANFVKLLTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR58</accession>
    <name>A0A0N4UR58_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3964</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000233">
        <property type="protein sequence ID" value="VDN53991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR58"/>
    <dbReference type="WBParaSite" id="DME_0001053001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001053001-mRNA-1"/>
        <property type="gene ID" value="DME_0001053001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7118285at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001053001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7645" checksum="2A09797C629442BB" modified="2015-12-09" version="1">MPRHLTNDAHEWINEIRTVPIYYLAKPQPRERAWRIQRGKKTLLSLTLPAVKYTITFNDSLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM5</accession>
    <name>A0A0N4URM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPCFC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4116</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000305">
        <property type="protein sequence ID" value="VDN54143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM5"/>
    <dbReference type="WBParaSite" id="DME_0001070701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001070701-mRNA-1"/>
        <property type="gene ID" value="DME_0001070701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041083" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001070701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9363" checksum="FB76A26B261847EC" modified="2015-12-09" version="1">MMNFVYLLPLFFISCVSAGDVSINVCNKPLPPPAVPVPQNGAPQQAQEPQYRPTVDPNLCLDLDPACLEVFNLQEAVQTIPAQLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URS0</accession>
    <name>A0A0N4URS0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4154</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000335">
        <property type="protein sequence ID" value="VDN54181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URS0"/>
    <dbReference type="STRING" id="318479.A0A0N4URS0"/>
    <dbReference type="WBParaSite" id="DME_0001075201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001075201-mRNA-1"/>
        <property type="gene ID" value="DME_0001075201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001075201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48287" checksum="0BD11927D99385C6" modified="2015-12-09" version="1">TETIRNCLNPEWCKPIFVDYYFEEVQRVKFEIGPKSGRKYGEIKVIAEEADDEAKETLQLVCAARNLDKKDLFGKSDPFLQIYRINDDGTEYLLHRTEIIKKTLINEKKMQKKWKKYRNSGVLIFHTVAIKREYSFLDFITRGTQLDFSVAIDLTASNGQINKPGSLHYIGDGQPNEYFIAIRAVADICQHYNNTKNFDAMGFGAKIPPHYTAVNHCFPLNLSDSFCVHGVNGLLDAYRFCLPQCILYGPTNFANVVNEAAKTCINYRKDGSRYRILLIITDGAICDFDQTLSAIISASFLPLSIIIIGVGGEDFESMRRLDSDDSLLRYQGRTAQRDIVQFVALRNFLMEKSISGEESSVAIAKLAKEVLAEIPTQLTSYMKINDIQPCQPKDSSGPLKFFQLFDPSPLYPSASPSYLPKASAPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2W7</accession>
    <name>A0A158Q2W7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5346</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2W7"/>
    <dbReference type="STRING" id="318479.A0A158Q2W7"/>
    <dbReference type="WBParaSite" id="DME_0000098601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000098601-mRNA-1"/>
        <property type="gene ID" value="DME_0000098601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835755at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057531">
        <property type="entry name" value="PUMA/OVT1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24423">
        <property type="entry name" value="OVT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24627">
        <property type="entry name" value="PUMA_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="66"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PUMA/OVT1 coiled-coil region" evidence="5">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1921"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1968"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="425"/>
            <end position="828"/>
        </location>
    </feature>
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        <location>
            <begin position="869"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1485"/>
        </location>
    </feature>
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        <location>
            <begin position="1521"/>
            <end position="1562"/>
        </location>
    </feature>
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            <begin position="1596"/>
            <end position="1784"/>
        </location>
    </feature>
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        <location>
            <begin position="1815"/>
            <end position="1849"/>
        </location>
    </feature>
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        <location>
            <begin position="1985"/>
            <end position="2003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24627"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="VDN55373.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000098601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2003" mass="234649" checksum="C4E9AE3C6E36D4F1" modified="2016-06-08" version="1">MEQAKEKAGEVAQTLGIGGEKLRLETEINDKYYDTSIDSSIAFETNAKNLSSVFFDRAQEDLTNYKKRIDENAERQREHADIMADLQRKVEEYRRRFTTMESRITERKIYTESYGIDLPDIKMKDELWSGKFRMIDDMSEEELSMQLSNERRRNEELFAQLEEERLNNNQLLNEIQRLRKHFEISIRDKERIFINRERNIAQHLSEEQRKIMDLWTELKRVRKQCTEYKEQTERDLENQKNEFIKTIHNVTDTMLKMQVSESQKRERPLLSDATGNLEISKDSIIYEAISKFQETGDISEMPRIIRELHLGKGDDVNLQSEILKKYEESVQRIGELEAKDEDSHSKLLILESELKATKERLNDSQNALRRLYDLAREFEHSPDSQKRTRSFSPAKGYVPSSEVVRTVRYVLNARVNDSLVLQRKLNNAEAQINELITHYKSADESCRRLEKQLVEAKREISDRCDQIAELNRKLRNADDFIKTFEDEKANAAAIRRKLEDEIRRLNEHFKKTLAEIEAKAAEEAEERLRTMEDDYKARIAELTRRIDTLMQEHKHLKDEANELSIRNRNMDVEYKTLLQKIDDKDKEIRKLEDSKSMLLKEFDSQRARLDAVTNEIGSLRSNYENANKSSEAHIITLNELKQQRDDIGKQKDNVARELSDLKRNVDDVSKERDDARKAYQRQLADVDRLKAHISDLENQVIDISRQNDELDTQLKANKAKVTSLETYLQAANKEKEKSNAINQKLIKEKSEIMITIQKNETDTSSLKDQAKKLEQEIEKLRNEILLADEREKNANEAYKQQLMLARNLQNELNELRAELEDLQKIKLQSPEVTEVKPLSVEPEKPGDKISIHHDTTIYDITHTHVKEVENKWKIIVERLENEKDDLARQIQGLQEEITVRQDALDRQDKEIEDLHKKLDEQFDKVKLEMVTIQDKYKTDFDTDRDKYNQTIESMNIQIDELRNKLNVAETQLNDTKNRDAQLDRDINDWKERYNKTNEELGRIRDQLNGEIQRLQNDLYSTRNTLKTMESDNDSLKTQLTSSEENCKSLNKTIADQATKLRDSNSQMRHLTEEIDDLKKLRDNYEAELDNATSRLRSLETEYGQIQLDRNNTRGQLEIALKDNDLLKNSISVHEVEIDRLTKKLQQASAELSDRIKDLDQFKFERERVQIALREKAKLVENLNNELQNMDAKINRLRIDFSDTSDKLAVSDAERDSLRVELDRLHQQLQFSKEQLARKTNEYQTVIDELANAHRLSEDGRVNAVHDLEYSKLELGDLQSRLDKADQLLVSMQQNYLRSENERERLADALRRFQSIVNRSIMIRKFQEVIDSDKEKSDACISGKEEQFDIAGLDTNFQALINRIEKLELERNDYREALERMKRRTGDVKLSKRETIIRKIDTREEDAGDKKAFDLRLESAKQLLRSQEEILKQREEEKRDLKSKLVSLEMQIRTKEGQIRHLNDLVKSLRSDLNNANGELRILRDREEQWDACKFHLESKLKDHEAESKKITTLTASFDADRLTLNEKVNKLTMELRQSENKYAELESDADRLRKDLERSTKVENELRVKVDQLNRVTNDHQILRDQITVLIASFQLLNAENELSNLNGRKQQLENELLLARSEVRESKQRNNDAVHRISELQRQLEDMLNDKKRLNDRIQGLEKTVASYRTTETDLRQQISAAANERSSLQNELSDFQRRLLRLENDKRILSDKNEDLEKIRVTLMQRLALLESDKRAIEAMMTDMALQREAIEQSLNSLERENKELHRNCAQLQQQIAQLELENGNRLMSLADKQKEEQDRIVKTVALEKAQMERLIENRERGLKSRIKQLEAQLSALRDQLFSERRRRRDFSDRVYISDLSKTTSVLPAGSIYSGLTFPLNDTFDSYSSFGSYGSPWVDFSTNNEYTKTGSTVITLKESTTRRSRSPGGTGSPFAHDEGMHSYEITRKEESDGKSTHISEEAIVLQPSQELHESGSFDGAQFNRMTSTKSSNTKQVTNMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q310</accession>
    <name>A0A158Q310_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5771</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="DME_0000141101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000141101-mRNA-1"/>
        <property type="gene ID" value="DME_0000141101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000141101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21269" checksum="15832FFD4282E11B" modified="2016-06-08" version="1">MLCFDSWVELPPPSRASSCNSDMSVLDQDSVKDGPRLVTPSTMATLGNALENLKMLPQNKGDWILDWSSHPEARESLIQCTPNQSTPPNSPIPGDMNFVGIFSCGCNTENDYPLFVGFIITHVISFFIGLTAGMHELSQLCNCQSVMDNYRHDEIDQCLMERLEFMGKISKLTLVKPFSFFFPSTFNQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q490</accession>
    <name>A0A158Q490_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8152</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q490"/>
    <dbReference type="STRING" id="318479.A0A158Q490"/>
    <dbReference type="WBParaSite" id="DME_0000426901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000426901-mRNA-1"/>
        <property type="gene ID" value="DME_0000426901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="190"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="454"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000426901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="881" mass="99155" checksum="A7B1A0E6080BA6F6" modified="2016-06-08" version="1">MEVSLDNIVGSVFSNICSIENECMHGGQCEQYTLINDRYEELIGHGTTRIARSLALQYKCICKPNRSGSYCEHKNSHCTDDRKCINGGKCDPDSDKCLCKPSCRNSFKNILYKRIMIKDICGGGKCVNIPGSFKCVCEDKITDTPCENRALSTNLCAFVNCLNGKCISDDGKARCECEIGFEGEQCQFRVRSFRLQSYVEVLLPKKIFDIKIEFKTTLPSALLYYSYTTASLNDFAVIDIINGKIRYSSNVDGVGFSNFAIHEKINDGTWKRIHIEQKWQTLKITLQRCEIDGYCKICDGKNCSAVIVTQLPQLSITNGINIIGSITNTSEIAKRPAQISAIDFIGCMRRIEFNGKDISSLDILTEQSTGNNCSVTRSCQDEHFEMKRCGDGLCKYSDFSDTCICEGGYDAFSCSSAMQPWLLDGGEVHFELSVYMLRQISFISVDLPKALEASDGYRSKRSSLKDIPCEETEYNEGEPFDGVTQWMEIDFRTFHANGIIFTLVENGNYSRIELINGSLHFITIIRGANPIDIQLDGNKSDGKWYRVGLQQSKDQRIVRFNCGDHGKEIYAEAEFPRLISNNVNSIKLGNANDGTSFVGCVRRFIVNNQAQLFDKSEALLQQIFVPVESRRLAKGCTISSEHLPSSLHWNSFWTLPTNLKTNAINNPSMREISSVSSFSAAMRDLQRLCVKRDRPNSSSSTIYASGENLHVPNQHSTPKVTLHSINRQMEKQESNLRQLKHAIRQSRISIHNSALNPSSSECSYDEPIRCRQRHRSNGPQKTDHYRSSPNSEMEYFPLSVENPLSLTPAKQVKHGYSSQSTILEGQYRSDKESDSIKTLRVSRNMVPRMPRSTILDSDSSTDQSIKENRRISTICVPSAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4D9</accession>
    <name>A0A158Q4D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8525</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4D9"/>
    <dbReference type="STRING" id="318479.A0A158Q4D9"/>
    <dbReference type="WBParaSite" id="DME_0000464201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464201-mRNA-1"/>
        <property type="gene ID" value="DME_0000464201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000156">
        <property type="entry name" value="Integrin-linked kinase-associated serine/threonine phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="80"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41134" checksum="3243E2D892E3D655" modified="2016-06-08" version="1">MAAKRKHYVSLGLASLYDDLDSTSNDAESSNNVTKLADNDNNDNDDDKVLSAKKLKEDMKSDMAERFNASNLGAACSKMLLSVCGWRKGEREEMQDAHSLHDHFDVAVNDVKRCAFYAIFDGHAGRNAADYAAKYLPEKLRRKLSNCFDLVSIEKSMKKIFIETYKQIDEQFLIEARKIRPSWKDGTTATTIIIINDTVYCANIGDSKAVVCRSKSPGTFLPLQLTVDHSPIHFEERMRIQKAGGNVKDGRVMGILEVSRSIGDGQFKAYGVICTPDVKKFSITLDDRFIIMACDGLWKSFSSQEAVEFVIKKVEELKVVSKPADKDSLDDPRYSLWEKVADQLAAESVKRGCGDNVSVIIILLSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4I9</accession>
    <name>A0A158Q4I9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PABS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8757</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4I9"/>
    <dbReference type="WBParaSite" id="DME_0000495801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495801-mRNA-1"/>
        <property type="gene ID" value="DME_0000495801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40121" checksum="4909B332306660FE" modified="2016-06-08" version="1">MNNVANILHAPMNGMWLLAELCEISYSCRMIDRNSTSSYWVHVKLKPPHAVCPCKPFIDPADSQYFPKILMKSEEDEILDQFEAKERTTNKLSEDNDGIKSAPTRKSKVKLSLGDRFVIHRKGDLYIVDEVMARPDKKYIEEPIDSSKWPIDHSKLQSPLMQLIVAAAYTTGVVTTNDSVLTDILLIGLGGGSINNYLRYTRNNVNITVVELYEDTVQIAKKYFGLVEDERQRCTVDDGAKFIKKCTEEGTKFNVIILDACTTEPNTGICPCKPFYNLSVAQFFSKALKKSGVLFINYLSLGEREKLPLKTYIICVNTDRQVNYINSNKFHDDMSKYWKKLNFPGEYWLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4S6</accession>
    <name>A0A158Q4S6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 48 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS672</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4S6"/>
    <dbReference type="STRING" id="318479.A0A158Q4S6"/>
    <dbReference type="WBParaSite" id="DME_0000562701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000562701-mRNA-1"/>
        <property type="gene ID" value="DME_0000562701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000562701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="706" mass="80159" checksum="1353D9E7B34DC17F" modified="2016-06-08" version="1">MAIPPVKKRIQVSFVIRDEKEPMHRSAVNCLQYDHQTDRLYSGGSDTIIRIWKTPHIGEYFQQNGRMNDFQESKEKMASLRDLYVQSMEHHTDWVNDMVLCCSVISASSDTTVKVWNAQKGFCMSTLRTHRDYVRALAYARDIEMVASGGFDQLIYLWDVATLTKLTALNNTVTSLRNGNRIISHNSSPFLGLFEEVAHMVNIILANSKMFEASSLTGNKDSIYSLAMNPSGTIIISGSTEKVLRVFDPRSCQKLFKLRGHTDNVKAIVINRDGTQCVSASSDGTIKLWSIGQQCCVSSHKYHSEGVWALQADSNFSFIYSGGRDKQVLRTAINDFKTSQLMFMENAPIQRLQLTDPDRPRAIWTATWNSSIKRWPLPIEGHLAIGMDDDSYNDMKPHIHEPDIVIPGASSIKQQVVLNDKRHIVTKDTDDNVAVWDVLRGKKASDHGKRSMEEVIKENFKKVFVPSWFTVDLKSGMLQITLDESDFFSAWISAKDAGFPERQTDTKINYGGMLLRALFEHWTKSFSETDEESPTHKFNSVPDHTPLILCESSGRPIFRLIVRDAAHDTEAQMLSDFVPPWVLDVVERNQLPKFNKMPFFLLPHPSLGIKLPKKDRLSATEMLQVRKVMEHVYEKILNAANDGSFTDSGGSAAAQILPSSIPANIEERIELYCQEQKLDPEMDLRTVKHFIWKQGGDLLLYYKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4W7</accession>
    <name>A0A158Q4W7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS841</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4W7"/>
    <dbReference type="STRING" id="318479.A0A158Q4W7"/>
    <dbReference type="WBParaSite" id="DME_0000590201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000590201-mRNA-1"/>
        <property type="gene ID" value="DME_0000590201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="14">
        <location>
            <begin position="58"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="455"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000590201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="989" mass="111743" checksum="71CA8DABE63302EF" modified="2016-06-08" version="1">MHAPSNIKHEHVGKPSTSKIQLQQERNSSRSSSRSKSSPEVIEDEKIILKLASPVGGEALTFYWPLRESPGYSEGQEILDVVKNVLSSFPELNFIVRQHCGLNLDAIDKKNFDQMSSLLEAFNKTVPAITQLVRFPELRKDFKLLFCMTISFWFFQRPYNVIKNFSFSQWKGATKPGGEIWSAERADPVLLKQICTRAYNRAVDNVNHLNNHYKAFSSETYGETSYERLRMIIQEITPKERDVFVDLGSGVGQLVIQMAGGSRVRKAVGIEIASLPNKYAQNLVIEFKKWMKWYGKKFRPFEIFKGDFLDERFRELITKEATIIFINNYAFTADLETKIKRELLSDLKDGTRIISTKPYGHVNRSITDRHMNDISAILDVYEMSQCENACSWTGNYVPYYHHTINRAKLEKYFLAQRNPSLKLASNGSDESRRSSTSSKSRDSFRCWSRESSVSLPVRSNTPNIHTSLNRSHTPNVAGRTQITKIRRSISRQSDDDDYAIGPTTRSKWQEYCSTKTKRAHSTAVPVSANDIDPGDAGSEWSNRDSDYVPNKKIRKTGLGRGRPRKINLAKVVIYFVVAGNTKETRNLVHEMTCTVSVQPLLPINHPSIDIISRDLRDLFEMQLERMASPGLLHEIEAEIQSQMQYKSVLQNRIDLLNKQISSLLFSGTQNLYARMKELGIEATTPYALLDNAKEIVKHHKKISAECAALENEVTILELANKQLEMKVFRRNEDPNLVVNINTVPSINPLVASNVSDNYQTLAGYHKKLSAKGSLVCTKSADYSISNDSSAQQSQDSLSSTDLTIQYVVSNASSYAHQVNSGTLGTVKRSRCRPNRGGQSNKRIPSSSVKILSDPKEAEEMEKRIQDIVAKALEVSLRDLIINPKLSKCAEKERRARGEKRRDKLPTVSTLSTSRIATLHRVNEKMQQSSGAVELMEMKMRNVNDSLMKENIECEGSTTLHQSSLAVAKTETDSIRTAEDYGGICIDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4X6</accession>
    <name>A0A158Q4X6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4X6"/>
    <dbReference type="WBParaSite" id="DME_0000597201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000597201-mRNA-1"/>
        <property type="gene ID" value="DME_0000597201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000597201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14313" checksum="D64DD426657F834A" modified="2016-06-08" version="1">MVNENNSSNIDFFDSMRKIFDSVDLNRSGFAPYERLCAKCEDRHFSPQFPPSFFTFVRRFCLPNGCITFESFITAAYQSFTEQNSHNHDVEKRKFGPKMGLIGLDWKTVHNNQSAVTSKNALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q508</accession>
    <name>A0A158Q508_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1089</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q508"/>
    <dbReference type="WBParaSite" id="DME_0000619201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000619201-mRNA-1"/>
        <property type="gene ID" value="DME_0000619201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3535323at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000619201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55063" checksum="743A0314BD0F3D7A" modified="2016-06-08" version="1">MELLTDASDNIINGCIAYCGGPISAIKACPMQLKDGRECVAVSVFHDEEHLVKRNTVDLTDYIQLWLFTNKEGSVVANLSFMLETKVGAILSLAWCPSVRHSTHYTRQIPLSNLLGILAVAGMQGNVLLYRIFTDLFDQNSSDNPIVYRAKPFLSLKNPEVCLNAPIFSLAWTEYEGASKIAAVSAFGFFLYLFFSEFDLFFTGAVLLWDLNNLESSPFLLKVDDWSSPPSHVVFNFPNQLVVSFREKFILIYDYITKEVLLEEGASRTAGAKVASCERLFKGFVSYQCGNVAVHNPTQSFTSHSVSAGCYITCISTEGNFFVVPIINRHEICVWEMAFCPLTGALMSVGGDGRLVVSLNGRIVPHGTQRDVFFKACRVLMTVIRKPNDNNAWLSDTETNEKGSDLKAPATNLELSAQASYLEINFEDIKQECSFYLQPANILIKVTFQCNQFPIQSYSIDLRTESLNVIDISQASGRLAICGGEAGLLIFMPCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5C8</accession>
    <name>A0A158Q5C8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1581</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5C8"/>
    <dbReference type="STRING" id="318479.A0A158Q5C8"/>
    <dbReference type="WBParaSite" id="DME_0000702901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000702901-mRNA-1"/>
        <property type="gene ID" value="DME_0000702901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000702901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35014" checksum="4B57029ADC0266D9" modified="2016-06-08" version="1">MYAKEITGGCGNPELPTNDDISLGRQTILVETLSSKNKSTTDHDDLVKSIKDHILYPIIELLLKKCEMAMFRISSKNFEIDDVIQLLSKLTAFGPTNFGDSELDKFLFNTVIMLRIHLMELAKVAELSNDFKLKYQYILKKKMNHDSVIGITGDSDDDIDMMVSIPLWHSETMQNSMIQKVSHSGEESNFMRDRNIALQMNEDKPSMNHVITDDDQTDYKKKTHLPPKAIEKLKTWLFLHALHPYPSENEKELLAKETGLQLGQVNNWFTNARRRILASATISPIWNAEQGEQCNPNSKKMRKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q601</accession>
    <name>A0A158Q601_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q601"/>
    <dbReference type="STRING" id="318479.A0A158Q601"/>
    <dbReference type="WBParaSite" id="DME_0000872201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000872201-mRNA-1"/>
        <property type="gene ID" value="DME_0000872201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5793798at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636">
        <property type="entry name" value="PROTEIN CBG20488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636:SF2">
        <property type="entry name" value="TRANSCELLULAR CHAPERONE SIGNALING (X)CROSS TISSUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08560">
        <property type="entry name" value="DUF1757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000872201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20817" checksum="05E6328B02CD324D" modified="2016-06-08" version="1">MLDGLKSWFCNFAQFSRALVTPEVLTDIPQPYAEFAIFSCIKGGEISSILGGLIIHPVYRYYLVRKLTPENTTNNSRKIIRNICRRIQGRCLLGGLAIGPIAGFIYIKCCNINEAELKEKCYRIRCHEQNMVWDRSSVAFGFLGWYWRRFQGAVNGISLALVYTILYFTVILIFHLIKISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q697</accession>
    <name>A0A158Q697_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">TWiK family of potassium channels protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3153</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q697"/>
    <dbReference type="STRING" id="318479.A0A158Q697"/>
    <dbReference type="WBParaSite" id="DME_0000947601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000947601-mRNA-1"/>
        <property type="gene ID" value="DME_0000947601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF98">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="295"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN53180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000947601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59407" checksum="8D0F8AAA465E2ECE" modified="2016-06-08" version="1">MLFSYTEIQRSDAGNALDDEEIPMEMDLTADGPPISDDETTDMNKPMDRQSQILMYAKMILPHVGLVILLIVYLLIGATVFHYLEGPNEILTRNQELNTIFELRNNFHEVVWNITVAGDSYISRETFDGLGQQYFDALVVAIFQAYRNQFINENHLLNRTTDNDTLWTYANSIFFATTVITTIGYGNLVPATKFGRIACICFALFGIPLLLVTIADIGKFLSDFLCFLYRTYRAFKRKVRKHSRRISHHVRDRSTPQHSNSSSKAGSMNLDDIGSETESSCQDELRIPVVMVLFVLVAYTAIGGLLFRMWEGWAYFDAFYFCFITMATVGFGDIVPTEQVYMFFTMAYIIFGLALATMCIDLAGTEYIRKIHYLGTKMEDAKGAVISGLQVGEHLLKHTGIEVIRTASGKLVQVRGAVLNSKQARELGVDYILADLDYQQKNILYEPLSQAVQRLIKSNNIKILPDDITEKDGYIVQNKSYDKPGNKLYRTFRRKPNYIQRLIVPSDGKVTVVIPFMLKESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6B2</accession>
    <name>A0A158Q6B2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3263</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000118">
        <property type="protein sequence ID" value="VDN53290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6B2"/>
    <dbReference type="STRING" id="318479.A0A158Q6B2"/>
    <dbReference type="WBParaSite" id="DME_0000959601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000959601-mRNA-1"/>
        <property type="gene ID" value="DME_0000959601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000959601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55258" checksum="8D5AFDE99CC51E90" modified="2016-06-08" version="1">MDSVGIESCSSSRSSLSSPSFNLICETNGNRSDAMDSSNSSEASTSPNQINVESRNCQQRAIRDGSKDEAYWEKRKRNNDAAKRSREKRRVNDMVCFFFKLRKNDHFQIMEQKLIELTKENSLLRSRLDKQNNIEQKQFHPCKNQEIPLHAPHDSVIIARPNFENTANLGHNSFHTFPTTVGPPPNLTTLFPSTIFPTSSNFLNPTPTNNPTTTQMFQICHLQATLAQQYRNQPSSTISIGCGAFQPFYSIREMASVATVSNLTQRNSPDSSINDVNCKYSKNESNDNAEQLDRQTAIVQRQWNGISPISSNAIDPDSKPQSLLGSLLASRRTSPLVQQSQTDVQSGLNSSPPRVNDVRNCLNSLAVNLICTKSDTESMGSPSSNNNSTSDSMNSRSSPSAPLPPNLSNSAIVEALNSAQPNKQYIDRRRRNNEAAKRCRANRRAQFEYRSKRAQQLEQENDELRKEMIRLKHELEQLKAMHAAKNAILRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6C5</accession>
    <name>A0A158Q6C5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3345</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000125">
        <property type="protein sequence ID" value="VDN53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6C5"/>
    <dbReference type="STRING" id="318479.A0A158Q6C5"/>
    <dbReference type="WBParaSite" id="DME_0000972901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000972901-mRNA-1"/>
        <property type="gene ID" value="DME_0000972901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000182">
        <property type="entry name" value="Paired like homeobox 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000972901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30949" checksum="7B501275961934D3" modified="2016-06-08" version="1">MMDYGGYFSAHSAERNALDSSHATNPFHLNASLGFAATNATSTGSTYGANMHQQHFYGHYASSYGQLAETARHLAGTQSVIPPSVVQATSSSSSLSNAGNSSTYRRPDSLQAFFQTGLPYKFYHNQATLLPGTDAMRSNTASLMAGIPSSSFVGAICNNSNPCERRKQRRIRTTFTSGQLKELERAFLETHYPDIYTREDIAMKIDLTEARVQVWFQNRRAKFRKHERLRRIKEEEMATDESVKCNESSSVQKQNIDDQAEINSHNNNIEVEIDNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6E8</accession>
    <name>A0A158Q6E8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CBFD_NFYB_HMF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10798</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001249">
        <property type="protein sequence ID" value="VDN60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6E8"/>
    <dbReference type="STRING" id="318479.A0A158Q6E8"/>
    <dbReference type="WBParaSite" id="DME_0000989501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000989501-mRNA-1"/>
        <property type="gene ID" value="DME_0000989501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000989501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31415" checksum="31E2198B1BE4D2DD" modified="2016-06-08" version="1">MDFERPECGLPCSSSVQAFANNPAPIRKRRFSSAKIQPTRVKKVMQNDEEIGRMVASVPVAVGRAMEHFAEKLLEASALSIQSSSSRTLSPCHMKEAMMRIPHFSFLEPIMREVPLPARVGNEAAWNTELIPQQAVPVFIAPGIVQNPGPSMDLVPAMLPIRPMSVTAPLYVPTNFSNFTGGKRKQNNGKTNQNPEIKPKRGRPRKIKKGEKCVDDGEILVCKAVKMDLSETASSDRSNGVLTLSDSELMPPPALPPLRLQSSKGAYMSGIKFFKVFIIVENCGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPQ4</accession>
    <name>A0A3P7PPQ4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPQ4"/>
    <dbReference type="STRING" id="318479.A0A3P7PPQ4"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF53">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="260" mass="30040" checksum="DBF4377BDBA2031F" modified="2019-02-13" version="1">MRSKSLRSALRMPTRNRSQKSVRFADVIGLNLVQQSYYEKDDTEDLKNVFIVFSIKSTDSTFKFKFKALNKASVRSMTSALVPLNFSNRSQAEISNIIQTQRVSLDSVNFIGMNITGTIDVLNVTMDKRVYVRYTFDAWKTSIDSQAKYSKAIGEDGAIDAFNFLIVLPPTASCEFCIHYNVNGESYWDNNDEKNYIVQVIANKTKKNEESFYCRHSFTILLALLCEKIIFFIRRREEMREKESGLNLVPLVFLHFLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PQY8</accession>
    <name>A0A3P7PQY8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PQY8"/>
    <dbReference type="STRING" id="318479.A0A3P7PQY8"/>
    <dbReference type="OrthoDB" id="4150at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17993" checksum="9598C3D048EF0CAE" modified="2019-02-13" version="1">MAVLLLTVVTRPLGRYKKKDPRKNDELQEDVDFDEIAETVDDGLPVDYKVKTIKAPNRRLETIVKRVAKKGNAMTDKLIFGGKVRLNEEDTNKKKSYNVEQSDIIDVWESAIEDNPSLSKVCRIEVQQYKLMQNGYDIQVKVWNDMIVDNWCHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PRH1</accession>
    <name>A0A3P7PRH1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PRH1"/>
    <dbReference type="STRING" id="318479.A0A3P7PRH1"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="33"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="446" mass="51213" checksum="2AA332F96F900918" modified="2019-02-13" version="1">MQENSMPLADSLKDALNQPPPIATFDEWTKENNGAILPSKIEGNSADNQVIHHQEAALRNYASSECGAKVLLSNKEVENKNAVLNEKARDDYMRNPCERAQSKWFIIELCETIQPTFIVLANFELFSSGPREIRLSASERYPTNDWIILADIIAENSREIQQFPISANGIYAKFIRVELLSHYGNEHYCTLSMIRLLGISMVDEYEAEAQAAISLESPMPSISQVNFLLILIYYFSVVRSSRQNSAVSQIWIFLEKEKKSIFEIKFRKRLSMVFECVSFFIYLADKFLFADIIISNYSVFGVVLIYYCLGQTLPGGSLSHKESIFLKLNKRIGNLELNLSLSNEYLSELSRRYVEQTNDSRKQVEKLKVNQLRREVRKLRKIVSILSLQCVIDKNSENERGVAKASKSVEKESIDDEMSYAQIETHHHLHSNDNLWTVSLNLNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0N4</accession>
    <name>A0A3P7Q0N4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0N4"/>
    <dbReference type="STRING" id="318479.A0A3P7Q0N4"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="6">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="119" mass="13403" checksum="BCFA86478095C77F" modified="2019-02-13" version="1">MFSFQRKVKIQNVFVVENFEDFNEKVVNSPIPVLVDFYADWCGPCQLLGPRIEAKVNGNNGMVLLAKVNVDYAGDLAMDYDVKVVPTVLAFKDGNLVGRFEGDHPDDYLNDFIADIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QL32</accession>
    <name>A0A3P7QL32_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QL32"/>
    <dbReference type="OrthoDB" id="25039at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="208" mass="23859" checksum="D1E49DDAD208499C" modified="2019-02-13" version="1">MLSLWIICQKVALSAYNCIKSEKYSSVFIRAYIPKNEGMVDSNYTQNIYNAHEAGLGTEIYAIPNVNGSKNAYKQVDEIYMSIQQDRISLNRMWLKVTSPIHWPNNQQANTLFIEEFVRRAAVSIENKYWNALGRGYESKTEANFNDFRPFASFTFPSLKTFALMTPICGIVADQIVYPMPVNNIRTSDRFLQKSEKILIGSVKFLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QQY4</accession>
    <name>A0A3P7QQY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QQY4"/>
    <dbReference type="OrthoDB" id="5861055at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="98" mass="12231" checksum="45547C0D7DF573DF" modified="2019-02-13" version="1">MIIFNFKRKFFLSLGFLQLKLPNSYYIIVKYYSYNVLVRLWKGPEHPVNRFRWRIMEYRGELSDEMIRKKRVTQNFYPALQNYLKEYRDKSFAKYLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SB56</accession>
    <name>A0A3P7SB56_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nbr1 FW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SB56"/>
    <dbReference type="STRING" id="318479.A0A3P7SB56"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000199">
        <property type="entry name" value="next to BRCA1 gene 1 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="6">
        <location>
            <begin position="105"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="295" mass="32941" checksum="7776E9FAD62C2A07" modified="2019-02-13" version="1">MFFNCFIGQFFSGMDIDGDVDGILAQELSRMGTNDREIIIKQFQQLIGGNLEQCPETCTFFLEMNNWNLQEAVGSYYDYGANGMTGCPPQYTTHLPSMLFIKDITIGEGESVPPSTRFTKTWRVKNTGAECWPSGCFISFMEGAQLSDVSRLWVASLKPDEEGDISVEMISPADKGIYQSRWQLNTMAGIPFGESIWCIVTVDDMGILDITQKLASAPLDDFSSTSGTCLNSFSPAFIDNKNFELRKDKSQEIEHTDDNNMDNIAFDPPESPNGSSSLYNAVISRLPQVFWESFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SKD4</accession>
    <name>A0A3P7SKD4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS1852</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SKD4"/>
    <dbReference type="STRING" id="318479.A0A3P7SKD4"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="153"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="504"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="709" mass="83065" checksum="64EE9636DCCCE6D0" modified="2019-02-13" version="1">MCKPRIKKKGTYQMLSVLISKKFYGSYKNYISLKNFFYNTVFQKDKRILHSNDLLFRCVSFFNEAKYKDLLLAPRMTDKIASFIIEERPFDDFKHLQRKLYECPRGGLILQAYVDGLENRSVIENILEDCKLQSKKIQCTIHPHQEIGLKWLVLMHKLNLNAILADEMGLGKTIQIIAFLSYLKKESIKGPHLIIVPSSTVENWMYELKSWAPSIKILTYYGTLDERRHLRAMATDNTIDVLLTTYSMVGSKVEDRKFFKRFKINYVIYDEGHLLKNCSTERYKNLMKIHGERKILLTGTPLQNNLVELISLIYFTMTKLFRKYCNDVNQLLNQFQQKAPMMEAKNSMLYESEKIEQAKAILQPYILRRLKSDVLENLPIKHDRIIFCSMIDEQKRIYRDLMWEFKELSAKGKKVVTSKLMQLRQISNHPLLYRSRYTDDRVVKIAKVLCKKEETYYKKNPEHVAEDLSFLSDFAISQLCSKYKSTRKFCLNEDVALISGKFEVFDELLPKIKSQSDKVLIFSQFTAMMDIIEVYLKIRKYKCCRLDGATPVMERQELINKFNSSEDIFVFLLSTKAGGLGINLTTANHIIIHDIDFNPYNDKQAEDRCHRMGQKKEVYVVRLISSGTIEEEMLTIAQKKLQLEKEITGGNINGTKFVSLHEEGKSYLLIIFIRKTRTKRGCMHKKKDKEEKKYVEDIKIVHILQPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SNE6</accession>
    <name>A0A3P7SNE6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SNE6"/>
    <dbReference type="STRING" id="318479.A0A3P7SNE6"/>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="291" mass="30861" checksum="BE47E3D6017FD7F1" modified="2019-02-13" version="1">MSDVGYSTLTRNQLSLIYGKDSPYHDLAALERLSNITGDEYFEKLLMNDIKLIAKSEAIATIKEGNRRKRQTVLSPSILSPSVSSPSKLSPTILSPGVLNPAILSPSILGAVILSPGLFNPSFLSPSMLSPVILSPDGFSPVVLSPSALNPVVLSPGVFSPAVLSPTALSPGALNPGFGSPAVLSPFVLNPALLSPSAMSPLVLSPFAFSPDMLSPSYFSAVILSPSAFSPSFESPSENVTVVLSPSIFNPFIFIPLKSIYITIPPKYLKSLCISPNIEHPAFNVIRRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SSQ4</accession>
    <name>A0A3P7SSQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SSQ4"/>
    <dbReference type="STRING" id="318479.A0A3P7SSQ4"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="86" mass="9598" checksum="3E1DA632D0C82FCA" modified="2019-02-13" version="1">MQAAGFWADFIDPSSGRPYLGQYTNATLMETDERYNDLGFIVKDLGCCKVLEHISWGSKVFVGTIFTDAAMHTQIVKNIVSEFDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SUI5</accession>
    <name>A0A3P7SUI5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000324">
        <property type="protein sequence ID" value="VDN54169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SUI5"/>
    <dbReference type="STRING" id="318479.A0A3P7SUI5"/>
    <dbReference type="OrthoDB" id="154075at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="71" mass="8596" checksum="8EFC499F1C80D7DE" modified="2019-02-13" version="1">MVNFFCISLKLHVFKLRSFECGFNSLGFICRSFSVHFFIMMLMFVIFDLEVIMFLRDLYYAVLLFFLVWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SUL9</accession>
    <name>A0A3P7SUL9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dual specificity Yak1-related kinase mbk-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Minibrain Kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS7685</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Possible role in the function of olfactory neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SUL9"/>
    <dbReference type="STRING" id="318479.A0A3P7SUL9"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="148"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN57712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="528" mass="59949" checksum="DD89620BD41BB0AE" modified="2019-02-13" version="1">MASNNEYSNTYCDITSGQQQQSQSHSHMNFHMANQIPHVVTSNSTIVQQQSTLAATQGMQISQLSALINQEDGNNGSNVDTDNLSSSQVRIYRDPATAPLRKLSVDLIKTYKGINEELLPRSGIYNDGYDDEEHDYIIHLGEIIANRYQIQRHLGKGSFGQVAKAYDKLEKQDVAIKIIKNKKPFHDQAEIEIKLLEMVNSHHSDFRHYVVNLKTHFIWHNHLCLVFELLSYNLYELVKNSNYRGVSLHLTRKFGYQIVTALAFLSSPNLKIIHCDLKPENVLLCNPKRSAIKIIDFGSSCQVGNRIYQYIQSRFYRSPEILLGLPYDAAIDMWSLGCILVELHTGEALFTGSNEFDQLMRIIEVIGMPPKHMLDMASKTKKYFYKNDDGSYMCQRTCGKQYRQPGSRSLSEIIGVDSGGPSGRRLGECGHTPEEYNKFKDLIERILVFDPKTRITPQNALKHCFLNRVNENNSSNNNKNQSVTNNQVVLSPLFQLLISLLVCFSGMGLTGQHFPKIQLESEFLSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U167</accession>
    <name>A0A0N4U167_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4691</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U167"/>
    <dbReference type="WBParaSite" id="DME_0000033101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000033101-mRNA-1"/>
        <property type="gene ID" value="DME_0000033101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000033101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18745" checksum="BEBAD1626EA9A146" modified="2015-12-09" version="1">MGFWLHRPFAIIYAINFDNKSARKLRNNCVIQRKMSKLYKTLIAIFICLSSSSFRSISSLYCYQGTSDLAKRPKNSLICPQRINPLATSCIKIITDHALVIRYCDELGFCTDRRREKQCSTDVSYAKLHGIVCCCDNDFCNFSSRSKGAFFYVVSLIILYIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U171</accession>
    <name>A0A0N4U171_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U171"/>
    <dbReference type="WBParaSite" id="DME_0000033501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000033501-mRNA-1"/>
        <property type="gene ID" value="DME_0000033501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000033501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8575" checksum="2275581710D85034" modified="2015-12-09" version="1">MFVLQHDPAIVAQTSSSSSMIAGAGDDMVASQMQTSTTSRMTTSQSSSGLKYRLFNALGLQQQQQQPQQQQQQPQPTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1L2</accession>
    <name>A0A0N4U1L2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4862</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1L2"/>
    <dbReference type="STRING" id="318479.A0A0N4U1L2"/>
    <dbReference type="WBParaSite" id="DME_0000050201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000050201-mRNA-1"/>
        <property type="gene ID" value="DME_0000050201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10061508at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="264"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000050201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="58347" checksum="6D3D931BAA897AE7" modified="2015-12-09" version="1">MIDEIGKQNRRIDIEGLKTLAIINLFLFHVNHKFFNNGLIGVDIFFVISGYLARMTLKDSLSIRSIKNYIIKRIKRFILPYYFIFWLIIHIRLHSAKESIGYLSFREFTLTKNNIRNECVSEFEHLWSLPIILQFQFLAPFLMSLRLMKMGRLLFVFAALFSFVLYVAQCGRISRNLSEYLWQFLIGSFAYELDGSNNGTEQAEQINTAARPVDRFLLNDTVLAEIIRINEINKLSKYPTIPELKMIEDLPIISKLKRFGFLQGSGNTTVVVFGNSLAMAALYYIVPAFGLHRIRHIKLLSTPGCTPIYNVKSLNNRYRNCPQFFKISMEIIQKMMPDIIFLNFMFIWPFHEPIKDISKDVLQYKLQKTINDMMKYTRRIVFSYDNPYAPNNFPNPEDITTRLAKRLPIDDLNIPFEVFLNNSQNAYRRIGALRCKKCEFVHVYRWLCDTKICHTYDSKTLITYYADKVHFGINGIKFMIPFYKKLVEELYAKEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1W6</accession>
    <name>A0A0N4U1W6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4988</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1W6"/>
    <dbReference type="STRING" id="318479.A0A0N4U1W6"/>
    <dbReference type="WBParaSite" id="DME_0000062801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000062801-mRNA-1"/>
        <property type="gene ID" value="DME_0000062801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1357022at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="123"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000062801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39215" checksum="5AFF6BA3D7019361" modified="2015-12-09" version="1">MLNDFDNRILTFAIDALLKDFEPKDAIPFISSKFIFNENQQEIILNLPRRMNRVLEFIRQYRVSAESLSDLISFFEHYGQPHLANELKKEVSFNDKQVLSKSSYHFLKNSNLPYSISSSVVREKQMTKLRDILIIQSEKGTPSFWIVIHGMAGCGKTCLVIDTLRSYSHQLCQFYTEVIWIHDGRTNSEQLQKYFSDVVILLSNDSLILNGRESNLNLQQLVRNALNYRPNSLILLDDVLLEESVRWFDEFKARIIATTTNLEIFQAVRQQNTLYSMKLHGFSVEEMQFFVSLNKFDGITSSLLDHLFDVTCGHPAIFNIMVKSCKGDVERYHIDSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3P0</accession>
    <name>A0A0N4U3P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCHC-type zinc finger protein CG3800</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5710</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3P0"/>
    <dbReference type="STRING" id="318479.A0A0N4U3P0"/>
    <dbReference type="WBParaSite" id="DME_0000135001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000135001-mRNA-1"/>
        <property type="gene ID" value="DME_0000135001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870588at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000135001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15043" checksum="EE2673ADBC762809" modified="2015-12-09" version="1">MSDEDRCFKCQERGHYARNCPNQGGGRRFGGADGCHSCGQSGHFARECPKQRSSGGRFGRGTRGGQSECYQCGGYGHFARECPSERRGGSDDPKCYNCGKFGHISRDCPDTGTDQSKRCYNCQEIGHISRDCPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3Z2</accession>
    <name>A0A0N4U3Z2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5827</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3Z2"/>
    <dbReference type="STRING" id="318479.A0A0N4U3Z2"/>
    <dbReference type="WBParaSite" id="DME_0000146701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000146701-mRNA-1"/>
        <property type="gene ID" value="DME_0000146701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000146701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33239" checksum="A0731B369BABF1C8" modified="2015-12-09" version="1">MIGYGSEKKADGREMTASEYSQAGLISGVCARCIVQPLDVLKIRFQLQEEPMRGSMRGKYSGLLQASYLIWKEENVVAFWKGHIPAQGLSAVYGIVQFAVFESLTNRAKYIPLANRNRSLTDFVCGGLSGCCAMTAAMPLDVVRTRLIAQGNPKVWIFKMYLKFYRGTIHAIGKIFRCEGVPGFFRGLVPSLVQIAPYTGKTTALYCGALAGAAAKTTLYPLDVIRHRLQMRGFDRRGFGKASQYRSMIGTFIHLITKEHFQGLFKGLSPSLIKAAANSGLCFFFYKVALELIRTIKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3Z4</accession>
    <name>A0A0N4U3Z4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5829</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3Z4"/>
    <dbReference type="WBParaSite" id="DME_0000146901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000146901-mRNA-1"/>
        <property type="gene ID" value="DME_0000146901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5898220at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000146901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10323" checksum="F8A445046CE00301" modified="2015-12-09" version="1">MPINYLSYDGRETVPKLDTIQHCLIQSGKCTTNTSIFLWNAAEAISECLYRKIGNYQARICDDLSSLMSCKCHLPLKVTKQFEKLQLYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U449</accession>
    <name>A0A0N4U449_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5903</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U449"/>
    <dbReference type="STRING" id="318479.A0A0N4U449"/>
    <dbReference type="WBParaSite" id="DME_0000154301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000154301-mRNA-1"/>
        <property type="gene ID" value="DME_0000154301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051571at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000154301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42628" checksum="FDE45B0A0612BE20" modified="2015-12-09" version="1">MEIKVIVNGQERCVSGVTEATTCAQIIYAIANAIDLKGHLFLTEKIGETERRLAPGDCLSNILKMEETTSANVVFTLKQIDDRSNRISLGNFSQQPVVSSSNNLKVVPEICLHLICLLSSPLYCFLNSQQNNKIDDYDKRSNPFRGYFNYSNCSDTMYQQCDYFVGPFTSTSKLLTQQCNATTSFAENFSSTTSLPIFNSRSLKNRPPPPAYHEVIEQKYHSLTRVHATSSTYQLGGKDSPNDDFRNVNLSREELERLVDEQKKIIERQISQLANLVSNDEQRELLQLERQQTNLRFVLDPLRASNWPVRHKQELTKLEEAKKLVAELQLKIQENAKELQKLEELRKKLEEEVANVTKELEQLHVDFVSSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4F7</accession>
    <name>A0A0N4U4F7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6026</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4F7"/>
    <dbReference type="STRING" id="318479.A0A0N4U4F7"/>
    <dbReference type="WBParaSite" id="DME_0000166601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000166601-mRNA-1"/>
        <property type="gene ID" value="DME_0000166601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="231"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000166601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51608" checksum="B822E331F5D79E64" modified="2015-12-09" version="1">MGQQQSGFGGKRDDRSGGDGDKEKKKKYEAPIPTRIGKRKKGGKGPDVAMKLPTVTPHARCRLKLLKYERIKDYLLMEQEFIKNQERLKPQEERQEEERAKVNDLRGTPMAVGNLEEIIDDQHAIVSTVGFFLDYVTINVGSEHYVSIMSFVDKEQLEPGCAVLLNHKTHAVIGVLADDTDPMVSVMKLEKAPQETYADVGGLDQQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGCPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKMVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVLMATNRIDSLDPALIRPGRIDRKIEFPLPDEKTKRRIFQIHTSRMTLADDVDLDEFVASKDELSGADIKVLSQIKAMCTEAGLLALRERRMRVTMDDFKKSKENVLYRKKEGAPEALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4X2</accession>
    <name>A0A0N4U4X2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6222</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4X2"/>
    <dbReference type="STRING" id="318479.A0A0N4U4X2"/>
    <dbReference type="WBParaSite" id="DME_0000186201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000186201-mRNA-1"/>
        <property type="gene ID" value="DME_0000186201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9922095at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039227">
        <property type="entry name" value="GNG13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15936">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O GAMMA-13 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15936:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="6">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000186201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7482" checksum="1DDAD1EB64CB17EC" modified="2015-12-09" version="1">MDKGDMQRSVESLRHQLNIQRIPISQSANEMKRFIEGQQESDPLVNPVDKRFNPWAEKSKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U581</accession>
    <name>A0A0N4U581_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6351</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U581"/>
    <dbReference type="STRING" id="318479.A0A0N4U581"/>
    <dbReference type="WBParaSite" id="DME_0000199101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000199101-mRNA-1"/>
        <property type="gene ID" value="DME_0000199101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000199101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27422" checksum="5FCCC6870F4B5E0C" modified="2015-12-09" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAVKLGSTSIGIRTNEGVILAAEKRATSKLMVNDAIEKVSKVDSHIAVTFAGLIADSRTLVERAQIEAQNFWFTYNRKIRVEDVTMSVANLALQFGDDDVKASMSRPFGVAMLFAGVDQDGPRLFHLDPSGTFIDCLAKSIGAASDGAEQSLKELYFESISLVEAEKVALTILKQVMEEKLTSSNVEIVVITPTKDEKGRKTGRFERLSKEQLETLVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5B5</accession>
    <name>A0A0N4U5B5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6391</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5B5"/>
    <dbReference type="STRING" id="318479.A0A0N4U5B5"/>
    <dbReference type="WBParaSite" id="DME_0000203101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000203101-mRNA-1"/>
        <property type="gene ID" value="DME_0000203101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000203101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24636" checksum="CF2FFD49998602AD" modified="2015-12-09" version="1">MYKSQPENQKDQQKCNETKNKESAGMSNESDCDDDGDVRSSDDDLANSISNESSLHRKKKTRTVFSRQQVSQLEMTFDMKRYLSSQERSHLAATLRLTETQVKIWFQNRRNKWKRQASSDNDSPINIHRNNIFSAHLQQLTHPTDRMSGTRSLSSGLPVAPHPSLPGPVMHPAVLFHSASSGSSTSPRPILNFTSTENAAAAAKFLYDTYGAIAAHVQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P2</accession>
    <name>A0A0N4U5P2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">YqaE/Pmp3 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6537</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P2"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P2"/>
    <dbReference type="WBParaSite" id="DME_0000217701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000217701-mRNA-1"/>
        <property type="gene ID" value="DME_0000217701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000217701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7106" checksum="FD74D7DF61CB5A76" modified="2015-12-09" version="1">MKNNDEQVPFIDNRPIAVEANQCNIHVLINLFLMVFLILPAYIHAIWYCFFRKQPTNQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U786</accession>
    <name>A0A0N4U786_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS65</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U786"/>
    <dbReference type="STRING" id="318479.A0A0N4U786"/>
    <dbReference type="WBParaSite" id="DME_0000283601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000283601-mRNA-1"/>
        <property type="gene ID" value="DME_0000283601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF95">
        <property type="entry name" value="LD34388P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039501" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000283601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36127" checksum="25F4A51A14F9D3F9" modified="2015-12-09" version="1">MKLFYSILFFIILMIINAEREQVQHGAASAKFRSEHISHGRHNLESDHQAVLGSKKMASEFDELPQDESKRRLAVIAHRMDTNGDNFIDEFELSDWIHRSMLSVDKEETDERFVEMDSNRDGFITWEEYIGDAYGDLSVYFKMDVEDERLMREDKSYFEAADRNHDGKLSAEEFDSFNNPENHEFMHDTLIKMTLADKDANNDGKIDLYEFLGETRIDSNSEWYVVEKNRFENDYDVDKNGFLEGVEITNWLIPDLRATAQQEAEHLISNTDKNGDGRLTIDEIVAEYALFVGSEATNYGEKLNEVSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7F2</accession>
    <name>A0A0N4U7F2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS141</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7F2"/>
    <dbReference type="STRING" id="318479.A0A0N4U7F2"/>
    <dbReference type="WBParaSite" id="DME_0000291201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000291201-mRNA-1"/>
        <property type="gene ID" value="DME_0000291201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000291201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20089" checksum="09842F1037D44E1F" modified="2016-06-08" version="2">MLSRISPHLNLTVVRKFASSDKKLPVTRLSDAKLKTFEEFLNETKPIILWRFLKVMDIAGIPEEHMEPRVARIYIPAREATQSAWNNTKTWKIELDNRQRWENPLIGWSSSGDPLSNISMALDFASKEDAIRFCEKNRWNYEVDEPQRRHIKPKSYAANFSWNKRTRVGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7F5</accession>
    <name>A0A0N4U7F5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS144</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7F5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7F5"/>
    <dbReference type="WBParaSite" id="DME_0000291501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000291501-mRNA-1"/>
        <property type="gene ID" value="DME_0000291501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000291501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16217" checksum="670FACC3DDB6274A" modified="2015-12-09" version="1">MMCSRQIEFVVANRLLGILCVTLGDCLFVWIGEKAEMKTLNFSFEKMGMNLLQSLDDIATNFTTKLSRLLPKKQQKAVSDEIIVKKTPKGKLDKAIDEDKPYEDPYLPRHPGNVNPKTGEVGGPAGPEPTRYGDWERKGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7X2</accession>
    <name>A0A0N4U7X2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7267</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7X2"/>
    <dbReference type="STRING" id="318479.A0A0N4U7X2"/>
    <dbReference type="WBParaSite" id="DME_0000310801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000310801-mRNA-1"/>
        <property type="gene ID" value="DME_0000310801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="109"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000310801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29084" checksum="7FCC0A6BCED5B7FB" modified="2015-12-09" version="1">MNQFCCCVDEPVLHDVEMLYVRGRRSVFEIVLEKHGDRARAKYIFGSMKPMRPSYFETGHYTITFIDGSVMTEKILESSASKMDSSDSPSKSIETKSSAKKYGYIVDMQPDLLMPMVSKGVFIGSQDAAMSLKTLRDSSITHIINCATGIPNFFPDHFVYLKIDIFDLPESDIRLHFDKCHNFMRECVLKGGNVLVHCNAGLSRSATVVISYIMHYDGKSLQDALAHVNGLRHVHPNPGFMMQLRDYEQQLQLNSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U847</accession>
    <name>A0A0N4U847_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7354</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U847"/>
    <dbReference type="STRING" id="318479.A0A0N4U847"/>
    <dbReference type="WBParaSite" id="DME_0000319501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000319501-mRNA-1"/>
        <property type="gene ID" value="DME_0000319501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052794">
        <property type="entry name" value="Mito_Ser_Protease_LACTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520:SF1">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="183"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000319501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34196" checksum="CD8365318DA23707" modified="2015-12-09" version="1">MGCQGYRQKFVDKVSRILGKFIDGVSRISGKFVDEVPRTSGKFVDGLPRISGKWVAKDIGKVRRWGVKDIGKVHRWGVKGIGKVHRWGIKDIGKVHRWGIKDIGKVHRWGVKDIGKVRRWGAKDTGKRMNRLGFLCKQAASVAYGLLLVDFAHSTEQNYFGRQDLSYGYGAPQLTAFTIEECRKKIRAFMVRNNIPGLSIGVSFQGIQWTEGFGYADLEQEVPCSSDTVMRIASISKSITSVIAARLVENGMLDLDAPVQEYLKDYPKPKINGKEIEITCRQLLNHTSGIRHYSRKLKAVLMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8D5</accession>
    <name>A0A0N4U8D5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7460</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8D5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8D5"/>
    <dbReference type="WBParaSite" id="DME_0000330101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000330101-mRNA-1"/>
        <property type="gene ID" value="DME_0000330101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000330101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14758" checksum="33BD43F3C81E5619" modified="2015-12-09" version="1">MEILIFPSLILALLINHSFTIVEICWTFSIYLESVAIMPQLFMLSRTGSAETITAHYLFALGIYRGFYILNWIYRYYTEMFYDPIAIVAGVIQTVLYADFFYLYFTRVNNLDISVIRQQKNLALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8H8</accession>
    <name>A0A0N4U8H8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS216</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8H8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8H8"/>
    <dbReference type="WBParaSite" id="DME_0000335001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000335001-mRNA-1"/>
        <property type="gene ID" value="DME_0000335001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991972at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000335001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="42100" checksum="8CD6D2C32AC61833" modified="2015-12-09" version="1">MTVGCTFSLPCDDKKQIYTPEELKGGQRMLQRIIDDLKKEAITYILPMNNVELLQNMIAPFNELMAEGVRPEFLIDACVKKPELFRSLIQKGPSTLATFNLLVDSCGLTYEDSMRFHEEFNAKSLESIQKRINIFSLCNIMSGHQLGLIISQYPAVLFASDDKDIISNIDGLFEYFSKSQVYLFLFTSYFFASSKKFFIGFFQVHKIVLLNPYVLLENFESLEKKLTYFFYCMGLENTDLTECISWPNMSLEEIVMRHEFLVKAGKYVMPDAKKPQLKIENAKFEQIIDYDEEKFVNELGRMTFEEWDVYKCMWQKKNDSKDNEPLFKIVKPSMRKKFERQYKEKREAEYYEYNDGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8T1</accession>
    <name>A0A0N4U8T1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS334</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8T1"/>
    <dbReference type="WBParaSite" id="DME_0000346801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000346801-mRNA-1"/>
        <property type="gene ID" value="DME_0000346801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000346801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33205" checksum="DE85248510CF2904" modified="2015-12-09" version="1">MEKNRVNYSAVNDSKITRYLPLILCTYFTILLFRITCSTFYFSKESFEVHSETADRFISIVKKSGSAEVQLLDFLIITAVGMAFHRIPCVNYDEDSSKDNLISFAKSFPRLVNQIDLKISACFAHDNSNLDDKISFKRNSMEHTLCVHINGKQFSAISSQWPNILDLIIKAKNFLDTQVTNRSNFKVTVFVDKILIHDIRSNLWDHPEINLTFKPLMNPSFETFCLLDHICDSVLLLAKRTVFDWIIAYGNQRGKVFYQEQQEIDNNPQNFDVMHNLNVWIPIKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U949</accession>
    <name>A0A0N4U949_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6 20">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">Mitochondrial translocator assembly and maintenance protein 41 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS7599</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Mitochondrion inner membrane</location>
            <topology evidence="2 20">Peripheral membrane protein</topology>
            <orientation evidence="2 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 20"/>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U949"/>
    <dbReference type="STRING" id="318479.A0A0N4U949"/>
    <dbReference type="WBParaSite" id="DME_0000359401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000359401-mRNA-1"/>
        <property type="gene ID" value="DME_0000359401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 20" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR028840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN57626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000359401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37107" checksum="E60745ABA4F96B51" modified="2015-12-09" version="1">MVNVDELRQLLECIPQDTVGYAFAYGSGAVSQLGEKSDVKMVDFIIVSNNSLKFHEENLQRNPCHYSALRYFGANTLTKLQRNFAARVFYNTHISYKGRLLKYGVVEYEDLERDLLDWRWLYLAGRLHKVVVDIVPPPKTLAAAIHENRISAIALLLLPGTFTLEQFLTMVVSLSYNGDFRMLFGEDKNKIKKIVDGSSQKLAEIFMPILENDTRLTITRTSLFELIKDTNMAAVYHRIQLLPCAILERLQKVWNQRDSKQRDIEEVTFSLARRLDVAHHIDDAISSIVAPSAIRQTVKNFLTAGITRSSLYALSKMLKMFKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U970</accession>
    <name>A0A0N4U970_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Group XV phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7621</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U970"/>
    <dbReference type="STRING" id="318479.A0A0N4U970"/>
    <dbReference type="WBParaSite" id="DME_0000361601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000361601-mRNA-1"/>
        <property type="gene ID" value="DME_0000361601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039888" evidence="1">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000361601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44453" checksum="8333FC3B1B3B58B2" modified="2015-12-09" version="1">MKNLLFIAIFLLFPVEAQRRLAEENGYPVVIVSIVSVPGLGGSQFEAKLTGKPSVVHYFCLKKTDDFFDLWLNLELLPLYVMDCWADNMRLVYNESTGMTSNMPGVEIRVPGFGTTENIEWLDKSKASEGRYFTDIVEMLVAMGYKRGKNLLGAPFDWRRAPNEMADFYSNLKTLIENTYKYNSNRKIVIITHSMGSPVMLYFYNKVVDQAWKDKFIKSHISLGGAWGGAMQIVKLLASGYNMDFFRIILPPSRLRSMQRSFISSIFLFPNSNLWNETEMIARVDKKNYSLANLKEFFMDINYLNGWNQYKEVGKMLGNLEAPNIDIHCIYGYNIKTPEIFEWSKDYFPDYQPMSIYGDGDGTVNRRSLEACARWINKNSGKNVSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9A5</accession>
    <name>A0A0N4U9A5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9A5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9A5"/>
    <dbReference type="WBParaSite" id="DME_0000365501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000365501-mRNA-1"/>
        <property type="gene ID" value="DME_0000365501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873802at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000365501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40356" checksum="D2E4C987CAAA5E42" modified="2015-12-09" version="1">MPTIWLKYIQTITATKKREGEEKAYEYVTEGEHGLFRIIHERKEALITLMRYKDDAEQKLEHSCNPTVKNCQNLSTFTDTKLNKLGQRPRYSLGETALSMLRSNPKLSSDALRSNQHSSQLTISIRKPSIFYTEDHWDSECNVYPTVNSRRNRIKLLKNCPVCFKDSHNYSNNTTKETLLLCKEVKVFNPTQLQRQKKALALFDIEVVASIEVIRIRQTNYGNNSIWNEESNSLPHGFYATEGANNGKRCYSVCNVQELSSGYILVQSKVGLMIAGSGDVSKLCQNDISLQNLVCTAKDNINSELEKFWRLESIGIQESSNDNDDEETLKCFQRTKIHEKGWSLSCVLALEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9A6</accession>
    <name>A0A0N4U9A6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7661</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9A6"/>
    <dbReference type="WBParaSite" id="DME_0000365601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000365601-mRNA-1"/>
        <property type="gene ID" value="DME_0000365601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000365601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7688" checksum="83E8EEF80BAACBC5" modified="2015-12-09" version="1">MPGTFKESNHEIETQIASPDDTEEAIYKYYKTKEIFREASMNEFNKRIPEDDLNGMKKESFFGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9H0</accession>
    <name>A0A0N4U9H0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7743</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9H0"/>
    <dbReference type="WBParaSite" id="DME_0000373801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000373801-mRNA-1"/>
        <property type="gene ID" value="DME_0000373801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424543at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000373801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11624" checksum="21049584560E1D42" modified="2015-12-09" version="1">MANESGEYYEVMPLTTLRYILRIRRADKISQDRIHLRSNTICINNVITECCLRWLGHVLRPSPQELLHIPLLAKPCDGWCQKRGGPIKIRTDTVRKVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9W0</accession>
    <name>A0A0N4U9W0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7905</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9W0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9W0"/>
    <dbReference type="WBParaSite" id="DME_0000390001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000390001-mRNA-1"/>
        <property type="gene ID" value="DME_0000390001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="8">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="9">
        <location>
            <begin position="218"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000390001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47179" checksum="5A83EB8A608B2735" modified="2015-12-09" version="1">MKFENLLGQHGTAVAKRLGWKQGDEEEGWSKKAIDSLMKKLQKHNKEALANLEMALQSEGKQRSDCVTIPRSLDGRLQISHRKALPHVIYCRVYRWPDLQSHHELKAIDDCRYCYESGQKDICINPYHYDRIETTGILPPVLVPRSTEPPPNIIPRPLRMALLPNAQLSTSAMPCNIDFSNFSPTAPYCKPDEPMDTSPTIPPDISTIEVPYEEGKYWATVTYYELNTRVGEQYDVSSPTVEIDGFTDPMGSPNKISLGMLSNVNRNQQIETTRRHIGKGVKLTYVPSQGTLFAECQSEAAIFIQSRNCNYLHNFHPTTVCKITNGISLKIFDMSKFRELLSQATRCHSFDSSYELTKMAIIRMSFVKGWGSEYQRQDVTSTPCWIEIRLHAPLQWLDKVLKQMGPPHNPISSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA48</accession>
    <name>A0A0N4UA48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS366</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA48"/>
    <dbReference type="STRING" id="318479.A0A0N4UA48"/>
    <dbReference type="WBParaSite" id="DME_0000400201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000400201-mRNA-1"/>
        <property type="gene ID" value="DME_0000400201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000400201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22988" checksum="08309EA2217BE85B" modified="2015-12-09" version="1">FQIIGLEGIPVYTQFFLRDQKWYFGWFLCDLWLMVDYVVCLASIYTVLGITIDRYCSVKYPAAYRNWRTPGRVILIIAVVWLIPTILFGLSVFGYDKFTGKRKLKDDECYVQFMTNPILNMGMYISYYWSTLFVMLYLYWGIYRAAKLLAAKNEQKNKRLAILNEMRAPKQDIVSTATGKSSEQDTPPETQNSAHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAW9</accession>
    <name>A0A0N4UAW9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8205</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the meteorin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAW9"/>
    <dbReference type="WBParaSite" id="DME_0000432201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000432201-mRNA-1"/>
        <property type="gene ID" value="DME_0000432201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6092325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051998">
        <property type="entry name" value="Meteorin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593:SF3">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000432201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29445" checksum="AC5FF025A7AAECD0" modified="2015-12-09" version="1">MIYQCLPGGAVGDDPITRINLLCSRGIISWRNPVGAVHVQLKSDQTKSGRNCMKLLAKYPSSTKIHIAENQTLIPLLFGSNYIKCVQNTEIISILIQSSIDVWKTSKVVELTYETVKKPTTKAYKCDQCSKEMIVQTFCTSDFILRNLVPTNGCIVVSKKEEEKKIFIAQIHFGIVNLLCALSVKQYPRSYSKSQNICLEVFQMKDGKSKVDSSENMNGPMNGPVGGGKMNTLIIDENMNGPVDGGNMNGPVDGGNMNGPIKGENIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAY9</accession>
    <name>A0A0N4UAY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3699 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8227</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAY9"/>
    <dbReference type="WBParaSite" id="DME_0000434401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000434401-mRNA-1"/>
        <property type="gene ID" value="DME_0000434401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267517at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000434401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21170" checksum="BD0779C9BD8E0EF9" modified="2015-12-09" version="1">MAENDGQPFDINLPPAHQYLHLREENLLTNADKYEDANVIINVSFLDLSIVLLPTQKFPYFTQAPLQISQFREAANSNSLIALQPIVRERTTNIATLIQVSSFLIRISKFEELNDGVIIEAVGRQRCKMKFTFFHCYSLIDNQVSFKFSMPYGSVLVLEDRELLPFSQLFVPSSCTRLPPKEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBC7</accession>
    <name>A0A0N4UBC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CACTA en-spm transposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8384</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PKI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBC7"/>
    <dbReference type="WBParaSite" id="DME_0000450101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000450101-mRNA-1"/>
        <property type="gene ID" value="DME_0000450101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8556393at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004171">
        <property type="entry name" value="cAMP_dep_PKI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02827">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000450101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8844" checksum="F957348699EEDDAD" modified="2015-12-09" version="1">MCETQEDLLNEFNASARTGRRNAVPEVDVQGIDSEAIKLTERISNMEVCAANDTSSTTNTSNLQTGMPSLDEHFKIRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBN2</accession>
    <name>A0A0N4UBN2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8505</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBN2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBN2"/>
    <dbReference type="WBParaSite" id="DME_0000462201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000462201-mRNA-1"/>
        <property type="gene ID" value="DME_0000462201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF22">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000462201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="56312" checksum="D8C1F80DF5F5B94B" modified="2015-12-09" version="1">SNLGLPLIAKEFPKINRKSEFENFQDDTNWEWNRWSHFAIAYLPHMIAHTILFNLANKYLSQIIVPYIVIIYSLIISSIFFTPWLVCLSLLQGTFVFFIANLVRKRSAVWLSAIPSLYYVLHYTTALASDPFLVLIFVSYTILSYISYNLEAIDGKIREEDNNSWKRYIRMMFYTFYLPYMISLVMTYPEFERRIRERNSKPRQWNKIILFIIRIIFWWLFIEFILHFFYFEAILYDINYAANLPKNEFVSLGMAIGTFFHMKYVVIFGFPSIFAHLDNMQPFDGPICIARVTLYSKMWRYFDRGLYSFFKTYIFVPICAPSFSIGRRIIGVLISFAFVLLWHGCYYHNVVWIILNILGLFVEYTGKAIYMIDSVRKWREENLSDIAFRRILAWLQIIPFIFGIYSNFYFLGGSQVGYLFVQRIWNEETLTLRYPLFILLTLGYFYTQLTIEIDRRIEIRQENKEIKMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBT1</accession>
    <name>A0A0N4UBT1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8567</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBT1"/>
    <dbReference type="WBParaSite" id="DME_0000468401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000468401-mRNA-1"/>
        <property type="gene ID" value="DME_0000468401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824181at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000468401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12425" checksum="56D7EB45538DD3A3" modified="2015-12-09" version="1">MSLPDYTAEHGDYGTIIHTFDTEQNCQVQCQVQCSMHHFSDLMMQRWLCPLKELDKNYILDRTENTTSGFTIFLIICAILMCLLFFIFGINIIRQRLVKSRSINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBX0</accession>
    <name>A0A0N4UBX0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8611</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBX0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBX0"/>
    <dbReference type="WBParaSite" id="DME_0000472801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472801-mRNA-1"/>
        <property type="gene ID" value="DME_0000472801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF127">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21513" checksum="22F671118B9BD977" modified="2015-12-09" version="1">MMRSSGESVQSENHHMQHAMKVWFHGGYNEVILFQFWSVNSYTGLLLSCALIFVMASLYEGIKWFRIHLRMSVSYRTSSNAQKMLEYGVLNGPDSRGDHSEPVVIHNQPRSSFFLFGVYICPFSFATALYLMQLILAYWLMLIVMTYNSWLTAAVVTGAAFGHWLFAILKYLNPQADKLDTFATDACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC94</accession>
    <name>A0A0N4UC94_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RadC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS498</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC94"/>
    <dbReference type="WBParaSite" id="DME_0000487701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000487701-mRNA-1"/>
        <property type="gene ID" value="DME_0000487701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000487701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10026" checksum="6734AE3A0973C588" modified="2015-12-09" version="1">MNTDNDSQIKEISSPDGARRGQPGRDSRATFTQTHAMCKQYYRFALNERTTNAARLFINEVNSSDVSILQIANLQFGRLVGISDIRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDF4</accession>
    <name>A0A0N4UDF4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9162</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDF4"/>
    <dbReference type="WBParaSite" id="DME_0000536301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000536301-mRNA-1"/>
        <property type="gene ID" value="DME_0000536301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818152at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000536301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11610" checksum="50AEBAD87A33B214" modified="2015-12-09" version="1">EECYYAWSERGNPQTCTKSSDCDTKGAICVYSVMNQQHICCQNKENAILPKCPIGEIITNLSLLLCNPGNHVENDQCPQGSECLKSETNFTQNAEQPNYICCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE74</accession>
    <name>A0A0N4UE74_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone chaperone ASF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS708</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE74"/>
    <dbReference type="STRING" id="318479.A0A0N4UE74"/>
    <dbReference type="WBParaSite" id="DME_0000566301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000566301-mRNA-1"/>
        <property type="gene ID" value="DME_0000566301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000566301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15740" checksum="A83F2E263B6C6A6D" modified="2015-12-09" version="1">MSSAITVVDVIVHDNPAGFCDGFKLEVKYESAAFLEDGLEWDLVYVGSAESKKYDQVLASIVIGPVAKGRHQFMLEANSPDASKIPISDILEPTILLLIGSYQKEEFIRICWIVVNEYNDAKLREEPPAIPIIEKVYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEJ6</accession>
    <name>A0A0N4UEJ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS799</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UEJ6"/>
    <dbReference type="WBParaSite" id="DME_0000580501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000580501-mRNA-1"/>
        <property type="gene ID" value="DME_0000580501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872490at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000580501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48096" checksum="EF4C371E3F74F700" modified="2015-12-09" version="1">MDDLCDPEFYLTYGMERPSHSSTTNSIKNCSQSSAVNSVKNHSFDQQKNDFPKALCIDSKPIDFSAAKTSKTVDSSRKPLKEISQRGRLPSVDQIGPILTQSTASLGDIHKENELFRQRHCRSAASVSTYREASSGRLFASDRYDSLTDAENADDWLKNQFKKLKAKRDNNPEVLRRKRQERMLLEELKHVSDDRRIVKGINEQTYSVEGYGQRSDPLVEYHLEEERLHNIKSPYFDHNEHNENFSIRRVVPNKHYSDIVRHKPPTPPPRARSRSPPSSPYPRRSRTRTPGQDHQEMSIYRQERNNIARNDHGQLIIDNNDDNEFSYLRSIVQNDRPSPTNSKRSILKKRNDDISNGTIPVNQRVSSTPVEEWSTTSSNRAPTPAFPVRKETPLPYHPLLFNGATSDNFTAPNYISYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEL9</accession>
    <name>A0A0N4UEL9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS823</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEL9"/>
    <dbReference type="WBParaSite" id="DME_0000582901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000582901-mRNA-1"/>
        <property type="gene ID" value="DME_0000582901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000582901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28212" checksum="5F82EA289F242BBA" modified="2015-12-09" version="1">MSDIQEKSANGGPDVAANSPTSLQNEASIGDIPAADADADKECEVQKVAKSEEKPQEASKDPRENAIAWLNSLLPNAVHKVNYHLLDWAQHLAVEDEGKRRPLPGKNDSVTKNQFLGFLRDGVLLANLANRLQPGTVETIHEDDKARTKENQASNINSFINFVKDKVGLADDQIFTIEDLLEKGKAGYQSVFNTLLQLGLKTQALFEQKGIDVDQLVQVASQVTQTNLIQTILNFFRRARPAQVGFFALIASIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFH4</accession>
    <name>A0A0N4UFH4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1083</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFH4"/>
    <dbReference type="WBParaSite" id="DME_0000618601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000618601-mRNA-1"/>
        <property type="gene ID" value="DME_0000618601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813665at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000618601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27171" checksum="F27E54D37EF5CA5F" modified="2015-12-09" version="1">MNFLLQDIAMDVEASTSDSDELKQRFRCFYKLLDVQTASIIIATLELVYFSYEVFSTFYLFIQTGEQFVLSFSLSLFGLFLAIIAIILLFVAIWTVTPYLLVPHLLMQVAAIFVLFIFTLFCIFMVVVGTSLELRIVNVENSPEGEFALRLHVLMNQTFGISFQIWALIITTGCFFYLQEKAFIKSRCLDTQLDLNIGPSLKPKLKNATIDIKIDDIMKRSAISVINTDATRNTAETDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG34</accession>
    <name>A0A0N4UG34_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9541</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG34"/>
    <dbReference type="STRING" id="318479.A0A0N4UG34"/>
    <dbReference type="WBParaSite" id="DME_0000643001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000643001-mRNA-1"/>
        <property type="gene ID" value="DME_0000643001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720731" evidence="9">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000643001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32240" checksum="5FD82BF59CB101A9" modified="2015-12-09" version="1">MILFILCHLLMAPSQQISIINPNYVCAKDKNCDITAETKNRCNYCRFQKCLRCCWTVERICTSGPSLAKDDSFRTTEIEMREKKISALYKTTFLKTYIFSAIELSISDIENFIEHVVRSFDYAFSNTGMVGDLYHAREHFRLFLYNAAIFNSIEYVNASTNSSFLLALVIKESLAKTDFGEVFLKDYQAEITKIQTFFGGKIRKDLVAVLMLVSCMIGITPTSPIVYSIFDRVTSCLLLILNRLEIEAKLEISVWDVFYYLFHISNEVILKRAFIIFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG75</accession>
    <name>A0A0N4UG75_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9589</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG75"/>
    <dbReference type="WBParaSite" id="DME_0000647801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000647801-mRNA-1"/>
        <property type="gene ID" value="DME_0000647801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000647801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22731" checksum="A209006829FD8BB6" modified="2015-12-09" version="1">MVDTNRILLNNIGDSSDDYWCLDRYEQFSMSNLSMNSDGDNSSNDALGDKLFHRNEIIMNPKASNPGMEYVYCDDRVTIKANYERIHTLLRLILSKSHLESSNRTLLEKAVLGFSIKHDFWIEKLHTDTLIEIASHNQNSIISFANLLAIIAHCCDSPIKYLLPPRIVIGKVRKYHESEIFVSVVFSMEFFKFDGFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGC3</accession>
    <name>A0A0N4UGC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGC3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGC3"/>
    <dbReference type="WBParaSite" id="DME_0000653401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000653401-mRNA-1"/>
        <property type="gene ID" value="DME_0000653401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970825at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF8">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000653401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12043" checksum="0815D07C5378634E" modified="2015-12-09" version="1">MKAFNAGNTAAAANIYDPDGYFMPNGKDPVKGRAGIEAYFKQDMAEGVKSVQIITEEVNGSGDWAFERGSYHLDGTRGTESGAYLLVWKKVNGQWLIHNDCFNVIKPAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGT1</accession>
    <name>A0A0N4UGT1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Signal recognition particle 68 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9742</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGT1"/>
    <dbReference type="STRING" id="318479.A0A0N4UGT1"/>
    <dbReference type="WBParaSite" id="DME_0000671601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000671601-mRNA-1"/>
        <property type="gene ID" value="DME_0000671601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000671601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49881" checksum="BF20A4CD2DCC61FA" modified="2015-12-09" version="1">MAQHRRGHFDELTFASFTTLSILQLIKEAQQKHGLRHADYQRYRGYCSRRIRRIRKSLGFTNLHKSIPKHPAKFIHRKLTADMISEEKYLQIAVFEAERCWSYAMQYKQEIGEDIHSRKRFHVISKLKRAVSHTKSLEAIVKICDQADVATKLESQAYNAWMHGSLFFELKKWKSALDYLRMAKTIYLKLEEAVKVDNMTELYDVKCKEIQAQLRYCEFNCADYMENNEAMSEILSIKLKLGDDDTLQDDFNKLITDVRSKALIDQPGEIYWASKKIIITNVVYDEIFSLQMALYEQILGNIRDVIQSLNDEPKKDETDGVQASMQDILAFLDFIRLSKTVERYLFIIKCARSQERNERPQSLIRLYDTVLENCKEIIKLPGVDNSTDLVDAYSLKVEYYRTLRLVLAIFIHIAYLFKRAQWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGU6</accession>
    <name>A0A0N4UGU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMMECR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1348</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGU6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGU6"/>
    <dbReference type="WBParaSite" id="DME_0000673401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000673401-mRNA-1"/>
        <property type="gene ID" value="DME_0000673401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000673401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20904" checksum="D1610487EF422FE1" modified="2015-12-09" version="1">MTAYCFDLIISVLRNGQTPKIPSCIPNDKYALFVTWKKGCDKRLRGCIGTFNQLVLHKGLHEYALISAFKDSRFDPITLREVDQLHCAVSLLMKFERLDRYWDWTIGVHGIRIEFQENHHIRDAVYLPEVAAEQGWNHVEALDNLLRKGGFKGTITEEVRLKVIIYRFQSDKIAMSHKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH21</accession>
    <name>A0A0N4UH21_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1429</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH21"/>
    <dbReference type="STRING" id="318479.A0A0N4UH21"/>
    <dbReference type="WBParaSite" id="DME_0000681501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000681501-mRNA-1"/>
        <property type="gene ID" value="DME_0000681501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013584at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057945">
        <property type="entry name" value="TPR_ZSWIM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25572">
        <property type="entry name" value="TPR_ZSWIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000681501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1039" mass="118367" checksum="FFDAB5071B189153" modified="2015-12-09" version="1">MVMDRIDLSIDEKIEALDPNDVWLMRAAAGEQEQINTAEVGQRAASGESRHDDQLSFEDSERFEEDSLCSWQSDSDSICHHFRGWNATSHNPFSENNAEKTSCTELSSNIVPDKLIFNQSIFAVLSLSEYAARKTALTFSYDMIESTYNAIIRSYSSQEIAEKTSYSEASSNIVPDKLFMKILLWCFPENEQDIRLYSCLANGSVDEYNKGEYLFGAGAVRDIFQIGYHLSATVKTIVTPCAVPRRMCEAQNLHLHPARLSRSSQNVSIRIDRCRIVSCQCSCSSKSSWCQHIVAACLYRINFPFKVEYRTTIWDSINELNNAQLKKLSLFLINELPRQYLPIAQRLIDQLRIPSSEITEATGAPDPTDGGHEETAIWSLELHSLTANINRILNKFCAPSPVVHCDVQYLSSNPPPVASEWQWLLQPHRSKEPEGLWNLLSITREMFKRRDENALNILHTITMECLASSSVIWWWYQTSLTQSGEWSIISNKTSASFLCNQKAPQFNCASLCDEVVHLWRLAALNPNLSKTQRIQNIANSQGTFIVDRYREQLSRANARFTYQLFPGFLRALEACYVPWNKVKFSDSVGFRSNENCHNFQKVLSTIFTKVHFNVPSKNSLEGRLQSDSTTSISSHTRTRTSFDDTNVRSNSYDNKDKNRSSKKRIKQMRFSRYNNENDHGNILATDPELSAESGQESDDEFRPIIPSDIETVSHYIFDIHDTDEQSLRPFPFGEVQELFCRAQIRYSEWDLMFAHCEGLMAHGFTHEACKLAVEIANKLMSDPPNLVSPPLFTSSCSECETSTHVTNQLSDPKAKKGLLAEIAMGNPCKKLVDQALKTSQLAASTFSRFIVKFRNVFFFKITYSICRILFLVEALMKEQHTRLLAFQLALKALEIPRSPAATNFLEVKLYYYESELTALLRRMEIGSNELKILREHAQNFLETIDSFIASAEPHALPICLAHYLFDQLSNTQSCDKNKRKFTISRQGNISRQKCDEMLGFCVAVGALDLKLMVSETNYPMLSESTRRQQGQLAFIMLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH54</accession>
    <name>A0A0N4UH54_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1471</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH54"/>
    <dbReference type="STRING" id="318479.A0A0N4UH54"/>
    <dbReference type="WBParaSite" id="DME_0000685701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000685701-mRNA-1"/>
        <property type="gene ID" value="DME_0000685701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000685701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22274" checksum="6A413EB98DC6E3D8" modified="2015-12-09" version="1">MFPNSAGLLLPGRLQTRWARVDELINELEIGDRIEFQRTVKTTKRIYSHWAIFLGFHGFHNEGYVCHMSAAEADFSSANLEIFEKAKNCAKVCLQEITLVSRNDLCRINNSLDQLYDPLPISEISNRALNMVGSSNYNILINNCEHFVNYCRYDFKYSGQVIKTATLAVLMTFGASCGPVGAILSCCFGAAFEFFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHH7</accession>
    <name>A0A0N4UHH7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1562</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHH7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHH7"/>
    <dbReference type="WBParaSite" id="DME_0000701001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000701001-mRNA-1"/>
        <property type="gene ID" value="DME_0000701001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872779at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="346"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000701001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="54519" checksum="0116187C1182F085" modified="2015-12-09" version="1">MMQFKLFLQHLWKRNYTWDQSISEEDEKTWKCLIKEWSTNVKELPRCVIHPSEQMQFHVFTDTSSLAYSAAIYVRNYGIQGVKTSLIFAKSRIAPIKGITIPRLELLAIIVGVRAAHFVINQLNLEKVPVTLWSDSKCALHWIHNCSRLLPKFIQNRVEEIRKAKFLFRYIPSKYNPVDIATKGLSSAKLGNYETWWNGPSCKWSRLLRTTAWALKFINSITKGKLSWLHSLSDLQIMPNLPKTRIERTRTFENIGLDYLGPLSIKNETGIVKRWVALFTCFTTRAIHLKLPISKTYVNFEDYVIIRPIDFILPNASLVSQIPYDNDEEEYHLHRLSTKEKFVRYWSNTLKTLDTFWEIWKREYLTSLRERIQREHNSPKGAEVRRPYENEIVLVNEPEIPRGMWKLARIKEIKRGRNGEARNAIIEMPHGKLLSRPINVLYPLEINDNLDNQPPISEESIQEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHQ7</accession>
    <name>A0A0N4UHQ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="20">LIM/homeobox protein Awh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS1625</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHQ7"/>
    <dbReference type="WBParaSite" id="DME_0000709901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000709901-mRNA-1"/>
        <property type="gene ID" value="DME_0000709901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09379">
        <property type="entry name" value="LIM2_AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000023">
        <property type="entry name" value="LIM homeobox 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN51652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000709901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24623" checksum="6EF9CB6CC40D4EDE" modified="2015-12-09" version="1">MTIALLDLIRSVARQFGTKCSSCRRLIQSTDWVRRARNFVYHLACFACDHCKRQLSTGEEFALQDCRLLCKQHYMELIEGETGQQKSKTKRVRTTFAEEQLAVLQTHFQIDSNPDGADLERIATMTGLSKRVTQVWFQNSRARQKKYQVNKKNHRLNSSGRSSADPCSPKSPSCDSNDGMIFPTSVLTSVEDTMVSGQPSILKKMSSETELINHDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHU3</accession>
    <name>A0A0N4UHU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9872</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHU3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHU3"/>
    <dbReference type="WBParaSite" id="DME_0000714201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000714201-mRNA-1"/>
        <property type="gene ID" value="DME_0000714201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000714201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20833" checksum="25348AD9CD8FB34B" modified="2015-12-09" version="1">TSKNLGKFTGSTGVNILSVDQLGPDDPKNSAWVKKDQLKNAKEVTSGVGLKLMQKMGWTPGEGLGKDGAGPLVPLVLDIKADRKGSFNVFGSISIFNYSKNNGLVCIRCKHPVSLLMELCSKKKWSSPQFSCVESGPKHFLLFFILCIERYVEYRPIIPSNSKKLGKAQACQVVLQSLGLVPHDPSLPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI55</accession>
    <name>A0A0N4UI55_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9940</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI55"/>
    <dbReference type="STRING" id="318479.A0A0N4UI55"/>
    <dbReference type="WBParaSite" id="DME_0000727201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000727201-mRNA-1"/>
        <property type="gene ID" value="DME_0000727201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5318at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="260"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000727201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="581" mass="64534" checksum="B2391D892FD02D23" modified="2015-12-09" version="1">MNDNIDVGDSALLSSSSSRSPIGDLSKSRSRSPRSRTLERRDSWLSSSTTKQQFTDTQSQVKCKEIKSPHKFRSKSVEPGSSRLLSPKINSSKPAVKIKSFEIDSTDILEEDNSPLVTASERRLRKEKALGALCIKFVKFAEEYAAKNNGELTLPAVAELMGEERRRIYDIVNVLEALEVLSKKSRCTYFWHGMGQLPNLIAVLAKEAVEQQVAELYKRAEFCMNQMKPLSESEPGQEVVGSWVEVGKNIPVGTRTLHNSVRASLSSLCRRFLIVLLGARTITDEKVHWVSLDIASTILYKDPSKEEYVAPPRARCRRLYDVANVLIALKLIKRGHFIYGTRKTAGFLYCGPEPTKKVSETGSSVQHSTSSHIRYSHSNPTATPNMPDSVQEDSQQKSSLASSENFRSENPLLSGSGSLIQDSSSSSSRPLARIDNIIESDHASARNQNMPPPVFSTLNLAEKRAFNQLNYTLNSPKTFGTQDLSLSPEQLLAYFTCAMQTGQLPVGSAFPGSSVLSLNNFNLPRFFVRILAAFGENFAIEYRCAIIFSLKIHKSGANAILRNNRKCHSSDLSLMREKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIV8</accession>
    <name>A0A0N4UIV8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIV8"/>
    <dbReference type="WBParaSite" id="DME_0000755801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000755801-mRNA-1"/>
        <property type="gene ID" value="DME_0000755801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000755801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10279" checksum="27B6BE043824A11E" modified="2015-12-09" version="1">MISGSDRLCEEFERLNSLCYTNDNNALAESLNLINSLLEKSEGKDINETVEEQEEEEPLLDMWHILTIQLTLVSYFKYCDLKQKFKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ12</accession>
    <name>A0A0N4UJ12_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membralin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1890</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ12"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ12"/>
    <dbReference type="WBParaSite" id="DME_0000762301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000762301-mRNA-1"/>
        <property type="gene ID" value="DME_0000762301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858731at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000762301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28126" checksum="C18D24B99E2A8ED2" modified="2015-12-09" version="1">MEAIMSEVFNDTSTAFYVILLVWIADQYDAICCHSPISKRHWLRFFYLYHYAFYAYHYRYNGQYSGLALLTSSCFIMHSMIYFFHHYEMPLILYQERVQRIITGLQHNPEYQGVLFQSQQRANLGAEQTEGGETMSAQPAQIHWNNNNVPRQASERLILNQPSNVEINLGNRENLLDSTDEEMFSSSISTSTSASSSADFDERHESNLNNSGIDVNDPLLAAGERTAQYIIDSILDSSFVNNLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ39</accession>
    <name>A0A0N4UJ39_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein couch potato</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1920</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ39"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ39"/>
    <dbReference type="WBParaSite" id="DME_0000765301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000765301-mRNA-1"/>
        <property type="gene ID" value="DME_0000765301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000037">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="105"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="342"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000765301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="46971" checksum="59BDBFB6047F5D72" modified="2015-12-09" version="1">MVTVVSVIDDEISDGEKSENKLFFVVSGFFFFLPAAFILLHRNYFFRWRNFTVNITLKRRSRSPSPVVENGQKSLAPSESLDSRLAMSTTTTSAASTVTSPAQVRTLFVSGLPMDAKPRELYLLFRAYPGYESSLLKITSKNGKTATPVGFVTFSSKLAADEARKALQGVRFDPDSTQTIRLELARSNTKVSKPKRITPPPPIMHNPTGLQAAAMFQNAAVAAAAQPNHFLASLSTSHAHDLANAATAACFEPNLSSIFPEHQLFTLSSLSQLTQPHVIFPSNSTVLPQVSTNPAAAAAAAAIFQPNAAILAQLTAAQLNAASQAAAASQAVAVATAPPGCSTLFVANLGSSVTEEELKQVFRSFPGFCRLRMYTKGGSSIAFVEYADIRQATQAMTSLQGFQISGSDRGGMRIEFAKNKMSDINGKSSFYLNIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ40</accession>
    <name>A0A0N4UJ40_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1921</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000037">
        <property type="protein sequence ID" value="VDN51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ40"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ40"/>
    <dbReference type="WBParaSite" id="DME_0000765401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000765401-mRNA-1"/>
        <property type="gene ID" value="DME_0000765401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="5">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000765401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="716" mass="81556" checksum="C2E8C3B8252AB750" modified="2015-12-09" version="1">MDLFNGNFGSFVIGINCGGGESLWGMWVNESVCEERELERESNPRKENVRGLRLVNYVNLDSAPKVKYSRFRHIFAKSVRRSEWYDAGPGHGLAVAANPKMIALAVDVPAGGIIQVAKLMSMGRGNMQMGKIKEHEGPVCDVKWDPFNDNVLATASHDATVRIWHIDDNIRIRCLRILRIHSRRVHTIEWHSTVDNAIISASMDGRIVMWNIESDQIVYVIEGCYAHSFALSYNCSELAVTTKARELIIFDARTGMKLRETEVVHDGIMPSRIVYFDNGLENKLLLTTGSCRNSRRQIAVYDSKKLAKPLSVIDVDSGSGLLMPIVDNDLNLFYVAGKGDSNIRFYELNDEPPFLTYLNESSSHKAHTAVCALPKRGLDVLKCEIMRIYRVDAEQLVIEPLSFIVPRKADSFQVDLYPATRSPTPSLTFREWLAGLDRQPVLIELRDCMLNCTNKPVIFKDSTKHASKLITADINNDRKFRFLSQVTKPDYREISDREDREELQKLEEIRSKIAAELDANKSEVFSDETRIESEPDFFKSASQFPSGENLDLEKMSINMEIEKNACLQNDAVSTKYCGASFSLSDDIIVKSKKEQLQNERKNAISAPNSTREFKKAELNGHSLSICSKKVQKTGKESPRKWNGFSEETFTNVVLELEKELYKCRIHCEKLEKIIRLQQEDIDSLRYEINWKDDRIEFLQSQLIELNNAQSKNPKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJL3</accession>
    <name>A0A0N4UJL3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2006</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJL3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJL3"/>
    <dbReference type="WBParaSite" id="DME_0000785501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000785501-mRNA-1"/>
        <property type="gene ID" value="DME_0000785501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920525at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000785501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20370" checksum="5CA2E7F4408850E3" modified="2015-12-09" version="1">YPTLKQRLESLIKIKTCRKCLKGGHIESNCKNSLKCFYCKKSHNSALCHNRREFRQAVYDASAHIWCILFRFRIMRKVITSDIKKGIFANRITSRRQELHQISLVEGINKGVSEENLQVPFRLSAINYHLESLEVRKNLYVDNVLISAEDKEENLEKYFELKTIFEEASMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJY9</accession>
    <name>A0A0N4UJY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2128</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJY9"/>
    <dbReference type="WBParaSite" id="DME_0000800301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000800301-mRNA-1"/>
        <property type="gene ID" value="DME_0000800301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000800301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21941" checksum="6E0BAB3A881A3C93" modified="2015-12-09" version="1">MTVPIYVGEIAPSHIRGLLLTSFQLMITFGLMASNIIAGLFSYIDPINIGWRLMFAFAAVPAIIQFFGFLFLPESPRWLYGHGKKLDAEKVLKRIYAESIEWVNFELQAISEACEEEETSKKVVGDSSTLLCILKTKHVRKALIIGCSLQAFQQLAGINTIMSSRNSKLYISYPEYISIEVYKTDAGSNSWTSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKB4</accession>
    <name>A0A0N4UKB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000051">
        <property type="protein sequence ID" value="VDN52252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKB4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKB4"/>
    <dbReference type="WBParaSite" id="DME_0000814901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000814901-mRNA-1"/>
        <property type="gene ID" value="DME_0000814901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825915at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00029">
        <property type="entry name" value="Antisense to 16S rRNA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000814901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12905" checksum="6861BC104824C373" modified="2015-12-09" version="1">MGRWMGIIGDSSFSSLSKNLQTNFDTTIVIISRILICFPNTLMILPQVHLRKPCYDFCPVQATAIKAISTRVFPPQIFGFNTAVSAFLETAQSRAATGGVYKGQGRNQRELMTHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKJ1</accession>
    <name>A0A0N4UKJ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein argonaute-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10321</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001211">
        <property type="protein sequence ID" value="VDN60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UKJ1"/>
    <dbReference type="WBParaSite" id="DME_0000826001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000826001-mRNA-1"/>
        <property type="gene ID" value="DME_0000826001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="10">
        <location>
            <begin position="290"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="11">
        <location>
            <begin position="579"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000826001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="921" mass="102813" checksum="D10CDCAEA1AB77C6" modified="2015-12-09" version="1">MVTPGGGGGGNGDGAGGAGNGGNGASGSGGHAPYERSHGALAPGAPIPIHEGALIQGPMPGSFLKETIPSVIFQCPRRPNHGVEGRSIVLRANHFAVRIPGGTIQHYAVEVQPDKCPRRVNREIIGTMIRAYAKVFNNMQPVYDGKRNMYTRDPLPIGRDRVEFEVTLPGDTAVERQFTVAVKWVSNVSLSTLDEAMEGRVRQVPFESVQAIDVILRHLPSMRYTPVGRSFFSPPLAGVAQTQHLQYHSESKLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYRSMPVIDFMAEVLELPLNQLQDRRSLSDAQRVKFTKEIRGLKIEITHCGQMRRKYRVCNVTRRPAQTQTFPLQLESGQNIECTVVKYFYDKYQIQLKYPHLPCLQVGQEQKHTYLPLEVCNIVPGQRCIKKLTDTQTSTMIKATARSAPEREREISNLVRRAEFNADPYAHEFGIAINPAMTEVKGRVLAAPKLLYGGRTKATALPNQGVWDMRGKQFHTGVEVKMWAIACFAQQQHVKENDLRNFTTQLQRISNDAGMPIIGQPCFCKYAVGVDQVEAMFKYLKQTFAGIQLVCVVLPGKTPVYAEVKRVGDTVLGIATQCVQAKNVIKTTPQTLSNLCLKMNVKLGGVNSILLPAVRPRVFSEPVIFLGCDITHPPAGDSRKPSIAAVVGSMDAHPSRYAATVRVQQHRQETINDLVFMVRELLIQFYRNTRFKPTRIIVYRDGVSEGQFFNVLQHELRAMREACMMLERNYQPGITFIAVQKRHHTRLFAVDKKDQVGKAFNIPPGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLTADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDREHDSGEGSQPSGTSEDTTLSNMARAVQVHPDANSVMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKM5</accession>
    <name>A0A0N4UKM5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2-C2_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2329</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKM5"/>
    <dbReference type="STRING" id="318479.A0A0N4UKM5"/>
    <dbReference type="WBParaSite" id="DME_0000829901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000829901-mRNA-1"/>
        <property type="gene ID" value="DME_0000829901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="RPGR-interacting protein 1 first C2" evidence="7">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000829901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11659" checksum="0A6A350D9375CEEB" modified="2015-12-09" version="1">IVTTVIIVIITIITTIITFLLISYNFSGKNEIELHLHRVKLTENALCVFRSARPTMFFSIEFFDFELQTTPMISGAEGILNYWTTYDVIVSNLLIYYLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW8</accession>
    <name>A0A0N4UKW8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2411</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UKW8"/>
    <dbReference type="WBParaSite" id="DME_0000840501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000840501-mRNA-1"/>
        <property type="gene ID" value="DME_0000840501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="12">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000840501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40813" checksum="8F157D0B2E1D9670" modified="2015-12-09" version="1">MPKGESVVTGASDNFSSRTLLITGKDRKWWDISTFSKEDNPNGLACESSFAILFPKYREKYLRECWPLIEKCFGENFLKAELDVLEGTMIVRTTRKTWDPYIIIKARDTLKLLARSVPYEQAIRVLRDDTSSEIIKISSMVSNRERFVKRRARLVGNEGATLKAIELLTQCYIMIQGGTVAAVGPYQGLKDVREIVEDCMNNIHPIYNIKTLMIKRELMKDEKLKNEDWSRFLPKFKKKMQSSQSTNQAKKKKAAKWKKKTIYTPFPPPPVMSKIDKQLESGEYFLNERARLQEKMNAKALKRVDRIAERQKERAAAFIPPDEKPKSKANKKLVDTPLDIKKLKKKVKKLESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULW3</accession>
    <name>A0A0N4ULW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2685</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULW3"/>
    <dbReference type="WBParaSite" id="DME_0000880901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000880901-mRNA-1"/>
        <property type="gene ID" value="DME_0000880901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000880901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16680" checksum="D4C6A3725AC0D701" modified="2015-12-09" version="1">MICAWERLLAKTDQVFANRNFSYLVAELLKEVGPSITITSLTNTIAFGIGALFSPPEVQLFCIANAVAMIFDLLYCITLFAAILLLATKYERSTPTWNKEEILKIEARKQKVKEKFAYKVLRITIKYLNILKFEYSNILKSFLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM87</accession>
    <name>A0A0N4UM87_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10557</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001224">
        <property type="protein sequence ID" value="VDN60584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM87"/>
    <dbReference type="WBParaSite" id="DME_0000894901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000894901-mRNA-1"/>
        <property type="gene ID" value="DME_0000894901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039237" evidence="2">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000894901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19381" checksum="F7F3F2F0C5CC1F14" modified="2015-12-09" version="1">MANILLALLLLLFIDISTSDGEDIKECATGQPPRPTIPPEYCQDVNTNESCDRLNFAIECRNPLLYPIVLARCPKTCGLCDRPGALGRCPDSHPICPQLRLFGNACQDSRIAQMCMESCNITTCLTGDKINRTTTASASLCQDRRTNCLSYAPYCNHPRYSSVLRDVCPRTCRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM95</accession>
    <name>A0A0N4UM95_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 98</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS2788</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM98 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM95"/>
    <dbReference type="STRING" id="318479.A0A0N4UM95"/>
    <dbReference type="WBParaSite" id="DME_0000895901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000895901-mRNA-1"/>
        <property type="gene ID" value="DME_0000895901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978425at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029668">
        <property type="entry name" value="TMEM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN52815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000895901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27573" checksum="84F20259DE1B3A62" modified="2015-12-09" version="1">MDIVVCLALIVLAAVFIFSSFIMFLMCQRRAQFFKEQVSIPLKFSKLRNENSDTVVQLSPLVAQILENNQWIYDVSGLLQHCVAILKLSHSVIEKLAKISLNSINEQLNESILIATHRIMPRFDDLIKTLATKQVDVRLLEARASSLVSASWALALPFTIICPKAVDFLNESLNEMEKHMEALRFVVDHAENYFNDNVDSNSKNSPLHTIIEESFITNHSDRDTDKKSAIAEEAPSDPQVDNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMA4</accession>
    <name>A0A0N4UMA4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10519</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001222">
        <property type="protein sequence ID" value="VDN60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMA4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMA4"/>
    <dbReference type="WBParaSite" id="DME_0000896801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000896801-mRNA-1"/>
        <property type="gene ID" value="DME_0000896801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000896801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15411" checksum="2DC21B9F958ED74A" modified="2015-12-09" version="1">IRNRGRNSSCIDHEVNRNTVNKSISPYPCHGQKGNQVSLVIYFNKSEKLLWYLSKAGEIRRDEYCFDYTGSGAPVIYECHGLKGNQLWEYYHEVNQCQLLELLFSSSKEIETIKKWRLNSDGGLLYETALTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMC9</accession>
    <name>A0A0N4UMC9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2801</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMC9"/>
    <dbReference type="STRING" id="318479.A0A0N4UMC9"/>
    <dbReference type="WBParaSite" id="DME_0000899801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000899801-mRNA-1"/>
        <property type="gene ID" value="DME_0000899801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000899801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10303" checksum="9AA9B008940F7E5F" modified="2015-12-09" version="1">MGEKIEKVEKSEKHVRDYIDEIEQRARTQCENQSLIRNSTPLSEDQLGKLDSTLKRATAFMKKLKNIGADKFIEICRRNCDFISRNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UME5</accession>
    <name>A0A0N4UME5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10562</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001225">
        <property type="protein sequence ID" value="VDN60589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UME5"/>
    <dbReference type="STRING" id="318479.A0A0N4UME5"/>
    <dbReference type="WBParaSite" id="DME_0000901601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000901601-mRNA-1"/>
        <property type="gene ID" value="DME_0000901601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="256"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000901601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91759" checksum="545B0FD01FD25F39" modified="2015-12-09" version="1">KKNSNYKFYRYDPGSNGFFYKSDGNQGWRRKQTSDIDLLALPHHYQTANSIIVATQQQQQPIPGSILSVPTNINNLRVNNRGNNKIMNSSNNSNTQNRMGNGVDYWRKGGNKSDCFYRYPSRLRAFNQHAPPKLTAEQKREFGPLPDWEDPADVTKYDYMQFMDTQFNNLITGIINGHFETNGAPLSGLPNLVMAQPAPPIFRPAPPNIMPHLQTPINLAESRPDGLYVPPDPLNLTTFIVQNGTYSNSNFMQELPFVTLSEYLQQIFFSEYYLSEENLMKDVYLRRNMDKQGYLSLALIANFPRLKSVTGDMNIIVSALKQSVKIDLDVDSQKVPIMRKFFIFYYQQQIRRNGVSTDLAQTVEKKINENYEEQNSCNNQILASNSQQDSQNQNSDISEINNINTSNEQSTPAAVKLASGDIPEDISDAVVKKLIVVTPANLTSTKRQFDRTGDHTSRSKMSHSLSEEIDLGLRRFEDDLWKKSEYSNVNITKVGTVSEEAFKELKGDDNQNEDYQEEPPPKVIPTPNTVPAISSVWTKKALERKAASASPASPLAKQEMARGKVARFYPVTKVNSLPEKPSTPRKQKTRHSNNPPVELSVGWLLGIRSRTTSLNAWPSVTAIPQIPQHPSIRLLEENGFEPQVYTQWRTYCLNQRQHLGYGTTDMNTFFRFLSFFLRDNFNRNMYEEFKKLALEDAAAGYRYGLECLFRFYSYGLERKFRPEIYLDFQRETISDVQRNQLYGLEKFWTFLKHYKHSRRLEVDPFLKCLLAKYKHPNDFAVEVCLLNFLNFCQYPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMM8</accession>
    <name>A0A0N4UMM8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10616</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001229">
        <property type="protein sequence ID" value="VDN60643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMM8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMM8"/>
    <dbReference type="WBParaSite" id="DME_0000911201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000911201-mRNA-1"/>
        <property type="gene ID" value="DME_0000911201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF10">
        <property type="entry name" value="ZGC:110366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000911201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38360" checksum="2541CE60D0F1DC46" modified="2015-12-09" version="1">MKNSLGTTHSGGYHHNSVVYALKDCSYRMIDTAKRYGVERQIGLAIKESGIPRSSIFLATKLWPVDLGNSATHMACKRSCELLGTDYLDLYMIHLPVVPNWFTKPREIQEETWRALEHLYDEGILFNSLSSIMMYNSLNLVNHIEFFSGSIKAIGVSNYSENDLDELLEYCSIKPHVNQCEFHVCYNNKLLIEYCRDEKIVFTGYCPLAKGTILNEEVINAIAKKHNKSAAQICIKWSVQQGIPAIPKSRKFERIAENCQIFDFLLDYEDFNLLSTLPSKKVIRLHNLQEKFLYSDGYKLQEQPLSIPELPNYINDFSGSDPSFLSTSLSNSTGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN45</accession>
    <name>A0A0N4UN45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-Tim10_DDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3032</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000098">
        <property type="protein sequence ID" value="VDN53059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN45"/>
    <dbReference type="WBParaSite" id="DME_0000931001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000931001-mRNA-1"/>
        <property type="gene ID" value="DME_0000931001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000931001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9868" checksum="A260F6EA3EBEC40D" modified="2015-12-09" version="1">MQNQTSALHGLESVKDIGVTNENYMRMIKDFMAQYNRVSEYCFNNCVKDFTCRWSSFCLFFCLFHVFFCFLIGFLVSSILRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UND2</accession>
    <name>A0A0N4UND2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3121</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000106">
        <property type="protein sequence ID" value="VDN53148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UND2"/>
    <dbReference type="STRING" id="318479.A0A0N4UND2"/>
    <dbReference type="WBParaSite" id="DME_0000941001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000941001-mRNA-1"/>
        <property type="gene ID" value="DME_0000941001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="889"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN53148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000941001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="934" mass="108158" checksum="6BC284D5C6B8AD0F" modified="2015-12-09" version="1">MQDEVDMCTILHEANMDGVKHLQSKNRITRLYAWAIIILIFVWMACFQIWSQIQMYVRTPVATNIEALYPKKILFPAVAICNNNQFRLTYITGPTIQNRRSKARINISSTISAENKTVFEKALENAWDMDAVKFLRNAAHWKSRMVLSCIWPNGSKCKSTDFKAVWTLSGLCWAINTDSENPHYVTASGSGNGLKLLLNIEKYERIESCSRYFKTKNLPGLKILIYNQTEIPASSFGGVNVPPGYTMDIPFRVQKRLKYADAGGCVREADDQKSGTIPFDHEDNIGTCPIRNFLRIIEARCNCSMIRAYNNTIYNFCNVDQYFHCVLPTMESDHKSTRNSKCLPACSNVDFIAWQDMNLLPNNILPNLIDTEEEEDVDDMNQNEKLDAGETFYCEEYRLLSEEQVKQIKRSAHRAFEKQSRYQDDIQLRTKRLISKLREATFKLIDLGWGWNDSTYIGAYQRLNESVQCYGEIAVDHSDVIAGILSPPFVKDEVRITNLYREYKADRNRYTTLNDLKENYGEQVDQLVKNMQEISNIISKIWKIYSRSTFKSTTGSGLERMDLILQLVKQYEDGRLQKRAWAEKMQSRSMRHFFEEDFYEGWYNPTIKDFEEDILHTIEEIEDNDLPNFLKLLHNKSGIQMGSLLYFGNISAENDGKFFAFAESLINCTMTHVRNETVQLLKSFKKYVHEFQSAYSNLFKKELPNYLINFDFDSDFVEQNFAMVNIFLHKMNVELWTQHSTYSIWSLACDIGGTLGLFLGASLLTIIELLYSCFHYSLPNRKCQSKTFWEKIIKNYAYLGIAKLNQRWLKKKSQEIIKKKDELEESAVESGLLENYEGEAYGQLNLNTPHFCNVTTYKFPHIDDKESEKNGSSILLESSYHADLMNETKSMDSSDYSPSTFYDTDVQESDRKTSDTSISHAALFLPKEERQSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP60</accession>
    <name>A0A0N4UP60_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AP_endonuc_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3344</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000125">
        <property type="protein sequence ID" value="VDN53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP60"/>
    <dbReference type="STRING" id="318479.A0A0N4UP60"/>
    <dbReference type="WBParaSite" id="DME_0000972801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000972801-mRNA-1"/>
        <property type="gene ID" value="DME_0000972801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="8">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000972801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31381" checksum="B45FD5FCA0EBFFC0" modified="2015-12-09" version="1">MLGVHVSAAGGLEQSIFNAISIGCRSFALFVRNQRTWNCPPLSDATVQRFKNALQKYEYPVDQILPHASYLINPGSSDPTKLEKSRSGMLDECERCEKLGIQLYNFHPGSAVEANSRKECIRTIAATINYIIQRTKSIILVIETMAGQGNTIGGTFEELHEIIDLVSDKNRVGVCIDTCHIFAAGYDIRTKEAYEKTMSEFEKIIGFKYLRGVHLNDSRGILGSKLDRHENIGKGKLTIKAFRFFMEDPRFDGIPLVLETPECDYAEEMIRLYNSVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPJ5</accession>
    <name>A0A0N4UPJ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10789</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001248">
        <property type="protein sequence ID" value="VDN60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPJ5"/>
    <dbReference type="WBParaSite" id="DME_0000988601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000988601-mRNA-1"/>
        <property type="gene ID" value="DME_0000988601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000988601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20353" checksum="0B0C111E536DAEDC" modified="2015-12-09" version="1">MPCGDNMVFQTIKQYGSADKRISWKTKCIQRCSCVNLSLMEKNGKCINQMDVLLGGKTKLAMVTINFPNYELGKAMVDSRCQLIGQKCGINGIYKKLREEKRERVYPNGVKYTTVCILKCICDDEMFEAKSGYCVKKTQSMTNQQIIASTITVDPRNNMVSDIPSSDIFFIIQFGRIQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPN4</accession>
    <name>A0A0N4UPN4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3485</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000139">
        <property type="protein sequence ID" value="VDN53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPN4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPN4"/>
    <dbReference type="WBParaSite" id="DME_0000992801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000992801-mRNA-1"/>
        <property type="gene ID" value="DME_0000992801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF408">
        <property type="entry name" value="SYNTAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000992801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20078" checksum="C2E5BC842B64E529" modified="2016-06-08" version="2">MAATKKFQKILIDFNEDQLKFKEKCRQKITSFLSISGRQLPDDDIDNAIESGQLFDYTKGLILAQRDKKALYDEVKMRHDDILKLEFSIRDLNDLFLDISGEMLNHIESNVESALDYANKAHGKVKEVRKIREGLRKKKIILFIIIIILIVILFIIGSTVFCFYLPFFCKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ25</accession>
    <name>A0A0N4UQ25_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3611</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000156">
        <property type="protein sequence ID" value="VDN53638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ25"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ25"/>
    <dbReference type="WBParaSite" id="DME_0001008901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001008901-mRNA-1"/>
        <property type="gene ID" value="DME_0001008901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001008901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="23125" checksum="335AEF04DB7DD520" modified="2015-12-09" version="1">MNWAISQDRVYKQLNTYYAECIDDTLFTIGVAVAKGDEKRIKPRKPIDYAEIELSWFKGLNWKMHPEWRYCLLNDSDSSLTAEEAFRVYVEQMRHEGALPRLCESRRQLVDRFIFDMKVTNGLIDLWNYNAKTCKKYDYRRQIHIVFLATPSGLIKYWDEIPEDLTYNDPNLVNISQSTKSFGTPSQQQKLVFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQQ2</accession>
    <name>A0A0N4UQQ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10883</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001266">
        <property type="protein sequence ID" value="VDN60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQQ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UQQ2"/>
    <dbReference type="WBParaSite" id="DME_0001035401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001035401-mRNA-1"/>
        <property type="gene ID" value="DME_0001035401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
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    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001035401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19425" checksum="6D6756985B669D7A" modified="2015-12-09" version="1">MGKQSQTTAAVKPKVARRYQTSGKEPAIIMKEATALWWAEATPSKSNIFSVADKATKSNFTQMIWGKSTKVGCSIKQTCNEDNRLHSPFYVDYVVCLFKESGNKVGEPIYDIGNGCNSDNDCTAFSNSRCDRSTSLCELGNKIGEDVYETGLGCSSDSECTQIPNSKCNTDRKLCVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR01</accession>
    <name>A0A0N4UR01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3921</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000219">
        <property type="protein sequence ID" value="VDN53948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR01"/>
    <dbReference type="WBParaSite" id="DME_0001046701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001046701-mRNA-1"/>
        <property type="gene ID" value="DME_0001046701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041076" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001046701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20779" checksum="35C50526E0109133" modified="2015-12-09" version="1">MLFIWVIFLLLFDFGYFAYEEIEECFMEVTVQNEKKKRPNIDPTNNEACQLLIFGRDCKNPNLYPIILARCPATCGLCDQPGALGECPDRSDICPTITALDPSVCNRSNVANMCMKSCNLKTCLSGKCELKELKESILTAGLSDSSTTALACIDSRVNCLSYKPFCNNPRYADVLRRQCCHTCTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR47</accession>
    <name>A0A0N4UR47_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10921</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001276">
        <property type="protein sequence ID" value="VDN60948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR47"/>
    <dbReference type="WBParaSite" id="DME_0001051801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001051801-mRNA-1"/>
        <property type="gene ID" value="DME_0001051801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001051801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17012" checksum="030A2F2FE91B9F19" modified="2015-12-09" version="1">MWSILDCVILCVSVEFRKIPYYEILDCVILCVSVEFRKIPYYEINANAAVVRPSVPVANCQDRDAAACYEIFKPDNPGVTFANNLMPNQNYQVLDKCQQEPYIMLARQMCPWMCATCCMTKEYNCENATTLPSSAATCRDARQHCAAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH8</accession>
    <name>A0A0N4URH8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10944</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001289">
        <property type="protein sequence ID" value="VDN60971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH8"/>
    <dbReference type="WBParaSite" id="DME_0001065901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001065901-mRNA-1"/>
        <property type="gene ID" value="DME_0001065901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039264" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001065901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14853" checksum="A9CDB85AC0F8EDB8" modified="2015-12-09" version="1">MALFTLLLVLASLCHFASGGAMPIDICSMVVPVAGQNPVRRPSLPVENCQDRDPPACFEIFKYGNDEDQIPAENLVPTNDYKVPENCQKAEYRMLARQMCPQKCATCCLTKEYNCQNGNSFWCNLRLIYPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URT1</accession>
    <name>A0A0N4URT1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4166</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000350">
        <property type="protein sequence ID" value="VDN54193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URT1"/>
    <dbReference type="STRING" id="318479.A0A0N4URT1"/>
    <dbReference type="WBParaSite" id="DME_0001076301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001076301-mRNA-1"/>
        <property type="gene ID" value="DME_0001076301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5808075at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001076301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20932" checksum="82F4E53D6BFB5F9D" modified="2015-12-09" version="1">MLDDELNLANKETIHILQNFFQCCAIDGYKDWILADQREFSGAKRQLYASGYKWNHCTSFGCYLPHSCCRNNQINCSPRILFQNLTINTAVGPQRTLQWFHSEGCVDAVRNHLNPLYFLSFSVFNLFLVIVCFMFTQIAATGYYAVEKCAAWEESILPAWIITFFSPHPNKIMQAYIMNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URY0</accession>
    <name>A0A0N4URY0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4211</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000413">
        <property type="protein sequence ID" value="VDN54238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URY0"/>
    <dbReference type="WBParaSite" id="DME_0001081201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001081201-mRNA-1"/>
        <property type="gene ID" value="DME_0001081201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF0">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041720" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001081201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="20616" checksum="112EA2C5FDA23FD9" modified="2015-12-09" version="1">MLLYSFFFISLITGVKSGDNPIAECNKAVGAFQRPTVEPGLCAHIDLPACAAIFPYTDAAVAIASHANPGASYLIPDQCTQPPLKAFAEKNCPSRCAFCCKAKQFNCANDPSAGSLCDTFTLEMCRNPALRTIALTSCPMKCGLCDQPGAGGICPNTLDDAVCTALAPVICLDDKAKNSCQKTCGLRTCLGKFNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2H8</accession>
    <name>A0A158Q2H8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4439</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2H8"/>
    <dbReference type="STRING" id="318479.A0A158Q2H8"/>
    <dbReference type="WBParaSite" id="DME_0000007901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000007901-mRNA-1"/>
        <property type="gene ID" value="DME_0000007901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000007901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34878" checksum="52A972113C0296DE" modified="2016-06-08" version="1">MSSRFIIVVVYAIFSERFMPNVFALPDQLDAFQELLFETPECEDFISNGKLLAVATYKCSPYVCHFPRQLCMRPSNKYKDLTANQCEDIPESCLTAANNGIPIPIVAKTYSTIATSRIPPISISLTTEYKPSQKIAIISSTAENIVKKEGVMERKLKLQQDICDMEQPQGRFCGFTVKVAYNRCSSSFSGPSPLSQILPFFKSRTSGVNGGVTPNPFPYSQFFLATTISQQIVSNRGFFPEAVINAKPNGDDLANKPSILEMISGGISAFVGSGINSGGTHGNSLLNGFDLGQISRIIQTLQVLSNSSSLNNRDSSTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2R2</accession>
    <name>A0A158Q2R2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5023</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2R2"/>
    <dbReference type="STRING" id="318479.A0A158Q2R2"/>
    <dbReference type="WBParaSite" id="DME_0000066301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000066301-mRNA-1"/>
        <property type="gene ID" value="DME_0000066301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000066301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49767" checksum="488E30FF9B2EAB4C" modified="2016-06-08" version="1">MIENSLYVAIQKVGGDHIKICKVARKQEILIQKLRFRFDDAIGQPYGLFEASAGKLRRICPSALNSETVEHHGFSQTDKSTLTESSCETSSADNNRNKTDGGNSSILESNSRPDLALENMQCVAEKLVKNESMIRLSRSRQKVSQEEIHQMKKDGLPAQHLVARLVDGNLSFPERTVYSKKKYIRRKENKHSSRLLILKPSIRLIAQSYYTKDPERIANLRLDLLSHILSLSAVHFGSRCLVFEQCAGLMSAAVIDRLGGYGACIHLHRGSTAQSIPCIDGMNFDSKVRSTFLPLRISTLLNGSIVEPVDDQIDPSNPELPETAFKRRRERLETERIAWKLFISQEIDSFIIISKDVKPIDILQYVWSSLPFASRIVVYSSISEVIIDTFNWLKSRDAIEVQIHDAFLRSHTVLPQNTRPVMQQLVVSGIIISAIKVNPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2U1</accession>
    <name>A0A158Q2U1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Teneurin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5187</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2U1"/>
    <dbReference type="STRING" id="318479.A0A158Q2U1"/>
    <dbReference type="WBParaSite" id="DME_0000082701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000082701-mRNA-1"/>
        <property type="gene ID" value="DME_0000082701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000082701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2562" mass="290192" checksum="0F815C504DD005B1" modified="2016-06-08" version="1">MINATTNLNTSPSALTQCFDSAFYRSNLTTPTKVTLSKSKSRFGSNFIKDARAYGSEYEVKKAVLDVCNNGMDEKERITGICSWKRIAICLFLSLVFSGFIIIFLLLSRDHSRHIFAHSSRSVFPSASGPYVGSRRDLRTEQPPPLLVLPESFELGKTVEGELPSGVIIYTKFSLQHDNRISFNISMGPRAQFVIYGRQTVLPSPTLFDFSDIVRADRLHIRTNSFQRFKRFYPSTVSLLPEIANYHLLLRYSQNFQLYRSVILTHYLVAGRWHLAFLNDGPQHELIHLSVNIASEYKGDEKKENCRHDCMGRGECRNGKCHCFPGYTGSYCEEIYEFLIFALASGIPSLDSCPVLCSGNGIFSGGRCVCHEGFKGIDCDQLSHWCEVPNCNGHGSCNQNGECECDNGWKGKYCSEKDCADPNCGGYGICYDGQCFCASGYGGLNCRELLSAELACALNSQHANEKFDKANENIDAFCNSRGRIDPETNNCRCIPSYHGVNCQLSRCQVECVHGSCGDGVCECLPGWTGIDCRERKCLTGCEEKGFCNNGTCICNKGWNGENCHIQGCHNDCNGNGVCQLFGGIWKCACDSLHFGDSCLLPIENECDDGIDNDNDGLVDCEDSECCRHQSCTANQMCTAVSHPKDILLKLLPTINANFYQQVKFIIQPHSIQQYADERQFNESLVSVVRGRIVAESGTPLIGVRVAEVRHPPLTGFTLSRRDDSGGIFDLMVNGGRVVTLQFMRKPFEKLEKSFYVQWNEIIYVGDIVMRIGSQLSRKNEEEHSKECRLIHSTHEITPVLFPFWLINQYSGQIIASEMSSQLLVDSLTAYDSIQIPGTGDIFLVYDSSRVDKCQSSLLLELLPHVIPDALRLVHLEIYIAGKYFHNVFSAKPNLTYTFAWDQNNIYEQTMNGLVNAKVSVGYEYIGCDKDIVWIRRSVKLEGRKANRFNLGSWTINVHHHYDVINNILEKGDGSRIYLDATSQVLTTVVGNDQQRPISCPFCNEPASNARLFLPQALCTGSDGSLYIGDYNLIRKLTPSGSLITLLELSISDTVHPYYLALNPKTDSLYISLPLRRQVWKINKEANGDLISNYNIAVGDGSICTDTRCGDDGAADNAQLSFPKGIVFDFEGNLYVIDSRRLSRFRVINGDNQIRTLLMDQKYEPRSCTASNINVTDLKLEWPTSLAFDGQSNSLLVLDSNLVYRISLLTKITSIVIGSLPECEYLKKQDGSIISSHPLIDAKAIAVSPDSTLYIAETNSKRLNQVRALTVDGRLRIIAGRPSKCDCDRLNCPCENVVPTVGHSSFLHSPVAIAVDQSGTLFIADQGNYKIKSLQRLRAFYNPVTRQYRLNSVHTNEVYFFNKNGLHVSTRSLLSALELYNFTYNVDTNLGRLTQITDSGGYSLRIRRINDTETVLESSSGQRTILTFDGFDRTLIRITLPNSSCVKFSYLSGQFLLSKTINSQIWWYEYDELGRAISLINPFGQQITIEEQRFEQGRLITHVYFDGESHSNHSFAIDEFSESGFDNRRAILLSDGIVIESLGSKIYFDSVTHPLLDPHESALLKRKILLPKIDEPHRRELTMRFEWRGYIRRKSRNETRELSRRVLQVGRRPRINGRNFFTIEFNREKNFDIVRNNLDEEIMFIEYNDAGLIVAVKPSNRIRIAHLLLTYDLQGRIKKAKWANSTIDFSYDRRNRITQLAMGPSADLLQRKFLYAKDSHSAPNTVLMPSGEKYHWRYDLSGRVISLKTPSGDIQHYSEHSAINRLIRSRQPSFTNSSFLTSFVDKNLMIEYSTPGGTHSLTFQRDIYGRITQISADSDNIVLHYSQDNGQTQVDSIITLRFFGFIKDTFPEGILKDILKQFSTCYEYDDFFRISSIAASFDSYSLPVLRFEYDARYGRLAKMENFAYLRDGRTRRLLGESVLIESIYDEMDQEKIRKVMIGDERVLEMSIEYHILGWVESVDWVILGSKRPSEKRNYNMDGQLVQYTMGEADDQRWTLHYDLDGRLKAFNDIKVVLGPGGIPQVFGQVVYNIDGNGWTLKRGDLYFTADVYGCIRRAYKVGSIDIEYGYDEQQKVIWRRVGDDIVHRFFYAFPHRPRLISHFLSLQDKSISSILYDENDVPVIMRQSDSYFLILTDADNSVRFIFGSNGSLVKEIIRNPLGATVSDSNPSFYFPLGYLSQFDDPTVGIVMVGDDSRPLDTVIGRFMTTPVAYASSLVDVFNPEFEADPYKLNFIRANVPRKIPNSIDEWMHKMGFHLSYIVPSLSIAPNTAQIVRFLWESPADLCSPIYSSGLSAAFCSLLSKAIHFKQFSTVAKSGMLQLSQIPLLSPIQKVAYSRNDSIGFHELLFIRHRNNSVNFNEMGRWNFIYHVIFSKVLVDKRHGLYVCLLARVRIRSPNPDDSDVVKILNGLFANSTLIKNDEFGLLPISSTILSEVHFATRLSQVNEATYNQLMPFFNVTTHSNELHLIAGRTQIVLHLEADPEHVRAEIIRQRSKYIESLIWENEATAARDGALTRYSWSQTELNELISKGDVDCYSLLFNPGHSIAVLSNQKLWKFIKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q364</accession>
    <name>A0A158Q364_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cardiolipin synthase (CMP-forming)</fullName>
            <ecNumber evidence="10">2.7.8.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6117</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="2.7.8.41"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.41" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q364"/>
    <dbReference type="STRING" id="318479.A0A158Q364"/>
    <dbReference type="WBParaSite" id="DME_0000175701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000175701-mRNA-1"/>
        <property type="gene ID" value="DME_0000175701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000175701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25509" checksum="8DA8BD8435D2621C" modified="2016-06-08" version="1">MIKYAIKLHDFDFIIKPLLTKHLENYSEKDMQKFATGKSFEDLKQFEKDEKLCGRIATVPNALCVLRIGMTPVIGYLVISECFIAACAILVAAAGTDILDGFIARNIRGQSSLIGSILDPVADKLFISTLFLTLTYVNLIPILLTIIVLLRDILLISGGLVKRYQMIESPVTFRKFFDPSVSPLRVAPTLISKLNTVLQISVVLTSTVSPILGFVDSAILNYLWFFEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3D4</accession>
    <name>A0A158Q3D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Orfan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6559</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3D4"/>
    <dbReference type="WBParaSite" id="DME_0000219901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000219901-mRNA-1"/>
        <property type="gene ID" value="DME_0000219901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850587at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056675">
        <property type="entry name" value="DUF7773"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24982">
        <property type="entry name" value="DUF7773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7773" evidence="2">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000219901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20745" checksum="0DCB397E25160A8D" modified="2016-06-08" version="1">MKYSFYFPNKNFIYYSNIFILLANNACKGLLPTKPLKCFDSSTQFVCYSEFYSVLIDGKYINKFERFCVYANDCEYRGIANNCVTINQLDSVVQKSFYENIAKKYGFQQSDLILSRLMFKIGNLSIVEKIYFMLSFSCSSNIVIVAYLLFSIFIPLDYFTSILKIFGNILYIHSYLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3R1</accession>
    <name>A0A158Q3R1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SDP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7137</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3R1"/>
    <dbReference type="WBParaSite" id="DME_0000297801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000297801-mRNA-1"/>
        <property type="gene ID" value="DME_0000297801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852895at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000297801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="55174" checksum="71330A4CE1D05026" modified="2016-06-08" version="1">MLHGETECQKNSESNADLDELARLNEKLLERSRARRTDYKLVNPEIVKTSPDPIPQNIKENIREILESRTSNDYSINSTIPQNDRSGYVTMLQDASSATWQFSTHSFSPRSVVSINGGSKADDGLLQDDKPRGIMKRKDLETKTQMMYADEPKHVISTSHMEQKQNVVPSKPKVTETVHKFEEHKRTEEIERRVQRKERKEKKRRGHRSYHHSGHQNGSLTRHNYSPSHESYMRTITTRRERDGQYHDNGRHHMMNGGLDYERYGSLSDSLRRGDMKYDPNGEIREVYHTSHDGRVHKSYSTRDVFDTGNYDDYRSSPSQYRRSSHQQNGPLVEFPPTLPRADIERDAPMPPPHRGRSTSNDFYKPISKSRSYADWDEGRGFEHAIRRREDDISRLENEFRDSLLMPMPRTGGNMYERDHRTEQIPGGYETYDRHVKANSGRRLNRDGNPTQFSEASQEYSFKREVESDRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4I5</accession>
    <name>A0A158Q4I5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS551</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A158Q4I5"/>
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        <property type="protein sequence ID" value="DME_0000493001-mRNA-1"/>
        <property type="gene ID" value="DME_0000493001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000493001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18717" checksum="BBF4171FEE173464" modified="2016-06-08" version="1">MSSGESSSESETFEVRPLPPDYIGSLSSSESDDDFDRNSSTSEPNRSQPFTNCSHLHMVCQVPSGAFDSFGPCAVCSRSAENWICITCYIINCSNNVLNHAFTHFCHTNHPLALDLRNIRVWCFYCREFIKNSAVLTMKRIANLSRYGEDLSQELIDDESTINASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4S7</accession>
    <name>A0A158Q4S7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS673</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4S7"/>
    <dbReference type="STRING" id="318479.A0A158Q4S7"/>
    <dbReference type="WBParaSite" id="DME_0000562801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000562801-mRNA-1"/>
        <property type="gene ID" value="DME_0000562801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="2132"/>
            <end position="2263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000562801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2366" mass="276500" checksum="B8D7A4CDBC90D871" modified="2016-06-08" version="1">MSATYRATSPAFGNGLPPPPAVVATTAAAASFFQNQPQQQQSGGYHASPHQMLPENILEEKARKWKQLQSKRYAEKRKFGFVDSQKEDMPPEHVRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDCKVLYHITGAITFVNEIPRVIEPVYMAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEPIQMELDPEEDRTVIEWFYDHKPLASTRFVNGTTYRRWAFSIPMMATLYRLANQLLTDLVDDNYFYLFDLKSFFTAKALNVAIPGGPKFEPLIKDVNAFDEDWNEFNDINKVIIRAPIRTEYRIAFPFMYNNLINALPVQVSWYHTPSVVFIKTEDPDLPAFYFDPLINPMTLRNAEKNIDPLPEDDDFLLPEEVVPNFSEVPLYTENTGNGIALMWAPRPFNMRSGRTRRAIDVPLVKTWYREHCPSGMPVKVRVSYQKLLKVFVLNALRHRPPKPQKRRYLFRSFKSTKFFQSTTLDWVEAGLQVLRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLNNVDAYQLADGLQYIFSHVGQLTGMYRYKYKLMRQVRMCKDLKHLIYYRFNTGPVGKGPGCGVWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARVILQHLSEAWRCWKANIPWKVPGLPTPVENMILRYVKAKADWWTNSAHYNRERVRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISAEEAVAIYTATVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKNRLNQSQREELALIEQAYDNPHEALSRIKRHMLTQRAFKEVGIEFMDLYSHLVPVYDIEPLEKVTDAYLDQYLWYEADKRRLFPSWIKPGDTEPPPLLTYKWCQGINNLQDVWDTNEGECNVMLESRLEKVYEKMDLTLLNRLLRLIVDHNIADYMTAKNNVLINYKDMNHTNSFGIIRGLQFASFIVQYYGLVLDLLILGLRRASEIAGPPQCPNEFLTYQDIATEISHPVRLYCRYIDKIWIFFRFSADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRCVTTVEWENSFVSVYSKDNPNLLFDMCGFECRILPKCRMATEELTHRDGVWNLQNEVTKERTAHCFLKVDEESLLKFHNRIRQILMSSGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPARFPPVVFYTPKEIGGLGMLSMGHVLIPQSDLRWMKQTESGGVTHFRSGMTHDEDQLIPNLYRYIQPWEAEFIDSQRVWAEYALKRQEANAQNRRLTLEDLDDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTEFKTYQILKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFRGTYFPTWEGLFWERASGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELDALEIQTVQKETIHPRKSYKMNSSCADILLFAQYKWHVSRPSLLADSKDVMDNTTTQKYWLDIQLRWGDYDSHDVERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLYSAYGNWFPGMKPLIRQAMAKIIKANPAFYVLRERIRKGLQLYSSEPTEPYLTSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLSQLAKWKTAEEVAALIRSLPVEEQPRQIIVTRKAMLDPLEVHLLDFPNIVIKGSELMLPFQAIMKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRVILIMRGMHINPDKTKVILKPDKTTITEPHHIWPSLADEDWIKVELALKDMILADYGKKNNVNVASLTQSEVRDIILGMEISAPSAQRQQIADIEKQTKEQSQVTATTTRTINKHGDEIISATTSNYESQTFSSRTEWRVRAISATNLHLRTQHIYVNSDDVKDTGFTYILPKNVLKKFIIISDLRTQIAGYLYGVSPPDNPQVKEIRCIALPPQWGTHQMVHLPNQLPTHEFIKDLEPLGWMHTQPNELPQLSPQDVTAHAKTLMENESWDGEKTIIITCSFTPGSVSLTAYKLTPSGFEWARTNTDKQSNNPKGYLPSHYEKVQMLLSDRFLGYFMVPSSGIWNYNFMGVRHEANMRYDLMLSNPKEFYHEDHRPLHFQNFKGFDDPLGIATADREDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5G8</accession>
    <name>A0A158Q5G8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9958</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5G8"/>
    <dbReference type="STRING" id="318479.A0A158Q5G8"/>
    <dbReference type="WBParaSite" id="DME_0000732201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000732201-mRNA-1"/>
        <property type="gene ID" value="DME_0000732201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000607">
        <property type="entry name" value="Nuclear receptor-binding protein 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000732201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58406" checksum="C44E89CD0E6EE525" modified="2016-06-08" version="1">MISGIGTDSATTAVTTATTTLKSNATDAAAATVAALVDRSSRDRNDANSDSEGEGAAEVESRNLHVKGFQILEESPCKRWSKRREEVKQREVSGIDFAYLAMDNETGNEVVWNEVQFSERKNFREQEENVNVIFDKLTHLRHPNLVKFHKYWTDAKSEKPRIIFITEYVSSGSLARFLHRTRKIDSRITLKVNWPENLGFQVFFTPLNLDCTTVAPPADIYSFGICALEMAVQGGLGSANGGGEATSMISLEIIRKAIETIDDSVQKDFILKCLDSDPAKRPTARELLFHPILFEVHSLKLLSAHRIVEYRLNENLTVDDLRVKNPKKVAAASKLREMTYEEVISFQFDLDKFIDDVNNGIYPITAYVPSMRQKITSSISSSALGGQQSDDHFSEPSERVEPSPSPSGDSHSEYCESRSIVRFDAKMQGSTLTIVLQFNDLMNRQLTTELGKSDTGTNLAAELVQQGLVSEVKEPFFRTNLSNNSFQWVVHIREQVAYLSILSSMNGILANEISYPVFFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5K6</accession>
    <name>A0A158Q5K6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1897</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5K6"/>
    <dbReference type="STRING" id="318479.A0A158Q5K6"/>
    <dbReference type="WBParaSite" id="DME_0000763001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000763001-mRNA-1"/>
        <property type="gene ID" value="DME_0000763001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000763001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49321" checksum="F6CFD3E3EB5594F1" modified="2016-06-08" version="1">MRRSLINLAIHYKIVVVGGGTGGCAVSNRFRKLVSKGQIAIVEPNYEHFNQSAYTLVGGGLMSLVSCRRPMNSVLHPDKHKLDPTKIFRDGSEIKYDLLIIAVGLQLRYDMVEGLDEALKQPHVCSIYKSELVGDVYHKLQKFSKGTAIFTLPSGPIKCSGAGQKICYLADEIFKKVMIHYGIKIKNLISLLILHFVSNGSELQKGVRNNIQLVYNTYLNDIFDVPKYAKALNEVAKEKSIIVHLRRNLKIVDLIKKEAVFEILDTDAKATGETDTQNVSFNFLHVAPPCSSTELLRNTKDITDANGFLDVDPRTLQSNNYGNIFGIGDCLGSPNKKTAAAVYSQMKALSINIPAFLKGKKLTGEYNLYSSCPLIVDFKRVVLAEFTPDGPLETLPFDQGRPLRSAFILKRYILPFLYWNFGVKGNWLGPSAIRKLLRFGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6A0</accession>
    <name>A0A158Q6A0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3210</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000113">
        <property type="protein sequence ID" value="VDN53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6A0"/>
    <dbReference type="WBParaSite" id="DME_0000952401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000952401-mRNA-1"/>
        <property type="gene ID" value="DME_0000952401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000952401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51250" checksum="7CB8934DD26E134D" modified="2016-06-08" version="1">MLSFTMSFIFFGFALILTFGYWKLSLNEINILWAGIISLIISTLYLINIFLSVNYIGSKTADFHSDSPSKIIVIHENIDANDKVTKDEMDFEHSENSICESRTASDSTIPVHKRPIPFNPTIHLNSNHTDVKTVQDQPKDLEKGINRQYWQIENTARIQSEIDSASGEFDGNIDKGCTTSSNEELKQCYFTNISNKQPQQPIIIGQYSPPSLQNRKPSRLKYDLFRSTSRISPSSSPSRFNNRNNREENQKIEQINTNEQKSLQKQRRFTTKASELLNSRKRFSKIGDRNKIDKSSDEESTSGSIGSTNCYEINPKIDNARQSSIIATEKYLDSAHDTNKAPNERYTDRHHQSSPTFIKSNNFAPSDTYGRYVRRMQRYASVDTLNDNNVIADEYIRCPTSLSLESPSCPSYIPPIIVAIDSARESGIVRHYSPRLKSRKRIASGKRGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6E2</accession>
    <name>A0A158Q6E2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10769</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001245">
        <property type="protein sequence ID" value="VDN60796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6E2"/>
    <dbReference type="STRING" id="318479.A0A158Q6E2"/>
    <dbReference type="WBParaSite" id="DME_0000984801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000984801-mRNA-1"/>
        <property type="gene ID" value="DME_0000984801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862:SF0">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="203"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000984801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57758" checksum="2C2E072EC4205140" modified="2016-06-08" version="1">MGETSGGEGYWKNVWECSNVLGSYLNTRNIKLEEKIVIELGAGATGIPGIIALKCSAKKVIFVEHPQNSQALELLEKNCSLNNIPITSFRVVGLDWNDIDGINNLIKDLKHLDYILGSDIFYDPVVFEGLVTAIALFLSAFPQAICIFAFEERDSDWSIEDLLYLKKLHCSLVRTVQTDLHTFRIGFIFSKQIYETTSKMFAGIEGGATQSKLVIIDGDGKTLGEWVTSGINICLDGFERSIEKLVSWIRSVKEEINVTAPLRAVAMGMAGAEDEARNEVIVNFLNENYGDIATSFYLTSDSLMSLKTAFDSGVVLIAGTGSTCRLLKKDGTVHGVGGWGHQIGDGGSGFWISVNTIRKIFDHDDGLVESPHSTDLAKKLLLKHFSLDDKIEVLDLLYSKFDKSNIASFTNTLATEGSSDRLIQSIFYDAGKILGSHVRAISRNCDSDMLLNMPVLLVGSLWNSWELLKIGFIEGIRENKLIKCVTLYKLMNSAAVNAAVLAAKNCNYILPVQQISIVFDTIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6L1</accession>
    <name>A0A158Q6L1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="3">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3839</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000199">
        <property type="protein sequence ID" value="VDN53866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6L1"/>
    <dbReference type="STRING" id="318479.A0A158Q6L1"/>
    <dbReference type="WBParaSite" id="DME_0001036901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001036901-mRNA-1"/>
        <property type="gene ID" value="DME_0001036901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="13">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="12">
        <location>
            <begin position="279"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="14">
        <location>
            <begin position="504"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="12">
        <location>
            <begin position="711"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0001036901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127702" checksum="DBD1959BE63717DF" modified="2016-06-08" version="1">MTWGVAGLAFDDEDIDYYYQLFKSQIGRNPTDVELYDLAQSNSEHSRHTFFKGRLKIDGKFRSETLFDSIKKTQNYSNNNNIIAFTDNSSGIEGFEVSNLVPLNCLTVSKLDIVRSKRHIIYTSETHNFPTAVSPFPGAATGVGGRIRDVHATGRGAHTIAGVAGYSFGNLNLHGYTLPWEDGEKVHIFAKPSEIIIQASNGASDYGNKFGKYIILRFYLMNDASITHSEPIISGFSRSFGQTLEFTDGICRYEYIKPIMFSGGIGCIDEINVYKKNCEAGQLVVKIGGPAYRIGLGGGAASSINIQGVPNRYSELDFGAVQRGDPEMEQKLHRFIRSCIECGRSNPILSIHDQGAGNVLKEIVNDLNGGAIIEASKFELGDPSLSIRELWSAEYQESDAILIDPKKIKIVDEIAKRENCNYSIVGKITGDRIVTLYDYSSDHKSPQEDKMRAPFSISLDHIAIRNPKVYHLHDGATLTHSVLLPSFSIHNALDLVLRLPAVASKRFLTNKVDRSVSGLIAQQQCVGPLQTPLADVAVVALSYWDTVGAAIAIGEQPVKGILSPEYGASMSLAEALTNIDIKCSVNWMWPGKFGKEGLRLVKACDTLCEAMKTLGIAIDGGKDSMSMTVQMQNGSIAKSPETIVISAYAPCTDITHVVTPDLKGNIETRTELLHVEFGGYDNHTLAGTALAQCLGQIGNKSGKIDWENFKAAFIAIQNLIKEEQVLSGHDISDGGLITCAIEMAFAGNRSIILELDMKEWTNKMEMLFAENPGVILEVNSDTYKTFLNLFQSNGVLAKHIGYTGQEKGKAATVIIRINDEQVLNEPLGNLRQIWEETSYQLELLQTDSECAEQQKYYLEEAEEIIFQANFDFSIPMSNFLKSSIRESYKVAIIRAEGSNGDREMAAAFYMAGFIPFDVTTADLTEHGFSLKPFIGIAFVGGFSYGDVLGSAKGWTSVIKFNEKILYEFNGFRNRNDTFSIGVCNGCQLMVSLGWVGSMDRDNDGNIFLEQNDCGRFQCSFNSVLILKSPSIFLKGMENSILGIWTAHGEGKFGFRDKRTLDKLESEKLVPLKYCNALGQPAKIFPENPNGSPRSIAAICSMDGRHLAVMPHPERSFLSWQWPYYCSQWKSDCLTAPWMRLFINAYHWAHDRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUH9</accession>
    <name>A0A3P7PUH9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUH9"/>
    <dbReference type="STRING" id="318479.A0A3P7PUH9"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="77" mass="8474" checksum="0747AD8D488C76D7" modified="2019-02-13" version="1">MIEQFANIFHGNSYEQQYHVATMNNAPLLSNNIPSRSNNTVEQFTADACTVCGDKSTGIHYGAISCEGCKVIFPLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXJ0</accession>
    <name>A0A3P7PXJ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 DOCK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXJ0"/>
    <dbReference type="STRING" id="318479.A0A3P7PXJ0"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="3">
        <location>
            <begin position="589"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="4">
        <location>
            <begin position="1674"/>
            <end position="2121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2186" mass="248479" checksum="ED6462E6E7374349" modified="2019-02-13" version="1">MRIDFCRFSAAVGKPGQAREARAAVRSAISTINPVKSIVMPSQRRITPFVDHQCIADANWLLTQEALFLYSSPYQIVTFNYACFSDAFSSVNKESALELKPLVFESDLEVEEEKTFAKQSASGNIHEGYLLLIPDPGLLDNFKNVKKRYCILKHEIDGNVVLEIQKQGIKTCSPFIIERVVLGTKKGRDVLEVLVFGHGIERRSILLTADVDGDLRLWFMEINKALIMSRPGNSKISIPNSSTISPTDSGSLDSDGNLSGDNASLSSAMKLLLSEPFENKSSLFMQYIPDTTNANGSKIVFRFTVEFVKLNLKVRVSNTENKQIEPFFIRFFIFDARAGRRLSEEFHINPNSDEINALIKGHTKNNGSSVEKRDLKHDINYGIFQQQLADTNINKVVFSVEEPHVDIYLIICIERILSSDSYGEAYMKTVGEFKSTLKLQKMLVQACNKLSEYRMPFAWTARSIYQDMLGCNTRIPDELQLFRSDNNKFNESDLQKILIDFTRYSSRVVSVKWYFYFRNEKSGKLSIIPGSSITAKMEISSKIIEHQMQINSTSMPSSSWNMASDSSLSACFEAQSFNNFGAEPHTNFINNLYVYPLMLKYDNQKVFNKARNIACSIRFVSFEGQNEKISEVIYNRFVFPVSFVRVAHTAIHYHEQCPLFSDEIKIRLPVTLQPTDHLLFTFTHVSVGGSLSLKSANETIESAIGYAWLPLVKGDRLVIESDEQEVALPVASELPKDYISYQSLGLGKGHSGPDIRWVDGGKPLFRIRLRLISSVFTSEPNLQMFFQSCQRLQRAGVIPDAVDKIFYRAARNESLSSSAPPSIDDNEDKIEKCCQHITRKAELLRFNIGVLKIFFHALLDIEINRLIPYLPLILNRLLLLLCVSVSENMAHGCLRVRYSEVPWLKLRPILNITFAFAIWRQFFISEMSYRIISAFFFSTLVGIIDRATKTGKEIFLRSFIRNTFQPISVKTRTSPEDETTHSSVGKYLPSWIIKFSDDLDILAPILRHLWFFLDIFSKSMAQKVLDLNLHKLPRRSRFSPEFLYRSKTMVEELFSLIISKHRDIPQECRIANTSIAYFLRVLRDYKLELLRILAGHEHWLPLSLPVLLDANVNYSDEFFLSELYCRHHFLVGLLLQELRASLRESREYRRRVIEVVTKLLAKHARDKRKLIGMLYLHSIDGSNVLKAKSELRKLFQIISGSSAQGKIAILYLPLLHLAMENLNELESVSQQCDPVESSVVNAVSRIGERASSLTVDFRNSIRSDFESLFSEPARSMHQRNHSYHPSSQPISCETHIAGLAEKLDKNEKMQKNAKKIEGKLYKVINESYIERETSDILLCVLFILHNLPRKILPLLWSHFESKGLLSDFINLLEVILATFRYRGKTDFLKFANNKLYFSHAGISPGSASISRCVIMDQASVGSSSSEAQIIGSPSIHITEPGEATLYSSIQESNLIQEIALTVLDIVRDLAEYISTRLNFLMDPGIEKTISKLLSIQLSVLGDHWTEAVRLTSLSVLADFINLFRSQLFENGSINDLSALIEGLLLQLNSRFSTIQSSSTALLYLVLKNGYDCASLILARQTVANMVPTDIRNSAMKNISLIERLGPPGSQTSVALSRLLGRKVPLANSIRFENGLALLESYVTTEMKPKIFERAVQELIYQLKGILSATGALTDSYRGSAALRSAWFESLANTHIRERFYAEAAACQAHVVAIIAKELYFNGNVMATWHIVFAGIIDVDWKLFEAISETITKDEKVFDKHSAIIQQAGFCLVSFDNYTSTIEKVVRSLFFAERYEAIGPIYRLAIPVFEQQNDFESLVKVYTELQKAYSLAEQMKITGKRHLGTYFKIFFYGQNHFKEDHNTEWIYREPGLISLAEAYERMKEMYYFALGHERIQIVAEGELNKEDLKDDTAYIQLTHVEPFKDGVNRSDFDLHTNIQKFFYEMSVIDELYPEAPEVARQGLKLDLPFPNVRRRARVINRAEIVLSPLELARDKLLFKAKQIRRILDSTKFVGTTKKGISENLDIKGLQLLLQGAIQPTVNIGPLAYAEAFTTPSQIERYGDDGIKSLANAFICLMNECGKALDANEAAIGVDQVEYQNMLKNAFAAMVERLQVFFGKNVKSSSLTENIVRNSVHIFDSIGDLILNASKKQLFSQQDNSNIWAVLRMKFHNISLMFLMNRVFRLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q016</accession>
    <name>A0A3P7Q016_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS10693</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="16"/>
    <dbReference type="EMBL" id="UYYG01001236">
        <property type="protein sequence ID" value="VDN60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q016"/>
    <dbReference type="STRING" id="318479.A0A3P7Q016"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN60720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="353" mass="41173" checksum="CFD56B36237093B0" modified="2019-02-13" version="1">MGILALWQIVKHGVSDKLITLIRAFYWHIIAQFVNTFPSCLLVVLFFIMGSTLGFYRATIFYSNWISIISLLNIVSLLITFILYVRRQTSDFFNSIDFYYGTELTPTILDIDIKHFVTYRISFTLWAIYIISAYHYSKSIRGQISLELIACAILQLIYIARTLWFEHFHYSQLDAQVDKAGFCRIWRGMVLLPTLYVTPISLLARNQSVLPKPLSVLLFLMGLTAIYVNTDINQQRYNFRIGNGNVKIWGKDPFFIAAKFRRENGDFGTNLLLGSGWWGLSRHPNYLAEWLSFMFWSLLQGSTTIIPYSPLIYLAIFLYLRTVHDEIRCLGKYGNYWLQHSNRVNFMLIPSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0G7</accession>
    <name>A0A3P7Q0G7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001261">
        <property type="protein sequence ID" value="VDN60890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0G7"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="32" mass="4097" checksum="C6B2325466FCA2AD" modified="2019-02-13" version="1">MSYINRSTFSPRNHISSVYEFFYRRSWVEYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q8X1</accession>
    <name>A0A3P7Q8X1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q8X1"/>
    <dbReference type="OrthoDB" id="5864052at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26840" checksum="22622768B77B0DD6" modified="2019-02-13" version="1">MSGLEIERLQYETGLSVIGDYRTSEHNPKWKCTDSVAAEIGAQLALNKIDYTNRILSELSDLQKLEATCRLYEGKISTLNECPMNDQVHPSAIIVLLPLICHDRYKILANMRECSSTMEEAIGEKCQKYCASRLLKGFDATSPYSCEFASCTANCINAQVRECDNSREVSNLYNELAGWQLLMGMENSFNGDSELTYRYLASADFPKYCHDMITRTLIASSGQSTFEQKKTGNTENESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SCL2</accession>
    <name>A0A3P7SCL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SCL2"/>
    <dbReference type="OrthoDB" id="5804099at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="385" mass="43178" checksum="2825219A3A906E0F" modified="2019-02-13" version="1">MYRSFLVSVDDLIQGALNLVRPIIDTSKPLDDVAILPKRILSNQNLIRENEILGASRRTILGDIPICKDNARICQFLSCSAKKFKNDESLANLKLIAQILADKKLRKVISSDPSAIQAACHEYGLSQGQCKLFAKAFQLIERFISTIDPSEEKFDEKPISNSESSLNHQQLESMDDNMDDAPPIPIPSGRKTPENDDVPILGSRTWSSHPAPVGVVENQIRLPPPSPLSLPTFPPLIFTFPSFTFLPTLPTSSPINLPNPILANPQDSFKNLFLNVFLPPKAIHPLSRKRRHIDFNRRKHQMNNAKNSYLENPGKNGIAKNVYGYKNRWKRSDYYDDIDDGTTKAINHKLVKLGILGAQTDYPDYSGTDAEENLVDGFVECIQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SI97</accession>
    <name>A0A3P7SI97_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SI97"/>
    <dbReference type="OrthoDB" id="5844891at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="92" mass="10996" checksum="0CFB8BFCA4540F04" modified="2019-02-13" version="1">MNLNEYRGHVYYVFGLVCLVSWFIFNLWILRDYFFPWIFPPIYTQTGLKMKKLEATKMQLIRKDRLNNAFTIPAAIILPYLSPTCRGNKQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0H0</accession>
    <name>A0A0N4U0H0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4410</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0H0"/>
    <dbReference type="STRING" id="318479.A0A0N4U0H0"/>
    <dbReference type="WBParaSite" id="DME_0000005001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000005001-mRNA-1"/>
        <property type="gene ID" value="DME_0000005001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000005001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42080" checksum="478453BE0CB27E16" modified="2015-12-09" version="1">MATTWADIKRLAADLQRVQLLEGTKKLSEKNCVEVVSILIGSKAVDLVFTVDGQHYITKKHLLTEIKNECLGNGGRISLSALAQVLNVNYDVIESVGSFHRLSHSRLLENALFFFFRCYIDHLCSEINEQLTEVGALSISYLVKNWNLPFDLLNDHIFAKVGCKINATRDFDILYTQNYLSAQKNLIRAVVNALTKVTPVSKMIDSIGISPSLFWTLFDELLSCNEIPGKTIGSRNSSHIFYVPNIHTKLSRLFVTKTFAEHQLLELSILKKLSITDPLSFLKELLPESDFKSLIFLPSKLLKEIMENVENEVQLVDRTTIEKSKKGQKQASKTEDVVGDFFYIDLFIILIFYYCFIFLFFFLLVDHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U118</accession>
    <name>A0A0N4U118_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4631</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U118"/>
    <dbReference type="STRING" id="318479.A0A0N4U118"/>
    <dbReference type="WBParaSite" id="DME_0000027101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000027101-mRNA-1"/>
        <property type="gene ID" value="DME_0000027101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2142533at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051594">
        <property type="entry name" value="KRIT1/FRMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283:SF10">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283">
        <property type="entry name" value="KREV INTERACTION TRAPPED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="53"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000027101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="61105" checksum="5ED05A62BD89D6DC" modified="2015-12-09" version="1">MKRPNILCSELSSDLSLKALNDSPVNDSPVGCVLRDIATKQTNQCQKIRDQSLDVTVLLPDRRGFKFPSLVGKNIYAADLLLRMADHLKVDRKLMKECCSLWMVSPFLEVQLKPHHVPFEIREHWSDLLNRFADVDQKEKNCDEPFLYLKRNVYLSVQREIEVFFSNIYLHVRIAEWLSCSADYFWITVVYAIKFQIEDQSEYLTEILYLCAKQEVLEGRYPCDIETSIRLAALQLSIDLGSFDQCKYTACAVSDIVDKFIPVQHVQNVKSMYLFGFPIFGCKGLESDIIDELKIISSKYGNNHSKRKAYLEIVRCFPFYGSAFFHGYVERPPARSLKDIKRMILAMAIPEIEVYIGINYDYITIIDSSSHEILLIQSLSGCTWHYIDGFILHKTIFSHQAIMMEALMNILYNIVLSKNEEIKFIDDDEKECNNTHYYEKLKENKGESLFDELTFFNRKSIKIPAVSIDCDAVPTSFCNLEFKCKAQANGQYSRNSCVRQLDKLCLATFDGTERCIKAEGSLRYVFSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U192</accession>
    <name>A0A0N4U192_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4717</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U192"/>
    <dbReference type="STRING" id="318479.A0A0N4U192"/>
    <dbReference type="WBParaSite" id="DME_0000035701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000035701-mRNA-1"/>
        <property type="gene ID" value="DME_0000035701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000035701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26952" checksum="CFA230A387C4C1E4" modified="2015-12-09" version="1">KFFDVFLSFPLDNGGVLQVERYYSTSLHGVIYKKTPYKIHVFYVGHGELVLMVFDIKTLTSIIIINGHQNKIAAVRFSWDGKKLATASIKGTVIRVFDTFSGVKLFEFVRGFQRSAKVGTLAFSEDSLYLALISDTPTVHVFKLEKNATCGWIDYLSRTALSYLPTQVNEVFAREKSFAVARIPSSRPSTAVAMPLIDGQHYLFVLSSYGDLYCYTVKGQGGELSLLKSYLVCFIQFVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1D6</accession>
    <name>A0A0N4U1D6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein CWC15 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4773</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1D6"/>
    <dbReference type="STRING" id="318479.A0A0N4U1D6"/>
    <dbReference type="WBParaSite" id="DME_0000041301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000041301-mRNA-1"/>
        <property type="gene ID" value="DME_0000041301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000041301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25444" checksum="6A8EFC1442F9C2A4" modified="2015-12-09" version="1">MTTAHRPTFEPARGGSGKNEGDLSKLSQQYSSKDMPSHTKLKYRQKGQSHAEEIRSKDLRRELEEKERLSSRDRRSRDSGWSSSSKKARVEQPIYNTQDEDDPYDDVEENSESDDDDDDTAELMAELARIKKERAVEKAQRDAAAAEERERVRTDNILHGNPLLNMESADFKVKRRWDDDVVFKNCAKGIEERKKEQNFINDAIRSEFHKKFMEKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U237</accession>
    <name>A0A0N4U237_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5072</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U237"/>
    <dbReference type="STRING" id="318479.A0A0N4U237"/>
    <dbReference type="WBParaSite" id="DME_0000071201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000071201-mRNA-1"/>
        <property type="gene ID" value="DME_0000071201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5782901at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF46">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042210" evidence="5">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000071201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15621" checksum="6E97C395CE844AC3" modified="2015-12-09" version="1">MVCTMVYSFVLITIYLVNVKCRTECFQVVGALVCPDEPERAGRVKIDLRDEDSLPFEIDDQMGRTWSTKNGSFVLSGCGADVGPFNAPDPYIVIEHRCTSKLPHLRNFTFRKTQFALLKIFLPRILKIGKVFLDDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U455</accession>
    <name>A0A0N4U455_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5909</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U455"/>
    <dbReference type="WBParaSite" id="DME_0000154901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000154901-mRNA-1"/>
        <property type="gene ID" value="DME_0000154901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796062at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039127" evidence="1">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7808" evidence="2">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000154901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20801" checksum="EF5B637F84925809" modified="2015-12-09" version="1">MKEAIFFVAIWFSLVGYCYSTPKKPYYWTTRKFICNTIHGHDVSRCALHMSDRKVELNPGCHEELKEVAENNQTRIYCRIMCEESNDITILNKIPTWNHVCNIFYNYQLERHREDWYLWRSGDCLNTTITFEIRCGFARDPRIFYRENTKLFEYDDAVDDRNNKIKKIKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4N4</accession>
    <name>A0A0N4U4N4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6113</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4N4"/>
    <dbReference type="STRING" id="318479.A0A0N4U4N4"/>
    <dbReference type="WBParaSite" id="DME_0000175301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000175301-mRNA-1"/>
        <property type="gene ID" value="DME_0000175301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6415022at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056519">
        <property type="entry name" value="KANSL3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23154">
        <property type="entry name" value="KANSL3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANSL3 helical" evidence="2">
        <location>
            <begin position="780"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000175301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1232" mass="139324" checksum="F3646569D3E835B5" modified="2015-12-09" version="1">MVHSTAYNRIARRVENRLYELICFLIGPRKTSVVVCLSDLTKKLISLPVVEFSLPPNFINRRKKRIPRRISVSSTAQPKKKDTLSDNLQTKLAPVSPVKQASLVSACVESVTSKKLEMIDSVKSAMVDSNNENGDSLLSSKRPRRGKKTSIYSTKTRSKKESISVVSKSDDISSIIKKKRSARLWEKLEHLIHISNDLSEKSEKVEMHPPLIQETSSNEVDKSDDASIDDKRITAVVKDRSNCSWKDEEEFSEDIAVEIKCALDELISQISEQTEVNAKPCDLITEPLRLPEERRIVPPLRIRLPNKRQMRARKPARSKEYSPPGPSSRQKYLNSGGTVGVNQKQRFGTSLKECDETAFGDSNSQILSSSCSSEHNNSPNQELKTLFMTLPDYLGLSSWIHLTTLILSFVFLQLGTSSLAKVDCEESREKSFNKPGFETSLQNISSNKSDNSKLGCENSLQNIFSNDDIFTTESEDASIDLRMDFTSPVQQYEANAAVDFKLVDEGKETSTGRHLRPKSVTYKELFPELFSSRRRKASNSNQLPPKKVRENERKSEKCVEETVEHGTPQTSSTAEAHIGSTMIEILKDNALEEQDSLNLPVVSNHASSPFEHSQKMYRRDGSALERKRRMYNVNADTNNSPDDDDDNNIGQRRQHSKESHYEMFFDPLPPILLDSKDFCKEFEEMHAKASMNVGNVDFPKNVDQKLRTQCLQPVPYFKRIAQRRKLNPFAIGLKSRSSDNDSSIFYREILLRGEDLRKQNDAEIVVDGLLPQGDDDDVGTVNPALEIARSICRVIPRPTNTDDDGQSVELTVDDISNLIETESAERKELLQDLIKIIMSQYTSEIVSENVTGGASIQYDTMMKNCYRLRDRALLFTQERRDNVIWAHKSLIENLPINILATYINMLRFCKTMDRHLIDLILKKDSYDKIKSLIQPIRDFILSKVYDPQTIAISKTLSVSVTLKRRVDSICLIAVGPYINAGDYHPKIKSHDYLFRILLPNIVHYVEHVRLCLPISSEFSACEAADYAITLVCRKVNEVHKRFPSKKIVLVGWGLSGLINHQVVQCTSDISAIVNFAFPMKTVEGMRGDVDDDILLTYCPTLFIVGEKSTDCNIYELQRMASRMIAPAGVMLVGSANNNLQVSSLRLSTERFTQRTVQRALLDDIVDFFEKYCLGPLSNLNRQKPVALAETNDADMSLLKFTSSLFGQHCTSRKDSGARAARDRLKIDWQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5L2</accession>
    <name>A0A0N4U5L2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cadherin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6503</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5L2"/>
    <dbReference type="STRING" id="318479.A0A0N4U5L2"/>
    <dbReference type="WBParaSite" id="DME_0000214301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000214301-mRNA-1"/>
        <property type="gene ID" value="DME_0000214301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6079678at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000104">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="37"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="143"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="258"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="363"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="505"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="596"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="767"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="809"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="933"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000214301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149588" checksum="54AD9A6D1708A1E0" modified="2016-06-08" version="2">MKKYSEKRRKKRGISARTQLIRIDVIDVDEPPTFENGPKPYMAVVPYEQPIGMYIYKFVARDEAGDGDKDVEYRLINTEPNGMFTIDSTTGVVRTAVKNYKPGKTYRAFVQARDKTPSDPNASQDSEVAVLEVYAGDLPPQFVKHYYSVEIPEDIAVDSSIIDVRANRFKPINENRSKGDLVYALYSLTGGNERKSSKFFAIDHFTGVVALKQAVDYDDNSQPKLHKLLVVAQEDGKESSVPLDISIKDVNDNLPTFTQPIYIATTKEDIKPGKTILTVHADDKDSNENAKIVYSLDNKNFTINERGEIAAAVRLDADQNRERFFIYRFHVIAIDGGQPNLSSKAIVHIRTENTNDEAPDFIPSRMYSAFVAEDAQGGTPIVQIQAIDPDRDQVSYAFLMANGVYSTTTELFEIDKDTGLIKLKQNVKPEDLLDGISPYNLTVIATDDGSCCTDESASVVHSQTAFVTIGIADVNNNKPEFRDCETYSRIAKINEGDYKTDPPIIVKVVATDEDSPPNGEIVYSLYYSQSESRKPFIINSETGELRPSPFVRFDREQRAQEEVTVKATDKGERPLIGFCQFTVQIVDINDNAPQFDRASYETSISRSVSVGYSVITIFADDADAPHNARITYSLSEDNSAESEHKKDVEYFRILNENSGEITLVNQIPPLKDRFIFNVIATDNGIPFAQNSTVQVIVNVHEKQQSAPQWQSSPDCRTAITVDEDMPVNSILMANGANRGTNNELHFREFLEKVNGRDWVVVRNMVGLDYEQQQNYTLTLTAMDMRSMVTSDKHFHIIIRDKNDAVPRFTVDRFTGTIEEEQTPSEFMSKYGGRPITTVKAEDADSPGPQSEVRYRIIGDGIGSAARLFRIDELSGGIYPLEMFDREKNDSFIFDVEARDSMDSSLPGATGPNRDIVKVQIFVADINDNAPYFDEKRYEGRVSENVDVNQDIITIKAHDLDRLSNLKYDIYAVHGGRIPFGVRTDSGAVFVKEPLDYEEENVYHMKLLVTDGKHNATTDLFVYIDDVNDNAPQFEKSLYEITVLEEDQDVPKTLFIVKAYDADKDAKSKEIVYRLEGQGVGEFFRVNERTGRIEMIRPLDRDPPAGVPVWNFIVQAIDDNGRGLIGYADVQVNLRDINDNAPIFPSNLVGSIDENREPGNDGVYVMTATAVDYDDPRTDNVVLEYSIGINKEIDGQPVFRIVPSNGKIYAMRRFDRELPSEREFVIEVRATDKGNPPLEGSGNVTIQVKDVNDNQPFFEKSFYWSSVPETALVGSPIMSVSALDKDNEAKDNVFSYELMEEDKYFYMTTEADSSSSSVGVLRVKTVSSFGVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5X3</accession>
    <name>A0A0N4U5X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5X3"/>
    <dbReference type="WBParaSite" id="DME_0000228001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000228001-mRNA-1"/>
        <property type="gene ID" value="DME_0000228001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000228001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13821" checksum="50839D25E581107D" modified="2015-12-09" version="1">MIMGTLRTIDNVDEYENRSWEDFISYGSFREIKEDSGVKGSADNIISGFQKMLYWLHKILSKMAQMISAAKDYARRALSDTVITREGLKCNGIWLKNTARANGLREKKKSVCGRSLKYSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5Z1</accession>
    <name>A0A0N4U5Z1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6663</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5Z1"/>
    <dbReference type="WBParaSite" id="DME_0000230301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000230301-mRNA-1"/>
        <property type="gene ID" value="DME_0000230301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6497308at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000230301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37233" checksum="0BAD21C5ACBB3F39" modified="2015-12-09" version="1">MQQQQQQQQQQQQQQQQQQSCNGQSSELITRRESSIGSNLGANGGVGSSGTNQEHRDEPNSSNEDYSTEKIETTNLGVEVSVVGSPQVFGHHGTTNSPTSESDDERIIERCDLLNQSTTDGLCLPTSDSRPPKKRLIQMTDLPRIRMLHHHNQASAFVEPLKMSSIPAGEHFQQAMNQWDWIQIDNLKIPIVFRGNDRYAAVHIVQLKLLSKFPPNIPTEITNRFTMISHKMLPIEAWIFNIINAVLTKFDLGCQLFTTNDEIVRLADVERFYWSIKALNMNRMIEIYNNELRSTNSTHLMAAITQIKNHVESDLQVIFSTSASEYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U607</accession>
    <name>A0A0N4U607_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFAP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6682</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U607"/>
    <dbReference type="STRING" id="318479.A0A0N4U607"/>
    <dbReference type="WBParaSite" id="DME_0000232201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000232201-mRNA-1"/>
        <property type="gene ID" value="DME_0000232201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="154"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000232201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="48414" checksum="A1A8980F34109634" modified="2015-12-09" version="1">MSEFIPKFERYLYDRVLGPKALPTSGAIAVRNEKGELTMKKVKVSRYVAGKMSSRVPEEPEVVRRRGEIVDDAESENEEEQEMRKIRARMRRMQHEIAKCKTIVYQIEQEGENERRRALLREKALIREQEEAIKQEEILEEEESEEESSEEESDESEEDIMPRMKPVFIEKTKRLTKIEEDKEKERARKLLAEENEKKERRKKETLKLVEEVLRHEIEMEKRKKDNNIDLSAVLTDDENEEIAYESWKLREMKRLKRNRDERDALTREKSELDRIHAMTEDERKQYLRANPKFITNMQKKGKYKFLQKYFHRGAFFLDIEEDVYKRDFAEPTLDDQFDKSVLPKVMQVKNFGKASRSKWTHLTAEDTTDHQGSWAATTALSSKFLTKHAGGMKNNFERPAAKKRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U629</accession>
    <name>A0A0N4U629_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase A(2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6709</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U629"/>
    <dbReference type="WBParaSite" id="DME_0000234901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000234901-mRNA-1"/>
        <property type="gene ID" value="DME_0000234901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830494at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000234901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15164" checksum="AC635F08DBB538E7" modified="2015-12-09" version="1">LKKYSFSVVFSVIYRRILGFAGNLNWQCGSETLSKTISQAIVERDFSINNCCIDHDNCYDKQLGREHCDDILCACIDNATKPSDICNRENSPIFCKLVRLLGEEPYRQSAKKSILLKTSKSPQLCYLMIKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U653</accession>
    <name>A0A0N4U653_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6739</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U653"/>
    <dbReference type="STRING" id="318479.A0A0N4U653"/>
    <dbReference type="WBParaSite" id="DME_0000237901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000237901-mRNA-1"/>
        <property type="gene ID" value="DME_0000237901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000237901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23778" checksum="9FC43A0447921EB4" modified="2015-12-09" version="1">MQRNSANSIGDQHAYAGTAGWQNNYNCSWQRAPSHPISGMPDLSIFTENELRKFILLLHQMQYKPRNPRLYKTALCRYWLVGIPCRFGNACWFAHGPHEVQAPNLVFPRNLVEHLTMFINQQPVVNEIPPINPQNRVAQFNANFNGTHQNNSNSDLNGNFSGSALWNLNNINSNQANSPNVNQYHPFLPQNSQFSCLTGQRIYPHQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U695</accession>
    <name>A0A0N4U695_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thioredoxin-like protein 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DIM1 protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Spliceosomal U5 snRNP-specific 15 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Thioredoxin-like U5 snRNP protein U5-15kD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6787</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U695"/>
    <dbReference type="STRING" id="318479.A0A0N4U695"/>
    <dbReference type="WBParaSite" id="DME_0000242701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000242701-mRNA-1"/>
        <property type="gene ID" value="DME_0000242701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000242701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29898" checksum="A17D0E1102BC3FEB" modified="2015-12-09" version="1">MSYMLPHLSNGWQVDQAILAEEDRVVLIRFGHDWDPSCMRMDETLYKIANKVKNFAVIYLVDTTEVPDFNKMYELYDPCTVMFFFRNKHIMVDLGTGNNNKINWPITDGQELIDILETVYRGARKGRGLVIMADRLTQLQDLVNDLANLMCNSIGVLQLVAPPCDFNTTSKQLENDENCNIFAMNIAHTAKDIEILIDSLPIDEPSTNNAEAEAEFARIDEQRNRAARELESSVAEGEELISQIQQRLSEIARIQIESRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6A3</accession>
    <name>A0A0N4U6A3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6799</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6A3"/>
    <dbReference type="STRING" id="318479.A0A0N4U6A3"/>
    <dbReference type="WBParaSite" id="DME_0000243901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243901-mRNA-1"/>
        <property type="gene ID" value="DME_0000243901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5840512at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38728" checksum="0FDDAB78A992A09D" modified="2015-12-09" version="1">MNEKQHRKAASFSPSTYAGRSRKLPVTHEAFFKKHFRFTAGKRIKYEKKEILDVLKNIKKLLIEEETLLTVNAPCIIVGDIHGQYDDLHRIFITTGRNGRSGATMNRFLFLGDYVDRGPQSLECICCLFAYKLAFPKMFNLLRGNHEIALVNQIYGFYDELKNRFTESDALNLWDAFNDVFDYLPLAAIIKGKILCMHGGLSPNLKSLDDIRKIKRPIRNITENPLVCDLLWADPMIGLNGFAANNIRGVSVFFGENVVLRLCNALKIDMIVRAHQTMTNGFGFFCKRKLVTIFSAPKYDVEKNNKGAIMKVSKHLKIGFILLHHVKPPKKGRKCLAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6E9</accession>
    <name>A0A0N4U6E9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FBO_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6851</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6E9"/>
    <dbReference type="STRING" id="318479.A0A0N4U6E9"/>
    <dbReference type="WBParaSite" id="DME_0000249101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000249101-mRNA-1"/>
        <property type="gene ID" value="DME_0000249101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF29">
        <property type="entry name" value="F-BOX ONLY PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="2">
        <location>
            <begin position="198"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000249101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46796" checksum="9F2055D1816F63AD" modified="2015-12-09" version="1">MLICFRENWKFELDKNRKDGVKIVLQTSNRILTEEEKYEKASTLFLEGVELEQRGEMCEAVHRYTNAIRLVPDIEFKVFRNATKKTSPKKEIVDHQIDSNLNLRDFVIDFNMKDALYQRVMQREMLIMAAAESNDCHISKLPIELLMKIVKHSVGIGLDSFFSRNISVIFNRDNILWHGICLRIFDAKRVELIEGNFANWRHMFISCPHLYFHGVYIGKCTYFRPGEASFQDNFYRPWHIITYYRFMRFFADGVVIMVTSSDPPVQIVSALKSKSTRLNGVLFGRYWSTTQGRIAAEFHRKSNGSQQKLFQKKRFIGREFFSHEIIDQKFYLELRFGSGRKRSAHCTLHWDKYDCTFTYLDGNVSTNSFNVNDRQAFPSFSFSRVKSFAIPEMRDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6U7</accession>
    <name>A0A0N4U6U7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CUT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7034</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6U7"/>
    <dbReference type="STRING" id="318479.A0A0N4U6U7"/>
    <dbReference type="WBParaSite" id="DME_0000267401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000267401-mRNA-1"/>
        <property type="gene ID" value="DME_0000267401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068888at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="9">
        <location>
            <begin position="233"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000267401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35836" checksum="8015868DE412FD2E" modified="2015-12-09" version="1">MEGLETGQMTTSGSDPLLSAALSNCSPTGPHNDDFRNHLPESNYLTLNGGRTSPHNGSNSTNNAIFSQYTTLTPLQPLPPISTVTNSSEKFVRSNSPTPESRTSSASSNLFFQQNATNSLANSLNFGSFAYNVNIKYEYDMKNDQESDDVQASDSTSTQTTTDYVPPVTLHQQLQQLSVPFSQTQTTYAPSYSTVMELRPSKQLKLCFGTPNSFNNFNSTSDIIESGSIDDNDESGSSPLRERSAPPTGSPDSGSDMDELNTKDLAQRISAELKRSQGTLSDLLRNPKPWSKLKSGRETFRRMAKWLQEPEFQRMSALRLAGISHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7C9</accession>
    <name>A0A0N4U7C9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS117</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7C9"/>
    <dbReference type="STRING" id="318479.A0A0N4U7C9"/>
    <dbReference type="WBParaSite" id="DME_0000288801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000288801-mRNA-1"/>
        <property type="gene ID" value="DME_0000288801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846296at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000288801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45455" checksum="76BD14F2031083E2" modified="2015-12-09" version="1">MDDVKNKSLLISSSKYDSEFEDFTIQTDKILLEDKSTDSFEHCTREIQTDKILMKSTISVNKIDEDLVNSIINIINDNNNSSNGIFKKFDSFYITNQILISLIKQIKLQGYSLPIIGIETGANSHLAILYGKEYHDSWCFHTGKVMHIHRSNMYHIPCPGCPLAVRFGPQAVLAIGTTTGKIILALNGEILSESEISPFAISSLQWLTLENFIVGTLDGKIIVYTMKSTQIVERKRTSLSISDLPRKLRKSDSDMRSVGITSVAVYDDLFVGGETGNIWRITLSDFSKTNFGSQIGCIERILCTTSKLITLTSLAKAAVWSYSGDILIIIDSRINDINLINSNIMVFDTCDHNEIIFYSLDDNKEINRKQLSHSLFSISDNKYLIYIDNDMELHFYDIIFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7K6</accession>
    <name>A0A0N4U7K6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF4515 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS201</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7K6"/>
    <dbReference type="WBParaSite" id="DME_0000297201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000297201-mRNA-1"/>
        <property type="gene ID" value="DME_0000297201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000297201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="659" mass="77049" checksum="AD9503BF38A3B515" modified="2015-12-09" version="1">MEEIHKQYVCNVADMDLQLKLQRIYLEQLKAENQKRKGQKKLVGDQKSCNGTNPDVLESNINNIITQVKAHTEKAEKLQKALHVGCARLQKAQSQLKDSEEKIRLFLDKFKTKAAALDTFKNPYIDLGSIDKAQEVYENFKNVFFQQLNNALPEYLHNEYLSQINSRINKLSEENSKLTNLEEELRKAVDKYEECEGEYYKQKSYHDTLTEKVQIMCEEYQKCCNRLSECKERISQLQLTFTDGQCSTKNYNETLTTISAQLEEMKKENEKLVEKIDRLETEQKIAECYHEKNRSLAKHFNDERSNLLKDFQEFAETIVRDYKAELEKKRYRKIDLTAKVENLRHVKARKIEYETSKKLLDERNRVLNGLKNKLIDLKEATAMKAKHLEEIKSERKRRAEEFEKHLNFLNIIVGKLKKEKGKLETILILQKQKAEENRLKLNKSKEMKISLLDGSIDVQKKLLHSQTSIANEMNIKHSSNEVIECGEKEKKSRNEYWHQAFPTNEHEFIKSELNQVKKTRGKTGVRKEQSEKPSHDLDLGKLQDFGYEKSKSPRPSRRGRKRCKNNKANSVKHPVLFESLLSSFDAEQAITSTPLSSHNSSIQPIKNESSLYKSQRSIFINGKLSKSNKRKPTNFAEVRANKEKYKRNIFDFASESDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7P8</accession>
    <name>A0A0N4U7P8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chorismate--pyruvate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7178</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7P8"/>
    <dbReference type="WBParaSite" id="DME_0000301901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000301901-mRNA-1"/>
        <property type="gene ID" value="DME_0000301901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000301901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="4141" checksum="ED23CF466E902620" modified="2015-12-09" version="1">MQNESLIRIRQIRYAAFELVEPKCRIYFAHFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U860</accession>
    <name>A0A0N4U860_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7368</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U860"/>
    <dbReference type="WBParaSite" id="DME_0000320901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000320901-mRNA-1"/>
        <property type="gene ID" value="DME_0000320901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000320901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12277" checksum="2250AA9AB1E982EC" modified="2015-12-09" version="1">MFIFFTICILVNSSKEINQDCGIKSNKLLKIIGGKAATQGANAPEVFVSLGSNSLYNLENVYRISRQIIHPEYNEFLVENDIALIQVKISYESYEKIFTIKNSVKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8D6</accession>
    <name>A0A0N4U8D6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Autophagy-related protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7461</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8D6"/>
    <dbReference type="STRING" id="318479.A0A0N4U8D6"/>
    <dbReference type="WBParaSite" id="DME_0000330201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000330201-mRNA-1"/>
        <property type="gene ID" value="DME_0000330201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000330201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25336" checksum="49063EB750EF1279" modified="2015-12-09" version="1">MSEGDAAELKTEYFKFCKAFTSRMIQILVQSRMGEPINQSCLAKPDSSDWFNIRIDEYGEIAAYLRANILKYPPLIPAFTLDFLLYTAEKNILPLESCNVDPLTKNARTINNTQLYHQLGTLLKSIVIAARITPLFRYYVRKQCSETFVILYRVSFEPDLDLGQDRTELCIGCYPSPYGQLSVDLLFRTRMEIIPYVLLILPAFLICNNNNILKLIVWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U910</accession>
    <name>A0A0N4U910_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA_mis_repair domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7556</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U910"/>
    <dbReference type="STRING" id="318479.A0A0N4U910"/>
    <dbReference type="WBParaSite" id="DME_0000355101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000355101-mRNA-1"/>
        <property type="gene ID" value="DME_0000355101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000019">
        <property type="entry name" value="PMS1 homolog 2, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="247"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="446"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000355101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="628" mass="72072" checksum="B666105ED1247DCB" modified="2015-12-09" version="1">MCVEVSRSTIRIISSDVRHRICAGQIVITLSGACKELIENALDANATVIEIRIKSFGVISLEVIDNGSGIHSFDFDSLCKPHATSKLSSLSDFNRLVTLGFRGEALNALCALSSVIIITRHALEKVGTKLVFDGNLKFIFCGQFFFKIGTTVIINNLFETLPVRRKELERSGKKEFTKLLYAIQSFALCRNDVRFLVNNDNNGKHFQILVTPGEKASITDVMISMFGVRVNKSSLLEIVRRVPDESIFSLYGVSEKQCHTIDIIKIHGFISSCMHGQGRSSTDRQFVYFNKRPVDYPKLCKIANEVYQTYNQGQYCIFILFIEVPPEYLDVNISPDKRSVFFEYEKELFALLRSSLLATFEPVLGCTQSLNDRSKNYQSENSSDTFFIKFLYHLCSISDSSFDLNDDVRRYTRTQQSLKFSMSFLRKRLQKVPNRCSKNDFGLMEIIGQFNKGFIIVRLRDELFIVDQHASDEIYNFERFQKRAKIQTQRLISPQTLDIGSVRESVLRDNMEIFNYNGFNFSFNDKFLHNWQFNTSDIDEMLAVLSEFPGIMYRPVKLRRLFASRACRKSIMIGTALNTSQMEKIIRHLGRLDQPWNCPHGRPTLRHLCTIHYRSNSEVGSCSAPHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U923</accession>
    <name>A0A0N4U923_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7570</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U923"/>
    <dbReference type="STRING" id="318479.A0A0N4U923"/>
    <dbReference type="WBParaSite" id="DME_0000356501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000356501-mRNA-1"/>
        <property type="gene ID" value="DME_0000356501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2570713at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="302"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="469"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000356501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="770" mass="88726" checksum="CF39B183D5FF2876" modified="2015-12-09" version="1">VVITTKRGKISKSEPFNDQLEDIKKVGFAIDGVEHKARELIHDDEFEKFMSRIEQEKEQRRKDLEQLERYKPKNIYMENGVLPERSTCDSYDMPWDSHYQIGPETLLLASRGASFNARVRDYRRELWGDGAPLVTEGYLGFRNQDITVRERRRFTDLVREDKEIAKSVANLDREIRMSQSGALRRIQNNIERTVPILKKEDGTFGAIFKTRLKDVAFAHEISNAIFECTVVANPAASVTWFHHESALTNNGKYKIFHDSGQCKLIILNVSTADLGEYSCIATNELGMDRTSAHIFIGDVPAPPGRPEVELCSDTEVFIIWEAPLVANSLEGLIYKLEMRPAGENDHFSEWRLVSDQLDEEAVIVRYLNPLGIYQFRVTAKNAFGWGYPSLTSRIIRTHAKNSLKLQIDLLKQQYHLCILSKPPKSIISKQKLSGITEEEEDKLQNDESLNILESEQLMLSLNDDPNKRFQIISELCRGRFGLIVNASDSRSEVGPFCIAKLLNSSTGRNPSIEFEILKECQQENVVHLIAAFVKNNIYYFFMEKLSENIFERFLRNDYYNEEQVCRSIMQICSALHWIHFKGYTHLDIEPTNVMFTSKRAWSLKIADFGSAVETGTILDESVQLNTYWAAPELQERRQPVTMQSDVWSLGVLTFCLLSGYHPYAAHDSSEDEVKENILRQKCDPNLIHVQATQESLRFVTWALKKDPIRRMRTDEALNHHWFSGELSLVRRRENIKYPSSRLRRTCTFTFNKLNRNNNQTLLSLIPGNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U991</accession>
    <name>A0A0N4U991_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7646</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U991"/>
    <dbReference type="STRING" id="318479.A0A0N4U991"/>
    <dbReference type="WBParaSite" id="DME_0000364101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000364101-mRNA-1"/>
        <property type="gene ID" value="DME_0000364101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF70">
        <property type="entry name" value="PROTEIN WNT-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000364101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42826" checksum="127F40D9C179CA1B" modified="2015-12-09" version="1">MYIRINIPIITLLFIAEIVQAHFYNWLSLALSSTSYYSPSYYGSSNHQQYKMLCERLPGLNPIQITICHQHPFAMPSVGRGARDSVIECQTQFKYERWNCSERINRNPNSSATGFQDLLGRTMRAGIVHAVTKGCSTGNLTECGCDNQPGVQRYTDLDQSLFIGREKFSWGGCSDNSKYGVHFAKQFLDRYERDQYEKDKDIRHLMNLHNNFVGREAIVQNMRKQCRCHGVSGSCEFKTCWLQMPKFNEIGEMLKQRYNHFAVQVAKRAKKRLRRKERSERKKPLRGNEIAYIHKSPNYCERDDSEGILGTKGRECNQSSLNSDSCDLLCCGRGYNTKEESRISQCHCKFVWCCSVKCKTCTEKVLVHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9A1</accession>
    <name>A0A0N4U9A1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7656</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9A1"/>
    <dbReference type="WBParaSite" id="DME_0000365101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000365101-mRNA-1"/>
        <property type="gene ID" value="DME_0000365101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000365101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10498" checksum="63B34E603EF849AD" modified="2015-12-09" version="1">MSKLTELRLKVLRYFNEAMKIQETDTKASNILKRRPNGNDSSKHNPNIETTVLAEEELSKYRRKSTLQEWINGTLKTMAEISEQVVSANDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9N5</accession>
    <name>A0A0N4U9N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7814</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9N5"/>
    <dbReference type="WBParaSite" id="DME_0000380901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000380901-mRNA-1"/>
        <property type="gene ID" value="DME_0000380901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000380901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35842" checksum="427298285753BF38" modified="2016-06-08" version="3">SISSCNTINSEYCRFNAVDLFVFIGLESLGITAILGNISLIIVFVKNNYINKASFILILSLSVADLLHGVVTTFYFYPPIIFKRHQFSSFIMRIFNIVDWVAWSITLTHMSAICIDRLFAVTMYGQYATLITAKRVQIYSIMCWLIFSSINLVFFIFNFCCIIAPLKEHDYYSFGYLNGNGYNIYILIYSPIEAITIFILAITNPITLIQIYKRWKRRLALHNDIPSFLLYDLSNEEEQILNINRNSFWTYIKRKFSNPRKQLILASAMLIEMSIKMGSQFITTQNIKEFTIRKKINRQQQRVMMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9W7</accession>
    <name>A0A0N4U9W7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7912</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9W7"/>
    <dbReference type="STRING" id="318479.A0A0N4U9W7"/>
    <dbReference type="WBParaSite" id="DME_0000390701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000390701-mRNA-1"/>
        <property type="gene ID" value="DME_0000390701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000390701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70631" checksum="AD7FCCA877AAD7E5" modified="2015-12-09" version="1">MHRRPLFDDNSSHAIHTILPLREIMKNHANLPAGASCFECENHKDGFCEWAACQCYLETPSTSINSGGGSLDFSDRIWLGCSRQKMPQVFSALNALNETLISKLWIWDSLINIIPTDMFAQVRPRILSIERSGLSVFRIGAFANIGRRLRVLQLKNNILKKIDAAMFKDLDRLKILDLSGNKLSLITKDQLSSLKDLETLIISDNQLSYIENGTFSALNNLKMLNLANNKLTNITRDTFANLISLEHLNLQNNNIMDLDWNAFTHMRNLKTLNLGNNHISKVDIRGLKSLEKLFLNNNSIQSLKNVSLRTLPNLSVLNLDRNAITQIFDGDLHSLGESVRLQSLSMAANQIKNIEARAFKPVHRLTKLSLQDNQISILTTNEGEAKISFLHPLKKVTDLFLSNNRLSRISDADLSSLHSLKILAVDHNEIEKIDVRAFVELPLNRLYLNHNRLQFIDKGVLEMLPSDLDVIDISGNPWQCICGEEWINDFLIPFGDKVITDGSMGCIETKICLDRINEESEHSIWITVIASILAAASLCMLAVIALMCSEWKFKLSKTLSSDRLRLIPDGGSSSSLPHDSCIEPLISSGSIQKPFLVSSFRSSDFDRSSNGWDTAANGIEKKRVRFNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBE3</accession>
    <name>A0A0N4UBE3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8402</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBE3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBE3"/>
    <dbReference type="WBParaSite" id="DME_0000451901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000451901-mRNA-1"/>
        <property type="gene ID" value="DME_0000451901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000451901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31617" checksum="BE214283DD395A85" modified="2015-12-09" version="1">MLDPRQIFMSPFMYNIDPTTLALLEKPPSQSNGGGKMTLGNSFRISDILESSENKANTSGEREPTPLGEEERSVSAESHRSGSPHSSASCSKKARKARTIFTDKQLQELEATFDKQKYLSVQDRMDLAQRMGLSDTQVKTWYQNRRTKWKRQAAVGMDLLNEASNVAAVQQLLRTNPYWANYMAATSLSQPRFFPMQNAVLQGPLPLALAGTVSNSLPPPQALTSINASATISSSTLTPPSLTSTALPLAMFPFHLPSAGYTLSLSHCNLPESSKTPSISETKSETKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBH2</accession>
    <name>A0A0N4UBH2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Disks large homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS8433</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBH2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBH2"/>
    <dbReference type="WBParaSite" id="DME_0000455001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000455001-mRNA-1"/>
        <property type="gene ID" value="DME_0000455001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11861">
        <property type="entry name" value="SH3_DLG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000048">
        <property type="entry name" value="disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000004">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="17">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="181"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="339"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="480"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="590"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="15">
        <location>
            <begin position="735"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN58460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000455001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="926" mass="103329" checksum="63D468EBDE5EE7AF" modified="2015-12-09" version="1">MPVRRSGEAHRALEQLEEYHASLVSSTSSELKREIEKLISNFKGALFQSLIDIQDLYEDTLLNERKSITQKAIETRRIAERWELHPPFGHVTKIAPLASVDSGFHYIDQQSVNAPFSTSTDIPIHSSYSIHEQKRQYTSNDGWRTTETVTSHTAAVDQKQYIQFQANGHTDLDSSDYEMEEVVLEKGHTGLGFSIAGGQDQPYIDGDPCIYVTNIIHGGAAASDGRMKIGDIIMRVNNTDCSRAPHEVTVNALKNAGNVVRLILKRRRPNLSERDINISGSTASYYPRGRASPFHESSGASVPNYSPPAPPSHGSYSNIAIQRPLREVEKLERIPGIQKIDLYKGQRGLGFSIAGGIGNEHIAGDNGIYVTKIIDGGAAYHDGRLRVGDKLLAVDDVLLENVTHEFAVNTLKQTAAKVTLYYLKNPHPELIPITLDDSVNRSMGALSTPARSGGSSVHHDSFDAIGHQMVSHEIPLVPRSISLNRGMQGLGFNIVGGEEGEPIYISYVLPGGVADLSGNVKKGDVLLQVNNTNLCNATHTEAARALKEATNPVILTLQYRPQDYAQFEAKIDQLRKDMMSGGIITYGLPTKELYVRALFDYDPSRDVGVPHRALSFCYGDILHITNTTDDDWWTARLVGENGEEGIDGIIPSKRRVEKKERQRRKQVNFNAGSQSLGRSGMEGRRGSRSQLSFSRKFPFVKSTEKLNEFTDNELGGAEEPIPTYVAVERLQINYPRPVIILGALKDRINDELVLRERDRFSSCVPHTSRPPKPNEIDGRDYHFVSKEQMQEDVKNNEFIEAGQFQDNLYGTSISSVREVAEMGRHCILDVSGNAIRRLQTIANIHPIAIFVKPQHYRQIMEWDNTINEDEAINQFQRCQRIEQNFGDLFTAVVAGHSLDDLVRRVLNVISEQSQPYAWVPSRAQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBL3</accession>
    <name>A0A0N4UBL3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8481</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBL3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBL3"/>
    <dbReference type="WBParaSite" id="DME_0000459801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000459801-mRNA-1"/>
        <property type="gene ID" value="DME_0000459801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000459801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24634" checksum="E744C48B76292F12" modified="2015-12-09" version="1">MSEFVDLSLDEIIALQKSKAKRGGRNFGGTRGVKRRLNRRFPDRRTQGNRFQRNITKRVGEVCIVQVSNLGPLVTTADLQELFSEHPYVDVAMQYGDDGKTLGTAVVIFSTFEQGMRLKRQFAGVKLDGRVMDIFVSSSDQKARINSVQRGRITKRRIASQRGKKIGSKMGKFNRSFRFSKRQNENNTRKQMTTEELDRDLDAYMRGSKHAKIVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBN0</accession>
    <name>A0A0N4UBN0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8503</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBN0"/>
    <dbReference type="WBParaSite" id="DME_0000462001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000462001-mRNA-1"/>
        <property type="gene ID" value="DME_0000462001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000462001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7880" checksum="C0D1E8B79D77FF77" modified="2015-12-09" version="1">MRVINFVDTSTWNMVSISDFQVRQWYYICVEWDNFNRHNESTETECRTLQTVIIVSLGDRSGSLLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ1</accession>
    <name>A0A0N4UBZ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8636</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ1"/>
    <dbReference type="WBParaSite" id="DME_0000475301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000475301-mRNA-1"/>
        <property type="gene ID" value="DME_0000475301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057322">
        <property type="entry name" value="Rgr-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056879">
        <property type="entry name" value="RM3_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25308">
        <property type="entry name" value="Rgr-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25065">
        <property type="entry name" value="RM3_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM3" evidence="10">
        <location>
            <begin position="377"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="9">
        <location>
            <begin position="760"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Rgr-1 C-terminal" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000475301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1304" mass="148288" checksum="4A888C4B07CAFEFF" modified="2015-12-09" version="1">MSRKIYGDMEDEEEYMKPMLPTVPEKCGPPVISLGHLIEFAVQQIFHELTVLSEFIVQFAHSTRTLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFIDTADRLVQLAREDLIHARVHDLLEKPIEHISICVRLDNLITYDEVGLQIFFLQSRFIRPSEITAREQASILARLNQVLQTRISICAKRMSPRITSVLIKNGMVTLTVPGEFSVSLSLLGERDTTKWTLLNIKILVEDYEIGYGTKLVHPLQVNMLHNVLQLRMDKADDAISEVYNFLHSFAQSLQLDVLYCQATQAVRGPMRQYTTIDRYDRTQGILIISYWLKKTHHNRFSSQYRIKISSSADNINSGLRVRHYPDGKNLPKIDDRTGRLSISGILSETVVIRCRERLLQIRECLKSLKPFSPVSLTGKAAPTLTYPLLGPESNQDEMLIISVNGFSGDVLVIVRALVLYSSRLELCELERFLNDRSSIQRISSLIYRLRILLMMERYRKSIASLAVRIVPEKTLSVLLPNISSLPSDRLCLQFVKEDAFFLIISWKSDDIKGFDIDMYLFCNTERKTNMIRLHPSQVLSSSPSSNFSSYDKSIGMPSVQRKRWIGNVKELSSAIAIIDDRIAFMRICEELSKRCVSYQPVTKEPVVGGLLLQISDFSGALPSASKEFFSSMTNCCLRLDTRSRVIWPFECTLTETPLIADIPGSANVLGKRSRTKLTVMEINGSGGISSLNTSESVSIHMLDRLTIFSHMYEPVREFADAYYSYYNQYCNIVAFTYHKLVIAYGTNRNYLVIISWKSQKTTKPYFYLTLGIWPNQRNLNNKCEQMNENVWNPHILMHQRLQEQFNRHRSLCQLMQYLIDTISPLCCLHNFIHMRLHSLRAYCQLSNLEPSLPITLQANLSVIDEHTIRLLYGNIHLEFLLVGGYRVGVRDCGRGGVSAHRLKTFCNKFVSPEMRSANDEPSAYLNWMHSSSSGPGSLPPHQITRSPASRIAASPMSYLSLSVPPADTVPSPLRHPQGDHLRCRSPILIDHGALQTMTAINDSDYLFSLSYLSRLGPALESYRRDNRGNSPLPAIHLKSLLTTPELIRISVSGAVPPSPRNESFLAVLNVYLDDDTMSLKLRIDFENSSPPSESDLRIFERYFKRYIARSGNEIAFIAFSNACRIVSPGIFSSIARIMEAQMDWSENSPWRPSLQLTMWNQEGSTSRARISPGIAIDQTNTNILIPLCLRPTKRKDGERNADASKYVIPLIYNTQTNMITRRNSEEDSSNASTILLSITEQYSHTTECPLWFAVNSLAYKFVPSNTTSSIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC63</accession>
    <name>A0A0N4UC63_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC63"/>
    <dbReference type="WBParaSite" id="DME_0000484201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000484201-mRNA-1"/>
        <property type="gene ID" value="DME_0000484201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873999at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057233">
        <property type="entry name" value="DUF7911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25492">
        <property type="entry name" value="DUF7911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079478" evidence="1">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000484201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="31092" checksum="E252ED1F911D8787" modified="2015-12-09" version="1">MGFLLSYSILLCIPFVFSLYNNIIKNTLYIYNNELTNNANRFLKNIKDDFIVYGVTQDCKIFFVERNNINLFNKLKIDFMNTYCYPNQIKLHLQQGIHQLSFILFIRQTHNRICLLNIEMPHLDVIKMVHNKNFSYSLYSSLPYATCSHLKHQSFILNPNLSFMDTTFSDIVYFVNEKSAGNIWDVQQFQLIMRNDMINLIDLEKKLFLEESHHFLQAKHYIFHLDLNNSLLYSMNRHVKNLLSECAFDLLFRQVLKEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCG5</accession>
    <name>A0A0N4UCG5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 830</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8759</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UCG5"/>
    <dbReference type="WBParaSite" id="DME_0000496001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000496001-mRNA-1"/>
        <property type="gene ID" value="DME_0000496001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZNF380 coiled-coil" evidence="9">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000496001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33680" checksum="92DFD517B81EB830" modified="2015-12-09" version="1">MQLSSEITLERLEEEPQATAGSRLLQQRQIDVDLNSEQVEMSAALPNPAIAKDLKDGNLLCLVKSKLWIAHSNGRKHRENIAILKKNFIATTNNNQQQNDDKRNNKKRNLNDQNALSVSSPKKFKSNNDDIKSTVDPVPVSSLQKREEPKIETKKIGKKIIDGVPEGFFDDEKLNSRVVETIEKKANMEDEYANFMKELHEAKQKHDEKEIMEEEISGIKRDIEHIDEQIECWRRVNKYEVKLEELRKKFRQQRANSPSISANTMECDVPTLEDDDSNIDEFMDWRRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCJ1</accession>
    <name>A0A0N4UCJ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS8787</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCJ1"/>
    <dbReference type="WBParaSite" id="DME_0000498801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000498801-mRNA-1"/>
        <property type="gene ID" value="DME_0000498801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="71"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="252"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN58814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000498801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48098" checksum="49CEF3CE94A6BFF8" modified="2015-12-09" version="1">MTDANFNAQNVEDQKDYQGTNASAVDADGLIESNWTQVSETFDDMNLKEQLLRGIYAFGFEKPSAIQQRAIVPCISRRDVIAQAQSGTGKTATFSISVLQNIDENLPEVQALVMAPTRELAQQIQKVMVSLGEYLGVKCHASIGGTNVRDDQRKLESGVHVVIGTPGRVSDMIQRNSLVTASIKMFVLDEADEMLSRGFKDQIYDVFIRMPNNVQVVLLSATMPNEVLEVTNRFMNDPIRILVKKEELTLEGIRQFYIDIKKEEYKFETLTDLYSTVNVTQAVIFCNTRRKVDNLASQLKDENYTVSCMHGEMDQSDRDLIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRYPIPVQCFGIFSIGRSGRFGRKGVAINFVTEADFRLLKDIENFYNTQIEEMPSDIANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCN1</accession>
    <name>A0A0N4UCN1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8831</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCN1"/>
    <dbReference type="WBParaSite" id="DME_0000503201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000503201-mRNA-1"/>
        <property type="gene ID" value="DME_0000503201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000503201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31416" checksum="BD093D0E5112FEF3" modified="2015-12-09" version="1">MESMLSITNYFHPIFKKRLVKNQPKAKIISNGILQKIDPQIIPKEIHSEENPIPHYASVYEQKNIPSLKNNSQTITESNTSIYTEIPISSNCANISFPICSKLAVKDFLLKRYRTNLNQKSSIPVVPLIPPHSYKLSGREVSEEISPNHADCAQMQIPHRKRHISFIENVCENNRKVQEFNKRIKFSSGDKKIDDSILVIPNDAKSVENVQSLSCSEIMKESDILEAACATGQYGSVRNRRKEHKEHGFYSYPEDEIEFYLFWHGQPVRKPDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCW2</accession>
    <name>A0A0N4UCW2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8925</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCW2"/>
    <dbReference type="STRING" id="318479.A0A0N4UCW2"/>
    <dbReference type="WBParaSite" id="DME_0000512601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000512601-mRNA-1"/>
        <property type="gene ID" value="DME_0000512601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7721051at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF880">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000512601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29397" checksum="0326470FF0EE1DA0" modified="2015-12-09" version="1">MNGVTGSNEIFLKRNIIRAKRFIRQSWTYSRIYNQIRDEYGNYIIPYVISGPYGAHQYAVIYGAFQAIARNTCIRFKPRTFETNFIDLQNRYGEGCWSWIGKRGGQSVVKLESSNLQNCVRHQTVMHELFHAIGLSHEHVRADRDQFVRIIYSNIRPDCLYNFEKRNSQTFGFPYDYQSIMHYNKFMCQRTRGAITISAPYHFMNIIGIGNDASPIDYYKVCALYNCHYCMGQRFNLAEVVRAVQARAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD49</accession>
    <name>A0A0N4UD49_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hcy-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9032</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD49"/>
    <dbReference type="STRING" id="318479.A0A0N4UD49"/>
    <dbReference type="WBParaSite" id="DME_0000523301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000523301-mRNA-1"/>
        <property type="gene ID" value="DME_0000523301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000523301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26069" checksum="3C568F61E4B3D87C" modified="2015-12-09" version="1">MRTFVFMKSVGLARRAVRECSSSRPIQIIGAIGSYATILFDGSEYNGHYIDTIDEKTVVDYFLQQSKPLLQADLKILAFETIPAFKEALCILQALDRMPDDIKCWISFSCKNGQLVNHGENFAECVKKIIVHPKLIAIGVNCTKPSFITSLLNSAQKYLGEKFFVVYPNSGEKYDAKTKRWLPPEDEDIDFDKMIPEWKTLGAKLIGGCCRMKPEDIRKISAVIAFLNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDY3</accession>
    <name>A0A0N4UDY3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9302</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDY3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDY3"/>
    <dbReference type="WBParaSite" id="DME_0000556101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556101-mRNA-1"/>
        <property type="gene ID" value="DME_0000556101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867217at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF4">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="115"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57657" checksum="439F2AD41DCBD936" modified="2016-06-08" version="2">MNNVDELNFINSFFAVLCVNRVNAFFVVDNARLDASAILTYEDISEDDCSKICGKNRDKNGRFILCSAFTYDHSTFKCLIHQTKSIPEGDSQIENIPEHRYFEKFCIDEKLPVECADTQFLRAEQSVLIGFARNVSLTANLAECVTHCLMEKFECKSAMYFYEEGECITNIESASTQPNSFAKEENDKVIYFQNGCTESMKFQRKYEAIKDHLDEQFNTHNLHNEEMITDFPIENDENENAKENDDYQMNRNEKEEILKDEKIATATTTTATITTKISEYQIVQSHNVVNDSKNLQIEDETKLKIANEQKNKDEIITTGKYLKKLKMQIIKSDSPRNNIKQKNKYKTHPRIITTKKYEKHEYFSQWSEWPPCKKIGEKRVRYRKCYDLRLCLGALMEINPVERNKLNITPFTPLPFEGILEETIGATQKTMVNRNNTTESPNNHNQIWSSWAGECQAFTSGQPCKDHEMIGFESRECIAKDPNRCVGPFFRYCTIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE15</accession>
    <name>A0A0N4UE15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS640</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE15"/>
    <dbReference type="STRING" id="318479.A0A0N4UE15"/>
    <dbReference type="WBParaSite" id="DME_0000559501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000559501-mRNA-1"/>
        <property type="gene ID" value="DME_0000559501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000559501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="779" mass="88515" checksum="E23E8A36D4FD8247" modified="2015-12-09" version="1">MEDDNAIDIFKWMFNTEMENDLFDEMFLQNAKIRANILAIESRDAPIEPIIIILERVHVETAEVAEEKYAFILSYKTGSIKMFARNAKQREKWMIRLSTSSHRIAQAELDEIIDNFNSTVPSSLMPSPSSTDCFRLFYLTEPIKKLHNFSISQPMSLHSRKIRCEEIMWESKLSLILPQQLLKLFLKWSNELKEFIENRLWVVPNGYLEAAHNCLRHISANQETYINSLEFIESYSGPSFRSSSEKFRVAFASVPTNLHLQQFVVEKITHDYLTCGAVCAIPLRFMHGGLSRLRVDLHSSINDPVCIDHMLDSRFFHRRNSLQAAKSVIGELSQQAEMDWNFTELKSTEKVGLCLLAEIKQLKENLVDLIESFPNVVRLIDFFREWNQLSDHHCGKINRTMVDGLDSQLDNLEATIISLNTKMAVLCSARDNEDTWKDYEKNTKQTLNSCLDILLQIIDNIQNAQFLGLILALKRSSDCQFFFNIQLRSDLVLSQAITIVSTALLSAIENNIAEWNVNPPLITIFSFLSCYGDERGMMEDARECWASFQDRVRFKLVLSSSSINSTCIPTVSGDRSKIIVHLPLPQNIFQSLPEDLKSGQLFTVCSIFWNLGINHEATFAQSIAGDCSLEETINIIAGRALQAYADCNSSSSQSVKNLIAELNLAISVSPSNKNMVIFRLAMIANFALNGIPILCCKSGKDRTSMALTLEEGRIIRENCGVSGDQMGEMIVCLRRDGVRRENCRKNIGKPLYSFSPFQMHFIPKEFRPPSGTYAQGIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEB9</accession>
    <name>A0A0N4UEB9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS762</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEB9"/>
    <dbReference type="WBParaSite" id="DME_0000571701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000571701-mRNA-1"/>
        <property type="gene ID" value="DME_0000571701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6093641at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229901" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000571701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17591" checksum="40DBB819A85CA5ED" modified="2015-12-09" version="1">MGHSLVVFVDIIPVTSALDPMYRSAMTGGPHKDSKMNSIIKAKYASPTIDNLWEKILDDILLYYIAGRSAKLLKKSLDSMEGSGFGGLKKKSIPEGSPENFQDYSSRYERSLDLLEGEGFGNMEKKRNLFKKSLDVLDGSGFGGLRKRSSRFADKSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEM6</accession>
    <name>A0A0N4UEM6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS831</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEM6"/>
    <dbReference type="STRING" id="318479.A0A0N4UEM6"/>
    <dbReference type="WBParaSite" id="DME_0000583701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000583701-mRNA-1"/>
        <property type="gene ID" value="DME_0000583701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679:SF1">
        <property type="entry name" value="GLUTAREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000583701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13507" checksum="031CE310D5C0B875" modified="2016-06-08" version="2">MGNSLKKHMNISQIESEIREHPVVIYTKSMCAYCKRAKDLLTAVNVAYEEKNLDSMQADSPDIYQSYVNGLVYLTRQTSVPQIFICGKFIGGFSDLEQLKKADKLFELINECSTMKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFF7</accession>
    <name>A0A0N4UFF7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9463</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFF7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFF7"/>
    <dbReference type="WBParaSite" id="DME_0000616701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616701-mRNA-1"/>
        <property type="gene ID" value="DME_0000616701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000145">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000124">
        <property type="entry name" value="Galectin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="147"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28937" checksum="2614B85326C5E7AE" modified="2015-12-09" version="1">MSEQKSYPIPYRSQLQEKIEPGQTLIVKGSTIDESQRFTLNLHCKTADFSGNDVPLHMSIRFDEGKIVLNTFSNGEWGKEERKSNPFKRGEAFDIRIRAHDDRFQISCDQKEFKNYEHRLPLSSITHLSVDGDLYLNQVHWGGKYYAKRFLINLLKKNGDIALHFNPRFDEKVVVRNALQSNEWGNEEKEGKMPFEKGVGFDLSIKNEEYAFQIFVNDVRFASFAHRSDPHDISGLQIQGDLELTGIQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFS2</accession>
    <name>A0A0N4UFS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PRKCSH_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1198</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFS2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFS2"/>
    <dbReference type="WBParaSite" id="DME_0000630101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000630101-mRNA-1"/>
        <property type="gene ID" value="DME_0000630101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="3">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000630101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16625" checksum="27BC36967C023141" modified="2015-12-09" version="1">MFLSNFGVELCHCFSEVADFLKDDFDTDLAWMPLKNKCLEINEGHYIYKLCLFDKASQIDSGGGPEINLGTWSKWSSGTAGVGMQIYERGQSCWNGPDRSAHITVECGEDTKLIEVSEPSKCEYHFVLHTPAACPDPVTLQDDEGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFS6</accession>
    <name>A0A0N4UFS6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1202</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFS6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFS6"/>
    <dbReference type="WBParaSite" id="DME_0000630501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000630501-mRNA-1"/>
        <property type="gene ID" value="DME_0000630501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14568">
        <property type="entry name" value="DSP_MKP_classIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="71"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000630501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55745" checksum="60D35C71039697EA" modified="2016-06-08" version="2">MSPELNFGFRLELLDCYRLFFSMMIKSNGFNDFHIRFPELCESSNEMQKITEVPNYISQPCVAATYLTVNGPTKILPFLYLGSQQDAMNEKLLKVCGIEYIINLSVNCPQPDHFKDDEHFLRIPVNDSYQDKLLPYFEEAFKFLDKVSQNGSNVLLHCLAGISRSPTLAIAYIMRRNKWTSDQAYRYVKSKRPSISPNFNFMGQLLEYESQLREEFRLALSPSSSCEYSPSPLNQSTDTKNDEVTSCDQISKKIARPQNFWRNEQWQMSCKMNENGKRTLGICLLDRPRALDGLRSRKSVNENLPSPSTEFQKLSFTPSPIDDFAVSNPFFAIPQSIPGTSKLPGSPTLLSVENPTFQHLQSAKICSSNVRGNNPTCFFTRITHCIKKRACSSHSSKRSISPSSTSSSPLNSASLCCNISSSNHLSPMVETPTPPSDDFTDSPESGFVEDETATNCMRKVTNIMAGNENLMTSSESYRDADRDSVSSASSLEIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG14</accession>
    <name>A0A0N4UG14_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9517</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG14"/>
    <dbReference type="STRING" id="318479.A0A0N4UG14"/>
    <dbReference type="WBParaSite" id="DME_0000640601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000640601-mRNA-1"/>
        <property type="gene ID" value="DME_0000640601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140006">
        <property type="term" value="F:histone H3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="14">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000640601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22584" checksum="1D3F1FFF5FD1489D" modified="2015-12-09" version="1">MMNDVKDVRVKESGHRGQVEEGMLIVEGDGDVADDHWVLDDRMKRMIMDLQRHWLTDYQQSREKLLVEMTERLHQEFLSDQQKIRTELLTQFKDELDATRTELEEKYRESLKNELAKAAEKHRKEISSCKKKQWCWQCEAEAIYHCCWNTAYCSVECQQNHWSTHRKYCRRKKQQSSSATVTANQPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG81</accession>
    <name>A0A0N4UG81_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UNC80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9597</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG81"/>
    <dbReference type="STRING" id="318479.A0A0N4UG81"/>
    <dbReference type="WBParaSite" id="DME_0000648601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000648601-mRNA-1"/>
        <property type="gene ID" value="DME_0000648601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000648601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63838" checksum="E6646887F96D263F" modified="2015-12-09" version="1">TFERVVVQNILHGLSPSLSDAIGSVSRWRFVRAAFPHIVQCCATLLSEAANSKGSSPLSGPLSKILYILHWLLLDSANECCDAESRKSLIDSGEWNAHSVRRYTFSISSIQLFVYLITPLISVINEENISSHIRLESGLKIWQSLWQYRQPEVLCFCAPVKQRRSLIPFITVAKKSPRNSVVQGIYLGDEKETTRRFSTVSAQFANFPQFTLPPAKPPRSDLAVLESLGKKADKHKKLRSINNYKNANSKSKSKAEIFNDNDTKSRVVRSVSEYHDDNLALDIRQKFAKSKTTTFDISPTVTRGMEEIDMALKLVENNSLSDMMADLSEKAPLVQLQEICSNISNDIEIPLQNACDITCGKCKTVIFRKGSLVGTCKCSKDVPISSSKLNIVPTRSSSEQNSSVMSCERSTDETISSIHTVIRRPTIAIENEIIKKEYDPLENLSCGSEIVQQNNTDPQEASYLDIAVIRCLLIKQWSEDGIHWALKYLINRLNDIERYRNTQDGMFRSRANSAPTTPHLKVVQCRTDIRQNLPTTVSRAPNWDDLQLNNVISGFSQFMKNSDPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGX1</accession>
    <name>A0A0N4UGX1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1374</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGX1"/>
    <dbReference type="STRING" id="318479.A0A0N4UGX1"/>
    <dbReference type="WBParaSite" id="DME_0000676001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000676001-mRNA-1"/>
        <property type="gene ID" value="DME_0000676001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000676001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17139" checksum="20587991D9714F2F" modified="2015-12-09" version="1">MQQKSLGCKCHFDLSHHSILFHRVKTRKKEKDFFRTVWFQNRRAKWRRQDKAESSAIAELPPVRPSGPTGIPSWTWMTHPEEFSGLMHPFVTQPNAFPPDMLQTVKAQRSSFCFGYLPAPHYTGTQSFPDFEIPNGPSILQTDKTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHG3</accession>
    <name>A0A0N4UHG3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9791</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHG3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHG3"/>
    <dbReference type="WBParaSite" id="DME_0000699201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000699201-mRNA-1"/>
        <property type="gene ID" value="DME_0000699201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000699201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44344" checksum="6349FFA559584C7E" modified="2015-12-09" version="1">MAKKFAIAISIDLKSAAINTYHNVRKMLWHFSNMRENGVIRIIHFIVGWSVCLFFNAFAIIQMAIIWWKNKNAFAKPKILPKPDALENWIHGKAKLSYNLNQTSSQEVTIHYVEQGDLMSPLLLMVHGFPDFWYSWRFQIKHFAKSYHVVAVDMRGYNESEAPVGIEHYQAHLVAKDIVELIQYLGYNGGVLVAHDWGGAIAWHIAAAHPEVVKRLIILNGPHPLAFQQHLRTSLSQFIKYIYFFQMPIIPETFISLDNFARLIQTIRGSKGLINKENFTDEDEKALLYTFSSKDKLTGPINYYRASFQMPTNFSIFKNLIKAKTLILWGINDHFLEKKIAEYSSSYCEMSQLRFVENASHWPHIDQPEQVNMFIENFLQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHW9</accession>
    <name>A0A0N4UHW9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1640</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000027">
        <property type="protein sequence ID" value="VDN51667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHW9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHW9"/>
    <dbReference type="WBParaSite" id="DME_0000716901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000716901-mRNA-1"/>
        <property type="gene ID" value="DME_0000716901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9975356at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041428">
        <property type="entry name" value="PHsplit_syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18012">
        <property type="entry name" value="PH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000716901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56922" checksum="BD4F61EF62293965" modified="2015-12-09" version="1">MVLLSDGKGRGQSARLQLTKDSLTVQVIAGSFYPEDLNETAPESDTGIRIVKLQKKKDGGLGLSIKGGMDGNQQVPVVISKIFPNMPAEESGLLYVGDVIAEVNNQIVDGKTHDEVVQMLRDAGDEVVLSVRHYTYIAPPADSLRLKSKSSLNRLYEPNIWKSALKSQSTNILNKNDKLGDNDEMMDEAPEGWRTLIKIPLPMAFITRYLWGTDKIRNNAFEVRAVDGASTGIIHCEDKGTLDQWIKHIQNHITQLNQKSINLSNKYLHKNEQIIYIGWVSERLPEEHFEDPRQRWEPRFIILKGGELCIFESPPLNSNDLNKCVSLYKIYDTAFKIIGKGKSGLDKRDHCFWIETSLNGIKHYLSTETHQQFSQFENAYHRCLYSTVNNLQTRTFACNYEGRPCGLVIDIKQGISLYDIPTKRYTWQYRFMDLDSSSDDGKIRLRLAFCNERGKNNENGLQIKDIDSDEVLSIVYTMHAFYITKIIASDPEYLKTIPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIT2</accession>
    <name>A0A0N4UIT2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1796</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIT2"/>
    <dbReference type="WBParaSite" id="DME_0000752901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000752901-mRNA-1"/>
        <property type="gene ID" value="DME_0000752901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000752901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8772" checksum="1E683035EE8A2594" modified="2015-12-09" version="1">MIAENEENGKVREGRRAKASPTGQRSVGMSGERDDGYGARSSLKILQGIDERRRPRDQPTEKRRMHKRASMPACNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIW0</accession>
    <name>A0A0N4UIW0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1828</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIW0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIW0"/>
    <dbReference type="WBParaSite" id="DME_0000756101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000756101-mRNA-1"/>
        <property type="gene ID" value="DME_0000756101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413649at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000001">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000564">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08560">
        <property type="entry name" value="DUF1757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1312"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="462"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="356"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="644"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="927"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000756101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1346" mass="154746" checksum="3B62E8EBE0D879BD" modified="2015-12-09" version="1">MGRLLTLELENFKSYKGKQIIGPFQQFTAIIGPNGTGKSNLMDAICFVLGEKANNLRVKKLHDLIHGAPVGKAVANKCVVTMNYENDDKKMRSFTRSVTGSGSEYRVDGKLVTPQQYSHELEQIHIFIKAKNFFVYQGQVEQVAMKNPKELTQLFEEISRSCEFQSDYDRLKAEMNKAEEDAAFNLNKRRGIAQEKREAKMEKDEAEKYQMLKDELASKQRLMYLLQLYHAEKSANNASEEFDRRKETMAELSLKKKECDESVSSKTRDTKKLNTELHKMEQKIQDKVLAVQEIEQKKQECEKKLADESQQLDMQLSESQVNEYYSLKGEATKRCGLMDMELNKLLQEHETDRNTLQFEQRRLVQASERVKNKENEIERNARHAEQLAENIESQTSLLEDEKKNLQHLEQQVRDSKERLKKVNIELTEVSKQLADAHGDTAESERNRKRNEAIENLKRVFPDRVYGRLVDLCQPSHRRFQIAITKVLAKNMMSIVCDTDETARESIVYLKEQRMAPETFLPLSVLDVHPIKEKLRELTEPKGVKLVFDVIQCNVPVARKALQFACGNALVCETAEDAKYLAYGSASDRYKAIALDGTLFQRSGLISGGGQELRARARKWDENAIRKLKDRRAALLDEDQQLHRTRKKELDVEMKRNQLVQLEERIRATRKERLKIENQTMQRLETELETLNSEHSLIQPRIDEIEQRMSDRNIQIERLQSKRDTVTDEVFRDFCARINIKDIRQYEQREMRFHEEMQEQLKKFDNELDRLRNELEYLRSEDKRLKEKQEADKVKCLTKELSSLIRCEEDEQQKLRTLETEFEEMKMAAIRKKAVVEDCECEISGLKKAAQQAAREVSAAEKILLALDQTVIRRRNERHSLLHYCKMNGIEVPLIKGSLADVDADEPIASSSGEQLLPLISQEQIDREAKIKINYKSLSDNLKELDDEEEIKKAVDKINKDVAEAQAKISRINAPNMKARERMEIVKEKEAETTEECELARKKARKARQFFEKVKTDRYRRFQECFEPVSQKIDEIYKQLSRNESAQAFLGEENMEEPYLEGIAYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHARNPSPFFILDEVDAALDNTNIGKVASFICERARVDMQLIVISLKEEFYNKADAMIGIYPQPANYTVSGILTLDLTPYKQSQSDSFAEESMSTAWLKNFVGLKQSDYEMLKVPRPRVEYGIHMTVRAMQAGALVGSIFGPLMVIYRGGKLVERNGDISNLKDAVADGGSCGAIIGAMLGPVLTYFALRNMNSIRVYDHCYRLRFNSEQLIKDRTCLLGAGIGYLSSGTLGFVVGVDLAYVASKILSSVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJB1</accession>
    <name>A0A0N4UJB1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AcidPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10146</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJB1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJB1"/>
    <dbReference type="WBParaSite" id="DME_0000773601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000773601-mRNA-1"/>
        <property type="gene ID" value="DME_0000773601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000773601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24551" checksum="72334CDA7C9823BE" modified="2015-12-09" version="1">MEYFVNPVNRGFFCNDNSIYFPYKQEIINSTLLAFIIFVMIVVIVSFSYSNCLHVAKIANISVHCLFAIFINLYICQLTKLSVGRLRPHFLAVCRPNIDLEACANTLKYIETYNCTGPYNVVRQARLSFFSGHASIAMTALYLQARFPRHLYGLGSLPLIQMFVLSIALFVGFTRIRDNSHHPSDVLAGYIFGTIVSIIAVFLFLPPMFSCGSYLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF3</accession>
    <name>A0A0N4UJF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1985</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJF3"/>
    <dbReference type="WBParaSite" id="DME_0000778801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000778801-mRNA-1"/>
        <property type="gene ID" value="DME_0000778801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000066">
        <property type="entry name" value="Na/Ca eXchangers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000004">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="58"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="341"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000778801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58606" checksum="E9817B56CF48968B" modified="2015-12-09" version="1">MKYQQVLSFIVSFKLFFSIKENIKLLVKKNETSDDSFPSDLFTIEQRKKGAIILHFCGLIYMFIALSIVCDEYFVPSLSVLTERLMISDDVAGATFMAAGGSAPEFFTSVFGLFLTHNNVGVGTIVGSATFNILCVLSCCALFSREMLQLTWWPLFRDVFFYMFALLFLVFFFFDEIIEWHEALTMFLIYILYAVAMKYNNHLEKMFKYKLLHQSRVRIFPTNNKLDKEIIHFQSTSRRRNSERRKSIPVLHSGALFRGGISSFVQQNDADNEYLSKNRKNFSVFKHIYRIFFFNSNEKPVDISWPNTIKSRIVYLIVAPIIIPLYFTLADTKKPESKKYYIWTFIGSILWIAFFSYLMVWWAKIIGETLGINNEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDICVGLPIPWLLHFIIHGLSHMSLVPVSVSSKGLICSVGMLFIMLFVLIIAIAISGWRMNKLFGIIMIVSYILLCLFSIFLEMNIIRCPLRIENSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJR4</accession>
    <name>A0A0N4UJR4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2037</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJR4"/>
    <dbReference type="WBParaSite" id="DME_0000791201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000791201-mRNA-1"/>
        <property type="gene ID" value="DME_0000791201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836300at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000791201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40818" checksum="D5BD1CA838AB72C2" modified="2015-12-09" version="1">MEHQISSISFINFACTTIIITRLINADTPSFAQTTFDLSPDLPIESVIDSAPEYHEFNSDHRNNSIGSPSSLSHLEQPTYSLHTRKNDAKSQALFYKQFPASRTPLPYAVFLTPLPHHVFSSTIAPYHTTLSRLSFVASSPYPPFFMLPQYPVFSSTFTFVTPRIPQNTHKQRFSPPAYHAKIYSSQIRIPLAKKVPASSYSRHSNSPSLWFNDYYDISNCSRNYQWISLEFRKKFPKSTTRSGKDQNFSEILRKSLENCEKKTKYDHWEKISSVIPKIKLSYSDREDCRNGLVQEKIACINLFSYSCQFIVEKIKFRLVPTRKIIQEIRLIEDGEEKCQKAIRIAKKKRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJR5</accession>
    <name>A0A0N4UJR5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2038</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJR5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJR5"/>
    <dbReference type="WBParaSite" id="DME_0000791301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000791301-mRNA-1"/>
        <property type="gene ID" value="DME_0000791301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867840at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF26">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="514"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000791301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="919" mass="103004" checksum="D7257672B84725D7" modified="2015-12-09" version="1">MNSSVVYGRLIGLEDIFAQCSIQDCARLLNEFSTRINRIAEKNECMRIQSDGILVVSGAPNFREDHAKLAVKFACDVQALVKSFCDSTTADLGFRSGIESGAVICGTIGTNKWHYDVVGIGVFLADNAKEQVVDDYNMENYGCYWRILPEKASALPSSLLFPCLRRFSLATIPQAVNRLLQSISSKSDSLHASSALPGRRKRKSENIPLSCNKLDANETKEKSLIDEATLRFRNVKMETAYHSQADQWFIPALAISIFYLVIYAVYHVLVLPRQIATLIMIVMTLAVMFIILLMIYIDYFENFCQFITRTLFGQSIGTLLILTMLFICGIVNTYSCPQNGGSKVDLTSECFVVHFSLYNCVFWMLTTVAFVRFSSFILFLSLIVAFILYSFHVFITHPELYYSYSQYTQSSSVELELLNGLLVFAFLIFLQARRNERILRFDFMSKLKEVEEKSELERTEALNQKMLQNILPHHIAQSFFAKSELYYHLCHSGGVIYISIVLDDKDIDSNMSSLRNIVSTIDQVLAKYSGIEKIKNCQKFYIAAVGIIPETCSNVHDTPSTIGDLLNELTQFALTISAIAASQGIGLNIGIECGSLLSAVISAHNPVYEIVGKACERARTLMEHADCYGIMVSEEIYLALRPRNFNFDSRPIKIDMAITAYVFEESYPVEESDAQSAIDAAEHSQSLNPLGMFASMNSSFTSEAYSLDIGVEVESDMEWITPEMILSDHRGEYPSTSGIGMSQYIPSSSNPRSEGSLSPERLRNRRMHSGRFMGLMNCSTISDTGQSCNGADRLAAAAFRVDRMLEELNAVAELSSKNDCCPFPTALSMSTRSLRREISSACHTEYDNAESEGLCSDSEILGGRLEQLKKALKQCRASSERRKRRKFWNNFDNGNDADIDSICSSLNVSSIFGNFRWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJW9</accession>
    <name>A0A0N4UJW9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2108</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJW9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJW9"/>
    <dbReference type="WBParaSite" id="DME_0000798301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000798301-mRNA-1"/>
        <property type="gene ID" value="DME_0000798301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1320.10:FF:000004">
        <property type="entry name" value="28S ribosomal protein S16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000798301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13399" checksum="9E1EAD5082A6B159" modified="2015-12-09" version="1">MRFAKSIGRPSIGFVLAGCRNRPFYLICVLPDRTLGRHYRGSAIEQVGCFDPLPNFRNEKLVALDIGRLKYWIGVRNANISVSVLELLGKLVGLSGLLPIHPKTYIRSQAYRKAALEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK08</accession>
    <name>A0A0N4UK08_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS2152</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK08"/>
    <dbReference type="STRING" id="318479.A0A0N4UK08"/>
    <dbReference type="WBParaSite" id="DME_0000802701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000802701-mRNA-1"/>
        <property type="gene ID" value="DME_0000802701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="352"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN52179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000802701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="78259" checksum="0011EFA24A5D4D20" modified="2015-12-09" version="1">MQNDEASKNVYNFASGGGSSTKNFVIPERLRKRKTKISLPVKKRVIKEDKVIYKKRRLSENSELSELENSDRSPIKTRGIKKKGCPRTQYESLPDHLTCLGYIEESASLIYKTRYLDWICPSCLVCSFCGEFIADPENVQCFNCDRAFHGICRPKNGKWANSKNPVGHWCCDLCNIGSIKSNFFKSLCDKIKSDATRQTEKNVSKYYRYVSSIPFSTNKDVQNGRNEINNRLKDLYKAKLAEEEKRGREDKLLRSNIENFKPKRQSKFLPGSHKKHTKVRNFVSCSQPIKEAELKISIKEKQKSFESIYKRMKEISTDFDYDLQPSLLSRFYRFMEAKEEAEKDERKRENGSEENRTQCVHFGNHRVLAQYVSAYPRNLASAQNLYICRFCLLAFENIVKYEIHVQYCEWRHPPGNEIYRKDGLSFWELDGDIEMSDHLNITIGRGYCRRLCLFSKLFLSSKTLHHEVETFLFYLLTENTPEGCVLLGYFSKEKNPGKNNNLSCLLTLPFSQRDGYGKFLIDLSYKLSLRERKIGGPEHPLSDLGLLTYRSYWKNTIFSYLRRKRYQASISIKDLSHESGIHPSDLIGTLLENNMLKIRNGLHMINLTCMAQLAQLVKYLSDLHAFAFYIKMKKAVNAPLHTFRRRVVDDEKLIWEPEFDVEDSQKMGTYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK96</accession>
    <name>A0A0N4UK96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10266</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK96"/>
    <dbReference type="WBParaSite" id="DME_0000813001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000813001-mRNA-1"/>
        <property type="gene ID" value="DME_0000813001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868199at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040468" evidence="2">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000813001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17637" checksum="20149251362BB386" modified="2015-12-09" version="1">MKYILVIFFSLVQRAESGLSANLDKCVNPASPAAMPRPLPPPTACKNKDPTICTAVFDPIGLTSVALEKCPKPCGLCNVPGAAGRCPDVSDNCISLLPILTCNNTYMQQNCMLTCRITTCISTTAAGSSACSDSRANCGQLANYCTIPPYSTVMRDQCKRTCGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKH0</accession>
    <name>A0A0N4UKH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2286</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKH0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKH0"/>
    <dbReference type="WBParaSite" id="DME_0000821001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000821001-mRNA-1"/>
        <property type="gene ID" value="DME_0000821001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF78">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="3">
        <location>
            <begin position="551"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="950"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000821001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1237" mass="138252" checksum="01CB5A937D3E6AF5" modified="2015-12-09" version="1">MASSNQRGKTRKNGPMQGDFGGQSVVGNQATILPPPMAHIIANGSARQQSAPLGYPADNGHMVAQPYNQPRLNNPVMQYAAGEVQIETPSQGNPQLTTIHHRFTQQNQNFHTSSTQVNNYASATPIAYHQSHIYGSNLFSVPYMQAYPTPYFTQIMQNQYNPNFMSSQQADFLTQRYTQQQVHMVNPAPATTAHIQKEKKILRIIDPETKVVTNEKEITASKSAQSTNEQLRKSDSDNRDSKPGITPLPAKEIGSQQSSNVSQQFSLKVAQSILGESAAPSSLSASVPPPSVSEQTVLAIPRPSVSAPPVNSLSTVSQKKVSQSSSAGQLEKIKQNKGVSTSTKDDVIPGKDAIINKLADSFAEMAFDENPNKEELEKDSELIEPPSAAGRAVEIVLEETEKEEEENEKKASTKVQNELLQKITEVRESDISIQKKIYGRYFLLLIRDLFKIAKHDHSPISKTELEALGIDIGSAPAIPSERQRRYDGSSAMATRGFIPGWAADKNSNKAKPSGPVSRPSIDRTREPVELHKAENAWKRGVDAGNPLQKKLKVIRELLNKITPSTFNILSQEFLSHRVTDDSDFMDGVIGIIFEKAVEEPKFCPLYSDLCKIQVSEEAKDRFDENGEIIKGSAGFRSGILSRCQSTFESKRENEVATRKIAIEEEPDEVKRKELMLEFLENEAKERRRMFGNITFMGQLFRHDLIVPRILNWCIIHLLKNHTESENGDEESVECAIRMIETVGPKADRLLAEKRLAEALNSSTSGETQKNDENLFDSSLYIDFLCNQQNQFSNRLRFLTMNLIETRKNKWTPRRTAEGPKTIEEVHDDARREELLNKYQREQYEKKRYDGRSSSDKRNQIQKPMIISRQSQDGRYINKGSDSSRDQKARAAGAANLVTSTISRKNQSLNSVGLQDVDQPQSFCARRPHFSCGSGGGGQQADRTNVQARGLAGGLRGAGRGVIPTRENSRPRSRESSETRKSSRNDERISVFPIAQNKDSQRFGGYANSVAGGSAEEERQTCGNTNENNEANEKRGFQVLHADLLECFKNILSIEEAFNSVNDACTSYSPRKAFKWIMQIAVEKISGVGHQRRTGQVICRSLQKSDIKKDALLGIADFCKYAVDNELWYECGKLWEMVAEIICWSIMCDIEQFGGARASLRDFELAFKNANRDSRVPDALLISVLKRLAEIEYEKDKQVCSLGMAFEEIKELHSESLIEALKSCKLSFGGKNLFELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULE2</accession>
    <name>A0A0N4ULE2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2529</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000065">
        <property type="protein sequence ID" value="VDN52556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULE2"/>
    <dbReference type="WBParaSite" id="DME_0000861401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000861401-mRNA-1"/>
        <property type="gene ID" value="DME_0000861401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5828229at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000861401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13753" checksum="7E458B572D562422" modified="2015-12-09" version="1">MNLRIASNRFKQSIFQIAQDSDWHNWHTSSYSFSQHHDLELENAEQTSINDNFKDLEGRISKEALNIIRRLHQENPKNSFFQPFRINHFNNYPPSQQSSSTDSKEYVRISGRLDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMQ9</accession>
    <name>A0A0N4UMQ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2886</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000087">
        <property type="protein sequence ID" value="VDN52913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMQ9"/>
    <dbReference type="WBParaSite" id="DME_0000914901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000914901-mRNA-1"/>
        <property type="gene ID" value="DME_0000914901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000914901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21935" checksum="40DE6E93FBE5C041" modified="2015-12-09" version="1">MQKDCSDSCEEVLNEISRQIVDSILKNDLIHEKETNVLTKMEDSGELIDLKKSKIDNSTAVVENGTIVVSITNGDKTDVKVYEMQDGNSKIKEDKNGNRLNQSNQEIDEADNEKISDLLVKDSNSNKINDKDNKKPESANDSDKEGKGSNKIVHTGGGDIDDLVGETFHKVITTMLTDVCLFSHFSNFIDGGFKVHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMZ1</accession>
    <name>A0A0N4UMZ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger CCCH domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2988</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMZ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UMZ1"/>
    <dbReference type="WBParaSite" id="DME_0000925101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000925101-mRNA-1"/>
        <property type="gene ID" value="DME_0000925101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000925101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35256" checksum="653A341BA1DD35A5" modified="2016-06-08" version="2">MTEKDAKHEISFDKKKNGNEREDVCRDFLKNICNRGSRCKFYHPENIEIARRKGLAEPEYNFCIDFQNRGCQRDNCRFIHAHRDDVEHYKMTGDVTLNLARAIAAVHNGDTINGIPYCKEYQTGSCSRGIPRCRYWHINIEEERERRRRTRSFSAVTNSSRVPALPYGYGSSAITRRPLEYTERDLYDGSVTKRARYDCDQREYLHDLERRNAELIKENEGLKRQLQREHDRYQDLYALFRQRTTPTSVSAPVAPPTPAGDPTAPAAYNAATYAASNIANAASGVTYYPSNPPSWTNPSTRSQWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN03</accession>
    <name>A0A0N4UN03_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS3000</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000095">
        <property type="protein sequence ID" value="VDN53027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN03"/>
    <dbReference type="STRING" id="318479.A0A0N4UN03"/>
    <dbReference type="WBParaSite" id="DME_0000926301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000926301-mRNA-1"/>
        <property type="gene ID" value="DME_0000926301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035095">
        <property type="term" value="P:behavioral response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14089">
        <property type="entry name" value="STKc_MAPKAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1170.10:FF:000001">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN53027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000926301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39206" checksum="4C6EF62FB61BF105" modified="2015-12-09" version="1">MPVHTHSVTIDYRISRQVLGVGINGKVVECESRKTGEKFALKVLRDVPKARREVELHYFACQHKHIVRIFDVYENTYNQVKCLLVVMECMRGGELFTRIQQRAQTAFTEREAAQIMNDICSAVAHLHSLNVAHRDIKPENLLYSCDGPSGILKLTDFGFAKKLETTDTRPLETPCYTPYYAAPEVLGPEKYDMSCDMWSIGVVMYILLCGFPPFFSANGLPMSPGMKNRIRSGKYAFPSPEWDRVSEAAKDLIRKLLKTDPAERYAIQEVMSHKWIIHYQKVPETPLFTASVLKEEQSQWGEMQDEMEKTLATMRVGNGDIHIKSLKDSNNRLLNKRRNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN75</accession>
    <name>A0A0N4UN75_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3065</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="UYYG01000101">
        <property type="protein sequence ID" value="VDN53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN75"/>
    <dbReference type="STRING" id="318479.A0A0N4UN75"/>
    <dbReference type="WBParaSite" id="DME_0000934301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000934301-mRNA-1"/>
        <property type="gene ID" value="DME_0000934301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000934301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27044" checksum="0B82FD1749229184" modified="2015-12-09" version="1">MMSHFQLLNENKCAPPVAVFFTCMDARIDPLNLTHTQAGDMYIVRNAGNMVPNSLTFGLCGQEILAETEPAALDLTLNRSKIKHAVVCGHSDCKAMKLLRNIYENPHEFDLSSPLHQWVRKRGYRSVDKLQERLKKGNSKIVFASNDNVFSFRALIDPENTLNIVDILSQINTLQQVENITSHGFLKDLIAKNQIHLHALWLDITNADIYLFSKKHERFIIIDEKTVNDLLKEVMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNK1</accession>
    <name>A0A0N4UNK1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3170</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000111">
        <property type="protein sequence ID" value="VDN53197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNK1"/>
    <dbReference type="STRING" id="318479.A0A0N4UNK1"/>
    <dbReference type="WBParaSite" id="DME_0000948401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000948401-mRNA-1"/>
        <property type="gene ID" value="DME_0000948401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000948401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25757" checksum="2AB82E730F9F6E2B" modified="2015-12-09" version="1">CIIHRYKIAVVGAKGCGKTAFARRLARDIFYEADNALQNNSPPFRQFFHCEQSDGNRIKIELIDVSVEQLDEHVRTANTIRQRLVVGEPISVKCTEFVDLCGIFLLYDTTDSKSFDGLHNIIGDLSHLTSPGCEIFLIGCKSDLREQRKISFKEAEDFAIRIGFSLFETSSKSGLNCTNALMEMVDKIYEKQEEAACYICDSVEEEETASVQRFNIPNIFCNLWNCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP16</accession>
    <name>A0A0N4UP16_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3312</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000122">
        <property type="protein sequence ID" value="VDN53339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP16"/>
    <dbReference type="STRING" id="318479.A0A0N4UP16"/>
    <dbReference type="WBParaSite" id="DME_0000968301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000968301-mRNA-1"/>
        <property type="gene ID" value="DME_0000968301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000068">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="456"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7 8">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000968301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="790" mass="91654" checksum="2041D4AF6E7ED8B6" modified="2015-12-09" version="1">MANQNVNNEEHLKLFPLTITVISAKLHGVRGLFSKPPDVYIELVVDSSLSVKTTIKKKTSTPIWDEEFLVQVNEMSVIDFRIFARSKLFEDSLIGQKCLKMSHALKKESDNGKFDMTKITLHVNSSKDNSKSGELKISLNGVIERQKKRSAGSNRGLEGYGGEASTSNNINITNGSIAGSSNGTALTNTCRRNNSNKTRDTMLSQTGTSSSSNTSEEPLPEGWELRYDAFGRKYYVDHTTKSTTWERPSTTPLPSGWEMRRDPRGRVYYVDHNTRTTTWQRPTADMLQARDLWQSNRDQAMHQWEQRYLLQSNAMIANDDPLGPLPNGWEKRADPSTGRIYFVNHVNRTTQWEDPRTQGISDEPLPEGWEIRFTEQGVPFFIDHNTKSTTYNDPRTGKPVGPMAVQGMMSFERTFRWKIAQFRYLCLSNSVPNHVKIIVSRSNLFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGANNYSLQINPASFINPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKLTLKDLESIDAEFYNSLMWIKENNIDECDMELYFVADYELLGEIRTHELKDDGADLKVCEENKDEYLELLMEWRFNRGIEQQTRAFFNGFNSVFPLEWLLYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQIVWFWQFVRSLDQEKRARLLQFVTGTCRVPVGGFSELIGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYEQLAEKLTRAIDETEGFGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPF0</accession>
    <name>A0A0N4UPF0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3416</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000132">
        <property type="protein sequence ID" value="VDN53443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPF0"/>
    <dbReference type="STRING" id="318479.A0A0N4UPF0"/>
    <dbReference type="WBParaSite" id="DME_0000983301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000983301-mRNA-1"/>
        <property type="gene ID" value="DME_0000983301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000983301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45474" checksum="563F48B49BC81E36" modified="2015-12-09" version="1">MASPRTRRLIRDLRMINGNNCCFECGASNPQWASVTYGIWLCLDCSGLHRGLGVHVSFVRSVTMDKWKENELNKMKVGGNKVAKQFFESQPDYRPDWSLQEKYNSRAAALLRDKILTKSENREWSVETSSAKNYSPSFLGGNGSSIRTGSSNSLSTFYGGNLRPGTNVENYNDDNRYSEMNNRYQGFGNVIEKNSNQSTELLSGAVSSLSMGWNIISKGAVNAAGYAKDFGVQATAKASELGGTFSEKIRDVPLLNNANLGNIASKATEIGSRSWNGLSSFVKSPSLPGFGLPFGKTDYEDLASPTSQEGLSIGSTVYQGYDSQSYIEGSFVAADNSFLTAGNQSEESVKPMSSKKISKAKADKKDLKSPLIDLDIDNSSTSNEDTAYNKASKTNTVAAKCKKRDWDDDAWDLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPU7</accession>
    <name>A0A0N4UPU7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3542</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000147">
        <property type="protein sequence ID" value="VDN53569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPU7"/>
    <dbReference type="STRING" id="318479.A0A0N4UPU7"/>
    <dbReference type="WBParaSite" id="DME_0001000201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001000201-mRNA-1"/>
        <property type="gene ID" value="DME_0001000201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000209">
        <property type="entry name" value="Synaptotagmin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF360">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="172"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001000201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39836" checksum="92FAF67DB6D1B637" modified="2015-12-09" version="1">KFQYLYLKTSVPEFFNRLFNLFFLSLLQEIDKRSVQRYESCSVQKQELGCFRGTLTFALRYDFIHRVLMVHVNNKLLEPYIKMYLLPERRNHCKTRICKKTTEPEFNEMFSFDVAFINLQNRMLQFTVYAFDRFTRHDLIGNVILRDLFDKSDLTAWTEYVMQIVGNQGKNDYGDLLLYLSYSNKLQKLYVNVSKAYNLRPMDITGASDPYVKLAQVYSNKRVKAKKTSIKRANLNPVYHENFEFDLPVSSINDTNMLIQVMDWDRIGRNDLLGCCIIGPSSPTAEGRQHWAECFQNREFDDFDTSKSKGIGRWHTLLAEVPENFRNIRKKETNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ72</accession>
    <name>A0A0N4UQ72_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Intraflagellar transport protein 52-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10840</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001256">
        <property type="protein sequence ID" value="VDN60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ72"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ72"/>
    <dbReference type="WBParaSite" id="DME_0001014501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001014501-mRNA-1"/>
        <property type="gene ID" value="DME_0001014501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259368at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="76"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="312"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="406"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001014501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58972" checksum="C647F5C0C573D6BF" modified="2015-12-09" version="1">MVDYSLSMPLHRENLLKILPNSFRNNDDLSEQSFFECRIFIIPHPKAKFTEEEATIQRGKFILSIFWKPTLTLKVKFQFELIRKYLNKGGSVLILMSEGGETEANTNINFLLEEFGISCNDDVVIRTAYWKFFDPKEAIISNGILNRAIPLATGKQFSNYEAENNAQALCFVYPFGCTLNVSRHSVAVLSSGSVCVPVSRPICAFHKLPNIGGKLVVIGSIHMFTDQYIDKEENSKIWVIKSKYSILDLSKLGNGIEGLPLQSVLIAVVLNNDEYLQEVVIKYLMGEVELNHIDSSEPDLIDAHPIPDHINISDQIKVCLQEGDFEIARSGDFLKLFDLSLYSMDLSLWAKSIEAYSQLELKYEQLSLITPHFEIPLPPLQPAIFPPNFRELHPPKLELFDLDDVFSSVDIRLAQLCNKCEDTDLEFFIMEACNLFDIARNLPKDDRCAKRVLEYVLHQVVEFKKLNQEDYDVDNSAIDADIESLNADADDQVVNLVNMYDNEHYSYESEDYDDMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ75</accession>
    <name>A0A0N4UQ75_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10843</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001256">
        <property type="protein sequence ID" value="VDN60870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ75"/>
    <dbReference type="WBParaSite" id="DME_0001014801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001014801-mRNA-1"/>
        <property type="gene ID" value="DME_0001014801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001014801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9255" checksum="60754471FB77D9B0" modified="2015-12-09" version="1">MGHSIYASILSADDHDKDKFYAELQLLTSLSKNDMDIIEGDWNVCFDHDAATTNSMIEKIRYRGQMRQWRTPSLLCRALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQF6</accession>
    <name>A0A0N4UQF6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_S9_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3743</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000177">
        <property type="protein sequence ID" value="VDN53770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQF6"/>
    <dbReference type="STRING" id="318479.A0A0N4UQF6"/>
    <dbReference type="WBParaSite" id="DME_0001024201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001024201-mRNA-1"/>
        <property type="gene ID" value="DME_0001024201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001024201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17686" checksum="710F32A22BE41582" modified="2015-12-09" version="1">MQQLSVIKECVVSPYYKIISTSSTALANLDSQLVTYSSDNKKMVSLIMVNDNMEKKQYIRVFNRIENLELCCVDVTTPKMHGVIHEKSPFGGFKWSSNGDKILYVAEKEEKATEFFDASLDWNDANKIQESHIVHFVFSFHFIFSKLFGRNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR29</accession>
    <name>A0A0N4UR29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3946</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000228">
        <property type="protein sequence ID" value="VDN53973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR29"/>
    <dbReference type="STRING" id="318479.A0A0N4UR29"/>
    <dbReference type="WBParaSite" id="DME_0001049701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001049701-mRNA-1"/>
        <property type="gene ID" value="DME_0001049701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF184">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001049701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21336" checksum="6F142447B4AA11D0" modified="2015-12-09" version="1">MSRKFITATLTARDHVLQSIFSNSFLSRSRKSTKAERRARKAFRTITFIVGFFAILWSPYYIMATIYGFCKGHCIPGILYNLTYYMCYLNSSGNPFAYALANRQFRLAFLKMFHSVFNKDKEPFQATIYGFCKGHCIPGILYNLTYYMCYLNSSGNPFAYALANRQFRLAFLKMFHSVFNKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR64</accession>
    <name>A0A0N4UR64_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3970</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000234">
        <property type="protein sequence ID" value="VDN53997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR64"/>
    <dbReference type="STRING" id="318479.A0A0N4UR64"/>
    <dbReference type="WBParaSite" id="DME_0001053601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001053601-mRNA-1"/>
        <property type="gene ID" value="DME_0001053601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR DMSR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001053601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16400" checksum="FB39994CD3864E8F" modified="2015-12-09" version="1">MMNALEQCQTVIFQLPEKSIVYAWLYNIHSFYRPIHTYLSIFLCAVGTLCNFCNIVVLTRKQMRTPVNMILTAMACCDTVVLFSNLIYTTHYTFVAFANCHPKHWSYGWAMFLISHANLSLVGHSSSVWLSGNTYIVEIFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URE4</accession>
    <name>A0A0N4URE4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4044</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000259">
        <property type="protein sequence ID" value="VDN54071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URE4"/>
    <dbReference type="WBParaSite" id="DME_0001062101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062101-mRNA-1"/>
        <property type="gene ID" value="DME_0001062101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47414" checksum="B7E56AAB2D71DAE7" modified="2015-12-09" version="1">MVDKSSKATNEKEKNAKFLGNQFWTQSKKSVNYNSGDQQIRPESTVSRQFLPKKQQRINEAWNKQAQEKTDELNQPFNYTPFKSGSLNKAPSTSAFRRGTPNPPDILQPNILIPPGNLQPTDFLLKRSETPRAQVNPYQIYGGLSNMKEICPQGQSTPKMSCHNLHGQQNHLQLSAGGYLASVHSNKNAIPRLEVKNAWKNTNLETIPLNGPYRPASAMNPLAITRPISRATSDIGIGMMNSGFESRYQSYTTLPRPEKLDYDQRSNHGSEVIHLNKQMSMIYNPYITKPSTDTQISNRPPSSILIGAPGMVSDYIVRKPSLYTGDPIMPPITVQDDIIKPAVDIVYFDGLSLLSVFQVSRSFINQNAKKNENTLFQVLCALVTITCGVLRLLWRAKYAIGIEILFSVLVLIAGIMGIYANNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URN8</accession>
    <name>A0A0N4URN8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4126</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000313">
        <property type="protein sequence ID" value="VDN54153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URN8"/>
    <dbReference type="WBParaSite" id="DME_0001072001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001072001-mRNA-1"/>
        <property type="gene ID" value="DME_0001072001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001072001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14952" checksum="02E9178839E7FF8C" modified="2015-12-09" version="1">MDCFLKRFWDYCGATLGWQRRRLGYWCRAEFVAIVVIGEGLGHYLSNNGGLPTLFSSVRMLGRFPKNIEYQGRRMFVLRRHFAASTYKRQRLLQEYKRDIAPHLWAALLNISYDMIRQFEFVDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URU1</accession>
    <name>A0A0N4URU1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4176</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000360">
        <property type="protein sequence ID" value="VDN54203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URU1"/>
    <dbReference type="WBParaSite" id="DME_0001077301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001077301-mRNA-1"/>
        <property type="gene ID" value="DME_0001077301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040021" evidence="1">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001077301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17131" checksum="59DDBA564B6DB0AF" modified="2015-12-09" version="1">MFVSLLILASLCNLANGEAVNIDVCNVPVPVMAAIVQRPSVPVENCQDRDVPACYEIFRHDDDPGQFGMILMNNRMENMNYQVRDKCQQPIYKMLARQMCPRTCATCCLTKEYNCENATTLSSPTQNCKDERQGCEAIRASNSCGGVFRTTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URU3</accession>
    <name>A0A0N4URU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4177</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000361">
        <property type="protein sequence ID" value="VDN54204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URU3"/>
    <dbReference type="WBParaSite" id="DME_0001077501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001077501-mRNA-1"/>
        <property type="gene ID" value="DME_0001077501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001077501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12492" checksum="3F460A26EAB98F84" modified="2015-12-09" version="1">MLWNIQAKCQKPNLVRLGEQMCPRTCAACCKSRKFNFSVGQCDSFTQAMCRIPSLNKIALEICPHTCGLCDLPGADTIDGCESLRGFCHFDSIRNICQRTCLSRACFQNFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URU7</accession>
    <name>A0A0N4URU7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10958</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001302">
        <property type="protein sequence ID" value="VDN60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URU7"/>
    <dbReference type="WBParaSite" id="DME_0001077901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001077901-mRNA-1"/>
        <property type="gene ID" value="DME_0001077901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720554" evidence="2">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001077901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22534" checksum="62E5BCBF732B87DC" modified="2015-12-09" version="1">MFIALLIIASLCTLSNGATETINVCNVPMPGMAQMPVQRPSVPVENCQDRDALACYELFKPGDNDGEIGMAFNQNRMENMDYKVRDTCQQPPYRMLARQLCPRMCATCCLTREYNCDKELQAYILAWILATTLSSPIQNCKDERQGCAAIRASNNCGGVFRTTMMQQCARTCGYCTMEAKSSSRELSNMFHDRVMLLEPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US30</accession>
    <name>A0A0N4US30_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4256</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000502">
        <property type="protein sequence ID" value="VDN54283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US30"/>
    <dbReference type="WBParaSite" id="DME_0001086201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001086201-mRNA-1"/>
        <property type="gene ID" value="DME_0001086201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001086201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12097" checksum="29C0D4E7F5B7365B" modified="2015-12-09" version="1">MAHCRNPILYKILLAKCPAKCGLCDKPGALGKCPDAHDSCPVIARFPDACNNERIQKILADSTSTIAVTRPACADQRTNCEKYAPFCRHERYSAVLSTICPRTCGLCVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2X2</accession>
    <name>A0A158Q2X2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein-like 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5387</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2X2"/>
    <dbReference type="STRING" id="318479.A0A158Q2X2"/>
    <dbReference type="WBParaSite" id="DME_0000102701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000102701-mRNA-1"/>
        <property type="gene ID" value="DME_0000102701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000493">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="116"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000102701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49874" checksum="D33BC893B84A9D92" modified="2016-06-08" version="1">MVILIHKAIAINFKRKKKSKREKPIHVPNKCPFKEEVLLEAERARENMEKIKEEKKRLAKQRRFGEKNKLFLPNSIEDFANNATQRDINFSQKNSSEIEENKKLKNITDKQINMYANEVRKTIESADIVIEVLDARDPLGSRNQNVEHIVVSSGKRLVLLLNKIDLVPKDNVYKWLKYLRTQFPTIAFKASTQEQSHNLGRFSFSTLRANRSKCFGAEIVMNLLGNYCRNKNTKMSVRVAVVGYPNVGKSSVINSLKRKRVCDVGAIPGITKQSQEVELDKHIHLLDSPGVILANKNELDNVEYALKNAIRIDNLSDPITPVQAILRRCSKDMLMLHYSIANFENVDDFLAQIARKIGRLKKGARPDINAAAKRVLYDWNNGKLRYYTEPPEAESEQTINASVILNEFSSEFDLDSLKLDEEKLFSVSIMVAFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q321</accession>
    <name>A0A158Q321_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS5833</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q321"/>
    <dbReference type="STRING" id="318479.A0A158Q321"/>
    <dbReference type="WBParaSite" id="DME_0000147301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000147301-mRNA-1"/>
        <property type="gene ID" value="DME_0000147301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF271">
        <property type="entry name" value="FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN TAG-77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="338"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="578"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="753"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN55860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000147301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="954" mass="109245" checksum="490746FB79A6AC0A" modified="2016-06-08" version="1">MRKLNERTSTATATASVKEIRERLERSAAAQSLGINKCFNDNYLEASGNNSEDHTDSLCIDQKQSILRKINRPPIAPKPLNIKSTSHEIPSQIPNTIIQNDIGFAAYELDSACCSNIPCASTENSSSCSNQKTDRKTDIYEPNDGRSMNVKDVVARFDKVILNNFVVRSNQFRFSAGQLTVPSLDEQRISSVDSWSDQKNASDSDTDTISLEEFVELPLNRRVSELGDEVLNQSVFKKGVSFWKSTSALQNESFLPSDIGQIRNHSAKQNRSAISDPLNSKDSKNKINLRHHSENDERLSNASAISGMSMMTMNLSDSQYDYINYWDANPEEEKRLKKLHYAAKEIYTVEMKFVAQLEIIAEEYPKFLIHYGEQLGVDLLPTQSSGQPHIIRQIAIQLSMIKEAHKVLLEKFAAKMSIWNSRSPDMAECLKNGAPFLKYCLPYLKEKKRFVDELLKQLQENELLSKATTKFEELCSSKISVVQQLDIVHQNVVRYNILLDAYKKYLPADSREKLECEDAIVELSKISELVNHQISLAEMEKRLINIYRRLEVKYSVINSLLTYRILKGKFNVFEANRHLLHEGELMKQSRKDLQPRYLILFSDVLLICKYPRTPNLVSEIFQPDFYRFNIARIRVKAEEHGEYETHFQLLTTEKSAVFIAKTKRERDEWVKRLNQAKTEAKKLRKMNRYAKLSDVRIFHKGDKLVGKKNIEPRTAEKDTSDNETSPTYVPVKEKYMALWIPDPKATSCMMSGCTTKFNVFNRRHHCRECGWLICHSCVGYAPVKNGSNFIKGKVCPECFTKIDGTWEGDRSSGLFLPPPGGYREKTIIRGRDEDGTVSGTVYIRNKRLGEIEKWGRLIRHDDGATVLYFFDAEFDSKPFARHVLLGFELTVNELEEGGRLFELHHHNQMLGQSLSIVFRVAHSGNAEKWNRALIEGVKAFESFNLNCDQSNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3N1</accession>
    <name>A0A158Q3N1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like and fibronectin type-III domain-containing protein C25G4.10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7112</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3N1"/>
    <dbReference type="STRING" id="318479.A0A158Q3N1"/>
    <dbReference type="WBParaSite" id="DME_0000275201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000275201-mRNA-1"/>
        <property type="gene ID" value="DME_0000275201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="575"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="817"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000275201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1487" mass="166690" checksum="4F57DECCE2F2EFE4" modified="2016-06-08" version="1">MDSSSPAVEWWDIYIYCIHRLFTNKTCNVVILKSLTFSLFLSRKISAMFLFICMFLLFSSSYIQCLELHLTTSDEGYVTVIQGFAARLECTLSTCVRHAATVVWFKDDIPLFNATNFLASSGVDPNTVLLQHRVEYDREKDCASSCSDSKLCEDGSHCLDNRCCPCTSEEFTLVLKNLTFDDAESGLKGGFHENISYDYSECCEKKGISPLCKAMCKPKDMHIHYFDPTSCKTDDYKNFLSCATEGGNRSHVQCCKTQLVPSFCYDFCSGNFQMLRKSHRLCLYYLPEIFECYNRAYLPYPDHPLDLIVNAIGSDELKVCWQPPQPHGMPLLSGDYEEPNVGTDEEFADSTTLAPISVKLRRKRQTWLFVTHDSTTNDSTVREFKFEEVNTTETCLTLKDLRSATRYIVYVTASNKFGMSVPSTRALATTNAIASSSNTSLPEIERISSILDRFNTNKKKKNRLETRICAKFSDCCTKNGASPYCVSKMCNIKSMPNALETIAISTSCRSEWSKVSPCLADGRNHTDCCIRKGVQHDCLKICGGLPEALSVHSLLCLNLDIPAIYQCLRQGYETRPSPPVNVTVNVFDDSVEIEWQEPESNAHLVESFSLFLVKNSRGAEIIEIHNVTSPHTEYGLDPDSEYTVYLQSHSSAGDSLYSTSQIFFTNPYDSAICKTGKPLYDPNGHKYNCVPGIRECPISYECIVAKNSDVDTYCCPKSVNEESTVEECCRSRGISQNCLKHCYYNSSLTEECSEFSDFWVQCASDGHDHSKCCIEFDLPSDCMDACRHPFVLKKECISHAPLLSKCYFARYLSIPKVVSNLEVVSRNISSVLLSWDLSSDASVQQYEVQLFKQGSLYKKANTSTNSYQFDNLESGTNYTAHIISYSKSASSPPSLSIAFQTLTDNANILVPTTPVSSWTTVTTNDKWYVMEDLFLDKLYEVYVVASDGRVTSRSSSVITILAAPDELSLPEPVIIIDPNYTNRTYFIGQQIGLKCSVNSRNALNLDLIVGTKMYHNNPPSMTIETSITIDEKVNGITCIVMDTDGRQNRAYAHIFVQFGPEVTMPVQQINAYDDLSAEIHCTIKAYPEPNVIWTYRQSQNSLSMQTINGPVFMKKLSNNEYDFVLFIKNVTGRNGFYSCRSKGFGDVIVSKEAELVVSKADLPLSPRFVLQCCVDAQISDNCLKACSVNPEFIDDDCSVHSNALIECAKDGRDHRRCCMDFNIPSECLGLCSSNSKIDLPHCSMFAAKAVACMIRGHESAPPAPGPIHYENLSHRSIKVYSLNPFFLLFLHKTHYASSKVVTSGIKAEEFKAVYRIHWNEAEPGSYKVYAVYYRPENSDDDFIVKKTTDNEMIIDDLEPNTNYDLALLNISEYSRSRSSLVLPLCFILIVLLIAIVGILYTSRIITLPQMFRRWQRSPLTDRDPSVAFENPGYGTEVQIRGLSSHSAGGGGGAGEIDWQNAELEIANNAISRESTNNGMRYAKLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q498</accession>
    <name>A0A158Q498_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MRG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8207</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q498"/>
    <dbReference type="STRING" id="318479.A0A158Q498"/>
    <dbReference type="WBParaSite" id="DME_0000432401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000432401-mRNA-1"/>
        <property type="gene ID" value="DME_0000432401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="9">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="8">
        <location>
            <begin position="274"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000432401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54464" checksum="076CB4E82D43B09E" modified="2016-06-08" version="1">MFETTDGTSWINLNKKSCFRAVTLDRDHILLTSLGIVLYSDFIASILLIACHWATSIMKSCQEDHRVTDMVSSLDSNNPGKESGIDDGHRNTPSARHSSIMEFASTTVIPYKVNTNILCRHVDNLFYHAKIVAVDKAPDGEYVYTVHFQGWSKRHDEKISHSSSLALFRNPAEENIQVAETKKEMRQGRALKSLKPEKAQSDRSESILSSRQSTPSSMSSHDQSVVDKGCVCDLFQSKAAPKQKPLWTSSFAVKKEQTDAALAEIELLHSSVHSEVLETILENDRRIIEHGISLPRLPARWNVSNILKQFSTYVRDLDAKILINDQMKSSKFLLWKSVVYSLDELVITFQDFFDFIISEHLLYDIEIVRHKEMAEGPARMLSPLQLSLTDYICDFRSGLRASEYYGFIHLLRTAVKFQSFVRCDEFSSDSLEMFGRILMGYLEKEVSRFFNAETDYEKVCADYQMRFTKLKERIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4A2</accession>
    <name>A0A158Q4A2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8238</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4A2"/>
    <dbReference type="WBParaSite" id="DME_0000435501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000435501-mRNA-1"/>
        <property type="gene ID" value="DME_0000435501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794490at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="45"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000435501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35186" checksum="6CCB5370F95C1AF6" modified="2016-06-08" version="1">MKYKLQAKKNRSLLTLAFSFHRGIDSGNGGFENGRQKPFITSRLLKFQKISSRLHSEIVIEPAIQHFLAIICDVKINPEQRTRLGLRYIKTSQVQGLLKRLTKQQYISNELWKIDLNTIVTALKEILSSFPGGIFADSTEEFVSISPECSLQTALIYVNGLIEALPHLLRQFAYLICRSLKNLINQSAGKSLDAYTDALLLFTPILFPHSVNDIKRFLRAIRVTLILIDYYDYVFRPFIFFSSLSYLNDDDFFGEVDSSLSNLHGSFEADDYEGIDSNEDIDFDFSFSTDKFSANNKNYYQIAYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4C6</accession>
    <name>A0A158Q4C6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8458</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4C6"/>
    <dbReference type="STRING" id="318479.A0A158Q4C6"/>
    <dbReference type="WBParaSite" id="DME_0000457501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000457501-mRNA-1"/>
        <property type="gene ID" value="DME_0000457501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12425">
        <property type="entry name" value="RRM4_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000341">
        <property type="entry name" value="Hephaestus, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250234" evidence="2">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="190"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000457501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29343" checksum="27411767DE3E8EB2" modified="2016-06-08" version="1">MTFSLTKLYLIFIPVGFADALGAPSGISPFLTGLTTTLASNAASPVTANALLNSTAAALRLPHVGVLNMSPVVLVSNLDENVRVYGDVQRVKILFNKKDNALIQYAEAQQAHLGTLKIIGITSFSAIQHLDKIQWHDRQIRVATSKHNNVQMPKEGQPDAGLTRDYSQSPLHRFKKPGSKNYLNIYPPSATLHLSNIPPNITDEFLISAFEQRGFVPKGFKFFPKDHKMALLQLSDTEAAINALIEMHNFKLADNAHLRVSFSKSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5C9</accession>
    <name>A0A158Q5C9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1585</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5C9"/>
    <dbReference type="STRING" id="318479.A0A158Q5C9"/>
    <dbReference type="WBParaSite" id="DME_0000703301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000703301-mRNA-1"/>
        <property type="gene ID" value="DME_0000703301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="897"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000703301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="934" mass="106966" checksum="976A84B421B4DEC1" modified="2016-06-08" version="1">MVSNKTKKFLLNFLFFLLFIEKIILKLLDSLLAAMSVDFGSQFLKIALVKAGVPMEIVLNKETRRKTPNFIAFKDGERLFGESALAFSVKRPQYSFTHLVDLIGKKIDNPIVKLYQKRFPFSKLTMNNAGDSLHFEVGDTKYNLETLLAMILQNAQSFTEEFAGQSVKDIVITVPPFFGQAERRALISAVNITGMNLLQLLNHHSAAGLSYGMFRRKQIQEKAETLLIYDMGASSTVASILEYRLEFDKKENEKNPVVNTLGLGYDRTLGGLELSVRLRDHFITEFKKQIKMKEDISMNARSMMKMLHEAERVKIVLSANNDHFAQIESAHEEHDFRLKVTREQFEILISDLEQRLVKPIIDALQMAEISINQIDQIVLMGASTRVPFVQAAVQKFLKEKEIGKFLNTDEAIAMGAVYQAAHHSKGFKVKKFVVKDLQIFPIQNFQVDFASNSDKSTESRIVHRSIFSYKSLYPTNNKILSFSSFKVDFPFNISYGELKHLSDEQRSEFGSMVVSNIELSGLKDAVDAELVKDGTIFKGVKTYFRMDDSGIVHIVAADLVIERGPDEKSTLSAIADKITGLFTSGRNVDDKEEKNEAISKEDQTRYEKMDSNAEDFQPNSKENMTLNATNITEEKIIKPKVIKIPLKLYERHQDFIGLSDSEIHVAKKRLTISLDDFADKERMKVEREAAYHSIESLVYDLAYKLEQSEYLIFVTEQERKAINDEVARIRIWLEDEVGVTTSTEEFIKKRRTLDNLLKPIDYRIKQEKDRPRLLSDFVSIFNHSESFLALAKNLTEIGVFTEVERSTLEKKINETKMWFIENNQAQSLLKPTDKPVYTNEDLLDKMYDLDRELKYLFNKMKITKPKKLFETVEPGSNNTSSNETVIPTDELNKQIKLDHEKSDKLKEPVEVDKSESTKVNTSEADIVRHDASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5I9</accession>
    <name>A0A158Q5I9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10088</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5I9"/>
    <dbReference type="STRING" id="318479.A0A158Q5I9"/>
    <dbReference type="WBParaSite" id="DME_0000750301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000750301-mRNA-1"/>
        <property type="gene ID" value="DME_0000750301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000750301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19140" checksum="250D5C07322022FF" modified="2016-06-08" version="1">MKTPKNEPILTYKRGSNERIALDKKLHEMADQTAHIPLCIGSEKIYNNLEKEQIMPSDHKTVLAKFTFATAEQINHAIEIAMAAKEKWEMTPLKKRADILLHAADLLSGKYRMAINAATMLGQGKSIVQAEIDGACELTDFFRFNAMFTLDADKYQLISPQGITNSMILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5X5</accession>
    <name>A0A158Q5X5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10387</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5X5"/>
    <dbReference type="STRING" id="318479.A0A158Q5X5"/>
    <dbReference type="WBParaSite" id="DME_0000852001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000852001-mRNA-1"/>
        <property type="gene ID" value="DME_0000852001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="7">
        <location>
            <begin position="363"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000852001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="79703" checksum="77DCEC15E44E6126" modified="2016-06-08" version="1">MIVDLVGDILRQKPSLSEYEHRCLIVSGIPVVGDDRFARLKNVLGKIFGKLNADYTDYYPLDNNKTKDYCFVLYPTTEIAEHAAAVLDNYLLDRNHKFRVNLFDDIHKFTKIDESWQPPAPRPFNDLGDLWSWLQSDKCYDQLAIHYEREANLKGSGVIPHVGVYEYRKGKDPILMEERQNWTETVFKWSPYGTFLTSVHRMGVVLWAGEKFNRFNRFQHENVMMVDFSPCERFLITYSPPSEKRWRDDPNSLRIFEIETGEMRRGMMLDNTQMSSWPYFQWSFDEKYFACIKPGGNGISVYETENFTLMDKKHVQVDGLRSFKWSPTRPYLAYYCEERSNDNAPAEIGIMEFPSKIKLRAQRIFSVSDAELFWNKNGDRLAAHTERYQKKIVKTSEEGDIKYIKPASYIEIFDARGKDVSVLTLPLNEPYIAFGWEPAGDRFCLLVGSQHKSTPLIYHLDPSKHVPQLLSKFESADRFSNVLWSPVGGWLVVYSASSSSGNIMFIDGNGPEPSRTNLVEYPGFDKGSWDPTGRFFSAASTISGGKGDMGYRIYTFQGRELYRKGLDRLIQFKWRPRLPIKLSDDTVKMIRKNLKSISAKFEEEDKLERGKATKEVSEKRKKIMAEFKRIVVNIQERYCSEEKLRMKLRGGFDTSRKGSPELVEETITVALSTEKIKIKELSTVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q673</accession>
    <name>A0A158Q673_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH_10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2985</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q673"/>
    <dbReference type="STRING" id="318479.A0A158Q673"/>
    <dbReference type="WBParaSite" id="DME_0000924801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000924801-mRNA-1"/>
        <property type="gene ID" value="DME_0000924801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041194">
        <property type="entry name" value="GLD-3-like_KH5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17905">
        <property type="entry name" value="KH_GLD-3_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Defective in germ line development protein 3-like KH5" evidence="1">
        <location>
            <begin position="237"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000924801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49060" checksum="AB8BF528C69109FF" modified="2016-06-08" version="1">MHTGQIISAFAFKIQICDQIGRRNELSYEQRRLWEINRLIKIGKSEQIKFIERAPVNTNVTLVIGISFIEHLSMISQAGFLNKNDSIPKIMQDTGVLIHFPDVTNAVDGIKLIGSIRNVELARLRIRAMPMCFIRGSLLYESEICDACEALCKLLFDENASSNVLFSTSMDIPSAQQLTVTGYPNNSLIKYICSKTNTLISFPVFSGGNSSAKMFYFCGSAKSVLLARKYLQGLTHVQLSFDVEHEDLRDAPLKNRNITKRNEEMDVNITITRSRLEGRRLFNRDTLRHFVTIESGEYNLNKVYATHRRLISRVDKVDVATGDYDFFDDSFKQLIAVSNSAIAKAMDPLKITDSIPFVHSRNRGVSEITSDPSDASTSVFFRYDQGMITYFPVLTQQTSLKEKNDNYRFISPPIANSINLEINATQNSLPKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6G6</accession>
    <name>A0A158Q6G6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3558</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000150">
        <property type="protein sequence ID" value="VDN53585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6G6"/>
    <dbReference type="STRING" id="318479.A0A158Q6G6"/>
    <dbReference type="WBParaSite" id="DME_0001002301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001002301-mRNA-1"/>
        <property type="gene ID" value="DME_0001002301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001002301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43339" checksum="D1EEC9C2EE1CC530" modified="2016-06-08" version="1">MICEGNERQLFDLTNEKTAEFIKTLIELSSAYTNIHKYMCLAVCAIGIIANTVHVLVLTRPNMRTSAINRLLALMASCDICTMVSYTVFNIRFGLLISAENPPFGYSLAWIWFLLMHVVVSIALHTVSLYISVVTAYIRYHAMDKIASRWLMATSAKPIFMIILLAVGFASIPTFLVHGIERVNPTLANNETLYTIGIPKIAIANHCFLFKSNLWLTGILFKVIPCILLFSFTIALMKKLNDNRKRRIFLRINSKFSKIYIPDRTTKMLTILLLIYLFTELPQGIIAILNGLFPNDIHQYIYLSVGELLDFFSLISCYACFIVYPCISTQYRETFREMLTQIKNNQRCKKLLPEKSNNFAMATVMMGDDLQYRDTDAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PED0</accession>
    <name>A0A3P7PED0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000451">
        <property type="protein sequence ID" value="VDN54264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PED0"/>
    <dbReference type="STRING" id="318479.A0A3P7PED0"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="180" mass="20268" checksum="49C402247B7DC1AE" modified="2019-02-13" version="1">MHKDVIVQSPTGSGKTLAYLLSVFAILLKVKQIWLAKETAALILVPNRELALQIFDVANHFGEALNIRIRVLLGGKKSKYYAKKVADEGFSHGCNLSSLINLIYHCVISFCRSIFSVNVLIATPGRLEHLIVSDGNFKKSLKSLEILIVDEADRFTESVFKRRYCNVFTSSIFCFEESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PL15</accession>
    <name>A0A3P7PL15_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase tensin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PL15"/>
    <dbReference type="STRING" id="318479.A0A3P7PL15"/>
    <dbReference type="OrthoDB" id="6273691at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18514" checksum="E57B0529947BC3F4" modified="2019-02-13" version="1">MQIFNVSKKRSDLTRLHPVVELGWPQELAPPLDRLCSICKMFENWLAANRENVIVVHCKTARSRAAIVIAAYMHYINICSLSKSVSECLAMQQFVDEFIGANGQPSHKRYIGYFSSLLSGKTKINPLTIYLQQIVLINFANRNILFKLYERMQPVYTTQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYP4</accession>
    <name>A0A3P7PYP4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
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        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31210" checksum="15FED1A33D234D0A" modified="2019-02-13" version="1">MLNIVSLVAVLHRLRFDESSNHPSYIPIIAILFINLFLSCLLFLPSKAFLTSSGVFNEFGCNLYGSVDLCLSLLQINSASFIALDRYIVTVTPSWLSSGSKAEKYIGFLTTTFLLFFLIPSCSTGALYYSIIEHVKESSQKNRDDSLNQNVHCPWASEQYISVTCLICLLATTTPYLPYAIACLNPFDRNFADISYNVTPVILSRLSTIFAPIAFVWMNDSICKKRQTNRLQRMSTYHTITAIAEVPTISCSILAPAIVRRQLPKVPEHFLEKANAISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PZ06</accession>
    <name>A0A3P7PZ06_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PZ06"/>
    <dbReference type="STRING" id="318479.A0A3P7PZ06"/>
    <dbReference type="OrthoDB" id="5917530at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018078313" evidence="6">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="205" mass="23465" checksum="4D3229DDD5FD0DCD" modified="2019-02-13" version="1">MGIILFFIALLLPGWTNIDFINVEQENVHVALGVWGEWRTVMNGTMRRAEWIPHFPNPSETVLRLADADLKHYYRSQMVIGIIALVLMVANNCLAIYSFYHHRYMYKRLTACLHIVIAMCIVIVIEVLSKSINEWNLSVAQQSVDRDWDYSVGQTTGYPSYMAYACVFIYIFAAIAFAVSSHKQKGSRAATAEFEIEDRPIHIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q2Z2</accession>
    <name>A0A3P7Q2Z2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q2Z2"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13510" checksum="C8741FC0B45588CC" modified="2019-02-13" version="1">MVYEMLTYILFIFEGSILTIFNSYMLLNVIIKKLNRQQYKSFISCFAFDILFGLTYISIGTYRIIIIPDKLTSRFDCLMNIHGWLMVGVFPLSGLLVLAVAMDRTFFILSFYIGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q348</accession>
    <name>A0A3P7Q348_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q348"/>
    <dbReference type="OrthoDB" id="7249367at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="122" mass="14066" checksum="3964B11B89BD805D" modified="2019-02-13" version="1">MFIEKQFTVEGFLNGAIQINGFHGFFAFKAANICGTYISDGKWNSLKSVMTDDAIEKVRRNFNSFTDEERELMRFSLDDVVSSFIFSSSIISRNFIRGLIARSIHPLGAWRIIEVNFFDFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q7S1</accession>
    <name>A0A3P7Q7S1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Neur_chan_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q7S1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q7S1"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000027">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="223"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="48050" checksum="5BDE3F8A255048C8" modified="2019-02-13" version="1">MAQKTEKDLVGYLLKNYDRRIRPTKYWNSSMTITIQIHLYSLIDVDEVSEQLTLLLWIPQSWKDEYLVWNEDEWEGISKINIPAEYIWIPDGTIFNIVDVKEILSLSQTYARITSHGQVEVDFNKLVSIRCPMDVRNFPFDLQFCKIQFGSWGFQLHQLTHNVKSAVIIPETSENSEWQIESFSSKKVQTAYESSQGDNINEYEEIIYTIVLRRKPLYYIVVLLIPTYLIVSISIIGLFIPHSADGEREEKVSFGLTTLLTMTVVLGMVTGEMPKSSIGLPLLGQYVLIETGVSIFAIILSAVILICNERALNHCKPPPVWIQGLFHANVKNRKDPLCQPLLTKEKDYQRSASDQLGLTFAIRTLIEYYDEQRERDFNKNLWHRLFAFVDLISMLILLILNTFLTFYTFFPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QAD0</accession>
    <name>A0A3P7QAD0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QAD0"/>
    <dbReference type="STRING" id="318479.A0A3P7QAD0"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38284" checksum="23A5B150B41FAE8A" modified="2019-02-13" version="1">MYFHSGTCWLFDIVSILPTDKRPKKRNILAGVTLSYTYDSSSTISSSTLLPEAPDGGYGWIIVIASFLINFIGDGVSNSFGVIFPAIQDYFEASKTLSGIVASLFLSVPLLCGPFAGALTDIYDCRRMTIIGGFIAAAGSLLSFFASNIWIFSFTFAIVTAIGLSFCFNTAIVSVTFYFQIKESIIDWISGFKSLVIVPTFFTFLVSTFISSVFFDMPYVNFPEYAVKKHNASEAISSYLVSSIGITNMISTIACGLIADWKFIKPCVTTFYGIFVLLAGFCVAVAPFAQNYTQLLLLCSGFGVFISANHALSSVITVNLLCLYDFQTGFGILSLVEGIGSLIGPALVGMFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1D8</accession>
    <name>A0A0N4U1D8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM50 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4775</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1D8"/>
    <dbReference type="WBParaSite" id="DME_0000041501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000041501-mRNA-1"/>
        <property type="gene ID" value="DME_0000041501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="6">
        <location>
            <begin position="562"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000041501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="708" mass="81120" checksum="3104713AB1BEB8BB" modified="2016-06-08" version="2">MLANLRIRISISAFNHFASNSFSTTGNVYNRAKYIPRRALLYVPGSNLKMLQKVPQIKVDSLVLELEDGVAMNAKADARTNVKNYLDDLPNKGVHRCFELGVRINSVSSQLIHDDLKELAKAKHLPHAFMVPKVDSIDDLAVILDAFKTTYGEERISNSIINNWLFIFTTTDKDIDFGFWYLVFGISVLVFGIGILVFAFKENKGFFKDVRLVIWIESARAILDMPRIINAAMNLHKTINFFKLDAAVFGSDDFCADIGATRTKEGYENIYARQRFVTCCKAFGIQAIDSVYIDIKDIKGLKKQCEEGNGVSWGFDGKQSIHPSQIETILKSFLPSQEKIEWAQQLVKEFMEHEKRGEGAFTFRGQMIDRPLLLQAMNLVNLIDVVNKESNNKSDLQLQYILDTVPLKFLCSNIKTMSKADEGRLIHIAKKRERAKEAIEQRRRKIELETKNLKSGMKAKFTANYDTVEECMKSATVGLVTLDEMREKQKDVSEMRESQLVPQSLSRNEKIERGVLQNHRLGMDPTVETAFLPDRERESELTKLKDSLAKEWHALQEKEKNEEINVAFAYWDGSSHRKDLRMKKGNTISQFLARALELLKREFSELRSAVPESLMFVKEDLIIPHFYTFQDFIVTKAMGKTGPLYEFDAAGEIRLRQDAAVDCGESHPAKVVLRNWYEKNKHIYPASRWEAFVPNKEYRQTVDDLTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1F4</accession>
    <name>A0A0N4U1F4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4792</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1F4"/>
    <dbReference type="STRING" id="318479.A0A0N4U1F4"/>
    <dbReference type="WBParaSite" id="DME_0000043201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000043201-mRNA-1"/>
        <property type="gene ID" value="DME_0000043201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824609at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000043201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="765" mass="88198" checksum="A4FBC64F0C488955" modified="2015-12-09" version="1">MNFAENFASEYIHSILDFILAGNPIFMEPKRVNRIDLKISSENAVKFDSFSFISLRKQIYDSEKEKIISDWSKGNMLFESILQSSFETFWSTILHSNFFDIIDSYLESYPRPWEYEKLNNHLNSDLKLCSVVEEIYRKGLLLVVRLLIYQENEELFLDRDFHSELLFNSQLLSLDRLLKVVAIYSSSNRDMINWIIKKCLESCPQLGDELLNQAYVSELEMENVVSGCEQIMNISQPVDSTQNLDSQIIFFLETGIEILGNLSALISFLPHISFECISNCFLSLPSIIERLDACFSLSKCTSVIKNMPMIRKIISLMDIIRYHAIELFHSFLSIHPKVDNLACVIRKTFASERFIFYFNQLYPLNVILDGLYESGIYKDCDIRAMNILLNDISLRQINNISEEYRNNGMFINLGRTNDEKIQSIMNNLVDMLPHYSIHFIHLCLRHFGYNEEETTNALLCTDLLPLDLRALLNVEFNQEKLTTISAKNIVYFSDSNDCNSNENLILSPSPQNASNSKSNCLHKVTDNDNGNELSDLETIWNRLERIALICTNSSTNACPVSRESDSTCKETFLKRNRLEVFHIPEREKIALRPTYQKYRYVEEASSENNDCYDDEYDDAFGDRQLYNTIDFGDDDGLQKEEILDGVEPNRNHLIEESDNDIFSDDDQQENVGEGTKSNKKKSKFIMPIVEKNVPTSHIAANIGDNNKNDKGDLNKKENKASGSKRFPADTKNSSYTGGRQRQLKERHKGSSRRYLADKKRGSGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U219</accession>
    <name>A0A0N4U219_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5051</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U219"/>
    <dbReference type="STRING" id="318479.A0A0N4U219"/>
    <dbReference type="WBParaSite" id="DME_0000069101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000069101-mRNA-1"/>
        <property type="gene ID" value="DME_0000069101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000069101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32717" checksum="9488363C7809383E" modified="2015-12-09" version="1">MSLSSHYHAHKPNVPIIMEDVFGWVREGNTFQVRVWLDDSEHDLNIGDDHAFSLLHWASKEGHVSIVDLLLSRGARVNDTNMGDDTSLHLAAAHGHREVVVRLLARKADVSAVNEHGMTPLHYACFWGYVQIAEDLIRCGAQVGACNKKGQTSLDICQPQARNSIIELAKEYGQNINQKITFKDHNWSGTKTRTRDATLSRYTGVDMSSLSLSIKIAESHSGELWRGKWQGNDIVARILAIPDVTPRISREFQSEFPALRCYLFFHLKSRRIVILFYYKKFGHKSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2F5</accession>
    <name>A0A0N4U2F5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5217</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2F5"/>
    <dbReference type="WBParaSite" id="DME_0000085701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000085701-mRNA-1"/>
        <property type="gene ID" value="DME_0000085701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000085701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18345" checksum="BD41FE7F2621A8FF" modified="2015-12-09" version="1">MDVACSSEVRLPHVDCRVIIKPGSEQRYWLYYCGVSNQSRRNGVEIVISEKTRSVLIRSHVYAPTLCADDRHKDKFYVELQLLTSLLRGNMVIIEGDWNARVGHDIITRNSITNIAIRLTIYQSVTAGRILDNRSYWGAKTGNRRGSDHASSQDLYKTDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2S1</accession>
    <name>A0A0N4U2S1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5356</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2S1"/>
    <dbReference type="WBParaSite" id="DME_0000099601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000099601-mRNA-1"/>
        <property type="gene ID" value="DME_0000099601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160693" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000099601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16493" checksum="DD5721560EBD6485" modified="2015-12-09" version="1">MLIILSLSIILQRVIDTANVSSNPQDIANKLARAVVIKQCYKTVVLSIVDEIGELVEVVRPVMPISRCQDNKPVLCDTLFRIPSNVVADNLDELVYFFSFLRFFDNMNNAAHNIELPPNIQAFITTFFQRTLILDSNEARRIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Z4</accession>
    <name>A0A0N4U2Z4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3Beta_HSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5436</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Z4"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Z4"/>
    <dbReference type="WBParaSite" id="DME_0000107601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000107601-mRNA-1"/>
        <property type="gene ID" value="DME_0000107601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF355">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000107601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45976" checksum="80A2CC9F926E05BD" modified="2015-12-09" version="1">MEILESLISPSLQFYILVAPPLVNVSRTQNRRMYYRMCIIGGGGYFGQHIAKELQNFGHHTVLLDIKFVYVPYLKLDESLTTRIEGSMLDRSVLDAALRGCQACFHIAAYGMNGGASLEKDKVYHINVDGTKLVLERCKENKVERVVFASSVAILFTNKELHFVDESMPYPHPSQYYSHYSASKAIAEKMVLSSNSNSLRTCALRLRGIYGPGEPRSVERAVDLCSRGFLIATFDRTKGGCLTQYSGVHNSASAMRLAEEALRSGRAAGKAYNIVDDGPANSSKIQNLKIGKISALGKKLPSYKLPYAIVLAFAILSEQLYLWFGIEPFFTQLEVNISSITNTYSIERAKKDLGYKPINNHDLTSTIEYYKKLKEKKKNSPTSITDNNKIILLVSLFFIILFWLINKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3F2</accession>
    <name>A0A0N4U3F2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RB_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5616</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3F2"/>
    <dbReference type="STRING" id="318479.A0A0N4U3F2"/>
    <dbReference type="WBParaSite" id="DME_0000125601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000125601-mRNA-1"/>
        <property type="gene ID" value="DME_0000125601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000125601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32955" checksum="C82437771B48BE5F" modified="2015-12-09" version="1">MDRRPIVVNSLLCFIHNYRDSILTNDLKTIVHNYFSKSVVSVAYSTLIELLPQQNATMTDDTNCVESSNDGNISSSLISSPPTDIIHLYDYVAKNSQSPVIFVTADLSELPLTLITDELDSSSEILREIRQLKLFIQDALSGKIEHTRKSSVNGTDEFFTTARSLESKMNPISSSSDTTPTVSTVVSSSCFTPTTSSSFPPINPLALYPKANNHFEKKKNVGYRLDAMVKKLTENKRKERETIQMLGTPIWPTAQMVNTVAYINMIRSMTSMTAAAAAAAQSSMFPSTALPQPDNLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3U2</accession>
    <name>A0A0N4U3U2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 25 member 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5766</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3U2"/>
    <dbReference type="STRING" id="318479.A0A0N4U3U2"/>
    <dbReference type="WBParaSite" id="DME_0000140601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140601-mRNA-1"/>
        <property type="gene ID" value="DME_0000140601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25661" checksum="75F00EB24929E1EF" modified="2015-12-09" version="1">MARERVFRNLLRCVLLQPFDRIKTIVQQETTKNLLTIIRVVPGVTLYFNFLNIAQTFVPKDLNAHLSNLFLGFFSRSLVCTLLMPPTVIKTRLESNIYKDSNLFSVAKELVRQYGIAGLFKGSLPTILRDAPFSEGKDFSPLSRFVCGIIAGISACILTQPFDFIKTQMQLYPGKYRSFIQIIEVIYSKGNFSRFFCGFWLRAIRRTLMAAINWTIFDETAVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U403</accession>
    <name>A0A0N4U403_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5842</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fem-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U403"/>
    <dbReference type="STRING" id="318479.A0A0N4U403"/>
    <dbReference type="WBParaSite" id="DME_0000148201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000148201-mRNA-1"/>
        <property type="gene ID" value="DME_0000148201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071877at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF85">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG CG6966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000148201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67508" checksum="4567D93C70AA1971" modified="2015-12-09" version="1">MDGISYRAVVFNAARSGNVKRLQVFLEGRDNEWLQECLSCSEGNTPPIVIASKNGHLEVVKYLVAGAPALWAASAAGHYDVVRYLVEEGGADINQTTDSSSSPLRGACYDGHFKIVEYLVSRGADIELSNKHGHTPLMIAAFKKHDRIVKFLLDSGASPFKASARVKYSYSFDYHDSMHDAAEAGSWAIVQMLLRAGACNVPDEFGVTPMMCAALAGHITVIRILKAYAKPQDVRDALKLYGATLVDRNMDISGAIHIWTEALEYGFPNDKRERHEVYDGLTEIDSYADIRNVIGDPDAMRMQALIIRERILGRGHHETHYYIRYRGALYCDLGQNARGYQLWMHALNLQQEHLYAFHPLTTATIMCFVDTFVNNVNELIINRNADDRRQPVSRQNILSVFDKAVFEMERLLICDFIIGFAAGDVRLRTEDTLEEKPNEKKCFEFYVMASIQLMLLFNRISAFSSTSEGEESIKEQEDSELLFKIVFRFVFVCGQLSLYPLHVACNDKDKSLPSHFSCAPVIEMLIKAGIDVNLKDPLGNTALHVVLFNNQPRTSIIQLLLSHGAALLARNKADQTCFQLIFNKDFNVAEILNPTEVITLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U567</accession>
    <name>A0A0N4U567_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6334</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U567"/>
    <dbReference type="STRING" id="318479.A0A0N4U567"/>
    <dbReference type="WBParaSite" id="DME_0000197401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000197401-mRNA-1"/>
        <property type="gene ID" value="DME_0000197401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000197401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26587" checksum="205885D87824E2A2" modified="2015-12-09" version="1">MRIFYSSFLKLSFYLVSKEKIFFQLEKKAKVVKQSKNDAKIAAKQSKNDAKSVSQLGIKRKALDESAVTNLNKKAKVQKIFNLDILSEEQRRKEARDKCSLFVAGIPKKTKAQDLKSFFGWLIFADETHCDKAYDAISKQTLKGTPIKVDFCGVKSKMKKETQLPINPLELYISGFPPNTTKEQIFICIHFIFRFCFVTFANEADAKAAFDKGKSLKIGGQPVDVFYARIKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U603</accession>
    <name>A0A0N4U603_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor necrosis factor alpha-induced protein 8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6677</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U603"/>
    <dbReference type="WBParaSite" id="DME_0000231701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000231701-mRNA-1"/>
        <property type="gene ID" value="DME_0000231701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF1">
        <property type="entry name" value="PROTEIN SALIVARY GLANDS MARRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000231701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22844" checksum="BEB6CD4955AD4A1E" modified="2016-06-08" version="2">MMLHAATSLCVYINTDTNSCSLQQFNSSSIFIRAQKKLLSKVVSRNLIKFNNDTTTRIFDSFYRILKIFYNKKIAELVGLLVRSGYFQNNKQKENLIVLQRQIRMLSLTIISFTTVAYSYDRNYLMVLLAKVRKKLQIIVSENLSEKSMQRLQIIFEYIEKGDFLDALFNNNDTVYKTILLQIIVDLGILIENNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U661</accession>
    <name>A0A0N4U661_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease</fullName>
            <ecNumber evidence="14">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS6748</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U661"/>
    <dbReference type="STRING" id="318479.A0A0N4U661"/>
    <dbReference type="WBParaSite" id="DME_0000238801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000238801-mRNA-1"/>
        <property type="gene ID" value="DME_0000238801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000002">
        <property type="entry name" value="Endonuclease G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="16">
        <location>
            <begin position="79"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="15">
        <location>
            <begin position="80"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN56775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000238801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34720" checksum="717AC44F77622B07" modified="2015-12-09" version="1">MWAKYWRYGSYVGAVVTSFTAGIYCEKWNIGKVNAATATTLPAMPDLPTPAPQTDTKVLPSRTAEIMQYGYPGFDNLRTFEDFVLSYDHFLYRTAHWVVEHLRPDKMVYHPSIDRSKSNFHEDASIHPYFRSTNDDYKGSGYDRGHLAAAGNHRTSQTSIDQTFVLSNMSPQVGKGFNRDKWNELEKRVRKLARKNLNVFVCTGPLYLPRLESDGSMYIKYKVIGKNNVAVPTHFFKVILIEFTKGQYDIEAYVMPNSAIPDSIELSTFLTPVNSIERSAGFHIFNKLPKSSLRYVNGKKAGSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6B1</accession>
    <name>A0A0N4U6B1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6808</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6B1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6B1"/>
    <dbReference type="WBParaSite" id="DME_0000244801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000244801-mRNA-1"/>
        <property type="gene ID" value="DME_0000244801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="114"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="305"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000244801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="72512" checksum="CEE8B88C12F23D15" modified="2015-12-09" version="1">MSGSPLDNRNTGELSALPGFLDRHICRGIVLEVKEDSIFSIPGTASDRAAGKCQRKERNEKEMKKKRNIEKTVKCAEETNITASFQDFGFDERLLKAIGELGWERPTFIQQNMIPLILENKNVTARARTGSGKTAAFMLPIIEKVIQLRNMSSNEKLYGPFALFISPTKELSKQAYILLNKLTSTFPFLNSMNFAELDAANEDIWLKEHPDMIVSTPGRLLHALNKLPDFCKNVRHVVLDEADLLLSYGYEAEMKRLRSFLPQQYQVIFTSATLNEDIGPIKNLFANGKVVVLRLKESQLPGLDQLTQYHICCQNDEERFAIFISLFKLKLIVGKSIIFVSNTNRCYQLGLFLQGFKIRSCILNAEMPVNSRCNVIKEFNDGKYYNIIASDIHDVIEEFSPNLAKNMFQKKNKNLKKKLPRHMDKESGVARGIDFHHVSNVINFDFPTSVDLYIHRVGRTARGWNKGTALSFAIPDERPYLEEIQKEINEQLGDNAIVPYEIRIKDLESFLLRTRDVLAACTRTVIREARLAEIRAEILRSKRLETYFAKNPREKSTLEHDRKLYTLSLHSPAIADVPNYIVPISLRGKAVDVERPKNNRKRHQRNEKERLTFNQKRFKRKQEDPLQSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U708</accession>
    <name>A0A0N4U708_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7104</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U708"/>
    <dbReference type="STRING" id="318479.A0A0N4U708"/>
    <dbReference type="WBParaSite" id="DME_0000274401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000274401-mRNA-1"/>
        <property type="gene ID" value="DME_0000274401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000274401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18378" checksum="A28C76CBB94432C5" modified="2015-12-09" version="1">MATAAASVQPPSSNRISGATATATITTPHGNDNASSSLCIGTPATSSSSSSSSNITHQPVVGLVAPPREICIELCVVCGDKASGRHYGAVSCEGCKGFFKRSIRKQARIIAYRTITNRRGYLHVDSIGYVCRGTKDCPVTKFHRNRCQYCRLRKCLTMGMRSECKIHFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U783</accession>
    <name>A0A0N4U783_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TLE_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS61</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U783"/>
    <dbReference type="STRING" id="318479.A0A0N4U783"/>
    <dbReference type="WBParaSite" id="DME_0000283201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000283201-mRNA-1"/>
        <property type="gene ID" value="DME_0000283201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2624652at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="9">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
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            <begin position="539"/>
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        <location>
            <begin position="149"/>
            <end position="230"/>
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        <location>
            <begin position="7"/>
            <end position="41"/>
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            <begin position="150"/>
            <end position="160"/>
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            <begin position="161"/>
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            <begin position="183"/>
            <end position="195"/>
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            <begin position="196"/>
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            <begin position="216"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000283201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="67058" checksum="61C7C43037EA0A77" modified="2015-12-09" version="1">MTLLDHLERIKEEYNYLQNQIQQQRVEIEKLSQEKETMQRHYMMYYEMSYGLNVEMHKQTEIAKRYNAILSQIIPLLPAEHQQSALNAMERARSLSIAELQAIGGQVHAQQQLAMLPGMAMGAPIGLAAQAPFHPSMAAVAAVAAAGMAKPDEKNDERNSSRTSRPRSSTPEPSSKRAKMESEDGDGDLEIDVQNDDPSNASASNGVNLKKDGRESAQSASSGDSTPNKARMANALAPADMNAVASSLLVNPALASFAGRSGLPTILDPHTQARFMAGMGQATASMPNGKPSYAFKTTESGQLQPVNFPHDALMGPGIPRIARKVHDLQHGEVVCAVTISQQNRNVYTGGKGCVKIWDISRTDSSKTVISTLECLKDNYIRSCKLFNDGSTLIVGGEAPTITIWDLATEKIKVELDSEAQACYALAVSPDNKLCFSCSADGKIIIWDLDSKKMITCLPGHQDGASCVDLSSDSLRLWSGGLDNTVRSWDLRERVQLQQHDFASQIFSLGCCPTDDWVAVGMENSNVEVLHVNKQDRYSLHMHESCVLSLKFAHSGKWFISTGKDNVLNAWRTPYGASLLTAKESSSVLSCDISSDDKYIVTGSGEKKATVYEVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U787</accession>
    <name>A0A0N4U787_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS66</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U787"/>
    <dbReference type="STRING" id="318479.A0A0N4U787"/>
    <dbReference type="WBParaSite" id="DME_0000283701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000283701-mRNA-1"/>
        <property type="gene ID" value="DME_0000283701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="353"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000283701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="771" mass="86936" checksum="C9142660E3EBF2E2" modified="2015-12-09" version="1">MRSTTASPSARSSISDENSPRNDSQITDDITAPQSTLSLLEYGSEMDMSSQENVESHAPRIRRPEFSGLPFQNRTIRMESARIRHPSEEHSFYLDLIDNIQVTQNPVLDVNLQHIWCFNRALYRQIICYPSEIIPYLDIVVNNIFAERFTQKLHCPIEIRPFNAEQTRSMRDLNPSDIDQLISITGMITRLSPLIPEMRQAFFQCSACSFSVDVEVELGRIEEPTLCANCQQPLTFQLIHNRCRFIDKQLIKLQESPDDMPAGQTPHTVTLFAYGSLVESVQPGDRVNVTGIFRAKAVRVNPRTRNTSAVYRTNIDVFHFNKVDKKKLRIAENVTLSSERMEQILRIAQQNDIVELLCNAIAPSIHGHMDVKLGILCLLFGGTFKPEMKERGRVRTEINMLLCGDPGTSKSQILQYVYRLVPRAQYTSGKGSSAVGLTAAIARDPDTRNMVLQTGALVLADNGVCCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVDSQWNRNKTIIDNIQLPHTLLSRFDLIFLMVDEQSEARDRQLANHLVSLFFEDAENTEGQMLDAGFLRDYIAYAHKFVHPVISEAASVSLINKYLEMRRAGSQFGQISAYPRQLESLIRLSEAFAKIHLRNIVGVGDVESAYELYREALRQSAVDPTTGRVDVNILTAGVTARTRKLIEQLADAIQTELIPHHGISIAANIVMTQLRQKNFVRVFISFFTSARISFTKELFDDAVAELIKKEMLVRIGDKLRFVGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D4</accession>
    <name>A0A0N4U7D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS122</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7D4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7D4"/>
    <dbReference type="WBParaSite" id="DME_0000289301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000289301-mRNA-1"/>
        <property type="gene ID" value="DME_0000289301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000289301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16418" checksum="58C0B1D09FBE9EFE" modified="2015-12-09" version="1">MSDRIQTIVLYRGFGSTNINGEKKVQSTRHSLGFSIVGGIDSPRGPMGIFVKTIYANGIAARSGLLRKGDEILSVNGNELCGKTHLQALQIFRKYSKVDVTLCIKKQLIRKESDDKRRIRSFCNKDLTDNKSNKQWYPLQRCNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7F4</accession>
    <name>A0A0N4U7F4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS143</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7F4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7F4"/>
    <dbReference type="WBParaSite" id="DME_0000291401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000291401-mRNA-1"/>
        <property type="gene ID" value="DME_0000291401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000014">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000291401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="644" mass="73571" checksum="8BBFE7EDB7D29D20" modified="2015-12-09" version="1">MEGPLSKWTNVVHGWQFRWFLLKNDALCYYTSREKMKKKQLRGCIRLRGAVIGIDGENTSLFTLTVDGKTFHLQGRDQKERDNWVRALETTIHELSGYYKPSSVQSLSITLKCKVRSLENLNSTVNDQNDSLSEIIQTTNCLMDIVKHSIILLQMARNRVNGDSGSSKDLLDDCSDEENQSSMRKAEIVSPISYSSSEDEFFDAEGLSEENSPSKIAGDRDGRIHFKSTLIEPVYNDDNEDFDAIYDDSEEHEVGDMQQQHGSVLMHLLSQVSVGMDLTKVTLPTFILERRSLLEMYADFFAHPDDFIASAVHSTPEQRFIAVVKYYLGAFYAARKSGVAKKPYNPILGEIFRCRWTLQDLPKTGVKTVRGPFPGSDLSQLTFIAEQVSHHPPISAFYAELPSQKISLNAHIWTKSSFLGLSIGVTNIGWASVKLHEFDEEYRVTFPNGYGRSIMSTPWIELGGKVNVNCDKTGYYAEITFLTKPFFGGKAHRIEGSIYRPGLKKPILTIKGEWNGLIYAKPFSGDEYEMVNVREKLEVKKECVPVAEQGDRESRRLWRHVTVGLKKNQINDATAAKRWIEQRQRDEAKYRQVYFSSSWNLKQCTVNVFIDLSFQENGISYQPQYFEKSGDDWIYKDVFRNDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U842</accession>
    <name>A0A0N4U842_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7347</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U842"/>
    <dbReference type="WBParaSite" id="DME_0000318801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000318801-mRNA-1"/>
        <property type="gene ID" value="DME_0000318801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796844at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000318801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66817" checksum="87CB7A5DF71E3665" modified="2015-12-09" version="1">MNERNYSAKYHLELCMKEDLDYSVGKSHLRLASLYNDYEQLSADLCELQFSIKWNRANEAAVVLERLVKSHSSDAVWTLIHKIFLKGSSCAVCSEREIFTVITPELYDSIVGGLTKRFDSDESLKIKMLLFGLEVLMEDKLNRIVNRALTFFTERANIDKDLDSGAGKYHVILGVIVAKLLNNRNLSQISPSRLYSVIAITLNVAVAWPLHDDKWFEILTNISPLYLTDANNYHQDRWYILSGLIDRYIQTFENDITINLQANLKYPSGCGGLVKCFDKVITLKTETKKSVLLFFVWLAYCIWKTFNQGNFLAWIPENDWSGDVHKVIQSKADVGPDKPTLTKRARTKDRRDIGSFPSTSVLKRSKKELCDSYELCSATILVFLQSMNIEPDEHMRFASSFPDLYQFVSESLLFEHRVDEALTHLNDVIDHSIKDSIASSKVYTSTAVSHDNDCILGSLMVLSQINFAWKGYLCFNRIMRYVEAKGSLVYPGMLKYITNIAILEELARVQEYCSEYVSVQIASPQGNRRIGQSTRHSVRGTKDGQKQSLEDQMKRWREEPVHVVKSYFIKNKEDIIKMLEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8C1</accession>
    <name>A0A0N4U8C1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7442</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8C1"/>
    <dbReference type="WBParaSite" id="DME_0000328301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000328301-mRNA-1"/>
        <property type="gene ID" value="DME_0000328301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000328301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16340" checksum="DDAF8E4B21F0D612" modified="2015-12-09" version="1">MDTINPSVVDNESTLGIYRWSSINPTLLSTDSDNSVNFCRPIKIEHPFEMDAEQSYRISSPSQLTSKNTTTSSATTIPLASCATAAASISSAFCRRSSGFIKSVSTYENSFLNLICCVLSQLKNQQVVLLFLICICILCCIAIFNYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8L8</accession>
    <name>A0A0N4U8L8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8L8"/>
    <dbReference type="WBParaSite" id="DME_0000339901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000339901-mRNA-1"/>
        <property type="gene ID" value="DME_0000339901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000339901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23724" checksum="29043D8BA8CC9382" modified="2015-12-09" version="1">MIFVGQYIAVEELGCFYQSVKSFSEGDQIVIVGGRLQSFVGSSYTANDEDFGIINRRRCQIYVAAFGGEDVVASSLVVYEGIQQSCDIKLNMNHWKAACIDKWPSDISKIGIFFRCVARCNDFLRNNPTLENSIFLIFVRNFRVDHAPKVPYFYRETFSDVELCGCTTLGEIGCCVPKSPLVDSSLSEKNVDYDLAFSIVFAIIGFRKANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U942</accession>
    <name>A0A0N4U942_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS7591</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U942"/>
    <dbReference type="STRING" id="318479.A0A0N4U942"/>
    <dbReference type="WBParaSite" id="DME_0000358601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000358601-mRNA-1"/>
        <property type="gene ID" value="DME_0000358601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN57618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000358601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37553" checksum="F1D94CDAAE520591" modified="2015-12-09" version="1">MLDRRYRVYGFTGAGVFGNVVRATDAARSNIPVAVKIIRNNEVMRKTGMKELDILRKLNEADRDDRYHCLQLFGHFYHSHHLCLVFESLSMNLRELLKKYGNNVGLHMKAVRSYTQQLLLALRLLKKCNILHADIKPDNILVNESKMTLKLCDFGSACHVADVELAPYLVSRFYRAPEIMLGLPYDFSIDLWSVAVTLYEVYTGKIMFPGKSNNQMLKFMMDLKGKFPNKVIRKAQLKDQHFDLNCNFLYHEVDKVTRRDKVTTLSVVKVTRDLEIELLGEQELDKQGMKKLEQFRSLLDAMVTLDSSKRITCGEALKHPFVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U989</accession>
    <name>A0A0N4U989_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7643</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U989"/>
    <dbReference type="WBParaSite" id="DME_0000363801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000363801-mRNA-1"/>
        <property type="gene ID" value="DME_0000363801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000363801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36387" checksum="064EFFC9E5830060" modified="2015-12-09" version="1">MDFKVKKRKIGKTLSLQGKSERAHHITKSESMKSLSSNYGHNVINSKQQMITLENVEISIRNIAADEFKRMKNISYTKRKPFKLSEQSEKKACGFISKNILECSNTEFLTRNKIKYANDDQQLIYKKLEKSYKIVNESNEHVDLCTAHEGCNTRDLIYYPSAIANGKHWKNEKKFVKSKLFFIYLLQTLIGLFLNLKEPLFQFAEFCKKHSTRTRILMALFIVYFIILYLDLIVALLEMFLQFIWPFTHIFFQILRRLMLSSAAAIRSFDHLLNAAYCDIAEIWCQNFKMMCENRCSFLFITLEQLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAI4</accession>
    <name>A0A0N4UAI4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8044</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAI4"/>
    <dbReference type="STRING" id="318479.A0A0N4UAI4"/>
    <dbReference type="WBParaSite" id="DME_0000416101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000416101-mRNA-1"/>
        <property type="gene ID" value="DME_0000416101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000416101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16790" checksum="ECF8ED1172E74FC4" modified="2015-12-09" version="1">MVIGFRPSVWDPTLIVGQIICIQSTFYASESILLSTSSFFGYMVSLRDIFSAQVTPRLVVIQLLADCICALMLSRIVCRAKQCLDFTSTLHFWHILAVILYDKIPFQASFWLLQVFSLVISTVLSEYICLQLETREIFLSTNSKYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAR4</accession>
    <name>A0A0N4UAR4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8138</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAR4"/>
    <dbReference type="STRING" id="318479.A0A0N4UAR4"/>
    <dbReference type="WBParaSite" id="DME_0000425501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000425501-mRNA-1"/>
        <property type="gene ID" value="DME_0000425501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF198">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000425501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22830" checksum="A4DCFCCA982A30AA" modified="2015-12-09" version="1">MNETLMKEFDRVIWIALERLLGMGDYYNETLVRLRGGLILRNAVEEIEKRLNCKDTDNCLYFYGLSAHDVTLVALFSLFNEISQFLGEIPHIGYGANVVFELWNINGQYKIKILYANQYDEEPFPITKFAKGCDGKEEFCDISNFLNASHSLYPSDLIKECASTSREINLDSESDGKLVKRAIETDYLDEILEPLLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB01</accession>
    <name>A0A0N4UB01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GBD/FH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8242</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB01"/>
    <dbReference type="STRING" id="318479.A0A0N4UB01"/>
    <dbReference type="WBParaSite" id="DME_0000435901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000435901-mRNA-1"/>
        <property type="gene ID" value="DME_0000435901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000435901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34844" checksum="EAE52A75A727301D" modified="2015-12-09" version="1">MLKARQTASDVRVRPAGSFLVKKEKCEYHSDTTIQEIPNIGPDVKRLRLMTWKNMQEGFAKRLQEYNPTKLLEEILNNDDTTEKYLPASTPKSLERLQDFSNVCLIALTENEHISCIRLLIKIASATKVNAIILLSFQCILSIFQRSSLKQEIWNELSSFLCCDQRLSSYFILFFFSCFHPSSIHLSILAIFHFALSNSLLSNIHAKLACDLAQQSILSSDHNHRIAAINFFVAIFEAVRTSLFILVNLGEDICDFRWLENMLCKMADDCDARVRLAAVNGLSMLSRTERPLSFSVYGLMKEVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB68</accession>
    <name>A0A0N4UB68_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8314</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB68"/>
    <dbReference type="STRING" id="318479.A0A0N4UB68"/>
    <dbReference type="WBParaSite" id="DME_0000443101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000443101-mRNA-1"/>
        <property type="gene ID" value="DME_0000443101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10061508at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000443101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38597" checksum="51746A30632394D5" modified="2015-12-09" version="1">MKFISLKIDKRLDIQALRGLAIIYIMAFHIFPDKFTNGFIGVDIFFVLSGFLITMILDQSKPITAFVVADFFRKRIQRIFPAYYLLLTIVIIFGGSGHLINIDFEILLTDSIWAFIFLSNVHDWIKNNDYFAAVISFFITIGNFNFLLHTWSLAVEMQFYLLAPLIMKIRREFTYGNIIVIVISVLSLILHLEAQASQSFSFIFSRLWQFFCGTLAFHLSKMNNRIFVSDYYLKAWKALTILSLIIISPLSIIIHLNEKLCRILVTGAVTIIIAGKWQDLSEKYLTLLGLDFIGDLSYSLYLIHWPCIIFIKYIYDISYFDLNGFDFLFFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBV4</accession>
    <name>A0A0N4UBV4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 NT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8594</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBV4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBV4"/>
    <dbReference type="WBParaSite" id="DME_0000471101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000471101-mRNA-1"/>
        <property type="gene ID" value="DME_0000471101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000471101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38399" checksum="4C3E609ADB6F9023" modified="2015-12-09" version="1">MAFLKKKGFKFNVDLELLKLSDMPLVNAVLFAKVRLLEGGTFEGVTERVFLFNHAACWNARFNFSCRIPPDPVTGVLERCACRVSLRREQKGGKSYQKLGFVDINLSQFAASGVEGITQSFLLDGYGVNQRQDNSRIVVKIIMSHQSADPIFKVPRKESSMEEEFLNPVERRAPPSGNSNGYPNPSCVDTISSRSSSVDELYHDCDDFSVESLYSPLITSLDPSDKNKLGRMSISVPNVQSFDVIRRTTINNSAIPQNRRFSQDRSQIKCCESGITRIHATRVDAEDVIDQMLAETVMPSIKNHEDYSDQGLALFVSKDGEAVIGGNTLRSSGSFERVHIADAGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBW4</accession>
    <name>A0A0N4UBW4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBW4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBW4"/>
    <dbReference type="WBParaSite" id="DME_0000472201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472201-mRNA-1"/>
        <property type="gene ID" value="DME_0000472201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5783913at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41009" checksum="F9293A193776A40B" modified="2015-12-09" version="1">MNIVKNEGELDGTVEGSLFIDLHERHQIQPAKYIVQWKQRIYSKGKMDESGWITASIETEPEIRVIGMIPETYYRFMVTAVGPDGRIGGAVLSEWGEALKLDKPLYPPLGPLKVMTKFDNENGVSALISWPYSPPMRQPTINLSEDILAAIGTCYYRIIASNSTHLITSEFSLDVGIGYLFSHLQFANEYIVSLYSLPSLYYSLELNLSTSIQTRFTTLSCNQIFGPGSLNCAPEPVQNLRGEIFPNGTTYIQWTPASDHSSILTYQLLYYAISQNSYCAMNPVNMYLDAKLKNACFMNFMQIFIAYHHYDKSEFQTVSSATIILSPSYPCEYLIRLTNYDLLGSNLLHITIPYLVNRRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC72</accession>
    <name>A0A0N4UC72_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC72"/>
    <dbReference type="WBParaSite" id="DME_0000485201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000485201-mRNA-1"/>
        <property type="gene ID" value="DME_0000485201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798673at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000485201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44441" checksum="472FDD49A12D8E97" modified="2016-06-08" version="2">MDEIPKKSNEVQSICNKVNATAESNENIDNDLLLSTAEEFDISEYERKLRENTEETMNLVMNLCDRSDKLKEQQKSTLLRSFLILQKEVITLKEFAGETKKDYNVGGRIEWHNVDSARFGDCFLTEPTSALILSNFNIFISDNNAGLFLFSIHSEFIRKVTNSNWKWPQAAAIYENNKILVSMMIKSEEDATTWKRFLVKFDENLNYIAKIEGPKWIEEETISRERLCVASTGFIYMAVSSQTFTALYELSPEGRWTELYYKKGQCFTDIQVLAVIGPITELFVVEEHRRYLWMLSIRESAICARKLLAVVEKPGAICVDDVGQFFIHDIGQGKIRQIDTKDNFEVISDIALADKSLYAISANKGFLAIIYREKNIIRLNKYKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCA2</accession>
    <name>A0A0N4UCA2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome biogenesis protein NOP53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS507</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCA2"/>
    <dbReference type="WBParaSite" id="DME_0000488601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000488601-mRNA-1"/>
        <property type="gene ID" value="DME_0000488601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000488601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29247" checksum="6B705188BC3A5E1B" modified="2015-12-09" version="1">MRRKTGKKIGRKGQKQIGQGMGEKNKGKTKENVSKQRQKMEKLMGNGADKRARQDNENDENAGKDTAGRAKALALTAGGITFGVQKLLGTSEDARTVGSNDPHQKQIIANIRFLKDSREVESIPPLNALILQEHAPSRKSATKVLRKETQNLPEQTINAPKLQSKTEISRQQEVSENIEIMPQQKIKISRMLKEDGIKSKKMKRAAVMEQSKMMNLTALAHIKGVFFKKNRFGAKFFAPNDQLTPDESELVEHSDESEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCG1</accession>
    <name>A0A0N4UCG1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8754</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCG1"/>
    <dbReference type="WBParaSite" id="DME_0000495501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000495501-mRNA-1"/>
        <property type="gene ID" value="DME_0000495501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000495501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27480" checksum="AC55ED3253D2BB72" modified="2015-12-09" version="1">MESNGKKERTHKREDILRIGENFVIYQSNASFLRVVDVILYGPNNWYIERNLIESGIVVHTTIRVMVPDHLIWPIDTTKWPIDYSYAGATYIAYMIAAAYAGGAISTNQSIYADILSIGLGGGSLNNFFRHITKNTNITIIEINKKMVDLAKTYFGLIEDDRQRCIVGDGAELIRKFAERGKKFDVIFLDACDTSEKISKCPSDVFMKSSIVKYFPKTLKKSGTLLINYIMIGEPLFPLEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCI3</accession>
    <name>A0A0N4UCI3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8778</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UCI3"/>
    <dbReference type="WBParaSite" id="DME_0000497901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000497901-mRNA-1"/>
        <property type="gene ID" value="DME_0000497901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984314at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000497901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34301" checksum="CA7FF3E4F37294F6" modified="2015-12-09" version="1">MRCACRACRFAKCVAVGMNPNAVQCNRTSRLASPKTEDTSDIASGDYPPGSCQLRFNTLENSDFMVKSNGENALDLDTSKRGYTVSALLDLPQIPCSSLSPYNMREAVENISSLQRFDFGKRELSEESKKKITQFISLQNKIDEFIASNYEFRDSLLELLTKPSIFDRKLNLHKADENNDISVGREINQHVALVIEYAKTFEVFKWMNLKAKLYLLRSIIFIIVFFDISYNIYAKKMVYKSIAIEKKSKDVRQGSARYGYLLSISWTLNSVFKKYKDDVAKIGPHALTKELISDVIPVNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCK9</accession>
    <name>A0A0N4UCK9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8805</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCK9"/>
    <dbReference type="STRING" id="318479.A0A0N4UCK9"/>
    <dbReference type="WBParaSite" id="DME_0000500601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000500601-mRNA-1"/>
        <property type="gene ID" value="DME_0000500601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5811289at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37976">
        <property type="entry name" value="PROTEIN CBG16927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37976:SF3">
        <property type="entry name" value="PROTEIN CBG16927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229922" evidence="2">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000500601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28972" checksum="F9F2402E1B7F95F2" modified="2015-12-09" version="1">MIVQLLARRILIFAAFNILQISADNEISVKIERHFPCSDSSVTFRQNLGPSKENLRIKFPSYRSPGVKFTEEKNEQGHKCFRMSGGDVQVFPPGLDGKLKYYVHLETRIGIHGKPEKCVNADENGCGGIGSCVHCDICQNMGGTLKNFVRIYQKDKPANCSEDGLNAGIYKDLSLRICLPTKNELLPFLDENTHRAEQLWDLFVSSRARHGEIPLVIAARLFERPINKVSKKELNDLLHGSKAGMIGCHWIYATVSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEH8</accession>
    <name>A0A0N4UEH8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS779</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UEH8"/>
    <dbReference type="WBParaSite" id="DME_0000578501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000578501-mRNA-1"/>
        <property type="gene ID" value="DME_0000578501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF92">
        <property type="entry name" value="CIN85 AND CD2AP RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000578501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30585" checksum="99BDDC955BBEA0A2" modified="2015-12-09" version="1">MDEIVTGNVAKLVNRLSRDFSANRNSEINFRKSSNFAKIATVRFSYKGAHDDELDLEVDDVLEVIEDAEPGWMKGKLRSTGRVGLFPTNFVQTSTSELMKGRVFPGASISGKLDQENIHINFHEKNIPKNEEFDPRPQKEMARVLYTYKPCHDDELALQEVGAMVTIVSKTCADPGWYLAEIDGKEGLIPDNFVELIRPSTSITDAHRVAIIIIKNNFLLKFLLNEEGSIESHGNERLSHITINRPKQPNKRPPSTVFIKRVSFLKIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEZ5</accession>
    <name>A0A0N4UEZ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS916</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEZ5"/>
    <dbReference type="WBParaSite" id="DME_0000597701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000597701-mRNA-1"/>
        <property type="gene ID" value="DME_0000597701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000597701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32399" checksum="342590A7607E5F29" modified="2015-12-09" version="1">MAGEPSEFEINSNGKSIVVGDTKGNIISFQIMQRKDNLLSLTGESIRHKSSIRGIALNFTTDLLATCSNDPKICLSSFDSDYSKVGKQQMQISMQDNVRALTFMEDLANHSSILISAVGKFICITDCCSGITFRSLNGHTGCVTSLRTWNGCMFASSSTDKTIRIWDMRVCNAVKILGQLSKSASNHIFLSRNIWVKLLKFYPISFYLLLLINFCINKINDMKLCDNFSVSGAFSVDSGGRILIRGDCEGNLSAFDISTTKMIFSGKIFNSQVNCLRITNESRYVVASDRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF31</accession>
    <name>A0A0N4UF31_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS961</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF31"/>
    <dbReference type="STRING" id="318479.A0A0N4UF31"/>
    <dbReference type="WBParaSite" id="DME_0000602201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000602201-mRNA-1"/>
        <property type="gene ID" value="DME_0000602201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000602201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19117" checksum="285CC224C1EB57B1" modified="2015-12-09" version="1">MKLIESSDTVKFPKDVSFTINKRVITVTGPRGTLRRDFRHLSMEIQRVKKDTVRVRKWFGVRKEVAAIRTVCSHIENMIKGVTKGFRYKMRSVYAHFPINVSLQEKSSVVEIRNFLGEKYVRRVTLPDGVRATLSANQKDELIIDGNDIQLVSQAGNIFIFNSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF53</accession>
    <name>A0A0N4UF53_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS986</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF53"/>
    <dbReference type="STRING" id="318479.A0A0N4UF53"/>
    <dbReference type="WBParaSite" id="DME_0000604701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000604701-mRNA-1"/>
        <property type="gene ID" value="DME_0000604701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000604701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22697" checksum="1E09B4B75D577880" modified="2015-12-09" version="1">MQINENTKIVGESVVLVPYKRQHVVKYHNWMENASLRELTASERLSLDEEYEMQLSWANDGDKCTFIVLSRFLFEQQRNEINSMVGDVNVFINNEVGELEIMIAEEEWRKRGLAFETLKLMIRYCFDHLNLVKFVAKIDENNLPSILLFKKLGFIENSFNEVFREFHFILDSSNLFHVIGDVNLQIMIYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFY7</accession>
    <name>A0A0N4UFY7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9490</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFY7"/>
    <dbReference type="WBParaSite" id="DME_0000637901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000637901-mRNA-1"/>
        <property type="gene ID" value="DME_0000637901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF12">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="82"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000637901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55958" checksum="F8EF827FE57DF7E1" modified="2015-12-09" version="1">MDEELPSVIVAESMVLFRSTNLTCDEFFSDFLPPYKYISSTIVLWISFMLYVSLKKNTNYGIVSIRKSIDGLKNIEKTYITTLDVFRVVAIIWVIINHTGSEGRLDILQGLPSAEIFKSSIHNHPIFGALLGNSGLGVDIFLVLSGFLASISWSYQENKSFLPHYILFIAKRWVRIFPSLIIFIAIASSPFMQRILPRFYNSIVSSCGFTGTISHLIFLANWRSTPICFGYLWYLSLDMQFYIIAPLLFHLAYKSRISAILLSFALIVFSMAFRAFHCVLYNVCDQSDVDIPFISYEATDNSTTGRYTGLWEIYSRPFPKCGPFLIGFLAAQAFRQMHIKLSISKIYTSLTISSFAIFASIYGILPQYWHPKSGSTLYNVLYTAIFQTLFALALATMIFIFSNIHKRKKSNRLWMILARLTFSVYLVHMPIVFIFNYLKILQDATSPYILIAVVPFVALISFIVGFLFHIIFESPLTRLGMVTVQRLSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGD0</accession>
    <name>A0A0N4UGD0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysosomal-associated transmembrane protein 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9653</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGD0"/>
    <dbReference type="WBParaSite" id="DME_0000654201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000654201-mRNA-1"/>
        <property type="gene ID" value="DME_0000654201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809348at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000654201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25127" checksum="F61B4F370A27C2E9" modified="2015-12-09" version="1">MMANCLCCCCWPAYRCCLSLSLIDMIITAALYYRSADLFMQNFYHLDIFDISVLVVLTGFLICEILATITLILSYKKRIQRYVFPRITLLLGQFVTITIICIILIAYFGGFSPAINEFILNIYEYWSGDDLAKYDRQHFVNDLMMYAGGLFVLLLIFDIYIIFELYITRKYYISLNSPPGFVPVSEKDLSCDYKIEKNCGKPVVVSRPPPYNPNYSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGE1</accession>
    <name>A0A0N4UGE1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGE1"/>
    <dbReference type="STRING" id="318479.A0A0N4UGE1"/>
    <dbReference type="WBParaSite" id="DME_0000655901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000655901-mRNA-1"/>
        <property type="gene ID" value="DME_0000655901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000655901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8300" checksum="EFDA6F4435EBD4AD" modified="2015-12-09" version="1">MEIQDSRMRPNQAGFRPRRGRADQIFTSRRVLEHRFRYLQPTVTCFIDFAAAFDSIDGAALWSHSVNNNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGI4</accession>
    <name>A0A0N4UGI4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HCO3_cotransp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1250</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGI4"/>
    <dbReference type="STRING" id="318479.A0A0N4UGI4"/>
    <dbReference type="WBParaSite" id="DME_0000660601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000660601-mRNA-1"/>
        <property type="gene ID" value="DME_0000660601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000660601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18790" checksum="978AFA02B1BCA355" modified="2015-12-09" version="1">MDFVPNEIKEVAISIDSNLKMADSIRRRRLEQRDYGGRGLDDSLITSEDLMATEPDFDAAVIGAHLPHIYRLGSLKESNDNDDGNDDEHKLLLQHEKVSVDHSLSWFKRTKKSLHGDFTSICLLLFLYLLQGIPLGLIAAIPLVLSSRNVSFAQQAVFSFAYWPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGV9</accession>
    <name>A0A0N4UGV9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1362</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGV9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGV9"/>
    <dbReference type="WBParaSite" id="DME_0000674801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000674801-mRNA-1"/>
        <property type="gene ID" value="DME_0000674801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF2">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000674801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52597" checksum="D1033F91CCC2B6DA" modified="2015-12-09" version="1">MKTSIFSVVIEKYGWLADMHITDFFVDNHWNRLPKIWQKSFTDFHPSQWLEIIDGRLENAKIVLPLSFICFYNVLKVNSLRRTAVTGPKQFAYQCCFDKTSSDKIIDAGCGLGHLSRHLALRFHLNNKLLSIIAIEKNNYLYKRCDQLDQLISDRIERRLLNDPLYSNASTFILPNRIKLSVDKNSNLYSNKNSCDKLKCVIGLHACGDFSAMLLHHFIARSDIAVLILFPCCYHKFSVYDNSHRQKWKQTDEQYNTAAKYFPMSKVCQSFSLGYLSQELACHAIERFAKNTDRFRDSIHKIHCYRAILEWLFNKLREKDKSSLHTYKHLGLKSVKISDHMTFFQYMEKALANRQHILIKIDDLLQNEPWIHTKVEEMIGRWKDVFAFYCLRMLMAPFIETILLEDRRYLIKEYGHDAFLIPVFDPLISARNLALICIKKKDCSSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHZ5</accession>
    <name>A0A0N4UHZ5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="4">2.4.1.132</ecNumber>
            <ecNumber evidence="4">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1674</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2 4">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3 4">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="4"/>
    <dbReference type="EC" id="2.4.1.257" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHZ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UHZ5"/>
    <dbReference type="WBParaSite" id="DME_0000720301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000720301-mRNA-1"/>
        <property type="gene ID" value="DME_0000720301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF2">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="5">
        <location>
            <begin position="168"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000720301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39903" checksum="B981FAB02C6ACA6E" modified="2015-12-09" version="1">MSSDARKSSGLDYNEKSFIYLSTSYSEIRNINLALHPGDWFSQNVALGFQLLLSDLDPDLIVIDHSASCVPLLKWRFPKVKILFYCHFPQQLVTPSRFFLYRWYSKLIALLEGTMFQYADLIMVNSHFTERQFLRVMPEVNISKLMVVYPPCDVDAVSIGDKAISRFDRPRNTRYTFLSMNRFWPEKRLDIIVEAAVILKRKNYYPRILLAGSVMPHIPESRIYYEILRKMVIKLDVADVIEFLDSPTEAEKFALYRACDTVIYTPPDEHFGIVPIEALEQRRPVIVCNSGGPAETVLEGITGSKINDPDGGLMAKAMEEHILKGVWPELDYDNEYMQQVKILKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIJ4</accession>
    <name>A0A0N4UIJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Complex I subunit B13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10065</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIJ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UIJ4"/>
    <dbReference type="WBParaSite" id="DME_0000742701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000742701-mRNA-1"/>
        <property type="gene ID" value="DME_0000742701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000742701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15281" checksum="58BDFD1667C0E94D" modified="2015-12-09" version="1">MVTVRGPNFASYGDRQINKLILQTTGLTGLFVNENPHRSLKIVYGRILRTLEEIPVSAAYRKYTEQVIKRRLAIVEQESDIEKLEQKIGMGQVEELIEQAEYELQAARAVLDNKAWEDLVEVAPEEQWRWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIX9</accession>
    <name>A0A0N4UIX9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-mRNA-splicing factor CWC25 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1849</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UIX9"/>
    <dbReference type="WBParaSite" id="DME_0000758201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000758201-mRNA-1"/>
        <property type="gene ID" value="DME_0000758201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000758201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="30006" checksum="1EE1804B61AA7B0F" modified="2015-12-09" version="1">MERSDLKWMYEGSKSLINREDYLLGKRIDKNFEKYSDVVNEEKETGIDSVVQNRLFTLSPSASKISNLEISVVRSEDPLVAIKMKQEKLKQERLENPLVLLKMKKFLRKAMEKKDDETKRHKKSCPKKHGSKRYRASRFAAEHEKKAKDYKKYRHHDSNLEQKNKHLTKISDDEMEKKRQEMLKNADWRNSARKNNVKAAAIQDEYEERNNQNKAVDFIRPMLNKAASALTIEKSLNSKRQHLQKSYGYMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJL4</accession>
    <name>A0A0N4UJL4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2008</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJL4"/>
    <dbReference type="WBParaSite" id="DME_0000785701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000785701-mRNA-1"/>
        <property type="gene ID" value="DME_0000785701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000785701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34748" checksum="FE976A0390A30302" modified="2015-12-09" version="1">MAVRDSQMAKLAKPIRCSDFADKALAWIKSDGTRRSSRADQSTRKSTLSFFTSEQLSTCEEPTDPFENEDGTGSELGMQEVSREHSATGLAHAIAPLPPWLRGCHAHVTEMSRRRSALDRSAWERLAVVISGAEAMVHATKGKRMGFLSFSFHIFDMHQMHVVFILISSSYRVTHCDYELQPSSPSLVHAFYETNKNFPGKRCLKERIEPDKELSTRPFSTRQLPTFSPSLSIVMMTRNRPSSRGSTPAMSKTKIERLHVSDEYQTRGLGGPYNEEWPVKQFTIQDEQRGEKMKESRNGESLKSKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJS5</accession>
    <name>A0A0N4UJS5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 41A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2053</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJS5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJS5"/>
    <dbReference type="WBParaSite" id="DME_0000792801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000792801-mRNA-1"/>
        <property type="gene ID" value="DME_0000792801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF20">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000792801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28076" checksum="267D667ACD4BAA7D" modified="2015-12-09" version="1">MTRLIILPLIFMFASLALWTMIYSAPGSIFLRGPYDENFWELPGKFDNFTLLTEKLRYYKRDHYNYIVLLFILTYIYKQTFAIPGSFFLNIIAGILFEFWTGFLLVCVLSTIGSTFCYLISQLFGREYVLYYFGEKVTYLQQKIDSNSNYLLPFLLFVRMFPISPSWMFNIVAPFLNIPVSIFLFSAFIGLAPYNFICVQAGCIISELKNWRDIFDTKTVLKLTSFAFIPIAYAFFIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJU1</accession>
    <name>A0A0N4UJU1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2071</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJU1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJU1"/>
    <dbReference type="WBParaSite" id="DME_0000794601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000794601-mRNA-1"/>
        <property type="gene ID" value="DME_0000794601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263060at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000794601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27664" checksum="A2F7DAA5C86BECEF" modified="2015-12-09" version="1">GKSSIILRFLDRNDIPKPTIALEYTYGRRTTATVKDIGNIWEIGGGSSLINLIEIPITSSTIGVTSIVIIIDLTKPEDIWKIYKNILLYIKDYVHSLLETIKKDLPEKYNQLISINKNKFKNHQDVNAVNPFPIPLAIIATKYDEFQKMDPEIRKNVCKFLRFLAHMNGASLQMFSNKMENTVLKVRALISHLLFGTTPSKTIVTDYDKPISIPTSMDSLEVRFQYFLYFLLSIPLAAGSTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJU3</accession>
    <name>A0A0N4UJU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Movement protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2073</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJU3"/>
    <dbReference type="WBParaSite" id="DME_0000794801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000794801-mRNA-1"/>
        <property type="gene ID" value="DME_0000794801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5827459at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000794801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12459" checksum="6650A68165E4D726" modified="2015-12-09" version="1">VRSSGLHSNRQTVTVVEGLNRSLENELDSNRYSAWLGGQLTLQSQSRTGGFQKVRDVVSTSYYDRVMSERQQSLRPRSKVESFQNDKNDKDDNSEAICNSISALVMKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJV5</accession>
    <name>A0A0N4UJV5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2089</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJV5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJV5"/>
    <dbReference type="WBParaSite" id="DME_0000796401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000796401-mRNA-1"/>
        <property type="gene ID" value="DME_0000796401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790915at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF226">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042862" description="Fucosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="195"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000796401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36377" checksum="EFE392CC36D41120" modified="2015-12-09" version="1">MWKKLYIFCFSVLIVLLELKFHKIYENSIIQISIKGPIQSKLWWIHKSNIFFNWSQLDNSKKLRLVPLILSWNDSYSDIGKRAKKGIGNCDFKCEVTTDHRKYFSAGAIIFYYTFGNQMPPLRHHNQYYIFFCVESPLSIEQHTGSMYKEPFNLTVSYRKNSDIPVPYGELKQIDKSTLPDKIWKWEQASPKFIKNSSHRDLYTKNLAKYINVTVYGRCGLKLCMGHCEKLAVAKHRFYLAFENTICNEYVTEKAFKRLDQLLVPIVLKGSLYKNILPENSYIAADDFDSPEDLAKYLKYLESNATAYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJW8</accession>
    <name>A0A0N4UJW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2106</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UJW8"/>
    <dbReference type="WBParaSite" id="DME_0000798101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000798101-mRNA-1"/>
        <property type="gene ID" value="DME_0000798101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000798101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13468" checksum="F3BEC97BA795855B" modified="2015-12-09" version="1">MENVAKSSWSNDFDDFTQSHLEEIRDAFNIFDRDGDGRITTDELSTVMASLGQRPTKSELKNMISEFDEDGFLFYLFLPLAYLCIQFSYSFFLFFIAFIFHCSFRCHAFLYVCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK87</accession>
    <name>A0A0N4UK87_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase 2 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10253</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a 70 kDa and a 80 kDa subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001208">
        <property type="protein sequence ID" value="VDN60280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK87"/>
    <dbReference type="STRING" id="318479.A0A0N4UK87"/>
    <dbReference type="WBParaSite" id="DME_0000811701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000811701-mRNA-1"/>
        <property type="gene ID" value="DME_0000811701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="14">
        <location>
            <begin position="310"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000811701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="66127" checksum="433F04D21E68D0C9" modified="2015-12-09" version="1">MSDDDSNNDIDDDIAIDQSCSLSDSTRRCTIYIVDAADKMFQYQSDGKFCDFKRALKIVRLQMVNKAVTSNKGEYISIIFINTVKRSDSVDNVVIFQNIEEINADHVKHLDKLYKSAFYNNKIFFDDLSNAIYNICGGSGKADFSEVLFLCMKMIASCNTSFYKKVVYFFTNECQPFGLSERHLKSAAKNAEDLRKHGNDFAIFPLITAEQKLSSDFNTLQQLDPNVEENWENIAELEEDIPRKQYARRNICGIDFSLDEGLKFSVGIYSLIRPEKLPKAIALDAETNEVVQRTHIYVNEKTNIEVPLLDGEIMRRKFIGGTEVNLTAHEVELLRRLTPPGLVLLGFKPISCLKISHHKRSSQYVYPLESNAIGSTRLYRALYDVCLRQNKMIICRYTQKENVPPKLVALVPQAPVTENDQSSKMSAKFRYPGFHLVYLPFAEDKRDLSEYLCHPYGEWPKANDFQIDCARQFVRKLTSNYFPEKFANPVLQKHYKVIEAFALDYDDLEEFPDQTQPYFTNDAFRKRVETELSRLVSSTLPPNYFANLKFKPKVSKKSHHSGEFEEILMFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKL6</accession>
    <name>A0A0N4UKL6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PABC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2319</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKL6"/>
    <dbReference type="STRING" id="318479.A0A0N4UKL6"/>
    <dbReference type="WBParaSite" id="DME_0000828901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000828901-mRNA-1"/>
        <property type="gene ID" value="DME_0000828901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000828901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24258" checksum="9587C0E261797D3C" modified="2015-12-09" version="1">MNLLILECFIPFFTFAQNSIEQEILLAISKHSRKKHHSHKETRSRSHKKHSSSSSSGSSDLDVKHLPSSFRSSGANISDVKQSTSSVIELDKNEEICDLQSYINERSVLVRHVFASITRADLRKLLPGSLKNLEIKTLMTMCVDELEGMSNKRILAIIEGSDLLESSADEQDSGGLQESNNFAQSAHKGHHAEIAVADSTTSESFKKEGLPTNQTSCGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL79</accession>
    <name>A0A0N4UL79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2494</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000064">
        <property type="protein sequence ID" value="VDN52521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL79"/>
    <dbReference type="STRING" id="318479.A0A0N4UL79"/>
    <dbReference type="WBParaSite" id="DME_0000853801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000853801-mRNA-1"/>
        <property type="gene ID" value="DME_0000853801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000016">
        <property type="entry name" value="26S proteasome regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="221"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000853801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47779" checksum="4043CF62C74A5732" modified="2015-12-09" version="1">MSGGTTMDTMSSAPHMNEDNAIRYLTNFVKSPVSDELDIKKREESIMELGSMLAKNKRTLELRKMIENTRPFLVSLGKAKAAKLVRNLVDLCLMIDDQDGEIKVDLCKECIQWATDQNRTFLRQTLEARLVRLYNDLRRYQQAQQLANQLVRELKKVDDKDVIVEVQLEESKACYHLGNLSKARAALTSARTTANSIYMPPRMQAALDMQSGILHAAAERDFKTAFSYFYESFEGYDGVNETKEALRALKYMLLSKVIMLDAPDEVSSLLSGKLALKYSGTDLDAMRAIAEAAKKRSLSDFNAAFGRYREELQCDAVVKKHFNSLSDGMLEKDLCRIIEPYSYVQIDHIARKIGLDKDKVEKKLSQMILDKKFSGSLHQGDGMLIVYDIAPVDKTYEAAVETIHAMNEVIDALYHRVKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULA7</accession>
    <name>A0A0N4ULA7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10421</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULA7"/>
    <dbReference type="STRING" id="318479.A0A0N4ULA7"/>
    <dbReference type="WBParaSite" id="DME_0000857401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000857401-mRNA-1"/>
        <property type="gene ID" value="DME_0000857401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000857401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20441" checksum="2E2335D472C0FC71" modified="2015-12-09" version="1">MKSSEGNYTRRFVVNEDCITQEDDYIEAEIESRDSFHVNHTDLFGEKLLELKFSLFHTSDKNLSMNQHDDMLVPGTVPDNYYQSIMTVSNTNNILRKTINKITSLSAEQINSIDYRPISQCTYIVDNTRRKPIASRDFLPDVPDISNCSQESEYMAVFSSKPKILRTPENRRNSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULP9</accession>
    <name>A0A0N4ULP9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10465</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULP9"/>
    <dbReference type="WBParaSite" id="DME_0000873201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000873201-mRNA-1"/>
        <property type="gene ID" value="DME_0000873201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000873201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39357" checksum="1CAF50BD10F904FC" modified="2015-12-09" version="1">MSRAAATTNITKQTKSQKSQNETTEDGDNDDEKAAIISEIFRCTAEALEKIGRLIIRLHPTSHNSNERDHHVLRQDLTTSGEHGVKSIPGFAIGECASWVSKALDQPPIRKGCMLYHLYRKIPIKLNLSANYMQLRARGRERNYLYYSKAIKLEDFLKDVKIFKSLSNVLHKSLSTDLFSSMEERTPNDLSKSIMFLIPKKKLCSNLSLKNFSKWSKEIVGDMRNAIKNFSNNIVVIDEAVKRTNVDCIKRDMKRRRLASPVHVQNIPIKEIDCPAISRKRFLPSDQSPLIKNRRSIVADTEFKDTPQNISQQIRQDINPTVAPIPINHSNQQYHSDLTDLHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM22</accession>
    <name>A0A0N4UM22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10512</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM22"/>
    <dbReference type="STRING" id="318479.A0A0N4UM22"/>
    <dbReference type="WBParaSite" id="DME_0000887401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000887401-mRNA-1"/>
        <property type="gene ID" value="DME_0000887401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000887401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41939" checksum="EE38CFF807ADE619" modified="2015-12-09" version="1">MSTRNRRDLENRELEALAQFLPLADAITAQLDKASVVRLTCAYLALRRIFPELPERREQLSEIGSFLLQTLDGFVLFLDPEGKMMYVSETASVHLGLSQVELIGSSIFDFLHPDDEAELLFLLSAVDSKRVIYEVPYMEEIERMFFIRMRCVLPKRNAGITYSGYKTISCWGYSKIQHDKFGSMNLGVMAVGYMLSRSGVTEIKLPSSTFMFRARLDFSIIFMDTRITALTDFNASYLLEKSFYQIVMLEDTYIIEKAHRILLNKNQSTTGYYRILYRDKGYVWAQSQFCIVPMRRATITHCIVAVTEIFSERQSNLTYSYIQQNAAGNKSTASNCTLGEYSKAFYKGALLSANQFGRDKLKHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM91</accession>
    <name>A0A0N4UM91_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IstB_IS21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2782</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000080">
        <property type="protein sequence ID" value="VDN52809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM91"/>
    <dbReference type="WBParaSite" id="DME_0000895301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000895301-mRNA-1"/>
        <property type="gene ID" value="DME_0000895301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000895301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8665" checksum="54B90BEADBDCD145" modified="2015-12-09" version="1">MNYAILHSNIAWMKLETLFAHDFAFLEISQNLHYNYKRTILIDHIIQITEEEFDISKERIEANKNIYRKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNC0</accession>
    <name>A0A0N4UNC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3108</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000105">
        <property type="protein sequence ID" value="VDN53135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNC0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNC0"/>
    <dbReference type="WBParaSite" id="DME_0000939701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000939701-mRNA-1"/>
        <property type="gene ID" value="DME_0000939701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874601at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="453"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000939701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="737" mass="81056" checksum="9D83CC600FA33844" modified="2015-12-09" version="1">MKISSGKNIHFRHFTGIAGPSGVDFNPLIGNGIQSGPGIKIRINQRTFFYLSSLAKSVIEQIVPSARIPDVKERIEEVSDQSDNIDFRPPCDVLVYPAPNNLLVVKIDDFDVGVTGNLDGVVNVLLPIKLFGIVHANLYHVSITVTTALERTHTGQIYARVCGCDVNIGYADVCIECGGLVGDLVNAFARQTIAERVKNLVPARICEMLPSLVESRVNPMLARIPLYIPFSEITSSLNNILSPNIPPHCLSPICRARPSPTPPPLPTSTVARPPNNPPLPNFTNSTGFHRINAATLLKNGLHKNVVSNKIRLRPKRQIITMVSGNAKPETFTLVQTNSNLRTPRAHRRTSMRQQKLAQGVKSWNRNIRPLTNANGERGTLCAGCPPDDGSSAIKIFVLQQLRFERLSDVSLSLAILNLYANQYGFEIDIAGEFSPRGLGGTPFGPFPMQFPTPLGGSMIEILISDFTINSLLYAMHRRGFLTIRIGPEVPGIGALLKTTCEEEDYFDEEMADRKNSSSMVLLANRIRSLVNRRFNIKRRNKRQSDSDLSSLADLGVCLGDLSPPLKENYPNRSLALNIYTGRAPSTIFSGHGEVICNNKFNKFAGMVSVDIILFVDIYLDGTNIRVGSISIVIILDISVRIIGNRLTGNAVFRTLQLSDRLGTLGLDQDAFNNLANLARDTLTKAINDRLRNGFPIPLPVDKIPVQINNLNIQLIERAIYISADFIVPPALLNEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNL4</accession>
    <name>A0A0N4UNL4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLU-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3183</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000111">
        <property type="protein sequence ID" value="VDN53210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNL4"/>
    <dbReference type="STRING" id="318479.A0A0N4UNL4"/>
    <dbReference type="WBParaSite" id="DME_0000949701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000949701-mRNA-1"/>
        <property type="gene ID" value="DME_0000949701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific demethylase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000949701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47251" checksum="672B428411571315" modified="2015-12-09" version="1">MRQHAKKRLCDVQSLIKLATIKSYPPCAILVTALSAIKECERVAGIVVSLTTRSKESKRWDIFERRSENIGLIESLMKNLPCIDDDLQKVVDVRLCIRNYMDLSMNWKQRCTKILSDVSAINECSHSLIDPLSELIDEAHNLNLSLPEVLNLEKILKQCQWFLRSKKLLNWNHGEKKEENDRKEIIDYFKEECRWKLQNLMSFVDEGSTIMENNLAMQEVINALKLMVKLGYENEFAAEKFLSDKANEGIGYEKANEQWLLLEQTDWMTEKNIDCFRKEMVLAKKIRDMLYYYRESGTCTLRDLRNLVLDCSGSLFIRGTTIHDDVIGLYNGVNLFRENICQIFVNEPSYYSVFDIVSGRSDLPSIIDGTSSPLRLLYNYSTDEHWSKINNFITAEQLHNHGVISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNL7</accession>
    <name>A0A0N4UNL7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3186</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNL7"/>
    <dbReference type="STRING" id="318479.A0A0N4UNL7"/>
    <dbReference type="WBParaSite" id="DME_0000950001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000950001-mRNA-1"/>
        <property type="gene ID" value="DME_0000950001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871328at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000950001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7205" checksum="419903F72B7394A6" modified="2015-12-09" version="1">MSEPAVPLVLSRITIATTYHSREEPTSKDQKATSLWTLGCHKPVIPVVTFLTPLARDFLIQKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNP8</accession>
    <name>A0A0N4UNP8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001236">
        <property type="protein sequence ID" value="VDN60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNP8"/>
    <dbReference type="WBParaSite" id="DME_0000954301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000954301-mRNA-1"/>
        <property type="gene ID" value="DME_0000954301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798369at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000954301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20263" checksum="4C184772470564B5" modified="2015-12-09" version="1">MENCGEVKIKWNHHGVKHRFSISHIQLERDIVFATDKELRDLISQNRRIKIYTSAQKQSFKTYSHRSQFVPLDLSSHLHKSIARLEQNPPPPYSKSFEDAITSKELMIRSLRVPPPCYSTPSCYTRSLLYVSPPEPLIIRSLLFSPSLVAATATALNFPCAMVVATYGVECAAQVFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNQ7</accession>
    <name>A0A0N4UNQ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3221</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000114">
        <property type="protein sequence ID" value="VDN53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UNQ7"/>
    <dbReference type="WBParaSite" id="DME_0000955401-mRNA-1">
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        <property type="gene ID" value="DME_0000955401"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:outward rectifier potassium channel activity"/>
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    </dbReference>
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        <property type="term" value="F:potassium ion leak channel activity"/>
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    </dbReference>
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        <property type="term" value="P:stabilization of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF296">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans_2"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="106"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
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            <begin position="65"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP52</accession>
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            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3336</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="WBParaSite" id="DME_0000972001-mRNA-1">
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        <property type="gene ID" value="DME_0000972001"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000972001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12306" checksum="7CF2923238C4FCA3" modified="2015-12-09" version="1">MFYLKKEKTFDEFHKNISLFARETRRIDVSRRTTTTTPTATTTTTMRLMGCMIGHSTIGDEEREQRKVPLFLSIPFCHFYQWKERIKLFAANVMIGTVIVRVNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPS8</accession>
    <name>A0A0N4UPS8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3518</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000143">
        <property type="protein sequence ID" value="VDN53545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DME_0000997801"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000997801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20526" checksum="7121FF8E38569AD4" modified="2015-12-09" version="1">MSESVSNNLNENAPIDERNKIDSSVLSTPRRAFGDMKNAFVTPSRSTNCKNTNIIKKIKNDFEVFEEKDETVDYLSKKCESDVKKESSEEQFNRIDPDAPVDTVTFSDDSDDFLAPEFERDGNIVDLFCDMLMDDRLNQCIFSHWLTHEQMDLLKNGKPLYNGPLDLRILHVDPKHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPU3</accession>
    <name>A0A0N4UPU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3537</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000146">
        <property type="protein sequence ID" value="VDN53564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPU3"/>
    <dbReference type="STRING" id="318479.A0A0N4UPU3"/>
    <dbReference type="WBParaSite" id="DME_0000999701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000999701-mRNA-1"/>
        <property type="gene ID" value="DME_0000999701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069833at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01215">
        <property type="entry name" value="PTB_Dab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048561">
        <property type="entry name" value="Dab_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695:SF3">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="54"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000999701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50685" checksum="079DB77F5575893A" modified="2015-12-09" version="1">MVGQQRMKESTSDLCTENGSFGSPGSPKSRLAMLKRSSTKSKATINNDPFRFQGDGVDFKGKFIGVRDVTEARGDTMCAEAMRLAKAAVKSSGQHKQRIVLNISIDGLKIKDEKSQMTLYNFPVSRISFIARDTTDARAFGFIFGASDNKYKFYAVLSIRDMFQIVFEMKKAHLAQVKQKQEEQQKKDQPVVENGVRIDNGVAVADLLDLESELHNIEQGVNQLQNIPTFAEDSWPNADAFSTTLQPSFPPPAFAPYGAIPTAFSNTPVDPFGDSFNPNSALPSAISSYQMASAWPHISSVHSAPNFQSIPFSETNPFSFSYNLAQHNGQNGAMPSDPFDTHSAQQIIKESLAQRQINSVNWPTNENSVPPSHNENRSQWTEPRKVTSLEEAFTKLVDMDSLVSGPDIKKNPFEDLLNPPKVPIAAMANNRTSCMPARSAVPTLVCPGASNDPFNDDFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQB6</accession>
    <name>A0A0N4UQB6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3705</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000171">
        <property type="protein sequence ID" value="VDN53732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQB6"/>
    <dbReference type="WBParaSite" id="DME_0001019501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001019501-mRNA-1"/>
        <property type="gene ID" value="DME_0001019501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001019501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32905" checksum="E7595E96EC4A3622" modified="2015-12-09" version="1">MQENSVNPIAVATPSAGNVLVLLNTLYTSGFASHSPSQPLLSGRTMHTLYAISFVIYSVSCVVDWIYAYCTLRGYVTSFPLKTEIVVALVSIAVIGSMLNALLLAFNNFRIVFLFLAVHDFPITIINFFFIAACRCVGPKVWQWPVVIITLTTTANVIWRLIMLYIAYQRMICPMKKATRITSSVHNPSFMEQLKANTSQKGGGRLNEYDECWPTRYSYRKVFGDPEATEGREELIHFTMPQSKLARCICCNILVLLVYKFYLVVRLVAIITFIVSIAFIIDTNALDHLSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQC0</accession>
    <name>A0A0N4UQC0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase</fullName>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS3709</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01000171">
        <property type="protein sequence ID" value="VDN53736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQC0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQC0"/>
    <dbReference type="WBParaSite" id="DME_0001019901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001019901-mRNA-1"/>
        <property type="gene ID" value="DME_0001019901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="17">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="15">
        <location>
            <begin position="239"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="16">
        <location>
            <begin position="549"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN53736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0001019901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="887" mass="102694" checksum="378E2A7D1E2BCA75" modified="2015-12-09" version="1">MICHEHQKVPKRLERLPDIALPSHYTLVFTPDLEKFVFQGEEVIDVQVTKPTDYLKLHASAIDIQKASVTLKDGTEWNGLSIDYDQKWELITIRLPTEVQPQEIKISLVFTGILNDIMRGFYRSSYKDAGDVEKFMASTQFESSHARMCFPCWDEPIYKAKFDISLIVEQSLTALSNMNCIDEKIINGKKFVKFATSPLMSTYLVALVVGDLEFIEDKTNSGCIVRVYSTRGKKDKCYFALSVLKKTIGWYSDWFGIPYALPKCDMVAIPDFSMLLYIETDSYLPYLEAMENWGLLTFRELAVLTDPKKTSKRLETLIALVIAHEAAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVDANYPEYNVWLNFLNDELAHGFQLDALKSSHPIEIEIDNPNELDEIYDSITYSKSNSIIRMLCNMLGVKKFQEGLRIYLKRYQYKNAETVDLWDALSETSGLDVREFMSGWTKQMGYPLVVVQQEKKDGGIILHLRQEKFSFNPKQTNDTIWQVPITIASVSDPDNIKKILLLKNRENKFIMSEFKADDCLKLNVGTTGFYRVCYDCGSNQFATLYQCLREKKLSALDRFGLVCDMVAWLISSRHNAKIFLQLIEDLVNEDEYSVWSEINCGLAKILDLSNYYADKSIHNRLLSYIASRLEPVGMRLKWESSEDEEPQRKFLRSLILQRLASCNHLPTIDKAQKIFREHIDKNFDLNPDLRSMIYSTVAMYGGQAIYDELKQIYEKAELDEIKRHCILAMARIQDRRLRTQEYPVLFAGASLSNIGQKFLWPYFKRKSNFKDNVKLLVKNIGTVNSKLFINCYKSSADWMSFEGSTDDVQKFICSHLKEDEARTLNRTTEQILETISINTQMLKSTESDVSNFLTEKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQE6</accession>
    <name>A0A0N4UQE6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3736</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000176">
        <property type="protein sequence ID" value="VDN53763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQE6"/>
    <dbReference type="STRING" id="318479.A0A0N4UQE6"/>
    <dbReference type="WBParaSite" id="DME_0001023101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001023101-mRNA-1"/>
        <property type="gene ID" value="DME_0001023101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001023101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39759" checksum="D4061A7DC69C05BD" modified="2015-12-09" version="1">MALIINSEENFSDFIQIEYTLPFQGYRKYVAFAYILINALGFMANIWVLYMVAPLLFYVNIKVPKSILFFIITLCLSDLMIMIGMLFLIIEIIMGTWKFSEASCTIYLVFEAMNKFVAPVIVVLISRTCYVTVCLRNKQQKNAASLKVSVIFLFASMAIIMIVLWPVFAYSQVSSLFFRVNATEKTVFIMRKCSFTPPPGIELAFGIVSCISSYAIPLGGFIYWYVSVSFFLKKHVDSSLAFSSSNDSAMRRVAATVFVLTVVYVSCWTPYWLSIFAHKFISSMNRKIVIASYLIHLLPYISCSAYPVIFTLMNRRIKLARAELEKYNKRRIKTFGNNLITISFFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URA1</accession>
    <name>A0A0N4URA1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4003</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000243">
        <property type="protein sequence ID" value="VDN54030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URA1"/>
    <dbReference type="STRING" id="318479.A0A0N4URA1"/>
    <dbReference type="WBParaSite" id="DME_0001057501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001057501-mRNA-1"/>
        <property type="gene ID" value="DME_0001057501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001057501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37821" checksum="5BC7F74DB8BE67A9" modified="2015-12-09" version="1">MVFHGNGMSDVFGKQSNHFSLKFRNKEFDLDRWVEQTSCCMYLPENEMILLCDMLITRLSLLPNIIALSTPVTVCGDIHGQFYDLLKLFRQGGQIPQTKYIFMGDYVDRGYYSLETLTYLFSLLLRYPDSIVLLRGNHESRRISGVYGFYDECLQKYGHSIVWKWCCKVFDALPIAALIDETIVCIHGGLSPEVKTLEKLSSLDRAIEIPTKGALCDLVWSDPEVDKDGWELSPRGAGWVFGCGPTQQFLYSNDLSLICRSHQLVSEGFKSFWNDILCTVWSAPNYCYRCGNEAAILRLHSNGNKEVKYFDEAEDNERKKPDRIVAPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US67</accession>
    <name>A0A0N4US67_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4291</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000606">
        <property type="protein sequence ID" value="VDN54318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US67"/>
    <dbReference type="WBParaSite" id="DME_0001089901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001089901-mRNA-1"/>
        <property type="gene ID" value="DME_0001089901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160402" evidence="2">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="3">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001089901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26197" checksum="4791925F1ACF6FC1" modified="2015-12-09" version="1">MIIAAVTLALLCCVGQSYEQIYDPLCIQKGRKCGNNMVYRVIDEVKYADDVSPKVICIVECTCINEQYERKNGQCIEKNNITKRNEAEFGREILPKHCAGRVCALDEEIFNVPCSLTGKICGTNMIFTKIGKLLKKNGTEVCFQKCTCMSEEYVKANGQCILSTKGNETATPTSTQRSATESKLQPTMRKVRNLQLLFISHESTIFISCSILSFLLIFPNVILDEFKSFINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2I1</accession>
    <name>A0A158Q2I1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4494</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2I1"/>
    <dbReference type="STRING" id="318479.A0A158Q2I1"/>
    <dbReference type="WBParaSite" id="DME_0000013401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000013401-mRNA-1"/>
        <property type="gene ID" value="DME_0000013401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07087">
        <property type="entry name" value="ALDH_F3-13-14_CALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000013401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48178" checksum="6421788A6F58196A" modified="2016-06-08" version="1">MTSIHQIVEEQRNFFRTGITKKLEHRRQQLIALRTLVEKEERVLTEAVYKDLRRMPKITYGMELLSVFLEIDYMLDNLDKWTSPQVVEKTFLSLLDSLSIVKDPLGVVLIISAWNYPLYVVFLPLIAAIAAGNTAVIKTAERAPNTAKVLADLFSRHFDPHFLTVITGDAVVCANLLAERFDHIFFTGGQEIGKIILAAAAKNLTPVTLELGGKCPVVVESDADIEITARRIAWGKWTNCGQTCISPDYILTSQALKASLVEAIKKALSQFYSPNPKSSPDYNRLVDETHFDILYQWGEFDRDDLFMPPIILDSSKNDAIMEGEIFGPILPIVTVTGLDEAIEFINSKEKPLAAYLFTRNESKVRRFCSETSSGGVCINDVCIHLIVDTLPFGGVGYSGMGRYHGKFGFDTFTHEKSVVKRMFFGETLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2M7</accession>
    <name>A0A158Q2M7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4813</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2M7"/>
    <dbReference type="STRING" id="318479.A0A158Q2M7"/>
    <dbReference type="WBParaSite" id="DME_0000045301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000045301-mRNA-1"/>
        <property type="gene ID" value="DME_0000045301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="694"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="780"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000045301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1175" mass="132499" checksum="4FB2C1691549F72D" modified="2016-06-08" version="1">MKTKIIKISVLIKNRIIRSNYFRTKSKYGDTGNDRFTFTQALVFVQCIINALLAYILNGSYKDEVPQKTYAFLSLSYLLAMMASNHALQFISYPTQVLGKSCKPVPIMVFGFLFAGKRYNWKKYVFVLMIVIGVMLFVYKEQSPGKRIRPIFTIGFGEICLLFSLAMDGTTGAIQDNIRRFYKFSGHSMMYSMNLFSSCYLLVALLFTGELFSFLSFIYIYPFVMKNLLILGAVSAMGQYFIFKTISEFGPLTCSIITTTRKLFTMLLSIVIFGNVLNERQYLATLIVFTALFLDAVESKRKRIVAQTNDKNRDYYVEWKLNHGLRLIFAMNIDFRFTNLIGAVYRNGNITFTADGNSIISPTGNKITIFDLKTFHFLARFSCGDALYMNLGTHTVLYRHRFNRSVSDAKFSPNGRRVAVCRGGDLQIFSVAGFHTHQFNPFVLEETFHITADKINQIDWSGDSRLLATSSEDKQIRIVAGGNKLKNLYIYALASHKWEVIASYFVENSYNLVSIDRRGLANYWHCLSTAEDMIEGVRIKGSDDSNVVLTTYKKERKKNLMENIITDGIVNVSACCFHISTNILVIAFSNGVFVLYEMPTFTLIHNLRVSELKIHSLCINASGDWLGIACGQGIQGQLVVWEWQSETYVMKQQSHSEIISSVAFSPDGSLIATGGDDGKVKIWSCNSSFCLVTFTEHLSVASAVCWTPDGKVLLSASFDGTVRAHDLQRYRNFRTLICPQQTQLTSLATDSAGELIMSSSGDLYNIYVWSLENGKLLDILSGHTAPVAAIACNGNNLVSASWDKTLRLWNVVEASVAESIELIDEALDVAYSPTGQVIAVLCLDCSISLFDSSSFPLGTIDTRLDVDAARYSNDVIKKETSGKSKHFNCICFSADGELIVAGGQSNYICIYTVSERILVKKIKLTTNRSLDGVKLDVNRRNFSEFGNMELIDDSDSDQEDNFKKRIKLAGTKHSDLAERRSRPEMRVRSISFSPTGRCFAVCSTEGVSIYSLDHRLYFNPFELGVETTPKNIMKAIAAGEHTSSVSMALSLNENGLIEKALLATPISQLNVVVRSLPFTYIEKLLCWLGSECNQKVQRHINFWQLWLKNILFEYGRQLKSNRNSNLANLISIQQHISDYNKLVTTLYDQNKYTLRYLITVRQMRKTQQENITQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q304</accession>
    <name>A0A158Q304_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5698</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q304"/>
    <dbReference type="STRING" id="318479.A0A158Q304"/>
    <dbReference type="WBParaSite" id="DME_0000133801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000133801-mRNA-1"/>
        <property type="gene ID" value="DME_0000133801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097374">
        <property type="term" value="P:sensory neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000133801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="787" mass="89461" checksum="C886086195B42D3A" modified="2016-06-08" version="1">MASDCSTCFALDPQWKCSWCESNCKFLTECPSPQIVQSPDFLCSRPIIESFKPQVGPKEGGTVIEIRGKELGSSLSDVKDRVFVGSHRCAVINYEISTKIDCKVESGQGSGAIRLRLGQSGRRFVDSQSLYQFVDPQPKSIHPLFGPMSGGTKLTIYGSNLHIGSNVSVFIGAYRCEISPENNYDSAIMCRTSRSNEPRFAGPIRIEIDKSIRILERSFEYRHDPGNYLDSVLNPKIFFLSTSDTEEILSEMGRCHVQNATLMFCVTPRIILPPNISPLTYSRWPVGFLMDGVKSVRNLRERIQVTIVPDPQFEPLKGIKLHVPGQLFTVNGNHLSHAATADEYFIYIGTSRCTVVLIDNQQIMCRAPEHEPLATDAKGSEIEGGHPMLTIIIGSLKFELGLVEYETIGVRMPLRLLLTIIFVLIATCFLTGVILCFIYSKKRNEREKEYKKIQLKMEHLEFNVRNECKQAFAELQTDVSDAMTIDGDWIPFQEQTVFISHLLHHNITLSRSVLISAHHTPSDMFEAMRGFDSLLSNKRFLFLLIQSIENNPICSLNERSYFSSLIITSLMNDISYCTEVVFLLLNHHMNKCIRNRNAQLIFRQSSSVVEKIFAYWFSICLFDSMKSDLGQNLYLLYKALKYQIEKGPIDAINGNARYSLNEQKLLREPIDAATLHLLVIPLDGFNKSPILIRVLTCDTISQVKMKLLDILFKNEPFSSRMTIEQFDLEWNCQDGPIILHDKDRSKTNDPIRLNRVSDYNIPNNSLLSMQPNSSNFQEYNCKNFAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3H0</accession>
    <name>A0A158Q3H0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo/beta-catenin-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6734</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3H0"/>
    <dbReference type="STRING" id="318479.A0A158Q3H0"/>
    <dbReference type="WBParaSite" id="DME_0000237401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000237401-mRNA-1"/>
        <property type="gene ID" value="DME_0000237401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195736at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01869">
        <property type="entry name" value="BCATNINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000237401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="969" mass="107806" checksum="500B5DEF9237B006" modified="2016-06-08" version="1">MMASNGSFVLVDRFLTVDADMNNCPHDYVPQCSPVEPCITSTVAADARCLPIATVSPNSGLGRPSSQALQPSLISSRQVVSPQVIASQHVSSSQVPNYQPSPSSSSATIAPPPNGATNAMFRVQMWSNNFDSGVHSMNHSSAPSLISVSSLRAGSQISTMSDDAHSRMELTDQQQIKFENIPANIGRGSQDSEARNAIPELIHLLSDSDEIVVQRAATMVQNIAKMDSDQPPYTEPVIRASEVIPQLNELLRTHAKSPAIIKPTLGALFQISERRDGLESILKFIEQTNGALLIDIIQHIKFTGGSALRYAILTFHTIIAEKSSEGRNVEIARENAALQAVTQFLDRETNEKLLSVIVECVRLLCDKSQSQRTLFIQLHGPVKLLNILRNLRYEGLLWRTTQLLKTFSNADPQAVVVCGGYDVLYRQLDHASQRLIISTLECIRNMSDVPTKDIDVSALLNKLIQLLGAVDPIVVLYCTGILSNLLANNQKNKEFLYGRGAITTLYRVLINYCNTPAATPSQQQRIEDIQERALATLRHLCVGHSHQAEAQKVILHTEFAAEFLLRKLTEMRPSILKQTLQILNKAALQDSNLSILRSTRLRISPDCETTFIERIVLILKVACEQIPSTQMIEEIRVAELIQLSLSTLQLMCRDPHLLNQIVYMVRRQDYHLYKEGGESVPLPTFCLYQAYVEDENLKRSALGLISELALYPDMAALFSSDSSLMATFQHYSRSRNQAFATYAEQAYQRSLQGGNPAIHYHNYMNSAPMFRSTVATAPNQIPYNSSYPQAHQANYIPSNYSMTNPYIGDQLGHFPQQQQQPTMSTTPIACGGHECSSEESVQDISVQMSSSQSTPYLRENAQNCSTLDYSSSDFWPEDLSGLSINDDPFATIFCSPQFDSTQQRLSHQQIRPSYPSTDVKNQEAVAGNIYCNAGMQDYYYNQAMESIHMGSPEAPASWHDPSNTYRNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Q8</accession>
    <name>A0A158Q3Q8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosylphosphatidylinositol anchor attachment 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS187</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Q8"/>
    <dbReference type="STRING" id="318479.A0A158Q3Q8"/>
    <dbReference type="WBParaSite" id="DME_0000295801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000295801-mRNA-1"/>
        <property type="gene ID" value="DME_0000295801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000295801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="556" mass="63910" checksum="09916759AE5BB054" modified="2016-06-08" version="1">MRSLSESIGKRPWILIKIVDKWKEIGVLSILSCFLYVIFLMKFSEKTRISENALLPALVNENFQYSHHINAFVKHFHNNYNNRENRKYIENNLEMNGIKVQQQSFSLSLPFFNYSGINIIGTIRANRSPSVESILLAVPLEENSIEAMSTALALAIYCREQIYWARDVIFVFVDGNIYGMAAYLSAHHGTTLPFMKFDRIKYHSGSIVGAFVINATGSVFDTMDIKYNMINGQLPNLDLINLMVRLADKFSLTSTVFNHEYESEWLDAMKTLKNAVVTQAFINNEGIHSIFGLFGIQAVTIHLKNIVSAHANLHDLACICEGALRSLNNIIEKFHQSYFLYILPNCRHFISVAYYMPAIGLLLLPLIVRCLKEWFSIGQFALSNSYFWIHLIAFTNYIISSSLLASAHFYIYHHFSLFLLFVPYYLEEKYIESTRFIFLLEVSLILGSLSLLNFSLAFIISLIVVPVILFFSAFAAIKQLKRMKPIFGYFINPVILSIIFLLLFAEKKESLLNNLSVWINEFAQMHLLFGSIIYPILFVFLIPIWNILSQIFYACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3R2</accession>
    <name>A0A158Q3R2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7139</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3R2"/>
    <dbReference type="STRING" id="318479.A0A158Q3R2"/>
    <dbReference type="WBParaSite" id="DME_0000298001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000298001-mRNA-1"/>
        <property type="gene ID" value="DME_0000298001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000298001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27440" checksum="991332E9BE70B3D2" modified="2016-06-08" version="1">MNARSSVSKLTIEIRQIKETLLAIFAPLILQRTHGKIRYTAENIYQHGSVGFKEVLCDSIPFTYVCVNSNELNAKLQTEIDLFCSEVSSILNNTERVLHDSFSDSAKYEIVIPSAKIGLEFYQRQRRLLLPQDVPWEIWQMDLTVVRATDDGYLSSLADSLADELTSLHLNFISAINQSIYLPKVPSKSELLNVFDDSISDCNPYLYRIVRPQLSDGSRSSSYWQSAGGATVRRFLKDTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Z7</accession>
    <name>A0A158Q3Z7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS7692</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Z7"/>
    <dbReference type="STRING" id="318479.A0A158Q3Z7"/>
    <dbReference type="WBParaSite" id="DME_0000368701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000368701-mRNA-1"/>
        <property type="gene ID" value="DME_0000368701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000064">
        <property type="entry name" value="BR serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="369"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="475"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN57719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000368701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="745" mass="82846" checksum="D5CE90DBA7BAD2CA" modified="2016-06-08" version="1">MTGGGHVNLSTGVNVVSQQAQYCGPYKLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEHPHVLHLYDVYENKKYLYLLLEHVSGGELFDYLVRKGRLMAKEARKFFRQIISALDFCHAHNICHRDLKPENLLLDDRNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRNLLEKVKKGAFHVPSFIPVDCQNLLRGMIEVDPNKRLALADVFKHPWVAGNSKSEPELELPMSQVVQTHVIPSEENIDPDVFRHMTSLGCFKDKEKLVQELLSPRHNTEKMVYFLLLDRKRRRPANEDETEVVVRGTVHNLDPPRKRTDSSRTTRYAVGSISEGSPINPRKTYGRYNRGRHSSLSGSPNDSLRVRDAFTFSGPAPYARSSVEDRGRGASRNNNYHYYTQPVDSDALAAATRKVRTDFDEKNHQQRTGKQQSPNIMYNSILNSSSNESTTSSTSNLLGSSASGIGNLSGPWRSKLSNIKNSFLGTPRFHRRKMGSTGNCGENDDDGQIIDTTDLVKKSWFGSLTSSISVERDDVQCVPVQGKTLNGIKAELIRSFLTIHELSHSVIGQNSFRVEYKRGPTVGGSVFSRGVKMQVDIVVSPHAATSIGEAPMYVVQFTLLAGPVRRFKRLVNHLTAILQSSQQRADRAAALMVRPRRLSDSSVSSTCSDSDSTTGCTLPHVQSQTVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q484</accession>
    <name>A0A158Q484_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8107</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q484"/>
    <dbReference type="STRING" id="318479.A0A158Q484"/>
    <dbReference type="WBParaSite" id="DME_0000422401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000422401-mRNA-1"/>
        <property type="gene ID" value="DME_0000422401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013706">
        <property type="entry name" value="PDE1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08499">
        <property type="entry name" value="PDEase_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="96"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000422401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57594" checksum="3103D160615DA54C" modified="2016-06-08" version="1">MIVGDAYGFYQLILRKHACRLRYILHQLNSGQLPLEDLKHNLEYAALILEAAYIEENRQIYRRICDEDDDLAEVSPEEVPDEIREWLAATFTRQSAKREKPKFKSVANAIRTGIFFDKSEINKWSFDSFKLHEISQGHSLKYMGFELFTRYGFFERFKIPWQTLENFLLALEVGYSKHNNPYHNIYHAADVAQSSHFMMSQTGLANNLTDLELFAVIFAACIHDYEHTGHTNSFHIKSGSDFALLYNDRSVLENHHVSGTYRLLKDDDKNILARFSPDEYRELRNLVIEIVLATDMSTHFLQIKTMKNMLTLPDGIDKTKAICLIVHACDISHASKPWKLHKRWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVICGEMLMKMVEPLVSLPPFSMDANNQTAEGDNSNESVNLHFFSLFPNLFPYFKNFRKDSPALKLIRSLPLNYLGKLEIPDPWTAYMHENKANWKIQAAKGMKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4M1</accession>
    <name>A0A158Q4M1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8999</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4M1"/>
    <dbReference type="WBParaSite" id="DME_0000520001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000520001-mRNA-1"/>
        <property type="gene ID" value="DME_0000520001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857479at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000520001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39831" checksum="7F9C0C3E7A00BAC4" modified="2016-06-08" version="1">MEKFASDCLAAQTLANSVYFILLITVVAIISMIGIIVQIIIMKKYVICMAIHENTRILLVAHQIYLILHCVARIVAHTADLIVFHWNYHDPCMYLSTPLRCFIIRTPITFTFYSIPCSILVLTAERAIGTYQSAKYERMGRSLAYILIFIDIFLPAALVVFTLYGLDTFGTTKSRIYCSSVEKNNLKRGNFAAVILFLIEIGSVFLLRLLLHINMRIRQNRIEIDLSQRYQLKENITSITTIAPLILCHSIFYSIFLLAFIIYFVIKPAFSQDGFAIFLESGCSINASLFIIICVCAGLYGTTLPIADMCLKDFLRTCAISGTDLEGHRGIHWHAVSNKDKPSDWKYFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4N0</accession>
    <name>A0A158Q4N0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/ethanolamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9041</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4N0"/>
    <dbReference type="STRING" id="318479.A0A158Q4N0"/>
    <dbReference type="WBParaSite" id="DME_0000524201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000524201-mRNA-1"/>
        <property type="gene ID" value="DME_0000524201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3649325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05156">
        <property type="entry name" value="ChoK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF98">
        <property type="entry name" value="CHOLINE KINASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000524201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46768" checksum="237D8E30AADFC023" modified="2016-06-08" version="1">MKQILSELEPSIDANSIIELKERVNILCARFLGGAWKNISVQELIIQRLRGGMSNMLFLCKLPSKIVPIRNEPDKVLLRIYFNPETESHLVDESVIFTLLSERHLGPKLYGVFNGGRLEEYIPSRPLSCSEISMKQMSNKIARRIARIHCLELPIWKEPDYICDTMQRWLTQIMETPSGSHLFTVPDIYCPWAPKEVSCTQLGDEIEFLKCCINMTKSPCVFCHNDLQEGNILLLNTNYGNIRQSSIDDDFSSESSSNEFNLDDPHLVLIDFEYASYNYRGFDFANHFIEYTIDYSFNTYPFYEINNDNFPSIQQQIEFFESYIQESEPNLSSDEIRERALAMTEETLPFVAVSHLFWAIWSFLQVEVSPIDFGFAEYGLDRLGLYFANRKHLKNLLTNNNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4S1</accession>
    <name>A0A158Q4S1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HEAT repeat-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9284</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4S1"/>
    <dbReference type="STRING" id="318479.A0A158Q4S1"/>
    <dbReference type="WBParaSite" id="DME_0000554301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000554301-mRNA-1"/>
        <property type="gene ID" value="DME_0000554301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1241"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1660"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1719"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1660"/>
            <end position="1674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000554301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1739" mass="198790" checksum="A787FE0F30CFF66F" modified="2016-06-08" version="1">MAVERKLNRAERLASLLTSRNALIRKEAAEALSSFSLTNPQIPKLIRHYLQSVLWETRTAASTALTAILKSVPENSKQIEPSRNLLESLDLRAIVRDYHPLLSCELDLMTQLADCKLHDQRKILDEQLDFQTPIGVSSATFVSEDDFKNTNEVKFEKKFKLVLNADTDNIMICGDELDMAVQSICKEYLEDIVNMKWEIRHGAALAINSIISFAFNRLSAELIDLLTTKLFHVLALDNFIDFSSGRSAVGPVREAVSSCLSSLIIVFNSSSQFVNLIARNISLWFQRQAGLLILKYHFSGPCYFWKFDEFYGLITKCFDDTHDEICSSALSAITAVFCKGNLVREVSERLSKIEYILYHFIETACNTEKQQLLDIDTTIVDLLSLLQVWLSGNELRILPYSVSSNLSHLINPVHITRSNKIITVIATSFSRQQSVDYILKDNGVEFEECVIKVLSSIFRLVLFVAAQGTDDLIELCINCAAIITRQFFAIGRLPNALVETIGRWCSCLLLDAKDAEIDLVKYNVSVDKSNNGVQLLCGYEILTLNDMDRINALILRKLQISRFFAPLISTIYSFPSRIGDQSFNQAIQLLILPMLKSPLIMHRLAGSIIVYSWFTFNWLTGWNHDPPFLLITHIQQMVISGPATYVDEKFFFHYLENAYKEFVQYCRKKGVEQHRILEIEEHGESIDSNASKLFDISSAIIKEEHDRIVLNSRYEGFKDALARANAIMTANITRINALLVSSLLIVYPRVVLETPTLNPFIKPLMELLKFEESSYIANYILNSMSILFRMTSERCPSPHIKMIKQIVISLTSCLNRQAGWYIFALNFAYFSQLGFEKFFKEDSLLLSSKSIRSSSARSQNAEFVLRTLIAQSTISNFDFLLDFKNRESPMDVTMYMYAYSIYLDEIRKNRLSLPSDLDNLLIFLFRYFIYNFFAANDILVRFSAILCLKEMARLDGKLRKVLELIILPLQDSLRKGELSEFARAGLIELVYFLSELNVEILGALRILAPLSLRLMADKNEEIREISANAFRNLVPLMALKLVRSFKFFLFFITSYLNFYIHILSKLYEILEIRNDSKINLSSNDVADEGLCDCSIDLLLGDPSQLPSTAIEKIPGLKADVVLRHYQQEGICWMSFLEEMGLNGILADDMGLGKTLQTLCLLAVKLQNNPSTKVLIVCPPTLVNHWCYEWSVYFPTLTPLYKVDEGMKERQELIMKDGYQITVASYNTIRFYAYFQLEFFQLYINAFLIFFHISFFNIFSEFVLRYFREIEWYYVILDEGHVIRNPATQLFKAITSLHCRNRLILSGTPVQNTPADLWALFQFIMPGYLGSLKQFRISFLNSINACRSANASDKEIQDGQEALERLHKAVLPFVMRRLKMDVLDDLPEKIVQDYTCSMTDIQKEYYEHIVSLCYMGKDTGYREGLTALETISELRKCIVHPALVSPKALKSDCGVLLKIVEESGKLIALRELLRECGIGCQENDEDNDELSADINMNIRNRRALIFCQRLSTVRLICEFFNSDQLGMNIKYDVLDGSVPINHRHFVAENFNRDSSIEVLVLSTIGGEGLNLVGADVVIFVEHDWNPVKDLQAMDRVHRLGQKRTVNIYRLITEASIEQKIMRYQKFKTDTANALVGADNRSLKTMATEQLVELFAVEPSKMHNSTKSISSSSSQKPSKKKNRRNAQSDMDQKFDLEELWDQSQYDCFDVINLATSSTNYPQAAPSFISSDEPLNKKPRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4S8</accession>
    <name>A0A158Q4S8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS675</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4S8"/>
    <dbReference type="STRING" id="318479.A0A158Q4S8"/>
    <dbReference type="WBParaSite" id="DME_0000563001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000563001-mRNA-1"/>
        <property type="gene ID" value="DME_0000563001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="519"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="172"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="385"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="674"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000563001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1189" mass="138312" checksum="B1E2FE55C7F34F65" modified="2016-06-08" version="1">VNISGFRSYRETTVNDFSPRHNVVVGRNAIQFVLSDEFSHLRMEQRQGLIHEGTGERVTTASVEIVFDNSDHRIVAVEGNEVRVLRRVSLKKDQYFIDSKMVTRSDVANLMESAGFSRSNPYHIVKQGKINELATSPDSHRLKLLREVAGTRVYDERKEESMKILRETNAKSEKIEALLTYIEERLKTLEEEKEDLKEYQKWDKVKRSIEYMIYDNELKEARKKLDKLAEQREELNTRQGKVTNDLLTAQNRSLKASADQRRLEARFKGMREEKEALLSEQTERFQKKTELELLIKDLREDVEKERSGRNMAEDVLNKLKADIAAKEEEFKEIVPKYESLTEDAAKLNTDIRILDQRCKEFYAKQGYRDQYKTIEERDKALTKEIRFYDRQLTGIRDQIAEIKQNLEEEEQEEQQLHIKIMELDIHAEECVDRMSKLNQEMAELRRRLDQAIILQQEASRDEKNVRDNLEAIKIDVLQAEQDLRRLIPRFVMSGVDSVRKVLQHFRDNNHNGQYNSILNGYRGIVIDLFGCDSIYYQAVEVTTGNRLFYHVVDDDRIAMKIIKEVNAQKLMGEVNFFPLNRIIASQKRKTSDPDARPILDSLVYDEAYDVVFTHIFGGTAIVRNMLAGTRLAKKEGFDCVTFEGDQISRRGEMTGGYLDAKKSRMELHSTVCQLMEQKAIIEQALREATSKNNERTTTVEKIRMEGESLEQAVAALKDEHRTASEKKRYLSQQLQQIMKNKEPKMGQCVILKNRIREMEANKEGLQRQLETPLHSQLSEEEQAVLNNLQEEIKQKKVRLEIVNRERTDIELVKHRLENQLTTNLFRKRENLQAKIHDISVDEKRNNLQAEMAEMQLVNNRLTEIMTRLAELDRHLDEYERTQSELSRELEDCQEQQKDLEAQVTEFSKQVDLICTKQSAMQAKREDIMKKIKELGSLPMDAKQYESLPMKQLDRKLNEALEKLKKYENVNKKALDQYVQASSQKEDLTKRMEEHRANEKSINDLLAVLELRKYEAIQLTFKQVSKNFQVVFQKLVPGGEGRLIMRISDEDSEAAKDRTNLQQVEAFTGVGIKVSFSGSDETREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDAALDAQHRKAVADMIHELSENAQFITTTFRAELLDCAEKYFGVHFRNKVSHIDVVTKEQAYDFVEDDQTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5B0</accession>
    <name>A0A158Q5B0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9764</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5B0"/>
    <dbReference type="STRING" id="318479.A0A158Q5B0"/>
    <dbReference type="WBParaSite" id="DME_0000693201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000693201-mRNA-1"/>
        <property type="gene ID" value="DME_0000693201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="4">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000693201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="65690" checksum="6B9FE504767F8A86" modified="2016-06-08" version="1">MHNGGANILNMNIHDDLPSNLHAHHIYNHHHAHAHPSHPPPPPHHHHQQHHQQQQHHHAGPHQPSSNMNMTAAQQQQASLSEYYQSMAPAYQQQVHNNASQFMEADAPNSPYIGQAPQHMSAAAGQPPPPPPPSQHNHVIMRYRHVTPLGPAGPHQPPMGPQAQLEFRLHEMNRRLFIFSNSGIQEKDYAQWWDAYTHEFFDDDAKMNFLIFDDQNPSHHRFSIGRMLIPRYYRSIFESGVKEMFYVIRTPTREQVAAPWSMLLECDNILLVSKHDKPVPSEVHTECKLLCEFVFDETYGYRIRQWNIEFRHCQEFVIRDINMLQDSEMQEKLKISITRSGMTQITLNYLKLCAILEPMQILMSSSKSHNITPRETLKQTLFQAHAKLQQFQHQQQQQQQQMAMNSIGGMNGPHVMPQASIEEPISKKPRKRTRKAAAGNSANAGAKKKNSSPPAPNAPAFPISSHFPIQYQDVMVVGEPSMMGGEYGEEDERTISRVENTQFDPNALQNQIPSMNQPMSAASMPLGGPAPQVYLNDFELSSIGGWGSVGTTNQQSSSLPPSSTCVNTPIGNNNSVTSCGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5M6</accession>
    <name>A0A158Q5M6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1973</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5M6"/>
    <dbReference type="STRING" id="318479.A0A158Q5M6"/>
    <dbReference type="WBParaSite" id="DME_0000777601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000777601-mRNA-1"/>
        <property type="gene ID" value="DME_0000777601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000777601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="790" mass="88618" checksum="475293D49DB1E15D" modified="2016-06-08" version="1">MLHDLNQMMAASVANANQMANVISQSGIQSIPTTLANASLESNLSRPPVPRSIENLPPPTPNAAPPAPAPPKRREIYRYTASRPLFACAWSCKTHPEKRWRLAVGSIVEDKGGHNRVAIVQLDEQHGDLIERFSFEHTFPPNCIEWIPDLNNAFPDLIATSSDCLRIYRVENNNTATVECVLNNKQASNYSGPLTNFDWNDVDPTLIGTSSIDMSCTIWQIETGQSLSQTKKVTGNVKTQLIAHDKPVHDISFSKMGNGRDNFATVGADGSARLFDLRNLQHSTIVYEDPLRTPLMRLAWNKQDSHYLATFAQDSAEVIVIDVRMPCSPVARLHNHRGCVNGLAWAPHSSCHICTAGDDHQALIWDVSSMPRPVEDPILAYQAGGEVWLIKFIGLQHISTGFVFVLVEAWKYFEFNGFVVKDFKRSSIIIWSIFDLIGIDDHAMDSVFRKRKEIYKYEALYALFAMGWSVHPEKSKKFRVAVASFIEEYANKISVIQLDDEACELIHRGTFDHPYPPTKVMWIPDHKGVYPDLLATTGDYLRLWRLDGENGAKLEVRLNNNKSSQYCAPLTSCDWNEIDLSIIAVSSIDTTCTIWQIETGQAIGTTAAVTNGIVKTQLIAHEKEVCDVEFTRIGSGREVFASAGADGSIRIFDMRHLEHSTIIYEEPSRTPLLRLACNKQDSNYIAFIAQGSNEVPLIDVRIPNKAIAKLRNHHATVNGIAWSPYTPYHVCTAGDDNQALIWDMHYIMRPVEDPILAYQADGEINQVHWSAAFPEWIAICYDKYLEILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5V3</accession>
    <name>A0A158Q5V3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2388</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5V3"/>
    <dbReference type="WBParaSite" id="DME_0000838201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000838201-mRNA-1"/>
        <property type="gene ID" value="DME_0000838201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860250at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000838201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="46103" checksum="18B771A0741A1FBD" modified="2016-06-08" version="1">MMSLKDDSDLVDSVICKDVEIFYLLAKAFNDEYSIKAVHFVLTYLIGTLQNASESEQNQAQDLVPTLFSRLKKNFDHGSERLILCMDYVDLFQYSNHDSIYLLEEFMSTILFSLSIKEKMINEILEKCWKIRLKLGEKLKFNLLLLAEALIYNKIHIPLVYSSEYLLELCVSAFIRDVQVEMLGRHSIEIIQLCFIFCLTPIDDKTILRDALTKFVNKFQPFFDKILRIIEILPQDSLRKILMDLFRLTVNKFEEIAQLNNEASVLAWLLDEYRYFLRYNNYFQDELGYIWADLSAFRYKELEETSSYFISILLLMQYQALHRINKKLMLNVKEKILNHFHDHLCDFTSLINMSKVLNSENHLSLLQFTYQQTEIAVNEFLNDLPHNFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Z6</accession>
    <name>A0A158Q5Z6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell division protein kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mediator complex subunit cdk-8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mediator of RNA polymerase II transcription subunit cdk-8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DME_LOCUS2588</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24 26" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Z6"/>
    <dbReference type="STRING" id="318479.A0A158Q5Z6"/>
    <dbReference type="WBParaSite" id="DME_0000867301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000867301-mRNA-1"/>
        <property type="gene ID" value="DME_0000867301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000707">
        <property type="entry name" value="Cyclin dependent kinase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000088">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="64"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="VDN52615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="DME_0000867301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77524" checksum="23EB150229AED83A" modified="2016-06-08" version="1">MKNRKADGTPRTDAHTHTVYRSRSRFFVIWRIRRIYSLVCLLMIDYHFKEELIKTRERVEDLFSFEGSKVGRGTYGHVYKAQPRHPEQLPKNGAKEFALKLIEGQGFSMSACREIALLRELRHPNLIKLQRVFLTNERKVWLLLDYAEHDLWHIIKFHRAAKQKKQPVLVPKGMVKSLLYQILDGIHYLHSNWILHRDLKPANILVMGEGPGVERGRVKIADMGFARIFHSPLKPLAELDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHQDQLNRIFTVMGYPSESDWQDLKKMPEYQKLTQDFKRSNYANCTLQRYMDKHKIKADTRSFSLLQRLLTMDPIKRVTAQDAMDDPYFKEDPRPTADVFSGCDIPYPKREFLSDENDDKSSSASKTQAAPPPQQSQQAIPVHPQQQIMEPAAKKMRLQTNQMPPTQSQMEPMMNATGPLYGTSNAQEYPTVGSGPAVVNKGPMNFEQSQIVQPQHMNSTIPQIQYGQHQIINQTPTMYQQQPQMSMPQQQMTNSAQGQIQGRPMQIPAQSSMMPPSYQQQLMQPGIMGNQQMMAGPANTVMPQQNGMGGSGPLGGPQGQMTHQGPMMQQMRPQVQFVDQNGRVIPQSAGIMVGQSTQEIISQQGQYMMQQQQWPPMQPRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q672</accession>
    <name>A0A158Q672_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2981</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q672"/>
    <dbReference type="STRING" id="318479.A0A158Q672"/>
    <dbReference type="WBParaSite" id="DME_0000924401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000924401-mRNA-1"/>
        <property type="gene ID" value="DME_0000924401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="1">
        <location>
            <begin position="577"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000924401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134210" checksum="3ADC11202BB91850" modified="2016-06-08" version="1">MSSLSSVATDEDIVDRWIEIDDSISSPQQTLDEILAEKSINFEDELSLGDDDLFSIVTTGHILSTESDLSYQLDPPILKAKLVTGREVGTSDVNLLRKFRRSDLLNDRESERNIHRLDFPDLHRAFSEKVGRKAAARTYRLIISIESISHQLFAQYSRQNGGPASAIAVSDHCIAVGTSRGMVLLFSPTKLVIGFGSGALCIMSVATGKIVHEVFDAVQPGKGILQIIAVDRGHRLVILDNGGSVYELRLPSAIRSRQLRCIFSGSNGEVVFMNSLSKDRFIALFSLTKFFLISLPEVQCIFMLPYTGASNRPPLFDWRIIDSMLLGNKKILGPVFCIGRESRIDLFHLTNNSHGSKNVTHIRSFQLKYDIINLKWIDSYRFLTIDPMEKVHLFDIERKDIIEASMSISEMELIYATADFKGLSTGGNVSLAMQMLSDAVCYQSICREGSILYILGQFSVHTITLMDPLTQLDIFIERNEISSALLYATDLFASKVLNRSSRNDIQNSISALIPDLIKQLLVLTIDGLNFGKIVQLIDHYKKHIGLLVRTCVLTSQFDLLYNTIYPCLEKDPLSKSVFFEFLDELIIDGHFEDISPSMISDYLHYLMTEGHLNQFEAAVVRIPIDKLDIHYAMTICKANYLYDGIISIYNRALSDFIGPLEDMLIALESFIGLDGVLSDCETAQGNKLLLYLQCCLLGQAYPFGNLPYDLAKTLPLKVYSEDRLQKLILICHQITVCPNVEYSTYLLNFIAHLLKIKSIMAPLDIISELIRSILSNSICEAHTSETERSIIEMLSMVDGLDETVILNLAEKASFMQVCAYFYMKRRQFHNLIQCYIADERNSPSVFIVIENLLSELSQDEHSEFLRFIRSSIVVLTKIDSYRTAELILNYFIDLLNDEQITGNDEYSLLYNCFLMLLDLLRHWLPIGSRSDKCLNLAVTYDLTSSIILLLEARMLIDRAFEFVFAKFIKELIRLSSSYHLQSQKGQWLSKLLLKILTLPESRLTENGGFMMYINDIIASIIEGGSEETELIIDTLFNHPTFRHSTYGKYSSSIKCIIEICHYEMVLLQSIIKCIEQESNESIKKIAVESTCRCTELILSNKCIFCSQPLSKSSIAYRCGHIMHMDCQPDTNDRRCLCDHFNRRTDIFDRRMQLNSNSCSKINSVLNIFDDRSMKLKLGPSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P8V2</accession>
    <name>A0A3P7P8V2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P8V2"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="300" mass="34721" checksum="E43631399E80AF27" modified="2019-02-13" version="1">MQIFEAYKAGKVTNLVLDLHPQNTDFFAVDWIFFVDTINFSFWSEEGEKFEVTYKNQTYTGYFAACACVKRALDHGIPLLKADFMENITEDDIANIFRGDKGISIPLAKERLKVISEAGRVLNKKFHGSFSTCLEQCNRNALNLIKLIIDNFESYRDFAEYKTQKISFLKRAQILVSDLYGCFKGTGDLADFTNISMLTMFADYRVPQALAYLGVLKYSSDVFKKLQEHTLLENGSELEVQLRAFSIKACEMSKKYSNNNDALLEINTTNVDTFLWFFRRNYAKKIEEKVAFHRVRCIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PI34</accession>
    <name>A0A3P7PI34_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PI34"/>
    <dbReference type="STRING" id="318479.A0A3P7PI34"/>
    <dbReference type="OrthoDB" id="5914987at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13353" checksum="3F141EAF5E84113A" modified="2019-02-13" version="1">MKENQVFRPHVCKFQRFLATIVDLLPNARRNDELVQIIRIVGRQHCEIKTMSFTAEKWLAFKNVLSVLTENTGEVEFNFISHYFLTISLYFRFMNFVRLTNAHQTRILSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PS70</accession>
    <name>A0A3P7PS70_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mTERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000133">
        <property type="protein sequence ID" value="VDN53463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PS70"/>
    <dbReference type="STRING" id="318479.A0A3P7PS70"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39484" checksum="C9E636094F87D791" modified="2019-02-13" version="1">MKCILKFIVFYYFFQICSFERIVNRYRKILYTEGEIDGTDFSLPPSRSNPYPFDPSVDPTLLPPTHSRSLANYVNHVPLLQNLVDLGVSLFHIDTETNIGHNLLKLDWVKDVRVKLKWLMSIGIPAENLGIYITKNPYFLLQNLDDMKVRVNYLRSKKFKRQEIIKIILEYRFWINTAVRIIDARLGWIQKTFSLSGKEVRQLVIKEPRIIMNGIRMVEFFSKDLEFDGKEIKKMVLTDPRLFICDLSLVDQNYKFLHNSIGLSNGEIIKYPLALRCRLSSLKERFNFIKLLKETDNLPKNSSISLEKVLHPSDSYFTRNVVRTTLNSYNNFLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q4I6</accession>
    <name>A0A3P7Q4I6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q4I6"/>
    <dbReference type="STRING" id="318479.A0A3P7Q4I6"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="104"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="198"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="288"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="415" mass="45907" checksum="69B1A70BEFC93700" modified="2019-02-13" version="1">MPVITEHPLDVIVAKGEPATLNCAAKGPDIQILWFKDGEPVTTSKEEINSHRLVLSTGALFLLRVNNGKSGKDADSGVYYCVAKNKYGEARSREATLKIAMLKDDFRVRPRTLQAIIGNRAILECSPPRGFPDPVVSWRKDERELNPQDDPRITLHPGGNLIIDKVERSDSGFYQCIATNMVGEKISNPARLSVHEKPHFLQEPRDVTAEVGSSIMFDCRVSGDPVPSITWKKRNQQMPVGRAYIAADNKGLRIDRIQPSDEGEYLCQAKNPVGSIETSARLRVHSKPSFIKTPLDVSVEIGEVAKFECEGEGQPSPAIFWSREGQQDLLFPGHVSQDGRIKVDASGELTIVNVKPSDRGNYVCAIMNAAGSSLAKAALKINDASTVYKLFVEYLHSVEKKAEMLIDRKTRKRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q5S6</accession>
    <name>A0A3P7Q5S6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN59003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q5S6"/>
    <dbReference type="STRING" id="318479.A0A3P7Q5S6"/>
    <dbReference type="OrthoDB" id="5815677at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="1165" mass="135077" checksum="B7CF9B916678B1CA" modified="2019-02-13" version="1">MINISIMTDKSDLLRRSKRKKFYLNVAAMLSANSERKRNQHISSIRATTDYQSAAINEQSTTTTAASATTTTTIHRVNSQLKKRRKRRRKSMKIEKETIENLQKFDSKNLKMNNKSLSRLMNNKLSSPIIGSIEIAPTISSIIAKLAKENNDMKCLIKPNAETISTTSSTTTTSTNSSSISPIISSSPNHQINHSSETNPIISQPSLVNDHHSSVNVSVVSSYIESFLHVNKVDKRSKKITKKSISKKTSALKSDSIVKRIGKIKLKRKFAINGKIGMVHLQNGRLDEIKDENIEKSPEEEISNEELAITVKDKIDKDRIEAEFEWVKDEKEICGTEIVTGEKIGENQAEKEREIAIGIEKEEGTETEDGTDREEDFVKKNRISEKLTKKRERKAPLRHGDYIPDEEIDPPQKEHRKEIGEKFYCASCPASYTSRTGLANHRKQHGSDKEFVCKECDFSCKNQKTLRVHELVHVPPIVEITTNAATLVKPLISSPHQTEQSNTIREEALNLNLSESKDNNDNEVKKDATIDNRKEPSEFVKRLRNELNNNDFHQRTIKRIKKKFMKRLRDKYPKYINIRYGRCFSTIGQYYLNYVLHRKEFKRSQSLLNVWQKYTNHNETETEKHKEEITEDVISEPLKPRNGNHRCSHCPYTTDKKSRLARHENKHIVQAEHKITSVGNRRISVLVSIEIIEIVMVSFLLLSCEDFAEMAHGSSFFKCNFRLCPYKCNTYAKSYRHNKKHQKRSRYICEQCTFSVGSAYRLEEHKALHATDPSTSNDKYENMQSACNHQIVAKKDEAQIDENTSQNLPFTESVDGADDGDDDVLGERPKSRLDYHQPTFLLPPPPRPFLFSTKEEYECVHCPFSTDCEKIYEIHKSLHDGQNRHFSCHICTFSCNMPVNLYDHLTLHFMDYGFAFGKLCSADNERQRHPTSSDIKMDPIQSFMRYFITNDNSVNEELQCKICSFRTADRKLFYIHQYKHSSAIQRRLMTKIKREPLTVDGTQRKYKRKADPYSKKYCCSICSFYCDTITIFNLHYEMHGRNGIYTCHLCNYSDNTAVRVRFHEENHHHKESLMHFLKDAVFRPEISRVKNINDLLEGNHLIKESCQEIKCNICSYKTYSVLEFSNHWSNVHEKFDRTATREELQRCQEFHMNIFPANSVIFKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QGP8</accession>
    <name>A0A3P7QGP8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QGP8"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018037994" description="NADH-ubiquinone oxidoreductase chain 1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22303" checksum="140188C43A67383C" modified="2019-02-13" version="1">MVVVVLFDFYTLVCVLAELNRAPLDFSQGIACGFNVEYSRAPFVFRASFSVCADCIFVFSFCSFCDCFLFGSWVVSVSFLVVCVSDYISGGGVGGYFVKCLLVLIMLVIAFSFYHCSGCTEDKFVYVCELIVCLGGFCLVKFIIMLELFWLCYYVYMNFLIGQRGKWALLIVRFGTIIIDILFNMRGRIIRILVLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QSK3</accession>
    <name>A0A3P7QSK3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QSK3"/>
    <dbReference type="STRING" id="318479.A0A3P7QSK3"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="249" mass="30010" checksum="6B394450FC3499C0" modified="2019-02-13" version="1">MKGETKPYETRFKKNLEEEWVAPVPLPPMPKDFKEYPERDLVNYPFPARFMYAPKTRMLMFPDSWFTAFYNITGISGIFGILCIFFINIQLWNQKLKCSNFQVLTFSFLALMPFYQLNNYLFRKVTAKHEKYKKLMADELADCQKKKKDVIDTVESIKLIKENFPSIFEENMAIQLEAAYRKNVEMVNMEMKRRLDYLRETQETKKRFAKEHMLKWIIDSVTFANLFKLIFIFQAFNQKLLQFRRFSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SL82</accession>
    <name>A0A3P7SL82_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-binding serum glycoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SL82"/>
    <dbReference type="STRING" id="318479.A0A3P7SL82"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF134">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="176" mass="19655" checksum="6F38C26BBDC2EFA2" modified="2019-02-13" version="1">MGELLRTTCSPDEVCLSDSVPEVGEKYPNRQLEVILRTTVTPQVKLSNGTATIRLEGRAFFFLEGTSIKVGKIPFETIATFFFSTIHDRLTGSMAISKLIFKKDVDFFDLPVDSLNGLRDATKGATLNLLNTLLKKGLPLNKTKDLQISEPLINIVHGAFIIQVNFDLERDFYNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SR89</accession>
    <name>A0A3P7SR89_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SR89"/>
    <dbReference type="STRING" id="318479.A0A3P7SR89"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053341">
        <property type="entry name" value="Oxidative_stress_globin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768:SF1">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768">
        <property type="entry name" value="GLOBIN RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="160" mass="19294" checksum="D11A5D6C71D3B3A8" modified="2019-02-13" version="1">MMRTWSDDFEYLYQLGSNIYTYIFQTNPKAKQLFPFMEKYGDRWKESKEFRSQALKFVQVLSLAVKNVYHMERLAPLLYNIGEKHVQFIDRGFIPEFWDTFLDAMEISLEAHIKSLNDFNEKQRNDAIRTWRTLALYIITHMKFGFIDGLETRRKSKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ST11</accession>
    <name>A0A3P7ST11_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ST11"/>
    <dbReference type="STRING" id="318479.A0A3P7ST11"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="533" mass="60756" checksum="E18F1B988C8164FC" modified="2019-02-13" version="1">MTLAIDDRCWSNRGSCCEIIPEISRLCTAETRELRLAPLFITLLYDDARWVVRAAFENLGPFIATFADTGQICSTRSPAFDDCKFLYLPFFCRKMFHESAAAVCTTHTDLSKLFVEEDVDGFQFMFEEELNIPKELIESYVKIASSCSSIDISYLCAHNFPAIAYTIGRENWPHIKEAYIHLSTDVQCRVRLSLASSIHEVAAIIGEENSAKYLVPAFEMFMKDIEDVRLVLLNHLYDFFKVCLFLSLKLDFNLLTTLATFLHSTTGNDINWRFRHEYASQCILLCDLYDVYDLNKYLSGIALTLANDKVADVRKMGTILLASILGKFVQEEWCLDSSSVSTDESPIPITESFVNDIIKAFARSMTVVNVRIAFARALAGTRGGRAFHGSRDSTLVRKCLETLTSDIDADCRYVARISLGIGDGETIIDVGFQFFIYIAISFHCSMPKYNLAVNFLFSSIFFSFFYNSWVRFRLKIAVNEYDKGKIPFLGLKKLTKKFPLFEMSILTAEFTSRIGSPFYIVNFILYFRKILFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TCA6</accession>
    <name>A0A3P7TCA6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TCA6"/>
    <dbReference type="STRING" id="318479.A0A3P7TCA6"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="161" mass="19104" checksum="0DF6C3744DECCD2A" modified="2019-02-13" version="1">MLEKSIIRPGFEKILGEGFVPLSAGAAKRMRKIERERTKGVSWFNMPATELTEERRRDLELLQMRDTIDEKARYRKSDHSTLPKFFQVGTIIESKADFYSSRIPKKARKRTIAEELLADIEFQARQKKKFNEIKSLEAIKKKGSFRHSWYPKKKRMRRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0D0</accession>
    <name>A0A0N4U0D0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4364</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0D0"/>
    <dbReference type="STRING" id="318479.A0A0N4U0D0"/>
    <dbReference type="WBParaSite" id="DME_0000000401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000000401-mRNA-1"/>
        <property type="gene ID" value="DME_0000000401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17711">
        <property type="entry name" value="BRCT_PAXIP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="415"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="527"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000000401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="662" mass="74711" checksum="8BFF91C3C028C0A0" modified="2016-06-08" version="2">MLTISVWIPSVYSTATNSAQQSGVQTQQYSPARYPTTVQGTAGISPCYPQGQAQIISPTQAPTIASQPPSSSMGPAVVPNAASIPRMEVPGGGGAIAPQHVRIIPQSAPFFGHANAVLNSYILVQGDMCLIGCFFIVIEHERILVDRLDVQEIGAVVRLHGGEIEFGPRAYNSVNSERVTHIICESMRHHLVQQALKERKRCITLQWLNDVVAKKRLEVPWRVSHLPSLWAENHRPAAGKIIAIRGFCENERSGIKLMINAIGARYTPYLTRHNHFLITKSNDSEIIEKCREYGVTVVNYQWLVDIYLGLKNVVNENENCYFPMPNMVSEVNVSPYALEHFSDLCKQLLAPWRSPIIFTNEQWQRANEIKRNVENDENIFPNKKLRCSTPPPTEEDIAMNLGEIEKLEEIPVVCFTGFTSEEMDALGRKIRFLGGKITDSVMECTHLVALNLWRTMKLLQAIALGKNVVGPNWITDGYRYRTIPGLLFFFTKHFLCQFSDTMDYFMRDDENEKCFGYNLKYSILRARCRKIFQDVMFYLTPSVEPSYSALSSLIILAGGKVLEDKPQPQFVIRCIEVLLPFNTDSPLLLISNESDIHLLQYLMDSALPVFNVEIVLTGILRQKLENSPLYRVPVTRPSTFTPSPSQNSRSKTPQITMQRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M7</accession>
    <name>A0A0N4U0M7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4473</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0M7"/>
    <dbReference type="WBParaSite" id="DME_0000011301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011301-mRNA-1"/>
        <property type="gene ID" value="DME_0000011301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846344at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="7098" checksum="E2478F232BD089CF" modified="2015-12-09" version="1">MAKDFFYHFRKRFSLYIAPFTVLSIILLDWNHTREWKKNDRKSLLLELIKDTHRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U152</accession>
    <name>A0A0N4U152_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4674</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U152"/>
    <dbReference type="STRING" id="318479.A0A0N4U152"/>
    <dbReference type="WBParaSite" id="DME_0000031401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000031401-mRNA-1"/>
        <property type="gene ID" value="DME_0000031401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000031401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17401" checksum="870BA0F1E108DA41" modified="2015-12-09" version="1">MHVTRAIRRKRRESMAIRRESRATRLVAAILTSSFDIKSNVQKSGRCQRKLPHPVCNYWSKANQIQKNIAFLICWIPYFCVSVYRGICAGLGTNTDKQLHIRLFAVTSWLGYAHSCFNPVIYTCLNKNFRRTVRKFFASSRWRRSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1I4</accession>
    <name>A0A0N4U1I4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4829</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1I4"/>
    <dbReference type="STRING" id="318479.A0A0N4U1I4"/>
    <dbReference type="WBParaSite" id="DME_0000046901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000046901-mRNA-1"/>
        <property type="gene ID" value="DME_0000046901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="193"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="281"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000046901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46781" checksum="790D4DF58B179FF3" modified="2016-06-08" version="2">MSELTENRGQIQRGQHALRRRDFNERNIQQEGKVRFEKVETQLLQRPPLHETGQSSFAIFCDNALKSEKENSNKTPEFVSEINKLEQSDDEEMDVDGSSTGSTHSHENDENFDPGTLDVGSRKRGEIMVFDHCPPYPAPIINEDSTGHRMIFHKDYEMDCFQYMRFLESKHTFSSEMLQGKDFSLRKRRCSFDWMVQVSSEYNFAPDTIHLAIAIFDRVLMAYPVNNVAIIAFAAAAILIASKMEEIYSLGTDLIAQLTNDLVVRAERYILISIDYRLDIATSFWFAHFLNHRMEMSENFICLTYYLLELSAMFVEYLDHRPSVLAISSIVLARLCIMKDEDPWPSSLESFGITFDEVKKGLSFMRAVFQQGPHMDYRGIYNKYSKRQFFSVATSYVAPNIDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1P5</accession>
    <name>A0A0N4U1P5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4899</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1P5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1P5"/>
    <dbReference type="WBParaSite" id="DME_0000053901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000053901-mRNA-1"/>
        <property type="gene ID" value="DME_0000053901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821563at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720328" evidence="2">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000053901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26246" checksum="A470E219D91C71D6" modified="2015-12-09" version="1">MCFHQRRALLLFAIFNSLRFVSYKFEMMRLNSFGECSVRKELPGLYMNGVLSIPLLSRLVSCGYEHGFYQDVKNLFVALLALFSYLIVITISAIDMTFGPLYAFRIFRYPIVYPYFNFPLVLFGLHHFVLRTHRDFKRDVFEVIDEDMFLYICRYQCLNLCECAQKLKIYKMTTIRPSILARNGRINIAVNIHTIDNLNSLDENLKSKLNLKSQFDEKNIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U240</accession>
    <name>A0A0N4U240_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5075</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U240"/>
    <dbReference type="STRING" id="318479.A0A0N4U240"/>
    <dbReference type="WBParaSite" id="DME_0000071501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000071501-mRNA-1"/>
        <property type="gene ID" value="DME_0000071501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001598">
        <property type="entry name" value="ABC transporter ced-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF271">
        <property type="entry name" value="ABC TRANSPORTER CED-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041081750" evidence="8">
        <location>
            <begin position="18"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="526"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1224"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000071501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1579" mass="178985" checksum="65D64D62F6419C2A" modified="2016-06-08" version="2">MFLKLLLLLLRKNIVTAWRGKAWIFAEIFLPLLLMVPYTYFGFEKPAIVPAETFESFRVTGDWRDFKRHVGRLSTIYKTLCLRSKYIGIAFSNGTGNEKELRFIADKLEKRYNNEMLGDFNITVRIFDTSKTLDAELVKDNATCGKYMGGIVFSEFNSRLSYKIRLSSPFGSWYTGNEIWKYGDPFTILNDHNPVPGTPSYWSSGFLSLQFARGNSTFGQNYILRLERMPEPEHFDKSINFFLSLLVFFWFLALIPFVIHSTAKVVAEKESGMMAYLMVMGLRPSVYFTSHFIFALVEVFLILIPPCIILLFGLILISWSLFIIAILIYGIGLVSFVMLMSTMFHSSTTALKASLLIWFLSIGLPFYIQSIFQSFNAYFYYNVIELELELLNRDLAILYSTNYGIFLHSLNINAAFYRAIEAVQNYLQRDTYLGWENCFDGSSSPFPFGLSLIMMIIDIIWMILLASYLSQVYPPGEIPAKSFFFFLPFCKKEEMTLEKMDDSTDRMNVSNENIQIDERGIELADIDIRNLTKKYSTLKAVDALSFKAYRGNVTVLLGHNGAGKSTTFSMITGVSKPTSGIVRICREVLSSSSLTHCQKNVGYCPQYNPIFDLLTVREHLEFFRKLKNNRDNFIDSLINEVGLGDKANEIAKNLSGGMKRKLCVAMSLIGGSQIVLLDEPTAGMDLGSRHMIRDLLERYKCDRTILLTTHYMDEADALGDRIAIMVKGKLVCSGTSEFLKARFGTGYLLAVDLKDPTNITNRRDSIMKAVQCFVNSARIQSASAHQLTILLPTEHKKKVGEFANQDAINYDGIDFAKRHASKLCNHSHYFENHMVLFLVQIFALIRKRAVCYIRKPSRLISQFFIPLLLFIMTSFAMKTTVYTLNEVKLNPDKLVPSVVLLQFDRKLPLLENSFTNFLNGIKGYETRYANLQANLSEIILQTPKVLPPLALVFSTSLEGDHIKIVAFFNGKAIHGPVIAMSLVHNVLLSKEAGPITLSLLPYEQEKRSTIFVSENGQSVIVYWISIFILSLISSGFISFLVDERSSKFLYQCFSVMLLWLLYFWSVMPFTYCASLLFLNSTKAYAAVMSLNLVVSLGALLIVQGLSLYNPSLIGYIDSPLLILLPSYAYLNALISLVEAEFAEVENIYQWKLLGRTITFMCISGVAYWFLLAASQSRRFCLFLASIWNMNFHRNTITEGFIEEDVDVMTEREHMERTANCELALAVRGISKYYGRFCAVNNLTFGVRPDECFGLLGVNGAGKTSTFDILTGTSFCSNGKAFLNGHSFNGNQRIGFCPQFDALLDYLTAKEILQLMASLCGFTDVNQRVQSVLEAVHLIPQANNIVRCYSGGQKRRLSLGIALISQARLILLDEPTAGIDPKARRQIWDVLTAMRDKGCAILLTSHSMDECEALCSRIGIMHHGSLMAIGSPQHIKSRFLFSFKFSLVFLRFGEGYTLTVTLKSKAGKDDVIQSVKRLFPESSFKTLTHPLHLVWHIGRRDGDSKWFFQNLFFVLFFNLAAFRWSVFFEKADHLASMHSCIADYSFAQATLEEAFLRLSQQGDDHIERVERHVLPLSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Q2</accession>
    <name>A0A0N4U2Q2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5332</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Q2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Q2"/>
    <dbReference type="WBParaSite" id="DME_0000097201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000097201-mRNA-1"/>
        <property type="gene ID" value="DME_0000097201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="260"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000097201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="63641" checksum="7828AA4623D76166" modified="2015-12-09" version="1">MRSKLTRTELIKPVSSSVCYCDGKRELGSLELFCAICRKCYGLSFMVCYVFNCGDCSPTKSETWTPKQANFVHMCVTVLANLTYNVIKDKEDAIRDGVLVNPIFFNIESEIIPYFNAQWENLTSMTRRVKNTWHQTLLRALTKETDLFETSEDGQSFALRERDLLSIGPAHEPLKQIGKSKGSGNISHRECKDQERIDESSDGPKTRGSKRRNAEGGLNALKKAKYTADYASTRISGMAVPIDFPFNREGYRYYLVEKDMSVPNREVFEQEDIYGKPIPAHTYRITTHPTVTLSPNDRAFQLKLSDDRLSVTGFEGYCVARATHHISHGTYYYEVVFVSQPPGSHVRIGWSQAVAPVQACLGYNQFSYSWRSLKGTVFHQAKGKHYASGGFKEGDVLGCLISLPSCPSDPNYDCMSVNSLPQSSSYLFPSHKDLPLINFKHNYFYEEKDEIQNLIKDLKVASGSYMDFLIRLQIEFFLNGISCGIAFRDIYAGFYFPAVSLFQSATVKCNFGPDFYFSLPDGAKAMCERVEEMQIEQTISDVLFLVENEKRLAEEARNYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2T9</accession>
    <name>A0A0N4U2T9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5375</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2T9"/>
    <dbReference type="WBParaSite" id="DME_0000101501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000101501-mRNA-1"/>
        <property type="gene ID" value="DME_0000101501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10638136at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000101501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30496" checksum="234F8C968E71E902" modified="2015-12-09" version="1">MEAKCDFAEAMIYSKEFKVSSIIRLVLAVIGVFLAIILIRNRNNFVRLHANAKLIMLSYLVWTLLMAVSAGIVNATNVLRFMNVTFATGSAECVYLISAKIAYPIRTFAVFCGFGDALTMISFMIERSIAFFACGTYEKKSSRKLAFCLIIFEIIGSVVSACGPNIWQTNWEDMRIFIQSRTSTSERSSDFSKILKFTTATACNSECRYKILFQFIPVLHIIYILVALIGLHALLVMNNICIQQSKKIFNFGSSATAALKLGEKYQLIVGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U372</accession>
    <name>A0A0N4U372_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyanocobalamin reductase (cyanide-eliminating)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5526</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MMACHC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U372"/>
    <dbReference type="STRING" id="318479.A0A0N4U372"/>
    <dbReference type="WBParaSite" id="DME_0000116601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000116601-mRNA-1"/>
        <property type="gene ID" value="DME_0000116601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033787">
        <property type="term" value="F:cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12959">
        <property type="entry name" value="MMACHC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032037">
        <property type="entry name" value="MMACHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457:SF2">
        <property type="entry name" value="CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457">
        <property type="entry name" value="METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16690">
        <property type="entry name" value="MMACHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000116601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24916" checksum="FD60D57710E95E5D" modified="2015-12-09" version="1">MAVLFITAPSFFEVTFKKWLQKKWKILGNFEELKEHFGSSPLQLFFSEQFEQLRKVFIHFIKFIFSIVIHDFDLFPNRRPKILMTVCGHAAGAAYFYRPDDENFTNNSGEQMKRMMGLSLHPKYGGHFAFRAVFIFPHLRLTESFKEKSPPKCLQTAEEQQQAIRLFNESWKDGRFRDCGSPVEKYSDLQLAYFALPPPERWSLIAHWFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3A4</accession>
    <name>A0A0N4U3A4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5563</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3A4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3A4"/>
    <dbReference type="WBParaSite" id="DME_0000120301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000120301-mRNA-1"/>
        <property type="gene ID" value="DME_0000120301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF32">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000120301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25910" checksum="053CDCEF737AC56A" modified="2015-12-09" version="1">MLAMHQKDRTHSIITIPELIENEETARDIEGLKADIELTDISNAVARRAPEKGINVSVRVVDKAIVHREDLEVASVVYMIIFGSSANNFIDGMSNGVAFGKSLFRGLSIGIACIAQQFPQELGMLAILTKTGLGMKRTLLLNLIPGFLSYFGFMIGATLGRSFDRSDQFVFAVSSGMYLYVLLGTLIPEMRESTNELIKEDIKKSLIATLEQIIGLVVGVLFMLFMALYGEFIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3V6</accession>
    <name>A0A0N4U3V6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3V6"/>
    <dbReference type="WBParaSite" id="DME_0000142501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000142501-mRNA-1"/>
        <property type="gene ID" value="DME_0000142501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000142501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="23715" checksum="0144877DACEAA997" modified="2015-12-09" version="1">MSDSPIFRARSSVCLPRSRSVERFGDVATLTRVSSVPNLQVIHVGDRYQPSTLFKYRRDWDLLDDYWHDKIFFETPVYWQDYRFAARRYINTDPIPQSLGFEYPAFWSRYKWYTDWLNPTYWRRYRDPNYDRPLWNNWQPWHLDRINVKRAIRMFREGLISFKTLDKSWIEPAALGRKGKDWADIYLPAGQEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U421</accession>
    <name>A0A0N4U421_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tumor susceptibility gene 101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5864</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U421"/>
    <dbReference type="STRING" id="318479.A0A0N4U421"/>
    <dbReference type="WBParaSite" id="DME_0000150401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000150401-mRNA-1"/>
        <property type="gene ID" value="DME_0000150401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000150401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43314" checksum="C993B725369CEBAC" modified="2015-12-09" version="1">MTTDSLVASLLHRTKAKYIESAKSDIIIALNSFPDLSPEAENFVFPDGHRRLSFRLKGTIPVFYKGNTYNIPVALYLWDTHPYYAPICFVCPTSTMMIKESKTVDKQGRIYLPYLTDWRFPGYDLSGLLQVMACYFQESCPVFAKPTSGAGAPSQPQQPYTPYPLSNQSSQQPYIPYSTSSAPGMPANPLTNSQLPNFSNYPSLFSNAASQSSHLSGTIQPEHLKASLLSAVEDKIRKRLREKLGTIHAEIASIRQTHSDLRAGQQELKKIKDQLVNEQKNLDEILNIYKNKKAEIDSVISSFNDDADLDIDSVINACTPLHRQLLRCYVQDCAIDDAIYFLGQGLKSGRLTLPNYLKEVRQLSRKQFIHRATLLKCRIKAKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4E2</accession>
    <name>A0A0N4U4E2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6006</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4E2"/>
    <dbReference type="STRING" id="318479.A0A0N4U4E2"/>
    <dbReference type="WBParaSite" id="DME_0000164601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000164601-mRNA-1"/>
        <property type="gene ID" value="DME_0000164601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000164601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27498" checksum="7B3CC480745F25A0" modified="2015-12-09" version="1">MMSASKARWHCIYLIIASFVFNSWILFIADINEYGVCDILPEYEFIYKIMNTVETVFCMGLPSSVILISNLLVVFRLRAHLKRIPSSPTVSFNTTELVMNSALGTKPSNSRATFCRVSLVKINHAQSLSVDGQEKRKKFLRYTDIQLTRSLLVVTWAFIVLNLPNYIYRIIAKVLVVDTQTLAMRQMSLFVHTLLYTHHAILFYLYIFYSPQMKKRLLPTALKLLECYCLKPPLNDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4I3</accession>
    <name>A0A0N4U4I3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6056</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4I3"/>
    <dbReference type="WBParaSite" id="DME_0000169601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000169601-mRNA-1"/>
        <property type="gene ID" value="DME_0000169601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000169601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8297" checksum="44A0E22176324364" modified="2015-12-09" version="1">MRINEGPINEEVDNAVVAIHQPRLFSRSLVEEILLHFIKIDLGSKSAGVTTLSEVSWISPGILLYHPSVFIGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4W4</accession>
    <name>A0A0N4U4W4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Protein kinase C</fullName>
            <ecNumber evidence="2 16">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">DME_LOCUS6213</name>
    </gene>
    <organism evidence="27 29">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26 28" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 30">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="20">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 16"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4W4"/>
    <dbReference type="STRING" id="318479.A0A0N4U4W4"/>
    <dbReference type="WBParaSite" id="DME_0000185301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000185301-mRNA-1"/>
        <property type="gene ID" value="DME_0000185301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20833">
        <property type="entry name" value="C1_cPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="159"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="299"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="558"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="305"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="VDN56240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="WBParaSite" id="DME_0000185301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="628" mass="72353" checksum="2037A5D1E9FB2379" modified="2016-06-08" version="2">MIFLLFFTNFTIKNTIEGKRFVRKGALRQKNIHEIKSHKFIARFFKQPTFCSHCKDFLWGLNKQGFQCQVCTLVVHKRCHGFVGFQCPGADKGVDTDDPRQQHKWKVQTYSSPTFCDHCGSLLYGLIHQGKRCQSCNMNVHHRCVKNIPNMCGTDHTEKRGRIHLNIRAENDILKIHEARNLIPMDPNGLSDPYCKLKLIPDDQSSKSKQKSKKIRATLNPVWDEHFLYKLEPDDIDRRLSVEVWDWDRTSRNDFMGSLSFGISELMKEPVEGWFKLLNATNKSSMWKKQKDTIKATDFNFLSVLGKGSFGKVLLGEHKVTKELFAIKILKKDIIVQDDDVECTMTEKRVLALPDKSPFLVTLHSCFQTMDRLYFVMEFIGGGDLMYQIQQVGKFKEPVAVFYAAETAIGLFFLHSKGVIYRDLKLDNVMLDCTGHIKITDFGMCKDGIFGGATTKTFCGTPDYIAPEIILYQPYNKAVDWWAYGVLLFEMLAGQPPFDGEDEDELFTAITELNVSYPKSMSKESVSICKGLLQKNPEKRLGSGATEEQDIKEHAFFRRIDWFKMENRQVQPPYKPRLKSPSDVSHFDTEFTQEAPHLTPIDRLFLMNLDQNEFEGFSFTNPDYVQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4X1</accession>
    <name>A0A0N4U4X1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6220</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4X1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4X1"/>
    <dbReference type="WBParaSite" id="DME_0000186001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000186001-mRNA-1"/>
        <property type="gene ID" value="DME_0000186001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000186001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24409" checksum="215F2F5F70327D9C" modified="2015-12-09" version="1">HTGVNQLGGVFVNGRPLPDSTRQKIVDLAHQGARPCDISRILQVSNGCVSKILCRYYESGTIRPRAIGGSKPRVATVNVCDKIESYKREQPSIFAWEIRDKLLNEKVCTPDTIPSKCADFSDFALDTHSSYTPKIVSSINRVLRNLAAKKEQQAMQNDFYDRALRYSTTQWYSQWPMNMPAAVGLTPFQPIGQPNHIDKKDLGRLDFDIDELCCQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5N1</accession>
    <name>A0A0N4U5N1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6526</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5N1"/>
    <dbReference type="WBParaSite" id="DME_0000216601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000216601-mRNA-1"/>
        <property type="gene ID" value="DME_0000216601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863152at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229862" evidence="2">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000216601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12529" checksum="A19B392F4207F5DC" modified="2015-12-09" version="1">MIAPLIFFIFADIIASNPFPLQSNLSNCDFCKDVVGELEFSLKNDMQSIEKLISDFCDLITASKPRFDPLCKSLLDKTIEELIDVLIDYVKPETICVGIKVCKRNEFFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6C2</accession>
    <name>A0A0N4U6C2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH-type with G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS6823</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6C2"/>
    <dbReference type="STRING" id="318479.A0A0N4U6C2"/>
    <dbReference type="WBParaSite" id="DME_0000246301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000246301-mRNA-1"/>
        <property type="gene ID" value="DME_0000246301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20384">
        <property type="entry name" value="Tudor_ZGPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF1">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="15">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN56850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000246301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52111" checksum="C20BB3AF64AE4E5F" modified="2015-12-09" version="1">MDGTTELTTYKQQLDDVDNELMNCDNLERRNELLTARADLVELIDLLSENLDEDTANNAHQLSSFYNESDQSNGNNQSENAFNEECEISADEIIGMNCRAPYKRIVDKAIHLHDAIILELINNGDCSLKVKILYCYPLELAMKPCEYFLNDRCSYGENCKYSHGEEVMFSDLLEYVPPDFSNLVEDSLVLVQVENGLWCSGRVTAVDDENLAVKLLSTGKEVATLRSKVLPLPEFSKDSSLDLEVSEQSSSSSSWQELKGETKGRVTIGDLGDWEKHTRGIGMKLLLKMGYRVGEGLGRNSDGIVHAIQPVIFPKNKSVDICMESKKKVIDGLNQKRDCVKRAIAKKLAESAANNNVFALINKLNPETQKVLDHEDKQLKASSSKCLGIHSLNIDKEIKELKIKERKLHEGIARNMRDRTTAERLKRNLAHCQQEIAKLKKRQQRLANEIDNRRYKKDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Y5</accession>
    <name>A0A0N4U6Y5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7079</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Y5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Y5"/>
    <dbReference type="WBParaSite" id="DME_0000271901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000271901-mRNA-1"/>
        <property type="gene ID" value="DME_0000271901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF73">
        <property type="entry name" value="LD06050P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000271901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65465" checksum="01DC883E12F212F5" modified="2015-12-09" version="1">MELSEAIELQRIDDVYLIRGPRRPQIGSLALIGHHLIFSPLSAPSATKSNSHHPDELWLLHRAVDRVTVENLSKENPSKGGSLILKCKNFMICIFEINNIDSCMAVARSIGKLSNLSGIQHEYPFYYRCPFTVLDNGWTAFDTEQEYAKLMIRCQEGWRISSVNAKYRVLFLFLHSCSLLEKLFYPETPGIGDDYLRISATFRDGGRFPVLSYYHHETKSCIMRCGQPLIGPANRRCKEDESILNAVLSSTSKGIILDTRSKQIASSSKNKGGGCEPQVYYSQWKYVNSAVPRIKEIRDALSKLMELCDDSPQSVDRWLSKLGSCGWLQAVADTLTSAATVAQCIHCGKNLEVPVVVHGGEGTDSTLLVTSISQLLLDSDARTIRGFQSLIEREWISAGHPFQLRCAHSAYASGSVTGPYESPVFLLFLDCIWQVYQQFPCSFEFTEEFLIFLFEHAYASEFGSFLGNNEKDKQQFEIKIRTCSLWSYVNNPEILRGYVNALYEPNQSVLWPSVAPQSIVLWERLYLRWQRDWKQMDGVKQTIMQWKNKEKELQSKVLVLRRQIIELSKSINVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U816</accession>
    <name>A0A0N4U816_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U816"/>
    <dbReference type="WBParaSite" id="DME_0000316101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000316101-mRNA-1"/>
        <property type="gene ID" value="DME_0000316101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042245" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000316101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8492" checksum="C31D25289FB32FBA" modified="2015-12-09" version="1">MLRVLIKWVWSTVGAIRITLMEPEIRMVLNMVPTRAMVPEYTVKKSPLSRTSRVSEIKSDEWAAGLFLRIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U858</accession>
    <name>A0A0N4U858_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7366</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U858"/>
    <dbReference type="WBParaSite" id="DME_0000320701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000320701-mRNA-1"/>
        <property type="gene ID" value="DME_0000320701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232698" evidence="2">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000320701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23449" checksum="7BAE7B7BB48634B0" modified="2015-12-09" version="1">MLFQFCVVICLIHNAKGTDDEKIGECNKQVGMVQRPTVNPNLCAHLDVDACAAIFEYMGVAAGIMIGGAEQFRSVDYYVPKKCTDGALKNFAQKSCPYRCAFCCKAKQFNSFTWDMCKNPLLKTIALMRCPQKCGLSAGMCINALGDEVCNALRNSCQKTCGIKTCLGTQNATSAQPPCRDEQRCSDYRQICRVEPYASIMRTKCRLTCGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8P5</accession>
    <name>A0A0N4U8P5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS296</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8P5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8P5"/>
    <dbReference type="WBParaSite" id="DME_0000343001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000343001-mRNA-1"/>
        <property type="gene ID" value="DME_0000343001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="544"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000343001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="694" mass="77865" checksum="9E63E60678E61E44" modified="2015-12-09" version="1">MPYELKPPAWSLLQNIVPNSFSNGLSPHIVVIFSILLRLEGYAELLVTFDRQRAKRLLRLAMGVSTSEHRSFARFTTVHQKIAPKSNACDFMKISRADADFLALLPLIVLEMLFNSHPSNTSRGKSIRDSALTYGVLDVLLVCLAHYGHQKVESFSARSEKLPPVPYAVVLTERLLQASVHTEGANVESTSMNQLPYEDRFIVDYSAASSGTSYPQSQNFWAKGTGFGSGTTQQQWNVDLHVLRRKFDENTVTLLLKVNISYPFRHKLDRIHLKYIFFIDHALFVILFHIQVLMEFVNPFPRPPKNSLVHSNQAIDVQETEDKPSLSRINDEPEVGFEINGSSGWVADGVIVDLLSHSDIFNDIFLVLDISRHVEVYQAVVDLVGALAVAPVIVDNANSNILSALLSKSGCNLSLHSMLKQLQACISTYLNRLSSGKNLKQTKLTDVDENCNNDNSVLKCSEEKLIALATTAQSTCDLISQKLVDDSKEVDGAENKITTIEEQYIKIMRSIQFDTVPFFAEDHLVPYHYHSSLQTVSVDNALNLRTRRLAQEFVTLSNSLPLSSSSCVFVRSAEERLDVVKVLITGPADTPYMNGCFEFDVWFPCDYPNSPVHINLETTGNNTVRFNPNLYNDGKVCLSVLNTWHGRPEERWNPETSNLLQVIVSIQSLILVSDPYFNEPGYERSRCTQTGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U921</accession>
    <name>A0A0N4U921_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7568</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U921"/>
    <dbReference type="WBParaSite" id="DME_0000356301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000356301-mRNA-1"/>
        <property type="gene ID" value="DME_0000356301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000356301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10418" checksum="11DCEFBDB1798078" modified="2015-12-09" version="1">METVTQIGDNRKLFCLIHKATVTQSEGVSEMIRDINGVPIKAVKDRLRRRKEFFEAKHNYDAPSVVPNTIDLPIEPYFCNCEPPTEEEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9F0</accession>
    <name>A0A0N4U9F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS7713</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9F0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9F0"/>
    <dbReference type="WBParaSite" id="DME_0000370801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000370801-mRNA-1"/>
        <property type="gene ID" value="DME_0000370801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000078">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="354"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN57740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000370801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52987" checksum="2720FC33AA6D3324" modified="2015-12-09" version="1">MEIWFHFSFQHNNFLFFYLNNAELVREAFQEAFETIKRLQYKAWCKANEEDKKTIEIDPFLITRKAVKNCTPLLKLCPVTRGGVTYQVPSPLSEKEAEFRAIQTMRNIIRSKCRRGADHFPKLLAAEILAAYNNEGFTIQAKQEHHKLCEANRAYAHYHQKMSSTILSDFEQQYSVQTAEITARIGRLQHLNKTEQITGIKDVQCLLMEVENLLEQMEIAVHELDPSRFHMMPSPLSEKEAEFRAIQTMWNIIRSKCRRGADHFPKLLAAEILAAYNNEGFTIQAKQEHHNVERSKYDLRVKSYRNDKKQLDAELNKAVQRLRNTVDRDELLAYDSEITLNQVSNFSIKFKQDHLIENTERLERTSRRLQDTYRLVLETEQIGTEVLEDLNSQRETLSRSRDRMRQANTDIGRSQKVLSQMIRRLIQNRLLLLIIAIFLLFSLVFLIYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAN2</accession>
    <name>A0A0N4UAN2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8104</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAN2"/>
    <dbReference type="STRING" id="318479.A0A0N4UAN2"/>
    <dbReference type="WBParaSite" id="DME_0000422101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000422101-mRNA-1"/>
        <property type="gene ID" value="DME_0000422101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039175" evidence="3">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="136"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000422101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23136" checksum="C23A949E5070581E" modified="2015-12-09" version="1">MWMIFNIIYFFFLTACATYDETVTYSSVIKLKNIQEGVRLHSHDIKYGSGSGQQSVTGMIDLDDVNSHWQILAAMNASYKRGQTVKCGDLIRLKHTSTGCFLHSHLFSAPLSNGNQEISCFTEGDTGDHWVVVCNTDEWLRDGSVKLKHKDTGKYLATSGHQYSRPISGQREVVGVSSPGNSALWRSMEGIYMLPKQQQYRHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB03</accession>
    <name>A0A0N4UB03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmodium vivax Vir protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB03"/>
    <dbReference type="WBParaSite" id="DME_0000436201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000436201-mRNA-1"/>
        <property type="gene ID" value="DME_0000436201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000436201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9547" checksum="CF8C5034397C9643" modified="2015-12-09" version="1">MQDLEESLEKQFTVEGRCSNYNGECEKDRNNTCIDEPVSNIFGIKHFIKKCCSSAELSNDSISVMNWKTLFSIIPFITFMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB76</accession>
    <name>A0A0N4UB76_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8323</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB76"/>
    <dbReference type="STRING" id="318479.A0A0N4UB76"/>
    <dbReference type="WBParaSite" id="DME_0000444001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000444001-mRNA-1"/>
        <property type="gene ID" value="DME_0000444001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013288">
        <property type="entry name" value="Cyt_c_oxidase_su4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01873">
        <property type="entry name" value="CYTCOXIDASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000444001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22248" checksum="21658E7215B38EA1" modified="2015-12-09" version="1">MNLSRTLLYSRLSPNLAFLRTFQTTSKLFSGHEPEYYWAPIKAGNREVVGFGVNGDPAYLDRLDYWYPAIRFREDDDVIRPIREKEKGDWKNLTIEEKKLLYRYSFKQTLAEFEAPSGYWKLIVGILLSVMALATLYATFLNHFVLQGPPPTLKNEYKEAVLRKKLILEKGQFLGPASYYDYERNRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBE2</accession>
    <name>A0A0N4UBE2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8401</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBE2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBE2"/>
    <dbReference type="WBParaSite" id="DME_0000451801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000451801-mRNA-1"/>
        <property type="gene ID" value="DME_0000451801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000451801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36794" checksum="D76E2D662A907B0C" modified="2015-12-09" version="1">MRGEDLKCMTEEEYTKLMIFFTNLIYAIALDPQQGQKIRIQVIATACVYFRRFYARRSLKDIDPFLLAPTTIFLASKVEEHGMMSHNKLIQATNSALKRWPFIPQDLVIRVQNIQEAEFILLEIMDCCLMVYHPYRVIFRPLNQLMADMSREYKDLDAISTYAWKICNDYTRTDLSLLYPPHLIAIGDACILIASIWTNRDKELKNWFAELAVDFDKIFEIQKVILNMYSIWKTFDEKEQLLPILQKMPRPNPGPQNTNSLVQQHSHNSLTMNSMGVHQSVSMGPPQMPSGKMISVGLSSINKVNEFELKLWKGNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBJ2</accession>
    <name>A0A0N4UBJ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8456</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBJ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBJ2"/>
    <dbReference type="WBParaSite" id="DME_0000457301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000457301-mRNA-1"/>
        <property type="gene ID" value="DME_0000457301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000457301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24140" checksum="7A52BBFE8A3052CD" modified="2015-12-09" version="1">MFDHRGADQFLTSFDVSEDTGSVLTAALPRMSAGAGAKKAKFDHHCVSNFSAGILSPQTRTQVLSAINFVNNPFIRDSYASETIFNGGLMATASTSVDTIISQRPSKVVHLRNIPSDMTELELIQFCMPYGKLMNYLILKGKNQAFVEYEEQQGAQALVAFSLAFPVAIRDRTIFCQFSNHQELKTEKRSLVPQNEFDTDTEVGYSVLMFLFSASNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBS1</accession>
    <name>A0A0N4UBS1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8556</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBS1"/>
    <dbReference type="WBParaSite" id="DME_0000467301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000467301-mRNA-1"/>
        <property type="gene ID" value="DME_0000467301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000467301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="22527" checksum="7F024D17AD5A7CF1" modified="2015-12-09" version="1">MKSTNRRSNNSNLINQAVIPSTSNAAQPQPQQQPIQPKTTQVIFLQKNPKLFVSKNGETLQQILLTQPTTTLAVSVSDANLRNHLAVGGGGSGGSGGNGGSTTTDSLVDSVNSTDLFQQQQVSNDEGTSSVTYVTNTNGLTSTDNSFINNDTSVTNDTTNNHGTAVGSGNSTTVGGSINGRNDNQQQITNMDIYSIPQQHINTVYIIIICTIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC54</accession>
    <name>A0A0N4UC54_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8714</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC54"/>
    <dbReference type="WBParaSite" id="DME_0000483101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000483101-mRNA-1"/>
        <property type="gene ID" value="DME_0000483101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000483101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="43218" checksum="4D22EC3C1ABCCC83" modified="2015-12-09" version="1">MLENDGWNMEKYNSKFVKKQEKINLFNETKFIGKNSDERKIKKDEKKANQTFITKSEILNETNSDNNKNATIIETTDKRFDKFESATMDEKRNEISQNFHFIETNETINLFKNNNNSENQKNIAYGVVLQKIPLISKMETLKTLKNRDEKISELFSELKKFLNQAKGSDELRALLDNNKNSKKSLFERLKDEIQRRNNRRNEWETTTNNEKIITEFIHDDYSFMKELDEEITNELIKSLNEITKKKNDKVIKKCDNNLKKTKDLPMKEILLSELSENITKEAIRTNNFNNNSKNSNFSRRLESTEKLPKSIKLEEIVKNSFKIPADIIQKEQNYYFADRLQSAMVNLNNLINIANDEIIKVLNKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCA7</accession>
    <name>A0A0N4UCA7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">tRNA-synt_1g domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS513</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCA7"/>
    <dbReference type="STRING" id="318479.A0A0N4UCA7"/>
    <dbReference type="WBParaSite" id="DME_0000489201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000489201-mRNA-1"/>
        <property type="gene ID" value="DME_0000489201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="7">
        <location>
            <begin position="161"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000489201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48658" checksum="8A0A621A3A1D091C" modified="2015-12-09" version="1">MYIYHRFLTFISRRMRHFFVTTPIFYVNAPPHLGHLYTALIADASYRWNLFECGGTCLFVSGTDEHGTKVYKAAKNANVDVKSYCDRISKTFVDLLDRFNIHPTNFVRTTDKTHQLAVQYVWKNGLLSKKIHQGWYSIIDECFYNEEDVEELINNNNSSKISKITRSPVEWVQEENYVFTLSQFLEPIKKWLMRDGTIYPKNYVHPALLCLNEVNEVSVSRDSNRVLWGIGVPDDDSQNIYVWLDALISYLSVTGFPNKKNIYWPPSCQFIGKDILRFHVKLWPAVLMALNLDLPKRIFVHGHWLINNIKLRFSIMMSKSLGNVVDPIAAAGDLTFEGLRYFLLRQGTPNDRANFDILTAKRVVMSDLSNNIGNLLQRSTVKKMNPKQAYPSFDQAILAYKFTDGLIFIRKLNMLHGIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCB1</accession>
    <name>A0A0N4UCB1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS517</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCB1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCB1"/>
    <dbReference type="WBParaSite" id="DME_0000489601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000489601-mRNA-1"/>
        <property type="gene ID" value="DME_0000489601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000489601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23815" checksum="91AA7F1D4553560A" modified="2015-12-09" version="1">MSENLCFAVRASDALSLFRGTNSPTSIFQTTANNGKSCRISRFSNTGQYFAYCDGVKTVVIEIATAEEAISVDLPRTQKIVFSTKDHIMITYEPHVTYGPRVNGIEGRQRKPPPNMRIWTLPDGRLLAAVTAQNVNSGKMDWSDDESCALRVIGSELMIGKSIFSEKYHSKLAVPKIDDFALSRGSEPYHCAIHIRAFGGQPALTQIRKYNFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCM1</accession>
    <name>A0A0N4UCM1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IER family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCM1"/>
    <dbReference type="WBParaSite" id="DME_0000502101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000502101-mRNA-1"/>
        <property type="gene ID" value="DME_0000502101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5822441at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008653">
        <property type="entry name" value="IER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15895">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05760">
        <property type="entry name" value="IER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000502101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34848" checksum="80472694CE287A09" modified="2015-12-09" version="1">MYTGEDDIDGPLETNRLIQVSCEKIVNSRNERGGAKLHRNLMIVHLIRKARSHTMRSAVGYPYPSCAEANSFVYGSPSSDIYQNSSDCQSNPSCYSGQLRNASEHLYNAYNSSHYGHSEFSMELSDEMDYAIPLEPIKLRFVGNEVPMESGELLELKQSEVPKNGSLLYGEQQTEISSVQMSSLPHFGDELQQSTSYLSENIEEVRELPAAEDDNGCFVDDGDDEETEECQLSETSGRRKRKTSMTCLAASDSSSAKKCCVEEHQLTGLISVFNSGLTVVADQILPRTPAANLLPPASDQIVPSLMHLACSPLICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD51</accession>
    <name>A0A0N4UD51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9034</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD51"/>
    <dbReference type="WBParaSite" id="DME_0000523501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000523501-mRNA-1"/>
        <property type="gene ID" value="DME_0000523501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000523501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7445" checksum="982B7C2128CA72D7" modified="2015-12-09" version="1">MNSMNRASDYAYTSHNISVPTEEGIQTHYAAHNLDDFGFIECHSSGSNSSQGSSSGFESMKVCFVFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDJ2</accession>
    <name>A0A0N4UDJ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal_L23eN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9206</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDJ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDJ2"/>
    <dbReference type="WBParaSite" id="DME_0000540701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000540701-mRNA-1"/>
        <property type="gene ID" value="DME_0000540701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000540701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16473" checksum="75BC969969523356" modified="2015-12-09" version="1">MKAAKVAKALEAKKKVVKGQFNTRKKKVRTSVHFYRPRTLRKPRTPKYPRKSVPKRNKMDSYAIIKHPLTTESAMKKIEDTNTLVFIVDVHANKPQIKAAVKKLYNIDVHKVNTLITPNHVKKAYVRLAADYDALDIANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDU0</accession>
    <name>A0A0N4UDU0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9256</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDU0"/>
    <dbReference type="STRING" id="318479.A0A0N4UDU0"/>
    <dbReference type="WBParaSite" id="DME_0000551501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000551501-mRNA-1"/>
        <property type="gene ID" value="DME_0000551501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15720">
        <property type="entry name" value="FYVE_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21387">
        <property type="entry name" value="GAT_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03569">
        <property type="entry name" value="VHS_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024641">
        <property type="entry name" value="HRS_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12210">
        <property type="entry name" value="Hrs_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000551501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56207" checksum="09CCEA3D6147CCE4" modified="2015-12-09" version="1">MSKKFDRQLDKATDSTLIDPNWEAILECVNLIRSGEALKNAVASIRKRYHNENPHVAHHALLVLEACMKNCGSKFHAEVATKDFMEDLKNLSLDSTPDKVKNKILELLQCWAVVFKNKPEYKIVVDTHNLMKLAGFDFPKISEADAMFVAESAPEWVNGDECFRCRTAFGLITRKHHCRACGQIFCDKCSSKQSYLPQFGIEKEVRVCDGCFDKTPSGKKKLPIDASTPSKNNSVSDPKKLAEIRERELEQAEEDEINLAIALSQSEAEAKVLAFIILANNHRQVSHRIYLHRLMHSFYVTIMDNRIRSNTARNRSIVNDTAIQSLFIRLTEMHAQVMARMNKLEDQRTYFESLQDHLAHIQEARQAVNALREEHERQKQERALEEQRNRQRQMQQKVDLMRQKKHEMLFHQRHLALLRFQQQEQEIKMKRMQIQQNAQPVRPNGISSFVQNDTEPQPFNSTGYYQTTQPFYVDSANNGPYVAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE25</accession>
    <name>A0A0N4UE25_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRKG1_interact domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS650</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE25"/>
    <dbReference type="WBParaSite" id="DME_0000560501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000560501-mRNA-1"/>
        <property type="gene ID" value="DME_0000560501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000560501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10912" checksum="BDEBFFE96544FEB2" modified="2015-12-09" version="1">MCSMPLFRQHYSGASPKLTSSLTTIPPCDPEPSESNDRVRELQSLRYANKSLTQSIYDFQKLLQEKSEQIASMESTNAKTVAKLEKEKVALSKEAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD8</accession>
    <name>A0A0N4UFD8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9439</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD8"/>
    <dbReference type="WBParaSite" id="DME_0000614301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000614301-mRNA-1"/>
        <property type="gene ID" value="DME_0000614301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000614301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8067" checksum="08E3F4F200127CA6" modified="2015-12-09" version="1">MPDLKSQVAAKYLAKRQIAAAMTKCQIRSQIAAKYLAKKQITAAMTIRNQVAAKYLAKRQIAAAMTIRSQISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG46</accession>
    <name>A0A0N4UG46_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9556</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG46"/>
    <dbReference type="STRING" id="318479.A0A0N4UG46"/>
    <dbReference type="WBParaSite" id="DME_0000644501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000644501-mRNA-1"/>
        <property type="gene ID" value="DME_0000644501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000644501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26164" checksum="8C478324CACA2405" modified="2015-12-09" version="1">YCIYEHLIKETCLARNYHCNYYNLINSIHFNRISVADHELLHPLASAYCLDENVASDITSLNEQCSVVSDEQDDQNAVVCGHAFAAGEIAYSCTECASDPTCVFCQDCFQNSEHKYHKYRMSASSGNGYCDCGDEEAWHRNPLCNLHVVQQSKETLGQCPESFNAILFNDETHTYDSVIRALNLSIHCDDSQAMRLATIVDREGRAVVCSDSHEQCQRVKEEIQASFQNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG95</accession>
    <name>A0A0N4UG95_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9611</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG95"/>
    <dbReference type="STRING" id="318479.A0A0N4UG95"/>
    <dbReference type="WBParaSite" id="DME_0000650001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000650001-mRNA-1"/>
        <property type="gene ID" value="DME_0000650001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818107at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000650001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38914" checksum="2FC089BFF9B35033" modified="2015-12-09" version="1">MMRHVFQLRELILMMNIEEDRNAAIEVYVLRFYYSEKGENFVLYDNDRKILVALEYKGDVHLPKQIAFLLRRITDVTSTMECLPERTLPLLKLTYYSNTPDDYEPEGFKRCKHTYHFKDAFGEGILGQITAKFCSCTVEVKSIFIDDQRLSMQNLHLFKRNNRGNVADYASDWNKTERARDADQSSLISDDVVHIHSISKANGDKIERASILFSSDSTKSSPKTDVLMSEFKVGRLKIHRAEQKKEMDTIKKSREAEVMEKEKLYRKFFHESEQMNDSSSHLATFGSSTLNLLNPTWSFIASDSGDGGYMRDFSIRLPTIFKWNLRADSTKIYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGK9</accession>
    <name>A0A0N4UGK9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1278</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGK9"/>
    <dbReference type="WBParaSite" id="DME_0000663401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000663401-mRNA-1"/>
        <property type="gene ID" value="DME_0000663401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841990at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052322">
        <property type="entry name" value="Mito_rRNA_Mtase_NSUN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955:SF5">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955">
        <property type="entry name" value="PROTEIN CBG01349-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000663401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32119" checksum="9A7ADB47880CD442" modified="2015-12-09" version="1">MVLDEAWNKTTLLHGHGGVRPLHIIALILGIINCMLNGTICFFTIPTMANLFAHNNLNCPRWTIIIGSGFEIGLDRMRKYLSIAVAVERLVALYWPQRYYTANHSHIMQYVFKIGLIWSILDALAMISEDDLNKDNEKTNLLSFQIRVHCVTTSSSGRMFHTYYLLSSLIFSFILLVLYSLLIIKLCFLKITHFNYVRNMRSVKNYKNYKQANSLAVLIILSVISFSAVPSALYCYDLVLGQIVFMEWGPVVTIGCHLYGCTSFFFYNWQHKEIQTAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGM9</accession>
    <name>A0A0N4UGM9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein CLP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9681</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGM9"/>
    <dbReference type="STRING" id="318479.A0A0N4UGM9"/>
    <dbReference type="WBParaSite" id="DME_0000665501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000665501-mRNA-1"/>
        <property type="gene ID" value="DME_0000665501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.330:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000454">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="124"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="7">
        <location>
            <begin position="317"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000665501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="47570" checksum="BC26AA21811F1E1F" modified="2016-06-08" version="2">ESSAYIIGFNIEIINIKYLVAFKVASKGNVTLELVDGSAEVFGTPLVLHKKYSFSHGARIAVFTWKDAVIELVGETESAYIAGETPMVIYLNTHAALEQLRDHAESGCASQSKDPRGPILMVVGPTDVGKTTLCRILCNYAVRSGRTTTFVDLDIGQGSISIPGTIGALPIEKVADIVEGFDRQYPVVYHFGSVTPSANIVHYDLLVKTLAEEVFKRMNAHAGVKYGGIIINTCGWVKGEGYACIVHAAEQFEVDVVIVLDHERLFIELQRDLPNFVKILHQPKSGGVENRSREMRISARNAAVHKYFYGSRALPYYPHTFELSFDEVSICKVGAQQIPAECLPFGMKIDDLKTRVITVEPSDVLTHHIAAVVNSTKSDQSVLTANVFGFIVITSVDLTRKFYTVLSPQPHPLPSNILLLSDVTFLDDKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH20</accession>
    <name>A0A0N4UH20_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RB_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1428</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH20"/>
    <dbReference type="STRING" id="318479.A0A0N4UH20"/>
    <dbReference type="WBParaSite" id="DME_0000681401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000681401-mRNA-1"/>
        <property type="gene ID" value="DME_0000681401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013584at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000681401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="51918" checksum="57E14AA4EA96415E" modified="2015-12-09" version="1">MKNTKDFDDFKKSHIIENPSNSKKNNEAAESCHNQNAAVKIGQECFLSSMQNSNKAYEKLKLPYVLNGSSDIHSPYMQLQPTETQAHYLMELAKRLLTEAGGSQTTAIFNASQNMSLSNNNTHSGPHRLLHICSFLIGLYALAVNNMVSPSWQTRTYSANVSSAAIKTIERVWEVLLTPTEVVALADKASQCRDPATVEAAAKLALSVLPKAYSLSASEIHRALNQCKEQNSEMLEKACIAIEEAASKDGVYPEVLFKVARYWYELFCECEPVVSTTSFSSANSNPTVTTVATLLHPIISSSPVSFHNDILLSLFGQPYQNILPHASIVNSAQRPRMPPPPMPTSTHQSSFIVHTTSVSQQQPFISFFSRTRPRSSIPIASTFDETMKSPRPVPTSYPPPRPSLPLSAVSALHNTPRSLHISHSAPDLDPVQLITRKSMHNYRWNEIGKDQLNIDQVPNFLCFKSSGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH45</accession>
    <name>A0A0N4UH45_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1460</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH45"/>
    <dbReference type="STRING" id="318479.A0A0N4UH45"/>
    <dbReference type="WBParaSite" id="DME_0000684601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000684601-mRNA-1"/>
        <property type="gene ID" value="DME_0000684601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF898">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="335"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="161"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000684601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56813" checksum="2FAC29CC012F5CE4" modified="2015-12-09" version="1">MAVQIKINYATNILLLFIISNDYLYAQFALPRADETVVRRNKRDINEGIEEARALLKGFLKLSADVPLTPQRRSNFGSKRINYKVMDRTEYHANRKILDEVFETDLILTVPQRIKRTKRKAIIGESFRWPNQVIPYILKENDSEWKKLILSGMKKWETETCIRFKQRSAEKDYVHIFKGAGCYSSVGRIGGKQYTSIGFGCGSEGIVAHELGHTIGFWHEQSRPDRDKYININEDHLISGTKGNFERRDDILDLSTTYDYGSVMHYGPQAFTDDYNFLTIETKDHRFQHTIDRCRKKLDCLHGGYENPRNCAVCKCPSGLSGTRCESIPHSTGKCGGELTASQIWQTLKSKTVGKCFWRITSTTGKVRLEVLDASYVCDSSCSDNYLEIKHKKNLEQTGFRQCCNGAPGIILSETNRVYIISISIKNPSYFTLRYITDSLLTPVPKPPPDRWNGGGITALIGAENGIDNSWEHFILKQLPDVLKKIGRPSNNPWSTIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH97</accession>
    <name>A0A0N4UH97_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1522</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH97"/>
    <dbReference type="WBParaSite" id="DME_0000690801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000690801-mRNA-1"/>
        <property type="gene ID" value="DME_0000690801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799464at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229918" evidence="1">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000690801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16500" checksum="CACB484E04F6802F" modified="2015-12-09" version="1">MFIVAELSIFFIALLTNVESASTNLPHRNPKFPPPEFKGILPAKDFSRLEAIDADQNMPWQEKHKQIDAIMSSLPDSVLDRLPLPAGFEKLPQNIQEKLRAAHKAKNITWDQRHAIIHNIVESLGKEHKRLIHPPPPPRGFVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHQ1</accession>
    <name>A0A0N4UHQ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1619</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHQ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UHQ1"/>
    <dbReference type="WBParaSite" id="DME_0000709301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000709301-mRNA-1"/>
        <property type="gene ID" value="DME_0000709301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5827518at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000709301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13213" checksum="4D6105BF0494D67C" modified="2016-06-08" version="2">MQSFQEKSRRDQTIFSQSAKKDSNQALNNKFDHPKTVARSVNSLILSKPLLIHPHTGPTFNCKILQPGKDGRPSSQHNDTCAQNVPGFSADGKCRCTYEIDGRDDNGCAKAFIYTCIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI69</accession>
    <name>A0A0N4UI69_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1704</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI69"/>
    <dbReference type="STRING" id="318479.A0A0N4UI69"/>
    <dbReference type="WBParaSite" id="DME_0000728601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000728601-mRNA-1"/>
        <property type="gene ID" value="DME_0000728601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000728601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8391" checksum="28496BDC12607955" modified="2015-12-09" version="1">MPEIDPNVDQLTQFREICHEKVQKFKERLDECNKRVTSRKKTSETCHEEMVEYMHHLDHCAMPQAFATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIN3</accession>
    <name>A0A0N4UIN3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">39S ribosomal protein L12, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1761</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIN3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIN3"/>
    <dbReference type="WBParaSite" id="DME_0000746801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000746801-mRNA-1"/>
        <property type="gene ID" value="DME_0000746801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000746801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21350" checksum="71427316F13306C9" modified="2015-12-09" version="1">MAVTLSCSFGKQISSLLIRSNLRRNLLMRMSSVEAKEIAIEPGPPSPVPTETRKVSERIEALVDQITNLSLLEVSDLNYALRKRLNIPETIAMPVGMVTNTPRIVPEEEENSSIQKEKPQKISFRVMLNSFDETKKVPLIKEIRNVIPGLNLVQAKKFVDSIPAVIKQDIGKGEADELKAMLEKVGGVCEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJL2</accession>
    <name>A0A0N4UJL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJL2"/>
    <dbReference type="WBParaSite" id="DME_0000785401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000785401-mRNA-1"/>
        <property type="gene ID" value="DME_0000785401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920525at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000785401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11710" checksum="04E3DE2EF67131F1" modified="2015-12-09" version="1">MTSNELIKRNILQFVASQYDPLGFLVSIIVRFKLILWKKTWDQVISYEYQQVWESLINDKTTNYGVRNSDILEKRNASGHNVSFKHKGMKSMKKWKKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJM7</accession>
    <name>A0A0N4UJM7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10220</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJM7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJM7"/>
    <dbReference type="WBParaSite" id="DME_0000787101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000787101-mRNA-1"/>
        <property type="gene ID" value="DME_0000787101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21525at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="8"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000787101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="708" mass="80650" checksum="4F72AA11F9EF5EFC" modified="2016-06-08" version="2">MNDSEGDSIKVVIRVRPLFSGETNEQIEWIAYDGRFMQRVNGNEIYEFDRVFDSLSNTKDIYREYVQSIIDSAINGYNGTILAYGQTASGKTHTIFGSCSEDGIIQMAIRSIFDAIASRSTSRYLLRISFIELYNEKVRDLLVDNSKDLSVKEIKEQTVIQGIKEEVITSDTSADYLIRMAYDRRVVGETTSNQRSSRSHVIIRLIIESHDALLGESSVSYISHLNIVDLAGSENSNCVSCQKERIVEGASINRSLLALLRVIQQLSDKCDHISFRDSKLTRLLKSSLGGNARTIIICSVSPLVNTETLQTLRFASRAKIIKNRPVQNKTSDDALLSRYLRMIEDLKAQLKENQRIEKNERDVANYKENLIKLKGCILYGSNFSGYQNRRKTWGGGRFICPSEFSLKENTLKEDANEASYNLSVYPSVDGGSMNSIEEFQKNCEENENASVLDYSIIGFSTCHQEIDDTLSEENRFHNRTSSTQTSTISITVSTEIEADLFSMVEKSCQCPEDNPDLPLYNDRQSFEERFKISESKNMELMNIIAAHEKKIENYLAILKVGKAKYGKIKVENYEKNALIRELEERIAILQKENDHILNYQRELLSSKVTLESIVDDGKKEIINLKTIIDKKNKDEISKNIEIEKYRIEKNEVEKKKLIFLIECNLGQRKTSLPTNPLSEIMPLDVFSPPGQSSPNLTPLSYFKKVKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJR9</accession>
    <name>A0A0N4UJR9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THOC2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2046</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000043">
        <property type="protein sequence ID" value="VDN52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJR9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJR9"/>
    <dbReference type="WBParaSite" id="DME_0000792101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000792101-mRNA-1"/>
        <property type="gene ID" value="DME_0000792101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000792101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38653" checksum="DA3F847ACEDB303A" modified="2015-12-09" version="1">MLDVLSALDAEIDYCVWNFKVVPEDVMKLELEPLGANETTTRSRIVKTKTRLFFKQVKFNLLREENEGYAKLITELYENHSRSASSTLTILYRLIGQFNLDPNRVLDIILESFEAFPQRRSFFISLLNEYKANSDVICSIIGFKFTFYQNSTGTPFSLFRLAAILCMERIIDVLSLCSYLTPKSETLMSDYKTRLERDLARSKKAEIISTAQIPAEIRPANSALIDDSFSNPVTGISFAAVAAVQETEDLKFLEGENSDEMNLNKNQKLGLTFALLEEGAWSLAKQLLDRFPEFFAVNASKNIALSISDLIERSIDDFYQELVFFLGSLRFKIFVIFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJV7</accession>
    <name>A0A0N4UJV7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2091</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJV7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJV7"/>
    <dbReference type="WBParaSite" id="DME_0000796601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000796601-mRNA-1"/>
        <property type="gene ID" value="DME_0000796601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790915at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000796601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35960" checksum="D929AC6A8AA9FF1C" modified="2015-12-09" version="1">MYVKYAIKNCNYKCEVTTDQKKYLSAGAVLFLLPNPKLMPIARHPNQLYVFLNGESPINSWKIPESMNEEFFNITMTFRLDSDIPCPYGGLRRINNSTASNKIWRWKQAKYNFKLKVVRMVKQKTKSVLQFVSNCNASSGRDLYTKELAQYISVSLYGSCGEKICFGHCEKLAVAKHRFYLAFENSICKDYVTEKAFYRLDQLLVPIVLKGSLYKNILPENSYIAADDFDSPKDLAKYFKWTKKYTKTSFIATPTSSIFISGFCKLCEILHRGVKKSTTVNIKSWWFEKGQCEKFYVQRLLNRKKRSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJY4</accession>
    <name>A0A0N4UJY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2123</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJY4"/>
    <dbReference type="WBParaSite" id="DME_0000799801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000799801-mRNA-1"/>
        <property type="gene ID" value="DME_0000799801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867992at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000799801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="7025" checksum="FC1E66672D5BE10D" modified="2015-12-09" version="1">MTISCKKWQEEERTGLAQNFFVLHDLEELLEQMIDTYVNSWYKSEISSDNTLVNEVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKJ4</accession>
    <name>A0A0N4UKJ4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">26S proteasome non-ATPase regulatory subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10325</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001211">
        <property type="protein sequence ID" value="VDN60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKJ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKJ4"/>
    <dbReference type="WBParaSite" id="DME_0000826401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000826401-mRNA-1"/>
        <property type="gene ID" value="DME_0000826401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000426">
        <property type="entry name" value="Proteasome 26S subunit, non-ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000826401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75180" checksum="F688A90F7CC25FC1" modified="2015-12-09" version="1">MLTVMNYCGFGYISMIINLSEVLMALYLLNRWKKRPGGPMNASAFLLALSSEYTPIREKEMIIRAFDDWDILTSTWFEVADYLDVIEKLYENEKFERRHIAALLASKVAYCLGDYSGALNLALAAEDEFKLTPRPMSPYVGYQDEQYVNKMIEQALDTYMTDRCAGNEVDPRLETLINRIFERNMKRKELRYVIGLALDTRRTDMILAAIKAAEDQAALLAETVSKVLESQMNRTFRNQVLDLLLNLFSELEEPDFVSVCQCLIKLEKPDDVAEILNRLVVNQGNGLLLAYQIAFDLYENASQQFINKIEKALIVEPTVFASSETMQTDDQQSVVTDLVEAVCGPEGSLSSKICLKDNTVRERLRSILCGEQTIKHHMQFLIKNNHTDMLILKQMKESVRTASAHNATVIANGLMHLGTTTDDFLRDNLDWISKATNWNKFNAVASLGLIHKGHEANAQKLLEPYLPKGEADQFGFKEGGSLYAYGLIHANHGNAEVIGYLRDQLQRATTSAVRHGACLGLGLAAMGTHDEDVYIQLRDCLYQDDAVTGEAAGLAMGLVMVGGLHGGAFQEMVQYICDTQHDKIQRGLRSGIALLMYGRQEEAEGFISQLMVEHKSNAMLRSTAMCCLALAYAGSGQANIVRRLLVSVANDPNQDVKRFAVIAIGFVLSKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL97</accession>
    <name>A0A0N4UL97_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10408</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL97"/>
    <dbReference type="STRING" id="318479.A0A0N4UL97"/>
    <dbReference type="WBParaSite" id="DME_0000856101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000856101-mRNA-1"/>
        <property type="gene ID" value="DME_0000856101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232837" evidence="2">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000856101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19302" checksum="9A5BC045F24FF439" modified="2015-12-09" version="1">MFGLLIVCYLLCVAESADLSVDIVECKNAGPVFKPEPPPSACKNKDEALCVAVFNPLGSDAANNANPAMTYKVNANCENATLKANALALCPSSCALCCMAPEFSCNNAVGANCAPFTVSPDLCTNSQTAAAALANCPKACGLCNRPGAGGRCPNAVTNCATLLPLLTCTNAYMQQNCMETCRITTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULY9</accession>
    <name>A0A0N4ULY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10492</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001220">
        <property type="protein sequence ID" value="VDN60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULY9"/>
    <dbReference type="STRING" id="318479.A0A0N4ULY9"/>
    <dbReference type="WBParaSite" id="DME_0000883601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000883601-mRNA-1"/>
        <property type="gene ID" value="DME_0000883601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000883601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16485" checksum="858ECB99DD9C51EE" modified="2015-12-09" version="1">MRYRAPAPRTKWDGILDVSCIFNASDANRLYGINIMSEDCLHLNVFSVKSCTMTSMCPVMVGILNVMPQSLNASNNNYYLIDQIEALKWVKREINRFGGDPKRITLVGIGAGAINVDQLALSPLTNGLFQQIALLGGSAAMIPYIDDCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM26</accession>
    <name>A0A0N4UM26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">JNK1/MAPK8-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2724</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM26"/>
    <dbReference type="STRING" id="318479.A0A0N4UM26"/>
    <dbReference type="WBParaSite" id="DME_0000887801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000887801-mRNA-1"/>
        <property type="gene ID" value="DME_0000887801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000887801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36380" checksum="70C712B9BD18372B" modified="2015-12-09" version="1">MVDDGARKLAATQICPGFCGRVTSQWSPGNISYSSCQACSWGYRSIDKFLCTACEEPLLLYDWLYLTFIAVIPLLMHNFFIYFYSKYSNRLYQVSQYLCCFAECFISAVVSVLIMPPQGSFKLYGCSKTHLREWYPIFYNPVINHSHALRCTNEIVFPLYSLPFIYFAMVLVSLLILRSCLYLTLLRGTRVSSRPYYAALYAIPLISLCHSLLAGILYFIFPYVALLFSLGLNALHMALELNKTIRRMCLEMITKPHNISILIVHMALFGFSLFSLLSSRPISTDMVSIAVTVIILVPLPSIFYIFTVGITFPVYVHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM49</accession>
    <name>A0A0N4UM49_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2749</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM49"/>
    <dbReference type="STRING" id="318479.A0A0N4UM49"/>
    <dbReference type="WBParaSite" id="DME_0000890301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000890301-mRNA-1"/>
        <property type="gene ID" value="DME_0000890301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000890301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="26153" checksum="1E12B84BF0859F4C" modified="2015-12-09" version="1">MTISYNLDVASASPLNFFRLIFRWKASIWKICLKELLVWTIAFLLITFVYRTPYFLNDYQKTVFEQLAVYFDSHLKYIPLTFMLGFFVQIIVKRWSILFQNMGYVESSALYIGGYVYGADDECRLLRRTMARYLCLTQLLVYRDISVRVRKRFPTYDSIIQAGFMLEHEKEKIESVKLNFNKYWVPVNWIYALIFRARADGKIISDSFTNKLCDVSFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM52</accession>
    <name>A0A0N4UM52_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SUMO-activating enzyme subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS2753</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM52"/>
    <dbReference type="STRING" id="318479.A0A0N4UM52"/>
    <dbReference type="WBParaSite" id="DME_0000890701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000890701-mRNA-1"/>
        <property type="gene ID" value="DME_0000890701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="16">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="17">
        <location>
            <begin position="458"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 15">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN52780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000890701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66123" checksum="91AC58EAB2F443E4" modified="2015-12-09" version="1">MVEDLQTDWYDSSFLSCLGCRVLVVGAGGIGCELLKNLVLTGFTNIDIIDLDTIDVSNLNRQFLFRREHVGKPKVEVAVDAVKAVAPEAKVLAHHDSVLSSKYDVDFFQQFTVVLSALDNREARIHVNRLCLAARVPLIESGSSGYLGQVNVIVRDQTECYECLPKSEQKSYPGCTIRNTPSEPIHCIVWAKHLFNQLFGQPDAEDEVSPDMNDEENKYHFAAEETVESGLENRNYQANGDHYFATDNSYALCTSESTRQWAENNNFDPVLLFTKFFHDDILYLLSMSNLWRERRKPTPLIWDSLPDQNPSASRSKSANDLWTVLDCRQQFEDALNILGKRVRDGSVLVWDKDDDAALRFVTACANIRAHAFHIPMKSLFDIKSMAGNIIPAIATTNAIVAGMIVIEALKVVFDRLPALRNIFITRLPNPRGKVLVDQVPNKPNPNCYVCSNRREIVLKTNVNLTTVNALEIKFLKTVLHMVAPDVIISGTGVLVISSEQGETNAVGELTLENVGIINGCVLECDDFLQKLELRIRIVESNQLKSDEFDIVNDSAQMDQESEEKAVKRASNLYAEDLLAKRVRNTIGDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMA3</accession>
    <name>A0A0N4UMA3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WPP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10518</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001222">
        <property type="protein sequence ID" value="VDN60545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMA3"/>
    <dbReference type="WBParaSite" id="DME_0000896701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000896701-mRNA-1"/>
        <property type="gene ID" value="DME_0000896701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000896701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10556" checksum="58F10A70FC0DAE6D" modified="2015-12-09" version="1">MWLEKKGEGGKGEEGRCVTSGTWGSEEITAVAECNGIRRIKGLQIEDNALGSDAREGAKTARSLAKKCFKRVAVSDSNGGRVLRSLEEVLRSVNVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMN8</accession>
    <name>A0A0N4UMN8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2860</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000085">
        <property type="protein sequence ID" value="VDN52887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMN8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMN8"/>
    <dbReference type="WBParaSite" id="DME_0000912301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000912301-mRNA-1"/>
        <property type="gene ID" value="DME_0000912301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="243"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000912301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33574" checksum="4B5E3DFB128BDFAC" modified="2015-12-09" version="1">GAKLLVRPDSSTVPDDTKISFFCRADGNPIPSVVWKKNGEIITDPRFISKTLANGLSTLRIEPVKMIDANSTITCSADNGVGNPVVADATLRVLSHNSLPLGFPIIETHPVLKSVEQGRTAHVSCRVKGDPRPKVLWLRDLMPIDIRSNNRYSVSTLGNPGALMIQQAREEDQGRYECVARNTLGVIHSKAAHLYVKGQIMNNFPHASYPISFDKFFLFFNIFYIFYYHFTIYVTLFIRRVPPYFSYKLERLYKVAPGGSINLTCVAVGYPMPRVFWKKSDETYLNDPQTAPIGFDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN13</accession>
    <name>A0A0N4UN13_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10632</name>
        <name evidence="2" type="ORF">DME_LOCUS10633</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001230">
        <property type="protein sequence ID" value="VDN60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UYYG01001230">
        <property type="protein sequence ID" value="VDN60660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN13"/>
    <dbReference type="WBParaSite" id="DME_0000927501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000927501-mRNA-1"/>
        <property type="gene ID" value="DME_0000927501"/>
    </dbReference>
    <dbReference type="WBParaSite" id="DME_0000927601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000927601-mRNA-1"/>
        <property type="gene ID" value="DME_0000927601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000927501-mRNA-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000927601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9762" checksum="2B86AA8940BC02F2" modified="2015-12-09" version="1">MVIIGVDRNERVGHGAATIKSASDMEIQCANGERLLLFAEEQEEQLFVTNAYFRRRKRHLITYSSPYNQHFNQIDYVLSATGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN44</accession>
    <name>A0A0N4UN44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3031</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000098">
        <property type="protein sequence ID" value="VDN53058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN44"/>
    <dbReference type="STRING" id="318479.A0A0N4UN44"/>
    <dbReference type="WBParaSite" id="DME_0000930901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000930901-mRNA-1"/>
        <property type="gene ID" value="DME_0000930901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF66">
        <property type="entry name" value="BAND 7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000930901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31781" checksum="DB8F1EEA44DBEAC9" modified="2015-12-09" version="1">MRARSQSWLIRTRHMLDDDTPRTPVISGIMYALSILLLIITFPFCLPFCLKIAKEYERAVVMRLGRLIDGGTKGPGLFFVIPCIDTFRIVDLRVLSFDVPPQEILSRDSVTVTVEAVIYFRVSNPVISVTNVNDPQFSTKLLAQTTLRNVLGTRTLSEMLSERDSIANVIEKVLEEGTDPWGVQVQRVEIKDIRLPHTLMRSMAAEAEAARDARALIIHAHGEQKASWSLAEAASIIGGSKVSLQLRYLQTLSNISSEHNNTVVIPYPMEIARHFAQKWAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP84</accession>
    <name>A0A0N4UP84_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3370</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP84"/>
    <dbReference type="STRING" id="318479.A0A0N4UP84"/>
    <dbReference type="WBParaSite" id="DME_0000975401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000975401-mRNA-1"/>
        <property type="gene ID" value="DME_0000975401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000975401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35834" checksum="7D31A8001F4C87DC" modified="2015-12-09" version="1">FCERKRIKINTSFLTDPSKFIQYRSAHATNTIINFVPQQEAWVVERMGRFHKILEPGFNILIPLLDRIKYVQSLKEIAIEIPHQSAITIDNVQLQLDGVLYLRVVDPYKASYGVDDPEFAITQLAQTTMRSEVGKINLDTIFKEREQLNICIVDAINKAAEPWGLQCMRYEIRDMTMPAKIQEAMQMQVEAERRKRAAILESEGKREASINVAEGEKRARILASEAAKQQQINEAIGEAEAILARAKARAEGIKKVSDALKDQQGNDAAALNVAEQYVKAFSNLAKEGNSIIVPSNISDASSMVAQALTIYKQLIEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPE6</accession>
    <name>A0A0N4UPE6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10759</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001244">
        <property type="protein sequence ID" value="VDN60786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPE6"/>
    <dbReference type="STRING" id="318479.A0A0N4UPE6"/>
    <dbReference type="WBParaSite" id="DME_0000982901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000982901-mRNA-1"/>
        <property type="gene ID" value="DME_0000982901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="206"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="524"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="633"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000982901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="707" mass="80636" checksum="29C35B6ACBDAE734" modified="2015-12-09" version="1">KPQPTIEWIDNRGQPIGHDSKRFKVISKDNQTSLTILGAQIEDEGNFTLRITNKFGFDTCEIPIQVIDYPDRPGRPIVCEQSLCLVRLMWATSGQESTSPIIYVIEQRREDEDVWQKVDAVKQSSTTICNLQVNHIYKFRVRAENNFGQSDPSEESESIFVPDPKYRKENDHVLADNCSKFITDIKPSEYRTIDVTRLPNDFEAKYILCEELGHGSYATIYRTIEKSTGKNWVAKIVKVRPGIKKDSVLHEINIMNQLHHEKLLNLHEAFDLGSEMYLVEELVSGDELLDKIFKDGGSINENDIRNYVRQILQGIQHMHSKGIAHLDLKPETIVLQSENSNQIKIIDFGLARKIDPTKNCKLLFGTAEYCAPEIINSEPLSLSVDMWAVGVITYVMLSGISPFASANDAETLANVAAGDWNFDDASWNNVSDMAKDFISRLMLKDKRKRLTVTESLNHPWIMELGQDIQNITLRQIKNFLPTIKYSGDDLLPLGRLVHRGSLFRQISMDGVFERNVTFDEEYPPKVLKPLENMTANIGISVIQLICSIDGSPSPKLQWFKDSHELIQPSKKYNMSFINGTAELSIKDIEEVDAGLYSVTATNELGSIQCEAKLIVQHQQTTKRFENELEITLPNFHRKLTNAVVKIGEPVLLCASSNCEPQLDVKWYRNNEPIDINSARYVTRSNKGHKNENENFFDRFCSRSHYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPI0</accession>
    <name>A0A0N4UPI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3448</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000134">
        <property type="protein sequence ID" value="VDN53475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPI0"/>
    <dbReference type="STRING" id="318479.A0A0N4UPI0"/>
    <dbReference type="WBParaSite" id="DME_0000986701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000986701-mRNA-1"/>
        <property type="gene ID" value="DME_0000986701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847125at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="145"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000986701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37438" checksum="38C114FD5496D0E8" modified="2015-12-09" version="1">MQLSDFPQNVRVLLCFEEVSEHASKSLLKGMNLNSTVTDEISPPITQMRKNFMRQSEFDELYDFCPPPKIDKKVKNYAKRILYPFFGKRQFLTFLVSLVPCIKWLSNYKWKSYIIGDFVAGITIGVMHLSAIKNYKKNLKCNSCLGIAYAILSGVDPVYGLYSSFFPVLFYMILGTSKHASIGKFIFFTRSFAIVNLMTGTSQSRILTKINQNHLENEVSYIGNAVKMGASTAVLQNLTANIPLGLKDVTSIQIVSSLTFCVGIVHILMAVFRIEFLASYLSDQLISGFSTGASIHVIIVQLDKIFQINVARKNDRVSINLVVKTMSMAFFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPJ3</accession>
    <name>A0A0N4UPJ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10787</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001248">
        <property type="protein sequence ID" value="VDN60814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPJ3"/>
    <dbReference type="WBParaSite" id="DME_0000988401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000988401-mRNA-1"/>
        <property type="gene ID" value="DME_0000988401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="329"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000988401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48417" checksum="A3BAD2FA315B7A82" modified="2015-12-09" version="1">MIFVPYLFDTTKNSSSYWNCIQRCSCTTDSYEEIDGQCIEQKNDATAKNITSSTYDCSLEGLPCGTNMIFNPVHEINFQNTSQCITQCVCDINYYEENDQCIKKNDILSAYMDNPCNLEPCKVDEIIHDAGCRLTGHKCGINMIFKLISQGITYPSISRYCTQRCVCESEEFVAKTFHCEKTKIHLNDSIESSEFLQYCPRLRYNMDEEITDLGCRLTGFKCGKNMVFVPVEEFFWYCDGGYCSLGKQVFDYGCMLTGLPCGTNMIFDTMNNNSTEFCIQVCKCAANDYTEINGRCHKEDNTTSKYFVEVRKSFIVGQIFDDFGCFSTGITCGKNMVFRPIFQFHNISGLIWYKKCLQRCSCKNDKYIERNKNCIKRMVEIENPPEKNTTMIDRPCFINRSCQLGDTIIDKGCQLSGLKCGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPP3</accession>
    <name>A0A0N4UPP3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3491</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000140">
        <property type="protein sequence ID" value="VDN53518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPP3"/>
    <dbReference type="STRING" id="318479.A0A0N4UPP3"/>
    <dbReference type="WBParaSite" id="DME_0000994001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000994001-mRNA-1"/>
        <property type="gene ID" value="DME_0000994001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001145">
        <property type="entry name" value="Jitterbug, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF16">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="307"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="400"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="478"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="585"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="667"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="776"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="940"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1272"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1486"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1582"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1471"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000994001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1861" mass="205152" checksum="4A0A7325B62053F2" modified="2016-06-08" version="2">MADGQREENLFEKDEELMHSKPTSTSTTPKSTPKTTPKLNLKFAKQAQEGKVFDFGKSKFTSKHEVVRKGKDVDVKLESLKLAKEDQLRFVILPPNKANLEQLEIEPKIKKSRHNYEISFRPTEVGTHKVMVYVNDVLHPQCPFPIRVYDASEIIVGEIAPQSTINDTVEFTVDAGRAGFGNLEMAIKDSDGVIIPSHVAQLESGTAKFLVTFNPTSVGMHTVNITFNKEVLKNSPFEVNIVEAKPIVTDSGIIDDKKKEKKQKEERKREEKEKQKKEREEKQLAETLKKNREKELKKKKHILDRKPSLSKIPSLSRVNKSAQIVVSVYDDSPLEVSVKDPSKNLIDYSISDHESGGKKVEFIPVKVDIKGDHEVDIKCGGIDVQGSPFTCRAYDPAKIGVGNIPNGIVEQAVHFIVDASEAGVGNLEVAVNEGRVPSMAQSLGQHRYDISFIPREKVDHTISVRFNNEPVPGSPFICHLVSTHSISASGPGLERVPVGQTSEFFVLIEGDQSDIPSVRITDSQGNNIPVRVDKDNAADSRFIINYTPQIVGNHQIEIEHAGKPVHGSPFTSKAFDAKCARLSRVDAAYVGRPCTFTIDAARAGAGNMEIIVSVDNRNVPNFVQAEGQAKFKVSFTPQEAKDHVISVRFNGEPIPGSPMVCPVSEVSQSVAAVVPLSSGPDIAQQARLVGDISSAQVGNVKGFTVDTGGRDADCNVIVIDPIGNEVCVQMERVSTGYLAQENKNDEIYSGTYGVRIEIDGKEMNSSPFVIEVTGQPKISRIPSVVFIGKEMAFNAETDLANRRNINIEIRGEDGRTIPVRTSVDNTGIKASCKFRNVGRYSVNITLNGKLIESKTIEVVEPGVGVSLVNDIDQGFVGQAYKVLLRIDNNSLKKLVAVAVTGNWETRIAINRPITDFKWLIFNWNYWSSMNLNTSVNVLFFTDQERNPVSVSLKKISDDIFEAEFTPLFEGTHKIAVTIDERHIRGSPFTVTILDLSAVRIIGLKNDAVGVEQRFNVDWSNSGGSEASVRVTKDNSEVPCTVKKIKQGLHVCSFTPNQVGLYLIDVYVDGTLLPECPYECIVNDMGAVRARGDALTRAQRGKIARFEVSVGNNTRRELDVLVRDSHGSPLPVRCYKQHDDSYWVEFTPENIGSHKIEVTFGDVPIAGSPFHCEVVDPRKVFIRGNTEPLILRQQAVLTVERENAGNGELKVEIVDPTGQPLKIEKTKSPNGEERIIFLPTRLGQHKLTAKLSGFVVNGSPQMLVVEEQGEPSLYGDALNRPAEVEQPVILIFDSKKQKGALKVDIRGPDRSKARFATNKRSDGNVEIIFNPSEVGQYMVNAEMNNKPIAGSPFDVSVVDARKVLINDELADDKGTFHFPIQQNNIIDVDATAAGPGKLRAEVRDGSGKVMDAAEVESLGYGKYRIIFNPQIAGKFNIYLYWADIAVESAFPIHIIAETEQPSTSRVMPLSDEIDHRSRSRSSERYEDGQDDHQRIIARGDGLTKAIVKEQSEFIIDGSDSNQDGHISCSLIGQKADVPVRLIHLGNNVYKASYTPLISGKYELQIMWNGRQIRGSPFKVNVDSHTSAAELINVDTSTLKFGVINEDIKTVINTRKAPPGQLSAQCMGPSKLAYCELYDHRDGTYTLSVKPSEIGKHTLVIKYSDEHVPGSPFIVNVSHAPDASKVRVYGPGIEHGILSTFKSNFVVETKGAGAGQLTVRVRGPKGAFNVEMQREKKQERTIHCKYEPKEPGDYQVEVKWHGEHVPGSPFLVMIVDTEQELQRFLRGDAPSPQPATPFIPPGWVGTPPPPPPLFLSGAGIRPPFPHHPSFSPPHPHHGPILPYAPLPPPPMRAGVRPKYASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPR8</accession>
    <name>A0A0N4UPR8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10818</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001251">
        <property type="protein sequence ID" value="VDN60845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPR8"/>
    <dbReference type="WBParaSite" id="DME_0000996801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000996801-mRNA-1"/>
        <property type="gene ID" value="DME_0000996801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000996801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27595" checksum="8BD0E0EA520519ED" modified="2015-12-09" version="1">MIKRERRKSAAHIGECNEIILLQCLHYEYAVLLGSGGLLGQLSVEKSLLLAKHRKIKQNYSLNNELMILDSANAMTEVIRECHNGGSTMDQVPPGQIPRRPVPSATACRDSDQNLCNALFPLNNDHANNADPKKPYKAHQDCYKATHSSIATRFCASTCALCCKTLQFSSCPDTASNCTLFAENPALCSSPQLSAFALERCAKTCGTTTVASSNCRDERVDCARHQQFCHVHPFSSYYNIYCRKTCNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQI0</accession>
    <name>A0A0N4UQI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3768</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000183">
        <property type="protein sequence ID" value="VDN53795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQI0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQI0"/>
    <dbReference type="WBParaSite" id="DME_0001026701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001026701-mRNA-1"/>
        <property type="gene ID" value="DME_0001026701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803975at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001026701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16466" checksum="E9EAAB6D9B8AD18B" modified="2015-12-09" version="1">MIQLLSFHKKCLQKLIKKLLSILFFIGEKMFITALNHQQAPIPCVLDELGTHEHGQTFTKGNFHYKCNNGTSEVIACVSDDKSVIHVGRTFLHEGIKHKCSVNGDIVTYEKESTCFENGIHYSIGESFRNGSFKMVCEENGISIAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQP7</accession>
    <name>A0A0N4UQP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10876</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001264">
        <property type="protein sequence ID" value="VDN60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQP7"/>
    <dbReference type="STRING" id="318479.A0A0N4UQP7"/>
    <dbReference type="WBParaSite" id="DME_0001034601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001034601-mRNA-1"/>
        <property type="gene ID" value="DME_0001034601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001034601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24212" checksum="50F85EB654220BE0" modified="2015-12-09" version="1">MGVTKDYLRYNLSGTCNIIASTNGVLVAITDSICAVAACENVYFYNLRTCEKISEISGSGKNVTTLIFSSNKGFLAVGYADGIIRLYSKLNKDKCEFITFSGHKTGVNCLAFSPDELVLASGGKDSRIVLWDIVNECGLCRLNGHKGCITNLQFTQNGHFLISSSKDTFIKFWNLHTENCFYTLTDSRSEVGRLWLELFGIELSFSRIFSVKYFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQR1</accession>
    <name>A0A0N4UQR1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone chaperone ASF1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3834</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000197">
        <property type="protein sequence ID" value="VDN53861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQR1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQR1"/>
    <dbReference type="WBParaSite" id="DME_0001036401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001036401-mRNA-1"/>
        <property type="gene ID" value="DME_0001036401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001036401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15230" checksum="A320D152B4C9AD4A" modified="2015-12-09" version="1">MSSAVNVVSVVFHDNPAAFCDGFKLEVTFESEALQEDLEWELVYVGSAESTKYDQVLDSIVVGPVVEGRHKFMLETNGPDPSKIPMSDIVGATALLLKGSYRETEFINIGWFVACEYIDPELKEEPPATPIVEKVCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR38</accession>
    <name>A0A0N4UR38_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3952</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000229">
        <property type="protein sequence ID" value="VDN53979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR38"/>
    <dbReference type="STRING" id="318479.A0A0N4UR38"/>
    <dbReference type="WBParaSite" id="DME_0001050801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001050801-mRNA-1"/>
        <property type="gene ID" value="DME_0001050801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40953at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001050801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24040" checksum="C13CD3C75A5DFBCF" modified="2015-12-09" version="1">MFSCLFPPLRICLECVQGPSFTATQSYAQFQNETRSVRLDTSHMGKFFIFLIFNKLILTFLGDEVVLLKNGQRICGVGGALATAPILQNKAYFQVSIQQSGIFGVGVANPSVNLNSVPLSKNSWFLKEDGQLMGNSEVVGHLTEPLEEGDCIGVAFDHVDLQFYRNGLRLPLSISNIKGQIFPMVYVDNGAILDVSFSSFGYNPPPGYEEIMLEQTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URV1</accession>
    <name>A0A0N4URV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4184</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000372">
        <property type="protein sequence ID" value="VDN54211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URV1"/>
    <dbReference type="STRING" id="318479.A0A0N4URV1"/>
    <dbReference type="WBParaSite" id="DME_0001078301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001078301-mRNA-1"/>
        <property type="gene ID" value="DME_0001078301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920068at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF14">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ACL-12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001078301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46777" checksum="651F77A5A2E59175" modified="2015-12-09" version="1">MLTPGAEQISGIDGSTMNVEDSFITKIVANSMDLRKIIAVIGSFYWIIMTIFIVPCAVVATFLTILLPIILINVRIYNWIDHKLCRMVNDHWVSALLNVGLNIVEFGDDISEVANKRVLFLSNHLGLADHFIIMTALHNKGTVVEKYLWVIFNIWKLTPLGAMWLIHGNFFINGGSSKREKQLNDFKEHLRKYYWKHDYGWLIMYPEGSRLFLIKENNKRFAEKIGHKVYKHCALPRVGAAHAALGISLFSLGTSDVAYSGLGKPIEYIVDCTIAYYKGDVANLGQYLMGEFPHGVSTVGIHYKESFPFLILKMVIPVKAEWIDESILKKWLYSLYEKKDELLDYYYKKNSFPDHGKTRPRPVFFPFSRFIIVEFFWIILFYFHYISWIKPLFSSLRSAIFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URV6</accession>
    <name>A0A0N4URV6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4189</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000380">
        <property type="protein sequence ID" value="VDN54216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URV6"/>
    <dbReference type="STRING" id="318479.A0A0N4URV6"/>
    <dbReference type="WBParaSite" id="DME_0001078801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001078801-mRNA-1"/>
        <property type="gene ID" value="DME_0001078801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852176at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001078801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10239" checksum="758D2EECB4D6F9E3" modified="2015-12-09" version="1">MADINDVNPPRGAIKKAYTAKPYGEFCPECQCKVRTRQKFITGRLTWILAIIGCLFFIPLAVVPFVVHPSKDVLHYCPNCNTLLSIRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USA9</accession>
    <name>A0A0N4USA9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4331</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000807">
        <property type="protein sequence ID" value="VDN54358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USA9"/>
    <dbReference type="WBParaSite" id="DME_0001094101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001094101-mRNA-1"/>
        <property type="gene ID" value="DME_0001094101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001094101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3859" checksum="296E9C246E3190CA" modified="2015-12-09" version="1">MDGSGGNPSSYQHLFWVMPVFGIASQRRLYLTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2I6</accession>
    <name>A0A158Q2I6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2I6"/>
    <dbReference type="STRING" id="318479.A0A158Q2I6"/>
    <dbReference type="WBParaSite" id="DME_0000017501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000017501-mRNA-1"/>
        <property type="gene ID" value="DME_0000017501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843400at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000017501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58948" checksum="7352CFA6AE3445E8" modified="2016-06-08" version="1">MEVEALLNNTSALFSSTFAILSNDDGLSATQWDYRMANVSGLNTHVDINYVNNSSDQFQHFYGQQREIYAHGRCDDVYPNGVILSNSDSLVPENTSQQRPFVMDEQYPSTSNNTDSASIISCSAPQRFNGDTNHKQFAKAKGSNLLPGSYSSSSTGESMNPVCPRCEKYISNYKGNMQRHMKTCGRSNRPKKYMVKSAKKKDLSATSFQSSLDYVNNAQYVTSGNNSDALCDSYQPNVALSGFSSHTLEEKSWLNNSERSCTSTPSLEPLIKKPDPYICSLCRFATIYKGNMKRHLITCHDLKENDMKDGNIDSLRASRCGALPGSPASRHTDTPHSTDEKRPCSEPPNVDSSVVASHNTAGSCSSFVTNDSFDSQTQSTVTVTQDDDAFELFNTCRERTVVKTECNASNMNIESADCDQKLSSIDETINAVASNYSLNMVGRKKSLQEKNRGSARGSKRMVRNMEELRGYWESERLNAGDRWELERPRSLGRGKGMHCGSEQNERLIIDSVMPPSTKSFTTPRFFAKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2X9</accession>
    <name>A0A158Q2X9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5455</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47780"/>
            <dbReference type="Rhea" id="RHEA-COMP:11911"/>
            <dbReference type="Rhea" id="RHEA-COMP:11912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2X9"/>
    <dbReference type="STRING" id="318479.A0A158Q2X9"/>
    <dbReference type="WBParaSite" id="DME_0000109501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000109501-mRNA-1"/>
        <property type="gene ID" value="DME_0000109501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000164">
        <property type="entry name" value="Methyltransferase NSUN5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="8">
        <location>
            <begin position="417"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000109501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="727" mass="84576" checksum="898A4A1CA043C14B" modified="2016-06-08" version="1">MEEKREKKFGSRYLIDDSMVFEYNAWDNFVWNRNDEEEAIREILRQNQSKICENDANKLIKNASKMWNKFYLKHKNKFFMDRNWLLNEFNELNLENLDHETPLRLLEVGCGVGNSIFPILNANQGRRIFIYACDFSSIAVDVVRNNIRYDENLCRAFVWDVCGEITSEVSCGSLDIVLCIYVLSAIPPEMQQTAVKNLVRLLKPGGVLLFKDYGLYDLTQLRFKNNRLIKENFYCRGDGTLVYFFTQEELDALFTNAGLRKEINIVDRRLIVNRAKLVKMRRVWLQFCAQSFKMDKIYYAAAEILEEIFNKKKNVRNAIYGSKCKRKKILLRLCSETIRYKKFLDGILECKEIRNLQKNWKNGSLFLLYALLYDFIFGNGSKKQNSRLMNVLNKFGDRINRKIDSLTALGRGPNICEVNKSDLMIPRYARINTLKWALKDALIALEKENWVIRKIEIDKGVKFFELVNSMKAEEVLLDCHIENLLVFHPRTDLHAYWMVFDGYLVLQDKASCLSALLLKPKPSYHCFDACAAPGMKTSHLSALLSNEGIVWAMDKDPTRIKVMRKMLKKLGCSNINVECGDFLRVDVNDEKYSRVRYVLVDPPCSGSGIVKRLDKFLDENSATDPKRLRSLSNLQAMMLKHAMKFPNLRRLVYSTCSVNEEENEQVVAEVINDEEIRSKFELSYALPSWPNRGLNSYDFGEKCLRTSSDYDLTNGFFIAVFKKVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q322</accession>
    <name>A0A158Q322_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS5837</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q322"/>
    <dbReference type="STRING" id="318479.A0A158Q322"/>
    <dbReference type="WBParaSite" id="DME_0000147701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000147701-mRNA-1"/>
        <property type="gene ID" value="DME_0000147701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000002">
        <property type="entry name" value="Alkyl hydroperoxide reductase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="12">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN55864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000147701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24590" checksum="F9979C08A38E634F" modified="2016-06-08" version="1">MFRFFMGTAVVDGDFKTIKVDDYKGKWLIVFFYPLDLISLTCNAAAQWRCFLLWQNDPWFDDSTFVCPTEIIAFSDRSPEFRKLNAEIIACSCDSHFSHLAWTHTPRKDGGLGKMEIPLLADFNKQIADSFGVLDHQLGVSYRGLFLIDPNGEIRHSLVNDLPVGRSVDEALRILKAFQFVEKHGEVCPADWEENEPTIKPDVSSSKEYFNKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3P2</accession>
    <name>A0A158Q3P2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS43</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3P2"/>
    <dbReference type="STRING" id="318479.A0A158Q3P2"/>
    <dbReference type="WBParaSite" id="DME_0000281401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000281401-mRNA-1"/>
        <property type="gene ID" value="DME_0000281401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15909">
        <property type="entry name" value="7tmF_FZD4_9_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07454">
        <property type="entry name" value="CRD_LIN_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041774">
        <property type="entry name" value="LIN-17_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044453" evidence="11">
        <location>
            <begin position="22"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="392"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="433"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="12">
        <location>
            <begin position="27"/>
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        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="199"/>
            <end position="496"/>
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            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
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            <begin position="40"/>
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    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="77"/>
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    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="108"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008077"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50038"/>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50070.1"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000281401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64936" checksum="15F314E171B6848B" modified="2016-06-08" version="1">MSKFYSSLTVLLLFLKNSSNASIFQQASRSRCEPIEIPLCKDIPYKYTFFPNSLLQPDQQSLQTQTEHFKPLIKTKCNPHIKFFVCSVFAPMCPEHMPQAVTSCRSVCEEVKRDCVSILEEFGIEWPELLNCSRFPEAPHLCMKPTNDHNNYLGSRIYLKAVPTCPSDMINLDPTDRSAHCAFQCNRDGMFERNRREFTKFWMLLWASVNLGVTAFTVLTFLIDRQRFRFPERSIFYLSACYMLYSLPTLSRGFFTYERIACDRIPTGQLFLIVGTLDNTRCVISSILTYYFSMACSLWWLMLTFTWYLSAARKWVPEGIEAWSSYLHLVAWALPALLTIAVLTAHKVDASELTGICSVGNADPWALLGFVIVPKFIFVVVGSCLIIAGFSSMCRERDSFRRRGTDTSKLEKLMVKMGIFSALYIIPAITMIICDSYHMFVLLKWHPNTIACKQFGGFCNRPEPPQIELYIINIFMSLAVGIATGMWIISPKTFYTWQRVLCCGLCSTAPAKQSAVGCESVAGSSGPFSLNRPLIPSANPPPPPHQYMPMTISTARSNHVASSQLAWKQSKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3T8</accession>
    <name>A0A158Q3T8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DME_LOCUS7304</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25 27" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3T8"/>
    <dbReference type="STRING" id="318479.A0A158Q3T8"/>
    <dbReference type="WBParaSite" id="DME_0000314501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000314501-mRNA-1"/>
        <property type="gene ID" value="DME_0000314501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
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    </dbReference>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF1">
        <property type="entry name" value="SODIUM LEAK CHANNEL NALCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="353"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="383"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="473"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="821"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="901"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="965"/>
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        </location>
    </feature>
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            <begin position="1079"/>
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    </feature>
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            <begin position="1160"/>
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            <begin position="1159"/>
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    </feature>
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            <begin position="741"/>
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    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00036239"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00061650"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="VDN57331.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="DME_0000314501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1635" mass="190319" checksum="2255164EC10C7383" modified="2016-06-08" version="1">MNYGIFDHILRFCCLISLISVCLNTPQTISYFPSLFYIICFTDGIITILFLLEAVIKIATTGLFATENSYLRERWCQFDCFLLFLHIVSVGLTAFELFTIWFPQFGLVYKQWYGVIRSPRPFIMVRFIRSIIRFKLPKNRIQQIIKRSSQQIQNVTIFFMFFMAFYAIMGVQLFGRMDYHCVLPGTNISNVTIADLAIPDTMCSQKGAGGYECPSNMECVKLHMSAHAEGFYGMFNDFGSSLFTVYMAASQEGWVYVLYDCLDTFPSYIAFFYFVTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMWQTREITSEDNFTQRLELTEEGWKLVAIDKAITHDLQLVKSTPFQFAMMVLLILNAIINASFVYKHDETDEERKLIYYYIEVIFTLIFNIECALKIMGIGWKGYVRRSLYKFEFILCIGSSLNIIRPLYSTNIFTYFQVFRIARLIKASPMLEDFVYKIFGPGKKLGGLVIFTMVLLIITSAISLQLFCYVPKLDKFRTFPQAFMSMFQIITQEGWTDVVVEILRTTNESMVPFVAIYFVGYHLFVTLIVLSLFVAVILDNLEMDEELKKIKQLKAREEITCMRTTLPWRLRIFEKFPTRPQMVELRKASSEFPLPKVRQSFTRQFTENDGIMMNVFVVNGNGSLILLVRQIGQLSSKWAVRTLIEESNNNRALLSDSNQYIPQLGRIGTRHWRDSSRMRNRCTDPSTKLKAMYEHFKENGDVRPVDSAPKDDLKQGEIDIKALQQKRQHAELTRNRIEEEIRENHPFFDRPLFAVGRDSRLRRICQEIVYAKYLPEKIDNVTGKQIQRRYKQLHALVGLLTYLDWTMVLITALSCGSMLCESPWPTTGENMIFNNPYLQICEYLFVVSMTFELAVKILANGFIFTPNAVVRDVGGVMTLFIYITSFIYLIWMPNHVEINSLAQLMMIFRAMRPLRIYTLVPHIRRVVVELCKGFKEILLVTILLVVLMFVFASFGVQIVGGKLAACNDPTITTRERCTGIFEQKIFVTRMEVYGKNDDNLHPKIWVPRVWTNPRNFNFDHIGNAMLALFETLSYKGWNVIRDILWVRQGPWAVLFIHIYVFIGCMIGLTLFVGVVVANYTENRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPAESAKLRTRLYEITLSKWFKQAFAILVVINSMTLFIPWNVEEEENSYNSVLFMTGLSAVANILFTVEIFLKMIAFTVRGFWQSRRNRIDLLITALGLFWIVTHFVMALPASAVGGRSQLKKFTYTFGYIVVILRFFTIAGRKTTLKMLMLTVVMSMVRSLFIITAMFLLVLFYAYAGVVLFGMVKYGQAVSKHVNFRSPKEALVVLFRSVTGEDWNDIMHDCMKSPPLCYWKEGVNYWQTDCGNYFGAIFYFCSFYLIITYIVLNLLVAVIIENFSLFYSSEEDALLSYADIRNFQQVWNMVDIEQKRTIPVWRVKFLLRLLKGRLEVDPTKDRLLFKHMCYEMFRIHNGDDISFHDVLNMLSYRSVDIRKSLQLEELLQREELEYIIEEEVAKQTIRSWLERCLRRIKAQQNKDIPLIAQLRPIINEQQFVLVQNQITNQMNAPDQPEQNMETSENDENELLRRKIARKSRRSSIPEIVGVCLKYFGVTCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q460</accession>
    <name>A0A158Q460_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deltameth_res domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS456</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q460"/>
    <dbReference type="WBParaSite" id="DME_0000409201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000409201-mRNA-1"/>
        <property type="gene ID" value="DME_0000409201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809766at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031973">
        <property type="entry name" value="Deltameth_res_prag01"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16020">
        <property type="entry name" value="Deltameth_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Deltamethrin resistance protein prag01" evidence="2">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000409201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8862" checksum="42A2C702EC6EBF4C" modified="2016-06-08" version="1">MMGTGYPGPPVTMDSIPVPFMPYKTVHRELQAKFNKCLIFGIVFYTLSLSLAFYDGVFMVESLRTPLSYRYRNKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4A9</accession>
    <name>A0A158Q4A9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8331</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4A9"/>
    <dbReference type="STRING" id="318479.A0A158Q4A9"/>
    <dbReference type="WBParaSite" id="DME_0000444801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000444801-mRNA-1"/>
        <property type="gene ID" value="DME_0000444801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="3">
        <location>
            <begin position="431"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000444801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55317" checksum="85FEDDFB04C013EE" modified="2016-06-08" version="1">MGDERYMNAPLGVLFVTMGANHEQISFSYPFSSNYIMTFDKECSPEQFVATTAVPVQILAYLLSAKGTCEKFFELKIDNIRFAGFPKIVSKPTGRSPQAFNIVFVLIANASVYLVQSFQLLSKKLAIALDEEQSRCGYLAEQMTSMLNDCDKTDSSIEGESLPYADILTRSQLAQDLKDLFTDISEFGIGHIFINDCVEVGFCIETRALIQAGLTPKSRMEIEKIVKRIRPYHGIILLGNTIPSPDANPSVRLFLKHCDPDRSIVGISDASGLPLVQVLLIVRHLLLWARAIIIYPLCSSNVYSSAAYHKPIVRLSEQFSELFENAQLPVILAQFSPPCTLAEFVNASFHSSEEQQIRVNMVIRLLRDSLIMQLHTFIYLLPSFSSSSVDELEIEALREENIRDLIISSKFSMDIKATLARLCLSLLRNSSSEQVANMLSLFIRLSPYLNGNHHVEDIMYRMNLDRSTVVRILDTFSCVLICYSRPEFPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5E4</accession>
    <name>A0A158Q5E4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9877</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A158Q5E4"/>
    <dbReference type="WBParaSite" id="DME_0000714701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000714701-mRNA-1"/>
        <property type="gene ID" value="DME_0000714701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250192at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="3389"/>
            <end position="3461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3537"/>
            <end position="3616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1206"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1292"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2445"/>
            <end position="2475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="3086"/>
            <end position="3113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3541"/>
            <end position="3555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3563"/>
            <end position="3572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3577"/>
            <end position="3592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000714701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3616" mass="416035" checksum="5E9387306B62A14F" modified="2016-06-08" version="1">MSGILETLNEITSAVSQRFCFVTSTEDATLAYDRMQEVRMQLVSWSTKIRESIDEVERLCIDGADLLTPQQFHTLKEQRNRLENVYNQLLRHTDKIIECLNELAKFLLEFTNESSIMHSLINEKTREIAIIKAESGDLNCYEMSRAKAKASLEEVISSEYRIKAISSLSSRIQEKLDAYLVEMRIQYPETQFTSVDIHDLLDTLTRLQKDYEILLRSCHELNAFLNKLKICNATYSDNITKAEKLIVDIEHSISSIEEIARNNSVDVDNACILNELESLQQATVDQIALNENVSRSAFELDNALVGTDAHDRIVLENQQRIDDLERRQKRVRQRIEEDIDSWRSKIAKSEGLREGLAGILNWLDDKEEQLSNAPLLPLSIDKLGEMYRDDELAQRELTSHENVLKDLSEEIAKLVSSNPNSANRSLADQVALAKKKFSSLSAISKAQGDNLYDLLIALKNIDKNSKLLDERIEIVNDKFSRVSLADTDSIVNIRAELDDIISDWKEIQQQNNWIHAVPNIIEGSSLEQKMTKIENAVDKVILRANDLTEQQKCLLDQRKTFENLKNEFVCWLKTEENEIKALGRISCNPVELDAQRNACDKLKTDHQCHRFDLEKLDELGSKLVEIDIETFAKTKSKSTSGRVTDAQATTVFRDLSCLRQQYDGIGQMIKARFEKINSTNEKFCEWDLARDDLSRWARNECRLLDTECPVALSMDDASKNILKLERLEKICSKEKQPLIENIRSKAALLMNDSELCDTHLIEISQAEFETHWSALEDQMTIIKNRTNACKQLIQDYDNLDKWLKQKERMVSVIGAVSVDPKVIDSQVLQIEILQGEIDDQNMQRNKINEIAHELVTSNDANSLQIVNRMDALNLRWISLEENVKTMKEALQKIKNISLQFAGLHRKIKLDLLEIHENIEKTGRSALTDQDNYNEHVEKFDFLTSQIGEVEKSLESLKTAVLNSKAEEGATMKEIEARLKWIRENRNRLAELGPISTDPRTLPEQCNQIEQIYQEVLDKEGEITLLRAKLGDQIKKASNSALKSIVESIVSEWNPLLIDVKSKKANVERTTDLVKQITSSFELFNAKQMQCKASMEQLSLSKLSQRYQKMNGVRRTFMRNLKNSIGAMSLNTDDNSNEIFELEQQIERQNVELISLEALGQKLEELAAGPSTNKIKRDIENAINDWKILSRDVRNVTAKHMQQKESLNRYEKCKEDAMNVLHSAEENLKNLTYDKENNKLTKDAIIKTLTDLESIWQLKNRDLNAATKELQNNAYYDGNKNLDDDVVKLEQFYAHLTESLHDLRDEIEKKNDIFAHFKEDIQELNKDFRKLINIELEPIARTGEELQKQRNECEKSLELLDDKAKKCEELNERWKELSDNGVINAAGNLMVLNQLDDIKDDINKQQHVLSQRKRKISMMEQSITNNQRFDFSDIDAICGDINDLLSDEMLLGPIKTDINELRSQQESLRQFREKKLRSVGERVQSITDNCENLMKSAEPQVNVGSLEVIKNKLMDLWNDLNGRLDEREKQVCSAIQKVGDYTDTYNSLIIWLQDTEESMANQRQPSIEHKVVKEQAHANDIFLKHIEEKKQSIDGFKAMIDSLGKISTNDSQQKVMKDKSDEIVGRYGKLVEDAYKRRNRLHEALDLTKQWSEVVTPLKVWLEFAEKSLQQLGKVPTEEKQLKEQMDAQKELLNEIERKRPEFDLIIDLYPQLAQFTSVDEAAELEIIAKSFAARFLDLSTRTNECGDLLHQVAEEIYKFLDHTNTLNDWLDNVEDDMDKLESISIYPEELIEQSSFLTELALAVTQQEALVSKVVEDGRELCRQTTGDQAIALQSRIEILRSRYTELASITDTKIAVLSEALPLSERFHDGCEIVQQWMDAVEQDLQDIDQVPLEVQSTLISQIEDDLGKWRLDVDEIGGISKQLQRLCDAPRADELEAQTDDLSRRFSQLADRVTRKAEKLLSAEKQSRQVLDELDYLNEWFADARERLMNASAPAIDPEYVKKQLKNQRQMNEDIAIMKARLRDAAADARKISRALGDEVTGQDSLLATKIESGRNLSADAARMGEDRLADLEQALALCQEVDQSFGELHSWLEKIENEIDNCPTVSTGNQREQLLKQQTHNAELQLLVQSQKPLMDRFQKTVNALKELCDVDDGSQLEKIAEGIEERYEAIKEAIKQRAEALETAIEHTSRFSDRLDVILSNLGGTAAQIRNADSISADPDRIRSQISDNISLMEELKHKEGVLLSVKEQAREIMEKAKLNDTAVDDISAKIEALDHLWLELNGSLSNRGSLLEETLIKAEQFWTELQKCQKAVDDLRCAIEAIQPATGQPSIIEQQKNTLMVIEGEIREHEPLMMQNLRVAGQDLCEVVDAEERSYVEQQIDVAQNNWASITDLFVRKNTDLIDAMEKAMDFHGLLNEILNYLSNMEGKAANLAPVSGINLNEIRDELNKVNELRALLDEKALQKEQLNQLCAGLCVGAQVNHSSAIRMPINDLNSRWNRLYSSLNERQQQMERALLEMGQFSQAYDQLMKWIEKTETVLDEIDPRPRNLKQAEIEICKHKVVQNDILAHEGSVDTLNLAAKRILTADPNSASITQPKIDALNARWHTLVDKLEDIWEQLNESRKAAENLGGEIDKWFLWLQDKDADLSHAKACGGLPETALAQLDDFLVLKAEIEQNRAELNAHIENAEKYLLENFENGDTWVAQREVQLKKKWVQVQEKMIDREQKLRIALADAEELHSSMAVMNEWLSSAETRLGRLQPVSRIPGTLEKQIAEQSSFQSEISVHREFMTDIHSKGTKMQYYCEKKDAIPIKNLLVSMKHRFDKIISRCTDRTKQLNSALQESQIFFSACTDLIEWIDRSTIWLNEQTVQVTSGDRVREALSKHKEFQQELNDKQPIYDSICKKGKSLSEHAPRDEQNSLNEIIENLRKKWSQICSSALQSGEFDEALSSLTECLAKELPILRENEKINVHGDLETVNQLFDAHKSLCEQIESRQSSMESVRRRAEQIFQCKDDTESLKGLQEKLEKLDVDWTEFNTLAKQRSARLEEALNEAKSFDCEVHWILEFLPCIEARVRAKSNIVEDENEILEQMDEIAQIRKQMDDEQSRMDSVLTAGHNIQSKCHPDAEQNMRCWIRILQTRWDEVSQMIDGKRDDLEKHLNELRNQECLIADLLKFISVKDAELKILDTGPLPEDSDVIKRLIDDHENFEMVLREHQPQIDDATKSRKRVETEIKARNSNVFPRRERSIRHPKSEQLSDRWKKLWIDSMDYGRRLREMKEYLDEVKRLESFSFEEWRQRYLEWTDSGKSRISDLFRRIDKSGTGRVPRIAFIDGIIASKFNTTRLEMQKVADVFDKGDGMIDAKEFMSKLRYDYRKKMPSKQKTDGEKISEEVLRQSEQCNCYNPYKIQKVGEGHYRFGDTQIKRMVRILRSTVMVRVGGGWVALDEFLHKHDPCRAKGRTNIDLQRCFYDDVRPEGAYDTMEVFTKTSRLTPNRDTPLLNFSDSLMSTRYNITPGPITKIREKTERSMPMYNPRRASNFSHNSPLITPHSSRRQSDVTHGSQSDIFNISRSDSRCSDISENFERPTRIPSLRGKKGIGYGYSSRTNSQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5I7</accession>
    <name>A0A158Q5I7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS10083</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5I7"/>
    <dbReference type="STRING" id="318479.A0A158Q5I7"/>
    <dbReference type="WBParaSite" id="DME_0000749801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000749801-mRNA-1"/>
        <property type="gene ID" value="DME_0000749801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000749801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40794" checksum="0DFC1B21B722BBAA" modified="2016-06-08" version="1">MSSQSVFKSTWNSLSAFRPRYRPVSNANFSVTGMTMFEKLQKLGEGTYGIVYKARHRQTNRIFAVKKIRTEEDPDGISATALRELVFLRELEHPNILKMFDIVYQSQKLYLIFEYCSMDAKVFLDRLPKNKLLPQVLVKSFMYQLCQAMCFCHQRRILHRDLKPQNMLVTKNGTIKVCDFGLARAVLIPARAYTHEIVTLWYRPPEVIIAESPYTCSVDVWSIGCIFFELASKQALFSGDCEIDQLFRIFKMLRTPTDTEFASLTKKTDFMHAFPKFTDYALPSKALVFLDHEGFDLLEKFLLYNPGNRITCKAALQHSYFNDLDKTDLPAGSWDGSTLMLPPKSFLAEAEQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5K5</accession>
    <name>A0A158Q5K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membralin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1889</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5K5"/>
    <dbReference type="STRING" id="318479.A0A158Q5K5"/>
    <dbReference type="WBParaSite" id="DME_0000762201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000762201-mRNA-1"/>
        <property type="gene ID" value="DME_0000762201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6779347at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000762201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48690" checksum="E1DA3189CBDAA3C5" modified="2016-06-08" version="1">MENGYLHQNGIDENSINGEAVAVAAEENIDARPQPNVQFLDNPNIHPATGNPGIPNNPIPQGEHIPQPQGNNQFGTVRDRLFHAMLVRFAISYNHHVSGFSRRLLEFSVLFFALSLLCLLFYVHFVFSKADNSCLKHLVDSWPRDGVMRIEVISNLEKFNEYQERISEKQRSQKESNASFTFFDLKKILMEGPNALPKELKAKHGETSKKTDHWTNFRLPEETLISLFLKSSKGVKRKLSVEEVHGDEEELLDFIEEDGFYGESLEALFEYVVEYSLHYGLLRLSHSYRVEHNIPFMLVRLDPETDSCFGDWFSRMLMKFFMGYEDVLMASVKALAENETEKGYLRDMITGEHYRFVTMASGNSSYLTATFVLLIFTFAISMLLRFSHHQIFLFIFDLLQMFEMNQALVFPAAPLLTVILALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5N5</accession>
    <name>A0A158Q5N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BPL/LPL catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1996</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5N5"/>
    <dbReference type="STRING" id="318479.A0A158Q5N5"/>
    <dbReference type="WBParaSite" id="DME_0000784501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000784501-mRNA-1"/>
        <property type="gene ID" value="DME_0000784501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="399"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000784501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="664" mass="75136" checksum="6FAB16516171CED5" modified="2016-06-08" version="1">MRGHLVVRYSLLMRYKNDQFSGTKHEEKWINSKFAAKTRIHENRRHSAVPFINIYAGGPPIGIRRRSLSPMAFLPIPVLSDSLSPLFDPEAFHHRSVTPTRRRLFNDASLDKVQSKPPTILVFTGDNDELYHRIHSTLSTMVSPEIYTVFHLSVEALHHHPWINREAVCLIIADTKCLDDVAWLRLQQYFNNSGKMLFLCQNNLLASLSTCGSFHESAKLLKMAFGDRQSNVLGKDFENFIKKAFKSISKYKTVNETFHSKDLVGGLKYSVVIYKNADAPLLLYMENAAHHASALFSDATSEELFESGATLIADALSRLSVQISPKVVIPNLSQGYLICQYDRLPWNIKGMYFNEVFGSFPKLLIKQIEKDGKLPAATNQLLPIEVRTRQQGLPEFDDRMYFRTLRTKRIGAALIYVPVCESTQDIAKSLATAMPNEPIVVVARQQTKGRGRSGNQWLSPIGCAVFSFNFNLPASTLLASNVVFIQYIFSVAIVDGICSLHPHLENLQLKIKWPNDIYYGRMYKMGGLLVNASTIGDKTVCTLGAGFNVANSKPTICVNDVLPINSRIEVKIEEFIANALNKFEDYVNIFQTNGRQDFLKYYYNFWLHSREEVTLAKSNEKVVIRGLDEHGFLVVRSRQSGKIMVVHPDGNTFDMMKGLISVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5R8</accession>
    <name>A0A158Q5R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2186</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5R8"/>
    <dbReference type="STRING" id="318479.A0A158Q5R8"/>
    <dbReference type="WBParaSite" id="DME_0000806101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000806101-mRNA-1"/>
        <property type="gene ID" value="DME_0000806101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6126662at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000806101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="54735" checksum="CB9F08BD61C476B1" modified="2016-06-08" version="1">MSNGIDREIVKGNWLQQKTRKKSGTLLRKKKVMYEEAEWVVLCVHDGHIPFLECPVKVVDLLDSAFVSSVLCDSRSFIVGFSHFSRDAIELVALTTDDCKDWVQKLISTLVRLKCIDDSSNLYSPLQNSDILPSNCTVSSHCLFMNSTLDDEVPLSIAPSLPTVEQSPYEKISLTTNLFSIKKDETKEPPVNHTSAKDTNINRVLPPPIPPRIISSDLRHFCPSYAIKSLSIYDHPKNFAISSFSYDTLDFSNRRYSSSTESSSLSSSVQKVDSDYGAPAENTTLNTFISPPEESKAKCGAKIAGWSSNKDKQISNILHIGDELVEIGGTKVKNLEQLSSLLYSSSALGAPIENVRPGSPAWCAGLRPRIPSGLYSDKESSACITQVNEYNVDIYSKNNSSLLLIFDAISIQSNFIIIAQPHDFIKELQKAANHGKVAATSNGGRAFVWIEKVHPFQITVADHSVIFNSRKYFHGILAAKRLFQNASLSNVRPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q660</accession>
    <name>A0A158Q660_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2905</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000088">
        <property type="protein sequence ID" value="VDN52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q660"/>
    <dbReference type="STRING" id="318479.A0A158Q660"/>
    <dbReference type="WBParaSite" id="DME_0000916801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000916801-mRNA-1"/>
        <property type="gene ID" value="DME_0000916801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF161">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000916801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53511" checksum="9A6DAF3BF5A7A498" modified="2016-06-08" version="1">MAARNELDASTMPSTVIQTLSSSGQYKKRLLQKYNKEQEDIVRNRETLYPCLSNEALSLNNSFEISKPTFDTKNSCSKDDSHKRAILLRQPTIEESFSPSPDSLPLQNLSKFSEAFGSQHQIASWMHNQLLALQKQWFAEPVMPSSNSQLQIPRPCLTVKSPQLLAPPSTHTSRTFLRAVSPQLESTLGPIKHSAIWRRSRSESDVSYDNYICKHCGQAFAVHDRLAKHIASRHRDRSISVTGDETLSKLHKCTVCTKSFGRSDMLTRHMRLHTGIKPYGCHICGQVFSRSDHLSTHQRTHTGEKPYQCPQCNYAASRRDMITRHMKTHIRPGGSPEFSPLAIERLTLGQIQRKSAQSSSSQFKSSQFDFSPSSFQLNSSEQRHDFSQDNISSGLHKSMDNLVILDKSTVNLIGSGLRPSAFTPSVKYNSSKSTISENAFDPNKLLIPCTYFGPHSSPRTSPAITCQSNLFFSSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6D9</accession>
    <name>A0A158Q6D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10757</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001244">
        <property type="protein sequence ID" value="VDN60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A158Q6D9"/>
    <dbReference type="WBParaSite" id="DME_0000982701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000982701-mRNA-1"/>
        <property type="gene ID" value="DME_0000982701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1854"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1946"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="2042"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="2139"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="2243"/>
            <end position="2335"/>
        </location>
    </feature>
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        <location>
            <begin position="2337"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2439"/>
            <end position="2515"/>
        </location>
    </feature>
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        <location>
            <begin position="2524"/>
            <end position="2607"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="2713"/>
            <end position="2809"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="2822"/>
            <end position="2910"/>
        </location>
    </feature>
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        <location>
            <begin position="3257"/>
            <end position="3309"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3314"/>
            <end position="3402"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="3410"/>
            <end position="3485"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="3492"/>
            <end position="3587"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3554"/>
            <end position="3682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1460"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1661"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2897"/>
            <end position="2921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2993"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3057"/>
            <end position="3092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3141"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1681"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="438"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="545"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1174"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1477"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2911"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2995"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3057"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3069"/>
            <end position="3082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3143"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000982701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3715" mass="420748" checksum="1B5EC6EC9B666427" modified="2016-06-08" version="1">MKVKKEKQVKEIGETVKEEAEMAFEMELQKPSSDATLAVILQTAINEATSMKVKKEKQVKEIGETVKEEAEAIEMAFDMELQKPSSDATLAVILQTAINEATSMKVKKEKQFKEIGETVKEEAEMAFEMELQKPSNDATLAVILQTAINEATSIRFRKEKQVKEIGETVKEEAEMAFEMELQKPSNDATLAVILHTAINQATSMKVKKEKQFKEIGETVKEATEMAFEMELQKPSSDATLAVILQTAINEATSMKVKKEKQVKEIGETVKEEAEETEMAFEMELQKPSSDATLAVILQTAINEATSMKVKKEKQVKEIGETVKEEAEMAFEIEDEAKSDEMPSEMPKAETSKLEEFLVKQNDLVDEPVRVEEKQSKKKKKKKEREEVAKIEEVVVEFNLGKPMESETLEAILLQTAFDANLLQIAEDRKDRGKLRRVPQLEEAKSDEMPSEMPKAETSKLEEFLVKQNDLVDEPVRVEEKQSKKKKKKKEREEVAKIEEVVVEFNLGKPIESETLEAILLQTAFDANLLQIAEDRKDRRKLRKVPQLEEAKNDEMPSEVPKAETSKLEEFLVKQNDLVDEPVRVEEKQSKKKKKKKEREEVAKIEEVVVEFNLGKPIESETLEAILLQIAFDASLLQIAEDRKDRRKVPQFDEGKSGEVEIEERGAGDAELLERGLLVMKCEKEEGKKKSDADYVLNGHDIFVDVSLGEIMESELNGSQQTADSLFLLDIEEKKLMQRINKFSPSGEVKIYDACWELPKNEAEVPKLKELAKMKEVVVQLNTAEKGEIAENVEKDRKTYIVAEVYLNKAVLSEGLETSLRRNFSSIFLQIKEAKRLKQKISSIIMEQELEDKTKDDLLQIVDIGRSFSFAMRRTEKIGVGAIFDSEKLNEKISLDEEIIRPSVNGYATTLVKHLHKIFSHIIFYCNQKACELDECFRKETFDNAMFLTIIPTFRFANVSVEFAEPPTIIKLDIPSAYGQDIAISGVDAEIVVAAGEEIATTQAIVDVIVSSFGEAMLKALEILTTILDVDVSLQSLEDEESIEAIGTTSMFQAISLMLQVPSTVATITRSINEKKMRISAENQEISVKETENITELVTLDQNASFEFRTKQKDIIGAENVDMKVYLGVRNTDQTMEHTEEDAQDREVTIKMDDAKVQKELKGLLNAIGVRTAEKEVETDKQTAKPKESRKKHVELSEKQRSTNEKLLKRAEKASKAEIEHEIPQLDESESKYIEIKRNEEKIKPEKDILMDQNRTMQRIEQKKKIPKTLVIPAEISSKYGDKSTLLSETFITTQVTLNEATAEVEAVPSPRPPSATITMKVDSAKNVRSRPSTPKSAIAFTFKEAVESVEERIQKKPKERKDLPPLPKAVAIIEPEPFTELNTMMINEECKTIKNIGFSISQLEKLTFEIKAINKKIKKRKKAEIAQEEISVEEFKNDWKSKDDNLEKNIKLKEKEIKEKKPKEEKAIRKMRKSVAKRMEEKHSEKSITNIKDEADSKVSEAHDEKKSDSQEKKKSPKVQGFDEEKVATVNKREMVKPEKTNVDANKLIKEKPVENAGKEKDQEVKFTNWIEAKEEEVKTVEKVKQQITKMKKTTEIGVEAQFKQLQKKLAAMKILNIPIKAEEKAKETIHEHKIERKELDQKTIEKDEKPGKKKERVPQEKGFDNKIIGHILSKMPELLYEELEISLENATQTNKLKETERTIGKKKSKKNKLDGEIKVPTMVQIEGLQKEIEFDMPSDELQKARILDVEKTNYEVRVRKKRNGFLIPPDQEVFALRDEKIRIECELYNEEDELSWFLNGKPVSDDCRCHEESLGFIRALNISNLIPQDTGSVILARTGDHCCQTILSVEDVPVDIIAKLPRRSFANVGGSVNLSVKTSHAAENVLWFRNGDESPLTQSDSVKIISRNNEHQLIIKNLTYDYAGRYTVKAEDRESSTILEIHGAPTVDETQTSKIELEAGENLILSTNFTAIPEPTVEWLFEGKPLTDNLKVQTEVVQESAHLCKRKASKKDSGIYTVKISNEFGEATTNIFVHVKDVPEAPINPRIIEIAADRVTVAWDMPKDDGGSSIIGYVLEKKESNRRAFHHVAQVSDEETKYILDGLEINSSYVIRVAASNKYGIGEFIEFPAVTSELSLEAPTIENAPVITNIIENGCMLEWQDVTKDGGSPIYGYDVFCRQDNAEWVKLNEELLFTKRYSVTDLIHGSSYEFKIEATNEAGLKSNSNVASESLMLTPSISTSKRKIIPRIIITGPDSATADWDEPELDDDNITSYTIKYKSEKSIMWFEAEVEHPPANISGLKEGVAYVFKVAANNAAGVGEFCEETEPIKVTAKIHPEITKSIKDTSVPRKRELRLECHARGEPTPQYIWYKNGEEIVPINDNIEVINEGYMSILLIHSTTQEDAGDYECKVSNELGVEQCNATVNISEVRAYFQSSFPEFMEVDEDADAFFKCELSDADASILWYKNGRVLEKSDRTIILEKGTERQLIIKCVKPEDSGDYECVTTDGRSKAFGILCVKEDEPHIKQGPQDQTIQKIGENVVLTCEATKPFKTIRWFKNGKKVWPRSDKIIITTHGPISTLEIANFDERDEGEYYAHLERDERSVSAVLQLKVKPELLLPKTLEKKITTNVGADLDFKLNFTGHPVPEIEVTLNDEPLQKNKALIVNYENTISIRLHSLERQDSGILKIIAKNNSGFDQKEIHISVADIPSQPRNLNASKISENSVLLNWDHPANVNGSAVLEYIVERKMAEAGRWRNLAKIKASETRFVANELLADSIYAFRIFAVNSIGKSPPSNEIDVIINTMEILELSEKKNVSRDIVKAPEVKITSERGILIIWPEVSGAKSYRIERMSKHKLSWQCIDIINTTSYEDRSVEFDTIYLFRVITIFNNEFSPPSEPSDEISVPRPVEAKEDEGLSDRKTKKMEEIELENGELEKYLSKTVVSLDQMLEIASNQTEEKSRRKAKKDAKKGKKTKEIVVSKDYITEFTEFDNNERPPKSIKQKQEKKTIVSKKEKKSEQLEEILQDANELQISIQDENLIESKVEKKKNVVQKAKSSGEQFNQADYSKKLEQKVNEGKETRKKVSKEKISGKMAENGTYEANGDYIEEIQPIKEKQDKTRKHHKTEVLVLGEQPTVKKQGVIDKEEDQKVAKDKSNVDDMDSEIKGSDAATDADKAEIVAEKIAEKKSEKTKVSVKKEEEESKNEITDKAISEKSRKATQFLKVTAENTEKILYFNTKAELLANIEGDFERCLWTHNGQLLDEKDIKTSTTTSVLHLNKINEATSGKYICSVENALSKSSVDFHVSVIDAPKIELAARYVELKAGEPLKLFASVTGLPKPDCIWMKDETVLKTKKNFCATYLNDIATLVVDKVDVADSGIYKILARNPFGKCEMDIKVTIKGTPSAPIGPLEILRITNESCHLAWKPPKNDGNSEILGYCIEKRDSQKTTWVFHSRVTEKETDITGLNPTIKYYFRVSAENALAKQEKLLSKPTMKAATEDSITIGWAPVESSGAITYKLEMKESKSKNGWIVVAEEPTVKNYITAKQLKPGMLYEFRVRAINEMGEGSLSPVSEPFQCIAKKDIISMKPPIFTSFIDDTVAMIDEKVKIEIHFDAGTDPEIHWFKNNEEIFPTQRISIEKMSSFSILTIAEMAKDDEGDFQIVVSNEAGSAKHNFSLSLISSPHIFKPELYSKPRIHDKGEYVKLSLKFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P7Y9</accession>
    <name>A0A3P7P7Y9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS1707</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 18"/>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P7Y9"/>
    <dbReference type="STRING" id="318479.A0A3P7P7Y9"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000029">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 18" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN51734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="277" mass="31488" checksum="3DBE3036B16D24F4" modified="2019-02-13" version="1">MSRSSRQMILFYCFNAVLRSASTTSTGGRIKTFEIYRFDPEKPNAKPYLQKYDVNLDACGNMVLDALIKIKNDMDATLTFRRSCREGICGSCAMNIAGENTLACICKIDEDTSKSTKIYPLPHMFVVKDLIPDMNLFYAQYASIQPWLQKKTKINLGEKQLYQTPNERDKLDGLYECILCACCSTSCPSYWWNADKYLGPAVLMQAYRWIIDSRDDYPEKRLERMQDGFSAFKCHTILNCTKTCPKHLDPARAIGKIKMLLTGLSAKPKPVPAPANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PAU5</accession>
    <name>A0A3P7PAU5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disintegrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000084">
        <property type="protein sequence ID" value="VDN52874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PAU5"/>
    <dbReference type="STRING" id="318479.A0A3P7PAU5"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF248">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN UNC-71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="187"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="9">
        <location>
            <begin position="392"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="340"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116289" checksum="03A79E9F7BD71EDC" modified="2019-02-13" version="1">MSTNKEFISRLGDRKFEVVHPFQIRDKNDRIGIDTRNYYLNGSVHYKQVIIVVRTLSVGRLKLLVRLNELIFVNESDFKKFDDVGERLLSQRAENCYYQGSVNGEESSFVALSSCNGLRGIIGFVNGTAYGIWPLDGGDRGRRHPHVFYQTTWTRTANSGTQIKVANNNEFGNNLKIKKRDVTRQTKYIELSVIGTHSFMKEHGYSDIVATEFMLEAVNVADLIFSRELNVRLSVIYSELWIDTNRIDVTVDIERTLSGVIEYVTGHLYHIVKDVTIVFTADKFANNEVSSCAFGSICTSRAAGIITAIDFFTVHDTGQVLAHNLAHSLGIDYDKGICLCEMDQCLMNRQIGSYGSPFIWQFSRCTLARMHGILQTGHLQCLLNRPLEASPLRQCGNGIVDGEEECDCGRRDDCQDPCCDPLTCTLRAHAQCATHQPCCYRCQFRPAGHICRAPRSSCDIAEVCSGDDGNCPSDGYLIDGTVCGLNGHCWKGNCSDMEQQCRNLWGNESTLAVDHCFERNVLGVEYANCGVDAGGGFRKCAPDDIRCGTLQCRGGQQSPLDQSLSSFSLQFLHDSKQIQCKVITNSEAGIVSDGSSCGSSKVCIQGVCLPLLQVSSPVHCPTNNLAYHCSGHGDCTTTQHCLCFVGWSGFACDIRSNTSVSSSTTALSPFDDLFIPLTVGHTLHTTTLLAILLLVGIFLLMLLVCLLFCYRRRSDVEFSSSANEKLNDSIPEIAQRSIKFGNMPSYREEKRKRKKDKRVYDALHRINEASDERDSISLKSRDSASNRIGNESASFNFKASPNLVRNGGAIMLSSHGSQTLILNENSPRHKLLIGCDYYNRSPCSEILASPSRCSVNAHGEIRYDRTHNGYATDSELGMNHYSRYMNNISPQLDLSPSSQASTNRLAPTPLKLNNIGMLLRQLKYTDENTSDSGLGETERINHINWNMNNESSCAALETEENCKMSIRNEEPVEMYNRKHNDDRYDGIVFDNRRAIQCNFSGSSNDSIGKSDTKGINFHQANSLLNEVNKSERQSLFTDSFKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PJ70</accession>
    <name>A0A3P7PJ70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PJ70"/>
    <dbReference type="STRING" id="318479.A0A3P7PJ70"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="222" mass="25200" checksum="50DB5FC2172C8D4D" modified="2019-02-13" version="1">MNFVIFSFFIFDEITGIEGFIFFNAICSFLALALFEAVNALCGTLTELCTPVSCPVMCYPGVPKAHWISERRKHHLYSAMQYIDCVMSFCEKSSKDESLYPTKYGNSFSCNFESHCRRLLQLLWHCCGHLYTNHWEQLSALNLRPQFSLVLAHMHSIAKIYGLMDSKELSIISRTLQVILSFLHSGGHSHSKWSRMPSSKSGSWGGHPSPSIISYKSYAQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PPB3</accession>
    <name>A0A3P7PPB3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PPB3"/>
    <dbReference type="STRING" id="318479.A0A3P7PPB3"/>
    <dbReference type="OrthoDB" id="5855871at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF17">
        <property type="entry name" value="CUTICLIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="237" mass="27629" checksum="F2A8058FD2C13E19" modified="2019-02-13" version="1">METKEWYINIFTTQNSRVNCKAALFNNQKSTCILSMVSINDVNNPRKYFKHDKNFDLYENNCFKSDKERSLQCRFVRMHSSGLTDVFDEKLSGLSDEIKCEKECLNWKHGICQSYIYDKNLKECFLSHATSRSLGRNFITIDDNLSFGELDDCMELQLSCKADGFQLSGWSLKLFNGTFKIKKAKEKHCERFFKDTEPQTVYTAVVMLKEGSTDLITFRDKIIQANHLYKSIIHLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PSC4</accession>
    <name>A0A3P7PSC4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC30/dfy-1/fleer family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PSC4"/>
    <dbReference type="STRING" id="318479.A0A3P7PSC4"/>
    <dbReference type="OrthoDB" id="10249577at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="307" mass="35760" checksum="7CB8773E23F58070" modified="2019-02-13" version="1">METTFQPDITYSIALCHYQMHEYSQALKFIADIIDRGIKDHPELSIGMVTEGMDVRSVGNTLLLHETCLIEASSEALTDMPPRHEEELDPVTLHNQALINMDKNPSDGFAKLQYLLNQNPFPPETFSNLLLLYCKYEVRFSVNRIMYYDLAADILAENGHLTYKYLTQYQRDYLDAIITQQTAPLEAYNKFDALANDQIKELRKLTKKIQDIRQNNEEQTIRNAVDLYDDTMAKYLPVLMSQAKIYWEMSNYAQVEKIFRKSVEFCSEHDVWKLNVAHTLFMQGNKFKEAAGFYEPIVKKNFDNVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUT6</accession>
    <name>A0A3P7PUT6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUT6"/>
    <dbReference type="STRING" id="318479.A0A3P7PUT6"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF329">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="12">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="436" mass="49630" checksum="7C6ECE5245542646" modified="2019-02-13" version="1">MQPSGELDDFTRKKMAEPRCGVPDLYAIRQPGTIFKWNKKTLSYSIQSYSGSLSYKDTKSAISKAFELWAEVIPMDFNELPRNGDIRIKFAKRSHGDPWPFDGKGGVLAHATMPPSGLLHLDDEEKWTYMDAQKIFRYDYTDLLAVAAHEIGHTLGLEHSRNKDSIMAPYYQETVDRRGNYILPKLHYNDISMVQEIYGTSFWDRIKSFFGFGGKEKASSNASSRQPNTATTPIPPTSLRFGGKDNRTPKDPVECPHDVDAITKVGDEVYLFSSSKVFEIINQKVQQIYSLRKLFPNSPPYVQAALSNPASRSIILFQGRQVESQSPAKFSLVRPYPKRLSSTITFNPMGAFTWIDGRKVLVNALDFAIYDDYWNQATMQDRIAKYFDNFPREPIRGIIVEDNNISLFTNDKVYKYDAKRRNLIGGPVALSVYLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXC9</accession>
    <name>A0A3P7PXC9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXC9"/>
    <dbReference type="STRING" id="318479.A0A3P7PXC9"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000052">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="573"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="97707" checksum="5CF8757CB75FD3D1" modified="2019-02-13" version="1">MQIEQRTIGGTTKRRYWFAVAEDSPYLYWYKNKGDVKCLGRLCLSGAAFTFDPRETGRFEIHVGDEEHILETNDNKSRIQWLQQLQKNRRHHFDKNDSCALNIEIVSLSSHSLTDENSQENAPGSPNIESAEDVAHNSPDNQSLGNESVETQSQFYLDCEGELNDKSLEMPLSDGSGIDLLRSIEAFLEKIVDETHTKGKNLEEPAKRVFGKAKASLGSLTHSSSGKQSCAQCKALIEIINNLKERCYELTDELIANRELGSVLRQNVLRANRQIDTLKRLTELKDSSDRIDFILERECLLTAAQMNSVMYSRQVETLKQQNRKLDEQNEALRIEIEAFRESVRSKEALIVKMCEEGTKLVPEGILIDSAGMKCDESMKRIFDEASVCDINEMRDLVEGYRKQNMFLNQEVLDLQKVIKLLEEREKRAVRRNFDIEACYYQMKSRYITVLNHFKTENANNHVLEPGVIEALIDETDFATNNRVPGRSTNEIRLTDSLGFYLTDAKKRPLLQSGDVLDLAAELKSMSDQIIGRRDMERSPQYIDWLLKWDSFLVNNVSRPLKPSSELKSLIRNGVPKTYRKRVWKRLIFFALLVMHLVGDQKSDLGNGYFELLLRKARRMEEREEYDGAMKQIELDLSRTLPTNKYFDEPTSEKIGVLRKVLFAYRFHNKTVGYCQGLNRLAAIALLFLDDCDAFWFLVACVEYLQPPDYYTPSLSCAVADQKVLRDLVGEKLPRLSSHLKKLEVDLSAFTLSWFLTCFVDVLPQTIYLPIFDVFLYEGNKVLFRFALAILKLAESVILECKTIGAVHASLSNIAQYVDDFRSLAEVAFNGLSSFPMKGIEAKRQFYISQVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7S637</accession>
    <name>A0A3P7S637_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7S637"/>
    <dbReference type="STRING" id="318479.A0A3P7S637"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000007">
        <property type="entry name" value="Transcription factor SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="151" mass="17513" checksum="396A15D1BD6ABDE3" modified="2019-02-13" version="1">MPNVAKNSPTPYTDATNCKKSSNHIKRPMNAFMVWSQMERRKICETQPDMHNAEISKQLGKQWKDLPEEQKQPFIQEAERLRQLHMKEYPDYKYKPKKKPKKGTENATNTQITGPTNRQPNNTQSINGSRMKTSKRSPNQLLIPSATIVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SK18</accession>
    <name>A0A3P7SK18_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SK18"/>
    <dbReference type="STRING" id="318479.A0A3P7SK18"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="339" mass="39356" checksum="89DFA606F403801A" modified="2019-02-13" version="1">MKDRFIFGEAGLQLFRSKIKATAHCTIYLGIYFLAISSNTEIDDDIGEGVIVHRGVMMQLIDNENHIGIADEIESYPCRYCADRVFLTPFGLEKHTKALHCEHLDKVFKQITKIHNEWRRLVKSSLKDVFGRKTGLLYPNIRRTYDPCRICGILINILHPSAMINHMRAHTKNDELRNQLLAEYGVEYVERVTCNECQLVFSDDNKLLAHTEFTHARKRKYICKWCGHLCQSMGLLNAHKADVHGMPSTRFRERMRKLNRRKAVGETAGSSFFSFRTACEFCDLIMVKPSLLIRHMLRVHNRSIFTAVIEMKKTPPVKVEVDNGRLTWLCCESSYYDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0E7</accession>
    <name>A0A0N4U0E7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4378</name>
        <name evidence="2" type="ORF">DME_LOCUS4383</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0E7"/>
    <dbReference type="WBParaSite" id="DME_0000001801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000001801-mRNA-1"/>
        <property type="gene ID" value="DME_0000001801"/>
    </dbReference>
    <dbReference type="WBParaSite" id="DME_0000002301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000002301-mRNA-1"/>
        <property type="gene ID" value="DME_0000002301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865326at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000001801-mRNA-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000002301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11851" checksum="A01BC1346FA3C0C2" modified="2015-12-09" version="1">MSETAGRIGLRINVNKTKDFSPYVQEADKMPLFVNSLPVEEVPDFKYLGSTLIPNGQAKDDITTRITAARKAFFRLTKPLWSHHKNESPHLYCHDPFDLTVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0L2</accession>
    <name>A0A0N4U0L2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CIA30 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4457</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0L2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0L2"/>
    <dbReference type="WBParaSite" id="DME_0000009701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000009701-mRNA-1"/>
        <property type="gene ID" value="DME_0000009701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="88"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000009701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31364" checksum="4F5E0C5CAFBEF671" modified="2015-12-09" version="1">MEAASAKTGLFRRPMNPLNISFPNKYFIEGYDPEMELSEILKEAPAFYKDNLKVMAKEAMGLFDLEKKELFENCGMLSQGEARKEYCFDNPEALKLWRMACDSDWNQGYSNCELDGKSERAGWAGIKLDDRGSFRRKKYFSRWKSFTHLLIKCRGDGRTYKVMLYCPLSMDITWGDTWSYPLHTHGGPYWQYEKIPFSRFFHTVYGRIQDRQYPVDLRLASSIGIVIMDRINGAFALELDYIGVCYDHAHKEKFAYETYTAPICYTIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0U2</accession>
    <name>A0A0N4U0U2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4546</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0U2"/>
    <dbReference type="WBParaSite" id="DME_0000018601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000018601-mRNA-1"/>
        <property type="gene ID" value="DME_0000018601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5779735at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000018601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37217" checksum="D68139289AD47D37" modified="2015-12-09" version="1">MDIQRLQVTHPSYTDVPKRWLAFEEIARVLTDEEVAFTSDMIKLAWKNMMDYYNQIRRRYDRAIAAGLNPPESKWQFYHMMHFTRQDKPPVKRKYNWMQPSKIPRSGESFVEESTNATPPAAVRDANASFNQPCDYSPNFQLPSIRDGSEMNTNIVNSRRLIIRSHTKQPERMRLETRRGALRDSNHDLMGEQQYMNRSSVRKREYGDDSDSSFDEFESSTIPWSSGVVANHEMPSGGVRKSARLLNAKRIVVRKSIPAHFTESKEKPIAALDSTSSFARRIAARLYIIKDLCPSRYLSLCYAIDEAIKEEERELNIVPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U187</accession>
    <name>A0A0N4U187_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4712</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U187"/>
    <dbReference type="WBParaSite" id="DME_0000035201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000035201-mRNA-1"/>
        <property type="gene ID" value="DME_0000035201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000035201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16012" checksum="508977DC69364BF7" modified="2015-12-09" version="1">MSVPKQYFVPSSEVVTSIVLPTIVFCIAMVIAMLIGINKCKQWELDKIVEMRRTRRIVQRITARLREKNFRTIQRARTMRQRKRSFIGAQSSIATPMNGEAPPSYSINGQLNIGVSPPPSYEDALLDAYYNECMISPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U233</accession>
    <name>A0A0N4U233_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5068</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U233"/>
    <dbReference type="STRING" id="318479.A0A0N4U233"/>
    <dbReference type="WBParaSite" id="DME_0000070801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000070801-mRNA-1"/>
        <property type="gene ID" value="DME_0000070801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="600" mass="62758" checksum="50CCA25A4CA69543" modified="2015-12-09" version="1">MCATIAGLVFAPGLTSAVQYNPATVPQYNPVVQASTVCKYTQCSSSNPCAQGVCNNGYCCGPSISENPGAPIMMAPPNCPGCAPQSQPIAGFSPSYNPSYGPSYNPQVLNQQQQQYQCTPGCPRGYSGCCGTQQPSCCPQQICPGGMPSTGRFCYNTCPLGEVCIAGICCPQTIVISCSASVSKSCPYGSAPNGQCYNGYCRAGYQCNQQSGMCCPVPQQQYVCPMGGMPYGQCVTNRCAPGLACIRGIICCPVMPVTTAATTTANPLLCSDGTQAAGICINGMCGFGYSCVKGLCCNKTSQAPKCLDGTEAVGACINGACGKGYQCTTGNICCPATGGPGKRISVTTTVAPPFSCKNLNNAIGPCVGGQCPDAGFMCDSSVNTCCPVVEPIGPCLEPGNLCPLGYKCYTGGNTPVCYLTCNGKGASLGNPPCAAGTVETFGDCCAANRVMQNPYISSYQPPYQQPYQQSYQQSYQPYSNMRGYYNVMLDDLLINCGNKKYKLRKLLFLKRHLSLVMRSGVGVCPDGSEAVSGCINGLCGAGFECNMGLCCRPSQYIDYGGYMLQDSAISNDDAGIKALAKGHKNEKETHKSDKITKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U293</accession>
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        <submittedName>
            <fullName evidence="11">ARID domain-containing protein</fullName>
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        <name evidence="8" type="ORF">DME_LOCUS5141</name>
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        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDN55168.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
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        <property type="entry name" value="ARID_dom_sf"/>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
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            <begin position="259"/>
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        </location>
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    </feature>
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        </location>
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        <location>
            <begin position="1114"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
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            <dbReference type="EMBL" id="VDN55168.1"/>
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            <dbReference type="Proteomes" id="UP000038040"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000078101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1260" mass="142422" checksum="D2D5F020B717BC0D" modified="2015-12-09" version="1">MKWVLKSVKKKSKVLQSNLSQKNEALDENLEFKSPKKIQKGKMESLVQSEDGTMSSLSKANPSKGQSKKTDKKRQQEKISGEPKFCKRSKFDKTKDDWTVGDVVAAYGDCSRKGKWTPAIIVSANALKASMKEALAVDEDDIILRSFRDSKYFCSEPNTLLPLEANAVKSSEVFSKIALDRANPVFLGLLPAGWEHHQIFGGDKTNLKPKSESSFSHKKVAASNKKEMPRRQKAKEVKRKAVSSESSSYEESSEGEEYGAERDQFTAQLYKFHEERGTPINKAPILGGKDIDMFRLHNVVQMYGGKKKVTEHSKWKKVLCRMRLEGCPGATPIAVKNAYSRYLDHFNSFYRNLGLSDWPTHSTSSRSVRLPRPTDREIERYHRKKENIKKKDKKTLEAGGKTVKDKRRLSKLGKEKEGKKQNMKGKKLSDIRREKKQSASSESSEYSKLVSTTDKLNATSNSKQWENKDINVENEGKLKEEIIAYEEKSYSDRGKSEEISELRSRRRRKTSENIEELLKKVCKSPQKPSKNLGFSERKRRRKNSDDCVVKPISEKKRKMIRNLRIKKEPTMSFEDSDDEGGTQLSRHSGRKKQSGRARSTLSPSSISSGQTKYSELSREGVNRSKTRDIDMIEKKEADFVAVTPLTRFSIGQDVLAYHNGNWYGARIVKVEYQAGIEDIVVLLSEYEERKKETDGNADSVRNTAEIWLNCQLESQLENTNCFLHYLGWNPRYDESVNCSRIRVLRKDWNSSLCMFKKYALDTISVDTINLAAEWRSGDTFQSTRIKPTNSTDQSKTRTRRISASHYERQATKIEQIETISRARSQSNASIGSKVRSDITPSRSTPSPKISAFAPSKAVASSELADTVTSFNMLSTCELESSTQSSAATIPACSYEELDIAAVGKTSLLPNSECISYSARYSDSDVQLNVDPSKMLFSDDSFTAQNALIEEESSNKIAENMDSNSSEASASITCCASFVRKADHCCSTIIYPYFSSFTEEIYEHSQGNFYISSHSAAQLSIKSKNESHRSKDHPKSIVVPEIHQVPQEILESLSQKFDENEVATVSSVASGVFKLEEKLRGSSSASTGVTDDLQSGEVPAGEIDDDQAVGISHSRFQRHKSVRGGTRRKRYKNRRSSLSDKKNVKCGRNSENTFDSDEDSESDIEGCTTTRDNLHALKIRIQQQIGDEMLEEAALSMGLPGIDITASHEVKIIQYLERMQKIRELYVEAKAKQVRLDRRFQQRERERKKEGNISHYDDPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U331</accession>
    <name>A0A0N4U331_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5480</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U331"/>
    <dbReference type="STRING" id="318479.A0A0N4U331"/>
    <dbReference type="WBParaSite" id="DME_0000112001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000112001-mRNA-1"/>
        <property type="gene ID" value="DME_0000112001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22770">
        <property type="entry name" value="OTU_OTUD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000112001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40430" checksum="85894E6105AE3F42" modified="2015-12-09" version="1">MAKKKEYSLIDGSAKAHNQNVHNHIHNHIHNHSTNDLSNNKQNNKRKLAVHKQKELTFSYCLLQSPAAGSSNRNVYDVSELRAQLGSYGLTVRDIPGDGNCLFRALGDQLDGHTLNHLKHRLETVRYMIAHRAHFEPFLDVPFDRYVDELSRPGTYAGQDALVAFARLHKVNILIHQLNRPVWQIQGCENENAPELHLSYHNGEHYSSVRRFGDFDNTPAGIRILAKTTTVPCCASHNSVCTAATPVTSFADLSSVQNSFMKPPAQSVLLDSTTIDYLGNDEFELLIRQVMMESGCRDREMVTDVLVDKGGDVIQAIDYLVSLTFYIDQPNNEQLTGIFDVKEMKSLHLFFAFFLICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3A3</accession>
    <name>A0A0N4U3A3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoenolpyruvate--protein phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5562</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3A3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3A3"/>
    <dbReference type="WBParaSite" id="DME_0000120201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000120201-mRNA-1"/>
        <property type="gene ID" value="DME_0000120201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174:SF0">
        <property type="entry name" value="HD PHOSPHOHYDROLASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000120201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16270" checksum="A361DB1FCCA736AF" modified="2015-12-09" version="1">VIHVPKSVENAEKNAQLLREFASETTFDSENYVANLILESGKNCTEAHLTSGAFGADDLHYVLDFDMAFLGANADIYDAHLENIRKEYSFLSDDEYKEQRLKILKLFMQIPNIFATKEMKERFEKKARENIAREIAKLSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U454</accession>
    <name>A0A0N4U454_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5908</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U454"/>
    <dbReference type="STRING" id="318479.A0A0N4U454"/>
    <dbReference type="WBParaSite" id="DME_0000154801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000154801-mRNA-1"/>
        <property type="gene ID" value="DME_0000154801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837780at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493:SF6">
        <property type="entry name" value="DUF4789 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7808" evidence="1">
        <location>
            <begin position="31"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000154801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17894" checksum="4230B9FA6DA05E33" modified="2015-12-09" version="1">MLFIWGYRISISSQSIFAYFRLTIDCSSITETDQCLLVARNAKISRDPKKYKCRREPMPQNEWNKLARNSPTRLACPIGCEPNADLSVSLSVLVKTPKNNPSCQKYYTYGKYRDQKEGEWYLWLTDPCRTNITTWCRFKDIPFYVHKEKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4A8</accession>
    <name>A0A0N4U4A8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps4_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5967</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4A8"/>
    <dbReference type="WBParaSite" id="DME_0000160701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000160701-mRNA-1"/>
        <property type="gene ID" value="DME_0000160701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000160701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7965" checksum="9E570311F1E1CA49" modified="2015-12-09" version="1">MEFTDAPVVLTPPPSRAGPLDTVSEYEEIESNFIHFYRSASISSALRDINSDEGMEHFTEVDVQDADMREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4Y3</accession>
    <name>A0A0N4U4Y3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6237</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4Y3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4Y3"/>
    <dbReference type="WBParaSite" id="DME_0000187701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000187701-mRNA-1"/>
        <property type="gene ID" value="DME_0000187701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976732at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230038" evidence="9">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000187701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24951" checksum="477DFF35F604897C" modified="2015-12-09" version="1">MLNMVQLQPVILAFLIFSESGNADEVSFTLIVPAGKIECFYHSVTYEHYQSFELDYMVLCFIFVVKGGENDITFYSESPLGNRIITELRVELNDTRNGYGDYKFCFDNSFSIQTAKHIFFDFYLMDSYGQFLGDFNKKFNVEADILRNLDMHIDNFQTVTTSVKNNLNAIERIQRHYSSSEILDRSILERSFEMINFWSFIHLITMLFAASVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U538</accession>
    <name>A0A0N4U538_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6302</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U538"/>
    <dbReference type="STRING" id="318479.A0A0N4U538"/>
    <dbReference type="WBParaSite" id="DME_0000194201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000194201-mRNA-1"/>
        <property type="gene ID" value="DME_0000194201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841698at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000194201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27485" checksum="C6551595804AD162" modified="2015-12-09" version="1">MTVIFHPISLLSITVSVWILLVITFDRYLALSRPLQHRVHDSSQRALLISISLIILAFLFSLPSAFELHLSKGCFGNKSVLIATPTDLRLNENYIFFYLITMNMLFITVGPFIFITILSFQMIYIITNSRLLFQEIKIRRETANKYSTASERTTKMLIIVALKFLICKSPLILVNIWERISGSEVATGAIYQLCVELSNLLVVTNSASDSIVYFRWHLIKGQKIPQIKKDRERALCLIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U582</accession>
    <name>A0A0N4U582_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synapsin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6352</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synapsin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U582"/>
    <dbReference type="STRING" id="318479.A0A0N4U582"/>
    <dbReference type="WBParaSite" id="DME_0000199201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000199201-mRNA-1"/>
        <property type="gene ID" value="DME_0000199201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000059">
        <property type="entry name" value="Synapsin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001359">
        <property type="entry name" value="Synapsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020898">
        <property type="entry name" value="Synapsin_ATP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF17">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02750">
        <property type="entry name" value="Synapsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01368">
        <property type="entry name" value="SYNAPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Synapsin ATP-binding" evidence="6">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000199201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23725" checksum="3C2BAF4AF9B9EE0B" modified="2015-12-09" version="1">MKIDDEQQLVELEGIIRTSGCREVVVEQYVETKYDVHLQKIGNECKAFIRKSIRNNWKSNAGSAMLEQITLTSRHKQWLNIISEAFGGLEMFGVDILVSKDGREFINDVNDTLTLLGESQDDDRRTIADLIQTHIIDTLRTDRRSVANGVENMQYMVRDKTTGQPSQTVQNASSNKPTRQPSLKDNEPPYQDDTMGQLKRTFAGIFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5T8</accession>
    <name>A0A0N4U5T8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GuKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6597</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5T8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5T8"/>
    <dbReference type="WBParaSite" id="DME_0000223701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000223701-mRNA-1"/>
        <property type="gene ID" value="DME_0000223701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase/L-type calcium channel beta subunit" evidence="2">
        <location>
            <begin position="159"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000223701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40520" checksum="13023BBA25DBC6BC" modified="2015-12-09" version="1">MHSLIRQHLQHYLFSYKESRHDIEDPLSYSNNTKLNNQIRTRQHEEQAVQQLQNAKHKPVAFAIRTNIAYDGQLDEDSPMKGTVISFEVRAFLHINEKFNNDWWIGRLVKDGSEIGFVPSPAKLESAQEQRCRKIFKTAKIKELFHPRAITAPYDIVPIMRPLCLIGPSLKGFQVTDMMQKAIFDFLKQRFCGRITITRVNADISLARSPSRSSNKGDIEFTKVTDDVQLEIDRIFELGRRMQIVVIDCDLINYPMQLSNSILAPLIVFVRISNAKVLHELIKSRGKTQMRFLKLQLSAMEKLVSCPDSQYDLIIDENRIDKACEQLANFLEIYWRATHPIDEKSDSNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6K7</accession>
    <name>A0A0N4U6K7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6923</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6K7"/>
    <dbReference type="STRING" id="318479.A0A0N4U6K7"/>
    <dbReference type="WBParaSite" id="DME_0000256301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000256301-mRNA-1"/>
        <property type="gene ID" value="DME_0000256301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000256301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20481" checksum="D7B557E502CF5805" modified="2015-12-09" version="1">GQNSTRRFERRYHTSDGIDVTKPKAAVSLPPSILKRFSWNVSSAVGGSSRKISNRMNEQQNRRHSQSTVTSSESFSSSTSGFSTASSFLDGSTLTDDSSPNNSPDVHISTVTIGEQRTFSSNFDSSRTLRINFGEDNENLDENASQIPPPLPGVPPPSLKKEKKPQHRKQQELMKFILDNHLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U718</accession>
    <name>A0A0N4U718_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7116</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U718"/>
    <dbReference type="WBParaSite" id="DME_0000275601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000275601-mRNA-1"/>
        <property type="gene ID" value="DME_0000275601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771705at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230506" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000275601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11822" checksum="17FD7EA383BE51C2" modified="2015-12-09" version="1">MHQLLLLLLVVSVFYVISFEDESKVVCQYRENEPKYQPNIYLCSKGYSCCKAYGRFACCANDLNIKIMLEILKSLLQNYHALIINLCKYIYELENVKTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U739</accession>
    <name>A0A0N4U739_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS13</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U739"/>
    <dbReference type="STRING" id="318479.A0A0N4U739"/>
    <dbReference type="WBParaSite" id="DME_0000278401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000278401-mRNA-1"/>
        <property type="gene ID" value="DME_0000278401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14336">
        <property type="entry name" value="UBA_AID_AMPKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000055">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000136">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000020">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000278401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62111" checksum="60994F5DA8008D5E" modified="2015-12-09" version="1">MASTELTKQDREAKPQIKIGHYILHQTLGVGTFGKVKVGIHEATNYKVAVKILNRQKIKTLDVVGKIRREIQNLSLFRHPHIIRLYQVISTPTDIFMMMEYVAGGELFDYIVKRGKLKTPEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDDKNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPDHLEKPLVNLLLHMLQVDPMKRATIKDVIQHEWFQKDLPAYLFPPINESEASIVDIEAVKEVTRRYGVLEEDVTNALLGDDPHHHLSIAYNLIVDNKRIADETAKLSIEEFYQVSPIAKIHPSDLPHRHPERMSASNKIAPNLETISTGQKSPHVKRAKWHLGIRSQSRPEDIMYEVFRAMKNLDFEWKILNPYHVIVRKKPENPTYEPPKMSLQLYQVDQKSYLLDFKSLVDEETAGSANSSRHASVSTPVRPSFRGSRAQSLPMPMEALQVDQQTPPPSPTVTKQSQTMQFFEMCASLIGTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7R1</accession>
    <name>A0A0N4U7R1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7193</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7R1"/>
    <dbReference type="WBParaSite" id="DME_0000303401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303401-mRNA-1"/>
        <property type="gene ID" value="DME_0000303401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870436at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10222" checksum="1565BE5D80CB96A9" modified="2015-12-09" version="1">MAFADKSTFIPVEALEAFGNHPAELQIDIDDYFMGTQTNSETRRAQESTEQMELSKASLEETFKEKKITYKKPKIYQRVYAHKESNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8V5</accession>
    <name>A0A0N4U8V5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7498</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8V5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8V5"/>
    <dbReference type="WBParaSite" id="DME_0000349301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000349301-mRNA-1"/>
        <property type="gene ID" value="DME_0000349301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF376">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1203">Blood coagulation cascade inhibiting toxin</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232708" evidence="8">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000349301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14670" checksum="201E040B88FA08F4" modified="2015-12-09" version="1">MVPKMFNALIILNAVFLATTYQIESFGCMAIICSPPKICKVIDEIAQCVLQNSSISPPVSAKMPPPADRIFYPAPLFCDLPPLTGQCSKSRILWFYNSEIGRCERFTYSGCGNRNRFFSRTQCERTCQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9R2</accession>
    <name>A0A0N4U9R2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fringe glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7846</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9R2"/>
    <dbReference type="STRING" id="318479.A0A0N4U9R2"/>
    <dbReference type="WBParaSite" id="DME_0000384101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384101-mRNA-1"/>
        <property type="gene ID" value="DME_0000384101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25491" checksum="A2455C3F6512C08B" modified="2015-12-09" version="1">MVDFQVSNAQIFFITDAIDENLNLSTNFKALLSSCGNEHTRENLCCKMNSELELFVSHLPSWACHFDDDNYVNVMMLEKKLKEFNPKFDWYLGKPSVAEPIFVHNSYEKVGFQFATGGAGFCLSQSLLIKMRTYLRNSGFELLGNYLGLPDDVTLGYLIEHLLNVKLTVIDEFHSHLEPLNISLSGGSYDSDGKNLIDVPLKFSSATDPHRFRSIHCYITGRNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9V3</accession>
    <name>A0A0N4U9V3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7896</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH2B adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9V3"/>
    <dbReference type="STRING" id="318479.A0A0N4U9V3"/>
    <dbReference type="WBParaSite" id="DME_0000389101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000389101-mRNA-1"/>
        <property type="gene ID" value="DME_0000389101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10047184at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036290">
        <property type="entry name" value="Phe_ZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030523">
        <property type="entry name" value="SH2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10872:SF2">
        <property type="entry name" value="LNK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10872">
        <property type="entry name" value="SH2B ADAPTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109805">
        <property type="entry name" value="Phenylalanine zipper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="290"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000389101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55158" checksum="E68FAC023809EE02" modified="2016-06-08" version="2">MPIFFFFKVLAAHESERWRQFCIQYAKSIAFNFAESWQQFISNCESSGRLNIHRDDVVEQFTRTISEELNERLGLGMGSSCSILPIRHRENEKSWRSWSGHGRPASIAETGCLPRSRSEILPCEIASQFEASQQSVAASRKSKRFSWFRSRFPVKTAVESNRAKSGIFCMLIMEIREATPLEFEDSNEKIFAIRGYNQDEYVIETKNHSECQEWISAIRDCITILDCDLARKVMRHPSAPPMGSDFASTSHFCSTRSLNNVHFMMCSQPCNSRFLPSMHALPPGLEMYPWFHARLSRNLSTRLVLHNGVGGHGLFLVRQSETRPGEFVLTFNCQGKAKHVRILVKTNGECRIHQMIFDTMIDLLEYFRANPLPLEDISNPPMLLNEFVICWRRRSLAPDLDVRDFLTYAGSVRLDIRALEELARHEQLNRHHRTFSTVLPNAYLSCLAKTIINALLLVYFAGFAIQLQIIVKLPQLIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9W5</accession>
    <name>A0A0N4U9W5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7910</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9W5"/>
    <dbReference type="WBParaSite" id="DME_0000390501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000390501-mRNA-1"/>
        <property type="gene ID" value="DME_0000390501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231386" evidence="2">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000390501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11819" checksum="5F7315202B29AD13" modified="2015-12-09" version="1">MRFLIVFIAMCFIVSDAMVVSRAMNNGTFCDVCEKFIGDVRDHMQKVGECTRKQLEKWCAKKTNNDIVQQICDAAIKADEDFLKWLKENMEPYDVCAKMHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB19</accession>
    <name>A0A0N4UB19_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8261</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB19"/>
    <dbReference type="STRING" id="318479.A0A0N4UB19"/>
    <dbReference type="WBParaSite" id="DME_0000437801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000437801-mRNA-1"/>
        <property type="gene ID" value="DME_0000437801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866586at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000437801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15031" checksum="EB424DFED5F434BA" modified="2015-12-09" version="1">MRNLEHGDIDVGKKKERAITGVRMSGVGPLIAASPTRHNDPNMATIQPIEISQFAQNPALWPNIESMEQHAIAPHTAHPHRMQHHQFPQMLSQPYTEINGDVNGYGVANQYGVNMEHELDFSPHVNASEMSSSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB65</accession>
    <name>A0A0N4UB65_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8311</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB65"/>
    <dbReference type="STRING" id="318479.A0A0N4UB65"/>
    <dbReference type="WBParaSite" id="DME_0000442801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000442801-mRNA-1"/>
        <property type="gene ID" value="DME_0000442801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="12"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000442801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40353" checksum="6BF556B5436F7E6A" modified="2015-12-09" version="1">MMNFENISGFDKIKAFIRSRLWFSYRKNFQPIGGNGPTTDQGWGCMLRCGQMLLGQALIVLHLGSDWLWQTDPRNRTYMRILKMFQDKKECNFSIHQIAQMGVSEGKQIGEWFGPNTVAQVLKKLVVYDRWSRIAVHIALDNVLIMSDVMTIAHLKPPIELLNLNGNEWRPLLLIVPLRLGLTTINRCYLPAIQEFFKLPHSLGIIGGRPNHALYFIGIAGDRMIYLDPHVCQDYADLDKLHLETIQLTTEPFEDSTYHCPFIMNMPYENLDPSLALAFICKTEKELSDLWRLLKENLLVASSPPLFELLETRPKGFPKFIPYFGEKVVIKGYTDLGDVYDSYDEFEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBI7</accession>
    <name>A0A0N4UBI7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBI7"/>
    <dbReference type="WBParaSite" id="DME_0000456701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000456701-mRNA-1"/>
        <property type="gene ID" value="DME_0000456701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000456701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35118" checksum="5ADC05EC9E1792FB" modified="2015-12-09" version="1">MANVTTRFFADVSSCVKLQRACDIVSTLNDRIDISLDSARQVREGLEIIEDWFSKYHTNYTRFLRLAVPNEQYYSLDHKYIDSSYDVLIQYIVCGFGNLIKCMEKHEQRGLTQDFSVQKIHCGYKAIIIFRDQYLSVLLQFIITTIYGKEIISGKKNYPLQANNNPFTQKNNKEISNLFENEEKSFSLIDDNKKSFTCSRSFSIVDDNKSDNEINKSNELESDLIEDRGNINELEPTKIDERSLPLFFFDNIETGDEISPQNENNFGILYPSMFANQSIMVIRQAWDAYIKTLEQKVRISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBS2</accession>
    <name>A0A0N4UBS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8558</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBS2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBS2"/>
    <dbReference type="WBParaSite" id="DME_0000467501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000467501-mRNA-1"/>
        <property type="gene ID" value="DME_0000467501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21762">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000467501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="850" mass="95369" checksum="018E8BB8F60FE33F" modified="2015-12-09" version="1">MFIGHPILDEIRQGIPLKPTKTIDKSAPMIVIEGESLNNIRRTPIVQQEESFSENDEMKYAKKETSIPSPRPFSSPLYVSECSDKTKQINPALLKLGGKQVVDRDLLLRSIRQGVQLRKVITNDRSGPFIDENSYRYLGKTSNENYQDEADSSRYNRPNSSTSFEEQKHQLASSSLSSNTELNSSLANSSDMTIKRSQYQKNFRPSIKSPNQQIIDREALLKSIRAGVKLRKVNLDDITSPTLRNYLNLNQSSSSDVNENQNALETIHSSSNESFLSTKPQSLIKQQFCDLSESSPDNKNIQSNQFLKEDKTKKADERYTSPIPTREMIESEIPTGSAVNRIKLLNSLQNRSQIQNSNIKSTAKFHENSNSKLNNQFNIFNDSQKNISKTLPWINRNSSANKSGFNNIKLMAQKFNQTSEINNNFTDSTHVKQRRSSLLNESCNKNIAKNISKFEKISTQNDEMIKKTNDRSLSPLATCPQAISSTRSFTPPAISSISSTNHAFQNHSNFDNNSIPKSVSNSKRNNSFTKGSVRNNNVSSISDRDNWKKTQNIPVEKPITNFAINYARPIEIITDDIPPPIPTTLPPQMKNSFINKSLQSLSTTRSGNGPYLFRRKSDNVLSDLTYESPQTDQSFYSPANSSQSNNTTQSSYHSPLSNNSISPTTSDHNFSENRSPNSKCEAVKSQSVNPNRFTIVSNARIKQYGSLENNDDDGDDADNSDDKRTSAISNPNSHGDNQSNSQSVNMSGTKIYSVPINAPWYRPWINGGIIINSNNNNINKTSNHKNSNDVINRALVGHQGIGRAHKVVIGMKNTNDNNIPFTNENPELIQENYKFAIDLNNDKPLTIVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBU3</accession>
    <name>A0A0N4UBU3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8580</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBU3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBU3"/>
    <dbReference type="WBParaSite" id="DME_0000469701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000469701-mRNA-1"/>
        <property type="gene ID" value="DME_0000469701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000469701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20934" checksum="07B44A7896B88A69" modified="2015-12-09" version="1">MDESDSNFNGTAPPQHLLSDYIEMAYLIIVIILGTPLNIYILIKLFKKLQKSGSDAIKIGFLILKINLNISDLLILLLLAFGKLCWLATYEWKANELACKIFNFLSMLTLYISSNIVVCIALDRFRNVLSASKIRRKSNFVRIIVTVSWILALLWSIPQLYVWETVNVYPEWPGGWIQCSDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBW6</accession>
    <name>A0A0N4UBW6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8607</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBW6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBW6"/>
    <dbReference type="WBParaSite" id="DME_0000472401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472401-mRNA-1"/>
        <property type="gene ID" value="DME_0000472401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF120">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00059808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13851" checksum="082531BD4618FBD2" modified="2015-12-09" version="1">MSIDERFQAAVNIVQKLPKEGPLKTTNDQKLLFYSLYKQACNGRINSPQPSIFNFVERAKWNSWNELGDMAQNDAKIKYIEALQNIFDEAAGTINILEWLTNTINDPNLSKNFELIGRSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC68</accession>
    <name>A0A0N4UC68_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spc7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8731</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC68"/>
    <dbReference type="WBParaSite" id="DME_0000484801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000484801-mRNA-1"/>
        <property type="gene ID" value="DME_0000484801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000484801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54890" checksum="71076BACB5891FBD" modified="2016-06-08" version="2">MEENSNITEFNESVEITQLSNTSASDINLEENFSMEKLSLHPSDSTQSSLNDDSKYSSTDELPNKAISYKSEMLRMFGDLEGKDIKTIKNEEINDLIVKDSGIVERQISPRSDDIPSYNRGSSDGSHKTLQFCEFHQVDEQEFNEIDEQRFANAKYEDGDEKNANNDDSQSIEELKISETNSSVTHSNVVSLKKKFGIHGNLYLPRKEQSNDNNETMNKYINETTNIHEKSSKNRSIDIPSNFWEENKQNLRLPKLFPDRSAIDNLYDILMKTEGDNSRDEILQITIIDGNPCSINLENIDKPSESNSNRDGNLQIDEQLLESYIDFAGNTSSFNCSQAIEAIKGDSHVLKKMMFSRMFMDLKRLVGERERTIMWIENAQNEDSLKFLSFKSLHYQQTFIWKLKEAKSRLDKKINDIWTRLIDEKNNSLSPAQNEWIHSVSSSNFLRARVRSEPIITNTKVCIFGLFISSFFSLFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC75</accession>
    <name>A0A0N4UC75_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS478</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC75"/>
    <dbReference type="STRING" id="318479.A0A0N4UC75"/>
    <dbReference type="WBParaSite" id="DME_0000485701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000485701-mRNA-1"/>
        <property type="gene ID" value="DME_0000485701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000485701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18502" checksum="86D84F3F08B8D65B" modified="2015-12-09" version="1">MSQEDDLCIFCSIFNVNTIFGFIYATILIIGVCGNLFVATMILIDRKMFGSSINLFILSLSFADMGNLLACCPDIAMFLNGAGWLLPDIFCPTLRFLEEYFLYASVLMQIGQMLDLYILNSSNNAKSDWDYCIRYKNKAFLSLTAYLKMEDTELSLIMGGTVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC85</accession>
    <name>A0A0N4UC85_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS489</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC85"/>
    <dbReference type="STRING" id="318479.A0A0N4UC85"/>
    <dbReference type="WBParaSite" id="DME_0000486801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000486801-mRNA-1"/>
        <property type="gene ID" value="DME_0000486801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912424at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF4">
        <property type="entry name" value="CHITIN BINDING DOMAIN (CHTBD2) CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000486801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="566" mass="58277" checksum="AA41549E251A6CEA" modified="2015-12-09" version="1">MCPGSTGQPVAACSPAMACPPGTHGSQGTQPCGFLEQCPQNMGCYQGVCCPLSCPTGHSPTGFCGQSKSSCPQASSCVSGCCCARQEQAIVPVCPSGHPSAQRCITNQGCPPGMECSNGGCCPIPFCPLGAQAQGRCLTGTSCPGNTVCMEGLCCPLPRCGMGLLAVRICLTSSECGNGFECVSGGCCPLPSCGNGVMPSQRCQAGGCCCPSGQHCNNEVCCPLPICPGGVISAKVCATMIHCGRGNECVNGGCCPLPLCPSGAQPSQRCSSSNACPPNQACENGMCCPLSICINGQIAVQPCGIGNMCPVGYVCEGRGCCLEPMPLCPNGGRATQKCDRGRDCPPGYGCTSLGGCCMLSLTSICPAQQSAICQCSPTNACPPQSACSMGSCCTSGVSAYDLIPGSSCKSSHRCNGFNSNLATCLQNICICINGAISVGVTCQKLSPALLQQAKSGCDQYGSPCKYIFSAARRKPIFAPVDNVTDEPLWYNVVSQRKCVIPIALVSLMKDAKLWPGEYGCLSDIECSSRCENTYCEHATDKSVAQCQCKNGFILYGRCCKNFSMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCG9</accession>
    <name>A0A0N4UCG9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ZnMc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS8763</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCG9"/>
    <dbReference type="STRING" id="318479.A0A0N4UCG9"/>
    <dbReference type="WBParaSite" id="DME_0000496401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000496401-mRNA-1"/>
        <property type="gene ID" value="DME_0000496401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF309">
        <property type="entry name" value="PEPTIDASE METALLOPEPTIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="347"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="12">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000496401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="47660" checksum="AB1B8206B252A7AB" modified="2016-06-08" version="2">MLERRCGNRDIKIRSEFQLKNNRHRRRRYVIEGSFWKHRNITYRIVNYSKSMSRGDIRKVWEASELLKFSYKTRGFVDLKIAFVKREHGDGQPFDGKGQVLAHAFFPRFGGDIHFDDDEFWNHEVDLYAVAVHEIGHSLGLMHSFNRNAIMVPFYRTYSEEPLRLHRDDLNALIHLYGTTKSKTTLEKFPFHSDNNYNVDLCKDSTINAITVTGNGSAYVFKDDYYWKLNDNSIDEGYPRKISDDWEGLSGPIDAILTDLDGDSYFFKKDKYWLFNRNGKLYAKYPRLIVIGLTDTPSDIDAALLSPHDYKPYFFKSNIYWKYSRWGMPNYYPKPIKNLFQNLHMVPQKIDAAVNWSNGRSYIFAGRYFYRLDDWRSMRVSYGYPRDTATWWFGCKGGNRTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD65</accession>
    <name>A0A0N4UD65_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock 70 kDa protein 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Stress-70 protein chaperone microsome-associated 60 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9052</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has peptide-independent ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds UBQLN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Microsome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD65"/>
    <dbReference type="STRING" id="318479.A0A0N4UD65"/>
    <dbReference type="WBParaSite" id="DME_0000525301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000525301-mRNA-1"/>
        <property type="gene ID" value="DME_0000525301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10237">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000030">
        <property type="entry name" value="Heat shock protein HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042048">
        <property type="entry name" value="HSPA13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000525301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51677" checksum="112C44EA08DFF443" modified="2015-12-09" version="1">CYLFNQHSTILTKIYFSNFDINVIFLGSALLAVLLAGYLAQKYGLPPPLPKIVAVDLGTTFSSIGAYQAITGRTDIIPDETGRKSIPSVVAFLPNGTILVGSRAVEQQEHNPFRTIYDAKRFIGKVYNKDDLEFQDDRKRYPFNIKLDNEGRVFFEIPLDSGIKYITPEDVGSIIISYLRRNAEQHFGIKIKEIVISVPAEFDQSQRNATARVAELAGMELRRLISEPTAAALAYGLDKKKGVEYIVVIDLGGGTLDVSVLWLQGGIFITLAMAGNNRLGGQDFNDRIQKHLMKVISENAGSSFNDKEDLQQLRLAIETAKIQLTSFPQCTIDLHLRSVGRFLYKLTREEFESLNEDLFESIIEPIEAALKDAEIGSSDIDEIVLVGGSTRIPRVRRVVGTYFNKAPNHGVDPELAVATGGVITAGVIGGGWPLQACLLLFIVYCVTSIELPPQRRKKHIYSSHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDJ3</accession>
    <name>A0A0N4UDJ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9207</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDJ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDJ3"/>
    <dbReference type="ESTHER" id="drame-a0a0n4udj3">
        <property type="family name" value="Gliotactin"/>
    </dbReference>
    <dbReference type="WBParaSite" id="DME_0000540801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000540801-mRNA-1"/>
        <property type="gene ID" value="DME_0000540801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229860" evidence="4">
        <location>
            <begin position="25"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="103"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000540801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="767" mass="87993" checksum="E9232EEF798C5FD7" modified="2016-06-08" version="3">MLNGDGLVQLVLFVLLCEAWLSDAEFQLTRPFDLWNPFGTSTQSTKKVFTDDVLVRLAIGDVVGKKIIIKDVPWTCDHDPFEQIPIDRDHFEPNPVPPTNNVTIFTFLGIPYAEPPVSQRRFKPPQLLTELPGDRPFFAFLYPPSCAQNVEKRPSLFINDPYPFRVDEDCLYLNIFTPKVSFTILRLDTNSPSINKSKMSMRVSFFCEFFVFLSLILGIFNACDFFLWSKLKSLQLKVSSIMKYPVIVFFHGGNFQTGSANEWPGHVLSSRGIVVVTVNYRLGPFGFMSLGDWETGNYGLQDQRVALKFVQNHISSFGGDPFAVTIVGHDAGAVSVGLHMLSPLSKSLFRSASGMSGAEVSYHSTIGKPALAFNNTVKLGRYLGCSQVIAQQIWDCILTRSTNDIIEAVETIPIEYNRYLFMPTVDGKEVLANPLWLLNSVPSGLINYPSPVPYLTGLNRFDGSEVILEDRKLGEFNDFLRVDQEFMNDFVLEYVFRHNYTMNREATVQAIKDHYTYFPDPSDDNAVRQKFIELATDAYYTAPISLSAHLHSAAGSRVFMYVNNYEFANDGNSFLPKWMSVCHDCDLYLLFGFPFMPKDLLPFHFSEVKWSVQDRNASQLFMSIYRQFVRNVNPNLPFDSSWAPLEPRRHWYMDFNYSYRSDMNTPGILRRDYRWERVSFWNIYLPSLVQFMTTTFSPFEVKLRREVVAYQIGIGIIVCILMVVAVLMCIFGYLLFERSPNRLTNVEQKLLIKKMREPHKNTLIEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDJ4</accession>
    <name>A0A0N4UDJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA replication ATP-dependent helicase/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9208</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDJ4"/>
    <dbReference type="WBParaSite" id="DME_0000540901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000540901-mRNA-1"/>
        <property type="gene ID" value="DME_0000540901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5828827at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000540901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="54916" checksum="963B15A059A18FB9" modified="2015-12-09" version="1">MANVSSFDTNDNNSEIIYGSGIVRKLKEKFSQLSTNQITLNYQSSLKVEKYPPSNKRNIFSKYHGQKVWPNNISRNNETFIRGNNKEKKSRNGRSRSAEPEINRNKIEPEFMEIYRKFIERSQSAFQNTIADEKGILTTICTKKNNLLKKSPTLELSESDNSSASFNVESACATHQPYSDVQHIELNDESRINNQFEENISFDLIQNEKSSNNQSELLISSNKEFAIMERVLSNIQSEKMESSTNNVEMSSQKSHQYISNFSNNSKRKSLTSLFLERKQQFNANEHYINENNNANNRNLRSNDEIILRHSLINLVMEEDIPILMETMSEEVEFESEDFMPTKPNNLNGIIRQTSKNKGNRRECQFGFSSDPPNVFTYIDEITAINENQWKPGEEISFDDYRKLCEEKREKRKGENFEIYKWRTMPYKFSDSELFCNASMKQLSANDLSKGVTSLICYIPSYDMAFNDIITVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDJ8</accession>
    <name>A0A0N4UDJ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Glyco_transf_24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS9212</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDJ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDJ8"/>
    <dbReference type="WBParaSite" id="DME_0000541301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000541301-mRNA-1"/>
        <property type="gene ID" value="DME_0000541301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="42"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="288"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="435"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="16">
        <location>
            <begin position="716"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="17">
        <location>
            <begin position="1216"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000541301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1505" mass="172012" checksum="06F0DCE51C095BB0" modified="2016-06-08" version="2">MKILLHSKIFLYSLLLFIVIIIINGEINKKTVTTSLHAKWSQTSFLAETSEFIAKDDNSLFWSYIDIINSEINTEQWPSCSYSYICYDLQTLIKCNMTLQLGSQILFFQKVLGSEEEAKNCIAFAVVHDLITCDPQKIEELVRNVSTNSVIPRLYSIDHVFPNSKEKNVVVIVYGELGTKSWQEMHKAAKILARSGQIQYVFRHWSRDVRDDKILLSGYDVELAIKNMEYKAVDDSEVEKATAADDEIEEDIDDYEDINGFNFNILRKLHPNQKEALNQFRLHLLERDELTPLKVWQVQDLSYQASQRIISADLNKTLALMVEISQNFPLLARSISRVSVRPEFRLAVVTNQAMYSSENEIMEGECAMFINGIPVDLEYFDIYNFLDVLKVEEKLADGFFRLGLQVMILILRNYKSFVAEEDKPAYALDFRSASPEYLNNLDTDKHYRQWGNSVKLMLQPYFPGMIRPIARNFFTLIFIIDLSQTQNLHFLNMAYNFYKHEIPIRLGFIFVVNTDKSISGFDDPSVAMLNLYNFIKTDGGILKAITSLIKILTKSEENSEKKNLLTSNDVLSFFQERYPDQDLNDIFGLDTDYDSGRSSGKKFLLDSGLKDVPKVLLNGIVLDDSGIGPLRLEETVTNEIMKETSRIQRAIAKGKLTDDDNVMNWILNQPHIMPRINKRILDAPLHMPRYLTIPDHGPCPSKIISDYHHLPLAKHIKCMMGRIRYLSRSDEDVVHPLTLWIVADLEDTDGRRLVYNAMKHVRSCHVTRIAIFSNPKEIESATHSGSISMLVNAAMRVLPPNQKKLFVTKIVKEEFASKLIDGAMSLEDIAVNQLLSDELVAGAKFVQKVFGLKSGDRGIITNGLLIGPLDDNEDFELNDFDLLEKFIVNRGAQLEKTEFADDKSKLSDTITGIMALTGANSMKKKRQILLNASDSNGVIKFPAQHDTMGILDIVCFIDPLSKAAQRLSSLIFVLQEVVNADLTLILNPKAKLSELPLKRFYRVVLEPTVVFDSSGGISSSAYQARFSSLPNKQLLTLSLIPPDSWIVEVVSAMYDLDNIRMEQVTKHVIAEFELEHILLEGHCFDEISGAAPRGLQFTLGTSSNPTLYDTIVMANLGYFQLKGNPGVWSLRLRAGKSKDIYDIASHYNTESEDENGLNIVIDSFSGRTVRVRVTKKEDKKDENLLMEGKAGDEESEPSIWNTISSSITGGERYDAINIFSLASGHLYERFMRIMILSVMKNTKYPVKFWLLKNYLSPNFKEVLPIMAKIYGFDYELVEYKWPKWLHRQTEKHRIMWGFKILFLDVLFPLDLKKIIFVDADQVVRTDLMDLMEYDLGGAPYGFTPFCDSRTTMDGFRFWKKGYWANHLAGRKYHISALFVIDLIKFRQIAAGDRLRGQYQGLSSDPNSLANLDQDLPNNMIHQVRIKSLPQEWLWCETWCDDASKSKAKTIDLCNNPQTKEPKLDSAMRIIPEWKDYDTEIKNLLLRIKTEDFEPQISDLDTHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDW6</accession>
    <name>A0A0N4UDW6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3715 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9283</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDW6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDW6"/>
    <dbReference type="WBParaSite" id="DME_0000554201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000554201-mRNA-1"/>
        <property type="gene ID" value="DME_0000554201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5960959at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF11">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000554201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="984" mass="108887" checksum="C6E7056F6CC254AF" modified="2015-12-09" version="1">MDTLIVDVPIESEKFRNLYSPIFSSKISNNFLNQNNMKIIACKAINNIRLENKFKKCQSKLESNGEPSDVSFAFFLTDSIREAELYAEHGLNTPNNFIGDLGDATKGVYLNENPDLVTPGQFPHDAPVIILACKILKGRSKVVQLSSFRTEPSAGCHSHIALPPHDHKLNRHDSYRYNQIYLFNRLKNGFSRVPSNVLPFAIYEIIFSKKNLNQPPRTNIVWEGDLKIGECVCEKVQLASHTACLKPPFLEKVFEISDLVSWENCIGFDPILKLLKPTLVGEISVKKEVAIPDCNLFANYYFLQMKAEGNIRFMSLLKSMRVKHAVGISILPGGGIIFLIPNGQFSSLLTLPIKADTFHCIYFSTISLVFGAFEISTPAEDNEFHRLPVLEEKITGLSDQLQNFARRMAKFLHSEEPTICKIWEQSFESGPNDSVDVEVPCIKTKVEDKSEVQLRPGDSVASTNNVSANSLKVTHNIDMNINNSLPKLYSEIRDPRIRPRAVLNANQNAPSVSTPDILNNIQSDLKNSNPLAETSEAIKEDLRSTDVPGEKSVEERCYSPSNPTNETDDSSRCYSPSDILTRSPSPSPIISHIVCGIETQGGSKTDMVDEDSDSEGGLIISPASPPPQDKNVYIAAPAPKIISADDLRNTQENSFNSSNYTYKPLEIPRFPRFSNTEAAKNFQLSEEAVRKLSEIKALAGLSFLKSPTKETEIGQSLSHDEAVKGKDEKIDEVPCIQSPDPSFSSTAPESNAIQESSFHDRREDSKACGSVLSGNLSEADISHPCSSNTSRRSRWDIRPPLISNNGDIDMRNHVFRAPGIEYCPRVESRAAPLIPSTFASAITVRPFTSSNGDTDHRIYYATVPAAAGRSDLIRSGSRQNAPNTLPFRLHSPLFSSRPNNAASSFSIRNPRSIRHTIPARSDFPGPSNAVLNIPHGYCGTSQHLGLQKVDFVDIPPPLFPSKPTNLSMQGVVIPDENLFKDALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE10</accession>
    <name>A0A0N4UE10_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL51</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L51, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS635</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL51 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE10"/>
    <dbReference type="STRING" id="318479.A0A0N4UE10"/>
    <dbReference type="WBParaSite" id="DME_0000559001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000559001-mRNA-1"/>
        <property type="gene ID" value="DME_0000559001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059330at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019373">
        <property type="entry name" value="Ribosomal_mL51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10244">
        <property type="entry name" value="MRP-L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000559001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23796" checksum="B5C6AD64C7E20337" modified="2015-12-09" version="1">MSAKPHSLVVPAVSTVQFIRTLRNRSGVPRVVADPDSKMYFTGDIGYFYRYHRKGVDTLPRIPNCRVPITRPDYKVRNAWCDDQARFGENDYIDLLGDGQLHPAQLQYHTPTWLRGFPGQHRANELIKLIHYRNLYKNKLEKNSPRRWLELNKRLKYLLKRHNYEKQDELKGERDLGLWEEKPDYFYKDKSRRSYEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF06</accession>
    <name>A0A0N4UF06_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent RNA helicase DHX34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS930</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF06"/>
    <dbReference type="STRING" id="318479.A0A0N4UF06"/>
    <dbReference type="WBParaSite" id="DME_0000599101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000599101-mRNA-1"/>
        <property type="gene ID" value="DME_0000599101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3363059at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004714">
        <property type="entry name" value="DEAD/DEAH box helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001922">
        <property type="entry name" value="DEAH (Asp-Glu-Ala-His) box polypeptide 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056382">
        <property type="entry name" value="DHX34_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24485">
        <property type="entry name" value="zf-C2H2_DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="296"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000599101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="973" mass="111667" checksum="C2F1795D225B5D0C" modified="2015-12-09" version="1">MEMADFQRIPLLPVNVIQEFTYALSLFVLFENKVKMNKLRNLRKSQKNLPIAAKRTELLQTLLNTQTLFIAGDTGCGKSTQFPFPDQYISDLYQMCRYRKLKLLKFLYYFTTSLYSVNEVPQYLLEADYDRIACTQPRRIAATALARRVAYETLDEYGSKIAYQIRFEKTRTLRTQLLFLTEGLLLRQMQMDQNLSQYNIVILDEVHERNLSGDFLMGLLRDLVRRRSDLKLILMSATINIELFQNYFKDAPLLKISGRLFPIELHYIPIKEYDNYANQRKKPKIDAAPFVNILQMIDGKFDKSERGDALIFLNGIAEITAVADALKIYAESTKRWIILILHSALSTEEQDKVFDVAPVGIRKCIISTNIAETSVTIDQIRFVIDSGKVNLMKFDPKTGMHSLHEYWTSQASADQRKGRAGRTGPGICYRLYSSEQFAKMDPFTISEIHRVSLESLAMQIVNMNIGIIPRNFPFIELPNMNALDEAVDSLIKQGILEPDNESALTSLGKIIASIPVDIPIAKMLIYGCIFSQIETALTIAATLSINSPFTVRSARDPEILKKRDNLMSHFGDLFTFLNVFREFVKLHNKRADIRQWGREKGIDIQRIYEISQLRRQFKELLEDGGFIDKSKGENSKERRISAGDRKRLSELKKDARYEVKKRKTLKAGAHFDTIADDEGGPSFTDNIQAVEFYIKNRESGIRDILESHHLTTKSIVMISMTVVAGVYPQYAILDQYNHYKVGNELFAHTRKKPFAGLHPNGCLALFPDALSYDQNDQNLSRYHQLIVFASLIETTKPFLCNTISVPALVLLLVAKSVCCSDDDYSIVCDDFVHFKFSRASDFFTIIENTSSIRCQIASSIRNRLNGDCSESKSLIKNITSFLKYDFEYRMTRRACPEDVVSIGFILPTGEKLLEDEENDVASYLRCNKNDVEIHELEKSEGITNKVEYFCEICRKNLFFDSNFDILRHKRIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFS7</accession>
    <name>A0A0N4UFS7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1203</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFS7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFS7"/>
    <dbReference type="WBParaSite" id="DME_0000630601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000630601-mRNA-1"/>
        <property type="gene ID" value="DME_0000630601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000630601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12435" checksum="63169D690E9F0484" modified="2015-12-09" version="1">MALAIDSISLAELLSSNEPFKKVLVVDCRSFFNYNKSHIRRAINAFYSKMMRRRLFDSKVSRFFGESYSSNFLVIDLLAPRVQVESLPLNGDLDHDPLVSYDPKTVGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFZ1</accession>
    <name>A0A0N4UFZ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9494</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFZ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFZ1"/>
    <dbReference type="WBParaSite" id="DME_0000638301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000638301-mRNA-1"/>
        <property type="gene ID" value="DME_0000638301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000008">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF29">
        <property type="entry name" value="AMMONIUM TRANSPORTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="34"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000638301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57631" checksum="75324C81D7A8BC4F" modified="2015-12-09" version="1">MNSSRIKLETDHYTDFISISSQHEKDKLVQDDAVWIITSSFIIFTMHSGFGLLESGSVSTKDEVNIMVKNVVDVVFGGLSYWAIGYGLSFGDASGFENSFIGWGKFFYDPTRDDNKALKEGWAYASFLFQLSFATTASTIVSGAVAERAKLKSYILLGCFVILIQALPAHWIWDRNGFFFALGVVDFAGCSAVHMVGGMIGLMATIYLKPRRNRFSKDSVHQMSSPTNALLGTFMLWWGWFGINSGSAWGITNGRWRLGARAAVATIMSSIGGGATSIVVSFIKTKKLQINFLIYGLLSSIVAITAICAVARPWHALVIGSVSSAISISILPILEKLKIDDPVGIVPIHLTSSLWGMFAVGLFAEDDRFLSVTYGQYGLFYSGNLNLLGKQMLCSLTIIVYSAVIGLAVLMGLGKSPLGLRVTDYEEQIGADAVEHGLAGQNVARYHIEKPISNKTFATVTKAITKWKLLTRRSRMLRQQRLQQMMEKSETNLNELRKRSAFALDAEALEPNGSNNYCTRNIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG70</accession>
    <name>A0A0N4UG70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved oligomeric Golgi complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9583</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG70"/>
    <dbReference type="STRING" id="318479.A0A0N4UG70"/>
    <dbReference type="WBParaSite" id="DME_0000647201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000647201-mRNA-1"/>
        <property type="gene ID" value="DME_0000647201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000647201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20784" checksum="6B94E592358B7CFE" modified="2015-12-09" version="1">EDEWLKSLQENLKKSETLRKEITVLLKSFEDRLEWLDQNVVPLYKTTAILQRKQTNIKKILKTVDAMQQFYGRAAELESSIREGNASVEREEYIERMEQLAEAISFFSAHPAYKNQLDNMKLTFESGCCVLEKEFRNVLSADSVVADAKTVVNCLDQDYGSFHFPLPQFILYYICYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG87</accession>
    <name>A0A0N4UG87_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9603</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG87"/>
    <dbReference type="WBParaSite" id="DME_0000649201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000649201-mRNA-1"/>
        <property type="gene ID" value="DME_0000649201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830488at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000649201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21669" checksum="6AA60E0FD43E1368" modified="2015-12-09" version="1">MQKFVGCICISYQHLKIIKLDFHKLSALKFLKFLYFQLSSLLIVVFLTDGHLQWFFYSVALFCCIALLIISFLTIIELFFNFFAVFLCVLLTGIFIYDVISMLSGSFNHHKYMPPINIGRDGWRNRMIICSVIVFLLHIEKKNLLSLFLIYYYNFLLVLPLFYFYSIKLITAPSYPKSCASELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH14</accession>
    <name>A0A0N4UH14_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extensin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1422</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH14"/>
    <dbReference type="STRING" id="318479.A0A0N4UH14"/>
    <dbReference type="WBParaSite" id="DME_0000680801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000680801-mRNA-1"/>
        <property type="gene ID" value="DME_0000680801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039205" evidence="2">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000680801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27444" checksum="0B02794BB8A70341" modified="2015-12-09" version="1">MYLLLVLFISLLQVCFTQYGEPSIEVQPPAPPPSPDYVQLHQSSAVVQQRPFPPVAPKITASLPKPAPSIISQQKLTPTAAKVVQSPPKSTKRPVAPPPSPQGVDAILSPVIPLQKTTILRTKPAILKESLKPSEAESETIPSLKMLEKPAVSTVPVEPISIPRLRPISPTFEADQPEDKGVKIEQLISATESPAEEEFRYHDCISDTLFVVDSTSSVQKFFEDHRQYVLNTVDMLESISENGTRVAGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH26</accession>
    <name>A0A0N4UH26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1438</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH26"/>
    <dbReference type="STRING" id="318479.A0A0N4UH26"/>
    <dbReference type="WBParaSite" id="DME_0000682401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000682401-mRNA-1"/>
        <property type="gene ID" value="DME_0000682401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000682401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39998" checksum="38EFDE73F500DDFA" modified="2015-12-09" version="1">MNYTIGNTKSANKEPEAISLTLEIELDDHRIIQHSALNAYVSLPLEEFYDRPTDIYEIKPVIASGYRICNLCAVAVHQMEMYLNVPSYGSLLNWENLAAKLGLSILQILSLRKCVSPMLKLLELHSNLPLNIIIDAICELNRVDLLISLIPYLPKNNLTSDQISLDSGICNNSNNNNSFLQNERFHSDHLFTSRRSKQLVDILVKSILVMHHENELNINLKKNFNWFMKNLKKQASGKGTFIFDVNDYLCGEGSMVDLIEIFKQATHIISVLSEDYSKILNSDGDQQNAVKKYINNLMNTEYIQDGSINKRFRAVMLQGTDRAVLPIGWSRNTVIYEFPANHAQLFKKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH50</accession>
    <name>A0A0N4UH50_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1467</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH50"/>
    <dbReference type="STRING" id="318479.A0A0N4UH50"/>
    <dbReference type="WBParaSite" id="DME_0000685301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000685301-mRNA-1"/>
        <property type="gene ID" value="DME_0000685301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF252">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000685301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25291" checksum="5AED080555710A41" modified="2015-12-09" version="1">MYIIFVKIFQLVGGIALTVGVWLRTDSRFRDFLSERYRNVVEEAFWQAPTLYIFSYVLIILGGSITVISMLGCCGLVTQSTLLLVIYSIIIAAVMIATLFAGIYLLFKKDGIDVEISDALNYMVQHYYQGPGIIQESLDRLQQTFRCCGNAGCGDFEVFRQDPPRSCDIRCDGCHYRIMTALRIGFSVAAVIFFVVIIAQSRSYYLWLQKKIIHGKKWLVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH98</accession>
    <name>A0A0N4UH98_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VPS37 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1523</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH98"/>
    <dbReference type="STRING" id="318479.A0A0N4UH98"/>
    <dbReference type="WBParaSite" id="DME_0000690901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000690901-mRNA-1"/>
        <property type="gene ID" value="DME_0000690901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984298at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027487">
        <property type="entry name" value="Ribosomal_mL48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000690901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46944" checksum="03ECF6CA66677DA4" modified="2015-12-09" version="1">MGDSSTSYESLLDLCVSSAMGPVRNFNCEQLNILLSDDSKIDSIIDNIPHVRNLPTEREMGLVQNKSLAEWNLTQEPLLEELKKNLLETYEEAFFTVCIAESLTEKRSLNTSSALLQTAVQAAEDESEAIADRFLNKEIEVEQFLKEFLEKKTLAHMRKVKSDKLLATLRQQDYPSLPNQATPYPVHENNFYPTPPATRHSFWLIYAVCRRLWSTCKMVIQLMLAGSSLKNSVQCRWFASLREMALAKGPRHIYEPLFDEKKRCPDYGMVHIRLQGYDYVPLEKYQSYVHKIAKRFEFNVKESYSVAATTERVVTFRPHTTIVESEVVLSIYERVLNIIEAPSVYLPLFISLIRAHIPIGIKITVKKYEKDDERRRYIPDVMLKEKQNELKDLDNPVVRRNLGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHC7</accession>
    <name>A0A0N4UHC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1529</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHC7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHC7"/>
    <dbReference type="WBParaSite" id="DME_0000695001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000695001-mRNA-1"/>
        <property type="gene ID" value="DME_0000695001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF5">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="360"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000695001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60531" checksum="F5535792DC764724" modified="2015-12-09" version="1">WQNIILYFRNFYSSPLEAINEFGSFYHLWTGFVSIACLYNYLTIVLMVFDDVYNYYYNYWIYANILLDFVNILDIVVQSNFLLDILAILPLDFLLIVRPDFVWTRTNRLIKIYRIWDFVRLTETRTSFPQIFRVFKLTIICYIIFHLNGCLFFFISKQYNFETAFIEDWIFSYDKISDPVVPYSDFARNSPNITFFHTGQINQSYVEDLMHYWQNKTLSIKFGNFIKQYALSFYWSALTLVTLGEQPPPNKTSQNAFEIIVTLLGIIIFAVIVGEIGSVVINMNAVRADFEEKLDGCKQYMIFRDVPSQLQERINGWFEYVWEHGQAIVDEEAIAEFLPSRLYASLAVSVHMATLRKVKLFEDCEAKLLFELILMLKLQVFSPFDYVCKKGDIGKEMYIVKEGELEVVSEDGDIVFATLRAGTVFGELSILDIPGNKNGNKRSANVRSVGYSDLYVLTKSDLWEILAEYPHAKSLLIAKGISKNFKKFPTGENNFHLVNFVIPPKISLLLIRNIGHSLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHE3</accession>
    <name>A0A0N4UHE3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NFACT-R_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1548</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHE3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHE3"/>
    <dbReference type="WBParaSite" id="DME_0000696901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000696901-mRNA-1"/>
        <property type="gene ID" value="DME_0000696901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="408"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="701"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000696901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="793" mass="91897" checksum="6CB260C086A93AE5" modified="2015-12-09" version="1">MKNRFSTLDLFAIIHDLKKLEGIRVHNIYDIDNKTYLIRLQNKKYFLLIESGIRIHKTDFDWRKSMFPSSFTMKLRKHIKQKRLTGLNQIGIDRIIDLKFGDQQQSSHIIVELYDKGNIILTDYDYIILNILRPREDKNSDVRFFVDEVFRYPICEARQKVSCPTKQDINSIFLNPNLPSIFSFSIVSIFNFQEFHPFKFTQYCNMEISEFETFSDCVDRFFSKLQEQKADEKALNAEREAMKKLENVTKDQQERIRCLALAQSDEEQMAHLIELNVELVDKALYVIRSAIANKVSWEAIDEMRLRAAKMGDEVASVIVELKLDCNQIFLLLNDPENEEIGPKKVPIDLALSAYQNSQKLYSLKKLAAEKQRKTELAAQRTSFLKHNLFQVRLKAVASKMRRTMWFEKFYWFISSENYLVICGRDAQQNEYLRKGDVYVHADVRGGPTVVIRNETMSEIPPKTLNEAGVMAICYSSAWASNLSANAWWVYHHQVSRTAPTGEYLTPGSFMIRGKKNFLPSCQLQMGFGLMFKLADESISAHANERSACRAANDIIEEEVFLKNGDEVPLDEIVGTENGEEYTIMQIGPTVSRKDFVKTPEIRDEVIDEYKSKNINNQSDSQSRPLTIRQRHKAAKIKKKYKNQDDEERELRMMILGTTKGQEKSKHLMRIFLFLRALTITGWTRCQEANEDFDEINEQSSNEENLINSLTWAPRLEDILLFAIPVVAPYQMMHNFKYKVKLTPGTGKRGKCAKSAMQLFEQELGLIKLLASDDQISRNIPGKVRVSAPLLYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI89</accession>
    <name>A0A0N4UI89_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9946</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI89"/>
    <dbReference type="WBParaSite" id="DME_0000731001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000731001-mRNA-1"/>
        <property type="gene ID" value="DME_0000731001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844878at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000731001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17658" checksum="1B57EEC0DF0D5F2A" modified="2015-12-09" version="1">MIVVGVEQFLPLHHISISFYCAFAIAVIVANDTFCGELIVYKQKWFNASNARTIYSKKANGLKHCLEICCGISSKLFFNFCLAIVFLESWKLTATFKSACSSAKQKIVQVFSSLADFCLSPIHPQITEIYSTQQLCTNNLLSLHNSLNHYRFSNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIJ1</accession>
    <name>A0A0N4UIJ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10062</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan nuclear receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UIJ1"/>
    <dbReference type="WBParaSite" id="DME_0000742401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000742401-mRNA-1"/>
        <property type="gene ID" value="DME_0000742401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854198at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="128"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000742401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60787" checksum="306445716415AE58" modified="2015-12-09" version="1">MFAKGKSGREFYEICRVCGDGHARMHYGVLTCFGCKGFFRRTLKRTSEYSCRHQGNCIVDKHERNSCRFCRFKRCLEVGMDPKAVRPDRDATGRHYQTKVRRLKFTSGDESSDEAIITEDWSRKLSVEMRTILMQLMNIEIMVNRGDTNQKAVDLYPLPFNSIQQILNNPSLLNGKRTEVVRYEPYRQVENNELVAVAHRRLIVTIDWVNHLFDMMDLTGFEDKIALIRNGFAPLMIFSFAAATAKTTKEKDIICLCSSGYVPRNVHSIFNKPYHLANRIIERTIDELTQPFRNLNFTEEEIVLMKAIIILNPHVKGLSSDATDQVADLRDRIQEVLYHVVRETHPKEVASSRFGNLLLFLPTIMILGNIMCENIQLMQSFERKDADQMLLDLFETEAVPTHEIRKPIDPCCSSESIEFRTSMAYNYGYIEPSSSSSSISSIEFLPQLSSFDQRRYMDSTNSLHDMLSECITESDPDYNTTLTPDTFNEMQQAHTGINVIDIDYHGTPPNSPEFSLVQFSRPEFYIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ17</accession>
    <name>A0A0N4UJ17_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000036">
        <property type="protein sequence ID" value="VDN51922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ17"/>
    <dbReference type="WBParaSite" id="DME_0000762801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000762801-mRNA-1"/>
        <property type="gene ID" value="DME_0000762801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000762801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58494" checksum="F2135A42EF4B4372" modified="2015-12-09" version="1">MLLSLGIVLFWKKESGNLTVDDISQLEIHEELATVGNDSAFMRKQITTGNGSENKTEKNWPLKNIIKLSMSNEEAPNSNTRKSDTYMEGFGQLVKIYGEVNPEKAVKDHAMITVPHLETMSKIKTNFIAETSINTERSHTRSHKKPEAKTRLRTEEEYEDLITSSASIINQSQLEYPEKIMHNITLHNILDDKGLNEISLIDTALESSVLLATIQNARKEANPMSTIFPQNIPSYPEVSREENQTEINLMNTEEELPKEHNIDELGPEKLLKPEIVNGSVVPKANENISAALIFPEAINNEEKTFGADLLTQIDGETWTHKPAEGNWTTAPTDGVSSTLIISVKKAISQHATNKKSKSREETINNNQITSNLIEKELNETKSIDFPEIYQNYTEDLRKSKYSNAVVTSTQSKDKIIAKISNWPQTNKLKIKNQESITINIIELPQTNSTGGMQDVKISLQTELVDENVTKSILNLFDIESKAYANDSSLNDTLVSHQQSITEKKETEIIVTEGKFFYESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ87</accession>
    <name>A0A0N4UJ87_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10142</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001203">
        <property type="protein sequence ID" value="VDN60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ87"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ87"/>
    <dbReference type="WBParaSite" id="DME_0000770801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000770801-mRNA-1"/>
        <property type="gene ID" value="DME_0000770801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823734at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000770801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="38225" checksum="A30D554319BB3CF6" modified="2015-12-09" version="1">MNDLTEFAMARSFPIEGSLPDIAQTREENKKLKADLFELKSKYYLLKQELPTIRDLKDVDFSEDYINLRIKLSESEKERLNFKAEISELSGKLSSLTATRKQEKLEWNEEKQKIVAEINQLRERMTDLNQELYLKTRTFLEPDLEKKKPSVDDESHAESCISNISLISESSRQLAEMQSIMLRKLFDQEKAKLEFIKEIDSLKKKLLVLELEMKEKDRQKDEMGKIYEKKIKNEAYKFEEEIKKRDKAINALAKALDKKEKINSALHPFGCENDDIHEKVIDFIKKRPLLKEKFFVDEKFNGNANSMEKVQTDHILLMSSTSDFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJD1</accession>
    <name>A0A0N4UJD1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1956</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000039">
        <property type="protein sequence ID" value="VDN51983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJD1"/>
    <dbReference type="WBParaSite" id="DME_0000775901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000775901-mRNA-1"/>
        <property type="gene ID" value="DME_0000775901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000775901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15193" checksum="AB529EE52759DD64" modified="2015-12-09" version="1">METACYTNMLSKCGEKIVQASIIHTAPGCKSMIDSDNEEDIELQLHRNLSCSSRNSGREEEWQAAGSSSWRNAQLGISINSTTSPMDSKVIFEFRKSTKSVVYDRPMRCIAMSDMLLQRITSSLTKIPQKFSENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI6</accession>
    <name>A0A0N4UJI6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">H15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10195</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJI6"/>
    <dbReference type="WBParaSite" id="DME_0000782501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000782501-mRNA-1"/>
        <property type="gene ID" value="DME_0000782501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000782501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17430" checksum="83D4978CACDEE6F0" modified="2015-12-09" version="1">MSETVAPGEEVRGAGSPKRMKKAGSAKTKSAKVPSSHPPYMNMIKSSISALKETKGSSRAAILKYIIQNYKVGGNLAVVNAHLRIALKRGVATGLLKQVKGTGAAGSFKLSGETKKNKIKTTESKAKPTVKMTLNKPKKTPMKKTMKAKSSTTKVRIPLLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI7</accession>
    <name>A0A0N4UJI7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10196</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJI7"/>
    <dbReference type="WBParaSite" id="DME_0000782601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000782601-mRNA-1"/>
        <property type="gene ID" value="DME_0000782601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161974at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="374"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000782601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="670" mass="76380" checksum="F07E3DC180AD5C41" modified="2015-12-09" version="1">MDFSIGSSLLSTRKQQTENIYANCIFKDQNLQLHKLSDDCIRLTFISYLNKTTNVEERYEAEIRKLNKEMECYRGTILKLTAKHDGYNHLIQIFDNKLKIMAKCVENLQNKSTFKDGAGELLRHPSLESVTSHRSSMSSSSKGSKTDKSSLNGFGKQAKKSWVREKFFFKLLRMSSCSCFFFRLDDIDSVPQLIELKKQLQDKDSTLTDVRLDALDKAREVDVLKETINRLKTENKILKQNYTILERRIRAESRTSSQQSLSILSDEGPVYETPPSERSVSSSDCPSGSINLKVTVSVDFSGFLRPQISSNEISIGSIAMPNSEMSWQELDSRLIRLFNDYISRIDPNAAIDGLILDCLFPRSVIDQLLNALLTCRRLVLFGATGIGKSNLARQLAKYVSLIIGGISNNSIVDIRISDDDHDKNIAQVQRDLESYLRSSKPIVILLDNVQRHRIALLSSSFSSIDVPAKDGPYVICTVNRASQLPEMQMHHNFRMFLLPNNVDAIRGYIGRYLRRRILENEFRNNEHAPPELYRIIDFLPKVLTAINSFIEKANSRDVTIGSRIFLQCPLNIEQSLQWFVKLWNQMIIPYMIKVAKEGVKVLGRCGSFEDPTDTICEYWPWIDGPSAEESLQRLSIKETLYNSSNGTQFNPLEALMRIQSNNSNSQQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKU9</accession>
    <name>A0A0N4UKU9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2390</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKU9"/>
    <dbReference type="STRING" id="318479.A0A0N4UKU9"/>
    <dbReference type="WBParaSite" id="DME_0000838401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000838401-mRNA-1"/>
        <property type="gene ID" value="DME_0000838401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229919" evidence="1">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="307"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000838401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39058" checksum="887C183462BAC3FB" modified="2016-06-08" version="2">MTRIWIISFFLYSILLVVSSHYGGNQYNRGGTSWHSGYGGGHQAGRIAHRGGGYNTGPSCPPPPICPPQRCSPVQCPPPPICPPPPPPVHQPCPPAPPPPPCPSLPPPRPCPRITCPPVLPPAPCPPIQCPPPPPPRPCPPQKCPPLSPPAPCFPRPCPPPPPPPPCPPPQCPPPPPCPTPMCVAPPPPPCPPQRCPPPPPLPPCPKPPPPPPCPVPLPPRCPPPPPPPPCPPADCPPPPPPRPCPPPLCPPPPPPPPCPSFQPPPPRPCPPPPPPPPCPKPPPCKVNFKTNFTFETMFIIVFIIMEMVKDINESKRNVQRIAEKKFRTKFNVICTATSFSYITNTQIYCQFSNLDLTCYAFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL17</accession>
    <name>A0A0N4UL17_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2441</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000061">
        <property type="protein sequence ID" value="VDN52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL17"/>
    <dbReference type="STRING" id="318479.A0A0N4UL17"/>
    <dbReference type="WBParaSite" id="DME_0000846601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000846601-mRNA-1"/>
        <property type="gene ID" value="DME_0000846601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000846601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39513" checksum="1A4827898C46D5BB" modified="2015-12-09" version="1">MSLRDESSTLPGISTRGDVRFDQPWSLPQISVIMDINELSTQSQRYLISNFSYSPGLGNIMFQYAAMKSLSIKYNARIILPESCKLRRAFQLNATYLSDDLTELLIKNLDNRKIDFKECCKYQQELMNGLFSNASQNIELLTGYFQTFRYFHPEEEKRIREEFTFLPEIKKKAERYLQLAKSERLNYKKDKNNNYVFIGVHVRHGIDITMNSRNYLHGHIAANPRYFSHAMDYYRTKYRNLIFMISSDNEYWTKKYIKGREEGEVFILSTGYREVDLAVLSVCEHIIMSTGTFSWWAAYLAGGSAIYYKNWPANGSILEKMVEKKDYFLENWMPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL37</accession>
    <name>A0A0N4UL37_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2465</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="UYYG01000062">
        <property type="protein sequence ID" value="VDN52492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL37"/>
    <dbReference type="STRING" id="318479.A0A0N4UL37"/>
    <dbReference type="WBParaSite" id="DME_0000849001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000849001-mRNA-1"/>
        <property type="gene ID" value="DME_0000849001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051989">
        <property type="entry name" value="FKBP-like_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46046">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46046:SF5">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="142"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000849001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26661" checksum="07CC4779D39E29E3" modified="2015-12-09" version="1">MVSLFLLRWKLSESKCKIKSENGDMLEQFFKLTDKDGNIIGSNFGKDPYIFVLGRGEVIRGMDAAMSNMCVGEQRRVIIPEEYAADGHNIGNIRPGSPLYYFVELKSILRLVPGEKWLEDDGLSIEVTHKIDDDKCKKAEIDDTIHQHYTLHLQDGTFIDSSMQRNEPLIFKLGAPYVIAGMERAVIGMCEGEMRKIVIPPELGYGEEGRKPKIPGNAHLYFEIQLLKVIKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL77</accession>
    <name>A0A0N4UL77_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10402</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL77"/>
    <dbReference type="STRING" id="318479.A0A0N4UL77"/>
    <dbReference type="WBParaSite" id="DME_0000853501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000853501-mRNA-1"/>
        <property type="gene ID" value="DME_0000853501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283463at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000853501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32154" checksum="0D1BB5E3DF0C9767" modified="2015-12-09" version="1">QSARRFYTTVKTIHRPAPAVSASYRAKAFQTSRLLPSQYPKLAEKKKPAGIGNKKPCNCTKSMCLKLYCECFANGEFCKDCNCKSCHNNLEHEVERSKAIKASLERNPNAFKPKIGIASRGRIDSERLHQKGCHCRKSNCLKNYCECYEAKVPCTERCKCVSCRNTENDRAAKFPAKFIPTSDAGPLNESLLDTNRTTNSPFSDEESDQDSDADGRSLPWLYINDEVIEATTLCLVSRAEAAESAKKMTDEEMERALLQEFGRCLGQIISATTTVPTMEAISSWSYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULR2</accession>
    <name>A0A0N4ULR2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCV_T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000071">
        <property type="protein sequence ID" value="VDN52667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULR2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULR2"/>
    <dbReference type="WBParaSite" id="DME_0000874901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000874901-mRNA-1"/>
        <property type="gene ID" value="DME_0000874901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000874901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7644" checksum="51D0422FF2890A06" modified="2015-12-09" version="1">MSLNSRMHPRNPYKDKPPDFEALAGKYEEFRSCCKIGTNGKISVTSSCFIDFAAIDPPDRVGTVDDDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULU6</accession>
    <name>A0A0N4ULU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10476</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULU6"/>
    <dbReference type="WBParaSite" id="DME_0000878801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878801-mRNA-1"/>
        <property type="gene ID" value="DME_0000878801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823275at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27215" checksum="0009EECD5AE78A7F" modified="2015-12-09" version="1">MREERSTVAQTVIFVISIALLISGIGLNIGGLISPSWQVVDIREFRAIHHHGLWQDCSRPNRHSSLYPSLYDDNIPLSCTYKFDYSASEVIGENLRDIDNSAAGESEHHQFFGWQKVVLISAGISLTAGILGACTGLCASCYSACAILYDILVFVAVIFAVAAAGIFFFAAHRVDSRFVQGLVGTYEQEIGFAFYLYGSGTILLLFSFILSIVATYRIYKNSNNRLNIPLRELAPLYNSHVRDTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM74</accession>
    <name>A0A0N4UM74_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NSL complex protein NSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-specific lethal 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10543</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the NSL complex at least composed of KAT8/MOF, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001224">
        <property type="protein sequence ID" value="VDN60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM74"/>
    <dbReference type="STRING" id="318479.A0A0N4UM74"/>
    <dbReference type="WBParaSite" id="DME_0000893501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000893501-mRNA-1"/>
        <property type="gene ID" value="DME_0000893501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876648at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026316">
        <property type="entry name" value="NSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453:SF1">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="592"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="824"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000893501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="935" mass="106452" checksum="A86AF024CF2D6301" modified="2016-06-08" version="2">MRNNKTNSSSTRTKERRAWKCRVVEETATDDMAQCCYISRRTRLHCKNLRPKSALTKEGFCEVHPRFFQQLRQMAKAEQRRNDQGFYSLANGDEDGSIEISDIDETFVTTSDWPFSQQDLYNELHSDDDEDNPLKNAGIVTEEEILVCKLAILKRKRKALRDLRQLLYEKSKRRAIFFKKKIAEEAKKGPIVAYTKNEKRLKMIHKANKKYRRWQQSFISQYMNRRLARRQKIGDDPQKPLDYLKTNKINGEAMSGEGKVEDKCQNPALPLNNFCIKHILRDSKQSLFTKCNECENAALHFEDRICYCFKHSLQRPYQKIESLQSSSSTNSVLLQKDNLINKGSGKIQRDFDNEKRNMKKQPFDKNCSSSAISPKVIAPDFPSMGQKCIQYDGSVIDSRNKIQENVADVKSPPVKVVLIGEDDDLEENRIVPSGRRNNVRTIPVSSPPPAAGIPSRTIPFERQADRYSINSHMNETTTMISDIKQQSMYLQRKEDSEFSCARVRPFVHAPGRSDFRKMERSIPQRFIAVEKRNYNGSDYNQQSPIIQRVRMSGPKKFTSFVFQTVSPQNPSNSTSIDSMRRASISANSNFTQPSTVLRSMPSGTNLRGVQSDRFTDPSTITLGPTIPLREESQTSSYSGNASRISQYVIHGRPQFSSLQFASGRGNSFSSPSWPSRSPAVATNRSNPDSTTFNYLDRSKRTNYEEYQRRQSDRNFPISSARTRLIAINPSSSLHFDQTYQGYISNFNNRPVKEVLRLQHGRFAQQQQNLQPEADVQLQGSLETAAAVASISSALMDKEPQDDEESSTSANQNLTEIENINEKAVEETHSSHMQTTNIQSVKTDERIQNISQNEKNEEERSNAETSSENHSTTNPSFSAQQRNDGSEDGLTMLAMAAESCAANETHEELSNIESTEPSSVRTSYLNMGLEQEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM75</accession>
    <name>A0A0N4UM75_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA (pseudouridine-N1)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS10544</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:13933"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001224">
        <property type="protein sequence ID" value="VDN60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM75"/>
    <dbReference type="STRING" id="318479.A0A0N4UM75"/>
    <dbReference type="WBParaSite" id="DME_0000893601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000893601-mRNA-1"/>
        <property type="gene ID" value="DME_0000893601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000893601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27243" checksum="E849D269A96E9348" modified="2015-12-09" version="1">MIRGSPPSEKRPKIESEESCDSFLSQRRLIIVLEKCSLDVIKRGSNYALMTSSNSNNKNNNDRSKNVHSPRNPADFRPDIVHQCLMMLLDSPLNRAGYLQIYIHTISGVLIEVHPQLRVPRTFDRFSGLMCQLLKTNSIRAADNSVKLLKLIKNPVTDHLPIGCRKILTSFHAENFVKCKKIVSVEEKKPVVIVVGGCATGKVSVDYTTEEIKISNYPLSAALTCAKLTSGFEEIWEVENINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP34</accession>
    <name>A0A0N4UP34_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3324</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000123">
        <property type="protein sequence ID" value="VDN53351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP34"/>
    <dbReference type="STRING" id="318479.A0A0N4UP34"/>
    <dbReference type="WBParaSite" id="DME_0000970201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000970201-mRNA-1"/>
        <property type="gene ID" value="DME_0000970201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720990" evidence="3">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000970201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15668" checksum="403C1CF3A15ECDE3" modified="2015-12-09" version="1">MRLRLIGKIIAFFQVLLRSLSRPFSNVITNLATNHPKLRSLIFIPAGRALIRLTIRLRMQNLGFGKPATVADVTETAAAEIANFILFVSLSLAVFYMSKWVTPETAKKSDFEKAIAVIIFLKNSFIQYVVVYEEYQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP83</accession>
    <name>A0A0N4UP83_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glyco_transf_7N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS3369</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP83"/>
    <dbReference type="STRING" id="318479.A0A0N4UP83"/>
    <dbReference type="WBParaSite" id="DME_0000975301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000975301-mRNA-1"/>
        <property type="gene ID" value="DME_0000975301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000975301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30115" checksum="26A1A027DED72259" modified="2016-06-08" version="2">MEFCDDNSIREEIIGVIMDPPELSEMAKLYPHLKPGGHNVPQTCLPLHKTIIVVPYRDREFQLRIFLYHMHSFLIRQNLEYAIIVVNQTKDELFNRAKLLNVGFVESAKLYDWNCFIFTDVDRMPENTRNIHTCADQPIHLSVDSRLGLLELGLLYYTFMGGAVAFSKTQFQKINGFSNNYWAWGGDDDDLAASCKEILLTLTLDTWRDDGLSTLDYEIDRVEKNQLYVNLVVRLKEKETTAILEKKEQYKMYRKCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPP0</accession>
    <name>A0A0N4UPP0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10807</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001250">
        <property type="protein sequence ID" value="VDN60834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPP0"/>
    <dbReference type="STRING" id="318479.A0A0N4UPP0"/>
    <dbReference type="WBParaSite" id="DME_0000993601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000993601-mRNA-1"/>
        <property type="gene ID" value="DME_0000993601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000993601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60600" checksum="FCAFFC61AE575E47" modified="2015-12-09" version="1">MSGGAGSDCPSSSTNNLCSKIERTSNASDLTRIRHARRPRARYEENERTRLPTSKPFSLASLQIEILSDVVSDQKLISIMEGKVPRAEVSYDDLLRKAVSLVHEKNAKNDEIASLRSRNESLLQLNQTIREKSVRLHAKAEQEEEFISNMLLKRIQKLKNDKEALALKYEQEEEFLTNDLSRKLSQLQNERDELAGQIEAEQSWVVDTLLVKIRKLEAEISANHTALEQLRREKVDLENALEHEQESLFNTLGKRMDQLEAEKRRMQARLEQSSLSEDHSSYSSGNDNSIAHDEYFSDGTERRSTRAETEARKLREECTRQRSVIANLKATIGNLQKQLTDQETKFVGELLSIRGKSAEMRADNRRACSALEADLTRSLESCRALVASETVRNTEEDKHMTALINRMSVPKSITPTPTSAAVSPSMSSNVEIESTGWSEERPISARSDLQVDKMEEGSDAADTDMDAQMDSSYFSENLQIGSERSVEGSIKNSGAYQSPFSSLSNEDSNESTEYAMPGAGQFARPALPHTRSPISRKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ03</accession>
    <name>A0A0N4UQ03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ING domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3593</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000154">
        <property type="protein sequence ID" value="VDN53620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ03"/>
    <dbReference type="WBParaSite" id="DME_0001006601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001006601-mRNA-1"/>
        <property type="gene ID" value="DME_0001006601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001006601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19125" checksum="4806058FC46483A5" modified="2015-12-09" version="1">MNSAIMRIITELEKSCKEHFLESDSVFKRFESMENYAELIQSIREKGIDNVEYDESQDALCQKEQRLQSLQAEIAEERENFIQLLKVYDRVDVIDAPDLQKIGILEDLQKDVKMLTSKLYDVRKIKQKILLSQKNLAPNQFDNYAPDHSGVQSDELLTGGLQSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR61</accession>
    <name>A0A0N4UR61_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3967</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000233">
        <property type="protein sequence ID" value="VDN53994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR61"/>
    <dbReference type="STRING" id="318479.A0A0N4UR61"/>
    <dbReference type="WBParaSite" id="DME_0001053301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001053301-mRNA-1"/>
        <property type="gene ID" value="DME_0001053301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="27"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001053301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53100" checksum="1343D1E029DB5F96" modified="2015-12-09" version="1">MTKEIIGSNKITDLEIEIKTCKKSKGLGWFTTALFLVADLAGGGIVALPIAMLQSGSYIGVIIIIALSVGFCYTAHILGENWTIMCERWSDYEEHCRKPYPEMAYRAMGRRAKSICSGILNVMLFGVSVVYLLLAAHIINDFVTSIMGHNIGFCFMIVVLAFVLHPITLLKSPQDFWWAVIGAMFTTVLSAILIMIGTVLDAPICYHARGISEFQASSLVLSFGTFMFGFGGHAVFPTVQHDMKNPYKFTKSAIVAFALVTAMYGPISILGYNVYGDSLESSIINSIQTEWIQRGANLFIAVHCILTLTVVINPLNQEVEHLFNAPHHFCWQRVLIRTVVMICVIFVAVTVPTFGPILNVIGGTSVALTSAVLPSLYNLYLKATVFDESAKKYRRPTLYEIIERTSKMRLTLNVIIIVLAIACGASTTYSAIIDMVSTRFTMPCYLSYLENATSIHENPTHCCGRFKNISRFGDSAKYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URM2</accession>
    <name>A0A0N4URM2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10950</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001296">
        <property type="protein sequence ID" value="VDN60977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URM2"/>
    <dbReference type="STRING" id="318479.A0A0N4URM2"/>
    <dbReference type="WBParaSite" id="DME_0001070401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001070401-mRNA-1"/>
        <property type="gene ID" value="DME_0001070401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867083at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001070401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23444" checksum="A0A8E7ECDDE499E8" modified="2015-12-09" version="1">MQRIYLEAPGQGGAKVKRPSPLAHACSNNNDAFCAALFDLTTPQDLQNNANPTMDYKVNANCQNATLKPEAIRICPRSCAFCCLTPQYNCTNENDQSCSLFLTMPQLCTNPNISAVALAKCPRNCGLCNQPGAGGRCPDTSPNCAVLVALAGCNDTNIQQMCMGTCNIKTCLSTTGGPSVQTCSDDRANCAQMQRYCTIEPFTGTLRQQCRKTCRVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URP9</accession>
    <name>A0A0N4URP9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4134</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000319">
        <property type="protein sequence ID" value="VDN54161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URP9"/>
    <dbReference type="STRING" id="318479.A0A0N4URP9"/>
    <dbReference type="WBParaSite" id="DME_0001073101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001073101-mRNA-1"/>
        <property type="gene ID" value="DME_0001073101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001073101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28133" checksum="0D6934BF3DC0C0F2" modified="2015-12-09" version="1">MAVVRRIILNLRFLLFDNGKFPIKVEIKDVLENIYISVDSAVKLVEGVKLNAVMLSSEISLYKGPPCTEGRCGKAHCFAKLNDYECRCKPNTSVEFCDPSYYASQSRKMAYFDGSTGYSYLNKAVYGAKRQQKISYSFWFKTVASNGLIIWQSNMTNGNNDYLAIFLTNGSLGFAIMLDKKSSQKVLQKKVNDGKWHAASFLRNGEKAELIMFAEKVVIGLPSHNFVGKMSEMSEQTHISLLLILDVWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2N6</accession>
    <name>A0A158Q2N6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS4871</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2N6"/>
    <dbReference type="STRING" id="318479.A0A158Q2N6"/>
    <dbReference type="WBParaSite" id="DME_0000051101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000051101-mRNA-1"/>
        <property type="gene ID" value="DME_0000051101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041047423" description="procollagen-proline 4-dioxygenase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="409"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN54898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000051101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="566" mass="65435" checksum="77D2F808FD596ADF" modified="2016-06-08" version="1">MKFLLIYLFILPSSTQAELFTSIAHLKSLIDVHKEIPEIIESYIKIEENRLQTLQRLIESHRNKNKQMSSDGTNSLRNPIRAFSLIKHLVSDWSVIENLMKQNVADEFLRNLAESRMKQQIKHPTDEDLSGAAAAIFRLQDVYRLSTKDLANGKIYNIDSNQTLSAKDCFLIGRAAYVAEDYYHTVLWMQEAYDKIKKENDPSHEDLQDIIEHLSFSLFKQGNVKRALLLAEELLETAPNHQRAASNIKWYENTLREEGFKPNEFRRNIPPVVNRREDDLVESNKERDIYEALCRNEVPVSIKELSKLYCYYKQDRPYLLLAPFKVEIMRFNPLAVIFRNVISDEEIDIIQEMAQPLLKRATVQNSVTGQLETASYRISKSTWLKSSDHEVVERINRRTDFMTNLEQETAEELQIANYGLGGHYDPHFDFARKEETRSFETLGTGNRIATVLFYVVLLFTFIVFIKMSEPEIGGATVFTSLRTTVLPSKNDALFWYNLIRSGEGDLRTRHAACPVLVGDKWVANKWIHEAGQEFRRPCGLRTFDQEKYVGDLGGPEPENHANISPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2U7</accession>
    <name>A0A158Q2U7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5220</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2U7"/>
    <dbReference type="WBParaSite" id="DME_0000086001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000086001-mRNA-1"/>
        <property type="gene ID" value="DME_0000086001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF70">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="209"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000086001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="651" mass="75866" checksum="C1B4E8E0665A6275" modified="2016-06-08" version="1">MQISKCIVLQVGPYLLDHDTIPEQREFFHSAYSVGSAKQFLSRDQDRWIYRAYECIQAAGEAPYSKSEHPLHYCFGYNSENEKNGAITYGVCMPSICYDDRLKARPHFQILEHWRSEISSDEMPIDYVSCTKSRHELQWFQKPLPLAEFIIHQIFVLFIIIATIYHIRFGEQTGVTSAQVLLSFSAKKNLKKLIEMPKDPQSTITCMFGMRFISMVWTLVGHSFIFVQAYLKNVEEFKDDMVNNFENQWITNFTLSVDTFFVLSATLTAFTWFKRMNKLTSESVPTWTSLGYWLKYYRHRIIRLWPAYIYVMVDVGMRSSLQHFHPMWPPTDPAVQCPKHWWKNVLFINSLTENRCMPWTWYIGTEFIFYAIAPVFLLSLYQTPMIGYFLSLSTIIGSCIARLIAMIKWNFPPTQFLWKQPAIFNPDFIQHHILMYIKPQYRIGPYIIGLLLGHCLANFQACPYKVRRTLRFQVLGWFSAFVASFWAIFGLYPSLQGWDWPTYHLLFGSVHRTVFALSMAWIIYACYTGIGGLINRILSMSFLIPLASLCYTAYLVHMVLVVFTYLIVPFPIIYDGKLTVFLHCFVQLAMSYFFGIIAALIAELPALNLEKLVFSNDRRGQPVCLKNDEIQLKAAVKLKTHFMTVKTLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2X3</accession>
    <name>A0A158Q2X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5397</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2X3"/>
    <dbReference type="STRING" id="318479.A0A158Q2X3"/>
    <dbReference type="WBParaSite" id="DME_0000103701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000103701-mRNA-1"/>
        <property type="gene ID" value="DME_0000103701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000103701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="866" mass="98704" checksum="3062E34FC169FB07" modified="2016-06-08" version="1">MAEILCCRPCKPRYRRLVDAIYPRNQLDGLINSNMQKLTFYAISQPEKLGRIAEYIVLRMSRDLSRQRYNQVKISVEAMDQLLQSCHNLSSLSQFIESFLKMLQKLLETNNLQMEKRATDSFVNFANIEENTPAYHREYDFFISKFAAMCHSNQGENAKTVRYAGLRGLRGVLWKSASDPLQTSIWERQHMEKIIPSILFNLQDDGCFHLFSFDIFKNSYDIDGNEIDTSTGIVFLDQPYAVDGIADSPKTLADQFLRELMAKAPFGLNSVLEPVLKHCDLHEKWNPPPIFAVQTFRAIMYSVKDPCFVIQALIHHLENMSNSNASVRIGIATVLSSIVSIAGSSIGPSLLGIFNSLLKQLRQSVEFQQTECCPSIEEEKIYQETLINTMGDYANALPDYQKVEIMMFTVGNIPKLSDDGQALNPGDAFLQNVLVKTILRVATKYKTSYLATVFTDSFLITMVQLALSADPNVRLDTHRIFQTLLDRHDNLSVLQHLPYVLDVSDLQLTVEKCSRPDQMFMRKHIHLIVNMLYKSVCLVPENDSQFEHMEAILCTMALFCVEVGYDEVLIELFRLSFALQAIALESSSGFSPHKRIAIHNLVAKYLNLSSQLMAIPSLCQHMQQVIQKRISLGYRSLCLLPELNVQNGENTEKIKEQIAVMLEEDASLLFDKNDVAEILKASGKDVQRLAIPFVAKNNALSLLPGNNINNYMVLKNTDKPDAFSGRGISVQDEADENSVDMSIDWSYESIRVSRKNTIFTIGHEKKNITKEPVTVETLRNLLNSPLDTVEEERKEAEKTQQILEMFRSEPFDKLMERNYQRREEIDLSKTVKRLLQKTNESNRLSEYGSGDKPKNIFELKFPSFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3F2</accession>
    <name>A0A158Q3F2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6648</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3F2"/>
    <dbReference type="WBParaSite" id="DME_0000228801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000228801-mRNA-1"/>
        <property type="gene ID" value="DME_0000228801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF19">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000228801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23721" checksum="7E97237074AD9C89" modified="2016-06-08" version="1">MLGDRRNNKIACCSPTTAGVIVAVIEFILCILSVYGLIRNFDLFGQSYFLWFLIGIISILIILSVIILLCYAIKTDNARLLIPHLFVQIFLILFLIIVALVVFLLIVFGAHRGIRRLLGHDSYHMSDEDTEYLGLLIILIYLIVAAIEVVFLYLIYKLYLYLKDYTRVQMNDPFMNNPVYTANWQVPTKRAPNGYGSPDSGDIYPYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3T5</accession>
    <name>A0A158Q3T5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi SNAP receptor complex member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7287</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3T5"/>
    <dbReference type="STRING" id="318479.A0A158Q3T5"/>
    <dbReference type="WBParaSite" id="DME_0000312801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000312801-mRNA-1"/>
        <property type="gene ID" value="DME_0000312801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823029at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000312801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14495" checksum="9AD4AF880747B14B" modified="2016-06-08" version="1">TFEESRRLQESLTKLTEILQDKSKGDEIHTTKIYHQPDVGMLYSTNRQLEHELEELTSSSRRSTLRRHYTPGDYLKYNSETEGYGSLGRNRRSLSASALGRGIRKIRDIYEHSYLSSGYIFALCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q497</accession>
    <name>A0A158Q497_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8184</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q497"/>
    <dbReference type="STRING" id="318479.A0A158Q497"/>
    <dbReference type="WBParaSite" id="DME_0000430101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000430101-mRNA-1"/>
        <property type="gene ID" value="DME_0000430101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000430101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36080" checksum="837F852ADF433AF7" modified="2016-06-08" version="1">MDDKSVKQRKAEQLRKIIFLGIAISTSVTLICIIVAPLLYNYVQRIHTALLNEVEFCKRRSTNMWDEFGHTKNILGIPSTQRRRRQTHYIDAMTSGARYGQKYRHRVNSPAYQPKGIGYGGLPLIQVSPARMPSTGQGCCSCGIGDAGPPGFPGTPGENGLDGSPGRDGLPGPDARDDVDYKEQEWCFDCPVAPQGSPGTRGPKGPRGPPGQQGLDGRPGEIGQTGAEGPRGTPGPRGPRGEKGAPGLPGQRHEMPGGKGRPGRPGPQGLPGFDGEPGVDGTEGPPGPRGQQGTAGLPGRPGNRGLNGSRGEKGTQGRVGSCDHCSLPRLEDGYFLSRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4E3</accession>
    <name>A0A158Q4E3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8541</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4E3"/>
    <dbReference type="STRING" id="318479.A0A158Q4E3"/>
    <dbReference type="WBParaSite" id="DME_0000465801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465801-mRNA-1"/>
        <property type="gene ID" value="DME_0000465801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="13"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19973" checksum="1C9602AED0EDEEFD" modified="2016-06-08" version="1">MTFDLDPSSLYNIKALAILDQDGNRILAKYYDPDVLPTVKDQKAFEKNLFQKTSKANAEIILLDGLICVYRSNVDLFFYVMGSSDENELILVAALNCLYDSISLILRKNVEKKALVENMDLAMLIMDEICDNGILLETEPQAIISRCALRSDDLIFGDQTISQVGMSVSLIEKVHETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4G2</accession>
    <name>A0A158Q4G2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8670</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4G2"/>
    <dbReference type="STRING" id="318479.A0A158Q4G2"/>
    <dbReference type="WBParaSite" id="DME_0000478701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000478701-mRNA-1"/>
        <property type="gene ID" value="DME_0000478701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000205">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000478701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29487" checksum="D0883320F57C61CA" modified="2016-06-08" version="1">MEEEIHGGFYEIGAYRHNVRRYKEGIEQLNDIQSMLKERADIESSYAKSLQTFHAKWSNYVSHLPHSTIKNVWTELLEEGSEVSKLHANVKDRISDELLKTISLYLKENHHPTAFRAPKEIREIEDDFEKAQRPWRKHYEKAEKAKKAFHLASKAERSAEIQAKNASGDSSISTDNENKFRERYQKCQGELAKSEKAYRVAINDLISLKANYISHMEDVYENCQQKELKRLKFVFEMLCGFQKVVVDVATATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4P2</accession>
    <name>A0A158Q4P2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9115</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4P2"/>
    <dbReference type="WBParaSite" id="DME_0000531601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000531601-mRNA-1"/>
        <property type="gene ID" value="DME_0000531601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855762at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000531601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40154" checksum="1DC88E9315142FEB" modified="2016-06-08" version="1">MICDSNNSITPNSAEEKVDVDEDHETRIKLAYICDDWIFDSLGKSFPIDYTEEKQQQQQQKEEICVKHIINSDMDNENIRKRLQLAMNETKKLRYRLYSLIVTARAELKKLNQEKIQLSHKLNANFIIECSSCKSVNNIRKNSMKPKYLKIFKGRNAVELLFDNYQNLQKWLVLNNLDEWDGFSFLNENSRRTYQTLESSGSLIAQKTDEIFRKHNIQAARNACSSANSSRDSDMTLNLPSYKSSFWERKKATNKNKSEFRSNKEINHFSLEKRQSTECERNAANVIPKGNECQIEATKKQFKRRKPNRSENLHENGCERNSPGRNEINRKEKMIASNENGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Z3</accession>
    <name>A0A158Q5Z3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2561</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Z3"/>
    <dbReference type="WBParaSite" id="DME_0000864601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000864601-mRNA-1"/>
        <property type="gene ID" value="DME_0000864601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5787168at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056656">
        <property type="entry name" value="DUF7754"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24937">
        <property type="entry name" value="DUF7754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000864601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="69639" checksum="E66AFF41A61DDB7B" modified="2016-06-08" version="1">MEGSNDEEKSFDEQLSHLSAKTCEELFPNFIPLPSTGYEISFSLYCCEYGLIEGKFRKAGGIHFQMQFVDFIIAQSEESTNNSMDKNSIVHFFGESTDLNLEWRYIVQMRFRVASDVDNLEQVVDGDLFEFGRHCPPIRLQLTDPRIRRICIELRFVEKMHDFLPKFDDGDIFLKFNDGILKVHKALLALHSNYMAMTLINAKKDDIIYMDEANMEDFKEMLYQIYPTTRPINANFEKLSKVAVQYQAEAIIENLSSFFIDNNKKFIEQKIGDAARLNLQPAIERLVYDAEQDGLWAKMIHTGFNPKQEYGSLIYDEIILPTVAKASLLFEKNFIFYLSAKLNPIGVPLKTKVFEKITFRSKAESEDPFNIPLFVQGIPFFVNRGILAINNDKRFGRGNNGELIVQINIDFENECIKAGKTPVDVVHALLLHIYPMKEPIPIDIVRPMLALSHYHDMHYVMRSLEQVIYRFYLLKEPPESSEHFFEHFELAEKYDLENLLLRSLYRIEKSCNCFVKKMIELPCYKNLTTKTRNRILDRFCSNWSVGRLNPSRCINQFIPIILDKANQSSSENDESLATLREFSSHSVFGDPDDIASSHSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q699</accession>
    <name>A0A158Q699_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IRG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3204</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000113">
        <property type="protein sequence ID" value="VDN53231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q699"/>
    <dbReference type="STRING" id="318479.A0A158Q699"/>
    <dbReference type="WBParaSite" id="DME_0000951801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000951801-mRNA-1"/>
        <property type="gene ID" value="DME_0000951801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000951801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="554" mass="64387" checksum="D70F27C83769D7C9" modified="2016-06-08" version="1">MKTVDNYPIYDPVNELNFHSGKSFQNLCYRVDTTKINIGIAGRNRTGKSALINAMRGISYGDQYTAGRYPCERMEPFVFIEEEFNWLVLWEIPYPRKFSGSVDVYERNIEHDKLYESNKLYLFEIIFVLIDDGKLHDDDIIFAKILNSRRTSLVFLSTKTDNVLDAESRECHLEICDKLKERFLEKGLNRLLKFLCKCQSLEDVEMLYINAPTIKCIVNGNTDYLHYKIDEIRLLDIIGLKPGCHYGLENLLQKQKQKNVFKNLNRNVSRKSSFELCTYGCNRTTVLADAGFQISYRIDDRIYDYSIKYGIRRAGKTTFNYAFAGESRAGKSSLINALRGMSMEHPLAAGRRRNKFGECERFDFDDDVLAYNVTLWELHYPKKINAFFDFIDRYKIATFTAVFILISRVPSDQDLTFAKIAFRRNATIVFLLSKCDEKLMKRSRNEEIPICDFLKQRFVDKGIVRFDRSLRSNAPELCGRIHLFFISATVFMSLRLGNDASTFLLHERAVFDFLKQKRLVSEMLQSSTGRLNDNLYANIGDNDSQVEFLIPQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PUC5</accession>
    <name>A0A3P7PUC5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ODC1 and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PUC5"/>
    <dbReference type="STRING" id="318479.A0A3P7PUC5"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="143" mass="16249" checksum="8007E7D34AB6FB63" modified="2019-02-13" version="1">MASGVAPDDPNELFYNQEKVTTLEGLIKGVSPEWGYDLTDRETLVLILPASQPVLTISKVAFVSLLEFCEDELLVKRVIISIDKGKLTKEVLVAYVFFIRQYDNTLLSWAICYKYIGFTPLHPEHCPSSIDPEKNFSMIYNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYC3</accession>
    <name>A0A3P7PYC3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYC3"/>
    <dbReference type="STRING" id="318479.A0A3P7PYC3"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="54"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="191"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="599"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="701" mass="79668" checksum="59D7CEFA93F628BE" modified="2019-02-13" version="1">MKSAQRQEKTAERRKISEDDRINAAIVIQSGWRGHRVRKKYKTKSDELTPQNAMAYTILVVIGNRWAAETDQDLFIIIYGEHGKSEKLYLRQDAYEAKFRQNSIDSFHVKIDALGILDKIILGHDRIGYGAGVFIERILIAENIVDGRQFLFQCNKWFDSGQADGKIERTIKITAYYFISSMPDDPNSTKGRWELIIYFGKEDGTGWTTSNLNVIGYGSHGSSATNKIYDSNFTKAPSQALIQVDFGDIGDLLKVRIEIDGNGINPDFFLNKVELKDLDTDEKMVSIVKKWLKFSGAEKYNQPFREFPVFRTALEPLCLLNYEGRLRLGNRRNIKTSLCFMQIIGELSETGKFPINIDRKHSSKSKCFLYHSLKIEVPSLISQLIALEQFRRNLPCTPEILFKAESVYIGRIHSVRIYVDSTSIGEQLYEGMCMLQTIYDNRFVPHIGVGIEWLVERIVIRESSHTPYRFMLGYSRVRNAQEENDIYKELVLSGMEGLPTKISKKKSQKKLCAQWILSITIGEQSTLIPKVTLCSETKNAEMVLVSRTATDGIINFQIVLYDSANGDEPRFSNVGAIMTSECVVEYAAVWPDIPPIPYVNYEITINTGELSGNFIVYLNLIGTKGDTGFRRLVNNETNPLQADSNSVFQVKAVSIGDAKMAEIALRSEKTPILWSCEQIHVLDNVTNLFYVFHLKKLVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q1L1</accession>
    <name>A0A3P7Q1L1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001208">
        <property type="protein sequence ID" value="VDN60275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q1L1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q1L1"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="65"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="228"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="78634" checksum="3F081FBB56F1B7DD" modified="2019-02-13" version="1">MLGFQMKLFDYIWRRKTLSNSMVDHFNHWFYYNFFFFSIISSCEKSDFLLTFFKFLDWQKECLSDQRLLNGSNMVISLPTGAGKTLIAEVMMLREVVLRQRNCLLIVPYVAIAQEKDISNFKFYWCNIGRLPPVKRRDRCSIYVATIEKANILINSLIIEDRISELGVIVIDELHMIGDGARGATIEQILSKFLFKGNSHFIKFRYLFIHIIIYYIDSLKFEKRDPDGLISLLQDIMPHNSVIIFCPTKKNCENVAKMIASVIPKTMRQQKIKEKADILNALREEQDGQISSILEMLILAGVAFHHSGLTADERRIIEDAYHEGIITIICSTSTLAAGVNLPARRVIIKKPFVGIEPIKKAQYLQMIGRAGRPGFDNLGESVTIVHPGHEADTFFEMLASPLSSCKSALCDEELLSSFILDLICLKGLVLSSQFHIIFILIPFDIYIEIDWHIFYDEVRILSFIIYKAIRLYITFMMLRIWNQESFSCVASRFRVTRGWIQSTLQSICMQASSIARFCEKVPDLWPLKLLLPDLVQRLRQCRQQELVPLLAIEGVKTGRARQLYEKGYKTVGDVAKADPNTLVHQLMHLNRKQARLIVRNAQVYFSIFNFIYKFIYKYKFKPFFIYKFSHLMKKIAHLKSRLMEVFLLINEPSINIVKLKKFLASRLKLKQKRKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q257</accession>
    <name>A0A3P7Q257_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7496</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q257"/>
    <dbReference type="STRING" id="318479.A0A3P7Q257"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="163" mass="19206" checksum="CB34907DB397C523" modified="2019-02-13" version="1">MYSRFLSLDKQGRGYLDRDDFLRIPELAINPLGDRIVDAFFTETIKDDNEQKINFREFIRVLARFRPVSKSKYNHLNSREEKLKFAFSMYDLNKNGYITREEFKIILNMMVGANITAEQLESIADRTITEADMDNDGKISFSEFCQAMEKTDIEQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q3X1</accession>
    <name>A0A3P7Q3X1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q3X1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q3X1"/>
    <dbReference type="OrthoDB" id="5877455at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="214" mass="25660" checksum="0B27BA03A5E83510" modified="2019-02-13" version="1">MNSSDDELKVFRRLQDANLFQNIKGERKRKFRSEFIDEEASLSGEDIDSDNEDENADLDEYEKEEGDEDDVPDEETLKLQLSKQWLKEQQVDAEDRKLLYWKEKLFVDGDLHMDTDRTFRLKLRDEANMNDQASCENETGPEDVDDEENEENYDAMKRHIEMLKWKLKTDVSSVKKLDYFRWHFCCPSIFAIFLTKNDFLISIFHSIFFRIHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q4N6</accession>
    <name>A0A3P7Q4N6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q4N6"/>
    <dbReference type="STRING" id="318479.A0A3P7Q4N6"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017991071" description="PARP-type domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="220" mass="25579" checksum="6053EB2482C3F3EB" modified="2019-02-13" version="1">MLHFLIRYLVLLEIRMAKIVPNPFISDSNNPVDMKQYFHVECLFETFTRARLSTKVIESSDDIEGSYFINDDDKAKILEQINNLDEFRKEIEKNTGDELSNVSKNSSQLAVSPEFPSKESVKNNELYRQEKLSRKKENDSQKNNFRSNEKSNKSKFDSFKVFCKLCDVIARVSKCSDKSTAIHMFITRGNNYHFFFCPLSDHTIPDSTHSYSLKFVGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QAP8</accession>
    <name>A0A3P7QAP8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QAP8"/>
    <dbReference type="OrthoDB" id="5873061at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17658" checksum="90EF5D503985A134" modified="2019-02-13" version="1">MISALSIFNYSYYYCYKYSPLSCMTCINAQHDTTQLDKFRVRARLTVPKCQMEPIICDRDQDVCVTITMHIGVDHYWIGSGCDKHENFQHIACENVHTLTRNVQIGIVQERRALQRVCVCTTNLCNHIAINQSSILLIFICALIFFVYYNSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QH06</accession>
    <name>A0A3P7QH06_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000257">
        <property type="protein sequence ID" value="VDN54067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QH06"/>
    <dbReference type="OrthoDB" id="5855340at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="133" mass="14859" checksum="6831B16768D2920A" modified="2019-02-13" version="1">MNFATECKNPLLYPIVLARCPKTCGLCDRPGALGRCPDSHPICPQLRLFGNACQDSRIAQMCTTTASARSLVLCQDRRTNCVSYAPYCNHPRYSSVLRDVCPRTCRVYHSPLLVGLTLLACRVGQICQRLPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QN87</accession>
    <name>A0A3P7QN87_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QN87"/>
    <dbReference type="STRING" id="318479.A0A3P7QN87"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="348"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="523"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="829"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="135005" checksum="459332FDBF432896" modified="2019-02-13" version="1">MFRNAMISDYMKQRAAICAKLYYRHKTETQPIIFKLHQSTMYLILSFLCKANAKATVDYKKYSAAVKNRDYKSKRFSDIDSHFTGFYNYRKSTNWRKNRKTTIRVETPVPENRNNEKDFDKVEIVQSEDIEEVAKVPKPFREAKRISCSKTTAYSLCFFVFIAIILSSLITFWITKDIYNRQSQSLWLQNDSESEKSETVSEQLAMVEDELDAPAAEELRLPKNLIPLRYNVTIKTYVPGFADFHEGKNLTIDAAAIIIFRVEEPTDKIVLNAYKLEFVDDSTKYKLAQYIEREPVEYEDTIETHDANFGNATANNEHDETADISTSILESIGQSEELEDETTLPSHFLVEHALEPIEITKIVVNETLQMVIFQLNEELKKGGEYHLKLLYKGLIEKEFAGIYLSQYYDNSGLSGFATVAQARPNNARRIVPCFDEPEFKAIWKIKIIHPKGTTAISNGKEIHDALETDDVNWLSTSFEETLPMSSYLFAFIVTDFPFNEGVTDKGVRFRIWSRKEVLSYTDYALKSGMKALEFFEDYFKIEFPLKKQDIIALPDFAAFSSDSWGLSITQEQNILYDSNLYEPFIRIRVLLTIAHELAHQWFGNLVTMKWWNDLWLNEGFATFVQYMGADAISSKKFRLDEYFLSNTLRRALQRDARSTSHPLLYPIDKAEDVIGAMDIITYDKGASIVHMIENMLGKENFRKGLKIFLEKHKFANADHDDFWESFNEVLPNHLKAWNGDKLDIRKFAEHWTEQMGYPVIEVHRLDARTVELQQKRFKWNGNTLEKKKYRNAKYWYKYEIPIWYQINSEEKPMTWLHQAKSLQVKPNDLFILNSQSRGFYRVNYDHTSWERIRQQLLEDHTRIDVKSRARIIGDMFALAQTGMLPYDLVLNISKYLVKEKDLLPWTVAMKGFDEILNIFGDEPETQAVRDYLESILQPIYDTNDWSKLDNTNPFFENELEAIIIHQYCKIRAISCINRLADIFKQDFLEHCKDNDISSACSRVPIGIRSKVYCEGVKQNVEQIWDKIKGLYERETIQVERKRLLRALACSRDPMALKTLLDSALDVNNSLILLHDAPFVFRSVSKGDVGRLVIFNYFLDNWPRIYNALKGQQLFLKSIIRSSIDLKHERDLEQIWFDENFDKLYAWFRKIKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QRJ1</accession>
    <name>A0A3P7QRJ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QRJ1"/>
    <dbReference type="STRING" id="318479.A0A3P7QRJ1"/>
    <dbReference type="OrthoDB" id="5845882at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="252" mass="29099" checksum="818E6DA2331F5749" modified="2019-02-13" version="1">MVLGASTVISEISLGSHALNLTLNWLCNVATFENVHRRTIIFAFDDYSYGKIKESWPELNDKQFHVGDGRYQMFQLFRSNLCSYLAANGISFWMLQADTYWRENLFDVIGSLLADMIAGGNFFVKAGYRSTAFFNELSRRLLNYYSTDNNIMGALCRTIFKGSRCSFIPYQIISNWRWHTMKDKKLPSLMQFDGGATGISKFKRMQDLGAYFVKSETIGRHQTAKCNANKIREPKNAISMKYFILHHFIIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SB08</accession>
    <name>A0A3P7SB08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SB08"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="123" mass="14114" checksum="8C4D96E519661AC1" modified="2019-02-13" version="1">MRAAARRKNAALAYLFAIPIASILSPKTLRVVQSLLIPYSQRNIHLKSHFYKETGRIVNLFSGGRVLGKCSLIVGVIFVGLWRVVVIRSKIVELALFLRLENIFRKWLVKKERITMKLLRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SCP1</accession>
    <name>A0A3P7SCP1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SCP1"/>
    <dbReference type="STRING" id="318479.A0A3P7SCP1"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="196" mass="23401" checksum="5057BD3D74DD040B" modified="2019-02-13" version="1">MREFFDNEQNFGVNELRPSKRPGRSWSVDELRLKSNSDLHRLWYVLLKERNMLLTMMEAYSLAAHHFPNPERLDRINESMKNVEEIVHERNDAFFLLETGQGADPPIRSITSFAGFTYKKFATEHYLPAEITGEKEYEKPYLDDDAYMMQKLWAEKEHAKKRIALSETKRRRNLAENMIRFNRSARRLVNRVEHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SX65</accession>
    <name>A0A3P7SX65_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Renin receptor-like C-terminal transmembrane spanning segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SX65"/>
    <dbReference type="STRING" id="318479.A0A3P7SX65"/>
    <dbReference type="OrthoDB" id="7866065at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056780">
        <property type="entry name" value="Renin_r_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012493">
        <property type="entry name" value="Renin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13351">
        <property type="entry name" value="RENIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13351:SF1">
        <property type="entry name" value="RENIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07850">
        <property type="entry name" value="Renin_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Renin receptor-like C-terminal transmembrane spanning segment" evidence="2">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="209" mass="23719" checksum="ABB51A4B67CC6EDF" modified="2019-02-13" version="1">MLNNEVNPSSIDHIFSTNFAENRIWAKIESKEIKGSNVFSDIESVKFNETMISISTMPLRRELILLYKLSEAVTKSLVSLSPALYIVQIDGLESAKIEAPLDYRNAMRELIEAIIYFISNLKNSYGNRAIVELIIRTNGDNTHSIEKRQVSVLIFQFTSEDYPAMFAIFAGCGIILSVSVFFIVVGLWNMDPGKDSIIYRMTTTRMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T0D4</accession>
    <name>A0A3P7T0D4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T0D4"/>
    <dbReference type="STRING" id="318479.A0A3P7T0D4"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="467" mass="51122" checksum="320348891E92B85A" modified="2019-02-13" version="1">MEPTNVFGLSSASTSSASMNAMLSGTTGLAAASAVTGLDSAALYQAQSASLAQGSSSQDYVMSSYPASLNPYQYGQYPSTNAISNGNLPSYYTPNYMTAGSQIQPSYNSFGMAVSPLSNSRNSSINSSTAAGGSTSSSVQQQSPNCRTSRVTFNEQTQAELAQMRTYNGKIGNAKPPFSYISLITMAIQRSESRMLTLSEIYQFIMDNYAYYRQNQQRSAGWQNSIRHSLSFNDCFVKVPRTPDKPGKGSFWTLHEDCGNMFENGCYLRRQKRFKIADKQKNRKHGHSSRSNHIKEEQETEAADSKLPRNNEAKMNLVPAPAITRSPPSEAETNTGPNIDQSVLLQQSLQNSTSQQDITSEQIASSTSSQRTSANSQPTSVISAVGTVPLNPYATQYPSFGIYSNNSVSGMTDLSQSSLPTLTPAAFRIGNLIDNYSVYNNMYTAQPSTNLNEYPYQQTIYRFFIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T1J3</accession>
    <name>A0A3P7T1J3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoacetylglucosamine mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T1J3"/>
    <dbReference type="STRING" id="318479.A0A3P7T1J3"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="9">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="8">
        <location>
            <begin position="208"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="6">
        <location>
            <begin position="379"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48819" checksum="9BF689A38069489B" modified="2019-02-13" version="1">MDFTIHDFSIIPDRYTRLNNRDHLGELVRVGENMKFEYGTAGFRTNAKYMPFIAFRMGILAAVRARNLMNNTGLMITASHNLEEDNGIKLIDPTGDMLEETWETIANNFGMVTSVYSKKLNIDCANGVGGTKFKEIMVLAKGLFEINLCNIDGPLNYKCGADYVKIAQDFPINMENIPIAERCASFDGDADRIVYFFRNKNNKFQLLDGDKIASLIAIAEANLEKKCTIGVVQTAYSNGSSTKFLTEELGLPVSIVPTGVKYLHKEAHKFDVGIYFEANGHGTVLFSERFLSEIHSNTSNQSVCNLKYFVKIINSVVGDAMADLLIIESILKYYDWSIEDWALKLYVDRPSCQIKVKVRDRSIFKTTYDQLTCLSPEGIQKFIDEKAVDGSRCFIRPSGTENIVRVYAEASTEEKAKELADLVAKEVGRIAADHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TA36</accession>
    <name>A0A3P7TA36_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8872</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TA36"/>
    <dbReference type="STRING" id="318479.A0A3P7TA36"/>
    <dbReference type="OrthoDB" id="5821696at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000034">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33802" checksum="2AF55BCD7996D577" modified="2019-02-13" version="1">MSKLSDSDSQTLSHMVIQSIFTSSYNKNTVPSAKHTTKVTIEFVIQSIGQVSEISSSFTMDLLLSQIWHDPRLRFDHLTTCLKNLTLGHKMVEKIWIPNVCIVNSKKTAIHSSPSPNIFLMIYPNGTVWINYRLKVQGPCDMNLELFPMDIQVCELVIESYSYNAAKVSLIWREWNPVFSIAKEKLADFTLYGIEWKKNSFEYAAGQWDQLTVSLSFSRAYGFYILQMYLPTYASIDFKALPARITLGVSSLMALTFQYASIAKSLPKVGYIKSVDIYMVMTTGFIFLSLIEVAIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TAD1</accession>
    <name>A0A3P7TAD1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LTV1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TAD1"/>
    <dbReference type="STRING" id="318479.A0A3P7TAD1"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="333" mass="39398" checksum="F1CCD05DC05F5502" modified="2019-02-13" version="1">MQLKKIVEKNLVFIFLFVLVYRCTKDEIFIIFLFKYFQPKHKKKWINGKNIVKFRLKNICDIFQDFEEHMKYGIFFDDDYDYMQHLRSLNERFFKFKFLNHPDIIFLVNDFFKDVVPDPEIVAALDGNFDFDNPENILEDDFILKACDGELPPKMPTKSISDADFEIRHPDTSSESDDENDVNDEMDFDDFSVEMEADAVDSNEEFNQIEVEASGPKKVDWDCESILTTYTNIYNHPTIIKDPCRKRKIKPSNDIEVNINMVDIDSQSLASTRTVSTMRPPGETSEERKLRKNAIKELRRERRAEKKSNKLAYKKERLKLFQSGTQVKMRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0F6</accession>
    <name>A0A0N4U0F6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4394</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0F6"/>
    <dbReference type="WBParaSite" id="DME_0000003401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000003401-mRNA-1"/>
        <property type="gene ID" value="DME_0000003401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825164at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000003401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34661" checksum="1601037BF787AA7B" modified="2015-12-09" version="1">MGVATNTLAICTILISSQLHNAFGYISTSQSTANIVVSLIFCFWAAPLALNPIPGHLILFFWWVALFSHFAIACNRLIAVTRPIRYAKIFSTRNTKIVLIFVWAIPFLYSLIYEINGCNFYFNRLTLKWEYSETACGQMLSTYIDVIICYMMIISVLTIDITTYILMKRFNSHVRFPVHCPSDSNFTVQKVANNIVVKGASYIRRKKEISFYIQACCSISVYLVTVIFFYGVEGYIDSPIISFYMSTFLWEIVHMIDGSNERSFPKMPEERITTYSDKPQSLTQSRLPSLLNPPLMPAIPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0G5</accession>
    <name>A0A0N4U0G5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS4405</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0G5"/>
    <dbReference type="STRING" id="318479.A0A0N4U0G5"/>
    <dbReference type="WBParaSite" id="DME_0000004501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000004501-mRNA-1"/>
        <property type="gene ID" value="DME_0000004501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="20">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN54432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000004501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31596" checksum="4FDCA34D38E2B961" modified="2015-12-09" version="1">MYAIVSGVEFRNECFCGDFYQKSSEVSDSLCKQYLCPGNNTVFCGGYETIAIYSTGILGKPLNPIKYIEPDVSSSHDIRILFLLQLNGRNIRQFLEMKKLESKISEAGYDNVYVMDKRYATIWGGANLLSMVLEAINTTLLMNNWASWDFLINMSESDFPLLSLMELETHLSRNKDRNFLSSHGYDTARFIQKQGLEYLFLQCEDRMWRIGKRCLGNFPHPIRIDGGSDWIIINREFASFAVSNDPLVQRLREFYVNVLLPVESFFHTVFCSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N2</accession>
    <name>A0A0N4U0N2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF1907 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4478</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N2"/>
    <dbReference type="WBParaSite" id="DME_0000011801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011801-mRNA-1"/>
        <property type="gene ID" value="DME_0000011801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33012" checksum="7704A3BDD02DB551" modified="2015-12-09" version="1">MFCNWTWIKGILWNDSGGYRKMPSHKYQVSDFRQAPYLMTGSGIGSGLRIVEVGGIGNIYPVIKCDKFFDLKAICTKSDMPNAFVFGPGAGPWHVIGSNCEMVADANFVNPSNPVIASKIIKINADNKAYELSTTNSSYFSLMANLALSNANEPADVVHIHVKKRLTDTNFPESVRRTVGAYYGKNLVSIAGIFLVKAGKIKMHVMPNFPSPNYCWKSADEVREWLKYFEMSAPVICACVIHSTNNEERKLRMEHTHCYSEHGDGGHYHCDLSPEIVEYEGYFAPAESVYRIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0S7</accession>
    <name>A0A0N4U0S7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4528</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0S7"/>
    <dbReference type="STRING" id="318479.A0A0N4U0S7"/>
    <dbReference type="WBParaSite" id="DME_0000016801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000016801-mRNA-1"/>
        <property type="gene ID" value="DME_0000016801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123971at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000016801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52225" checksum="315B162944272C85" modified="2015-12-09" version="1">MSSLDSHERRELDNGNTIIELEKRENGFGFSIVGGIDNDHFPGNFGIFVSKVNDGGSAAESGRLKEGDRIISVNDKSLVDLTHDEAVAVLRNIPVNERAVLLIEPDAERNEIYLKYCFIIGIALHYVQQVFALCTSFSKTKSLLKFSKVEKIGYAFLVPHKSSYIERFIFIIAQPGKRSETSALTLEKNIYKTKTDKFEKPPNMATEEPTNIIQDTFQEYTQLNFSQNSRPSLNANRTEDIEKSEYISDSILDISPLKVDYFTFSPIAISLTEQPFSNTVYNIDKLLHAKKLISKDSTAKGLNHVVHLSGSRNTNLVENKEISSTVIFHSESGSGVQSDHVHLFSTKKRPVRSCSLIFNSDDRSFLPDPSIYSEVMEKFKEQNMEEQTEINREELSFSFDVTEDYADSAVEQKARSPIILDEEKENDELSQRAIIDDIPRTPKRAVITSFLDPMRFYLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0Y9</accession>
    <name>A0A0N4U0Y9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4597</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0Y9"/>
    <dbReference type="WBParaSite" id="DME_0000023701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000023701-mRNA-1"/>
        <property type="gene ID" value="DME_0000023701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000023701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19291" checksum="16C87A88B736A58B" modified="2015-12-09" version="1">MLDASDVYRIADEVKKRGKEEYLATKRLVQRILNMIQEQFHRKVPRFFSKDELLCSLGLNFTIAHGNQSYGSPSSFSRLYDYSTGYLQNNGQNQRQNYKQSLEVFSNMPKSDRRFLYDKILSSKSSTINIYSHLNTSFQEEKVKGAKKKDVAECTVWSRMITIGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1V7</accession>
    <name>A0A0N4U1V7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4979</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1V7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1V7"/>
    <dbReference type="WBParaSite" id="DME_0000061901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000061901-mRNA-1"/>
        <property type="gene ID" value="DME_0000061901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000061901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34067" checksum="8A1569A9DC67F5B0" modified="2015-12-09" version="1">MLSPEIAAKYYCKIIQESPIEKSASLAVLETLLKCIQLTKASTVTQLLEELKGAAEAMSKTEFGITSVHSSTELFLRYISFVTAEQNLQEFGDLLNLYKERGGYFIERISRSISIISSTALMSIKKKKNILTHSFDNVVLGVLLHAKQNGANLSVFVTEGRPDCSGVKMVKKLREANIQTTLLLDCEICSVMESLDVVVIGAYGVMESGGILNKIGTLPIAICAKAMSKEVFVMAESIKFLKDFPLNQSTISNEYKHPVSNITKRELGDATERYPLVDYTPPSYINLLFTDLGVLTPAAVADELLKMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U290</accession>
    <name>A0A0N4U290_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5137</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U290"/>
    <dbReference type="STRING" id="318479.A0A0N4U290"/>
    <dbReference type="WBParaSite" id="DME_0000077701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000077701-mRNA-1"/>
        <property type="gene ID" value="DME_0000077701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5915751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000077701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="894" mass="102217" checksum="5C84F76765B15F6A" modified="2015-12-09" version="1">MSRAVENGKAILIGNENDILHCGYSHALSDGGKRYPSADHYAHSMILTQLGLDEALILELLCTSSADVPIKARQLLEENMPSGHDMNSLSSYLQTSRQSYTMQGLRLRVEQDAAFERALLDTKDALLIVCDARDSELGIGMDEDAFVDWMAKEKVDVELLGHWMRNERGRPSNLGHNQLGYFLMWLRYEVTEKKRALLLSTQPIEVAGISTDQNGETVRITISDLVISLQGIFRPLSNYFALPFEMKGERYRSVEHYAYQRLFEALRLDDKLIEKIRTTVDPLDITKVAKRVFKEQQLTPNAIESKLARLDRWRQSAMKHKMTKNEGLQQLLLATGYAILIDCTEGGDSSWISSMDELEIQHLLTKQYITPSLIIDWMAERSKPSTTLSHIKGNKTGLLLMELRSKFAASLNSQNRIPLVSPLATAHELRTLLSSHVICFTVESVFHFLYPAEIRIPNTNEFFPSPSHYIANAAIKYFNFCKNDAEWIMETRKSIECWYRVNFMIEVSSASFDKIQGWYMDERQRAIKAALALMFEQHAPLLRALLDTGDALLVYCARFSSLECELTIGMRERDLRAWLFHVDIDTKQLFDSILRPLAFRPPYLGGNRLGCILMELRRGFILRGIFPHQLPELQIGVDVTLASDSPTENYFTAIPFDVLDVNNFTALWANPFLLLAKQKKDAELLAQAHSQKTAPKLVSVNDQKLNMLISEIDATDKIKEKDMEFYAIEDLRAIFLRLAVRMQNRLNETDAQQNEMNLLAKEITQMQNIKRSLEERKLQMDGRSQERRDKREPLPPHRPSSPSQTSHLSSTQSSLSVPPVPLLIPYSISRKWEDRRRFGRRYSPEEKILRRRSPLHLKTFPVSPPKNSPSPPKQTPQKGTVDESELSEGEIVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4L2</accession>
    <name>A0A0N4U4L2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6089</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4L2"/>
    <dbReference type="STRING" id="318479.A0A0N4U4L2"/>
    <dbReference type="WBParaSite" id="DME_0000172901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000172901-mRNA-1"/>
        <property type="gene ID" value="DME_0000172901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF17">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000172901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16839" checksum="6ECFE49461380C84" modified="2015-12-09" version="1">IHQQHAPSQPNTPPSGAQQFGGQEAHNAEHIKEHLEGKVDPTVNMTQEQLQFHYFKIHDRDNDGCLDGTELIKAITHFHLENPDPLHKHDNQPPPLPSEVQLEEMIDQILGHDDYDGNGCISYPEFSKAQKDREMQARQHQSSSSQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4P4</accession>
    <name>A0A0N4U4P4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS6124</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4P4"/>
    <dbReference type="STRING" id="318479.A0A0N4U4P4"/>
    <dbReference type="WBParaSite" id="DME_0000176401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000176401-mRNA-1"/>
        <property type="gene ID" value="DME_0000176401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000038">
        <property type="entry name" value="Glutamate-gated chloride channel alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000084">
        <property type="entry name" value="Glutamate-gated chloride channel subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="202"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN56151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000176401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33655" checksum="A50D06B0972DB646" modified="2015-12-09" version="1">MKLQEFIFNQFRFEIAYFFSISKIDDVNMEYSVQLTFRESWVDGRLAYGYPRDNKPDFLILPSGQQIWMPDSFFQNEKQAQRHMIDKPNILIRVHKDGTVLYSVRISLVLSCPMHLQYYPMDIQKCLIDLASYAYTTDDIEYVWKSTDPVQLKDGLHSSLPSFQLNNVTTTYCTSQTNTGTYSCLRTILELRRQFSYYLLQLYVPSTMLVIVSWVSFWLDRSAVPARVTLGVTTLLTMTTQSSGINAKLPPVSYTKAIDVWIGACLTFIFGALLEFAWVTYISARDFHKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4U6</accession>
    <name>A0A0N4U4U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6191</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4U6"/>
    <dbReference type="STRING" id="318479.A0A0N4U4U6"/>
    <dbReference type="WBParaSite" id="DME_0000183101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000183101-mRNA-1"/>
        <property type="gene ID" value="DME_0000183101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000183101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17989" checksum="327AA3C08CFC03D7" modified="2015-12-09" version="1">MEKLNDSDSDNEMDYHTYEKKREMNVRQIVILDRLFTNAKKDLYKERLNQLERRQTELVDQRAPDYLSKKAVLAEEYRVKKEQLQALRRLQIEALRRKTVGTLEMEQKNLVHNRKLVYEQIEEDIEAAVAHLHEERERCYNDLEKLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U541</accession>
    <name>A0A0N4U541_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major sperm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U541"/>
    <dbReference type="WBParaSite" id="DME_0000194501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000194501-mRNA-1"/>
        <property type="gene ID" value="DME_0000194501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10674088at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000194501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39118" checksum="354AC54D0DAE3DC3" modified="2015-12-09" version="1">MVKENKIVHKLGNSMAEKILASQTINFCTVDAGTTVKICNKFIHPLNGILEYVLYQKEKAKLIIRDCSGKRVLPKTPKRQNRTVKVAARIGAFVEELSAIDLKSKPIDEADGTKNELSETSVHQIPAHRSKGMELRSHCCPCPSTPKTPISVLGESSKLPCTPIRTCNNMAKDFGARKITKTPVRNEHSTNLKAGNAVRKSAIMRKLEEKARMVIMNKEEIIREKVERAKRWCLNEDGCDHVIFCLFDGPVKYTLDKSGQKPLKGYRPYGRLPVFLLKAESVLSDMIVATPFCPELSDAPQPIPLFRVKITRIVHLSHVPLGASCASGDADAVSKIPFHILQITCTLSLFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5H3</accession>
    <name>A0A0N4U5H3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6458</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5H3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5H3"/>
    <dbReference type="WBParaSite" id="DME_0000209801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000209801-mRNA-1"/>
        <property type="gene ID" value="DME_0000209801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232659" evidence="1">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="62"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000209801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22857" checksum="CC49F27787897700" modified="2015-12-09" version="1">MKYSILIPFLFLLTVDFGEFDGATLKKKLGISGKKSYKAPSRKNPATKSKVTQCSGSKITMQERSQILFWHNEYRSQLAAGKVRTDTNYMPRGSDIRKLRWDCELEKTAQWWADRCQWKHSTPSERNNKGENLYKYMQNIVINRTGHMKNAAKNWWDEVKLMAKPTTIFTTKLVDSVKPKMIGHFTQILAISQWCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5I0</accession>
    <name>A0A0N4U5I0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6466</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5I0"/>
    <dbReference type="STRING" id="318479.A0A0N4U5I0"/>
    <dbReference type="WBParaSite" id="DME_0000210601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000210601-mRNA-1"/>
        <property type="gene ID" value="DME_0000210601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000210601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24097" checksum="3E3F845C893F8E4D" modified="2015-12-09" version="1">MAEIDVSRLPSSVRERLAQLDLELSEDSKMTASPSTRAQRRHQRRLTREESRFHSEIRAEAVQQALSEYSKGKKERPNILQPIKRRGIEIRRDRTKNRLSESSSDEDSMFGSSDRSKGTPSSQSLSDRNKKISDVSRDSKNISRAPPPDVTSNAVVAEAVVRRNEKKQQKYKSSEQYEQRVWSRPSKESDQTDSPNIAGSTESTSLASDAMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5P9</accession>
    <name>A0A0N4U5P9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6547</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5P9"/>
    <dbReference type="STRING" id="318479.A0A0N4U5P9"/>
    <dbReference type="WBParaSite" id="DME_0000218701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000218701-mRNA-1"/>
        <property type="gene ID" value="DME_0000218701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000218701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32275" checksum="3FDAFC4E33FC1B48" modified="2015-12-09" version="1">MSSKRLISSRQCLSYKKYMSDKRSDIDPVVIVHGLFGQKRNWQSIAKALLRELNTDIYAVDLRNHGDSFWRETMEFDEMSDDLKEFLDMENLKKIHLIGHSLGGKISMKFSVNYKFLLKSLIVVDISPKKYDNEDLLNLINIMRTHVNLNETIDKIDKNLKSFIDNEDLRKFILTNLQRLPNGNLKWKLNLNIILKELNKLVDNVLNNDNEIFMGKTLFIIGAKSNYVDKNEFCDIKKIFPNSEFSIIENSGHWVHHDQPQSFIRVVAEFIRSTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U652</accession>
    <name>A0A0N4U652_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS6738</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U652"/>
    <dbReference type="STRING" id="318479.A0A0N4U652"/>
    <dbReference type="WBParaSite" id="DME_0000237801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000237801-mRNA-1"/>
        <property type="gene ID" value="DME_0000237801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000174">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="186"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000237801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51024" checksum="3F997F1EF60A0B8B" modified="2015-12-09" version="1">MMPQWYDYKLAWDPEKWNNIRKLHIPSDQIWIPDILLYNNADGEPHITVTSDALVYYTGAVIWKPPSIYKSFCPIDIEYFPYDKQSCSMKFGGWSYNGFLLDVRQLPSRPTDVIETREDEKGKEYQFLEVGMDLSSYYPSLEWDLMSVTSMRHEQLYPGCCGQEFYIDISFDISLRRKTLFYTVNLVIPCMLIAILTTFVFYIPACEHKVTFSISILVTLTVFYLVLIELIPPTSLVIPLIGKYLLFTMFLVSASILLSVLTVNYYRRSGTTHPMPYWMRQVFLRTLPKYLFIKPPDEDLPSEDGSSFSGSRAPESRRASPYFLSIAQTVDGEIRLSQLAQLRGMHPDLIRRMIDNVSFISDHFRAMKKEDRISEDWSYIAMVLDRMMLILFSAVNFFGTLLILLQSPALYDNRLPMTILPASKPLSGDTFESLVNSSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6R1</accession>
    <name>A0A0N4U6R1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6987</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6R1"/>
    <dbReference type="STRING" id="318479.A0A0N4U6R1"/>
    <dbReference type="WBParaSite" id="DME_0000262701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000262701-mRNA-1"/>
        <property type="gene ID" value="DME_0000262701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9993594at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF4">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="260"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000262701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46602" checksum="7F1307E30F172B5E" modified="2015-12-09" version="1">MVAPLKPSKGLLERRGSSASLTINLGISDNSIIDLSPIQENLAIDDSGSRKSRFLTRHQLKNLNIIDSLPEIFAEFAMLPNPNISCCTRIAGCSQKNRHQVWPIGKTRVRIWDNNSSVCSQDTPRSTNSLIDDARNYINANYITDDNLVSSYIATEGPMPNTINDFWAMIWQEKSIAIVMMTKLEEQTSNDGQPKSKCEKYWPEEKHRYGAITVEVENVDIDCGIIVHELLITRGDEEHRLRHYWFTEWNDHRLPIGQISKILKLILDLHSYRAECRKKFTPLGPITVHCSAGIGRTCTFIAMLLGIEQLNTIQDGIDIYAIVSKLRMERYGAVPRPEQYVFIYLALQQMECLLREPELIKKRLIAADEASPYLKLLISDFREDEILDEENVVDTTVHISSNWLNVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7H7</accession>
    <name>A0A0N4U7H7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDSL esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS169</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7H7"/>
    <dbReference type="WBParaSite" id="DME_0000294001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000294001-mRNA-1"/>
        <property type="gene ID" value="DME_0000294001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000294001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18199" checksum="5BD6737C3AB0D652" modified="2015-12-09" version="1">MIVQRPPNFCTLKSCRVEPVTIASGPMNPHNDTTQNDTILAEIIKINRLNKLSKFPAIPGLKMIDDLPTLYKLKRIGVTNANGSGNITVVILGNSLALSALHYIVPAFGLHRIRHIKLLSASGCIPIYNVEAPKNRHPKCPEFSKVAMEIIQKMMPDVIFLNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7M4</accession>
    <name>A0A0N4U7M4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7153</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7M4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7M4"/>
    <dbReference type="WBParaSite" id="DME_0000299401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000299401-mRNA-1"/>
        <property type="gene ID" value="DME_0000299401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6363818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF530">
        <property type="entry name" value="MSTPROX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000299401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27311" checksum="4F46E7E45F4F00F1" modified="2015-12-09" version="1">MECLGELFECISDTLTVVYEILENLSFLNLFLPQSINSNSLRELTLEGKSLHIGSNVFTGLKQIDFFNIRGASMIFSDAFENVSRIHSASISLSSNEIQRIGNEAFSGLYTVARLVIHENTIENISNYAFSSIINIGELIIKNNIIINIGEESFSSPAWRTKISDNKFYCSCNIYWIKNIKVCLLAIFKDVFILRRNYCGAEEGHRTLINYSPICNKAPRNINGAKAFCKYLIFLFLMIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8R9</accession>
    <name>A0A0N4U8R9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SGNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS321</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8R9"/>
    <dbReference type="WBParaSite" id="DME_0000345501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000345501-mRNA-1"/>
        <property type="gene ID" value="DME_0000345501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000345501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34826" checksum="70A28869BF56048D" modified="2015-12-09" version="1">MQQTTKLGASLIILLIVNGIRLYQYVTEPHTVSSVSNDIKTKLSSRAIEQNAIIMGFNTDLPKFRSFIPIKANVKHDLGGYYQGDGSITIALIGNSYARSIMYVLKLILGKSFNKIRAFSNFYCNMTLHADDMDCNDYVRNMILELNELRPDIIFIEIVNADVLQTLIDMLITITKRIIIEYPIANRKYGTFNITSRIMRSLIKHEPLESMDIEYLDYYSYYKYAISIFDSVRCYKCDRIYLYKLFCNSKICRTYDRKTLTSYFDANIHLHRYTLNALQNFYRKVLNELYAKGYISHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Y1</accession>
    <name>A0A0N4U8Y1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger CCCH domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7526</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Y1"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Y1"/>
    <dbReference type="WBParaSite" id="DME_0000352101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000352101-mRNA-1"/>
        <property type="gene ID" value="DME_0000352101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000352101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62344" checksum="1FD929E3600BFE07" modified="2015-12-09" version="1">MDRIVASCELLFPHKKHSDTNDKCLRLMPPPPPPPLMLSPPLPLSPLSSPSSLSYPVTHNLSTSPSSAKFRIDTVHCTNNNDFRPADYQSQIGTNYSRDPIRSSELEAWVLTSDHFVKYSCDKKRNSTADKQSFIHWLNPPPPPPNFDPFCATQSKLSTSHSSDIKLTFCNTKSQFDEYEECQGSRNCSQPSGEAADFVLNKKIKVESEEDMPMELADEMHTTRSKFQGKICADIIFDSRPQMSVSRTFPLKNYFGKKYPFGNNKRTCHSANSAAVSFANISPQAPLIVRTATKLIRKSKFTSNLQRNSNPTANANDVLRQITEQRNVLVSLKKIVNNGTLSRNGMCWRRRRSSDPVNCDKTIYISEMASDETYKKKNLYLRRINSKIYTDDSDECFDFAERGECTAGSLCIYRHHGKIDHQEKKFCSRFLNGLCRDSRCRYSHDLADHQIPICDYYLRMVCSDVNCKFLHVKYAAGVKPCRFFNRGLCKRGIECICPHRYYYSVIQSKSVPVDNISEKRFFRYESEPSHEENECNTELLTWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U979</accession>
    <name>A0A0N4U979_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7633</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U979"/>
    <dbReference type="STRING" id="318479.A0A0N4U979"/>
    <dbReference type="WBParaSite" id="DME_0000362801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000362801-mRNA-1"/>
        <property type="gene ID" value="DME_0000362801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000362801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9595" checksum="2FA60B8007537D2D" modified="2015-12-09" version="1">MSRPKKGDSTADQIKIATQLRGTIMPIKKRARAEKARAITDGERKFEVFRYLRRVRADKRLKGAREKKAREIVEENVTVGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9H1</accession>
    <name>A0A0N4U9H1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7744</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9H1"/>
    <dbReference type="WBParaSite" id="DME_0000373901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000373901-mRNA-1"/>
        <property type="gene ID" value="DME_0000373901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000373901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25608" checksum="4278529F44AFD28D" modified="2015-12-09" version="1">MIANTTIKYEIIIVNGFAIYDNFDCNDHVLVPAVSPTLEEPIFVMNEGKAKEQSQKKWKKEEEIMITYVEDGTSNLPFVLQDKHGKSLEETSSLKKEESESITISPLKIDSTAITINSFEKKNTILPKKDDVKIRPKSSSPIKIIALNAGPSKHRATIQKFPTEPKNDFQSVDEPKMQPPSKPITFLKNSKGIYGGVVGAYNHEAIGWRPWAKSSNTFSNYQTFLNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9L6</accession>
    <name>A0A0N4U9L6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7793</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9L6"/>
    <dbReference type="WBParaSite" id="DME_0000378801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378801-mRNA-1"/>
        <property type="gene ID" value="DME_0000378801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858459at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041119548" evidence="1">
        <location>
            <begin position="21"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="60336" checksum="B5F3D7C7A680DFF1" modified="2015-12-09" version="1">MKFTLLLDLVGSLFPYLINSCSPQYRKELHYLDFYLGIRPFNDGHFEVEEALTNRYITNASDLGCNFTSSCHWKNADSDGLLDTSDFYRFYKSDYKSYPIQIAPGNSTPALGSTFAFAGNTTKNGQSALLISSPVVLLRPPMICGFIQPRNSLCDINMPEIEVPFRIGIRAYNLRDPSVGSLVMIGNINYMADICLEPKLSSIFGRTAVPPIFYLPLPQSGSEYSCIDYRSNCLWANSLSSISEWKIGRNIKHWNEYIKSKTMPNGTFFYQYVDSTFDKPYSQLRSELIPCTKSISSLSFRYWMNEGTQVQVCSINERNIVISCAYLNEENSPGPIIIDVDAPADEPFRVTAGLIFFSVPKCFTILELIQFQKIFAGNVALAILNNKNRVLLVSPLTPCAIDSTIKTVYYSQNAILKICVKEKCIRSNIDDSGSIFFQFNSKILSVQVHQKTFGSEVYICDSDSDSPHDDSCHLLLGPIIKKNKIKKSIYNLDYFKNQFSLVFFNDKFEQFGDAEFEIFSIDIFDEFNQKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9N1</accession>
    <name>A0A0N4U9N1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zf-3CxxC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7810</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9N1"/>
    <dbReference type="STRING" id="318479.A0A0N4U9N1"/>
    <dbReference type="WBParaSite" id="DME_0000380501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000380501-mRNA-1"/>
        <property type="gene ID" value="DME_0000380501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="201"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000380501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30694" checksum="A41E5E2D36E324EA" modified="2015-12-09" version="1">MFEYDRLALDVAEQVAQIRSTVIASSPKQILDNLSVIWFFLFSRGKYVGNGFSFSGPDGFDCGASSGYGSPGSGTTPLSSPAPHMLLLPTHVQRALCDYGFFDEAENIASLGPTLIDMEPNKFKSPSSENDENIPSQAAQEDGFSHDEIAQFTQLLCSPKKAPPSKYQCHICYRTGHYISDCPMRFNSPYEELTPYQGRKKCYGEFQCQQCKRKWTSQNSVANEAQSCIKCHIPVFPHKQLPVDKAVAMGLVKAQRVVPSKLAPIGHGRPPFNTNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA02</accession>
    <name>A0A0N4UA02_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7953</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA02"/>
    <dbReference type="WBParaSite" id="DME_0000394801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000394801-mRNA-1"/>
        <property type="gene ID" value="DME_0000394801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841793at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000394801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8061" checksum="7A3E08AFD88BBC3D" modified="2015-12-09" version="1">MSNGKESRALESLTESQFGIDDSEVLDGLSKEDIEEETLCFQLCQLDPLYPAYFKHMNTGRMKVNLFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAA7</accession>
    <name>A0A0N4UAA7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS433</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAA7"/>
    <dbReference type="WBParaSite" id="DME_0000406901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000406901-mRNA-1"/>
        <property type="gene ID" value="DME_0000406901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000406901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9344" checksum="7094C2CD35D81403" modified="2015-12-09" version="1">MLFDVFHRELHVCKRYLPVLITIAAIVFRKLRLLRESTFLSVRVHLSIIAAAVVACRLSHSAARPYVLRTHLAFLQSGTCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB70</accession>
    <name>A0A0N4UB70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Four and a half LIM domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8316</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB70"/>
    <dbReference type="STRING" id="318479.A0A0N4UB70"/>
    <dbReference type="WBParaSite" id="DME_0000443301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000443301-mRNA-1"/>
        <property type="gene ID" value="DME_0000443301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09346">
        <property type="entry name" value="LIM3_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09432">
        <property type="entry name" value="LIM6_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000070">
        <property type="entry name" value="Four and a half LIM domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000443301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19722" checksum="23C40AB344CC471A" modified="2016-06-08" version="2">MKKMEYKGKQWHDKCFCCALCRTPIGTRSFIPKNEEVYCASCYEEKFATRCCKCKKVITTGGVTYKNEPWHRECFCCTNCDTSLAGQRFTSKDEKPYCANCYGELFAKRCNACEKPITGIGGAKFISFEDRHWHNECFVCAQCRTSLVGKGFITDGTDILCPECAKARLMAAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBD8</accession>
    <name>A0A0N4UBD8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8396</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBD8"/>
    <dbReference type="WBParaSite" id="DME_0000451301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000451301-mRNA-1"/>
        <property type="gene ID" value="DME_0000451301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841709at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000451301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="33003" checksum="68A100090E5F532E" modified="2016-06-08" version="2">MVSVLFKVLVEHVLSIRVKLNITSEYFRIYEGFIVSDEKTSEIIIDKLINFLRNYMPSLQELSFRHAPCTFTLSNLIQLATVVPNLKKLDISRLGNWPFFEKGAVLALPYFRKLTSLRMDAFQTNIWPGKGCAYRMEILPIRELYNLETFEIECEFDTLTKILHKMHEAQFVLFRLKRISFGVKRCSANFSELLIWFLNSHRSLRFVRICNALFTTSDQLRRFYSCLILLPFLCELRLDNCTSCDRIDSNMQTQFRRALTNKGVVQLGTVRSMRFDPNSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ7</accession>
    <name>A0A0N4UBQ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8537</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UBQ7"/>
    <dbReference type="WBParaSite" id="DME_0000465401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465401-mRNA-1"/>
        <property type="gene ID" value="DME_0000465401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="280"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="577" mass="65176" checksum="22105CF4DB30252C" modified="2015-12-09" version="1">MSEKELELYKLYRPEREVPKIRGTDLLKDPRLNKGMAFGLKERQYLGLHGLLPPAFMTEEQQLYRVISKLRAQPNDLARYVQLDGLQDRNEKLFYRVICEHVKELMPIVYTPTVGLACQNFGYIYRKPKGIYVTINDDSISKIHHILSNWPENDVRAIVVTDGERILGLGDLGAYGIGIPVGKLALYVALGGVQPKWCLPVLLDVGTNNEKLLNDPFYIGLRRQRVRGEAYVKFVDNFMKAVTKKFGQNTLVQFEDFANVNAYPFLDRYRNKYTVFNDDIQGTAAVCLAGLLSSVRSVNRLLSQEKIVFLGAGAASTGIADLIVMQMESEGLSKEEARSRIFLMDSKGLITKTRSEPIKEMHNRFAKNIPPTKSLLEVIKTVRPTAIIGASTIKGAFTEEIIRTMAKINERPIIFSLSNPTNKSECTAEEAYRFTDGRVLFASGSPFPNVELNGKIFKPGQGNNSYIFPGVALGIILFKKVASCVSDHDYSVGRIFPHLKRVREISIQIAVEMAKYCYKNGTADLYPQPEDLEQFVRAQIYSTSYDEMINVTYDWPTNDMKHGFPVPPRNYDSAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBY9</accession>
    <name>A0A0N4UBY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8633</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBY9"/>
    <dbReference type="WBParaSite" id="DME_0000475001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000475001-mRNA-1"/>
        <property type="gene ID" value="DME_0000475001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000475001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30877" checksum="901E69FA9B32630F" modified="2015-12-09" version="1">MHEGNRFKTLRHLCKCRRDLVAIATANHIRDTRCNGFGRFAIAFECRQSMKTMSAPIATSTANEATASMVGIIASEEVNDDKNVNNTTGDTMNGEETSSQAEESTQKPWATPRQEPVNGIVQPPVIPPVGKPTRHTNQLDFMLKEVLKPAMRHKHAWPFLKPVNAVQLKLPRMIVHGPNYELIYFFLNFQNFNLDNKERAVHFSSELQIPQDYHKVIKRPMDMHTIENRLKNRYYCSAKDCMELSGYLSTAMFCGSSLNANVLIQLSSALMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCI0</accession>
    <name>A0A0N4UCI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8775</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCI0"/>
    <dbReference type="WBParaSite" id="DME_0000497601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000497601-mRNA-1"/>
        <property type="gene ID" value="DME_0000497601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF5">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229851" evidence="1">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000497601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27951" checksum="EF8C00BCF185A22A" modified="2015-12-09" version="1">MIIFLIVFSTQGNLAFDSINNQTIFDCNRVPISFCCTTRMQHECTSKCAFIECTPDFYKRSTKNEKYTRAPTMNRKIRNKFFLPPPPSTDTEALVDIESKDYDLESITSSDSDYRCDNFNSAKCGTAPYFTPCVPSFIADNRMRDCCRQKNLPLGCQNLCRYSVTVPEIKLAMDKALCGILHVAPIIECASAGHDNTQCCRYKGIAQKSGPQCEVFCRSGNGLYALGIQHLVCNKVMGELISCHHAGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCN2</accession>
    <name>A0A0N4UCN2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8832</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCN2"/>
    <dbReference type="STRING" id="318479.A0A0N4UCN2"/>
    <dbReference type="WBParaSite" id="DME_0000503301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000503301-mRNA-1"/>
        <property type="gene ID" value="DME_0000503301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="3">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000503301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15723" checksum="26595E626761B0E5" modified="2015-12-09" version="1">MIFEQWLYSELGESTFPSLHLPPFADRIKLTQPFPLQVNWAIDIHISKYSQYRSLNPIFNDNSGFNNEYDEDNMENLMENKHRSLLLEVTDGQRKLKGLEFGDIKDFNVKWPPGFKAIFISQFLNSFIRNSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDJ1</accession>
    <name>A0A0N4UDJ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UDJ1"/>
    <dbReference type="WBParaSite" id="DME_0000540601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000540601-mRNA-1"/>
        <property type="gene ID" value="DME_0000540601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70763at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020338">
        <property type="entry name" value="SMN_gemin7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11095">
        <property type="entry name" value="Gemin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000540601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15527" checksum="CA11A1D373F80ECF" modified="2015-12-09" version="1">MMGVVGECAFDEDTIEQKQATELRERYLRTMAYFAGKEIWKEIPVEDSIPGFSQSPFPLVTHITKVNDAEVELKLYENTKTDGKFVTLKPDNSHYLIDSLKTPIGVVKCAAVRMTDTLMITANLCESFAVPKDLFSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDL8</accession>
    <name>A0A0N4UDL8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">YEATS domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9232</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDL8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDL8"/>
    <dbReference type="WBParaSite" id="DME_0000543301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000543301-mRNA-1"/>
        <property type="gene ID" value="DME_0000543301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16909">
        <property type="entry name" value="YEATS_GAS41_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000543301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27435" checksum="7F7829E07AE973CC" modified="2015-12-09" version="1">MERCKAKRIVKPIVYGNTASLLLKKREEDNHTHEWTVFVKPYYVEDLSKFIRKVQFKLHESYSNPSRIVERPPFEITETGWGEFEVQIRIFFVDVNEKPLTAFHYLRLFQPQVTLTNGKTIVAAEYYDEIIFQEPTVFMYKALTSVEGRKYDQKRFHTDFIHVRKRTLDMINNARAEIGKEVDDLRDSLRAAHNLIEKYRKEVENLETMVNNSDSNQFSLGNGQDTDTNGTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDV7</accession>
    <name>A0A0N4UDV7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9274</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDV7"/>
    <dbReference type="WBParaSite" id="DME_0000553301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000553301-mRNA-1"/>
        <property type="gene ID" value="DME_0000553301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854748at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35180">
        <property type="entry name" value="PROTEIN CBG06219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35180:SF4">
        <property type="entry name" value="PROTEIN CBG06219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000553301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23832" checksum="48D726FB5C887D85" modified="2015-12-09" version="1">MCDEEVSLKPQKLFLNKISGMTAKAVSDITAYRPLPSNGGCMWFGTAPFCNHHCPPEYDYIRSSNGRCSSKWFASVCKPDPSFGYPCSTVLGNYFTKRFCCKIKSRIRIVATILIFIYRSDPTQCAWSGRWMSANTAHNVYCRYDNNFGKCGSLDCAVNHYDYQAHNSTEIFGSKCDQINLFGYNGKATCGYISWFDKNGQIVDSWYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDY9</accession>
    <name>A0A0N4UDY9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9308</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDY9"/>
    <dbReference type="STRING" id="318479.A0A0N4UDY9"/>
    <dbReference type="WBParaSite" id="DME_0000556701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556701-mRNA-1"/>
        <property type="gene ID" value="DME_0000556701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49433" checksum="E1CD4C70BB81480E" modified="2015-12-09" version="1">MITPIFSIKQDDDFLFIDIDARYANIKETEIEYFDKIFFFSSSPYFLRLHFPCEIIDNEKGEANYDSENGKFLIKVPKKFHGEFFPNLEMITELLKPSKIEADHLVQECGEENINDNEYYMEQTIEQKELSPIDEVCKKFGYGFGWRRHNVLGKLIHEIGNLIDLKNPESVLIEERSSKCLQQDQISFRPEHYLADLYEKSDILDECLNFQLPEICFELSSKDREKLKELGRRKIAILSDACNHSVILSLIDILFAYLYDLRTTDGEHNVESGWTIIKLSPTLTYLTRWKNAKEAITSAIRRALCYPLYRHWQLSLKVFDDIKRVISRGKVAILHCLCEIHYILAISGDFRYILNDLYLTDYCVWIQSVSDEKFVQLFDDLKAIKIEKRDVQLELCTLEIEAQISTLEIKENIEEMDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE00</accession>
    <name>A0A0N4UE00_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS624</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE00"/>
    <dbReference type="WBParaSite" id="DME_0000557901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000557901-mRNA-1"/>
        <property type="gene ID" value="DME_0000557901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000557901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8226" checksum="833F17DD79D26972" modified="2015-12-09" version="1">MSQSYPNIQYYETVADIKLYEFTWNCVEVHTRIITLRTRMMKRKHVSRVRMRSRRNSCTYYVRGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEJ0</accession>
    <name>A0A0N4UEJ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like protein NEDD8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Neddylin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS791</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEJ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UEJ0"/>
    <dbReference type="WBParaSite" id="DME_0000579701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000579701-mRNA-1"/>
        <property type="gene ID" value="DME_0000579701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000579701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9211" checksum="F3AD94230DC2D8BF" modified="2015-12-09" version="1">MLIKVKTLTGKEIELDIEPNDKVERIKEKVEEKEGIPPPQQRLIFAGKQMSEEKTAQDYRVNIVSNFNLIHLYIALKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEW1</accession>
    <name>A0A0N4UEW1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS877</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEW1"/>
    <dbReference type="STRING" id="318479.A0A0N4UEW1"/>
    <dbReference type="WBParaSite" id="DME_0000593801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000593801-mRNA-1"/>
        <property type="gene ID" value="DME_0000593801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000593801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="629" mass="72549" checksum="2F9FE9AD74F02BFD" modified="2015-12-09" version="1">MPASPLTIEVQSSQHLDLRNTVGNIPFHWYDDCEHFGYDIDGNPIKRVEKKDEIDSFLEKMEDPDYWRKVYDRQTGSYIVLTDEQVEKLVAIQQSRYPVVGYNPYQPFLDIFSSNIEIHPISNQPASKASFIPSRSEQLLVGRMVHAIKMGWIKPRRPKKDVYDLWANEVSDKKSKSEKARLRMHFPAPKVALPFHSESYNPPPEYLFDDDELKKWEENEPDERRINYIPQKYSSLRLVPAYEQFFNERYERCLDLYLAPRQQKMKLSVDPSQLLPELRNIADLRPFPTTLAFYMRGHKGQIRGLSMEPKFGELLASAGEDGTIRLWSVGVGRCLKVHNMNGVVNCVAIYPSDKYTLLAAVVQPCKVVIMNYECGDKHHIGITSQFISKLVIDSQSEQNVRWSIDDKNRIILSLPEETKQVVWHEKCDYFATHSLSKSANSIYIHQLSKCLSQKPFSRLKGFVTSICFHPKKPHFFVATKKYVRIYDLAGHRLIKKIITGTDWLSCMRIDSSGDNLFIGGLDRRFSWIDLQLSNKPWKNIRHHTAAIRDIAAHHRYPLLTTVSDDSTAIVYYAKISVDPLKENEFLPVRKLHVHNVKNNGLSILCAIFHPSQPWLITAGADGLIALFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFK9</accession>
    <name>A0A0N4UFK9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1127</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFK9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFK9"/>
    <dbReference type="WBParaSite" id="DME_0000623001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000623001-mRNA-1"/>
        <property type="gene ID" value="DME_0000623001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13761">
        <property type="entry name" value="TGF_beta_BMP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF119">
        <property type="entry name" value="TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="249"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000623001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40291" checksum="2D07FF1A5F5458D9" modified="2015-12-09" version="1">MMVGCFEKATGFEGVIVRKGTDAILVCGESTAVRNVSRCVDFGGMEGKLNSRLESKILELLGIDHIKPHYGVVKDDLASRFMAELYENLEQDVHLNPAYKYLVSKPFLSTEEKKAIELGKADTIVSFLPREVSTKDSMSVVRFDMNNTLFGPLLYSEFRISFNGSTKPSYVKAFPSNSKRKSPIQAYLANNGHFVLNITELLRRWVTGSSKIPILTIIAYSADGHKYPLDAFGLWQSFGVASFAEGTNIRKRLKRKRAVNDDLVTVDGFSNGFSDWVIAPDGYHAYYCDGYCSFPLNNRMNATNHAIVQTLVHLIDPSRTSEAKCAPSSLRSMKILFIDNAQNVVLKRYKDMQVRDCGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFL0</accession>
    <name>A0A0N4UFL0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1129</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFL0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFL0"/>
    <dbReference type="WBParaSite" id="DME_0000623201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000623201-mRNA-1"/>
        <property type="gene ID" value="DME_0000623201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="106"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000623201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38261" checksum="E4CD97716BFAD789" modified="2015-12-09" version="1">MAEKQKQKTGKEKIAESSVIQLDSEEMGPYTVVDKLEQSGISASDIRKLKEAGFNTFESIAYAPRKELVAIKGISEQKADKIFLEAAKLVPMGFTTASEVHVKRSEIIQIETGSRELNRLLGGGIETGSITEVFGEFRTGKSQLCHTLAVMCQLPVDMGGAEGKCLWIDTEGTFRPERLLAVAERYKLSGQDVLDNVAYARCYNTDHQMNLLLQASAMMAESRYALLVVDSATALFRTDYSGRGELAARQMLLGKFMRALLKLADEFGVAVVITNQVVAQVDSACGMFQNDSKKPIGGNIIAHASTTRLYLRKRKGETRICKIYDSPCLPENEAIFAITTHGIDDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFP8</accession>
    <name>A0A0N4UFP8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1172</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFP8"/>
    <dbReference type="WBParaSite" id="DME_0000627501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000627501-mRNA-1"/>
        <property type="gene ID" value="DME_0000627501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000627501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="9255" checksum="7FF02E8A2857F177" modified="2015-12-09" version="1">MLMPVKTMRQMRHLISKRNATNLPIYAKKTQMKDEWRLLKRKRKRLRQLRDEIRELSNQLHSKRVFYKGIYLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG35</accession>
    <name>A0A0N4UG35_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9543</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG35"/>
    <dbReference type="STRING" id="318479.A0A0N4UG35"/>
    <dbReference type="WBParaSite" id="DME_0000643201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000643201-mRNA-1"/>
        <property type="gene ID" value="DME_0000643201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5989925at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000643201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52958" checksum="BFCEF62CD07BE19D" modified="2015-12-09" version="1">MLIRYLRQSSSLLFCQNEFSASIRGKLFQYNRFYSSLNDSDNKNNDENGSINLSKQGNVKEGETENESTDASAADDNLSDSLDKGELLFRKKGEKGRKKKSLKTVDIIGEEMLNAVSDISKTLHKDDVTSRKKTTYDLIAKLTEYEREKYESATAGQIEEMLAAPNIQKLFDSQQASEEKTIPKFLDSRRLKRGLFALRREMFYQAKQNGYNAKAAQDIAERAVEKARERVLSRLEKATEQKLLEKERTELKESEINEKEHKFFDLAFQVADKILYPQMRSELEKEKSKEEQPIIEPDLNMPNIFAADQPSLNVFTDISALKEHSLHYWSEWDLNAARIWNQSLGPRNGFEEMIELTEKGKMWPYPIDNEYLLGDEENVTFHEHIFLEKVIAPYNLPKQGPIAHFMELVCVGLSKNPYLTAKKKREHLDWYLLISLFILSHTFILNNIYIIISIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG96</accession>
    <name>A0A0N4UG96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9612</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG96"/>
    <dbReference type="STRING" id="318479.A0A0N4UG96"/>
    <dbReference type="WBParaSite" id="DME_0000650101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000650101-mRNA-1"/>
        <property type="gene ID" value="DME_0000650101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF116">
        <property type="entry name" value="HYDROLASE PNKD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000650101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20281" checksum="61E82D577A3DFD8C" modified="2015-12-09" version="1">MFRDHCYGNKSMKRLYPDLIICGSKLDRPFKVNRFVEHEELIMLDDLCFQALSTPGHTNGHFIYRLITKDNVDCLFTGDFVFTAGIGRIFERNEQKMLESIFSLKKFSPSTLLFPGHEYALLNLSFAYSLDRNNSILNNMMQVVREQRRQQLPLVEQFNNLFEIGVFDSHWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGA3</accession>
    <name>A0A0N4UGA3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AIP3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9621</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGA3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGA3"/>
    <dbReference type="WBParaSite" id="DME_0000651001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000651001-mRNA-1"/>
        <property type="gene ID" value="DME_0000651001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022652at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000651001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="57372" checksum="E69A40BB8047983E" modified="2015-12-09" version="1">MEFRHSIIGFRSPMVQRYDGYYDHYSSDTSSQDARSGSITPIVDKEARFRMETMERQLAGLSSLVHSALVSKGMSESSQRDMQELRRQIFALHPDVSSSSVLSTTDPSLPDSSSVNGETQRQLINLKRQANEIHNQLKQIRRNFEMSSQDAQNVLHNAFEKIQKHLINHMKILETSKYENFLKNERTDHITNINALQKSIQLFEEDVEDIRKLVLNTNRKLKITEVEAFTQSLTKIGRNAARLKTQFPELQRQIEANIKRNMEKVVEEERFLKEEPKQIDHCLHRCKALANMMVTMKKLAMLQDPDINNTYKYELNKTGSSTKTENGSPTGYPVIDPLTNRINERDEISVVSSGRTENLPVEFQREIEGPDQPPPVPPSPTNYNVPSTSEKGEPHVLDTILDELTNTMTRDQKAKSPNAMTKAAPPKPPERFSTPDARNRFTRSQIEEMQRRVMHSVSPIQGLAVQATYFANGRTPKEALVHSQSAPSTYSRQTNENNNTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGC1</accession>
    <name>A0A0N4UGC1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9643</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGC1"/>
    <dbReference type="WBParaSite" id="DME_0000653201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000653201-mRNA-1"/>
        <property type="gene ID" value="DME_0000653201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000653201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14323" checksum="D244AF51B799CCE3" modified="2015-12-09" version="1">MPRFMLCTMVDKVIHGDGSIYDAKGKIAELKLDKECFEEMVSVTGTKRFYHRWTTNRHAEKRWKHGKNASKAFVSKDSECGSIVQIDFGFVQSRQADVFSMLPNFSCQARNGAINIALRQGMVQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGG2</accession>
    <name>A0A0N4UGG2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Telomere length and silencing protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGG2"/>
    <dbReference type="STRING" id="318479.A0A0N4UGG2"/>
    <dbReference type="WBParaSite" id="DME_0000658101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000658101-mRNA-1"/>
        <property type="gene ID" value="DME_0000658101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000658101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27125" checksum="B902E596B579ECC6" modified="2015-12-09" version="1">MKRSYLFRKPIDVNNDDDEFLNIRESNRKIIHAKPIKEKYVKKLGSLGSGIQLIEEKSEECRSLSFDERNKLSAKILKAELKGDLDLVKKLKAKLEGSSAENLLQSEKSEILLRTNEKSGLTMPVFKKAKCDDTDHSSEKTKYKLGDVEAKYHSQMELNEMRKEEKYTNASDQLYLFSQSAKAACSSRTEDDWVIDDAMMSQKKKRKFAEKEQKREHEKAIRGRHGKLCAVFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGP3</accession>
    <name>A0A0N4UGP3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGP3"/>
    <dbReference type="WBParaSite" id="DME_0000667401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000667401-mRNA-1"/>
        <property type="gene ID" value="DME_0000667401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000667401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8481" checksum="1909511DC16A38A6" modified="2015-12-09" version="1">MILSRKKASARLLEYRKYRYGNPHGVRGEYSRAECSTPDDTDFFCACFNYVTILLPEPRSFIFSPERGFLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGT7</accession>
    <name>A0A0N4UGT7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1337</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGT7"/>
    <dbReference type="WBParaSite" id="DME_0000672301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000672301-mRNA-1"/>
        <property type="gene ID" value="DME_0000672301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000672301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5592" checksum="8AE83CD06FA146B4" modified="2015-12-09" version="1">MMKRTSKTKKERDDVQDNQESRWASQLRLGKRRRWASQVRFGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHI3</accession>
    <name>A0A0N4UHI3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1568</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHI3"/>
    <dbReference type="WBParaSite" id="DME_0000701601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000701601-mRNA-1"/>
        <property type="gene ID" value="DME_0000701601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925875at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="34"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000701601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17366" checksum="9A031DDE23078A1E" modified="2015-12-09" version="1">MGQLYGCDIYRITNVNFVPLKRPSEFIDPRIIELQQLASSGIFYFASSSNMNQLFDLTLSSQKRACGEFGDTSYFWNRNLHLPLQRYGIEPSEWFLRVICGSIQIRTVYIGCKIAKVAVISRLSCNRVGTRFNVRGINDDGHVANFIETEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHM4</accession>
    <name>A0A0N4UHM4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9821</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001192">
        <property type="protein sequence ID" value="VDN59848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHM4"/>
    <dbReference type="STRING" id="318479.A0A0N4UHM4"/>
    <dbReference type="WBParaSite" id="DME_0000706001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000706001-mRNA-1"/>
        <property type="gene ID" value="DME_0000706001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000706001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52171" checksum="88D9D315D6FA76FA" modified="2015-12-09" version="1">MPVDSEQLGISIIGERPCLLKIVKNSTANKVGIQDNAILIAINGKNVENLSHIDVIEILTNLGSKADTLAITFRKNKLLISTPMKMNDSVQLNGFCSSNSSSKFFKMVLQIVKHNNNEKSTKLIDQQMIQKHLFYQCFLTFIGRISLKCNNHPSLLINEAIEKLKKNEPFTVQTVLLQIYFDIILVTNSKKSIILQFAASDIQYAVVSPENQQYLGIFLKTNYSDEISCSLFAIDEQLLFHCFHEKYTKRHGLKCSVVNVNFSSPFNACDKFPHSAVTVLRHMRRMKPPIMVFAQNLRAFTKIREPQMNDASGSSSADDPPLSMKVNNSSTRFSMKDLFKHSQSYSIQSDSEIGEVPKKIEQSEFQNYIGVHKKYEENQAKQTYDSNNYEINDSEKVINNDRSQGINFKSSFDEICASVKEKHPEFDAYFCLLNFTKNELKKEVILIPRRSLAKVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIM3</accession>
    <name>A0A0N4UIM3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gelsolin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1751</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIM3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIM3"/>
    <dbReference type="WBParaSite" id="DME_0000745801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000745801-mRNA-1"/>
        <property type="gene ID" value="DME_0000745801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000043">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="270"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="369"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000745801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54194" checksum="E19518862CC2B738" modified="2015-12-09" version="1">MANIDSELKDIGKKRGLEIWRINKFKLERLPEEQFGNFYSGDSYIVLYTKNPGEWNVHFWLGSETSTDERGAAAIKTVELDQALGGLPTQYKEVEGHESSLFLSYFKEGIKYLKGGVSSGFKHVKENKYEDWKPRLFHCKGKRNVRCVQVDCNFNSLNLGDVFILDCGLDLYVWIPPESGRLERIKGMSQAKNIRDNERTGKPRIHVLDQDWDTNTDFWRIIGGDKKKIKSAELGGVDENYWRSSRDTISLWRVSDASGKMEVNIVADGTFQYSQLDSKDAFILDAGHGGVFVWIGKDCTIDERKRAMQWANSYLQKMNKPEWTQVTRVLEGSEPAIFTQWASSWEGAKTKQIFQPKLFQCSDESGNLVVEEISNFTQEDLDGDDVMILDGLSIIYVWVGTKANVNEKKHAESTAKKYLETDNIPRHKTVIETIYQGSETPAFKKFFKTWDDKLFTTDVRSFANMRKLMFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJJ5</accession>
    <name>A0A0N4UJJ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10204</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJJ5"/>
    <dbReference type="WBParaSite" id="DME_0000783401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000783401-mRNA-1"/>
        <property type="gene ID" value="DME_0000783401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5787100at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000783401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27727" checksum="D4BEFFEAB88BD4DA" modified="2015-12-09" version="1">MLIANNNYRLLFKKICLVGNWKFVQKNFRDFVILANDGEIRTSKYLLYLSMEYFHELFTADSTLNSITLNFNREIIEKLIDFTYKGIFSFTIDKMNELDSIVQCIKLLKPLKEHIVLECIVEMLTEYLMKDWEKLKLDEVVQLLDVSYQHLLTNVFDSAFNLIINKHFVDFQLEYNEQSEGEKRIVYRRLRRSPLNGLLSPINLMISIYNKRQKLYRAIRFCNTSNSYQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJL7</accession>
    <name>A0A0N4UJL7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein Di-Ras2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2011</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000041">
        <property type="protein sequence ID" value="VDN52038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJL7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJL7"/>
    <dbReference type="WBParaSite" id="DME_0000786001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000786001-mRNA-1"/>
        <property type="gene ID" value="DME_0000786001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000786001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5514" checksum="A3A9D72B2A1E24BB" modified="2015-12-09" version="1">MPEQTSDYRVAVFGAGGVGKSSIVHRFIKGTFTENYVPTIEDTYRQMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK57</accession>
    <name>A0A0N4UK57_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2209</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK57"/>
    <dbReference type="STRING" id="318479.A0A0N4UK57"/>
    <dbReference type="WBParaSite" id="DME_0000808401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000808401-mRNA-1"/>
        <property type="gene ID" value="DME_0000808401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810293at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000808401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24585" checksum="B8397E5793F6E5EC" modified="2015-12-09" version="1">MIIIFLSGFFDELQIDEDGNPICIICDEKLKNEREWAEHVEIERSKLIKNINQLKEQKSNYNCIANSSGDHNRRKREFELMRIRANQQKRLAAKNMPNREIKSWNISTTSSDGPSSCSAIINKSDETDGSINTGNYCKSCERYHEYLIISNAFEEARCQECFFKFRAQTGALPLTITTLPTERASSVSHCETEDKHSPQSALALIVENKRPRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKS2</accession>
    <name>A0A0N4UKS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2358</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000056">
        <property type="protein sequence ID" value="VDN52385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKS2"/>
    <dbReference type="WBParaSite" id="DME_0000835201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000835201-mRNA-1"/>
        <property type="gene ID" value="DME_0000835201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000835201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36582" checksum="778078C6ADAA1EB6" modified="2015-12-09" version="1">MGRTLKSEANFRYKCVEEYTTSDDDGNPVEEDDFLYFYGNIPKGWNENEKAKTRKRFLKNMDDKPKYSFIYDEVSNQYDNPKQSWKLQKFISKNKLDYLKLLKPYKLAHWKSPVSKLPKRRLPIRIVERNSKDDETIANFPLKNHLNIRKYDSLRLIKDEFFAPTNFQSLNGINSTNGRENDQKSYEFIQNESEENRANYKKCDLNALLCHKRMRMRKAQEKFNSQSSDPAGVSPGGFGDPAVTLPMPEKVARTKANCQRPRKTSPAQRERANQRERRRMALVNQAYRYLESQLPRFNSEQKLSHIETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL56</accession>
    <name>A0A0N4UL56_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2486</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL56"/>
    <dbReference type="STRING" id="318479.A0A0N4UL56"/>
    <dbReference type="WBParaSite" id="DME_0000851101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000851101-mRNA-1"/>
        <property type="gene ID" value="DME_0000851101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5913344at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040271">
        <property type="entry name" value="T19C3.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443">
        <property type="entry name" value="PROTEIN CBG09852-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443:SF2">
        <property type="entry name" value="PROTEIN CBG15264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000851101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8976" checksum="7340998A1F08EE3A" modified="2015-12-09" version="1">MFGNAVQASNCGEWSTWGPCIWLKGKNPRWNRSYFNQLLPGRNGCRDHIFFKLLRERWGIVSAFFAFSIIFAHPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULG0</accession>
    <name>A0A0N4ULG0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2549</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULG0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULG0"/>
    <dbReference type="WBParaSite" id="DME_0000863401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000863401-mRNA-1"/>
        <property type="gene ID" value="DME_0000863401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3908708at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298:SF2">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000863401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31396" checksum="76D6C5C55DB18EC5" modified="2015-12-09" version="1">MLKYQIRPSNRLNHHGESSKSLFVPDGNPSSSCQDTVHIFNRSNSLTSLSSVESNESNEWGTLKLYMENVKADIDYKTLKISTNHTVRNVIENVISKFRFSCRDINLFEILMELRTMIDGQEVKTLLLLGPSCHPLELQRCHPSDMSRFMLTMNQNAVLVRIYDYSINDDSNYKSLLLSLRTTCYDAISMLLTISRMDRSPSRYRLFIETRPIEMQFCSYNIHSSSNNTDTYGRNNNEINQNSDEIGMNEFIADFYLNLNSNQIIVIRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULI6</accession>
    <name>A0A0N4ULI6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 13">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS2576</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULI6"/>
    <dbReference type="STRING" id="318479.A0A0N4ULI6"/>
    <dbReference type="WBParaSite" id="DME_0000866101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000866101-mRNA-1"/>
        <property type="gene ID" value="DME_0000866101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="250"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN52603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000866101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="71415" checksum="B29A11F21ABB5E87" modified="2015-12-09" version="1">MFASFLQRLVAIRLASVTEMISPSLVTKFDRRSFSREQKKLLKAQQKLKEKQEREAVRSTTADEPEKQKNNDKTDPSDPQEYFNMRLSMINKRRKNGENPFPHKFQVTVSLADFVKKYDHIENGTVLVDTIVNIAGRIFSKRESGGKLIFYDLHGEGLRLQILANARYHNGQESFSDVHDRIRRGDIVGVRGHPARSKNGELSITPVEVVQLTPCMHMLPHTHYGLKNQETRYRMRYLDLIMNPPIKEKFVIRAKIITFLRQYLDNLGFLEVETPLMNQIAGGANAKPFITYHNELDMKLFLRVAPELYHKMLVVGGIDRVYEIGRSFRNEGIDLTHNPEFTTVEFYIAYADYEDLMKLLEDMFSSIFIYLLGVYLQVCFIKKKMVHAVYGTYKIPYNPNGLGEEPVYEVDFTPPFKRVYMYDDLQKILGVQFPLPDDLETAEANAFFSNLAIEKDVACPEPRTTARLIDKVSYFINEMSNFISPTFLIGHPQVMSPLAKWHRSIPGLTERFELFGVTKELANGYTELNDPITQRSRFEQQAKDKQAGDDEAQPIDENFCTALEYGLPPTAGCGIGIDRLTMLLTNSTNIKEVMFFPAMRPDEQKSVHQGFVDMEKTDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT2</accession>
    <name>A0A0N4ULT2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SLED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2661</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULT2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULT2"/>
    <dbReference type="WBParaSite" id="DME_0000877001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000877001-mRNA-1"/>
        <property type="gene ID" value="DME_0000877001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871951at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20095">
        <property type="entry name" value="MBT_SFMBT_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="197"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="SLED" evidence="7">
        <location>
            <begin position="453"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000877001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="801" mass="92059" checksum="57ABFCE7557BAD68" modified="2015-12-09" version="1">MVPSCSGPLQSEKILDVEMDQQYMDLDDGKRDSFRYCLDGIKILHVGRRIKIKQENGEIIRGKVELVCKNKLLVSIKDSVEWIDVDAVVADNDNEVAPSMVEEKNSGMKNRINKPLTVEDLAVGSSNPVELIKKGQFLELQDSRNPCIVHIAEILLNRGGLLTLYYNNRDETTFFTNERCHEIGWVSKQEQCCEYSTESSKLLDKARLNAVPHYVFGFTIVPEHKLEEEMMVEVLDTTTKGGIFYPGYISEILNRHYFRVRISQKINGPVREILCHRWSPYIFPVHFCERQALRLTPPQDYGLETFTWDNYRQKCNLSKASVPELQFDVPKEVNIFDKLRNIEVFDVRRNIMYPAKIVRSLGHLIWIHKCHIRNASAPTVLSTKSHLIFPCKFAEKNAIPMEHAVSYFNISETTEEDRLKMKADFTCTRIPTFADTDKRFISKVWIEGDLWMPEIFVKRTCFPGPFIDPENYAPGPMPLIMKVIVADLICAAYDPKTLCELISCNRDLQKPYMTIKARRKVKSYNVRLESCERKTEFCGWLRGVCFLLDACPEIYSVVKDDVCHSDCGEFRNQPSMNFHKNIWTFAMNIPTAKNLTRLRRLGKDTNVVATNLTNQSVLGRKRKFCSIYTSHEPSTLSEASVIKKRLKKQRKSVHSKIKTETAEKENTIQPVSQSLAEENEQASQSNLPSDNQESNQSAPTQKLNNELLFESQSVTYLDTCNLPEVTTNPKMWSTPELLEWIKQTHLSFISDRLEKEEVDGEAFLLLSLTECMGGLQLRLGPALKVIAIVKELNKIYQRNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT6</accession>
    <name>A0A0N4ULT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6 9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2668</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULT6"/>
    <dbReference type="WBParaSite" id="DME_0000877701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000877701-mRNA-1"/>
        <property type="gene ID" value="DME_0000877701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851065at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000877701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30284" checksum="D7F77FEE736B6D1B" modified="2015-12-09" version="1">MAPLLTTGYMSRAQAMAEEVDLATKWWNDYPTSKYIERARPTSAYTSYISSVWDKPKSLARSASYTNLTYVKEAVHDYPIRKSPSVSSLAPSLALPQHFREAERFITTAPLYKPHIYDWYNNSYSRARWLDTHAAISKPLRRTFEPLQYSSHVPYYTFQTKRIFFDQAKQKLSSYIEGSRRYLDKYVSARLKADDFAQQYAYTAYEWRYPQDHSFNRHFMYGERVTIPHAPRNPHSYYDSQALRKLYITTGRFRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULV2</accession>
    <name>A0A0N4ULV2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Large neutral amino acids transporter small subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10482</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULV2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULV2"/>
    <dbReference type="WBParaSite" id="DME_0000879401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000879401-mRNA-1"/>
        <property type="gene ID" value="DME_0000879401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000879401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="385" mass="41963" checksum="B285C930988FA817" modified="2015-12-09" version="1">MAISEILQIYQYYIRGKKMATKDTNEKSKVVKNEGKSEEREGSVGLAKSLTLFNGISIIIGCIIGSGIFVSPTGVQEKAGSVGLSLIVWTACGIFAAIGAYCYAELGTLIHKSGGDYAYIMEAFGPFLAFIRLWVEAIVVRPCTCTVVALTFAIYMLRPFYPNCDPPQLAMPLLAATLLIILTAINCISVRLATFVQDFFTVAKVFALLLIIATGAVLLFTGKPEYRESFENIFDNTNPDIGVASLAFYSGLFAYQGWNYLNFIVEELQNPRRNLPLSIAISCTAVTLIYVLTNIALYTVISPDEMLTSPAVAVEFANKMFGPLAFIMPIFVACSTIGSANGVIFTSSRLFFVGAREGHMPLVLTMVNKDTRTPIPAVIFTVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMS8</accession>
    <name>A0A0N4UMS8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2907</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000088">
        <property type="protein sequence ID" value="VDN52934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMS8"/>
    <dbReference type="WBParaSite" id="DME_0000917001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000917001-mRNA-1"/>
        <property type="gene ID" value="DME_0000917001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863398at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000917001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="54628" checksum="67512FB39BF1A003" modified="2015-12-09" version="1">MGFLSPIDRLKMQISCKRFQDSNLAWNDIIAIDVRSDVYTYGDFQQKRPFQLVSSSVTSKILYHIKLINKDGKVFRLRNTIEKFGNKSMEVMFLRLTSLVEITIWDCALGEEFNGTLKFKKSKIYSPAKRLLNTLFSRPNLSTIFILDSCDQINVSYKVAFPRSIVEYIKGPVANFQLTGLYISWRTFDALCNKLSGSLKRLAIGCTYGKNSRRDRYIRALEKLEKLEDIDIPPYVFHLGDSVEIDKRIQRLFQTLPLISLGFRHYNSASLFQYIEFQLPQNIRLLRIHHNKNRIPNFAQLGQPQLEYKSVSRKTSWLSSRQTCMGSSSSYNSIASGTNDDCSVHRRSSCASNGSITSQTTAQSERKNSNISLQFRNLTIFAIQETVRRSMIENISKIDRRYYAGVQIFYIKESLNNQEMLGRMASPMHSPYVYSKSNKREVRIIKGDLVRPIPLSSLGMESDYEMSDWEDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMZ2</accession>
    <name>A0A0N4UMZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2989</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMZ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UMZ2"/>
    <dbReference type="WBParaSite" id="DME_0000925201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000925201-mRNA-1"/>
        <property type="gene ID" value="DME_0000925201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837891at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000925201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23005" checksum="14123C73BDF16984" modified="2015-12-09" version="1">MTELQLMLNNVSETAARIGLRINVNKTKVFSPYVEEADKMPLFVNSLTVEEVPDFKYVGSPLISNARAKDDITTRITAARNAFFRLTKLLWNRREITIKTKVCIYIAVICSILQYGSESWPMRVEDVKLSAFDHSCLRYILRVRRVDKISLYRILLRSYTTCINNVINERRLRWLGHILRRPPQDLTHISLFAKPCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNC8</accession>
    <name>A0A0N4UNC8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3117</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000106">
        <property type="protein sequence ID" value="VDN53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNC8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNC8"/>
    <dbReference type="WBParaSite" id="DME_0000940601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000940601-mRNA-1"/>
        <property type="gene ID" value="DME_0000940601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865779at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000940601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18183" checksum="192A63FFAF03DEAD" modified="2015-12-09" version="1">MFGAKKRREIYSGRQVRSISVPSRRKWYQKISPNHHRRIQSQKNFYSQDINYVSRHLIGAITMWHDIHASLIHLAIGQHEICSDELESISNTDLSSYQSSSSYDYFSNQDDEGLKECETHEKAIKPLGSKMSLSNPDLTADQLKLIFPELSERWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNS1</accession>
    <name>A0A0N4UNS1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3238</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000116">
        <property type="protein sequence ID" value="VDN53265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNS1"/>
    <dbReference type="STRING" id="318479.A0A0N4UNS1"/>
    <dbReference type="WBParaSite" id="DME_0000957101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000957101-mRNA-1"/>
        <property type="gene ID" value="DME_0000957101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="93"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000957101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29593" checksum="B9DD63C8A158F3CF" modified="2015-12-09" version="1">MATNFEHFIGGFAGGIASTLVCHPLDLLKIRFSANEGKRCRPQYSGYLDAVKNIYRVEGLRGLYRGLSPNLTGAALSYGFYFQFYFLFIVYFVLYLYSYHIMKSKSLTNPIWLSKTRLCLQYEIQSDKKYSGMVNCIYSTARNDGIKSLYKGFLPGLFGTSHGALQFMLYNYFKNIRFKELQVTFEYLLFSAGSKIIATSATFPYQVLRTLKNLDSSQLIPEGIRGFYKGLLAGNLRQLPAAIVIFLTYENVRHIIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP42</accession>
    <name>A0A0N4UP42_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3326</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000124">
        <property type="protein sequence ID" value="VDN53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP42"/>
    <dbReference type="STRING" id="318479.A0A0N4UP42"/>
    <dbReference type="WBParaSite" id="DME_0000971001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000971001-mRNA-1"/>
        <property type="gene ID" value="DME_0000971001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60866at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720763" evidence="3">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000971001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44897" checksum="8BC5B832C4E8D96E" modified="2015-12-09" version="1">MKFLYGFFLSLYLLFEICLAFEQRYKIAHGHIADPESYPFVTKISMGERFKMNNKFGVCTGSLISRSVVITAGHCGGNFSASLKFNKTGKFLKLVAKIPSISNNEKYNLFNLLNSAHLLYGSEEMKHYKVYYAAEFYKKRDYEQELYETYRSSGKFHQLMTNEEISDVGEVYDIGLFALERPVPVNNSARIYRFIKLPVKDINATVWMPIDQPIRKLSCETLGYGAHERGYSDENLRRLGIKFHFKYKKTIFSPLLSYDQKGRRCQGDSGGPLICRLHNETFLFGITVGRVGGHGMFPYPVLERNCDGEKFDLLYTISTDLRDFLAAIRNLLIQMGKLDESETKTVYFLSFGYLQNYGLSKCVLPDIDSEHHLVSCSEHLTEHLTEYFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP44</accession>
    <name>A0A0N4UP44_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3328</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000124">
        <property type="protein sequence ID" value="VDN53355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP44"/>
    <dbReference type="STRING" id="318479.A0A0N4UP44"/>
    <dbReference type="WBParaSite" id="DME_0000971201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000971201-mRNA-1"/>
        <property type="gene ID" value="DME_0000971201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000971201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18242" checksum="0B5CD7BAE802CC85" modified="2015-12-09" version="1">MKLETCIYSGYKIYPGHGKRLVRSDGKLQIFLSKKCQRSSKLKRNPRDVPWTVLYRRKHKKGVHGEENVQKKRTKKIVQVASRAVGNVTLEAILAKRNQKPEFRRVQREQAIKAAKDAARALKNEKKAANKLLKDKKAVAPKMKAPKPAKVPQPRVGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP57</accession>
    <name>A0A0N4UP57_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3341</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000125">
        <property type="protein sequence ID" value="VDN53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP57"/>
    <dbReference type="STRING" id="318479.A0A0N4UP57"/>
    <dbReference type="WBParaSite" id="DME_0000972501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000972501-mRNA-1"/>
        <property type="gene ID" value="DME_0000972501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800852at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000972501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34399" checksum="AC438E8DF1C653DE" modified="2015-12-09" version="1">MNSQIDNSDVDLETVAGNVADSLTRIFLLTPRPEVRLKAYSLLGVTNSRDFALEVERRINNFLKISSKGHDRRILIRKMLSEYFLDHLVKDFNLTSAQQMISYEFSSSDLDDFSTGSFSEPAFSDWSSDWSLSSYPTKRKGAKSRKKCENISGICKEYDSFSNSDGKVPAQDMLVDNEYIQSKEYVVSNQSESLMEEFSQDEEIDVTNILRDLVENYCVIQRYAPSENGTVLGVAGCTNSGKTTFAETLVEMLINDGKKAVRISQDAFFKPMDEVERLLDEEDSSISYYNYDRKESVNNFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP89</accession>
    <name>A0A0N4UP89_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3375</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000127">
        <property type="protein sequence ID" value="VDN53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP89"/>
    <dbReference type="STRING" id="318479.A0A0N4UP89"/>
    <dbReference type="WBParaSite" id="DME_0000975901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000975901-mRNA-1"/>
        <property type="gene ID" value="DME_0000975901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="915"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000975901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122365" checksum="223D27A660B18A22" modified="2015-12-09" version="1">MDHCTPKWETSILKTSKSSRKSVSDIVHSFIASFRVDDDLDASLVTLDRTIYKVDLEDCSPKEKLNSATVLIDECASGRFPHLDFDFLQPDKIRDANGRLANDPEYCPRTLYVPDSFLKEQTPGHRQWWMIKSKYFDTILFFKVGKFYEMYHMDAVIGVENLNLTYMRGKIAHCGFPEIGYGRFADQLISRGFKVARIEQTETPTQLEERNKVEKIHDKVVRREVCSVTTAGTRTYGVLDSSDDRSALDAVESAARYLLAFAEKINEAGITIYGVCFIDTSVGKFYLSQFEDDSNRSSLRTLFAHYQPSQILYERGRLSNATNNLLQCVASGIVKEALIPKKEFLTAEFTIKRLKNKSYFGDEVHNWPEVVKKLIDDANTVSPICSSDYIECMMSFGAVLWYLERCLIDVDMITMRNFEWYIPPAYIYQKTAQRFLILQDGAEHIWRDRHLILDGISLSNLNIIPPMNGLRRVVRDSISSKYSLYNTVNKCSTPFGKRLLRQWLCSPSCDSSIISARQNAIQWMLDAERKEFMIKATDHLRKLPDFERLLQKIHTMGLKYRASEHPDGRAVLFEATRYNRRKINDLLITLSGFDRVLALVEEYRNLPSGKSELLQRCFGDQFPDISADLKHFKKGFNHEKAREEGVIIPERGVIEEYDAIIDDINDCIVQLDSYLENVRRNLKCSNINYTGSGRSRYQIEIPESIAKNLGSDFELKSSRKGYKRMTTSESTELFQTLIEAEERKDLIQRDVMRRVFADFDSRSSKWAAVTERIAIFDVLLSLARYAQTSGLIMCRPEFDYDSQKPLLDITSGYHPSLAIKPFSNNDSDFAFIPNSVKLGAKNPSTLLLTGPNMGGKSTLMRQVACLVVLAQIGSFVPAKKMCLSPVDRIFTRIGANDRIAAGNIYWKILKLSSELFNPLMSLLQITIFFAFFSLIFHYISGQSTFYVELNETNIILRNATEHSLVIMDELGRGTSTHDGTAIAYAVLKDLALRINCRALFSTHYHSLCTAVEHISNIKTAHMACVVENENDSDPTMENVTFLYTLADGVCSKSHGFYAAKVSGIKQEISVLFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPG3</accession>
    <name>A0A0N4UPG3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CSD_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10770</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001245">
        <property type="protein sequence ID" value="VDN60797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPG3"/>
    <dbReference type="STRING" id="318479.A0A0N4UPG3"/>
    <dbReference type="WBParaSite" id="DME_0000984901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000984901-mRNA-1"/>
        <property type="gene ID" value="DME_0000984901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203339at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000274">
        <property type="entry name" value="Mitochondrial RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000984901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25136" checksum="045327BAD5FF6042" modified="2015-12-09" version="1">MRSNDTKTEGAQPGPPVQLNDENHVDGKRIMARHIQGTVKWFNVKNGYGFINRSDTGDDIFVHQTAVTKNNPNKYLRSLGDGEQVEFDVVEGQKGPEAANVTGPNGTNVEGSRYAATRMDNRGRGRGYRRRTYYGGFRPGRGGRRAASEGEGEGDEEGGGRRGRGGYRGRGRGRGRGRGRGRGGQRRTASEGGENINNDDGGGERKGGRFRGRYMGVFLYFIHWHENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ36</accession>
    <name>A0A0N4UQ36_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3624</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000159">
        <property type="protein sequence ID" value="VDN53651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ36"/>
    <dbReference type="WBParaSite" id="DME_0001010201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001010201-mRNA-1"/>
        <property type="gene ID" value="DME_0001010201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001010201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9914" checksum="1A21F1E43639192F" modified="2015-12-09" version="1">MDRVQTSVVLFDFHLEECSTLDFGECIMRCIIYKANYKRHRPELLQNDIRSFIRSSITMIIGSSRVTYGYIKSMDLNTAVDLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URG3</accession>
    <name>A0A0N4URG3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4064</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family. AFG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000267">
        <property type="protein sequence ID" value="VDN54091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URG3"/>
    <dbReference type="STRING" id="318479.A0A0N4URG3"/>
    <dbReference type="WBParaSite" id="DME_0001064301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001064301-mRNA-1"/>
        <property type="gene ID" value="DME_0001064301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000567">
        <property type="entry name" value="ATPase, AAA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="503"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="737"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001064301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117667" checksum="D70F1A8F6AEA1437" modified="2015-12-09" version="1">MNVIQRFPCVNTSTQFCPFVRPFFPIPPPFVNIPPPVPPKPDGVVPGPSSATLHNDPPLVNNEKVISDAGTSSSKIITRNTPSSDLNGNSAINQQAVHASTSTSHLISSTSHSSAENRFTNRPVSPRMSCEANRSQRGLPRNQFPFPRGNFSYGTRMRPIFPFRRMDSNLELGPFRDRGTIFFDTGMHPFGIQRSMPPGPTDFRSFDRDRSPLGYHRNGYNNIREHTLCSSIFWGPSCYRWGRRVEQGAPPREINRSELSQECYVETEGKKYTVPVIVPGKLFLGYFQSAEKTFEKYLPPSCTEWEKRNSIFFSSEMMQILEISPRSPCLFRDGPISKIVLTWPCNEVIFFFSNFHLAVMKIFASFKCSKELIAVIPKRLTQTVTLLSLKPKSFHKFYNYDHFREFARVFLIGSYIVPNSAIDIHYYGFICSFDVLLSIEEEFEAASIDEDTMIYEVGVQCSVNIILNKVPSRTLNLSDFGGNEHIKKELIKYLITPMKHGQQTRSILIAGMLGCGKSLLLRILSAELGGKVILIDSNADLDETLLYTKEQKCIFLVDDFDRLLQMAGSRCMPIVDRLCRLIDSGESSVVITCRHADAIDLKLRRRFHREVELVVPPALERLQILKLMLKNENDSVLEDIAIKTHGFTGGDLNILCGLAASDLSENKIATYEEKIACYSRLIKDIRPTGIKEFVLEVPNVVWDDICGNDLLKKEIEQAVIWPSTSHHVAFERLGIEPPSGVLLYGPPGCSKTLIARAIASQSHHNFLAVKGPELFSKWVGESERAIRELFRRARQVAPTIIFFDEIDAVAVSRTGEKSSNNVGDRVLAQLLTELDGLEKKGSVFFLAATNRPDVLDDAILRPGRVDRAIYVPLPDRDTRQIFFFHDLLAILRKHLKKAQFMNDDLLMNKFALTTEGYSGADLVQICCNAGLIALRENINADFIEERHLKILKPKTSGNGSRVGVDVKVFPNSFSTLLLYDGSGYCHCCGIRESGFAEQIFMLKGHCFKCQQHIFIDPAAAFSSVDKAALDNVMKCDGVRDHPTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US57</accession>
    <name>A0A0N4US57_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase_22 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10968</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001325">
        <property type="protein sequence ID" value="VDN60995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US57"/>
    <dbReference type="WBParaSite" id="DME_0001088901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001088901-mRNA-1"/>
        <property type="gene ID" value="DME_0001088901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001088901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14032" checksum="407083274D54D374" modified="2015-12-09" version="1">MGPKKVAAYGAISNNVEDLRSQLASITEKYEKQQDLIMRLTRSVEILTKKEKEPYLVGINIPEKSTDDESATADRLLAENIVVAAWFKTEFIKEVRRHGRKGTGRPRVLKIRLEDKHMAMCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2K2</accession>
    <name>A0A158Q2K2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4666</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2K2"/>
    <dbReference type="STRING" id="318479.A0A158Q2K2"/>
    <dbReference type="WBParaSite" id="DME_0000030601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000030601-mRNA-1"/>
        <property type="gene ID" value="DME_0000030601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000030601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14826" checksum="57F74FCAD953B074" modified="2016-06-08" version="1">MPLSGFIIHIVYDSHNKIFLYGTPADRAGLCIGDQIIEVNETPIQDKSHNEIPIYLQCIKSKVIQLRIRRKQNMDSNCLHSDRSFRVSDAFFVSVDKDHAKEIGRKLKRLAFPKFMPNIQPSIMVGTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2K7</accession>
    <name>A0A158Q2K7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">MAP/microtubule affinity-regulating kinase 3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase par-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DME_LOCUS4685</name>
    </gene>
    <organism evidence="28 30">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27 29" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MAPT/TAU. Interacts with DLG5 (via coiled-coil domain). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5. Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ. Interacts with PKP2 (via N-terminus). Interacts with CDC25C. Interacts with KSR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2K7"/>
    <dbReference type="STRING" id="318479.A0A158Q2K7"/>
    <dbReference type="WBParaSite" id="DME_0000032501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000032501-mRNA-1"/>
        <property type="gene ID" value="DME_0000032501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12196">
        <property type="entry name" value="MARK1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14072">
        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001032">
        <property type="entry name" value="KP78b, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049508">
        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="204"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="25">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="26">
        <location>
            <begin position="1134"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="544"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="835"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1020"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1039"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="VDN54712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="WBParaSite" id="DME_0000032501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1183" mass="128267" checksum="432F32429258E3AB" modified="2016-06-08" version="1">MSKDQVKKDQMIPKISKTKHLLESREQNVKDSPLAISQQNKIEGVTAVIDCSKPTQAKISSETSKSSPQGKILIEAPKVSLKSSAQSSQQSANKSSKSAQQKYSPTRAIPQQTPTKGVLRMATTTVQQHTAMTGPSSSAHHHTNPIGVTHFNSAQPSHHGAHPSSSSTHHNSGGQSHGSHRSTLSSSRVQGRSRTTDDPHIGKYKLLKTIGKGNFAKVKLARHMTTGIEVAIKIIDKSALNPSSLHKLFREVKIMKQLDHPNIVKLYQVMETDQTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHQKNIIHRDLKAENLLLDADMNIKIADFGFSNQFVVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPARRGTLEAIMKDRWMNIGYEDDELKPFGEPKKDMKDEKRIELMQQMGYSRNAIMSSLEQGTFDDIHALYILLGEQKHELDSEATLNIPVAPVSTQNVSAVPHGITQSQAQHSHSTHSPKYGLRSMSAQVPSNKTSRRSSQDPQMQAAIAVLSPPATNAVDSGGNNSNATRNSGITQVALRHGVGQSNTRQAFSMQPGHIMPGYPQSVMPVIGATPRGGSVGVAGTRKASIPGRVPLANLGVRSSAMTGPQRYVYPNAEPKSPTGNNGSTSARGLPTFSLVVNPSVHLGTHQKPQAVLSNISAGAAQLQKSGSISAPPTEPVIKEDDNENVDSSITDDVSAQEVTCLSDDGGNGNTVNQSTTTDIVQQSELKIDAKLTAICQWYICLTFYRPSMHTSPSMPPITMKNMSTNESSSQESRSESPKLTKSATGNVLITPQTTVGSGQPQLGAIGYSNLPTVLQNPAFPRHTRSRQTFHGKTEHNKVNTDEDDTEAETVHTGVASAGGGGPRGSFLSKLTKLTRRPSITTTTSGTTAVSRSIISGNHHRYVSHVSFALSLQPVEGNYLLLATIAEGSAVTTPAPLTSPEILTPSGGRKPGSTAFATSPANAVTGNSGPQHHFHVGFNPVPTVTTTTCGGATGGSDEVKPRSLRFTWSMKTTSSLAPEEMMREIRKVLDQNNCDYEQRERYLLLCVHGDPNTDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q334</accession>
    <name>A0A158Q334_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEC63 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5888</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q334"/>
    <dbReference type="WBParaSite" id="DME_0000152801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000152801-mRNA-1"/>
        <property type="gene ID" value="DME_0000152801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000152801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27761" checksum="4EE3F7F22E173F13" modified="2016-06-08" version="1">MIDKGTQSEVDSRRLRDVCCETDFEIFHIGMQRNSDSISYSMNFDKANSELLNLLTPPITPDRMHLIDRIQLKPFRSKPLQRDERLKIFANSRVGNKLPTAIPGAEHYALKFMKYDIRYAYQLIGKYLIINGNRLSFINFLKNEFCMDTLDAYNVHDAITMRIWKTQLTEIKTIYGLNDQNVECLIANGYTSMSMVIGVYLVLLKDSKLMLKFLRKMAALKGPLSSFELDAIADISVLVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q382</accession>
    <name>A0A158Q382_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q382"/>
    <dbReference type="STRING" id="318479.A0A158Q382"/>
    <dbReference type="WBParaSite" id="DME_0000185001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000185001-mRNA-1"/>
        <property type="gene ID" value="DME_0000185001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000185001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="62686" checksum="7C099FABDBC0A556" modified="2016-06-08" version="1">MFKGLEHEGAIVGWSRRKYFRESEEWRKKKTRLLMKLRAIGRLNLAFIMARAPAIEKLPDRVLQHIFSYLSPIQILRVGQVCRKWKDIANSPSLWQFISFRPNYGGLQVTNQEIFLHLLGTRFTDLRVIELATDLITPTVLHELSAKCPALQSLTLDFSTAMQLHDFTELQSFPSRLNSLTICLSENIFLEGFLRKVYTFISSMEVLHIIGTYEKVEDEEEEVYETVNVYKLKQYIPNVRVVNLWGVPFITDEHVDAISSNCAHLECLSINYCTKVTGSCLKLVLQRCKKLRSLHLAHASLDDKLVQNVDWEKTRIEELNICGTELSSDSLIIILTRLKNLRWLNASWLEQMDDKVMEAWMASDAIANIQYLNLDTCDSLTETSLTDFITRFGQQILGLNLGGHHKLLEYFWMNMIPKLRNIKVLVMGTAEDCCLKVIAKIHIDQFIDCIAQNCFRLRRLEIRWDDETLRFSDKSSKFIDILRLKCLKLHSLVLSDGQYYELVRSNFERADRMSVVRTTEMCRTGLMHCSHYYSQLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3R7</accession>
    <name>A0A158Q3R7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7187</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3R7"/>
    <dbReference type="STRING" id="318479.A0A158Q3R7"/>
    <dbReference type="WBParaSite" id="DME_0000302801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000302801-mRNA-1"/>
        <property type="gene ID" value="DME_0000302801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF274">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000302801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="35668" checksum="E868B93911CC8DEF" modified="2016-06-08" version="1">MGAKACIGLAVATSALFITITLFFIASLFNDINGFYTDMMDDINQFKVRVNFMKFSFPYKIFYFKILAQDFGTKSNGTDRKKWFLMAYLLLYLSKKEELKVTDETWHKILILRIGSSSKGYLSDGLENILTRYKRQTFPERCNCEGRRAKCPAGPPGPQGDEGESGPDGLDGEDGRPGVPGVTLAATYHIPGGCIECPPGPPGPPGPPGIEGEKGPKGRCGERGLAGPPGKPGQVGPIGNPGPQGQQGPLGKPGILGKDGKRGSGPPGPKGRTGIRGPPGLPGKDGKKGTDGEPGQQGPSGRRGRDGKQGTPGRPGSPGKQGIPGPDAHYCPCPMRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3V7</accession>
    <name>A0A158Q3V7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Low-density lipoprotein receptor-related protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7444</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3V7"/>
    <dbReference type="STRING" id="318479.A0A158Q3V7"/>
    <dbReference type="WBParaSite" id="DME_0000328501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000328501-mRNA-1"/>
        <property type="gene ID" value="DME_0000328501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72419at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF44">
        <property type="entry name" value="LDL RECEPTOR RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1474"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="478"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="664"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="936"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1289"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1332"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1610"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000328501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1686" mass="188661" checksum="945128A1302C854B" modified="2016-06-08" version="1">MDCNSQRLSIITPLILLYFPLVYTSFFQVANSSEITLVARRQRSIVRLTLDVSKNRIASTSTVVSGIDESFPVLISIDIAQNVLAYMESWSRSSSGNIRLTSLLGNSSLPAYVLRNSDVIEETVTSIALDWVTEKLYVGIETTSIHNSGRIEVCSLDGSVKCAVVLYSSFSNAKSRVDAFHSLVLDPVDGYMYWLNRLHKRIERAWMDGRHHELHPFKDDTMDIVATAALSLDQVVLIFVFYNYVKMSRSLYYVRTRISPDDSQIWRCILYNRESCTLVAKKVNAFYLDDLLIWSSVTNQHSGIMICDATHCESSMREVENSSAVEALKILDINTQPLKSSSNQCAISNGGCSHICVLIPGAPWRSCLCPVGVRLLEDRLTCAPNGIDRILLVATASGLIHISLDTDDYTPMLLSYASTNFTDAKIMHVDYDPIEKKLYFIDGDRGVIKRCGFNGTEFEIFVKDAFKSEALVVDWLNRNLYWVDVDVAEIKMQSLTGKHQQIIISHDLMQPRGLAIDPIKGFIYFSDWHESMSRIERAYLDGSHRSILISLERNAWPNGIAIHTEENRLYWAEGRKSLIKSARLDDGSDIKIFSTKINHPYSLSILNGVLYCNSLHGRRIVALRLPNRKYSSSDSMNVISDSVIFGQMGIRAVNLNRIPIGSSPCNIENGGCSHICVKLPNGSRKCVCPVAHELLGDHMTCVMPDAFFVYTLSSKINSGSIMRISLEKNPANMRVINIANFSSVAHSVAVDQNRQRIFWASEIRGRLIYSRMYSSFFNGSDLRIVVESASISHISVDWITGNIYWCNVEERRIEMARNDGLARRTIAWKKIIPRYLAKCPLEGDQLGGVVLISGIGHLSCLTIDFELHRFIWAIIDGDIGRIFASDFSGENVVQLAHSNSLMPVAFVAYNKILYFANGKTNSIDFINGKTNIKWNKCIYNNGNCSHLCIPSFHNDFVRCFCEDHFLLDVNNGKCLPPKRFFLVAVEGRLIRFNLKQITDSDNEFLWKQDAYASLPVKNVGMPSSIAFDPYSSNRFIYWIDSYDDKQIKRSSDLSVSKTHSISLARYSGCSFLFSLAVDALGRQLFVSCAEQGLSHASSIHVWRIKNNDQLEYIGIVVSGRQRSSVTNRPPYPRQIALFPRLNLLFYVDIGGKIPIIVRCFLDGRQCSQWEVINSIAKIYANEANERLYYTTANGLWSRDGHVYSDVRHHINTSPSHIGMIPISELQLIIIAKNDSLNGDIMIEVQDDVPTVSLEQLKWDDTTSLSIGRILASTVVGVSGLDSADSINHTCSTSHCSHMCRIPRDSRKRYECLCPFGYGLQYAGGTSCFELVTCANWQFKCENGQQCIHFMGKCDGRFDCNDGSDESHKWCRNVAIDSWPCDGGKASITRNLVCDGKSDCGDNSDEAHCRCSNPSLYFDCALSISATDSNECINRELLCNNIADCLNGKDEIPSFCKQSMYSTTHSPSFSHSFEFMVPLMIFFIIFGLIIFACCLHLSSNQTFIPQNLSRPMNTTAEARVLLPTHPNGTHVEFQLRTYSVAASSSICNALPPPNLQSTSDGSYHFNGPYSVNSSSFDTPPKSEFFNFYAPPPSAASLSTYGVVKPAGMRNRVDSRAIGSSSRKGRRKKIRNQIPNKSNSPPPSYSQVTTDRAIFIDGEFDTKDGARAPVNSRIVSSVDSSSVADNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q419</accession>
    <name>A0A158Q419_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Origin recognition complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7816</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q419"/>
    <dbReference type="STRING" id="318479.A0A158Q419"/>
    <dbReference type="WBParaSite" id="DME_0000381101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000381101-mRNA-1"/>
        <property type="gene ID" value="DME_0000381101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="1">
        <location>
            <begin position="201"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000381101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39629" checksum="82D4FB0A9FB77BB5" modified="2016-06-08" version="1">MLLNCTLLDGSQRFFCREVQSNLPFKSGAYRNNCDTLERLCEFIENTIQVHEHKRFIIIVMQNAEALCKFPTHKGSLKFITVSTLPWHKFETCEHTSSPAQFAFPGFSKDDILNILCQKLPHNRLYLKLLLDTVYITCRDPDRLVHLIGKKWNSKSFNKLIDSDNSKYTTLLPELKRFSNYLFYGIDESLKVNEVEFIDVPYSTKFVLLASYCASYNPSSSDCQFFTKNHRKQRRKAFQRIKKDAAHESGPKSFELQRLIFIYLALIDLYGDKSRANGDVRLAVNISILTFVCDLIAMGCLGRISADGNIDIPKFKCLASFETVNHLSNSLGIVLRDHLYDFAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4D0</accession>
    <name>A0A158Q4D0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SUEL-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8484</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4D0"/>
    <dbReference type="STRING" id="318479.A0A158Q4D0"/>
    <dbReference type="WBParaSite" id="DME_0000460101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000460101-mRNA-1"/>
        <property type="gene ID" value="DME_0000460101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979716at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF9">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="3">
        <location>
            <begin position="149"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000460101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="54091" checksum="4F61A15BF3317FEC" modified="2016-06-08" version="1">MRSFDQHENIESICQRSLRGDALMTTLFRDHPIPQHCPFESPFNFTYSFIDGSCTSRTSSVTSCADSHRFRFLYQACPEMIYSQTHAVELECIGTWRIFGTEYFAARITNSLTQSPPSNLRCLIHEKQNSNGRIGISADASCDSKIISLCHFPPFLLRNHYSVIHHTWKSIVTDFVHHFTKEEWIEKYAGRNKSVSKCIEKEHFGNTYKLIIYATHGCNSGYQCVEIVRKKKNVVQIIRGKLTNNEFTTCSDMTDNANIETLLLEDAEVEIFDYNLIEAKMRCAFQAERCPIRGRYSALNCPSSIIHFGCLLNRSVKYELYCNSNYTQDFICRSHWTENNTLYIIVEEIDSLETACHIYSYLSDDIMNVRSYRHTVCHSQTIQQYTPEFELNLSKYEDCQPTISAWETSNGIQIKPYYFHIWFYVVLLIVTYFKYLRCSVVLLLSLWANIVAHFHVIGDYISNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4T7</accession>
    <name>A0A158Q4T7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS739</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4T7"/>
    <dbReference type="STRING" id="318479.A0A158Q4T7"/>
    <dbReference type="WBParaSite" id="DME_0000569401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000569401-mRNA-1"/>
        <property type="gene ID" value="DME_0000569401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053302">
        <property type="entry name" value="CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058960">
        <property type="entry name" value="Ctg-1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159:SF6">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159">
        <property type="entry name" value="PROTEIN CBG07705-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25883">
        <property type="entry name" value="F28H7_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="89"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000569401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51744" checksum="B8A2B539B6997355" modified="2016-06-08" version="1">MKNASTNFGEPLSIESRKLVNELRLKINQPIHPNFDTDFNLYRFILAAERAHKKEKEIIDVAAKAINSHLRIRKALNLDHQPDVPFEKNELFKNRYLPMGQILSVTDSSNRLLWYVEYATINVEPLAHIFRSSHSIRLQFLQYEHMLRTVNKQEEKTGKLSGLRHIVDLSGYEINPFMMLFVTNGSLTYYSHLFHYENYPELVGPIDMVNIAKWIHVPYKIVRTMMPMGFTERFRLHDDNFLGALKDIKIEDIPTTLGGKNEHIRCTPAIKVTSEMHWKPTNIELLSNLETIHIPPRKTRQIHIDITESHRRMAWYFTTDGEINFGIFYQPFEELPSTGAINHMRTTEKEIDTDQLEMIYPWFKLSAKLVHETDSVECIQPGRYWMIFCNKLSWLHRKTINLSVQIADNNFDNIKRYHTDGTYSNSKLFEFPNIQLYSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4V9</accession>
    <name>A0A158Q4V9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS9382</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4V9"/>
    <dbReference type="STRING" id="318479.A0A158Q4V9"/>
    <dbReference type="WBParaSite" id="DME_0000585801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000585801-mRNA-1"/>
        <property type="gene ID" value="DME_0000585801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF503">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="492"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="840"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN59409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000585801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115341" checksum="BC82A1398FDB2A24" modified="2016-06-08" version="1">MIPLVIFQIIICILLNATNGVVIKVGHLLPQKLQVQHEPEVLKLCVKDLEKRQILPKNISFEIITKVSCIKFCGVENAAYLHFLYNASLFLGPGCIEEMTVVGQLASRWNTPIIAHLSGADYLSNHSIFSTLGSVALTSAHEMARATFSLLHFYGWKKIAIVRPVADFEKLSIHGLRSFTKHGLTINEEIIIDSDATVDELISSKTFNSIQSAARIFVVELGLDISASVNFILAIHKQKMRGNDFVFILPWLQHKNEFYPWEIVKKSNGHELKEAYDNTFIITANGYNRKYVKNFQTKFSRETGITSEFFSTLVYMSLYDSLYLYALAVRDAYDIAKDEDVYKDGALIWNKMTGKQFIGMTGQVLINHKAERVPSYTTFLIKNGELQNVVEFEAKLGDSRSCQLKDEHCSLHVPHELLVNYWPSPSGVMPPDFPTCGYDGALCDYTIYFIISGAIPLITSLIIAGYAFYRIQYNRMLYDMTWRISRHSVKLLDETCAKSRSSMATSITSRSKAAGQQAICDGVPLTFIKFIQLKNISFSKNHLRLLKELKTIENDNLNKFYGICFNQQNELFILWTFVPRGTLEDVLFNSDLKLGRNFQVSFAKDVVKGLLFLHSSKIECHGFLCLQNCLVDSSWNIKLTNYGLHALINEKLDANDIKRVEDDENTINENASFKKYVQQAPEVIRVLLTTKELPKPTQAADIYALGMILYQILFRLEPFYERTREKLLEKIAMCSEDDQCIRPTFPEISSEEGYNLQLLSALEACWLELAEMRPTAKKMKVIVNANLKSTERGSLVDQMIKMMEEYTTNLEGLVKDRTALLEEAQQQADKLLYNMLPSATVLFSDIRGFTKLSATSTPFQIVTFLNSLFSGFDAIIAEHDAYKVETIGDAYMVVSGLPKENGNSHVQNIADVAIKMRDFVANFKLAHKPDEQLMVRIGFHSGSVAAGVIGIAAPRYCLFGDTVNTASRMESTGVPNKIQISEQSFNLLHCFFPQFKINERGKVEVKGKGECITYFLEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5C7</accession>
    <name>A0A158Q5C7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P66_CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9805</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5C7"/>
    <dbReference type="STRING" id="318479.A0A158Q5C7"/>
    <dbReference type="WBParaSite" id="DME_0000700601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000700601-mRNA-1"/>
        <property type="gene ID" value="DME_0000700601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8186989at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional repressor p66 coiled-coil MBD2-interaction" evidence="8">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000700601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="79519" checksum="34B2D15ECA013FEC" modified="2016-06-08" version="1">MATKSEHRRPPEGTSRGLHEQIDTHSPDETQINGFDENSSCPPMSMSYEANKPQSSSKNALTNCENGSQPAIDRTYQASFRRRSTRACAIKAAERIKLKESLTPIMDGLASNSGEGYMSCDEDINEDGPKPPKVRRMAEGNCLDQMNSRFGIKMDGDDVLLMTSESEFSSLDGEEFEQIKKSYEKTVHKEMAENQRRETEMQVKKLEAELRAEEAKLIILKKVMLSQKVSFKQLQEANVRKMTANVSQNGSGNAYKPPVATPHNRTNVNSSTCQSKGSSSINSSRVAASAAQALMNLTPQQQQLLQNAAKSGILNTVAAQALLQQVQQAQMNGRVNPQHAAALAAFAQQQHPSRGSNVANPSSAKESPAQKAAAAKLALHRQLEQQLLQIPPPQPAPPDMHFIPNGNQPDFFITFAITIILCYRYLRRVSEEPYICEECGSDYTPIWRAIGADSDSLHLYCEACVKAAQKKKMRLDHTAVLRSAFNKVLEKEQELDKQIAEGKYDNPAPSSSTPRSGTPAATPPSSKTQISISSAQANTSKSVSSSSQGHPHHHSQSNKHSSHRRPNIGTSSGNNALTSHNAGAAAAALAATSSNTNPSVLLQQQMAAAAALRHTNPMLAAMMANPLLNAPNMLQMPWNPLLQQRLPNFAMAALAQAVHSAQQSGGANVANPNSAAAAAAAAAAASLNPLTALAATMSPAAAAMFSNPQMVRQFQQAQQVIHRNILLEYAKNQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5S0</accession>
    <name>A0A158Q5S0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2192</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5S0"/>
    <dbReference type="STRING" id="318479.A0A158Q5S0"/>
    <dbReference type="WBParaSite" id="DME_0000806701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000806701-mRNA-1"/>
        <property type="gene ID" value="DME_0000806701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000806701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16128" checksum="C3E7B3E368470703" modified="2016-06-08" version="1">MLISSVISAFITRSYKELCEFDCQLHCCVFDRDRSRLKELTESDCVRNNLRVQIEEYLTRLSQITGRRLINCFLVLKFLELDSRGNQYLLAEETSINTPAIACAIVTKDFEAQSCEQLSLRVCSIIYRKSDMGGSNYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6C3</accession>
    <name>A0A158Q6C3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3311</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000122">
        <property type="protein sequence ID" value="VDN53338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6C3"/>
    <dbReference type="STRING" id="318479.A0A158Q6C3"/>
    <dbReference type="WBParaSite" id="DME_0000968201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000968201-mRNA-1"/>
        <property type="gene ID" value="DME_0000968201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000968201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13909" checksum="02EE19CF3C6DB157" modified="2016-06-08" version="1">MSAIYRGLCRIGDKYIYPVLPSFAKAVWNHEAGPKTVFFWAPTIKWCLVGAGVSDFTRPVQKLSVYQNAALCATGAIWARYCFVIVPKNYYLASVNIFLCLVGLVQLLRIANFEWFSSEVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PAK1</accession>
    <name>A0A3P7PAK1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PAK1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF90">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="307"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="914" mass="103910" checksum="F6F4FC3AB85BB89E" modified="2019-02-13" version="1">MHINSMDLSGRNEKELFDKNNVTSSTFAKNNDDKHLRLGFHNIKYGFLRILGKLFLSVGYLIASFPYVFIIFTLLLSMISYGVIYLRFAPRLQDGFTSRDAPSHYEEEISFRFSGTDYAYMQTFVALIQAADGGNMLRPEYLTKALEVHKYLNESLIVNVGHEKFRHTDICGQCCGVNKALQILKVLYEYSVAQHLFGVKKYVRKVKLPVDLKNGNETSTKEVKTKVNTSSIDLFANENIEHVALIMLLFYAVAPTPKLVDMVTSWEEAVFEWTKAGAPQFPELRIDVFGDKVLSLEMFRGGLSMMPYLFIGLCLSVMFVMLSVIVSSIENRRIDFGKILIVIGIILSPLLAVFTTFGMIGLAQVEIYPIQMVIPFLILAIGVDDAFLMLHAWKRQLPTYDHLSIDERYKMIPFMFGKILEEVGPSITITSLTNAIAFGVGSTISTPAIQLFCLAASIAMVMDFTFELTFFGAFLSLAARFEKVFNHLLHCYCQFITMNMTRLFILIFILIFFTVSLIGTLRVKTYINAQKIIPYDSPLLTADTLFKNYHWKEYEPLQIYVNRPPNISDSKQLAELKTMIEDFESLPQAIGSSSTIFWLYDLEKLIWEENQLMAFMGIEIGISYDHLPRFLEHFTFWQDFVRWSMDPLWRDVADRWQKFNVTIYSKNAAVYEGIFQLKGTTIQTAAITLVCMLIVCMLFIPSVVGILTAGWAICSISLGVFGFLSWWGLDLDPVTMSAIVMSIGFSVDYTAHVSYHYQRSQQLLPSYILHSFHVLQRCIEISYLSVSFLFSKLYSLGSSKTDRLIYTMDSVGLPMIQAAISTLICFLPIAFHPDYIPSVFIRAIALVVGWGLLHGLVLLPAILTAIPDCLYIGNIEESASFSWQKTALENLSSHKSHFTFGKGRTLWLRNINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PEC3</accession>
    <name>A0A3P7PEC3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PEC3"/>
    <dbReference type="STRING" id="318479.A0A3P7PEC3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="317" mass="36566" checksum="4442EB55D39EACEF" modified="2019-02-13" version="1">MSKKISMVTPYIWPKKNIYLQIRVILCLFLLVIGRFINVSLPLYNKWIVNGLTHPDPSIYKLIIISFFLKFLQGSGAMGGFILSLRSLLWIPIQQYTTYEIQVELFEHLHSLSLRWHLSRKTGQVIRIMDRGTSSIDSILNYTLFSVLPTFADILIAIIFFFTTFSVYFGLLIFVTMILYLVITIFISEWRTKFRRDMNEKENFSHAVGVDSLLNYETVKYCNAEQAECDRFSHSIKNFQNIEWKTSASLSLLNFCQNSVIGIGLIIGSILIAYFILNDGSTLTAGDYVLFTTYMLQLYVPLNFFGTIYRLVLICSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PTW2</accession>
    <name>A0A3P7PTW2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000337">
        <property type="protein sequence ID" value="VDN54183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PTW2"/>
    <dbReference type="OrthoDB" id="5852176at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017958605" description="LITAF domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="42" mass="4765" checksum="9D8A20FBAB3FC053" modified="2019-02-13" version="1">MAIIGCLFFIPLAVVPFVVHSCKDVLHYCPNCNTLLSIRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PZN4</accession>
    <name>A0A3P7PZN4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PZN4"/>
    <dbReference type="STRING" id="318479.A0A3P7PZN4"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="143" mass="16206" checksum="A2B7286A37AEFDA9" modified="2019-02-13" version="1">MRRLRQFCRISRKDAVKRRYTKKHEWVCVENNVGTVGITCFAQEALGDIVYVELPDVDSEIAAGDSVGAVESVKAASDIYSPVSGKVMEKNCEVEENPALINKSPYDEGWLFKLKLSKKEELNELMDEVAYNAFKKMDEENAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0A9</accession>
    <name>A0A3P7Q0A9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001249">
        <property type="protein sequence ID" value="VDN60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0A9"/>
    <dbReference type="STRING" id="318479.A0A3P7Q0A9"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053352">
        <property type="entry name" value="FMRFamide_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="30"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="316" mass="36049" checksum="E8DA73EE687776C9" modified="2019-02-13" version="1">MALLTDNVLRNASIYCTLIMIIMCIIGIIGNSLSLFIYRGPSFRKRSINILLAALSATDLCLCTLAIPVFSISLIQSASKYLTGHILIFAYPVTLMLQSMSVWLLVGITIDRYLAVCHPFKARVHCTCARAKLSICIIVFFSVAYNFVRFWEFKFDDADGIISLEDSIVPLLRGDHLFMLLYQNIATLISQFFIPLIVLCVLNLRVAQTILQASEQRRQLVASEKCEYNTARMMFFIVIVFIFCYALSMILNLVEILNEDLFRQPIGYLLNDINNILVVINSSSSFIFYTFYSTSNANLTRSSEHYLFRKIFYVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q2M5</accession>
    <name>A0A3P7Q2M5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ion_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10658</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001233">
        <property type="protein sequence ID" value="VDN60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q2M5"/>
    <dbReference type="STRING" id="318479.A0A3P7Q2M5"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="76"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="15">
        <location>
            <begin position="445"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="62222" checksum="4C4BAC0629066CB0" modified="2019-02-13" version="1">MPSCSKKLNLTVSNFFCCLISFKKNLSPQYSRKMSLVGKPLVYKNYRTDERFRRVQSKMHNFLERPRGWKAAGYHFAVLIMVLMCLALSVFSTMPDFEEQATLILYYIEIVFVFWLAVEYICRTWSAGCRSRYRGLVGRIRFATSAYCIIDIIVIMASIIVLCMGATGQVFAASAIRGLRFFQILRMLRIDRRAGTWKLLGSVVWAHRQELLTTLYIGFLGLIFSSFLVYLCEKSTNEKYSTFADALWWGVITLSTVGYGDKTPETWPGKMIAAFCALLGISFFALPAGILGSGFALKVQQHQRQKHLIRRRVPAARLIQCMWRHYAAIPESCSIATWKVYLAPTETSPASLINRLKQSTKKRPSNAIMKTLAIPKHTDNISFISTSDYSEVESLGTLGFTLGGWKSKSKGGTGLKKVHDDCFTSHRVVTSGSSLDEEYPSLQPRTIDDFTPLLKNVIRAIRRIQLLVARRKFKEALKPYDVKDVIEQYSAGHVDLQARVKCVQQRLDQIVGKPKDDSKVSLIHRIIVIEMQVNFMFCLNFNLIDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q6L2</accession>
    <name>A0A3P7Q6L2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q6L2"/>
    <dbReference type="STRING" id="318479.A0A3P7Q6L2"/>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="214" mass="24965" checksum="00AA5D8C8A96B486" modified="2019-02-13" version="1">MRSKKIFSARKTEIFGNILFFSVMNIFSPAQTLGKYPCKKCDRRDFDTIRELSEHEIRAHGAVIPCPHCSRDRSSVQKLVDHLQRRHGTSRLVCHYCKESFSSRIETAKSSIIDDYRAHIYKECLKEKMYKHERLTGRSGAIAQRGRGRCPHGPPVKCKNFPSCPGDKCYYFHGFCRHDLNCTKKDCPFDHTNRPRTCLSCLRDLRVCFCLLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q921</accession>
    <name>A0A3P7Q921_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q921"/>
    <dbReference type="STRING" id="318479.A0A3P7Q921"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="360" mass="41226" checksum="CE0127B81558528C" modified="2019-02-13" version="1">MIQIYFRTLFNILLQSDLCKVRALDLVERATTSIWPGTTISLLKFPVMNPTPLRLELRRRRLLKFRSWLMKERRLSRDILKETGDSKYVTLHAYVDNTFKDMDEKTRPVAPSNLAYLSNEKMFINTEQKLRDIKKRSWTLDHEAFAKGKWCYDTPGTVNNEQVLNIFTLDELIAILPKKMMVPRTFVVKPNETLLIAGIARIDFLELTADERGPTFLSVFANDSLPVNVMKTCEVKAFFERYWGSPALVVPFGSTKRLSDFPEMKSQKISFDSNGLEIGCADVIFSSIGWVCVTAPKSKIRLEAYTPGGRGLSLRVPPILPLCASNRGPRIVGTAAYKVKRVKLPVNMTRKWKKRNLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QI51</accession>
    <name>A0A3P7QI51_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QI51"/>
    <dbReference type="STRING" id="318479.A0A3P7QI51"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="908" mass="104622" checksum="EDCD8F8399B6F605" modified="2019-02-13" version="1">MHKVGGKVKKKNRRIGTKNVDAKAYTFRSAVKAGRAIRRAADKGERKKHIPLVDRTPVEPPPYIVAIVGPPKVGKSTLLRCLVKHYVRITLTEIRGPITIVTGKTRRVTFTEVCSDISSMIDIAKIADLVLLMVDASYGFEMETFEFLNICQVHGMPRIMGILSHLDVIKKKEKVKHAKKLLKHRFWTEVYQGAKLFYLSGMINEHYLRNEIHNLARFISVAKLRPLAWRIDHPYVYCDRYEDLTNPEILHDNPRANRVISLYGWVRGTFLKSHSAVHIPGVGDFRIKEINALSDPCPLPSKEKVKRTLNERERIIYAPFSGLGGIVYDKDAIYIDTGGSHTFRKPRHELLRALDNIKQGIDDKMGKMGLKLISDAKNDLIETDASGEADDIEEGENGFGNENETVGRGDIDEDESRESCLTDDSWSALSKKAQSMYELKKQSRFKWSTVVYNETESGFNSVINSGNDRITKIRVTAAENRRKNDKERLKNKFNAEYDEANRYYLQLKDEFEQQAKLNKSVFDNLDEDVRQKLEGFRPGTYVRVEFENIPVEFIDNFDPTKPYIIGGLITAEQNFGSLQVRIKKHRWYERILKSRDPLIISCGWRRFQTVVIYSMQDHNMRQRFLKYTPQHMYCQAVFWGPVVAQNTGFLALQSLTETMGFRIAATGVVLNLDKAFEVVKKLKLIGYPYEIFKKSAFIKGMFNSTLEVAKFEGASIRTVSGIRGIIKKAQREPHGAFRATFEDKILLSDIVFLRSWVTVPVPRFCATVTNHLLRSDTEWEGIRTVGRLRFERGLKAPMKNDSVYQEIKRRPFESAPLVIPKTLQKDLPYRLKPKYVKNIKVLDDRLISKHTAVILEPHESKLHRFLEMLDVVNADKVKKNREAMVERVKKHRKVTYYAIYLCYCVCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7S844</accession>
    <name>A0A3P7S844_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7S844"/>
    <dbReference type="STRING" id="318479.A0A3P7S844"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="180" mass="21310" checksum="65620C28EF99E078" modified="2019-02-13" version="1">MPNFYNLQDVGEKKRFIYEAYDVIKKAIDKSEKDCANAHKWYGIILNYIGEFEGYRQQILNSYEIRKHFEKALAINDKDPTTWHLLGVWHFACADLSYPLRLIAKTIFGTPPLSTFESALEYFEKAESPNFYSRNTWYLAEVYERLGRYDEAKAFYLAAFKMPIITIDDIEVHRMVDLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SC82</accession>
    <name>A0A3P7SC82_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SC82"/>
    <dbReference type="STRING" id="318479.A0A3P7SC82"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF98">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22642" checksum="9F6929129AB53009" modified="2019-02-13" version="1">MKQKIFEFQEIIAQCRFLTSAGFDTTANTLAYLLYLLSKHYDVQENLRSEIDNEKNINFDTISQMPYLQCVVAETLRLFPHAAMLQSRRCMQDCLIGDYKFAKDLSIIFDTWSLHYDVDIWGDDANDRFGRNRTRNESLSWMPFGMGARQCVGMRFALLEIKATVCYLLKRFYIRTTNCCNVSRIVFTVKCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SSR8</accession>
    <name>A0A3P7SSR8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(S)-3-amino-2-methylpropionate transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SSR8"/>
    <dbReference type="STRING" id="318479.A0A3P7SSR8"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000073">
        <property type="entry name" value="Probable 4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49492" checksum="CD7EB7C9905D734D" modified="2019-02-13" version="1">MQKNVEAVAPSVSTPIPGPISKKLKEKMEPHHQAPSVRFFVDYEKSFGNYLVDADGNTLLDVYMQISSLSLGAVSRPALGSFPPTFYPDAITNALSSVAPRGCPGVQTMLCGTSSNENAIKAAFIWYQYNKRGKKPPTDKDLKSCMKQELPGTPNLTVLSFQGAFHGRSLAALSLTRSKSIHKVDIPAFNWPVANFPRYKYPLAKNIQYNERQDDECLAMVEKLIIDHKKAERDVAALIVEPIQAEGGDHHGSPAFFQGLRNITGKHGVVFIVDEVQTGGGGTGSFWAHELWNLIDPPDLVVFAKKFMTCGYFYAEHLSCKEPYRIYNTWMGEPTKVVLLEKAIEIIRRDNLLEQVRIVGKALYNGLLQIENVNSSKMMNVRGLGTFCAFDLLSSKMRDEFLETAVANGLHIGGCGDAGVRLRPALIFGEKHLEIALDVINKSMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7STL6</accession>
    <name>A0A3P7STL6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7STL6"/>
    <dbReference type="STRING" id="318479.A0A3P7STL6"/>
    <dbReference type="OrthoDB" id="5840876at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22684" checksum="AEEC7C966E053389" modified="2019-02-13" version="1">MLSHGIMLNARDKNGAKALHVTAIAANCFSQFQSEELRILTRMIWPLELLAVLLSPNSPLATICFLISRGANPYITDNSGRSILDIFNDKLSLKSLVELQISKRCPLCCEYITTVKVFDGRKIAIGKDIAVKTSKNSKLENTVEVGCEKKRQDSKICFNIVFQCGHAVCADCSREAQLKICHICRQKIKKRTTLYIWTESGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0M5</accession>
    <name>A0A0N4U0M5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS4471</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0M5"/>
    <dbReference type="STRING" id="318479.A0A0N4U0M5"/>
    <dbReference type="WBParaSite" id="DME_0000011101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000011101-mRNA-1"/>
        <property type="gene ID" value="DME_0000011101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF111">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="995"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1078"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1140"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1169"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1193"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1221"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="18">
        <location>
            <begin position="38"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="19">
        <location>
            <begin position="686"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN54498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000011101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1346" mass="154951" checksum="6E7E12DBDB3AB33B" modified="2016-06-08" version="2">MAGLTKWINLEEGTIMRSERLLRNSFDLTAVCANYEKYVEHASANRSSDEEFRIILPPPNVTGILHLGHALTVTIQDALCRYHRIYGRKAVWIPGFDHAGIATQVVVEKQLWKERKLRRHQISKEEFLSLCDKWKNDHISAMKIQLKMLGATLDWSRQYFTMDEKFGKAVNHAFCQLYNDGLIFRDRRIVNWCPTLKSTISDQEVDTINLSNVQSIEIPSVTSNQRRLRVGVMHLIRYRVVGCVGNKNWIEVATARPETVFADVALAVHPNDERHSYLIGKYVYHPLFPDRILPIIGDEAVLPNKGTGLLKITPAHSFTDFEIAKRNSDVIDKESFNYCCINDNGTLKNAAEFDGINRFDARDMVLNRLAELGLYGGEIHLSGFNIKLCSRTGDVIEPMIKEQWFMHCDQINDDILRALSEQKVNISPIFFQSHLEEWLNRREPWCLSRQLDWGHRIPAYRIDKESDWIVAPTKEEAALKLVKKQFSNGKEFSLKQEKDVLDTWFASSLIPLVSFGWPENSMFKPLSLLETGHDILGFWVARILVGRFPFENIILHGLIRDSSGKKMSKSRGNVIDPNDVINGISLDKMVERLNHSVLSNSEKEFAEAELRSQFPYGIEKCGPDALRFALLRHNVTGLEVNVDIVEKSKEGLRFCNKLWNLCLYAEKVWFLAPQVTNTKGLSLLTDKWIKSRLATTFNAVRCSLSSAPHLAFSAVYTFILSDLCDETTKKALWTKDEQRLCEIGQVLREVVEKSLLLLSLFMPFVSEFLFDHIKTHQKLLHESFVFKVSTIGCLEGNEVDGCVDMKLESNMAVALAVVKAIRSIRDEFEFSKNERLKVAVFMDECSITDLNDVIVDLCNASIAYQRPFRTDISNGLLPVAVVGYKATLGIIVKKNAAEKLKQKRIKIMNFVYNTEWLILIVMLVHLIIAPFTKVEESFNIQAVHDILYHRFNISNYDHLQFPGVVPRTFAGAIAISSVILPFIKLFEWYEISKYWVLLAVRLVLGCIVLLSFCNFTRSVQKHFGCETACFLRLIVASQFHFLFYSSRSLPNTFALIGVLFVYQLWLDNDLLRAVQVATVFTVVFRCELILLFGTVFIVPVLRITVPIDSLLWSRFLWPEGEVAWFNIILNKSHEYGVLPFFWYFYSVLPRALITSLIFVPLGMIIERRLFKYVLPIISYIILYSFLPHKELRFIIYTFPILNLAAAIFCARLWVNRNKNWFRYLISLGVIFHLVANSLVTAMFLYASAYNYPGGDALGYLQFMQRFDRNKPVTVYIDNFSAQTGVNRFLHLYEKWEYNKTENLTIDDLKRFDFLLLGTYSQKSIIETVKSNFSSSHRLLYTVKAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0W3</accession>
    <name>A0A0N4U0W3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4569</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0W3"/>
    <dbReference type="STRING" id="318479.A0A0N4U0W3"/>
    <dbReference type="WBParaSite" id="DME_0000020901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000020901-mRNA-1"/>
        <property type="gene ID" value="DME_0000020901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF245">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000020901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22328" checksum="E840EB597CBAC4AB" modified="2015-12-09" version="1">MEWKRRGTADGFSSINLVFPCLMMACWLKHGYMTSDNTNMFINATNLFFFTGYIAAFAFYQPKRKYLIAQLLALFISLFMIFNFVNSQPPELATDSMGSIAAAMQIVSLSGQIYEIKRAITFGHTEYIPAELQFGFFLLLTQWTIFGVLVRNYYIAVANLTALLVNIFTISLYFIYPPLTWRVPIIGTGPQNAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1A6</accession>
    <name>A0A0N4U1A6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1A6"/>
    <dbReference type="WBParaSite" id="DME_0000037501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000037501-mRNA-1"/>
        <property type="gene ID" value="DME_0000037501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10593788at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000037501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12411" checksum="1FC76089098F3891" modified="2015-12-09" version="1">MIQDLMESLSSLCSPRPELYAAWTIRMIKGKEASKIDVKDLTKFVCCILSILDEARNFRASSSHRQFLPSVERIVNYVKKIDPVECLLTLPVEVVKQLFDIAHNLSSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1H3</accession>
    <name>A0A0N4U1H3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="13">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4817</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1H3"/>
    <dbReference type="STRING" id="318479.A0A0N4U1H3"/>
    <dbReference type="WBParaSite" id="DME_0000045701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000045701-mRNA-1"/>
        <property type="gene ID" value="DME_0000045701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000045701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10751" checksum="DF9C8BB35D6C7084" modified="2015-12-09" version="1">MAGRGGKVQKVMIQPINLIFRYLQNRSRIQIWLYEDISNRIEGYIIGFDEYMNIVLDEAEEVNIKTQHRNKVGRIMLKGDNITLIQGIELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1Q5</accession>
    <name>A0A0N4U1Q5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4911</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1Q5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1Q5"/>
    <dbReference type="WBParaSite" id="DME_0000055101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000055101-mRNA-1"/>
        <property type="gene ID" value="DME_0000055101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010754">
        <property type="term" value="P:negative regulation of cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010446">
        <property type="term" value="P:response to alkaline pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="359"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="438"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000055101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="729" mass="83123" checksum="1616607696873960" modified="2015-12-09" version="1">MEKSATKNQRERGQMTSIERLVDRSKDSNEIEKLTRPSLSLAVNSPSSSVISEISQLDRQSLLIKAVTTSRLFVSLPNGTTITTKATAISPDQIELNSCDISLSELSDEGGTRKQKSSQFLEFKKTFTASPDCVSSDICQRLFSLSEDMNLLVRNITKEAKTLVHAETCSLFLLDKENSELVAEVFEKNGTSDEYLTEIRMPISLGIVGHVAQTGQMMNVKDVYNHPYFYPKVDERTGFVTRNILCFPIKDSSGNLVGVAELCNKIGKPSFTSHDEQIAATFSVYCAISISHCLLYRKLQEAHRRSHMAAELLVQGSTLSVTFIIICKCIVNAIILFFKCFSLFFILFFYLIISLILIAAEDILRLTGRDIPTTTSFHPDFTKFCFPPRSIGTGDTYIEASLSIFNELGFIDRFRLRRQTLARFLLMVQKGYRDVPYHNWSHAFSVSHFCYLLIRTNFVQKALNELERLSLFVACLCHDIDHRGTTNAFQLQSKTPLAQLYSSEGSVLERHHFAQTVSILSMEECNIFDQLTRHQYQLVLDNIREIILATDIAAHLRKVDRIRQMVEDGYDCTSANHHYLLICLLMTASDLSDQTKDFKNSKAIAENIYKEFFSQGDLEKQMGNRPIEMMDRDRACVPKIQLEFMDTVALPVFDYLSRILPEAQCTYDSILLNRKCWQALDQILKEEETPTIGLEYLRNSVLEEKVMQRIAENETFLVRFNLSCLKKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U221</accession>
    <name>A0A0N4U221_DRAME</name>
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        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5054</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U221"/>
    <dbReference type="WBParaSite" id="DME_0000069401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000069401-mRNA-1"/>
        <property type="gene ID" value="DME_0000069401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000069401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12631" checksum="CDC8296225FFD829" modified="2015-12-09" version="1">MKHYVNTDRYSLFILDSEHEKLRAAIASRYGLSAIFIEFPKYLMDINVIHIGICHIGIYHIGICHIGIYHIGICHIGIYHIGIYHIGIYHIGIYHMSFSIHPHHSIASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U253</accession>
    <name>A0A0N4U253_DRAME</name>
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        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DME_LOCUS5088</name>
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    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="DME_0000072801-mRNA-1"/>
        <property type="gene ID" value="DME_0000072801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000072801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12351" checksum="2F698DEB1883D9B8" modified="2015-12-09" version="1">MMRSKHYHRADVILGKCETTPALVESIQFHGIENTKNDALVKEIAPIYKSANVAELIHNCNLAAKHMQEIGLLDEATALVDASSDNPHGYIVNFLVKEPRPYSLGMKVYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2A7</accession>
    <name>A0A0N4U2A7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Foie-gras_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5158</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4U2A7"/>
    <dbReference type="WBParaSite" id="DME_0000079801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000079801-mRNA-1"/>
        <property type="gene ID" value="DME_0000079801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="1">
        <location>
            <begin position="92"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000079801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46337" checksum="2FB348F08F1E82F4" modified="2015-12-09" version="1">FENRDVLFKKKFFSFYRLETAFYDLAQGFYQQCLKNIRARSIPNSFINLIVRQQFKLAFLCELKQDTHTALRHYKNAYHHCTEAEVSNNDLFEIRLVSGLISFKICQLSFLHNSALDAIWQQQRHISTFFNSASGSYPSPQLAIIEHNLWKSKQCAKFAELFERAVSSGLAAVSTQHPGLHWHAAADYYRIANVYISTLWSMQGNYSFSYPDPDPLSSLQPFIFYGQRPWRAGIEDGSLASEAVEKNAQLALMLRYIPDHTQCIAWLTSALNHYKKYKCQRTQRYIMVLMADEYASLNQHVKALQLLSHMLSECRIERFFMPLATLLTKSLNYSFIIADVKEFMSVSIQMMNIRNFPCFTGVADEIISNFNLVRAGQPPNSLSIMTISQDQVKLLFNQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Q7</accession>
    <name>A0A0N4U2Q7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5338</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Q7"/>
    <dbReference type="WBParaSite" id="DME_0000097801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000097801-mRNA-1"/>
        <property type="gene ID" value="DME_0000097801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000097801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39229" checksum="7394197414D443A8" modified="2015-12-09" version="1">MEKGLGNVVENSPRKSGFRILRLGDAKVRVSESRFIPMSSYIKRRLTQEKGLFATQIFLDDLAKLNFHFSYIGLTIAKEYSDGQSVFDVKNLIDALAVANALEMEEMLEALTEQLLILASNVDSVLLAIDIAALNLRNKYCEKVIQSLERGDSKSETALTILRAILMWLKDKKHEKEKMYRIINEILPYSDENLCNHLKLIFDANITNMIDSQRICETHSASESIYFHEYQKMQEVLSSAKLETVDQPVKKLETEQTENIHNMDDNSLVKQKSEKSKKEEEVKDATENNLDAQSFPEFVLNALQIPIPLQIPIIDEYGVYNYKIEIELERKESQISKAQKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U392</accession>
    <name>A0A0N4U392_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5549</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U392"/>
    <dbReference type="WBParaSite" id="DME_0000118901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000118901-mRNA-1"/>
        <property type="gene ID" value="DME_0000118901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039478" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000118901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16293" checksum="FCF7F36A5DC1BC7D" modified="2015-12-09" version="1">MFALYIIVLFLLKSHTEAWVCGSNARLLFFCYNPFNGFCMKCVCDNGYTLIADLCTNRNDPYYRMQKDLELERFRIRIELMGKENPNITIVPHIICPSNMVLVEHICPPSENWGPNCHLICKCRDGLRKIGDNCVIERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3M3</accession>
    <name>A0A0N4U3M3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5692</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3M3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3M3"/>
    <dbReference type="WBParaSite" id="DME_0000133201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000133201-mRNA-1"/>
        <property type="gene ID" value="DME_0000133201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000133201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15779" checksum="19CA66D1E609B06D" modified="2015-12-09" version="1">MRPNQAGFRPRRYCADQIFTLRRVLEHRFRYLQLTCFIDFAAPFDSIDRAVLWRVMERGGVPEKIIRLIKAFYERTSAQVCIYGELTDSFEIRTDVCQGCTLSPTIFNHAIDWIMDIACRHSRGVRISPEHHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3V3</accession>
    <name>A0A0N4U3V3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5782</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3V3"/>
    <dbReference type="STRING" id="318479.A0A0N4U3V3"/>
    <dbReference type="WBParaSite" id="DME_0000142201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000142201-mRNA-1"/>
        <property type="gene ID" value="DME_0000142201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864015at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000142201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25096" checksum="4BDE041E52D2CA6E" modified="2015-12-09" version="1">MEKTEVESQKLQPLINLPKLQLMKFDGSIRSWVAFKDNFLSTIGNRNLDPVDKLRYLISCLEGEAKELVEGFPMDDESYRNLWEILENRYGDKSIIIEELYKELRELNPKTKDIKEIRKDLERIFRQLISLGEDINNNSILSMAQAKLPIFVLKRVLEEKRKCSTWDISESRNVMKTCEEEKLLLSRMISSGDKEKLQKHKTINNFKKENRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U516</accession>
    <name>A0A0N4U516_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6277</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U516"/>
    <dbReference type="WBParaSite" id="DME_0000191701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000191701-mRNA-1"/>
        <property type="gene ID" value="DME_0000191701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000191701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7573" checksum="057FE25220AEDB29" modified="2015-12-09" version="1">MKTFLANAFAVGRLATVQEFHLSRSGKLASHLTRPIKVTQGKHRLAYDHSSHPINGPCRQAGFQLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5A8</accession>
    <name>A0A0N4U5A8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6381</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5A8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5A8"/>
    <dbReference type="WBParaSite" id="DME_0000202101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000202101-mRNA-1"/>
        <property type="gene ID" value="DME_0000202101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="59"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000202101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42602" checksum="0864331CF11C8CD0" modified="2015-12-09" version="1">MANLNKFLEKLNLSFKMSTIHTNNTLIGSLLKCADFYTVTFAVFICIITVTMIIATLVGNALVIIAVLIVRKLKQPCNLLLVSLAVSDFCVGLIVMPIAVIDIFYENWILGEIICRLWTSADLTLCTASIINLCMISVDRYCAVSRPLRYATQRTTRRILSYIAIVWIVALIVSISPIVIWPAKHIEGTCQVNQNPVYQIYATIIAFYAPTLIMIILYAKMWLAAKRLTDQDRNFIKAMPNTANGKKPKKKQRPLNLLQKIRFVNNVWTPEKTEGKARKTLGVIMSVFIFCWVPFFLIALFKPHGLSPPGWLDTLTLWLGYSNSLLNPLIYCKYNKDFRIPFREMLCCRFRTLHSVMRKESFKSKYGPVRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5W4</accession>
    <name>A0A0N4U5W4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eyes absent homolog</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6631</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5W4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5W4"/>
    <dbReference type="WBParaSite" id="DME_0000227101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000227101-mRNA-1"/>
        <property type="gene ID" value="DME_0000227101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167668at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF16">
        <property type="entry name" value="DEVELOPMENTAL PROTEIN EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000227101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="55907" checksum="E076A3D3F30CCB67" modified="2015-12-09" version="1">MYVNVMIQGQFRSRKLPVYTYEHAFNSPFDPERNSAFRGSGSDLQRNSHIEQFACFNGPSAWSIIPDETKQDLLMPSLSDRSAAISAMTDAAATAAAVASCDARMIGAPAYYNTGYSAANYGMYAAGTSNYYPVPSTLRATATHFPFAAPPHPYYGNGYSTAGFEYAPYPTSIQCYGSRNTYYAHPINSVTSSSSLYTMSSLSAEAMTSIKGMRKKKTVGASFSPDDHYTRVFIWEMEDVCVLSNFFLRSGDPLRSHRLANSVNASVNSFIALAFGIENTDDCDQMNIEDTTIDEPINDMPFIQNSSETSVINQASTSTHLAQSVARGGVDWMRRLAVKYQHIKDIYTLYRNNYTGLIERNGITSERAELLAFKNTIDPLTQGWTDSIGRCLKLIVERSSRNQYANILITSESIVPTLAKLLISEQSSMIPAENVYSTLRMSKESVIDRILSRFGKKCSFVIISTHLDTHEIAKKENIPLWKIKSVRDLELFHIALTHHLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U671</accession>
    <name>A0A0N4U671_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6759</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U671"/>
    <dbReference type="STRING" id="318479.A0A0N4U671"/>
    <dbReference type="WBParaSite" id="DME_0000239901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000239901-mRNA-1"/>
        <property type="gene ID" value="DME_0000239901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000239901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14092" checksum="723FBE2487C59AD3" modified="2015-12-09" version="1">MSVSGTDFDSSSKQLNYGGCEGPSAMYVKLISSDNHEFIIKKDFAMISGTIKAMLSGPGTFAENESNEVHFKEIPLVEFSRSHVLQKVCQYFAYKVRYTNSTTEIPEFSIAPEVALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7N5</accession>
    <name>A0A0N4U7N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1115 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7164</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7N5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7N5"/>
    <dbReference type="WBParaSite" id="DME_0000300501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000300501-mRNA-1"/>
        <property type="gene ID" value="DME_0000300501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000300501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29918" checksum="6616F2A58F86D179" modified="2015-12-09" version="1">MDDNKDHCALLLLDEIKLLKSMYNTNELKFAENEDGIHNFYFQKIDDINIEIVIQFNDGYPLLFKPSVYIRSPSVDSFNFNKNLREYIDKCPIGQPLANDIIFWVQDNIHRYKQLPDQLSEKKPTDDTKGIYSRLWIYSHHLYSNVKRRNIEKKAKDLDLNGLSCPGKPGVIIIEGQQEKCQEFWDEIRSWSWRRIVLRHSEESTDPANFIRLRKFHELYIESKDGRTSDMSILKNTLADVNLEYGFKFLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7S8</accession>
    <name>A0A0N4U7S8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS7215</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7S8"/>
    <dbReference type="STRING" id="318479.A0A0N4U7S8"/>
    <dbReference type="WBParaSite" id="DME_0000305601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000305601-mRNA-1"/>
        <property type="gene ID" value="DME_0000305601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="131"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN57242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000305601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44833" checksum="DE4F88E945FA18E8" modified="2015-12-09" version="1">MSLLAQFCRQTHTERLEYCDGFISETQEYFFERSGRIFELVYDFLTTGHFHRQGEICHERLIKELDFWRIKKSFFAPCCMPLIDVSEDEEDGQNYIKSIEYGDQFEGVCWAAQRRKLWAFMEDPSTGTLAKAFAIISITMVMASVTGMILGSLPEFQTITHQDETNGRKETVFRTHSGLEYLELVCVIWFTVEYFARFLVCTTKNRFIREPLNVIDSHTVYFDIFKGLGAHTIGEFRGLAMVMRVVRIMRVARIFKLARYSSGLKSFGVTVKTSLAELSMLFLFLLTAIIFFSTLMYFAERDEPNTKFRSIAHAGWWCIVTMTTVGYGDYCPQTFAGKVIASFASISGVLVLAFPITMIVENFSRTYDTEKSEFKTVQRRRRLAKIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8F8</accession>
    <name>A0A0N4U8F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8F8"/>
    <dbReference type="WBParaSite" id="DME_0000332601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000332601-mRNA-1"/>
        <property type="gene ID" value="DME_0000332601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000332601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9967" checksum="94C8D16060C86D2C" modified="2015-12-09" version="1">MTSTMGKYGIGEQCANREHLLRYAEELELFVTKICFRHCRKHLIIPRIFWDSPDSQHFNQIDYILVTSSLKSSPPDSRIATLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Z5</accession>
    <name>A0A0N4U8Z5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7540</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Z5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Z5"/>
    <dbReference type="WBParaSite" id="DME_0000353501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000353501-mRNA-1"/>
        <property type="gene ID" value="DME_0000353501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872263at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000353501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41799" checksum="2987DD4C2A86BC56" modified="2015-12-09" version="1">MNCADGMSNEPPAPVFHILSGPISSLCSCLGIIGNVQLLRLLQSKAANEFSCLFTASVSALAIADIILLISSLFGYSIPLCYSYFGLNYGINYSVLIAHIVACASNTAAIWLVTLITIQRYRAIAKPFLMMQMRTLSIPSPRRSAISLSALSNFSYEKSFRYCRWPILVSILAAILNIPLFFELTITNCSNDSKIIIQTPLRYHIIYKILYRAIFKSLFETIGPFIAVLIITILTQSLIQQNRNARTELMNKTSKYKREETSLKPFTYVAVTMRNYDVILSYYSVVIAVKFLLFHFLVPALDLWEALLPLNIGLFNNAVAISNFLVLIDACTNCLIYLRWKFVKMGIKCCIMQKEENSIADQKRSFISTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U922</accession>
    <name>A0A0N4U922_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7569</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U922"/>
    <dbReference type="STRING" id="318479.A0A0N4U922"/>
    <dbReference type="WBParaSite" id="DME_0000356401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000356401-mRNA-1"/>
        <property type="gene ID" value="DME_0000356401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6070751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000356401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26990" checksum="875F3ADC7C0C9CE6" modified="2015-12-09" version="1">MGPIMTGLIPFSSVNCTLLDELVASPSSTRKTGEQQVRIFVKQLLNALKCMHDKKIAHLDLRPEVILLQDDHLRLADFGRSRPLTKGKVTTDITGSPEFLSPEIASGASATLASDLWSVGTLVYILLSGISPFLGDNDNQTLRKVILGKYLLDCDEFSKVSSEAKDFISRLLILNPKGRLTVDEALMHPWISDDQLSEAKLTSECLREFKYRHKWHERRVFVQQTPSELTLNAAQVRNLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U992</accession>
    <name>A0A0N4U992_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF645 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7647</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U992"/>
    <dbReference type="WBParaSite" id="DME_0000364201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000364201-mRNA-1"/>
        <property type="gene ID" value="DME_0000364201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000364201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7829" checksum="3F4C3F1A44F33EB0" modified="2015-12-09" version="1">MKLVNDQVAELFWCSWSSFPREVSQRRGVVTRPKGLRFDPGISVCLTDLSSAIVLPLTQRIRSDFAMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9C1</accession>
    <name>A0A0N4U9C1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7677</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9C1"/>
    <dbReference type="WBParaSite" id="DME_0000367201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000367201-mRNA-1"/>
        <property type="gene ID" value="DME_0000367201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914193at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000367201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="696" mass="79465" checksum="B533EF215C994FBD" modified="2015-12-09" version="1">MKADRLSQFFTEFTLFIRVIVPYSYLKKNSLISTMNEKVKPFAYTYGEYDGRHQSTLVSDMIGCQLGRARLTLWHYRTGYASSVDICWRQPPGDARPQGIKCFPIVSGNHIRQWLFSTIELPPISTIFELLIRITFIQPFDIVAIDDIVFNSTLCGMDPSEKNTKNQMTTLCRDPREKIFYSMCDRSNFFTDSRTKRDTVEHNPPPIIDYDDWTILRISSPNLNRPTMIVVAEAPGIKSITNNSKNDSGKKISEISDNKYVSRNEYLPTAQKYLLNSTVNSITISNNAARIASLLGENDDLELTEKKSLILSNSPIMPVISKPIRDYRQLSTDANVDGAVSAFSPSKLQQNTFPHPTDLVTNIVNIINRIAPVLPAFVHVLRSTKLSSEASTMKSFENPLRNLLLSSNRKFHPVAHHLNIPSYSSRDSILSNAFNFENNTDTAVTASKSNKSGEYPLIKSLKLRKLQTNSFGIERTIKLHQITRTNHFSHLSNKDIKMRYENKKAVSEQQQQSAAVSSEAITHIQHSKDPGPKLQELFANKIYPISEKYTNIKTFNKPILHTINSQAINVLSSGEIRKIKEIHKKLFNIQNERKKLHENHTSRVKEVLLANQPKFIIEKRDIDAFLNSEDSERIQNVLNQLPKDVVEDLQMLKTIPNPKELLDGLDLNLMNENNGFDQLKKQIIDRFLRRKIGLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9G1</accession>
    <name>A0A0N4U9G1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS7726</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9G1"/>
    <dbReference type="STRING" id="318479.A0A0N4U9G1"/>
    <dbReference type="WBParaSite" id="DME_0000372101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000372101-mRNA-1"/>
        <property type="gene ID" value="DME_0000372101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF32">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="204"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN57753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000372101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49502" checksum="F1E5C545109F2FCC" modified="2015-12-09" version="1">MTLSNEVFEILRSVLQNISEAMEKEFIIGLEKGSPESSIAMLPSYIPALPDGTEIGQYISIDLSGKNLRLMLLKLKGGLGEPEQVNHNYIVPSVVMKGTGEQLFTFIVNCLTKFLREVDLLEACLPVGFVFSYPCELLSIRCARLLWWTKGFDIKDCLQKDVVRLLEDALEMNMLTNVKIKAVMNDTVGQLAAASYKHGPLCTIGVVIGYGCNSSYLEDSKNIKKINLNAAGYKHDKMIVVTEWEEFGAKGELNCIFNKFDRQVDAASVHRGRQLIDKLIGALYLGELVRHVLAELVQNGLLFNGMVCEKIHTPDSFPTKYISEILRDDEEGHKVCRRICDELDVPSHCTKDYEIMWEVCHVVSQRSASIAAAAIAALLRHLKQENMKIGVGGALIQFHPTFFEMLNDKLKDLAPESVHWELVAADEGSAKGAAIIAAVVEKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9K1</accession>
    <name>A0A0N4U9K1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7777</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9K1"/>
    <dbReference type="STRING" id="318479.A0A0N4U9K1"/>
    <dbReference type="WBParaSite" id="DME_0000377201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000377201-mRNA-1"/>
        <property type="gene ID" value="DME_0000377201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="52"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000377201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40301" checksum="165F5A25EB15DD32" modified="2015-12-09" version="1">MRFLICCSNLRRSKREERYYAKEEVPKYSWQDFSKKFCLSDHYFNFLDFLILQDREGPPDANKYQFTGLHGEIVAKLDGHISGQQFVIDGLLPFTNTKICFQDCCILILDYTAAVVIDDCEHCLIVLGPCKGSVFVRNSSKCSIFSACQQFRTRDSINMDIFLFCTTKPIIESSKAMRFHPLFLSYEQLQEHMLKASLSPFTNNWDKVHDFTPNTGENFEICSIDYGNIEQMNLVENLEKVKFTKELSLFPEYVNCKEFIEKPLLILCKQRSNESLESLFHRSLNLIRRLVSNGVKIVSRLIAIEVGCNRISIISSLSSEDNIEIIDEGDYECYISNLHRLAEIEMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA70</accession>
    <name>A0A0N4UA70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BCL7-like protein C28H8.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS391</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA70"/>
    <dbReference type="STRING" id="318479.A0A0N4UA70"/>
    <dbReference type="WBParaSite" id="DME_0000402701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000402701-mRNA-1"/>
        <property type="gene ID" value="DME_0000402701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5989898at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000402701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16781" checksum="8E36B31363A4CD00" modified="2015-12-09" version="1">MYARNQRAETRNRAKDELKRVINSLDKVRKWEKKWIILKDTQIKMYKWMPVTAGANIPKASAKSTIVVEENNTALSGENTRDSTTLENSNVSRIRNFENLNDDSNLGFSEGGFDSDSNQTLEPTSYSHNAGSTDFSAMRQQEMAPNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAB7</accession>
    <name>A0A0N4UAB7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS446</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAB7"/>
    <dbReference type="WBParaSite" id="DME_0000408201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000408201-mRNA-1"/>
        <property type="gene ID" value="DME_0000408201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870934at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000408201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21099" checksum="952F58F1F20D46EF" modified="2015-12-09" version="1">MYSIIIYVLPSYLPDALINICFASLAIPINIYILYLICKNHGQIKGSSKLLLIEMVACYLYAAIGITSLDLFYLISLCFKIPHTIFSCSLLRRIFGMTLYAPNLGIFVVAVDRYATVIWRRHISRKIMVAAFVFPIIALSGDENCMSDKKLHSDVHAGAGRFLVIFEECIAKDVPRLPYHLGTSTKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAM7</accession>
    <name>A0A0N4UAM7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8098</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAM7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAM7"/>
    <dbReference type="WBParaSite" id="DME_0000421501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000421501-mRNA-1"/>
        <property type="gene ID" value="DME_0000421501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000421501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20574" checksum="4B0E923B984DB5D5" modified="2015-12-09" version="1">MDLQPVYYEKQEFVETATGNKVNKKSRLFGSQNIVLNGKSILMKDCILRGDMNSIRAGKYCVVGERTVIRPSYKRFSKGLTFFPVHIGDHVFIENDCIIMAAQIGAFVHIGSGAIVGRSVIIKDCVQVLPNAFVPHDAVIPPFSIVSGNPGTIIGELPESTQNLMTQATRSFYDNFVCFSKNPSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAR0</accession>
    <name>A0A0N4UAR0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8134</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAR0"/>
    <dbReference type="STRING" id="318479.A0A0N4UAR0"/>
    <dbReference type="WBParaSite" id="DME_0000425101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000425101-mRNA-1"/>
        <property type="gene ID" value="DME_0000425101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000425101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23569" checksum="86F19F63C1DD3831" modified="2015-12-09" version="1">MHFFEGHCRCQDRFEGVFCEREPCLNGGRRAKGFLNNKCYCPYGLTGERCEKVTHCIEGKGTLIDGKCRCEDRWSGLFCHLRTCYNGVTVGGGDETFCLCDIGYTGPFCDSPIVCIHGTITSENRCICEERWDGNDCNKCAANYQYENGLCKSVVTETSLIINGKKSVILWPLIAVGVGAIALIVLSAFVFVYFIKNHHAKSSLPNSESGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB79</accession>
    <name>A0A0N4UB79_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 9">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8326</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 9">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8 9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 9"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB79"/>
    <dbReference type="STRING" id="318479.A0A0N4UB79"/>
    <dbReference type="WBParaSite" id="DME_0000444301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000444301-mRNA-1"/>
        <property type="gene ID" value="DME_0000444301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="193"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="224"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000444301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48187" checksum="8D224AC89ABA7656" modified="2015-12-09" version="1">MSDVKPPFRIADIKLAEFGRKEIKLAEEEMPGLMAMRAKYGPKKPLKGARIAGCLHMTIQTAVLIETLIELGAEVQWSSCNIFSTQDHAAAAIAATGVPVYAWKGETEDEYEWCIEQTLVFKDGKPLNMILDDGGDLTNFVHERYPQYLDGIYGLSEETTTGVHNLVRMHSKGKLKIPAINVNDSVTKSKFDNLYGIRESLPDGIKRATDIMVAGKVAVVCGFGDVGKGSAASLRAFGARVIVTEIDPINALQAAMEGYEVKRLEDVAKIAQIVVTTTGCKDVVRGEHMTEFPNDCIVCNVGHFDVEIDVKWLNSNAVSSDSIKPQVDRYLLKNGRHIILLAEGRLCNLGCATGHPSFVMSNSFTNQVLAQIDLFTKHGTPQQYKIGVHVLPKTLDEEVARLHLDKLGVQLTRLTEDQANYLGIPVDGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBA5</accession>
    <name>A0A0N4UBA5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8357</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
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            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBA5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBA5"/>
    <dbReference type="WBParaSite" id="DME_0000447401-mRNA-1">
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        <property type="gene ID" value="DME_0000447401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
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        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000447401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="27118" checksum="DBD08A5F318C1D74" modified="2015-12-09" version="1">MALFIKGNHFINIYVEKVSVLYIENFFIQGSLVEKSHFLAETLFERNKIVFRANVLKILMVLVMLSCSIILSKFWYSFWIMGNNVNYFIRCCPIIYVEANDYFLILVVNFSKSKICNFENLILVELRDFEVLFKYLNSMVVVLPSRLLLNFFYSNDSLLAFNRVQYDTNYEAFMSYILVWVQMSFWAYVVFSRFLRFLNVVPFYGYELVLWYIYDMMSSIKAILKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBC1</accession>
    <name>A0A0N4UBC1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sulfite oxidase</fullName>
            <ecNumber evidence="6">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8374</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBC1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBC1"/>
    <dbReference type="WBParaSite" id="DME_0000449101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000449101-mRNA-1"/>
        <property type="gene ID" value="DME_0000449101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000449101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61478" checksum="DBFDB67F4AF7396E" modified="2016-06-08" version="2">MRYKPVGQQTEPKPEMIPLEVRIISGKNYTKTTVAIIGSLTFGGVFLKTAFAKISSDISDISDIADNVDNQQLKIPERNDLPVYRLDDVKKHGRNAQRIWLTYQGGVYDITDFVESHPGGDKIYLAAGGAADPFWNIYEQHKTPEILEMLEEYRIGNLDPKDIVAVDEIKDENDPYRNDPKRHPALLVRSQRPFNAETSPELLLDHFITPNQIFFVRNHMPVPDINSEKHRLSISGIGIKKTIALSVNDIKRKYKPITINSSIQCAGNRRAIMGSHKKVQGLSWGGTAISSAKWTGVKLKDVLIEAGVDPNDKRIKHVKFGGCDSDTDGRTYEASLTFKKAMSDEVIIAYEMNGEDIPRDHGYPLRLIAPGIVGARQVKWLTTIILSEEESGSHWQRSDYKVLPLSVGPSDVQDFDSIPAIQEYPVQSAFCVPANEITVNRADGELDVAGYACSGGGRGIIRVEVSGDGGKTWQCAELEQDPEQDLDHMWAWTLFRTSLKIPQDVKEMNLICKATDRSYNTQPETPLGIWNIRGLNNNSWHRIKVNIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBS8</accession>
    <name>A0A0N4UBS8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8564</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBS8"/>
    <dbReference type="STRING" id="318479.A0A0N4UBS8"/>
    <dbReference type="WBParaSite" id="DME_0000468101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000468101-mRNA-1"/>
        <property type="gene ID" value="DME_0000468101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000468101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13844" checksum="5A37C3E2D926342F" modified="2015-12-09" version="1">MAYTRFKGKFCNISVISVYTPTLSADDRDKDKFYVELQLLTKSLPKHDMVIIGGDWNARVGHIADVMTSTIGKYGIGDRCANGERLRYADMLKSMNFLLLILASGIIKTSSHVELSGQPTLQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBT8</accession>
    <name>A0A0N4UBT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3752 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8575</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBT8"/>
    <dbReference type="STRING" id="318479.A0A0N4UBT8"/>
    <dbReference type="WBParaSite" id="DME_0000469201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000469201-mRNA-1"/>
        <property type="gene ID" value="DME_0000469201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="346"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000469201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52934" checksum="A66F3711D29D4A47" modified="2015-12-09" version="1">MSSPQLPRECVPLQLPSWDEIDSAEMNCSGSECESESDQSSLDSSSRDEIEDLAGPSSVASIDTEHPSLDPSHLFIDHLPNSISDNISSFGCALPPTTLYGNNGSSDDDPEDPGDPEDPDGKVFPVFSCEMLYSHGPSVLPASYSSPSRHPSSNSTTSVNLHNNFSPSLPVEETKIEHGTTLPPPEPEETRTLLRSTNIHHSKDSKFVQTSIPELPISRHFAQSFLPSNESNSKNNYESAFGPTMPLDLYPQPSASSYPNEFDVEIPIESDEHHSVGESIDNIIGPIPPWEQNSEAMAKDYEDRFARYALCKTIEINRIKLKAPIKKREEWMLKPPTKLGRIAGCSSFSRSLSGNAANDEGIRNWTETPLEKAKRLGFVDCVSFLENSGKSQKLQDPKQKPSDASAEGTSSSGNISLLELHRRKRKLDDDKPMIRRPFDRERDLQINGPISNKYSSVIKEQLEELKSRFTISRSEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCD0</accession>
    <name>A0A0N4UCD0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translationally-controlled tumor protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS539</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCD0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCD0"/>
    <dbReference type="WBParaSite" id="DME_0000491801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000491801-mRNA-1"/>
        <property type="gene ID" value="DME_0000491801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000491801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16414" checksum="C26DF69926139EC6" modified="2015-12-09" version="1">MKLIDGLVWEFKGRHVVRKEGEIVLAGANPSAEGEDADEGTDEHVERGIDFVLNHRLIVRPFFFCIYILKVLSYWLNSLGWLVAPDKYATELFGERGAGELPTSLGFLNKFIPAGNRTQHRRFELSIPQSHSIFIVYSSSNSSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCV2</accession>
    <name>A0A0N4UCV2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8915</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCV2"/>
    <dbReference type="STRING" id="318479.A0A0N4UCV2"/>
    <dbReference type="WBParaSite" id="DME_0000511601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000511601-mRNA-1"/>
        <property type="gene ID" value="DME_0000511601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826293at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053123">
        <property type="entry name" value="CPG4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37442:SF1">
        <property type="entry name" value="CHONDROITIN PROTEOGLYCAN 4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37442">
        <property type="entry name" value="F18A1.7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000511601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38612" checksum="1E42EF19CD4D5A40" modified="2015-12-09" version="1">MKAIMSYEELTDCAKSCDENDQYELKKQIGLSNYICNEKIEEFRLASECMQSQEIGIIDKCSNDCQEPANTTLQLDSTPEAPVNPFTFVENIVPICNKLECTVKCSIMELNKKCAGSGELFKDIGLKQVIDASIRLNNDAENSTSTVAAQMAKIYLQSLPKSCSFIIDPLQYDVLFTAHENEGSAMVTEVASINEFSEVTNDNEDTHTFNAEEPIFTDDIERLSTRIFDVEIESTSPKPSVASEDVVDMANFPHEIDTSPDREPEPTKSTMETSDTEAAVFKTKNEVVMTTEPNNVGASNEAERTIMVVNEDENQIVKNEVMNTDREKVSQILISADFDSLFFITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD42</accession>
    <name>A0A0N4UD42_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9022</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD42"/>
    <dbReference type="STRING" id="318479.A0A0N4UD42"/>
    <dbReference type="WBParaSite" id="DME_0000522301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000522301-mRNA-1"/>
        <property type="gene ID" value="DME_0000522301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000576">
        <property type="entry name" value="CBN-SEK-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF28">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE SEK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="45"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000522301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39041" checksum="313DC5EE18B94093" modified="2015-12-09" version="1">MFGKSKLVRLTMPQPENPPDLDLDDKCMMKLFEQSDEIEVNACDLEKLEELGRGAYGVVEKMRHKKTNFIMAVKRIHSSINDESQKRMLVELQACMKSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRMCFDSEGLNFMKEQMNLIHRDVKPSNILLNKQGAVKICDFGISGHLTNSVAKTVNAGCKPYMPPERIEGEKKVAYDVRADVWSLGITLVEIASGSHPYGKWKTPFEQLKQVVHEPPPRLSRNLGYSDNFQDFVSLCLTKDYKQRPKYPDLLEHPFLEEARNDRRFNMGVFVQEILGAAEKQRESVLHGIQIKTPENELQTLKLNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDD2</accession>
    <name>A0A0N4UDD2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS9131</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDD2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDD2"/>
    <dbReference type="WBParaSite" id="DME_0000533201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000533201-mRNA-1"/>
        <property type="gene ID" value="DME_0000533201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230592" description="Glucosylceramidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="102"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN59158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000533201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="537" mass="61927" checksum="E690B642A7AFD4B9" modified="2016-06-08" version="2">MKAILIMISTLFLFKVNSDKPCILKQYEGREKFVCVCNATYCDEIDEINDLKPFEAIIYESSESGKRFQKTTTGFTNYSKYANKSQQRRIVVNEKQKFQKIFGFGGAFTDASGINLNSLSEKTREALIRSYFSDTGLQYSLGRVPIASCDFSTHVYSYDDIADDFGLKNFSLTDEDRKLKVKLLKFKDNLEKKQMIPFIQQALNFTNGQMKIFASPWSAPFWMKSTNSMAGGGTLKVNNNESYHVTWANYFIKFIEEYKKANINIWGITVQNEPTTGVALDYKFQTMYFNPLTERDFIKKHLGPTFKKSPVAKDVKIIIMDDQRIQLPQWPDQVLRDAETEKYVSGIGVHWYLNFVSAKRLSETHNRHPNKFILATEACAGFIMPNKGPFMGDWDRAIHYTHDIIDDLANWVVGWTDWNLCLDVNGGPNWVENFVDSPIIVNATLDEFYKQPMFYAMGHFSKFVRPGSFRIESIIKDPSVPFEAIAFVTPKSQTVLIMNNPDFEQTFMLTIEDKSIKDKFLDIILKPRTLMSIVWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDK9</accession>
    <name>A0A0N4UDK9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kin17_mid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9223</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDK9"/>
    <dbReference type="STRING" id="318479.A0A0N4UDK9"/>
    <dbReference type="WBParaSite" id="DME_0000542401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000542401-mRNA-1"/>
        <property type="gene ID" value="DME_0000542401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13155">
        <property type="entry name" value="KOW_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000021">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041330">
        <property type="entry name" value="KN17_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041995">
        <property type="entry name" value="KOW_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18131">
        <property type="entry name" value="KN17_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25092">
        <property type="entry name" value="SH3_KIN17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000542401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45949" checksum="4314F5322D867EDD" modified="2015-12-09" version="1">MGKPEKGTPKEIANRCKSKGLQKLRWFCQMCRKQCRDQNGFKCHLTSESHQRQLLLFAENPNIYLKEFSIDFERNFLTVLRNTFGTKRVRANEVYQEYIRDKMHVHMNSTTWHTLTNFVLYLGSSGKCRIDHTERGWYIALIDQEEELRAEKEKNKAKAEINDAEQHMLMIEKQAERAREKAAEKEEKHHSPTEFRRDENDEKITFALPANRNFSTFFSDLHLFSWLISEIKSEVKSELSVRERENVSSTKNKIKKSALDELMEMEERKKEKQNRKDYWLHKGIIVKIMTKKLGMEFYKAKGVVTSLIDNYVSLVDVNGHLLKIDQNHLETVIPAVGRRMLIVNGAYRGLKAVLEAIEESNFAVRLRIVEGLTKGRIISVPYEDACKLSETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDU6</accession>
    <name>A0A0N4UDU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2750 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9262</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDU6"/>
    <dbReference type="WBParaSite" id="DME_0000552101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000552101-mRNA-1"/>
        <property type="gene ID" value="DME_0000552101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000552101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12553" checksum="559A4CE080FE9130" modified="2015-12-09" version="1">MEFQEKELEDKLALNQLSEVIGRLDLVAGDGQIEIMQTSSWWQYIYLGNKSSYHPCIDDLDNWLNFFQNMQYNCAVIFIDSKNDLVLEILPFVREFIRKKGEKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDX3</accession>
    <name>A0A0N4UDX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9291</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDX3"/>
    <dbReference type="STRING" id="318479.A0A0N4UDX3"/>
    <dbReference type="WBParaSite" id="DME_0000555001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000555001-mRNA-1"/>
        <property type="gene ID" value="DME_0000555001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000555001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16273" checksum="D5DADDD22A587955" modified="2015-12-09" version="1">MSVAQKAVIKNPQKLQEFYSDIREKKINSYVIFEILRDGTIVVDEKGPIRKSYAEFLERFFEISRGRDECLYAMVDVEVRPGTKKFVFLLYCGDQITRQFIVKGALLFCEMKTTFRSADLQLMAADYRDIAEDSIKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE44</accession>
    <name>A0A0N4UE44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS670</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE44"/>
    <dbReference type="STRING" id="318479.A0A0N4UE44"/>
    <dbReference type="WBParaSite" id="DME_0000562501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000562501-mRNA-1"/>
        <property type="gene ID" value="DME_0000562501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311720at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF6">
        <property type="entry name" value="TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000562501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15227" checksum="45944B72A7207732" modified="2015-12-09" version="1">ILEILSSLPLQIALYYNICIAPFWFSYLTLTYKLIVSTTCVVAILIEFIRLYLGYYGNLAEKVPALSGFWITTLVLQTPIEIFLFFSQNVIPLPLERIMYIIHLIFLFFEVIYIICILFYPQFCQNSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEQ4</accession>
    <name>A0A0N4UEQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9398</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEQ4"/>
    <dbReference type="WBParaSite" id="DME_0000587401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000587401-mRNA-1"/>
        <property type="gene ID" value="DME_0000587401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36516">
        <property type="entry name" value="PROTEIN CBG04168-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000587401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="50052" checksum="4C1F2D0568F258B6" modified="2015-12-09" version="1">MAQTCSYRRKNFVTEWKYDQLSKQMVFFFNITDPSTKFLSGIAIGDSSDSEPFVFIGVRNYKENPDTVIHHFDIHSAKKRNQNNTSTIKRKNGFIVANITQPMFSPNSENFNLSCFTIYFSKQWNIAKTGANEYNWSSSDNRTVCTNQCLLLENPPPDHLISSNEIITTEFNKCKSREQNLEVEWLYDEDENAIIFDISHQILPGKYNITIVISNKNKESDLIVLNMQDGRFMFLINYNKANNQISIRNNTRQYKILVQLAGEISHIWLSRFINDYDKTAFDKCVRLQLTLSVNEYPNSSQKYYEAVSSIICDIKQNCPKQAIHNAKKQIYLTNDTDKINEHEEAIIASEQLTTEGNGWFESSLITLDNAESVTTEHIPSDMAETTHRFRNNCGREDSMVCMKYFQLYFDKVAKWSEQNEENFEDQYQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF48</accession>
    <name>A0A0N4UF48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBA_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF48"/>
    <dbReference type="STRING" id="318479.A0A0N4UF48"/>
    <dbReference type="WBParaSite" id="DME_0000604101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000604101-mRNA-1"/>
        <property type="gene ID" value="DME_0000604101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800475at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000604101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34996" checksum="A5C4AFEC38296BFF" modified="2015-12-09" version="1">MRIFPIDENLKNYRLHKIGIRENLLYISPDRNDSIEIWSIHTFVANSWTRIIHIPLIEKLFTSFAISQQQPIIYDSMTFVIKNEQIYGKLKDDRCSRFPIVIDGDIRKILKIYDNHELVVYDGNKNCWNTYFPSPKSCINLNSLTARGIGETYGRNGHRVGAVESLLTIFIDEGICIAKIYRNNFHSFFYIKLNDEKREYVTEGASRCKLPFFIQQSNEFCRASSKTEIVQWTVCTKSQFVFICKNGIALLPLQPPTLKESAFLSIQQKYSNIIANKWFGGISEQQIKDLCFCTMERSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD1</accession>
    <name>A0A0N4UFD1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9430</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD1"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD1"/>
    <dbReference type="WBParaSite" id="DME_0000613401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000613401-mRNA-1"/>
        <property type="gene ID" value="DME_0000613401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="114"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000613401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="42397" checksum="1C842E3765771D83" modified="2015-12-09" version="1">MERTACIETGKETLIEIDKDGKGLGLSIVGGSDTVLGTVVIHEVYSDGAAAMDGRLRAGDQVLEVNNVSLRGVSHEQAISLLRRTPSKVRLLVYRDVNLQLSLLDPTQIYNIFEIELTKKPGRGLGISIVGRKNEPGVYVSEVVKGGAAEADARLMQGDQILAVNGQDVTNSMQEDVAAMLKACTGRVSLKVGRWKLTEAANRVHSASKTASSETSRNGALAIKAAAKSTLEAQTDKNIAPPCSPSSKLVIPQVAIDDASQVTSALQSDLSPVTEELNSSTDQKSLIAEEESSSTTSQSKEIELITDLREDDCDSLLIQLKKIPDQQLGMGIGKRTRGILVTSLQPGSIAAEKLKVGDRLMAVNGLPVGDQLSAVTYVKASGEKLWLQISRPRSLSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG65</accession>
    <name>A0A0N4UG65_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9577</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG65"/>
    <dbReference type="STRING" id="318479.A0A0N4UG65"/>
    <dbReference type="WBParaSite" id="DME_0000646601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000646601-mRNA-1"/>
        <property type="gene ID" value="DME_0000646601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823771at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041666" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000646601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18555" checksum="0211E266515514D9" modified="2015-12-09" version="1">MLLLVVFFFVLNALRLVHAVSGTSLTTLLNQLDDTSKCNSQIISSSLHIILQQYLQREKPNLLLLAKIITQSSRPYSVQLPKNANFVNKSPVTMNSTEPLYILQLYCNQHRQQRHTAAIWHPILIYPLETHNSFLVIKLPNIDLYACTSSNCTNSKVIINFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGF4</accession>
    <name>A0A0N4UGF4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1302</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGF4"/>
    <dbReference type="STRING" id="318479.A0A0N4UGF4"/>
    <dbReference type="WBParaSite" id="DME_0000657301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000657301-mRNA-1"/>
        <property type="gene ID" value="DME_0000657301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795386at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000657301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34582" checksum="9EA62FD69A1C7E6B" modified="2015-12-09" version="1">MVLSHGKTLVLCSHCKATSHSLWRTNVCHICMKYFYNLVEHEPSHYKDKEGSNALYECPHCYRSFARFPELKSHLVRHKKSCVKQYFKCQKCSSTFRSHHLRDQHIISHYKTIFDKIWEKFWSTQTCNKKPHCPLCSFMVTNKKSFRLHIIHRHANGFSSEKLEELLSSLMTKFQAESDILKEFIEEQDEDFINNNSSAMNISDQRIEIVMDGPNEVSANESTAVQYEEQNCSPASIREKFISACLDINTNDLPKCTKCDCIFRHMVDFELHVIRDHSSDLIYNRCYITIIRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGR7</accession>
    <name>A0A0N4UGR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9728</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGR7"/>
    <dbReference type="STRING" id="318479.A0A0N4UGR7"/>
    <dbReference type="WBParaSite" id="DME_0000670201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000670201-mRNA-1"/>
        <property type="gene ID" value="DME_0000670201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000670201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14348" checksum="F1A59487A3E04BA6" modified="2015-12-09" version="1">MKVAVWFQNRRAKHRKQEKQLSKALVPQSMFPPQTAGQIMRAPMYPPSAMSARTAADSFWYQPYPVPRPMAYPSAAQPYGAVSTSGFSNAMAGSTISSFGTDPTEDFYQKSLALRMSCRAPTTNVQYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGV5</accession>
    <name>A0A0N4UGV5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rad60-SLD_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1357</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGV5"/>
    <dbReference type="WBParaSite" id="DME_0000674301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000674301-mRNA-1"/>
        <property type="gene ID" value="DME_0000674301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000674301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8033" checksum="047EBD541DE3C08C" modified="2015-12-09" version="1">MMDWSDDEDFVNEGSGSGEESPVLAPSSREPVIVRITTKITEPWKIVKDLRFELSAEFLICRCLHYHLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGY9</accession>
    <name>A0A0N4UGY9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIP49_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGY9"/>
    <dbReference type="WBParaSite" id="DME_0000678101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000678101-mRNA-1"/>
        <property type="gene ID" value="DME_0000678101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8543887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF2">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM69 protein-kinase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000678101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37127" checksum="8D70A7260C9BBFD8" modified="2015-12-09" version="1">MKNFSAHSLLVNLCNAYKARKVNGDLCNRLCFGDDWVILHLYEGNKVVITLKLSSQEVVLKSQHATIDEFEQLDPRILDIVNYNLRLGWPSYYKKHLMEIIWPMYARKNGFLSESDRRSLWTLVSQEEYITFRMLPLSRVTPKVIGTCGHFYQVEHLVPFRMKGYYMNLKAKILVHLMGMLKLFDEFLNEPLQWCDVKFDNLALAAEYPKRFMVMDADMLYTKSRLDSILTSRHCINDTDCSFFDCESRCNTTVGFCSRRLNNNVDVMCNKLVFQLFGKFWTKSNRYLAACHDRTISTEQRLADLRLAWSWNLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGZ1</accession>
    <name>A0A0N4UGZ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7027 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1397</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGZ1"/>
    <dbReference type="WBParaSite" id="DME_0000678301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000678301-mRNA-1"/>
        <property type="gene ID" value="DME_0000678301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054291">
        <property type="entry name" value="DUF7027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22954">
        <property type="entry name" value="DUF7027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7027" evidence="2">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000678301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26060" checksum="077198F9B0147075" modified="2015-12-09" version="1">MEKVKNFWNDIAGDRIDYSQFETRDDDSDIMVFRENSQKFRLFGTGIHVNLGATVAATIGLIVTIIFCVIYTFYHNRGQGRNEFIDHLELVDLLFAFFIGLPCHYMLFYGIYKENKRYLTPFLIFYCTNFLLNVMFSTITIIATIIDARRLLYGHVQYDFGWIVFQLCFTIAQGFAIYLVLRCRKYLSAKEHWKKQTAEVKNSQIFLNHPNICDPLGSFHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHC3</accession>
    <name>A0A0N4UHC3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9777</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHC3"/>
    <dbReference type="WBParaSite" id="DME_0000694501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000694501-mRNA-1"/>
        <property type="gene ID" value="DME_0000694501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867083at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039549" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000694501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7790" checksum="D0EB1F9BC7375629" modified="2015-12-09" version="1">MRASLCYIMVNCATFELTLSLICVQSPSSIILAIKGGPTACSNDRANCAQMQRFCTVEPFAATMPKICHICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHR6</accession>
    <name>A0A0N4UHR6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS9839</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHR6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHR6"/>
    <dbReference type="WBParaSite" id="DME_0000710901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000710901-mRNA-1"/>
        <property type="gene ID" value="DME_0000710901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="496"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="689"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="1343"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN59866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000710901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2149" mass="245066" checksum="96D395AF1F3C7087" modified="2016-06-08" version="2">MADEIARVQQYEYRQNSNLVLQVDFNFTDRRGRDEPTGEVMPLTKNMLAGVKMGDKFMRMKPPQGDQKKSKKKKKNDTDLSVPNAATATLLGDSNSEMLSLYKPRTQETKQTYEAILAYIQDAIGDQPRDILCGAADEVLAVLKSEKIREKDRKKEVELLLGPLTDERIAVLMNLAKKITDFSLDEDRIQPDNQDEIDETIGVNVHFDDSDDEAEGDEAMEDVVKEEDEDDEEGGVEAVFEETLKAGLMDEEDASGNRKGVLNARDIDAHWIQRSLSKFYKDPIIAQQKVNEVLHILKEASDDRDCENQLVLLLGFDQFEFIKVLRQHRQMILYCTLLKRAQEGKEREEIEKEMLSKPELHSILTELQEVENTDIIESEREKRARAQQQRRMAGAQGRGDEATSAGNWMQSRKILDLEDLSFAHGSPFIGNKKCHLPDGSYRKQKKSYEELHVPALKPKPFGENEKLVTIAELPKFAQQAFDGYKTLNRIQSKLYESALKTDEHLLLCAPTGAGKTNVALLCILREISKHMNEDGSIRVDEFKCIYIAPMKSLVQEMVGNFSKRLAPYKIVVGEMTGDQQMNKDQFMQTQIIVCTPEKYDIVTRKGGERAYSQLVSLLIIDEIHLLHDSRGPVLEAIVVRTLRQMEQNHEECRLVGLSATLPNYQDVGTFLRVKPGHLYFFDNSFRPVPLEQLYIGITEKKALKRFQAMNEVVYDKVMEHAGKSQVLIFVHSRKETAKTAKAIRDTCLEKDTLSAFMREGSASTEILRSEASQVANADLRDLIPYGFAIHHAGMTRVDRTLVEDLFADRHLQVLVSTATLAWGVNLPAHTVIIKGTQIYNPELGRWTELGALDVMQMLGRAGRPQYDSKGKGIMITNRSELQYYLSLMNQQLPIESQLISKLPDVLNAEIVLGSINNVSDAMNWLGYTYLYLRMVKAPTLYGISHEQAKSDPLLEQRRADLVHTAAVQLEKANLIKYDRKSGFIQATELGRIASHYYCTHDTMQTYNQLLKATATEIDLFRIFSMSSEFKHIMVREEEKIELQKLAEHVPIPIKESLEESSAKVNVLLQAYISQLKLDGFALQCDMIFISQSAGRLFRALFEIVLFRGWAHLAQKVLGVCKMVNARQWQSLNPLHQFKKIPLEISRSIDKKNISFERLYDLDQHQLGELVKMPKMGKPLYKFIRQLPKLDMTAMIQPITRSTLRIELTITPDFQWDERVHGSAEGFWIFVEDVDGELILHHEYFLLKQKFCEDEHLVKMFVPVFDPLPPLYFIRIVSDRWLGSETILPISFRHLILPEKYPPPTELIDLQPLPLSALNNPQFQSIFLEKNIKVFNPIQTQVFRTVYEGNDNVFIGAPHGSGKTVCVEFAILRHFDNNPDAKAIYVTTIEDLAEKVFADWQERIGGALGKTVVILTGEPSTDLKLLQRGQLIIATPERWDNVSRRWKQRKNVQAVKLFIVDDLHMIGGNNGPVLEIICSRMRYMSSQLDSPIRIIALSSSLANARDIGQWLGCSSQATFNFAPNCRPLPLELFIQGFNLSHTASRLAAMARPVYAAIVRHGGKLQPRPALVFVPSRRHSRSTAVDMITMAHADGQPKRFLHINSQEPRFVQLVDADKTLKETLACGVGFLHEGTTAKDMTIVEQLFQSGAVQVCIVPRSMCYQISMFAYVVIIMDTQFYNGKYHVYEDYPIGDVLHMVGLANRPGIDEDAKCVLMCQTSKKDLFKKFLYEPLPVESHLDHCLHDHFNAEIVTKTIENKQDAIDYLTWTLLYRRMTQNPNYYNLQGVTHRHLSDSLSELVENTLKDLENSKCITIRNDMDTHPLNLGMIAAYYYISYTTIEVFSMSLTAKTKLRTLIEIISNASEFANMPIRYKEDIILKQLADRLSTTQKHQKFTDPHVKVNLLLNAHLSRIQLSAELNKDTEIVVLKAIRLVQACVDVLSSNGWLMPAIHAMELSQMLTQAMFTSESYMKQLPHCTSALLERCKEKKVASVFDLLDLEDDVRQDLLQMTPAQMVDVAKFCNNYPSIELEYKIETDGGDTVNVSVEMERENDLNGMAPPVVAPLFPQKRKEEGWWLVIGDHANNALFSIKRLTVHQKAKMSLDFTAQTVGRMHYKLYFICDSYLGADQEFDLKFRVEEVGRSRKRVKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI54</accession>
    <name>A0A0N4UI54_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9938</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI54"/>
    <dbReference type="STRING" id="318479.A0A0N4UI54"/>
    <dbReference type="WBParaSite" id="DME_0000727001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000727001-mRNA-1"/>
        <property type="gene ID" value="DME_0000727001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000034">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="252"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000727001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41953" checksum="21B36AD461D3D87A" modified="2015-12-09" version="1">MTTNKLEYLYLQTKSREISQQKSVNMKRKGCEQNINHRKSVLADIMADYDKTVLPSNESIEVNVELTVQDISSISEMTGSFVADVWFSQIWEDPRLAYKDISCRTNLSLDGSVSERLWTPNVCFVNSKHSEIHKSPASNVLLIIYPNGTIWLNYRVRVSGPCIFHLSYFPIDSQECMLIFESYSYNIAEVRLLWQAWDAVRMPDNNPLRLPDFQFYNVTWTKTTEDYTAGLWDQLKVTFRFKRLYGYYILQMYLPTYLSVFISWIAFWLDSRSLPARITLGVSALMALTFQFGNVVKNLPRVSFVKAVDLWFFVCVAFIFFSLVELAAVGAFDKNDYTFLPKRRRISRRAFQSRFVPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIA0</accession>
    <name>A0A0N4UIA0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAGUK p55 subfamily member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9960</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIA0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIA0"/>
    <dbReference type="WBParaSite" id="DME_0000732401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000732401-mRNA-1"/>
        <property type="gene ID" value="DME_0000732401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="282"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000732401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="54267" checksum="05F37063179C3934" modified="2015-12-09" version="1">MEAEVKKLKLNADNLAVCLHSLLKRIEQLEGSAGHDKSNGTASDINISPSKSIDEALGALLAEETESAVNGPKSDVKIICNETVSIDPDTGLKKRTKVTERILTTKTFHAIAVNDGETHDCNYISFSTNEPRFITLKSNPFNDIRYHRQDGAFFITEVKPASSYAKDLHCGDAVVEINGQPSYTIRNLNSLHGELKLKVVSIPIHQAPSIFYRAIFDYDPNNDSYIPQKWSGLALKKGEVIQVMSQDDKWMQARKVNSVDKVGLVPINFASERVAMLTPYGRRVLILLGAPGVGRRTLKSMLLSYMPQYFATVTPLTSRAPKPKEEEGREYYFRTKAEILNKIRAGEMVEWGELDNQLYGTSADTIRDCIRGGRMCVLDCAPQALRYLYNKEFMPFVVVISPPDLTDQWQINKAKPNPRTEEQLQMTIEENKLLLSSEYAKMFHLILPNRNIDITFRRLIDALNQLKSEIQWVPEVWLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIA1</accession>
    <name>A0A0N4UIA1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9961</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIA1"/>
    <dbReference type="STRING" id="318479.A0A0N4UIA1"/>
    <dbReference type="WBParaSite" id="DME_0000732501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000732501-mRNA-1"/>
        <property type="gene ID" value="DME_0000732501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF192">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000732501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33776" checksum="ECC0294CC4E3E734" modified="2015-12-09" version="1">MVESHGDKMLSFFFRFVIGMKHIAKTYQQEEATRIMRELAASYSRYNLTTFMPLWLFTDQYAIVIPNTVQNIVIALLVMIIIAILLIPQPLCSLWVALAIASIDLGVIGFMTLWGDAISMITIIMSIGFSVDYSAHITYGYVISDEILPKERVRRALAALGWPLTQGAASTILAVVVLADVPAYMIVTFFKTVFLSIALGLVHGLIFLPVMLSLFVRGSYIIGVKTSTKVGDATEKIQKNHKNIKNVAVDDDIQPYGRYAIYLSRMSSLEMPGIKSMESNVQSKPLRSQKARHVDVGSPSTNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIB5</accession>
    <name>A0A0N4UIB5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9975</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIB5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIB5"/>
    <dbReference type="WBParaSite" id="DME_0000733901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000733901-mRNA-1"/>
        <property type="gene ID" value="DME_0000733901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000733901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="22044" checksum="0AC96CFCF36E4CDA" modified="2015-12-09" version="1">MSAKSLPKIRATIGHIPQRLKMPLLPNPRGRLEILRRMVTRLIREERCEFSHNRAVEVRPYFERLIHLGIYRGFDDIYTKEMMEWWITEGDLKEKMSDVIVPRLRELDSPYTLLYRLPSLSLQSRIFKRNSYYRYYDIGVLEIKGNPFPPVILEREDYSGSLLNILLKNALKKRLDELKEISTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIG4</accession>
    <name>A0A0N4UIG4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10035</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIG4"/>
    <dbReference type="STRING" id="318479.A0A0N4UIG4"/>
    <dbReference type="WBParaSite" id="DME_0000739701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000739701-mRNA-1"/>
        <property type="gene ID" value="DME_0000739701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF4">
        <property type="entry name" value="PROTEIN LET-99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000739701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="803" mass="92045" checksum="772E5EF02D44CD5F" modified="2015-12-09" version="1">MAGNVFLKSFRSDFSIKNENEKSVDDEKQNSTFEGCFRATRMWNEILMRFHDGMPRKRHRRYLRSFDNCFTGEEAVEFLMNELPKLLSEKKDITRTNCALLLNKFINRNLMESVRDKNSAFKECDIYRFTARNKSTKASIRRANSFNERYDVKNDVGSSQALQGGPYNGEKFFQARIFIESYQPSLLKSRRLSSSHGDLPSVSVPKFCKSNESIESNRAVINFKLKDKDCIKHTNNLIGSEKDGKSRLDDVISKLAQINQSSNSSIQNQNPISSGKVVSDEDSSSTNQTINFQSSIHEYCSSKHPIVNIDRAPAVSDNIIQNSLNDVAKETKINQIGSSECLKNENFFSVHRVVRSANDLIRSPQALCSSGNLRNFGKVIQRCASPNEKIEEFRSEFKFFSKDTNEYPLVDCDVDKVWKNALLIRLKNLLQVDFLFEVFHHGFTGRDLRWNCEKVGSKGIVQVRGEEDGLSNYLLAMMRCLSRWPFDNELVDKNVIYPGFELDVFENICDHFMKELSIMPLSIALSILNVVNEIARRNRSSSRRNTKIETIFLGSNTPVRRIIDVKKKIERWSSRDTPECASTNFVRLPYYQNNVSISSPKFCAKQSNDSSLIQHFNPTNSGNSGENLTFDAIICRLPGLQTSPELIERLKELNKLSNKDKNQTNFIRNKSSYSSKAPPLGYNPLVANIRFSDIPVLIECVSLILLTIRPPLRRKLHYLIRFMQRISRNHCLRLDSNQGNRYVVLDRLSDCIIAPSEKIDHLKCLHLVTFLIDNESELFAIPKNFKIIVESELKSKKNGDVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIN4</accession>
    <name>A0A0N4UIN4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1762</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIN4"/>
    <dbReference type="STRING" id="318479.A0A0N4UIN4"/>
    <dbReference type="WBParaSite" id="DME_0000746901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000746901-mRNA-1"/>
        <property type="gene ID" value="DME_0000746901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399166at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017246">
        <property type="entry name" value="Snapin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305:SF2">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000746901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14848" checksum="2B4566DEA2872AA9" modified="2015-12-09" version="1">MSFDESLCREVCDRDDMNDSLFDIIRPVIEHLHDQIRLTRSSQYNLNQCIDNLSQRLKEIGYDECAPYDLDLFVRKLENSMARINSAESSLKDIHDRLSRLQRQIARETYQQKQRLSQIPPSPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIR5</accession>
    <name>A0A0N4UIR5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1777</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIR5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIR5"/>
    <dbReference type="WBParaSite" id="DME_0000751001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000751001-mRNA-1"/>
        <property type="gene ID" value="DME_0000751001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF4">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin" evidence="2">
        <location>
            <begin position="567"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000751001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="740" mass="81892" checksum="FEED2C2ACEFC8D68" modified="2015-12-09" version="1">MDFNTITGIIGGISNMIQNNVETIEVPASTIMGRWFQMYKAAVNFDVYRTEMFCPVAYFRPNVVMGEDGFSIEEAYRVISKNGPVETYKKDLNKVGPGQYWMYTEEYFYPRQFYIIKVGPNYSNDSSSVNSSSIYDYMVVTDASRLSLMVYARDPMKFFQNFNKEVVEYLEKAGFGGKIFWNTPRPIYQGSDCEWPSEKEVFARRVLKNQEIAQRSKNERDSELRKNAGGKGSAGIAEMLKNPQMLGVFNLPHAQRFAAKPTVPPELKKYFELDDHALGLVDSVIGPRPGGFFPPKSYEIGRSSTKNLVQTQTSNPLSEVERTLEHFLTGSDSARLPPGFNQGFSLSRGSEDILSSYSSSKKSTDNRDPSSSIRGIPNVYPDLSKPPVALRNPQFSHLIADKIPGVPFIKSRPEVPEGGFAPDGVRRAPSNYLGDDFVTPESEYGALTDEDSSSGGLIGTIINLIGLNGNKETEKNDAANLGKAVGNLIGSNNSPIPAKDMISNVLYKALTSGSVQGNDTDELTFNFSRPIELTSAQKAAIGENLEMIQSLITQPSSPLCNPKPIPVSDFNIDAFMGQWYQVMYSPPLASGPCSMVAYKKLADVNNGGAGTIFEIFEYTSDGTPYVKPRISSGYAILKQSGELIYRTTSNQDDVNVHVIYVGPLNSNGEYSFTILSTNCNYPIYVFARDPVVYRQRHETTVNQILEEMGLVNGFSRLFNIIAPVDNSICSFPPSLFNIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIW2</accession>
    <name>A0A0N4UIW2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Follistatin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1830</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPARC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIW2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIW2"/>
    <dbReference type="WBParaSite" id="DME_0000756301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000756301-mRNA-1"/>
        <property type="gene ID" value="DME_0000756301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972865at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16231">
        <property type="entry name" value="EFh_SPARC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000234">
        <property type="entry name" value="Protein BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015369">
        <property type="entry name" value="Follistatin/Osteonectin_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001999">
        <property type="entry name" value="Osteonectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09289">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00612">
        <property type="entry name" value="OSTEONECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00613">
        <property type="entry name" value="OSTEONECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Follistatin-like" evidence="9">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000756301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27370" checksum="906E9F260E1A84D3" modified="2015-12-09" version="1">WDELESLLENIDETDRTTPKVIEKNPCEDHICGWGKECVVSKSGEPTCECISTCPTLDGDPYDMVCSNTNETFPSLCDLYRERCLCKRKSVECKMNAKVHLEYLGVCKELEPCTDELMLQFPTRMADWLFQVMKELKKRRELNNLEWEELIAEAENDDEKRHVYPVIWKFCDLDIKPHDKHVSHHELIPITAPVIPMESCIKPFLESCDVNNDGNISIKEWGRCLGLKDGEIQERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ90</accession>
    <name>A0A0N4UJ90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PRA1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1929</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ90"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ90"/>
    <dbReference type="WBParaSite" id="DME_0000771101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000771101-mRNA-1"/>
        <property type="gene ID" value="DME_0000771101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000771101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15786" checksum="E32DAF28F2B1A1EB" modified="2015-12-09" version="1">MENKKWNEKIKWRKILYEKQPFPDNYSGGEEFLKELRKNENVVEYKLLEAVRGASRIVIHADAVVIYLLIFYLLSNFPSYSNEISMIILSLSFPLYGFHLYLRRYRNAAQNAADHLLTFAILLSFGYGFTPIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJE5</accession>
    <name>A0A0N4UJE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1974</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJE5"/>
    <dbReference type="WBParaSite" id="DME_0000777701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000777701-mRNA-1"/>
        <property type="gene ID" value="DME_0000777701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000777701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58940" checksum="E9A4D6FA98BAFD18" modified="2015-12-09" version="1">MFRRISRGFIRSVSCGLTLSAAGLSFYFLHQCDYDISSIGLVRLARAGIAVSKIIVDYKLTMRHYTEGDKYRKMISNTHRRSAERLLRLACANGGVYIKVGQHLAALEYLVPAEYVEVLSVLHSKAPESNMKDVKKVIEKDLNCKLEDVFVEFDEHPLGVASLAQVYRAKLRDGQQVAVKVQHPRVKAHSIVDIASMEVLTKAVAKIFPDFHLLWLMEETKRNLPTELDFTIEASNADRVRRMFSHLSFLKIPKIFYDYTTDRVLTMEYCEGAQVNDLNYFIKNNIDRHDVCKKLGTLYSEMIFVNGYIHCDPHPGNVLINKKEDGNVSIVLLDHGLYLTLRDDFRVKYAKFWLALLKPDQDEIKNIAQEMGVGDSYGLFACMVTSRSWEAVTGGISKSSVDEEERNEIKAYAASLIPQISLVLHKMPRPMLLILKTNDLLRSIEYRLGTQNRIDAFIQMSRCCIRSVNELALRNERHFIQRIFLCLNMYWTLFKIFIYEKYLEFFNKGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF1</accession>
    <name>A0A0N4UJF1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1983</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJF1"/>
    <dbReference type="WBParaSite" id="DME_0000778601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000778601-mRNA-1"/>
        <property type="gene ID" value="DME_0000778601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF252">
        <property type="entry name" value="RAS GUANYL-RELEASING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="147"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="483"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000778601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="595" mass="67234" checksum="1C0D68D4FFAD306C" modified="2016-06-08" version="2">MTSNCIINDNSPLEISQLIQICVNLFDDDVKSESFPSAFFHAHEWIIDSVELMARFISLYQELTSQPAQQLSLCRAVGYWLNTCPTHFEAAVCKLVEHLQKLALADGIPNAAKLLDISCLPSYPWLRNSSLRNPVGRQISLSFEQWSAEDISTSLSHIDYKALYRIPISELKRYCKDGNLSSTPILKQSISIFNSLSNWVQCMILSKSSPSERAEIMTKFINVGKYLKLLNNYNTLMAVIGGVTHSSIARLSKTMSCLTSDMKKDLSSLTQLLSSESNFANYWSVLKDTSDSFRVPIMGVHLKDLIAFHCKGGNMDRYRTYSCNQILKLAKLLSFFVSFNRMPHNFPNASIDLINTLKVSLDIRYDEDDIYHLSLKREPRTLLRPTKSVVFADWASGVCSAPDPENINKHISAMVEAVFKHYDHDKDGYISQTEFHQIAGNFPFIAPFGTIDVDRDGQISKSEMKDYFMQLNKHSMDFRREFKHNFQETSFLTPISCAHCGKLVWGFIRGFKCKDCEVVVHAYCKDSAVVECRRQSSSLTLLRVSAPSSVKQTKKLFLNSPDDDALPSLACEEVFDDISPCLSVGDFNSVDASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK97</accession>
    <name>A0A0N4UK97_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10267</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK97"/>
    <dbReference type="STRING" id="318479.A0A0N4UK97"/>
    <dbReference type="WBParaSite" id="DME_0000813101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000813101-mRNA-1"/>
        <property type="gene ID" value="DME_0000813101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970620at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019322">
        <property type="entry name" value="TIMM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10171">
        <property type="entry name" value="Tim29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000813101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21739" checksum="EBA5000C17F8FBB1" modified="2015-12-09" version="1">MFARFRTNIFEYGKTIANDYKTVFVDAFVEARRKPVKAMLISACLCGLGYAYKTNPSESDFLESFVERRVQLTLLPIAIHNRKTDEAMQRLTKYIQHNRLEYYNFIFFSIVLRREYGKQMGIYYSTDPNLKDWWWRRLPKNFVDFGAFGRWYNLEKYFVDYDINENEFEQNDKISSNRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKD0</accession>
    <name>A0A0N4UKD0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2243</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000051">
        <property type="protein sequence ID" value="VDN52270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKD0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKD0"/>
    <dbReference type="WBParaSite" id="DME_0000816701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000816701-mRNA-1"/>
        <property type="gene ID" value="DME_0000816701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="9">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="414"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000816701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="479" mass="55170" checksum="12B5B2A5DDA1FD0A" modified="2016-06-08" version="2">MNNEFLREIISIFDERAQLDFAYSKTLQKLSTKLHKISQNAQGTIDQGWTCVAEQFEAQATIHTNLGSAIHDDIVQPLRAIFNSQYQMIRATDQLVDRELKRMNDKQSETFKTKRQLYNWSHDLEKVEQLIDKDNSSNIKLSVKKRKLLEQVTKTEQTYVDETIECEKQRRVVHGVLRKGVERLETIEKQRLAHSQTALGRFQRKMAQLGPNLNILFERHMTSLNNSINADPVEHITNLTPTSSAHHISYLCDFPAENFGEIIGAQRRRWTLERISSLLQKECEKRQENIPDYSISNTENNFNNFALHEFIEFMSFKIDEALRNLNGNQNHREYNRLIRYQIKIRDKTGLPQTILNIPIEESLKPIKQPNAPSLPTTSSIDDNEYDQILANGNHKETFYQANSNDFIAANTTDCSKQICRVLYDFSAKSDDELDISAGDCVIIEDKLGDDWLIGHKILNLTSGSSISKTGRFPTSYVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM33</accession>
    <name>A0A0N4UM33_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2732</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM33"/>
    <dbReference type="STRING" id="318479.A0A0N4UM33"/>
    <dbReference type="WBParaSite" id="DME_0000888601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000888601-mRNA-1"/>
        <property type="gene ID" value="DME_0000888601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000888601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37338" checksum="F6DE81E2CE3234C3" modified="2015-12-09" version="1">MCLQVKNYSDDKNVQFLYKYFGIILLILQQASMPLLARLSRYRKPSEVFITTVNVLTMEVIKLVVCSVVVAVNENSLRRFLAQFHVAVIQEPTEMFKLCVPGLIYAFQNNLYYIALSHLDAAVFYLLYQTKILTTTIFLRIFLGRSFSLRQWLALVLLIIGVADLHLNHKSPKLSPGIEQNPTLGLIAVFMMCVTSAFAGVYLEKILKQSAISIWMQNVRLSLVSIPLCATSMLLKDYAVITKDGAFRGFDLLVWIMTISNSVGGILISIVVKYADNILKAYAQSIAIIGAAIGSWIFFDFTPNFEFILASSIVILSVYIYTAYPYKTAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMH2</accession>
    <name>A0A0N4UMH2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2838</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000083">
        <property type="protein sequence ID" value="VDN52865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMH2"/>
    <dbReference type="STRING" id="318479.A0A0N4UMH2"/>
    <dbReference type="WBParaSite" id="DME_0000904801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000904801-mRNA-1"/>
        <property type="gene ID" value="DME_0000904801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000904801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30008" checksum="7DC81AE05A9FA226" modified="2015-12-09" version="1">MTDACHMLSDSLSIFLSIIAIRISRLPANRRLSFGFHRAEVLGALLSILILCSLTFLLVYLAYRRLTADKLEINVDMMIVTAIAGVAFNLIIFGVIHLSNPSHHSHHSHSSMSNINVRAAFIHALGDFIQCIGVLIAAFIIKFTGWTTADPLCTFLFSIIVLMTTSKIICDIINVLMEGVPSHVDYDSLQDDLKNINNVYTIHDLHIWSLSLNRLALSVHIVIDDSTKAIETTRKADQIVRLKYGIHLATIQVELFDNIMSSCNFCKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMX9</accession>
    <name>A0A0N4UMX9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2970</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000093">
        <property type="protein sequence ID" value="VDN52997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UMX9"/>
    <dbReference type="WBParaSite" id="DME_0000923301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000923301-mRNA-1"/>
        <property type="gene ID" value="DME_0000923301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="52"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="324"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000923301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="610" mass="70918" checksum="7109088ABD11A7AD" modified="2015-12-09" version="1">MESHIKLKNCELQTFAGFRVASIRYQYIGDAIQWEINPSADECLRNRLYTEGCLPLAAQVILIRNYLYLIFKNLTNGLIALSVARLIEDYIQIEFMPVVTKLSRESNELSLTLVEISTHMRPYTFTLQALYETLNDILKLKLVGGEILTLLNEKIRSNFSKSTNLILRKIEKSTLTDYYGLIFSWIRFGTIFEDCTHDFMVWDLERTKLFTANQILSNQNKENSSDIDLGDLDERFCAIEDLCPIQFTSVAKDIIICGKYVNIIEQIQAANSSTLQEQKYWKGKELADWLKLDYTDIINIVKKARIDESQNLVNLLRKRFKLDDVFDALRCFILLERSDWLISFIDIAKLPLNRPTKEISLKKLQKFFDNAIECSSLRGNEQRSMFEPTLASIDIFTLLRSIAESDKCTTLVSSSTGSAFSGIADNEKFFNLFNLRINVQSPLSFVFPPSIILNYSLIFRVLFSLHYALYILLIKHNCEDLMSDERSLIDNMLHFLNVYISHCSLHIIPNFWNDFMKKFAKSTSLEEILLHQNTFFKETIALCFLPDLEFINILSMMINIIMEYCNDSLVFENATVKWQDLSDDLRRILGKPNENNAYLQLQKRVFSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN92</accession>
    <name>A0A0N4UN92_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10646</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001231">
        <property type="protein sequence ID" value="VDN60673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN92"/>
    <dbReference type="STRING" id="318479.A0A0N4UN92"/>
    <dbReference type="WBParaSite" id="DME_0000936301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000936301-mRNA-1"/>
        <property type="gene ID" value="DME_0000936301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11397">
        <property type="entry name" value="bHLHzip_MITF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000936301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33688" checksum="FD9D3D21B0042218" modified="2015-12-09" version="1">MAQLIPSFFFVKIVYSRCRSDGSPLLSIPIHSPSFRQVVSSSAPTSSLDMDTIVRCNQDSSNEPEFCRDRRKKDIHNMIERRRRYNINDRIKELGLMLPKHSAEEMKLNKGTILKASCDYIRQLQNDRDLMLKQQQEVSELKEALQFYGKRVKELEDCLLKNGIPIPPPSSTLPISFLSATNSLECRTIKQEPFDDLPPSPSNAPQGFGSGIYLSHLSETTAAMRIASPINFQNSHLAKDRYDNNYFRLNSFILNVPLCGQMSPEIKWDQSGFSPDDQRNQSSGFNSYQSSSMDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNF3</accession>
    <name>A0A0N4UNF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3137</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000107">
        <property type="protein sequence ID" value="VDN53164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNF3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNF3"/>
    <dbReference type="WBParaSite" id="DME_0000943301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000943301-mRNA-1"/>
        <property type="gene ID" value="DME_0000943301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="197"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000943301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="868" mass="97375" checksum="55D51C5AF8F20CB6" modified="2016-06-08" version="2">MVFVKTYNLRFSLRRFSQCAEKVEQCIAIRRESINVWERRAPLAPLHVKELTKQGVKVLIQPSNRRAFAIQEYVAAGAVVQEDITEAQLIIAVKQIPLDELIPKKTYAFFSHTIKGQEDNMPMLDAILRKIRLVDYERIIDSKGERLVMFGKWAGYAGFINILHGVGLRLLSLGHHTPFIHIGLAHNYSKSYMAIKAIREAGYEIALNKLPRSLGPLIFIFTGRGNVSQGAQELFHHLPYEYVECKNLPEIAAKGQMNKLYGCVVGPEDHLIAPYASVIINGIYWIPGSPRLITVSDAKKLLQLIAISDISADLNGSIEFMKTCTSIDKPFTLYDADSNECSDRLDAKSGCIICNIDNMPAQLPSEATEQFGELLYPYVIDLLNCSTDRPLDELECADEIKRAIITDNGALAPRYEYITRLRLRRTNFRRPVTTVFPEMVKRVLLLGAGMVSDPVANYYSMKQKDIRLTVATLLDKDAQRLCKYGANIESVIVDVLRERERFEFLIKDYDLCISLLPYTLHPVVAELCIKYGVNMITSSYISPEMMALDSHAKLSDVIIMNEAGLDPGIDHMLAMECIDEIHQRGGKIKSFVSFCGGLPAPEFSDNPLRYKFSWSPKGMFLALMNRARYLKDGQVVEIDGDCGVLDSLYPINFMPGFNFIGYPNRDSLQYADVYGIAEECKTLIRGTLRYKGFVEAVKALKAVGLLSTQTNKIFSEEFGLAWNMILQRLGKNNSHLVEILLKLGLLSDTFVQGHGTAIDTLVPYLAKEFSYKQNERDLVILNHDIHAQFPGGINVSKRHEINLVAYGEPNGLSAMARTVGYTCAIVSDIILNDGIKETGVIRPITKEIYKPVLNIIKKFGVEITGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW4</accession>
    <name>A0A0N4UNW4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001238">
        <property type="protein sequence ID" value="VDN60737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW4"/>
    <dbReference type="WBParaSite" id="DME_0000962501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000962501-mRNA-1"/>
        <property type="gene ID" value="DME_0000962501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041064" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000962501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14258" checksum="B20D22CEFACA8CE9" modified="2015-12-09" version="1">MLFHFLSIISLVRGAKGGEDVPIPHCNKQVTVGRDVRQRPTVDPQLCARMDTPACDAIFDIKGRPVDADGIAATIQSHSNPNVDYMIPVRCTEPALKTLAEKTCPSRCAFCCLTKQYNCINGKYMPKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNX0</accession>
    <name>A0A0N4UNX0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SPOC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3282</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000119">
        <property type="protein sequence ID" value="VDN53309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNX0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNX0"/>
    <dbReference type="WBParaSite" id="DME_0000963201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000963201-mRNA-1"/>
        <property type="gene ID" value="DME_0000963201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21543">
        <property type="entry name" value="SPOC_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000002">
        <property type="entry name" value="Spen family transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SPOC" evidence="8">
        <location>
            <begin position="1385"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="167"/>
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            <begin position="220"/>
            <end position="334"/>
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            <begin position="366"/>
            <end position="432"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="485"/>
            <end position="554"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="579"/>
            <end position="613"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="650"/>
            <end position="726"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="765"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="830"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1188"/>
            <end position="1228"/>
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        <location>
            <begin position="1289"/>
            <end position="1386"/>
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        <location>
            <begin position="11"/>
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            <begin position="61"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <end position="1386"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000963201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1568" mass="176434" checksum="3CEA0426476F69AB" modified="2015-12-09" version="1">MQKCGKRVRLDSSSSDEYTNSKGSESDSTLMISKNKKQPAKSGAGRPRTSKASKAVYANEKISDDSESEHSARDSSQSDKEYLQRKNRKKKSATGNKESSTKKNKKFKEHNLSLDDVFGAYSSDEKEFMVVHKSPTDLTIGDRYSRIEKDLYDKKELDTKDELDKISNKRKERNKHISKSKVKSQCAKEKRVEDSSGSTVEKESIIKDKKIENSRKRIKTLDTDDLFGTDPDIESSAKKVKKGKSLVEVSIFGDESNYERKSGKRKSNKSNDFESNERREKNLVKKLRKEKRKREKSANGSNVQMMKESITSETHTNEPKIFETGVRNLEKNNSASDKIENVGSEEGADNIHDYIDANASKTENFAKKKQKDYDKQKLVDKEDIMSSSSTSDEKIKTEIPQRPMKRHGSRKTIKKEMHDQVNEIIKPDDKIEFSEDNGEVDLFSSKASSPHPLTIPSCLLEDASKWGADSTVSTTDEEDHFNFVAKRNIKNENAEPFPADDSHQRKMMAKDGGANGSDEDGFPSFTSSQLRSEFMDNSSPSTSISNSSSPSYLEHKTDCSKMLSTYSKTQVEDEKTALNKIDAPEPIFDSSVFNEKHNGEQGMDENDSSDSFELIDEGRVVSLHGRDEIEGDIHDVQETEDAVQSISVFDDTASHQSADEEGICVRSNYMSDGTSRRSSLAEAIRTEDTINAVASEQEDSQDEEIQNSSTEEDKEESSKMSDAGGHLDEVIDDVVAGGYMEIDADQLMLINSKKAKEQADREAAAAAAVASQQQQPQSISSVNSHSVAPSLQTPPVGQPSSVSVRSVGYPMHMSQPMSCMTQSPYLSAHHTTTHQDLYSKESNNASSMESSQTQGPLQNIQVSIQNLPQNVPEEIQRGPQQQVQLVSAQQHEGFPRIHSAEQTSDPTLAPQYSQLVIRQTSQPQLQQQQHKTGLFYSSNYYASMNSAHQQGTAQDALQRIDTLNQSHPSYVPESSTSLSKAVQYKQSQMVPRDFYPQSNMKQQVPITHRAQLQQGSDQEQEQLHHQQQSDIMNHGIDSVRKSYQVNSTTSSISQIQQTNAVQHHITNQHPGFPHVQSSSANVSSTAVTTTDSLQHQNPFTLSLPTTSATPFFQNARMQQQYIQMCRNTLFSQGGVASEQPDNNTVQVIRNYAEMFHAATSAYGVNMSNAYNSSHVPFATTSSALAPETTVRHSGMPSVQHVRPLQQPQQMQQQQQQMQHQSSGQMQTDPRFQHSIKAQLPMSEQQEENIAAAVAQQQLNSLYRAGGFPLNYSAVVHNQQNPQQNVIPNSLQRQQQEQKQLHQQQFHQHQMQQQLQQQAQQHQFQQNQQIQHQQQVQQHPQQPHHSQSQHHLQHQQIQHPMQQEITQPHHNVPGPTNHQQQNSYPTQTPLSKYPFLWQGVIALKTSEATVQMYKVHLNFEFFLKVKGNVDMLRHSLIQLATLINGVQVIRINQRMRMETGQLESVQVKMTDEQSYIALLCLPCGMNLEHIKSQTEIMKERFVDYLESKQAAGICSVGNEKHPSPNMIVHIFPPCDFATSFLERSSFGLFDVVRQQGTKNYLFVVITSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP17</accession>
    <name>A0A0N4UP17_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3313</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01000122">
        <property type="protein sequence ID" value="VDN53340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP17"/>
    <dbReference type="STRING" id="318479.A0A0N4UP17"/>
    <dbReference type="WBParaSite" id="DME_0000968401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000968401-mRNA-1"/>
        <property type="gene ID" value="DME_0000968401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="103"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000968401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29646" checksum="D2FA914DE72242AD" modified="2015-12-09" version="1">MIFRFDPCGIFCAFLTYIAMIYADYVVVNWLIVPTFSQSLWGVLHAVIFNTVLFFALLAHIRAMITDPGVVPIDKTFISSGDDWDSDQETIFMKNTLKYGENWTICTRCESYRPPRAHHCRICRRCVRKMDHHCPWVNNCVGEFNQKYFIQFLLYIGLSSLYALFLVMGAWIYHDEQSITGAKSPQGPIADHAKILHIIFLSVESALFGLFVLAVSCDQIQALFNDETAVEAIKRKTSGQYKIRFRSKKAVLREVCGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPZ1</accession>
    <name>A0A0N4UPZ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Citrate (pro-3S)-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10832</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001253">
        <property type="protein sequence ID" value="VDN60859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPZ1"/>
    <dbReference type="WBParaSite" id="DME_0001005301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001005301-mRNA-1"/>
        <property type="gene ID" value="DME_0001005301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001005301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10250" checksum="2B301CD45EC9061E" modified="2015-12-09" version="1">MVTHQRESSLYGGEELAISAWNVRMLMDIASQAITLSKYRVDIVYLSETRLLHFGSQVIIILARSRDTGYGYGASNNGVATVMSDKAHSALIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ88</accession>
    <name>A0A0N4UQ88_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING/FYVE/PHD zinc finger superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3679</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000167">
        <property type="protein sequence ID" value="VDN53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ88"/>
    <dbReference type="WBParaSite" id="DME_0001016301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001016301-mRNA-1"/>
        <property type="gene ID" value="DME_0001016301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001016301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20835" checksum="AACCDA00824CF12F" modified="2015-12-09" version="1">MTGPELKFVWLIKSPPKPLTFDSNSTSDGCSSISSSVSKDTSSANYEEIDDVLKSQLVIGSTQEQEICVFCLRLHRNDELLCESCEVSSIDGVHFSRHGRLVYLDEYMVNSNSTIGATLSTVVDDDQSGLNTSCTSNSQQMENDEPSYGGVIAEEDNCLLKVEQNSGKITLKEKHNEDSKMAETTESAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQA4</accession>
    <name>A0A0N4UQA4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3691</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000169">
        <property type="protein sequence ID" value="VDN53718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQA4"/>
    <dbReference type="STRING" id="318479.A0A0N4UQA4"/>
    <dbReference type="WBParaSite" id="DME_0001018101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018101-mRNA-1"/>
        <property type="gene ID" value="DME_0001018101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUSP" evidence="4">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="264"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="820" mass="94719" checksum="52A5652C57CAACDF" modified="2015-12-09" version="1">MFNIDINLLPSFKRRKENICSANGEKNLQMKCPGKLKMSEIRCLIEQVEKRFIHSSNREILYIVSSDWWCYFVATVAACAISNIRQISNESITLREDDHYILKPNIYEVLDYLLVREKDFEILNEWVGVALTERDIIKCLSFQTRDGVKKLFLSLYFKVKNNETKEMKRLLVDENDNIKTVKDKAIALMNIDSSTAVLFSAKIGKRVRSLKKNAPKWYKILFPGDILIISSINANLVESNNENEQKKDGNTENIVGKMTEIELCGLLNDTLTCYFNSAVQCLNSITELKDYFLNEHYRNDLNVKNETGGEILTAFAVLLKKLCSNGSVVDPQPFFSIITKYAPVFSSGQHDSHEFMAYLLNIFHESINQAEMTNQEVSQETWNNFLLKNKSIITQYMYGLLQSSIICTKCFQVNIKFDPFCFLTIPVELYEVVSVIFIPSSPREDWRKVLLFTILDGDINRLLFDNELIQNCSLNLLAIQVKNISGSEGKIIVIRNRILGKAELRVLPIAYCVPSSQKIDFDFINLDIFSLNQRFFLLNASGVNFVLQKTGETKARSDKAKLRRNSMPVFSVNKNHRSVSADNILLKEMACDYWLQYHPSLMAAKSVDLPDDKELDWPDTNEAGLRMLSLTFIWEQDFFEAKRKEEGLVTTEIDLRNQSIDTPSIHKLIDWYIKEEMLQDQNRVFCSKCGKLECARKKMDLCRMPRYLFIHLNRFQNRRNLARKVNIEVDIPVQAMDLSGKILVGTQSECVYDLVSVIHHSGSLSYGHYWAWVHKNNSWFNCDDSNIKLLDKLKDPFRSSSAYILLYRRSTDQATENLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR27</accession>
    <name>A0A0N4UR27_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10912</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001273">
        <property type="protein sequence ID" value="VDN60939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR27"/>
    <dbReference type="WBParaSite" id="DME_0001049501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001049501-mRNA-1"/>
        <property type="gene ID" value="DME_0001049501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001049501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14543" checksum="3A2C5BED70B37EC6" modified="2015-12-09" version="1">MFDNVFVINICSVPVPNGPNFVRRPSVLVDNCQDRDPPACFEARKCGYSIRDKCQMEPYKILARQLCPRTCATCCLTKEYNCDNGTTLPSAAATCRDERQNCAAIRATNSCGGVFRTTMMQQCARTCGYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URE5</accession>
    <name>A0A0N4URE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10938</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001283">
        <property type="protein sequence ID" value="VDN60965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URE5"/>
    <dbReference type="WBParaSite" id="DME_0001062301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062301-mRNA-1"/>
        <property type="gene ID" value="DME_0001062301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16521" checksum="7B7B6C4285D52C8E" modified="2015-12-09" version="1">MLISMTISVVMIMIESMQIKGDICIRKFILGLLVAHLFANVESEVSLCGANAQGRIHCYDAYNKNCMRCNCNRGYAVLRGRCVLEAIARQATSGRLQRSTESNLIALRSPNCGTNMLQLNRYCERGTCGSLCYCVDGYHRYGDECTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH1</accession>
    <name>A0A0N4URH1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4073</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000271">
        <property type="protein sequence ID" value="VDN54100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH1"/>
    <dbReference type="STRING" id="318479.A0A0N4URH1"/>
    <dbReference type="WBParaSite" id="DME_0001065201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001065201-mRNA-1"/>
        <property type="gene ID" value="DME_0001065201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229972" description="Alpha-galactosidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001065201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45355" checksum="98397AE5C5416A45" modified="2015-12-09" version="1">MINKFLFISFLFILYTKALDNGLARTPPMGWMSWTKFMCQTDCETHPYTCISEKLYMQMADILVQEGYVKSGYNTVHIDDCWMESQRDLNGRLVADRKRFPSGIAALANFMHSRGLKLGIYEDYGTRTCAGFPGSYLHEKVDAETFADWKVDYLKLDGCYIDTFLMPEGYARMGMFLNSTGRPIVYSCSWPAYLINHPEKIDYNLVGRTCNLWRNFDDISLSWNSIKSIIDYYDHNQDKFIPAQKPGQWHDPDMIIVGNREITPDQAKVQMSIWSIWSAPLIMSNDLRTIAPVFKRILLNPAVIAIDQDPLGIMGRLVANTTNIGVYVKPVTPCKGNHCSYAVADVKVMLLKLGLTNPNGYSVEDLWSGQYKGIIYPNNTYHVVVNPTGVDFWKATVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URZ2</accession>
    <name>A0A0N4URZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4223</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000430">
        <property type="protein sequence ID" value="VDN54250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URZ2"/>
    <dbReference type="WBParaSite" id="DME_0001082401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001082401-mRNA-1"/>
        <property type="gene ID" value="DME_0001082401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001082401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10394" checksum="4BC906EB4079C7E7" modified="2015-12-09" version="1">MIEINKFYAELQLLTTSLPKHYDMIIIGGDWNTGVGHNATAVSEATVQLSEKATKARMILTAGCFEDLQRKQHNGTKSLLEQRSLESGDGDSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USA2</accession>
    <name>A0A0N4USA2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4326</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000758">
        <property type="protein sequence ID" value="VDN54353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USA2"/>
    <dbReference type="WBParaSite" id="DME_0001093401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001093401-mRNA-1"/>
        <property type="gene ID" value="DME_0001093401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231915" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001093401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16141" checksum="29437957D499E594" modified="2015-12-09" version="1">MFAVFAILILFSLLQEVQSGVGVALTQCIPNAGPARPVPPPSACRDKDPTVCTAVFAPNGADAADNADPTKDFLVNAYCLNATLKANAEEICPSSCAVCCLAPEFKCGNATTGAAGSSSCTDIRANCAQMSSYCNVPPYSTVMSQQCRRTCRLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2V2</accession>
    <name>A0A158Q2V2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS5260</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2V2"/>
    <dbReference type="STRING" id="318479.A0A158Q2V2"/>
    <dbReference type="WBParaSite" id="DME_0000090001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000090001-mRNA-1"/>
        <property type="gene ID" value="DME_0000090001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044440" description="Store-operated calcium entry-associated regulatory factor" evidence="15">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN55287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000090001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24285" checksum="AB4CE5B20AB927EA" modified="2016-06-08" version="1">MCKISNFQFIRLVIICFLPISGSSDDKVRLTDVTALTLRRGQYTTARRSPAVPQLRCVGGSAKGLYEPAVIQCYNRGFDGADMQWECKAEMDEAYQFGMIQISCEGYSYPEDPYILRGSCGLQYELEKTKYYDNRSLKQKNENDENFSLETLVHFHRHRNCRSGYSTLFTLVLIACLFYFVYSVWPFSRDGNNRDHFGVCFIKYKRTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q312</accession>
    <name>A0A158Q312_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cystathionine beta-synthase</fullName>
            <ecNumber evidence="5">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5775</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q312"/>
    <dbReference type="STRING" id="318479.A0A158Q312"/>
    <dbReference type="WBParaSite" id="DME_0000141501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000141501-mRNA-1"/>
        <property type="gene ID" value="DME_0000141501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="419"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000141501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="716" mass="78242" checksum="30456783750A61C4" modified="2016-06-08" version="1">MASDFLDNRASRASSYSNGSILCNNKKTIKGTRNEFQTLRIFDGKPMKDILSAIGGTPLVKLNRIPQSFGIKCNIYAKLEYMSSGGSTKDRIAKRMVEIAEECGALKPGMTIIEPICANTGIGLALVAAVKGYNCIAIVPEKTSHDKITTLKALGATVVHVPNDSACDFMNFALKIQKEIKDSVILDQFSNIANPLAHYESTGAEILYALDNKVDAIVSVVNTGGSFSGIGRRIKEKCPNVKVGKLNYTGNDFIPISFGQEIIDEFIEVTDGESFRMARRLIREEGLLCGGSSGAAIIAAIKACEDMSEGQNCIVILHDTVRNYMTKFVSDDWMISKGFIKKIAKEAIRPKSEHHYGSSIDYPPKSRKVDYVWSTLNPEINTFPIPFKPWRGAPNRAAGETAQSLPNFHRPMLFKNALEAIGNTPLVKLNKISESMGIKCQVYVKCEYLNPAGSVKDRIALRMIEVAEQQGKLKPGMTIIEPTSGNTGLGLAMVSAIRGYRCIIVMPEKMSREKADIIQAFGAEVVRTPTEVSTDSPDSHFGVAMRLRDEIKGAIILDQFQNICNPLAHYENTAEEILYALDDHVDMYVAGTGTGGTLTGAAYKIKEICPNCIIVAADPEGSILANPLTSRPSLYEVEGIGDDFLPLTLDRNIVDIWAKTNDKDSFKMARRLIREEGILCGGSSGSNLCAALQNAKCLSEDQKCVVILPDGIRNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q442</accession>
    <name>A0A158Q442_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS7976</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN58003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q442"/>
    <dbReference type="STRING" id="318479.A0A158Q442"/>
    <dbReference type="WBParaSite" id="DME_0000397101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000397101-mRNA-1"/>
        <property type="gene ID" value="DME_0000397101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="15">
        <location>
            <begin position="256"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN58003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000397101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116922" checksum="20D17EAAB6FA32EC" modified="2016-06-08" version="1">MDDANRSAQKAVVFDRNGRREAAIYFYFDAANTLLELIAANKISSSYKATAEGYICRAETLKKQNISRKPSIKTEHQLNLERVEFLLNQALDYDEEGCINEAISLYSEAVELCLKANPSCDTEIRRKLRELSRRALDRAESLTKLKDEASGMIELNIPEPLIDEISNLTLSNDVTSPQRAITKQSNSNSNSNSNSKGRLEKDELMVLSATSNINGRLYVPFLNVDLKERFAFPIPYTDKDGILALSNKQKQWLKTWMRPDEFMESPKVIDVVDCGTIKQSIVSDCSFVASLAISARYERRFGRQLVTSIIYPQNKHGQPVYNPCGKYMIKLHINGVWRKVLIDDRFPVDENGQLLCSYSQKKNEIWVPLLEKAYMKVMGGYDFPGSNSSIDMHALTGWIPERIALKSECKEFDATTVFEKLCSRFHQGHCLITLATGKMSQFDIDRTGLVDAHAYAVLDLRKIQGHYSDKDNVNWTPELCKALDYNPLDAQQFDDGVFWIDYESVCHFFDVFYVNWNPAIFPHTFALHAMWSAGVGPVKDLYSVADNPQFLLEVNNELAPCAVWILLTRHITERDDFANNREYITVMVFKSGKKIYSPITQKPMMDAIRINSPHYLCQLVVNDPGIQKYTLVVAQYEKMNTIYYTLRVYSTAKFKLEKIKVPYTVKKKETGEWKDKTAGGCGNGASRETYRNNPIYQLSMDSISDDNDLLIELKGPREYSVGFEVRQISSCRNKKFDTKDSGAFRPGYAFLTLESVPDGTYNIQPMTFLQGQEGPFFLIARRYDTRTTIFSPEGRLYQVEYAMEAISHAGTCLGILASDGILIAAEKRNIHKLLDDEVLAEKIYRLSDNVACTVAGITADANILISRLRFWAAQYEYTYGEPIPVEQLVQTLCNEKQRYTQVGGKRPFGVSLLYMGWDQHFGYQLYQSDPSGNYTGWKATCIGNNHQAAVSLLKQDYKSPDLIEAKKLSMKVLSKTLDVKLSAEKIEMAILTRRGNKTVIEELGNLEVSRLIKEHEERERDQEAQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q459</accession>
    <name>A0A158Q459_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS441</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q459"/>
    <dbReference type="STRING" id="318479.A0A158Q459"/>
    <dbReference type="WBParaSite" id="DME_0000407701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000407701-mRNA-1"/>
        <property type="gene ID" value="DME_0000407701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000407701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19012" checksum="BF5CBD7F0D63ED19" modified="2016-06-08" version="1">MQMTQYLPDNLLALFEARPPLPYKPPPDELLIDRKRPKMTGVGQYVHLFEDFKDTPPKPIFETKEERRARRRKEKEELLAYKIEQGIATWNPTENTHATSDPYKTLFIARINYETSESKLRREFEQFGKIQKLILVHNKNGKPRGYAFIEYQHKESMSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Q4</accession>
    <name>A0A158Q4Q4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9165</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Q4"/>
    <dbReference type="STRING" id="318479.A0A158Q4Q4"/>
    <dbReference type="WBParaSite" id="DME_0000536601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000536601-mRNA-1"/>
        <property type="gene ID" value="DME_0000536601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="134"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000536601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40175" checksum="190951D422A6AA97" modified="2016-06-08" version="1">MQIIDRIKEFDVYSKPLDDFRVRTFTGGAVTIVCGFVIILLFITETISFLSTEIDEQLYVDSTSAEQRIDINFDVEFAKLPCSLITVDVMDASGDNQQDIQHDLYKQRIDLNGNNISDDAIKQGVVFILSTFLCCNTCDDVKNAYNLRGWQIVDIESVEQCKSDSWVRKLEDYKNEGCRVYGTVQVAKVAGNFHVAPGNPLRTHRSHSPVKFDASHIIRHLSFGIDYPGKNYPLDGKSFVSSKGGIMFQYYLKIVPTIYKSLTSPNELFSHQFSVFMNQKDLSLGLSGLPGFFVQYEFSPLMVKYEEKRRSLSTFLVSLCAIIGGIFTVASLIDSFIYRSSRVLQRKIELSKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5D9</accession>
    <name>A0A158Q5D9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9849</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5D9"/>
    <dbReference type="STRING" id="318479.A0A158Q5D9"/>
    <dbReference type="WBParaSite" id="DME_0000711901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000711901-mRNA-1"/>
        <property type="gene ID" value="DME_0000711901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="10">
        <location>
            <begin position="397"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000711901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68597" checksum="30AA6774FCA09A26" modified="2016-06-08" version="1">MKSLKEPKDPCTSISENLNYELKEWSTRPIYDGFKCYYTIMVYLGKGGFAKCFSAMEFNRDHQRQVALKVVDKKRLSKQTQQEKILKEISIHKKLEHSNIVALLNFFEDKLNIYLVLEFCANSTLLHQIHTSEDRHLRNDVARSYFSQVIDAVLYLHEICCILHRDLKPGNILINDHHQVVKLADFGLAIQIEDLPFASICVCGTPNYISPQVLEHQGHSKESEAWSLGCILYCMLIGKPPFETDSVEDTYSRILRCDYDFPIGCISESAQDLITKLLHPDMALRLKIPMIKMHRYFDTEHRNSNYLLSLITSQKDSQDTSSILDNYKCFGSLCRTTEEVNPISNGGVHSGDSGIVSDGYFPLKTQSINPLNLYELVMAGHYQVSNDPPQTISGILMVSKWVDYRNRYGFGCVLSDGSRCVLFNNNSSMVFRRETANTGRYSFFANTEQDPLCPIEWTTNDVIVNSNLIEKMKITSLISTFMDAELQMIVSYPFVPSQANPLILQKRRNGILLMIHAHGFAQINFLHTHYKLVLHQDDCGQIKLTIMHPNRRLFTFSMVPNCQMPVYQCPESRQAQLLVDKARLSLMSSSIRYHLSTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Y4</accession>
    <name>A0A158Q5Y4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10413</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Y4"/>
    <dbReference type="STRING" id="318479.A0A158Q5Y4"/>
    <dbReference type="WBParaSite" id="DME_0000856601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000856601-mRNA-1"/>
        <property type="gene ID" value="DME_0000856601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848155at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF11">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000856601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20244" checksum="428DA8DA4ECA6729" modified="2016-06-08" version="1">METTDKNLCRAQSLRYSLKGNYKNKKTIRSKSKVIAENESRLTFGQQNALLTTWKVIKIQTSIMRKILNDLENEYSNVKQIFQKAAVIDAFNREVESNKLGTLDDHVKLMISFFDEILQNMSDEIDMANRMKKIGQYHAKLKYSCAFNSEIWEKFGEITMETICSLDVVQVGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q624</accession>
    <name>A0A158Q624_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Calx-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS2759</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q624"/>
    <dbReference type="STRING" id="318479.A0A158Q624"/>
    <dbReference type="WBParaSite" id="DME_0000891301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000891301-mRNA-1"/>
        <property type="gene ID" value="DME_0000891301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162272" evidence="21">
        <location>
            <begin position="19"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="345"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="475"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDN52786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000891301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="883" mass="99440" checksum="28C0B3306F70D143" modified="2016-06-08" version="1">MLPYLLIISLLQTEYCASGRNCSTNDEIKNCVDGIIIPIWKPFSGLTLIERISRGLIFFMIIAYFFLGVSVVADRFMSSIEVITSMERTITIKRYGIEPFKIKVRIWNDTVSNLTLMALGSSAPEILLSIIEIIGKRFQAGDLGPNTIVGSAAFNLFMIIAICVIAVPNNEVRRQKHLDVFCVTATWSIFAYIWMYIILAIISPGIIEIWEGFLTFLFFPITVITAWIADVKIIQKRFLPHRYRSTGRGLIATEGEEVDEADPVLKAFEDNRAKFIQIMKDLRKKHPEMDPTELEKLAEYEIINQGPKSRAFYRVQATRRLVGGGDIIKKRVNKDHHKSLETLLQREEESKKNTCRIFFEPAHYTVMENIGQFDVVVRREDGPDDITLMVDYHTEDGSAEAGSDYIRAQGTLTFHPGERHKEITIEILDDDVFEEDEHFYLHLTNLRMRTADNRVTGLPSFNGAPVACIEMPYAATIMILDDDHAGVFAFKQGNFQVNENCGFVSLKVWRTSGCRGKVILPYRTYDGSAVAGNDYSTKENEIVFDNNQTEGEIQIGILDTGQYERTDYFFVELYQPIWTKKMSERYCSTFCRSRHSDDLLYLDSKHDKINLTSEQLEIAELGKPRLGDIKTCKIIIKESKEFQSVIDRMLRTANSSLMLGTSSWREQFVDALTVSASGISDRNTGESTVGGNIGNEKEGNEPKFMDYLMHFVCVPWKLVFATIPPTEYWGGWACFIVSIALIGLFTAVIGDLASHFGCWIGLKDAVTAISFVALGTSIPDTFASKVAAIQDKYADSSIGNVTGSNAVNVFLGIGMAWTLAAIYHWFNGSEFYVDPGTLAFSVTIFCIEALVCITVIILRRHPIIGGELGGPFRFKVTLISKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6H9</accession>
    <name>A0A158Q6H9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10839</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001256">
        <property type="protein sequence ID" value="VDN60866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6H9"/>
    <dbReference type="STRING" id="318479.A0A158Q6H9"/>
    <dbReference type="WBParaSite" id="DME_0001014401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001014401-mRNA-1"/>
        <property type="gene ID" value="DME_0001014401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF46">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="417"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="470"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001014401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="592" mass="65501" checksum="5C0D1A0335769BF8" modified="2016-06-08" version="1">MIIYYVISTVSFLIATIILGAVLIKILFMQAKDKNNNDKKLSCNVSTNFMDDSIKWPKPSASFLGKFKKAAVSSENGQCSEIARNILLAGGNAVDAAIGSMLCLGVVNPQFSGLGGGFFMTIYNSTNQHCLSLNARGKAPDSLNISTFYDNDYSKHGYNAVAIPAEVHGFWTAYKKFGSGKIVWEELFQPSIDLAINGFPVSFSLAAILTEREDQIRLDSALKKIFIDPITERAYEEGDIIKREHLGFTLRLIANSSDPIALFYQGGLAQTIAAEIFENESPVENREFLDEFVMCGPPPPSSAVVAQSIVAVVSEFFGREKGYSLESPLFYHTFIEAGKYTYGDKFKLGDAYFNEALMKIARNMTKKTYARWIKTMIQKKIAPKEYYNLKTNQRDDHGTSSVVIIDQSNNAVSCSGSLNRMYRFGSMRASPTLGIIWNDNMQDFSQPSKNGSNGNQHEANSIAPGKRPMSSMSPLIIYSKKTGKTKLAIAASGGSPLISAMAQVIIRIFLFNQTVKEAIDAPRIHQFGPSTTEYEKSFPQKLISYLINDYAQIMVPSKQYLGSVQALEVKENGFIYGSNDFRKPVTTYATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6J2</accession>
    <name>A0A158Q6J2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3739</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000177">
        <property type="protein sequence ID" value="VDN53766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6J2"/>
    <dbReference type="STRING" id="318479.A0A158Q6J2"/>
    <dbReference type="WBParaSite" id="DME_0001023801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001023801-mRNA-1"/>
        <property type="gene ID" value="DME_0001023801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826794at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001023801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31040" checksum="42C0F129FE3726E5" modified="2016-06-08" version="1">MYRWSNDICLDGGIMIGNKYVTTIGPPKGFIGKAIAQLIIDLKWSSFLILYSNPKDLMEMKELLNERSLSYSLQKSGAIIRQMPENTDAYHTFLEDIRELGETNIVFYSKDIDSITTFFKHAKRAKLTESRFEYVLMDLDVHLLGDFFTSEEGFECNVTSLRIIKTESPIETGLGLTMDAVSVIGTTILSLKASGNEILTFPLLCDGGSVWNDGEKLNSAINNVFLESERSGILQFDKNYERSKLMASGFRIMNDEFTMVSYCEVYFEINFSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PLV8</accession>
    <name>A0A3P7PLV8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PLV8"/>
    <dbReference type="STRING" id="318479.A0A3P7PLV8"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="553"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="89306" checksum="48A530EFB57A84F0" modified="2019-02-13" version="1">MLISEENMERRKRRSPVEEYIDSLMDSPEKLQRCTNFYQNLRSFYRRKWNCPFKAPYIQGVEVNLFRLYDTVTSFGGWQKVSMNEKWRDIAQALGVAEGVAVAEHAVKVLYMRYLSKYEQIELIGEVDDTDSDIITSRGRSKGCSSFATADCPISLLHRQISDYPRPWFERKVDSDYDGLVKGLLCGLPNEVDFAVNICTLLSHPGPRVLRLSAAPQLMTLLVAHVGIFPDDDGAIYHLYEGWRGASHRDFIAFWRGAGITDVEVLSLIPHVTVSKFPEDELDMFTGLEMEFEPRNVVSWRIQQILSIMRNLSFEIINKSVMASNWPLLKFLFICSNCKWSALRAAALDTLSNIACEIDLTSEEFSMTNHLLLKTVSQCLHSSDKFMVIRALEVLAGLCNNECNESLLCEFLNTRILGKIFDAICVKDVMICVYTLEALYQISELGATACHQLSHYPHAINMLINLATVEAVSFAPTGLTGMKVVEFHGPSHTATSQNHSTSHVTRPASFVPPSNTVTNQTPPRSVVATHSSQSRALLPTIPTIGDTKVEQLTAKWIRLNCLLEAGNIIPRGELYACYVEDLRNNYNALSGSVQMFTNIIKAIFPSVVVRVAPNTNSMVFENLKLMKSNVQKNAATSGRTNIAHKTSSAIAASHPVMKKMLSENNMSGSAVNGRLTTSPAEQKQDIGISHSNSPTASVSEDIPRPNPLVNSSSQNSTVEVNSAGTSMTVPSSFPVPNKVQLEVCRAAVEARDVISDDDHHEAKIVRIENTGLKSSATTSEPATSNVNSNPKSSVEMVNFITYKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PW64</accession>
    <name>A0A3P7PW64_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PW64"/>
    <dbReference type="STRING" id="318479.A0A3P7PW64"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="150" mass="16248" checksum="16B6A05A8B23568D" modified="2019-02-13" version="1">MVATCDIVIAGQNALFSTPGAEVGLFCSTPGIALARAVPTKVAMDMLLTAEPIDAQRAMQIGLISRIVVDDHVSSEALKVATKIAALSRTVITLGKKFFYTQTQLPVIDAYKMGERIMIENLCLKDAQEGIAAFIDKRAPRWTHTNDKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXA0</accession>
    <name>A0A3P7PXA0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UNC80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXA0"/>
    <dbReference type="STRING" id="318479.A0A3P7PXA0"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 central region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="3">
        <location>
            <begin position="246"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1477" mass="167878" checksum="80D34887CC5444CE" modified="2019-02-13" version="1">MQSRPRIDPVLLYIRTQMLCIAHAPLSTLLKSCLTFSQTQFKETLTISWYLLTHKDPHIAIAAASMFIVTSIRRPEDILAIMHRDMSHEDPNVRTASIRRFHILWRSRFYVWLKLEDGAQTNLKVPPPSIDFTLPSPSIGQSQVAIVDPPWMPHIKTKVEELTLKEEEQATSQTIMTMTRTRRKQKQEMVKRAVHEADERQSTLRQKFVFRAIPILQQAAYEPSLFHHQINLQQIQSDGSAEEGEMHPLSRQQLPVAQPLFPSAILTVVPKIIEMLDDVAIIWSCIVEDPALFLRHFLEKLTNRDRQEYLISLLKKLVIMFSPLPNQSAYSLLNYLFGFVMYYVRSPCDGSDKAIGMALSLIWLIAPDVHGLYFKDMKQTLKKEQCDQALMITANVPSAKKIIVHGPDCGNGGIPSQFPIHEDTQFQQILTDSLEFFNIPENEIDCYFLVDTKTNLVHMPFSYVRDFYFFHRSFYPQLTLIKMEKNEAEFRMRTTALTQKFIEIGKVLLTHNALSHSPENVIPQRIFFLHDEFTHLPSFPRKSLETCFGMYNGLMGPELHAMDTIHKFVWAQLVSDMFERMENAFIFGDLHLFINVINGIMLMHCEEVTILRRCMATYLSMAIHFNTLFANQGFFLIMPTILRCYSQRQTNSLLCRTIEFVCKQFYILHRKPFFLQMAGSVANILDINDNDFEINLSKIKAKYWFSLIRSMEDMSDLHDFLDILGLVNEAKPLKAIDLCYRDDPNTFSILTDGLASCVTVCAFAPESRRSYQMLLIMQATIPYYIDHMEKETSAQSNSTSAVKHEIAFYATLCVEMKALVTCCEILARGPTRTFDIVNSVSEKGKSLIADSPQFFDPPTVLEDEGKAHYFNTTVGEKKEKKSVCGWESSDSEMQREMYRRSRDAILILSANFIDKATPRLKELAKLLSISEHCKIPEVFDHKCHVKLSEIALSLLKVAPYDSNTMACLGLQKYFMSILPITDWSVESNRSTLNIILRRLDKTIQKIAKKMASRRRTNWNALTNWLVGLDYTLSAFPYIAHLHPLKTTTQMCLRIMVGDPCVLDEPLQSTAHNFSSSTVLHALSPPQSFCNVVLKIASFLMQTLGQLSFSLEFFCSTEGIGPMADRLEAVLCHILIPLFLRATMSKRDSPQFHAKDIAFTLNLLQNAINPALAKQNIALPASTSLATSLIRSSTSAVHADTAARQGSVSVTDRGHSATVSTHCIVRESIYQSVFLALKVMMVSFEKQMSIHWVRLSKIIRELICKKVGGPSLSSFIEFVLSSNLPVSLLILPVMQNKINQKAINEQEILWQNEFKERVNRFTNVHSEIRSLGSILNELSQELQAMKEDFATRPFEVARSHTPTITADLHSETGSAHSGPRLSYSRPSESRRLSSTNAAKLTTRAGPSSGQGEITLKNTIVEDEEVAQLQTVTAPVRISKSPSLPANKIVSFITPKYVRHDSSDGEDFVDRITACHHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0N5</accession>
    <name>A0A3P7Q0N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001281">
        <property type="protein sequence ID" value="VDN60960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0N5"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="66" mass="7725" checksum="8CE03100C1F9E007" modified="2019-02-13" version="1">MVVVRHQNLRVLMQKSMSKSSKMFELDFCCRNSAEYSEMCRVEGVFVLDLCIVTKQSWAIFKKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q1J0</accession>
    <name>A0A3P7Q1J0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q1J0"/>
    <dbReference type="OrthoDB" id="5782406at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="158" mass="18151" checksum="F891EC5979C45F6B" modified="2019-02-13" version="1">MLRICYSCSYSRLEPTRANDDYFCANETLILMDKELTQRPCAAWEKYCVTTIETSLNAFSSIARSCNEACRVQCESDGYGTDMVRCDDCCETDNCNGNFSVHYYLEVMQAQYTSWVEPMQNERSFNKAQGFHFPYGCANSVRKAAFNIILSLFILILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QR14</accession>
    <name>A0A3P7QR14_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7110</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QR14"/>
    <dbReference type="STRING" id="318479.A0A3P7QR14"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="403" mass="47115" checksum="1154B6F6D0E9F0D0" modified="2019-02-13" version="1">MTKSIPQGSDTLGCCVDSVLLNLPQRWRNWIVRGIFSILMVSFFIYIIKLGPTWLMALVFVIQFWCFHEIISIGLVIYRLYDLPWFRALSWYFLLSSNYFFFGESLIERWAILLRKDEFLHFLIVYHRFISFLLYCLGFVWFVLSLRKGYYMRQFSLFAWTHVTLLLIVSQSFMIIQNIFQGIIWFLVPVSMIICCDIMSYIFGFFFGKTPLIKLSPKKTWEGFIGGGISTIVFGLLLSYCLLRDPFFVCPLEDIAEENHNNCTIPSIFQEFQLGRPFSWFFKVIKKSPSFHMYPFLGHTIIMALFASILGPFGGFFASGFKRAFKIKDFGDVIPGHGGLMDRFDCQLLMGTFVNVYIHTFIKVPSANKLLQQLMLLPDEDQIFIYESLKERLFQEGLLPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SJ14</accession>
    <name>A0A3P7SJ14_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SJ14"/>
    <dbReference type="STRING" id="318479.A0A3P7SJ14"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000019">
        <property type="entry name" value="DNA N6-methyl adenine demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="683"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="1034" mass="120987" checksum="D26C5831FC757F7B" modified="2019-02-13" version="1">MILIFDFLIFRVKNLSLENAESYRNYKKYIYSSRHEKAVFDKTLGKSSDIEEIARLTRNADELEFLNEENYVELEGLLLVKDFLNKEVEEFLIKKIDRKEWTLSQSGRRKQDYGPQVNFKHKKIKVDRFSGMPDYIDIILNRMKEVSPNRLGEYQPFELCNLEYVDERLSAIEMHFDDSWIWGNRLICLNLLNPCVLSYANDERQLLVYVYLPRRSLVCMAGKVRHEWRHAVFSEHIRGRRIALTMREPSPLFQVYDLNVSSDIVIYTNTMEHYNFQEHIVNVIRPRFVHLLDKMKSEKSANLLEAMFVLINSTYRAVNQEIKSDRSGQVDENSPFAVSWHFVPYSLFCSEVTLKMTFLLNECFKFTYSIFESILKDKRISESLRHKADLLDKALGINNLLTDSQAFNVSLKIVNISLKHASFSIISDFTERLCTDPSKSNLLKSLKKKINCMQKWAKIIGLDKYFNSLFPSLKVFLEKKIVDQLNERVCFFLFFLTIAITIRIQYCRLQAYELVIKSYPASGNIIDDMRFCMESNGGYGRENLVEKLSNDVKTYLLHIGVSTVDILQGYANAVECLRRLDPTCVIMQKICSIIRTYIKQRPDTVRCIITYITGEMREELSQQLTRKRTAFIDEENLQGINDELIANEEESEEEQWMNWLPDPPDAIINQSRRFRQNADVFNMLVSVYGSKELFVKEYRHTLAERLTKSWNRDVKPIFEMRYLDLLKLRFSEGELQHCDVMLKDMRDSERMDYIVFNKLVRFINFSNFFSFLIYSNTISVDNFNILLIFSFQIHQNSSNFPISARIISTFFWPKIDNEQFELPIEMISGLASYGRAYEAQKGSRKLDWMTGVGSVEMEIHLDGLITTINVSPAHTAVLAQFTKKEQWSLDELSVTLGMEKRSTKKRLEWWQNSGIIVYSAKQSNGEREKWCLATWNSKMDRLRGEIDVESDESEDEKLEDSVAVDALEQYWTYTRSFIASQEPIKAERLHSIFKMLASPGQQGPSLEIVISFLQRKVKLNLLSCVNGLYKVVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T1B9</accession>
    <name>A0A3P7T1B9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001198">
        <property type="protein sequence ID" value="VDN60012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T1B9"/>
    <dbReference type="STRING" id="318479.A0A3P7T1B9"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="723" mass="83327" checksum="76F7A694C46C0A7C" modified="2019-02-13" version="1">MKNYDQNSISINHRHPRKAPGPTSCFFLEKALKRIYPKEDFEILESLGEGFFSNVYKVKLNNTDEVMVLKIVKERENRLRAKANIMKEITVLNQLVTHPNLIEFRFFSYFYIFLYFSGVCIDSCSGTWNMHILVDFCDGGSLNRLITDRSRSFSWKMRFALAKDISAAMCFVHSKNVMHRDLTSMNVLLQTLPYGNLKAVVADFGLSCPIPSRNELLVQVGTPFWMAPECLKEEFYNEKADIFSYGIILCQMIARIEADPEAGLCRTNNFGLDYVRFTAYCENDTPLDFLQLAFHCCLMNPTGRPSFSRIYDRLNSFTYRQWKDHVTARNFDSQSLVTEQSKVFISLFLFVMSWDVQCPMQLSLPPAEVAIHSNIVRQKTSKNQNRLSIENFQSVCYSSKENFGFDKEQFGRKLQMEELARSIAIEELSDEASSYFKSGFSCKESSIRGNPFLNHQIYSTTRKLGLFKISRKNVRKEKINDNKSHFMHINSITDRQNIASFNMTVNVENNDRKRKNKEFKQRRSRSFPCSAFSRKDFTSTFPRLSCYRRPSNHREVIPADIKHRVFLSMYIEQKNSNNCIGSSELNQLKKNEQAAADSVTINLPSYNNFLSDSTFLKQNNSNISYGSQPTYINRSTGQQMLPSGKSQDICLSLNPCSKFNQARLFIVYQVDLRETVVTSTPKSNLTSSSSIMCLMRRKISCKSRKNNHGTIMEVHHKGGCNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U177</accession>
    <name>A0A0N4U177_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4701</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U177"/>
    <dbReference type="STRING" id="318479.A0A0N4U177"/>
    <dbReference type="WBParaSite" id="DME_0000034101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000034101-mRNA-1"/>
        <property type="gene ID" value="DME_0000034101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799706at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000034101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22708" checksum="78F84CF168890C04" modified="2016-06-08" version="2">MSTLSELITTCDDIPSLQQNISSYPGSSRLAGVPQGLSTHLKNMEESPNPEGISQLKQLVLANEDEPSPIQAQTSSVHPNKQCLEELLASGPLPTTNLGRAVENLYEAWSRLLLEMSASTGFTNPTLEHIKETAECGIRQLKDSCDDLCGEFTKVSLSWRLNHLEEAAHEDIEDLERAILRQEALLTRATGTLQRCLANMNDNRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U178</accession>
    <name>A0A0N4U178_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRY_EERY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4702</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U178"/>
    <dbReference type="STRING" id="318479.A0A0N4U178"/>
    <dbReference type="WBParaSite" id="DME_0000034201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000034201-mRNA-1"/>
        <property type="gene ID" value="DME_0000034201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070965at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000034201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="10278" checksum="0CF95FF5C311311F" modified="2015-12-09" version="1">MWHEARKQEKLIRSQMIDSVKRNERRKQFYENVRRDPEQFMQIHGRKCQIHVDPAIWRAAEASNILLIFIFLFLISIYGFKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U181</accession>
    <name>A0A0N4U181_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4705</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U181"/>
    <dbReference type="WBParaSite" id="DME_0000034501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000034501-mRNA-1"/>
        <property type="gene ID" value="DME_0000034501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860166at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000034501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8543" checksum="95E0854DAAD0733F" modified="2015-12-09" version="1">MVGNATHWIGLRKVKGNFQWFNGKRYRFAYWKPGEPNEGDAASCVATNAITGQWLDSTCNKVTDKRGIVCEKHALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1A9</accession>
    <name>A0A0N4U1A9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4739</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1A9"/>
    <dbReference type="WBParaSite" id="DME_0000037901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000037901-mRNA-1"/>
        <property type="gene ID" value="DME_0000037901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835957at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000037901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="70169" checksum="AC796DE449029C4B" modified="2015-12-09" version="1">MGVGSYVIYRMFVRLLGRNFLWRIIDQVRLDLLNLSRQELYLLHSTQVNFGVDQSLLAVAGANRLYVDNCCEEFSRRILSSDESERRRKKRFISKYSCDRQFSSTSFSSSFAERWQRDKVIRLRYACAYGPSVISFCPVRKAHFRYVTTKNYIKVTAELSCDLAIYRNGQHPKYQNSLVSEQASHQRSSELTETRSEKSASLRLLWDDPEWDDQMDFPGQYGLIFASFSDMVQYGRNSSPSDMSEMSEFLAAKKVFDDASSVNNLSKDSNDLCGVSSDSLSVETNDSVIGARDFIQRNCMTDSKHLYQLVTDFMSSDAASLWSGCSTRSFRSLRYCAAVNSNGLLGVTQILSHTTHPKCDIFSNSMTDSGISRGTTATSVYCSRDRSLIFDSMTSSKFVPAEDEACCSGLAKAFIINSTSCDLKNESIIRRSVLIDEDQQSLTQTQRSLEWDEEFEECDDSRNVIVENLDNFKDSKNSNTEHNSCKVSSGKCLRKTRDLMVWAHQNYPLDQVRLKVFRELYSLRGFKRIGVERNGNINENFLASVLHIMLAHKVSFFSRHNLTNAQKQKRENATIAVVNKILMQENEKQVYSLYSLENRAAERNIVAVSQIRSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U254</accession>
    <name>A0A0N4U254_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication protein A 70 kDa DNA-binding subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS5089</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U254"/>
    <dbReference type="STRING" id="318479.A0A0N4U254"/>
    <dbReference type="WBParaSite" id="DME_0000072901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000072901-mRNA-1"/>
        <property type="gene ID" value="DME_0000072901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="264"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="408"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000072901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="595" mass="67433" checksum="721E5C60B42ADB6B" modified="2015-12-09" version="1">MSFGFVTASGKNIKVSADALEKARKRFEELDEQAAADEHVSLVAAALPQHKNLFSPILSRSGLKGIGSKESAFRSSLCSTALKRHKGMKSVFLQDCAFHSPVLLNATTTSSPAVFLDELDKNRILEFSPQSKSRERSNSENVTPIKLLTPYCKSWRLCLKVTYIDKLRQYRGSKLFSFQGVDEDGVEIRISAYNDLAVKISHMVRLHEMYYIQQASVKISNKRYIRNQHDMEIILKSDTQIKLCTDRPEISSPKLNFKFVHINDIKNYMDSDVDVIGVIIDTGDMKQVNTKSGENIFKRDIQIVDESVHSVVVTLWNERAQTFNKSFQNAIFAARGLAVRSFHGFLTLSALTYSKTVINPDIPETLSLKMWFDSILKKKSFVSISSDPLQYVDHVWINQVISASNPSYFTVTAMVLNMNVDNAIYKGCVNGGCKKKLLECTDGYKCPKCGLISDKYKYFFTLSKKFMLKFINWMIFQVEIGDFTGTLLVSLFEGCAEKLLGDSADELAKIRSYNADEFLNRLRRPLFKTFSFRITARQESSSTGQNNVTKSVSSTSLDKSLSPSNQRFKWNVVGLTSLAYEYYIPFLQKCISKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U265</accession>
    <name>A0A0N4U265_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5103</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U265"/>
    <dbReference type="STRING" id="318479.A0A0N4U265"/>
    <dbReference type="WBParaSite" id="DME_0000074301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000074301-mRNA-1"/>
        <property type="gene ID" value="DME_0000074301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF90">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000074301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26598" checksum="5EBC487B52C8497F" modified="2015-12-09" version="1">MPSWKKYARIVLPHIGLILLSILYIFGGALAFYQLERPNEIQVRKMNLQKIDHYRKYMLNELWIMVNDNSTSDEEVERLTMVHLDRVTRLLFDAFDTHFITSSHLNEFANDDECTWTLTTALFFTTTLLTTIGYGNLVPVTVNGRMFCIAYALFGVPLILITVADIGKFLSENIVWLYTRLVCIPFSTYLNIRNHISHQKKKREFFKITFFKKLVLNLLFKKLSQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2R9</accession>
    <name>A0A0N4U2R9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5354</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2R9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2R9"/>
    <dbReference type="WBParaSite" id="DME_0000099401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000099401-mRNA-1"/>
        <property type="gene ID" value="DME_0000099401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5911931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF4">
        <property type="entry name" value="PROTEIN CBG15747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720817" description="Abnormal cell migration protein 18-like fibronectin type I domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000099401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26675" checksum="6199BCD96FB2C970" modified="2015-12-09" version="1">MAQIWIILLLINIAFVLNDDQQSKNRCWSSGNGSSARWWENGTRIDRGRYWYECIHGHLRPMGCFTPLNERLELYEKFVQNGYEMQCVLENGYLQFRFTACISEDGKRHGIGEIWEDERNMYWFECKADGPYLKVEIRGCVSHDKTKRIPLNEAYEFGGYVYECQKKYNGTVQMCSVGCVHNGVRYKIGDQWPVNFFLQFHRASQQFKILIARMNYFDFSEKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U376</accession>
    <name>A0A0N4U376_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5530</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U376"/>
    <dbReference type="STRING" id="318479.A0A0N4U376"/>
    <dbReference type="WBParaSite" id="DME_0000117001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000117001-mRNA-1"/>
        <property type="gene ID" value="DME_0000117001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF377">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000117001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21227" checksum="6942AA3596778096" modified="2015-12-09" version="1">MKPRTGLACKCFICGRVFTSNMALRNHQSVHTAAKSFACSFCDRSFAHKQSLRIHERIHTGIGRRHFCSVCGKWFKTEDEMLEHQNIHERTHTGEKPYTCGYCGKSFTQSQALTIHIRMHTGERPYTCAICSKDFRDSSALRKHEFLKHTHGRASTYSHVDELLMMSMARNLIQEENSRSPTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3I6</accession>
    <name>A0A0N4U3I6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5651</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3I6"/>
    <dbReference type="STRING" id="318479.A0A0N4U3I6"/>
    <dbReference type="WBParaSite" id="DME_0000129101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000129101-mRNA-1"/>
        <property type="gene ID" value="DME_0000129101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF97">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000129101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31262" checksum="8D84C0FE6F1A1456" modified="2015-12-09" version="1">MSSTIRNCRQPEDLNEFLNPVGDIIEGYGNVTPKTNHGRIFVIIYGLIGIPLSMLAIANLGKFLSAFLKRWTKSAVKNFRNFFETGRKRFRSKEKQALVNYNDIHDVNVGSWLDAIVLLSAFFLYLIVGSVLIAAYEKEMDFFGAIYFNFVSLTTIGLGDLIPKNENYLAFTIIYCIVGLSLTTIAIEIASEYLKKLHFFGRKLENVGNVQVWFGGKMLTMKQLVRNLGDQFNLPENQIIDLNLDQFVDDALKVEAGELPTLRVINSKKSYSSLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3N6</accession>
    <name>A0A0N4U3N6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5706</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3N6"/>
    <dbReference type="WBParaSite" id="DME_0000134601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000134601-mRNA-1"/>
        <property type="gene ID" value="DME_0000134601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000134601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11896" checksum="3A92857E3E9C2ADA" modified="2015-12-09" version="1">MFCEESYTGIPLTNLGSWHVVWCSRTVLGWLRSILPWSPFLFGSGIFIRCPMRFKIVVVAASMNAVALLSSASKLLLVLIGIVNVINSDSYALKFATNLTVIVTFVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U457</accession>
    <name>A0A0N4U457_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine/threonine-protein kinase Sgk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5911</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U457"/>
    <dbReference type="STRING" id="318479.A0A0N4U457"/>
    <dbReference type="WBParaSite" id="DME_0000155101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000155101-mRNA-1"/>
        <property type="gene ID" value="DME_0000155101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="231"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000155101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35429" checksum="D5F8A57E47AF94F4" modified="2015-12-09" version="1">MKVMGKEQIKLRNEIKHVMAERSVLISNVHHPFLVALHYSFQTKDKLYFALDYLNGGELFFHLQKEKRFTEDRSRFYIAEIGCALGYLHENNIIYRDLKPENILLEKTGHVVLTDFGLCKENMKSSDMTDTFCGTPEYLAPEIILKRPYDYGVDWWCLGSVLFEMLTGLPPFYSKERMIMYDHILHQPLSMPKNISPSCKQILKMLLHKNCRKRLGAKSDFQEIKEHRFFEPIDFEMLLQKKLKPPFVPQIKDDMDTSQIDHEFIRQKPNPASLIPERTYNASDADFPGFSFPGRLLIEIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U464</accession>
    <name>A0A0N4U464_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5920</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U464"/>
    <dbReference type="STRING" id="318479.A0A0N4U464"/>
    <dbReference type="WBParaSite" id="DME_0000156001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000156001-mRNA-1"/>
        <property type="gene ID" value="DME_0000156001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057951">
        <property type="entry name" value="CPSF6/7_RSLD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25524">
        <property type="entry name" value="RSLD_CPSF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="119"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000156001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="59273" checksum="EBAAB7283F239461" modified="2015-12-09" version="1">MTDILDQPDNDLDVYGDTEIDPRYSERDVLGDDDETDVLKNDNNNGAQNGGNGDVVIVKSEANDSDLYDAAIEPSGQHGPTTTTVASPTKSPAVSRQASSSSQLPTLGLSNPNSGGRRYCCYIGNMTWWTTDVDLQSLILSVGATDLIDIKFYENRNNGQSRGFALAVFTAENAVKIVMEKLPHKTLHGQQVVVLPYTKASLAKFEDATRSRDQQRTEKKDAKKEEQKAPFVGTIRIGVPPQQPQPQIQPAPMSLPPPMSLRPQVQVPPPMTNMRPPAQVPLMIPQQQPPQMRGPPPTTQPLNLANLTVPARPPVNLSAPPPGIPQVQLGAGAPPMTRPPPGFGQPPQAMQSLSNAGPTHPPLAGAPPTSHPPPSFPPPGAHINPQVYRQNFALFTYEFEGGGPAPVPSTMDGLSDAEFEEIMNRNRTVSSSAITRAVSDAAANDYASAIETLVTAISLIRQSRVANDDRCKVLISSLQDTLNGIENKSYNSSSRKHRSARDRSRSPSERSRKRHRRSSRSRSRSRERYDYSPRHSSSSNRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4I9</accession>
    <name>A0A0N4U4I9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase subunit s, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6063</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4I9"/>
    <dbReference type="STRING" id="318479.A0A0N4U4I9"/>
    <dbReference type="WBParaSite" id="DME_0000170301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000170301-mRNA-1"/>
        <property type="gene ID" value="DME_0000170301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859291at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000170301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23754" checksum="FCA6B0A221526028" modified="2015-12-09" version="1">MASKIAFLNRFRKILATHELFGLRWLLDGFNHYDDDRVREVGPDRAAAEWVVRCEGKVRFDVWDEFIENYNDLLRRTSCLDPKLPQHQVHIISISAIHSSISGRGCVHLYGLKKIKEICFIHCKAFDDTGVEKVSRLTCGTLEKLRIESCPKVTEYGLRFLGNCSNLQFLLLRDLPRVYKKTEVLQYLKSSLPKCDICYPDSNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4N3</accession>
    <name>A0A0N4U4N3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B8 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6112</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4N3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4N3"/>
    <dbReference type="WBParaSite" id="DME_0000175201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000175201-mRNA-1"/>
        <property type="gene ID" value="DME_0000175201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000175201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10956" checksum="A383D1F8D99D6A39" modified="2015-12-09" version="1">MSVIKLGSGSLRELRIHLCQKSATSSGVRSFIENDYFALKKANSDFPILIRECSGITPRIWARYEYGVEKYVSLENATRENVGNIIKQLASDQPTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4P0</accession>
    <name>A0A0N4U4P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4P0"/>
    <dbReference type="WBParaSite" id="DME_0000176001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000176001-mRNA-1"/>
        <property type="gene ID" value="DME_0000176001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000176001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47623" checksum="D858574DDBDF7169" modified="2015-12-09" version="1">MGEWDLFRKVARCAIVDNISIPPEQKGSSRFGFLKCVSTDAANSILQAFNKGCFKEDGSNGLQFSDYKKKDRPITNNRARKDDANKLVGKDKDGKEDSSGHSRLNNFANDTLLHRKQIPLVYSNLFFKHNDLGIGKVKIAVPRYHWPFVFYALPLSEEIIQTKTMLQEQGELNRQMKEHALLSRQLKEIKGLASSELCLNSCGRRSMTEPAQMMLNDDILNADALMIDQDIVNLIGLPGELYKNIDGKNFHDSHQNCLLVDDLVIFEATIDNLHDYWRGRVLEVNDKTADVLALDKAIIVSVQFSYIFSFDLKFGFTRFKIIPCSIYGITNPRSNFTEVLLEFLKPATFSLKPVCYNGRINFVQLFINNDHETNLDVGTELSSKGVCDYEPQGKRKVYSRDELFAINRSFCQQKINSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U559</accession>
    <name>A0A0N4U559_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6324</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U559"/>
    <dbReference type="STRING" id="318479.A0A0N4U559"/>
    <dbReference type="WBParaSite" id="DME_0000196401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000196401-mRNA-1"/>
        <property type="gene ID" value="DME_0000196401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000196401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21298" checksum="9953E259BC7A0A0A" modified="2015-12-09" version="1">MPTKAKGALLKEFTVIGRKLPSEKEPNPPLYKMQIFATNHVIAKSRFWYFTSMLRRVKKAHGEIVSCKEVFEKSPGRIKNYGIWLRYDSRTNHHNMYREYRDNAIAGAVTQCYRDMGARHRAQADRIQIIKVQEIKAKDCKRTAVKQFHNSRIHFPLPHRIQKRRNVPIFTTRHPRTHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U598</accession>
    <name>A0A0N4U598_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trigger_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6371</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U598"/>
    <dbReference type="WBParaSite" id="DME_0000201101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000201101-mRNA-1"/>
        <property type="gene ID" value="DME_0000201101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000201101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13478" checksum="B9DFD8F74DCEE865" modified="2015-12-09" version="1">MVLRENVEVAKGHKALRNDEELAKSLLREVHQRDLKEVQEDKSMIELNLNQLNLDKQWIATLIGNSRGEKAYEKFFDDPSVQKSISEASTLITRLIVKEMQLKLQFEELEKEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U605</accession>
    <name>A0A0N4U605_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6679</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U605"/>
    <dbReference type="STRING" id="318479.A0A0N4U605"/>
    <dbReference type="WBParaSite" id="DME_0000231901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000231901-mRNA-1"/>
        <property type="gene ID" value="DME_0000231901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000231901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44524" checksum="0300450E9984C0C4" modified="2015-12-09" version="1">MNLMQYKFSASNEVVFVNFYADWCRFSQQLKPIYLEASEKFTTMPPGKVLWASVDSDREVDIAQKYNVNKYPTLKLFRHGELVKREYRAQRSVEALSDFIYKQLNESIITIASTDDLKAKMDKSKRNVVAYFNQLTGSEYDNFRKVSSALREDCVFWVGSGTGFENQFANGNKVLFYPPKIDEIVEYKEKLTNLQYLKDWLGDKCIPLVREITFENAEELTEEGLPFLILFRIVGDMNNEKIFNDAVIRELYDQKNSINCLVADGEKFAHPLHHLGKSKSDLPVIAIDSFRHMYVFDKDVSIPGTLRQFVLDLHSGKLHREFHHGPDIDTTQQSVAEKIDPAQQVDKQKHVQIKKFDNTQPPPSVFNKLKPSENRYSLLHKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6A0</accession>
    <name>A0A0N4U6A0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Beta-1,4-galactosyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6795</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6A0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6A0"/>
    <dbReference type="WBParaSite" id="DME_0000243501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243501-mRNA-1"/>
        <property type="gene ID" value="DME_0000243501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30244" checksum="6EC44BBF412BD040" modified="2015-12-09" version="1">MKAMEKVFSMLAPGGHGEPRNCRARHRIAIIVPYRNRPLHRRLFLYNMHQWLPKQMLDYMVIIISQLGKEKFNRGALMNIGFVEAQKLYDWECFIFHDIDLLPENDRIPYRCLDQPLHLSAAMSKYNYSIPYKKYFGGICAFTKEQFLRMNGFSNDYWGWGGEDDDAHNRVLLAGYSISRYPKSLARYTMLPHANQAGTSNASNCYTPSINETLSKWKKSGLSSLNYHLYSIKFLPLYLSIQVTLMDKGQERLLQNSSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6P3</accession>
    <name>A0A0N4U6P3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMERB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6968</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN56995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6P3"/>
    <dbReference type="WBParaSite" id="DME_0000260801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000260801-mRNA-1"/>
        <property type="gene ID" value="DME_0000260801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000260801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12529" checksum="9CCA10651045ECD3" modified="2015-12-09" version="1">MEKYLNELHAEVEYRLRCSIERTKEKNLMEVEYEAKLLELLVEVIDRKNYLIESKFDSSAIIEPKLMTKIKHDKESRQRMKKRLRKLKKRLIFTKESGRKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U723</accession>
    <name>A0A0N4U723_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7125</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U723"/>
    <dbReference type="STRING" id="318479.A0A0N4U723"/>
    <dbReference type="WBParaSite" id="DME_0000276501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000276501-mRNA-1"/>
        <property type="gene ID" value="DME_0000276501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775605at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF6">
        <property type="entry name" value="PROTEIN LET-653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="114"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="212"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000276501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="802" mass="90296" checksum="8AEB032871C637BB" modified="2016-06-08" version="2">MLHITETKGYAIANIPINAKQNCIYVRWQRVKIVFGARSEGPYSFHTCKTACTNDEDPMNKGNQLQCSGFNQRQGPNEYTHHCQLYQADQLQHVDGFFEADDRYNFYWKYCRTCSGDYAYTFLSDRYMDFRVIIRTIHTRSLEDCLSICLNENSFACRSVSFNRTDGGCQLSQHNQLSKPALIKINNNPNYRIDYYENNCFNIADSFVFDYECKDNGILVKVESKYPYTGAMYGLYDFFTCRIEPKDAKKMEYFFPSPTISKNCSDSIRYKGNDMVLEIVISTDGVEPLYFITPDDLTYQARCPIKELGIVNDNIDIASKLTSKGSVDMAKFTAASAHALFTMLSNASQSVVETNSKSDNIIENINCTVITSTPFTTSTTKDLFVLPFHPVEYSTISSIVFLSTTEESTISINTTTTASPEIPLSTLNNSFSDSYKTDDKGLIKNEKSFDEISTMTLPKLNIHFTVLDNQSTIVEKPKEEIHGSEEKSTVDIIPETTSTITTTVDASDRTISSTMDNSLSSTLTEDISESTQSTTESSSTFIEHETSLSTTESTQITSSKFITEYITPNIPTLTDDKLNVTWINAKVPKEAVIFDIFHNGQPVEVVVLGSRITLSFIPYYAIPPAYMSITGCQVEPISPLYEWELEPLAIVKDSCQADHVGLVCPPQKTEYGIQVIVESFRYQTTAHVQYSCLIRICPFAPCPVTTCENVEGCPSNDLLTRTFGLRSKRHITLEQIRAALAANPDLQRQIQLSNRFGNKPLTNSETQQQLIQLGGDHIVKKRLVVVNSEDDLRYYIRTGEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D5</accession>
    <name>A0A0N4U7D5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS123</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7D5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7D5"/>
    <dbReference type="WBParaSite" id="DME_0000289401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000289401-mRNA-1"/>
        <property type="gene ID" value="DME_0000289401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="875"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="906"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000289401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1108" mass="127560" checksum="2F36324B2F23FD75" modified="2015-12-09" version="1">MVPSFRRLTTTNILLVSALCIMLILNLHISIFIWRKRFYECINKANYVLRNFLDIANKQVDLKYENIDQPFSECINLQLTFRDGKVAFFFSLFFRMPLKYFVLVNVPYILLVEGDVIMLRPGHLTPCRCISSSGKLLFPQSNFYFSEQKCKKTGLIIPLKSIQCTVVESPLVNHIRNIFADHHKRRSNLFDSEIRAINHFFLEKLILPSSIIILAIFFILNSDYRHSDDLSISILFVSQMQDNLDDYKYLLWSTDFIYSLGGITTFAFIDKKGLLSWPNATIEKVFCFDSQQSSHSVLIRYVTANEYKLVPRIFDLSIDGDRPFAVHFDDLEWQKYRKCLLPFGINLGLNSCKYYLNCTKLLDHISILFNRSPTTFSVPNCKCACYFSDLLGVNDLLKGWFDISKSASVGFYKRSPNDSILNGLKHRTTVENAFLTITNDSHSLYQHLMVQGTAKLILSASSHVWNGHSMELLTSSDRKKVADFYQRHSMTSYCLTFGYRTVDSIISNQLCENYVDIPLNFSGRMNEQRWTNRRSLSCDSIFVDQFYNNCLISTANDCIKRLFNNFALLGVITMQYQARADVVHLIEQLDQACIRFVYFSKEDELKSRIFAEKLGLEAGWNCHISLASRGKETERFRTSHIEKQEDVANSRLSTYFATMRSPSIRFNQDEVPLLSRYSADLAIAKSFLLDGTDFDIQQTQKPKKIKNMSQKRSNSTSARLSFSFNDEITAEAMPNKAQLPTGIENIRTHLKNVDNVPLLVNLFTDCDHIANRSMIEIMQDYGEIVLVAGSPLNYYNARIFSQGNCSFCIEPQKPARCYKNNPNENESGSVLKSTQLASLLMSISTNVIISSDETVDVMSMISLCRHQILSTRSAFIFFLYCSITLFFLELLSILLFLPVIFCPSQLLLFICLYLPLIALSLILSPYDNRSCLDEIAPKFTVSTRRKSLSHLLSYYLVCFLPSVAFIIFGYYFMLLNFNAGVHNWRFSPIYLDYSNDNIVAARHLISFLILIIFIVLSVSFVHSRQNIWSKNPINAKFVILTIFALFSFDVLSKFSQFCGIFAGVNLVWAIIICLLHEIYKKHQTNLFLRDQRRRKLSFNTKLGMNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7S9</accession>
    <name>A0A0N4U7S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7216</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7S9"/>
    <dbReference type="STRING" id="318479.A0A0N4U7S9"/>
    <dbReference type="WBParaSite" id="DME_0000305701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000305701-mRNA-1"/>
        <property type="gene ID" value="DME_0000305701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="352"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000305701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="84859" checksum="ADC6A5A1BFE6D742" modified="2015-12-09" version="1">MSSNFHTSSKPLKEVDIRPPENTVKGAVKLDPSIGKYVDEEFGIREGSNMTWTYVTFDKQNEVLNDLITRLSVELKLPQAEKNLYALRFEDRENDGAFLTNENRRMIRQGFMLILTASPERYALFILSRLRRAVPQQYGFQSILSELIAVCGDIAFAVEFHRLGGIKLIFEMIESGLYSDDVSVQSQLLQALLILMDHSGLFLWTDVSDIFIAKIAENITGRAKQEDNTLLLSSLSILDLILNSKSESKMVVVLREVPFESLIRHLEKSDERVLLNVLTLMNSLYNKASSDERSIIIEHLLSKPFRLAIENSVLRKCSHLDVGIEQQLITVQRIQFNKLAQKAMRQPSDADIERIMQLKIFNAEISRSPSFENVEEIRADWSCFMNAPPGVLALELIIALAAHHLDSLTKINMENSMRIDGHSWSFPVVTFHLVNMLIDILHIIKEPEEGDRLYVMLFKSDRPFIDLFAVMIRLFHRTWYEMNASDEDIKKVSAIVRKQMDICLRERPETIEKLEELLIHHSYSYMQKLWDGERSAKEAEELQSDAVKELRKHLRPSIVDLIKKNRKNALKNGYTFGKLSKSKSLQKGQQFWHWKLDSNEKTFLYTDCATADGNITADPLTTVKVAVSEIQKIATSTSGDLLLASPKGKKSIVVRGLMLEVGDKPEVYYLVTSDEQIIDMWADGFNALIGVDHLSTEAEQQVDRFLNIELKMRLLHLDRIPNSFQIPPLPSNFDWISSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Y8</accession>
    <name>A0A0N4U7Y8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plakophilin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7288</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Y8"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Y8"/>
    <dbReference type="WBParaSite" id="DME_0000312901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000312901-mRNA-1"/>
        <property type="gene ID" value="DME_0000312901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865180at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000312901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14523" checksum="82CB373E65C2F0CA" modified="2015-12-09" version="1">MLLILETADRSRYFSGTGTSYISRTSAAERSTVDTSSQRYNYRSRSDMGSPRRYASQTLLDGIRPGPSASHIRRDALHTLQKELDTLSRSPDRSTPRGYSSDTGYMNDTFRSRARGYSNYDYHASYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8G9</accession>
    <name>A0A0N4U8G9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CSRNP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS206</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8G9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8G9"/>
    <dbReference type="WBParaSite" id="DME_0000334001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000334001-mRNA-1"/>
        <property type="gene ID" value="DME_0000334001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000334001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20314" checksum="B4F70EF126F7BD72" modified="2015-12-09" version="1">MKEISNALNYPRKFRITIVPLEEKDGSLGDFTFNDQFAPISNWIYAVSQYIIQPSMFHDDDKTFYNSLKPLSSKMRERILKSAGVALDQSEILENNEIRSRRKSCGCNCIQCEPETCYCTLTGINCQVDEPQFPCSCAKSCNNPYGRIAFRSSLVRIHHQQTLKRLKASQKREETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Z1</accession>
    <name>A0A0N4U9Z1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7941</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Z1"/>
    <dbReference type="WBParaSite" id="DME_0000393601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000393601-mRNA-1"/>
        <property type="gene ID" value="DME_0000393601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817643at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000393601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28817" checksum="0475F31B1BB04021" modified="2015-12-09" version="1">MDLAGGNRNSDQNSIAKIRRQSSNSNEIGRNSVLSNSNEIGANPPKKIFRICSEEENSYAEIFENKPTTIKNLIDYKVYRLRYPRRKNWPQKATNVAFKRDTDDLPPREYELFRDFPRSITETEQKREFFQSCQLKGESIQKTTRNWIIVDSIFDLLNENVFKLKNEASSCPGTVLTRAAFPPINFKLFYDALIQVKIQVAGLYVFIAVGHDWSAIPTECPGPTVFTTFIYNFAVRFILNIISLDNSIIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAE4</accession>
    <name>A0A0N4UAE4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8000</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAE4"/>
    <dbReference type="STRING" id="318479.A0A0N4UAE4"/>
    <dbReference type="WBParaSite" id="DME_0000411701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000411701-mRNA-1"/>
        <property type="gene ID" value="DME_0000411701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="13">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000411701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30450" checksum="C50DED02B0B0EBA3" modified="2015-12-09" version="1">MSGKELAEGYVEKMQATSQVTPNPDSATERNSETPICSRNLDEDDIDYVDASYNIEKEIALYWPRVRTRINNLNVMTLREANRHQELPLARIKKIMKLDEDVRHQMISAEAPVLLAKAAELFIEELALRSWLHTEENKRKTLQKCDISQAVSRYDQFDFLIDIVPRDEKRCQQVNKFEKIIAPTSSASIESEIIDCKGFSQQNGNNNSVQYVLQVGPSEGAITSGSMVQATPIGQPIQLPIAPGGQPIQLITLGLPDGNVQQFQVQLPTANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAG7</accession>
    <name>A0A0N4UAG7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS8026</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAG7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAG7"/>
    <dbReference type="WBParaSite" id="DME_0000414301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000414301-mRNA-1"/>
        <property type="gene ID" value="DME_0000414301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="32"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="397"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="741"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="38"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="403"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN58053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000414301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="776" mass="87679" checksum="8F5B59008227E230" modified="2015-12-09" version="1">MSRISVSTSTSESVESIFSENCDDEKISMENFALLKVLGKGAYGKVFLARKVGGHDHGTVYAMKVLRKSRVICKPKTVEHTMAERHVLERLKGLPFLVNLVYAFQSDSKLHIVMEFVRGGELFTHLCSRGLFDTNTAKFIIAELVVAIDSVHKRDVVYRDLKLENILLSEDGHIKLTDFGLSKQLSDNEIQRTSSYCGTIEYMAPEVIHRPSDGYDETVDWWSLGVIAFELLTGCSPFTVDGQSNNSRDIAKRILSKCVPFPRDFDRLAMDFISRLLEKSPRRRLGRKGAEEIKRHPFLADIDWDKCEKKRLVPPIIPTIRNDMDVTNFAVEFTNQVPLYSPADPPMNACNLFRGYSFVSPSVIFSNNNVIGEECLADDFQLLMSTSPFFSKYKLDRTEEGFLGRGSFSVCRKCERLEDGAMFAVKIISQRFHAQATREANILELVSAHPNIVRLIDVVSDSLHIYLILELLEGGELLSRIKAMSSFTEAQAGVIMKQLVSAVSYLHSKNVVHRDLKPENILFENKDTQAKLRLVDFGFARILPSAAEHLTTPCFTLHYAAPEVLESDDQLPQYNEQCDLWSLGVILFTMLSGNVPFHARRKDESATDIMTRIRNAQFSFDGPQWREVSTEAKTLITSLLTVDPVKRLSLIELQNHPWLLDAAAQNETPLQTPTTLMMSHTAETFNETMNAFLIANRDGFHLMEVTAAPLLVKRRGLKRKSGNESVVESNKKSTMIRCELESVPEAVSPEMTRPDTSLMEYRTPKPPTIRDTRDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB67</accession>
    <name>A0A0N4UB67_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS8313</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB67"/>
    <dbReference type="STRING" id="318479.A0A0N4UB67"/>
    <dbReference type="WBParaSite" id="DME_0000443001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000443001-mRNA-1"/>
        <property type="gene ID" value="DME_0000443001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0164">Citrullination</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN58340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000443001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14981" checksum="B93DCAECBBD077E7" modified="2015-12-09" version="1">METDSNIAEKVKNTGRRLPKSGRWWKAVRKERSSAIIKVKPLKSSWERKMKEKADSINVKKLQNEIREKLEAAKAAKIERRKEQEKRKEENARKAEIVQVIRNTSKIKRLKKKQLRFIEKRDTNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBD1</accession>
    <name>A0A0N4UBD1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Solute carrier family 25 member 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8388</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBD1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBD1"/>
    <dbReference type="WBParaSite" id="DME_0000450501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000450501-mRNA-1"/>
        <property type="gene ID" value="DME_0000450501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="94"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000450501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32734" checksum="E65FFFFAE2984F30" modified="2015-12-09" version="1">MVISEEYADFICGCGAGCLETILLYPQSKLIFRQQLHGVFAREAIRQLRNEGFARLYRGLLPPLIMRATSRSLMFGIFGNLEGYFECKKYSSRATFTACYSSAAILAGSAEAILCPLERVQVLLQSAHYHERFYNTGHALKEVSKLGLRELYRGLSVVLIRNGFGNALFFNLREPIRNAVLSLDEKFVCKHERIPMSFIRFFADFVSGAVLGSSISTLLFPLNVVKQRMQSTLNTPLLSARTIFKIVWRERNGSIRGLFRGVHLNYTRSLITWGIANSVYEFLRRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBG1</accession>
    <name>A0A0N4UBG1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8421</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBG1"/>
    <dbReference type="STRING" id="318479.A0A0N4UBG1"/>
    <dbReference type="WBParaSite" id="DME_0000453801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000453801-mRNA-1"/>
        <property type="gene ID" value="DME_0000453801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871657at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.680.10:FF:000001">
        <property type="entry name" value="activated CDC42 kinase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.680.10">
        <property type="entry name" value="Cdc42-like binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015116">
        <property type="entry name" value="Cdc42-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037085">
        <property type="entry name" value="Cdc42-bd-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09027">
        <property type="entry name" value="GTPase_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="630"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000453801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="671" mass="74519" checksum="12D053D8009EB5A1" modified="2015-12-09" version="1">MTAECREVRVPNKEADLEMILDDRIIVIDGSDHIWYGQNVRTRKFGHFYRSCIYAKSNRSGEPNSANFTSGMISENNHNDKISKPIPGSFIHAGHGDINPSQSWGQPDRIDDIYLKNPILRKEKEIFNENSRRRIGPEIIPSIIDVSSRGQSVVSALNAGSGNRANESPNLARDKSLYSVDPFAPFSEYSYEVFNGHVSENVNQTASNPNLLHPSSFDVYDQPPVAVETHVDGLIDSVKNKSNPSQLSVSATVSMHPSENIVKQESPTLANNSKNAENYYLLRRPQSSVVLNSIKSSSSSRFSSSLTPPPIRSINYYNRAENQMLKSEDSSRNLSQDAIFSSVSSENCRNYIGSVISEKADETKISQRPYDIAENIHSICNFSDDQSRINSTNSSVNVEPTPSSASSLFHSSNVCSLYEQSCSATTSVDIAERKEDPFEVPLVVKNIANRDRYSQMFMNTSNDLNSTPMMANCFSYSNPECTTNTPVAQSSYRVPFFWQPPSQSTNPANNLLTSIGTTPTLVYDAQLSAKAIQKQQNSPRNINFSVKRLSVNESTSGEILQPKSSQLIQRKSFINDEVLCMFDPLVSLQSTVNKAEGQNCLEIVMKGATFAGRERCEQMLFKCQNDSAQAIRELKIDELMCMGVAKNRSLAKIALEDCRWNLNDAAAALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBM8</accession>
    <name>A0A0N4UBM8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8501</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBM8"/>
    <dbReference type="STRING" id="318479.A0A0N4UBM8"/>
    <dbReference type="WBParaSite" id="DME_0000461801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000461801-mRNA-1"/>
        <property type="gene ID" value="DME_0000461801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845649at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000461801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19941" checksum="22C508D760A3C3A6" modified="2015-12-09" version="1">MENSLVSIRLIVYLSDNPWDCGCLINELKKHILERYNYRWTLRYDNIRCSTPLQLKDTAVLHLNHISDCAILFGARYGLSQFSEITILFILLVSIAIIASLFIFFIYYRREHKLKSKPKYGDILESQSRIALTLSQHLSGSPSSATEPLTPPLESPLSGISTKIPPPPPPPIIANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ2</accession>
    <name>A0A0N4UBQ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8531</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ2"/>
    <dbReference type="WBParaSite" id="DME_0000464801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000464801-mRNA-1"/>
        <property type="gene ID" value="DME_0000464801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5812977at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000464801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13069" checksum="CE94068964520A15" modified="2015-12-09" version="1">MVENLREVKCLQKTSHCFLEIYRLEVQTWFNGQCDDFAACIHESDYTVEYGCQATFHGGDRCCCRTKNCNFDRILSERPSFRRFLPVDDIKTDEIKKAVKCGKKQEKISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ6</accession>
    <name>A0A0N4UBZ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8642</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ6"/>
    <dbReference type="WBParaSite" id="DME_0000475901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000475901-mRNA-1"/>
        <property type="gene ID" value="DME_0000475901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000475901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46012" checksum="A0DFE683466473B5" modified="2015-12-09" version="1">MLQPGIGDITYAYYIILYFSYNSPLSKGNLSTAVKEGLNNKDFIKLVVWLCGELSALYELDVHAVVEHDDLESFLFELSSLLNELECPVDSLVRGPITERFVSVESRQKLLLFLTGHIPTARLIALQRLQNLSLKQKTAEVEHIEIALKTLGSGPPPPDLTIDQLFNKFRSLVTNQLNKCAIKPRPLFIATLKDPQWLKVEELNVRLTQEYRSRIQLLLKRLDVTIHSFFWSDRIKKMEDEILAIYRPMRDRMLVFSDVHMYDLLAANTDLLNVEKTSNEKLRERTSTPLNKVLMTNRPGDRGGRPSDMRAPPPEMPPWMKERTSEYSRGGGGARYGGGSDHFSSGRSNYHANQDAYARQGSQSFQSQLMQEYGQRYDGRGGHRQFRGGRGGSGGGGYRGGYNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC78</accession>
    <name>A0A0N4UC78_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS481</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC78"/>
    <dbReference type="STRING" id="318479.A0A0N4UC78"/>
    <dbReference type="WBParaSite" id="DME_0000486001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000486001-mRNA-1"/>
        <property type="gene ID" value="DME_0000486001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="13">
        <location>
            <begin position="388"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="747"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="686"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000486001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="979" mass="111099" checksum="BFC9C903EBF687BF" modified="2015-12-09" version="1">MTTVTIPGSLVNKRKKHFLGMPAPAGYVAGVGRGATGFTTRSDIGPARDSTDLPELPPAGAAKKPRDDDDDKKDDTEDLNDANYDEFEGYGGSLFSKDPYEKDDEEADEIYKAVDQRIDERRKEYREKKYKEAIEKYRKERPKIQQEFSDLKRQLSSVTESEWSAIPEVGDARNKAKRNPRADRITPVPDSVLASAMAYGHLSTHIDSRVQSGLVTPLGAGITSTFSGISSTFGSFGSGYLTSLSGIKTSLLAPGWKTGIQSGSGSSADLDLRKIGQARNAIMDIKLNQVSDSVTGQTVVDPKGYLTDLQSMIPQYGGDINDIKKARLLLKSVRETNPRHPPAWIASARLEEVVGKLQVARNLIMEGCDRNPKSEDLWLESVRLHPPETAKSIVASAVRALPNSVRIWMKAADIEEDTKGKRKVYRKALEQIPTSVRLWKAAIELEEPEDARILLTRAVECCSTSTELWLALARLETYENARKVLNKAREHIPTDRQIWISAARLEETRGQSEMVDRIIERAITSLKANMVEINREHWLKDAVDAEKANCKLTSQAIISHVLGVGVEEEDRKHTWLEDAESFVARDAFECARAVYAHALLVYPNKKSIWFAAAHFERNHGTMCVDFFFKGHSQLGSVSLSDSESYDQLLSKAVEKCPKAETLWLMYAKSKWMAGDVRGSREILARAFQLESENNEYQRARKLLEKAREIAPSPRIFIKSVRLEWCLRDLEAAKKLLLRALDDYSDTSKLYLMMGQILSQEKNFEEARKYFTEGVKRCPSNIPLWIWLTRLEESLGHITKARSHLEKARLKNPRNPDLWLESIRLEARAGLEELAKERLARALQECEHSGKIWAEAIFMEDRHARRTKSVDALKKCEHNADVLLAVAKLFWTERKIKKAREWFQRTVKIDADFGDAWAYFYKFELLHGSEEEQEFVLKKCIQAEPRHGELWQSASKDVENWRKRPEEIVKLLAAKLEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCF3</accession>
    <name>A0A0N4UCF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001172">
        <property type="protein sequence ID" value="VDN58772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCF3"/>
    <dbReference type="WBParaSite" id="DME_0000494601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000494601-mRNA-1"/>
        <property type="gene ID" value="DME_0000494601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000494601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8442" checksum="5C8C7CC5EA6E6C36" modified="2015-12-09" version="1">MVILGRDWNERIGHDAVSMNSMIGKYAIRMQCANGECLLHFAKEHELFVKYMLSASEETSNHVELSGQPIFQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD18</accession>
    <name>A0A0N4UD18_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8992</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD18"/>
    <dbReference type="STRING" id="318479.A0A0N4UD18"/>
    <dbReference type="WBParaSite" id="DME_0000519301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000519301-mRNA-1"/>
        <property type="gene ID" value="DME_0000519301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000283">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000519301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25655" checksum="1C0AFB5688613390" modified="2015-12-09" version="1">MKYPGLVYRLKITGPKNINVDSRWTKCESSNRTIYDFEVEDLEGQRRDLNEYRGKILLIINVATFCAFTKQYLDFNPLIEANSDINLEILAFPCNQFGLQEPAENHEILNGLMHVRPGHGWKPHKNLHIYGKVKVNGDDQHPLFEFLKDSCPQTVKTIGKPSEMMYEPIRANDITWNFEKFLIDKNGIVRYRFHPTAWKNGDIVQKFIQTLANNKQTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UED7</accession>
    <name>A0A0N4UED7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9331</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UED7"/>
    <dbReference type="WBParaSite" id="DME_0000573801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000573801-mRNA-1"/>
        <property type="gene ID" value="DME_0000573801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000573801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3793" checksum="6EE91654274EA883" modified="2015-12-09" version="1">MNAFYYLEKKIVENILKHIFVVCDRMVLKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UER5</accession>
    <name>A0A0N4UER5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9411</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UER5"/>
    <dbReference type="STRING" id="318479.A0A0N4UER5"/>
    <dbReference type="WBParaSite" id="DME_0000588701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000588701-mRNA-1"/>
        <property type="gene ID" value="DME_0000588701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309339at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000588701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21403" checksum="378337FA8535003E" modified="2015-12-09" version="1">MPIIFKILRVAAEKCSYNGPLWNNIGMCFFSKGKYVAAISCLKKAIYLCPLDWKINFNLGLVHYAMQQYASAYHFFSSAVNLNPRSSIVYMALAVILTSLNDPINARKAYEKAILLDKNSTPQLYLNFALFEAKQGNSDKAMEYLKQFENMKRKNFILPQVCHCLKSLLSKNQNCRYSHRLNSAHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UET2</accession>
    <name>A0A0N4UET2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS845</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UET2"/>
    <dbReference type="STRING" id="318479.A0A0N4UET2"/>
    <dbReference type="WBParaSite" id="DME_0000590601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000590601-mRNA-1"/>
        <property type="gene ID" value="DME_0000590601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000590601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="47500" checksum="A360B116BA07D731" modified="2015-12-09" version="1">IILTVVINIAFAFKWILGSILGLVHACFVHFSYLKVSMPYMDEIFHVDQTRRYCIANYSWNGKITTPPALYLLSVPFFCGNERYINSFLICFAFVGLCNYRRLFTSSQVFLTSILSLCLPVLFHSSILYYTDLLSLTTLLWALSSKSSLKAAIFFTLALLTRQTNIIWAGMYVLIYFIKNVDDKNLIGSIIKIFLDLWSFILLFIAFMSFVIMNDGKIVLGDHEAHRIVPHFMQLYYFSLFVLIRKILFMPIRTFVLCGVITVCIYCFTMDHPYLLADNRHYTFYIWRRFFLYHPSFKYLLMPIYLISLYIMKEFTVHLSPSNILLFLLSTASVLVPAHLLEPRYFIASFILWRMALLENRRWVLIIEFLYLLIINSLTLYLFFEKPFEWLNEPGIKQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFB2</accession>
    <name>A0A0N4UFB2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1051</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFB2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFB2"/>
    <dbReference type="WBParaSite" id="DME_0000611201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000611201-mRNA-1"/>
        <property type="gene ID" value="DME_0000611201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857768at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000611201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="52140" checksum="585359450D90129E" modified="2015-12-09" version="1">MRLLPSNLLLQIAKKQLQFEEHREIAKQCRDEAIRHKEEGEHWKKEYNRLLDMYKRKDADIEKLKKEINLFKRNQKSKESEIEPLKKRASHLQKIAERSQKKKLEDIIKEKDKLIEKYELNKQRLEKHLELSIAKKAHERGNLALNALHSQAVNRASNKAPICAATKIKYIRNDDECAENEFGNMNRGRKIVHWNEPLATAIAPSTAAAVSLEPNADMLLTRSEKNIFGCASLYKGSNGDFTVYTQTYCGCHCYEYSNTDVRWIYRNKRFMLYYYGQARSTTLEINYGETIIRHFLIGRLEIYRKSNETTLVMPCGRRIETIRRPNSELYTEIFEEDGTVSTFHPDGTKTKRLASKISSERCDGSKVSLVNNDSFAWISKDYTVRRFKNGDVKVRLNNIDTSIAMMMVDAGTVKHLSGHATGPNRYCFEWGTKARERSRLAVSRVLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFC0</accession>
    <name>A0A0N4UFC0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1061</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFC0"/>
    <dbReference type="WBParaSite" id="DME_0000612201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000612201-mRNA-1"/>
        <property type="gene ID" value="DME_0000612201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849338at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000612201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17631" checksum="868652D6A9A4282A" modified="2015-12-09" version="1">MLACALCVANPNACRNPSWYTNFCFLLQAMYPEPKGRSSPQMSELRSRIIAMQAVGIDEKSVEQPRLNQVAGNRATVAMLAPAVHIMHQIWKGMAWVTDGIDEDDIHLRNTEQEIATNSVYRETSQQTTSKIELNSASQKPQTVSSDESFNSKNDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFM3</accession>
    <name>A0A0N4UFM3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1143</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFM3"/>
    <dbReference type="STRING" id="318479.A0A0N4UFM3"/>
    <dbReference type="WBParaSite" id="DME_0000624601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000624601-mRNA-1"/>
        <property type="gene ID" value="DME_0000624601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000189">
        <property type="entry name" value="Member of ras oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000624601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19864" checksum="4717879E2A8EF61D" modified="2015-12-09" version="1">VVVLGSGGVGKSALTVQFVSNTFIEKYDPTIEDFYRKEIEVDGQPCVLEILDTAGTEQFASMRDLYIKNGQGFVVVYAITSQQTFHDIKTMRDQIIRVKGTDQVPLLLVGNKCDLVHQRQVRVEDGLSLAEYWSCPFTECSAKNAHNVNTVFAEIVREMNYVQNTRAKQNQGCCAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGM8</accession>
    <name>A0A0N4UGM8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGM8"/>
    <dbReference type="WBParaSite" id="DME_0000665401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000665401-mRNA-1"/>
        <property type="gene ID" value="DME_0000665401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877512at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000665401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24439" checksum="4B65625C69B7EAAD" modified="2015-12-09" version="1">MTLHIPVKVHTLSNHLSRQDRLRISTTDKRFRNRSLCSMLYTPPPYPGYSSVLSSIRKSNDAALSTPNPLRNTSNRVCTYHILYPENTSSKLSALDFDTSLVDDTKLIELCSTNPRKTTPASKESSGYGSVSSESDPENDQHAVEDETNENKRSLGITPENSKVCHKSSKLEKGRRKSVPSYLRETFSDEIFRILEIGGIIQYETDVVSIFDSFGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGN4</accession>
    <name>A0A0N4UGN4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPA_interact_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9687</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGN4"/>
    <dbReference type="STRING" id="318479.A0A0N4UGN4"/>
    <dbReference type="WBParaSite" id="DME_0000666101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000666101-mRNA-1"/>
        <property type="gene ID" value="DME_0000666101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028159">
        <property type="entry name" value="RPA_interact_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14768">
        <property type="entry name" value="RPA_interact_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPA-interacting protein C-terminal" evidence="2">
        <location>
            <begin position="509"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000666101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67201" checksum="92BD1EA0E4BEFAFC" modified="2015-12-09" version="1">MVSTSHFNAGTNPIAFSNIPLSSNQAILNEKSSEHQFSYFSSYLRKFADKKEPTKGSKQKTNLIPNRDIYATRRMKTGNLPNTSKPNTAAIKYLEKDSRNRKMTAKEKYVDYARRFFQKNPAMALWTGANNRANNTKKGFLGDELLQWQNHESEENNLARVTEDNPNVIPSQSVIEDHDKSVSVTSSNKSVYSTSRINEWSDLAQKVTAVLTTSKEKVDDEKYFNSAIHPSCSVSLLYSSQQQDINIFTSQQKNIGSHIQSFCYPLGSHHQNEYQAIPFSSSNMNLQQIPTVQQPYPFITAYPQNLYTQLAAVEQDQMQCHYSSASATSQPAGMQVVQPSTNVNIAQIPVTQYSSQPTTYSRPAISSIYNPLEPNYGLPNTAQAGYNGYFGYHREQPAYQQYFPPYHVQPSEYYGSKCRELSRERRLKKANTIRGIDLSFANQKYTDVISEELIPVQHNSTDNNDELLANIEQLENLREDLVQEYEHLLQVEYERIEAEFASYLDEQVICPSCQKNSLTFPNSSSISCGKCNYIIYLSSYITSPNMLLEHFTEIFTKHWEFCREQLIVVVEQNNMLTNCSKCGFSVQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGQ5</accession>
    <name>A0A0N4UGQ5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxiredoxin-like 2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Redox-regulatory protein FAM213A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9715</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGQ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UGQ5"/>
    <dbReference type="WBParaSite" id="DME_0000668901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000668901-mRNA-1"/>
        <property type="gene ID" value="DME_0000668901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850315at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF31">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000668901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18947" checksum="4B691CA6E07512BD" modified="2015-12-09" version="1">MILKAGDLFKKHPALVMAIRRPGCILCRQEAASLSTLKPILDKSGICLYGVIHEIEGVEGFKPYFTGEIYYDEEKRFYGPKERWLPLWIGFLRPSLYFRYQNAKKKGVIGNIEGEGRLLGGIFLIHKDRLAYAHFEEDWGDAADLDEVLKAIEEYKKNVNGYICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGQ7</accession>
    <name>A0A0N4UGQ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9717</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UGQ7"/>
    <dbReference type="WBParaSite" id="DME_0000669101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000669101-mRNA-1"/>
        <property type="gene ID" value="DME_0000669101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF31">
        <property type="entry name" value="BESTROPHIN HOMOLOG 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000669101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30553" checksum="B52F162E29A75A10" modified="2015-12-09" version="1">MLLFEIQAAIAWSGVSVRTLKRFPTERHLVETNLMTEEEYSLYMSMDAPHGKWFVPIMWIINLIKTMHRQKRIDSVHFDMIMRQIYLFRDGFAMLFVYDWIKIPLVYTQVVAIATYGYFVICLIGRQPKLDQRSMEKEITILFPIFTTFQILFYIELNYVLDRNTCIANMIATDLADQLPSISKQTINITLPHTRASFKIQDVIPRSHLSNLKLSENEMELIKPEELEESSDIVQKKNARLRSIVRGIQNSTKLFVFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGU5</accession>
    <name>A0A0N4UGU5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RGM_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1347</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000019">
        <property type="protein sequence ID" value="VDN51374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGU5"/>
    <dbReference type="STRING" id="318479.A0A0N4UGU5"/>
    <dbReference type="WBParaSite" id="DME_0000673301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000673301-mRNA-1"/>
        <property type="gene ID" value="DME_0000673301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871443at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039206" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000673301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13735" checksum="BEA079B4168EC308" modified="2015-12-09" version="1">MRLNIIALVVVEKFLQVCCQCADELQGCAVITEEYESEIQNIKAAAFAECFANPTCNYEKQLFQECFIRSVRAIRAPFNNEDSGSDSFGDSAQRYRGAVDQCFIKSNVKRSGHFDASAIFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGY2</accession>
    <name>A0A0N4UGY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1387</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGY2"/>
    <dbReference type="STRING" id="318479.A0A0N4UGY2"/>
    <dbReference type="WBParaSite" id="DME_0000677301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000677301-mRNA-1"/>
        <property type="gene ID" value="DME_0000677301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007451at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Axin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF2">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="4">
        <location>
            <begin position="428"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000677301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58640" checksum="3DD98ABFF10C5FE4" modified="2015-12-09" version="1">MMSERIRSLPAYCLPKVTLFDPCIEHVFNYLRKQHASWINSERFKQLRFQCVAKRNEFVPSTSACGDFVFSSNKGISAVNNLAYEVVRKNSRLKLQKVSQNFSGLTSTISNKDHSATSSSSDECHGRVRKKSVDRNLQTTAMMDGFDYRHDRPEERERFAGVLKDKLQHMLLELTTTSKDSTESFVTLGSSHKSVANSVFLLDHEDEIDSLISDSDDSVVKYEKKLSATIDKNSREEKHRSGSTSPIRFQPSLENRNSNPYGHNKFAPPPGGINLQRCSTLSTCSKIVRNETPISRQIEFPISFQNNFRDFALKAKKGFLICTDNPGNDVQHLSDSSGFCSSESANIVNRAALFQKARNMASQAIFLSQDCEMRMDRRTSYPPLSQLSNSTLISLVFFITRYHNIFREVGRCSNPTKRRNELESLYLSKPLIITYQEENSEAPFVAKISGRGITYRDFRRYFGIPSRTSKKFFFKSECEDGSALYQWTVISDDNMVLPVFEGRITAECRSFSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH70</accession>
    <name>A0A0N4UH70_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1489</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH70"/>
    <dbReference type="WBParaSite" id="DME_0000687501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000687501-mRNA-1"/>
        <property type="gene ID" value="DME_0000687501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835206at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000687501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10313" checksum="BACD192DA933DB7D" modified="2015-12-09" version="1">MFRTTFYQQCSTAICLNNQRLSAYVQVISNELFFRSPKWSRLSPSGGSLVSGRGNFRPGFLSRAVGNRVYLADPLLAFKRSESINDKNPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHD9</accession>
    <name>A0A0N4UHD9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1543</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHD9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHD9"/>
    <dbReference type="WBParaSite" id="DME_0000696401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000696401-mRNA-1"/>
        <property type="gene ID" value="DME_0000696401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5791600at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="369"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000696401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="59592" checksum="8DACC0687A6CF307" modified="2015-12-09" version="1">MRLVGLNGPSRRAPEIELYKTGLGCKSWMDCTLYNDSVCNLNTKLCDLHSGNEIHDFFLTFLASNGTIDIPNLDENSTTLLSNNSHGSIVDSDINNDVKAKVGRNLKFLAKAVRLQRCLRENGVVNWKNWRNSMQIPTQIPVQCRENIIFMCHSKRVEILLRLEPPKDPLQPEVKIFSNTTNKMELDSCKTQIIYICICLKCNDFLLDRWFDEALGFWTNETKESYELAQILYGKTLLIGCGIRKCPRTEVLVVCQYWPKAIPGSLYRQGSSCETKDCCNTYNQSSCRSEIGLCQIPSDFAFPDPLHAVKLQATHITATRLPTDDCIGTKLPSTYPFQFKKKHKEYRKNASGIISLRNFEHYEEEFLFQLDWNCELEKKAQTEAEKCAEPPRDAKYKYHRTIIHNFEFGDLTKFLDRKIDNAISRWWGNVVNNDNVDVITTEMGCGIATCVDESLQMVLDIVCHYWPISDPNELYSYAISCARNRDCNSLPNSFCDTDLEICVEAEHKAKFSVSNYRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHK2</accession>
    <name>A0A0N4UHK2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1589</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHK2"/>
    <dbReference type="STRING" id="318479.A0A0N4UHK2"/>
    <dbReference type="WBParaSite" id="DME_0000703701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000703701-mRNA-1"/>
        <property type="gene ID" value="DME_0000703701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13153">
        <property type="entry name" value="KOW_GPKOW_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041994">
        <property type="entry name" value="GPKOW_KOW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000703701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54933" checksum="64A9436E6788E451" modified="2015-12-09" version="1">MENICELRSSTSGQKVSFGVKRKIESFNKSINLLKGNAEDGDGDEILHEQLNKKQKLSFVDNTLFANEKSENSLLIIPMVTRKDWRVEKILKLKEQSELNSEDDAKFQSLFPNLSKKFKLLRYCNAENSSTAGDSLLNNSFPEDADYNLIPVESFGLAVLRGCGWKDGEGIGLSNKKVVPLKIPTKRPKGLGLGADISIKKPNSKVKNGEKDFQVLKKYSYVKVINGIYRYQTYFIYLNLNLLGAFDSYGRIEGFDEDNGSVIVQLALSGNNVRVNQYALELISVREYERNYALFFKSHPEGKIMEKTGQKIQLVKKKDYMNQNSSIYKCSKKELPKSGDCSSSRDNLTQSNNRIWVQTGLRVRCISKRYKTGFLSVFLFQNGSLFTEKVKVIDVPDSKYCTVEDFSGRVHYDLKQDWLETIVPKVLGAKVLVINGIWRGSLAVMEAKDKHRGEVTIRILSSDDVITASFDDICEYTGLDYDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHR1</accession>
    <name>A0A0N4UHR1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHR1"/>
    <dbReference type="WBParaSite" id="DME_0000710401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000710401-mRNA-1"/>
        <property type="gene ID" value="DME_0000710401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412006at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000710401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10986" checksum="28068A52564865C4" modified="2015-12-09" version="1">MGILLSIKAVKVVSDDGMNFLKPNLTMPSVVPNITDLPVEPYVCNCEPPTEKEILSVILKLKANKTSGEDGLWSEFFKSYPPSFITHLQCILWYGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI76</accession>
    <name>A0A0N4UI76_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1713</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI76"/>
    <dbReference type="WBParaSite" id="DME_0000729501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000729501-mRNA-1"/>
        <property type="gene ID" value="DME_0000729501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000729501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8105" checksum="4B5E168138F2F27B" modified="2015-12-09" version="1">MLLAFLIVVSDTSASDEQLNVEEPQRTIHFYCAKKCEAELGENIPDVRLEQYCRLQCKYYCQQLKEKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIR6</accession>
    <name>A0A0N4UIR6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calx-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1778</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIR6"/>
    <dbReference type="STRING" id="318479.A0A0N4UIR6"/>
    <dbReference type="WBParaSite" id="DME_0000751101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000751101-mRNA-1"/>
        <property type="gene ID" value="DME_0000751101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19438">
        <property type="entry name" value="lipocalin_Blc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000019">
        <property type="entry name" value="LiPocalin-Related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047202">
        <property type="entry name" value="Lipocalin_Blc-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF1">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042854" evidence="1">
        <location>
            <begin position="18"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin" evidence="2">
        <location>
            <begin position="335"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000751101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="55937" checksum="E37C9B558F5828DD" modified="2015-12-09" version="1">MLLVICLLAVDILGIKTELSDTPIVIRLQPQLHPPNFVKEMSPPRIVDSPVQASSNIEAFVAREMSTIPPPPPISIPPDVQNQLIKFFGLDSFGIPGLTGNHPNGFAGAIEELKAAGIPIQGLPFEHITSSTSNKQTNDLNVQPNSVFGNQVNQIQNEVASTNYRGTSDLKLPDDNPGKNGLIGFLSSSFRKLVQDTGVADALSQGIPSVLGTSSDSAIASSHDSAAADISNRYSSGNGVRRQQSAAQKVLSGVAAALGSGGPKHAGLPRIPGLPLLPGGIPRNEHGQIDVVQLIGSITRRISNGTTLADIIPPEQLQTLADNVTDALLPSTPENFDLTKFMGRWFEGINSPRATEQRCVVHHYGGLTKNDRTATFTALKIYREGSEFGPVRYSIGYAFRGGNKDAMLQLHSSETSDAQPFWIYHLGSEGKDPFGNPQYEYAIVSNWVKYPVTVLVRDPDRFRVKYEKEVLRWLEDQGFINGFVRAFNMLQPANYNSCQYADSTFEVFGPSKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJA6</accession>
    <name>A0A0N4UJA6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1949</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJA6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJA6"/>
    <dbReference type="WBParaSite" id="DME_0000773101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000773101-mRNA-1"/>
        <property type="gene ID" value="DME_0000773101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF315">
        <property type="entry name" value="NO LONG NERVE CORD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="229"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="406"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000773101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1469" mass="165574" checksum="4D292F50502CC218" modified="2016-06-08" version="2">MTWEYRWFPAFHHKMTKRELKQIFGVEHHSQVPDYKLVKAEKQIVGDGELLLSFDAWNTSYRLELIPNRRLISPHLISVVRQGNETYTTKGLPLNLQGNCHFHGKVVSHGNVSAAISNCKDLMGTIMMDDHFLLLQAIPKRFKSDQEADHIIYKRQASLLLPWEKTLNDELYRFDSNDLVFDKFCDINDSIDEPSGSKKFEAEEAYSKYKIPPESKLDSLYIFPQMDPLTIELALFLDSKLFEHFTREYEQDTEQHLVDFSLALINNVHMLYQQSSISPNLEIVIVRYELWKTQPIGLETASNRNGHARLMLNLFSQYQAFYNVGTDLTDDEHWDHAVLLTGYDIYYTTTAVAGVATIGQMCHHLHSSSLVEGIHLGRSFVLAHEMGHKHVSDFLGMSHDGEHNMCNPSCCLMSPMNGAGRTTWSPCSLREFNAFLMQLDAIHGNCLRDSAVGLEDYNHQKDGRLPGQRFTADQQCSYFYGRDYQLQLPPGKDMSEICRVLWCGSNGSPRTTAHPALEGTSCGVKKFCLEGKCRNWINGKAPEPIDGQWSAWSGQEKRCPISQCQITGSIHIKGQIRTCTNPAPNNGGRTCHGSKVRGLLCKESTSYCKLYSREKYGNIVCSESKEKGDEPDSQLTGYAFMREAKWLDRFLFDLLFTKTAMNSKKIIDASQPCKVWCHLKGTELIRNKGLYPDGSPCGAEKYCVGGSCLILSCNKSALIFDQADCPTEDDLAFLGWGEWSRWTKCSVSCGLGGVQQRTRPCNQNSCAGAKEQSRSCEPHPLECPRTEYTEWTEWSECSTSCGEGQRRRKRSCIGATTCAGNSSEIEFCKKNDCMVESWGSWLTCSASCGMGFQIRERFCNNTVCSSGEKQARICSEKECIKYENIYNWENWSEWGVCSKTCGEGVQSRTRKCQKGHCPKSDVVTEQRHCVLRPCPQWSEWSSWSECMSCNKSEKRQRARQCEVGIIRSGEPDLECSGVSHETEPCDCNLLNFGRNPNNFTNTVESIASTTDKYDKDKIWNEWQSWQPCTVSCGGGARLRVRTCRMTEIACQSIGVQLDAEVCNQKSCDDAGMWSEWNHWTSCSATCGGGMQSRRRKCKATFVFLCDGISEEERQCANDSCTFELIGNISVSLKQYFIFPFSFCSKLPIAITKFLEPHWSTWSSWSKCSCFTMKKFRRRYCQIRDPSLQGFCLGPIIEEKLCVPSTCESESGGWSDWNSWSKCSQNCGATGYRIRNRMCSNPIPSNRGSYCIGYSFDQGPCFPANECKGTPVDGSWTGWTQWSTCSDGCANGHQSRSRYCANPRPLNGGALCIGSDFELSPCYNSTLCSNSIDGGWNEWSPWSNCSATCGFAFKSRQRQCNSPNPIGSGKNCYGLAYMTSICDTKFCEDSVDGQWSSWSEWSACASICGRNTRMRERECTSPAASNGGYPCFGRSSEVSDCKLNQSTAFDQCSNFIHHIQLLDSKSLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK39</accession>
    <name>A0A0N4UK39_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2188</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK39"/>
    <dbReference type="STRING" id="318479.A0A0N4UK39"/>
    <dbReference type="WBParaSite" id="DME_0000806301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000806301-mRNA-1"/>
        <property type="gene ID" value="DME_0000806301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="12"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000806301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61973" checksum="10AA1A641546ABDE" modified="2015-12-09" version="1">MSSRNRKELISLFDVFCEVGADFGDGVAVILQKYPEDFNDQQALKSIVQFTFPCGLHSDEVEAVQLFSFVLTDEKSEYTFAYCRYAPLSNTCLCILSGYSWFSIFYKILNHISMVMNNRPASDLESLLAHMYHVPLPSPGAKLILESGAGENKLEVVVPDTKKLPTLKEDKFMLEFYNALPEKQMIALYASMLKERRILFTGRKLSQLSSCVLAASTLLFPMHWQNVFIPVLPVSLVDMIMAPMPYLIGIPKKTFLSVRKDVLGDVVLIDLDQRTMQNPHNDTSDLPSDVISLLRHELRSSSDLFLSDGLARSFLRTNAFLFGGYRQGFYYSSSYKWNGEKFIQNQRNSLKTFLRSLIGHDGVQYFERFIDERLSALNAGQPVDDEFEKQARLNEEKNSKSSNLVRENANDMFGVLKDKVQSIGELKIKDRFGRLTPREFKKTSSKKSSAFNDVIMSFDTQQWSTDAIPLPSTVVSSSDNNAEDLIDLSDDKSESMINTSVPSSNATTPYPNPHLFTFDPLSHLSSTSESASDNKTAARNQWQRFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK73</accession>
    <name>A0A0N4UK73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10237</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001208">
        <property type="protein sequence ID" value="VDN60264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK73"/>
    <dbReference type="WBParaSite" id="DME_0000810101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000810101-mRNA-1"/>
        <property type="gene ID" value="DME_0000810101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039227" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000810101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7282" checksum="B6CF80748C6AA4E1" modified="2015-12-09" version="1">MANILLASLILLSIEFSSSDDENIKDCATADANPRPTIPPEHCQDVNTNECAALFPLGGQQVLDNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKP7</accession>
    <name>A0A0N4UKP7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxaloacetate tautomerase FAHD1, mitochondrial</fullName>
            <ecNumber evidence="5">3.7.1.5</ecNumber>
            <ecNumber evidence="2">4.1.1.112</ecNumber>
            <ecNumber evidence="9">5.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acylpyruvase FAHD1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10340</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26168"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16854"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19009"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57278"/>
            <dbReference type="EC" id="3.7.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>acetylpyruvate + H2O = acetate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16097"/>
            <dbReference type="ChEBI" id="CHEBI:15360"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.5" evidence="5"/>
    <dbReference type="EC" id="4.1.1.112" evidence="2"/>
    <dbReference type="EC" id="5.3.2.2" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKP7"/>
    <dbReference type="STRING" id="318479.A0A0N4UKP7"/>
    <dbReference type="WBParaSite" id="DME_0000832301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000832301-mRNA-1"/>
        <property type="gene ID" value="DME_0000832301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047621">
        <property type="term" value="F:acylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="14"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000832301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24176" checksum="FFD407EC3CA1C034" modified="2015-12-09" version="1">MANSLKNFWQIGKKIVCVGRNYKDHALELGNVVPRKPIFFLKSTNSYVIEDQPILIPPGCVNLHQEVELGVVIGKLAKNVKSVDAFDYIGGYTVALDMTARDLQDEFKKAGNPWFIAKSFDTSCPITKFIDVKEIIDPHQEELFCKVNGKEQQRCKTDKMIFNIPFLLEYLTQYVTLQTGDLLLTGTPAGVTQVNSGDILEFGLEGKLRAKYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKT0</accession>
    <name>A0A0N4UKT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING finger protein 113A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2366</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000057">
        <property type="protein sequence ID" value="VDN52393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKT0"/>
    <dbReference type="WBParaSite" id="DME_0000836001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000836001-mRNA-1"/>
        <property type="gene ID" value="DME_0000836001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000836001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37146" checksum="ABB5FF5351257F8A" modified="2015-12-09" version="1">MFRRRVRGKGTSSRQQCQETDSSDESADGSVVVGLQKKRRININVSSTKKLKKTSDDNDDSESSSEKAEECVDKLHIAFQSSGTAERAGPSDMGATAINEVETEESCDAQAQFERVQRALKEGHDEKIYKGAAMYGAKEKKDTAIGNASSKWNRIGPMRAPNFIRQSVRWDYAPDICKDYKETGYCTFGDSCKFLHDRTDYKHGWEIERDYASGRMKEEDDDKYLINSSGSDEDDSNLPFKCLICRESFKNPVVTKCKHYFCENCALKHFRRTSKCYVCDQNTNGVFNVAKELIAKLNQKGDHQEGAELLHSSDNEIHEDRGESDSGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL47</accession>
    <name>A0A0N4UL47_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2477</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL47"/>
    <dbReference type="STRING" id="318479.A0A0N4UL47"/>
    <dbReference type="WBParaSite" id="DME_0000850201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000850201-mRNA-1"/>
        <property type="gene ID" value="DME_0000850201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16524">
        <property type="entry name" value="RING-HC_NHL-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000037">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="897"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="944"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="846"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000850201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132693" checksum="F79AA058A023754D" modified="2016-06-08" version="2">MTSTQSGNSKNGDNSPSSSNTLNSDAPLDRIRQILLTPPSTRPPEFENPLEKIEQLLTCPICFDRYKQPKLLPCHHTFCQSCLENCADIVRRILKCPECRAEHPLPYDGIKNLQTNYTLIGFLDVHIQATDDNAEQLEAYIHRYNLERCKICDEKAVLEVCAHCERRACADCRNTHMDMLKRDLSRMLNQVKRLSSRIIEASDGLSKGADLLTLNCETAKDEVHEYFRRYYRELKKREDMFIQEIDTFHANETRLMRNLRDVLEIEISNVSEGCTYLEAALKGEREVQDTEFAKLKNIFGDGLEYLRNFQVLPDADELFSKKLRFSPGDDASKLPNAIANFGELTVSLPQFAGRYLPLEHSYLPRPMRIGYESDNCKFSRRNDIDDNRSQSDARSLMRHSRNNDDDIISTRLRRRQIEEEAWNRLRMGNLDNGRQSPNNYIPGNNPWSRSVVPNASAISNENSSENRNNPCTFGATENFQSHNQGSFVNAFESTQFLPEQPTVLMVPTTDRVQRDKEITELKINNITKAFVKSQETNVAKNMKNVTQNMTMTRQRRTPIPTIVNTPNAQISIIETQPSSHTPTFETNQVTNLTNNENIDPQIATGTCSKMSHKAPLPRQFSSDDMSLNEKIESIRAAHEKRRELKNIESLPEQATKTTIVIHSSEESESDNDQSPPVLTGNRFRIICRSQTSIDSSFLPKLESKLTKNEIINVTASPSPNNVPVLASVSELTAPACSESAPSPIPIQHYPGETPSWLARRRQRYQRSKTNPDLASAIAALSSHASSFSSAASPNTSRIQQLLFERSNRLESSLLQRFQPTLRQESLENSTSEAATTNTQTYTSNIDISTSACSDRRSRYRKRSSAVEREKSSDARISLMRSPRFICSIDYQSKNKPKFVFGKKGSKEGELNWPRGITTISGNEFAVCDSSNHRVCIFNTQGRLIKIFGKYGTGDGELDSAADICCNRMKQLIVSDRYNHRIMIFDQNGQFIRKFGGHGPSNGRFNNPWGVAIDDSGLIHIADKDNHRIQIFDLKGQFLAKFGITSASHEDLYSPQFIAIHKRTQNVYVTDSSNHRVCVFDHNGNPLFQFGQEGYRVGEMKNPRGIAVDEQGFIVVADSGNNRVQIFYPDGRFMYSFGAWGTAPGQMKGIEAVALLEDTIIVSDRENHRIQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULZ0</accession>
    <name>A0A0N4ULZ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ligand-gated ion channel 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS10493</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001220">
        <property type="protein sequence ID" value="VDN60520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULZ0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULZ0"/>
    <dbReference type="WBParaSite" id="DME_0000883701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000883701-mRNA-1"/>
        <property type="gene ID" value="DME_0000883701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000061">
        <property type="entry name" value="Ligand-gated ion channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="61"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="278"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN60520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000883701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="66522" checksum="6EF9A953D42D9DF3" modified="2015-12-09" version="1">MLRSFIESILLSFVKYSIEYNFKLFLLESLRFLSQKNFKNYSKKIKIKNKYIEAIADGAEEMLYKLLLNPQYYEKDVRPTLHHTIPTNITFGFLLNQIVEMDERNQILTTRSWLNINWMDPRLKWNVTRWRGIKTMYVPYEKLWKPDIILVNNAVRHYRDAIVSTDIMTTNDGNITWLFSAIFKSSCQIRVRYYPFDDQECELRFASWSHDITEMDLNLVTDKGDLSSYMNNSEFDLLEMTATREIIKFPINPSKDWPVIVIKIHMHRRPLFYVFNHILPCVLISSMAILAFLMPPETGEKINMCITTILSMGVYLQSITESIPPTSEAVPLIGMYYVMSLFMVCFATFINVIILNVNRKGITNQGKRISWWMEKYILGYMASFVRLSIREPNTITILKMPQDKNSRRYSTIRSWKSIRSISKPKRQNDSNCPCEHFCKKVNFNDKFNMIVIKNAKLIKYLNQSSQRTSDTSFIRMDENRPKILSDFETRFRSILKDIYKSLQQYEIREEIMDERKRIMWQWRQLATVVDRFLLVLFFFATIFIIAFFLVIPATISNPQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM08</accession>
    <name>A0A0N4UM08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2719</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000076">
        <property type="protein sequence ID" value="VDN52746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM08"/>
    <dbReference type="WBParaSite" id="DME_0000885901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000885901-mRNA-1"/>
        <property type="gene ID" value="DME_0000885901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000885901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="4412" checksum="1CF06579F1F33C17" modified="2015-12-09" version="1">MKIFKLKQSICQRFYEIWQQSIDTMNVIKMAKKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM23</accession>
    <name>A0A0N4UM23_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maintenance of telomere capping protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10513</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM23"/>
    <dbReference type="STRING" id="318479.A0A0N4UM23"/>
    <dbReference type="WBParaSite" id="DME_0000887501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000887501-mRNA-1"/>
        <property type="gene ID" value="DME_0000887501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4968544at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026534">
        <property type="entry name" value="PRRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276:SF2">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000887501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40544" checksum="0ED08E455C710260" modified="2015-12-09" version="1">MLKDISITLPLKRTTPVIQHTSSIPPQLHPFPQPAITIVTPCLDSAINSDSPAVSAYESKLINGNVPMEPIVERDDAISFVKSGQQKPIAIGLSEIKDQLDRLEENKNSGGMLSWIQNTVKQSNFLSEVANKAKIGMGSVLTTLDPGMKDFFKIENALEVVIFNDNHRIVSAVVDGFRRVFSGLNYQMIGTSDIDKFKPQVVGYELAHKYIDERLFNISNSGFVISDITIVVIQPFLHFIKGKWYDSSIIAAQKSEIKHHVYTQPVPVSDKVITALKVFLVTVHKTDSFLPFFILHVVYNVILYLQAHTPLDYELNAFTTTVGNGYGEVFGVDPDDWQYNILSFSSSELYTMASTVLASLLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UML7</accession>
    <name>A0A0N4UML7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10605</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001228">
        <property type="protein sequence ID" value="VDN60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UML7"/>
    <dbReference type="STRING" id="318479.A0A0N4UML7"/>
    <dbReference type="WBParaSite" id="DME_0000910101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000910101-mRNA-1"/>
        <property type="gene ID" value="DME_0000910101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000910101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25959" checksum="4807FCE784EC2558" modified="2016-06-08" version="2">MALPPRFPGLIPGYGVQIPPMTTFVSAPSIIDNNKLQPQEKPPVTTVFVGNINEKCTNELIRSILNECGAVATWKRIQGSNGKFQAFGFCEFENPFGTMRALRILHDYPLAEKKLVVKIDDKTRSMVRDFVTKKRVEKGLMPETLAVDELPADEENLAEDEEVRQKILNLIEGDAPSLLPIEGEIKFSKWFRFMEGELEEKTHSPVSDKSVGRERKDRSSDRRREKKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNJ4</accession>
    <name>A0A0N4UNJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3154</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNJ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UNJ4"/>
    <dbReference type="WBParaSite" id="DME_0000947701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000947701-mRNA-1"/>
        <property type="gene ID" value="DME_0000947701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF168">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="342"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000947701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54605" checksum="3400F97929A0244F" modified="2015-12-09" version="1">MEIQNPFQIIWENSSNDFAAFFNAKFAKYGSQLAMIDLEDGKQWRYSELCGWVEKCAKRLQEIGVAANTRIAMITCTTCQVIFVQLACSILQAVVVGINGYLPIGHAKYLFKFLHKEIKVIADVLCDFESFANDQNVTTTAKTNNKTGMMIFFSEGSTDPPKPTEISHQSIVINVQQLSCPVFSPPMQNQKFLLAISMLVKNTQVIINNDEMLTRFYILIQKINTFLVYGLTTASGFCTFSKFGNNNYKSVGVPLPGMVAKIVNIETNELCMPHQPGRLYVIGPQIQIRSHRSSKASNSLADVDGYLNTGDFAFYDRDGYIYIIGKIKNLIKYRGTLTPPSQVETFLLTHPGIEDCAVIGRQDALLGEVPAAFVVKTSKYSQLSPADVRQHVFGKIGHIKELRGGVFFVNEIPRSSSGKIIYRQLKQTWERDRSGLRETNSSSSLPNIGDGSTNKEKRGLRIAKLQKSASKPVIQINRVQIKGNTDHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNM3</accession>
    <name>A0A0N4UNM3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3192</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNM3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNM3"/>
    <dbReference type="WBParaSite" id="DME_0000950601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000950601-mRNA-1"/>
        <property type="gene ID" value="DME_0000950601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000950601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="858" mass="97417" checksum="244E2BE801AAC71D" modified="2015-12-09" version="1">MVGKEEQQSSAIRSKLSSDPSASALMLSIIRTLTNASSSDQKQSDCQRLEAGFKESSHSMDKLVQKHENDVGTCLDSFKKVSTRITKRIHSVRAGLMTCRSLLQCRRDDLKRLWTENAQQRHISNVLAQIEQLKKIENSVDETVAKGNYLLAANLLSEAGERTSNLLEIIKSLPENKVIESRECIAVLNAFSDSNRVDQKSFSLSNSNSDNISDHLSQNIQALCVFKNLYSTLSHFIQLMPTMLLRQIHITASVVCNAFSNSAKGDVENLTHYLNLILNQLKSSYIVHCALDDGLKKLTVEEAGNDENFILLSSKFWEMAQDAIEKVVVEYVQINSINPTISQKRSNTGEKFSLFKFDASACAASVRNRQSSKKMQLAICEPSPWNITVLYPLLEKFCCEREAESGEKPCKLRKFLHSFIIDVFIDRFKNKLELLAEQALQGRDAWRLVHYPSPKVLASCYNMFVVCEEIGKLIQTMENYTERLSALWLLVIDEFAKSTMSVYEKMLHSNDEEEKDRRKISAAWAVDEDISRLLKSLPNWFAVSHHEATPTPSATTPTVLLPANESESEIRQRNERESEILIGNLGTAKQLVRDELITDMELISSLACMHDSLKWFCTSMRTLISTLPDSCRRSMRKCIIQIQNSSKNSKTQQESIYAAVERRLAELDSTADTCLLIIHLELRVHCFFHLLPLARTRSSLPHDELDNEVIDLGRDLTHFHQALHSCLPPHKMKYLFDGLGHLSASIFIHSSQHMQKLTENGKKRVCRNIFAVQQRLSHLTGRRESELERARAFFELLNHDPDQLLALILERGAVFSHLEYTYLLALAIRSHPILSAQPGALEQRISQLKQILSQIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP32</accession>
    <name>A0A0N4UP32_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3322</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000123">
        <property type="protein sequence ID" value="VDN53349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP32"/>
    <dbReference type="STRING" id="318479.A0A0N4UP32"/>
    <dbReference type="WBParaSite" id="DME_0000970001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000970001-mRNA-1"/>
        <property type="gene ID" value="DME_0000970001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000101">
        <property type="entry name" value="N-alpha-acetyltransferase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000970001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21351" checksum="08E73219E98FAC77" modified="2015-12-09" version="1">MNIRVAKADDLLNTQHCNLLCLPENYQMKYYFYHALSWPQLSYVADDEKGNIVGYVLAKMEEETDDEPHGHITSLAVKRSYRRLGLAQKLMDQTARAMIETFNAKYVSLHVRVSNRAALNLYQNTLKFEISDVEPKYYADGEDAYAMKRSLIKFAVDNNITPADRKSFFSAKDDKEHSRRQKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP46</accession>
    <name>A0A0N4UP46_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANIS5_cation-bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000124">
        <property type="protein sequence ID" value="VDN53357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP46"/>
    <dbReference type="STRING" id="318479.A0A0N4UP46"/>
    <dbReference type="WBParaSite" id="DME_0000971401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000971401-mRNA-1"/>
        <property type="gene ID" value="DME_0000971401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000971401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32474" checksum="E6412490B8D60146" modified="2015-12-09" version="1">MIIGYDGSQNFAKKFVNLTKESKKELESILKKENLTKRELDDKLDAWAKKLGGSTLTTYNRVKNFTEEMERQFLEKIKESRLSDELKEKANQLHTVKTNKNLTLAQIKQKVEEIKKGLKKEDLKQIRNVMHELMRVMQQRKTRNAGCMSENALSNVDCKNAKQFMAIISNTTATKQQISDEILKWKSSQIPEKKIDVLMSDLEVLGDFVEKQMEQSSLSESAKKAIGELGTIFGDSNLTPIDEGRQINEIFSRLPSSVKEEITSFIAGLVNELIENHSFLPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPP4</accession>
    <name>A0A0N4UPP4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3492</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000140">
        <property type="protein sequence ID" value="VDN53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPP4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPP4"/>
    <dbReference type="WBParaSite" id="DME_0000994101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000994101-mRNA-1"/>
        <property type="gene ID" value="DME_0000994101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000994101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15724" checksum="77F5F145B5EA7A96" modified="2015-12-09" version="1">MRNQADMRESSNTSQCKYLSQLYVVPAVDAVEAGKGQLEISVNQGRVPNNVQMQGAGRCLVTFIPQYPGKYVIDVTFNGEQVQGCPIQVDILPKQVGKSVSTPIVSQQTTTIMPPGIYLIHLEQIYKIEKSLKRINFHIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ04</accession>
    <name>A0A0N4UQ04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3594</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000154">
        <property type="protein sequence ID" value="VDN53621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ04"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ04"/>
    <dbReference type="WBParaSite" id="DME_0001006701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001006701-mRNA-1"/>
        <property type="gene ID" value="DME_0001006701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="55"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001006701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49682" checksum="1877D07601FAC171" modified="2015-12-09" version="1">MALKGNQKQYHPKAYKNTYRIEAMRVLHTIALLLFSLHFDKLTAISCRDSKITEEMRSDVLKEHNSLRSQLANGKIKAAGEKFMPRSSNMQKLVERAQKWAENCDFNHSSRDFRNFSGENLYARWENKEPTLDKKQFRDAIEGWWWEELKNMRPQSKMRGASLGGVITHFTQMAWAITSRLGCGIAKCLNNNGYPYMVHVVCHYDPRGNWDDEIYEEGAPCSKCSQYLGKTCNEQGLCASSSRSAPAEEKTNRQKKQSMKKINEESEKTFVKFVDNKTPHEDTDEAPEEISFDELEELPRDYEENKESNEMPTSEEEAPAEEAYEQLHELPYEELEEIPTDYEDYEVPYEKKRPVEEPSEELEEQTSAEETPEPEPLQEVSFEELDEAPSEYEDNGKPEEQTPNEESTEQPEQAEEFEEIPIEYENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQL0</accession>
    <name>A0A0N4UQL0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3794</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000188">
        <property type="protein sequence ID" value="VDN53821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQL0"/>
    <dbReference type="WBParaSite" id="DME_0001030101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001030101-mRNA-1"/>
        <property type="gene ID" value="DME_0001030101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079341" evidence="2">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001030101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26190" checksum="A9E3A0D57B65C5A2" modified="2015-12-09" version="1">MLLYFCFFVFLVHGVKSGNDKAIENCNRDVGGQQRPTVDPSLCAHIDLPACAAIFPYHDAPGTIPTHRDPAMSYKIPENCTHASLKDFAQRSCPSLCAFCCKAKQFNCANDPFAGNHCEAFTLEMCRNASLNTIALMRCPMRCGLCDRPGAGGMCPNTFDDAVCTALAPVICLDEKAKNSCQKTCGLRTCLDNQNATAAQSNCRDDDQQCSENRRYCTIEPYATVMRGKCRLTCGHCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR16</accession>
    <name>A0A0N4UR16_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3938</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000225">
        <property type="protein sequence ID" value="VDN53965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR16"/>
    <dbReference type="WBParaSite" id="DME_0001048301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001048301-mRNA-1"/>
        <property type="gene ID" value="DME_0001048301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001048301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8751" checksum="486E858B97ADD28B" modified="2015-12-09" version="1">ESFRDSANDCRREEKVIVWHVLNVYASTFVRSEWPSFRFSPSDRSKNVTLHPVASLQRTQSLFSSLGNMTSFLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR52</accession>
    <name>A0A0N4UR52_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10924</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001277">
        <property type="protein sequence ID" value="VDN60951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR52"/>
    <dbReference type="WBParaSite" id="DME_0001052301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001052301-mRNA-1"/>
        <property type="gene ID" value="DME_0001052301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="294"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001052301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39340" checksum="25D64878F1021396" modified="2015-12-09" version="1">MKYTDDVSSELICVQECACISEQYEKKDGQCIEKNDTATRIEAELSVENLFKGTEKVTPTSTQRFVTKEFSAQITAQKTPAEVPTPKVCSGRICRLDEIITDTLCSLTDQKCGPNMVFRTIVGPLRMKVGISSYKMCIQQCTCDSNEYTKIGGQCIKEKSVPMRKETEFDGEILPKHCAGRVCALDEEIFNAPCSLTGKICGTNMIFNNISKLIENNGSEFCIQKCSCMGEEYVRANGQCILPARGNESATPTSTQRSASKHPQFPVQRTIEKTQSNCIGRSCKRIRDLLCTLTGRKCGDNMVYKTIKRLVYIDDSPEICIQQCKCVSKEYTEKGGRCIIRERSVKKSVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URE2</accession>
    <name>A0A0N4URE2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10937</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001282">
        <property type="protein sequence ID" value="VDN60964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URE2"/>
    <dbReference type="STRING" id="318479.A0A0N4URE2"/>
    <dbReference type="WBParaSite" id="DME_0001061801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001061801-mRNA-1"/>
        <property type="gene ID" value="DME_0001061801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="160"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001061801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39552" checksum="DEA4994F0973663A" modified="2015-12-09" version="1">MRHIQLWNCELEYKANKYIERCQFKLSRTVSREVVQNAYMYFYRKTEESLQTGFSFETSDDVYYHEIIGINDKEWKLATEIGCSMKLCSKPGESLRLFLCLYKLRSSKPAKSTFKSLPQISTSSKLPASEDLAVSSPMDILKINSMENEGDCQGSKIVAVTKQKIINRFNWLRKLIIFAIMQATGSTFHYASDFSFRWNCFLEELSTQSAKNCSLGPSKDALESGFDESRQVYWDNSGKILNESLILDAITTWWKSGSADNYIEDLESLDSEAFVENRVFFIQLANKETTYFGCGLADCQADGRNMQMVVCHYPRIETKKLTELWRTLNLHVDKIGEIIREHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH9</accession>
    <name>A0A0N4URH9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001289">
        <property type="protein sequence ID" value="VDN60972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH9"/>
    <dbReference type="WBParaSite" id="DME_0001066001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001066001-mRNA-1"/>
        <property type="gene ID" value="DME_0001066001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079755" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001066001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8233" checksum="EF34935705356B6E" modified="2015-12-09" version="1">MLVSLFILASLCNIVNADNVLVINVCSIPVPNGQNFVQRPSVPVDNCQDRDPPACFEIFKLENADIAVYAQNLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q311</accession>
    <name>A0A158Q311_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5772</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A158Q311"/>
    <dbReference type="STRING" id="318479.A0A158Q311"/>
    <dbReference type="WBParaSite" id="DME_0000141201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000141201-mRNA-1"/>
        <property type="gene ID" value="DME_0000141201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="168"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
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    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
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            <position position="354"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
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            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000141201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49677" checksum="883A4791F5BC544D" modified="2016-06-08" version="1">MIGGLFVYNHKGEVLISRIYRDDVSRNAVDAFRVNVIHARQQVRTPVTIMARTSFFHIKRGNVWICAVTRQNINAAMVFEFLNRFADTMQSYFGKLNEENVKNNFVLIYELLDEILDFGYPQNTDPGVLKTFITQQGVRTASKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVIEYVNLLMSQQGQVLSAHVAGKVAMKSYLSGMPECKFGINDKLTIEGKGRSGSDDPSKTTRTSVAIDDCQFHQCVKLTKFDTEHAISFIPPDGEYELMRYRTTKDIQLPFRVIPLVRETSRNKMEVKVVVKSNFKPSLLAQKIEVRIPTPPNTSGVQLICMKGKAKYKAGENAIVWKIKRMSGMKESQISAEIDLLSTGAAEKKKWNRPPVSMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGLYETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q338</accession>
    <name>A0A158Q338_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DME_LOCUS5900</name>
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    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q338"/>
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        <property type="gene ID" value="DME_0000154001"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000154001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61347" checksum="C009A1D4874C24DF" modified="2016-06-08" version="1">MERYRKGKEANETVYDTSHQFLSSNREYSNLTSPKQIHSASDTKVFGQVSQRLEPEYKNKYTKQEQRKSRSKAFGGSGFKNKLNSGLSHRSKSVGLESGIKRSTSSRQENWDRAKRIIGGSRRSFNDLKTENSKLTMSLDRIAMAASGSPRFKSSHGSLFVGDGGMSTFEKMSRMDLVLNIDSSHQEIQPSTSMNSLSPMPGLVKIPPKKFGFNRTKQLLAQNLQKSITGSYSKYDGERATHHYNPEDPMNMPAMVDCLESAVKKGRERLLEADRRNSDFVEELSFRGHSNRYPKRNLNSFPSGCSKSMGVTHNLASQVIHERTGSREETDVLNQDSSTSSSTDITESKMKKKLVVNSDLPKTQSTEPSLATSAPPIPPKTYLLKKTAPSDQLSIQVNNTTDRSHASSSVSKTQITPSSSPTKKNQNHNNLPELSKLTGNYCDLIQSIDSTCVSRKPSETNRTLYVSIDSVATVAASKAQATMMEVRERQYQVNGLQTNGKYYSELSLNGRKKTRRSLDQPRQKDSFVRRFWRRPTFSLSYTDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q355</accession>
    <name>A0A158Q355_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6035</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q355"/>
    <dbReference type="STRING" id="318479.A0A158Q355"/>
    <dbReference type="WBParaSite" id="DME_0000167501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000167501-mRNA-1"/>
        <property type="gene ID" value="DME_0000167501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="44"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000167501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31086" checksum="C2C7D6695DA6C619" modified="2016-06-08" version="1">MIKKSFQHGFAEKWLKDIKKIVWISVQITFSLVYGALLLVGLIGNGGVLLAVSTNRRLRSARNIFLLNLILTDILLCVTAIPVTPWYALTKDWQFGPLMCRLMPLSNSCSVFVTSWSLTVIALDKFIHIMDPTRAPISIKRAVLITLIIWLVCSLINVPYLMSYELVDGAYYVPKNATPFCGQFCDEINWQGETPRRLYGSAVVLLQFVVPLAVITYCYSRILAKVAKDMIIQNAQFSKSLTSTQRIDAVNRKKKVVAFFVKCTCFSLAKISGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4H6</accession>
    <name>A0A158Q4H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rap guanine nucleotide exchange factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8739</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4H6"/>
    <dbReference type="STRING" id="318479.A0A158Q4H6"/>
    <dbReference type="WBParaSite" id="DME_0000485601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000485601-mRNA-1"/>
        <property type="gene ID" value="DME_0000485601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="350"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="481"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="600"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="834"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="957"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000485601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="158248" checksum="A5D3C08ED15FFD5B" modified="2016-06-08" version="1">MDNYNRSFFEAISKTPSSRTNQDLRTIYCNLRRLDIFHNLNDDPLKAICRTARYEQFPSNFILFRRGQVATCWYILLSGSVFIDSQIYLPYECFGKRNGLNYRRISDCVLLQQSEMIVIDYPDVKHILVNQEQNNSTLRNNDDTVSSRKAVHSLNLNPVQSSTSSVESALLYNSNNNNNNHSSDLPPAPLPPQRMRKNNTSRMPHTSVLPSSSLTVFINRSNNNSIMHEMHDSDADRGYKSQIYLNGLSTTDEPILTVKHRTYKSNSLGGSNISRGRLSSTASSSTNDDDLHGLPETAVDSEEEDDESCPSHDSYHELKDSVRECLEKEPSERNSDDLCILLDFMQHMSALASLPLSIKKQLCLKMVFAVVAEAGTVVMHHNERLDAWSVIVNGQVEVIYPTGERYEYKLGDSFGAKPIFTPQYHVGEMRTLVDDCEFVLVEHHDYCSIMSTIGEHIERQSDLLTGEIVSETERRAFGTQIGQILIKANKDKLIEHLIEERDSVMDAYYVEDFLLMYRVFITDPTMIFEKLMHWFAEIILRDKVARIVLLWVNNHYNDFECNSEMLELLDRFEQALERDQMFSQQSLLNIACSVKSRARTLTYTRSNRDQPLTFSIIGGKENGSSGIFISNVQESSYADKIGLKRGDQIIEVNGQTFKGINLSRALEILHSNTHISLVVKSNSLGFKEIITLSERAIDVIDASDTKSVLIAGRITKNKLFQSNHASMANMVGIIHEDDSRHNSSSHSSRSRNIIAGIMTKSSVMDKIVTMLKSLPNNNSIDNLLDDDRNVESVRMNALRTSRSNPDIANHSIVSGNMIDTGIAHYYQPMHSTCPEHVLKIYRADQSFKYLTVYKETTAQNVVQLALQEFGMNSDAGSLEWSLCETTVTSGGVIKQRRLPDQLSNLAERIQLNSRYYLKNNSRRRKRYSFYFRSDPLVPDELAPEILKEAEVQLLQLNAQILAAQLTLQDFAVFSSIEPTEYVDNLFNLETRYGWPKLTEFEQLFNKEMWWVATEICRERNLQRRAKLVKKFIKVARYCRDFRNFNSMFAIMSGLSKPPVRRLHLTWERVPTKYVKTFEDIQHLVDPSRNMSKYRQLISLVSQEPPIIPIYPVLKKDLTFSHEGNPTYCEKLVNFEKLRMIAKAVRCVTKLCSAPYEIGAMARQSGGNVSDALLHMNSFDNGNIKVATMRKISSSTVKGSMQPRKKMYEQALMVRKVKSYLSNIGVIDCETELDRLSLECEAGNNSSNINRRRVPSPSPSSLSSVSSTSDQRKFAAPKFGVESPQAVQKMLSLVQNSRMKQQNVILGSALTQITASPVQSPIIPSKGARMRSAPVSLKRIPSLNLSRPVSNIVSDIQPVDLTAESSSVTNLYSSVISNSGKIFYLLIFHMKFHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4K5</accession>
    <name>A0A158Q4K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPM_phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8892</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4K5"/>
    <dbReference type="STRING" id="318479.A0A158Q4K5"/>
    <dbReference type="WBParaSite" id="DME_0000509301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000509301-mRNA-1"/>
        <property type="gene ID" value="DME_0000509301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813772at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF6">
        <property type="entry name" value="TPM_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041046060" evidence="3">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000509301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="41329" checksum="1A700C5803E8AB44" modified="2016-06-08" version="1">MTRKKFKRLFILLLFLQQSFCQRVEWDASNFPNPTAGDFKRCNMKTTANICDPDQVLSEQERYRLNHELHQLESRTRQGHAPDFCQKKGITAAMAIAKHVRGGSQEAVKEMANQMLRKWSLDNQCQKSVVIVVATEDKRFWVARAPRVPVYAAEFTQIFIDQKNLFEQGQYQQALANIVQQTWERALSKQGPGAPEGPGPVDGDFGKGGIPEKPRYGPDGPGSKMMKLPSIPFWIWLVLILVVIPILCCCCCLCYCCFCRGKGSSGTSRRQRPSDIGGGGGIESGGRPGRSGIGGGGLNNFLGGLGGAGIGSIAGRMLSGGSRGGGLGGLFGGHGSRGGGAMDMSGYQGGGAYPSAPSYPTGPKSGGRGLYPSAVVEDEGGGGSWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Q2</accession>
    <name>A0A158Q4Q2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CheR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9158</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Q2"/>
    <dbReference type="STRING" id="318479.A0A158Q4Q2"/>
    <dbReference type="WBParaSite" id="DME_0000535901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000535901-mRNA-1"/>
        <property type="gene ID" value="DME_0000535901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15794at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF1">
        <property type="entry name" value="RIKEN CDNA 2700097O09 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000535901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40439" checksum="3D5C1AA43CF0CED7" modified="2016-06-08" version="1">MLNIADAEKEFNKLLDRIEPRIIPQFFTWINESFCVLNDFDGKKVNFSTTGLQNERLTEADAILYKISLDIRHEVPLNAVLESENIYWPQIGLDSDCDPKTTVRFIAVHVDSFLYDDDAVDDLVDQGKLSRNYCVRCGSLDVKPLIFFSHSLSLLQLRYIFTTLVPLNANMSGKLILDIGSRLGCVLYASYLYRISIFFIPVEIRNKKCVLLDSDFSEGKVNTVGVEVNKEFCALQNKIIGENNMAHSIKVINDDIRNQGHLVASADVVVLNNVFSFFLPPEEQINCWNFLHRAVRRGAVIVSIPSMEILTEHLQLEFSISDWLDKIDSGHLAARFAGTNEDLFDDCVKITLYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q502</accession>
    <name>A0A158Q502_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CUGBP Elav-like family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9449</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q502"/>
    <dbReference type="STRING" id="318479.A0A158Q502"/>
    <dbReference type="WBParaSite" id="DME_0000615301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000615301-mRNA-1"/>
        <property type="gene ID" value="DME_0000615301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000322">
        <property type="entry name" value="CUGBP Elav-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="128"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="425"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000615301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56154" checksum="251BCBF77EE7EA72" modified="2016-06-08" version="1">MNNNISSVISSNSGAATSVNGHLNRSTQNSTTDDKPDVDTIKLFAGQIPRSWNEDDCRKFFEKYGRVFTINILRDKATQVSRGCCFVKYYRRADATRAVNELHDIVTLPSMHHPIQIKPADAENRNERKLFVGMISKQMNEENIRSMFESFGTIEDCSVLKDVEGKSRGCAFVTFTQRSYAQAAIKQMHASQTMEGCSKPIVVKFADTQREKEAKKRKTPPSNSLPNSSTTLNQGELQQALINLATYGLFSLQPQPALLNILAALNSSSVDLLANQNQTNFAFSDSSSDSNIQVSPSVLTGIAPAITPTNDLRNTIHSNNLIPLINNPSNGFDVLQTTYPSFSYANTHFQNLPTSSLFTGNSNPVQLLNGNGSTSHVLNNNNAAQFLGSNNVAVQLLGVNNNAVQFLNVNNNTGVASSTPGPEGCNLFVYHLPPDYDESDLVRLFSPHGKIISTKVFRNPATNLSKCFGFVSYDNIKSARNAIGALNGLVVSSNKRLKVQYKRNDKQYAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Q7</accession>
    <name>A0A158Q5Q7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS2104</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Q7"/>
    <dbReference type="STRING" id="318479.A0A158Q5Q7"/>
    <dbReference type="WBParaSite" id="DME_0000797901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000797901-mRNA-1"/>
        <property type="gene ID" value="DME_0000797901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021700">
        <property type="term" value="P:developmental maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051222">
        <property type="term" value="P:positive regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000004">
        <property type="entry name" value="Kinesin-like protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000204">
        <property type="entry name" value="kinesin-like protein unc-104 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="3"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="1552"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1456"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="601"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1474"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN52131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000797901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1665" mass="190651" checksum="41CBE16F206DB43C" modified="2016-06-08" version="1">MSSVKVAVRVRPFNARELSNDSKMVIAMTDNTTTIIGGIGAERSHSFNFDYSYWSFNKDDTHYASQQKVYDDLGVEMLDHSFEGYNVCIFAYGQTGSGKSYTMMGKPNDEKEMGIIPRLCNHLFQRIHDNEDPNLQYSVEVSYMEIYCERVRDLLNPSNGGNLRVREHPLLGPYVDDLTKLAVCSYQDIYDLMDEGNKARTVAATNMNSTSSRSHAVFTIVLTQNRHDVSTNLTCEKVSKISLVDLAGSERATSTGAEGQRLKEGANINKSLTTLGLVISKLAEDANKRKGKGKSVIPYRDSVLTWLLRENLGGNSKTAMIAALSPADINFDETLSTLRYADRAKQIVCQAKVNEDPNAKLIRELKEEVNKLRALLETKGIDSEDPMTTKALYSARDHDTIEQLKASEKLIAELNQTWEEKLRKTEEIRRQREDELREMGLATGEDGSTLGVFSPKKLPHLVNLNEDPLMSECLLYYLKEGVTRVGRPEAKNRPDILLSGQLILDEHCRFLNDEGIVYLEPENNAQCFVNGKPVKQATILHTGSRVILGKYHVFRYNDPQEARQSRQNLSTLTSEYSNSSEPLDWKYAQQELLEKQGIDLKAEMEKKMIEMESQYRKEREELELKMIRQTKEYEMRIETLQRQVDLAQSMISSTCSTWDGERLLSSSLLCFEPECKWTADEERIARRTVMKWRYHQFTSVRDDLWGNAIFLKEANAISIELKKKVQFQFTLVTDTMYSPMPPDLLLPGEDLALRPYPKTVVAVQVQDLKNGATHYWSIEKLKNQLASLTHGSSYRMRLEDMRRYYNSDFSEAFTPESPSSCMQQSWLNAMQFNPAFLIPDRQRLEIMREMYQTEGELSPGSPEDPMMDALLGTDPFYDRFPWFRMIGRAFVYLSNLIHNVPLVHKVVIVNERAEVKGHLRVAIEPILHEDMQKQQEKGVQKFVKCDFREEDFIKYAKQSKVNQNSERAVGGKKIKGALDLPNFNEQTNHIWNNYPDHMKQNSEYCFKITVLEAIDISDQYADIFCQFNFLHRHDEAFSTEPMKNSSKCPLVFNHIQNIRVAMTPTFLHYVNHFPIIFEVFGHYRVTSQQFIFERQNSALGRRLSTKLSFQQPSLVISTPVKSKKANIIPNNLNQIHSKYDLLVWFEICELAGNGEYVPAIVDHAQGLPTHGIFLLHQGIQRRLKMTICHEKGDDVKWRDCQELVVGRIRTNPEWNGEDIDVLSLGLFPGTFLEFSMDDRVFFQFEAAWDSSLHNSPLLNKVSNYGEVVYMTLSAYMELENCAQPAVITKDLSMMIYARDSKISAASRFCRSLIGGISKSPEMNRVPGVYELSFKEALDTGSPGAVRRQRRVLDTSSAYVRGEENLGLWRPRGDSLIFEHQFELDKLSRIQQVERVRLFLRLRAKLKFAKKKNNDSNDLPTPVSPCTPKRLIPSEVKFTQKEMNIVRKVIKLIKQRVPMNKDPPTGKIMEQSDHSSSSLTESLTSPSSEKNDLTKPSFEILAKMKSRSNTSLTLSPEGCCDTDSGIKRSMSGSRISNMSLLIPEVTEERVGFVVSKKGYMNFLEEKTQGWVKRWVVVRRPYILLFRDDRDLVIRGVINLANARVEYSEDQQAMLKVPNTFSVCTNHRGFLMQITDGQMYDWLYAINPLLAGEMRSKMGSNAMVPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q615</accession>
    <name>A0A158Q615_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2693</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q615"/>
    <dbReference type="STRING" id="318479.A0A158Q615"/>
    <dbReference type="WBParaSite" id="DME_0000881701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000881701-mRNA-1"/>
        <property type="gene ID" value="DME_0000881701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067827at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF15">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000881701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12773" checksum="DC26D18CEC7FC401" modified="2016-06-08" version="1">MLSGRDRGRQQDINEAFNQLREIIPCYPVNRKMSKQEILRGAIRYMKILEYLLECRHRWLGHVFRRKSQELTYISLLAKPCDAMALDRAAWRCITLVASGASLASKDKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q679</accession>
    <name>A0A158Q679_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3027</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000097">
        <property type="protein sequence ID" value="VDN53054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q679"/>
    <dbReference type="STRING" id="318479.A0A158Q679"/>
    <dbReference type="WBParaSite" id="DME_0000930501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000930501-mRNA-1"/>
        <property type="gene ID" value="DME_0000930501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860166at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="221"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000930501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="36680" checksum="52FE0110735386CC" modified="2016-06-08" version="1">MPTRIRIALPLIAFTTVLGSIKNPIAALRTLSVSSSACHSAIDHFLKEVMCMSSCHYVIISPKSMLALLLLCISADFSLQQQPPPPPPLPPPPGPLPPPPQPQPQPQPQQQPPQPQQQPHPPPALPQLPAVQQRPDYENLLRDTIADCLSDYQCRVFEHCVVGKCIRDTRACPGGTCPAGMVCVAGRCLPDPLIATTESILGRLKEECPSPWTFSQQFNACYYVGRGSYNFFTASAECRRLGGTVASIGSSGEMTYVNGLVGSGAYWIGYHHTRFSSNWEDGSPVGFTNYRRGQPDGCCGGAGCTLVNYRSNLGEWDDAGCHIIWRTPTYAVCKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6E6</accession>
    <name>A0A158Q6E6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10783</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001247">
        <property type="protein sequence ID" value="VDN60810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6E6"/>
    <dbReference type="STRING" id="318479.A0A158Q6E6"/>
    <dbReference type="WBParaSite" id="DME_0000987201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000987201-mRNA-1"/>
        <property type="gene ID" value="DME_0000987201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="206"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000987201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="34445" checksum="D4A37FF5F14676FB" modified="2016-06-08" version="1">MGVTRRIPLLSDEKIYDYGEFVLYDNDSGNENNENQEESGEREPYSKCFSRDLLVKDLLNKRNCGNRKLRRRENELALFSYADDEIYFDCSDLLPNNETSFDLLLNDETKMKIWIDFIEKNEEEQNEFLFGIEHSYKRSASNDKNDNENGTRNPLYSADACFARLPIRFKKLFRKRNIPKVFFFHNYRLRQIDLYEAKEEKIMKEKNLINENEEKLRSFFLSVKDKSEEWISPVIPCSFQRLILHGVSRYLLLNSYGVGIHPERIIKVRNLKPYFVPPHDTLVDYICKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PAR4</accession>
    <name>A0A3P7PAR4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc transporter ZIP14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PAR4"/>
    <dbReference type="STRING" id="318479.A0A3P7PAR4"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46691" checksum="E5539A9EE281F800" modified="2019-02-13" version="1">MEVPSMALKNFEALQSLSADLDRSLNVTDLRFIELCTHWWKSLTKNLVWCFGLVCVTLISLCAAVGILFIRGLSKKSYNRFITIFAAVGVGSLISSSTLHLVPQGLEIVDGKNFDFITIQMFVIVGIYTFFFCDKFLKISLESKKVTRHFFINICFLCHSSNDKLSQLKKFQLIDAGISESGPTEVNPGVISLRSSDTLVPLDNTIHQYRDRTESLKSRNGIEIMENIDMSRQAHGICVHDHEIVFNHKKDSAIKTVAWMIIFGDGLHNFIDGVSIGAAFNESLISGFSVSVAVFAEEFPHELGDVAILLSAGMSLKQTLFYNLLSTVTCFIGFVIGVMLGSIETFLRYVFGFSGGMFLYIALSCMMPEMKQTMEEALRIGHQEALSVLLLQTLGLTGGTLSMFFFARYGHLIEITGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PM47</accession>
    <name>A0A3P7PM47_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PM47"/>
    <dbReference type="STRING" id="318479.A0A3P7PM47"/>
    <dbReference type="OrthoDB" id="5861642at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="109" mass="12064" checksum="41991CB1513F104D" modified="2019-02-13" version="1">MTGGTTKITQKQICAGSFLHGTAPGDSGGPLQIMGPDGRYYQIGITSFGADLLEGVIDQEKYPGIYTRVALYYNWIHSMMESNGTNLIIAPNFYIYIFIFCILLIMNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PSI3</accession>
    <name>A0A3P7PSI3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PSI3"/>
    <dbReference type="STRING" id="318479.A0A3P7PSI3"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="302" mass="33775" checksum="9F99C99947CA5577" modified="2019-02-13" version="1">MAVSSWDCTVRIYHIPAGPITATERRVYTHSKAVLACCFFNRSEVASGGLDNIVKTFNLEVGSECVLGRHEAPVRCIEYCKDQSLLASGGWDSIVKLWDVRTKTTTGFGNNGGKVYAMDAIANRVIVGTSERKIVVWDVRNLEQPEQIRDSPLKFQTRAIKCFPNGDAFVVSSIEGRVAVEYFDQSPEVQKNKYAFKCHREKTESGEEFIYPVNCIAFHPIYSTFVTGGSDALVSIWDPFNRKRICQLHKFPTTIVSVSFNSSGSQLAIATSYMDELKERPNPEPESSVVVRKITDVEARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PU43</accession>
    <name>A0A3P7PU43_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PU43"/>
    <dbReference type="STRING" id="318479.A0A3P7PU43"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF250">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="2">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="215" mass="24836" checksum="B450042174B2C83B" modified="2019-02-13" version="1">MQYFYQINVRIAVVDIFQTRRNDLSLYSFEDYRNKRLSMLPHHDFAALISYRYAGGLAFVGGMCTSKAVMLCGFYPHNPAAMGGIFFHEVAHLVGVPHNNASEKLEISNCQCNHLRHRWKIIGSTDCLKIPGFDHDCTLQQMVNLLSKNHCIKKYEKIPFLTPITIEQSLPICGNGIVERYEQCDCGLRNYCYDLNCRADLCIQIIRTWQMVMHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0Q8</accession>
    <name>A0A3P7Q0Q8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0Q8"/>
    <dbReference type="STRING" id="318479.A0A3P7Q0Q8"/>
    <dbReference type="OrthoDB" id="5875717at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="82" mass="9363" checksum="51312BAD94399E80" modified="2019-02-13" version="1">MNECLDSRLKQHGFLSDQVKFFIENSNTPLPENCDANFLAGQKIVVRSKNFLFSLFLISCFELSSKVHSPIEFSMNDLVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q1J9</accession>
    <name>A0A3P7Q1J9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q1J9"/>
    <dbReference type="STRING" id="318479.A0A3P7Q1J9"/>
    <dbReference type="OrthoDB" id="5832686at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="174" mass="20734" checksum="70357EC311679948" modified="2019-02-13" version="1">MKKKLEKFERDKQQWENQKRVLESKQPMDVQILQSQKRELTMQLDREQAEKQELFLQINTLIAQLAEISRDKMEQSSASLEAENEVLKNEFRNVQEIQTRLNNDVQNLQEELRLKNTEVEITRDEVKRLQILLDSERMRFEETVDGLERDLQLKAAALQNAMLAKKVCIEIFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q4B6</accession>
    <name>A0A3P7Q4B6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q4B6"/>
    <dbReference type="STRING" id="318479.A0A3P7Q4B6"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="349" mass="40354" checksum="66B9B46B137906AC" modified="2019-02-13" version="1">MMTNIFGDASDDDDGDDDEKVLSTKDKVNFNLLQFAYTYVFMLLKYGLGPERCLLRKEWDFDIMLREKKAERRRPRRRRHDGSIDVGGIYDDKIKSLMDAMKVAAKTDRSCNIARKPAVQKRILLPQVKALLIKYDLMEYIIDNGMLNIVAEWLAPLPDKSLPALEIRTTLLKILQEYNRLDQGILKQSGLGKAVMLLYKHPKETKENKILAAKLISEWARPIFHLETDFRSMTKEERIQRDYAQLSAAKRKSIKKIKKIRSLSNEADKNNEPRVGEKGFIMRARVPRVLGKDYVVRPKNNVEGQFRGATKSRANERLDRAQREFNARTKQNKFRRAIGVSIGGRNIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QAE7</accession>
    <name>A0A3P7QAE7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001268">
        <property type="protein sequence ID" value="VDN60923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QAE7"/>
    <dbReference type="STRING" id="318479.A0A3P7QAE7"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000457">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="497"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="560" mass="64365" checksum="9DD3400A8D2729FA" modified="2019-02-13" version="1">MIHHCFFVSRDWCISRQLWWGHRIPSYFVTVDDEKIPPGNADDNNYWISAHTETEAIEKAAKRFGVPREKISLKWDEDVLDTWFSSGIWPFSIFGWPDQTSDLKQFFPSSVLETGHDILFFWVARMVFLSQELTGQLPFKEVFLHAVIRDAHGRKMSKSLGNVVDPIDVIHGISLDDLNKKLEFGNLDERYELEKAREGQSRDYPHGIPECGTDAVRFALISYTSQSRDINLDVLRVQGYRFFCNKIWQAVRFTLMQLDIDFKPLDPFQLLKCSSLLDKWILSRLSATIEACQSGLSSYNFHVAANALYRFWLYDFCDIFIEGSKPILLQSESGSSLAVQFVLYECVDTALRLLAPFMPFITEELWQRFVRKPSNMNVPSICVAEYPQVSQYPYRNEELELRILKAMEIVKTVRSLRSDYGLTPKIKTDLYIFYELDSVDISDLSSFIGTLASSNKVIILEAEGVSQIPNGCAQVTVSAKCKIALALEGIIDMGKELNKLYIKRNKLLEQLRKLEEQTTMVDYLDRVPLNIRVNNAEKVDAYKSEIAHLNEAINALENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QMP6</accession>
    <name>A0A3P7QMP6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QMP6"/>
    <dbReference type="STRING" id="318479.A0A3P7QMP6"/>
    <dbReference type="OrthoDB" id="6516566at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09566">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037618">
        <property type="entry name" value="LIPB1/2_SAM_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF14">
        <property type="entry name" value="AT31531P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="655"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="858" mass="96600" checksum="5F51C9EA7276FC0C" modified="2019-02-13" version="1">MLLEALPFIIESLSKSPSPSMSTVSCPEYPELQEKLHRLALARDSLSLQVTVLTEQVGAQKEKIRDLEHLLASKRNKLDSTEELLQEHAFNRGDLESKKLDLMAEVSNLKLKYATLEREKFETERKLRLSQAEIEHLNQSMQGFMMQHGLHPQFQNIQIQAQGTLPQTILNESIIKRTGEPASEMEQLRLAVQRLIVDNEQKLENFQDMHINSLRNALDEYCRYERENHYNSPSLSVQRTGIINGTKKQSQQQQQLGVQPFDINVQIRKLLMEDYNDHIAHSSSFPSNFYSTQQHQNTSTSSRTPSAIQSSSSYTSSLSAASPQHSWSNSGTPRHHVQYGNIALNTTGLSQATSNSPGTSVSNYRSPSSPAARQLAAELDELRRIGGEIQQKHDISMNNGSLSRSLKSAKAASTLTLPRKKLSSTASTGISGEFPIIVSRSAASVSGASRRPMRSYRQQMNKWLHDKILSRVDKRSTSAPNLGPRAIDALCSDVDDYDDDDGHGRRTTASENENEIESDDEVMRGRQSRFATDRFKRDRTRTSLKNLLGKLTRSTSQEIRSSEIRRGSATRSSVSARLASVGPVAGAIALRPPIQQFVDWTTDQICEWIAEIGFSLYVPEVGRFELLMKNVLHRKRLRCILNSINRGISDSSDRMDVHQVVRWLDDIGIPQYGDNFAENMIDGQMLTILTAQDLMEMKITSALHHATIARGIQFLRSIDFCPNRIERHFNPWLKAIDLAEFTPNLLCAGIHGALMVHEPTFTAESLAEVLQIPPHKTLLRRHLATHFNQLLGQDIISHKRTILAQPYVAQLAPSLKIRLVKKGFSLTRKKGKSEVYVEPDELVCPPSNSRIKYSQNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SJK3</accession>
    <name>A0A3P7SJK3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SJK3"/>
    <dbReference type="OrthoDB" id="6432511at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="326" mass="37465" checksum="0B57209C40761C00" modified="2019-02-13" version="1">MKNCSDRKYCNFIDTPTVTCGPEKISIEGRSEDLFEGVIFVKNWRRINGCSVNYTLGDNSTNPKFSIALNKIAQCGLELRRNADSKDLEIFAIFVFSFHPNFVTAGDRSFAVQCIFLQQQITVATKFNFISYVKYKLFKFPYFHRRSIIRTMNFSDISTKGIIGATAEMPSTQLTIVEGRIPDQTLQPAHTVMVGQQLMYIWHMPTSSEIYGFRVKECFAEAKDGRKTIIIEDSCSIDPLIVSHVKYSESLDKAFADGLAFKFPDADDLWITCMLQICLRKFEHLTIHSNNLLFCTIQPVKFFYIFFTLMASNDNLFFKISFCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SKZ1</accession>
    <name>A0A3P7SKZ1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SKZ1"/>
    <dbReference type="STRING" id="318479.A0A3P7SKZ1"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF12">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="194" mass="21859" checksum="D0B7F79C41AC7E5D" modified="2019-02-13" version="1">MLPNYCILDMIFVMDFSGGTLDKHNAYINISSAIIESLSLSRSTIQVGMVRYSGPGRADTVFHLNKHNSTKEAILDMKRADHMGGVTYTGQAIQYSIKEFNEEYGGRKQSKKIIIIFTDGYSQDPSLAAENATKLGIEIHAVAIDDELIKSHQKLQSQKFRIILFFLGRSILIIHLYPTLHNYSMNTCLFSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SYP1</accession>
    <name>A0A3P7SYP1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SYP1"/>
    <dbReference type="OrthoDB" id="5866012at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="265" mass="31261" checksum="1F1647A04929AF09" modified="2019-02-13" version="1">MLHNVTIMDEENLQISSKNSHRSFKLLVRDEIFLIDAEWLSKLSPIFAKILEEKDFENGELLREIVDESSADIADFLQCLKNFCNINNENFKTIIRLAKKYQIECLINACENYIRNQCDINMKANEALSMLIIAFEEHLKKDTIKKLIERIAHEDKTNLQRMKIGRVLNPQVYFSFFHFFANLNVTKINEIKTMNKHLLKQVRNKIQYKRAQCDFCKKITDSAFCEGCKLHLCHSHWTNNECVSDYANQILNDLKSNLVEFEWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T2M9</accession>
    <name>A0A3P7T2M9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001213">
        <property type="protein sequence ID" value="VDN60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T2M9"/>
    <dbReference type="STRING" id="318479.A0A3P7T2M9"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="180" mass="21038" checksum="C14301BB8A8AA318" modified="2019-02-13" version="1">MPIFHRNYKNYRNLLIKSEPPNGYIKHWITKEHNKFRRIVPASDMQMLYWSNELARSAQRHANRCDFRHSRDRVNVGENIWAAPYSNYSNAIRLWFDEVYDKKCDCKHAYKHCCGHYVQVVWAETNLVGCGYAHCHDILGVLGHGHRHIFVCHYNPQGNTVLVTNAPACFDGLCYAPNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U318</accession>
    <name>A0A0N4U318_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5464</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U318"/>
    <dbReference type="STRING" id="318479.A0A0N4U318"/>
    <dbReference type="WBParaSite" id="DME_0000110401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000110401-mRNA-1"/>
        <property type="gene ID" value="DME_0000110401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000110401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35724" checksum="1843657E08523C98" modified="2015-12-09" version="1">MLPLKLFDFRLNLMVQKAMSDSPDTTPDFHVSRKIKKPLMEKMRRTRINKCLDRLKDILLEITPRQGTKLEKADILEWTVEFVRRAHQAKILGIVDRDLVPLCSKWYSEGFSMATAVCGHYLETRNGLFPTAFLAHQFKVELLQYLQSQQQSIISSCLTNQSTEQVPCTNQLQSQPSVLLYNRFPMAPVKLHQYSGQMLPPDPQTFMVQQCHLSCEPTIMEHSLNVGTKKEKEIKAIKDGTSSVVSKGNISEVGKISSVSESEQTNLTSSKRFVNPNSSVSKHNLLDLTPENSKIFNKNIGIDIPKQCSLWRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3E5</accession>
    <name>A0A0N4U3E5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5608</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3E5"/>
    <dbReference type="STRING" id="318479.A0A0N4U3E5"/>
    <dbReference type="WBParaSite" id="DME_0000124801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000124801-mRNA-1"/>
        <property type="gene ID" value="DME_0000124801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000124801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30277" checksum="7522AD58D3CF32D4" modified="2015-12-09" version="1">TFFSHALKDFLVNCSWVAQVEQRNYCGSQLVARWSATGSIFTQLLIFFIFFVSIFKLIFSLNFYLHESHRFSYFMAIAASTIPVPGGIFMPSFVLGAGIGRLFGEITSHIFPDGIRNDGRLLVHPGVYSIVGATAFCGAITHTISVSVIAFELTGQLLHILPVMLAVMISNTICSSLQPSFFDSIIRIKRLPYLPDIPKSTPEVHEIRVDQIMIKEVISLSAKTTYLELQQYLAIRPRIHALPLVDSPGFLEIPLFFFLKRDFDESDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3N8</accession>
    <name>A0A0N4U3N8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5708</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3N8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3N8"/>
    <dbReference type="WBParaSite" id="DME_0000134801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000134801-mRNA-1"/>
        <property type="gene ID" value="DME_0000134801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845308at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000134801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13442" checksum="071B8396633527F4" modified="2015-12-09" version="1">MQSSVVHRLDLCQAKIQNFWLSDFVNARCSDLVLYPVSAVDQSDQYRFDYSDVSFGNTHSQGASVTITCTTGGQPATVEGYDQQRSSITSGPNLLAVCSNVGGSQYTWTILGRILQFVDCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3Q5</accession>
    <name>A0A0N4U3Q5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5725</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3Q5"/>
    <dbReference type="STRING" id="318479.A0A0N4U3Q5"/>
    <dbReference type="WBParaSite" id="DME_0000136501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000136501-mRNA-1"/>
        <property type="gene ID" value="DME_0000136501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03156">
        <property type="entry name" value="uroplakin_I_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000136501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28408" checksum="A0A0F36555FDC7B5" modified="2015-12-09" version="1">MSGFSRWSAYGTFGRSLKTLFFTLQFLSVLFLHLVLVDGIWLVQTRSQYADLLEPSLYVDVARIMIVISIFALINALLSVYAVTKELRCMIYSYAIASFVIFLMLFIGGIMGFVFEHQLSHKIPLHLKMLTSLRELYGMPEMQGVTHAWDELQTNFQCCGVNGSDNLHVWRTSKWYMRQKEPKQLLPLSCCIRGMEAFCLKMSLSHETDAYENFAHVKTCYMHLRSDLLRVMNIAAWLVVVCASLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3U0</accession>
    <name>A0A0N4U3U0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5763</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3U0"/>
    <dbReference type="STRING" id="318479.A0A0N4U3U0"/>
    <dbReference type="WBParaSite" id="DME_0000140301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140301-mRNA-1"/>
        <property type="gene ID" value="DME_0000140301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF34">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="56"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="42354" checksum="2EC733C6F2941C47" modified="2016-06-08" version="2">MRVQHLDLRTIPFHILPTTVSLDKYLSENFRSWEEKRDDCIVVTIWLIMLSYALISNILILIGIGRSSAMRTATSYWFIISLAVCDIVMTIISLVHLVPATAFHSAFLEFHSVRNIIMIFFYDLFWYTAVLQLGLMAFNRFVSIVYPMEYKWLFSPRKSLMIILLGYFLGLMVSLPSLFPCCNTLWNSYFYITVYDPMDTWYKYIDMCVNSLSLVAMIISYAIIIYKVRKSSKAMAKYQLTIRNKVSLPAFFIFLSLHKFKSRMKEESFSNIYIVQPPRNQVSKKEMRLFIQFFLVSVVFLLTWTTWQWLPHIFESKWAYFVMTSLFFINNSVNPTVYLFFNTQVELLFYKSFFIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3U9</accession>
    <name>A0A0N4U3U9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5777</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3U9"/>
    <dbReference type="STRING" id="318479.A0A0N4U3U9"/>
    <dbReference type="WBParaSite" id="DME_0000141701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000141701-mRNA-1"/>
        <property type="gene ID" value="DME_0000141701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000141701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30260" checksum="91F5441516AB1FA2" modified="2015-12-09" version="1">MIWSSQNVSSQPWEVFVINPLRPSKKIRALILLDTGSQQSYISETLREKLQLVAREQQTITVSSIKNSPEVPYLDSGSKKNVRKDSGGYDSRLGKIFVGKTCNQRLQGQQETCRSLLTFTVLIEQDLSQFWALETIGIADPIDLIDDEEAYEFEKSVRRNDEGRYAISWPWKSPDPKIEFGDDKIIEPAPSETPYLKYYIPHLPVIFPDKCTKLRIVFDASAASRKGYSLNDQLYKGPTPGWNCFKAAIGKIYSNGYREGFPSSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3V4</accession>
    <name>A0A0N4U3V4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5783</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3V4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3V4"/>
    <dbReference type="WBParaSite" id="DME_0000142301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000142301-mRNA-1"/>
        <property type="gene ID" value="DME_0000142301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000142301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25683" checksum="0B0B6412A1B49810" modified="2015-12-09" version="1">FLKPTVKSTTDGKWLSLFFTDKYVFSNHHICENLHIDGMNFVCTEQYYMYWKATVKEILLTKDPKHMKAIGSRVKNFDQSLWHRVALQVMAIANVRKYQQNPLLRMELFRTEKTVLVECNPRDCIWGIGRGMDEPDVCDFSKWRGNNLLGFLLSHIRDRMMKNPIYNDEVSLIFSTFFYFFSRSQLHFFSIFCYFIFFHFIIILYYFIYLIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U481</accession>
    <name>A0A0N4U481_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5937</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U481"/>
    <dbReference type="STRING" id="318479.A0A0N4U481"/>
    <dbReference type="WBParaSite" id="DME_0000157701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000157701-mRNA-1"/>
        <property type="gene ID" value="DME_0000157701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF76">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="270"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000157701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53548" checksum="104CCDBF1DA3C17D" modified="2015-12-09" version="1">MFLMKYEIATNYYDYLADDSQREYGIAGELMNTFNSSPVSSKKKRSSRKFQRSLSLIVSKEELHDYTQSMKSSWSMGAAIHESKSGTNSKSQNYEEVMVVVKNDDKENIPLSVNQKQHFLNEKQQPSNFVIPIQRKSPQQLHDLVNEDIDVTITPQKELLCLAEPGIAGCALANFGGSDANKELKIAISPTRKRKKSYDIVDLSQNLIELDVEENKGLKRNNTSTCFADFREYSETNPSVSYYSESFFPHINGFQGINVDKLCQLMESVKSKDCILVDCRYPYEYNGGHIKGSVNIYDPTTVQEFFFPECPNRFMDISSKFPILYCEHSKIRSPRIAMKIRYLDRLLSKKHDELVYSEIGLLQEGYRAFFKYKKQYCEPQGYVPMSGKKSFSDFPIMPITHLLRNMNCKCFPDNEKHELSEHPLDCPRRRQLRRSRTAPTETASNPFLSLKTPPQKRAMTDLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U483</accession>
    <name>A0A0N4U483_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5939</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U483"/>
    <dbReference type="STRING" id="318479.A0A0N4U483"/>
    <dbReference type="WBParaSite" id="DME_0000157901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000157901-mRNA-1"/>
        <property type="gene ID" value="DME_0000157901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000157901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14793" checksum="26FC4D4EDAD73661" modified="2015-12-09" version="1">MGNDRTTYVHFKGKFNISVISVYAPTLSANDCHKDKDKFYAELQLTKSQPKHNMVIIALVSHAAVTMNSVIGKYGIRGSMQQQRTPSLSRHLVAWNSPDNQYSNQIDYILVNHRWKSYVLDSRSYRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U525</accession>
    <name>A0A0N4U525_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6288</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of epidermal growth factor receptor (EGFR) signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lst-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U525"/>
    <dbReference type="WBParaSite" id="DME_0000192801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000192801-mRNA-1"/>
        <property type="gene ID" value="DME_0000192801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20035at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15731">
        <property type="entry name" value="FYVE_LST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043269">
        <property type="entry name" value="FYVE_LST2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000192801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57301" checksum="2F7108FD88AEE90B" modified="2015-12-09" version="1">MQSLLRLVNKPRVDDWSPLAKFYYADEALNAVTSELDSFDGRRDPERCNQLVAKLRQAQDRLLHIISEMLLIVFPRESDRVSRDYRIKFPDEIIHDSLPGQLWFGAECLTAGSNIIDHEAESEAIRPMARELTRHLDHLRELLKIQSLKGTTHYPDKIKTSLKIFDHLFAEFELNYVSAMVPVKTVREHELQLNLAVLFSESLEYAIKVGYITHDSIDDCDPNLMVALPRLAIVCGLLHFPGGILDIDGPTENIPEMFRAYVGIMYRIRGLLRTLDPDELRSLELSLCKGDSSFCDDSDPHSETLTISAFLCKTRSKSFSEIGDSADAVGIRSHYRSSADLIHRLFVCIAGVADQIHIQYPSDTRRVLKMVLQPNEMVPVYEIPGQTALIAENEEETGVEVQEAFPLPTFVGVRWVPDADCEQCTACGAPFTLVRRRHHCRNCGRIFCGKCSTNSLALPELGYDRKVRVCNLCFLYKINPFSPGENQNRNSYRNNEEASSEAFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U533</accession>
    <name>A0A0N4U533_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial</fullName>
            <ecNumber evidence="7">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aminoacetone synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6297</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:20738"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="7"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U533"/>
    <dbReference type="STRING" id="318479.A0A0N4U533"/>
    <dbReference type="WBParaSite" id="DME_0000193701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000193701-mRNA-1"/>
        <property type="gene ID" value="DME_0000193701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="59"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000193701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45722" checksum="1BC4DC5EF941C197" modified="2015-12-09" version="1">MGSISFSLLAFLPGLLVVFSIFHIVSTLLGQDAGTYKYERVIFGKQGMEIRVVNQDKALINFCANNYLGNFKGLSSHAKVIEAGKKAMDSHGAGMSSVRFICGTQDIHKALEKKIAEFHGREDAILYAACFDANAGFFEVIASEEDAIISDELNHASIIDGIRLTKAKRYRYKHMDIQNLEEILKETQGCRRRIIATDGVFSMDGDVAPLKEICNVAEKYNAVVFVDECHATGFFGKTGRGTEEQLGIQGRVDIINSTLGKALGGAMGGYTTGPKAIIDLLRQRSRPYLFSNSLAPSIVGSSLQVLNMLMVPNDFTRSLQSNITYFRNSMMQAGFKVLGDPDHPICPIFLGDAWLASRFADEMLKEGIYVIGFSYPVVPKGKARIRVQISAAHSREQIDRCINAFKTIGKTFKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5B3</accession>
    <name>A0A0N4U5B3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6388</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5B3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5B3"/>
    <dbReference type="WBParaSite" id="DME_0000202801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000202801-mRNA-1"/>
        <property type="gene ID" value="DME_0000202801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000202801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42553" checksum="86A113B6E078C5AD" modified="2015-12-09" version="1">SFLTSVKLLFSGLRAIAEGKVAAVVLAGGQATRLGASKPKDCNSLFALQAARIARLQVLAAKQFPSYRPIIHWIIMTSASTEADTKRHLEEIAQMSELTMDQITIFNQGELPCITFDEKLILSSKSKIATAPDGNGGLYEAIRPHLPRFRSIGIRYFHVYCVDNILCRVADPHFIGYCIEKNADCAAKVVEKVDPGERVGVICKEDGKIKVIEYTELPRDLAEKRTESGKLVFRAGNIANHFFSLEFLEKVCSDDYPIIYHLAFKKIPFVDENGTIIKPNSENGYKLEKFIFDVFEFSQNFFVWEVPRAEEFSPLKNAENAGKECLSTCLRDLFAEHRRWLKCKSDDDRNLFVHPNNQVRISSYSLSVQFISYNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5L3</accession>
    <name>A0A0N4U5L3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6504</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5L3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5L3"/>
    <dbReference type="WBParaSite" id="DME_0000214401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000214401-mRNA-1"/>
        <property type="gene ID" value="DME_0000214401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5811893at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000214401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20849" checksum="5A571642B1AD36F6" modified="2015-12-09" version="1">MRCNKLRPESGVVVYRVEPETSPFDVTPLSGDVFSRYNILNGRYHFDIVATDSFGQEARTSAKVIVEGDVDQRYLKKFTSEFFSDHCDEKIENLDRIRRDMPNDIIFSLREDQPLGWLNKRIILLPHEKIANAPVEKEYVTIYSNGSLMLIKQLNYEIERKIKFAVHIENPLRSKHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5M4</accession>
    <name>A0A0N4U5M4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6518</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5M4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5M4"/>
    <dbReference type="WBParaSite" id="DME_0000215801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000215801-mRNA-1"/>
        <property type="gene ID" value="DME_0000215801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871495at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF365">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000215801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39033" checksum="4C15A1E85D127EBC" modified="2015-12-09" version="1">MGQHSDNGMFQKYTEIDMKNFRRLAFSAVALSTVTMLSCIIFAPLSYQYVQRLQSNVLNDMDFCKSRNRDLWYEVIAVQLAKGQNDKAKRTIEYANINSPRLFAELIQKHINHRQSSKALYHRQRRDTDSFETDEENNVTGHETDHDRPKATDDAINEIRKPTTISGKYKKLCCSCTIGPPGLPGEPGIDGENGKDGKPGLNGTPGRDADLRSPIKLCIQECPPGPPGPAGQPGDKGPRGYSGETGEPGPPGVPGENGPPGIQGSPGLVGLPGWPGNIGEPGKRILGIAPPGPPGRPGIMGPMGPRGLPGTDGKTGKKGPPGRRGDDGSKGPYGKPGVTGAVGADGPPGEPGSCDHCPTPRLPPGYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U768</accession>
    <name>A0A0N4U768_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS45</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U768"/>
    <dbReference type="STRING" id="318479.A0A0N4U768"/>
    <dbReference type="WBParaSite" id="DME_0000281601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000281601-mRNA-1"/>
        <property type="gene ID" value="DME_0000281601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000281601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11532" checksum="FA81C953B5988FBD" modified="2015-12-09" version="1">MRLFSYSWLKVLKKNRELENEIMKDVPGWKTGTWYGEPVYFTLGDKWWDPGLLEVFAHSDSNANLKEQMWRHHSEYGAPKFYDKYIPQFIADRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D1</accession>
    <name>A0A0N4U7D1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS119</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="17">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="17"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7D1"/>
    <dbReference type="STRING" id="318479.A0A0N4U7D1"/>
    <dbReference type="WBParaSite" id="DME_0000289001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000289001-mRNA-1"/>
        <property type="gene ID" value="DME_0000289001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="76"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="19">
        <location>
            <begin position="628"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="756"/>
            <end position="757"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN50146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000289001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="947" mass="108927" checksum="749178C3700DAFED" modified="2015-12-09" version="1">MVIHRVSRIFAASSRLSTRSSNISYQLMLEKGFIHPSNKGLYSVLPIGDCFIFNNYNCKSSTIEISSVIFNDNNKRVIEKLVQLIENELNSIGCQKMCLSILGSKQLWLKAGRWDRMSSEIFHLQDRQGKYFCLQPTAEEMFAQIVAQRGNIPLSNFPLMIYQTGLKFRDEMSPKFGFLRSREFIMNDLYSFHLCDEDAKVIYQCVSEVYHRILRDLLKFRLYVVKADSGNIGGNISHEYHVPSETGEDRIVCCDQCGAGVSWEYYQKGEKPCETCTGAISIIPSIEVGHTFQLGDIFTKALNTTMNRNYLLMNCYGLGIGRIVAAAIDSLSMASSVRLPEKITPYKIGVIGPMDSSMCCDEMHLFTECLLEQLDSIPQLANEVLFDDRIYKSYGSRLQFASSLGIPYVVLIGNASARKFSERPVVEFFKMDSSKTEPVALGLLTHSELFYQLMQSVFIRKLNIFEKYDHLSKFQVLLSVVNNLTDSCVRQMEQQIFFPPEAVRGIRQLTDKERELFRKEFDLPAVRIPQNYVKDIRQFSRFFHLTIDRISSKIKNIICDPQSFDKFLLFHPCRFDDVQKQWVIEELYDLFKEKFSIENFHLIVNYEDWHPKHCIKAVLPKELEFSGFSHIGHIIHVNLRENLLPYKNVIGQILLDKIASCRTVVNKLNIIENEYRCFEPDLLAGEANYETVVKENKITYKLDFSKVFWNSRLSTEHTRLVDKLDNTCVVYDCCAGIGPFVIPAVKKGVQRVLANDLNPICTKYLAENLSLNNVRIINCNFIIFFFSISNLFHLFYFFHFLKEIVASDIVNLIEMLYSSNDPTKSSLEEVFSPTFVIYFHCYIFVKSNTDVDEEWYIEEAKKLITKNLRESNIVEIHNVSKVAGRKMLYCISLQLLSELLFSSSTQSTDAISNTSEQILSSSKRKCTDGEVTALNQLEPLDKKAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7E7</accession>
    <name>A0A0N4U7E7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HSF_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS136</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7E7"/>
    <dbReference type="STRING" id="318479.A0A0N4U7E7"/>
    <dbReference type="WBParaSite" id="DME_0000290701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000290701-mRNA-1"/>
        <property type="gene ID" value="DME_0000290701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN50163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000290701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47069" checksum="AC1F86A3D77F60FD" modified="2015-12-09" version="1">MIKMIIFLQSGYSFHIVDPYTFCRDVLPSYFKHSNLSSFIRQLNMYGFKKITPIDKTGLFNTESDRDHIEFSHPFFMKGHPEFLQNIKRKVSRVTESTPNTVTIQATDLSVLLNEIRQLREKEKAVDAKLSNLIKQNETAWEQLAHMRNMHMKQQHVVNKIVQFLVVLVRSSQTRLGKRNLLAIDEVGGKRARTSTPVSLGRQDNNLTEVLDRLQKVVAGESELTFFNQNINTIHNQGPIIADVTDEPDTSSNSTPSSAYRKDSAAKKIIDNKRATASSKETDPTLAQEIFLTPVIDRQLSDDLAEFFTDQTHCIDNCREFLANNWDVFNNFMDEKDHRQNQEEQEKETRPQVQQQQLMLTGADPPLALNNIPNEYNDNLLNFDPDLFLDVPISSPCSNLVTPSATPKSVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7L3</accession>
    <name>A0A0N4U7L3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7140</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7L3"/>
    <dbReference type="STRING" id="318479.A0A0N4U7L3"/>
    <dbReference type="WBParaSite" id="DME_0000298101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000298101-mRNA-1"/>
        <property type="gene ID" value="DME_0000298101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="8"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000298101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61645" checksum="F7EEE69B46B2F910" modified="2015-12-09" version="1">MKEDEIRYDRQLRLWGDEGQHSIAQADICVFGSSALACEILKSLVLAGIRSFLIVDSEVVTNPDLGSNFFIEKTDLMQPRAKIAELNPSVEGKFDLRSAEQYISQNSDSLSEFSVVIASNLLQRTAYKINKYLFIKNIPFIYARSYGLVGFVRISVKEHTVTDCHDENPLPDLRIDEPFEELASFSDEIDLGSLKYDEHSHIPYLILYIKALKVWREKQDQKHAFPDTYEKRKDFEQVYLSLRKPKAEGNLHDEENFSEGRAAIIRSLHKTCTPKKTQELLEHPKAVDPDHSQFWIHVAALRRFVLQHNKLPLSGQLPDMISDTKTYVRLASIFRQKAICDAKEVYRNVCSILNEKGYSQEFFKFNDCKQFCKKASMIRVINGSLIESETNMEYPECLIENIRNSNFSRHHISNVLCIPPVLWYLLIKAVDRFQMEKSRFPGTNGVPCIIDSHDLKQRFSAILQSSQIIDAAEVLEKVPEEVVSEMCRYGNAEIHVIAAFIGGIVAQEAIKLITHQYLPLNNMLIFDGHTQQGSIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Q9</accession>
    <name>A0A0N4U7Q9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit tim-16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7191</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulates ATP-dependent protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Q9"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Q9"/>
    <dbReference type="WBParaSite" id="DME_0000303201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000303201-mRNA-1"/>
        <property type="gene ID" value="DME_0000303201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000303201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14192" checksum="B0752CE73E9C3BC7" modified="2015-12-09" version="1">MAWRAAAKIVVAAGEALTKAFARAVREEFQMGKQAASRHAEQIGASQAEAKIASDTNSRLGISLQEAIKILNVSDPLNAEEVEKNYKHLFEINDKSRGGTLYLQSKVYRAKERIDEEIRNMKKETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U864</accession>
    <name>A0A0N4U864_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog subfamily C member 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7373</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U864"/>
    <dbReference type="STRING" id="318479.A0A0N4U864"/>
    <dbReference type="WBParaSite" id="DME_0000321401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000321401-mRNA-1"/>
        <property type="gene ID" value="DME_0000321401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000321401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12299" checksum="166B14DA2BE1787F" modified="2015-12-09" version="1">MSNLVFYAGIGLAAIGFTGRYLLKHQHRIKKAAEALPIASLSKYYRGGFETKMTRREASLILGVSATAKPDKIKEAHKRIMIANHPDRGGSPYLAAKINEAKDLLDSTRFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8A3</accession>
    <name>A0A0N4U8A3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8A3"/>
    <dbReference type="WBParaSite" id="DME_0000326101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000326101-mRNA-1"/>
        <property type="gene ID" value="DME_0000326101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5789289at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000326101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16785" checksum="7136F5D935B6F8BC" modified="2015-12-09" version="1">MNKEIRGVPIKKYFTNLASKDVEIEENNVAFRCVNNRFHVYAIIFIIWGILAVVMFSTALFSTQTFLDTFGQGHHEQFIVRFFIVIIIKIIIILVGLFLIYQCFVFNLCRKYFDHIRSIDLPMQEATELQDISEKNQILQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8S5</accession>
    <name>A0A0N4U8S5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS328</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8S5"/>
    <dbReference type="WBParaSite" id="DME_0000346201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000346201-mRNA-1"/>
        <property type="gene ID" value="DME_0000346201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5815589at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000346201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37255" checksum="A37ECD14CF970543" modified="2015-12-09" version="1">MMQFGIIFLIYSPKNHLGSCEIDILQQPPRFDNGERLLSITPCAYPIPSNIFDCGISDIELLQDIKLCDPDQTISMSEVEAIKEKLEKINSQQRDNCVCKYSQRQPCWYRFGFAFIRQIFPVETGVSHLYRESLQRYGDSYARILRERWAFGECDEDILFLIVQKRSQQYIFASFGALVIEELENEISSSLYSKHNLDQFQKTINKENDKLKNGYPLKTVIEQLLDEIELRLTKVEQLKAFKTGNHIPNWAIAVFVVCALLCLLMTIGLCLVRTSVRRGAPRAKGIHTTRRWKAGFICENLEGNATGVNLMQMMLPPSRNYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8T9</accession>
    <name>A0A0N4U8T9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS342</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8T9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8T9"/>
    <dbReference type="WBParaSite" id="DME_0000347601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000347601-mRNA-1"/>
        <property type="gene ID" value="DME_0000347601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="95"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="17">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="316"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="671"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN50369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000347601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="785" mass="89121" checksum="7A33A901657DFC17" modified="2015-12-09" version="1">MDVGRFLLKSCVAIHLDNNDEKFFLLVYMAQKLMALVKGECSPETLDNPHSEILHTLRSHRISEFTRSLEYFLATGNLMSHALFAFQQNSGFSVIAERINYLRFVSHFRAIHRGAFFTQMRTTDVRKLRPEAWGFICPVHTPDGAPCGLLNHVTADTDVVTHYSDNKGVISFLDEMGMLRHNNHFFLADVEIYSVLIDGNFVGFIRFDDAALIEKRLRYAKVSVDDSRVPYVSEIVLVKRSPDPINIQGQYPGLYIFTDPARLIRPIRNLKLNRTEYIGTFEQVYLSICIDPNEAEEGVTLHQELYPSSLFSFSGNLIPFPDHNQSPRNLYQCQMAKQSMGVPVHAWNYRADNKMYRLQFPQNPIVQLDNYKKYCINDYPIGTNACVAVISYTGYDMEDAMVINKSSYQRGFAHGSVIKVERINLAAESGDVNRYFFADPQKSLKSIDTDGLPIPGRLYMEGDPYYSFLELETNSFKVKKFEHSEPAYCGLVRILEADDLVNTKGKCHALIQWRIQRNPIIGDKFASRHGQKGINSFLWPVESLPFSESGVVPDIIFNPHGFPSRMTIGMMIESMAGKAAAMHGSIYDASPEKHTAIDYFGELLTRAGYNFYGNETMYSGVDGREMEVEIFFGIVYYQRLRHMIADKFQVRASGPVDPVTHQPIKGRKKGGGIRFGEMERDAMIAHGTAFALQDRLLNCSDRDISNICANCGSIISLMNQPRGSFSYSSKKVIDHTERCFCLICNKDDRVHSVQVPRILRYLSAELAAMNVCIKLDVKHPSQMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U917</accession>
    <name>A0A0N4U917_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7563</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U917"/>
    <dbReference type="WBParaSite" id="DME_0000355801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000355801-mRNA-1"/>
        <property type="gene ID" value="DME_0000355801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000355801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9188" checksum="064FC52F5763B357" modified="2015-12-09" version="1">MRSDSISMKYKANFDILKVLLPKLFLDFYGLLTNDHQGYIIGNIRDNNISLSKNIKITTNQCASRMLVKVLITVALCSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9A8</accession>
    <name>A0A0N4U9A8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7664</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9A8"/>
    <dbReference type="STRING" id="318479.A0A0N4U9A8"/>
    <dbReference type="WBParaSite" id="DME_0000365901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000365901-mRNA-1"/>
        <property type="gene ID" value="DME_0000365901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847693at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000365901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7405" checksum="CC45CC95D8D9B279" modified="2015-12-09" version="1">MNFVLVEGEIFLNDGEGLISNLDNIDHCMVKLGKCITKTSIGLWNSTDVVNNCPYRRVGKFENSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9B4</accession>
    <name>A0A0N4U9B4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7670</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9B4"/>
    <dbReference type="STRING" id="318479.A0A0N4U9B4"/>
    <dbReference type="WBParaSite" id="DME_0000366501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000366501-mRNA-1"/>
        <property type="gene ID" value="DME_0000366501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000366501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21502" checksum="06BF5F8974391EA9" modified="2015-12-09" version="1">MSHKIVVLGSSGVGKTSFINLICSRSASIPCSTVGCAVSVIAHQYRAGSAEEQTELIELWDIGGSLMHQKASSVFLEGATGAILVHDLSNSKSELSLVQWLTLIRGDNSLASNLVCSPSIIRPLLSDIENTPIPTLIVGCKLDLAPGRAKQSGYDRINVDCHREMPAGSTNRIVISRFFDSVVERKKKPISVGRRRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9R5</accession>
    <name>A0A0N4U9R5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7849</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9R5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9R5"/>
    <dbReference type="WBParaSite" id="DME_0000384401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384401-mRNA-1"/>
        <property type="gene ID" value="DME_0000384401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="496"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="810" mass="92802" checksum="5210D805598A0C09" modified="2015-12-09" version="1">MVLAFSRGRFTYFLDSILRPQDPLRESDYTEWKLFSARISRMCENDVSINVDSRIDSAITCGNFEISENIKADAAYYREETDELYVVFQSLNHRITNICSYRMVDVDRFLKKLWDDCQHEAFVNNLDRCTKIDISQNVPLYCFVFTQRTDRRPVLSCTRYGADFSSQPIDNCNTIPYHSTAYRHGWIESYSPIKGSLFAIRRSVNEKAVVLWSKKSLLDSSFSFAIDVSLNLIVYVHRAHNQLSTLKISCSNFYDTCYALDDIAWMDPLKCVWCLTANRLGFAISLSQKCDYQVLNGICLPYIVHIGSYRFLFSGYPSYIFNNVAGPLQVIPSSKKSGTKYEIYGRKFNYLEEISVKICDQPCSIEIVQSKRHLFSILRIICTVSVSPYSPRGCAVLVEGDLQNFGPYNVSYTVNPVSDSPETSHSTKGTKRTKMLISIFSIIILAILILLIVWIIPENNAYTGHYSLCYNNKSLYSYKNLFMDIDPKLRISLNDLEIHDEIGKGNYGIVYKGLYRLKNGKSRDVACKTIDCHQYSVGISEFLREGLIMANFDHTNVACLIGISITENYCPIIVTDYMENGDLRHYIINPDNKLTFRNLLSFAIQIANGMQYLHSLNFIHRDLAARNCMMDANLTVKIADFGLSRDVSACGMYEAINKDRGIPVRWMPIESLEEQQVLILAKVLRYTFKADIWAYGVVLWELATRGLIPYGDLETSEIIRLLKNGHRLSQPKGCPNILYKKVMLVCWIEDPKRRPTFYELKEMVEDVVYQLQQGAPGNSLLNNHYERVSPRTVGTTAIDYSMHNPCITCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA00</accession>
    <name>A0A0N4UA00_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS7950</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA00"/>
    <dbReference type="STRING" id="318479.A0A0N4UA00"/>
    <dbReference type="WBParaSite" id="DME_0000394501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000394501-mRNA-1"/>
        <property type="gene ID" value="DME_0000394501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2107370at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="139"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN57977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000394501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37919" checksum="ABE24B5308CCC375" modified="2015-12-09" version="1">MFSSYAADCLRFSFASCIGENFHVILALFLRTHFILVSNLLFFFSDFGALDDLRLFSTFMAIFAFILTVIHSRRSELITRFDFIWKLQAIDEGKEMEKKHSQNRAVLENILPAHVAEYFLRENLTQRNELYHEGRDNVAIVFITITDFDKFYMELDANNEGVECLRLLNEIIVDFDTQLSRDEFKCIEKIKTISTTYMAASGLTGQVIGNAHVVAIAKFAIRLMALIKYINEHSFNNFNLRIGINVGPVVAGVIGVKKPHYDIWGNSVNVASRMDSSGVPGKIQVTEETKKILEQEGMECECRGVIKIKGKGDMRTYFLKVSDEDICIDFGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA25</accession>
    <name>A0A0N4UA25_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7978</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA25"/>
    <dbReference type="WBParaSite" id="DME_0000397301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000397301-mRNA-1"/>
        <property type="gene ID" value="DME_0000397301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000397301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25379" checksum="A2DDF721E6D54E0C" modified="2015-12-09" version="1">MQHFEIGYAYVDGKISTVLIAAMIESAGRTFFRFYHIPEEIIQTSDDEPVKLKAINETYEARGFTSQCYIDIRWHKIDIAFDKRPEVQSTGVYVFDMRYQYFTSSNFNTILIQFLPHGWSKLNPDGTPMKCFYFYREIHLIPMISNGKYLIVESEYVKNYLTYTNGNVVNGMINLNYVSHVIVKECPYRETSISTLELYNSFSNLAWIIRLELEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAA6</accession>
    <name>A0A0N4UAA6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS431</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAA6"/>
    <dbReference type="STRING" id="318479.A0A0N4UAA6"/>
    <dbReference type="WBParaSite" id="DME_0000406701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000406701-mRNA-1"/>
        <property type="gene ID" value="DME_0000406701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="247"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000406701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47250" checksum="E3AB7DCDE61CFA15" modified="2015-12-09" version="1">MFFRFKRPTEIQNAVISCAIKERCDLLGAAETGSGKTFAFAIPLITRLLEEGISKKVDKPLLGGLILAPTRELVMQIKRQIDALLKFTKFKIITIVGGLSQQKQERLLSYCPEIIVATPGRFWAFLQTAPSGNHLEDFSGLKCFVIDEMDRMVEKEISFCIAFLVYYIYHSDEKMQTLVFSATLTFVHPPPKRLISQSKHMTTDEKIQQLAAFAALRKNYKTIDLTRSFGTAERLVEAKINCANLLEKDTAVLYLLKRYIGRTLLFINSIDAARRLHGILKKPLMLHAKMIQKQRLKNLEKFAENSVLLATDVAARGLDVQNVEHVIHYQIPKTAELYIHRSGRTARASHRGLTILLVDLLDVQFYRRICQNLNREKDLSIFPIDSQNLYSALKERVGVATDLESVEYRIKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAE2</accession>
    <name>A0A0N4UAE2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7998</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAE2"/>
    <dbReference type="WBParaSite" id="DME_0000411501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000411501-mRNA-1"/>
        <property type="gene ID" value="DME_0000411501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000411501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12506" checksum="430E8BE6CC33464A" modified="2015-12-09" version="1">MASRMEAARLGDNRKLFYLLHKATMTRISQRSMVRDSNCVLIKSIKDCLIRWKEFFEAKLNHEAPSIAPDIADTFAEAYACNCEPPTEEEIISVIHKFKANKTPGEDGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAJ8</accession>
    <name>A0A0N4UAJ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8063</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAJ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UAJ8"/>
    <dbReference type="WBParaSite" id="DME_0000418001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000418001-mRNA-1"/>
        <property type="gene ID" value="DME_0000418001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097524">
        <property type="term" value="C:sperm plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043401">
        <property type="term" value="P:steroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF45">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="135"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000418001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47240" checksum="A6211E0D779A62D2" modified="2015-12-09" version="1">MALSIWATPLLYELLPNPTWLIFLFVFIAVIRSLKIFDPPNKPEVVYSRNSTKSSNYSIGDVLEKCEILHEIYSPPLIWGRNGHIQTAAYGLLGHASLKRTYDKRHVIELSDNSSVLFDVFEPINTHPSGGDYTLALCPGIANTSESNYIRTCVHYAQEKGYRCAVLNHLGALPHVRLTSKRIFSYGGTEELEAMMNRLIDLYPNTRFISIGFSMGGNITTRYLASMDFQAVKKIIIGLSVGQGYCATRSSALYHDWENCRRAYNYFITENMKRLLSRNYEMAVLPHVLDGTIDEQRLWSATSIVALDESYSRRILGYSSVEEFYASCSCLPFIPNFKFPMVFLNAFDDPLIPSCLWTPIKEIASKNEYIGFILTKHGGHLGFLEGNSISPNSVTWLDRFIVQLADAAVLTYDTTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAW4</accession>
    <name>A0A0N4UAW4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAW4"/>
    <dbReference type="STRING" id="318479.A0A0N4UAW4"/>
    <dbReference type="WBParaSite" id="DME_0000431701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000431701-mRNA-1"/>
        <property type="gene ID" value="DME_0000431701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000431701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44944" checksum="29FB8906DC456627" modified="2016-06-08" version="2">MEKKRNAMSDVERAQLARKLDEDLDLFIEELAKNKVFLIKKEKEDVDKKEFDFDDWCKDIDQHPAFMTDLKFNENGEYSEAVQALQALKYDEDESEDKIVLAQQYKDEGNKHFEHKKYRWAKDCYSNGINLSCSDRPINSILFSNRAAAEKYLGNYRSAIRDCAFALRFDPQNHKNADDKLSFLYLMVTMKQREEYINRINGLKIEAKNWALIEDRDSRKLKAKMKEENIAKSKLLVALASRGVNLSPKIDFSDVQSFEWSHLEIKLPAVEMPQRVYVDDSNILYWPILIVYPEFSFTDLLTDCCEEAILADVISPVFKESDERRLPSFNVADVHFFLSLTFPEGDIVEVFPTATILEILRTKDFVIKQGLPTIYVIFCLVSLMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAX6</accession>
    <name>A0A0N4UAX6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8213</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAX6"/>
    <dbReference type="WBParaSite" id="DME_0000433001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000433001-mRNA-1"/>
        <property type="gene ID" value="DME_0000433001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000433001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22952" checksum="52DAE06E70F89EFD" modified="2015-12-09" version="1">MLRSSNAVIYVVISVNRYYAVMNPLKYSLKFTPTIAYRVCCGILFISVLIWSPLALDRCSFYFNTELYRYGPRNSICSIRFWQALLFSSLASTVAAFIISVITLIQLKKSNKLILSQCSSAAAGNARRKRASTINKASTEKDMVIIGGDWNASLGDDANAMISTIGKYGIGDRCANGERLLRYAEKHELFVTFCYCNVASDIVETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB38</accession>
    <name>A0A0N4UB38_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myoneurin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8281</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB38"/>
    <dbReference type="STRING" id="318479.A0A0N4UB38"/>
    <dbReference type="WBParaSite" id="DME_0000439801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000439801-mRNA-1"/>
        <property type="gene ID" value="DME_0000439801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000439801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1339" mass="152027" checksum="30F83ACF5ADBEDE4" modified="2015-12-09" version="1">MEQSVDVVIRCGGKFVTSAHKLVLAAYSTHFEAALIAVQNSKPVTLDIDPDIIDVQKDSLLEIIIFMYTGRFKRPSRLTVKSVRDLGCHSLVHLLESEEARSYPDCVLEDSLHSHQLLQAAFRFYKYNSKFTDCIVNYQNTPVAQCHRLILCAYSEHFEMVLKNVNHNGIMNINIDPVDTGISSTDLRNIIDFMYTGCIRTTIKRCRVLRQSALALEVFSLVEAIDYELGVEDNLSRVEDYDNEQLSVTDKESVDNAVGINQSESDEALCERLQWFVQMQYLATLPEKELLRGNQNGEQGLQEGEFTSYSDIYSAFVSGPRRGRKGGSYGSTQESMRIKGSKEFFSNIESDVCGVKTEPLSVNGLNNSVKGDLTPAVTLSFTPSGKRYRMFDSFGYGLPEILGSKEITVPLLVGDQQVMMEKPFKCPFCDHRTKEKSAVDKHIRCKHTLETPYKCPYCNQGFKVQSNLVRHIRAHTGEKPYTCKKCGTTYADKKNMDAHVFRQHLKMKPISCPVAGCLAKFWRRDRLDLHCKKTHGCDSFYPNLGRMSDKDVEQHIQMNVVWAKLPEDIRIVLGNSQREYDKLILEYSIKNQLRYKGNIVRYVKKSEEMYYDILLKYSETHLMLYPYHLSDIVVRELRMTPFNYYINIIMDLINAERSYDSLPNFAAADAMRLLGIGRNQYIELMNQSRGTRKIFRKSKSLREMLPMKPVTISIEPWWILCPGSVLESDIKFLSKDEKDILDMLLDEGPQLVATLDANLVQKLYHRGLAYLDVPIKDSDYIFVPTLDGFVMNRVIGDYFENLLYQIFVAIDEQSTVAELSETLNIDLQLVKNAVSVFCRLGFAKKRVTGLENLALHSTWASYMVVTEAGLEDTSTTTITTELSELSTSFVNSGVVEDDDDADFNPVESANSVDLPSNISPVSNSSAVIPTPAATSDGSKRIAFFFDSSLTAFLMMGNLSPSLKNHAVTLFEVGKLSDESLENFTDELQNINHFVEGEAQRYSQHAQTLLLTIRSLRDKNELDLIRGESLLSLDHATRLRLINRAYRFVVSMAPMNSEACPLSLPSVAHFGPAVPEVASCWFRLYLYNILSDGPISMYIPKGRRITELPRSFWKSRRLLLTTSAHDPIIVSSYNCLVPLNDTLKTHAVFLQEYSVTTNDLEIVNVPFPFENSPDGEKNDFVDHPSVCLLAEKLSLQENCGYIVLLLKKMSNDMESILSMNNSIISKDPRKICAYRTKLYSNESLSDFVVFDCIFGIPLFDEKLNRIICDRIKSCALFDQNRSTIVQFANHGLTMSLREMIDNFQDYDDIKPIFAKENDPCYHPPIQTLLFNGRKTVVVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBQ4</accession>
    <name>A0A0N4UBQ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malic_M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8533</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBQ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBQ4"/>
    <dbReference type="WBParaSite" id="DME_0000465001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000465001-mRNA-1"/>
        <property type="gene ID" value="DME_0000465001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000465001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11558" checksum="8B5100F3BC6E4822" modified="2015-12-09" version="1">MQGRVLFASGSPFPNVELNGKIFKPGQGNNSYIFPGVALGIILFKKVASCVSDHDYSVGRIFPHLKRVREISVQIAVKIAKHCYNNPRHWVKFYRSEPIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD63</accession>
    <name>A0A0N4UD63_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9049</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD63"/>
    <dbReference type="WBParaSite" id="DME_0000525001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000525001-mRNA-1"/>
        <property type="gene ID" value="DME_0000525001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019207">
        <property type="term" value="F:kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF4">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GSKIP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000525001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16425" checksum="45505619808102B0" modified="2015-12-09" version="1">MVSWTESSQLNLIGDTKLVIEEISFAVKEISISNKLPQAPDLYQTRDLIFLVFIAPIFQILTGTKYCVEITHRGWRVTSNEYDNMHGDFEQLQLHIRYYESIYELLSALSPEYRKKFSDCLVEKLMEVKTQQLVENKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD91</accession>
    <name>A0A0N4UD91_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD91"/>
    <dbReference type="STRING" id="318479.A0A0N4UD91"/>
    <dbReference type="WBParaSite" id="DME_0000528101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000528101-mRNA-1"/>
        <property type="gene ID" value="DME_0000528101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866796at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1758" evidence="1">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000528101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="51179" checksum="5351EC8C7B981262" modified="2016-06-08" version="2">MAQYVSNGIREWKALINALNTNTHANIEEYKLMAIGHSKNGEDRRGVTETSTNNKAAEITIDEIRWIKKELISHILEGEAKELVEGFSMDGESYRNVWKILESRYGDKSIIIKELYKELRELNPKTKDIKDIRKDLKRIFRQLTSPASESYSRVKCMNCSKDQNTVLCQEKREERQQKIQQDQEQMIVTTANFLRENSIVNEVFFPCMEIFVINPLKPNKKIRALILLDTGSQQSYISETLREKLQLVAREQQTIPVSSFASKIPQKYHTSIEVGIILHDGSIFKIMASTMTQLTLQIKYMQLEGYQSSRTEVLGSRTDPTDLMDDEESYEQFEKSIKRNEEGRYAISWPWKSTDPKIESNFGLAFETPCFKYYIPHLPVISPDKQSTKLRIVFDASAVIRKGYSLKNQLYKGPTPIPHLAGIILRLRLGKFILMADIEKAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFD6</accession>
    <name>A0A0N4UFD6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9436</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFD6"/>
    <dbReference type="STRING" id="318479.A0A0N4UFD6"/>
    <dbReference type="WBParaSite" id="DME_0000614001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000614001-mRNA-1"/>
        <property type="gene ID" value="DME_0000614001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040996" description="RNA helicase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="259"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000614001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52978" checksum="314C08386712B45F" modified="2015-12-09" version="1">MVIYFFVFLISFFLQNSGYNEKVSFASLGLGQWLCKQLKELSIKHPTPVQANCIPQILSGLDVLGCAKTGTGKTLAFALPILQQLAVDPYGIFALLLTPTRELAFQIAEQFVALGAPINCKIAIIVGGRDQVAQAQDLIKRPHIVVSTPGRLADHINSDTEGIAKLFKKIQFLVLDEADRLLDGQYSVELKTILSSLPRKRQTLLFSATITSALSQLHQVSVKKPYFFEDKSEIATVEKLDQKYVLCPQAVKDAYLVYVVKNFYENRPESSILIFSQTCRECQALAIMFNGLGFQVGSLHSQISQKDRLSSLTRFRSRRIRILICTDVAARGLDIPRVDLVVNHNVPRLPKTYVHRVGRSARAGRFGGAITFVTQYDIVLLQEVEKLVGKKLEKLNVNDKKVTQYVTQVLVTKREAEIKLDKQNFGEKKAINKRKELILCGLDPDEVEKEIKAQREKRYVLSCWIFIFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFH0</accession>
    <name>A0A0N4UFH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1079</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFH0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFH0"/>
    <dbReference type="WBParaSite" id="DME_0000618201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000618201-mRNA-1"/>
        <property type="gene ID" value="DME_0000618201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000020">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000618201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44246" checksum="8BC1B1A19154A16A" modified="2016-06-08" version="2">MLAMGCCDCLTHFALHHPNRQRKRSVVDAFKDKRYINFDGKRRISADVKNALADDHEWTFNVLHLERITENHALSQLGIKIFERWKVQETLRCSDDIIVRWFNTMEAHYHNVNPYHNATHAADVLQATSYFLDSPTVAKNVEDIHATAALIAASIHDLDHPGRGNAFLINTRQPLALIYNDQSVLENHHVALAFQLSLQPSNNVNIFARLTRDEFIALRQAVVDMVLATDMSRHFEYLTKFQQTVDTLQQLLKNCDEPRNSVSISICRMMIKCADIGNPTREWSLCYKWAMRIVEEYFDQTKEETEKGLPLTMALFDRNTCNVPLTQCGFIDMFARETFTSWSEFAQLPEILTQLEKNYERWKRQTIEWNPANNHNLLSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG24</accession>
    <name>A0A0N4UG24_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9529</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG24"/>
    <dbReference type="WBParaSite" id="DME_0000641801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000641801-mRNA-1"/>
        <property type="gene ID" value="DME_0000641801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720939" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000641801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27866" checksum="7E6B82E682B60A76" modified="2015-12-09" version="1">MNSRNLLQFLLLTSYLPFVEVQNRSYRERLLNDKTSIFSGIAFLIIQFNTRRKTTTTAPHVPSVPQSLNQKTPEISLGIRKVNSSRETPREDENVRVLSQAQTQIPPNSPIRKMKCFEVIWWNNSLRIEMNESNHSLRTEITSLTSERPTNEIASVLSPMERVSTIKPQQIRANQFSLSQSTNEIVKKASPMIDTNMPGIRPRKTVASWLNRYRYNEFKQISERIMREKWQFIVENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG38</accession>
    <name>A0A0N4UG38_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable deoxycytidylate deaminase</fullName>
            <ecNumber evidence="8">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9546</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Supplies the nucleotide substrate for thymidylate synthetase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dCMP + H2O + H(+) = dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG38"/>
    <dbReference type="STRING" id="318479.A0A0N4UG38"/>
    <dbReference type="WBParaSite" id="DME_0000643501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000643501-mRNA-1"/>
        <property type="gene ID" value="DME_0000643501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000021">
        <property type="entry name" value="Deoxycytidylate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000643501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19416" checksum="00FAA1ED0DE36F37" modified="2015-12-09" version="1">MYIKFSENEPCKEIQAKRLDYLSWEEYFMAAAYLASRRSKDPSTQVGAVIVDSDKKIIGSGYNGMPNGCSDDLMPWGKISESFLANKYAFVCHAEMNAILNKNCVSTKGCTIYTILFPCNECAKLIIQSGITEVVYAYDKANKMEFIAAKRMFDIAGVSSFYSFSLWFLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGQ6</accession>
    <name>A0A0N4UGQ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9716</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGQ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGQ6"/>
    <dbReference type="WBParaSite" id="DME_0000669001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000669001-mRNA-1"/>
        <property type="gene ID" value="DME_0000669001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="198"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="404"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000669001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="65415" checksum="B7A500183F5BD2AE" modified="2015-12-09" version="1">MGPDLEPLKLDFRAGKIVAGEEQWNSTVAQNETRKSCGLMRFELEQNIRKPTINEPFSITKARKKMKNEERTKKDFKGLYGVYQSSARIVIDCPKKEYLHYEGMRYPSFDIPLITDEWMNRKSRNDWFTICRRNDWQRCLLTFAAFFTSSASNFNNPSFDSKIVFSWQECMDHIDDIIVINLMELECKSPTIIQAKSFKSFGCDRHLFIVAETGSGKTVAYIVPIIKDLLKKRREGKKARAIVLVPTKILKMQLGRMVSNLIKNTDLHLIYSADCVTLSSDWDIFVSTPATATKILKEMTNVDYLVIDEADILLDDSFVDVMVDFLNIVKIRYSATNKTENEIYQTFSEGARVIFSSATCPKSLLDLAENVVDKDCLQFVSTKRFHHLMPHVIQKFIRVTEADKIKQVEKIINDDLGKSKGQTMIFCKDVKTCYYVTQTLQNLASDPFLMGGTMDIKQLEVMNKAFIEEPRIFVATDVASRGLDLPLLRHVINYDFPRHMVDYIYRSGRVGRISSKYSCKVTSFIHCPWEIELIRTIEKCVRFDIPIPNVEVNIAGKLIERKKNEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGZ8</accession>
    <name>A0A0N4UGZ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1404</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGZ8"/>
    <dbReference type="WBParaSite" id="DME_0000679001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000679001-mRNA-1"/>
        <property type="gene ID" value="DME_0000679001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000679001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11611" checksum="3B74FEF56B631A6F" modified="2015-12-09" version="1">MVMKSTRSEDLMGEKVDRCIADSILKICGGLAIGIVSSVALFKGRLFPVWFGSGVGLGMGWSNCRHDFQSPFLLHGRKILTDHINSSNNSKAEYTILIEPATFHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHC5</accession>
    <name>A0A0N4UHC5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9779</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHC5"/>
    <dbReference type="WBParaSite" id="DME_0000694701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000694701-mRNA-1"/>
        <property type="gene ID" value="DME_0000694701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000694701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7787" checksum="5A8D8F108A71EF10" modified="2015-12-09" version="1">MNRRRSVCIEEGDNNGTVDINECFVQKVVNQMNVKRPSPLAQSCKNNNDAFCAALFDVTEANDLQNNANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI85</accession>
    <name>A0A0N4UI85_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fes1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1723</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI85"/>
    <dbReference type="STRING" id="318479.A0A0N4UI85"/>
    <dbReference type="WBParaSite" id="DME_0000730501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000730501-mRNA-1"/>
        <property type="gene ID" value="DME_0000730501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000730501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43413" checksum="2F0E331B1F079C2E" modified="2015-12-09" version="1">MDENGINNAYWKMILELAQSVVGENNSNHSMKEVKQLDSKDKQFIEKAMQETVRKVDSNMIIASCLRDLRSLMNPSDNDLDFVTNIVNTLEDVICQIDFAYNFCRMGGIEEIMRFMSLPLLSVKESIMRLIPTIAQYNPQAQDYINGSNLLFTLVENLLVADQASAIKYQCLSGISAIVRNHHQSFEYHLLVGGPSSHFWYRVITKPGFEQAKNNDNAPSVGLDKANTFVEPCVYNCEPPTEEEISIVHKLKKFINMNGLNIVLNCYQQALEKHDERVANKAAVIIVGIGFDIGFQEASKHGFTDAIFEIFCTIPPSFDACSYVRGYLNYPELQNMKLTSEMIKAMQDALQSHLDYETTLAEKDENTINELRATLKSFNEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI86</accession>
    <name>A0A0N4UI86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1724</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000029">
        <property type="protein sequence ID" value="VDN51751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI86"/>
    <dbReference type="STRING" id="318479.A0A0N4UI86"/>
    <dbReference type="WBParaSite" id="DME_0000730601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000730601-mRNA-1"/>
        <property type="gene ID" value="DME_0000730601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF6">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="47"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000730601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23927" checksum="2B01786B0EB26719" modified="2016-06-08" version="2">MVIIGSERRPINLFNNCEKSLFEDEKIDFDTSSQSSNRFIPNEWTYAFDKMINDENGRIQFTKFLQSEYSEENIFFWLAVQELRPCIDDRPRFEKRVQEIFDKFITANSPLAINIDHDTRMDIIEKIQCMDSSILTEKIFDRAQAHVYRLMEKDCFSRFIHTPAYKDIAKRLQLPRNFQFSDKQLSSLKCTFQVSDNKTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIR4</accession>
    <name>A0A0N4UIR4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1776</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIR4"/>
    <dbReference type="STRING" id="318479.A0A0N4UIR4"/>
    <dbReference type="WBParaSite" id="DME_0000750901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000750901-mRNA-1"/>
        <property type="gene ID" value="DME_0000750901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000019">
        <property type="entry name" value="LiPocalin-Related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF7">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232800" description="Lipocalin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin" evidence="2">
        <location>
            <begin position="189"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000750901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40274" checksum="B69D5CC25D7ED7E7" modified="2015-12-09" version="1">MVVVTLFTALLLVSRIYSYRFPRQTAINAPSFQSFSKDFVLTKEQKSELKKIGEVADNILYRLGISTDGRNRRYKPSPSSEYHLDELNSVINEANENRIDLQDISNGQIPGIAPIPVPGFPGPQDIKPIAGVNTIPGLKNFNYLVAQLFPQMIPPTNTLLGASISRLLPKDSAKNLAKDVFRAIHPAAENVDVARMMGRWFQVINSPHVINEACTVSHFGALTNTTYSATFTILKFYREGNANGPPRFSLGYGFKSGDTGQFVLHSSNSPDSEPFWVVKKGPLNEYNQYDYAIVSNWVRFPVFVIARDPERFRKEHIKNVLQFLEDNSYINVMTKAFNMISPVDYSQCQYTPTFSGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIS9</accession>
    <name>A0A0N4UIS9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1793</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000032">
        <property type="protein sequence ID" value="VDN51820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIS9"/>
    <dbReference type="STRING" id="318479.A0A0N4UIS9"/>
    <dbReference type="WBParaSite" id="DME_0000752601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000752601-mRNA-1"/>
        <property type="gene ID" value="DME_0000752601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="ZnF_GATA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcription factor GATA-3"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
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        <property type="entry name" value="Transcription_factor_GATA"/>
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        <property type="entry name" value="Znf_GATA"/>
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    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
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    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000752601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33542" checksum="7495A9AC128C4581" modified="2015-12-09" version="1">MIVLSGNTSQLYQNIFFPTWTYQTNPAVNSGSTAINTSPPCPSTVADLNFAQPVITDPTSMIVAPSQPNTQNFFPQAAYPPYAPSEYYNPIHTANFLATQNRLAGPASACSPSCSAASSRSSNGVMIARAKPRNTTSEGRECANCGAVQTPLWRRDGTGHYLCNACGLYHKMNGHNRPLVKPKKRQSAQKRTGIECVNCKTSNTTLWRRNSQGQPVCNACGLYHKLHNIARPITMKKEGIQTRNRKISSKSKNKKRSPAETNFYDVLKNPNPYGDAMKFHIPTHPAYIPSAVQPPYQSPFMFSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIX8</accession>
    <name>A0A0N4UIX8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromatin-remodeling complex ATPase chain Iswi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1848</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIX8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIX8"/>
    <dbReference type="WBParaSite" id="DME_0000758101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000758101-mRNA-1"/>
        <property type="gene ID" value="DME_0000758101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="155"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="450"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="815"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000758101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="118807" checksum="135C9CD9F0053482" modified="2015-12-09" version="1">MSTEKVKIEIKDETLSDEDEQDDDETMEIDESLYNTEETNQEIQFEKDSYKRFEMLLKKTENFSHCLSAGDVEVTTASNKVGSRICYIAQPARPPPPYIDIEGDHRHRKTEKEEDEELMNLVKKSETLIRFEKTPFYIENGEMRDYQIRGLNWLVSLQHNGINGILADEMGLGKTLQTVAMLGFMKHYKNSSGPHLVIAPKSTLQNWLNEFEHWCPSLNAIALIGHADARAELIRNVILPGKWEVLVTSYEMVLKEKSLLRKFVWKYLVIDEAHRIKNEHSKLSEIVREFKSKHRLLITGTPLQNNLHELWSLLNFLLPDMFASASDFDSWFTTNEMMGNQDLVARLHQVLRPFLLRRLKSDVEKTLLPKKEVKIYIGLSKMQREWYTKILMKDIDVVNGAGKLEKARIMNILMHLRKCCNHPYLFDGAEPGPPYTTDQHLVDNSGKMVLLDKLLKKLKDQGSRVLIFSQMSRMLDLFEDYCWWRNYQYCRLDGQTVHADRQKYIDEFNRPDSDKFIFMLTTRAGGLGINLTAADVVIIYDSDWNPQVDLQAMDRAHRIGQKKQVRVFRFITESTVDERIIERAEMKLHLDSIVIQQGRLSDTQKALGKEDMLDMIRHGADQVFASKDSTITDEDIDTILEKAEQKTEALKQKISSLGESSLRNFALDAPGLDADGNYTVYKFEGEDYREKQKLVGGIGYWIEPPKRERKANYQVDAYFREAMRGGHTEPKAPKAPRPPRQPNVQDFQFYPKRLFQLLEKEVYLHRKTIGYKAQKQPDLPPKEAEKKQKEEQKKIDNAVPLTEAEQIEKAELLAQGLSNWSRRDFQQFIKANEKYGRKDLESIAKEIDTKTFEEVEEYSKIFWDRLEELADHERILATIEKGENRIQKRHSVKKALDEKIAKYKAPFHQLRIQYGTNKGKNYTEEEDRFLICTIHSLGFDKDTVYEELRQAIRAAPQFRFDWFLKSRTIIELQRRCNTLIALIEKEMGEAESVKRNRGQKSNANTANGVAGIDGKTSVSKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF2</accession>
    <name>A0A0N4UJF2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EH domain-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1984</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF2"/>
    <dbReference type="STRING" id="318479.A0A0N4UJF2"/>
    <dbReference type="WBParaSite" id="DME_0000778701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000778701-mRNA-1"/>
        <property type="gene ID" value="DME_0000778701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5972258at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="218"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000778701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="60411" checksum="5F3B1E4D717CD4C6" modified="2015-12-09" version="1">MSLVWRKIQRSNKKAAKYRFTIIPQELLIIGTNKWTPENVLVACLHRRRRVESKVRKWERGISDPCRGLIVWPEQTSDPLLFETTLYGNNVTRVYDDKEWILMVEELTRKGKHLPIGAVNLNMRLFIENSPGTGAELKLKLRPLWAEVVHCSIQILIYCSLVDEGEANIYKFKRHFIILAMNFREPVTNMIDEADTKISKTHDEIIKLRPVYNQLPEVVENEDILAWCQRITNGYTSVKITDFTKSFRSGLAFCALIHRYKPDLIGDFNKLDFSDLLCARRDNCRKLDAGIIATLPDRQDVLIFLSQLRSLLEGVSPADTKLKDSDHRVSALFALSESEAKLENLRKQREHEEAIDLTNIPIEDDSTQTTLDRMKRYGSMRGQELAETVARMAGRTVSTHLSSSEEEECLLKEHMRLLNEKDSLVRKSEYFNVLEQLHDVNDNIKQFSEDNRTEEDKQKTDAMMEELVGLVNKKDQLSQKDEEMGERDRLTLEAAAKFSRGFEQPISASKRLITWIRSEIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJN0</accession>
    <name>A0A0N4UJN0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10223</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJN0"/>
    <dbReference type="STRING" id="318479.A0A0N4UJN0"/>
    <dbReference type="WBParaSite" id="DME_0000787401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000787401-mRNA-1"/>
        <property type="gene ID" value="DME_0000787401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000787401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18395" checksum="E22AB56FE68E49CB" modified="2015-12-09" version="1">MVNSKGIRRGTRYMFSRPFRKHGIEPLSTYYRIYKRGDIVDIKGNGAFQKGMPFKAYHGRTGRVFNVTKHGVGVIVNKRVRNRIIPKRINIRIEHVRPSKCRQDFLNRVKENEAKKLAAKNGGPRIPIARKPKEPMKAHLVKTKGNKPQLLAPVKFEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJP9</accession>
    <name>A0A0N4UJP9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2021</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000042">
        <property type="protein sequence ID" value="VDN52048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJP9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJP9"/>
    <dbReference type="WBParaSite" id="DME_0000789601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000789601-mRNA-1"/>
        <property type="gene ID" value="DME_0000789601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000504">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000541">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="903"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000789601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147984" checksum="4318ECDD2947D552" modified="2016-06-08" version="2">MTSKTTSAGQLISRKRHLDDEENALGNGNSVDKIAFGSAGGYDTDVYGSVRGGRRSDYLSSINAGDDDDEGDDELMGPMATAKATYSASKRFVEEAARHGKDSDPFAETRIRTIAERQSNYQARAQHRQISPERADMFADQTPDIRDRSYAQIMKEQRLREETGKVEKELVDKAKAGELKSRPLAPVQKRGRWDETPKTEVLGAGALTPSSQTPGTTQRQRLTISSNISSIADIATPRIARWDETPAHAAGVDATPATGAKAWDATPTTQTPRRNRWDETPKESVRDGMTPGWGAETPRDTRTFEDAKVEETPGESKRRSRWDLTPSAATPLNTVAGSVTPSSTPLPGAATPSSFTPSAPGMTPSVMTPGGTTPVGALAIGLKTPVFPSAPMTPDQMAIFKWEREIDERNRPLSDEELDALFPPGYKILPPPNGYIPIRTPGRKLLATPTPLGATGTPVGFMMQGTPERPGLADKGVASLVDTQPKNSELPPLKPADIQYFDKLLMDVDESLLSKEELIEREIMTYLLKIKNGTPPQRKSGLRKITENARRFGAGALFNQILPLLMSPTLEDQERHLMVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNVDEYVRNTTARAFAVVASALGIPALLPFLKAVCKSKKSWQARHTGIKIVQQMAILMGCAVLPHLRSLVEIVETGLVDDQQKVRTITALCLAALAEAATPYGIEAFDSVLKPLWKGIRSHRGKGLAAFLKAIGFLIPLMDAEYASYYTREVMLILIREFASPDEEMKKIVLKVVKQCCGTDGVEAGYIRDEILSHFFKAFWNHRMALDRRNYRQLVDTTVELAQKVGSAEMIARIVDDLKDENELYRKMVMETIENIISLMGANDIDARLEEQLIDGIVYAFQEQTQEVQDAVMLDGFGTVCKGLGRRTKPYLPQICGTILWRLNNKSAKVRQQAADLIAKLAPVMNICQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKSIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGSEFVSAREWMRICFELLELLKAHKKSIRRAAINTFGFIAKAIGPHDVLATLLNNLKVQERQLRVCTTVAIAIVAETCAPFTVLPAIMNEYRVPEINVQNGVLKALSFMFEYIGEMAKDYIYAVTPLLVDALMERDIVHRQIAMDAVAHLTLGVYGFGCEDALIHIFNYVWPNMLENSPHVIQRFIFASDAMRVSVGPIKVLQYCLQALWHPARKVREPIWKVFNNLILGAQDALVAGYPRIPDTERNTFLRYELDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK31</accession>
    <name>A0A0N4UK31_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2179</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK31"/>
    <dbReference type="STRING" id="318479.A0A0N4UK31"/>
    <dbReference type="WBParaSite" id="DME_0000805401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000805401-mRNA-1"/>
        <property type="gene ID" value="DME_0000805401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000805401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23793" checksum="DBB67B6C14BF7D69" modified="2015-12-09" version="1">MKQNSKIFSDRSGSRDRSESPRRRSRSRSTEIAEQLCRLHICNFDESIKKNDIEDAFSYVFYSFNNKLVAFFSYQTNFDLKKFGEIDNIWLASYPPLFAFVTFKDKDDARDALKEMDNAYIGRNRIKVANAHPPRRPGERRPPRRYGGYGGFRGGGSRYGGGPRYGGRSGGYRGGGPRYGGGDRYGGRRRDSFDPLEKGQRTQESIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK56</accession>
    <name>A0A0N4UK56_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2208</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK56"/>
    <dbReference type="WBParaSite" id="DME_0000808301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000808301-mRNA-1"/>
        <property type="gene ID" value="DME_0000808301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842689at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000808301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22449" checksum="8A7D0D9FC8908BE5" modified="2016-06-08" version="2">MTAAADFRARNVSSNNRSQRRIIPEEPHPFLLKKEKEKKQEKRYQSLPTAFENITETEEEATSTSDYSSSTSLDGRSPYAVRQEDCSCYIRPVTQTAFFSHPLISPKLGRRSASDKSSNRLCRGFSDPVVRKKRSFSSLMDRLSDSGSFDQIYNDFLNLPPIPEISPPSRHNEIDESKGFVEQLRVSIDSDDSFELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL09</accession>
    <name>A0A0N4UL09_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2431</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000060">
        <property type="protein sequence ID" value="VDN52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL09"/>
    <dbReference type="WBParaSite" id="DME_0000845601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000845601-mRNA-1"/>
        <property type="gene ID" value="DME_0000845601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836372at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041035" evidence="4">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000845601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18729" checksum="17DD879F23AF9C73" modified="2015-12-09" version="1">MATIAMSAIFLLFFSKLIYCDTFKCYHCASILPESTASDARYALRSILYSAYNLPPVNKYCGDAQDIQFKTITQIECSSNDQCIKIFVRQEELSFVMRGCENSLYRDGVARMPFQCATNKSPAVCRCRENLCNSSSGWNYVFTYIFFFFIFNLLISNGFIIVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL31</accession>
    <name>A0A0N4UL31_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS2457</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000062">
        <property type="protein sequence ID" value="VDN52484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL31"/>
    <dbReference type="STRING" id="318479.A0A0N4UL31"/>
    <dbReference type="WBParaSite" id="DME_0000848201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000848201-mRNA-1"/>
        <property type="gene ID" value="DME_0000848201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF271">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="14">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="180"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN52484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000848201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48463" checksum="84AB75D7BC701ED5" modified="2015-12-09" version="1">MALMKECSKISSLPTVEKKGHKRNVLPDNLKNRHIDGRLAKFCSLSHGERLLECDAYFESTHEYYFERSSDLFEYIIDFYVNGRLHRPLDVCPIRMQNELEFWRIPITMLSKCCQLDSNQSMVASFSRNPSIFDEMRPQLFQLYHEASCSLFKNTWLGNQRMKAWNLLENPRSSLAAKSLSLLSAFFVLLSLAVLILASMPEFQDENQEPHWFLTHMEMSCMLWFTLEYIVRFAISPKKLVFLKSPLNIIDLLTIVPFYVEMCLPYIGIMHTVELRNIRGAMIVVRVTRLARVTRIFKLARYSTGLRAFGQTMQKSAAELSMLGMFLLTGIMLFSTAIYFFERDEPNSKFYSIPAACVITMTTVGYGDLVPATAAFPISMIIDKFAESTAICWDDPGAQISQFELLRMKRNPRKGFFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL62</accession>
    <name>A0A0N4UL62_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anillin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2493</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL62"/>
    <dbReference type="STRING" id="318479.A0A0N4UL62"/>
    <dbReference type="WBParaSite" id="DME_0000851801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000851801-mRNA-1"/>
        <property type="gene ID" value="DME_0000851801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5915976at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF23">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="2">
        <location>
            <begin position="108"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000851801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32740" checksum="D36E70C51D56F13B" modified="2015-12-09" version="1">MSYSELKSSSSNSSLPLPPTNPVLDQRNYEKEKARIEKAISIQQEQIVQASHALSFCHQTQEFRGSREEVDAQRALLIATESRRALILALDHLIQDRSRGIRKPLDSPRGTLIINNISVKLLRDFINGHINNNSQLYYFIILIRHGETIRNTILLTSDYGLKNGRLEFPHYIQLNSLPHDFICTFEIYALRTRREVLGHYEKYHIKNSGSTKKKPSVLSSTASSPAGSSVIDPSFQRVGYLTLSLESVKRDKFRLNEALFPLDGLIEMHLHCYAEGTNAVGYRGFLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL70</accession>
    <name>A0A0N4UL70_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS10394</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL70"/>
    <dbReference type="STRING" id="318479.A0A0N4UL70"/>
    <dbReference type="WBParaSite" id="DME_0000852701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000852701-mRNA-1"/>
        <property type="gene ID" value="DME_0000852701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="296"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN60421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000852701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="84370" checksum="4A9BE631FCB1CFE6" modified="2015-12-09" version="1">MDRVNVGMHVDIRRSDGRVHTAIISEVRKESQSVTVEWFENVRFYEFFAIIESNKCFGLEGETKGKEIDLKALLAINPVLAIPVAEAFAEGSRNGLSNHSRQQISTAFGNRRSMIVGQVSQSCETDLAKALLDQPNDTARVSMHFSKNVTQKQRINLDTTSLKGFKGADLESLDAISLKGTQQQHQQHQQQQSKSSTVQEIERLQRNREERRAQLAMQFIPLSMACLPPYATFNICCEFNLLLFLFFKKEVKKQKEQQKNIDPGNPNWQFLSMIRDYQSQIDFRPLKMTDQVTDNRICVCVRKRPLNRKEIMKKEIEVITIPNRDHLIVHQPQVKVDLTKYLDNQKFRFDYTFDDNVTNEMVYKFTAQPLVKTIFEQGFATCFAYGQTGSGKTHTMGGDFSGKAQDCSKGVYALTAADVFKMLHKEYKRQNLHVYCSFFEIYGGKVFDLIGNKAMLRVLEDGKKEVQIIGLQEILVKDEKDVLDLIKKGNEVRTAGTTSANANSSRSHAVFQIILRKKSEKHGLGRMWGKFSLIDLAGNERGVDTISSDRQTRMEGAEINKSLLALKECIRAMGRNSVHVPFRASKLTLVLRDSFIGSNAKTCMIAMISPGMSSCEHTLNTLRYADRVKELGADEGSNIPMEDDELMLANDDDDFDLIQSTNMGMSEEAYKMQRTLQSVARSEERSLDELTSIFEESDKVKSDIMLLLNRASKVEYDMEGFVIDLDKFVTQQIEKYMRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULE3</accession>
    <name>A0A0N4ULE3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULE3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULE3"/>
    <dbReference type="WBParaSite" id="DME_0000861501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000861501-mRNA-1"/>
        <property type="gene ID" value="DME_0000861501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000861501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15448" checksum="61F968C247450769" modified="2015-12-09" version="1">MANHLSLSSIVSSRTPTDEILRSSTASNLTPTTSVEIHHERNVHIANSAKNTIPKFITQPPDYNQIVPTLKSNKEQMRKCITIDLLTASQREANFLRMIDRKASILYKTNVVLNAIRRYECFWLPMQVKIKLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULL2</accession>
    <name>A0A0N4ULL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULL2"/>
    <dbReference type="WBParaSite" id="DME_0000869001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000869001-mRNA-1"/>
        <property type="gene ID" value="DME_0000869001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000869001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11877" checksum="940E37036A1CCD07" modified="2015-12-09" version="1">MDTACRHSKSVQIQSRASYLEYLDVVLFANSHDEMQVMLNKCQQLQQELDSGASSSLVGERSPSSTIGVDAYFVTCNGWCQKRGRPVKNWADTSEKNFERIDGPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULN2</accession>
    <name>A0A0N4ULN2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10446</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULN2"/>
    <dbReference type="WBParaSite" id="DME_0000871301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000871301-mRNA-1"/>
        <property type="gene ID" value="DME_0000871301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012085">
        <property type="entry name" value="Globin_nematode"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002026">
        <property type="entry name" value="Nematode_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002026-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000871301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17451" checksum="8FD3732B985BB0F8" modified="2015-12-09" version="1">MAGKTCVKSLENVKVGLGAREIENGTDLYAYLFDTHPEFRKYFKGHENFTGADVKKSDHFKKQGQTLLLACHCVASLHEDPATFKAYCREIIDRHVKANVHLDPSLWSAFWPIFVDYLARKTSIDENAKKAWLDVGKAFAEECLSHLKTLGLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMM0</accession>
    <name>A0A0N4UMM0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tissue factor pathway inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10608</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001228">
        <property type="protein sequence ID" value="VDN60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMM0"/>
    <dbReference type="STRING" id="318479.A0A0N4UMM0"/>
    <dbReference type="WBParaSite" id="DME_0000910401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000910401-mRNA-1"/>
        <property type="gene ID" value="DME_0000910401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000005">
        <property type="entry name" value="Pancreatic trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="307"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000910401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49780" checksum="F905F98F1D2140E6" modified="2015-12-09" version="1">MVEATNIQFICSFSANKADESQSSERPAFCALQSETGPCRGSFNHFYYDPQVRDCLLFAYGGCKGNSNRFAFYEECMDVCGERTSMQDLTMPTGSDMEMTDLMDQNKSNNYRDQNNDPEIGDQVTYSERIRQQNEQKNINEDKFIKQSSSYPQTALPGGFLNFVFSIQILQRKSKEYNENALELCLLPEDRGPCFGEIVRWRYNSEISSCVTFIYTGCDHNANYFTSEEACERACGLFRNQDVCSMRVNKGSCNLGITKWYFNKNLGECHVFMYSGCGGNGNRFSSKAECQHLCSLETKISEDEDICKFERDSGPCIDAVTQWYFDKEDEQCKQFTYGGCRGNQNRFNSKDSCEKKCAQKRKNRTLIDAQNSVLKSTDSDSNKKYYDELRTHKDAKLTIQQNMFQSCSDASKDEMSFSISLSNATSTRPFQIEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN34</accession>
    <name>A0A0N4UN34_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3020</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000097">
        <property type="protein sequence ID" value="VDN53047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN34"/>
    <dbReference type="STRING" id="318479.A0A0N4UN34"/>
    <dbReference type="WBParaSite" id="DME_0000929801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000929801-mRNA-1"/>
        <property type="gene ID" value="DME_0000929801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000929801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="53725" checksum="275C82E2DC024628" modified="2015-12-09" version="1">MIDDEEHSLISRRVIRSSNFRSKHFQCRQSLLTELFEKTDISILWNLFLAFFLLLHLLTIIVDYLSTGNPFDHLWLITWNFSYFPQTMFVWCLMAISILIPYYILKFWSDIPSKEINFLQQLPFFFIYFFYLILFFILSLNFIFKMRLKCACTFIITCENTRIAMKIHSFIRETFPLDITDEIQFPTVSQLYYYFFCPSFIYRDNYPQTAKRSWKTILIYFLQIIAIILFVNLIFIQMIIPNFAKIPCSTMNFAEFIQRIIISILPGFFCLLSLFYGLLHCWLNMFAEILYFGDRQFYSNWWFSKNMAEYYRNWNLVVHDWLYTYIYKDIAIVVGGKTGLIIAQIIVFFISALFHEYWFGVALRFFYPVMFVLYFVFGGIFFLISRFIRNLFVWNTIMWMNLLVGTGIFVALYSQEWYARQRCSPLFDNAFLDFIIPRHLWFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN49</accession>
    <name>A0A0N4UN49_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3036</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000099">
        <property type="protein sequence ID" value="VDN53063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN49"/>
    <dbReference type="WBParaSite" id="DME_0000931401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000931401-mRNA-1"/>
        <property type="gene ID" value="DME_0000931401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000931401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14471" checksum="B22B2AF50084C922" modified="2015-12-09" version="1">MNAEAGQGRQARQVINIDDANDKRTSPNQFNMNELKIGKTLTDIYVCIYMRVCVCVCVYGAFMLWRYVCTCMDGVCLHATIFARSVEFSVISAYYTNILIPKPKDNRSRAIFLTSLSSQALIVSIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN73</accession>
    <name>A0A0N4UN73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CHY-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3063</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000101">
        <property type="protein sequence ID" value="VDN53090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN73"/>
    <dbReference type="STRING" id="318479.A0A0N4UN73"/>
    <dbReference type="WBParaSite" id="DME_0000934101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000934101-mRNA-1"/>
        <property type="gene ID" value="DME_0000934101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="409"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000934101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57867" checksum="F73E320B3AECC5F8" modified="2015-12-09" version="1">MNVGREGDEGGEKWSFDNKADFQSNLSSDLNSKLIISPNRRFTAVKRKIQIVKKEELGLITQKSIYDSVILYLKRRFPQSVHSTDNDTNDTIIKFCYEITQPDWAFDVKKVKFLIRIGQDYPIKMPVIKVIDESLPFPLIKHIEKSISDFLFVSCFQNKYFIMENSNAYSCLAQQFIRWLDRSIFDLFLNGLKKTKLIYEARDAGISLFLPSQRAISDENKQTENVDSKGFNSSIEVRLHWINVNGNVASVTALQMTFGCKCIRCSSLTFFSCSDKDMVKQSCRKCSNGQSVRLIADIVHENSNIIGRLELKGCRPVDCVLLSSKFQYTCLACNREAFIEVNQGFQNITYDVTHKSWCFSCHAKCELKILAIRFSGNFHLIPQEDFTVVKSKVAKKKDVSSFSLVDGQPLPANGTCEHYKKSFRWFRFPCCGKLYPCDLCHDKNEKDHEMKFANRMICGFCSKEQPFQQSKPCVNCNSNVKRSKSSFWEGGKGCRDKIIMNRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN90</accession>
    <name>A0A0N4UN90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ac45-VOA1_TM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10642</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001231">
        <property type="protein sequence ID" value="VDN60669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN90"/>
    <dbReference type="STRING" id="318479.A0A0N4UN90"/>
    <dbReference type="WBParaSite" id="DME_0000935901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000935901-mRNA-1"/>
        <property type="gene ID" value="DME_0000935901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="7">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000935901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48004" checksum="526778381D4952D9" modified="2015-12-09" version="1">MEPFEIHLCNSGNIFKEFCFQCLMTNWPSYWTSDLNDLDEATLDSVRVLVFSIEDFTLASFNQYIGAYSIQSIDTPLVKWIKSLTVKFGTSEQLLELPVVDIVKSFADITSKPVLLIESSSFDDLEKKFSLPDLLKNKPFIAILTDSKHILKNTLKRQKRVSSDVGFEDEDVSEKDNKVSEQKNFRKQAKQRFRTSSSEQLPMPVVLPPAQKSKFKPSDKCLLYLETIAIKLYRKGSSVEQTLIESPENSYRWDSSYVSCDLSKSGAGSATLMFNSSRRLHWNLMQVKTLSQFTITDNSNPVMVPSDKESGPLNSLNIESVYRYGYACSATKAAFIEIDKEIYFGLGLNNVEVDLNAKIEDGSLLFGSDVSDCTGSFSVGSWMGIICSLVLTSILMFGYLMLQSVQTHDRFDDARQKGYTINFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNJ5</accession>
    <name>A0A0N4UNJ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3155</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNJ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNJ5"/>
    <dbReference type="WBParaSite" id="DME_0000947801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000947801-mRNA-1"/>
        <property type="gene ID" value="DME_0000947801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855206at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000947801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51097" checksum="0AA15E55B196AF5C" modified="2015-12-09" version="1">MADFLDGNSVGNRRTFFNLEDNDDTGSNIVDETEKKYFCDDDVDSDILLSSLTGTSPCKLAYERGLEIVVLNHRFIDEVGDYIRFMSLCKQLKEIDLAWNRLTSWAEIAVLMEIPNLQVVNLSHNPLKNSIDAELPYANHLKTLIINGINLPFTTIGHFVSKMPSLYELHISDNSLLGNLLDIPDGDVISETVQIVYFNRCNITIWNSVVLIKQLFPQSHSFFLCENPITSVTFIPEFKQLDIFNGISFLNMNKCLIDNWASIESLSEVSSLRDLRLQHIPLLNNYSSNERNHLIIGRMPLLETLNGSKITVKEREESERFFLRYYDNYEIKPIVYGALLARHGHIEQLCKVDLTPKMHAYVVVICEENGYTGNVKVRLSHSVSCLMRMLEKLTNIHHARMRIFYLSGKNPFAEELRFPNQKLLSLRVEDGDKFSVQVKWFCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNY4</accession>
    <name>A0A0N4UNY4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3297</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000120">
        <property type="protein sequence ID" value="VDN53324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNY4"/>
    <dbReference type="STRING" id="318479.A0A0N4UNY4"/>
    <dbReference type="WBParaSite" id="DME_0000964701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000964701-mRNA-1"/>
        <property type="gene ID" value="DME_0000964701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44277at2759"/>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
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        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
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    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="225"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF01553"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN53324.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000964701-mRNA-1"/>
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    </evidence>
    <sequence length="338" mass="39527" checksum="E3B4D1BE22F33235" modified="2015-12-09" version="1">MSWPNWIQPYVEVLLLWISWAIDYIDWDYLEYLAWLFLPIFIIFIIPILVLFFIYGCIIFLHIYRLRHRIREAYASSYWDGARISITSFWDAVGYVWHGYEIHGLENVPDSGPALFVYYHGTLPIDVYYVISKCLLYKKRTLHCVGDKFIFKIPGWGMLCKVFFITPGTVEDCIKRLKDGHLLCIAPGGVREALFSDSSRYNLIWAQRLGFAKVIIGSSTPVIPMFTENCRDAFRTPRWGRRMFRWIYEKTKLPLCPIYGGFPVKMITHLGKPIEFAFSSTPEEVKSRMLREVHDLIRAHQRLPGSIIRGILQRLFQFHTTADASSKAKTNFKSPLIF</sequence>
</entry>
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    <accession>A0A0N4UPG5</accession>
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        <name evidence="1" type="ORF">DME_LOCUS10772</name>
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    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DME_0000985101"/>
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        <property type="component" value="Unplaced"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60799.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000985101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8082" checksum="EB4032C498204687" modified="2015-12-09" version="1">MNGNYDLSVPFTNNTNKRDRSTKLKSFWFVAPRASVPPAGDGNDDVGRACVVLPVGVSLGADDVSASSALVIISFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ40</accession>
    <name>A0A0N4UQ40_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3629</name>
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    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDN53656.1"/>
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        <source>
            <dbReference type="EMBL" id="VDN53656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001010701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26139" checksum="DF3B326A1F7C4F54" modified="2015-12-09" version="1">METVATPYMVRGAIIEALNLPKEQFPYFNTGEDFINSFYLVGQCLPSLLSILIKTCLSDKINEWPIRLITSGASYRTFSSHRATDENINLYNAPQQMLVTLLIICNSAIEESLEYDNIINRLQKLFLIKLPLNCHIDNIPPDQLFNFESAASSLRTESNIEVARISRSGTYISNRLNVVYGSNIKTQFVFLVNAEINLTRVVATVFEDYMVDSKPIPSEIQYLLKSHCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQZ2</accession>
    <name>A0A0N4UQZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Papilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3912</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000216">
        <property type="protein sequence ID" value="VDN53939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UQZ2"/>
    <dbReference type="WBParaSite" id="DME_0001045801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001045801-mRNA-1"/>
        <property type="gene ID" value="DME_0001045801"/>
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    <dbReference type="OrthoDB" id="5781878at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22635">
        <property type="entry name" value="Kunitz_papilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040015" evidence="9">
        <location>
            <begin position="17"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1077"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001045801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1361" mass="150105" checksum="6DF89B3294B1D5AA" modified="2016-06-08" version="2">MRALFWLILLIIPILSYTWFSSLQRKIYLHSKSPPEADPDSIRAKRQAYQVYVGGDQSVTVDKSGQAETGLWGPWIRDKECSRTCGGGVQIEKRQCSGECTGASVRYVSCSIEECSETSKDFRAEQCSQYDDTPLDGNYYKWLPYPGKNKCELTCKPDNANFYYKWADKVIDGTKCENSGDDICVEGVCLPLGCDKKLGSAIKDDKCGMCGGDGSTCKTVEGFFDERNLSPGYHNIIRLPVGATSIRVEEMRPTTNSLGNSRIIEKNYLDLNEFMFIEQKVMIQLSNKALKIGGTIFEYDIRKNIHQPFETLTAKGPTNEELIIALLFQTGNKDSAIKYEFSVPLEQDLPYIYKPGEWSTCSVTCGKGVQSRESFCVDSKSQQSVENELCETSNSSKPEIEKPCETVNCEAEWYQGEWEPCSATCGNTGNKYRVVYCHTLFSDGKRMIVDDSNCTTERPEVMQSCNRFSCPEWQAGPWSACSEKCGDAFQYRSVTCRSAKEGEEGKLQPAEACGENEFEIQRACNLGPCEGLKFFTTDWQLCEKCNDTEDVRNVTCKDKIGRVYPLDKCLNDNVTKIPIDVRPCATSPPCIYEWHSSEWSKCSTECGHGHKSRRVVCAIHELEAKPETRINCTNEEKCNGTYYMGPWSECSAECDGGKQTRLIVCLNYDKRPVPELCDEATMPAVEQECNTNSCPTCNMSDFGCCPDNITFATGPNLEGCSNCSSSEFGCCADNMTIAEGSNKFGCPEYEETSGEEVEKTAEEKESDGLCEVMSFETGDSAKIECELAKVANRTLEDIQLMDNVTIENVTLHCSKSEFGCCPDWTTRAEGKNNSGCPIFVLGVCNETTNGCCPDEVTMARGPNFEGCGEPSCAGSLYGCCKDRKTIAFGPHYAGCERSSFPCEISVFGCCPDGETAALGNNGAGCGANCLLSKFGCCPDGITVSKGLHNEGCGCKYAQFGCCPDGKSSAKGSNYFGCPQSCAQSEYGCCPDGKTAARGSNKEGCPCQYTRYGCCPDGETPALGPRYDGCDDCRYTKHGCCPDGEARAVGPNYAGCPSTTITPFLFGGTVAPEKIVACSLPQNQGNVCHPGYKLVWFYDSTEGRCSQFWYGGCGGNDNRFATKEQCETICIEPPVRGRCYLPKVEGPLRCNQLSARYWYDYTTKQCGAFWWRGCLGNSNNFESWEECQNFCAGVGPLEVLSSSSIHHVVQPQPVAHTYSPIQPQRIPIDFSRDFDKSSKAQQQQVPQPESVGYSQISQVQQPLTMDEICRQTVDSGPCDSYEDMFYFDAFSGKCHPFIYGGCGGNMNKYKTKEECEARCGHLETSRNAVSAAQLPGRHRPDEIPSIIVEERPAVLPDNSRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR17</accession>
    <name>A0A0N4UR17_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3939</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000225">
        <property type="protein sequence ID" value="VDN53966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR17"/>
    <dbReference type="STRING" id="318479.A0A0N4UR17"/>
    <dbReference type="WBParaSite" id="DME_0001048401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001048401-mRNA-1"/>
        <property type="gene ID" value="DME_0001048401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="277"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="375"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="497"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="670"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="785"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="909"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="909"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001048401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1371" mass="154269" checksum="CCBE1E4A401E6313" modified="2016-06-08" version="2">MVSEFLAAMVSPHTETINSYPQQIRSTYRCGGHINNATGVIKYPDWMWFYYGRNKSCEWVISVDDNNNKFIEMNFTRFNLSSESSSETGSLSCLSADSKLTLRDGASSNSPLIGIYCGQDGSNKAVPTSPIHFSSGNAYILFQSSNDILINSGFTIQWSMVEKMCGGRLYGNEGSISLYEYEPNIKCQWHVNADPQMHIEITVDPIQLGSGVNRNCSLNSLEIFDGLQIDQDIRIMHLCSSETYPILARTTLPNFSVYFTSAFHTSFDDHNQLDKDCGGMISTDANGIFSGIIQSPNYGFNYFPSLDCLWLLDASFSHNFKDGGDASKPILGKYCNDRRPAAAIVSTGPKMVIQFHSDDSVSGKACEKHFTSRNGTIQSPNYPSGTSIPLKCTYVIIAERTKAIRVKFNYIGLNFTIRSCFYEIGNQDKSQDYVEFVGGHDSHSHVNKRYRCQRYPFVAPEGEIVTSAYRPLRIIYSSSSIENKGILFYYEQMDVGCGGVFEGESGKITSPNFPDNYLSHMYYFHKLYTCCYGTGEGDAALSGNTTDLVHGLNNRLRTMPRFPQYIEYMMKLTVTEVSFQLKRILLNFDVFELEVVPNREDCAYDGIEIYDSYKNDHEFGHFYGRFCGALQPPSVLSNGNQLTLVFKSDRSVSGQGFSANWKAVNIKNECDRSYTAVSGKIQIKVDKEHKSTDCNYHIALPTMKRILLKIENFSLPCEEGTLMIRNGVNEQSPAFSGLFRDSEICDEHPVEELRSQGNRLFLRLKTLNTNNYYFNIIYEQVDSNCGGLLNGISGALSAPQYPLKDSRTLNCDWHIAVAYGNRIVFTITSIDDLNSADHDGFCSSFAPNYIDIADGPIAKSLILRRYCKKEVSPPSVNSETNEMTIRYRQHGGSHFGSLFGFIAHYKTVCYNIHLSGYHGMIQSPGYLQRVYENRFCKWTIHATQGNRIRLTFHLFRISEKKSPFTPLCLSNYLELEMNSVENVTAVIDGKPISNTTERKFCDEIGVPLTVLSKNNLLQITFASNNPENHFWLSWSIVVVKWNATLAGCGGILLSETDIEIRIADLIATSTAYECIWTITSPLEKSVQFTIDEFAIFNGSADCPSDHDEQFNGIAFYSGLSNKSGIAQQIICTSVSSTMSYMSNSNELFVKLLVQQYLIKHDSNNRFFRAKVRFITRKAGEECGSMINVQIGQTLTIHSPNYPNPYSKSIACIWHINTAITHILQFNLTHYTTLGHHPRKLQQYTWRPKNSAYNYQNNITCQNPVTFIEGSISFYDGNSTTSELLERLCHTITEPQIITTTSNQAIVLFQGAPYERAYLSGDDETVHVIGFMLSISLRCGGSLIASTRMKTFQLHTFADDDECKIAIRADGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR80</accession>
    <name>A0A0N4UR80_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High mobility group protein 1.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3982</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000238">
        <property type="protein sequence ID" value="VDN54009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR80"/>
    <dbReference type="STRING" id="318479.A0A0N4UR80"/>
    <dbReference type="WBParaSite" id="DME_0001055201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001055201-mRNA-1"/>
        <property type="gene ID" value="DME_0001055201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000042">
        <property type="entry name" value="High mobility group protein 1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001055201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="24019" checksum="02FCFC60CF17D30F" modified="2015-12-09" version="1">MRESAKAPVRGKTSPYGFFVKMCYEEHKKKYPNENVQVPEISRKCSEKWKTMSDDEKRRFFELAQKDAERYQAEVAAYGGEDAIRKRKRVKKDPNAPKRALSAFFFFSQEKRPEVQQEHRDWKVGQVAQELGRYWKSLSEEERAIYERKAQEDKERYAEEMRNYKGGAKIVTTEGIINNGMMGMAGHEDVVEEDEVDDEVKMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URW7</accession>
    <name>A0A0N4URW7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4198</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000396">
        <property type="protein sequence ID" value="VDN54225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URW7"/>
    <dbReference type="STRING" id="318479.A0A0N4URW7"/>
    <dbReference type="WBParaSite" id="DME_0001079901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001079901-mRNA-1"/>
        <property type="gene ID" value="DME_0001079901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867782at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001079901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12268" checksum="6FFF6028117DC743" modified="2015-12-09" version="1">GPYNYLGAFTECTARGGFVTSVLSFNENSFINGLVGGSAYWIGLRKVGRTWMWQDGTAASFTNWRPSQPDGCCGPDVTCTIVNYANAGGQWDDAGCTTLWRNPTNIVCKRAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US53</accession>
    <name>A0A0N4US53_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4279</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000569">
        <property type="protein sequence ID" value="VDN54306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US53"/>
    <dbReference type="STRING" id="318479.A0A0N4US53"/>
    <dbReference type="WBParaSite" id="DME_0001088501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001088501-mRNA-1"/>
        <property type="gene ID" value="DME_0001088501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001088501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8810" checksum="B2BC68DA82ECD43F" modified="2015-12-09" version="1">MNDIERRPSSVRMGRRFTLNPLIFAKEERDARRQSLAQLKLSYYPKNAHRSSAICLPCISSNSLVFFVFAPFFEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q316</accession>
    <name>A0A158Q316_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5797</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q316"/>
    <dbReference type="STRING" id="318479.A0A158Q316"/>
    <dbReference type="WBParaSite" id="DME_0000143701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000143701-mRNA-1"/>
        <property type="gene ID" value="DME_0000143701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="92766at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000143701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="39276" checksum="0190E580AAD6CD9B" modified="2016-06-08" version="1">QLSYPCEFSPKIEVVKKRDDIQCLRGIAIIYVVLFHISPQIFPNGYIGVDIFFIISGYLITMILNRSKPLSLSVILNYFSKRIRRIFPAYYIMVIIVVFLAHNFLIITDKTALIRDARFAFIFATNIEKWIDEGDYFALGQRYEILLHTWSLAVEVQFYLSAPLFIFLRQYLSYYRSVMSTIFRFWQFFLGMINYICLIQIILNKRLNNFVFLIDEKQDKQETPIVWKMINVLSLLSLSPIFLIKLPQKPYRVVASLATTILIIGKWRCFTDNTSINSILIFIGNISYSAYLIHWPVIVFIKHNNDSNLLNYYGKLLINFNLLFTKLDLVPLAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q333</accession>
    <name>A0A158Q333_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipocalin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5887</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q333"/>
    <dbReference type="WBParaSite" id="DME_0000152701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000152701-mRNA-1"/>
        <property type="gene ID" value="DME_0000152701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5785631at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005501">
        <property type="term" value="F:retinoid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002449">
        <property type="entry name" value="Retinol-bd/Purpurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873:SF0">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041045152" evidence="1">
        <location>
            <begin position="21"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000152701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="960" mass="110362" checksum="5638F9A611AC9368" modified="2016-06-08" version="1">MKYLILLFHVFSSNFVFTNSQCLTKLDQLDLAQEQYNGSWFRIAHMGPAIDYLPQNLNTSLIKLIPEDDHIKMIEFYESNGICYGPLYGLWIKQVTGYIMQIKANDGTLFENDNEEMNIVLYGCRTFKPNGECLQGEETASILSNSRHPQTLALFKSAKHLEDNACIDILRLRTLNTYGPCGDDIVDIDQKLENAAIDTEGELIENECKARNFPRRKIGNFFHEPRMLTVIAFMDPILANEDLSHISCLFSTKNDAICEYIRHKTCYKSTLKQVFPDEFSIESSIELQLNNDSIIRIDWSGTLLWQNGDEYITYKCIDVNEDGTCDQYRIYVWSDEDLMDQPTIHTIYEELDTICVDPTDLIFLNTFPIDECDENTFIKEPSIKCGKMAPWSPINVQLLQGVWFFAADINADPKIYMQSAVVELKADETNHSNETLTIKFFAQRESDLICIGPGSGKVQLIESNSTINVQVEYQYGSLQEFPNSIIQWQNQVLYLDNQRMLLYWCFKRNENGSCLQYDVDILVRSRHLAYHDLSLLEPYLNAACVNQDQLRWFDLHSLCGVDISQTTRLRRMIMTLTHREIEKVGKWFLMSHYDRFQYITYALIGRLTVVERGKAIIKVYQSAARPGLAKECFRRMFVLFEEEDGDDFTYHLYFNSLLGPKSYMILRFLFLNRHVGVVHACMAYNKTGECIKRFLYVLSRHDSIDHTELMVLERIANSVCLPVEHLTHVSVHDRCIYDNYNIKLGTLICSSITNLVVPLIQGSEYKIKERFKNNTFFAIASSIPNQSKFGKCTESDVAIKLSVDTEMLVIVNGSELVLLSPFGLASPLIIQTAQYSGEYPCLNPINYEQQNIEGECMRNDTIELLLKEDGVYSLIPGDEELSYHNGEVGMNGSIAFLNDKFVVLYTGFKKGQLTIPEERRVTVWTRTGIKTDDDVRAVLKKICILEDDLDNKTGTSECWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3E1</accession>
    <name>A0A158Q3E1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6589</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3E1"/>
    <dbReference type="STRING" id="318479.A0A158Q3E1"/>
    <dbReference type="WBParaSite" id="DME_0000222901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000222901-mRNA-1"/>
        <property type="gene ID" value="DME_0000222901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000222901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59715" checksum="213A3A9064F55F2D" modified="2016-06-08" version="1">MSGEGKNEKKTVGDFNELGWYTLFVCITYEILIISQVSNLIYMIFGGAVADVVSCENEDFRNMTNEERCSKYEIHKNSSTCKYDGVFHSVNYEFGYVCSDARTVKMSTSLQMIGIMFGAMIFGQLSDTFGRRKTLMFGTVGLIISGTISTFANGIVFFTIARFFVMFFTGGKHSVSYVFMMETLPTKHRMWIVTVITYSPNYIVFTALAYITGDWRILSRVVAAITIIPLIMLIFIQETPRWLVLKEKIDEAREALITIGKWDGTNTPERLAEVDAVLDKEREHIRQNAGHPKKKYYTYHLFQYRQFAAYAIFFSYSLVTTSVISYGLMFNFEKLAGSPFLNTIIIGSMRYGINIIVALIDIRFMWAGRRLLHGFAMSFMALGLIIVFVIILFDLDLKSVIRITALSVSAMGSQIYILNAIAPSELFPTAIRNVGMGFVQTFNRVGNVIAPQIFLLGDLWNPLPYLVMGLMGWIEVVLFLALIPETKGKPLPDRMPDDDDDGEGKALENIRLDKVENEEKMPLKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3E5</accession>
    <name>A0A158Q3E5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6604</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3E5"/>
    <dbReference type="STRING" id="318479.A0A158Q3E5"/>
    <dbReference type="WBParaSite" id="DME_0000224401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000224401-mRNA-1"/>
        <property type="gene ID" value="DME_0000224401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051440">
        <property type="entry name" value="Goosecoid-like_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000224401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20257" checksum="90F189C80A18C717" modified="2016-06-08" version="1">MSLPYPYYFPPTERYRLYLDSFPTSSSKKICFPAPTVSYFNASLVSPFNHLHFNGKRKRRHRTIFSEEQLQILESAFQNTHYPDVMLREKLALQCDLKEERVEVWFKNRRAKDRKHKREVNLRSGSAGKINAESDESDNNLCDDEGSSKSISKKRRVNRSDDTKNVELIHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3P8</accession>
    <name>A0A158Q3P8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS78</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3P8"/>
    <dbReference type="STRING" id="318479.A0A158Q3P8"/>
    <dbReference type="WBParaSite" id="DME_0000284901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000284901-mRNA-1"/>
        <property type="gene ID" value="DME_0000284901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872354at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF9">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000284901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16173" checksum="EB17EFA5B9FF864D" modified="2016-06-08" version="1">MHICSIVFRCFSCASADYEILFDRFKNLKESLSYPHFGDICDDAEKLIAMAPIEICSTTCVSILEPQYFGGVQSMHTPYTYIRGCTGTIFTEVKNRPPEIDFLHNEEICLPLRLSQIWPTIQTDEHVQVFFILKILASNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4N5</accession>
    <name>A0A158Q4N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="20">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS9082</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the calsyntenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4N5"/>
    <dbReference type="STRING" id="318479.A0A158Q4N5"/>
    <dbReference type="WBParaSite" id="DME_0000528301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000528301-mRNA-1"/>
        <property type="gene ID" value="DME_0000528301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012272at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000352">
        <property type="entry name" value="CAlSYntenin/Alcadein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF2">
        <property type="entry name" value="CALSYNTENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="1 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN59109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000528301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="908" mass="101800" checksum="A8167FEF11A772F4" modified="2016-06-08" version="1">MAVFVFIAPIIDLGGADELVGMLREDRTIVSIVPELNVVSDTGPICHYELSNDSIDIIPFVAEITDEKRGRGEIRVKEGVHLDCSTPQFHLNLVAIRCSDEVRSESVPLRISIRDTNDHIPEFAQPWFTFDIDEGKIYTEIARLQATDKDCGHPYGQICRYEITNSLDGFPFAIDDQGVLRNTEPLNYTQAKSYILTVVAHDCGMRQSKSTLVTVNVREACVATILNVEDRISYFPGSGDKAIVPEANIVTCAASNSCTVKSVESIITLKSRHIYQGCDRDDIFSSVTQSRCGINPETISLLPVVKEADKEKSNLGDKYAFDGKMNAIIIPPSLVKSLIPQKFTLSFSIKHSKGSKAEQSMKQNIICESDQLNMNRHHFAVYIRHCKLEMLMRRESDAEAAFRAAEWRWNLPEVCDSQWHTYSILFASVDQVDLYVDGKKFLATDENPEILDDWPLHRTKQTKTRLVIGACWHGRSQSMAQFFKGHIASMLFLSNKVEQPQAVLCAHQCKEQLQFTAIDQLVPGEEAIFDKESSVLTLKANTAEDLSLLLQKVSYINMMQSPTPGHRGFQIKTTINCASGKSYSLNPTKGYIFVQKEIDPVLSISGMPIVKSDQQSVKTGARMLPDIKITVTQNFNGEEQEKTSEAMLDWCKVHLKPSRDMELEYFSSSATLIADSHIDFEHDKQGIFLKGKEKATVYRDILSRIHYFNIRADSFDKRIYSVQCAMNGGKISSNEFLITMIIEAPTHNNIANANAASGAEHDAEPGLEQINNNRLQNILEMDLPRPNALISRHGHAASQGVLAAIAMIVIVCVGFLLVLLVIGVLRMQDSPLPRRRKNRKNPENSMEWDNSGMNITINPLEQVEKNAADYFDEESSDDGESYREEGLTDDDDDVEMALPHVQNGRLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4T3</accession>
    <name>A0A158Q4T3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS702</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4T3"/>
    <dbReference type="STRING" id="318479.A0A158Q4T3"/>
    <dbReference type="WBParaSite" id="DME_0000565701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000565701-mRNA-1"/>
        <property type="gene ID" value="DME_0000565701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6515516at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF66">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000565701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="76446" checksum="6900FC58DB940738" modified="2016-06-08" version="1">MEGHLWLKGKGKEEVKNVLILRISQNCAELNRSIHLVDLRSFGEIPSDLTVGVGICEKMTSAGSTNALNQPLDENFIRRLIEAVKSQPCLYNPNHEHYGNRHANAQYRARVWQKLCVDLEFTEDAHILQTHWKRLRDRYLRERRKRKNNIISDSSHLESGNFTRERHVSESSSSGNTTSLAGSRYFEMMRWIEPYLADVTPSSSFGATNINPSDNCSNGATVQKGQSSGNRAAVVTTSENTDTFYVNRSNSTHSDHSEPALQQAGSKNEVMLSCFEQRDRQKLQAERTEPRNRDYTKSCGNIPNGSSGRTNTQSDPSPINASPSSSTTSSEIDVGSVPTISGQTITQQQSNIQRHPSQRILYTKAEVQPRSSMQTCDGSVYTLMSQGIAPSSSKKDVSLRTSDGNAVAMVIDTANYYQHGNQKMYRLVNVSEMNAELVPLSAGNAGSSTNEVKLITVPRIQSSSEVSHRRKRLAPGSLPSISNGRGQLGDDLILDDGTGNTIVEKTITIDQTSPISGDRLLLDHSVSASNILGHHSLQQVHIQNAGGSAQHGSVITSGHHVQLSHQINHPGSTQINVVAMRPQQQNQRFITQQLSVQQPHYTMLTNQSITNNQDEHLEFANSIATHLARLNDDEKAVAKMNIQRILMDARFGLGACARMIHDEELTEVATTSTTHEMIVNTQQHQDPSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5E8</accession>
    <name>A0A158Q5E8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1654</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000027">
        <property type="protein sequence ID" value="VDN51681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5E8"/>
    <dbReference type="WBParaSite" id="DME_0000718301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000718301-mRNA-1"/>
        <property type="gene ID" value="DME_0000718301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="585"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="736"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000718301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="787" mass="89340" checksum="C4055F3EA329C8F0" modified="2016-06-08" version="1">MIFVPFAWYDTFKDFFWHNSCLQRCSCMTDNYKKINGQCIEQKKVAENTVHERSLDSCLRGKCALLQEIFDTDCLLQERSCGQNMIFITAHKLSVQNDSNYFHCIVKCVCISGHYEKNGQCIKKSDISVDAYNPCDMEPCKPNEIVLDAGCHLTGHKCGTNMIFKIISQGINYPSISRYCIQRCSCKSEDFVPKAFHCEERDEIRLKQEMTSNDILQFCPRAIYNLEQDITDIGCRLTGLKCGENMIFVTMEQYFSENSDTIIGCVQSCRCKEGGYCELGKKIYDYDCALTDTECGINMIFVTVQRNNDAEYCIQICKCKSAEYIERDGKCLIKVISAIDQPCFKNANCALGDSITDEGCQLSGQKCGINMEFIPFVLNLPMNICIQYCLCDNESFVTNSEQCSKRNSSHLSEMNIINMCEAADEHWIKLNKYILKSVKYTAMSGRRPCYRRVNSPSQELLNISLLIMPCGLYVKGRSWTDHVLLNCLKGTCSLHQKILDYGCGLQGRSCGLNMTFRIIGREELGDTEIIGVSCTVVCGCASEFYEKNGQCIPKERQLIPLQYNPCTNRICAVGEIFFDENCRLTGQKCGTNMIFVITTHGTIFASNSQYCYQRCSCKNDEFIEKFFQCEKKATIHSINGIFHINFIEHCSPNYFKYGQEIFDSGCRLTGQKCAPNMVFSSVENVDTDCTQRCICAEGYDYSEDDEQCIKEWYCEGGYCKLGKVIFDNGCTLTSFKCGVNMKFVILEKIDSRNCIQECSCISNEYIAMNGECMKKGGTSPNYLESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5H6</accession>
    <name>A0A158Q5H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microtubule-associated protein futsch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1747</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5H6"/>
    <dbReference type="STRING" id="318479.A0A158Q5H6"/>
    <dbReference type="WBParaSite" id="DME_0000738501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000738501-mRNA-1"/>
        <property type="gene ID" value="DME_0000738501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874845at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026074">
        <property type="entry name" value="MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057480">
        <property type="entry name" value="MAP1A/B/S-like_MBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF12">
        <property type="entry name" value="ATPASE F1_V1_A1 COMPLEX ALPHA_BETA SUBUNIT NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25281">
        <property type="entry name" value="MBL_MAP1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microtubule-associated protein 1A/B/S-like MBL-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000738501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="859" mass="94095" checksum="4A582610EEEBEC6D" modified="2016-06-08" version="1">MESDADLLVLLPPGHSVGTIRTRRPVMYVFSGGDEDAAFFSVNGFSLLLDGGDCKEVPFWNLIRNYDKISAVIATRVSPNSLRGISTILRRKALAECHPNFGAFICNLPSRKTVLGDNDVAEMIRTLHDDLNTEGLKPIETFTNPKGEPITLYEVIGEGALSMIVLNPERGSKDFTALANALKTGEDFEKHCAAASLAILLVWTPSDISKPTTRILYPGACPLDKLYAALEKLKSLEYLRQATFISGATRERPVAPPHGYVPPVKPLNQKPPVVPSTRTSLVRRTPLTPSHTDNSLKSLSNNNVRLTKSTATTESPIKKTVKQPLSKSASAQQGRQSFPVAAKKLPTIPKSNAAKIEKKTNDKAGVGGAQASLVHQKPSQKANSTKSHKTESVIITKTAVKAEGKTNEIQKHLNDEIGERISNEKDRQIVENIENTHFEQQNLQTELDTPISETEINIENAPISETEVNIENSPISETEVNIVNAPISETEVNIENAPISETVSTESPISTHVNIDNESKAEIFDQDFSNGLSPVTTETEENEVRNQNSMQLNGFREMEFATANSSPHAPSSATYEDTPLLESTPLESLSTPIDNYDTNLEMKTGSDEDMLISPSSPKSEKDLNNITNNGDVKKNIANTNKAFNISREDNSVVDAILDDVIESLAGESEKNDSPKEDDFFTHSDAIYSSNNNAKLLEAQKLYEDSHATEQYLPPVTTTLRVRGRPSNSIVSKPKLSNPLYFDIVFIPHHGPHAALTDEHAATTFVSNIRSKRYVLSGQNAIKTYILDGIIAGKNSWNKPDMEIDILPTHDTNDLIAFDQLKAAEMSDAGINLRCSVERCTLRLSSGGADDICSAFKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5T7</accession>
    <name>A0A158Q5T7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2299</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5T7"/>
    <dbReference type="STRING" id="318479.A0A158Q5T7"/>
    <dbReference type="WBParaSite" id="DME_0000822301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000822301-mRNA-1"/>
        <property type="gene ID" value="DME_0000822301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877915at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="857"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000822301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1677" mass="185863" checksum="303D347F16E8E39F" modified="2016-06-08" version="1">MANASDCSSSRSLPPIHETLGHLRHNCVVPTLDESISIPICQANTETNSLTSSPCTVLLSANVSDSQILSPVQCVSTPQIINGNQIQSNAIESHEQEHWYILMHICAHIRIHTHRHRHKFTKVQILISTMEPSPFSQLNLNDELSPVMHQLSAQVHSMSPHFIQNIGNDQAINHDTTQQRMHETTIQFVNDEQRSLPIQQEIHYIKNDDSCDNGSLTNAANRSNEIVEENSQFLIDQNDLLDEKQLLPNRVAYVLSGFNNFISNGDMAQSSVSMQQVFMDPNIRNQTFSPNGQRCTTNHAYQLVSANSSVQLASTVDSHLKQKQNDEHTGTIKAHSRSSSTRNSRGSAKKQVLDLKNVEEEVARNVSQILSASMNQKLSSSGCNVNSLANGNSRVKNSSASSTAINSFHISDAVNTAKSVTSLTTARKFICADCQKSVSTHRNLQRHRMSCKSALSSSTKQRQFCSSPSASRFRLDATEATAENMVLTSTDNFSITSVAVCVANSTLSLVERASYTLSKSTPCSAQQLTVQTPVISCVSTNSGSMQQGCTEFLESSVDQIATHDNINVLTNESALDNHSMRSVSFIDADVDVGNDILQQNFLTSDYANNQLQSTKSSETIFRCESCNKTVSSNRSLKRHRSTCKRYQLDLIMKDSAQNGSTNLADNVQLSSNTDAASDVTDSQKCNLLYVINEISAAEEIVNGSSGGSTSLVQYSSTNSLRDSLNANVVRSTNGANNTSNVCGDCNRSLCSASNLKRHRATCKAANARVPSPIASSNKVSRPHMQLDNIHVDERERLILDRSYAAAVAASKQSPNARRRSINNNTPCYQKQTILDSHAQITVGEHLRAQHNKRRQQQQQLQKQILQQSKQQENQQEQLQQELLEQNVIKDQQFIKSEILKNERNLNIEERTPFDSQEYTSDEQIIEKKIGEKQISNGKCYQNTNDGREFNDESLDFESYCKMKLNEHESGMIPTMGNAHANPAFHSPAAINLPDLEMAGVDKIKNASTFNQRAIVVSRPLSNLSRCSETISDDGSASIQFNNTSNSGARSCSEFGDYRYECPECLKTYSCPKNVKRHRTAVHKVTSYQLNKMKPRRIHILSDSFSMDERPYEKNTSIILSKPDTSIAIVNHFSEKYISSSAVTVSASVNKNWSAVYTDSSAVKQISYQILDDERTGEDIAQISEFTVRNSNDGIADNNEGECKKPVAELAEADTTFAEECDQTNCPSHLSNSIVSNGNVISSAANSCFSNTSLYLTTDLNSLPQGQLTVPTSSSFSAQLPPIRGVVPLTTCSQSSLALQNISLMKKDQVNSLALDQRQQKSVLNQSSKQQTVQQKLVQQQIHHSPVHNSTVHSQTVRPKQAHVCLDCKRTLSSDYSLKRHRTTCAEVKAAAKAASGTAGQQPTYETPVATTPTTLIFTSNAIIESHQNTEMVPQTFASLEDDADSGVLCRVCDCWLPDQRQFELHCDELHPIAADPDSTTVSQVSDQFITPPNAFVFNTSDIILNSNVLAPSRKRSGVDDFSHSNKNGKHLCQACGKFYSSEWNLERHKRESCPLRVKRCKSNEDKTLNKFDLFQLLLVQRVKETIKLVSLESINLGNTDQLKWTDDCAIVIGDFRICVCRSSVDFAGSLELTHISLLAKACDGWHQKRREPVKTWTDTARKNFEHIGRPAIYGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q663</accession>
    <name>A0A158Q663_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2938</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000090">
        <property type="protein sequence ID" value="VDN52965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q663"/>
    <dbReference type="STRING" id="318479.A0A158Q663"/>
    <dbReference type="WBParaSite" id="DME_0000920101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000920101-mRNA-1"/>
        <property type="gene ID" value="DME_0000920101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868357at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000920101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129997" checksum="3DDE8A104B3B95E2" modified="2016-06-08" version="1">MLRKVLEHRFKYLQSTFISSMMAWSSTGDISIKYLPYQLSMVVYVPTMIENSGYYSIRIYQNSAYPIDTLRLQNIQINNQKGGRGGLFINLLSYKSVNIIKSSFQRNAVPSVILFLRQNIDHPNHKATETSASAASDILKSLTSNLGNSPLLNFEENRFEANKNLVSYFFLENHVNATVHKNIFSFNNSNRSGITTVEISSSESPLLFELEIFENIWSRNKGEWCLYIAALTRNSFIGNVIGNQFRGNQNVRGSVITGSPYFNINNNEFDNQHEQFDLEVEYMEHRPVNATHNYWGYDDVNSVEKRILDGKKDTLRGFAVVNPFNRKRATIIESCATVKNCSDHGRCIGKTSKITAGIDRCLCDSGFSGVDCSQISCSSLNDCFNNGVCVAPNTCKCYKGWLQADCSEPSCYRLANCSGHGKCISLNECECNPLYTGIDCSIPSTSCSINGCNNHGKCVNNECVCHNGWAAPFCSHALCDDLNNCSNSGICVEPNKCNCLPGYTGDDCSTCSGSTCSACPYQCIHGRCNSLTRKCSCLKGWIGNECEICEHKTCELSVILFVLPTAIGIHHSEDDRIAVYGIDFPKTHFGRYTCLYGSTAAEGFYISSSLIKCSIPRTTGPGRYLFNVIPYESNQAIPFLDKRLIHFTFYVECDSVDCKGSCLGPTCVCRSDQEGILCQQAKIWPKINREITVSALLMKAIEGKPYTAKIPAQEPNAIYNLNSDADGLKIDPQGIIIWKKPIGRDRPYFVNLTISTSNGKSLISWNLTVLPTYSPLVSKVERETKGSRSVIQGFIQFINQNFGHVPIRLLIYSGDKLEENIVVISSDDGRFLYPYVPTDNVTFHSVIAIHPGKSISSVLINSSNAFSWRDNDVNVYYEEELEASPGQTLMANYQIKNCGDSPLMGCTVEVIAPRDKIQLEKYGEYINIINPGYTISQKISFSTSPVLDSSILILQLNCVGVPKKIIKQRIEVPGSRIALDADPSEVVVVHILNKGLSFQEPLDIKFREEGGPLFLIFSNPAINNYKEYGSAGSMLNLYFGLRSLNNTERVVSGNIILSYRGKQILFIPYKCVNVGAVLFNYLVAINDELSLIGNYSELNDIEIKLRSASGIENKHQTRISGLDDLVQDLVPCCILSIFSIILIQLMMASSSPIECQYYSDKLHQWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6K7</accession>
    <name>A0A158Q6K7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TLDc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10881</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001265">
        <property type="protein sequence ID" value="VDN60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6K7"/>
    <dbReference type="WBParaSite" id="DME_0001035201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001035201-mRNA-1"/>
        <property type="gene ID" value="DME_0001035201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836025at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001035201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75515" checksum="17FA52BE1C4DF2AD" modified="2016-06-08" version="1">MWSASNMNPISNETISEREDRAELCAMIPCLALLREPMQEFSICIFRQLRFDDKTDPTFYQTAPTFLLDNFDNSENEENQVESAVNNDNSSQDFITNKESKPKQKKEKSAVGRVISSNIEQYDPNIHLILYTPLSISTKQGVELITNKGQIWLRNIIFIHSYKGERLHFDNLKRIVDTDPIINYGVYRKEKNGKPSIFVLKMSIKENILEIERLTLLCSAKPSEHFYSTESRVYNNICKAVMLNESHSKGDDGKMRESLSQNSKLSLTMEYGMKYATNGNIDIDEILHIVISKTSEPSPKRIVEPLISFTSLPTNMPSPIAYQEFVKIGDRSIEIKRHIAIGDENLPLCSALKSKDIPENMLDKTQSMDVITFEDSKSSEQDSEKLVKTGDKEEFDFKLAKVLRRDEVQSLQQIGQTIERNLPSSTTSDPSLPSIKSDSFGKGAKSPFSNKEEHKAQMDELTVDDAPTDQTEFDESKQKHLSANNFKEFLPMSTSTPFASLSSMHSSARDDELWQTAQSIEREKVRTTLKSDEIESEMDTNILQKKELPVSRRKSTRNHRRHSRSGRFHHGVEKQQIAPLTPSHSKQIPNVNVYIVIGVVKRRESSEKMVKPFPIIFEGKMGEVQWRATFNIKVKDADTPLDFEPTKVLVNENVVWSKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6L6</accession>
    <name>A0A158Q6L6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS3881</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000207">
        <property type="protein sequence ID" value="VDN53908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6L6"/>
    <dbReference type="STRING" id="318479.A0A158Q6L6"/>
    <dbReference type="WBParaSite" id="DME_0001042001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001042001-mRNA-1"/>
        <property type="gene ID" value="DME_0001042001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041044482" description="dolichyl-diphosphooligosaccharide--protein glycotransferase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="117"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN53908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0001042001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31293" checksum="3C27818D07E66D74" modified="2016-06-08" version="1">MVILFLTAAVAFSSRITSVILYESIIHEYDPYFNYRATLHLLDKGHYQFLNWFDSNSWYPLGRNIGSTVYPGSIFANKLFLSLIRLFRINNGTWIVLQMKISVEALILHETTILFTGLMVVAAFLHKFLNWLHITVHIREICVFIGPIFSVFTIGVMYLFGKKIDNDCTGLMSAALMAVVPGSTFRSVAGSFDNESTAIFLMVFTFYCWIQALDSGNIFWSMICALVYFGMSYTWGGYVYVLNLIALHSFFLILAGRFSSKTYVAYSIVNILANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6N4</accession>
    <name>A0A158Q6N4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4045</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000259">
        <property type="protein sequence ID" value="VDN54072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6N4"/>
    <dbReference type="STRING" id="318479.A0A158Q6N4"/>
    <dbReference type="WBParaSite" id="DME_0001062201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062201-mRNA-1"/>
        <property type="gene ID" value="DME_0001062201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="47"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="796" mass="93328" checksum="277CAA361C847515" modified="2016-06-08" version="1">MAEILMPSQISLKKVIFIVDGNVKMTLGLIWTIILRFAIQDINVEELSARDGLLLWCQRKTAPYHNVNVQNFHTSWKDGLAFCALIHRHRPELIDYSKLHKSDPLHNLNLAFDVAEKHLDIPRMLDPEDLVYSQRPDEKSIMTYVSCFYHAFRALRLTSKHAETAANRICRVLKVNQENEKMMEDYESLASDLLAWIRRWMPWLSNRSSGDTLESIRKKLDDFRNYRRLEKPPRIEEKGRLETLFNTLQTKLRLSNRPAFMPKEGHLIKDISAAWRGLEDSEKGFEEWLLSEMMRLERLEHLAEKFRRKCALHEEWTHGKEEALQSSDWRSSGLYKIKALRKRHEAFESDLGAHQDRVEQIAAIARELSNLKYPNIGPINSLCQMICDQWDRLGRLTKQRRKQLEDAEIVAEKLDKLYLDFAKRAAPFNNWLDGAREDLVDIVIVHEMKEVQELLAAHNQFKVTMPNADSEFKNILQIEQEIVHLVEHNGLDRELLRNPYTDLSAIELRRKWQEVQQAIPSRDNQLQREWHRQQNNERLRHLFAEKANAVGPWLEQQLEQVLAIGLGGRGSLENAISQLQSIRQQAHNYKPNLDELERINQEMQENFVFENRATRYSMESLRVGWESLLTSINRTINECENQILMRDCKGITEEQLNEYRASFNHFDKDRRGLDSEQLKSCLISIGYNIRPGREGDQDMHRILSIVDPNKMGRVPFNAFLDFMTRETGDADTSEQMIDSFRTLASGKPYITADELRRELPVEQAEYCIRRMATYRDSHMPAGSYDYASFSRSLYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PBI1</accession>
    <name>A0A3P7PBI1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PBI1"/>
    <dbReference type="STRING" id="318479.A0A3P7PBI1"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="203"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="561"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="922" mass="105597" checksum="9F0C312813E6BB88" modified="2019-02-13" version="1">MDDNRELYVPELNKTIKAHRNFRLFATQNPFANYAGRKRLSRALLNRFVILKFSRLPTDELYSMVHLKCQISESAARLIISVLKDLRARRSYTGMFSMHDGFMTLRDVFKWANRFARSDQIDWRQCLADHGFMVLCARCRTTADENLIKHTIEHYTSRKIIPNQLFAINSRYMPCITEFFEKNVVPTFNMRRMIVLCSQAWIHNEPVLLVGETGCGKTTVAQLLAKFIHIHIKELYIQDSLLSLNCQERTDTCDLLGSIRPGENGTFKWFDGVVVTAMRSGRPVLLDEISLASDSVIYKTFNFVVLINLIVLERLNPLLEPSRSLFLTESGTEVEKIVAEPGFQIISTMNPGGDYGKKELSKALRNRFTEIWCPAVFTAEDVKSIICHRLSRSSLFNDDDGFKFKLSSCMARFLAWYFDHISKIARCGISLRDVVAFVEIFISSMKRDVRSIYWSVYEAFVAIDDGISLNISDHHHSFEKHRFECQEKLKFILMDNLYKEITEEIESPIFNSLIKTDDRGLIIGGYLIEFGAKKPVHLKNFVFNTDWFEKMSLNIARALSIDKPILIQGEPGCGKSSIVVALAAATGHHLTRLNLSEQTELSDLFGTDVPTVLQDGRTSFEWKDGPLLTAINNGHWILLDEMNLASQSILEGLNACFDHRHQLFIPELNRMFEIGSSSHNSKFFACQNPHNLGGNRRALPKSFLNRFSVVSVSFQINDYHDYLSISSQIYGIQSDMNQILNKVNRSVKSKMLKDKTFAKIGGPYEFNIRDVLRWSSFISEFGISNYPYELLYVQRFRTEEDREVMREIYKKESGESCKTLSLSVSVSDKFVRIGRIELIRSFKRIFEDNLKLLPSQASILEHLATCVRMNWISLIVGESKIGKSSVVKNLAALTGNELKIMRLTSETDASELIGSFEQVNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PX97</accession>
    <name>A0A3P7PX97_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PX97"/>
    <dbReference type="STRING" id="318479.A0A3P7PX97"/>
    <dbReference type="OrthoDB" id="10055367at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000637">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="161" mass="17466" checksum="0E2902F9DAE3B499" modified="2019-02-13" version="1">MPENAVQENGDLIIKDVEESNAGQYRCTATGSHQFATDDATLNVAHSSSIVGKPPPLMVDPLVQTVNENEPATFRCWVPGLESCELTWHKEYLGGPLPYGVYQSAGVLKIPRAQLKDAGNYICTASNEFGVGQSPPARLIVNRPFPGIHSNSISLKNFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QDC0</accession>
    <name>A0A3P7QDC0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001229">
        <property type="protein sequence ID" value="VDN60638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QDC0"/>
    <dbReference type="STRING" id="318479.A0A3P7QDC0"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20980" checksum="582EECC93A4EA0D3" modified="2019-02-13" version="1">MHDLLISFQILSLMEHFDLLPFGHEKIGSLSESAKRRLIICTYLLSDPLILLFDDPTKDLDALSNYQLIYSLNCYMKRCHRIALISLRCPRSDIYQLMSRITILFYGEVMYSGQTKYMLSYFRQIGFPCPSNENPAVYYLSLATIDRETSQRYRESQDQAIKLVNLFMVSSERDFRNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QKP9</accession>
    <name>A0A3P7QKP9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QKP9"/>
    <dbReference type="STRING" id="318479.A0A3P7QKP9"/>
    <dbReference type="OrthoDB" id="2126778at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="1">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="445" mass="50724" checksum="5A06CDE8ACD21ADD" modified="2019-02-13" version="1">MNFDRFVEHFDDSTITKVRKQYWTTKQFIRKKLGKKEDEYLLASDAEFDAKISIFRSLRETSEQMLFCVDDYQHYLTELVQSEIALGKMLKNDGEEDKTEAGKVMCVVGRVISLSAHNRLFMRSPLLRFLSELQVFIERAILDCAATVDPDAGIALEKFRIAQSVVRKNKEKLDGLKLDTLQKVDLLAASRCNLFSQLLETYQKFLYRFYEQTTAAYSKIYGLVSGHKHYRFEVLKELMDPVLDSEDNQKLKEDAVNSNSENCSLISIDTKENEIDSILLGLEAMEMEIETFDQRLESPLGQAPDNNLLNSSPIEDKPIVGPLPIKELDAKEIPKIIPPPGWKANRTETNYTNDLMELLSFNNPAQSELDSFALEWSKIATPTTINNSNTHTSSLNMGNLPSQLLDTQNFQSQNFPNPFTDSNFSAWNGLILEFESSENNSGRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QMX7</accession>
    <name>A0A3P7QMX7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QMX7"/>
    <dbReference type="STRING" id="318479.A0A3P7QMX7"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="131"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="521" mass="58676" checksum="F8434778D317E772" modified="2019-02-13" version="1">MVASNLKDGKIVPRLNDAVRTMSDVVRHGRQLSKDGLMCGYRRAKPDGTAPYVWLTYDEVFQIYKLGIMSGQKTFIGILAKNRPEWIIWEQATYNNNNIIVPLYETLGRDACIYIINETELEVVILDNETKFPTEDDIATIAYTSGTTGSPKGVVLSHGNIIQTSEIIDRLQDVLISFLPLAHMFERLVETLFFMFGLKVGYYSGDVKNLIEDIKELKPTVVPLVPRVLNRIYKMWLVVKRLGVMRATLLDEIVFKKIRQGLGGRIRLMVTGSAPVAPEVLEFSRAVIGCLVLEGYGQTECVAECTLCIEADCSTGNVGIPVPCNMIKLVDVPELGYFTGEICVKGFNVFKGYYKNKQLTKETIDEDGWLHTGDIGKWTTQGTLRIIDRKKHIFKLSQGEYIAPEKIEAIYVRAKYVAQIFVYGESLKTCIIAIVVPELMELAAELNIKETSFEKLCKKSDIKAAILNEMTNMGKLVKDIYLSSTLFSIENDQLTPTLKNKRNKLKQHFSSELAKMYAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QT80</accession>
    <name>A0A3P7QT80_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QT80"/>
    <dbReference type="STRING" id="318479.A0A3P7QT80"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="133" mass="14582" checksum="C845DA17CD3B1262" modified="2019-02-13" version="1">MESYNEKADYCPACIRKNPGNKLNDSLNDAKNFSSRGAYKKFQEEINSSVDCMQTIASYIVNGLYEVEKKEGNGKGSSGFDNQNKPDLSPSFNQLPNIVNSSLTPTNIPPIGSNLNPFSDDENPSSTNPFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QW24</accession>
    <name>A0A3P7QW24_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QW24"/>
    <dbReference type="STRING" id="318479.A0A3P7QW24"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF100">
        <property type="entry name" value="CALUMENIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="284" mass="33179" checksum="9D610DD284704CA3" modified="2019-02-13" version="1">MAGEHDSKYDHEAFLGKQSAAEFDELTPELSKERLAKFFPKMDLNGDGFVEENELKEHINFMQRRYVDNDVERTWKNYNQEKVKDGQLSWGDYREMVYGSSDGEGQELSPEYAKMISRDERRWKKADYDSNGVLDRTEYGCFMHPEDCDHMRDIVVQETVEDIDKNKDGFVDMDEYIGDMYRPEDYPELNGKEPEWVASERVMFKEQRDKDGDGKLNEEEMRDWIMPVGFDHADAEAKHLVGMADDDKDGKLSIEEIIAHYDTFVGSQATDYGEQLQKHDPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SC45</accession>
    <name>A0A3P7SC45_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SC45"/>
    <dbReference type="STRING" id="318479.A0A3P7SC45"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="165" mass="19250" checksum="67464550692CE234" modified="2019-02-13" version="1">MDSLTPYCGIRWTIAVAFIILLIWRIISVQGFYIIAYATAIYYLNLFLAFLTPKIDPALDFDSEDDGPTLPSKGNEEFRPFMRRLPEFKFWYSTVKATVIALILTFFEVFDVPVFWPILVMYFIILTCLTMKRQIMHMIKYRYIPFTTGKPKMRGKEDSGVVVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SLM8</accession>
    <name>A0A3P7SLM8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SLM8"/>
    <dbReference type="STRING" id="318479.A0A3P7SLM8"/>
    <dbReference type="OrthoDB" id="202764at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="537" mass="60237" checksum="064360D838CA6E16" modified="2019-02-13" version="1">MELDDDDLECTGMTASHDQLRLYQSVDSTHPKKSAIALPPPSPHSAPPIGAGFRSDIDSTTFMPIPCTSHKMVPTRSNTTFTVLARQNNTIQDPASVLSRPTDLELKTHNSNIYNFELLHIFQSAVNDMRLQQSLSTPCPSGGDETAISRKEAEYRRFKSEGSAGASCSLPAPEMDVAIDDFSPIADSRSSPPNRLNLFQDTVTNGPLTKHSHTEQVMMMHTLKTKLSKYQNFIDKAFEHIAQGSDEQIIEGCTIVAKVMTKAWMFPKISHDLSYSLCDYLRDQAYFDTLIIIFIKAQTCESVRLACGRVLEECLSSKNRDYIVNKGYLKKLVATAEKLSKNPEQQRMSLSIMESLFKHSTATTYRLIEYGVLDHILLTCKRATDTPITLRHAALALANLSLYSCSEAKKKIIQKKVPDWLFLLASQPDDLTRYYACLAICMLGSTKEMETAVNKSGTLALVEPFLLAHPATSFAGDHYKHSQGRPKEWLVRLLPMLKSKCREAKSMAAFHFKMEATIKKDQQNLEVFQVKKFFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SRV3</accession>
    <name>A0A3P7SRV3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SRV3"/>
    <dbReference type="STRING" id="318479.A0A3P7SRV3"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="1">
        <location>
            <begin position="12"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="339" mass="37900" checksum="6828101B14780E5D" modified="2019-02-13" version="1">MESSETGEVKLCVSYQVTCCGWYPIYDIRVRSDILWSIDEILLTYRGCVYQNCDEDWVNASLKLSTAQPCLSGIMPELGSLQAIFHKPTPPPSVQPTHPFAMKCTHFGSTTPLNTGVSESVMSTIFDVPTRKTIFSGSGEHKITFALLDFDSVMVHQTIPNKNTNVYLVASAINDSPYPLLSGSASVYFDNSFIAQTRIKSVSPGERFQCSLGVDPAVKVEYKPAYKYSEQAGLISKSSLTFHEQKIIIKNTKKDKILLMLTEYVPKSTDERIKLISPELDVVEDKNMVGKILSVGRRINADNNLEWTLSIAGKAEANLLVKWSIDYPSTETIEYKEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0S3</accession>
    <name>A0A0N4U0S3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS4524</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion inner membrane</location>
            <topology evidence="2 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0S3"/>
    <dbReference type="STRING" id="318479.A0A0N4U0S3"/>
    <dbReference type="WBParaSite" id="DME_0000016401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000016401-mRNA-1"/>
        <property type="gene ID" value="DME_0000016401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="97"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN54551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000016401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35442" checksum="2ACABAB81CD31B99" modified="2015-12-09" version="1">MNRFNASEEEKRNQRMRRNTKLGVIFGAGSIILGFTWFCIHYGKSPRDENGLATRDEFSGSLLAPFRRIRKHFHLWMDYVIEPSREVLLPSPIAPPYYQPKYTLVMELKNILVAPDWSYTSGYRFIKRPALDYFLTMIKYPNFEVVLYTSESAMSAHQLVESLDPDHCIMYKLYRDCTKYMNGHHVKVLSQLNRDMSKVIFIDHDPKSFQLNPENVLRIPKWEGNMDDTSLVDLAELLKTIHLSDVDDVRPTLQYYSQFDDPAKEFRRRAVELAEKVQHTSNDSLLKRYTGKLFGFRRHAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0S4</accession>
    <name>A0A0N4U0S4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4525</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0S4"/>
    <dbReference type="STRING" id="318479.A0A0N4U0S4"/>
    <dbReference type="WBParaSite" id="DME_0000016501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000016501-mRNA-1"/>
        <property type="gene ID" value="DME_0000016501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000016501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16592" checksum="8891E3C77079FBE0" modified="2015-12-09" version="1">MQFYIYILQSATPKELNSYDAELNSTACSKVCTADENCEEAYKFEETLNDKEKLQLTIENEQLFNKLAQVDGNMQRIEKQMADIQQKDIDLINDATIRASENVLEGNKQIREAIQNIASRRIIILFCIIVLTFTLLFLDWYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0V6</accession>
    <name>A0A0N4U0V6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4562</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0V6"/>
    <dbReference type="STRING" id="318479.A0A0N4U0V6"/>
    <dbReference type="WBParaSite" id="DME_0000020201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000020201-mRNA-1"/>
        <property type="gene ID" value="DME_0000020201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="68"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000020201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43936" checksum="280094404785595A" modified="2015-12-09" version="1">MQRFIIRLVTAEKKLVNAAASLPTWQYSTNVFHSQTFSFKRFDYFFLQADPLAKYKILAENTIEKPTILITGAMGQLGRGIASILKFMYGTESCLMTDVVKGSNDNNCSPYAYLDVLDKSAIEEMVVNHNINTIIHYSAILSAVGETNVPLALKVNGEGMQNVLEVAKKYNLKIFIPSTIGAFGPATPKQNTPNICVQRPRTIYGVTKVYGELLGEYYNERFGTDFRSLRFPGIISATEPGGGTTDYAVKIFYDAIQYGKYKCYLRPETRLPMMYDTDCTASVILYLLASPDKLTQRTYNVTGFSFTPEEIAASIRRIIPNFKIEYEVCPIRQKIADSWPDSLDDSMARKDWGWKPEYDLERTVNIMFTLIERQIREQQNNPKKANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U108</accession>
    <name>A0A0N4U108_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4619</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U108"/>
    <dbReference type="STRING" id="318479.A0A0N4U108"/>
    <dbReference type="WBParaSite" id="DME_0000025901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000025901-mRNA-1"/>
        <property type="gene ID" value="DME_0000025901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000002">
        <property type="entry name" value="Signal-induced proliferation-associated 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF22">
        <property type="entry name" value="RAP-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="5">
        <location>
            <begin position="277"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="637"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000025901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="788" mass="88645" checksum="C6AED89AA03232C6" modified="2015-12-09" version="1">MTFQVSADQHSSYYESESSTQNSVFSDWRPTHPRLCAFHDCVSLASAWGLGPPTTSLEPRPTGASQAHSPSEDDNGDGKSNDLLSSCPAFRNELGDEPIRYVALTRSAVETSHHLSIINIPEHETWLCEQTAAEAGILEDVSNVYLGGRLCAARQPKIVIEPQDIGSYYYRHCFVGRQHHNFFGVDENYGPIAVSMVRETAERVEDGVIQPLSIYRMIIRISDLRIFRVAVPEEVVTDGVEQKSIRALMRDLLEIVCPQIQFSCLRPATSNRIEELLTKIDEQPIYTRYKVGVMYCGEGQSTEEEMYNNEHGSPLFEEFLDFLGQRIRLKCFDQYKGGLDVRGDTTGTHSIYAEYQAHEIMFHVSTMLPFTPSNKQQLARKRHIGNDMVTIIFQEPGAQPFTPITVRSHFQHVFIIVRANPRNSGEDATYTVAVSRAKDVPSFGPPIPRGATFQKCTEFHDFLLTKIINAENAVHRSKKFATMAARARREALKELAENFVAAHPNEGPSRIASRFLGGSMKRKERIQPKPQLGECLRGALSWLVDVHEYTMNQRITCILGVSAETLVLLEIPTGIVIFTTSTHSIIGWANTDMGLKIYYDHGQMLLLRCCTTDGSDTELTTLLRRLECVTKGVEAKEIVHHKGKKTNDLGFHLQEEGVVTDVEMYQTAWKSGLRQGSRLVEIEGKPVITLCYEEICEILANNITLRLVMIPPALDGSPRRGCEDPNCPAIKGDGNIMLTPDTFAKQPVRCVNCVIIKYSNIAEWYSTNKRIDYLLVALKPKQLINDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U168</accession>
    <name>A0A0N4U168_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4692</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U168"/>
    <dbReference type="WBParaSite" id="DME_0000033201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000033201-mRNA-1"/>
        <property type="gene ID" value="DME_0000033201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6502958at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000033201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29583" checksum="6132E32F088CEF97" modified="2015-12-09" version="1">MFNHLVVENMSFMGKLALAIDEVFSLRSHIELQYVASAKSTKSLPLTWQTLKDKANSIWAEICDHDPDLKNRNFVANMGWIARFIKRNNIQLVTLPNAPPASSPIGISRQPLGLAESSLQPKSSQSSKCDCTKEHFKISHSSFMDGKSSSCDFYLKLGPALSFSAKISPISGKNVQSPFHCTEDCIAQNRNVDPQSSFPNNSSDSQNSVESKCKVLEQCQPSASKSRRKNFIPRKLVFDTSTLANPCDDLTDVDIYTGINDSLMIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2D8</accession>
    <name>A0A0N4U2D8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5196</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2D8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2D8"/>
    <dbReference type="WBParaSite" id="DME_0000083601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000083601-mRNA-1"/>
        <property type="gene ID" value="DME_0000083601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978002at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007144">
        <property type="term" value="P:female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027963">
        <property type="entry name" value="MEIOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33861:SF5">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33861">
        <property type="entry name" value="PROTEIN CBG18333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15189">
        <property type="entry name" value="MEIOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000083601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30094" checksum="8F2C05CA13A21BEC" modified="2015-12-09" version="1">MKSDEQRLIDWNSSMNNNRPNMNEKRISPLVSNNNAWLPAFSAQHQRQQQRQQEQQQHKRCPSTSRDLSLFNELYINLEACTEQYRQLEKERKKTEAELARHNLGKKISSTNNIPIPRIAPLPTRIDRLIVDFFREHARIVTLLMKMEQLRNAPLPPDVHGALQGFFDSIKRLQSERENEKNLIKKIFSGEMSLRIDEIRELSSALEKVNENVVRARSANWCSLMWTIGADDVSESYIQRIVSANFNLAPPEIKHRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2W5</accession>
    <name>A0A0N4U2W5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">POT1PC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5405</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2W5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2W5"/>
    <dbReference type="WBParaSite" id="DME_0000104501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000104501-mRNA-1"/>
        <property type="gene ID" value="DME_0000104501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5853097at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="8">
        <location>
            <begin position="148"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000104501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52145" checksum="6DC302712CA1E5CC" modified="2015-12-09" version="1">MGLRPDDFIKCTLFTDISDSIVNYIKEGNIIRLHRIEVRNKLDGSCVGNEPCFLQGRLNSFGLSALIYGEKSGDGYKVLYSSSNNYTTDKNYQKIVENLYASWEAYKNKMHKEIDQENLNECRIRGRSNFVVDQLPAGVLMHLARFEQFKRFSYHNIVVQVISIFISDRGNVVLRCWDTTKIHGKPFQFTGESISKIIFTDEALEKLSEGRNYDVILYGEYGTLAIQILLSGDVIVMKNLHYYISSMSSSLVIHDGRGNFDRGFSVLSDHSEFKKSIVNAVENIIKNQLNTNEGPSEISTESHEVIESHEVSESHEITISETQEPFPTISKLLITANEGSHEFRHRLIELFQFHAIIFAINTFDYFSNNSVNQIISTRIRYLVRLLLKRFYKFIYSDGEQQCLVLKCFFPFSSKKFFDVRLPQNPAEAAMLWKRGIDSRQKSAKSEEIKVLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2W7</accession>
    <name>A0A0N4U2W7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5407</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0389 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2W7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2W7"/>
    <dbReference type="WBParaSite" id="DME_0000104701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000104701-mRNA-1"/>
        <property type="gene ID" value="DME_0000104701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8193498at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009432">
        <property type="entry name" value="DUF1075"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06388">
        <property type="entry name" value="DUF1075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000104701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46097" checksum="DEA29D5537422BE5" modified="2016-06-08" version="2">MSSSDERVVEGIVWDRVEGRGIVWDRVEGRGIVWDHVGERGIVSDRFEGRGIVWDHVGERGIVSDRFEGRGIISGRVEGRGIVWDRVEGRGIISGRVEGRGIVSDRFEGRGIISGCVEGRGIVWDRVEGRGIVSDRFEGRGIISGRVEGRGIVWDRVEGRGIISGRVEGRGIVWDRVEGRGIVSDRFEGRGIVSGRVERRGIVWDRVGGRGIVWDRVEGGGIVSDRFEGRGIVWDHVGERGIVSDRFEGRGIVSDRFEGRGIVSDPMHALNQLIVRSRFPSHYHLSKLLLSIDNNRQEQIVPPQSNQIPQHITKQQMQYRKSEKNAQNDLGNGIKPTKWQRRALILTFLYSNDKAIPEYVPKTVMRSLRNRLRVTFIMMGIFWFYVITFAMERSMVASIFPNKASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U381</accession>
    <name>A0A0N4U381_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5536</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U381"/>
    <dbReference type="WBParaSite" id="DME_0000117601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000117601-mRNA-1"/>
        <property type="gene ID" value="DME_0000117601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000117601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10339" checksum="1C35C01332EABDD4" modified="2015-12-09" version="1">MEHPNFNPVLPDSPQQSPSPQDFEIWRGFKGAELGSMVLPSERNEVVKIGVMVITIVLELSTSSWRTLRIPQDYPSIHRSSMFLTQKLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3U4</accession>
    <name>A0A0N4U3U4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SERTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5769</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3U4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3U4"/>
    <dbReference type="WBParaSite" id="DME_0000140901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140901-mRNA-1"/>
        <property type="gene ID" value="DME_0000140901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875701at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28493" checksum="3BEA858C7E7D9607" modified="2015-12-09" version="1">MELNEENTSADSRSSSVFDEVITKNSEENVSLSPKSEKYRIKKFYLQKKCDDIQKVSARLLNRIYRIRKEISYLRAQKRMLCQQLTTIMDNYSELSLDIPESEPCLTGMELFSDEASLSILIPKKRKFAEAKLSAASDFSTMEENARKSIISIIDSVITESHEERMRAEASNDVHMGNSNNPSTENFNVESSTNAKNDNCVTDVDGQSMVDRMLRASSIDHLLPIEPENCRSDNKLTVSSNYSNNNTFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4U4</accession>
    <name>A0A0N4U4U4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6186</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4U4"/>
    <dbReference type="WBParaSite" id="DME_0000182601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000182601-mRNA-1"/>
        <property type="gene ID" value="DME_0000182601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5785512at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF7">
        <property type="entry name" value="PROTEIN CBG04538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000182601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23971" checksum="03B80543D0A51BAA" modified="2015-12-09" version="1">MLKTEKNVFIMRCTMMDGGSWKTEVTACVTPSGIRIPINETHKDERSQWTCSITPDGKITMQHGVNPDAKCDGHDVGSKWIEKSFEFECMPGGNPKLLACVGENSQKIPVGTTKEIDGYQMNCQQFDNGTIILHGTRKSFKHEKGNAQTECVDAHGNHHPAGSTWLENERFNKICTESGRIDIESCVTQTGQKVPINGELIEGDTKYVYVNLKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U599</accession>
    <name>A0A0N4U599_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/ethanolamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6372</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U599"/>
    <dbReference type="STRING" id="318479.A0A0N4U599"/>
    <dbReference type="WBParaSite" id="DME_0000201201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000201201-mRNA-1"/>
        <property type="gene ID" value="DME_0000201201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3649325at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN56399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000201201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="46241" checksum="7EC08EDD7931CC8B" modified="2015-12-09" version="1">MADHNRQLIEIFSRPLPDDELAETTRKLCSVYLNGVWQTISAKQMDIKLQSGGLNNSLFVVKLAPNVKRIGDEPQTVILRIYRNVTCEGELIQTAISLALAERSLGPALLGVFPGGRIDEFIPSRIVTNKEFLNINVAQRLARIIANIHSLELPISKKPILVDIIQKMLDELKKSFRWISKQKMPATIVKPEVRILKEGNVLLRQNFQITEESLNGAQDGVDPLILIDYDYGSYFYRHVFAYFNSFEFYSKHFAGFDIAHYCMECCLHNENPEYPYYSILPEQWPEKEHRRKYIEAYLDEATKIMKKRDGKKPWNISDLPENRETAVEKLMTEINQFVAIANLFWSIWSFYMAESSGKSEYPFFKYGFERIALYYYWKPEMLKYVAINPYVDNYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5B7</accession>
    <name>A0A0N4U5B7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6393</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5B7"/>
    <dbReference type="STRING" id="318479.A0A0N4U5B7"/>
    <dbReference type="WBParaSite" id="DME_0000203301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000203301-mRNA-1"/>
        <property type="gene ID" value="DME_0000203301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF9">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720845" evidence="1">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000203301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22569" checksum="A9B8F334EB2B54A1" modified="2015-12-09" version="1">MLGFYVIIFSFLITIADGCFTSGVCQHCIPMPQPSCSTGCSTGYSCGHYGCYSRARARSSKTLKKIGSFEDEDEKSLVTELQNPNEKFFNCCVERNLPDACLQKCSFNTYSRNALQAMFFRSDPCPMQAASDIHFCAAQGQDHRQCCLSNGVAATIAGAKCLTFCDQRPDHITQLDISYLPCYDRFENIKGCFWEYLNQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6L8</accession>
    <name>A0A0N4U6L8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6936</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6L8"/>
    <dbReference type="WBParaSite" id="DME_0000257601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000257601-mRNA-1"/>
        <property type="gene ID" value="DME_0000257601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5782184at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056655">
        <property type="entry name" value="DUF7753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24936">
        <property type="entry name" value="DUF7753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720358" description="DUF7753 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7753" evidence="2">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="41296" checksum="3929682B67CB62EB" modified="2015-12-09" version="1">MFLSGRSFLASTLRCFLLFSLIMVKIFCQYDCDVFDPNCYAFYRLNLNNYHRSDQPKSNRCNQQSVWLIPGRADATCTRPEAKRIFEVNPHEVKIHPEVIRLPGCFTIEINNIKILENDGTIPNSFFGKVEYQWMNIKDFSELKCQNASNNGCGGYGNNCYYCDICDGLNELDNAQNQSPFINELKGLSCPNHPGLYTFRKEFCFNDWSMFDKNGDCQLDFLQGERSSDYKSAFASLQQVGYGTIVARLRLAYNATKEIAQKRALKEKQIEEMITRELEEKRRTWDVTNGEFQRFQKWYINYRKNLWHKEDYLPWLLYENEITCIRITFDVCERLPSRSKYGKLRYMCDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8A4</accession>
    <name>A0A0N4U8A4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysosomal acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7421</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8A4"/>
    <dbReference type="STRING" id="318479.A0A0N4U8A4"/>
    <dbReference type="WBParaSite" id="DME_0000326201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000326201-mRNA-1"/>
        <property type="gene ID" value="DME_0000326201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF34">
        <property type="entry name" value="INTESTINAL ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039884" evidence="4">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000326201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="40475" checksum="3F9CAA12FD5C1C5C" modified="2015-12-09" version="1">MHRIELIVLIYYLINYATSNDELIYVQAVFRHGHRAPHQLPYPNDIYNETYWHYGWSQLTNLGIRQLYDLGKFFKWRYGEFIPEFDVKKVHVVSTDTDRTIASGEAMLFGFFPTTNESTWLEGETWRPIPIYTAPQGAPSSVKLMKAKFFQYFLIFFIFFMYFNIFFYIRKYTTVIFFRIIHAFYILIYFLLIFQIHNLMNKHFGFKSGKMMIFQILHNLTQPEWIYQKWASHDNLTTLQIIEEMLKTQLSTEFNSEIKIKLNGGLMLADWLQRALRVSNGTNYKPEKMMIYSAHHRTVLALQYAFGVNDSGMVTYGACFIMEVYRSIDGIRIKVIFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U920</accession>
    <name>A0A0N4U920_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7567</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A0N4U920"/>
    <dbReference type="WBParaSite" id="DME_0000356201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000356201-mRNA-1"/>
        <property type="gene ID" value="DME_0000356201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="225"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="322"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="660"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="754"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="910"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1137"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1230"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1322"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1527"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1843"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1951"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2056"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2170"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2281"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2397"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2619"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2749"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2847"/>
            <end position="2936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000356201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2975" mass="331563" checksum="55964148F4001028" modified="2016-06-08" version="2">ADAGEFRCEAQNPYGSARTEAALIVRYAFEEPFETEIAPEFLQEIKAAQVNELQEAIFECRVSGMPLPKIKWYKDGEQMKADDNVKIESFLDGTNRLIIKSVNLNDQGNYRCEAINSIGSMSSKAPLTVNTLETLKLVKGLEDLSITVDMKVELTVEVEGQPKDVKWFKGKDEIISDRRIKMKKISAQQYSLEILNSQPSDSGEYRVVLCTETESVESSSAVTINEISKLVCRKGLNDKTVRKGEKLVLEIEVDGKPKNIKWYKDGSLISAKAENLGNGEYQLSIPEINESHAGQYSAVVSDEFGTITSSAKVTHFSVEEKPEIINGLQPITVKVGDEIVLEVKTKGDIKSVKWYKNGNEMKDVTTNYDGNKHQMVIARASIADDAEYKIVLSNNSGDAESAAKLTVKQASPQLEILNGLVDIAAIEGEKVLFEITASYTPDEVQWFKNGELLSPSEIMPMAVSGTTCSLTIPRVSSNDIADYKVILPYSLSCFIDAQFLYFERYKNGREIEPSDKAKQVKIDDQNYQLEIPEVDIEDIAEYKVVLSNEIGEIESSAKLSVKEFSPSLEILKKLNDISVGEGVPVELQIEASCRPDVVKWYKDRDEITSSDDIKLEAISETIFKLTIPKTTGDYTANYKVVISKQGESAFSQCSLIVKVPAIAITKGLKDQTTAPGEKACLQIELNTIPRQIKWYKNGKEIGLNDKAQPKKISDKIYELQIEDTTKDDTADYKVVVSNERGLADSSCSLIVKLPDLRFTQPLRDQAITEHDTVQLIFEVNTSPESVKWYKNDKEISPNDKAKSKKMEDCKFQLEIPDAKKEDTANYKVIVSNDNSNAVSSCALTVKLPALKIIKGLDNQNINVGEKALFSVETNGAPQIVKWYKNGKEIGLSDKAKAKKVNDSNYQLEIPDATIDDSADYKVILSDNGNFVDSTCALTVRLPPQKPTFIKGIEDQFIPVDASREIIIKTTGSPKTVKWYKNGQLLINEINKPMKIQMIDDNNYILTFEKVTLNDSGSYTVEIENEAGKAKSSGEITVEPHLAFLHPLKDMEVIEGEKAEFTLEANAHPRVVKWYKNGREIKDAAGVLEIKDNYTKFSLIIAKTNKGDAADYKIVLSNSIGDIESSAKLLVKKSKGQPKILKGLEDQVILKGDDLILEIKIDGEPTEIRWLKNDSPLSKNVAVTIEKLDEQTYRLVIPRANVTDAGSYSVEAVNEIGKARTSANIGVDEKPEIVKGLEDCQIDEGDEQIFRVETNTPIRAVKWYKNDQEINLSHKVTMKKINPKKFEMSIGKASLDDGAIYKVILSNSAGECGSSASLTVVKPNILRILSPLKDTDVNEGEPIKLLVKIEGQPREVKWLKNGKDITSDDRITIEEKNDLGEYWLAVPCSVHSDGAAYRIVLSNDRNEVQSGCIAHVKAKRLEPATSTPTIVSPLIDVELPEGETLTLKCKVAGEPKPEVKWLKDGKELIKNDHTVIRMALDGTAMLRILDTTKINEGRYCVTAYNSVGESSSSCNVHVLSDDELPSAPRFIIPLKDVFTQAGLKVELGVKVKGIPKPNLDWFINDVRIIFDDEIRFDDIGDGNWTLIINSARIDQTGRIRCVATNKNGKAECDSFFTVTEVRPSRIKADEGYPPRFNVPLWDRRIPDGQLMIIECHVDAKPLADIQWNKDGILLQESEKISINNTSDGACRLRIYAFSQSDIGLYTCIATNALGSADTCANLNIQVEEINEVKSKLQFAPRFNPPLVDKYSEPGEKIYLSCRVEAEPKPSVTWFKDGLPLRNDGRTLVEVDEVGNCLLTILSANESDSGAYRCVAANELGSTNTACTVNVKKYKEAIKKEGEKPFFTKGIVDKWADKGETLKLTCAVVGDPTPDIRWYRNGTLIRTSGRYKLENLYDGTCSLTVVDSKMTDEGIYRCEAENIYGKANTQSTIHVEVPIAKIEPKKIGQGEAPRFVVPLEDLSTLIDSSIELECRVTGDPMPTVKWSKDGAVMLDDPRYVWETDASAGFYKLKIDFAQICDEGTYRCVASNETGSATSKAFVRIDDGKDLSKSPEIYPPFFTISIGDIRVVEGQPLKLECKVEGLPLKSLIWYKDGERILPSDHVHMEMDGEGRARLIIPHCAVEDEGLYRVIATNAIGSAHDKGTAIVKRLPKDHEEYLLNGHQFDLYRAPKVIIPLESCKIPEEGHLALRCKFSGDPRPSIKWFKDGERLYAYGRCQLNESDDGSCELVINNISRFDAGNYRCVAENIYGSARTINEVVVQMKERKPLKDFEEEMREGNAPGFSIPLTVKRVKVGADVVLECLPYGKPFPNITWLKDGIEIDFSDRIKAESTADGIQKLILNDVDFSSEGFYRCVATNEYGTASTKGELNIDDGLGDRSLLMKRVEPVDLEPKESKPRIRPGLYNISAHHGTTIEMQVCVIGWPVPIVKWFKNDEEIKSDGPDGRRLIWEDDRGIHHCIILNCISEDEGDYSVEATNKLGIARSEGGITVIRPREVQLYDEDRSGYPYPPGFIRQLKNKHTFSHMPAIFDCLVVGNPPPQSCGGGSHALIILDTKPEDVGQYMAVARNAYGTAKSSALLDVTIPHLDEIKFNGTTDVTPYLIEEYGFKKQRYAGIPTPPDRGPFIKEVNGHYLTLSWIPTKRTPPRYPQVTYIVEIRELPFKEWVLLDYNIPEPVCKVRNLELGKSYQFRVRAENIYGISDPSPASPPSRLMAPPQPVLDQYKRVIPLLDPYAEKALGEAYAEQYACAPWFAPGVNARKYCAENELLTINLFVSGYPDPNIMWKFRGIDIDASSISSRSHVVTHGGMETTLTVSGFNKEDVGQYQCIATNQYGEAQQSIFVDIGTRPIFLQPLVNKIVTSGKTLRLDVRVGGNPSPELKWMKDWRPIVESSRISFGEEAPYFRSLIITDLMWRDCGIYSAVAINSAGTATTTCSVTVEADGNFNDIQPTEKKLLETKKIKEIYEIDEDDEKNVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9L5</accession>
    <name>A0A0N4U9L5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">VPS26 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7792</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9L5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9L5"/>
    <dbReference type="WBParaSite" id="DME_0000378701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000378701-mRNA-1"/>
        <property type="gene ID" value="DME_0000378701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000378701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35934" checksum="B541204A31ED5175" modified="2016-06-08" version="2">MTAHIRGEDGAKEMHYLFYDGESVSGNVTISTKKKLEHQGVRIEFIGQIEVYYDRGNQYDFIAIVKELARPGEIINSANFHFDFQQVEKPYESYVGTNVKLRYFLRLVVVRRLTDIIREMDLIVHTLSSYPDTNSSIKMEVGIEDCLHIEFEYNRSKYHLKDVIVGKIYFLLVRIKIKYMEIAIIKRETVGLAPNIFNENETLTKFEIMDGAPVRGESIPIRLFLAGYELTPTMRDICKKFSVRYYLNLVLVDEEDRRYFKQQEIILWRKADRINRRIVLDEEMIKSNEVVTTDTFGKVTDARIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9S9</accession>
    <name>A0A0N4U9S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MOB kinase activator-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7866</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9S9"/>
    <dbReference type="STRING" id="318479.A0A0N4U9S9"/>
    <dbReference type="WBParaSite" id="DME_0000386101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000386101-mRNA-1"/>
        <property type="gene ID" value="DME_0000386101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000386101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26107" checksum="A485E3DEA2C67B01" modified="2015-12-09" version="1">MSELAKDMKISKGNSSSLENNASYKQRRKFFEMKQSQLLHYSSATLGSGNLREAVKLPKSEDPNEWIAVNILDFFNQISMLFGTISEHCTAESCPKMCAGSKYEYSWTDGRKTIACPAPTYIDYLLTWVHDQLDDESVFSTQIGVPFPPNFMQIAQTIMKRLFRIYGHIYYQHIETIEHLNAIEHLNTSFKHFMLFVHEFKLIESKDLAPLQEIVDRLAPAREIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9V4</accession>
    <name>A0A0N4U9V4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7897</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9V4"/>
    <dbReference type="STRING" id="318479.A0A0N4U9V4"/>
    <dbReference type="WBParaSite" id="DME_0000389201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000389201-mRNA-1"/>
        <property type="gene ID" value="DME_0000389201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="168"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000389201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53350" checksum="280B4C5B3551D028" modified="2015-12-09" version="1">MDTKQFDDDNGNGNTQLTQKDSQFSQILEFRNVQCEQIEKKRYATLLAMDKGMNSIALYTEYFGFGRKSAYEYYCDFHELSGSKELWLAISSQHCYIQRDFAEKKTYLYDTSKFGTYINTVKIGSGNQRQLISGDLISIVDPKFFVFMYLEGSQEFGDYPSELTERYFVSNHLIGEGAMGKVFIGKCRKRASLAVAIKMIPKKRISFVADRSESGLGPSTELIKREVEIMLSVSHPNCIQLEYVCESPKMAYIVMEYVEGGELFSRITNECNNGRGLGETISKFYAWQMLQAVQYLHAHNIVHRDIKPENILLLKKNIFTVVKLSDFGLSKAGDNSMETFCGTQSYMAPELWSDARHYCSKVDIWALGAILFTCLCGYPPFSTDYTDFSLKEQIMKGRLIFCQVWKKISVQAQYLVRCMLRVDPSRRLAATDVLANDWFNDPVVIKAKSIVSSYLDERKSLTNDGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9W4</accession>
    <name>A0A0N4U9W4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7909</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9W4"/>
    <dbReference type="STRING" id="318479.A0A0N4U9W4"/>
    <dbReference type="WBParaSite" id="DME_0000390401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000390401-mRNA-1"/>
        <property type="gene ID" value="DME_0000390401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000208">
        <property type="entry name" value="RNA-binding protein 27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14605">
        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="470"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000390401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="864" mass="97716" checksum="DEAD1CC79DD004CB" modified="2015-12-09" version="1">MIIESPDALRIWLTKEMAPICDAEPAALAKYVLALLRKDKSENELIEFCIEQLDVFLRTKAKPFVEKLFAVIRDRTYILDSQGNVMGNSQRSGSVKTEKKETDEKKERKDEDKRKMNILLEKQKEKERPKSRERESEKKSPESDSTVHKPPVQKAVRKRISPPQSTPRDEIRRGFFSFSYRNERRRSRSPRDRRVDRPDRGQDRRIGLQTARIVHRQADRHKMDRGDRIERKRSRSPFDRQRQIFNNLRDKSIESERKKRRCRDYDEKGYCMKGDQCIYDHGPDPVVVDDIALEKMVGSGKGATNVPQITHNFSIPPPGYTPLNPPPPGVDNVYVANSNALHPVGLSEGYNPEAPALSAASIAAVPPTVQAPSIDFSVPPPPFPSHVPPAVSWQQNTYTVPSVSTSVLVQPTNLSYDPTHPSTTITPLPVARPNSSMHSNDQSRHRVVSGRGGQTRYNLRGTTFNSTNNRTLQVRKIPASMNNIAKLNEHFAQFGQIVNIQVCYDGDQEAALITYATRLEAMAAYKSTAPILNNRFIKVFWHTVEDQSSAINKETLARSSDSELVNYKGSAKNVHAPPPKIQERTNIASLKPFDSSKTSLSYTNPSIVDKEKYVEVRRKRKLEKENKMRLLDLQRRKSDLLTKEIEQQKLIVQKMQQCTDPEKKKQLYQIFKKVDESVKVLKSDIEGLTVKLLSMSDSCLNSFSDIGIESNDDSANRLQKRARCNVDGIGNPVDVANPYKKGRPYNSTQALDNRPRVVAVSGFTAENENDVIVHMENFGELIDMDFAASAHGKPVTAYFTYKKRRDAEKAVALGSDFPVCPLVVGWVPKDIDQNNVVPDEKRHPAEQVTPAALLASCPLEEVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA32</accession>
    <name>A0A0N4UA32_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chimerin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7985</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN58012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA32"/>
    <dbReference type="STRING" id="318479.A0A0N4UA32"/>
    <dbReference type="WBParaSite" id="DME_0000398001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000398001-mRNA-1"/>
        <property type="gene ID" value="DME_0000398001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20806">
        <property type="entry name" value="C1_CHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10352">
        <property type="entry name" value="SH2_a2chimerin_b2chimerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000019">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000025">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035840">
        <property type="entry name" value="Chimaerin_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="221"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000398001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="47053" checksum="1A06325D78FA3B7F" modified="2015-12-09" version="1">MEDDSGYWKQNLYLLQEAAPRPFAVKCCSLLESKPPQYGMEFHGLIEREFAEQMLREAGDGAYLVRASRRSQGAATLCMVFDRHVLNYKLYYDGTHYVGEKRFETLEDLVADGLITMHMEKYANDYIQRMADEAIYEQSPYSQYQKATDVRKVPIARCHNFSPATFRMPHYCDYCRNFMWGLVQQGVKCEDCGFCAHKKCSERTLHDCRPEAKYIKRMFAVDISTLCMAHSVTIPPVVSACIFEVERRGIRIEGIYRVSGSHEQMERLRRQFDTLHKVDLSSVEDIHTVAGLLKLYLRLLPQQLVPFSVYRLLLGAFSNSRTFHERQKACRKALMELNDANGRTLFALLIHIQKISDYSAENKMSIENLATIFSPTVFCTGAVPALPQQQHHLLHFLIQNPRVVPFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAF5</accession>
    <name>A0A0N4UAF5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8011</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAF5"/>
    <dbReference type="WBParaSite" id="DME_0000412801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000412801-mRNA-1"/>
        <property type="gene ID" value="DME_0000412801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000412801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16418" checksum="E6CDD31CD9B2442F" modified="2015-12-09" version="1">MKLLFDKKNVPNLDLALSSNDNNMPEYVNEGYLQSPKKMIYVQSRFTRKVGSLIDLDLDTSDHKFKTIEKNDENCCVNKFNYMNEMTCKESIKARKRKTFRNTSNENFVRLRIDRKKLTFKKFSKYRKKRICAQKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBN7</accession>
    <name>A0A0N4UBN7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DC_STAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8511</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBN7"/>
    <dbReference type="WBParaSite" id="DME_0000462801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000462801-mRNA-1"/>
        <property type="gene ID" value="DME_0000462801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5784149at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000462801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10385" checksum="789AA88262335995" modified="2015-12-09" version="1">MDRDARLRLFMEDQARMSSLMEDLSWIRRHLERLEFLVTLLVAQIGITILLIGALIIYKACCVENTDNDFTFKENKANLMNPQPGKSGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC93</accession>
    <name>A0A0N4UC93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS497</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC93"/>
    <dbReference type="STRING" id="318479.A0A0N4UC93"/>
    <dbReference type="WBParaSite" id="DME_0000487601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000487601-mRNA-1"/>
        <property type="gene ID" value="DME_0000487601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000039">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000034">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="215"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000487601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46542" checksum="8E45E9D092532B55" modified="2015-12-09" version="1">MIKLFAETNYDNNILPSNETTIVIVELTVQSITDISEITSSFKADVWFSQIWHDRRLAFQDQNYCLKNLSLASHKLPKLWTPNVCFVNSKKVEVHTSPSQNILLLIFPNGTIWLNYRVSLQGPCHLDLTYFPMDIQQCSLIFESYSYNTAEVRIVWRDWEPISIPDSNSRKLPDFELIEFINKNLTLLYTAGLWDQLEAVFLFRRLYGYYILQAYLPTYLSVFISWIAFWIDTKALPARITLGVSSLMALTFQFGNIVKNLPRVSYVKALDIWMFGCVGFIFLSLVELAMVGFVDKLQGKRKRVKRTKESIQQHISTAIRIATNHEKHLQTSSISKIDKNLLNNEKKHSTIREFQRMPAFIQRISSKIFPLMFIAFNLFYWFYYIGMSRNFQPQPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC99</accession>
    <name>A0A0N4UC99_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS504</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC99"/>
    <dbReference type="STRING" id="318479.A0A0N4UC99"/>
    <dbReference type="WBParaSite" id="DME_0000488301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000488301-mRNA-1"/>
        <property type="gene ID" value="DME_0000488301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11364">
        <property type="entry name" value="RNase_PH_PNPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008805">
        <property type="entry name" value="PRK11824.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="662"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000488301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="748" mass="83563" checksum="56936E12ABF5112E" modified="2015-12-09" version="1">MIFPMRWLFHRILMKYVNRQIHFRCISLSSIVFSSKISTNIGSILEFEFEAGHMARFADGAAVVSQGDNAILATVVSKDESEGKNDFLPLTVDFKQSGSALGRIPTNFLRRELQMTDADVLASRTIDRSVRPFFPSNYFAETQIICKPLALDDDGDPVILGLNAVSAALNVSNVPWNGPVGAVRIGLIDDKVEVNPSREAMKNSIINMILVGCNDGKRIVMMEMDGKEISCESLAICLDKGSSAIGKVVGAIDELRANVGKEKRVVMEEQINEELIEQIKKMSEDRLYYILSDQKHDKISRDLAIKELMDDVTDSLEEEFSDELRQIFYELVKNTLRNMVLETGIRSDGRSVNDFRPIKIKVDVYKKLHGSALFQRGQTQILTTVTFDSPATAFHPDSISQLLGSQRRKMFMLHYDFPSYATNEIRAQSRKSRRELGHGNLAENALKHVMPEQFPYCTRLACEVLESNGSSSMASVCAGSLALLDAGVQLKAPVAGLALGLFLSDDQNNHKILTDLTGMEDYYGHMDFKIAGTYNGFTAMQLDLKLPGIERKIFDEAIIRGKEGISYVLDIMHEVQPMPRTSFKSSVPVFETIPIQIYKKQILFRSNAFNQKLIEAETGVKIAIEDEANISLLAPNKTKLEQAKILMNKIFEDEANIELTFGGLYKAEITEIVENGVMVKLAKGLKPMFLKNINLDVRRVAHATALGLEVGSIITVQYLGRDSITGQHRISRRTIQTTALPVENLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCB8</accession>
    <name>A0A0N4UCB8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS526</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCB8"/>
    <dbReference type="STRING" id="318479.A0A0N4UCB8"/>
    <dbReference type="WBParaSite" id="DME_0000490501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000490501-mRNA-1"/>
        <property type="gene ID" value="DME_0000490501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819511at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000490501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38581" checksum="9FAFF0A4768F4BF6" modified="2015-12-09" version="1">MCHQVVYNTYWFNEDQKRQIVTLHNQLRASEPAADMQELVWDDRLAALAHGHVQRCDAWHRSAYERRGHGYSYIGENIWWSNEAYLRHDLTGVIMDFYNEKPFYNYATMQCWRGAQCGHYTQIIWANTCAVGCAAVHCSGIRNGRGIYRGHIIVCNYGEGGNAYGQRPYQMGERCSRCADGGRCTNENLCAPRCHGVRYGTQYQITHFLPNVNQANRNIKLAGQATQKQVPLYPYVCKDSDRNCQTWAQHGACEKNRAYMILQCPASCNACTPWISTVNQAKICADKHRYCSIWAEIGECNRKYQKFMTEFCQRSCNMCRNSKSETMTEKKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCC8</accession>
    <name>A0A0N4UCC8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS537</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCC8"/>
    <dbReference type="STRING" id="318479.A0A0N4UCC8"/>
    <dbReference type="WBParaSite" id="DME_0000491601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000491601-mRNA-1"/>
        <property type="gene ID" value="DME_0000491601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000491601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34950" checksum="B0FA0A525E08E9BD" modified="2015-12-09" version="1">MGREDKQLWKSNYFLKIIKFLEEYPKCFIVGVDNVGSKQMQEIRHAMRGHAEILMGKNTMIRKAIRGHLSSNPDLEKLMPHIVGNVGFVFTKEDLSDIRNKLLENRRGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKISRGTIEILNEVHLIKVGEKVGASEAALLNMLNIQPFTYGLVVQQVYENGMVFSPNVLDVTAEDIRSRFLEGVRNVAAVSLSIGHPTMCSISHSIVNGLKNLLAIAVETDIDFKEAHMIKEYLADPSKFAVSSAISAPAASAAIKVEPIPAQKEEMKEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD22</accession>
    <name>A0A0N4UD22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8997</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD22"/>
    <dbReference type="WBParaSite" id="DME_0000519801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000519801-mRNA-1"/>
        <property type="gene ID" value="DME_0000519801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867068at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000519801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33265" checksum="41BF2A620E18EF00" modified="2016-06-08" version="2">MEKFASDCLAAQTLANSVYFILLITVVAIISMIGIIVQIIVMKKYVICMAIHENTRILLIAHQIYLILHCVARIVAHTADLIVFHWNYHDPCMYLSTPLRCFIIRTPVTFTFCILPCSMLLIVAERAIGTYWSAKYERMGRSLAFILILCEVCFIKLIKFFILYNKLQQVRQNLMETDLSHRYQLKENITSITTIAPLILCHSIFYSIFTLAFIIYFLTKPKFSQDNFAIFLESKFILFFFGKIEIMVVDIIFCGNFEEQFFPFKLFILEETINLNDKVISDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDC4</accession>
    <name>A0A0N4UDC4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9122</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDC4"/>
    <dbReference type="STRING" id="318479.A0A0N4UDC4"/>
    <dbReference type="WBParaSite" id="DME_0000532301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000532301-mRNA-1"/>
        <property type="gene ID" value="DME_0000532301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000532301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34333" checksum="F0FA5CAC412965C1" modified="2015-12-09" version="1">MEQNPKVKKKECKGFQECDEKYSDHCSATYQWIGGIAPSTNVSQNKLLLRCCSSKWSLEPVDRGIVKVTQGQIVSGGEQKIQNRHVFDYISNIEKHVNDDNLVTYMVSFKRVYCTTNLQNQVLDDTAKIIISTLNSSEIRKRPRKIKEPKQALKKVISLSAPTTKSSLSTLSPLVQFNLNSPVYQEKQQNLFGGGATRRDLQIPQQNQFPFSNQDRNNFVQQQPLTKAFPPQRNYVPPNEYGASPLEEKNDLFNNAYSKENAQRYLPENTDYGSSSADYFQASSIDPLLPLRQLLQAIFRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDF7</accession>
    <name>A0A0N4UDF7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histone H4 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9166</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDF7"/>
    <dbReference type="STRING" id="318479.A0A0N4UDF7"/>
    <dbReference type="WBParaSite" id="DME_0000536701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000536701-mRNA-1"/>
        <property type="gene ID" value="DME_0000536701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000536701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="42150" checksum="1F72638070D511A6" modified="2015-12-09" version="1">KFSQSKSDDGGFNLQFEFHWHCEGIFRKYYFFHKVDFLANFYCSCGFHESRLVYEGAVLVCEWEDCMVRFKYLNGDAMFDEILKYVNHINLHIELLDEKDRDNRCYKCHWKGCTMKFKNKNNLKIHVQHHSGDKAAACPFCGCFFANNSKLFYHMLRRNLSKGNSTIEKRCILCHKVFDSARLLREHCRRHIVNLKCEYCAVMVGSPSALRRHILTVHLKRKIYRCNQCKGRFILFLFELNILHSVLHSNNLEFECAQCGSKFRWQKQLTNHVRKHQQDYTPYTHLCHLCSAKYTNGFGLTRHLKIKHNFTIPTGFTRFQYKKCADGFFRLQTRRCLSQALAKDNAHFNEAHYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDS5</accession>
    <name>A0A0N4UDS5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS606</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDS5"/>
    <dbReference type="WBParaSite" id="DME_0000550001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000550001-mRNA-1"/>
        <property type="gene ID" value="DME_0000550001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000550001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10907" checksum="C138295700F7963C" modified="2015-12-09" version="1">MQIGRIAEEEVDFEHQPDFTLNFAKNRDPARLLDFSRNRRPYQRLSKINLTKPRLYTDCMKNAGNPKLTWYHPPCCTVESKAERQQLLSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDY6</accession>
    <name>A0A0N4UDY6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9305</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDY6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDY6"/>
    <dbReference type="WBParaSite" id="DME_0000556401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000556401-mRNA-1"/>
        <property type="gene ID" value="DME_0000556401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000556401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24758" checksum="F471FF4278BB5462" modified="2015-12-09" version="1">MPKNKKKWRKMQIARNTEAGSSSIIYFLFWIGMFDFNQCDPKRCSGRKLMRFNLVKQLKLGSKFHGIVLSPTGTSTISPADADFIKMNGLAVIDCSWNQVDNTPLHRIKASKYRLLPYLIAANPVNFGKPCQLTCAEALAAGLYIVGFPDAAEAIMAKFKWGFNFLKMNRELLDNFASCQTASDIIKQQNIYLENIKKEVAKSNTYELDLPPSESEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE26</accession>
    <name>A0A0N4UE26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS651</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE26"/>
    <dbReference type="STRING" id="318479.A0A0N4UE26"/>
    <dbReference type="WBParaSite" id="DME_0000560601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000560601-mRNA-1"/>
        <property type="gene ID" value="DME_0000560601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849009at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000560601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="53089" checksum="CD7BDDBEE6339FBC" modified="2015-12-09" version="1">MQFLSQIRRLEGQLEAVCASQNSVEKSHNYANNRLFDGSSAKRRDDYQQLCGEALKYKNLKQLFGNERALLKAREEQLKMQLAEMTEKYESLFKIIRENQFENDSVSSKNGVDQIRNWKNGMENGMQPKTLFEARRIISQLEDDLRQANETITDLELKLVDVKENCGNDLINQNDFLQRKIDELEECKRNFQRQFSDQELTLHQLQKDLEKLLGEKDMFRMRCDELEKVNENAIKQNFDQSEAIKALRLKLSHANEVQNESARKYISQIETYQKLLKEKEAERTAFIQQLCYDDQMYSSAAFMDDLKETDKKMDELKYINERLQKKESELQQEKAKCSAMSEALVEANNALMDVKNEFIETKNRAKMLEARIIKLESELENANGKFKIEQLSTKILESANEELMDLLGKKTCASKSKKSEMNPLANEFLDLRMDLSPMDVNIALAPTAVNTANQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE64</accession>
    <name>A0A0N4UE64_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE64"/>
    <dbReference type="STRING" id="318479.A0A0N4UE64"/>
    <dbReference type="WBParaSite" id="DME_0000565001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000565001-mRNA-1"/>
        <property type="gene ID" value="DME_0000565001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829382at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="286"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000565001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41290" checksum="FDC20FB4CB50CFC1" modified="2015-12-09" version="1">MMERIVERDDNSIDILTLDTPNLANVLSSSEFPSTAEIIQKCISVNPFELKFREANRRISQFPANLSLPTTAGITLLKLPSTLAHSPTIFSNINVLSADFENEGFKTAELSRLVQQGEFFLSFLSSQISRSPRTADVLNAVLDMHTDRLSTIGYGNATIATSRPLQPSVASSLLSGAIPSTSANSDTRSSLIFCPPCSSSSPSNLLTSFVTANNPSSLDSTLFSQAVISRPQSTMPSAQQPVDVSLQTLSRSGRGRGRSSLASELPPDERRVTILERNKAAAVRYRKRKKEEHDEMITRVHVLQQENVALSTQNQVLRRELERVNEMLKLHESRCVCRLGNDGLRAGSPAKVDIMSNTNQHETSSYLPQQLLMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEE3</accession>
    <name>A0A0N4UEE3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9337</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEE3"/>
    <dbReference type="STRING" id="318479.A0A0N4UEE3"/>
    <dbReference type="WBParaSite" id="DME_0000574401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000574401-mRNA-1"/>
        <property type="gene ID" value="DME_0000574401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="840771at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000574401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39330" checksum="428154C9A33A0628" modified="2015-12-09" version="1">MGTMKQTAPIFSLHGIIGKAFSGLVDVQLAKREGRNNFSALRIISLEVVDYETIKKEVWFLNWLSHPNLASIEESVTVGFDVYIFSSYYDLVFSSAGSVLHIIQTHCKYGLPEKAIAQILKNLLLAVQYLHGQKIVHRSIRCSHVLLASNGQVKLSGLRNCAFLKHNHLTGAKNVLHDFNEDLVEGLLWLAPEVLKQDLNGYGLLSDVYSIGITLCEMANGFPPFFDMDRLQMLYEKSKGTSPRLLDCTTLVEDENFVSNQNQRRNRRFTEHFHAFANICLKPSPEHRLPILKLLSHTFVRSIKKNRSFLSLIPNISPVHKDKAEMMPEVNASRSHSPAALSWRFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEV0</accession>
    <name>A0A0N4UEV0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3099 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS864</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEV0"/>
    <dbReference type="WBParaSite" id="DME_0000592501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000592501-mRNA-1"/>
        <property type="gene ID" value="DME_0000592501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000592501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7530" checksum="1DCF57578F6A6D78" modified="2015-12-09" version="1">MPFSHELSETSVPGPVIARRRWTSDKQATSTRYLGRVWIMIVTSGSVLTFHATTAKHLAARAESFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG21</accession>
    <name>A0A0N4UG21_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS9526</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG21"/>
    <dbReference type="STRING" id="318479.A0A0N4UG21"/>
    <dbReference type="WBParaSite" id="DME_0000641501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000641501-mRNA-1"/>
        <property type="gene ID" value="DME_0000641501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN59553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000641501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49496" checksum="3A8369C8A274D6D2" modified="2015-12-09" version="1">MPNELITVQFGQCGNQIGDAFWRSLCAEHGIAPNGTLIKPELDAQDLKRVFFYQADDAHYVPRAVLVDLEPRVINSIINSEYRSFYNAENIFQSKSGGGAGNNWASGYIQGREAQEALFDMLEREAENSDYLEGFMLCHSIAGGTGSGMGSFTLEKISDRFPKKLVQTYSVFPVIRKGEASDVVVQPYNSILTLARLIDHPNCVVVLDNTALHRIATENAPNSISASSFALINSLVSRIMCASTATIRFPGAMNTRLINLIAPLVAYPPMRFIQTGFTPLRDGEACVTKTSVGDVLRRLLQPKSMMSSATMEDDVEHCVLSAIAILQGRIDPSEIYVSLGKIKEKNQIKFAPWGSGSLNITQCRLSPYLPLTNRVSGLMLCNHTNTASLFQESLTHCETLFKKKAYLEQFLKEDPDILQTLGDSVECVREMIDTYRSATKANFIDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGP6</accession>
    <name>A0A0N4UGP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CACTA en-spm transposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001188">
        <property type="protein sequence ID" value="VDN59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGP6"/>
    <dbReference type="WBParaSite" id="DME_0000667901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000667901-mRNA-1"/>
        <property type="gene ID" value="DME_0000667901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863414at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000667901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35424" checksum="E1A54838DB6AAC9C" modified="2015-12-09" version="1">MLTLELGADLCNMFLSQFLLFPIYYINRYVCIFIMHLRLVCCCLKSYGILNLSKFATNIVEMSAAIALLVPQSDIEDEVNSLARCPPYRYLKVRIFDISDLPYQVRDDFPGMVGSRCFDNEIAGLMDGNRGDQPTLKRFSRYNQSMYSPSSICVFEPSSSSPSFSSPSQAKHSQTCSKNGKFKAGMFSGHWTLRDKKEIRPSIRDISVLSVGKMNSDGTIHTNTNKESQIPNCRNTCSKSWNMTMRAARPKEPFESNFNDETLKKTSKIVSKRFSNQGSYANEYFKRRERIIPIEVQENRKQFDLQGMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGQ3</accession>
    <name>A0A0N4UGQ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9713</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGQ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGQ3"/>
    <dbReference type="WBParaSite" id="DME_0000668701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000668701-mRNA-1"/>
        <property type="gene ID" value="DME_0000668701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957665at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17101">
        <property type="entry name" value="FERM_F1_PTPN13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF5">
        <property type="entry name" value="PROTEIN EXPANDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="53"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000668701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="49439" checksum="BEA4ED080E1E3F0D" modified="2015-12-09" version="1">MERINVNERGEESPCCSRSENMEKANSLKFPPFNHSGVYIIPSLSVNLSIGFKYVQVETLSDETLLLAVHEKCKVRDVYLCCCSHLNIKNDQILGLALRNPSEGIGCNHPRYEYFFLEFDQSISKYAPKHSRFSYSRNDLINNRPFLMLYIRVRLFVDMVQLIRCRNTLEQYYLQLRHNLLDQWSASNSVPEERCWEMTALALQVDQNREDIKIEQYFPLWVINIRGFDFIRQNLAKIQKHFKNISKIGSMQEYCQQASRSPFALNCHLYGLRRSKADVVDNAVIGITPKGVDICGVENDGERILLQSLQWRKISKLSFDKRKLSIAGVGNSSSISLYAQSEFKARYILEFCRSFHQATIHSHSQLRLDQCKHMNTFPRKRKLLWMKFRKMRCHKGKLENNYSTLSKKNRKSVFPFLQKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGX7</accession>
    <name>A0A0N4UGX7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS1380</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGX7"/>
    <dbReference type="STRING" id="318479.A0A0N4UGX7"/>
    <dbReference type="WBParaSite" id="DME_0000676601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000676601-mRNA-1"/>
        <property type="gene ID" value="DME_0000676601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN51407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000676601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18939" checksum="48EA9E51BEEBB213" modified="2015-12-09" version="1">MFSYIYCHYLILRSSLTSILLSSRALCSSSGSNSTSSHNHSLRVMSFEVKRAQEAQPGGDTIFGKIIRKEIPVRIILEDDEILAFYDAHPQAPVHFLVIPKKPIEMLQAADDSDQALLGKLMLTVAKIAKSLDLKDGYRVVINNGKHGCQSVYHLHLHVLAGRQMNWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH13</accession>
    <name>A0A0N4UH13_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1421</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH13"/>
    <dbReference type="STRING" id="318479.A0A0N4UH13"/>
    <dbReference type="WBParaSite" id="DME_0000680701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000680701-mRNA-1"/>
        <property type="gene ID" value="DME_0000680701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906921at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000680701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17759" checksum="BE0E07D6452DBB6A" modified="2015-12-09" version="1">MADESLSWAFGRRCKSGNQENALIGHRRLSESNLNGPLCENTILSLKSMGNACSRDRRWQSEADTVNPYPEVEANAIDDELSEGVLTKIWSVRGFGQAWHWLHEKRKVESMPLNAYLTYITLPWSAILDDLLPERPRRSILTFDLNAPDMKNAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHF0</accession>
    <name>A0A0N4UHF0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1556</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHF0"/>
    <dbReference type="WBParaSite" id="DME_0000697701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000697701-mRNA-1"/>
        <property type="gene ID" value="DME_0000697701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000697701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="45259" checksum="90E123FE16331DC2" modified="2015-12-09" version="1">MFLGVAGAVATVTVVVVFVVILTVVGAPIGITVFIIVVVDVVAVNVVGIIGAIAIFVVDIVVATVVALVISVDAVIVVVFIVVATVVSVVVTTIGVTTVVDVTVVVIIVVNVIIDVIVTVVVVVNNVSVTDASVVGVVILVSITNVTVVITVVATVFVVVEVAAVIFISVIVGGVVTAVDVAVAIVIGTIVVAVVLDVVIILVIVIGVLAASAVDVIVIVVTVINVAVVIVVIVAITGVDAVVGIVIGIVVIVVIRVAVVGVIVVATIVGNVTVVNINAVSGVVVGGITVVIATVVNIAAIPVVIGIVVIIVLLVDVAVVVVGDFIIVVVDVVVVIAITIIGIIGVVTEITVAVGLITVIFVTVTGVTVVITIVSVGVAITVVTIVVIAVVNIVSGDIVAVTVASVTVDIIATALFDLIVSTPLTSFSLIALFLVLFVIMLAICLINWILDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHH8</accession>
    <name>A0A0N4UHH8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1563</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHH8"/>
    <dbReference type="WBParaSite" id="DME_0000701101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000701101-mRNA-1"/>
        <property type="gene ID" value="DME_0000701101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847693at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000701101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60071" checksum="316980FCC263EC5B" modified="2015-12-09" version="1">MKECEWRVGIPFNIPQRWNCDEIAEQNFTMNKVIVYTRTHVRIPAIKCSNVTRTVCTKVFFRFSLSVISDQTVTSATSSHFCRNLDRQKKTDGEELIQVSPNKWITNNELQYSYGWLGVKCQSTTNFIFIKGKIFLYDGKGLLSDFDNVERCTAISGKCVTNNGIVLWDGEEVGKSCPYRKIGEFDAQLSGSHVIINKLQTSFIFKENRTIMNSNCNFIEPYLMNGVIIIDKGTNNLTNNLRKQRSDPESELIMKEVSGREETGLNEFDPRNIKYQYLFNVLQIEFRKQLIKLYQRSCQNRNNLLLLIEWLSTINPTLLQRNDIIAKRTKGKLLIAPCSINASEWKTVDFKAGIVSKFEIEKINTDLEILAQKLGITNPVHGLTREESLRELIVEQGEELVNQLETQFDETTELMEQELSEIMKRWKLITFGIIVFVILIMIIVIKLKFELIQSLYRSFCIRTSNRRVDNSMELVRVPTPKLEDQNPPNTIQYLPIVLSVNSFHPVSSGMSGNRKEINSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHL0</accession>
    <name>A0A0N4UHL0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1597</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHL0"/>
    <dbReference type="WBParaSite" id="DME_0000704501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000704501-mRNA-1"/>
        <property type="gene ID" value="DME_0000704501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000704501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61615" checksum="9CD48464BD7EBA7A" modified="2015-12-09" version="1">MVGRLKMWIAWSWSYLWTFWFLLVIALVYILRGPLRIAESLENASTYFNNLTPKFYVALTGTSSLVSGIILIFEWWYFKNNSGDNGSNSEDGSDDDGVDQRSRSVPECKVWRNPLALFRGAEYQRYTKMTGKEPLTFYDMNLSAQDHQNFFTCEADAGKQDYEIMQIAWRERDSYSRINAAYKALDINQECVPALILLAEEECETILEVEQMLKKALKAAEVIYKKNQSHIHYDLANDPVHRRDVNLVVYIRRRLAMCARRQGNLREAAKMMRDLIKDFPSLNVMNIHENLIEILLEQQAYADATAVLAKYDGNISLPKSATICFTSALLKVRIVADKFAPDFVMRRGFSAAELNAVDAIHRAVEFNPHVPKYLLEMKPLILPPEHLLKRGDSEAIAYAFWHLQHWKRIEGALSILQCTWEGTFQMIPSPLEKGNLFYPYPTCTEAADRELLPAWHDVSVYPKRDLPFFTVFTVVLCLLTALMAIFTHRLPKELIHPFSSVGSIFYAVIDCLYNLIPENAVNLLASKPITPPQNDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI06</accession>
    <name>A0A0N4UI06_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1687</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI06"/>
    <dbReference type="STRING" id="318479.A0A0N4UI06"/>
    <dbReference type="WBParaSite" id="DME_0000721601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000721601-mRNA-1"/>
        <property type="gene ID" value="DME_0000721601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870215at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF15">
        <property type="entry name" value="PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000721601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="619" mass="70327" checksum="F5187CD6586D4605" modified="2016-06-08" version="2">MGGSESKFMQEIEIGEEVPECAGIHRIWSNVYPCMQTRKYRRTLFMKEFSETDTSETRSFYENGIKFRFGKSFIMLRQLRHPYILKYIISKMDVNETALLTERVQMLDLVVDTQTPIEIHTGLTDILNAVVFLHDKAKICHNNICPSSIFTTLDGRWKLGGFECAQKTGSNRYWVQSDFVRSVKFADFAPPEDQLMLTADIPPTARDAFAYGKLIIFVLPFLKGHLIEETLISLEDVASRLTSNDSIRRGELGSLFHSHSTAFMNTLSIMVDFLQTIHLKSSKQKDAFFQTICNELRKVPYEVIGKRLVPLILSRYVILEDGAHKGLLPFILEPCSDNDLELKGLLPEHFYKVTVIPEILKMFHVHETSIRLALLAHFHIYMYHFNSVQLNGIVLKELKLGMQDADDRIVRASMHALTCLVPLIGGPQVTGLVHSKVFADGIPKNIDLHLPKIDQVLSMPKKISKNILASPISPLSQLLTDDLVDEPNIKLQLLTPTVNSNEPSFMNVHPTKNSLDEEWSLDWEDKLDLAESKLNLETHSIAATVTYGIPEIDKQILKNSEEAEPDYFVDMVPVLKKRPSVPVEQESQQKKNEEAKWSMFSKLFIPSQTVHDNNASSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIQ3</accession>
    <name>A0A0N4UIQ3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10079</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIQ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIQ3"/>
    <dbReference type="WBParaSite" id="DME_0000749401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000749401-mRNA-1"/>
        <property type="gene ID" value="DME_0000749401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000749401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60514" checksum="A05DEDFDBC55EAFE" modified="2015-12-09" version="1">MKQSLVQLRFRKFCILPIGKLYGNYRLLSLSLEYRSVIRSTRLLLYNNDLDETLKTYELIWSLVEIIFMKSHDSSIVIDLITWARLCFPFTYYVDEISPCLRQSKIRSLDKRIFWQQIAYFLLSGLFKNAITMLETYGQIADDEAVRKLADEIRDLCMEKYFESNRDAEMIALLLSGDQETLLSLSHLVDNWFELVPAYALFIRPYAALSDLHEIAKTCANICGCNDHPIDDIISSLFSLDAPRALQNIARASADWWLAAHLADLLQKADNRTTTVFGVDIRQHLLVDYALSLFSYSGLWQISFDYLKECGSDGFEKLELLIPAVPLNSDITAIKLNDLCLDLGLNHLCADINKAMAYRMLRHKEWGSALTWALRSVDTSLHSAIADYILHFCPPEVISSIAVLEQMSEIMLKTPALVFLHEYRKFQNLLRDGDKTEAVNLLVTLIIYDFAPDKFRANLFNDLITILNLDCGVVNKERTMQVLQYLAINSTSEKRLDEENMDILTSEQLQVNILRQALLKNLLTAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ88</accession>
    <name>A0A0N4UJ88_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1927</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000038">
        <property type="protein sequence ID" value="VDN51954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ88"/>
    <dbReference type="WBParaSite" id="DME_0000770901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000770901-mRNA-1"/>
        <property type="gene ID" value="DME_0000770901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834857at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF37">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000770901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36984" checksum="5569E95748D55298" modified="2015-12-09" version="1">MIRSILLYRSETWLVRVEDIKNLSVFDHSCLSKDEERYRNGTGVALCSMAAADLCSLLLILSQNIMQIYSNFDDDTLLMGIVCKVMLFSTHTVTSISIWSWLLLSTLRYLAIRHPLFHLRLWQMPYRALACIVKGFHYDVTNGYWQENTTSIKGVFEEEFSVSRIKHEGRYSLKINIKAVKSKLNPLRGLKLLEEEFSLTSAVLNLWLLIAVHSSTTGCVQMPLFDTLATNRLFHLIESLWSFTVPCIMIILMDTLVIMKNLLALYLAKLIEHIKSPFTTPPFKMFTAKNKRKTKSERIKKYRRLLKMLFEEKQTLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJB8</accession>
    <name>A0A0N4UJB8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10155</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJB8"/>
    <dbReference type="WBParaSite" id="DME_0000774501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000774501-mRNA-1"/>
        <property type="gene ID" value="DME_0000774501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855819at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000774501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28854" checksum="43A4A90A63817B15" modified="2015-12-09" version="1">MMRTANIYEIFLIFFGDIVATITNIIVEQPLISCSADAIYAKWKTKTTFNGNVTVQFVPNPNCYQTLITNNQIELLIPHHDCRLNRMRFISRAALMFESSVLITSNEKEIHKIRIRLIAVPHCKYKVQGHESKNIANTDQLLKHVWTCGIKAIDNLCFIVRNCFMIVNDSRQQLIDEHGCLMINDTIQAELDYNEKLKVTWKTKVNKIRLQKSSIYFRCQIVLVIDEKDCSRPNCSAKPRSVTRPFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJD6</accession>
    <name>A0A0N4UJD6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1963</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000039">
        <property type="protein sequence ID" value="VDN51990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJD6"/>
    <dbReference type="WBParaSite" id="DME_0000776601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000776601-mRNA-1"/>
        <property type="gene ID" value="DME_0000776601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000776601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8038" checksum="E47D097C3B4F7BC0" modified="2015-12-09" version="1">MSIINHSDMEKIVQRLEAATLRLEALSSQKPVLAPKPGMNTMSPTSSSIYNLLGKLEDGYRIHDLSASSSYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF8</accession>
    <name>A0A0N4UJF8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF8"/>
    <dbReference type="WBParaSite" id="DME_0000779301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000779301-mRNA-1"/>
        <property type="gene ID" value="DME_0000779301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796971at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000779301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26976" checksum="D95C01BC342511AF" modified="2015-12-09" version="1">MNVPANYTDDNGVDKDLWSATDIYDDEIAKIIKNDSINHINATKEGSSSVIIAWNFFNDFPWLLWTIIAVGILIVFGIAITIITFMLCNKKKIVRRGNGYMSCNFGSCESVTQSMWSKWVICSPKFIFKRQKNLKSMRQNSASNMDPYMRPPLPPINGFNKNDDGFQGSFLPSLRLAPINNKVIAPLAKSDETAEVTVLHSNPAGNLILGTQIGSIHGIPVLEIDDYQRRSLPIPKLDDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJV0</accession>
    <name>A0A0N4UJV0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2082</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJV0"/>
    <dbReference type="WBParaSite" id="DME_0000795701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000795701-mRNA-1"/>
        <property type="gene ID" value="DME_0000795701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000795701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8923" checksum="4F3E9B41959E574A" modified="2015-12-09" version="1">MIGDEATLATGKFDDQQKFIGVLLSNFEKNFYYGSTTLSQGIHKFQSDGQFTIFISGSFSNGSYGYTPAYNGIFTPAKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJZ8</accession>
    <name>A0A0N4UJZ8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2138</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UJZ8"/>
    <dbReference type="WBParaSite" id="DME_0000801301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000801301-mRNA-1"/>
        <property type="gene ID" value="DME_0000801301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="7">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000801301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10634" checksum="D795F327852A6320" modified="2015-12-09" version="1">MSRVSADLQWLCIRKTSSFIRRQRGVPKHFSTEKFNLKGLNSIRYNGLVHKKGINIEVSPDGKGIILSTKKKRQPLSVRRGKRSRKMDVKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK22</accession>
    <name>A0A0N4UK22_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2169</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000048">
        <property type="protein sequence ID" value="VDN52196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK22"/>
    <dbReference type="STRING" id="318479.A0A0N4UK22"/>
    <dbReference type="WBParaSite" id="DME_0000804401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000804401-mRNA-1"/>
        <property type="gene ID" value="DME_0000804401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF23">
        <property type="entry name" value="LIPASE_GDSL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160709" evidence="2">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000804401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26430" checksum="BC44F99EE248AFC2" modified="2015-12-09" version="1">MQIFAIRILIVVFYIENICFSSGFTNLAKQTNRQNETNSYGTHRKRKNKESSESSSESDSQSDENFDNAGDYYGSLHISKIASGFVNKKTFECPRVKTTLHTGDNVANLSPEDINIIAALGDSLATGQGLWLGTNINFRGAAFPIGADANIDGLVTFPNILLEFNEKLYGVSHGMGTREQLPDYQLNCAEDGAKTSDLFDQAKLLIHRLYQNEGKKDRLKNFWIMVTIVVGTEEVCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK36</accession>
    <name>A0A0N4UK36_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2184</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK36"/>
    <dbReference type="STRING" id="318479.A0A0N4UK36"/>
    <dbReference type="WBParaSite" id="DME_0000805901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000805901-mRNA-1"/>
        <property type="gene ID" value="DME_0000805901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834955at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7808" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000805901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13135" checksum="BFA4CBE9D718F2BC" modified="2015-12-09" version="1">YKLESENILEFRKLVCLTKDRSFKYGSEVAKCHLVLKDEEDEPGRRASDNTGCFKKRFNASVERVYCDIFCPGAYEVFHSAFDLFHKSCFQYHNYQLSEQNENWSKFIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULI1</accession>
    <name>A0A0N4ULI1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2571</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULI1"/>
    <dbReference type="WBParaSite" id="DME_0000865601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000865601-mRNA-1"/>
        <property type="gene ID" value="DME_0000865601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000865601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8200" checksum="6E19A813587C42E8" modified="2015-12-09" version="1">MSTVHEKKFLPFHSMFVLYCDVKKHFIEYSHCIIASQTGALNFETTIRGNRQAVQIGLETTVIKYYEGCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULN8</accession>
    <name>A0A0N4ULN8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10453</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULN8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULN8"/>
    <dbReference type="WBParaSite" id="DME_0000872001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000872001-mRNA-1"/>
        <property type="gene ID" value="DME_0000872001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF21">
        <property type="entry name" value="CERAMIDE SYNTHASE HYL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="90"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000872001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="38696" checksum="11390EF044DFC74D" modified="2015-12-09" version="1">MGIWDDSFWLPENVTWNDLKSTSAVRYPDVNDLYYVIKYTLILLFVRILVESFIFLPLGIFFGWVDVSYGTINRISAHLCFGFAGKSKFKRVAETAWRFLFYSCIWLAGLFILWNEPQMRDVAECWRNWPHHPISESVWWYYIIETSFYCALLFSSLAFDIKRDDFWQMTLHHTITIILLFMSFTMNMVRAGTLVLFCHDLADIFIELGKLFRYAGWETALLIDFIVFFFLWVLTRLIYYPFWFIRSVLFDAPALIQSDYRWQNLLEKPIVPRILATMLFCLLILHIFWTYLIVKVALTTIHGGELDDIRESDETGNNEKSAKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM78</accession>
    <name>A0A0N4UM78_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Centaurin-gamma-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10547</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001224">
        <property type="protein sequence ID" value="VDN60574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM78"/>
    <dbReference type="STRING" id="318479.A0A0N4UM78"/>
    <dbReference type="WBParaSite" id="DME_0000893901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000893901-mRNA-1"/>
        <property type="gene ID" value="DME_0000893901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="84"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="306"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000893901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70863" checksum="FC076B7F811E659B" modified="2015-12-09" version="1">MNSSREMHEISKNDLDQSIYNRDELFIDSNIQSSNFVSTTAVNHLQTPLSTPNLHRKNRRISNLFRTRENENHKDINMGIGRAIPVKQGHLYKRSSKTLNKEWKKKYVCLYSDGRLSYHQNLKDYMDKESSSKEIYLGLATVRIIGQQRPRSTQHSLNQLVNNDINVIRRESFEQSDKTLLPVNLPVDFASNKNEERSKKFEECSDDQQILNSQRTNNLIVTPNSAISNKRKKIHRRGASNAKNNDEEIDCEFEVLTCDEKRWEFSAVSVEERDEWVMAIEKIIEKTLQSQMSDKEQKNKRIHSSRNEIQALKEIPGNEICADCGAENPDWASLNLGTLICIQCSGVHRNLGSHISKVRSLDLDDWRIEWLLVMEAIGNRKTNSIWEYNAPVNKKPTADSSYEEKEKWIKMKYEKKSYFNTKSIDSHRSYGIQLLDAVFNNDLNILLPILPLCNENDLRTTVDVNDKRTALHIACSNASAIFTQLLVWYNADIYMLDDMGRSALWHAQTSGAHDCVSILLNAGLDSSYGIPSSNAYSGIVAGGLIVGSLAAREYCHPNDMLKNNDAKLRKYTDKYTNNRLSKSSSQLQQQQQIQQSPSSVLNGFHQRASDAFECLPTSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMC8</accession>
    <name>A0A0N4UMC8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2799</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMC8"/>
    <dbReference type="STRING" id="318479.A0A0N4UMC8"/>
    <dbReference type="WBParaSite" id="DME_0000899601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000899601-mRNA-1"/>
        <property type="gene ID" value="DME_0000899601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5802114at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000899601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16816" checksum="FC097DADE9AD6CAB" modified="2015-12-09" version="1">MMRISKCHFGNPCRLCKCFILYTDRDKGTSLNPYGIVAEPYEITEDRCLALCLSDKRCKTVVYGLVGGRNIFACEFYENDDTMDFIYVPFVNSYIPRKGECDTSCKHFILSKMIYFSHILKLGSILLMAYARQFKLSKRSLQQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UME6</accession>
    <name>A0A0N4UME6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10564</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001225">
        <property type="protein sequence ID" value="VDN60591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UME6"/>
    <dbReference type="STRING" id="318479.A0A0N4UME6"/>
    <dbReference type="WBParaSite" id="DME_0000901801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000901801-mRNA-1"/>
        <property type="gene ID" value="DME_0000901801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000901801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15838" checksum="03B5EB47D1DE8547" modified="2015-12-09" version="1">MRQTSIRFALSAINRQYLIEKTIRVDHIGELAANQIYAGQNAILANRPISSVIQKMWNSEKEHLNIMERLCAKYDVSPTRLTPILSVIAFTLGATTAALGEKPAMACTIAVEELIAKHYDDQIMKLIDDDPKVHSELLKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNR7</accession>
    <name>A0A0N4UNR7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Btz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3232</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000115">
        <property type="protein sequence ID" value="VDN53259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNR7"/>
    <dbReference type="WBParaSite" id="DME_0000956501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000956501-mRNA-1"/>
        <property type="gene ID" value="DME_0000956501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5833141at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="213"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000956501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30590" checksum="1DDDE4F32ECBCF11" modified="2015-12-09" version="1">MSLKISKNSKNRNEERKVQNNEKVTSESRRNRRRSRERSVTRLNRLGGREHHRDRVDSCIFSGESQVVTSSNKSNRHQVSSGFAQIGFGNRRLGFSRNSYTNGFENRSGQFFRGNMPRNGRGIRDNMEHRLPYGRTDRRSQRFEIRSEATTKENSEKPVMNLFDPCKVPTGKSYFTHDDRTNVPIRSRNMRRSNTRRMNFAPVGWRNAARAYDSDRNDDIGDASSRNRQDSQRRHGKSASDGIWKHDLFENDSEISKESRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPE5</accession>
    <name>A0A0N4UPE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10758</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001244">
        <property type="protein sequence ID" value="VDN60785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UPE5"/>
    <dbReference type="WBParaSite" id="DME_0000982801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000982801-mRNA-1"/>
        <property type="gene ID" value="DME_0000982801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000070">
        <property type="entry name" value="K+ channel tetramerization domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF133">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="211"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000982801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56316" checksum="671E255732EC604F" modified="2015-12-09" version="1">MSSNATQQHKKRLIPLRKTDAMSNAERCNANIIDEICNNGSDCFQVIPPDGRDPDGTPLFLRLNIGGTPYLLLIQALLKAESSGFLSKFVQLSHKARLKVADAYISNEDSYFFQRSASAFDAVFQYYATGVIHRPPEICPAAFLAELEFWRISYKYVGSCCADIVPREKSEEKEEEKVDNKAFDNLIFGQIRRRMWTFLENPGSSVQAKSFELSSTLFVAISVMGLSFGTVPDFQVVTQYLPSHNETVIFPNGTVKMVEKIEEIRVEHPAFVFTERICIAFFTVEYCLRLFAAPRKFRFALKPLNLVDLMAIVPFYLELLLTFFGVDDKKLRDLRWAFLVVRILRVLRVIRIIKLGRFSSGLQTFAMTLQRSQKQLQMMTIVLLTGVVFFSTMIYFLEKDEDGTPFTSIPAAYWWCIVTMTTVGYGDAVPATTMGKIIASAAIMCGVLVLALPITIIVDNFIKVAQDEQQSEQQKMEQLKQEQTIQSILKRDNDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPL4</accession>
    <name>A0A0N4UPL4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3463</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000136">
        <property type="protein sequence ID" value="VDN53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPL4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPL4"/>
    <dbReference type="WBParaSite" id="DME_0000990601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000990601-mRNA-1"/>
        <property type="gene ID" value="DME_0000990601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070446at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01268">
        <property type="entry name" value="PTB_Numb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000486">
        <property type="entry name" value="Numb-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF2">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000990601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="639" mass="70906" checksum="FCB291DBEBBE72D0" modified="2015-12-09" version="1">MLSYDVWANIFLEPITLSLNKSECVFKDEKNFRNIIHRGMDRIRRSFRESFRWKTTRDQLGRDLPREQSPANSAQPSGSGAPGMNADDKAELWQPDEAAVRSGTCSFNVKYLGCIEVFESRGMQVCEGALKLLRNQRRKPVKSILYVSGDGLRVVDQENNRGLIVDQTIEKVRVLVSFCAPDRNHEKGFAYICRDGTSRRWMCHGFLAIKETGERLSHAVGCAFAVCLERKKKRDAEAISAVHAAAGLQPIDTALRNRQNIFEGQKKFSGANSTYLTKGQNSAYGSFRRQLSITERLQDPQSAIVQEPPSRVAEHNDLRISAKPRPLANPLLFERHGSLRAPDSSTAAATAFRRQFSLRSYSDSPSKSYRTACCFNQSDAIAEGEEETSSQNLGDMSNKVESLTLISKINDESLDNIANEKYSGRSKADEWLEQTFRSSLSVNSPLKNFAETPRTDFCRAGPPPSQPPPPLPPAYVLATSRPQRQELLPVVESVKFSSDYSKYELPPITEAFSSVTEVNVQSPAVQAMDVFGQPIFNPVSQFSSANSCNSRMFNGKNCTISGCSSSGSTLENSFSNCSHVNIETSCIKQTGSVSSSNQEGYDPFNVKWSQMAIASSISFNQTSVKSTNPFHCELNTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPV4</accession>
    <name>A0A0N4UPV4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nmad5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3546</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000148">
        <property type="protein sequence ID" value="VDN53573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPV4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPV4"/>
    <dbReference type="WBParaSite" id="DME_0001001101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001001101-mRNA-1"/>
        <property type="gene ID" value="DME_0001001101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001001101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27577" checksum="5BC9ED828B7C6AB1" modified="2015-12-09" version="1">MFVEKNMCNAEKYAQMLPMFGIGKNSSDSYSVRTLSADAAYENQSLVCEQNTPVIQPNAGSILIYDCRAFANSNKSLKDIRASFRCDGYRYGKTHGTKAYGSAGNKIKRACRFLFGESEIGCKDFARYEITLWDDDCGLVLFHYVGDDEKARQVDRHKSDQELQFAVREYVKNQPASISSFRYSSPTQLRVSIAANEPRTYEEFLSDFQKMKTVLRHHERRIRLLEDELADRKLVDTYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPZ2</accession>
    <name>A0A0N4UPZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10833</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001254">
        <property type="protein sequence ID" value="VDN60860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPZ2"/>
    <dbReference type="WBParaSite" id="DME_0001005401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001005401-mRNA-1"/>
        <property type="gene ID" value="DME_0001005401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001005401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13051" checksum="F474610A326A104B" modified="2015-12-09" version="1">MLPLRPSVHPQLCRNRDDLVGNEIFKNGDNPGDIAATLVAQANPGANYLVSQFCENVTLKSLALRECAFCCVFCCKTKHFDCSNEDAHILVDSARCAWSLSRPRRALNDMTPWEPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ24</accession>
    <name>A0A0N4UQ24_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Miff domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000156">
        <property type="protein sequence ID" value="VDN53637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ24"/>
    <dbReference type="WBParaSite" id="DME_0001008801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001008801-mRNA-1"/>
        <property type="gene ID" value="DME_0001008801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001008801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20629" checksum="0EDA9A797E0E03EE" modified="2015-12-09" version="1">MVLPVGAPEHTLIRSSQPNVNLTRTDGNRVISALRSDTKVLSTHISDRGGYSQSQPLQQLMLPSSVMMNRYHQGRHTEMTLELGGQSGFFGTGLLRVKQQRTRAKSVQLGNLENLFNADMIESLDYEYDTKENEPLIRQRAGINGSARSRLSARMSPFKEKCLPLTKEETLELLLLLNETGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ74</accession>
    <name>A0A0N4UQ74_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10842</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001256">
        <property type="protein sequence ID" value="VDN60869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ74"/>
    <dbReference type="WBParaSite" id="DME_0001014701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001014701-mRNA-1"/>
        <property type="gene ID" value="DME_0001014701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5797421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001014701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43776" checksum="871154B4A28BB980" modified="2016-06-08" version="3">MNITSKNAINVFTTTTLGNHFPPEYCFIIDTDRLSERFWLVTVLGSTLSAISIIENLFLLVLFARSRQHRNSPSFYLLILALSDIFISGTYIMIMSVKVLYQYAEWVALKRIWIIYLVPMMTMSHVAITTSSFLIVFATAERFFAVISYRNVEFLQNNRKLIALLAIIIGLVTKSTLLFEIKAVYNPECTGTLNEYKLELTDLVIHNAHYKLWRFWFRNIVTILFPFFILMYLNARIVNQLRENVNIGENIADNMKQRKARIRAATRTLVLVVCTYLLANMLNVIITIWEHTDATSLFTGKKVIFILDYSFFSFLDFYIISVDAVSLLTIVACALRLPIYASCQPVLRREMIIMIKRLLKNQELEERQIPLLEKNIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ85</accession>
    <name>A0A0N4UQ85_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS3676</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000166">
        <property type="protein sequence ID" value="VDN53703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ85"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ85"/>
    <dbReference type="WBParaSite" id="DME_0001016001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001016001-mRNA-1"/>
        <property type="gene ID" value="DME_0001016001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072702">
        <property type="term" value="P:response to methyl methanesulfonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="128"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN53703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0001016001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29330" checksum="0D35EC36F798BE2E" modified="2016-06-08" version="2">MFEAKLGNAALLKKIIDSIKDLVNDAPFDCSENAVCLQAMDSSHVALVSLKLEVGLFESYRCDRTINLGLSLASMAKALKCANNDDTCMIRYEESDGDSIVFIFEDVKREKKQEITVKMMDIDSEHLGIPDQEYSAVITMPSLEFQKTCRDLALFSDSLLITVTKSGVVFTGKGDTGSSVVTYSPTSGVDDEKEAVLIDVKEPVNINFSIKYMNHFTKATSLSPKVKLSLCNDIPIVVEYELEEHGHLRFYLAPKIDDDEGMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQD1</accession>
    <name>A0A0N4UQD1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3720</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000174">
        <property type="protein sequence ID" value="VDN53747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQD1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQD1"/>
    <dbReference type="WBParaSite" id="DME_0001021301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001021301-mRNA-1"/>
        <property type="gene ID" value="DME_0001021301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="9">
        <location>
            <begin position="190"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="695"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001021301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="943" mass="108226" checksum="0671855FCDA78A46" modified="2015-12-09" version="1">MIYGFVDNLIEMGYYREDIHLDKVHFTQNLSSVLSDPKQSRYETQVFFTRHWGDSFIVKNNIAASPLIPSITAEHFKNYLNTIANKRQNCLKVKNNFWLTYNRYEQNRTDVDDVPTILLNPYFSLADPETFDSIFLEPKQSEPDCLLVNGTSAETSQLSICLHDRTDERISQLIEPFRTEDGRRFRSYHTLQQRLESYHDLVDSRLNNQLASKSNAFWKTVVSYSGLHSELADAINKILVVRKSLQLVNEKICGGMMKIVELYKNRQRNEQLLHKLQDMACLRAAQTTVQMLLNQSDFPKALECIETAQDVLASDLRGVLCFRHLNSQLQELRKMIDKVLHEEFIALITKELGRSCETEADASYQGVSLALYSLIFFSSSAVEIQILKSHVIINDADRAAAGLDSSSGNLNIQICSLNFDEWFSAFDHVLRVSYYKCRRMLSLQKLLIENIDRYQKLNKPITVEPNCDSNDDAKILDVSNMFDDIDEIDTKIGEIPLNLQCTTDGRNSQPDNLSETSNVLDSPEESKKFIRSAISTPLAILSMPCRNLSQVRQSLNLLAEYTANCAEERICKLLVARSKDGSLECLSVAEFQKILYVVNDFIEKCRSLVNANESYYSPLRLCIVQRSSSFIKKFHEDRRIKLGIILDSENWRANDVPEHFVRLVNEALRIGKLRDIPNFGDQQPQSKQQLIINGENFVVVSTALILLQMMGQYCDILEVLPDFAIDLLMCLVELLKNYNSRSCQLILGAGALQLIGLKSISVRHLALSSRSLQLILLFIPYVKAQFNSYLDASRSNHFRYLDQIMKDYSNHIQEILNKLIGVIDHHLVVQLQSWEVKAVVPSPAFMQIFKHLKRFYNGLVGVMPEAVIKELFLRVHENFKRNLKEYLDEVGITPHDSLTYGLVSQEYLYYLKSLQSLGCCCDFKDESISEALYGHKIEKYRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQH3</accession>
    <name>A0A0N4UQH3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS3758</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000180">
        <property type="protein sequence ID" value="VDN53785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQH3"/>
    <dbReference type="STRING" id="318479.A0A0N4UQH3"/>
    <dbReference type="WBParaSite" id="DME_0001026001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001026001-mRNA-1"/>
        <property type="gene ID" value="DME_0001026001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase mitochondrial 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="294"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN53785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0001026001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="679" mass="78588" checksum="D859647BF1403F5A" modified="2015-12-09" version="1">MSPWPDFIEERNALFEKLMNDYKAEIAAKISEPISIKLPDGKIFEGKSWRTTPMEIAEKISAGLANTIVVAKVNNEVWDLDRPFEDSATLELLKFENDEAKQVFWHSSAHVLGEAMERYCAGHLCYGPPISDGFYYDMFKEGDAISPNEFPNLDQIAKCIVKDKQPFERLLVSKENLLKMFRYNKFKVTVRIINEKIDTPYATVYRCGPLIDLCRGPHVRHTGKIKAISFTKTSCSHWEGKVDAESLIRVYGISFPDSKQLKEWHKLQEEAAKRDHRKIGRDQELFFFHPMSPGSAFWYPKGTHIFNTLCNFIRKEYRKRGFTEVITPNMFNCKLWQQSGHWDHYSDNLFKIEVEKDIFGLKPMNCPGHCLMYSHMPRAYNDLPIRYADFGVLHRNEVSGALSGLTRVRRFQQDDAHIFCRPDQIGEEIQSCIDFLTYAYVKVFGFSFKLNLSTRPEEGYLGDIATWDSAESELKKALDSSGHSWELNPGDGAFYGPKIDITIKDALRRFHQCATIQLDFQLPQRFDLSYFDENGFRQKPVMIHRALLGSVERMTAILTENYGGKWPFWLSPRQAKIVLVHNSLVEYARMVQKKIYEAGFEVELDEDSSDTLNKQIRNAQLAQFNFILVIGPKESENGTVNVRTRDNAVRGEVKLDDLIRKFKRFQEEFVKDTESADEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQM7</accession>
    <name>A0A0N4UQM7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">maleylacetoacetate isomerase</fullName>
            <ecNumber evidence="5">5.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3816</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000192">
        <property type="protein sequence ID" value="VDN53843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQM7"/>
    <dbReference type="STRING" id="318479.A0A0N4UQM7"/>
    <dbReference type="WBParaSite" id="DME_0001032101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001032101-mRNA-1"/>
        <property type="gene ID" value="DME_0001032101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001032101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21790" checksum="7E9EF5ABBB6B7279" modified="2015-12-09" version="1">MSKIPVLYSYWRSSCSWRVRIDFLKINPFGKVPAFVHNDVIFVESLAILEYLEENFSDRSPLLPKDSTERAKVRAIIIADIQPIQNIGVLKYINDNFDGQEVSKIWAKRWIESGFQKLEKMLHMTAGSYCFGDSITLADVCLVPQVYNAQRFGVNLENFPTIKRINEALLTVPAIMKSHPDRQPDAQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQN9</accession>
    <name>A0A0N4UQN9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10873</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001263">
        <property type="protein sequence ID" value="VDN60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQN9"/>
    <dbReference type="STRING" id="318479.A0A0N4UQN9"/>
    <dbReference type="WBParaSite" id="DME_0001033501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001033501-mRNA-1"/>
        <property type="gene ID" value="DME_0001033501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872295at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF22">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001033501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35304" checksum="A0E9FB23E0AAF377" modified="2015-12-09" version="1">MVKVSDKSIGDEDKFETNYEQSNFDKIISTLLCRSDKAKEKLEAKPVSFFRLFRYASFSDKLLVGLAIFLAILSGIGQPMVVVIAGLFTNVLLLTDQFIGNDEFWYDAFVYVYVYAAVGIAMAIITIVQYICFKNVSLNVARNIRSIYMKSLLHQNAEWYDRRKAGMITSQLNENIDKIKDGIGDKVGLILRGLVMFITSLVVGFIYEWRITLITIAMGPLSAALMSLMARIVDRITFKQMDANGRSTSIVEECIMNVRTVAACNGQQMMLDKYSASLDVARRFTLRICSYLGFFDGIFFLIMYLFLALGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQX2</accession>
    <name>A0A0N4UQX2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10903</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001271">
        <property type="protein sequence ID" value="VDN60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQX2"/>
    <dbReference type="WBParaSite" id="DME_0001043501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001043501-mRNA-1"/>
        <property type="gene ID" value="DME_0001043501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001043501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11970" checksum="B4FE0439D7A81E8B" modified="2015-12-09" version="1">MCRTPYLSRIAFEFCPHTCGLCDLPGAGGECPDSIDGCESLRGFCQLDSIRNICQRSCFSKACLQNITISQSSGCTDAHVDCPSYRHLCDIGDYGTVMRTQCRRTCGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URH7</accession>
    <name>A0A0N4URH7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10943</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001289">
        <property type="protein sequence ID" value="VDN60970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URH7"/>
    <dbReference type="WBParaSite" id="DME_0001065801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001065801-mRNA-1"/>
        <property type="gene ID" value="DME_0001065801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
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        <property type="entry name" value="ShK"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720551" evidence="2">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001065801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17908" checksum="78646880A12C198A" modified="2015-12-09" version="1">MLFLLIVLAFLCEIANGADEDIKVCSISVPVPGQNNAVVRPSVPVEYCQDRDAAACFEIFKPMGNDVLANNRMPNENYKVLDKCQQEPYIMLARQMCPWMCATCCMTKEYNCENATTLPSPTATCRDERQNCAAFRATNNCGGVFRTTMIQQCARTCGYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URT5</accession>
    <name>A0A0N4URT5_DRAME</name>
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        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000354">
        <property type="protein sequence ID" value="VDN54197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URT5"/>
    <dbReference type="WBParaSite" id="DME_0001076701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001076701-mRNA-1"/>
        <property type="gene ID" value="DME_0001076701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001076701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9143" checksum="1041F67E36DF33D3" modified="2015-12-09" version="1">MYFIYLPYLFFISSAKAGNDKDINVCNRAVPAPPVAPGAVPAVPPPPAFVQRPTVDPNLCADLDPACSAIFAVEDQDTLQNQRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URW3</accession>
    <name>A0A0N4URW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4196</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000392">
        <property type="protein sequence ID" value="VDN54223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URW3"/>
    <dbReference type="WBParaSite" id="DME_0001079501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001079501-mRNA-1"/>
        <property type="gene ID" value="DME_0001079501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162717" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001079501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12901" checksum="2215010D066FAA29" modified="2015-12-09" version="1">MLFHFLSIISLVRGAKGGEDVPIPHCNKQVTVGRDVRQRPTVDPQLCARRDTPACDAIFDIKGRPVDADGIAATIQSHSNPNVDYEEFQEIKMRQLRDQLAETNKDVLIIDPYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URY9</accession>
    <name>A0A0N4URY9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS4220</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000423">
        <property type="protein sequence ID" value="VDN54247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URY9"/>
    <dbReference type="STRING" id="318479.A0A0N4URY9"/>
    <dbReference type="WBParaSite" id="DME_0001082101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001082101-mRNA-1"/>
        <property type="gene ID" value="DME_0001082101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874796at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001082101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6810" checksum="39C1B172A5C66E7C" modified="2015-12-09" version="1">MKIALIGCAIWAHHIYTVGKNSCAYFAATIVIAVPIGAKVFTWLTTFMRKRSSFSGEKNSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US73</accession>
    <name>A0A0N4US73_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4299</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000640">
        <property type="protein sequence ID" value="VDN54326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US73"/>
    <dbReference type="WBParaSite" id="DME_0001090501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001090501-mRNA-1"/>
        <property type="gene ID" value="DME_0001090501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001090501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27512" checksum="05AD99B3744AE026" modified="2015-12-09" version="1">MVQISDKNYDQRTIVKSEKVEFSTLMKEDWNKTRNFGCAKKLCFNKFSRIDLTICFYKLREAPAKSRYAMKSSSGQNLPLQLKYDLENATFSSEQEPSTNTSTQNNTVEMSTLDVNSSASQFESFDSDSSESESVEMETVSTYQPTTMETVSTHETTRLADTMQATLGCSKSNITVKVQERVLARHKTYRSTLEYVIAKMHGYLPDERRELKWNCSLEESAQLWANDCSWAHSSAALENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2R1</accession>
    <name>A0A158Q2R1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5014</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2R1"/>
    <dbReference type="STRING" id="318479.A0A158Q2R1"/>
    <dbReference type="WBParaSite" id="DME_0000065401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000065401-mRNA-1"/>
        <property type="gene ID" value="DME_0000065401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000112">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="25"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000065401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44909" checksum="2C241828C86467E8" modified="2016-06-08" version="1">MGANASSQLEKEINSDHLLSNEHFYGLVNFGNTCYCNSVIQALYFCKPFREKILQYKQQLKKSGNQKENLLTCLADLFHNIATQKRRVGTIAPKRFITKLKKENDIFDNYMQQDAHEFLNYLLNTISETLSEEKKNEKLSRANGTIKKGLAAVNPTTNQDNRPHCQPSGSKCESTWIHDIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNVSITHCLRVFSNMETLKGDQKYYCENCCSKQEAQKRMRIKKLPQMLALHLKRFKYVEQLNRYTKLSYRVLFPLELRLFNVSDDAVNRDRLYDLCAVVVHCGSTPNRGHYITVVKSNAFWLLFDDDIVDKIDPVTMEDFFGLSECGVQKNSESAYILFYEAQDVAISNDAKAHTTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2S9</accession>
    <name>A0A158Q2S9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5123</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2S9"/>
    <dbReference type="STRING" id="318479.A0A158Q2S9"/>
    <dbReference type="WBParaSite" id="DME_0000076301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000076301-mRNA-1"/>
        <property type="gene ID" value="DME_0000076301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="110"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000076301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28134" checksum="2FD475186978DC2E" modified="2016-06-08" version="1">MLNISSNIQPTCSAMLRVIPVVNSYIQSIRKMRRRPPKPGKPPIVPPSQKVLYTVVHVPWMEPSAVKELLWRRHVYNNAILSLRRIFREEIAQKQTGGLADLKIQEASELNELIAANEKRNQEMAKLRNEREIKRMKEVEMEVLRFIEEELNKREKSVKLATKEVVEMIEKSREFVTLDNLDCKLHEALENPVVYDFAIDLEGKRIYAPVPNKYLEGKPVLQKGRMYDVTLGFPQEAVQKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q341</accession>
    <name>A0A158Q341_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5944</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q341"/>
    <dbReference type="STRING" id="318479.A0A158Q341"/>
    <dbReference type="WBParaSite" id="DME_0000158401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000158401-mRNA-1"/>
        <property type="gene ID" value="DME_0000158401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="238"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000158401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44894" checksum="928A27B80CC74910" modified="2016-06-08" version="1">MADECGVLSISEQLRLAKDMGYTDEDIMNAVSMNCDKDGSYRPFSSTNAMIDMLTRVQKACSSPKHQKKTCIFADNEYGPGRSSQSRNPCSTVRRTTSFHNSSPLRPFDHFDDLSASSLHELRVRPSAPFQLQRLLDAFDKERKNFSEESKRSVQMLEDRCRLFADNQVLWHNRLFDKECEIKALKAQIHDHSSLSEHLKLTKAKLDAELLENKSKTDQIRVLTEQAEVVKKQHDSEIREKEKMISDLLIKLNSVEETNKSLKEINEILQKEIEELKQILVKKQSDIEKCNNYLDEIRKAEQLVEQIRLERDEVMSLLNKIPTCVICLDKRPQMLYMPCSHFICCETCGSRFEHCPTCRQKICGKITSTASSVSSCLTSSKRDRANPFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q381</accession>
    <name>A0A158Q381_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6206</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q381"/>
    <dbReference type="STRING" id="318479.A0A158Q381"/>
    <dbReference type="WBParaSite" id="DME_0000184601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000184601-mRNA-1"/>
        <property type="gene ID" value="DME_0000184601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF555">
        <property type="entry name" value="TETRASPANIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000184601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="49032" checksum="CA0ADE6844E7988B" modified="2016-06-08" version="1">MLLYFYTTNFEHSSLGQLFPSSTTAFECKMKEMNQCSQIILLLYTLFFWVSGFTLIFMAIWLLLDPRRNYVLDLVDFSEDDPLLKVTTYVALFTGIVSLLIGFVGCCGAVKRSLYLMISVRFFLFCFVIFNGWKYEKNLSLLIPCLPGLWPCHLSGETKTLLTIEISRRTYLIKELIMFEGDYLQIYLTNLTHDRYNRDYWVTPLLDTIQYYISSTSLDIILRKMIQEDYGIRLHDRYHARITSFIDKLQFYEQCCGAKNFTDWNRSRWLTSIKISSSMQEKDIPYSFTLNAVPTTCCVQLNDATALNPVARSLARCQQQNANRTWRYVSQQCCGGFGGPHDYYDSFWYKTNTLRGTRSFVPKSCCKQSQYARAWNIKPVDAMCTTYMYYSHAFNSSVNIEAIFNFLKICQVFLTYCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3H4</accession>
    <name>A0A158Q3H4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS6767</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3H4"/>
    <dbReference type="STRING" id="318479.A0A158Q3H4"/>
    <dbReference type="WBParaSite" id="DME_0000240701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000240701-mRNA-1"/>
        <property type="gene ID" value="DME_0000240701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000503">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="135"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="492"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="582"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="674"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="767"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="865"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="960"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1051"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1135"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1223"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1275"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1367"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1459"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1604"/>
            <end position="1687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN56794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000240701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1691" mass="186279" checksum="9EFEBC02515D09E5" modified="2016-06-08" version="1">MFLNDHQQLHIESAAEEDAGRYSCVAENKPGRVEKDMIVAVLKPPEMEDYERLLESPENDSLTLTCPINDPSVEMQWLKNGVPITTSSKLQLSASRAKLHLMNSQVSDSGRYTCRAWNDAGEDVSNMDVLVLIPPKIVGPSFRSINSILNQTVHIECKITGTPQPKVFWSFDGRKLFPSERTQIRNNGTVLVLSEVQTNQEGRYSCIATNKVGRAEADIFLQVTVPPLITTPADELKVIKGQGQTIRCEVSGSPSPKVEWLKNGQKFDSAMIQRSSNLHYIHLREAQVKDAGRYTCIATNRAGEHRITIQLHVLVPPAIFEGDRVLQVKEKTMLTVDCQANGIPAPQISWKRDGVPVDTVEGSRLVIKSPKANDAGRFTCEARNEAGIATADFEIDVFVKPQFRDLISEIRVLEGERARLECKADGHPEPSIAWLRGGRLLEDMKNFILSPRGETLMILKAKRTDGGSYSCVAKNYAGKSEASFTVIVLNRPHIEELIDQNPKVVLNNDLVLHCPVLGNPKPKVEWFLNGVLVKGDRYTIIDDTDLKISSSQQTDSGRYSCRAKNEAGTLNTDYVVEIIGPPKFHRGGDANYEAVLGGTITMNCAVDAEPTPEIVWYRSDTAIYLSDNIRISDDGQQITIRGIQISDGGKYTCKAKNEAGSADIDLNLKILVPPNIDKSNIIGNPLAIAGRSIYLECPVTGIPQPDITWLKDGLVITTSEHFSLDQNNQTFGIKIVDIDDAGRYQCIAENRGGTAEQEFKLEVLVPPELETTEPQKHIKHEKDSLTLWCPVRYTPDSVSLPDILWYKDGRPIDTRSSSNIKITSEGQRLQLIKTTLTDAGNYSCVALNRAGETSLTFHVEILSMPKIDSSSQIAQPHVIIGKPVTIWCKVTGYPMPIIKWLKDGKEQNVMNRADIQVLENGQGLMILETKEEHAGIWICEAENNAGKNQLDITLDVWTPPVVAISPNDTLRALDTPITLYCEATGNPEPSLSWSKEGQPLISSVEGARISLKGKRLDIPRLRQSHVGEYSCIATNEAGRAEAVVHIDVLVPPIINRDNIEMSPRLPTGQTLTLLCDATGKPKPTIQWYANDTLIVNGKNNISNISLPDHGIYKCSASNIAGYDELLYTVSIVQSPWIGNGGTVQTVEGDITKMICDAYGEPPPVVTWQRNGIRVESGVRYIIEDKLLKILDTRTSDSGIYVCIATNEAGTSQQAFTLEVLVVPRITMTSPNDSVVPVGEPFSLKCGARGYPVPDIDWMVNDKLIDAENEGFSVGPPVVTKRGIKIINATEGDASLLVCEVEGLTPQIRWYKDGSPLSIESNMEFNEDRTELKIHASRLHDEGTYDCIAMNPAGNATQNLLLYVGVPPRITEKPRRIIVKSGQTAKLWCEAVGIPKPHITWLKDDQALEQAILDEYSDILKSVAVFPNITSEDAGVYTCKAENWAGTSYKDVDLVVLIPPTISPERLNVTGEIYDTVILPCNASGIPEPVVSWIKMPNVNIVSNGEKYQILGSSLAIRNIAAEDDGFYHCVAKSNAGQAIGSRRLIVIVRTTYIAARGDMPESDHNLLPWKQEYQDLPVNGTDGTLIRCLPGVREPRHTISGIAPRFIHTPQSQSVPIGSIVDLYCSAVGSPIPEIRWRWNNKTIDEETNTNGFSKLRLVLDNHEDSGEYACVADNAMGSITASVQITIIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3Q5</accession>
    <name>A0A158Q3Q5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WASH complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3Q5"/>
    <dbReference type="STRING" id="318479.A0A158Q3Q5"/>
    <dbReference type="WBParaSite" id="DME_0000291601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000291601-mRNA-1"/>
        <property type="gene ID" value="DME_0000291601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="565118at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000291601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1192" mass="136708" checksum="E049B33B81E3D6D1" modified="2016-06-08" version="1">MEEENNLHDIIENGHLILAEIYRLSNSIPIDFVEPTQSKFVSLLIDFSYFDDLSIFDRLNNSDEHAQLEDEFFFTFDRIITQFGSLFDALGQFFARIIELSEDNVFNETSISMRLSKSTHHYYRLQAESLYIAGVILLCLVTKITSGARQRLFIAHYRSNPSNSDHSDLLVDILKTEPTDFDGKLPVKQCFAETMVSLLRNDTLFISENFSKNDYFTNDSFFISRISRIQRSVLTICLFFAPTILHSNSSVMRQIVDAYFADDWVVPLHLGMILNIVNAWEQFKAANSALQQIITIQSVKQIASEHLLKLKEIEFSSAAKISVTNSVYNANTIAIANKHLRWIILHSCIFTIQCSFTMFSSLPPFVKKNSRNVLLLFAMPFAVNWDYLWMIFSKLSSFEHSFKEAYRNSISNKKSSINTLKTEICQHISQIASFFATDIPLQKMKKNTKLSEWFLLVEKKIEELNMEEPETLSIIAHVKKRIEQVSEFHDLISNVAINQHLQRISTLLNDVSHFCTLSEQFLSDVDVASDFSYAWTIIEQWRLEMERMIEKDPLPIRSLFIKIASSIAIAINSVVTPARISAISLCYSRQLEQLLRKILQAVPRSLFILLYQITNLLDPPITSAINKNEMRQFADPDRRYKLAEITYAVSTLSLGISTMQLTCLGSIRIDPSALFLDGIRSELVFEITNAFHAELSSSQDLNTILINLNQRIERLRKAFIYICEHIGLNGSLIWHNETTRIIGYMIEKESNAFLRHVSSLFLSSVGYNFGCLESEVGNAPDYRVKSSYQSISVPIPCTSPILGSATPIHRMFSLFLAASDPRSVKELSSLLFHDFLYSGPRCKFFFCFRMTFYVNSTRMWYDVKTKKLTFSNEFFSEFQAKALSPMALWATNHLACFSLVKHLNELCSMCAKIVVPTLSDIFRELKITEVAPSSSKIFDNVLIKFTPHSTQFGTTISKVCLISNFPNWLNIVWLVQLAVKIRPLCQKNHFGLEIAGYNYYWISFSVTNILYYTIGQLQLLRLGINEVIKKSIIQRVPHMYSALSTFNKSVIADLQMDNELLKADVLKELAELLQRFSIVDPLKEFFIRREAPKFINEILFASFLFFVSKLNAPKRADFIDISAFTVGISCVLTQFQIFDEFFAICNDFLLSIVLNNSNRGNKIAPFIQSLTMIGRYCSFNEKATPDFVLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q465</accession>
    <name>A0A158Q465_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS466</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q465"/>
    <dbReference type="WBParaSite" id="DME_0000410201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000410201-mRNA-1"/>
        <property type="gene ID" value="DME_0000410201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF4">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000410201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34306" checksum="FB2488BE2CB15443" modified="2016-06-08" version="1">MSVEWKRLCLTTAGCHESRFRIIMFNEISNIQLIKSWTIGDGQFQDKPRSFISSWENGTPNAITISSEVAGIDPTYKFPRICDLSKNFTMYDQSKNNQISTRMRLDHQLIMEDENGKMMIELKGRCFNVTLALTKFEERCPWCSVSNDVTVIENQYAEDDQKFDFIRTFLTDDHWLFGAIIILAFVATISCIAFACLLKAFLQQKQIYSSKKSRFVGCSHNFAVIESPCTSENSSKYEIPWDQKYRILPRWTSIQSDETVSSPVDSSTSSSSQYSKTMLSVNEYVSPGILNSTHHENCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4G4</accession>
    <name>A0A158Q4G4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8681</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4G4"/>
    <dbReference type="STRING" id="318479.A0A158Q4G4"/>
    <dbReference type="WBParaSite" id="DME_0000479801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000479801-mRNA-1"/>
        <property type="gene ID" value="DME_0000479801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000479801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66684" checksum="B6210A9168977BDC" modified="2016-06-08" version="1">MFPNIEEIILSNNRLGAIDWEAFRLYKLRRLILSYNSLTAINEHMLRFTPNLEVLDLSHNYLIHVQSSNFFSAQKLRSINLSYNHIKRFDYDSFSPLYQLQTLDLSYNEFINVPAGDLRQLVGLRTLNLSGNAFDRILDGDFVHPVLQELVLSNCHSLRLIESNAFFGLPYLTLIDLSWASSLVYISPQAFANNTLLYRIILTHTQLETIPKHLYTVPKIAINDNPFQCGCVAKMVKKFQDHIIDVANASCFMLEGTRKRLSESIEKIDEPCRPEPIVPFGEVLSATVGQYFSLYCASRNFDDIVLWRFPNGTEIIANNATQLSPSKPANIYDLFPLAVNDPQNINSFSQTNQPRIFITKERIRFDVILMDDEGDYRCSLFLQIGSHYVALAWNGSLAIKASYRINLYLTVKDLSSAAGRSIQLSLHNPWLSYSVMRLKPNQNYTFCLVYILLESGFSKTIYETCTQETTAPSLSILNSLTLTTLLAFFIIMLLFCSLFFIKSLYVRLHIWQQQKYRSRMNQSISGQSFISTTSSTSRDASITYENQLSVNQSVPLYRFRISNPNILEEVTAEDLSTTENNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5C4</accession>
    <name>A0A158Q5C4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SNF-related serine/threonine-protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">SNF1-related kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS9792</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5C4"/>
    <dbReference type="STRING" id="318479.A0A158Q5C4"/>
    <dbReference type="WBParaSite" id="DME_0000699301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000699301-mRNA-1"/>
        <property type="gene ID" value="DME_0000699301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000166">
        <property type="entry name" value="SNF-related serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDN59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000699301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63787" checksum="34D7A6229CE4572E" modified="2016-06-08" version="1">MAEGNVNRKTSLKINNTRIAGLYDLKQTIGRGHYAVVKLASHVFTGENVAVKVIDKNKMEPKMHSSLMQEVRCMKLVQHPNIVRLYEVIDTNTKLFLILELGDYDMYEFIMKNPDKGCPESVAQQYFCQIIKAIDYCHKLHVVHRDLKPENVVFFKKLGMVKLTDFGFSNQFTPGEQLATSCGSLAYSAPEILLGDAYDAPAVDVWSLGVILYMLLCGRLPFQETNDSETLTKILDCKYVLPDTLSNSARHLIFRMLVKDVNKRATLEEIMENPWVKAGERGLDEVLPLVGRNALSESAHSMIIEQMVAGGVATEERIFRFRDNEYSYISATYYLLAEKVLAAQREARAQEILSAERPPYNDPMDKRTDARLIIYLAVYQSDEIYRNSSPSVSMVAAPSESSEKISRQAIQELLDFSRLNIAGIHHRAASPDSRISSRSSSPHSSSGRTSPAVILRCNTFDLNTYVSKDGCVLSTPLTYSKVRMIRPRQAIVSPDMARRYEIRNSHNYSNRTRRSTSCSSSETSDEDITERRLSIIVSKICKRRGDDHDNDDDNSRGYFIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5H5</accession>
    <name>A0A158Q5H5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fasciclin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1744</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5H5"/>
    <dbReference type="STRING" id="318479.A0A158Q5H5"/>
    <dbReference type="WBParaSite" id="DME_0000738201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000738201-mRNA-1"/>
        <property type="gene ID" value="DME_0000738201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810603at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000058">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="180"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="347"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="495"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000738201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="684" mass="80339" checksum="039E3EA63D118108" modified="2016-06-08" version="1">MSNLLLIIIRVHFLFLILIKNVYLDLWTEMERMNDLQQWRSLCGRYAVAQAYMEDSNARITVFAPVNDVFTYNPDLRALNQKETLSHIVDTQIYEIGQGKKWDKQTLIRSTINSGFIYITQFENSPGNYSYFANNGMLCNHASNQWAIISGEQFLYKICTPIGHRPYPSTALSFIRDTDRSNFFERRYNNYELTELRDVLDRAPDIALAIFGASAWNGFHTFFLPTNEAFSKVIDRNRVDREVILAHVTGINRVLFTYPWLYDRGIHHYPSIRFSANIIEDNYKLRLSMRNITDRRTGRWDLYVVSEIYERYSQFRRGGVWAKILVPNIPVQNGVVHIVDNVLGIVSKTIDMLVMDNYRCTTLMRYINNIGQIVRNYFSATGGLVTFFAPYNEAFERIPEYIERRLLRDRIWLEQILKLHIVPAKELTSDEITNDTMVNTVDNRQYLYFIRGEWPRNNITYYVVGGGIRAAIIQDNVAATNGIVHYIERVLGVPYQSLFEILRNESRLQRSYEMLSNLQLQYTLNPYQVLTPLQNLTFFVPTNEAWDRVPSSLRFKMLDGNHWLALQFVFKRHIIQGQALMYVDLRERTYVMMNDEKVVIRRTGRYFELYWPRGNRVARLREGGEIAGINGFMHLIEDVLIYEPDLQAAAGYVDSSGFLILFSLIFLYIFDRNYLIILIYFVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5W2</accession>
    <name>A0A158Q5W2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10380</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001214">
        <property type="protein sequence ID" value="VDN60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5W2"/>
    <dbReference type="STRING" id="318479.A0A158Q5W2"/>
    <dbReference type="WBParaSite" id="DME_0000843601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000843601-mRNA-1"/>
        <property type="gene ID" value="DME_0000843601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09376">
        <property type="entry name" value="LIM2_Lhx3_Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000219">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000032">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049594">
        <property type="entry name" value="Lhx3/4-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000843601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32461" checksum="E2C83D50DF21E4B0" modified="2016-06-08" version="1">MCGKCESPIRDRFILKVLDQLFGTKCAKCEEGICPDTIVRRANEHVYHVECFQCVICKRELRTGEEFYLIPNDGRLVCKSDYEMAKNKESDVDSNTKRPRTTISAKSLETLKQAYQTSSKPARHIREQLAADTGLDMRVVQVWFQNRRAKEKRLKKDAGRRWAAYGMNKALDSDSASPDGSLCQSPLFGTSGYVDTSIDGDGQSDVGYGSNLFFYEWFFYNGIGIFLKNLCFTDIDNNFGRTPDGNLAPAGALLGLEPTTMQSELQNSLFIEASPGIVIDHSVSHQYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Z4</accession>
    <name>A0A158Q5Z4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2579</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Z4"/>
    <dbReference type="STRING" id="318479.A0A158Q5Z4"/>
    <dbReference type="WBParaSite" id="DME_0000866401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000866401-mRNA-1"/>
        <property type="gene ID" value="DME_0000866401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000866401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25463" checksum="119172E1B6E4F810" modified="2016-06-08" version="1">MPVYYAPDLSKASYLSFIKILCTWKGSLWKSVYMEAVVWLALYIILSLVYRIGLSDESKKIFVKVVRHCHDHEGWIPVTFMLGAFVTIVLQRWWSVVSNIGFIDNLALIITNYTRGSDDRTIMFKRNMIRYMCLVQAMVYRAISPKVKRKYPTLDSLVQAGYLEPNEVCMISENNFYQSVSWALALARLARDENIIKSDQALQDIFQVLHKTLILNYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P8K9</accession>
    <name>A0A3P7P8K9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="4">EF-Ts</shortName>
            <shortName evidence="4">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P8K9"/>
    <dbReference type="STRING" id="318479.A0A3P7P8K9"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25025">
        <property type="entry name" value="EF-Ts_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="5">
        <location>
            <begin position="99"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="302" mass="34645" checksum="8ECC509B057849E0" modified="2019-02-13" version="1">MFENNSIKYISSTSRQRSMHSRYIWKLLKFALKTLRKRTGYSYVNCRKALLEFGANRLEDAEKWLHNLAVKEGWMKATKLSDRKAINGLISIAIEDNKAVLVEVNCETDFVARSEIFKSLESFVLPERLLPIKIELDKLYSENKKMTINDLLANTVGKIGENIVLKKVYGIVADPDIMLSGYTHPKEGTKEVNMGRFASIVGLRRFAPGDFPLKTIGEQICQHIVGMKYVYLFSLHFFRREKQEASQASHLEEIDTTTQLDEKETSLLRQSFMLCPSQSVYEYVNSHGAKIIDFVRAELGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PGC3</accession>
    <name>A0A3P7PGC3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4997</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PGC3"/>
    <dbReference type="STRING" id="318479.A0A3P7PGC3"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="371" mass="42277" checksum="6385F5829C83F327" modified="2019-02-13" version="1">MRMSSFPVQHWNFGIGPITCHAWNKDRTCIAVSPSSNEIHIFHWEQGQWKLTHLLKEHDLPVTGLDWAPNTNRIVSCSQDKSAYVWTFDGTNWKPELVLVRINRAATCVKWSPLENKFAVGSSEKLVSVCYYGRENDWWISKQIKKPLRSTVTCIDWHPDNIILAVGACDMKTRVFSAYVKEVDEKPTPNPWGMKMPFGTLLCEVKNLGWVHHVAFSPSGCRLIYVDHGSSICLIDTNHSLDEPIVLNTPFLPFTSVQWITENSVIAAVREFQGHDSTPMLFMYTNETLKFVTKLDIPSEQKSTNTNSAMQKFRNIDRNAASEALNIKLKTLHQNAIMQILPHSGRQQNIQKFTTCGIDGLIALWDIKVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q4C9</accession>
    <name>A0A3P7Q4C9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q4C9"/>
    <dbReference type="OrthoDB" id="5799881at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="72" mass="8015" checksum="B34A77E8742B0301" modified="2019-02-13" version="1">MISEALRVVLGQAAPNYTLGQFDPSTLKGSIIVAEKDLHLIWAAISIYGQHFGYSVALHINSVHKFLLKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q4F1</accession>
    <name>A0A3P7Q4F1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q4F1"/>
    <dbReference type="STRING" id="318479.A0A3P7Q4F1"/>
    <dbReference type="OrthoDB" id="5828479at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="316" mass="36012" checksum="7F40BB4D6B7E2204" modified="2019-02-13" version="1">MNQKRRGFQSHSGSQERVRTHLFFSSQAEHHTAKRKRRTHNKLHQLMHRKDEMVQTGPIEFEPDLWSGNQRIIHFGPLAQRDPYFYYYPKGWDILYPAHFGFFPYRATKFRGSSSAVCMGAFGGFFCIGGALMIFLGHFVISGPLPWFHNIYLRDPIQIAGPILFLFGVFLILIAAICSICSLKKPDGFYEKPPYQPLPPPAYPVLENKYIQSAVFNPQSEMKLYPPVMPGCSTLSLHGRSPSVYLGNPYNTLRAVSINRYHFILLITLTIAKERASSATVFRKRSSESSSAVDHRSKSLAPSQKIEKNRGRSQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q4L0</accession>
    <name>A0A3P7Q4L0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q4L0"/>
    <dbReference type="STRING" id="318479.A0A3P7Q4L0"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="73"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="144"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="246" mass="27441" checksum="8A0E9EBE55BA1DFB" modified="2019-02-13" version="1">MLRMSSRKSPERSKGQVKYLSQNEAIAIDQELFTEYGFSVDQLMELAGLSCANAVVRLANKCDDILVISGPGNNGGDGLVCARHLKLFGYKPTVLYPKQSKSDLMSRLITQITKMEIPFIKEESIQNPSDIEKNFSFIVDAIFGFSFIPPLRPPFDRLIDIVARCKTRVLSIDIPSGWHVEDGPSAFSVAIKPYALISLTAPKMCAKHFDGTHFLGGRFVPNSLIDRYSLNLPEYPDFESIMVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QEG0</accession>
    <name>A0A3P7QEG0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000523">
        <property type="protein sequence ID" value="VDN54291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QEG0"/>
    <dbReference type="STRING" id="318479.A0A3P7QEG0"/>
    <dbReference type="OrthoDB" id="5852427at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="113" mass="13358" checksum="07F526367260505C" modified="2019-02-13" version="1">MIRRLSTSNVTTDRFTPVLENFLKTANNVDTAKSSPNEFFLNLSKFLCFFMRYYNEMGKARKSRRNKELNIEIDFGQLVIVIQSGEIFSNEMNRLRTSFHCRKKTIKNFSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QFY1</accession>
    <name>A0A3P7QFY1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QFY1"/>
    <dbReference type="STRING" id="318479.A0A3P7QFY1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="115" mass="13223" checksum="43E080C4DB2380FB" modified="2019-02-13" version="1">MVEYTLIHFPIIINDKEKFSVEIDASQFHPSELFVNIRENELIVEGKHEERNNENGTIQHRFIRKYEIPSDVQMNTIESNLSGQGVLSINAKKVPSDNVPVRRISIKPSHPSNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SBH7</accession>
    <name>A0A3P7SBH7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SBH7"/>
    <dbReference type="STRING" id="318479.A0A3P7SBH7"/>
    <dbReference type="OrthoDB" id="6270617at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009635">
        <property type="entry name" value="NPDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352:SF2">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
        <property type="entry name" value="NPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="211" mass="23805" checksum="4B20530D3F65732F" modified="2019-02-13" version="1">MSYDDQSSYNSPNNQQQNPEETERIMEQFIELQGLGGKEDYYGKEFERPRKLKSRTGEPTALTAQKKGQNEFVELIEPKPANQLKHTEQIEKRVPVALAESKTIMQGNLALKSQSLASEKFDFARYAPAGPGREKKKRGDEGLAYKAQLHHYQQTKQKIISGDEQVAPVPDPDEMSEASDDDTNNFSVYECPGLAPTGDIEVQNPNFDTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SNJ9</accession>
    <name>A0A3P7SNJ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SNJ9"/>
    <dbReference type="STRING" id="318479.A0A3P7SNJ9"/>
    <dbReference type="OrthoDB" id="5877299at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="160" mass="16322" checksum="D2FDA19A9405BF71" modified="2019-02-13" version="1">MAAAIQGAALQQVAASRALLLRNPLAQAIAVRNLQGLSVQGQLAAIGAQQQLSFLNPAIAAQLQGQSLLLSAAQLPQATQQVPQAYDPAALLTEQARLQFVTSQGANPAFMAAAAARNAATAGTPAIGEQYLGSALTAAIPGYPAVAANTYRALTRFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SU86</accession>
    <name>A0A3P7SU86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SU86"/>
    <dbReference type="STRING" id="318479.A0A3P7SU86"/>
    <dbReference type="OrthoDB" id="5856491at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="103" mass="11710" checksum="7E317666B68E8852" modified="2019-02-13" version="1">MLQLISHHAYRNFKTIQYYLQLVLHMSFEVIVALGDLVLLTTDKSDLKCKIFIENKFILAYATPVQHGSSNISLQYILNAIVASNQANNQMSTPNNVQKRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TEK9</accession>
    <name>A0A3P7TEK9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">cAMP-dependent protein kinase catalytic subunit</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS10162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer composed of two regulatory subunits and two catalytic subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TEK9"/>
    <dbReference type="STRING" id="318479.A0A3P7TEK9"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN60189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="311" mass="35911" checksum="B3E841D5CADE717E" modified="2019-02-13" version="1">MDDFDRIKTLGTGSFGRVMLVKHKQNGCYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVKMDFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRFGNLKNGVADIKNHKWFGSTDWISIYQKKIEAPFLPKCRGAGDASNFDDYEEEPLRISGTEKCAKEFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0G4</accession>
    <name>A0A0N4U0G4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xylo_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4404</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0G4"/>
    <dbReference type="STRING" id="318479.A0A0N4U0G4"/>
    <dbReference type="WBParaSite" id="DME_0000004401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000004401-mRNA-1"/>
        <property type="gene ID" value="DME_0000004401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024448">
        <property type="entry name" value="XylT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12529">
        <property type="entry name" value="Xylo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Xylosyltransferase C-terminal" evidence="5">
        <location>
            <begin position="113"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000004401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43032" checksum="D7E4E0BB56EC6910" modified="2015-12-09" version="1">MTARNSRNSSELLLRIAANSIYCNRTMKGNLRLTNWKRKQGCRCSMLKKVVDWCGCSPLVFNKRTVYKFSIEVAKQRNLFFGRKFDSLISQYAISVAESQAYRMNLASLQVNHPSFNRTWLNIYSKEIDHSDLLISWSRSLIAGQESSISLKNCMFLTLISIYAYKEDDDADIETIMDVSLLCESRAIVVQFLIKKIAFSSFYDVMVDGFTLLSISVGSDVDLREEIFRNYAGVLSEDEIICTKLLWRQNVGSTNTSDLTSPSVKLEWSSPAGETKVSVVAPYDSVYGGQFGELFPNETYAGEWKVSVMAEISTGEKLLVASSQFLIYSHRHDVSSNVSLVTKYFTVKDICSMTHFSDIILCNETLWSHISPDPKSEFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0N4</accession>
    <name>A0A0N4U0N4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS4480</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0N4"/>
    <dbReference type="STRING" id="318479.A0A0N4U0N4"/>
    <dbReference type="WBParaSite" id="DME_0000012001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000012001-mRNA-1"/>
        <property type="gene ID" value="DME_0000012001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN54507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000012001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12563" checksum="F6604D0463E1EEA5" modified="2015-12-09" version="1">MDAGKVESGTVGAPGIGNQGPRPSNKRLQQTQAQVDEVVGIMKVNVEKVLERDQKLSQLDDRADALQEGASQFEKSAATLKRKYWWKNIKMIIIMCAIVVLLIIVIIMWLGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0U7</accession>
    <name>A0A0N4U0U7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4551</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0U7"/>
    <dbReference type="STRING" id="318479.A0A0N4U0U7"/>
    <dbReference type="WBParaSite" id="DME_0000019101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000019101-mRNA-1"/>
        <property type="gene ID" value="DME_0000019101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000019101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24487" checksum="9C2E25238F2142BA" modified="2015-12-09" version="1">MHRIFGSSTKKQVAPNLTDTAASIDSRIESIDVKISKLDAELVTLKNQMKKMREGPGKNQIKQKLLRILKQKRMYENQRDQLSQQSFNIEQTNMAIQGMKDTQTTVDAMKMGLKSMQKEYKKIDINKIDTLQDEMEEMLDMNNEIQEAMSRQYDTPDIDEADLEAELEALGDELELDAEGSYLDDALSAPGVPSKEPGAMEGGIAVDEFGLPKVPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U105</accession>
    <name>A0A0N4U105_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4616</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U105"/>
    <dbReference type="STRING" id="318479.A0A0N4U105"/>
    <dbReference type="WBParaSite" id="DME_0000025601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000025601-mRNA-1"/>
        <property type="gene ID" value="DME_0000025601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF112">
        <property type="entry name" value="LD11247P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="145"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000025601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58580" checksum="F04B22A999C21258" modified="2015-12-09" version="1">MMETKLFASENELDVFTHTNIPTIPITLNSVSIRIIFSNAIHLSEECYSTNSAIYFQLVEFRKFLILLHDDIISVEEITNNDFTESEKLPNIYLEIIAYPIISGKRQRLQIRFNFSDKSLAECWKTYISKKIDPPLPPHFQRKISRKRKILVLVNPFGGQKNAKKIWQNYIARIFQESHIDYDLIVTEREKHAIEIARCMDLDEYDAVAVISGDGLINEIISGLLLRPDRIRAMKFPIAHIPGGTSNALAASICFQCNEPFSPRKPFFLEAALMICRPRYLPLRICSVQTEKDGDRPMFLSVTWGLLADIDIGSERFRWAGLARLHIEAFLRIMRWHHIARKAFGKDHFRYDEISHFSSENDINVNNSHVNDEKIPLLNEQIPEHWTSVEGEYVFVCITNLSHLGSDVPYIPSSRLDDDYFFLSYVDWKLVKSRFQIMQMMLEMCNSGHLDYSCFQVIPVKACRVEPKDGCGGYLSIDGEPISPGTTFQVVPFGCVTIVGRNEVKSAHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1J5</accession>
    <name>A0A0N4U1J5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4841</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1J5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1J5"/>
    <dbReference type="WBParaSite" id="DME_0000048101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000048101-mRNA-1"/>
        <property type="gene ID" value="DME_0000048101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6432511at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF13">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="1">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000048101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38336" checksum="33D3ECCAAE7D8EEC" modified="2015-12-09" version="1">MLSCICISKVAIISDQSVMCYSDQMLVNLEFVEPFDGLIYIDESYNKEWCKWEGTSSLYLNLSIPTIDANKDAKSCKTSIKQSTGEISVSLIINPMRTVIVNGVTNLEVRCLYIVDDITVTLARITMKGISEQTGVVTGSGGTPAFLIQILDGHGIEGQAITEASVGQKITMDVLLKDTAIYDFVAHSCYAHDGTNSPDASVQIIDANGCGVKLARAIDVPVMVSQAKIGEPKHVYVHMYGFQFTSSQYVHFECQVRPCVHTCMRKQCDIANNNKFTSMRQLFRKLRDANSMQQLKLQTVLQMKPQIPFTSEFHFAFEGESATSNQASTRILLHRIIFHACNRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1W0</accession>
    <name>A0A0N4U1W0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4982</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1W0"/>
    <dbReference type="STRING" id="318479.A0A0N4U1W0"/>
    <dbReference type="WBParaSite" id="DME_0000062201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000062201-mRNA-1"/>
        <property type="gene ID" value="DME_0000062201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000062201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24356" checksum="E72FCB30130B060C" modified="2015-12-09" version="1">MGKRKIFNNEGDDDVNAEKVEMDEESSSSHIDAGCWSKQKLKHKRGNRVICPGIDTLSYKHAKRLMKRNENCGLVEIVDQQHITIGWHQCGNANEAVHQILTRIIGRYYPRLNGIPLAIGKISFPEENHKILADQPCLHIDVCLKIIIFRPVLGKTYDCVVTSISDTIVAANIFNAITFTAHLMNGKKKPNIGDIISIRYVSSNFKGSLCQMKGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Y2</accession>
    <name>A0A0N4U2Y2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5423</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Y2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2Y2"/>
    <dbReference type="WBParaSite" id="DME_0000106301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000106301-mRNA-1"/>
        <property type="gene ID" value="DME_0000106301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000106301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32540" checksum="50E8C4937A2C5B6E" modified="2015-12-09" version="1">YLNCCFILEQGGNASFDGYVIVCNQENIEEGTKLELPVDEDGLLPLATLSHSFPRAIGLKFKNPSTGVFRTLAKRSSHLSPIKPKRLVNEETKKILPPKNGWTKNCYVAIFNEDTKVYIILSICKPLPTEKMRDCIGLTYDCRRGNYVTVSLYDSILASERQKRLNDDDSDDPNSSDKRAILEASMTDVPVDLIVRNISFDTTQETLENYFRQYGEVIFAEVRVSNRIYLRICYNLQIKRDYKTGRPKGFGFIKMKNVADQTKVLEIRDHLIDGRVTQAVNRHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3L4</accession>
    <name>A0A0N4U3L4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NTF2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5682</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3L4"/>
    <dbReference type="STRING" id="318479.A0A0N4U3L4"/>
    <dbReference type="WBParaSite" id="DME_0000132201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000132201-mRNA-1"/>
        <property type="gene ID" value="DME_0000132201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950413at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000132201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10910" checksum="9A65A485FE40ABC3" modified="2015-12-09" version="1">MGVVAQDMLIRRFINGFFPKYMEFRINELIIKRRGNVVFVGGFLHYEHRLEPSKIYWMHGFAEEFLSILLKQPVKLELQFVPSPATLAYNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3M8</accession>
    <name>A0A0N4U3M8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PSI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5697</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3M8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3M8"/>
    <dbReference type="WBParaSite" id="DME_0000133701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000133701-mRNA-1"/>
        <property type="gene ID" value="DME_0000133701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSI" evidence="4">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000133701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18440" checksum="943EEFA5BA08D267" modified="2015-12-09" version="1">MLYKLSLSNCESFSSCFECISSYDPLCGWCLLEGKCIRRNSCQSDSIVNICPLYNLSTIPSNISVDDSQTKIFLPLGDFSQFEENEFICKYDEEISSGQWSDTGIICATPKNQLKIPSDSLIVDINVFYSTYNTVRIVYHQNGVVDGVQKIKDVFRIRILAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3R0</accession>
    <name>A0A0N4U3R0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3R0"/>
    <dbReference type="WBParaSite" id="DME_0000137001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000137001-mRNA-1"/>
        <property type="gene ID" value="DME_0000137001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877868at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000137001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36425" checksum="52AF6CC998D80F6F" modified="2015-12-09" version="1">MLFELVVDNLKLLKGNKQLSLCFLEQLQNEEESTNFPERSNQLYEYRTTNGNAIIRLCSDQCFNAYKLDILRQETTLSFFKNNPFQYVKETTQAQTKKLPIHFEKKRKKIKEARPHPSYRLNKRYWDDVRAGRLPHCYSNLRSKSNANMSIVDPSTLLNQFNYPSHYPIKASMIRQESIPSYPFSFSSQFSFCDAKKRNPSWMAKDANKIIEEAASNNAVKNNFNLAINTDIRKNMGGISESINCRIEDKYVDELADAMMLELNRTKYPHNLEHKQKSLGLVPFPFPFPIILPILLPITDQFLMERFNINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3W7</accession>
    <name>A0A0N4U3W7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine-rich cell wall structural protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5799</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3W7"/>
    <dbReference type="STRING" id="318479.A0A0N4U3W7"/>
    <dbReference type="WBParaSite" id="DME_0000143901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000143901-mRNA-1"/>
        <property type="gene ID" value="DME_0000143901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042226" evidence="2">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000143901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="29818" checksum="5BA5C4D7968CEB86" modified="2015-12-09" version="1">MPTPFERILLLVTLIGSSNACIGGGGCCCPQSQPSCGCGSTCGGGGGGGGGGGIIAIPPPPPSAYVAGPALHGGVYGAAPPAIGGAYSAPGAYGGGGGGAYGGGAYSGGAGGGTYSGGTGGGAYSGGAGGGTYSGGTGGGTYGAGAGGGAYGGGAGGGAYGGGAGGGAYGGGAGGGAYGGGAGGGAYGGGAGGSAYGGGGGGGPYGGGAGGGGGGGPYGGGAGGGGGGGPYGGGAGGGPYGEGGGGAPFGSAIPAAAPAPVVPSETYQEEALAPAPAPAPAPAPAPAPAPAPAPTYQETGGGFIESAPVPAPAPGETYQESSAPDGDGYQERLKFLKRTFQKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U407</accession>
    <name>A0A0N4U407_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5848</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U407"/>
    <dbReference type="WBParaSite" id="DME_0000148801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000148801-mRNA-1"/>
        <property type="gene ID" value="DME_0000148801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826894at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF30">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041162165" evidence="6">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000148801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12682" checksum="8E34EDD15DFA4208" modified="2015-12-09" version="1">MSLKIIAVFLSLLIVAFCRMQRITVKGQLACDNKAIQGVLVKLIEKDTLDPDDLMATTHSDRQGYFEVTGEEDEVGSIEPFLQIIHNCLDGVIKPVIYFVFFSFFLRRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U459</accession>
    <name>A0A0N4U459_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Troponin i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5913</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U459"/>
    <dbReference type="STRING" id="318479.A0A0N4U459"/>
    <dbReference type="WBParaSite" id="DME_0000155301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000155301-mRNA-1"/>
        <property type="gene ID" value="DME_0000155301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030172">
        <property type="term" value="F:troponin C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000005">
        <property type="entry name" value="Troponin I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF1">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000155301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32301" checksum="1998219955CDA2F2" modified="2015-12-09" version="1">MSDEDYCSEVPENEFEYRYGGPQAEEDEGTGDAEAKRKAEEREKKKAEVRKRLEEAGSKKKAKKGFLTPERKKKLRKLLMMKAAEDLKQQQLLKEQERQKVLSQRTIPLPDVDSLEDHGKLEEIYQKLFDHMIKLEEEKYDINQAVMAKDAEINELTIAVNDLRGKFVKPTLKKVSKYDNKFKKMAGQKKEDKQDFRANLKVVKKENVIDDIVNKKKTDKPNWSKKGEKPAETEEKKEAPEPEAPEEPEPQEEGQVEEAEGEGEEEEEGDEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U466</accession>
    <name>A0A0N4U466_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5922</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U466"/>
    <dbReference type="STRING" id="318479.A0A0N4U466"/>
    <dbReference type="WBParaSite" id="DME_0000156201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000156201-mRNA-1"/>
        <property type="gene ID" value="DME_0000156201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09341">
        <property type="entry name" value="LIM2_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000156201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33948" checksum="621305CEC3B0824B" modified="2015-12-09" version="1">CKGSLTEGNLVIYAERFEDDVHWHPQCFICTECSNILVDLIYFKHGADIFCGRHHAEKFKPRCAKCDELIFSEECTEAEGRTWHMSHFSCVECGTQLGGQKYIAKNERTLCVPCYHRNFSLACNTCRETINVEKPHITQISFDSNISTDCAHRRNSVPRPPLRNPPTPPNENIYETVLPFFSYNRRSHSADMRHSQTDKCKNCIKKADADLKRQNYYSRMPPSPSYRRRHRRCSSCSSSESDGEDIYLSKYLAVSLARYENMRDIKHEQKNQRNAVLNRMKASKNKSNNCIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U619</accession>
    <name>A0A0N4U619_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BBSome-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6696</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U619"/>
    <dbReference type="STRING" id="318479.A0A0N4U619"/>
    <dbReference type="WBParaSite" id="DME_0000233601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000233601-mRNA-1"/>
        <property type="gene ID" value="DME_0000233601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2154978at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028233">
        <property type="entry name" value="BBIP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596:SF1">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14777">
        <property type="entry name" value="BBIP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000233601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11023" checksum="A0052E1B05C20E0D" modified="2015-12-09" version="1">MSTELKEILGSYNGILFKEEALSPVFCKPKLIPLKSVTMNKLEEIQRESLIKMKEAIENASCDNETKEANILESNGQQSANQQIKADIWCAKSDKDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6I1</accession>
    <name>A0A0N4U6I1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tub domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6893</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6I1"/>
    <dbReference type="WBParaSite" id="DME_0000253301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000253301-mRNA-1"/>
        <property type="gene ID" value="DME_0000253301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000253301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34737" checksum="4C9E830D11C245B6" modified="2015-12-09" version="1">MEIFLKQFAARSGYSSKPGIINSRKQNYNRENRRAQCFSVSDAFLPEMDSINALLHFATTLPTKTKITSLSVCNPFYANGFLYFIDRMNPKQAFVFKTFPDPERGLIASFQTRIARSGIFTKCLVKQATIDCSSGMPFVGDEVVWSNVQTFNNNAFFLIQDLKINTCVLWRIQLDSTITEENSKDYEVNEIHIDKGEPNDKRRHCTIIHISDSDTVSYSKYPHKNKNTSKSEFSNSLKWQKIQEFNVSMFKLFDNSALHFDTKENYAFVKGIKTDYNGKSIGHCFIAFLVQYKFENEIPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8M3</accession>
    <name>A0A0N4U8M3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF4515 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS270</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8M3"/>
    <dbReference type="STRING" id="318479.A0A0N4U8M3"/>
    <dbReference type="WBParaSite" id="DME_0000340401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000340401-mRNA-1"/>
        <property type="gene ID" value="DME_0000340401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019177">
        <property type="entry name" value="Golgin_subfamily_A_member_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815:SF7">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
        <property type="entry name" value="GOLGIN-84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09787">
        <property type="entry name" value="Golgin_A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="82"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000340401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30755" checksum="FE550489FE970203" modified="2015-12-09" version="1">MFKEAEEALIQKDIKAAELMRDMEQKIELKSRNPDNELSTLIGLEQSYKAEIDQYNKREKELCKRLQISSEEKTILLMKHNLEVQKNEFDEYKQKAQKVLNAKEKLLESLKEVEIFFLFQEYDFLHNELQRQEKAVEKKLIEKDAELLKLMEEKKQRKRYEKGEIEEKIAMMGEKIIAKQTEIERLESEKRALEFRLERSELIPYCFSLRLVTSMRNPVFRIFILIYSTILHAWVFFIIMTYTPEMHSPKKPFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Z6</accession>
    <name>A0A0N4U8Z6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS7541</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Z6"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Z6"/>
    <dbReference type="WBParaSite" id="DME_0000353601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000353601-mRNA-1"/>
        <property type="gene ID" value="DME_0000353601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000353601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="28596" checksum="8415124CAF431C9A" modified="2015-12-09" version="1">MLWTKNAAIASIFFSTLVIAVIAYQIYALLNSVILAKQKLAAHIDEFNLMQNEIWADLLQIRAKEGPKSRITRQIAPGCNCKTTGRCPPGPSGRPGADGRDGTPGTPGLAGPPGLPGIALPVEARDLESCRVCPPGPPGYPGYPGVPGPPGHEGMPGPDGLVGHLGQIGPIGNPGDNGEPGPVGQDGLAGPPGRDGVRGLPGPPGEPGPRGPIGPKGFKGPPGNPGNNGQPGPNGPPGEAGQEGQKGYPGTPGTLGFAGNPGEDAGYCPCPKRQRRTHANKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U985</accession>
    <name>A0A0N4U985_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AFP-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7639</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U985"/>
    <dbReference type="STRING" id="318479.A0A0N4U985"/>
    <dbReference type="WBParaSite" id="DME_0000363401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000363401-mRNA-1"/>
        <property type="gene ID" value="DME_0000363401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9992747at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000363401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28535" checksum="47EA2034B65A7DEF" modified="2015-12-09" version="1">MPVSHLLGYGASELKEIADNKAKIHPQNLAFIGVRSYEPPEIELLEKIGVRIFFMEQVQKRGIHDVLKEAIEIVSKKTIGFGLSIDIDGFSPCDAPAVGTPVSGGINAKNFMDAIKKQDLSLLLATEIVEFLPGFDDEYQKRLINKMCSQPKVLARNLSRGTQEAFCTRSEVLAVSAWNVRTLVDVARQAITVHTLSNYRVDIVRLSKVCVPYFGSRAIINPGLEQRYWLYHCDASNNSGRNGVAIHVSQDPFRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9H3</accession>
    <name>A0A0N4U9H3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Venom peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7747</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9H3"/>
    <dbReference type="WBParaSite" id="DME_0000374201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000374201-mRNA-1"/>
        <property type="gene ID" value="DME_0000374201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835927at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039891" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000374201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9121" checksum="B907177691BB34F9" modified="2016-06-08" version="2">MNTFTTWLLIFVIMVGETSEKPNSFFISKNGPELENFPLEDISDFDLHPYIVAYKRAMMRLGKRSVFRFGKRALMRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9R9</accession>
    <name>A0A0N4U9R9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAB6-interacting golgin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7854</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9R9"/>
    <dbReference type="WBParaSite" id="DME_0000384901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000384901-mRNA-1"/>
        <property type="gene ID" value="DME_0000384901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849607at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000384901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13723" checksum="0A502E35AB1C3BE8" modified="2015-12-09" version="1">MDHFVQQSRRGIGQTRPVGWKSIPPPCEAVRAKILENIRLRQQKEEKDRAMRVARAKEREKKVDMCTSHQEEIAKIDIKIKSIDERIFELGVLKSKIFSELKEVVAKEKIERKKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAN8</accession>
    <name>A0A0N4UAN8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8112</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAN8"/>
    <dbReference type="WBParaSite" id="DME_0000422901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000422901-mRNA-1"/>
        <property type="gene ID" value="DME_0000422901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5779735at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000422901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30712" checksum="BB47E94A738C2591" modified="2015-12-09" version="1">MTDEKKAILIQEIALRPLIWKISHPNYDDVEKRWLAFEEIARLLSDEQVIFTSDMVKLTWKNLMDYYNELQKRYNRIVAAGMDPPEFKWQFFHMLHFARQDKAFVKRKYNYMQPSKVTLENASASFNQSCDYSPNFQQSSLINVKTANGSKHIVILPMKQSECTIPQFERFSGITAHHDVSNGFTGKSTKQTNDEQIVGNSFPAHYAKIDQKPVAALDSISSFARYIAARLYLVKDKCPSKYLSLCYAIDGTIKKAMREINIVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAU9</accession>
    <name>A0A0N4UAU9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8185</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAU9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAU9"/>
    <dbReference type="WBParaSite" id="DME_0000430201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000430201-mRNA-1"/>
        <property type="gene ID" value="DME_0000430201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000032">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF27">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 71E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="34"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000430201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29670" checksum="0C20996D9F1A958C" modified="2015-12-09" version="1">MTVTTLGYSMVICGNSHDPQQRYRGRIEKVKFGVPIQEAFSRDIPATLLILLLKVNKDGPSKKDIWRAPGNQAQVRKLAHTMQHGRLVNIANFSVYTAASVIKKFLSKLPGGIFGLENERLLFDLFYQSDLENQRQVFCRVVSSLSIPSQHLLVLLFGTFFLISDSADVFNTRMTPDAIGISVAPSLFHTCIHDGQRAKMEDVMRFKMASEVISKIIQSFGHVNLFPRECYEFYARITGRALRIDENEARFKFAPATGKFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB90</accession>
    <name>A0A0N4UB90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHTB1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8338</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB90"/>
    <dbReference type="STRING" id="318479.A0A0N4UB90"/>
    <dbReference type="WBParaSite" id="DME_0000445501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000445501-mRNA-1"/>
        <property type="gene ID" value="DME_0000445501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 platform" evidence="3">
        <location>
            <begin position="117"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="4">
        <location>
            <begin position="218"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000445501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46506" checksum="F157626A144FDABF" modified="2015-12-09" version="1">MKSGDPICTSNALEKEAKQTRIVEYPTGLAQEIAEDIPSLTVNVEIRSERMVKDVRLLCSTQFFVDEKYHSLESLNGTKIIPLIFYTKQEAVTDLRCTFFLTSSSCGEVCNREIKLPLSLMCRTVSTQRNALFKLTLESTMDNILSISDLFPEFEAESQTSIGFKPFLSDSVISIFISPKTKRYRIQSDSLDWLYLYADEIVSRLTSQQPNMNFSCALPIDQILQKLHNFIELQKRSNSEEKELERLAAQIRGAQSAILIKIKNQRPTSISHLEAFYRITHSQMLNMIDKSMETESELNLAAKSLSASLNLLNFLANVNGNAMAIDGKVTHGPYQEIAERIKWILAMITRSEIVSDISPAELKSMIRIQCERSAARMENIDEEIEDNESENEDIGINPCVSGSLPYTKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBC2</accession>
    <name>A0A0N4UBC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SAND domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8377</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBC2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBC2"/>
    <dbReference type="WBParaSite" id="DME_0000449401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000449401-mRNA-1"/>
        <property type="gene ID" value="DME_0000449401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059099">
        <property type="entry name" value="GMEB1/2/Spe-44_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF4">
        <property type="entry name" value="SAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25892">
        <property type="entry name" value="Spe-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAND" evidence="8">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000449401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39641" checksum="D806E6855F261B5E" modified="2015-12-09" version="1">MSVVDSDERVLPSRTPSEDLNSTVLEVKCGQLIARLHTDKFICPGIHQPCIELDGEMISPKEFTIRANKDKQKDWKGSIRIGKSNMRSLMECKSLDFYNHDTYCSAKCQSRNYITSKNFVGDLSLKPDVFFGASTSNCELSDTNPCGNTVISNALQRLVNNPSALASISIMSDQLILSTLLSSGNSGRTTDGAVLKQEDSVDRSHLTNISRAMQDQPVKFWTMVSDMGLFDEFMNMIITAINQTQRLVSMGSAQRDAVAEKLSQMAKVFELEDIISTRIHAKRLQYLVDTNLLKNKFQAELQRKTEECRRELEEARRRVAQIDEIVLDPLLFPVKRSRLSSTEDVIGGMAKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBH9</accession>
    <name>A0A0N4UBH9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8440</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBH9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBH9"/>
    <dbReference type="WBParaSite" id="DME_0000455701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000455701-mRNA-1"/>
        <property type="gene ID" value="DME_0000455701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876278at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000455701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="23552" checksum="7A15A5F6E3C6DB25" modified="2015-12-09" version="1">MREFNEIETDIYTYAQEKFTTNSPSFRIHRSKRQITSPGRCNCISQNTCPPGPPGPPGIPGSDGTPGRPGLPGAPGIPGNYPPVAINLDANCRICPGGSPGFPGSPGLPGQAGELGPPGPPGPRGEPGFPGPQGQPGPAGEMGSAGKNGPPGPPGRGGFQGGKGEPGTPGQKGPLGPPGIPGQNGNDGNQGFSGPQGPPGPPGEPGAPGPDGVPGPIGPSGGPGEDASYCPCPPRKNVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC46</accession>
    <name>A0A0N4UC46_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Degenerin mec-4/10 cytosolic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS8704</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC46"/>
    <dbReference type="STRING" id="318479.A0A0N4UC46"/>
    <dbReference type="WBParaSite" id="DME_0000482101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000482101-mRNA-1"/>
        <property type="gene ID" value="DME_0000482101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000004">
        <property type="entry name" value="Degenerin unc-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054001">
        <property type="entry name" value="Mec-4/10_cyt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF275">
        <property type="entry name" value="DEGENERIN MEC-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22214">
        <property type="entry name" value="Mec-4_10_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Degenerin mec-4/10 cytosolic" evidence="15">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN58731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000482101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="734" mass="83270" checksum="8807274FD7A62C87" modified="2016-06-08" version="2">MAWVQNRKNFERLIDSAEYMNAVYGSPLAYLKENEQVKFVTEREYYGDLGYGECFNSTSSGTQCEIITGEFNPDLLPYDKKMAWHLKEFCYKTSAHGIPMIGRAPNKIYRGVWILLFLGCLVMLYLNAISVLDKYHRNEKIVDIQLKFVELLRSQKIFADSAPFPAITLCNLNPYKVSQAKNVDMVQRTLSAFNGAMNKASGDSAISNQQRKKRFTKLNLKTSLFEPGYSKCECPQNQNGAECEGEKYKSEEPKNADEKCLCAFDRNTNDAWPCYLADQWVQEICENCDSRAFCSRSKSLYFFFKGNLSLIIFLNKSRNNSFLASKERENVSPCLCAPSGKFCVAYDGKSSILEIWQYLAGGAPTEDPAFLEAMGFEGMTDEVAIVTKAKENIIFAMAALSMEERKQLSTTKRELVQKCSFNGVACDIENDFLTHVDPNFGSCFTFNHNRSHHLTSIRAGPMYGLRMLVYVNASDYMPTTEATGIRLTIHDKEDYPFPDTFGYSAPTGYISSFGLRLRRMTRLPAPYGDCVPDGKTSEYIYKNYEYSVEGCYRSCFQQLVLKDCKCGDPRFPVPDGHVHCEAANPVARKCLDERINELGGLHGSFRCRCQQPCKQAMYSVTYSPAKWPSQSLQIQLGSCNGTPTECNQHYKENGAMIEVFYEQLNYEMLTESEAYGLVNLLADFGGQLGLWCGISFLTCCEFAFLICETAYMAAQYNYTLWKKKKAEKEKARQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC49</accession>
    <name>A0A0N4UC49_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8707</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC49"/>
    <dbReference type="STRING" id="318479.A0A0N4UC49"/>
    <dbReference type="WBParaSite" id="DME_0000482401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000482401-mRNA-1"/>
        <property type="gene ID" value="DME_0000482401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000039">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041474436" evidence="11">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="32"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000482401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="44218" checksum="654D8C917D4B9396" modified="2015-12-09" version="1">MFFYKLLLILITTTMLNGDKFCSNDSDVTNYLLKETKLNYNRHILPNRPVVVRIELWIQEVTSVSELTQDFEIDLYVNEFWEDPALSYELLRPCKMNLSFDHNMQESIWIPNTSFINSKKALIHSSPFKNVFFMIFPNGSIWSCWRIKSTGPCRMDLTKFPMDYISCILTFESYNYNNKEVNMKWNQPYAVLLFKDIELPDFTLVNYSNKIIEAEYAAGSWDELTVSFTFKRRYGWYILQGYIPTYLTIFISWIPFYLGPKAMPARTMIGVNALLAMTFQFGNIIRNLPRVSYIKAIDVWVLSGMTFIFASLIELAMVGFMSRNEGQIIISQFLKRKRKSICFDSEKLDLFSRTAFPIAYAIFNVAYWGYYMGGKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCT6</accession>
    <name>A0A0N4UCT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8898</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCT6"/>
    <dbReference type="WBParaSite" id="DME_0000509901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000509901-mRNA-1"/>
        <property type="gene ID" value="DME_0000509901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792800at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000509901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25782" checksum="B5C8DC2C4FDBBBB4" modified="2015-12-09" version="1">MIGQSFTNIISPMLSNLSAQTEIINQGQSEMPKRNAFNNENRNSYGNAFFDFANAILRAPSERGEYSLRHRIQQNQYDHNIDPFLTIRQLAPGARNNFGIPQGEGCLPFLTEVMKLAYGNCVKEADEKAWDTWSDQINNALFGGKVDLLYATKETCKRGAERQHCGQLRKVISECDILGSLQVAIQMQRAIKRCDDISGIVDQNPIQVLNQMNGIIGGEFAHGFIHKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCW8</accession>
    <name>A0A0N4UCW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8932</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UCW8"/>
    <dbReference type="WBParaSite" id="DME_0000513301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000513301-mRNA-1"/>
        <property type="gene ID" value="DME_0000513301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056771">
        <property type="entry name" value="FH3_FHOD1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24959">
        <property type="entry name" value="FH3_FHOD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHOD1/3-like FH3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000513301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="4969" checksum="A0F0FC2CC79E8E37" modified="2015-12-09" version="1">MGQVMLYVDGMNGIIAHIETVQWLYELLDSPVGLNFCSFYRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDA1</accession>
    <name>A0A0N4UDA1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9092</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDA1"/>
    <dbReference type="WBParaSite" id="DME_0000529301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000529301-mRNA-1"/>
        <property type="gene ID" value="DME_0000529301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000529301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14058" checksum="0229044561E30355" modified="2015-12-09" version="1">MSDQRTWQGDNNAINFNIAILLTVTFISVGLLVTSELAFFLHCAHLLVWLVPQGIIIVAIKLDPSALTAEDDDVDCDNDDVDRNGSDIVSQICPMKHAKVWPPGISAPSGRIMPHFDTLSNLQLYSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDR4</accession>
    <name>A0A0N4UDR4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS591</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDR4"/>
    <dbReference type="STRING" id="318479.A0A0N4UDR4"/>
    <dbReference type="WBParaSite" id="DME_0000548501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000548501-mRNA-1"/>
        <property type="gene ID" value="DME_0000548501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431817at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000548501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6309" checksum="221B633D82015336" modified="2015-12-09" version="1">MLANYFFDQGSISKLQTFFINVHHLAIVCDPPFGVFMDALMQTIKNLKEKFLATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDS2</accession>
    <name>A0A0N4UDS2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FANCI_S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS601</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDS2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDS2"/>
    <dbReference type="WBParaSite" id="DME_0000549501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000549501-mRNA-1"/>
        <property type="gene ID" value="DME_0000549501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836131at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000549501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31116" checksum="54638732A4C7ED8E" modified="2015-12-09" version="1">MVKRQQWTLRFQGLTKFGKVVAISCLTQVLSEDAFESQNLVISFVHTGALQHLLDSITAISFVDDRNSRRIYEYVSLLKTIITLLIQLSLTECGWNFLNDLCVLEKLASLQLWQNPPKALFLDPKEVSKSTKVNDDIDARKSDISQTYMECINNLVHFCLSSCSNPYWKRISHQVIAMITVHCEVFNHLMRNKLQGTLLSSCCKLLSHIYFLALILKKNLFIRLFHFSCQKSIVDVISDTSTRPIIEQSVCLNELRKLEKKGDEKVGKHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE69</accession>
    <name>A0A0N4UE69_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5 11">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS703</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 11">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5 11"/>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE69"/>
    <dbReference type="STRING" id="318479.A0A0N4UE69"/>
    <dbReference type="WBParaSite" id="DME_0000565801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000565801-mRNA-1"/>
        <property type="gene ID" value="DME_0000565801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="12">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000565801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="484" mass="53195" checksum="57DFDA460919D74E" modified="2015-12-09" version="1">MNAAYVNPMKIFDVKRSKYNGTNLLKDCLSVNDPQAYQIIRNEKARQRGNLELIASENFTTRAVYEALGSSMSNKYSEGYPGARYYGGNEFIDEMERLCQQRALQVFGLDPELWGVNVQSLSGCPANFAVYTALVEPNGRIMGLDLPDGGHLSHGFFTPQKKVSATSIFFQSMPYKVDPITGLIDYDVLEINSLLFRPKIIIAGTSCYSRLLDYARFRHIADKCGAYLMADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAIIFYRKGIRTITAKGEKIVYDLGPKIDSAVFPGLQGGPHNHTIAGIAVALNQCLTEDFVKYSKQVLKNAKALVDRLISLGYSIVTGGTDNHLCLVDLRPIGLDGAKVEFVLDLAHITCNKNTCPGDLSAFKPGGIRLGTPALTSRGFNESDFFKVADFIDEGIKILKKYESKLGKTIKELKSFAASDSEFKSDVQDLAKRVENFAISFDIPGKEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UED2</accession>
    <name>A0A0N4UED2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9326</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UED2"/>
    <dbReference type="WBParaSite" id="DME_0000573301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000573301-mRNA-1"/>
        <property type="gene ID" value="DME_0000573301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867312at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000573301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18945" checksum="9247ABAF21B00E06" modified="2015-12-09" version="1">MQVGQVVGGTLPMLWNASIYKIIRAIWNANIEDLLPQVDQVAIMEYYNEKTIEENEDENFFSKLWNLIKRLFGVTKEEYQCYANEPRCIRLAVNDLSKRERILLDEFFKNDNLTEIVKFIENKLSHNPETLREFYQWQAKNVVPEALKEIITSLTQAQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF99</accession>
    <name>A0A0N4UF99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1037</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF99"/>
    <dbReference type="WBParaSite" id="DME_0000609801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000609801-mRNA-1"/>
        <property type="gene ID" value="DME_0000609801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000609801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7955" checksum="F7BEA4BFD9BEDD13" modified="2015-12-09" version="1">MIERIGGTDLPEMDTSLASTSMITNEMNYNEILDRFTRNEIAYDDFMQLTGSFFFYTIQSHIFPNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFX0</accession>
    <name>A0A0N4UFX0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9471</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFX0"/>
    <dbReference type="STRING" id="318479.A0A0N4UFX0"/>
    <dbReference type="WBParaSite" id="DME_0000636001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000636001-mRNA-1"/>
        <property type="gene ID" value="DME_0000636001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409763at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000084">
        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000636001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40229" checksum="A258F9C66817A671" modified="2015-12-09" version="1">MFFNFRNFSSQTGFEEAQKKLKTLSEDPGADIKLKIYALFKQATLGDVSGQRPGALDFVSRAKFDAWKKLEGTSQESAQQCYIDLVDSLIGSQEPLNTTVAGLKPVSGLNISIEGKIFKIRLNRPSKFNAITLEMYNGITEALNYSSTDKTTSVTVLTGTGNYFCSGNDLSNFLEVKRVEDIPIMAAEAARVLDAYTTAYILHKKPLIGLINGPAIGISVTLLPLFNLVLASDKATFHTPFTALGQSPEGCSSYTYPFIMGMLKASEVLLFGRKLTAIEAMERNLINEVIPDRTFFDESQKRVEIYSKLPPESLRMNKQLLCDAHSEALMECKAREIKLLEQRWQSEECIAALKQFINRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG30</accession>
    <name>A0A0N4UG30_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS9536</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG30"/>
    <dbReference type="STRING" id="318479.A0A0N4UG30"/>
    <dbReference type="WBParaSite" id="DME_0000642501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000642501-mRNA-1"/>
        <property type="gene ID" value="DME_0000642501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF43">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000642501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="683" mass="77080" checksum="323BAB83320BFA22" modified="2015-12-09" version="1">MAQLIAQFEAPNLRNIFFHPQTKISYWIDLCADILKAIGVVLFNNERVYRCGYLVDTESPVEQISPDITTLYEVFMHGLEVSGDGPCLWRRLSAKQPYHSMKYSEVLEQSRKFGSTLIGKLNHKAGNETRIGIYSKNCVEWFLTAMACIQYSMVIVPLYDTLGPEAVKFIIEHCELSSIVVSDSEKAKKLLSANIECVKNIILIDTTNIGEVINLVTGQVKIYAFQDLVSQGDEYSSEIVLPKPDDIYIICFTSGTTNIPKGVIITHRNLNANISSYHFMLKTFFPDFLTPGQIQISYMPLAHMGEQDSHWCMFISGGSVGYYSGNMLELLNDAQDLRPTLFPAVPRILNKICGEIQENVKKQNFLVRSLYHFAYQRKLSLFKKGIITTDSIWDRIIFSKFQKLLGGRVQLVGIGAAPASAKILETVRVIFGVVLIEAYGQTECSGMITTTWPDEKEGNHCGSPFGCTLLKLADVPELDYYADKGKGEIMVKGPHVTQGYFKDPEKTAELFDDQGFLHTGDIGEILPNGTIKLIDRKKNIFKLAQGEYVAPDKIENVYSFAPCVQQIFVDGDSLERFLVAIVVPVESVMKNWFKENFGDSEKPYKEILTMKEAKDYVLNELQKIGKENNLNSIEQVKAVHLTCEAFSMENGLLTPTMKIKRAQLRKLYRQIITGLYKTTPYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG92</accession>
    <name>A0A0N4UG92_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9608</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG92"/>
    <dbReference type="STRING" id="318479.A0A0N4UG92"/>
    <dbReference type="WBParaSite" id="DME_0000649701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000649701-mRNA-1"/>
        <property type="gene ID" value="DME_0000649701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000169">
        <property type="entry name" value="Serine/threonine-protein kinase 32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000649701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31674" checksum="E95843756B9BA4DA" modified="2015-12-09" version="1">MYMVSDLLLGGDLRYHLHQQGRFAEDRAKLYICEIALALNYLHGEMIMHRDVKPENILLDDQGHAHLTDFNLATRLSPKTLATSFSGTRPYMAPEVIMSSLGIAAGYDHRVDWFSLGVCFYEMLMGRRPYEYNASLTSQQVLVLMKQSIIALPSHWPSDLISFITSMLRFSINDRIASLLSFSRHKYMERINMDAVLARKTAPVFIPRSDSLNCDPTYELEMRIVGSSTLSRPKDLTPTSKEEIDRAVEEITRAFTAYNRQVHNLSQKQVISVKICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGA6</accession>
    <name>A0A0N4UGA6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9626</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGA6"/>
    <dbReference type="STRING" id="318479.A0A0N4UGA6"/>
    <dbReference type="WBParaSite" id="DME_0000651501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000651501-mRNA-1"/>
        <property type="gene ID" value="DME_0000651501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="FPL" evidence="5">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="6">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="6">
        <location>
            <begin position="329"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000651501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="662" mass="76794" checksum="E33065A1B2C254B4" modified="2015-12-09" version="1">MLLVEALRALAELLIWGDQNDSAVFDFFLERQMLSHFLSIMRQKCGSYICVQLLQTLNILFENMRHETSLYFLLSNNHINSIITHKFNFDNEEIMAYYISFLKTLSFRLNTNTIHFFFNEASREFPLYVETIKFFNHSESMVRIAVRTITLNIYKVRDESMQNFVRLKSRQYFCILIDSIAQNSVEIDQFARSAENESSNRDRLSGLVDEYIDYVHYLNDIFLAKVALLSEIIFQHLLAPLYLCSLCTVRLCCKAVLITPVSALFFLSNFLLIITESQVFDYYKNILFIFLIWTDVHFMVFFDHSSFFGILLLYNIRFLKKFNLCDMGLLRIEVFTVSDSAVRTITVELCCIVLRQLLLEIVNTLSSVVYSEDLFLEMFEDEYYHFEVHFQFILFFVDPSLLLPPSNTPLSGVQLKKRLPSGNEERIRRSIQLFFHIRKFIFDLMGKSDIYLPLSSADNAAVELNDCINLDNSDLLSCTVVISKSERLQRFLVADQIQLILVEPDSKRLGWAIVRFVGLLQDTHITGDPSDSRALHIVVNDARSRSEKRTDPLLTAKFIFDDHIRCMAAKQRLTKGRQKARQSKLDLICDLLEMPKKNSFVVHNKNPFRIVRGCVPGSIRKQLSRSPSSAKSSSTSLNIVPDDPKPEQSPSFYRKLHGIQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGJ0</accession>
    <name>A0A0N4UGJ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pheromone-regulated membrane protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1256</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGJ0"/>
    <dbReference type="WBParaSite" id="DME_0000661201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000661201-mRNA-1"/>
        <property type="gene ID" value="DME_0000661201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867298at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000661201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28237" checksum="6BC5E65F5FD2AE19" modified="2015-12-09" version="1">MSSSECVYNDTDGGFRDDLALLPDSNSSSNYITCLSKSLIDDATSRNIFINDDVKASPEAQSSKVVFALPDHEEVKIKHSVPTDRKLLKYSSETSFIETNSESSNELERITNNRKLRHLSVHHTSTFIRANGGNSLFNRIRRHRQHESDSGSIGSETTVASGIMTPVERQRDRFRIGRPKSAGQMSYSDANSSNAITLQSLDSFHPFTVKLSERDETSDNAYNMDDDSAHEFDEKDGKPLYIFLSFPQINSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGZ9</accession>
    <name>A0A0N4UGZ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGZ9"/>
    <dbReference type="WBParaSite" id="DME_0000679101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000679101-mRNA-1"/>
        <property type="gene ID" value="DME_0000679101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000679101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8423" checksum="8937C35DB15D7F81" modified="2015-12-09" version="1">MCLNVHLALNQHLRMPTTCYPLMIFQPSKLCRFYHARVASCGQSRQYTDRRWIQYMKIWLYLIRGLENSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHD4</accession>
    <name>A0A0N4UHD4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Adenylate kinase isoenzyme 1</fullName>
            <shortName evidence="29">AK 1</shortName>
            <ecNumber evidence="29">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">ATP-AMP transphosphorylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">DME_LOCUS1536</name>
    </gene>
    <organism evidence="32 34">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31 33" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP.</text>
    </comment>
    <comment type="function">
        <text evidence="29">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>CDP + GTP = CTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79859"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GDP + ATP = GTP + ADP</text>
            <dbReference type="Rhea" id="RHEA:27686"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + UDP = UTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79863"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>UDP + ATP = UTP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25098"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:24036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dADP + GTP = dATP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79871"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>dAMP + ATP = dADP + ADP</text>
            <dbReference type="Rhea" id="RHEA:23100"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dAMP + dATP = 2 dADP</text>
            <dbReference type="Rhea" id="RHEA:78311"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dATP + AMP = dADP + ADP</text>
            <dbReference type="Rhea" id="RHEA:79899"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dCDP + GTP = dCTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79875"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dGDP + ATP = dGTP + ADP</text>
            <dbReference type="Rhea" id="RHEA:27690"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58595"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dTDP + GTP = dTTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79867"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>thiamine diphosphate + ADP = thiamine triphosphate + AMP</text>
            <dbReference type="Rhea" id="RHEA:69180"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:58938"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 29">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 29">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="29">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the adenylate kinase family. AK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="29"/>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHD4"/>
    <dbReference type="STRING" id="318479.A0A0N4UHD4"/>
    <dbReference type="WBParaSite" id="DME_0000695701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000695701-mRNA-1"/>
        <property type="gene ID" value="DME_0000695701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009142">
        <property type="term" value="P:nucleoside triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03171">
        <property type="entry name" value="Adenylate_kinase_AK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028582">
        <property type="entry name" value="AK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006267">
        <property type="entry name" value="AK1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01360">
        <property type="entry name" value="aden_kin_iso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 29" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 29 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 29 30" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="29">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="29">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048620"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00059689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="VDN51563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="WBParaSite" id="DME_0000695701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23642" checksum="88CD4E5E9C3A8888" modified="2015-12-09" version="1">MNYDEYAPIERKKIDLSELKKANLPIFFIVGGPGSGKGTQCDKIVAKYHLTHLSSGDLLRAEVKSGSPRGAQLNKMMENGELVPLEVVLDLIKEAMLAAVKKGTKGFLIDGYPREIKQGDQFESEIQEAKLVLFFDVCEDTLVKRCLHRAETSGRVDDNIETIKKRLHTYITSTAPVVEHYAKKGKLAKIPSEGSVDEIFKAVEVHLDKIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHG8</accession>
    <name>A0A0N4UHG8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD and tetratricopeptide repeats protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9797</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHG8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHG8"/>
    <dbReference type="WBParaSite" id="DME_0000699801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000699801-mRNA-1"/>
        <property type="gene ID" value="DME_0000699801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000699801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67802" checksum="4887A34134556187" modified="2015-12-09" version="1">MPIFLDDRCSIERRFLRRELHSSPINFVRESVAERHLIEHLTHSLTLEGHEGCVNCLQWNRSGTLLASGSDDMQVFLWNIKGEKVHSFNSGHLNNIFSVQFLPGGADEIILTASGDSSARMHVLSGRNSDPPTVWWSDGRVKRLAVTNSDPLIFWSASEDGLIKQYDARTSTALSLIVFPGKECKSLAINETRPEMIAVALNEAAVPIYDRRNLSKPLLELIPGHIPITKLNSRHSFRSLSVTHVGFNSLGNEMIANIGGEQIYIFNVLDRVNEPDTLQSLNEVFERNVPYSENIDNIEQKGSERFKATRERAKIHFNNREYTNAIEMYSYAVLECEKLCGTDPPPDREYAIDLSILLSNRGACYLRRLWEGDAYASLMDMIRALKIEPRNTKLYYRIVKALVELKQYDSARKIIQSFKQRFPGYVMADRLDGMVDDNSTTEVEWKSSTTSDYMQRLCGHCNTNTDIKEAVWFGGNDEFIAAGSDCGSLFIWERNSGALIKGFKADNNILNCVQPHPSCCLLATSGIERVIRFWEPLNKNVSEADSCREHRNLSTLCAENQRRMNTGFFEMVVASIGFAVQNDFDDERQDRNFGCNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHP8</accession>
    <name>A0A0N4UHP8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1615</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase II family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHP8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHP8"/>
    <dbReference type="WBParaSite" id="DME_0000708901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000708901-mRNA-1"/>
        <property type="gene ID" value="DME_0000708901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261598at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09120">
        <property type="entry name" value="PLDc_DNaseII_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09121">
        <property type="entry name" value="PLDc_DNaseII_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858:SF24">
        <property type="entry name" value="CELL DEATH-RELATED NUCLEASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041676" evidence="3">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000708901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45321" checksum="6BA73D64FBF60F93" modified="2015-12-09" version="1">MFLAVFISAIVVNYALNEIEDFQCRDQSGDPVDWFIFYKLPKIETVLNSNIKEGIAFLYMDSKSKNWKLSDKSIADKNQALSYTLEQNYRLLHETQVRLLRPKSLTEFSSKKLAWELGRTSVKDKLFQVLSIYYNDEFPFPQEHVCSDVSGHTKGLIAFYEENGYWLIHSIPKFPRNDTYEYAFNARIYGQMGICVSLKSTAVQDIAIQLYYSWPNIYSINIPKIFGKDVPILYKLRNGEHAKGQPTNRTVSLTSTSGQNFMHFAKTAEFRRDLYADFVAPTLMSALAVETWQHGAKDGNLGPFCKSNHHRVLDIKSVKRPDGGVFSNYLDHSKYAITIDNGFNTVCVGDINRQVQQKVHQLKRAGGTLCLQDANVHRSYQNLIAELSKCPNNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHS6</accession>
    <name>A0A0N4UHS6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9851</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001193">
        <property type="protein sequence ID" value="VDN59878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHS6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHS6"/>
    <dbReference type="WBParaSite" id="DME_0000712101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000712101-mRNA-1"/>
        <property type="gene ID" value="DME_0000712101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279276at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF55">
        <property type="entry name" value="FI23523P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000712101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44623" checksum="87DB288A13C73A06" modified="2016-06-08" version="2">MGNCVSQAGQKEFLRSLPSTAIVNSISNGENSESFRVFVKKRNKFIPGTLIVNENGIVFCRNQTESLNWPLHCLRRYGFTSAGIFFFESGRRCPSGEGLHTFQSHQAEAIFQLVQSKIRMNVNFEASKCHIRSQSMADSVHSVHSLMGGNTPLGSRIHPVQRYSSEGTASVGELPFNYGYYGNNRLLNGVRRPRSIATAAGHTAIWPISHGYRPNQYHTVQGEFMGSVINEHIIQRQPSILNHSYVNVTTHPRKQVFDQMVSSQFRIAKNNHLILESMAKSRLVPVYRSISETNSPACEKFFHDRYVNVNDMNSNCEKEMTPAQLDYAAVDIGVTDVYNCLSQRTGSISSPSCHDDPSVTCSLNVNYAQIDLEKTHAVEAAATVLQKENRLHYITGNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIY5</accession>
    <name>A0A0N4UIY5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS1856</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000034">
        <property type="protein sequence ID" value="VDN51883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIY5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIY5"/>
    <dbReference type="WBParaSite" id="DME_0000758901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000758901-mRNA-1"/>
        <property type="gene ID" value="DME_0000758901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9973372at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000758901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41834" checksum="8D0A06B79A5C1E24" modified="2015-12-09" version="1">MCDEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDTGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTYNSIMKCDVDIRKDLYANTVLSGGTSMFPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIAKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ59</accession>
    <name>A0A0N4UJ59_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10109</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ59"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ59"/>
    <dbReference type="WBParaSite" id="DME_0000767501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000767501-mRNA-1"/>
        <property type="gene ID" value="DME_0000767501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5776980at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF136">
        <property type="entry name" value="NOSE RESISTANT TO FLUOXETINE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231511" evidence="1">
        <location>
            <begin position="20"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="2">
        <location>
            <begin position="409"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000767501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="624" mass="69882" checksum="A3440EE9863FA658" modified="2015-12-09" version="1">MIPLSLFLFLVLIPSWLIATQLIDQSGSQAEEVLGESVGLGAGNANPLSTLETLSVRSHQPLKGFGDKADLKPPYNGEQIPAGIYFRISQKGIDYITELAAKALPELLEKAVIPTVEQPQIKISKLTIENFKLVIDDLRQRLLILGVGANVYLPLVTVTAIYDASTFFSTYTGKFKAEIENLTINMEVHISRNEDAKLNIIKAKMNLYKYRSLIEQSVINVLGNEICQIPIKVTHFFEQQKRHILMTTASPQPTTPTPTHLLVYGAKFEESFPTYHTTVEEHGDDDIDEDNPFYNEAEENFSSMMSFEEEEDLAAKFAADLCAEDRLDMGNDVLMSGEQIHLEKRKRSINDVQRLNPLLKEGQWAPDLTLMYPPKFTNEDVVFGLDGGIIFFGQKATNISRPHMLNVSALGDQMFGLLVSEYVPNTFFSHVYNNRLGIIQETFKANNLPKFARLLAKMVCSNCQLQLIANLTSRPELRVDRAGVQLDIEGEIGIIFVAKSKTRTLVNAYTKLDITIRPYLKHSRIYGEVALTGVDIKIKGMGVSGVFSKSIKKALNAVVPRKLWPKIKKRLRFALSQRGIKLPVMCGVELERPSLSYIDHAIVIDTDFSPSNKACAIISFVYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF7</accession>
    <name>A0A0N4UJF7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A-kinase anchor protein 17A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1989</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJF7"/>
    <dbReference type="WBParaSite" id="DME_0000779201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000779201-mRNA-1"/>
        <property type="gene ID" value="DME_0000779201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918237at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000779201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="47214" checksum="0589F1FA7A72CA57" modified="2016-06-08" version="2">MYLSWHRDMPELSFCLDEMEPFFEPLKLYLKPVVLLNISVSLPRLKQAGQSISNRDLIERIKKAIKPTELTSIRICAYTIDVIRFEVELSNRKALTKVINVLDGHSLKVVGCIEPLKIRAAKAKSSFPTRHDWDDFFRNTNNMDQMKPGERPDTIYLSKLPIDWFKDKKNNTLPSEDLLRQIFEQFGAIRCVDIPACDQYRKRMPPSISGIQNSGFPFAEETMFDVYIQFVEYVSFLRAMNGLRNMKLAKMMDNNVISETMIKVGMVDFDKTKHLADDSIQKRQLYRMQLIQEDQKKQQMKEKKEEDKMIKNLVAEKKEERNKRRLEKKESSHLKERQPECEKINTNTNVNCKTNFETDFMQSLLKEHEQRLRQRVGCFGYFLSLILSFFKNSYLILRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJK0</accession>
    <name>A0A0N4UJK0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC2_membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10209</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJK0"/>
    <dbReference type="STRING" id="318479.A0A0N4UJK0"/>
    <dbReference type="WBParaSite" id="DME_0000783901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000783901-mRNA-1"/>
        <property type="gene ID" value="DME_0000783901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000783901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17461" checksum="3D1A1D1E329D146F" modified="2015-12-09" version="1">MQLFPDLEKSVFIMNNENKVLQISLTIFGVASGPVLAIFCLGIFFPFVRKQAAFIGQLSSTFFCLFIAFGSIFEGVRPVPLPLDRSCGSTNISTVIFNASDPHYGMVEPLDSNSYFVQLFRVSYQYYITIAILVAFLVSSIAECTIRLIWGENFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJN1</accession>
    <name>A0A0N4UJN1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10224</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJN1"/>
    <dbReference type="STRING" id="318479.A0A0N4UJN1"/>
    <dbReference type="WBParaSite" id="DME_0000787501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000787501-mRNA-1"/>
        <property type="gene ID" value="DME_0000787501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="227"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="465"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000787501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="603" mass="69849" checksum="868CF3558A3AE24F" modified="2015-12-09" version="1">MGERNVEKLIRRYVDKRDDKLVDVVKRCIRRGYDYEKMKDRVSEHLRDSLSRKKLVDALSEAFPQFARRRKHKFEESKDGEIENNEKKSRFDEKPPKDILVTPAINSTILPVHSLKVEEKSEITEEELRSKELMYQAQMAIEERKRQLNLTARPGIVAQSVISKASKLNTKEASMFVNYSMEKINRVKELKEKVAQRAAGLTTIQKSISNATAKSSGEFETDQKIIEYLDPRIKLKSAQRKQRSIIFHEKGEFENLAHRERASARLALLQSEVAQIAKKTGMSSSVKLAMLTPSSTSTVNDIPEIEWWDEIVLENNDYDSIPDKMLGDERYSRTISNLVEHPIQLKPPDEPLQPQYLKVYLTARERKKIRRQNRKETQKEQTEKIRLGLIKAPEPKVKLSNLMRVLGSEAIQDPTKMEAHVRKQIAERQRKHHIENQQRKLTKEQKTEKKIKKIKEDTSLAVHTAVYKVKSLSHPAKKFKVEMNAKQLHMTGCILLHGNINLVIVEGGPKQQKAFKNLMMNRIKWSDEIIGQKKEAESKDVPGERNECVLIWEGLTKRRTFNEIKILTATLEKQARELLDKHGIAHFWDLAYSTTLLAEDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJS9</accession>
    <name>A0A0N4UJS9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2057</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJS9"/>
    <dbReference type="STRING" id="318479.A0A0N4UJS9"/>
    <dbReference type="WBParaSite" id="DME_0000793201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000793201-mRNA-1"/>
        <property type="gene ID" value="DME_0000793201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="32"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000793201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55421" checksum="586C47B4CB3C04F6" modified="2015-12-09" version="1">VILFYLINYNKICPSICIIVIGSIFAILTTLGNLMVMVSFKLDRQLQTISNYFLFSLAVADIAIGMVSIPLMTYYVAADTKWGIGYVMCQFWLCLDYFMSNASVLNLLLISFDRYFSVTRPLTYRPRRTAKKALTMIASTYIISLILWPPWIISWPHIEGRFTSSDKCVVQFIETNQFASVGTAIAAFYLPLAIMIVLYSRVYCETRKRQLEFSKLQAGAVRSFFRCFWNYIFKMKNRRSCLKICMGKAAASSEESSEVIAANVEETSLTSSTWTHCPSDNSDCITEGNVEHYYTPTRQSKYRTDRSNTYTVLIELNDTKGERPTVRLSSCDSDDLSWFNEYIGGSERGEEISNTEKNAQNGRILRSEPRKSEKERRKNERKQESKAAKTLSAILLAFIITWTPYNVIVCWEAFYKNSIPEAYFLIAYFLCYVNSTINPFCYALCNARFRLTYMRILKCRWHRHHNSSTLTTAGYFLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJU6</accession>
    <name>A0A0N4UJU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2076</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000045">
        <property type="protein sequence ID" value="VDN52103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJU6"/>
    <dbReference type="WBParaSite" id="DME_0000795101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000795101-mRNA-1"/>
        <property type="gene ID" value="DME_0000795101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000795101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8587" checksum="E5E63D2979FE08F2" modified="2015-12-09" version="1">MIGLYLNCRVTYCQPILHLTKRKYIKDMDTAWDTLYPNLCQEGPIINGAGQASLINQGMVNAAKKGKKDNQLYEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULS2</accession>
    <name>A0A0N4ULS2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2651</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULS2"/>
    <dbReference type="STRING" id="318479.A0A0N4ULS2"/>
    <dbReference type="WBParaSite" id="DME_0000876001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000876001-mRNA-1"/>
        <property type="gene ID" value="DME_0000876001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF86">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="65"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="5">
        <location>
            <begin position="556"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="5">
        <location>
            <begin position="672"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000876001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="849" mass="97692" checksum="3E9C8F63AAF044D6" modified="2016-06-08" version="2">MDDLIKNCDNGPKHDGRNVVQAQIKELVQAVQSIEGRVFNDHGDIMSTVVLDEDESDQIYPCGLTGLCNLGNTCYFNASVQALSNCLPLSDFFLSHQSLAPFASLAAQRGKEPPMARSFRLLLQAIWSPRRNGYTNPQQLLMQIRLFYPQFRGWMQQDAQEFIRYFLDTLHQELKQPVYPWEIRDRSNPLLSHEAFHLDSSLLRSHSKIFTYSKGKTSYSRRDSSTSSSNSYNSVETRYETADSGWSSEGDNSSKYKKNRSIEALDTRSSEIPSDPFSSGDITISASNFMERPIRYRSIISDVFDGQLCSTVKCLTCHHLSETNEIFQDLSLSIPTKDQLNHTVAHSSFVKDDATEYKNEKEFTSTSALSYMSIGLQWILWLTSFWLYILYNYLFETPVSLFDALNAFFTPDNLRGDNMYSCENCSKLRDGIKVCRITRLPEILCIHLKRFRHDSSYSSKISTGVTFPLNDLDLSSFMSKSASISDHYAIFDLCAFITHRGGGIESGHYVAYCKNQYDECWYEFDDSVVTKVEAADVATKEAYVLFYQKRQRPFMNHIKNQMKRLVEMEKTGTYKSFKISSNYYISREWLHRLSTFSYPGPITNHDFLCQHSQILPHRAANLTSYCAYVNEDVWIYLSEKFGGGPACSELHYCIPCQKSYLHLRCKRENELKMVKEIKRRVRMTSRSFPHLTYDYYLPPNAISKAWMDKWRDFIKSESIDPPPAIDNSLMLYSDSKSSTIRFRSNSQHLRISRELWLFFVQTYGGGPEVFCVQNVHPSKEEVEQLVNAVDFKIAEAMRSISLRKHTVGADELKLDFLVKNEMELHDVSLKLPDGLSGASDRDLSNCEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMN4</accession>
    <name>A0A0N4UMN4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10623</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001229">
        <property type="protein sequence ID" value="VDN60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMN4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMN4"/>
    <dbReference type="WBParaSite" id="DME_0000911901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000911901-mRNA-1"/>
        <property type="gene ID" value="DME_0000911901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5797019at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000911901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1269" mass="145804" checksum="392AADC10CC3ECEA" modified="2015-12-09" version="1">MSKDSSLKTRLKLLEQLALVMQYRQLQVNTLEAIYHETKDLLLVDEGKDAEVRLLIAIADRQSEQIGLPLRDSFFCDIRQMGLSDLSLEWLVALTKNGEDISGYEYDIVDLILDWLSEVLDIRKLDHRLAIRVLQLAQQMNTGFLREKALDEIVHKMSVRICYKVDHLTYECLLLLDAILKYGHVPDSKLIPLITTLCTVIPFNRLGLTAWGLMKDLLRSSCGYNTLRLLLQMITCAKNCPKPKVIVGAVTAVTLSLWGNQRIDTLRIHPSGVLPALASGMEADPIIMREVFISLKRLLSKYGKELQQLTWHCVMQLLNKAADLLNNMPFSDNRKNLYQQLHKLIKIIEELYREGEFSGSPEAVFDLIERCTFERPPESVVALIDYRIMCISPLTHRWLNILADLVQRYLRNECSIVREKAVSVIHYIFIKYHHMFEIEIISNLVIPILYKVYDEKDMTVQNQMINILFDVAKTMRLLVSGETDLFASIISIIRTFLDIEFHREECSENLEIVIGGVCQMLHERFAHLKFVHLDLIINSIFYDPLKIYYTNENVCKIGVEIRQQLIAALLSILFPIIRGILRRLCRLFEFKDFIFSAGEVRMKKMKDALLNLFEKRAVLLWENDVDVKVDASRKADDRRNDVELAIHLCPVLSRLINYLKDENICKILVECVGAGVQQPIVACSLAIQIVPDCMVPLARQLMNHLTKLQPTSAKLSISILELVSDSSYVREFYQFFQMQDFETIVDILAPCTNVHRFNTYIIAVAFRTLMRWYVLIPENYRLRMAEYIINRVDLHLLSHIIPLNDLVQLANLEGRSSVSSISTFGSQPDSPSLSSVLHTLPSNRNSNYYGTVEASQRESLAEEARQALLTFMQRCKSDSVDKTIHPADLTEMTEYRTEHWVINDTIISLSVYLDNKPWKESDSSESERNIQLNEEFTAEGRRRHQSAVQRPEKYVVKPLCPTTLDDSFTMKRQAPKRQIQTLAVWTQLTIRHIYGKHSWLMRGLIETLEDFNASAQLLNIEDSSELIMHLCRGGNAVKITSTDKAKISRSLRNLDRIFALEVHCVGIVYIAPGQTKESEILSNLYGSERYSSFIRMLGEPISLEIHPGGLVPEIHGNFTYRYTDALSQLIFHIATLMPRREDDPQCNQKKKFIGNDYVSIIYNDSGKSYELGTISGKFAYVALEVVPLDESHMQIVIHTRQEIASWLSITRAFLPDEQAANFLKCLILRSQLSVNVWRREDENGPPYIGLPVERMRAIRNFATMGTKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMV5</accession>
    <name>A0A0N4UMV5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2942</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000091">
        <property type="protein sequence ID" value="VDN52969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMV5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMV5"/>
    <dbReference type="WBParaSite" id="DME_0000920501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000920501-mRNA-1"/>
        <property type="gene ID" value="DME_0000920501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11790">
        <property type="entry name" value="SH3_Amphiphysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF3">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000920501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19157" checksum="CD2701635BA5D13E" modified="2015-12-09" version="1">MIKVTLDLQQAESIFQELNKELIDTLPATYDSRITFFVDTLQTLLNAENINHNECEHKDKSEDFESGSVDSREKSTNPFDDSDDDAAKAVETIKIDASGASDIKSRKVLYKVRATHKYVAEDTDELSFDAGEIIFVLKSCEEDLLDDGWLLGQKQSDGSRGVFPANFTKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN35</accession>
    <name>A0A0N4UN35_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3021</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01000097">
        <property type="protein sequence ID" value="VDN53048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN35"/>
    <dbReference type="STRING" id="318479.A0A0N4UN35"/>
    <dbReference type="WBParaSite" id="DME_0000929901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000929901-mRNA-1"/>
        <property type="gene ID" value="DME_0000929901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000929901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36468" checksum="3F53ED0135E0195A" modified="2015-12-09" version="1">MNSYYQSLNVDGRFYLREKLGYGSFGEIHIAEDKITKKRVAVKVEVCLSPTHRLITEKEVYECLNSSNDESMVPKAIWFGTLRSYKALVMELMGPSLETLFRLCDRTLSFNTIAYLGIQMLSCLEFLHCHSYLHRDVKPSNFVMGVGINCNNVYLIDFDVAKKYRDERGNHIAYEEQKDFVGNAKFASLRTFLQQGLSRADDLESLAYILFYFLMKDLPWQEGDRNNRQKMIDLRLRLTDIYPSVPSEFKRFLSVCRTMHFDEEPNYVKLECLIWNRETVLHKPVFEWSNLSSEKMKLIESGKFEADFSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN56</accession>
    <name>A0A0N4UN56_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3046</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000099">
        <property type="protein sequence ID" value="VDN53073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN56"/>
    <dbReference type="STRING" id="318479.A0A0N4UN56"/>
    <dbReference type="WBParaSite" id="DME_0000932401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000932401-mRNA-1"/>
        <property type="gene ID" value="DME_0000932401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6019271at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000932401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9706" checksum="D1477D42DF2A15DD" modified="2015-12-09" version="1">MWTRSEVETSTIHDTVAELQELIDEMRLQDFDSIRFATYRAASKIRFIQTKTNVHLVDIWNIIESFRENGLNALPVTSQDAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNJ6</accession>
    <name>A0A0N4UNJ6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS3156</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UNJ6"/>
    <dbReference type="WBParaSite" id="DME_0000947901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000947901-mRNA-1"/>
        <property type="gene ID" value="DME_0000947901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000947901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="27770" checksum="07AB787B4EBAC4A1" modified="2016-06-08" version="2">MNKKKNLQGLVALITGGASGLGKGTVETLINHGLKVAIIDLPSSAGAEVAKVYGENCLFTPANVTSENEVGAAVEVLHKKFGRLDVNVNCAGIAYARKLYSVMKKQMQSLDEIERTLKVNVIGTLNVIRFACQLMAENEKDEAGQRGVIINTSSIAAFDGQIGQSAYSASKGAIASITLPLARDFAEDGIRFVAVAPGIFDTPLVNCLPPKAINFLNNLVPNPKRFGNPVEFGALVHHIIENRYLNGEVIRLDGALRMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNK0</accession>
    <name>A0A0N4UNK0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WASH_WAHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3160</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNK0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNK0"/>
    <dbReference type="WBParaSite" id="DME_0000948301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000948301-mRNA-1"/>
        <property type="gene ID" value="DME_0000948301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883432at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008064">
        <property type="term" value="P:regulation of actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033378">
        <property type="entry name" value="BRICK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668:SF1">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000948301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14932" checksum="B69E8B8CF468FABE" modified="2015-12-09" version="1">MNVGHLAVSLVQRQLREDWDNREYAQVISDNIKHIADFLGNFELSCRSKIAALNDKITVLERKIEFLEAQVDSFHIFPFCSLKSLLILGYSCISFRDFMCNLFMELKTTILLFFYLFYIIVNEAFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP02</accession>
    <name>A0A0N4UP02_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS10720</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001239">
        <property type="protein sequence ID" value="VDN60747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP02"/>
    <dbReference type="STRING" id="318479.A0A0N4UP02"/>
    <dbReference type="WBParaSite" id="DME_0000966801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000966801-mRNA-1"/>
        <property type="gene ID" value="DME_0000966801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02983">
        <property type="entry name" value="P5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN60747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000966801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46492" checksum="EF061043D8A5E27B" modified="2015-12-09" version="1">VVGVCVAFYDNDLDVIELTDSNFNSKVIGSNDVWIVEFYAPWCGHCQSFAQEYKKAGKILKGFVKVGAVDATKYSSLSQRFSIQGFPTVKIFGSNKQKPIDFNGARTAQALSDASISEIRKVINSRLGVKTDSGSSGGGTGGGANKVIELTDSNFDDLVLNSKDIWLVEFFAPWCGHCKNLEPHWRQAAAELDGKVKLGALDATVHNVMASRYGIKGFPTIKYFAPGSSASDAEDYNGGRSASDIVQWALEKAAENRPAPEVLEGIAQTVFDDACKEKQLCIIAVLPDILDCQSKCRNDYIQVLKDLSEKFKKNLWGWVWVEATKQPELEEAFGMGGFGYPAMVAVNYRKMKFSMLKGSFGKTGIHEFLRDLSYGKGQTAPVKGAEFPKIRKIQPWDGKDGEMPVMEDIDLSDVDLGDHKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP94</accession>
    <name>A0A0N4UP94_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3382</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000128">
        <property type="protein sequence ID" value="VDN53409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP94"/>
    <dbReference type="STRING" id="318479.A0A0N4UP94"/>
    <dbReference type="WBParaSite" id="DME_0000976601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000976601-mRNA-1"/>
        <property type="gene ID" value="DME_0000976601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF4">
        <property type="entry name" value="NAD(+) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000976601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33670" checksum="6D598F578292ABC3" modified="2015-12-09" version="1">MGRRDHFIETRVVSGDEYLTENVEWADAVFSVGGDGTFLMAAAKVTGQKPVIGFNSDPEGSEGHLCLTGKSFHSVSEVISDLFKGKFSWIRRQRIRVTLLKVVNDERLSSESDDNENGRQINNGSFRAYNPGVPLLALNDVFMGEIHAARVSSYDVQIDNNPVIRQKSSGLTVSTGTGSTAWYYTINRLSAQDVGEILSIVNSMGLMNIEVNDQQNKEISERFSQNLLFDPSSPEMAFAIREPVYNKTFKEIPPRGFAKRIFLKSRCSDGQLVLDGSITVPFNEGSEVLLEIFNEDALLSAIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPQ0</accession>
    <name>A0A0N4UPQ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DME_LOCUS3498</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="UYYG01000141">
        <property type="protein sequence ID" value="VDN53525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPQ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UPQ0"/>
    <dbReference type="WBParaSite" id="DME_0000994701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000994701-mRNA-1"/>
        <property type="gene ID" value="DME_0000994701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000055">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="922"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="114"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="775"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDN53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="DME_0000994701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116492" checksum="DC58D6E1BF77E237" modified="2016-06-08" version="2">MENAHTKASLFSSAGLSEELLNKLYSFAELPAEEGKKLWELILEQFDDLLVKILLLAAIVSFILALFEEHDDQTSAVTAFVEPFVILLILIANATVGVWQERNAESAIEALKEYEPEMAKVIRSGKHGVQMIRANELVPGDIVEVSVGDKIPADLRLMKIYSTTLRIDQSILTGESVSVIKHTDVVPDPRAVNQDKKNCLFSGTNVASGKARGIVFGTGLATEIGKIRKEMAETETDRTPLQQKLDEFGEQLSKVISIICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSKMFTAYSTSGDDIQFTEFTVTGSTYEPSGQVYHNGRQVNCASGDYETLTEMATICSMCNDSAVDFNETKRVYEKVGEATETALVVLVEKMNVYNTNKSGLSPRDLGNVCNRVIQQKWQKEFTLEFSRDRKSMSAYCIPSSGGSAAKMFVKGAPEGVLSRCTHIRVNGQKVPLTAKMTQRIVDQCIQYGTGRDTLRCLALGTIDNPPSPQGLDLEDSSKFIRYEKDITFVGVVGMLDPPRSEVIDSIRECRHAGIRVIMITGDNKNTAEAIGRRIGLFTEDEDFTGKSFTGREFDDLPPEQQSDACRRAKLFARVEPTHKSKIVEFLQSHGEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASEMVLADDNFATIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLVAALGIPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSASESLISKWLFFRYLAVGTYVGVATVGASMWWFLLYEDGPQISYYQLTHWMRCEIEPENFTDLDCAVFEDTHPNAMALSVLVTIEMANAMNSLSENQSLLVMPPWTNVWLMSSIALSMSLHFIILYVDILATIFQITPLSWAEWMAVLKISFPVIVLDEILKFIARNYIDGEQDSKSTEDAKFKRLFLLRAIFSVVCLTLLWISYFCWILIPYVPQFMHAIGRGPRVSNNPLYSVFRSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPX9</accession>
    <name>A0A0N4UPX9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3568</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UPX9"/>
    <dbReference type="WBParaSite" id="DME_0001004101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001004101-mRNA-1"/>
        <property type="gene ID" value="DME_0001004101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849055at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001004101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11304" checksum="E62B0A4E18F33B16" modified="2015-12-09" version="1">MRKLREVNCNKRVYYCQRCLNHNRLEPRKNHKCDCIYANCTCNKCILVEKRRMLNIQLHELEEIADNEINDIEDIDDNYNKIGNKIKGGKFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ54</accession>
    <name>A0A0N4UQ54_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3652</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000162">
        <property type="protein sequence ID" value="VDN53679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001012201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10823" checksum="0D08B8291BAE0132" modified="2015-12-09" version="1">MGTACRYSRSVQISQEHSIIDLEYADDVVLFADSYDEMQVMLNNVSETTARIGLTINVVPDFKYLGSTLIPNGQAKDDITTRITAGRNAFFRLTKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQC7</accession>
    <name>A0A0N4UQC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10853</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="protein sequence ID" value="VDN60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DME_0001020801"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="8"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001020801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23423" checksum="17154A8630305E82" modified="2015-12-09" version="1">NCSCGIIVNLCLITVIWKTGLIKKPFGVLSISIGSLNCSIVLVTSFYNLITFSFEMLINSFQLNRRQITKEKSANGIGQLINGIYYSNLLLHLLISVNRFYSVAFPLKYGTIFDRKKTKIMVFLIITIWSLSSFLLCVYIAFSWFINLNLPYTTAAFALLRTSFRSRMLIFDFLDATLIAPFCTTAWGTFILFTFTWMLCHFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQI6</accession>
    <name>A0A0N4UQI6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3771</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000184">
        <property type="protein sequence ID" value="VDN53798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQI6"/>
    <dbReference type="WBParaSite" id="DME_0001027501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001027501-mRNA-1"/>
        <property type="gene ID" value="DME_0001027501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001027501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8095" checksum="C8FAFC2F6DFEF0D4" modified="2015-12-09" version="1">MIDSIKPIKERLERPLHEVTALDIKLPEPSLTNCTKSKDDCSKKKSCNCKCASSQSNQRMTNGLNIHINLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQN3</accession>
    <name>A0A0N4UQN3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3820</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000193">
        <property type="protein sequence ID" value="VDN53847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQN3"/>
    <dbReference type="STRING" id="318479.A0A0N4UQN3"/>
    <dbReference type="WBParaSite" id="DME_0001032701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001032701-mRNA-1"/>
        <property type="gene ID" value="DME_0001032701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062876at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001032701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19382" checksum="E72553BB18CDF5C8" modified="2015-12-09" version="1">MFYIFIFHFRLFFVGAREGHMPLVLTMVNKDTRTPIPAVIFTGLLSIAFLSLSNNIYSLINYIQIVYWLAIICVIAALLWLRKTMPNAERPIKVNLFFPIIFLIGCIALVVIPIIGSLKDTAIGIGIMLTALPVYAVFIARGKPPKFLEKISSSLTTFIQKLFIVVDDSKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQQ1</accession>
    <name>A0A0N4UQQ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10880</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001265">
        <property type="protein sequence ID" value="VDN60907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQQ1"/>
    <dbReference type="WBParaSite" id="DME_0001035101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001035101-mRNA-1"/>
        <property type="gene ID" value="DME_0001035101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850978at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001035101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23156" checksum="718F6B7B7499BBA7" modified="2015-12-09" version="1">MENDLEPLMIANTDRNTRNNIARIWPCGKCSILLGLCHLFIGIFLLIFDIITNNISEIAFAATSSLTFIVCAILAFIASNLKCEIFFRRLDRTSQLLLLFISLFAIALTIIMFIDSVVVINHNCDLNNCYQRKNIIYFVILSISLIELTICLITLFVCFRSLRKAYGVTKARSPYSTLIEGNYQLFKIIPRLFKFFDDINKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR07</accession>
    <name>A0A0N4UR07_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3931</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000221">
        <property type="protein sequence ID" value="VDN53958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR07"/>
    <dbReference type="STRING" id="318479.A0A0N4UR07"/>
    <dbReference type="WBParaSite" id="DME_0001047301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047301-mRNA-1"/>
        <property type="gene ID" value="DME_0001047301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41536" checksum="83A1971D4399747B" modified="2015-12-09" version="1">MKNINITLSKLAVSDDSVLVGNSAYNTISLPQINGSTRTEKVHKKVLEFTMIFFILEGMTGNIAHICVRENQYKIFHGQLEERQFRLCAIKFFQSATFKYSRKPNIMVTVEYSTKPFHTLHLSIVKNKLADQSKSLIFCSCGWSHKDFQTLRLYGYNEKSTLAIIHNEKKIPYPTAIKSEIRQRRPFCNQNHWECQVHQGNECKRKLLIVVPYAKKEVDHMRTKGYALTRIKQTKNIKLEDYSTNYNLTTITQTNALITIFDQSQPERKEETLAPFEHWLSVLETLNYLEPFRRNSVYELRKMRTFDQQIKIPMANQTMNLKNYWRRPDILTGADHFFKIVQLNKIEKLKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR48</accession>
    <name>A0A0N4UR48_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10922</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001276">
        <property type="protein sequence ID" value="VDN60949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR48"/>
    <dbReference type="WBParaSite" id="DME_0001051901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001051901-mRNA-1"/>
        <property type="gene ID" value="DME_0001051901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033232907" evidence="2">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001051901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18380" checksum="BFD43A7270DAF103" modified="2015-12-09" version="1">MFTFLLVLASLYNLANAGAADIDVCSVLVPVVAGGNQAAGAQFVRRPSVPVENCYDRDAPACFEIFKYANNEMQIIADNRVPTNGYKVPENCQKDAYKMLVRQMCPHTCATCCLTKEYNCQNATSISPLTSVCRDERLNCAAVRAANSCGGVFRTTMMQQCAKTCGYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URJ0</accession>
    <name>A0A0N4URJ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4089</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000282">
        <property type="protein sequence ID" value="VDN54116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URJ0"/>
    <dbReference type="STRING" id="318479.A0A0N4URJ0"/>
    <dbReference type="WBParaSite" id="DME_0001067201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001067201-mRNA-1"/>
        <property type="gene ID" value="DME_0001067201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9946071at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001067201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8160" checksum="E269278DCF691D25" modified="2015-12-09" version="1">MEDFATYKRRHEGYRCICEWGYRSTTNTSNPYCEDVDECSANPCFPGSACINVPGSFIYILLYKQLTIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URX3</accession>
    <name>A0A0N4URX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4206</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000404">
        <property type="protein sequence ID" value="VDN54233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URX3"/>
    <dbReference type="WBParaSite" id="DME_0001080501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001080501-mRNA-1"/>
        <property type="gene ID" value="DME_0001080501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001080501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7953" checksum="43E92F31CB7A4DEB" modified="2015-12-09" version="1">MPKNMFLKRLPYKSTRDTWEIVKSNTVAVPPAGSCRDEHADCPKYRNLCNIGDYATHMRVKCRMTCSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q318</accession>
    <name>A0A158Q318_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5816</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q318"/>
    <dbReference type="STRING" id="318479.A0A158Q318"/>
    <dbReference type="WBParaSite" id="DME_0000145601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000145601-mRNA-1"/>
        <property type="gene ID" value="DME_0000145601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9355041at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="69"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="165"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000145601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35114" checksum="13668D89F71B110F" modified="2016-06-08" version="1">MCGTLNRGFPIVIPSSKEFVVAADEVTVPKLTKNYQNKTIKCLAVQDFLEYHTSTIEEHEIKIDVWFAPEFQSPIIDKYAIVGRSASLICEITASNPPAILFRFFANSNQLNNNDKFEIISNISKQIAILRINKVDEENFGEFKCEVSNIKAKSYQIINLKESSAPGEVHTSLYEVGNRSLTWKIDDDEVDLPTTAYIIEYINKAYIDEITGPNENIEQERLWNSLSMHIKFNKLKDGSYIVDGLQQDTKYMFRIRAENEAGQGDAITIIASTAKHDNKVQSIMANLSLSTNFNFFLSFSIILATILMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3P0</accession>
    <name>A0A158Q3P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS23</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0598 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3P0"/>
    <dbReference type="STRING" id="318479.A0A158Q3P0"/>
    <dbReference type="WBParaSite" id="DME_0000279401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000279401-mRNA-1"/>
        <property type="gene ID" value="DME_0000279401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260024at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028108">
        <property type="entry name" value="DUF4505"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449:SF3">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14956">
        <property type="entry name" value="DUF4505"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000279401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="27137" checksum="C224B81B4BA75278" modified="2016-06-08" version="1">MVTFDRRILLQFSRQISYKQGQIIGKHREYFYFIDNNGQLFLDDMKIKNFTSSYKGLCFFSYSPLSDKKTIIITIFIHHFLKSFLVQYIKVTFFHTILDTQFLDFFFTRLKLNETDRYQKEFPYVSLCGREMNFLRCGDRPVVFTSLNADDDSWNICNCTLKVPFKPEYLCMFANGRLYHPAALDKYGLVKSKLSSDIFHHFIFDDDEQQPTHFKWKGTIIKLKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3P1</accession>
    <name>A0A158Q3P1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Signal peptide peptidase-like 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS36</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3P1"/>
    <dbReference type="STRING" id="318479.A0A158Q3P1"/>
    <dbReference type="WBParaSite" id="DME_0000280701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000280701-mRNA-1"/>
        <property type="gene ID" value="DME_0000280701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041047431" evidence="8">
        <location>
            <begin position="27"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000280701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69309" checksum="D47450D78C74F011" modified="2016-06-08" version="1">MVIVGSVWHMLLLTLFQLIFIVFSEGRKDKTHYESSYVYMLVKNEISGKERQFCVNYQQWRSDFIAESAIQANAVELAWWGGIVGNTNVCASNTSVNYAGKAVALNYRITADDGRCAAPFVISNMSFKGAIQYEVDQLISQEASVALILVDRGRHFVSRWFDYLFAEFYDPDLNTTLPTFFIYKNVFLNDLLGLSTNKTGKDLTIKFYRPLYSIWDWSMLIIWLLAVFCTGVGGFWTGRTIGDEVSQKIHRIDDTQAKKDSYDKETINSFATCVSIALVMLIVIGVLMLGFFFRPVMVFVFNMFLAIIGIFSIHRCFMTVIQRYCKSTLSYGCSLHEMAQTIFRRELLHINEYFLSRSFILSVIVFVLSTFICVSWFIFRRSPYAFILLDFINVNICLYALKGFRFSCLKWLTVLLICMFVYDIFMVFGTPLLTRNGCSVMIEVAAGTDCSKSQGVYPVAPINSDTPEMVMLCHFPMLFQVPHLREPLISCIDLEVEKDFHPVFLGLGDVIVPGYLTSFCFMADLAIGTCYLYGIVSLQHIFPQFIGYGVGLLMTFLALTLMESAQPALIYLIPFSLLPVMVLALIRKEFKILWNGLFEFKNVILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3S2</accession>
    <name>A0A158Q3S2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">XPGN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7208</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3S2"/>
    <dbReference type="STRING" id="318479.A0A158Q3S2"/>
    <dbReference type="WBParaSite" id="DME_0000304901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000304901-mRNA-1"/>
        <property type="gene ID" value="DME_0000304901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF59">
        <property type="entry name" value="FI23547P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="7">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000304901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56211" checksum="C555D878A2593292" modified="2016-06-08" version="1">MGRGLWDVLGKYREPVDISALKNKRIAVNGHCWLWEIMRGNVANCSSTLKPHLSTFYNRCQALMDYGIEPVIVFDNVENSIRHDPQNNTVLKKDRKNRSGIWAKELRLEIINQIREIKILLNAMGVRFMASKLEGEAQCAQLEQRGLVHGCITRSIDYILFGGTNLYQVEFSSSGRSIHNSILVLSMNRISDQLCINRSALIAMAFMIGCDYYTGGIPGVGAVLATEILSEFYVMKQDHPQVILDRFISYVTGAVPVREIDSDLKRKLKEKCQRNLIDIRCLHPNTDAFSNLINAYFTPSVIEYSRAQLPKKGSIDHSKVQEFLLRECNWDPMYAELVENNSPNKQTKDRNIAILRHELSTAICQASQRSCSKREILAVERLHSMAAEYRFVPNVEIISVPATSDDMIKNEQKVENNSNNANNRRSTKRKTNMVSADEPSSKVSARKPSGITSSPLDMKDGQRQATTDVEDNSKGLENGLLNTDEVSCAQTLHVIPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q407</accession>
    <name>A0A158Q407_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7730</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q407"/>
    <dbReference type="STRING" id="318479.A0A158Q407"/>
    <dbReference type="WBParaSite" id="DME_0000372501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000372501-mRNA-1"/>
        <property type="gene ID" value="DME_0000372501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919042at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20814">
        <property type="entry name" value="CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="798"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="9">
        <location>
            <begin position="965"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="570"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000372501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1293" mass="148833" checksum="924255744A8622D9" modified="2016-06-08" version="1">MHSVSRSTEGCEEGECSNSLSKDGRGKSADIIFLEETIQKQAELIQEIKGELLNGIEMEKDEILLTRNKILEQEIRLLRCTIRQLKKELTEAKQLSLEACEVYQKEKKSYLNQKEEMDKRQEQLSKTIDSIDHLQIELARANRQINMQDSEARQQLLNIELQKERMQDAKKIVSLQSKVHSMKQKEELLSNELGEVHKKLEICLQNQIKGLESFVGHSKFDEKDVNTDISGNYQSDFRENHEKLMSLMETLQKQIESIKSRKAISQEQSELYKQIGCFTTKILYLEKEIAEVNQSKDIVMADLKKSNEEINYLKSELQKAEKKLSDSEKNFDIIHRSLMEENGKIKLQKAQLRCDLIDLKRKYFRLQNELTYGQGDEASHAQLKISEMANINKCFDKELGLFCGTAKCSVLSIENVSNSTVEGNQKEAKFKLCDINLSPVHELQTPGEKNCAVEMSFKMKLEHCNKELTTLKASYNTDINMLKKQLLVAQEEKIELSNALQFIDVQCERLLENKNYLEKSLNTAIHELQDIKTKLSVAEHHLASTNELKAQLKEITFEKNRLLTKVEYLTEELRETHNDYREELARITQQNEKLRAEKHYLNTMIKSLERQLEQKNNEFTHLNKDLAELHDSHAKIIDENKKLRNGLALSIEKLEKYRDELENSKSLNANLEENLRKTKDNEDCLKSRLDVMVQTVDEKDRLIAYLQAQINLKGSLKLQRNSSHSTLMSYDDGLFMFFSVKIHYDRETSPIISLVNDDKKHYTAPTSTLSITTQYISNDVPLSPSSAAHIGTMKHDIPHRWKNYFNLKQAKCVVCLEGLPRLRHSLKCGECDVVVHRGCSFSVANTCGLPIQCADYYLDAYQKNNMNMSGQAIFEIDLNQEQWRIYMQPASETVVKNSVSPESYALLIELRIKRCNLFVLAPTIQAKQRWLQALQAATNRRMFKQRRSVSFSGSIMLLALDAPLNLTIHCSKVIENWLLLGTQEGLFVTQINPMHIPFTVMGITAVYHMELIEELEMLAAICGNQRQLVFIHMSDLKAIFKSNGMAIRATPLANVTSCHIMTLYSDSVNQLYFLFIADACKIDILQFNSRLSIFTQFDSLQTKEPACCLLSVPGGLIYGADQFYFVDIKTFVVRPLLIANAHVDWPRAAAVIGNNEFLLAFHNFGIFIDIDGNKTRTEIIDWSRAPLEFVYAAPYLYVVHLETLEILKLAEYEGLNSKTLLDERDVFRCKNAHFIGRGRHDEVLFTLSDNDRTEIHSFCKGSESRNSTMFLKRKNINNDNIIRFVNSGKRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4G0</accession>
    <name>A0A158Q4G0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8658</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4G0"/>
    <dbReference type="STRING" id="318479.A0A158Q4G0"/>
    <dbReference type="WBParaSite" id="DME_0000477501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000477501-mRNA-1"/>
        <property type="gene ID" value="DME_0000477501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803581at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000477501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49465" checksum="0C82BF25A004094E" modified="2016-06-08" version="1">MSLQAAFEILDIASYLLIDPILPVISDLILKKINAKSLVLAFHKAEYRYVPLAQRLWKIIVQEFDKLIMNDTFVRLTEDEILKLLTDKYLNIKRCDETAMVRRWLSENANNGNNGRRLKAMLADKCDRLGFMENETRIPNSILLATGGWSAIGPTMLVESLDVRSKRWVRSEIKLFEISRAYHAVINMGDALFTIGGFDGNEYYRSTRKFDLATMQCVEVAPMYDQRCYVSCAQLDSERLIALGGYNNRERLKSAEIFHIPTNQWHRIADMDKRRVYAIGGFDGINCHSTVEFYNEESNHWIDINIMRCPRSGVGATSLVGAIIVCGGFDGRNRLRSCEFIDPREGNWHRIRSMNRPRSNFGIETLNNEIVVVGGYSGIIGTINEAESLDIRTNTWMQLPSMNIRRSALYLTRIDYHEIIEKFIRPKNGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4S9</accession>
    <name>A0A158Q4S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein DPCD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS684</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4S9"/>
    <dbReference type="STRING" id="318479.A0A158Q4S9"/>
    <dbReference type="WBParaSite" id="DME_0000563901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000563901-mRNA-1"/>
        <property type="gene ID" value="DME_0000563901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819442at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20237">
        <property type="entry name" value="PFM_LIN24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369:SF5">
        <property type="entry name" value="CABIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000563901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29906" checksum="3E7F194DC7E199F0" modified="2016-06-08" version="1">MCQNHVDVDGLLEDYAWRHFKDVQSIRKTRLDDYKNLERDDVEFILNRKKLIVTHGEPSYTQFHATGARPYTLFKSVYTNNTDRSQEYSFKTERTTESMCCVVREQGYSLGGETELTLKTPCEIAELKAGFKHEMHFNNMNENTKCETLSWGVDSNVVVPPHYITEASIIIEEMNYQGSYTVMTQLSGLVTISIRRRKDGALILPLTVNIVEVFREHLESRNVRKEIRTSAMVEGNNCVRITSKGKCQFQRQDSKMVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Z0</accession>
    <name>A0A158Q4Z0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS995</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Z0"/>
    <dbReference type="STRING" id="318479.A0A158Q4Z0"/>
    <dbReference type="WBParaSite" id="DME_0000605601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000605601-mRNA-1"/>
        <property type="gene ID" value="DME_0000605601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="74"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="268"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN51022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="DME_0000605601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="726" mass="83215" checksum="748548A108A120D1" modified="2016-06-08" version="1">MSFFYFSTFRSRSRSRSPRRRDRSRSATPDTRNHLEKPIAHSNPYTGHPYSTRYWDLWKKRSTLPVWEYKEKFMEVLQANQCLTLVGETGSGKTTQIPQWCLEYCKSRVVYGGQKKMVACTQPRRVAAMSVAARVAEEMDVQLGSEVGYSIRFEDCVSERTILKYCTDGMLLREAMNCPLLDNYGVIILDEAHERTLATDILMGLIKEIVRQRNDIKIVVMSATLDSGKFQNYFENCPLMSVPGRTFPVEIFYTPEPEKDYLEAAIRTVIQIHICEEIEGDILLFLTGQEEIEEACKRIKREIDNHGAEIGELRCIPLFSTLPPNLQQRIFEPSPSKRPNGAIGRKCVVSTNIAETSLTIDGVVFVIDPGFSKQKVYNPRIRVESLLVCPISKASAMQRAGRAGRTKPGKCFRLYTEKAYKVEMNDQTYPEILRSNLGTVVLQLKKLGVEDLVHFDFMDPPAPETLMRALELLNYLAAIDDNGELTQLGSLMAEFPLDPQLAKMVIASTELNCSNEILSITAMLSVPQCFVRPTEAKKAADEAKARFAHIDGDHLTLLNVYHAFKQNHEDVQWCFDNFISYRSLKNADNVRIQLARIMDKYNLKRLSTDFKSKDYYLNIRKALVAGFFMQVAHLERSGHYITVKDNQLVQLHPSTVLDHKPEWALYNEFVLTTKNFIRTVTDVKPEWLLQMAPQYYDMSTFPECDAKRKLMQIINTMNSLRNQRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q525</accession>
    <name>A0A158Q525_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1205</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q525"/>
    <dbReference type="STRING" id="318479.A0A158Q525"/>
    <dbReference type="WBParaSite" id="DME_0000630801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000630801-mRNA-1"/>
        <property type="gene ID" value="DME_0000630801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="60"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="417"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000630801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="51623" checksum="73502D8803C2B8B3" modified="2016-06-08" version="1">FQEINKNAATPSLRIGRKRKTAEIHDSKSTSGLFFIKGTRTGRIRLKYENYLPKEFGDRVLSCGEGEQLGHPGRLATRKPRAIDSLPEGKKIVQVVAGGVHSVILLEDGSIYTCGINEKGTAPAEGVEAEGSSDHLAPIIFANLISQHGKIVMVAAGASFSAGLTDKGSVIAWGNLRGTSGCIESHKILVEMEEHPVVIIDHKNRVIVKIAAGENHLVMLSQYGELLTFGDGSMGQLGRSVRLTSIRSQQMVDDSGISLLVSVKEKRKQKLVVFNDIMAGGYWTAARATDDRLFVCGLNNFGQLGVDLPEMDQLAKPEPELRIMRPTVAVAFESYKINQLSGIHHIILLDDSVDFNLFLGDVYGIGKNTDNALGIGTWTGKDDDDHWRYTKPQKISLPKASGVCAKLGCSVAWTSEGVAYSWGYDTSGQLGLGIKDDVDKIVPFPRKITSAHLDGYHILSCSIADNHTLFLAKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5P9</accession>
    <name>A0A158Q5P9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2066</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000044">
        <property type="protein sequence ID" value="VDN52093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5P9"/>
    <dbReference type="WBParaSite" id="DME_0000794101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000794101-mRNA-1"/>
        <property type="gene ID" value="DME_0000794101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5832220at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000794101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27423" checksum="6DE38FC0503EA12D" modified="2016-06-08" version="1">TIIGIYLLLLLLLSLLFVIFIITVLLLQVTSTSMNSIVIRMIGINDINYFNMFIEIYDLDRQINFRQTQFISKNYDQDIIVQTKNNSKINQSIIFDQIVFINNFTSNDDQLSISVKTIFEKYDKISTVIVPELHCSHMVLQPAAQLIMNNTQIHFNFNNFNKNDNLESLNCTYLCLFPYLRLIINNKTKTFKAREFCNNLHQIYFNNSCIYYFYNYFIFLFINLFFIVAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5S8</accession>
    <name>A0A158Q5S8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF3677 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS10265</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001209">
        <property type="protein sequence ID" value="VDN60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5S8"/>
    <dbReference type="STRING" id="318479.A0A158Q5S8"/>
    <dbReference type="WBParaSite" id="DME_0000812901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000812901-mRNA-1"/>
        <property type="gene ID" value="DME_0000812901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19938at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053964">
        <property type="entry name" value="INT1_R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053966">
        <property type="entry name" value="INTS1_INTS2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22927">
        <property type="entry name" value="INT1_R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22929">
        <property type="entry name" value="INTS1_INTS2-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="2">
        <location>
            <begin position="281"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 INTS2-binding" evidence="4">
        <location>
            <begin position="884"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R3" evidence="3">
        <location>
            <begin position="1520"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000812901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1687" mass="190327" checksum="46B7771541816C04" modified="2016-06-08" version="1">MNKHTTKGKANQPAGGFVAIGREGPSTSSDSIRLKALGTKRDLPQASGGILKKARLNFSSKTIVASSINSSFKRYEHDETKWREFCADVTIDARTILNSLESAREKQKFQKIAKLICATLREIIQHRLSSGGWCGEPLILSSIAIFIKENSEIFAQQSEVISALCSVLSTNFPSTSPSYVFIPSILQSILKNSTDWNWSLVDCFIDDSLHERHWVDHSLFSVFVRNILTAFGTRIPSESMYSVCELNYPEHFRVSSTIKNRFEKNAAKLEAFASQIREICERKAESSPRNLLKTMCACSGLSQVRLLAARKMDSWLLNGKLQRYAMELLLWIARNMGHEEYNEDDTETLSALLKLRALKSKQINTLFNVALKFELAHQLSQLLGAKEEYLRISRTFLREFVRSLLRLDFDFALFAQHLFEAIVEHVTPATVPNYLFKSLIEFCVMLPFVAISATVREAAQLRRSTNANLTQIQIDTLLRFYKDLRRFFEISVKFLISSHELCNDKKLFVFSFYRLLYLAGAEFYFLIDNWPIEADLTQYLRIISEAPSSETLVCSILEAGWDPLVPIDGADAIDLVENLTKRAFLCTPVIEGMAMLPICKQSSIEKLFKAAAYRPPPAFQLKDIYDDDAPNLAVKTLYWKGWLIALLWVSFNKGELIKEACYKFPTLKIIIQMILTWEYRFPPSASINEEMTAEMFIANDEQKLKEERQMIKQLETRLAGGEVSERDSKLLGKLCSLDPTGFCRRSPDSFLRDLEKLNEDFDLSRLLCECREPDLLADIIRSQVQFIIAILEKVFLMFVPVFFQGSVRALPSLINLVDSNANAIVHLPLECICELFLHYISAQSGSKPPNIEKLNTLRCRLHNSLKGPFATETTVMETFGCLSTRLASVIASERDNAAHCLTLLLQADICAPIFPVNGNASPAPFLSSVAFFEALKAKISVIIAKLCPIETHACRLSDYVDFLSNNFDSSTLHLIAYHLSLMVEHLNDDETQLKVRTSALSFYDTYMKRIEIDKGIWPAEFESLSFNKARRVLVRFEDMHKGTMFVETISCVVSGILQLLCGKFDENVDKVRRDLMDIWFPSDGLGPKVSNTEGIEVLPSWLKLKMLSTSDERIVRNALHGLQVIDALKFVQCFALTSYSCSKLFSILDNIDKPLCGEILDEGNNAAAYIRAYKLRGAKGGDKFLQLLADGLQKNSNVKMEVDEYNVCVSIDPPPSFSTGSTSLELYSSELSVEEVVKYVEDIKSMDKNCFKVVRTISNNAVCAARLLTLFKRKPLLLSHSLVASSILIAIGSLISKHPSIRDDIRSLFTSIEKKASVPDAIKKILQNFTGGFGSTTDKQQKPKTKLDAESILKALNDSKISVDAEADLIEKYFSVCPELIPLSNQSTDGACNLSSCRLLDLLFSHSSSSLDRIISLIPTVCSPGTISKIIVYLLYSHRSEISASSVIRAVMENLHLANPPVMNRSRCTVLIEYILDEVERDESCVKALIRFLENVSKWDDIEIKEDQIILHSLRTVDTLDKFMSDMISDLFIIADVEQEFIKQSIDTLNTFTKTRPQIILRHLPLLSSYMQSLELLPVGQLRKYHGILLVILKMLLNLIPKLNGKASSIEPILKSMMTLFEMMNRRYCPDLICAFSEVTALYVELNTCAAKKFLLMHADIMRYLVNGVDSAKQILHIVSSRTTDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5U6</accession>
    <name>A0A158Q5U6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10348</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5U6"/>
    <dbReference type="WBParaSite" id="DME_0000833101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000833101-mRNA-1"/>
        <property type="gene ID" value="DME_0000833101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000833101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="717" mass="80882" checksum="7238B4D325AFE519" modified="2016-06-08" version="1">MQCDGDKEIFHKWILWKEEADKSVPEQFKTKKLPECHYSGEMMSTRSLAWVGDGKIFDNFPYNMLYQCNSKETRCYFIAEEYGTLAHHMKTRHGLSVDKPELSDLTHSLLSPSHYELPLPQRLTDVQTSTLKRPDEHKIERTSVSTPVKNNQLTILPKVYSIKRSNDLKLSLKASPSETVNIKKSRTNKDRRKGKKRKSLKTAKIQNGETAASKRSEKRVTFALPSDDDDMSLEVLRRQGEKANIAVRNVVPSTSRFLDSGSSIANFHSVTSLGLGAMEKVESESVSSRAESTFDNIILESPSKSHQSVRRIARKLACPSFSSGASMQDSGKISSLEQKPIKSQYSLDIASGNYHNFDNCETGQISNNPDVIMVDSRHEDTNSEILIDKIETNSATSETSNQFGRSFVIKHMNVTRMQKSYRTYKVDLSRAMAGKFTLLKKVALECENNEQFDESVDSIEQQKMDESVFPVELKHNGSSVSVPHNYFPSGGVDEVIYANGGDQQIRHHLSLNERSFQENNFFITRPIKQQIQTDHAALPKLFDNRLAVPDAVISNEQNSTTANIPRILNPIKPISLKKSISSSMNNNYRFSNSVVPRFTADSSDVEGTVSVDYQCYNHPSSARNPVKDNMIVQSDNQKQYVRNSVNIFSCARVAKNSYMNQQSSTKDINCQSNSDAIQYSVHSEPIIFSNETNMNQTSTQLLESSLFDMPNLEPNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5X7</accession>
    <name>A0A158Q5X7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10403</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001215">
        <property type="protein sequence ID" value="VDN60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5X7"/>
    <dbReference type="STRING" id="318479.A0A158Q5X7"/>
    <dbReference type="WBParaSite" id="DME_0000853601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000853601-mRNA-1"/>
        <property type="gene ID" value="DME_0000853601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831900at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000853601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10220" checksum="D86D283805C3E13D" modified="2016-06-08" version="1">MCCNKTLEEMMHQSYQELRNERNWQSKLCICDSHRIATHAEKFFNHSFETVVSGGDFAAKVHYHSSFLCKIEMHGTYMLAYGTPLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q630</accession>
    <name>A0A158Q630_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF4200 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10549</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001224">
        <property type="protein sequence ID" value="VDN60576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q630"/>
    <dbReference type="STRING" id="318479.A0A158Q630"/>
    <dbReference type="WBParaSite" id="DME_0000894101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000894101-mRNA-1"/>
        <property type="gene ID" value="DME_0000894101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6432391at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000894101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52651" checksum="EBC250F9814BF126" modified="2016-06-08" version="1">MEKSIHRLEKKNVLKKYESKMIFADGIKKTLDQLEATFKELKKHTEKEKADVENIEQPSVRNFLKQQGTWNDRFDKEQKDYLDALNKQELAEKEMAGAKKQYEKATHIADIYKKHCDTLHELYDKQDRLLSSIFGNDYASEKENRMENELEEIIEWQQRVSLAKFKWTNARVLLVHACTQMAFGIARWKQLNNIDAMNTRMRYFAAAEARNNFIAAGQNVQSCRIYLGKVQFPYCTKEEMFAMEEALNNAFNDIETDETLNDALSVYETTHKKLASLIQWFDKVITETILKDLDKANKEITKKRKQIRTERLAFMKKKVKEEFGYELKIIHDKDDELDKELLILEKDEAEDQSEIHGKNLSVFTSIKINIDISEGDVKQKLDEYGSTRKEMEKRNTLQREKQEMALQEKLKLRAKTGKKSRKQRKQDVTTGIQSQTEIMIVDEEQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6D0</accession>
    <name>A0A158Q6D0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Developmentally-regulated GTP-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation factor GTPase DRG1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10751</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001243">
        <property type="protein sequence ID" value="VDN60778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6D0"/>
    <dbReference type="STRING" id="318479.A0A158Q6D0"/>
    <dbReference type="WBParaSite" id="DME_0000977901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000977901-mRNA-1"/>
        <property type="gene ID" value="DME_0000977901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002634">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="12">
        <location>
            <begin position="50"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="275"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000977901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39295" checksum="B550B39E488C92BE" modified="2016-06-08" version="1">MARTQKNKATMGHLGMLKARIAKLRRELISPKGGAGGAGEGFDVAKTGDARIGFVGFPSVGKSTLLCNLAGVYSEVADYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCSLILMVLDVMKPLQHKKLLEHELEGFGIRLNKRPPNIVFKRKDKGGLNLTCLVAQSELDVELVKTILSEYRIHNADVTLRCDATSEDLIDVIEGNRIYIPCIYVLNKIDQISIEELDIIYKIPHCVPISAHHKWNFDDLLEKIWEYLNLVRIYTKPKGQLPDYNAPIVLHSESKTVDDLCFKIHKSLQKDFKLAVVWGSSVKHNPQRVGKEHVLNDEDVVQIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PJC7</accession>
    <name>A0A3P7PJC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS86</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PJC7"/>
    <dbReference type="STRING" id="318479.A0A3P7PJC7"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN50113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="327" mass="36702" checksum="B3725DC810D0B90F" modified="2019-02-13" version="1">MFLKSILAKEILSFNLYFLLTYNLKVPRPLTLSWNCEGTRLAAGAEKSVAVVTLDSSYRTKSIFHGYGHNEQVDQVAFHPSNPYLLASASADRTIRIWDIRQTRTHTRLTTKGNIFLKGDSQNLNVAWSPCGTYFVYGDKEDTLNLVDGRFLKTMKAEILKDETNEFAFDQSGKHLFVALGSGKLSIYRMPEVQLFRTIQAHSPQSTCVCVSLSPDGNRFAIGASDAICSVWLTQDLICEYNITRLDYPIRSVSFSADNQIIATASEDHSIDIAWADTGERVHEIRVNAETYTCVWHPNVHLLAYASAPPLDSRDREVTVKLFGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PQI1</accession>
    <name>A0A3P7PQI1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS2666</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PQI1"/>
    <dbReference type="STRING" id="318479.A0A3P7PQI1"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="25"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="708"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDN52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132866" checksum="49503D70527C35A6" modified="2019-02-13" version="1">MLNLDTMEKFGSVPEQISFSAEELKILKKWKDENTFEQSVRLSIGRPCYSFYDGPPFATGLPHYGHLLAGTIKDVVTRWAYQNGHYVERRFGWDTHGLPVEFEVDKLLGIKCPQDVLEMGIDKYNSECRKIVMRYASEWEETVERMGRWIDFKNDYKTLYPWFMESVWWAFSQLFKKGLVYRGVKVMPFSTSCSTPLSNFEAGQNYKDVVDPAVVVGFFLDEDPSIQLAAWTTTPWTLPSNLCIAVHPELNYVVVLDKSSSKKYILMEEVILTTTKKQRISELFKNTDLYEILDRFKGKTLEGKTYHPLFPYFQHLKKKLGAFRILTASFVTVDQGTGVVHQAPYFGEIDFHTCLESGIITKDMKPVCPVDECGRFNEEITDFKGIYVKDADKLICKYLKEHGNLIKHSEVMHSYPFCWRSDTPLLYMAVPSWFIRVEAIASHLLANNEKTYWVPSFVKDKRFANWLKDARDWAVSRNRFWGTPINLWVSDDLEEVVCPESIAELETLSGIKITDLHRESVDGIKIPSKTGRGELCRVSEVFDCWFESGSMPYAQRHYPFENLKEFDDNFPADFIAEGIDQTRGWFYTLLVLSTALFNKPPFKNLVCNGLVLASDGSKMSKRKKNYPDPMEIVSKYGADALRVYLINSPVVRGENLRFREEGVRDVLKDVLLPWYNAYRFFIQNVELLEHDFGTDFLFSDDDSTNIMDRWIISFTNSLISFVRKEMKEYHLYAVVSPLTKFFDTLTNCYIRLNRKRMKSGDENSRSEALTTLGRVLLITVRMMAPFTPFFCEFLWQNLRKIVSSPSDSVHFEMIPHSKHELIDETIERRVSAMRSVVDLVRVLRERNSVPVKYPLKEMIVINRKNQFLEDVESLEEYILSEVNIRKLTISQDKSKYGVHLKAEPNFKQLGARLKSKQKKVVEYLKNDVTDEELTHFLENGSMNVLGHELGSDDLSVSFACSLSSSAGEYFETNSDGQTIVMLDMSEDDSLRDDGLAREIISRIQKLRKTAKLVSSDSATAYCLITPPEHRLNTVLESYCAYISNATGTDLKIGAPEHKCEFNSSSSIKGAQLELCLSVNTHVLSAIFHYSNETRRIGLKLPSGTITYSRLLYELRAVFSLWSKSGISLSFNPPPTISLVPSGIDIESLNNKILYVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PRY6</accession>
    <name>A0A3P7PRY6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PRY6"/>
    <dbReference type="STRING" id="318479.A0A3P7PRY6"/>
    <dbReference type="OrthoDB" id="5918434at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="336" mass="39013" checksum="4406197BF46DE90C" modified="2019-02-13" version="1">MKNDIPFKSPFEILSTVLPSSNGSLKKCPLYTPPFQRINFDDMKEAAIEERKPAWKQLEESIKDSYYKVRKTAERSKEEMQFMDSQLCRRNFRRSESPFEILSARSPSVQSPSFHTSHPLTTGEFVENNIYVAPAVFSTQGIESRHEKKANDIEARLLRTSVLPQSMKTITTKEFRNGPAPAAGSTSEILMDEVDYQAFLPRPYYSRPNRHDPDYFDFDLQHSVDLYRRPEGKYVPRGPQEWEEKILQEMKSKGEAPVSGYMFTKGNTDWRNHGTSYLSAALRTASFWEQRFTAIGREIRDKNPISFESLARNKPVTSRWTEYRDPDFEDLTDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PS26</accession>
    <name>A0A3P7PS26_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PS26"/>
    <dbReference type="STRING" id="318479.A0A3P7PS26"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF48">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="139"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="294" mass="34330" checksum="D339C05A58D858AD" modified="2019-02-13" version="1">MCNVVCRRASSFPVVNNHRITRSNKFEFEETVESLVELSENSEENKDESLITGAIAQITLETVVIKKSKNKSVRFADDCGGTLYIIKQMTEPSDFPPKINPKILRRYRGLPENDENDSKLPATWTPTFTQPASDYVIFREKVTKDNIALENVRLKNEEHRLAGTIKVKNIAFEKRVFIRVTTNEWQSYTDHEAKYMSSSSRLIDTFGFEFEIPSDQEMDNAHIEFCVCFEQYWDSNGRKNYSLKSEERAEEERRGIFKHAGPYGNIENDAYLTQMDNWSRFASWKLYDLDQPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PVR9</accession>
    <name>A0A3P7PVR9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS9003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PVR9"/>
    <dbReference type="STRING" id="318479.A0A3P7PVR9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08317">
        <property type="entry name" value="Death_ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="79"/>
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    <feature type="repeat" description="ANK" evidence="9">
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            <begin position="174"/>
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    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="207"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="240"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="306"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="339"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="372"/>
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    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="594"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="627"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="660"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="11">
        <location>
            <begin position="864"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN59030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1707" mass="188572" checksum="BE9E4C0BEBD7FB69" modified="2019-02-13" version="1">MRSGTDINTSNANGLNALHLASKEGHVDVVRELLKRKAFVDAATKKGNTALHIASLAGQELIVIILVENGANVNVQSLNGFTPLYMAAQENHESVVRYLLAHGANQALATEDGFTPLAVALQQGHDRVVALLLENDTRGKVRLPALHIAAKKDDIKAATLLLQNEHNADVTSKSGFTPLHIAAHYGNENVAQLLLEKGANVNYQARHNISPLHVATKWGRANMVSLLLAHGAIIDCRTRDLLTPLHCAARSGHEQVVDLLLEKGAPINAKTKNGLAPLHMAAQGDHVDSARILLYHRAPVDDITVDYLTPLHVAAHCGHVRVAKLLLDRNADPNARALNGFTPLHIACKKNRIKVVELLLKYHAAIEATTESGLSPLHVAAFMGAINIVIYLLQQGANVDVATVRGETPLHLAARANQTDIVRVLVRNGAKVDATARELQTPLHIASRLGNTDIVVLLLQASASPNAATRDQYTPLHIAAKEGQDEVAAILLDHGAQKTPLTRKGFTPLHLAAKYGNLSVAKLLLERGTPVDIEGKNQVFYFIKLNIAADYKSLKVNCHLLSVTPLHVSAHYNNDKVALLLLENGADVNSESKAGFSPLHLAAQEGHREMCALLIENGAKVGAQAKNGLTPMHLCAQEDRVNVAEELVHENASIDPQTKAGYTPLHVACHFGQLNMVKFLLEHGAPVSATTRASYTPLHQAAQQGHYNVVRYLLEHGASPNVQTSTGQTPLSIAERLGYVSVVEALKTVTETTVITETTTITEERYKPQNPEAMNETMFSDSEDEGEENNLTANAHVRDFSESLTQGLHDSTGVHLIHTAEPVSFLLVLFFFCKNRFSFAEKISLFDFSKYGAARCFFHAYSYFLISFMVDARGGAMRGCRHSGIRIIVPPRKAPQPTRITCRYLRKDKLAHPPPLSEGEALASRILEMAPHGAKFLGPVILEVPHFASLRGREREIVILRSDDGQHWKEHQLEATEDAVQEVLNESFDTEELSQLDDLQTPRITRILTNDFPMYFAVITRVRQEVHCVGPEGGVILSSVVPRVQAIFPDGSLTKTIKVSVQAQPVPQEIVTRLHGNRVAVSPIVTVEPRRRKFHKPITLCIPLPQSNQKGMLTQYSGQPGQEPPTLRLLCSITGGSAPAQWEDITGTTQLTFTGEDVSFTTTVSARFWLMDCQTPRDAARMAQEVYNEAIAVPYMAKFVIFARRTFPTEGQLRVFCMTDDKEDKTLEKQEHFIEIAKSKDVEVLSGRHQFLEFSGNILPVTKSGDQLSIYFLPFQENRLAFLIKTRAGSDDEASTNGLISFMKEPKIRSDSLPPQQPICTLAITLPKFTEPITTANASDRVTSVITKYMNALNEERDPDNLPLTLISRLIGPDWHRLARVLDIPDSDIKKIRQQLVGKEAISVLRIWIHLKKQEASPTALSSALHQIGRDDIVREINQTEQPMELDGVVSSYSSLPSTSTSTEPQKAEYLYTTAKVGEHKFVQDSAVAAPIFAPFEREEIVPYTIKEEEEVPVSEVKTVVRKQRHIHDTENGPIVEERTITTTYEDDVAINEEIVDRIVPLNEEEQEKWDHMVREAQQAMEEVIEEEGPEGVTVKTRTVTTSYITRQSPEEDDLMTKPVITELIEPMEVAEHLNEASPGCNLVTDQKHESMAEGFTTEDGSTIVSKKMTRIVTTTKTSTPGLFIIHKIFFLKSKSRDSIDNNKHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PYP7</accession>
    <name>A0A3P7PYP7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PYP7"/>
    <dbReference type="STRING" id="318479.A0A3P7PYP7"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="12">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2/SF3A3 SAP" evidence="11">
        <location>
            <begin position="193"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="263" mass="30820" checksum="B01B81D312224DB9" modified="2019-02-13" version="1">MNDLRMLLATDIKTVSELSLLPSDAFYVTVNGQIVDWKEIRDGSSFVVHFRLRGGKGGFGSLLRSFRIHRSTNQLMCRDLTGRRLADVKEEERLRNWIAKAEERAEEKRRRRLAKYERLKSGPAKHEMNDPHYIRQREKILDETDDAFDAGMFSHCFFIIFIDMNVFICVQLIYHLYFYRQETSWPVQQRNICNNAVKYDEINLDEYESAEALQKLNLDHLKHALEARGMKCGGSLAERAARLFSVKNLKPEEYPKSVLVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0Y2</accession>
    <name>A0A3P7Q0Y2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0Y2"/>
    <dbReference type="STRING" id="318479.A0A3P7Q0Y2"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF158">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="198" mass="22397" checksum="48D2C7A8AC6DA568" modified="2019-02-13" version="1">MQKFAERKSVACSFKNIQKMGEKIELTKELAIDCEFVRGLAGEREISLLARVSIVNANGKCIMDKFVKPTQKVVNYCTFVSGIRPCDLINADPFDKVQCEVAKIIDGRILVGHALDNDLLVLKLTHPQKLIRDTSDYLPLQFICRNSLGRRPALKTLAKEVLGINIQQGEHNSVIDAKTTMQIYNIYKKQWEASLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QDP9</accession>
    <name>A0A3P7QDP9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000112">
        <property type="protein sequence ID" value="VDN53217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QDP9"/>
    <dbReference type="STRING" id="318479.A0A3P7QDP9"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="11">
        <location>
            <begin position="232"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="389" mass="45341" checksum="789F76FE6017D1E4" modified="2019-02-13" version="1">MFYRNDRPRKNFLVNLVENIKEEFEKNKILQENRKQLDKRLKELNDSEALRDARKKFDLVERETMRNSEVIRAKLKELKDYMSQITTEFQASEAGKKLSKVSEESIKQVRVAVESLEKAAEKIGDTEIYRNVTTVKVVKEEVDSIADVRMYARPVNAFSSRIIEANTETTGVELHKESKWYVSWKEFSEKNVYFNKLLDWKIRYDESENLAIRMMRGLTDRISAILSPESEISEVLTEIGKVDANFDKSDWLRFCEVDVIPNVLEAYIRGDLKVLQDWCHERAFNALATVVKEYGKIGYSMVDSRIIDINKVELVTGKMMEQGPVLIITFQAFMLYVVKNSEGRIVDGDPHHPARIHHVWVMCRDMEEYNPAVAWKLLEVHMQKGSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QJL3</accession>
    <name>A0A3P7QJL3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QJL3"/>
    <dbReference type="STRING" id="318479.A0A3P7QJL3"/>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN56291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="270" mass="30411" checksum="85057DD602244590" modified="2019-02-13" version="1">MLRNWQILAVTHPGYVAFLTYDEVKQKLQKYCNKPGSYVFRLSCTRLGQWAIGYVAPDGKIYQTIPQNKSLIQALVDGSREGFYRFPDGRPINPDLTHALQPTPEGHLQVTPEQYQIYCEMGTTFEMCKICAENNKNVKLEPCGHLLCTPCLQSWQESDGGSTCPFCRCEIKGTEKVIIESFHPTKKRVVAKSKGGFGLMENRLTWPPRTEGGPPKLAPPPLPPRRSSPANSVTQETTHRKDPLDLFEQNISPSKVLFSLSFGFSLFFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SJJ4</accession>
    <name>A0A3P7SJJ4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase beta</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Rough endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SJJ4"/>
    <dbReference type="STRING" id="318479.A0A3P7SJJ4"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="230"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="525" mass="60132" checksum="616532710FEE74F1" modified="2019-02-13" version="1">MEEKSQSWLLRLFNSSLFDIVIAMEYLFNSKETGNRLFDFQASSVDFYLPQLINMYINIREVAEVIHPYIIERFNVEFSLECYWLLNAYGVSSFKKNKLKSQGYRLQQLILNGLRYGTDNFNALSPESHYSNGLNYEERSKSEIGPELEFIKALMNIGHKLKGVGSKDARSQLLINELVMVNLNLPARVWLPLYARSIKHIVLRIPNTASCVLNSKDKVIFFHLSSTMSEPWLEKLQRIRDSSPYGRHPKWKLLPVIIKTGDDLRQELLAYQLLTTLHNIWIEEKVPLYLRPYKIIVCSSNSGMIEPIVNACSLHQIKKNLAVHAMGNSSSEASHPTLLTHFLGNFGVMHGESFLIAQQNFVESCAGYSLACYFLQVKDRHNGNILLDSEGHLIHIDFGYILSISPRNLGFETSPFKLTQELIDVMGGIGSDMFEYYKILLLRGLIAARKHHDRIVNIVDIMIAGSQLPCFRGGANTIKALKNRFHMGYTEQQLQELVEALVEQSRDSITTRLYDNYQYFSNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SL30</accession>
    <name>A0A3P7SL30_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Voltage-gated calcium channel subunit alpha C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SL30"/>
    <dbReference type="STRING" id="318479.A0A3P7SL30"/>
    <dbReference type="OrthoDB" id="5787775at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42866" checksum="B92A693E9C3905A4" modified="2019-02-13" version="1">MIQDYFRRFKKRKELESKGGVTHQTSQAMALQAGLRTLHEIGPELKRAISGNLESDFTVDLEEPQHRRPHSLFNNIMNALSGTSSRNHEVYGEERISRLLPITDSNISANHLSPTHSLHGNNVTSLATHAGVNLNMNSSINIPTSPRVNGGIRQRRLPQIPFTRDQKETGAYISYNHRFILANRSHNHFSTPVDTDEDEEWYEQRDTNNIRKNYQWLQDGMPERGLREPFLLARNQALVMAGVPSNMSDAFEGTYRPAPDGKSVRLPFSSRPLLIPAEENEKRLSERLVGEALDLGRYMDERVVQAARREIAEAYSLEESEMERVAATLTDQRYLEHLGMDRCEVRDYNNYSSSALLRPANSQETHDDDLLLVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SX23</accession>
    <name>A0A3P7SX23_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF170</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 170</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase RNF170</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9469</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001183">
        <property type="protein sequence ID" value="VDN59496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SX23"/>
    <dbReference type="STRING" id="318479.A0A3P7SX23"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="207" mass="23655" checksum="84EA0E22F89C4226" modified="2019-02-13" version="1">MQENEAIEQGEAPRTYGSDRTCPICFLSASFAITTNCGHLFCCKCICGYWRYFFPLNPVQCPVCRTPVTLLIPCPIEGEVESNSEEAGLNDNMLVEYNRRFSGERRPFMDHIRDLPVIIPHLLRTLLSFRGLVLMSQCRIILCLLGLFFYVIIPGDLLPENVFGIFGFLDDILIVFFIFVYISIMFRQLLGAGNLHFGWNINGEHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U107</accession>
    <name>A0A0N4U107_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4618</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U107"/>
    <dbReference type="WBParaSite" id="DME_0000025801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000025801-mRNA-1"/>
        <property type="gene ID" value="DME_0000025801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000025801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="48499" checksum="2FECDDA1F2F7F677" modified="2015-12-09" version="1">MTVSYNLNLSTSKPWAQFRLLLRWRGSIWKLVLTECLIFYFTYTIINIFCTFVLAPHTKERLIEFIKWLNPSNKYSFFIPLEFMLGFFVTAILQRWSTALNNLAFIDRIAVAIAGYIHGTSEKCRIIRRNIIRYMCLCEVLVFRDISLPVRKRFPTIDTIVAAGFMLPHEKEIFDSFETTYPKYWVPLQWANLLVYKARTENLIISDIFCEQIFEEIRSFRANLGEVLKVDWVPLPLAYPQLIYLAVHVHFILSLISKQELDAEWWFPKWIPLITLVQFFFYMAWTKVAMVLINPFGEDDDDFETNFLIDRNIKIGILIVDEGYGVVPEQKRDIFWGNRVDPLYSEESAKTTANQANTLVGSATGLTLPENVSKILMMPLNNNDDDDELMEANKFTKRYSIVQIPRSVISKLLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1A7</accession>
    <name>A0A0N4U1A7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4736</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1A7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1A7"/>
    <dbReference type="WBParaSite" id="DME_0000037601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000037601-mRNA-1"/>
        <property type="gene ID" value="DME_0000037601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000037601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="35847" checksum="46CDCACB0261A329" modified="2015-12-09" version="1">MHNSNGRFVRQNPSPLRKLAEKCGHYRRKTNSISINCSNSKQIYFNFYTNNLFSRPLFIPIIYFLDFVKQNDSKNFFCTECVRLACPMGQAGPTGPPGLDGVPGAPGKMGKPGLDGNEVMLDIMPNFPCTICPSGPPGRRGFQGERGMEGAEGIPGLPGRPGVNGEEGPIGKPGAKGDKGQPGPDGSKGPVGDAVIGGTGSKGPKGPIGARGPKGPIGLPGRPSNTPGVAGKPGKIGPPGPEGKGDKGTKYKIELTAYSHKKEIKMKYQTEKNINENPNSFKLGDYGEHGPWGTPGEAGIPASYCPSDCGISKIFAPYAFGFTINEENDEFTDSTIYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1L5</accession>
    <name>A0A0N4U1L5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4866</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1L5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1L5"/>
    <dbReference type="WBParaSite" id="DME_0000050601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000050601-mRNA-1"/>
        <property type="gene ID" value="DME_0000050601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000050601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53271" checksum="E47F0F7848A137D2" modified="2016-06-08" version="2">MFHLYQVDLAVGDCSRKRKNERSISSLHTFSDSGASERTSTSSSVRSSLITPAPILENNQTLIHSQIVINGFRDTLARTLAIHEDEHVVRTHVQKFGNNILHQPERLVRKSNSMTKSESCKNSSPHPSRGNKSLLTQNVSTDIPQIVTNGNLAEVVDVETLEDLRCEWQGCTQTFSTQKALVDHVTLSHIQASRKYCCLWRGCDREEAFKAQYMLVVHVRRHTGEKPNVCSVSPIYPGCDKSYSRLENLKTHMRTHTGERPYKCEFPNCGKAFSNASDRAKHQNRTHSDTKPYQCVMADCSKSYTDPSSLRKHIKTVHGEDVYEMSKRNKPVRRRRNDVNASASTTNSKPSSNLTNISTVASRRDIEDTEDEAKKTTSDTSHFLCTHIASTIGIPCCNFAWPFDDELIKISILSASCVYKEKIHFIYVNPDSDSRCSCGHYSVLFAFCLNCKKKRLQHNRIQGLWYCDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2B6</accession>
    <name>A0A0N4U2B6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5167</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="protein sequence ID" value="VDN55194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="318479.A0A0N4U2B6"/>
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        <property type="gene ID" value="DME_0000080701"/>
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    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="RING FINGER PROTEIN 130"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:CH211-59O9.10"/>
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    </dbReference>
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        <property type="entry name" value="zf-RING_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN55194.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000080701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39614" checksum="D04AFF6B61866C9D" modified="2015-12-09" version="1">MVKLQQQQSQSLQCGTTTFNKLSFDPATKLSLLPSAKLTNILLENIIGSNDICYQVKHHIPPKIKHSFTTFQQLITTCLNCTKCSSSLANIYRYLHEILKDVKVSLIVVIRGVNHRQINDINEEKKVRFAFIEDDAPLSLDDCQIIDGNEGDAFRYAHAKDRLQRRLFNAAKKALTRIPTRQLRQDDKDLDSDCPVCIDPYRSGDLVRCLPCRHVFHKMCVDPWLLEHRTCPMCKSDILKAFGYHVSLNRRTPVNNQIEESQVVANDRLNVDVHSTGSESIFPFTNHNDLQEPFSFTPSVSSQLVQQVMHSSNASAFSIIPLTVHNVPLSTSRNLQTSIQRGNFLSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2D9</accession>
    <name>A0A0N4U2D9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5197</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DME_0000083701"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="VDN55224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000083701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11559" checksum="A51D31673A7930A8" modified="2015-12-09" version="1">MSRVPIVFCNIWFLPKRFSGIGFGRVDTLKWRCCPVIKFDEIIVFGIALDPFLRPAPLIGATSLCSPFTTFDLVRFIDCYGGLLSVPVKCYVLSLYQCVSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U433</accession>
    <name>A0A0N4U433_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5881</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DME_0000152101"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000152101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12831" checksum="3B68A82DF4010E39" modified="2015-12-09" version="1">MDDEEYDTDIDELGNEVEQEEDDDNVSFISAVSSQPNNNIHMMDDTLPQPECQYSTQKFLDTFDRGLAKRQSKGKYQVSLIDYFLFFFYFFQVMQLIHNSCEELFRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U498</accession>
    <name>A0A0N4U498_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DME_0000159501"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000159501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36674" checksum="51159529BE4D5C09" modified="2015-12-09" version="1">MIQWKNGILSEFFSVLTPQDCVARLSVKKQMSKDCMISSIWKWKNDSYRNLAICTKLFQQEAEQNGNILEMQLLQQQIDALDGRAAELERRRTQSTRGISWINQRNRQAMKDAVFSGQLHIEASSEYDPFTRKNARTKPVFGKDKRSDDTASGGVIEVNTNYKNASFFSKTIEKTGNIGSKRTVDDLFSAHDFEVDVDIVLPPTVASLGTHSLNSVDTLSHKSPASSTDSVNRPRPLTLEEYRLRKAQMLAFGTYINTVLQSWLDSSVLKSYVMRPFPIYSRNGLKDYTILCKIHRWIVQPHRWIRAVTHPSWAVASLHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4E1</accession>
    <name>A0A0N4U4E1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6005</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4E1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4E1"/>
    <dbReference type="WBParaSite" id="DME_0000164501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000164501-mRNA-1"/>
        <property type="gene ID" value="DME_0000164501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF96">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000164501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19264" checksum="D49F9A0421FF0B69" modified="2015-12-09" version="1">MEMVNETLNEDDDLMMTDESDIAMLARFYYCFMLACILIGLTGNSMVWVLIRSNRFLRKLPSNTYLLTLSAMSSLFLISLFTFWLEEVSNLEELASRAVNSRLIKLIISVRNIAMVFQEHLLVYRSALFCKSLTFVAHFCDFSSVWLIVLVGFERLVLLYRSSFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4L7</accession>
    <name>A0A0N4U4L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maturase K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6095</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4L7"/>
    <dbReference type="STRING" id="318479.A0A0N4U4L7"/>
    <dbReference type="WBParaSite" id="DME_0000173501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000173501-mRNA-1"/>
        <property type="gene ID" value="DME_0000173501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000173501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="20262" checksum="C1A2682E291EFF7C" modified="2015-12-09" version="1">IFTKKFVSLCWSFFFYSSKLKLQTNLFIHILWLFSDKSIFIVLIGFYRLIFHLNLKKVLNMRDDHRFLFFWFENFYYRNRFCDFVLFSIFTYRDMTVEQKFEYFKQLVDIIDPFRKRVHIILPLLVSSPLSVKLNVLKECVTVGYDDISSLNIYLLEHFVLKPIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4N7</accession>
    <name>A0A0N4U4N7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6116</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4N7"/>
    <dbReference type="STRING" id="318479.A0A0N4U4N7"/>
    <dbReference type="WBParaSite" id="DME_0000175601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000175601-mRNA-1"/>
        <property type="gene ID" value="DME_0000175601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000994">
        <property type="entry name" value="Hypoxia Inhibited Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF583">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="536"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000175601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="808" mass="91855" checksum="B3C69046F4F6A129" modified="2015-12-09" version="1">MSVNVYYIYFILNIILLIISINGKSIGTELCDEACIAHRCKLRCIANCVTIKQQRDNRNNNCLQLCDGLSKSSIIPEVPSEISAIYDSTYAVNLTWKAQAEAIYLLQFSLNSSFDKDNEIIADSNSLLNYTRDFSDFCHHIMVRIAAITTNGISNFSAIYHIAPPQPHVDDILTVHLLEYVNQTYNLSDYTFNGSVRLVFEYTGADWPLGDDDLFVEPLFHMTGCKEIDLAIAMPSPIFKKGSSPRTTEAMLSADMMYKKCEFLYYAESIQSKKCGTITRSSDANMQTMRKLKIDCTTVLHSPCDQPKRHQPPLCGQVEAFSYTVLNKNINADDPSTIITINITFRSIINNQKIPLYFIAFYGDAQNFEREADVELLGVDMYDVLGNTTNCPKFLYNGSCAEKINPINGSFIVSDLQMDKLYGITICAVMDPKNLTFPTFRNTSLNMKSKAHKIFIRSSDYRKSKTPMIISTVAVIIAAIFLLLITIFANIHRKQQEKMKLNKFKLEQLKMENEQRYTNLPKRQDIWELERRNLIIYDEKKLGSGAFGSVYMGKLIGIAKAYKNAQSTLGVNLMRAENCDVAVKMLPEYADQTSKTEFLNEIALMKSLGYHERLVNMLACITETEPYCLIVEYCSDGDLLHFLRSRCKYMFKLKEMNIDYESGDDNENVDRDMIITLKQLLMFAVQISYGLEYLSQKGFVHRDVAARNVLVHDKINAKIGDFGLCRYIYAKTANYKGKGGRLPVKWMSPEAIKFYEFTTKSDVWSFGILMFEIITLGGAPYPGIQPDDMVEYLNAGGRMEQPDNCPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4V0</accession>
    <name>A0A0N4U4V0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6196</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4V0"/>
    <dbReference type="STRING" id="318479.A0A0N4U4V0"/>
    <dbReference type="WBParaSite" id="DME_0000183601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000183601-mRNA-1"/>
        <property type="gene ID" value="DME_0000183601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="86"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="14">
        <location>
            <begin position="298"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000183601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45801" checksum="6B4E9C4FBBDD8D7A" modified="2015-12-09" version="1">KVSRLNLKTDEFWNISPAIISLLERKLFQQPKNPITLLKDFIVECMQNVIRDEGNSKFLIVSENFDSLLIAKDHVCRSRSDNYYINKDFCLRSHTSAHQYEFLKQGLERFLIIGDVYRRDQIDRTHFPSFHQIEGVCLYSSEQIFNGSNVNFLNHFLFFFLKKTSEKQEHHKIITAKAVTEKLKSALEVLCRHIFGEAIEMRWLDAYFPFTHPSFELEIFYEGEWLEVLGCGVMEQKLLESSNVFNKVGWAFGIGVERLAMVLYDIKDIRLFWTNDSGFLSQFVDKSPSDRFKVRPISVHPQLINDLSFWLPDTVMASQITSDTYDIIRSLGGSLVEQVNLIDSFTNKLGRLSHTYRIVYRSNERALTKNEANIVHKAIERKLVDIYNVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5Z4</accession>
    <name>A0A0N4U5Z4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6666</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5Z4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5Z4"/>
    <dbReference type="WBParaSite" id="DME_0000230601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000230601-mRNA-1"/>
        <property type="gene ID" value="DME_0000230601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000230601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38611" checksum="28DE926AA612B48C" modified="2015-12-09" version="1">MSILLTGAAGFIGSHVAVELINAGYNIVCVDNFINSVQDEMGDAVSLKRAEKIVGQEICFIFADCTNERDLEKVFQKHTITGVVHLAGLKAVKESVEFPLDYYNNNLLATLSLLKMCKKYNVKNFVFSSSATVYGTPVKLPITEEHPTGVGITNPYGQTKYIIEKILIDLSNAEKDWNIVLLRYFNPTGAHQTGLIGEDPKGIPNNLMPYISQVAIGKLERLYIYGDNFETPDGTGIRDYIHVVDLARGHVSAFDRIKKLGSIGCEVYNLGTGKGYSVKEMVAAFEKASNRKVPSEITTPRPGDIGCVYCDPSLAKEKMNWECEFGLEEMCRDLWNWQLKNPNGFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U677</accession>
    <name>A0A0N4U677_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disintegrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6766</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U677"/>
    <dbReference type="STRING" id="318479.A0A0N4U677"/>
    <dbReference type="WBParaSite" id="DME_0000240601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000240601-mRNA-1"/>
        <property type="gene ID" value="DME_0000240601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912366at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000240601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26584" checksum="C57722E474A0C8D1" modified="2015-12-09" version="1">MKAYLQKISKFIFSCVSVCSLRSMKQCECDTEEDNYCYLCCGNSYSRCLPAHHYNILRDNGERWERDACARCRQNGVELEGLACDDTDPARLCIQGKCSNSVCHDKPQGAYCDRKMEKICVSDVCENPCTRFGSHLMVCDCPLIDPDTGFASDDRCQLCCYDFNIKPSSRRCQNAYRKYNIATAQNRPIWRVGLDCIGGKKCNRFGICRALSIKPSLWLIFTAFSLVLCKYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6K5</accession>
    <name>A0A0N4U6K5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6921</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6K5"/>
    <dbReference type="WBParaSite" id="DME_0000256101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000256101-mRNA-1"/>
        <property type="gene ID" value="DME_0000256101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872694at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000256101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39438" checksum="0C48C611198FF6D1" modified="2015-12-09" version="1">MEKTKIPPVIQRSIRPYHRGNGPLRGGGMTAMYGVSPNMKNYKRKLDNRLGYCIFACQITIATILVVYGLIHQYTHDELVNYIITTKEIIINSMPTIEPTQEQKEPMQLIEISSNFTDTSFSANEQSLVEPESCLGAIDVDTEKCLTVDELQEDYDMLHGSNITLWNLATLNIIVALFLITVTCVFANGIVKGTAVKMFYRVTLFMALFFMLIQLIYLINPLFTSAFQYSPLVDKLLIKKLPRDRNAMLEIESHFACQFDTIDKLVEMGLEAIYSVVLLIAIDLIPFSFVLFTYAWDACLKESHLINNARRRIELNNQRRSILGSTLSLDRRKPVTKSKWHSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Z0</accession>
    <name>A0A0N4U6Z0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7085</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Z0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Z0"/>
    <dbReference type="WBParaSite" id="DME_0000272501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000272501-mRNA-1"/>
        <property type="gene ID" value="DME_0000272501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF84">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="3"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000272501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="52329" checksum="86B0F7F80FC69157" modified="2015-12-09" version="1">MDINEYFLIVLYCLLALCGFFGNIWVINHQYLTYLYILILSIVDFISILSLPLIIIDILYNQWPFNIYLCKFLFFCEGTNKTLSPLILTLLSIDRYIIICLPNNYYRQNEYFLLFLLTFVVISLFFIIPIIYKAEITVMFDNYFKEHTKCVLQISKFYDFLHISICYILPLLVIVIVYLNILKKLYKHIKSSTIGNKSNISLNRVIKSSVMIVLFYFICWTPYWILRIFAVFFGSEIVSIYFEMIKLIFYFNILIFFYVEIIISEPLEGTKSSSSFVNIDNNSSYNNILLVNNNNNSSSLSLLSSLLLSPTAAARISLVNSSSLAESIIINNASLINNFNLTTTTTTMATTTTTPSTSHIMLMYIVHSLPYAQSAFNWVFYAFLNKNLRNSFKKNNNFGLKIIQNKRKNNYWKNDIKIDQNYRRYSCYKNGKKFILANKYSCFFNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U744</accession>
    <name>A0A0N4U744_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS18</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U744"/>
    <dbReference type="STRING" id="318479.A0A0N4U744"/>
    <dbReference type="WBParaSite" id="DME_0000278901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000278901-mRNA-1"/>
        <property type="gene ID" value="DME_0000278901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000278901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11689" checksum="95D434DE44F425F4" modified="2015-12-09" version="1">MPVEIETLKAGDEATFPKKGQKVICHYVLTLQNGKEIDSSRARGKPFEFNIGQGQVIKGWDEGVAKMSVGQRAKLTISPDMGYGSRGVPGTIPPNSTLIFDVELLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7E5</accession>
    <name>A0A0N4U7E5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deoxyribonuclease TATDN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS134</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Exhibits 3'-exonuclease activities and apurinic/apyrimidinic (AP) endonuclease (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7E5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7E5"/>
    <dbReference type="WBParaSite" id="DME_0000290501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000290501-mRNA-1"/>
        <property type="gene ID" value="DME_0000290501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46317">
        <property type="entry name" value="HYDROLASE OF PHP SUPERFAMILY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46317:SF1">
        <property type="entry name" value="HYDROLASE, TATD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000290501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30311" checksum="F370723D4EE4FC6B" modified="2015-12-09" version="1">MIDCHCHLADNQFKSDIEGVIERAKQSNVLATLVCSEYRQQFSKVFELAEKFPGFCFPCLGVHPIQKIKEDDVSVRLDDFESVAEIIDQNHAKIAAIGEVRYNVGLDFSPRYLKSADAKEQQILVFKSQMDMALKYDLPLNVHSRSAGRPVIELLQKYGARRVLLHAFDGNEKNAQPAIDAGYYFSIPPSFSNSEKKIKLIERIPLGQLCLESDSPVLGPKKGERNEPKNIFISAEFIANIKKIPLEDVIKITTENAKKLFPFLKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Z0</accession>
    <name>A0A0N4U7Z0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Z0"/>
    <dbReference type="WBParaSite" id="DME_0000313101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000313101-mRNA-1"/>
        <property type="gene ID" value="DME_0000313101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000313101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10177" checksum="7489A7F61EDC617A" modified="2015-12-09" version="1">MCKFLPELRAHPCRSAFRKRFYARLSYEEENEDVAVDITVNKMSTTIARSQLESSNSDTAELPSSISKCNRQRTWYNPSVRRKRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U852</accession>
    <name>A0A0N4U852_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Autophagy-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7359</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U852"/>
    <dbReference type="STRING" id="318479.A0A0N4U852"/>
    <dbReference type="WBParaSite" id="DME_0000320001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000320001-mRNA-1"/>
        <property type="gene ID" value="DME_0000320001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000149">
        <property type="entry name" value="microtubule-associated proteins 1A/1B light chain 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000320001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14775" checksum="EAC2685ADAB61012" modified="2015-12-09" version="1">MRSSGGHIPSFKDRVPFDVRLRDALNVRAQHLDKVPIVIERYEGENSLPVLPRCKYLVPSHITIAELMQIVRKRMDLHWSQSFFMFVRNKSLISNSMTVGELYHKEVDDDGFLYISYATQLAFGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8H0</accession>
    <name>A0A0N4U8H0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF4457 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS207</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8H0"/>
    <dbReference type="STRING" id="318479.A0A0N4U8H0"/>
    <dbReference type="WBParaSite" id="DME_0000334101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000334101-mRNA-1"/>
        <property type="gene ID" value="DME_0000334101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304622at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027859">
        <property type="entry name" value="KATNIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14652">
        <property type="entry name" value="DUF4457"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="263"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000334101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66332" checksum="D58ADA238352EC40" modified="2015-12-09" version="1">MENNFAIPELPSGHTLYFVFLTSWGDPNFVGINTIELFNANGERPDFQSIETNATETIGDLENILYAGHFLCTDPLRMWSARYDILDKDEVRIKIQLKTIERLAMIRIWNYSECRVHSLRGVRHLRIDFDNQTIFRGEISCAYTNESGEYPLGDTILFTTDEEILENIANNDICFAGEEFIMDNLNLDKFGLLSISSKNPDEMNSSENSFMLSRRPTTGDRQEEEKSTSNENLDYIDNSGKITLLPDKERASEIAKTNVFQMELYENWGAPDCIGLTGLQFLGSRTTVLDIKHCLATASTGLQTAQKLLNGRNLTGDRDDMWLVPHTPDLPPPCITITFPEPLQIIGVSIWNYNASPEMSYAGVRLAKIYLNGKALDSLILLRKAPGEYFGAISRVRSRFLNDKRYVLFDFVQDIFFDNCDCLFRPLPRPNTSSLSGFIYQLQLYSTWGDEFYIGLNGIEFYSHLDSLIPLRAHNLAAFPESVNVLPGVNADPRTSENLINGENDTDSMSNIWLTPMLPNHCARIFVVFDIPTFVSQIVIYNYRKTPERGVRHLSVSVDDLIVFSGEVPTSTTEKTGILRVSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8I5</accession>
    <name>A0A0N4U8I5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS226</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8I5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8I5"/>
    <dbReference type="WBParaSite" id="DME_0000336001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000336001-mRNA-1"/>
        <property type="gene ID" value="DME_0000336001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000336001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20785" checksum="D85B4A899858A788" modified="2015-12-09" version="1">MSYALSKWRLNERHRLIAEGKISSVKYEWEKAKWAMGERFGKYGIASNVDIRQLWPSVEVSLLYNEVEAILRNIYLKTELRLEFQNYSNHLDKYKASLMKMEDVKSEEEKKMENRIREIQEYFGYWIDPKDPQFQVMLEKKKTEEKKAEKLAKRQALQKKKYAEIVMQTDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8L6</accession>
    <name>A0A0N4U8L6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DDA1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS263</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8L6"/>
    <dbReference type="WBParaSite" id="DME_0000339701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000339701-mRNA-1"/>
        <property type="gene ID" value="DME_0000339701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8598182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018276">
        <property type="entry name" value="DDA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10172">
        <property type="entry name" value="DDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DET1- and DDB1-associated protein 1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000339701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11278" checksum="25224C2B57F89DCD" modified="2015-12-09" version="1">MASETNSCSEFLKDLPSNDEGNFSKCCRFWKKSNDVYIAHIVSHNSDEKRITMDKRPLILRYLEKKWQHSEESGKNLKRTSDSSVERPGNAKIRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8X3</accession>
    <name>A0A0N4U8X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7516</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8X3"/>
    <dbReference type="WBParaSite" id="DME_0000351101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000351101-mRNA-1"/>
        <property type="gene ID" value="DME_0000351101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000351101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8144" checksum="46D5705282C43848" modified="2015-12-09" version="1">MAKSAQITLSDRIFNTNGNRAEVDTLSEIYPMSFLEAAWQTHGMRGWSKADMFNYFPLYFPGSSHSHWLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U914</accession>
    <name>A0A0N4U914_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">4-nitrophenylphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7560</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U914"/>
    <dbReference type="STRING" id="318479.A0A0N4U914"/>
    <dbReference type="WBParaSite" id="DME_0000355501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000355501-mRNA-1"/>
        <property type="gene ID" value="DME_0000355501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000355501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32930" checksum="9499B0FDF58A5FE9" modified="2016-06-08" version="2">MSLKQVKTNFNANFVDNFDFFLFDADGVLWLGDKALPGAVDFLELLIKKGKNIFIMSNNSTKTIKENINKLHKLGFLMVLEDHVISPAKVLAHILSKTPSDLPVYLIGSEGLQKELLNKGIKSFGVGPDMVEKYTDDNFIYDIDTSQPVRAVVVSYDIHINYVKIMKAVNFIHHHKVDFIATNEDSTLPGPIKAGVNVKAVEKASGKQPIVIGKPYIPMFQYISEKYSVDANRSVMFGDRCDTDIKFGRNAGTKTVLVGTGVHNLEDVREILSQNLLDQVPDYFCASLDSLSKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9A9</accession>
    <name>A0A0N4U9A9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7665</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9A9"/>
    <dbReference type="WBParaSite" id="DME_0000366001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000366001-mRNA-1"/>
        <property type="gene ID" value="DME_0000366001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000366001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20090" checksum="0C4F7E152F907209" modified="2015-12-09" version="1">MGDLNTISEGVISNSNTHLPPTSPKPDGSTTNRFLIVNNATDALQQSTFTILPNHLACPYDFYLGSGANLNRPSIEQYLPLPYQNLIQPNNFRPVLPAADNTSQNRDLSTLDSRNTIDSSHIIKQPTTPSNAVSTAAISQAPLLSDSPIYCSNNSNAINNFVAGSSISGNGARINPLTVSSLLRFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9N7</accession>
    <name>A0A0N4U9N7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7817</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9N7"/>
    <dbReference type="STRING" id="318479.A0A0N4U9N7"/>
    <dbReference type="WBParaSite" id="DME_0000381201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000381201-mRNA-1"/>
        <property type="gene ID" value="DME_0000381201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5814089at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000381201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4663" checksum="C7AE538CEA24178D" modified="2015-12-09" version="1">MNTLAVLNENCCAICGIMFGLTIDLVQHIRTNHRSSRFNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAJ1</accession>
    <name>A0A0N4UAJ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="32">CAD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">DME_LOCUS8056</name>
    </gene>
    <organism evidence="30 32">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29 31" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAJ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UAJ1"/>
    <dbReference type="WBParaSite" id="DME_0000417301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000417301-mRNA-1"/>
        <property type="gene ID" value="DME_0000417301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
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            <dbReference type="ARBA" id="ARBA00049534"/>
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    <evidence type="ECO:0000259" key="28">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN58083.1"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="WBParaSite" id="DME_0000417301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2168" mass="242382" checksum="D645160910F98124" modified="2015-12-09" version="1">MVGYIESLTDPSYANQLLVLTYPLIGNYGAPDPLELDEFGLPKYYESKKVWLSALIVNRLCPEDEHSHWQAFSSLNQYLEYSNVPCLSGIDTRQLTKIIREKGTMKAKIIVDGDKYEDYEFKDINKENLVAQVSCKEVQHFNNYCGPKVLVLDCGLKNNQIRCLAKRGVHIKVVPWIHPFDAENDYDGILLSNGPGDPAQYSSISAKLNKILKSKHVHPIFGICLGHQILARSIGAKTKKLKYGNRGHNQPCVHVDTGRCFATSQNHGYAVDETEELPDGWIPLFINENDGTNEGIVHKSLPFFSVQFHPEHKAGPFDLEVLFDVFVDCITQWKQGIRSSIRDLISAKFRYETIYKIPEQRKVLILGSGGLSIGQAGEFDYSGAQALKAMREQSIRTVLINPNVATVQTSKGFADRTYFLPVTKEYVTDVIKKERPTGILCTFGGQTALNCAIDLFNDGVFEQYNVCVLGTPIEAIMKTEDRELFSTEMVKINEKIAPSKAAKSMDEAVSAASELGYPVLIRSAYALGGLGSGFADNVKDLKNIVQKALSYSNQVLIDKSLKGWKEVEYEVIRDAYDNCITVCNMENIDPLGIHTGESFVVAPSQTLTNDEYQCLRSNAIKVIRHLGIIGECNIQYAVNPETFEYFIIEVNARLSRSSALASKATGYPLAYVAARLALGEYLPKIRNSVTQTTTACFEPSLDYCVVKIPRWDLNKFARVNNEIGSCMKSIGEVMGIGRSFEEAFQKALRMVSERIDGFSPDVFPKQPSDSDFERPTDKRIYAIARGLYQGNYGVDRIHELTGIDRWFLYRMQNITNTYSKLKQYNIDNLPISHLFNAKQLGFSDRQIARIIDSEELIVRKKRKEFGIEPFVKQIDTVAAEWPAVTNYLFMTYNGAENDLTFNVKKGVIVLGSGVYRIGSSVEFDSCCVGCINELKSLGYRAITINCNPETISTDYDVCDRLYFEEISFETVLDIYEKERPKGVVLSFGGQTPNNIAVSLLRANVNIFGTSPNDIDSAENRFKFSRLLDSLKISQPQWKETDNQALVEEFCENVGYPCLIRPSYVLSGAAMNVAHNREDLRTFLRYATIISKDHPVVVSKFISEAKEIDVDAVAYGGKVIGMAISEHVENAGIHSGDACLVTPPQDMNQITLHRIEKIVRKIAKALNVIGPFNMQLIAKNNELRVIECNLRASRSFPFVSKTLDYNFVALATRCVMAIDNNRIHQTLMSTDIEFNRERVGVKVPQFSFSRLAGADAMLGVEMTSTGEVACFGRNRYEAYLKGLLSTGFTFPKKTIFLSIGGYHAKAEMLQSVRELLAMGFELLASKGTADYFLSNKIPTKTVEWPTEDESAETDEKTSAESLNLAHLIAKKNVHLLINLPIRGSGAYRVSNVRTLGYRTRRMAIDNGIPLITDIKCAKLFIEALRIIGAHPPVNSLIDSISSCSLLRLPGFIDIHAHLREPGGEYKETWQSGTEAAVAGGITMLLAMPNTNPPIIDTNTLKVVDMIASKSSIVDYGLYVGGTADNSEEVKCISANTAGLKLYLNDTFTTLKMDNISDWIKHFSQFPKDRVIVCHAEGRTLAAVLSIAQLTGRAVHIAHVSTAEEIWIIRSAKEKGWQVTCEVTPHHLFLTKDSNLGEGWEEVRPSLANLNDVAALWENIDYIDCFASDHAPHSRDEKVTKKLPGFPSIEYMVPLFLNAVNNGKLTIKQLIDRLHDNPKRIFNLPSQSNTYIEVDMNEKWTIPQEGGSSKAQWTPYAGMSIKGRIRIVVIRGEALFVDGRTVIAPGYGKNIRAADYYEKVETFPNAYKDSNKISPEKYTLVSDVADSSFDRKESFDLSIQMQESLEDEHFKNQSIITVDGLTKSMVNKIFDLATQYRIDTERHNCISDVLKGYVMASMFYEASTRTSSSFSAAMQRLGGMVISMDKETSSVQKGETLEDSVLIMSGYADVIVLRHPEAGAAARASQVTQKPVINAGDGTGQHPTQALLDLFTIRDELGTINNTTIAMVGDLLHGRTVHSLAQLLCLYTGITLHYVIPSEKLAMPQNIVDYVARHGFEQKIFTDLAEGIRGVDVVYMTRIQKERFVSLEEYEKVKNNFVLTQKLLNQVSHLQKLTRKGRERQLPIVMHPLPRVNEICTEVDSDERAVYFHQAKNGMYVRMAVLTLVLDNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAR6</accession>
    <name>A0A0N4UAR6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sigma non-opioid intracellular receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sigma 1-type opioid receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8142</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAR6"/>
    <dbReference type="STRING" id="318479.A0A0N4UAR6"/>
    <dbReference type="WBParaSite" id="DME_0000425901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000425901-mRNA-1"/>
        <property type="gene ID" value="DME_0000425901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000425901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26096" checksum="F23C473891416AF8" modified="2015-12-09" version="1">MAFFFTRIVRYVIFAVILFYAVQYFLRWKSYVISPKIFRTAATASLGANGISSVNMLRNELRRSYGQHIIESGWEAAYGGGLDLRINFLYMAPTEYIAVLHAPYRTSGFSGWHWSNSTCTVLNGEVVRIAYSAYVRNKETFKTGNNFRHGEFDRYTYEFSNESYLACYGRGAIQISSLWLGSGAIARGDPVSFAKILFMYMHRSMHEIGFSISKTAQHYKSKVMNTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBA7</accession>
    <name>A0A0N4UBA7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8359</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBA7"/>
    <dbReference type="WBParaSite" id="DME_0000447601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000447601-mRNA-1"/>
        <property type="gene ID" value="DME_0000447601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039176" evidence="2">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000447601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24197" checksum="039DE4F9F314689F" modified="2015-12-09" version="1">MLPLVFFFISLIHIVNSGGVQIVTCAVTVGAVQRPSVHAQRCTNRDDRVNYLVSDLCENPTLRNLALRECSSHCAFCCKTKQFDCPNAAGAEGACQRLYNEGSLCSDQRLNDIALRRCPHTCGLCDRPGALGACPDQDEYCAIRLLGDPTCSTDFMKKLCKKTCNLRDCLPENNSTIQSKTCFDSDSRCRENAKYCFIGEYGKVMSRVCRLTCGYCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC19</accession>
    <name>A0A0N4UC19_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS8669</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC19"/>
    <dbReference type="STRING" id="318479.A0A0N4UC19"/>
    <dbReference type="WBParaSite" id="DME_0000478601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000478601-mRNA-1"/>
        <property type="gene ID" value="DME_0000478601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="371"/>
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            <begin position="453"/>
            <end position="737"/>
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        <location>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="108" mass="12518" checksum="0BD64B38A802B3EF" modified="2015-12-09" version="1">MATRLREDRDSANCLRKAKKVSVPIVPDIINMDLGRTVKFMDEQKAELSHKYPYFRPNILNLPSTSSTKQPVRRYISHKADPLLMNYCIYSGRYAFPLHRLLVHIISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDS4</accession>
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        </recommendedName>
    </protein>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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            <taxon>Dracunculus</taxon>
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    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
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        <property type="gene ID" value="DME_0000549901"/>
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    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1353"/>
            <end position="1369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000549901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1369" mass="156089" checksum="C42D88524E565007" modified="2015-12-09" version="1">MGNITSAITPDQILPVETFINDLPNMRFVKSLGNTRFMKVAKADFLDGSVIPVVLKFFIPHEEDFLVGRYVDQVYLVRDLLYTAYNCCPFKNVFVTQRCVILSRQYYKETLYNRLSTRPFLLDIEKKWITFQLLKAVAQCEAADVCHGDLKSQNVVISSSNWAQITDFATFKPAFVASDDPSYFTFFFDTSRRRTCYLAPERFYPSHQIKLYTDAPRQFLDISKGLTHAMDIFSLGCVLVELNSTVEEYYPFSYGELVKYKEMNDQEADIFVQNILEKVPHALRRMIGLMLNRIPSKRLTATKLLQKFGPEIFPPLFENLLYDYIYAFRPKFSYSNDSVEESNQNLILMDSDDAIAKLARDMDMIMEMLCKANNGKSDEQLSCVALFITLVASNLRALKSVASKSRFATVADPSVIADRILPYLVIFLSFIFACDFSFVSCGFTVHMALNSLSYGDLFAVNYIQVNMFYDSSLQVRSEAIYKITAILSSLEKIPIRETRLFIDYLFPHLKIVSTDPSNLVQMALAENLGILSETSVRFLYQSSKNLTIDLLGNSTVGEAEEKADWENELARQELRALHEAVNEIFINLCGSDNCVKHCLVASKSFPMLCQFFNRQRSTDVLLSHMITFLNDKVDWRLRAAFFECCPITAKFVGRQSTFILRSLLQQGIHDFEEFVQLRAFWCICTLCKDQLLDKAAIYELLDDVVPFLSHPNEWLRLAVVNILVALDESLNVADVHCKLMPLIKSHLNENLIKLNNKFILIATLRPPISRAIWAFVVNESPLIPLLDYLAEKQMFIALEGGPNSIIATNRSINPSSYELELCLKRLEILGLNNEFEEKLVKFNNVLRKMHSFRVSMIDGRQICKHNSIDLNLLPDVMPRKFDLTSQSHTHEAQKYEEAVDWSNLFGEEPPEVMISDICVAGVSDSFFASKFQEYDMNTSSSWDLTVRSSSCRISLLKLFMYMRQCYLKKTLLHPKSNRLVHERVEMNTSIIARTQQVGTQFLGQIYAHKPVLRKIALNNRESHFVSAGSDGFVKVWSVGRILSKRTGMMIPEGTFSYGREINSVKFIGYDDRLAIATGDSRICIVDTKHLGLITTINFLETDHGAPIELIGANNLLFVRTFHGSIFCFDCRIPQTRKFGIKPSPIWHHKVKDAYGLITSFCTDPSNLYWMCMTSTNRNLILWDLRFGLEVNNWPHPCKKCRMMRCWPALNMGNTSGPCNEVWTSASCSGELSRWSLETGQRSHDRYTITSLVTCPSSGRIFVGDCFGALRSFNLRSAKECFYLSGPLRQTQDIISASASHQNDIRYNVTVVDTIDVIHENSSDCNVKSLFGRSNKMQPEISHTCAIEGLLRTGDLLISASRDGIINIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UE40</accession>
    <name>A0A0N4UE40_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS666</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000006">
        <property type="protein sequence ID" value="VDN50693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UE40"/>
    <dbReference type="WBParaSite" id="DME_0000562101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000562101-mRNA-1"/>
        <property type="gene ID" value="DME_0000562101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000562101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7979" checksum="0FA3D4D051451865" modified="2015-12-09" version="1">MRFRFFGYSLPLLIDRTAQASLMPIKLRPLAIMSVTLMPMLMLITLKPLTATLQSPVAVPITLRHFALFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEF8</accession>
    <name>A0A0N4UEF8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9356</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Rhabdomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001180">
        <property type="protein sequence ID" value="VDN59383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEF8"/>
    <dbReference type="STRING" id="318479.A0A0N4UEF8"/>
    <dbReference type="WBParaSite" id="DME_0000576301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000576301-mRNA-1"/>
        <property type="gene ID" value="DME_0000576301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235974at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17108">
        <property type="entry name" value="FERM_F1_EPB41L5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000024">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1-like 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF25">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="9"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000576301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="49388" checksum="D470042B9874CCB6" modified="2015-12-09" version="1">MEIDQKRQCHCKIILLDGTNMNIVANKNGLGSEVYDQVFYTLDIDEKDYFGLQFMDHYHVQHWLDPMKKLNKQLSIGPPYTFRFRVKFYSNEPNNLREELTRYQFFLQLKQDIQSGRLECPKDIAIELAALALQSEFGDYNPIEHTPSFVSEFRFHPEQDEQMEIAILEKFIACRGQSPATAELNYLNKARWIELYGVDMHTVEGKDGNLYKLGLTPTGTLVFDGSQKIGLFLWEKIQKLDFKNKKLTLIVEEDADQSGQIQLHTFVFNLSSHKACKHLWKCAIEYHTFFRLRYQNSKNRKASHFFRLGSTFRYRGRTEYENVHKDGGRLSRRQSTFERRPSQRYGPRQSLINRRIQLRDEIKQQVRIIPPLLKKFSFHLNSMNLGKWQPSESTNNLTVLERDSNGSLVNLLKEQISNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEI2</accession>
    <name>A0A0N4UEI2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphatidylinositol glycan, class U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS783</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000008">
        <property type="protein sequence ID" value="VDN50810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEI2"/>
    <dbReference type="STRING" id="318479.A0A0N4UEI2"/>
    <dbReference type="WBParaSite" id="DME_0000578901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000578901-mRNA-1"/>
        <property type="gene ID" value="DME_0000578901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000578901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45488" checksum="2438B99D50ADD6C7" modified="2015-12-09" version="1">MKYAETIFKYAENIMVVKFLCERVPLWFLSLLLRVFAKIFFEEFLNKQPEFVVPHNSFRRLIDGIHMRKHGLSPYDGDMLHCQPVLLDLFEPVIDHPNVVLGLFIILDTLTAEVLNFIAITHLRANGDSKSEEEKLRISSFIMKFYLLNPVAIGSCAISSLSVLNNFLVSVFIMSFVKGWILNCSILLSLLVHFSLYQFIYIVALFVRFPIAKKILLFLATFIISFFGMVIINYCSDGGFDYINSTFMFQLEVRDLSPNLGIFCYCKNRICRSNSFLLLYQFLILVSVFSSYPTVSDNLIYLCLLPVFISLHKYLRWELIIGGTMVSCLILAPIMWRMWVTTGSGNANFYFAIALCYSVAQILLLTDLLYAFVRQEANKNRNLTETDNVSLFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UER1</accession>
    <name>A0A0N4UER1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9407</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UER1"/>
    <dbReference type="STRING" id="318479.A0A0N4UER1"/>
    <dbReference type="WBParaSite" id="DME_0000588301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000588301-mRNA-1"/>
        <property type="gene ID" value="DME_0000588301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5909522at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF3">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="112"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="399"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000588301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65775" checksum="11CDFFE524A76F03" modified="2015-12-09" version="1">MQNIVNIINNTRPKIIHESDNDVSNVSYQMADKLLRKMRSFTSDQRTSEEQKISSDSGKFVITNVVGMGEKESNRIFANICDSVPLATSTVKPVPTPPDFPDQCAPNLITRDFILVIDMIPNPIQAYKFTELESFLKRFGTNLLTNPTNNQIMLIGYDSLNVLKAYSFTNSLQKYFDNLEKLINDTSRATMGHYGRLSSALTYVAEKNIGLRAYTEAFIIIIADHVPADDDTTLNSARLSITRLQRSGFYLSAITPTKGPTAHAFSHLIFNQKWLSKERVTDYSHLPNEGNKFAMQQACSYIEIVPPLGQFTTPARQITTMLSKSKKPSTTNKSITSKSHTKLDEESMIVKLLSNKITNKTADEITESVYNATSIIDTNITVSSLITIIPPSKKIDCMNILIILDRSQSISENDYNQNVRNFVKKLANNIAFEPSSKGDRNRYSRVGVIQFAYSAQNDITLESRSVDEFEKLVDERINYTKSDGTYSGYTNTAAHSMFTDDPIPIAQKLREAGTIIICVGLNGTNGDYTTHNREELLKINGNRTDLLFEVYSKNLTNDLSEKIIDNIPCPGDVPGLHRTIPPYYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEX9</accession>
    <name>A0A0N4UEX9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="3">1.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS898</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEX9"/>
    <dbReference type="STRING" id="318479.A0A0N4UEX9"/>
    <dbReference type="WBParaSite" id="DME_0000595901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000595901-mRNA-1"/>
        <property type="gene ID" value="DME_0000595901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000100">
        <property type="entry name" value="Glutamate dehydrogenase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="254"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN50925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000595901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61284" checksum="D68EB28607B8A54E" modified="2016-06-08" version="2">MLSVLRNAKLFLTPVRCIISMSDTEKLADQHLPMDEQVNPSFFKVSYRTQNAYFLQMVDYYFDKGSSVLAPRLIDEIKSPNMNQNDKKNLVRGILSAMKPVNKILYITFPIRRDNGEYEIIEAWRSQHSEHRTPTKGGIRYSMDVCEDEVKALSALMTYKCSVVDVPFGGAKGGVKIDPRKYTDYEIEKITRRIAIEFGKKGFLGPGVDVPAPDMGTGEREMAWIADTYAQTVGHLQNDASACITGKPIVAGGIHGRTSATGRGVWKGLEVFIDNEEYMSKVGLTTGFKGKSFIIQGFGNVGLHTMRYFHRAGAKCIGVQEWDCAIINPDGIHPKELEDWTIRNGSIRNFPKAKIFEPFTDLIFEKCDILVPAACEKAIHKNNAARIKAKIVAEAANGPTTPAADKILLERGDCLIIPDLFINSGGVTVSYFEWLKNLNHVSYGRLTFKYEKDSNYHLLDSVQESLKKSLNQTVKIEPTAAFKDRIAGASEKDIVHSGLEYTMQRSGNYIIANAKKYNLGHDFRTAAYALAIEKVYRTYRTLGFTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEZ3</accession>
    <name>A0A0N4UEZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Letm1 RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS914</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEZ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UEZ3"/>
    <dbReference type="WBParaSite" id="DME_0000597501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000597501-mRNA-1"/>
        <property type="gene ID" value="DME_0000597501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="624114at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="17">
        <location>
            <begin position="188"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN50941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000597501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65156" checksum="3A2AC210CE82ABA9" modified="2015-12-09" version="1">MLRRIVAVVVSTRNSSFPSHPRIRLYSSRNLLRERKFQAFDMIRYASTEKTKVEKTLEMLKDDLKQEQSEKDRSKERDLNKTIAIKVPLTKRIMNELKHYYHGFRLLALEVRLSSRYLWRVARGHSLMRRERQQLVRTVSDLFRLLPFSVFIIVPFMEFALPLFIKLFPNMLPSTFKDATKEEENLRRKLKVRLEMAKFLQDTIAEIGLVRKSQSTDQSASKAFEFAEFMKKVRTEGGYVSNAELFKFTKLFEDELTLDNLSLSSLRALCRMLDIQPLGSPEILRFQLNLKLRELKADDKQIALEGGVDVLNINDLQTACRARGMRSFGMSEFRLKSQLKQWLELSLNDNVPPSLLLLSRAIYVPEDITFADRLKALLSSLPSSIAEQARQKLTELEGDKINYKARLDLIREIEIGLQKERESMEETKKIVVESKLVADNTSTLLGSEPIVSGAEGVAAAEVGVKQPSVAGKDLETLENIIHGGVVLEAKHDIDELKEKLSGRREDLMEVDALMNDLTETKGAKILHRRINHIIANVDSLVAKLEEKRRHIAETVADPAIEDENKAKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF69</accession>
    <name>A0A0N4UF69_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF69"/>
    <dbReference type="STRING" id="318479.A0A0N4UF69"/>
    <dbReference type="WBParaSite" id="DME_0000606601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000606601-mRNA-1"/>
        <property type="gene ID" value="DME_0000606601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6357832at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034518">
        <property type="term" value="C:RNA cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901190">
        <property type="term" value="P:regulation of formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040160">
        <property type="entry name" value="Mxt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000606601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8869" checksum="E1A89073AE79E768" modified="2015-12-09" version="1">MAMSVLYNKACCRDNGQLGTPCRLKMMELVELRAMGWRPSLAHTQYYLNRPEHQSPIGGPSFAFFQNILRYVRYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG04</accession>
    <name>A0A0N4UG04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9507</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG04"/>
    <dbReference type="WBParaSite" id="DME_0000639601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000639601-mRNA-1"/>
        <property type="gene ID" value="DME_0000639601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872298at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000639601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58810" checksum="1DC92C732B292B58" modified="2015-12-09" version="1">MDVIKRYYEKVQESCFAVVECRSSASAPYLMFINTIFWLSAFYLEREIQFRVLLSLAVDVLSKILFSIGNQLFQALGVTLAFLSAYSLKVDTEKACCCVYIGQSYVALSAIQSENSFIQNIIRKTGDFLSNIWKNFILSIKNLCILIKCKVKNALIHLKQFIICIAISIKNYIIHKLRSCKEWIFGKLAQVRDWICDKFIRPIRNALLSIFQFLRYYLCGHWWPGLKAYLVDHIGRPVKRLFNYICFATVYIFCGYWVTPLFKLIIRYLQRFRKFIFRTCIAPIVRYMKYLLSQALIAIRRVLHQLGLIVRDSILWPFCVILFEFLKAVGLIFHAIIIQPCCNYFYTKYKKCEDCLLIYVLGPVCKIIVDNDTDTELAELLPIREDNISETENLSEKQSVESRSSISFYKYTFAEDEHDFVRGLKFPSLITSESSDENLEAFKPLKKKHKRKRPSKTECLKSVPKDPTPSVIADGKSDTSSENSRSSTTFSLNSGNNHRDLDELVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG58</accession>
    <name>A0A0N4UG58_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9568</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001185">
        <property type="protein sequence ID" value="VDN59595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG58"/>
    <dbReference type="STRING" id="318479.A0A0N4UG58"/>
    <dbReference type="WBParaSite" id="DME_0000645701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000645701-mRNA-1"/>
        <property type="gene ID" value="DME_0000645701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000645701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28630" checksum="DFA976DD35F7EAF6" modified="2015-12-09" version="1">MISIYQNGQNNDLKCEKCKKNEAKYKIKPTHCIYCQLPAAFVDNKCVWCSYGERKTGPPVPCVKCKIKSAFPKDRTSSDATWICRLCSLLNKTNKSLGKRKSSDLGRISQYKRNNEKSDHKNKQHKVTFSTDLNSEQVQSEHILVVQQYKDEISSLRKQCSEKDRLILERDKKIAALNAEILCNEKEGKQKVLQLQRQHTDAIQNLHEQIRSLTKQLEILYVLLQWRKVSYCLPIGWRMIRKSALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG99</accession>
    <name>A0A0N4UG99_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9616</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG99"/>
    <dbReference type="STRING" id="318479.A0A0N4UG99"/>
    <dbReference type="WBParaSite" id="DME_0000650501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000650501-mRNA-1"/>
        <property type="gene ID" value="DME_0000650501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846646at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000650501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16026" checksum="04FCA8907EE03B2C" modified="2015-12-09" version="1">MKFDLSLFHFDFSVVHRYFLFFQCMFSNTLMIRFRSKIGTTFVINEMKFLRNDCDITNLSCLILFCGRSFDSLQVLAWHMSYAHQDISINSKANATCFLCGFKMSTAKVIFAKMPAASITRIFAEVYSCGESNLSISAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGB0</accession>
    <name>A0A0N4UGB0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9631</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGB0"/>
    <dbReference type="STRING" id="318479.A0A0N4UGB0"/>
    <dbReference type="WBParaSite" id="DME_0000652001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000652001-mRNA-1"/>
        <property type="gene ID" value="DME_0000652001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000652001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29030" checksum="3BF65F676E69B0AC" modified="2015-12-09" version="1">MFTNSAVDEVPKLRTARNMESFYLCYQCGETFWSKSSYDEHLFLHQLFEIRSKNLLNHRNRESFSSGYKPSTKKSAFDEKIKRRNTVDVVPVSQKSSDLNVFPRRKITHPLPDSLINISKKPMIFKKYPRIGDRTDVLLSKGKDSTQTEANQGSKGKEPHYFAAESVVDSSKQCGVDLKISTASNDDCNHKFQLQETTITNKNLCGDISAPLGATKIAAQLLQKCLICKYRSSQGGEMVEHGNVKKTKDKNKKATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGY8</accession>
    <name>A0A0N4UGY8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1394</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGY8"/>
    <dbReference type="STRING" id="318479.A0A0N4UGY8"/>
    <dbReference type="WBParaSite" id="DME_0000678001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000678001-mRNA-1"/>
        <property type="gene ID" value="DME_0000678001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="349"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000678001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56880" checksum="745AE560508D0E1B" modified="2015-12-09" version="1">MEALNVFLQRNKLYAILKHLLTPGRYYTFRVAAVNTYGSLGFSNSSSLFKLSKEPRAPGQPRNLSLGKTTSNPDGLWTQEINWAPPASELPIKNYFITWYKSSEQQANVYEELLWKQNVEKQEKRSANHNDEDDPDNNDDFVDKERTSTVVPSYSTSALIEGLEGQSVYLTEVHASVDSSDGELHGEKAIIFIRTASSWTPITLSILSSTTPSYGPQEGVILESDSNLHKKEKISLLEVKTPYFEDGTLKTMISWLNSPHCSPMKTTFIVRWRLLACQLNDEKQKTYYDLDTSGQDWAEITVQQCVALLDELNFSCSYFLEIIDNVHFKTNSCEQTPSVTHKSCEIIDSSTALSCRASLDNPSAFCSWQAPQLEISRSEAIIGYRILLSAPLKAVEKVTINPPQARNVEFKGLERDTEYSVHVQTITSAGLGEVMRSKFRTFATLGNSEELNGIGFGKKSDRQILNDVFSAQEIIELPLETSASSVVRWLSTCCFLLICNFLSSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHV2</accession>
    <name>A0A0N4UHV2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9882</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHV2"/>
    <dbReference type="STRING" id="318479.A0A0N4UHV2"/>
    <dbReference type="WBParaSite" id="DME_0000715201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000715201-mRNA-1"/>
        <property type="gene ID" value="DME_0000715201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08782">
        <property type="entry name" value="Death_DAPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF18">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="7">
        <location>
            <begin position="177"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="6">
        <location>
            <begin position="785"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000715201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="908" mass="101218" checksum="3ACF1A9321243549" modified="2015-12-09" version="1">MVLQDNETALHCASFRGHIECVQSLLEIETININATDQNGQTALHLALQRSHIDIALLLITKGCELNVQDKNGETALHIAARFGLLSVVQTLCHLGASLDIISSNSLTALHIAAKEGHIEIVRCLCFFGADIKKKNKESLTAEIIALAQEHSDIGLLLAKMKSDQVRELYIEHLCPLETPLKRIKLKLFGHSGVGKTRLMCSLQTGSVIGSIINVVSRRFSDNLSSPSSSITSSPSKDEGLSNAEDLFEPSNTLKINQRYVTPHQQYTRGIDVQNLTFQGCGEFSVWEFGGYEPYHMAYDHFVGNTDCVHVIIYRCIDPTEVQYKQVLYWMNFLKGRVAPSEPIGHCGIISRRSKVVIVGSHANPSLFPQRNSDGEYISSDSDAMLKTIRLRFETHFDIYDKLILLDSTHSNCPGMKILKGYLCKSRDTILSRLPKSMGLLESCVQYLVGLRKQVAHFPVITWPHFTTLVRNDVNPLAGDSHCRQLIQQLQLIGEVVYLRDEISETDYVVLSPEWLGTHIIGNLLSAEFLSRCRINGCYSVDEFASIYPEITEPVDLLRILDTLQLCAPIDIDGETEFEFPAFNIQMVPRDVWLNDRPSFVYGGVRVLPMRGMERSLQSTFPRIQIALRRSMNDFQDPMDADLTQWAGCSKMSSGQMEALIRLHGDAVEIQVRGPCEISTSCFYFLEDITNLVEQTAQDVAPGISLERHFLSPKHLREHNSNPAVYAPETIMAMQQAESLIIRNNQEGEELFIDVVCFGSRDVAAVLTLGIDIGIAQLQLASRCELAALLDPADAMGRDWSILAVKLNLTDQLPEVDSTGQSLSRTDQLLAEWALQSPETATVGRLCIILDELGRQDAKDALYRTVPLYLFAPLIDQPTTQLVEYRDSGVVSSTHSTVDPCSASTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHZ8</accession>
    <name>A0A0N4UHZ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9 12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1678</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHZ8"/>
    <dbReference type="WBParaSite" id="DME_0000720701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000720701-mRNA-1"/>
        <property type="gene ID" value="DME_0000720701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000720701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51136" checksum="D5A3E9DA974EB4B6" modified="2015-12-09" version="1">MVNLMVQLITMIMLGDHLGEMNAKRSLENILRSMDHWPQRRVSEIIIDVSGDPQPRRASHLYSSLQSLLFGERNVRNTNITTTSSASPHTINNISDERVDMVDEVEFFGQFIQFEAWLCTYGQSAIKSRLRLKVKIIFANLQQKNMGSADDDFFEMLSRAQSKRINDQRCDPIILSDLTNRSKNIARQSDSIDTVVKRSSKTRRLSLIFDRVCQAATRRQGQTFFAPRTTSTPRPSMTPHKLLSPISNIVKEGNIAPINATFYSVPDDVDSLDSKAQLCTAQGSFVALSSEFRIPVAPPRRRNRHLDPKRLQSAQMLTQPVQSNISQNRILILDGAEGMLNLIASLQGRRMEEQRAHLNVASDTESLISSVATTEGKDDQISNRLERSRSEDAGVLYDMLIRSQGDRLEEQRSELPTHVPEDISHIVMTMQKGRIETQRAHLNRDHNDNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIH3</accession>
    <name>A0A0N4UIH3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10044</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIH3"/>
    <dbReference type="STRING" id="318479.A0A0N4UIH3"/>
    <dbReference type="WBParaSite" id="DME_0000740601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000740601-mRNA-1"/>
        <property type="gene ID" value="DME_0000740601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000740601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48627" checksum="FE637FB4A2ECE1C8" modified="2015-12-09" version="1">MMWFSGVLERFKELKFFRLISEKSWDIRRGRELGSTWANDNETFESEQSSGCCMNSSNTDCGLKGFVIRDPLLIAKFRADIRNARPLQPLRPLQPLALMHMRSLLPHPTRLEAPDRRPSSNSRNFLANLPDMRENKADSVGTNQASQTYMKTLYGCSRQPFYGSQDSEHIIKVNSTLANPCISYTNSLDRSAAFQRLESFGATNISGWGTVPCHMQPVIPLADIKFDTCHARMNLTNTYGYKTKFCRAWLKSGACALGIRCRFAHNIGELRPINDQAMNSVNMIHNTNFYNNNSTASGIYCANQTQHNCAYQKNYMDTENNCIQSEYEKALKTLESTESNAVPEITGVKISGNFQSEKSLSPSSFFRYCNGERFKMEDIAAGTLLQSNAICPTFSGETLMKNDVQLGEIPLTTNNFDETLQALKQFQRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ55</accession>
    <name>A0A0N4UJ55_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">molybdopterin molybdotransferase</fullName>
            <ecNumber evidence="3">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10105</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ55"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ55"/>
    <dbReference type="WBParaSite" id="DME_0000767101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000767101-mRNA-1"/>
        <property type="gene ID" value="DME_0000767101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051920">
        <property type="entry name" value="MPT_Adenylyltrnsfr/MoaC-Rel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764:SF1">
        <property type="entry name" value="MOLYBDOPTERIN MOLYBDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="5">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000767101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19630" checksum="C6C125A977D4050D" modified="2015-12-09" version="1">MNITVITVSDTVITGEREDISGSVLVSLVNNSKKLNAAAIHHYSVADNETEIRERLIQSSSISDVILTTGGTGFSSRDVTPEATETVIEKRCGGMEVALHLRSLQTTPFAALSRLCVGIRHKTLIINLPGSPKAVKECFEVCEEILPHAVHLIKGETTNVSSIHTVLQNHSEKEDSIFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJZ5</accession>
    <name>A0A0N4UJZ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA_28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2135</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJZ5"/>
    <dbReference type="WBParaSite" id="DME_0000801001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000801001-mRNA-1"/>
        <property type="gene ID" value="DME_0000801001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000801001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41728" checksum="52EA3398ABFC0A9B" modified="2015-12-09" version="1">MNRTFFEGLGWKVFTVPETATILQKGGVKFAELTAKQAYEFQKDLLKTLLTVESVFFKQAELCTHERILIICDRGAMDPSAYMDSKLWNKIIAELKFDQFSLREGRYDQVIHMTTAADGAVAYYSLANNAARFESPSRAIEQDHLTRDAWLGHPRVDVIDNVGCKSFEDKILRLVAAVCDRIGLPTQDRLSFNSKKRKWLIAAVDKLRMPRSEIFNIRHSYLCTEDVNIQVRLRSRSQNGRTTYTITTRSYNAPEPFETRMQLTWREYLNYKKMEDRCRAAINKERRCFMFGKQYFHLDVYKSPLPPSLRGKQLMLLETYTTAQVGNIEEPRLPDFMTVEKEVTGDPNYSMYIIAKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKK4</accession>
    <name>A0A0N4UKK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Mre11_DNA_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS2305</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000054">
        <property type="protein sequence ID" value="VDN52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKK4"/>
    <dbReference type="STRING" id="318479.A0A0N4UKK4"/>
    <dbReference type="WBParaSite" id="DME_0000827501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000827501-mRNA-1"/>
        <property type="gene ID" value="DME_0000827501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="17">
        <location>
            <begin position="333"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000827501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64814" checksum="1C6C3DCDA480E911" modified="2015-12-09" version="1">MQSQVPSESSSEYLKVLVASDLHVGYAEKNPKIGMDSYRTLEEVLQIALNNNVDFILLGCIRLLQISSTFYNEKMGMGTARMNNFILGGDLFHYNSPSRLCTHRVIRVLRQYCFNDRPVYIQFLSDPTVNFSHSAFSCVNYEDMNINAGLPIFTVHGNHDAPFGGGYTALDTLHECGLINLFGRFDSIDNFEVVPILLQKGKTKLALYGIGHQRDDRICRAFREEKIRFLRPQEDTDSWFNILVVHQNRPRRSTDRSTGAHLPENLIPSFFDLVIWGHEHECKIEPQYYENNPDIHGDGFYIMQPGSTIVTSLSQEESRPKHVFVITINERSFISTPLRLQTARPFLFDNLIIDHIPPQGCSKHHRLERNMPDEKAVIEKIEKMLKQHASNEENQELLPLLRLRVHYPESWEDVKKLDNRSIWNHFTKSVVNVSDMIVIKTSSKVKGKKHNAELLRHIEKATTVEEIIEGHFNDVSKSCRLMVLSSSLLNDHMKHQNENEHKRNVKQDLLDCIRGEKERFVNALCKGSYGIEDMDISDKKNLYHEIEEKLTAEVEKARELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKW1</accession>
    <name>A0A0N4UKW1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2403</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKW1"/>
    <dbReference type="STRING" id="318479.A0A0N4UKW1"/>
    <dbReference type="WBParaSite" id="DME_0000839701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000839701-mRNA-1"/>
        <property type="gene ID" value="DME_0000839701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="417"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000839701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56876" checksum="DEC9C080FAD1F828" modified="2015-12-09" version="1">MIRIVVTNIQHSFVRNIACASNNITSCMGLEYNSNYSSRIAVVIDEGISLSYGDLAASVGSYVSLLSSKYSLSRGDRLLVKAEKSINILALYLATLRLGAIYVPIIPTYTSRETMYFVKDLEPRIFVTSDLNKDCIFINSTPYVVDLSMMARDASKYSPDYGMENVLPDDTACICYTSGTTGKPKGAMITHKGLKWNAESLIDLWRFVGSDVLLHQLPFYHVHGMFISLNCSLLTKSCIIWRPSFTVEDALKWLPMSTVMMGVPTYYSRLLKNQEFNVEVTRNIRLFVSGSAPLSSSLAADFHSRTGSVILERYGMTEAAVITSNAYDQNSRLVGSVGKILKGGEMRLSKTGVLEIRLPSLFSGYWRNPMKTQESFTDDGFFITGDIGRIDNEGNLWILGREKDMIISGGLNVSPKEVEDIVDSFPFVSESAVIGIPHSDYGEAVVAICVKESNSTIVDSRSILEQLKSQLASYKIPKRIIFLDCLPKNSMGKVQKNLLREKYKDLFISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL96</accession>
    <name>A0A0N4UL96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10407</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL96"/>
    <dbReference type="STRING" id="318479.A0A0N4UL96"/>
    <dbReference type="WBParaSite" id="DME_0000856001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000856001-mRNA-1"/>
        <property type="gene ID" value="DME_0000856001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5814005at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160398" evidence="2">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000856001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="24227" checksum="36E5BE7322F8AD9F" modified="2015-12-09" version="1">MFGLLIVCYLLCVAESGDLSAEIVDCKGSAMAPFKPVPPPSACKNKDETICVAVFNPLGSDAENNANPANTYKVNANCLNATLKANALALCPSSCALCCMAPEFSCNNAVGADCTPFTVSSDLCTNSQTAAAALANCPKACGLCNRPGAGGRCPNAVTNCATLLPVLTCTNAYMQQNCMETCRITTCLSTTGGASSSCSDVRANCAQMVSFCNVPPYSVVMREQCRRTCNICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULA0</accession>
    <name>A0A0N4ULA0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10411</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001216">
        <property type="protein sequence ID" value="VDN60438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULA0"/>
    <dbReference type="STRING" id="318479.A0A0N4ULA0"/>
    <dbReference type="WBParaSite" id="DME_0000856401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000856401-mRNA-1"/>
        <property type="gene ID" value="DME_0000856401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868199at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041160712" evidence="2">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000856401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="28806" checksum="3A2690541BEB61EE" modified="2015-12-09" version="1">MFSLLIVCYFLRVTESGLSLDIADCRGSPVAPFRPVPPPSACKNKDEAICVAVFNPLGSDAATNANPAMTYKVNANCLNATLKANALALCPSSCALCCMAPEFSCSNGSDAATNANPAMTYKVNANCLNATLKANALALCPSSCALCCMAPEFSCSNAAGADCTPFTVSPDLCTNALTAAAALANCPNACGLCNQPGAGGRCPDAVTNCAALLPLLTCTNAYMQQNCMETCRITTCLSTTGGASSCSDGRANCAQMASFCNVAPYSGVMREQCRKTCGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULB7</accession>
    <name>A0A0N4ULB7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10432</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001217">
        <property type="protein sequence ID" value="VDN60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULB7"/>
    <dbReference type="STRING" id="318479.A0A0N4ULB7"/>
    <dbReference type="WBParaSite" id="DME_0000858501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000858501-mRNA-1"/>
        <property type="gene ID" value="DME_0000858501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994231at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000858501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31247" checksum="A7E1D169DBDA5DE4" modified="2015-12-09" version="1">MSNLNGSSAVPSASKKRTSQRIKAHSSGIVLRRTSARAAALSNKSLTGTRKTLENTVFNKYISRRTSLFKNTLPLKAPSLRATMKTHESLFNSKGILFRVGDIISAIDKENGKKYFAQIRGLLTDIYAEKSVALNWFVPLASAADPHIFDAEHFVHAVSDSKFYKLETLDSECLSRFISYDFANQRCCLMWKMNNYPLPNRELLAIIGHTDYGQDCTFLQHVPDLPEYRWKWSPLTCAMDQLRSELCERWKNIRRLDNIQPSLMDKIGIKDDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULJ9</accession>
    <name>A0A0N4ULJ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2592</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULJ9"/>
    <dbReference type="STRING" id="318479.A0A0N4ULJ9"/>
    <dbReference type="WBParaSite" id="DME_0000867701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000867701-mRNA-1"/>
        <property type="gene ID" value="DME_0000867701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000867701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="48906" checksum="B2DF63E15595050D" modified="2015-12-09" version="1">MSKSEVDETEVKQELVDYVIVAETDDGEQIELPTLPEDGSLGFSTLTHAFPGAHGLKYKTANGVSRALLIDPSGTRFFPPADGWKGKTFFVIYSQSRGPGDQNTKRKKMMDESDDGSSADDIQGGAKQKRLEEPPEKTSTDLIVLGIPFKTTSETARAYFETFGEVVMFDLKTDVAGNSKGFGFVRMKDYDAQLRVLAKPIHEIDGRRCQVRIPLSKGEANFPLVARIFVGRVPEKMTTEDLKSFFNNEAAKIDPSATVKLVTDVFIPRPFRSFAFVNFSSGVVAKEIIRGGDYIINGSSVAVSAAAPREPDYSPRVPQKIMYGRNRSNASFSRKHHAPFETFPPDSQSMYYDNFDASDNWRVGAYRGSDNRGSNRFSPGYSSTSRYGSNARSGTSQALASGLDALNLNKMNVNPEVMDAAWQAFWSTLNNNGGGSSSSNPSSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULX3</accession>
    <name>A0A0N4ULX3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2696</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000075">
        <property type="protein sequence ID" value="VDN52723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULX3"/>
    <dbReference type="STRING" id="318479.A0A0N4ULX3"/>
    <dbReference type="WBParaSite" id="DME_0000882001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000882001-mRNA-1"/>
        <property type="gene ID" value="DME_0000882001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.90.10:FF:000001">
        <property type="entry name" value="Tubby-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000882001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47631" checksum="E280D3F38E5608ED" modified="2015-12-09" version="1">MANKFPNYFLNLFFFLQRKILEEKQRQKRMYSAGIRQNDAMKDSRFGTSKSANKELHGYDGPLSFGITNMEDPDQITSPVFHGRTIITVRGVTPPPAQCSSDDDMPWKETTEIATSYTDNGKNDASECDEEPLVEPSREEIEENILAGTEHPDVNEIITNLEQFVKMPARRNITFKCRITRDKKGVDKGIYPTYYLHLEKDEDKRVFLLAARKRKKSTTANYLISIDPTDLSRLGSSFIGKVRSNALGTQFTLYDNGENPKKASVVGNDVRQELVAVIYETNVLGFKGPRKMTVLIPGICDTENYRRKEIRPISERDTILEKWKNRRTEELITMHNKNPVWNEDSQSYVLNFHGRVTQASVKNFQIIHDAHPDYIVMQFGRISDEIFTMDFRYPLSPLQAFGIAMTSFHGKIACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM31</accession>
    <name>A0A0N4UM31_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1990 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000077">
        <property type="protein sequence ID" value="VDN52757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM31"/>
    <dbReference type="WBParaSite" id="DME_0000888401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000888401-mRNA-1"/>
        <property type="gene ID" value="DME_0000888401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000888401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35212" checksum="7C996581830DDB56" modified="2015-12-09" version="1">MVALLDFGQFSCPLSCEQSPSSSSDADHGRDLNAARLLELAIQKRRAAFTSRRRDFRREIAHTVMVRTLCRRLGAELAMKRKKRLDRAKRLVQSMKCKSDCILHGEEVLMKSPLSNTRENYAMKGKSTNHDAESSNVRNMENTKYYHEDDPFDLDRLFEEAGYLGAETRLKQTLTHWISVSLSSLNVGCCSKCEYVARTGWFSVEQSHGEASATKVGRICGFHRVDYEMEGGMGTWQFSAIGPRLIHEESFRMDIVIPLFYVRCKTDVFHLCGFRYPEKNVLNRTEVWIKRGFTRSARAWMTLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMI5</accession>
    <name>A0A0N4UMI5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10584</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001226">
        <property type="protein sequence ID" value="VDN60611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMI5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMI5"/>
    <dbReference type="WBParaSite" id="DME_0000906301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000906301-mRNA-1"/>
        <property type="gene ID" value="DME_0000906301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861309at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027844">
        <property type="entry name" value="INTS15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14540">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14540:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14964">
        <property type="entry name" value="INTS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000906301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41131" checksum="1DC5B5CB152B27CD" modified="2016-06-08" version="2">MDRRVGSALTAPGVTKGTTGTITKFCGQQYCGKWRTGSVMRNNELQHLIDNDLFCISADRRVSRLNSMQQLRLLQILCDYFNEKESIARGHQYLFFETVFCGREGESLLHEARISLLIKLCSLAIQYPCYLLLNHVSQWLHKIGSAKSYAQQFISYLTDHFVMMPSEWNLHSYLIPLADEAPEFVSYFIAYSVSKEALKKELITVLTSWLTGRRSSRIIVFIKETPAVAKQFASSVNFYFLVLQFFLVLFETFAHLVFYDCIMGGSPQNSMHGITTILYADWDSSVPLNFLSALEVLFIMMLNEDETVFDEKILRFHIHLARKSKVLSSKEFFEFCSRPNLNANIRSILDMIKTQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNE1</accession>
    <name>A0A0N4UNE1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-dependent secretion activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10651</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001232">
        <property type="protein sequence ID" value="VDN60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNE1"/>
    <dbReference type="STRING" id="318479.A0A0N4UNE1"/>
    <dbReference type="WBParaSite" id="DME_0000941901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000941901-mRNA-1"/>
        <property type="gene ID" value="DME_0000941901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000941901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41245" checksum="BDCC57F6276ED486" modified="2016-06-08" version="2">IQRKHSQNTLSTKPILTQSSQEISDDDFNEDNDDDNFDDNATDDYTSNDHSTPAHIPAETTAKFSKEEEERLRIEVEEEDRKRKLQLYVFVAKCIAYHFNAKQPTDMTRRQMKVSKQELGRIRERFQIFLKGETQIVADEAFIKAVDSYLEVFLKSERVQKVVLAGGFSHFDFREVFRSNVEKRIRSLPEIDGLSKETVLNSWMTKFDTIIRGDEDAVQARQSRSRLRTANQTNTDLTLLKDQLYDVFQQILSVKKFEHQIIFNALQLDNPDEQAAAIRREVTTREEALRDISKMKKLMPKFVVKDMETLFIDETRQSINLLISNLESVPVTPRSQGIGSKKKNARGRNRCVLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNI8</accession>
    <name>A0A0N4UNI8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3147</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNI8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNI8"/>
    <dbReference type="WBParaSite" id="DME_0000947001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000947001-mRNA-1"/>
        <property type="gene ID" value="DME_0000947001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906921at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000947001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="36009" checksum="792396E9B11733BD" modified="2015-12-09" version="1">MQLSPLSSSKECDCFSELLKRISNLRRTQITFEGDLSIVNNQEEKWCNLFTNFISGKRYCTFKSCTIRNDDDMLWYVPYQRFNQNFTVDLNNTRLLVFRRQSPKQPIVGDRNINWEETVCLNLILQQLDFHVTCAVCTKTSPQNLQILRKNFQRVYPSPSRRRMDDKGEKEEITFPKIYFAIDDFEQMSRFFSSFLAFSDMVIRDGECVCVELVAKDRYKHREAVVFLGSIRYEVIKQVYDSRASSKWQWANKFIAKSHRRFEFVRMRGPHGKGYAEMAVARVLNCGFETPLVEQEINYNVCSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNL1</accession>
    <name>A0A0N4UNL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3180</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000111">
        <property type="protein sequence ID" value="VDN53207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNL1"/>
    <dbReference type="STRING" id="318479.A0A0N4UNL1"/>
    <dbReference type="WBParaSite" id="DME_0000949401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000949401-mRNA-1"/>
        <property type="gene ID" value="DME_0000949401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5916656at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000949401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47032" checksum="6FAF265DBE215401" modified="2015-12-09" version="1">MNGQKRVKRILPLTLKVKILDRLVRGEGSSAVARDYGLNESTVRTMKKNEERIRASAAANFLARSGGINCANIAQTSFYTRDSIIERMEESLNEWIEQQNLAKIPIDGSQIREKARQIYEFFKLQDEMNDSDNSATPKTASTITNARRRQLSHFVASKGWLAKFKSRYGLHTSKLAATITRRTPTSPLTSAHSSLISSNIPQFPMVNLANFIRQQNSSSSSSIAATTTTTTTTTTVDNNDYCEENQNDEQMDNNRVLDLQTSNERLNFLLQATFNETNRLNQEFVNEELKDEEFVHEEAKKGDFHDEHCETQAKTINNNNSDNSDNDNDDNDDDDDDDYNDNLVDSILTPKLTLKKLENGFRLAKKLEVFFLTEDQCTKRSLKFKTDLELALSQYRQLYRYLSRNSKRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW5</accession>
    <name>A0A0N4UNW5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3276</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000119">
        <property type="protein sequence ID" value="VDN53303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNW5"/>
    <dbReference type="WBParaSite" id="DME_0000962601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000962601-mRNA-1"/>
        <property type="gene ID" value="DME_0000962601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275057at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000962601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="540" mass="59640" checksum="0BFC46D566E575F5" modified="2015-12-09" version="1">MRGTPVIVLNQSTQRESGHSVQLANINVAKTIADVIRTSLGPRAMLKMVMDPMGGLVITNDGNAILREISVKQAAAKSMIEIARTQDEETGDGTTSVIILAGEIMSQAAPFIEQNIHPTVIIQAYRMALDDMLILAEKKFSRTIDVNNDEEVAIVVKSCLGTKMLSKWMDLAVKVALDAVKTIKRDIGNHMEIDIKRYCRIEKIPGGRVEDSCVLRGVILNKDVTHAKMKRKIEKPRVVLLDCNLEYKKGESQMSLELMREEDFSKVLEQEEQVIHQMCDDIIRVKPDVVFTEKGISDLAQHFLVKAGITGIRRVKKTDNNRLARVTGATIVNDTQDLREDDVGTLADLFEISKIGDEYYTYITSEKTKAVTLLLRGPSKDIINEVERNLQDALSVVRNVFINPRLVPGGGALEMALSEKGKSIEGVRQWPYKAAARALEVIPRTLVQNCGGATVRQLTALRAKHAQATENWTWGINGCTGELIDMNELDIWDPLSVRLQVLKTAIETSVMLLRVDDILSGVKKLSGDDTGASGGATQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPC2</accession>
    <name>A0A0N4UPC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IGFBP N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3394</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000129">
        <property type="protein sequence ID" value="VDN53421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPC2"/>
    <dbReference type="WBParaSite" id="DME_0000979801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000979801-mRNA-1"/>
        <property type="gene ID" value="DME_0000979801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835611at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGFBP N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000979801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12467" checksum="34940293DE2DFC18" modified="2015-12-09" version="1">MFMPALSAVIRSAYHLQWSQYFNGKVNCSIECTKKCPEVSHCTEVIYDPCDCCPICIRFINESCGSGIGICKENLRCRQDDPNIDSGICVGRLNLILYFICLIFNVLCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPQ4</accession>
    <name>A0A0N4UPQ4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Density-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3502</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000141">
        <property type="protein sequence ID" value="VDN53529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPQ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UPQ4"/>
    <dbReference type="WBParaSite" id="DME_0000995101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995101-mRNA-1"/>
        <property type="gene ID" value="DME_0000995101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19948" checksum="F9C2085EA0E65BA4" modified="2015-12-09" version="1">MSENGGEIVSGNATVSYPIHVKYCGACTLPLEYCEYSGMVDKCRKWLEDYLPNEFDKLCAGNEETAESEKKHQKRGGKGLKSTEKMESDKSKKKVLPKVTLQKSSRGKNKSVTVVKGLALFGVDLKAAAKLFAAKFACGSSVTAPDEIVVQGDVKDELLEVITGKWRQIDEGSIEDLGDHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ45</accession>
    <name>A0A0N4UQ45_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS3642</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000162">
        <property type="protein sequence ID" value="VDN53669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ45"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ45"/>
    <dbReference type="WBParaSite" id="DME_0001011201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001011201-mRNA-1"/>
        <property type="gene ID" value="DME_0001011201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN53669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0001011201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16695" checksum="F4AF04DBC15346EF" modified="2015-12-09" version="1">MDGPPPSYSDAIKESGDAGSDFSNLHVTNTVNGCMNGLSPASNFISPLMQPAMSNSASQPASTVPDFIRVTTPVFGPNPIEMDCPYCQAHIVTATQHIAGILPWIIVGLCFLLGFFLLIPWCLCYFVFCIDSCLDVHHFCPSCRRFLGRYSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ97</accession>
    <name>A0A0N4UQ97_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA_pol_alpha_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3683</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000168">
        <property type="protein sequence ID" value="VDN53710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ97"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ97"/>
    <dbReference type="WBParaSite" id="DME_0001017301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001017301-mRNA-1"/>
        <property type="gene ID" value="DME_0001017301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866399at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001017301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44977" checksum="E508B8548C7107AB" modified="2015-12-09" version="1">MSSSSDDEIILNKRRNTNQRASNRSRLPRNSETVSKALKEIKEARLSGKFRRIDVDSLIKPVYEEVDEREYLNIKRQRQNDCFVVDDDGNGYIDDGDDFSSENEYLDDVPLKQKEGLNSMLSFEEEDLRELLRWNENFYRLFFAERHKKNSIRSYFSDVAPKNIKDENSISLRNDPEMVSMLNQFFDNQLEFDPEECGVQSSNPYLRNPFKRELSRPSEDISPTPVKIAKISSPDKMLDDKKAIVNSEALEFGRKYGQKENFCVNSEHNNIILDDNNSAQSDGKNSLSLHSRDLFIEARIHHPLDKNVKYDLKTVTGDSETNHGSICSIFVPDDDNDILEVEVGAEGPFNENSNDKTVLRFYWLDTFEDTSKNPGICFSFLFPLHFISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQX7</accession>
    <name>A0A0N4UQX7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3896</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000211">
        <property type="protein sequence ID" value="VDN53923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQX7"/>
    <dbReference type="STRING" id="318479.A0A0N4UQX7"/>
    <dbReference type="WBParaSite" id="DME_0001044001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001044001-mRNA-1"/>
        <property type="gene ID" value="DME_0001044001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6150645at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001044001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28463" checksum="A0BB949F75222C51" modified="2015-12-09" version="1">MTSASLDASDIPSPVIVSNTSNPPSLALSISSTCLIEQHFGKSWNVTSEKIIRPIRAFYQHTLAQVCVYGELTDSFEIRTGFRQGCVLSLTIFNYAIDWVMNTACRHSRGVQISPENSIIDLEYADDVVLLADRYDEMHTILNNASSTVGENGLRIIINKTIVFSSFYIEADKIPIFINSLSAEEALDFKYFGYTPIPNSHAKDETITRISTVIFPVDETTMEPSRNHHEEENPRPYDCETWSIRVEDIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR42</accession>
    <name>A0A0N4UR42_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10917</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001274">
        <property type="protein sequence ID" value="VDN60944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR42"/>
    <dbReference type="WBParaSite" id="DME_0001051201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001051201-mRNA-1"/>
        <property type="gene ID" value="DME_0001051201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001051201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10939" checksum="46201A2516977814" modified="2015-12-09" version="1">MLRIVVIFLGHSTVHIIFKDPLIDCASKIHGFKTLCSTTMAFHAFFRAQHPHICENIQLMPIEMEATERKVASIKPYAPLVYMIQQRNNLRDAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URK8</accession>
    <name>A0A0N4URK8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4101</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000292">
        <property type="protein sequence ID" value="VDN54128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URK8"/>
    <dbReference type="STRING" id="318479.A0A0N4URK8"/>
    <dbReference type="WBParaSite" id="DME_0001069001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001069001-mRNA-1"/>
        <property type="gene ID" value="DME_0001069001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922186at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053032">
        <property type="entry name" value="BAH_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576:SF1">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="307"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001069001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54536" checksum="A7E116186C003000" modified="2015-12-09" version="1">MNDHIVNDFMNKVQTKAKPSFRIQTLIGDDDNVEGEENGRRTTHQVQMRKCCSFKVKDILGSQIAVESKGSEEKQNCSNVEQGIPSISSSKSSLINSVEIQKPKNIVNITNQEESLSVMLAEVNENRPPTPLTPSLDPKLLKKFEEEDRPKRVLRASTIAATRNSNLNAIKVKTNRRTGSFSTSFRRIVDNVKQNTTKNLRKASIKDNESAVTYNTQLEIKIDEDCEVCTPSTSGVSSISSTSSNGNFSRHTKRKKKGKGADLLTTTIISNWQPTGEGFRRPIYLRNDTMPVKRICFKEVRHRYEPEILRIGDSVIVKSDNSTTNLGRINRIYLDAQTGSLMATVVWYYKPDQIELDHNSVQPAIDCKELFASRHIDSIPLESVEEIIFVTTFNEYVRYMTENKIDSLPRAQCPTEEDEIWPRGEVDYPRRKFLPCEDTPVELVYFCRRLYDFKNKKLIFGTYNVKMAEPQRRHATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URV9</accession>
    <name>A0A0N4URV9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4191</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000383">
        <property type="protein sequence ID" value="VDN54218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URV9"/>
    <dbReference type="WBParaSite" id="DME_0001079101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001079101-mRNA-1"/>
        <property type="gene ID" value="DME_0001079101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="40"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001079101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="28877" checksum="76DE65B81BDAFAA8" modified="2015-12-09" version="1">MVVGVVVIIVAVVFIAFVTVIIVVVVGSVMIVVDIVSVVAAVDVFVVIVFAIVAIVVGIIVVVAVVVAVLDIMVLLLVAFVIAIIVVVVDAVIVAIVVVIIVVGVIVIIVAVVVIVVVIDVVVVGIAFVIVIIVVVVGTVIAAIVVGVRVTVVVVAVVVVIIVVGVVVAIVVVVVVIIADVVVVVIVFVVIIVVVVVGSVVIVVGIVIVVTAVDVVVVIIFAVVVIVVVDIIVVIVVVAFVVFIIAVVVGIGIVVAVVAAIVVVVIVVSVVVVFAVVVVVVISSPAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URZ4</accession>
    <name>A0A0N4URZ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10962</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001310">
        <property type="protein sequence ID" value="VDN60989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URZ4"/>
    <dbReference type="WBParaSite" id="DME_0001082601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001082601-mRNA-1"/>
        <property type="gene ID" value="DME_0001082601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001082601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14806" checksum="326F28CB24064287" modified="2015-12-09" version="1">MLVELAGNFVRASSYFVHVLYRCCISVGSGVIISLRGFIVSDRMEEKKKQKTFMRRRPSKSTSNPNAALAENTSIFAILLIFRTGIREVYNFNILAFVLCFDGVDLGLDANVAVNGAITSNKCVVITLQCKATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US40</accession>
    <name>A0A0N4US40_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4266</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000525">
        <property type="protein sequence ID" value="VDN54293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US40"/>
    <dbReference type="WBParaSite" id="DME_0001087201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001087201-mRNA-1"/>
        <property type="gene ID" value="DME_0001087201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033231907" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001087201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20159" checksum="96E59FACF6911988" modified="2015-12-09" version="1">MTIIAYLIILTSFCNLISGDEVDLNVCVKFVPTGPNPPNNMKRRPSVPVQNCQDRDMACPEIFKFMPNNGVVLANNLKPFTMTIIAYLIILTSFCNLISGDEVDLNVCVKFVPTGPNPPNNMKRRPSVPVQNCQDRDMACPEIFKFAQDVGVRLANNLKPLVSEHYFRFYFHFNIDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US51</accession>
    <name>A0A0N4US51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Evasin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4277</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000563">
        <property type="protein sequence ID" value="VDN54304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US51"/>
    <dbReference type="WBParaSite" id="DME_0001088301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001088301-mRNA-1"/>
        <property type="gene ID" value="DME_0001088301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041041722" evidence="1">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="2">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001088301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34795" checksum="10AB93BE25D00396" modified="2015-12-09" version="1">MIIAAVTLALLCCVGQSYEQIYDPLCIQKGRKCGNNMVYRVIDEVKYADDVSPKVICIVECTCINEQYERKNGQCIEKNNITKRNEAELPFEVPTTKACNGRTCTLDEKITDIMCSLTAQKCGPNMVFKIVNDPVRIKFGILSYKICIQQCTCDNNEYTKIDGQCVKKNSVSMRNEPEFGREILPKHCAGRVCALDEEIFNVPCSLTGKICGTNMIFTKIGKLLKKNGTEVCFQKCTCMSEEYVKANGQCILSTKGNETATPTSTQRSATESKLQPTMRKFSKTRSSKNCVGRTCERIRDLFCRSEVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US55</accession>
    <name>A0A0N4US55_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAC3_GANP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4281</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000574">
        <property type="protein sequence ID" value="VDN54308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US55"/>
    <dbReference type="STRING" id="318479.A0A0N4US55"/>
    <dbReference type="WBParaSite" id="DME_0001088701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001088701-mRNA-1"/>
        <property type="gene ID" value="DME_0001088701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001088701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="33012" checksum="FC14E31EB17CA29F" modified="2015-12-09" version="1">MHSAMISTLKFRLPQKIQFNSKFPANSHTVYTNFDRRPSRSFESRGRRNQLRSWWGNRSSNAGTRGLFHRRHQRDKISAEHFYRTPKSHKRSDILCIDESRPEIILNGIHWRFPNAKRKAEKSDDEPAQAKKKLIQNVREKPCKSLLKTDVVKQLKSLLGRICEQNYDKYFLLEERDKIFYKARIISNDMETTVAIQGTCEDMCSEKERYARIVQKRVSPYECNHLGEMIPKIAVKEYRRSAADQEGTSSARASPNSCSSFHDELPYRKGDAVEFDLLSIVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4USB5</accession>
    <name>A0A0N4USB5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4337</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000837">
        <property type="protein sequence ID" value="VDN54364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4USB5"/>
    <dbReference type="WBParaSite" id="DME_0001094701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001094701-mRNA-1"/>
        <property type="gene ID" value="DME_0001094701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001094701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24579" checksum="8C5977B1FFB2012F" modified="2015-12-09" version="1">MVQRFYISDKNYDQKTIVKSENVEFSTLMKEDWKKTKNFGCAKKLCFNKFSRIDLTICFYKLREAPANSRYAMKSSSGQNLPLQLKYDLENTTFSSEQEPSTNTSTQNNTVEMSTLDVNSSASQFESFDSDSSESESVEIETVSTYQPTTMETVSTHETTRLADTMQASLGCSKSNITVKVQERVLARHKTYRSTLEYVIAKMHGYLPYERREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2I9</accession>
    <name>A0A158Q2I9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4554</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2I9"/>
    <dbReference type="STRING" id="318479.A0A158Q2I9"/>
    <dbReference type="WBParaSite" id="DME_0000019401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000019401-mRNA-1"/>
        <property type="gene ID" value="DME_0000019401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434324at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000019401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11329" checksum="1E4CF4278C1FD155" modified="2016-06-08" version="1">MRKQPYIAFHRPLCFWNVSDCMKWLKGRHPKLAFKYANIFSKHHITGRILIEINDELLQDIGVDNFEDRQELLLEIQREKLYGDFDKFSKLSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2Z4</accession>
    <name>A0A158Q2Z4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5587</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2Z4"/>
    <dbReference type="STRING" id="318479.A0A158Q2Z4"/>
    <dbReference type="WBParaSite" id="DME_0000122701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000122701-mRNA-1"/>
        <property type="gene ID" value="DME_0000122701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000122701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36987" checksum="BB33345C2A26BBFF" modified="2016-06-08" version="1">MTMQGLNLKWISLIVLISQTSALVLLLRYSKTQKVDGPKYLSSTAILSAEFIKFFTCIFVLMQQNEWQFTSVKLEIHREFLINSKETLKVGVPAFLYVIQNNLLFLALTKLDAATYQVTYQLKILTTAFFSVSMLGKKLNALKWISLLLLTAGVALVQMPADYKSNDEEKISSFHLNSDRLIGLLAVLVACFSSGFSGVFFEKILKGSHVSLWMRNLQLAFFSLFGAAFMIWLYDWDKVVENGYFQGYNVVIWIVILFQAFGGLIIALVVKYADNILKGFAVSLSIILSSFISYWFLNDFQPTLTFVTGATIVIISTFLYGYEPKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3A2</accession>
    <name>A0A158Q3A2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Divalent cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6335</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3A2"/>
    <dbReference type="WBParaSite" id="DME_0000197501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000197501-mRNA-1"/>
        <property type="gene ID" value="DME_0000197501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="264"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000197501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46464" checksum="A2D6DA95B2930428" modified="2016-06-08" version="1">MNIPTESSYILFFQVLFPFLIAGFGMVIAGIILDTVQHWQLFIQVPETFILVPALLGLKGNLEMTLASRLSTLANTGHFDSVNGSWAIITSNLALIQVQAIVVAFLASGFAAILAWIPKGQIDWAHVSLLCASSLTTASVASLLLSLLMIVIVLLSRKANINPDNVTTPIAASLGDLTTLAVLSIFGSLFLNAHITESWLNVIVIALFLLIAPLWALIARHDRSTTDVLENGWSPIIFSMLISCTGGFILEAAIKKFQKIALFQPVMNGVGGNLAAVQASRASTFYHQTSQLGYLPFGWQLRRFTSFKRSFFSSDCDSRSARVLLLLVVPGHMIFNWLLQSLHGGDKSSFTPLFTSLYLLAALIQVIVLLFICQWLVSFLWVCQIDPDNAAIPYLTALGDLSGTFLLFVAFLIINWFIKYHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3B5</accession>
    <name>A0A158Q3B5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6440</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3B5"/>
    <dbReference type="STRING" id="318479.A0A158Q3B5"/>
    <dbReference type="WBParaSite" id="DME_0000208001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000208001-mRNA-1"/>
        <property type="gene ID" value="DME_0000208001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="8">
        <location>
            <begin position="123"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="1860"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1951"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="882"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1922"/>
            <end position="1945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000208001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2050" mass="232844" checksum="0A04E2B2F5290AA8" modified="2016-06-08" version="1">MNETGDVGSLIRRDADSTVRSSCDLVLRRDVDVVIKRDKPAMRGEESMVGSGESSIRTGEFSMKNGESNDRLVDYFVIIAYDQSQAHIAILCTITHDENVLQVLSAKECDRFLRKVLCNIEQDLTSFDIFHKGHGNSVGSILQRFPVEDWPNISLSSSLEVFSRPQGWSLQSDAKSPSFFVNTLTDILGSRQYSCCLQVYEPYGNVDDELDDSSFGTSNLFAPKVIVILSRFPFFDLFRHCLNQIHVALIDSKTDVESMIATLLSSINLAYGAPAVSFCLNNERYCVRAPLSPTVPVSSDKVVSFIRHMGTIHNVITLLCAVMTDHKILFRSSSLSLLSDSCFALRSLLYPFEYPYTYVPILPELLIEYLESPTPYIMGILDSFRIRCTDLDAIVVDLDVGAVHVPPSIVIPCLPQPYQQRLIHSLQMVLFPTLTTADNSWKVGQPPFPTNEVQDKRIRACFLRFFVDITRGYRCALEVVRLHSSPLIVFHKSAFLGARDFSSSSLIRTFLDSLLFQSFISERGLPFRICDLFDDVNLVNHLSFCENPSKVVLMENVLDITEKLLENVGFYFITEYQDSSYSVGSFLNNRCFSVPTAVTKLRNIAENKVTSLIEENLNKALPLCGSYSHPRKVPSPRIFNVESERLGVVSRRLQVLSGCLRHIFDMKLSDARKMLCAVELSMRSVNARVALCQLLWANITSANRAVLMPQQFELVVRLINCALSQESKEDEHGIAYAMLYLSNMYCRRLSAGVHQFAYTCIQDHFVWDNQQFWEAAFFHDVHRQLRRLYLPRKEDCDCPFPLKEHITDTWNLMERPSGLELASEILANITHFNEMQLKQKAIEENSIVYGQAKHYINLMVYMRTPLDVSKLRSVNTRELERRSNRQISKVDDDEETDSTESASDVESGFIEADSSDLGNSTVRWISRLIDRICSAAGLELQQIERLCREIPGFVALHIDNLEQVYMESKRLSPLQKIKLMQPALLFPAERIVINGLRVFLLNDGRSENIQGESIQNLLPAEGAIFLTNYLSEQTVIRTMPIASLVKEKQIGEQAIQNSSQLDGIPVRVAHQLHDVIQIRSSTFQLMKVAFDEEVSSQKAEEFTETVLSLRWPETHPHILFAFSAFLPTAVSNVSTKHKYGTMSELKRTFLRNPLKDKKRFRTPRKTLQFKNNIETMPASWNSSVSDYGKSLIDPSTASLHHHYLIDYDRIGLNHGIFRLSLANKRYDLSKGYPHIIVVPNSVNDEYFTKISKGFKHGRFPVITWKSEVGALLIRGAGLTSQTMVSRFKKQANLRNTMDSHILPSAADVFDPLTSHDFSSPSNIDLQEQYMSIFALLSPSERNQDGRLLLSQSIESLLSLDSLMTCDNRSTTSSGDLNKRYQNDFTRHAVNFVRGTSGKSTSQGSQAMSDYSGSLSGEQIPHYALRAVAIAKARELKQSLILTRCPLYIFGDSNQSKVLKLDKNCEFIPVTFPTAHDIKIAFKKFLRAVCPSWPAASDQLLDDASWLQMVSCILTLSNAIAEMIDVQHSSVAICLENGWDATCQIISLAQLFLDPYYRTFDGFRVLIEKEWLAFGHRFSYRANHSQTSQGSGIAPVFLMFLDAVHQVLEQFPTAFEFNDFFLRFIAYHSCSARFRTFLLDSEVERIKFDLLCLSAGDPRSSSIWTWINEKRSLSQIFENFAYLPEQTGIIRPQSSIASLDLWSYYSEDYLAHGSPYDIEVAEIEHQQREDERFETLAEANASGTVTRRRTLNSNYSCINFIALDSFSSYLEDHLRFRSLYDGENVERSESWKKIFNEADVRMMSKNSVQCSDEKENLLAMMKWRYHLRRTMQKKDTIKLLLRGVGHQHRLSRFRENDSCSGHQFIGQPVTPGDVCAVCHQSYPGTTVKNIHRCSGCGMTCHEKCSPIVSSPCPAMKVEIKNTTVSKNSPPPAVSPISEDKTLTPSGTRPHAYATHVGYLMKKGATFKLWKPRWFVLDCSKHQLRYYENENDLNCRGIIDLADIRSVDTTLSQTLKKPLLEIKTTRRSYSLLAESRSDAETWVEKILIAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3W5</accession>
    <name>A0A158Q3W5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7494</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3W5"/>
    <dbReference type="STRING" id="318479.A0A158Q3W5"/>
    <dbReference type="WBParaSite" id="DME_0000333501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000333501-mRNA-1"/>
        <property type="gene ID" value="DME_0000333501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="164"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000333501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40817" checksum="32AD094CA1F2E625" modified="2016-06-08" version="1">MAWAITSKLGCGMAKCHNNNGYPFMVHVVCHYGPRGNWDKTIYEEGEPCSKCSDYGRVCNGNGLCAAGDKPAEATHDDETPSEEPEEELISHEETEMPSEEHTEDESTMPSEEYAEDESTMPSEEYTEDESTMPSEEHTEDETTMPEETEKPDSSCSASKITSAGRENILKKLNDIRTKVAMGQFSTSDGTYPAAKEMYKLRWNCTLEKLAQKHVEKCKYDHSEYFHKYFYGDGVGESLFSKWTLDNNPTDDMLSVAVDEWLKSKPMGETSLSMDKYFETLNQDLAQIITARTTDVGCAVSFCEYAEHRPYYFQFVTCNYYPNGQQWSTAIYEEGGKCSSDKECTTYSPSKCLSEGLCERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4C3</accession>
    <name>A0A158Q4C3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8442</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4C3"/>
    <dbReference type="STRING" id="318479.A0A158Q4C3"/>
    <dbReference type="WBParaSite" id="DME_0000455901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000455901-mRNA-1"/>
        <property type="gene ID" value="DME_0000455901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825023at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000455901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1016" mass="115376" checksum="AC23445324159923" modified="2016-06-08" version="1">MNHANCSRTQWECNRSCRIQFVNTITGLCRRPSPHDTCFGIPIKYNYTEPIYTSYLSNYEILSRFPRCWSSLGPLMCAITYRPCANRSYFELTMAKPGKMEMWQVFRQSDCIRARENCAFIIQLGLWPDFLNCSHTIENNKAHLFSDSSCKMPYNKEPSRMESKQCLWPLIWSADDDNSGSRPIIDKCYLPCRSPLLSSSWLHSQFKLSLFICSSFMSLICILTFIYIAFFSHLWIINLCVYAIGNALFCAFMHWVLWITGFFNGFAQNAMCYEEFRKDIYMRSRILMEWCLIQSWLMHCFILSGFFWILLLIALRIRKPVISGDHLIKIDEHTAISYRCIFLFIYLLAGLFATFAVWMNAPESDGISGVCYVGLKNFKKGFYIYFPILIAFIIAIFIPFLCSCRKGETKLESELTCTTGLISENNSSAAQKLSSAKSELITGSKTGIICFSICLAISLSSITHFTLSMDEKDENHLILQSINCSLNKTIMEDEHEWFKKLEQSDSLVLDALERRQKISDGCTFLMIENVGNHSLHAPGCALPMINDGRLLLILLTFIVFPALPFLVLIAFVLSGFCGYGLKGINHIRKNLNPFVLDSLSESGDKGSNTTFEYASDLQKRSSSATEINRCCRLSSFGSQPHSEPNVKRSKRNRSRKLNLLERYAQEKKQYGNITHSMSNTQSSQPHSNYQMLNSSDICDWFHCKPQIDSELQSLYSCGFDGNLSGLNLTGTSSQMKTLSDPVDWKRFQSSAVLLAYQKGLLEGHWQERCNQYMGQIATLTENLKLADEELQRLTTLFCNKKSGTIEAESQTSVSAYICSESGNSSTMTKHHHSKKSEAMDYIDGSTVDDLNRVRSGSTKDCSTEVGSTRENSLVEESENSNTFLSDEEDSEEEKLFLQTIQKRGKVESGIEYGISQSCSTSSKDNTPSESTFSIVKSGTSSFSSPKHIAQQLSLTPDQQRQLTELRRSVTASDMLHLSDHFRLLAQRIRNQDMISSRTKNRPLTIEEAGEENDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q524</accession>
    <name>A0A158Q524_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Guanylate cyclase</fullName>
            <ecNumber evidence="3 13">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS1204</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q524"/>
    <dbReference type="STRING" id="318479.A0A158Q524"/>
    <dbReference type="WBParaSite" id="DME_0000630701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000630701-mRNA-1"/>
        <property type="gene ID" value="DME_0000630701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000044">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250240" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="592"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="928"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1170"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000630701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1191" mass="136308" checksum="0FC6C50A4B7A3403" modified="2016-06-08" version="1">METSCSFVFVICLLILSQINLKCKRCYQNNDNYKLKSNKLCYSKNGSIIGNSEEEKKEKTILISYLPAISQFPKNFFNSLKLMSEFDYLDAHDKDKNYGRLSDCFRTEFEGVHSSVISGALHVAVEEINANPRLLPSYKLAYVYNNTCGDEKLSTKFFMEHWAQGAKAFIGPEIHCRTEATMAAAQNLPLISFKCMDEKVSDKAKYPTFARTVPAQTEITAALISLLKCFNWRKFSISAIDLENSRFSVNERRYMIINISTVAYPFSEVAKSNVAQIISDTFKATRGYLYLTFGNVRLFRRILLEMGELGLMDDGDYVLVYLDPDYNWLNMYHAMNNHFFRNTLVPVSQSWDDMNSQDRKVVNFSKSVLAIIPTPVHLDTPEFIAFWEKANNYLSLFGVLRGEPAFSIKANRFACYLYDAVILYAMALTSVIEETTEEMLLNGYDPILDGRRIISKIIGRVYRSIQGFDMRINNNGDAQGNYTLLSLQKISPVMDKANPNYYPLEYGLTITADFIHDFSENLPIVRFKREMHWQNGHPPLDEPICGFLNEYCQAEKLLNIWKIDPRGIEKVVHCNESSTSLFLVGDSRASLLNYDEFNEKSRSGLCGVALYKGAIVTIEELGYSRKSKEIARATKLEMRIMRQLHHDNVNSFMGIILCNSSVCIVREFCAKSSLMDVLRNRDLKLDYLFIASFGMIYLHESELRVHGNLKSTNCLITSRWTLQVADFGLHELRDGQIWESEEAMWESWLWTAPELLRESECIRAIKGTQKGDVYSFGIILHEMITRQGPFMLIENNELCAKDVVLAVMKSSNYRPSFEGISAANYVIETMSMCWSEAPENRPEFRTTIRHKLKPMFSPIYKRNIMDHMMVMMEKYQNQLEDLVEERTSELHDEKRRTENLLQRMLPISVAQQLLNGKDVVPESFSSVTIYFSDIVGFTAISGQSTPLQVVEFLNKLYTLFDHIIKQYNVYKVETIGDAYMVVSGIPEAQPIEFHAEQIGTMALHLLGAIKNFRIPHRPMEQLKLRIGIHTGPCVAGVVGKTMPRYCLFGDTVNTASRMESYGQALKIHCSEQTHDVLINIEGFELEPRGILQIKGKGLMKTFWLTSRKNADFSMDEDCSMTEQQLAPEIFPRNTARSRLPSWIDDHCSSISLIGKETSLLRRIVERASSRHSSFDTTHQPQNGNDSSRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5M8</accession>
    <name>A0A158Q5M8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intron-binding protein aquarius</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1976</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5M8"/>
    <dbReference type="STRING" id="318479.A0A158Q5M8"/>
    <dbReference type="WBParaSite" id="DME_0000777901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000777901-mRNA-1"/>
        <property type="gene ID" value="DME_0000777901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002863">
        <property type="entry name" value="Pre-mRNA-splicing factor cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="4">
        <location>
            <begin position="139"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="5">
        <location>
            <begin position="364"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="6">
        <location>
            <begin position="581"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="671"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000777901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1312" mass="153239" checksum="269572D9CC4B5C7C" modified="2016-06-08" version="1">MESHFERIAYHYWAPFGLHKPFDASLILNIYHNELLKEDIFSQQKIVMLEISQYLERYLWLNFDPEKSTKEHIMSIVVMINEKYRERISAWQCIVERPDFFPEFFYNLLSLAYNTDESQLNFIERSAIAAFDDVINFSRFFNPLLHASNLITYSTLSSLIKSEIGDLFCQLMTMLKFYSRFEIDEITGEPLTTSQVLRHYKHITGLQKAAFMYFRESMKEFCLLNVSAIDSRKALLKQFGSMSNDDLYKFAEYLHLVKKLERSDSIPLGKQFLSEAVTLHCERRVNQLQQLNEQPLYPTEKMIWDENLVPYDEYNGHDVLPLNKLNLQFLTLHDYLLRNFNLFQMESTYEIRKDIEDTVFRMKPWIHESAKDQIIWGGWARMALPLQSFQFVEVSKPLVGEKSPAVVRADVSVNVPIRKDIRTEWEDLRKHDVCFLLKCRPKISVDGKYDTRKPFKDQIDVIYVRGCEIEGMLDSSGNVIEEYAAYEKKPHLTGDQRTFRVWLDENQYRLDLENDPEQSIDQIYHSFNLLVRRDPRTNNFKAVLSTIRQLLNTECVVPDWIHDIILGYGDAHSAHYKHMNNVVASLDFCDTFISYKHLLASFPSQKIVTSNDDPSLHPPPYRLTFKELEPQHNVDLSQRDTSIFVESYVVPSRGPYPHVEPRKNAILFTPAQIEAIKSGMQPGLTMVVGPPGAGKTDVAVQIISNIYHNWPEQKTLVVTHSNQALNQLFEKIMALDVDERHLLRLGHGEEALETEKDFSRYGRVNYVLKTRLELLNEVEKLQQSLEVPGDVAYTCETAGHFFLYQVFARWEKFESDVLIMSRNSSPDPSIIVKKFPFTKYFDDAPQPLFKGISFSEDWNIAQGCWRYIRRIFTQLEEFRSFELLRSGRDRTDYLLVKEAKIIAMTCTHAALRRKELVELGFRYDNILMEEAAQILEVETFVPLLLQNPQDGRNRLKRWIMIGDHHQLPPVVQNLAFQKYSNMEQSLFARFVRLGVPHVLLDRQDFIHNFYSEILFPLVYQFIFIALSLDEYRTMNAGFVFNYQFIDVPDFNGIGEETPNPYFYQNLGEAEYAVALFTYMRILGYPHDKISIITTYNGQASLLRDVVQRRCAENPLIGVPHKISTVDKYQGQQNDYIILSLVRTKNIGHIRDVRRLIVALSRARLGLYVLGRAELYRNCFELAPAFQRLYKHPLKLLLIPDEPFPSSRKVLEAVPPAQSLEIQDTIHMCRFVHELYAKNVDQLKISYKKHMKDYFEARQVRLFFFIFLTEAAEAAKTEEEKGVAEPAVDDNMEVDITFESMDFELQDPAKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5T0</accession>
    <name>A0A158Q5T0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2231</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01000051">
        <property type="protein sequence ID" value="VDN52258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5T0"/>
    <dbReference type="STRING" id="318479.A0A158Q5T0"/>
    <dbReference type="WBParaSite" id="DME_0000815501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000815501-mRNA-1"/>
        <property type="gene ID" value="DME_0000815501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6355886at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000815501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="24225" checksum="6A669D6F029183C3" modified="2016-06-08" version="1">MRKTIRETWSNELKNYQIKVVFVVAREELSNRFNNFTNDLINAYNENEIYKDILMANFIDRWNHLIFKYWAIMDYHGYFCSHIEYLAWLDSDILILTNNFLRFMKSIDEIHRNDLQCYVHYNAIPDRNGTSPYYVSYKQWPKPFLPIYCSGIFIMTSNESAEKISRTMPEFGIDYAASFRIFDVITGLIAEVPHLFFSNLGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6D5</accession>
    <name>A0A158Q6D5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3413</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000131">
        <property type="protein sequence ID" value="VDN53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6D5"/>
    <dbReference type="STRING" id="318479.A0A158Q6D5"/>
    <dbReference type="WBParaSite" id="DME_0000980901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000980901-mRNA-1"/>
        <property type="gene ID" value="DME_0000980901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849588at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000980901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27462" checksum="F987C1ABDFA58598" modified="2016-06-08" version="1">LPTIYHIFAQRVSVEYRSTIFSYLAASGSIGQTFAAIICPHLTWEVSFYLFGAIGLYWCVLWIKYSSDLPKSLSVQLLCQKTKNPLRSWDRFIFSSPLLAIYFAHFCMNWTTYVIMHWLPTYLRATLRTDSIGVSLAALPYLANSIFSIGSSIFFINWLISLSMGILAFNSAGHLSNHVDVAPNYAGITFAISNTIATLPGLTVGPFTAKLVIDSSGRWWPAFILAGVLNFVGAIVYVNYASVKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6H1</accession>
    <name>A0A158Q6H1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000157">
        <property type="protein sequence ID" value="VDN53642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6H1"/>
    <dbReference type="STRING" id="318479.A0A158Q6H1"/>
    <dbReference type="WBParaSite" id="DME_0001009301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001009301-mRNA-1"/>
        <property type="gene ID" value="DME_0001009301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873130at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001009301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26890" checksum="5B028C37E78EB2E4" modified="2016-06-08" version="1">MKRLSSTRSPKERKNFASNELTSRLEFKETELTELNISTFGTRHHTDFLYFKLGPMIRGIYIVSQINSDRDQFWKLECIGIHEQPYDYDDERALEQFKENIIRINPRQQEFEQYHRIIKNQLRSDIIEKIEPYMDQVLFRFRMLRKAIMADIEKAFLPIELHLEDRNCTRFLWLKDINKGVTEENLQCYRFKRVPFGVISSLFLLSAINYHLESRKTWRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6H6</accession>
    <name>A0A158Q6H6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3653</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000163">
        <property type="protein sequence ID" value="VDN53680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6H6"/>
    <dbReference type="STRING" id="318479.A0A158Q6H6"/>
    <dbReference type="WBParaSite" id="DME_0001013101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001013101-mRNA-1"/>
        <property type="gene ID" value="DME_0001013101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="465"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="958"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001013101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1301" mass="147125" checksum="1786BF18B72F4661" modified="2016-06-08" version="1">MAAFYVSNDDDADDDSDSASDSSYTIRRRSATVSPAAKKRYRHSSKTRRRSDVNLNLSNKNSFLQHHPTGNLCLLNFFEVRAKAHVEAIRKLINSFPIQASPSDQNQNDNAWHDEAENMPELVSDSDVDIIQTDIEELRDAAKSIQSLKRVLKIPSEIATKGISNNIPGTGSIRCSGIASRIGGHPRGVIQFLPSVKQRQILPALDTYRWNKNNNDLVIAKKNIFRRKTSLPETYLTFSQLLKVCLILWWYSDILSSFFVVVQYARYLWLFCVSYIIIPPTGCLGSTTLSTIPVIHLPSDIPGSSTFDAPYSGDIRAGITLVAIFSCLLVIRAKVLSPQSTSIACPPSTTRLQKLLVHNADDLINRTGSARTSRRQLRNDDDKDLFTVNNPELLQSKGVNSLAGFNRFSKLLDSLRSNDQNSSENQFSRSWKPSEPIELHQSLLQADLLLWRKRSRASLRRHNDIRNMAIREFHDTEKNFVESLEYLVQKYMRPLRQPLECILIDGALADKIFYMVPEILIHHQHFLAALNDRLEKFQSDTCFGDILLAHFRKQSMIETYMAFVDNFTLAKQAIIQARTKPSFEKYYMRCCRDHKNKIDLDSLLISPIQRIPRYELIIKQIVKHTSVEHCDYENLLLSQKHIHELAAAINRQKEDRDEREQRLREIEAIVDGLDDLVSTSRSFKRYDVVNIAGPSGWKQRCLFLMSDQVIVTSIKKKSPSGRNIRNIAQFLQSADFLEDNRFKLLVKISLDDIEIRKETLSLLRSTEVELQDTVEDESIINKMVELSKLLKTDYPDLSLLLSNIRTTTMQRNRALQEQLLSDPQLTTVEIEVTTISGVEKLTLHFPNADKRAIWENALIDAKNILRDSLEHDQTPIHLKSIITHRARSGLIFSAASPTIGRNADGAPNVWACTSDKFSGQIVIINVNGEPTIESNTSVGNATIVAICAVPAPRKKRRISAKKVDSTEVEQPGLELDSSSSDSEQDSDFEAIRKNVQSTIWIGNDDGEIFVFNFLENIRLKSRERMTRLALPVDDIVYLDEKVFVSSSSSSHTQLNYFQRAKDGIWDLENPKLVRIDLHMRLRPMIVVVSRLCVASGNSIYFINPTNTQIEKSCQLSSHAAESVGHMASLGSTIFVAMNKSAVIKVVNAFTLDIILEFTIANVVNKTLSYYEDIIRKHKMGCLRISALLSCKNRLWIGTSAGIILSTIVGNIKNNWTPSFHVCKAGHIGPCRFLTALSASSSSIMLTDMRRRRMSLNAPSLQQLDQIYIISGGEGFDNINTEISEEKTGIDDSVNHLLFWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6I7</accession>
    <name>A0A158Q6I7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3715</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000172">
        <property type="protein sequence ID" value="VDN53742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6I7"/>
    <dbReference type="STRING" id="318479.A0A158Q6I7"/>
    <dbReference type="WBParaSite" id="DME_0001020501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001020501-mRNA-1"/>
        <property type="gene ID" value="DME_0001020501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="31"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001020501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53071" checksum="76F1A583CC70F574" modified="2016-06-08" version="1">MEKELNLNYISYSNFPGSNLKIFFFQVNNLHWNLAVFICQLYCALDVAASSSSIIHLVLISIDRLIAATRPADYKATEHKRRIYFAIVIAWIFSTGISIPVGADFSSRMREFVINEHLCGIYSSKYIFYSSILSFYLPCCVMIVTYSYIFYVLRRRLRSVKLQHCQETFQEMAGGHFFGFGADLGNIATSAVQKATGVESENRKMISWEKPLLQKIEETKAEHASSLDDSDREHLETILDAATSDERSVTSVGSVVLDAITTVKEEPKIFYKIFARTDVKVFFHLIVFGKEQSNLIASSFALNNGVTSNFLSLLSPLQSHASKMRRLSDLIASWERSGRSSISEFSRMYTIARRESLYIARKKLAGMKDWALNLAAKLRMKQGISLRKEARATKLVAVVMLVFLCCWLPFFIMNMIKAYMLNFDFWPTYLEIWFHWFTALGYLNSSLNFFIYFAINEVFNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6L4</accession>
    <name>A0A158Q6L4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS10900</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001268">
        <property type="protein sequence ID" value="VDN60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6L4"/>
    <dbReference type="STRING" id="318479.A0A158Q6L4"/>
    <dbReference type="WBParaSite" id="DME_0001041501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001041501-mRNA-1"/>
        <property type="gene ID" value="DME_0001041501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN60927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001041501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28146" checksum="FC2AE5F08B155973" modified="2016-06-08" version="1">MIKAQKVGVKKNVGLIEFNRPKALNALCDQLMTELIQSLSEFDKDESIGAVVITGSERAFAAGADIKEMTEKDFAKVYYDSFLDRWCELTKVKKPVIAAVNGFALGGGCELAMMCDIIYAGDKAQFGQPEVNIGTIPGAGGTQRWARTAGKSMTMELCLTGNRISAKEAKECGLVSKIFPAEKLVEEAIKTAEKISEHSPLIVAMIKEAVNVAYETTLQEGLRFERRMFYTTFATNDRKEGMAAFVEKRSPKWTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6M5</accession>
    <name>A0A158Q6M5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTCK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001275">
        <property type="protein sequence ID" value="VDN60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6M5"/>
    <dbReference type="WBParaSite" id="DME_0001050501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001050501-mRNA-1"/>
        <property type="gene ID" value="DME_0001050501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="124"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="206"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001050501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28464" checksum="3EFFC77FEC0EFE37" modified="2016-06-08" version="1">MKAGRKCGNNMAYKIVDKVKYADGVSLEPLCILECTCLPVENQLERNETATPTLTQRSVTEQFSAHPTTQKAQRGVSRIKVERQKLMDVASQFLAEVPVSKACSGRNCVLGELITDSLCSLTDHKCGPNMVFKTLIGPMRVKAGLSSYKICFQQCTCYSSEYKKKGGQCIKKSSVPMRNETELSETRANCVGRSCEQIRNILCTLRGRKCGDNMVYKTIRRLVYIDDSPEICILQCICVSKKYVEKDGRCILRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7P7U4</accession>
    <name>A0A3P7P7U4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7P7U4"/>
    <dbReference type="STRING" id="318479.A0A3P7P7U4"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="2">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="1">
        <location>
            <begin position="294"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="418" mass="47629" checksum="CF2BA5DA60B84C7A" modified="2019-02-13" version="1">MFNENVNAFPFLRCDALKFVMLFRNHLPIEELIQVISAILATLSSSHIILHQYAAVALERILLVRLKNTDKLLFNCDNVVVGPLISSLFNCFSIYPKAQNSHYLMKAVMRCFNIIDNESAKHSNEIIDRMTNMIATAVKTPVDPLHIHYVFESLCILIRRAYLIVDGGIDKYVIPLIENILANDVIEFTPYSLQLTAVLLDEAYEQKKKTGTSLIDSYLPFFNYLMKEDLWNRTANIPAALLVIESFLQCSSENILANHSSMIQAIYQKLMGSKAQDHFGFQLAISLVPKVAVKSNIQVLESIQSGMFKMVIEKVITVELNEMSRILRFEEKRICCIGLINLTVETADYLGEYYAVMVEGLVKIAETSVYDASGIEDQCDEHELIEAYNDRYCKLVYAQHKFTLAVEIQNFKGYLHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PQB0</accession>
    <name>A0A3P7PQB0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PQB0"/>
    <dbReference type="STRING" id="318479.A0A3P7PQB0"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="351"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="457" mass="52372" checksum="052B8CECD6A1DA6E" modified="2019-02-13" version="1">MHYSKICCIFFLIAFYFKVITWRQMWIWLAEAEHELGLKQVTIEAIDEMKRSREIIDWPMIRAEEKRLKHDVMAHNYTFGEICPKARGIIHLGATSCFVQDNSDLIIQRQCIDVILNKLAICLDRLGDFADRTKEVVTVGRTHLQSASLVTVGKRAIIWAQELLMVLLKLERFYEEMRFRGIKGATGTQDSFLTLFHGEEDKVEKLDDLVTKKAGFTHRFSICGQTYSRQQDCDLINILALLGASLKKICMDLRFLQAVDELVEPFESEQIGSSAMPYKKNPMKSERICSLARRLISAPQDSLNTFGDQVLERTLDDSAIRRILIPESFLNVTEGLSLRKENINRNVMNELPFLMLEKALMWLTEIGIDRQHAHEKIREVALAAKEASKLAPISINSILSDVFFDPVRNRVIDAINQPLSFTGRCVSQTVRFLNDELRPAITKYLTAEATKKVDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PXU2</accession>
    <name>A0A3P7PXU2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PXU2"/>
    <dbReference type="STRING" id="318479.A0A3P7PXU2"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="113" mass="13119" checksum="1BFD1C9B21119699" modified="2019-02-13" version="1">MNFISIYLGAAKDTFHFLYTYAVLPVAVTALNIIRDSNERGEIYVAEPHVRDKLIPPSKSLEWRRWQEAVKFINLNESRVCTERRVINGVECSVWRWIPAKKTGWQGNGTSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q6K4</accession>
    <name>A0A3P7Q6K4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GT23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000014">
        <property type="protein sequence ID" value="VDN51161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q6K4"/>
    <dbReference type="STRING" id="318479.A0A3P7Q6K4"/>
    <dbReference type="OrthoDB" id="2014825at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11300">
        <property type="entry name" value="Fut8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11792">
        <property type="entry name" value="SH3_Fut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000070">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035653">
        <property type="entry name" value="Fut8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018074125" description="GT23 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GT23" evidence="8">
        <location>
            <begin position="55"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for donor substrate binding" evidence="5">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44523" checksum="81A89D20F403E525" modified="2019-02-13" version="1">MINKLKLQLFSLMGQSLAFGSIDNAGERRSMALREILDNFQEELSRLQNPANCSAARKLVCTLNKACGFGCQIHHATYCFIVSYATKRTMVFLNDGYSWRYSAEGWNYAFLFCKLLQDGDRESEWGSDQAKVMSLPIVDSLINPPPYLPLAIPKSISQLLLTFHSNPPVFFVSMFLHYLMRPTPYISKRIAEAAEKIPFDKGPIVGIQIRRTDKVGTEAAFHPLSEYMKWAEHWFKIEEYRAKKKFERRVFIATDDSTVFSEARKTLALFFMFFSLYVCNYLVCTFSSQVCRVGYELMQARFGDAGNNFHSLDDIYYYGGQQAHEQIAVEAHKAKTNDEIDLEVGDVIGIAGNHWNGYSKGTNRRTGSFGLYPSYKVREKWIIVAFPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QG53</accession>
    <name>A0A3P7QG53_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QG53"/>
    <dbReference type="STRING" id="318479.A0A3P7QG53"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121019" checksum="C31C2388BC55F9BA" modified="2019-02-13" version="1">MYLQESHLQEAIIAQQACTSGIAIENHVIPTPKVFLVGRLCYDSIYPVQPPPSNNHLIKVQASLTIEKDQPEYDIDSEDEIWLSDHRSSISINDFEKMMELLEGASSDLQICQPSEARALLKDFDDDLIDDVYDYWLQKRKDVAAQRNVASLIPKIKTDSRRDSLGSSNPYVAFRRRAEKMQTRKNRKNDEDSYEKIMKLGHDLCKALVIFNMIKKRLVQILFFSLTYFLREQAKTALVNLDEAVANARSSIDDMNGSYYNQIVAKLKAEQNLQNAAEKETDSSSLSEISKSTSSPVRSKNKKCRKYLNANLPKDDEIVSRAWLKRNIELWNRPPLVISGVGATCFQLPGSKVGVDRNAATSSDSAADGRYAFKRRRGCMYRESLPSWISRKYAHNRRTGSERALHNDLVEHTGSDRSRTSLSGIYKKSAKIVQDLSLNFYQTSLPLSIFGGIQRIGYARRRLGRGGRIIYDHVVDPCPSTSQCTADELLYADYAGILNNSRSYQPAVVETINDDMETSTDSDDNERVDPQSSSVIRSSLQNCFSHEKLPSSFEQKTRNDRIVQNQMYNQELRLTTDNDVQSSMLGTYRKANGFYANTRNSLSSVNGSLTSSVDSYQLVNNTETVLTTPANGQLVVTACSLTGGTVFQSPSSFVPIATSTHVIPSQQSGPQALSSSRRVNYLENRVLDSSMLTNRFPVTNPYGSSNQESVAYSLPRSSEAMYVSKNIETPQTPYNPAFRTTLPAHRSPVDAIAKRMEHVELSQQQQQSSMGPSQENVYICRPADRSLVNGAKRQKVSNCIPQLTISKVMDAKTNGDSLLTLGSYDTKRLELAIVGSGTRIKPPPSFASTLQQTTVLPSVSSSLANLPEKTPQLSHLLKVSVSKMRNGVTVPTFSTSRTTPGNVTEYHSSIISAPISSNSHFDINNAKTMQPIAVGDLDMPVTTISTIAKTASVVTHVTPIRSEAKLLNALPVNVISSPLTLTTTTPTTTVRCSYDCATTAVSKSSIQQYMVAAPVPRTTSMSAIQQRVNSDIRTCRKAAASAPLSVIEATSNNGGDNGGNNIHINNNEGLLNQYSKTNEDEKQCLADGYCYTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SGF3</accession>
    <name>A0A3P7SGF3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000114">
        <property type="protein sequence ID" value="VDN53242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SGF3"/>
    <dbReference type="STRING" id="318479.A0A3P7SGF3"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="125" mass="14807" checksum="EFFDDEBD335BDA81" modified="2019-02-13" version="1">MHFAFKGFHRYSSSSNYNQRNQSHKPNIWRNVCQNAKKFHSIPIILRSTNFDDSLRELAYEVTKQALETYVIENEVASHIKRRFDAYAGPPWHCIVGRNFGSHVEYDLYIHFSYDRFAIILFKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SHF5</accession>
    <name>A0A3P7SHF5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS4409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SHF5"/>
    <dbReference type="STRING" id="318479.A0A3P7SHF5"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="10">
        <location>
            <begin position="376"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN54436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="727" mass="84212" checksum="DBC11E2052FE59D7" modified="2019-02-13" version="1">MENVKRKMEENAKNCPSDSNISRVLFSNQLNKSNESTLCFNKAHFSRSDFNVERFINLARRRANLSQIHNDLRVYLKIVQNSMIELINDDYADFVNLSSSLVGLKDSIEKLNKDVESIWDDFFSSTSSLISAATNIEKYSIDLAECRQLQICIRSKISLIKAIERLSEILNNKPDELDGFWMSKLADSIVDLELWYKKVGSIDDKLLQLVEARSSCIVSVREIVEQWLIYDLEKDCQHINVLLGILILTDSLDSTVSKVMTEIIDCKIEKRRDDLERFLYSIFAEIKKMRKHFISKAKKNGNCNLDVTAFLDKCLLTYVMSILDQDRNPFILQYFGSVLIPSDNRLFHRCFLSTCEFISSWPNPASSRIVLRMIRDKFNLLVYFKLETQHILAELKESTIYEKINLIEHGSEIGNEKLYYQYSVIVINAFGRIWSDDVFLPPLIDKFWDFSIKLLSSYLGWLDKISRYSLAAVERNDDNIESWRLLCALRSDAATLDARIFDLALLTVWKKIREIEVVLIFWLNIFILTYKILDVTTFGQCLSFFSSRIAEKIEDLEKSSIEKVAKNLSKILEGVSDIPRHYRWTKKPFPAEASIYIIEAFSAFSDFQNEVGNRHWPSESIINVSRDILRVALIYFCKKAEQVLDSVEQTGSSLQRFKRRTTNLSDQSNTDTDENKIRNQLLFDLAYCLDWASNHSLELPVIVTLMERAKNVDVAIKEKVSAPAEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SQF2</accession>
    <name>A0A3P7SQF2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SQF2"/>
    <dbReference type="STRING" id="318479.A0A3P7SQF2"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="15"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="243" mass="28144" checksum="50A01C721E5421FA" modified="2019-02-13" version="1">MFWSYHFFLRSSRKVSGIPVIFVPGSSGSVEQIRSIGSILHNKTENRNSPFSFDVFGIDFNQELSGISGMYLERQIRFLRLAVDKIWNMYSPQPVGLIFVGHSMGGIIIRSLFYSHDFDLSRISLAITLATPHSAPPFVFDYYMERFYEKMRLEWKERAEQIKNITVISISGGLKDILVPEHLTQDSGIHHFSTTSIDTVEVEVDHLCIVWCNQLQRYFFILLNSILNLFIYLFILMNNNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SSB9</accession>
    <name>A0A3P7SSB9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SSB9"/>
    <dbReference type="OrthoDB" id="5877337at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="84" mass="9672" checksum="D22A4DEC112F386C" modified="2019-02-13" version="1">MTKHILKHHKKEQNAYIEGNISKKILKNTVLIFLKYTNGEIFFLQEIMDEENDKNRSFLLSLGLDSGSMDLRSNSPEEENSSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TBZ0</accession>
    <name>A0A3P7TBZ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS9292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TBZ0"/>
    <dbReference type="STRING" id="318479.A0A3P7TBZ0"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF10">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN59319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="392" mass="44230" checksum="1A4767F4D76AA7A3" modified="2019-02-13" version="1">MELLGGVPFVLTNVPQSLLSYSCLNPIYGTTINAYKCDRTAGGSSGGEGSLIACGGSIIGIGGDVGGSLRFPAHFNGITSLKRSGTSVMGRSLVDASLGPMTRTVRDAVTFLKIFWSERWFFRGDPYLPAIYWDDHQYLNKQPLRIGYYYQDGWFEPTPALKRAVQETHSRLEKLGHVLVEFEPPDMADAFKLFLGAILVDDGKYILDKFDKVLQEIFIFLVIITRIIFETRIFGKIVKPFWPRLSKVCEAFALNTSEMRQMFEDIAKYRHRFVREMKALRLDAIICPIQVVPAIEHFYPMKLISTVSYCGLFNLLDFPAGTVKVTEVSEIDELCLKDYPENDLWEKLVKKATKDSVGLPVGVQVASFPFHEETVLRLLAEIEKSVELEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0G1</accession>
    <name>A0A0N4U0G1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4399</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0G1"/>
    <dbReference type="STRING" id="318479.A0A0N4U0G1"/>
    <dbReference type="WBParaSite" id="DME_0000003901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000003901-mRNA-1"/>
        <property type="gene ID" value="DME_0000003901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000003901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35365" checksum="316B6B84607E9CEF" modified="2015-12-09" version="1">MYGTPTIRPNASFNANSDAETLRKAMKGIGCDKNKIILVLCGRTNVQRQQIASAFKTMYGKDLISDLKSELSGDFEDLILALMEPPAKYDALQMRKAMAGLGTKESVLIEIMCSRNNAQILDLRNIYRQIFNRELEADLISETSGHFKRLLVSLCAAGRDESMRTDPLKANQDARALYNAGERRLGTDESAFNAILASQNYAQLRLVFQEYQKIASHPIERAIEAEFSGDIKDGLLAIVTCIQNRPAYFSKLLYDSMAGLGTRDNDLIRVIVSRAEVDLADIRQEFEHIYKKSLESFIKGDCSGAYKDGLIALVRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0R5</accession>
    <name>A0A0N4U0R5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4514</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0R5"/>
    <dbReference type="STRING" id="318479.A0A0N4U0R5"/>
    <dbReference type="WBParaSite" id="DME_0000015401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000015401-mRNA-1"/>
        <property type="gene ID" value="DME_0000015401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001083">
        <property type="entry name" value="Probable splicing factor, arginine/serine-rich 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000015401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14999" checksum="300D966D6DDE841C" modified="2015-12-09" version="1">MSRRSDPLDCKVYVGSLPQDATSQEIEDAFNRFGRIRKVWVARRPPGFAFVEFEDSRDAEDAVKALDGTRICGVRARVEISHGRRRNTGFGGGGGGSGGGGGGGYYGGGGGGGLRRSRCVFRNYFVFNKAIFVLWVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0R6</accession>
    <name>A0A0N4U0R6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4515</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0R6"/>
    <dbReference type="STRING" id="318479.A0A0N4U0R6"/>
    <dbReference type="WBParaSite" id="DME_0000015501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000015501-mRNA-1"/>
        <property type="gene ID" value="DME_0000015501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF9">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079473" evidence="1">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000015501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30565" checksum="E877DC3164BB2DA4" modified="2015-12-09" version="1">MKFFLDSFHTVYLLLIVLVIDDSEQYSVNNTTFLENDAIVIDFKQLCEEGTPILQENNQLKLCYPYTTSNEYKCPNKFWCHIGTTNSTNYCCPETSNLCELHLTEGYGTSMLRRFYYDSNSASCKDFLYKGYGGNQNNYLSKTDCEQICQGYAKSTGISPSALFSGIHSEGHRTTIQENIFTKISSSQSNLVSPTIVPIQRATATAFLPNNYCELAPDKGYPQEGTQPSSRWYFDVSADRCIQFYYLGSNGNANNFLSEELCRQICNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1K3</accession>
    <name>A0A0N4U1K3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-dependent kinase 12</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cell division protein kinase 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS4851</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1K3"/>
    <dbReference type="STRING" id="318479.A0A0N4U1K3"/>
    <dbReference type="WBParaSite" id="DME_0000049101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000049101-mRNA-1"/>
        <property type="gene ID" value="DME_0000049101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000074">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="246"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN54878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000049101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="72873" checksum="7368D38EB959A565" modified="2016-06-08" version="2">MRMKQSLLGEIMTRHHDKRIDKNERKKKFKHRKRSLTPVKKRSRRRRSPSETSSSSSSSSSIRTPISSLRNSQVVPPPPPPPPLPVNIPAFVPPPPAPIGMDPASYQAAISAYTAQYGYGGQFPFGFTAPVIPPPPYSQPPLVPPPPVAPEPIIPPPPLPPMPAALPPPAPPINQPPPPAPQLSCSTTTSMNTLPPLPLPRVPQLTTPSVSASPSKRTFCRPLVLNKRLKLREDTENWGCSTVEKYEIKTQVGEGTYGKVYKAVDKYTKEVVALKKIRLEIEKEGFPITAIREIKILRQLHHKNIVRLIDIVTDKQTAADFRRDKGAFYLVFEYLDHDLMGILESHFVDFNDEQIASVIKQLLSGLEYCHSIGFLHRDIKCSNILLNNKGEIKLADFGLARLYDEELDRPYTNRVITLWYRPPELLLGEERYSTAIDVWSVGCILGELYTKKPLFQEYTEMEQLETIAKLCGTPSPENWPEVIRLPLYHTYRPRKTYPRIIKDTFAFISARPLDLLDKMLELDPRKRISSKNALIHSWLKDIDPSVIEPPKLPDWQDCHEMWSKKQRKSKSSMNSAVQVPAPPLVNQASHLSTQHSVVRSFISQQPSTSHNESISRPLLSSGYMKQTSSSSHDAKSQLCKRSGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U243</accession>
    <name>A0A0N4U243_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5078</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U243"/>
    <dbReference type="WBParaSite" id="DME_0000071801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000071801-mRNA-1"/>
        <property type="gene ID" value="DME_0000071801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5812690at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000071801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14177" checksum="A17FC9FC034460CB" modified="2015-12-09" version="1">MNFSLDTSDEKERMLRIILLIAIHQKAVVGAVISFETGSRQHSHSLCLSSTEVVFRSVKPFESALSRYARRESRFKCPSEITCLSELFYFMNTVDMSRFSAQILTFLPSFVILISMLSFKYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U296</accession>
    <name>A0A0N4U296_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5145</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U296"/>
    <dbReference type="STRING" id="318479.A0A0N4U296"/>
    <dbReference type="WBParaSite" id="DME_0000078501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000078501-mRNA-1"/>
        <property type="gene ID" value="DME_0000078501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000078501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="31459" checksum="A3B4E44CD9603B58" modified="2015-12-09" version="1">MADINELIKEEEAKYGPFFGTLGVSAAMMFTAAGSAYGTAKAGTGIASMSVNRPDLVMKAIVPVVMAGIVAIYGLVVAVIISGKVQPASKDYTVVSGFSQFAGGLVCGLCGLSAGYAIGIVGDVGVRALSLQPRFFVGMILILIFAEMSGSGPEIIEQVAYAPFFGYMGVASAQIFAVLGAAYGTAKSAVGIASMGVMRPELIMKSVIPVIMAGIIGIYGLVVAMVLKGKITPASQGYTIHQGFAHFAAGLTCGLCGLGAGYAIGIVGDAGVRGTAQQPRLFVGMILILIFSEVLGLYGMIVALLLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2C0</accession>
    <name>A0A0N4U2C0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5172</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2C0"/>
    <dbReference type="STRING" id="318479.A0A0N4U2C0"/>
    <dbReference type="WBParaSite" id="DME_0000081201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000081201-mRNA-1"/>
        <property type="gene ID" value="DME_0000081201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795265at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000081201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22277" checksum="1F06516F1B970AD3" modified="2015-12-09" version="1">MIFVSAEHGLVLSTSKGTDFNYFGSIITGNDTLGKNKTLLCSHSDGTILMHTTLGDLLRRLELDNNTSIGIGINSINLLLMSRDCIILVLYGNDNLITHTTSGKQLNYMKAPEKLLCGVLSRDGEYVIVGSEEGRVLVLRLFPLQLLYTFQQTDSSIRSIAITSNQRYVLAGLDSGAVIVFNIDFNKWHYEYRHRYTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2S8</accession>
    <name>A0A0N4U2S8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5364</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2S8"/>
    <dbReference type="STRING" id="318479.A0A0N4U2S8"/>
    <dbReference type="WBParaSite" id="DME_0000100401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000100401-mRNA-1"/>
        <property type="gene ID" value="DME_0000100401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="230"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000100401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55160" checksum="BE508C0033AAF85B" modified="2015-12-09" version="1">MALILCGVRAARNLHSPLLHNILRSPMLFFDTTPIGRILNRLGKDIDVIDQLLPLNFRYFMMCIKFFVPTSRQMKRLESIHRSPIYSHFGETIQGSVSIRAYNQVDRFCEISQDCVDTYIRVKYLNLISFRWLAVRLEFIGNCVILFTSLFAVLSQNWGMAITAGIAGLSISCSLNVTEALNFAVRQISELESNIVAVERVKEYAEVVTEAEWRIPNCIKEKGWPNYGSIEFHNYSTRYRPDLDLVIEKMNAKIYPAEKVGIVGRTGAGKSSLTLALFRMIEPTEGQILIDQLSITDLGLHDLRSNLTIIPQLKSHSLNKTLTNDVLQEPVLFSGTLRFNLDPFQEYEDNQIWQALHLSHLKSFTDGLTDGLNFTLTEGGENMSVGQRQLVCLARALLRKSKVLILDEATAAVDLLTDNLIQDTIRREFKSSTVVTIAHRLNTIMDYDRVMVLEKGRIKEFDAPQVLLSDHSSMFYAMALDAKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2X9</accession>
    <name>A0A0N4U2X9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein CASP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2X9"/>
    <dbReference type="WBParaSite" id="DME_0000106001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000106001-mRNA-1"/>
        <property type="gene ID" value="DME_0000106001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9895588at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000106001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24847" checksum="090AD231275A8A5C" modified="2015-12-09" version="1">MTFLIWGVASSNKIKQSKLIKELELRNKHLAIENEFLSASLAEENWKKLKEKEVNDLKVSLEAANTKNATLMSENDELMKKIAQLELKNEQQLKFPLECGTFITCYPSVPRVTGQDSDIVCNEEIGQINAESPTLKAMNAKYSTLEAKFSAAKEKWQEELAVSENELDKIRQEREVLVKTVRTLEEKLAKSEKRVSELKQLDEEEEDWTKISLGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3Q8</accession>
    <name>A0A0N4U3Q8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS5728</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3Q8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3Q8"/>
    <dbReference type="WBParaSite" id="DME_0000136801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000136801-mRNA-1"/>
        <property type="gene ID" value="DME_0000136801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 14" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="396"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="629"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN55755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000136801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="85663" checksum="DD3DCC7453FF594D" modified="2015-12-09" version="1">MKISARENDLFDLRDWKKLALFTKCAHCRCVGWKRSEHMNLLYCSDNKALNEISMKSTCKTCQHSLDFDSDFAEEHLDLVKKKKDREVRVLIQMACDTWDMHQRILGSENYEAIFHSFKFLMRKLGSTPKQIALSHLGSPPFEPLSIIKIVCNFLVVKNEGRRREIENEIDTASTFLRSINEWNLPVPKSSELSMKDLLNYRIIYARWMQFCSLPREYRSLQRYPVVKSFGRKFLILLLRYYIADLQQRSSFIDEQNAINFATDLNTMLATNDSICDPSVSYALPEGIRIPSPKRGRCLWNTLSGHHSETTSECSEGDDRCNKDSVKLIMMDEEVEGDISEDLMNRIIVRSEILAKKPKPFTHKMDSFELDVARSEASRQEEKDGIISFHVISNNMEANQNPEKIAWLLQLQGLFSTQLPRMPKEYITRLVFDYRHKSLVLVKQGRGVIGGICFRQFYTQDFIEIVFCAITANEQVKGYGTHMMNHLKDYHVGTCHIYHFLTYADEYAIGYFKKQGFSEKIAIEKKKYHGFIKDYEGATLMGCQLHPRVIYTNFALNAKKLNDLFESAVKECFSECGKKHAGIEHIFEQYRGSVVPCAAIPGMEHLSDEDSEPDQDMDHKIKTILQKLRADQAAWPFLKPVDSEEVPEYYDFIKYPMDLKTMTDRYKQKYYVHVRMLERMFIADLRRMLNNCFRFNAPQTLYYKAGCDLAKIANRLTKNAFPKSDIFPEAPEFLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U471</accession>
    <name>A0A0N4U471_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5927</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U471"/>
    <dbReference type="STRING" id="318479.A0A0N4U471"/>
    <dbReference type="WBParaSite" id="DME_0000156701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000156701-mRNA-1"/>
        <property type="gene ID" value="DME_0000156701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000156701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34507" checksum="213BE0760E1DE6FA" modified="2015-12-09" version="1">MAVSDCADEDIKHVVTNNVTEVDPLIQSTGTVSTGQKRQREDRGGPVSKKAHVDNNNNSEETVQVKMLIPSAAVGALIGKGGETMRNLKNESGCRLQMSKNQEVYHGTNERICLVKGKITSVMRVAGVVMEKIREKVDSSTPSDVYDHKGVERSKEVTPKSRVQMKLLVPNTSAGMVIGKSGTRIKEIRDQTGANIQVYPKAGSQEAKVSQERVITIAAESNEVLMNAIERVLEKVAADPQHATTIDFKENDSFGALHGHTAQGQTVQPFDFNSRPVGAAQFGGIQQSQFGQMNSAQVWQPSQQRALGEQPSYFLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U476</accession>
    <name>A0A0N4U476_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carnitine-acylcarnitine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS5932</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U476"/>
    <dbReference type="STRING" id="318479.A0A0N4U476"/>
    <dbReference type="WBParaSite" id="DME_0000157201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000157201-mRNA-1"/>
        <property type="gene ID" value="DME_0000157201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005289">
        <property type="term" value="F:high-affinity L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF61">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN55959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000157201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39285" checksum="1F316AABE5F902C7" modified="2015-12-09" version="1">RSIPSSGIAGVLAGHPLDTVKVQLQTQAPGQYTGTIHCFRSIIKNEGIAGLFKGISSPLATLSLTNAIIFGIYGHIVRQFEDQCSIKTHFIAGFTAGLAQSLISSPMELLKLHVQIQNDSLGVKKYRSPYDCLQKVVSQKGYKYLFRQYLYYFCTIRALFPCVFDCSFFLCHTFFFRGLLITQLRDAPSFGIYFASYEHIARLLSKDGNVESLTTSQLLFAGGLAGLSSWFFNYPTDVVKTTFQANSQHSSYAEAMKYIYKTYGIRGFFSGLNSTLLRAFPCNAATFFTVEWSHRLLQYINNALQNSNQQRLTLGPGQQTVYGLWETHYSFMAEAGCTFIDPMVHGNRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4M3</accession>
    <name>A0A0N4U4M3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aminopeptidase</fullName>
            <ecNumber evidence="15">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS6101</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="15"/>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4M3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4M3"/>
    <dbReference type="WBParaSite" id="DME_0000174101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000174101-mRNA-1"/>
        <property type="gene ID" value="DME_0000174101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="18">
        <location>
            <begin position="51"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="16">
        <location>
            <begin position="292"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="17">
        <location>
            <begin position="664"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN56128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000174101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="820" mass="95640" checksum="2F7EE3A60019A344" modified="2015-12-09" version="1">MTSCTPCHMQLVSLNYRLYDQSHERPTVVNNVDEISGPTIAELRIPADLSPLWYNLTIKIYLPGFVDFPNEKNLTFDGSICIKFQDEEMYHETSEKTIEKRSYNDSSNLEMYDGESINDVQEQMHFQVTTMYVDEAREKVTFELSEELIKGNNYYLQFNYSGSIEEKLVGLYLSRYTDDFGQNRFMAITQMEPARARYMVPCFDEPEFKAVWKLQIIHPSGTTAISNGMEIGSAVQMDDSNWLLSSFEESLPMSSYLLALAVTDFAYNEGTTNKGIRFRVWSRKEAINDSMFALESGIKALEFFEDYYQIAFPLKKQDMIAIPDFAARGMENWGLITYRESVLLYNPKAYTIYQKCQVAAIVAHELAHQWFGNLVTMKWWNDLWLNEGFATFMQYMGVDAINGKSFRMDEYFIYLSLTNALYRDAQSTSHPLLFSIDKPEDVSEVFDSITYEKGASIIHMIENILGAENFKKGLNIYLEKHKYGNTDHDDLWESLNNVVPEELKAWDGQKFNIHYFASMWTEQMGYPVVEVRRLDSETIQLHQNRFKWSETTLEKEKYRNAKYKYDIPIWYQINSEEKPMTWLHEAEIIGVKPHDLFIVNSQSRGFYRVNYDQAGWERIREQLMTDHTKIDVKSRGRIMADLFALAEANIVPYELALNISLYLKNIIGMYCAVRNLNCTQRLARLFEEKFLEQCADSDQMSSDCSRVPLSIRALAYCEGVKQGAEDVWNNVQKIYSREKIEVERQRLLQALCCSRDSFTLKKLLNLAVNVSDTTIRYQDTSRVFASVARESVGSLLMFNYLLDNWQCLYNELIRLLINRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U506</accession>
    <name>A0A0N4U506_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6263</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U506"/>
    <dbReference type="STRING" id="318479.A0A0N4U506"/>
    <dbReference type="WBParaSite" id="DME_0000190301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000190301-mRNA-1"/>
        <property type="gene ID" value="DME_0000190301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000190301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21870" checksum="988B7B5E85C7B967" modified="2015-12-09" version="1">MDNIVKFCQQPRLNLKNSPPFILDILPDTFQTLSTIIARDSNCLKENYYLQLFVENLHLKCKQTLKLFKEDRERIFDEGSSSRRNLTKLSLIFSHMLAELKAEFPDGIFIGENFRITKKEADAFWKESFGNKTTVHWLEFRAALNKVHKLNTGLETLALKSTIDLTMNEHISNFEFDVFTRFTSLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U555</accession>
    <name>A0A0N4U555_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vinculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6320</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U555"/>
    <dbReference type="STRING" id="318479.A0A0N4U555"/>
    <dbReference type="WBParaSite" id="DME_0000196001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000196001-mRNA-1"/>
        <property type="gene ID" value="DME_0000196001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29742at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000010">
        <property type="entry name" value="Vinculin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00664">
        <property type="entry name" value="VINCULIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="748"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000196001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="974" mass="108694" checksum="B01682358EB08002" modified="2015-12-09" version="1">MKFQVSRLVILHEEAEDGNAMPDLTRPVGAVSRAVDNLIKVGYDTCHSSDDRILQEDMPPALQRVETSSRLLEDACHMLKMDPYSGPARKKLIEGARGILQGTSALLLCFDESEVRKIIRGCRKVLDYLAVAEVIENMDDLAQFVKDISPWLTRVSKDIDAREKELTHQVHREILLRCMDTVKTLSPIMICAMKIFIQLTEHSQRGQYEASENRNYLAQRMVDEINEIIRVLQLTTYDEDEWESDNVTVMRKALSAAQSLLGAALDWLNDPRGRVGAIGEKAIRRIVAYSERIASRALPEDARMIRRTINDITSLADSLCEIRSQGGDNHGLAVNCSNKLKELVGTKEISGMLPSALINTQRTGGVHPAHTVAGQLEQAFRWLDNPGINDDGLGLQAIKAITNEAKKLCDILSPADRARMLDLCSDVDRLASQLLDLERRGLGNTPEADKLRYQLRNKLRELADFMKGVITDRVIEDFADISTPLKQFVDAVYAPPSMPNRERNFEDKAQNLDHHSSRCTQTALLVAKCGPCKNKKTVEAIIDTAHRVSAMTPQVINAGKIRLHNDTESANQHFENIHREYSDALNALRAHVDDAIDTGDFIRASEQAMRRYTNCCEDAIQGNEAQRMVDNTSQIARLGNRVLMTAKNEADNSEEPSFVQRVNHAAQQLHSAIPPMVNQAKQVALNPRHTGNAQNWRNANDHLLSAVRQVGDAITGSPHMNQTVLIESVPLKAPTSPVVHDHIYIREEIPAPPRPPPPIEISPPPRPPPPPETDDEEETRAFWERYPLPGASSQPILSAAHNLHQELRQWSSHENDIVAAAKRMAILMARLSQLVRGEGGTKKDLIDCAKAIADSSEEVTRLAVQLARQCTDIKMRMTLLQVCERIPTIATQLKILSTVKATMLGSQVTIGPYGQQIDGSEEDEEAMQQLVLNAQNLMQSVKDTVRAAEAASIKIRTNSGLRLRWIRKPMWSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U592</accession>
    <name>A0A0N4U592_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS6364</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U592"/>
    <dbReference type="STRING" id="318479.A0A0N4U592"/>
    <dbReference type="WBParaSite" id="DME_0000200401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000200401-mRNA-1"/>
        <property type="gene ID" value="DME_0000200401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000092">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF42">
        <property type="entry name" value="EARLY GROWTH RESPONSE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN56391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000200401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="61972" checksum="C102858F072B5CBD" modified="2015-12-09" version="1">MPAQADKFQASTVVEVKQSDHNLRNRIVNNKPVTLNGNMKPVGLSLNDNDSLKTPTILGNSEVALKTPTLLGSPTKGPLSTIGHCEELTTPKFSLNSYSSNNQTQAFFGEHEPLLTGPSGASTSAVNQNDTKDQKATITFKGSISTSISTFGTQNVNSPGLSASMFQFSPLVEHFLQSITKSQQTGTNLPLLVLDSNAKTPGATDTPDLFKVLRDKKDGIIPSSSSQTSSTLCSSGSQHVLTSEYQQVIFDLYNLVNRGGNIRRTPPPGPSGVNQNGFSGGAICSSLHYSHHHARGTCSSHPVNLSGTSTQAHNPKYHVGGRNMDESLASLELLITTLIQQNITCMVSPAEPCIQGAQSLAARPVPSSSQGSHYSTCSFSSSAPAQCSPSQTLRTQTPNASQGSSQTSFKTEFRPKLEPVDDYYQPSVAFEGYPEFENISSQSIEDHKNTSASSASAAGPSTSTKIRKYPTRLTKLPLHERPYKCPIEDCDRRFSRSDELTRHIRIHTGQKPFQCRICMRAFSRSDHLTTHVRTHTGEKPFSCEVCGRKFARSDERKRHTKVHAKQKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5L4</accession>
    <name>A0A0N4U5L4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6506</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Spirurina</taxon>
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            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DME_0000214601"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0042802">
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    </dbReference>
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        <property type="term" value="P:primary miRNA processing"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000214601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25836" checksum="FCE0D2BEDAB35FCA" modified="2015-12-09" version="1">MYNIKVNFFSEKIVLAYREPEHFDVLPEGWVEVTHTSGLPIYLHKDSRVCTFSRPYFIGPGSVRHHQVPVSAIPCLHQKRLIKEIEKNAAASANAVESLDAKALHEYASKIFRFKKIQVFQLLIIVSIISIKLIIFYFKFILALPSHVKLITVPSMETNMKPQHKGFFLNPHGKTSVGILHEYVQKVLKSTIDYVFSETRHVFSFSRLIFLFFLISIHSRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5M0</accession>
    <name>A0A0N4U5M0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6513</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5M0"/>
    <dbReference type="WBParaSite" id="DME_0000215301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000215301-mRNA-1"/>
        <property type="gene ID" value="DME_0000215301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000215301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18237" checksum="9814D5D1DB259574" modified="2015-12-09" version="1">MDYWINSSSLQKGLLERRKVVDDQTFLRTEESRPEAILIGIHCRLPNAKHKADKSGDEPLQLTRNAKIKHIFYRSTFEFRFRNFSEAAEISCQTCMNKELLFSCVPADRTPTKCQPFSELLFSCVPADRTPTKCQPKAALSSDILSILTIVLDEYKAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5T3</accession>
    <name>A0A0N4U5T3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6590</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5T3"/>
    <dbReference type="STRING" id="318479.A0A0N4U5T3"/>
    <dbReference type="WBParaSite" id="DME_0000223001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000223001-mRNA-1"/>
        <property type="gene ID" value="DME_0000223001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000223001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59753" checksum="DBAABBF8BDBEE809" modified="2015-12-09" version="1">MAKSAKESKKTVGDFNQLGWYTLFVCLLYEFLIISQVSNLIYMVFGGSVANVVSCGEYSFANMTSSEACDAYEKIKSTGCTPKLEGDFQSVNYEFHFFCGNAGKVKMSTSVQMLGIMFGAMTFGQLSDSIGRRKTLIFGSVGLIISGFLSTFAPNIIIFTILRFFVMLFTGGKHSVSYVYMMESLPTKHRMWLVTVITYSPNYVVFTALAYFTGSWRLLSRVIAGLTFLPLIFLLFIQETPRWLVQKEKIDEAREALVTIAKWNGKNTAEHRKAIDDVLNQERERIRQAAGRPKKKYYTYHLFMYRDYAIYTILFSFSLVTTSIITYGLMFNFEKLSGSPFLNTIIIGSLRYTINLVVALIDIKFARVGRRLLHGCAMSFMAFGLGLVFIIMAFDLRMQSVIRMAALSVSAMGSQIYILNAIAPSELFPTAIRNVGMGFVQTFNRIGNVIAPQIFLLGSFWAPLPYFVMALMSLVEVIAYLALIPETKGKPLPDHMPDEGITDAEKQIEQEEDEVSEIPEKKPPFDDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5U4</accession>
    <name>A0A0N4U5U4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5U4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5U4"/>
    <dbReference type="WBParaSite" id="DME_0000224501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000224501-mRNA-1"/>
        <property type="gene ID" value="DME_0000224501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000224501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43592" checksum="FF0A6A966129E0FB" modified="2015-12-09" version="1">MNDTCNLKDEIVDRLRKNGTLDRIQAELRSAIYLAIENDTNDICVREIDANKTAAFSIIYHYLRENRLLATAAVFEKECREVGPIVILNPEKLRNNATFFIKTDANERMELNSIRRQKTIEPHARNSSMEKTDEKSIKSAFDRTRDGTVETPSSASYSTRIPDPAPEIKKTSINDKETQNDPLISKNDTTVNVERKPFQEKDILKKTTKYDEFLVHKEEPTIEESKQTLKNEEKTKTLESKENKADFDWKLEAYTPKFPNSRITQMYSKLKNSQVPTNKTSSDSETSSFESSMTKTPPSKATPSKIVLPRKLPLLREANPSTTTNLPTITAKDSLASKSSTQLSKKFDAILHQSSTEEKDVEEDIAIEELIEPNDDDDKSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5Y4</accession>
    <name>A0A0N4U5Y4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS6653</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5Y4"/>
    <dbReference type="STRING" id="318479.A0A0N4U5Y4"/>
    <dbReference type="WBParaSite" id="DME_0000229301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000229301-mRNA-1"/>
        <property type="gene ID" value="DME_0000229301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000008">
        <property type="entry name" value="smad nuclear-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN56680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000229301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="47776" checksum="9B1CFCDAD6E36740" modified="2015-12-09" version="1">MKKDKRKHANHYSSDVDDVKIRRKKSHKKLKSSIDSEKRVMKQRDRSYSPRSRSNSEEDLIPHKNSSNIRRERYSGSRRERKIYGQRNDDIENKRYHDFDDGDDDDDSGSVRKKNCADKYSDFRKDKKESYRLEKNTYRGEKYKSNASRSKDKHDSSASSSQFGLRKSSFVGKLFYFIFFSVYFLQAKFNTIQYEIFIERNCEITKKNFIFSEIKWGKKELWENSGTVEKAPIEKEKPNFVPSGKLLEDTNMYKGVVIKYNEPPDARKSKIRWRLYPFKGDEALPVLYVHRQSAYLIGRDRKIADLPVDHPSCSKQHAVLQYRLVSDERSDGTVVKRIKPYIIDLASVNGTYLNGERIEPQRYYELREKDLIKFGYSTREFVLLNEKSCQEEEPKEEIKKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U604</accession>
    <name>A0A0N4U604_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Decaprenyl-diphosphate synthase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6678</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U604"/>
    <dbReference type="STRING" id="318479.A0A0N4U604"/>
    <dbReference type="WBParaSite" id="DME_0000231801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000231801-mRNA-1"/>
        <property type="gene ID" value="DME_0000231801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000231801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42435" checksum="4BA521892E5FB410" modified="2015-12-09" version="1">MVSRLFLRSSTATGISFTTFQLIGTFIQNQFRKFQLDIMESAMISLVIPTSESSTSFSRNMEEMAKYYFNIGGKLFRPTVSLLMARACNQAFYFIFCSISRKVLKILQNMPTVELGRETVTLNQYRIALISEMIHTASLVHDDVIDKADMRRGKPTVNALWGNKMAVLVGDFILARATQVLCSIGRSNVISVMSTIIEDLVRGEFMQMIGNDELDAAKRFDKYMAANYSKTASLFANSCKSVAILADVQESISLAAFNYGRSLGLAFQLVDDLLDFISTPDTAGKQTAADLKSGIATAPILFAAEEYPQLNLFISRQFSEQNDVNQAREIVGNSYGLQKTRKLAQNYAYDAIKAINEFPNNDGIRDYLVQLALNQIERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6L3</accession>
    <name>A0A0N4U6L3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6931</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6L3"/>
    <dbReference type="STRING" id="318479.A0A0N4U6L3"/>
    <dbReference type="WBParaSite" id="DME_0000257101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000257101-mRNA-1"/>
        <property type="gene ID" value="DME_0000257101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859844at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14510" checksum="D6640FA3D0C1A792" modified="2015-12-09" version="1">MLRAMVPVTLCRSATFIDTPIRESVENLGGSYIAEPQTYIRRYATQTPAYTVAYENYVNPSYVHYSNAKQHDSSDKALKFARELRDQGLTRTQRIANAFQESHIRSTVPPQTIESVYRVCVRILCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Y3</accession>
    <name>A0A0N4U6Y3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc_ribbon_16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7077</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Y3"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Y3"/>
    <dbReference type="WBParaSite" id="DME_0000271701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000271701-mRNA-1"/>
        <property type="gene ID" value="DME_0000271701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="5">
        <location>
            <begin position="367"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="4">
        <location>
            <begin position="761"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000271701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="900" mass="102495" checksum="A2B9A570A51565C9" modified="2016-06-08" version="2">MNRNVRWLHGEGDRFFVISAERFGVFSAESDFSPKLVDEIPLNNQSKSDQDRLRCFDLSILNNDNLALGYQNGKILVSKLAIDPDIRTLKNSLELNVDVSKPVSFLRFSPIASNYLAACFEGGRTVDYSLFIYDLNRIQFHPFRLNTADRINCSTWFSDDLNMLVVGCNRTLKLFDIREGTHQTYTKSMSSCIRALSSDSFNNYRFACMADDALHILDRRRLSSTHKIPLPDRKKNDSTNVELSWNPTTPNHLTFLRHCARSITDVLVFSDKVDNLGKEESRAPKLFGLSRISGFNWHPVDKYRLLLTGPEEASKSYSVRIVRVKPFVCVSSSPQGYIASSVNNELRLHEITPILENYHIVDIGSVMHQRAIDYYGCSGHLTLGSYIGSCKEVIDDCPFASSDLKWVWKWLFSMLNIVDWKYDVYGTWFPGILQIMQKDTSNSIVSERISVSDLLLGPMRIYRSKERSRILRYCEWPSYGNQSQLDAFVDENFAHRATESRAVAAALFFGNSLRMKNLLNTMIEKYRIANDNSLVEVEIFYEAIVQYKGIIDHWRSVSEGLRRTIRNPYFKMILTFLTGYCDSSLDLTMILHQEDIPLEDRIAFGALHLNDQLFVKGILSMFNETDLHMKLQGLFIVGLTRDIDTHILLGKYVDNTGDVQTASIMVIIGKCLESTSSDHLDGMEASINDTDLRTTIVDQAHFSQKHIIRTSSIICEYREMLNNWSLWIQRGRIDGLLLWQRNMEGKLPLASACSSEVEICCPFCRKGITVEKYDASSDLPRDTSKNLKTAGSPQLSSAKFRNTRELACQNCLKPLPKCVLCRGYMGSTVAAECADLGRSSSWFSWCQVCRHGGHISHLRHWFRSRSECPATGCMCKCQDIDTNISGSSSGRDWYCNCDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7I6</accession>
    <name>A0A0N4U7I6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS178</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7I6"/>
    <dbReference type="STRING" id="318479.A0A0N4U7I6"/>
    <dbReference type="WBParaSite" id="DME_0000294901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000294901-mRNA-1"/>
        <property type="gene ID" value="DME_0000294901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000209">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF77">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="226"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN50205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000294901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="508" mass="56283" checksum="E1CEC7BD4CD00169" modified="2015-12-09" version="1">MFGLIVTANAIREWFSKSKEIYQLESVMAEFQLSNDTLRRMMAKMSADMDAGLAGGIEKSTLAMLPSFVPELPNGTEEGKFLAMDLGGTNLRVMVMDIKPGHEPVTEQFNSRIPNWAMHGTGEQLFDFIVKCLADFLIERGIDQSNLPLGFTFSYPCDQRSLCYARLIRWTKGFNVSGVLNEDVVALLEKSIEKHGGIKVRVVALINDTVGTIVAAAYEAGSECHIGAIIGTGTNASYIEDTSKIKYGLSKSLTPYPYKQMIIDIEWGGFADNHEADYILTQYDRIVDSRAEHPNVNTFDKLVAGKCMGELVRVVLEKLVRCGVLFKGKESDVLFTPDTFPTKYISEILNDEGGSYANTRQIMDELAIDEYSFSDMLLLREVCCVVSRRSANLAAAAIACALNRIRKPNMIVGIDGSTYKYHPFFDLWVTDKIKELIDPSLKFKVIQTGDGSGKGAALIAAVISRLEKAKKASNDIKLNQKLEESNQNDEVTGSHIRLNVSNFHDKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7Q5</accession>
    <name>A0A0N4U7Q5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS7186</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7Q5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7Q5"/>
    <dbReference type="WBParaSite" id="DME_0000302701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000302701-mRNA-1"/>
        <property type="gene ID" value="DME_0000302701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876933at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN57213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000302701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="29501" checksum="EAADA7F42BE774AD" modified="2015-12-09" version="1">MTMNMKVIVYSAIGISIFAVLTTVVTIGIAFQNMNALCEYVMDEMGDFKKVADDTWNKILYIKSGPLKRYQIQEKLHGIIERHHREANKCHCKPKRKKCTPGPPGPPGNTGKPGADGVDGEDGKPGAPGVALLATYHFPSGCIECPAGPPGLKGPRGRIGEIGPPGKVGPVGNKGKEGKAGPTGKQGMTGKVGHAGPPGRPGVPGLDGKKGRGRPGPKGAPGPLGLPGPKGFDGKPGLVGEKGRQGQPGRRGKDGIPGKNGRQGKMGAKGIPGPDAYYCPCPSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U856</accession>
    <name>A0A0N4U856_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7363</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U856"/>
    <dbReference type="STRING" id="318479.A0A0N4U856"/>
    <dbReference type="WBParaSite" id="DME_0000320401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000320401-mRNA-1"/>
        <property type="gene ID" value="DME_0000320401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000320401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22376" checksum="6D6EB1B0E5EB7108" modified="2015-12-09" version="1">MTTPSRRRLMRDFKKLQEDPPAGVSGAPTEDNILMWEAIIFGPHDTPFEDGTFKLTLEFTEEYPNKPPTVKFVSKMFHPNVYADGSICLDILQNRWSPTYDVAAILTSIQSLLDEPNPNSPANSLAAQLYQENRREYEKRVQQVVEQSWLNFGENEGELEAKESLDTNEDNDNETGRDESQMPSASGVSGSSASGSQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8H7</accession>
    <name>A0A0N4U8H7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8H7"/>
    <dbReference type="STRING" id="318479.A0A0N4U8H7"/>
    <dbReference type="WBParaSite" id="DME_0000334901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000334901-mRNA-1"/>
        <property type="gene ID" value="DME_0000334901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="88"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="316"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="576"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="777"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000334901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137538" checksum="5F607432599534E1" modified="2016-06-08" version="2">MVHTNQSLALSSLPSGWLYGKTNCSTIHKICERAKLLNNRTNILIKIIVDSLQTLSPQITSLIQLAENVIDSSFATANQTVVANCDIDLVFVIDTSQSVEDEFAMQLQFATDLVKAISPSDLGSRIRIAAISFYTQTATEFNLDQSNSRQEVLDALSAIKHTGGGTSIASGVNLAVHEFETRGKIHARRMVVLISDGNSQDTWDKLLIAANRLRSINANVYVVTASSDYFFRELEIYAGSKWFVFTDARKRQFLGEAKKFIGQCENQIYSTTKIQRSTVSPIINTTFDLEIEEPTSSTLLPLTTSSAIVCKNELVDIAIVIDTSTSVDKEFDAEKSFALDLIKILPETGFIEQFAIAIIQFAGNAKLTFGFGQIPKRDDILYEIDRIENSGGQTSLVAGINEILKEIERRHRPNARLITVIISDGNSQDSWPVVQKTAGKLRDISEVYAVTLSPSYYYDELKEYTGSDKRVYVDDRISQFLKEVGISVLSCTGQQRRANAASDQIYTIFNNEFDLNNIDVKYKKLRAKIIAARFENVTLKDHTSSKRAEFAIDEIPTVKVYNSETNVQKCNYSKMDLEIILDASSSRQEVFEHQRELALSLIERLPIDADETHVAVGINSFTQVPTLRQTLGLGRDKQMVRNVIENIKYKGGSTLTARAVQLSVQDLQRGRRPDAIQVVVLMNDGMSQDPWDAVLLASDQLRATGAERFGVALGENIDLRELKLYIGNEDRIYRDGSTERFLSDVVNLLTAGKNCSFSLTQKPTETNISNCKPENLDIIILFDNADETDNLSDPAITANRYLLLDILGSLPVETGARIRFSINTFTNEPKSIISLSDRQERQLIFNKVETIKAEHGKSSYARVVNHALNEYEKSHRTDARGILLIVGDGKSEDDENSRKSASQRIKAAKGLTCFAVDGRKSIDSSVLAEYTGSEERVFNYDKNAEFARIFLQETSAPTNSNCSTYFLEQDKSLVLKSIKNIQNSLVDDLRNTTLSREVSIKQGRLSPKSSKAISELLATTTIPPRISATSLNSKLPMSFEFSNASEPSAIEMVAPGCKIDLIIILDSSGSVEDSFDREKQLASGIVERLTVGPNDSRIAIIKFAAKEKVRTIWSFKQIQSQTSIRNALKSMTFSSGTTAIDTALLQAIAEYTPGKGARPGQATPVCIIFTDGFGQKDATESANLLRSIIPNVFSVAVTRQMTVNRHELEKIAGSKQRVFTDDNILQFYAVFEKLRKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9C5</accession>
    <name>A0A0N4U9C5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7682</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9C5"/>
    <dbReference type="STRING" id="318479.A0A0N4U9C5"/>
    <dbReference type="WBParaSite" id="DME_0000367701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000367701-mRNA-1"/>
        <property type="gene ID" value="DME_0000367701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864419at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000367701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49077" checksum="B19835EF98C72167" modified="2015-12-09" version="1">FSRFLEDFIPEKWLGRGGYGIVFKCRNRLDDRSYAIKRIAVSNTLVLILLSFIRICNHFTKEPKPICCYSKKLYKGNSNARNIAMITCNMGTSESGSWAVGSEDSNITSSSQSNHSYNENAEPALPATAKEESFGIIFTNNLNGENHSVAESESNSSTSNEHLFEPPAVLVAGKKDLQKCIRNKNYSYLYIQMELCQELTLHNWLMANNKEEDRVIHQMRNWLAQLVCAIDYIHKQGLIHRDLKPQNIFFSASDFATLKIGDLGLAINYLNTGEYDATKEAERHKHTSNVGTRLYMSPEQLRGRSYNEKVDVFSLGLIYTEMIIPFKTSMERYNTLFDLQKGKSPKSLLKISDSEVNSLFLLFFSLKNISEIEIQDFIGWLTTLDVNKRPSCYEIMNSEYVRPDIQLLGSAFDHNRSRSCSDSRISFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9J1</accession>
    <name>A0A0N4U9J1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7766</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9J1"/>
    <dbReference type="STRING" id="318479.A0A0N4U9J1"/>
    <dbReference type="WBParaSite" id="DME_0000376101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000376101-mRNA-1"/>
        <property type="gene ID" value="DME_0000376101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416987at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000376101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29110" checksum="E5A4D8FCC69BFE0D" modified="2015-12-09" version="1">MAYATTIYTYREGMRKREPFLVYAKSHIVPIKGMTIARLKLLAVLIGVQTGRFVLNQLDLEENRVEEIRKAKLNFRYIPRNEKPVDVATRRLSPTNLKNSWWYGPSWLKKKECEQPQCEFQAKSTKSMKKWKTQWADVIIDTTNAQHSDSSNAKQKNKFEWLNPISDEFSYITMKKVDTARRIRQAQFDGLVNIKLEYGSGKRWIALFTCNQNDASRNSRESAETFLLIFRRFISRRGCPKLILSDSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9T8</accession>
    <name>A0A0N4U9T8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7876</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9T8"/>
    <dbReference type="WBParaSite" id="DME_0000387101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000387101-mRNA-1"/>
        <property type="gene ID" value="DME_0000387101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000387101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23644" checksum="6343892C31E30D90" modified="2015-12-09" version="1">MDISVSCDAIVTSFKAPASIRYYRGQKKKFIYFIALLLMSRRASLPFTPAPTENLPSDNDSMVPQFHHYYSSHPQLPQINGISRSLFPYYSFERKSSPLAQSILSKRHPANRAFIGLQWTPSSPTLNNCGFYPIAQRFISLPVRCSYVTNRYYHDNPQILPPKKYNFRRSAKSDLAHRFQKNSDYSNESTPSRGEIFLYKYLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA04</accession>
    <name>A0A0N4UA04_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein tweety homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7955</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA04"/>
    <dbReference type="STRING" id="318479.A0A0N4UA04"/>
    <dbReference type="WBParaSite" id="DME_0000395001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000395001-mRNA-1"/>
        <property type="gene ID" value="DME_0000395001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5838962at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042799" evidence="2">
        <location>
            <begin position="16"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000395001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23148" checksum="5DD885C24D4D5D12" modified="2015-12-09" version="1">MLILLLNCFIVYCLAQNFEIGDNATIKGCSSHCSMHDIDLSCWNQTLNFYEQILFSQMKFYIAVQINIDRWHRRRFPKYVSNFSQIKLDTIHNLNSLVAKGGIIDNNTIVTVVNALVDQVQKNSRTVESHKTHIACPLPCEYKSKLWRYLFIASCALNILLAILGLQITSVRWVTALICHFVCIIANVLYGNSRGFIELRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAF2</accession>
    <name>A0A0N4UAF2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAP10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8008</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAF2"/>
    <dbReference type="WBParaSite" id="DME_0000412501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000412501-mRNA-1"/>
        <property type="gene ID" value="DME_0000412501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF122">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="205"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000412501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="446" mass="52206" checksum="4900908937096B47" modified="2015-12-09" version="1">MKFLVINNSICFGSLNFDLPLRYLHIQLVNQENSINLTHSIGRLNVFITNERCRFKIQLIDNFDGSYVLRIRLWESCPQLTISIQSPNGDFLCNSPFIIKKTNGNDLYPEECDCPEYNLTEWISEANCSPQMQLITDLNQWNIIDFDNMIDIAEKSWGSVEQKHTAAFCHYQIIDNELYRHCYGEHTGFRIFTDSILTSLMRKMFLPNTQFFFNLGDWPLQEKQKSNTVAFVSWCGSEDTMDIVVPTYELMNSVIDSMHSVTLDIHTARGDIHIPWTEKKNTAIFRGRDSNKLRLEIARLSNHKFVLCVDGTVAAYRFPFLLAGDSVIIKSNSHYYEYFYSMLEPNLHYIPFNKSSDLSFIIESARKQDFNKTIANMRQFVFDHLQPRDLYCYYANFIHEYTKKLKDLPTNIAKNMENISRTPNKKACRCHKIKQKTHKTNKQDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAF9</accession>
    <name>A0A0N4UAF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8016</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAF9"/>
    <dbReference type="WBParaSite" id="DME_0000413301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000413301-mRNA-1"/>
        <property type="gene ID" value="DME_0000413301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000413301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15666" checksum="D3EB10C273B546DD" modified="2015-12-09" version="1">MKELSETTDSDNQLCVQKLTLNVPRNSLNEQQFSPIHINRETEIFHETTWKKEQKHSETPETFARVLSREMLAVTAYGTLERLWISQTKRSLSMFFLNKYHVNVACRVYMAWMCMFHRADSRVIESGSEQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAX0</accession>
    <name>A0A0N4UAX0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8206</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAX0"/>
    <dbReference type="STRING" id="318479.A0A0N4UAX0"/>
    <dbReference type="WBParaSite" id="DME_0000432301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000432301-mRNA-1"/>
        <property type="gene ID" value="DME_0000432301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10620132at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000432301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="76206" checksum="4ACABBEC0285FE2A" modified="2015-12-09" version="1">MDSDPNSPRHSVPYEPSSSVSNWSTNQDISTNRPSMRSNHTIVNSFDNSANLSRIINYPPKRKSYICQPKYRPYNANRYYQNLQYANIQLQTDLSDRRYQCNNSNNTFRCNSVDDRCNIFEIGRHLIEGNYVSSDGIEDSGAELVVDPVRIDIESLIENLFEQEANSVDLIHAFVGMAAIVSRKGHPYCLLLSGISEQIWCVVFWMGKISFGISASVINCLATTNERLTEEINKLRRRFDVTSNFMPKEQIYNLPQFNQLVYNPARASTKKFPIPSIAGISARENLGIYLVELSGDGEFIQRKSVLVRIQKVSRYITYRLYGCFSVRSRDRSDAYQDFPQVILKALADLHLVCCGLSLGTGDDDSIYRIINVSDCAVKTALNDLRRKPPKMSAKARIRNEKEYGVNNLVEIMSKSVDSFVPEYDRSLNHVFFSSIPAASSSDTKGTNERQSFFSVYKTFVENRLSLIDSLRNIADEASKIHDNCKVATITGSSIGLVAGTAALIGSIAFPPLFLGGIATTVLTSVSNIGTTITEFIIIKILLEKAMKLSVYDLELSENLEKAFKNIISSDTIEFKKDTDLSDPQNLTAVGLHLGLGTVKGAATLGIRTVGLKTVSMSEAVLRGAARGAVGIGIVIDGVTIAITASSLAKGETSKLSEELRKIADIKSEELVMIRNRIRGASLINFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB98</accession>
    <name>A0A0N4UB98_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COP9 signalosome complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS8348</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB98"/>
    <dbReference type="STRING" id="318479.A0A0N4UB98"/>
    <dbReference type="WBParaSite" id="DME_0000446501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000446501-mRNA-1"/>
        <property type="gene ID" value="DME_0000446501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="264"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN58375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000446501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52243" checksum="BEECFF74C0B39238" modified="2015-12-09" version="1">MDDDYMDDQDYNLEYSDDSDSEPDVDLENQYYNAKALKQEKDYDGALQGFHKVLDLEVGKGEWGFKALKQMIKITFALNSYEAMLDYYHQLLTYIKSAVTKNYSEKSINSILDYISTSKQMDLLQVFYETTLNALKCSEGMEIKFKDAKNERLWFKTNSKLGKLYFDRKEFGKLEKIIKQLRQSCKIKLQNEVGEDDQKKGTQLLEIYALEIQMYTEQKNNKALKAVYEQSLRVKSAIPHPLIMGVIRECGGKMHLREGHFDEAHTDFFEAFKNYDESGSERRSNCLKYLVLSTMLVKSVINPFDSQEAKPFRNDPEIVAMNRLVSAYQNSDIHEFEEILESNRESIMADPFIREHIEELLANIRSKVLLSLTKPFTRVRLSYLAQKLHINIDELVKLLVELILDGTLNCKIDEINGILIANSADDERYEALEACVQNLQMLGISIVDRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBC0</accession>
    <name>A0A0N4UBC0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8373</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBC0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBC0"/>
    <dbReference type="WBParaSite" id="DME_0000449001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000449001-mRNA-1"/>
        <property type="gene ID" value="DME_0000449001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="116"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000449001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36616" checksum="FA7659EE73736A67" modified="2015-12-09" version="1">SWKNACGCEPYSIKSQECHSLLKKYLTKEIVEQLKTQKTKLGATLLDVIQSGVENLDSGVGVYAPDAESYTLFKPLFDPIIEDYHNGFTVNQKQPNTDLGEGKTQLLTDLDPEGKFINSTRIRCGRSLQGYPFNPCLTEANYIEMEEKIKKIFEELVDDDLKGHYYPLTGMTKEVQKQLIQDHFLFKEGDRFLQAANACRYWPKGRGIFHNNKKTFLVWVNEEDHLRIISMQNGGNVGQKSNLGTTVRASVHIRLPKISAKPDFKNICDSLKLQIRGIHGEHSDSVGGVYDISNKARLGLTEFEAVKQMYDGIKHLIELEKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBP3</accession>
    <name>A0A0N4UBP3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8519</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBP3"/>
    <dbReference type="STRING" id="318479.A0A0N4UBP3"/>
    <dbReference type="WBParaSite" id="DME_0000463601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000463601-mRNA-1"/>
        <property type="gene ID" value="DME_0000463601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF23">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000463601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20290" checksum="52F9C52342B9388E" modified="2015-12-09" version="1">MSGFGEDINWVSWEDAIETALEKDKPIFLLIHKSWCHACKALKKSFQQSNARKAFKKLSEYFVMVNAEDDEEPFEEEYRPDGKYIPRILFLDKNGDLLPEFKNKKAEYKNYGYYYSSPADILNSMKDVLKFYNIEVPEMKKGEKLKVRKSEEKENMKVEDEVKSDSKEKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBU5</accession>
    <name>A0A0N4UBU5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8582</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBU5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBU5"/>
    <dbReference type="WBParaSite" id="DME_0000469901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000469901-mRNA-1"/>
        <property type="gene ID" value="DME_0000469901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBA" evidence="1">
        <location>
            <begin position="101"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000469901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36537" checksum="F008711B626D8DE0" modified="2015-12-09" version="1">MMGLADSSDKGRSYAEEIWNNLPLDALSEIFLRINCLKTVACSCPLKKRFLQVCRIILQVCRKWCTILSSNVFWIQYGQRYLIAVPPPKLRNEPCLNMKEICCFEPFERNLLLNDSGQNDFDHWVIVSNYGDGFVIEKPPICCLNDDNGDQIETAFVTSYGWCRMFQCVDLWKKGIKPEFLDKFRPPITVSEIFNCRRDCAAIYALQVHLKKCFGKTQNWEDYKRSPSFLNLPNPIADKTTNMYISRVRRMDQWSEAKWQKIEHTFEDYPKGIRYVIFDHWGKDEQFWAGNYGAKMARATVIVHFGDGIPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBV2</accession>
    <name>A0A0N4UBV2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome endopeptidase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8590</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBV2"/>
    <dbReference type="STRING" id="318479.A0A0N4UBV2"/>
    <dbReference type="WBParaSite" id="DME_0000470701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000470701-mRNA-1"/>
        <property type="gene ID" value="DME_0000470701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000470701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24459" checksum="2E8082F74E1210EC" modified="2015-12-09" version="1">MSRGSSAGFDRHITIFSPEGRVYQVAVKGSESVVVAVQKRVPDKLIVAESITSIYDLSPTIGAAVIGLIPDCKFQVKRARAESAEWKYKNGCDMAVGDLSRRMADLNQYYTQNAELRSLGCVMLLFSYDEEVGPQIFRIDPAGYYRSMRGVGVGVKQQAVNTFLEKKLKKKTGFNLEENIQLALECLQTSLGVDLKSNEVEVAVVTKDNRKLRLFFEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ9</accession>
    <name>A0A0N4UBZ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">F-box only protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8645</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ9"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ9"/>
    <dbReference type="WBParaSite" id="DME_0000476201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000476201-mRNA-1"/>
        <property type="gene ID" value="DME_0000476201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000476201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="497" mass="59113" checksum="E2F626AA8AC31125" modified="2015-12-09" version="1">MMKSLIPLKLYLFHSYLMRIFSEFAIFSRTIYFAEIMDASLEIDDHLHCIYCYRIDCNYNKCFIICCPECSVRLHACKLEDHFLICPKVLVYCPNSTYGCRKRIFRDKIATHLHRCCASVVVCAIQWNRKVVSSYAKRKMKRFAKGLDKFSDRIRIDASEIDICETVRDQEVLLDSYRTSRQDRKRLTDYHNPCHPPLPLRIALQKQETFIDEDSSDDENRAKALQLKKKKSPFENCYICKTDPSSQHLHTLGNYIQSEKDNLDAILPQIQITSIPRFYLERRIFVNIIRERISMFVKKDENLPFVRKGIAVYTFICNDCYRRDEYSNHYKFSHMENDEFIGRCPSFPSGCPFYYHKKKPKWGSLRYNSYTSSVVHCGSEVENVHEEPNATIYSMCEMPFDVLYAIVDYLDSGSLRCLSAVNRQMRKFCFIYFNHLAMVHIKWMKSDTNHWFRKCFVSFTFLYIINHRQRYHHFTNYFMQFQLTGFCQLVRAGHCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC30</accession>
    <name>A0A0N4UC30_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8683</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC30"/>
    <dbReference type="STRING" id="318479.A0A0N4UC30"/>
    <dbReference type="WBParaSite" id="DME_0000480001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000480001-mRNA-1"/>
        <property type="gene ID" value="DME_0000480001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854121at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF4">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000480001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16694" checksum="A8A01EAC17E11F69" modified="2015-12-09" version="1">MNEFQVYYRPVNFTDYCYNMPPDVHIGITPCSHSICITIIEPRILAGYHIGNYVVRGCFSTVFKLMQNLVEHTTPTIVFTDTACKRVPASQLLPIKFAERSSNRTVELCWCIGQLCNDYPTTYSKISALHHISSFLLLCLSVFYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC44</accession>
    <name>A0A0N4UC44_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2h2-type zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8701</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC44"/>
    <dbReference type="STRING" id="318479.A0A0N4UC44"/>
    <dbReference type="WBParaSite" id="DME_0000481801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000481801-mRNA-1"/>
        <property type="gene ID" value="DME_0000481801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5576026at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003389">
        <property type="entry name" value="LOC100006898 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003608">
        <property type="entry name" value="Zinc finger and BTB domain-containing 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000481801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29837" checksum="1ADEC6201371E5DA" modified="2015-12-09" version="1">GDQSNLPDSPNEETGPTQSDATAAAVAALPNLLLAVSGSHTNKPSKKSFSCPHCNFHTSMSQHMKSHLAHRRHRGQMYQCDLCQMQFSQKANMHRHRMRHAGVKPYECLYCAKRFFRKDQMQEHSMTHIKAGKNFDCPIMNCTQRFSQHASLRNHLETDHIINANNPASCKRCSLLFVNPRRVLLHYQTKHDPGDVGSCRFPYFLFFYLIFLDETLHLVHSGLHSDTDPWKCKLCGISCGEKYSFNAHIILSDHSCGAFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCX1</accession>
    <name>A0A0N4UCX1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8935</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCX1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCX1"/>
    <dbReference type="WBParaSite" id="DME_0000513601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000513601-mRNA-1"/>
        <property type="gene ID" value="DME_0000513601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720919" description="Nuclear migration protein nudC" evidence="7">
        <location>
            <begin position="24"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="158"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000513601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37072" checksum="C971CC42AEFAFA37" modified="2015-12-09" version="1">MLTFVENQHPMLILFLNIRMCSCMSLNSTCGSCFLARKTDFYVGAGIDRAREMVLQSFDKHSLAAKKAAEELEKKKAYEEKRLEERRAAQKAKEEAELLEPKIQEITDEEAERIMANGNNQEQPSNSSDIKEAKENNDEEEDDEEDKGKLKPNAGNGCDLDAYQWTQTLGEIEVRVPLRVGFPIKAKDVFVEIRKDNLKVAVKGHAPVIDGKLRASIKTESATWVIEDKKAVILNFEKCNNMEWWNKLMENDPEINTKKVKPENSKLSDLDGEMRQMVEKMMYDQRQKELGLPTSEEKKKQDILKKFMEQHPEMDFSQAKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCZ4</accession>
    <name>A0A0N4UCZ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8962</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001174">
        <property type="protein sequence ID" value="VDN58989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCZ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UCZ4"/>
    <dbReference type="WBParaSite" id="DME_0000516301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000516301-mRNA-1"/>
        <property type="gene ID" value="DME_0000516301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000516301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45903" checksum="0E5CD8BEB355DD9D" modified="2015-12-09" version="1">MTISGNCKNMSDICETVTKIPKAHSRSIVDVEFVKDPLTATVYLVTCANDSMKFWKTSNINDWSQFELHQEIKGWRCGVQSFDITHDGKLAVVVGVESTLHQIITDLEEKRETVENFNIGLMEIWHVCIIPNKTHYLTVSFSGSLTLLGNNGEVIKSTPFNGVRQISAIVCSPNGELIAVANNEGVVIIINAATFESKFFFEAHAVKVRALCFSPNSEEILTGSDDKIVKLYAVKETKAQFKRNFCGHRDLIMSVKFSHDRDGQIFGSCSNDGSVILWNVSNEHPLHVFREIHDGIATSFAFSFDMQFLISVGEDRLICVHRISKGKMEEYCGVSYIPENVYGEFSANTPVNYQPLSSPVYDSNGQDHLNGTNRNQYHQKEPSLTNREEEYGDDELMAIAKADAEAADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD98</accession>
    <name>A0A0N4UD98_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9088</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001176">
        <property type="protein sequence ID" value="VDN59115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD98"/>
    <dbReference type="STRING" id="318479.A0A0N4UD98"/>
    <dbReference type="WBParaSite" id="DME_0000528901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000528901-mRNA-1"/>
        <property type="gene ID" value="DME_0000528901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876225at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052667">
        <property type="entry name" value="E3_ubiquitin-ligase_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156:SF10">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156">
        <property type="entry name" value="PROTEIN CBG20824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000528901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31160" checksum="43E8643A06156899" modified="2015-12-09" version="1">MDAAKCLCVTPKQLECGHTICDVCARRIIDLSTASYINCPICRGPTEVPSAGLQTNYALSSVIEFVCSGSGRCSLCSFMVIEKLFCFTCDKNNAEARILCTTCALNHHALTGHKLQAFQKPDVNMLSGTANRILRDKDRLEASISASFSRLSNTISCCSKQFGKFLSEIVELSNNILCGDAPQSLCLNQFANAQKRFKVVELLAKRYVSIMRYAEVELKNFMEFAGNLLKESENNYELVISRLTLEQPILDASLVDHISSISPFTFSENGRTKQRHGNSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDG5</accession>
    <name>A0A0N4UDG5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9176</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDG5"/>
    <dbReference type="STRING" id="318479.A0A0N4UDG5"/>
    <dbReference type="WBParaSite" id="DME_0000537701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000537701-mRNA-1"/>
        <property type="gene ID" value="DME_0000537701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5968863at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990698">
        <property type="term" value="F:palmitoleoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000537701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32159" checksum="E8E4358A7B411AA3" modified="2015-12-09" version="1">MNACFNQESQKLNPIYLMQFLIPAESFIAMRGTLMVILMKISSLSFDLDNSSLSSDKKIPYLSFLSYTIDPSSIVFGSWVSYTHFVDSLKLQTLKEELYDLLYGSLLISLSLIFVIYSSCVVNELFSGIFFWHQFGVAQSFRFSHYFICWLSAGVLRISGINTGFISEWYRIEWPRSLVDVVISWNIPMHNYLHKYVFVEAKRFGTSVAVFITYFISSFLHGINFQISAVLLSLGFYTFAEAKIRNRLSKRLNCCIGARKCRENCKHMYKEVRVLNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDJ7</accession>
    <name>A0A0N4UDJ7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L23, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9211</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001178">
        <property type="protein sequence ID" value="VDN59238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDJ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UDJ7"/>
    <dbReference type="WBParaSite" id="DME_0000541201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000541201-mRNA-1"/>
        <property type="gene ID" value="DME_0000541201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000284">
        <property type="entry name" value="39S ribosomal protein L23, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000541201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="19158" checksum="7BC75E3211186FE7" modified="2015-12-09" version="1">MTTRTHRLWQPGNPQLRVFLPDFWIKILQTPDYGREKLPKNCFKCEVDPRMSRYDIRQYLEKIYKLPVRDVRTAVVTGEITWDLKLDREKRKALWKEKDKKYAFVFLKKGIEFRFPEIFAKDQETENLNKIKEQQAQLSKNWDFVNRDRKNIGEWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDT3</accession>
    <name>A0A0N4UDT3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS614</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDT3"/>
    <dbReference type="WBParaSite" id="DME_0000550801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000550801-mRNA-1"/>
        <property type="gene ID" value="DME_0000550801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000550801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4432" checksum="38B68FAF7B7AA8AE" modified="2015-12-09" version="1">MTAATTKCNVAQPGMDNGHYAIGVGTHLLVILQFPILFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEU2</accession>
    <name>A0A0N4UEU2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DME_LOCUS856</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEU2"/>
    <dbReference type="STRING" id="318479.A0A0N4UEU2"/>
    <dbReference type="WBParaSite" id="DME_0000591701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000591701-mRNA-1"/>
        <property type="gene ID" value="DME_0000591701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN50883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000591701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28563" checksum="706A48000F37F8AC" modified="2015-12-09" version="1">MLKIFIRLPSFAFTSFLARWEGFCQGVIWRQIDATIFTQFFCCSWNAYVHIFCFISGRYSLVPSASVDFEVVLNDVSKIRSLTGEKRMNAMNDVVQYIEENSIYAAHRSKAFLLCHFSFGAISSLLYIAQKLITFNISRDDWTETGFFPYIVFCDYDKFELGNVQRKTVQCTLPINMFNEKIFICLTLWLLCLFILTSVNVIYTFLVLFVPQFRDRLALFYFTDGNHEGFDADCKSRECEFSGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF29</accession>
    <name>A0A0N4UF29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS958</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF29"/>
    <dbReference type="WBParaSite" id="DME_0000601901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000601901-mRNA-1"/>
        <property type="gene ID" value="DME_0000601901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813706at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000601901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22069" checksum="0F0BBECCAAA62983" modified="2015-12-09" version="1">MFMSIKISVICALQERMIAYEQYMKNHILYVNAGWLAEISTFFLSVFFPDHSHSSEVILSSEILYEDVLELLRVVCYCPRKKPITVSNVAVVLQMAHYFGMQSVLESCRNFINHNVDTLSRTRLFQLTCALAQCDRHSPTMSLLIDKLSTIKEEELSALHFSEVPGDVVADVFATKIKRNQLKKRKWCCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF43</accession>
    <name>A0A0N4UF43_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">H15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS975</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF43"/>
    <dbReference type="STRING" id="318479.A0A0N4UF43"/>
    <dbReference type="WBParaSite" id="DME_0000603601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000603601-mRNA-1"/>
        <property type="gene ID" value="DME_0000603601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN51002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000603601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25279" checksum="BA5A412FEF4FE02C" modified="2015-12-09" version="1">MSTEVAVNESVSMGESPSKKSPVSKKRRGKTKAEKMASNHPPYGDMIKSAIIHLNDSKGSSRAAVLKYIIQTYSLGDNLAAINAHLRLGLKRGVASGMLKQVKGTGASGSFKLSESKSDSKSKKNAEKKPAVATVKKSSPKKVTAKPKKKANNSQEILKEFIIHHHLLFIERMKITKTKITKSPPKKVEKTKPKKATASATPSAPVADSAKPKTTATNKKSKATKKATHKGKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF68</accession>
    <name>A0A0N4UF68_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosinase_Cu-bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1004</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF68"/>
    <dbReference type="STRING" id="318479.A0A0N4UF68"/>
    <dbReference type="WBParaSite" id="DME_0000606501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000606501-mRNA-1"/>
        <property type="gene ID" value="DME_0000606501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF50">
        <property type="entry name" value="TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000606501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51034" checksum="F8434E956C74F053" modified="2015-12-09" version="1">MKETCEQLRAFDMLARRNAQNIIRINRQIINAPGVPNNPRLTPAVPNNSFIPYAYDCMDMHCLCPYFRGMTAPDGRCFLTNGMELRRTVRKEIRMLTNDELQRLNNAIRQLKLSAIYDQLANIHRQFASGTGAHSGPAFLLWHREFLKRYEISLRLIDPTVAIPYWDSVMDGFLPDPRDSVLWTPYLFGETDQANNVVTGPYGNDFRTLEGNPYITRNLGIEGHLFTEKNLQDFYNKQSIDGVLAYTAPQSGCIYPPNFGALEYSHASVHSWVGGDMKPPRRSANDPIFFFHHSFVDFIFEQWRQTKQNRFQREHQYSPNIEQCSSPLHFSHAPMRPFNILNIQGLSNSYTDYMYTYEPRPTCSIRSPSCNSQYLFCSIRNGISRCISKVKMNGNCRGFEQDDACYNGMCINGICRPPPSTLVTFQHFICPLQLRKQYLPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG28</accession>
    <name>A0A0N4UG28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9533</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001184">
        <property type="protein sequence ID" value="VDN59560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG28"/>
    <dbReference type="STRING" id="318479.A0A0N4UG28"/>
    <dbReference type="WBParaSite" id="DME_0000642201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000642201-mRNA-1"/>
        <property type="gene ID" value="DME_0000642201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862080at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000642201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60411" checksum="47AAEB2FFDC590A0" modified="2015-12-09" version="1">MNGTTMDICDSCINELSHNLKSDIYSSTEIIANGDSINTKIIQMACSEDEALISCKTNTEDVLMKIFENVVENLELKGKNKKANALHQVAPIVFIIMQTALRKARMNEEVDIGLLVFEQIRKLVDIDRKRMENLTFCIDIIFYLVQSRVSISNLDNEVCVQTTVIKAKVENGKNDSSNIISTVYEPPSSMEVSHSVDSRKSDSDTGQVEIRANILLKEFHDSEMEDLTRACSTDQILFDLPNSELESISFFQEKGILPKNCICQYGHSLELFFDLNKNAYFWKDNHASCKNVICIRTGNWFSGINSINLSFMKIIRFIYGWSHELTTIKWCKQELGLYPTAVVKLNRYMRKVCIEILRKKGTMKIGGYGKIVEIDCSLINNYGCRQVFFLGGICRETKECFVVEVPDLNALTICNFIKENIENNTMIYSNCWEKYGKTEMEKACFSQFMNDHAYNFVNPDTYLDVANIDKLFYSAKWRNIQAMEIHHVESYLNEFIWRNRLLNKDPFDEILSNIKECRPPQVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UG98</accession>
    <name>A0A0N4UG98_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001186">
        <property type="protein sequence ID" value="VDN59642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UG98"/>
    <dbReference type="WBParaSite" id="DME_0000650401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000650401-mRNA-1"/>
        <property type="gene ID" value="DME_0000650401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000650401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13536" checksum="B3A4729EDA47BE22" modified="2015-12-09" version="1">MESCWHVLTELTCERLERLEAPEAGHFWRTKGGDLFLLKLFLRRKNSVLAGQVLSWIVIEIASTQFDQQVSRHYGFSFYLVMANHQNLKLDWSCELIDSLVPISPSAKMAIPVVNEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH90</accession>
    <name>A0A0N4UH90_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1513</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH90"/>
    <dbReference type="STRING" id="318479.A0A0N4UH90"/>
    <dbReference type="WBParaSite" id="DME_0000689901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000689901-mRNA-1"/>
        <property type="gene ID" value="DME_0000689901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF50">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000689901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56175" checksum="5AC2AA729181A769" modified="2015-12-09" version="1">MEILNEDCLALIFHKLDFLNRVRLETVCYKWFHVLQIGAGYSNVTQVNMADFLPTNSTDYFQQEVITFAPIIMGIVQRCGCYINTISLGQRWSKISQNVIDTVTKYCNQLTTLDLGCIILDADISELLEQSSANLEILSLEETSWVQKENGDKVQDYFHKMIRLRKLNIRRAIFQLDKLHHLPQCLRSLEMSGVSSLTVKSFEQFLTSHLNLEELFICPLSIPENPIVSKVGSLSKLHSLQIGFIHSNDLSMQPLALCTTLQNLHIQNCNSLTTASLALILESLNSLLSLTIINCPWVLDYSSLASGRTIQILRIEHTHRITDDDIISIGVLKILKCLYISHCFNITSISILSVLRNCELIDIAINDCEGIGDEIFYSLASVQHMMRSISVQGCFNITSQGVALLALMKKLLELRELDLSHNRNINDLAILSIYNGMQMRKYEKTLEKKRVNKSKKKISKNLDGENLPMLTIYVFKTSLSPNIEERVADMIILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH92</accession>
    <name>A0A0N4UH92_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1517</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="VDN51544.1"/>
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            <dbReference type="Proteomes" id="UP000038040"/>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000690301-mRNA-1"/>
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    <sequence length="164" mass="19073" checksum="2815831EAC13F530" modified="2015-12-09" version="1">MITLGKCCWIFSKHHFIRGDSILLLLLLELFCDSLHDSKTKEIFLNNLDQSVKFESNGVFLSAPLTQKYVCKDRMNISLHNQHFKDYILELEPEIEAQPYRADQQTNVYICEKTRRRTLAESFQNRITVASGVVLCLSSVSTMIGYSVRRQLHPSKRQLYQSLK</sequence>
</entry>
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        <scope>IDENTIFICATION</scope>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
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    </feature>
    <feature type="domain" description="MATH" evidence="2">
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            <begin position="23"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50144"/>
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            <dbReference type="EMBL" id="VDN51604.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
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        <source>
            <dbReference type="WBParaSite" id="DME_0000702501-mRNA-1"/>
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    <sequence length="356" mass="40867" checksum="0D5A2DB9068F09CC" modified="2015-12-09" version="1">MPFIIVTTVSTSVDTSSPSSSSDGILRLTIKNFKSMTDTVRGESKEIQSIPWRIMVMPRQHVVQKKGTQKCLGFFLQCCPNAYSDSWSCQAAAELRLISQKASVPHFTRKTNHVYTAKENDWGYSCFMTWADIQDEEQGYIKDDTVILEVSVKAEPAKNVLTQEQFRKKIQDYKRLADIQSSRGYLDKAIECNASALKFCRDRDKACREELEIQKQQLIDLKLKQSIERIEKGRLIYNLLFQITAAFQCYFFISILLYILEIKNYRLQTPPPPAKPTVEKRNFIEKIGTETHLDDLKIEKEIPMPGITAATCKDVCKNPKGQRKSGSLNFQKQLNQDNFDFSKIIFIVVVTLLDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHU7</accession>
    <name>A0A0N4UHU7_DRAME</name>
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        <submittedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
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        <name evidence="6" type="ORF">DME_LOCUS9876</name>
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        <name type="scientific">Dracunculus medinensis</name>
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        <lineage>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DME_0000714601"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
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    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
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        <property type="entry name" value="ENVOPLAKIN"/>
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    </dbReference>
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        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="133"/>
            <end position="240"/>
        </location>
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        <location>
            <begin position="1074"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="3354" mass="381997" checksum="9A6FF0F1CD57D66F" modified="2016-06-08" version="2">MYKVLRSYSKKAERKHELTRSNQANSYGYSANGYNTGLYGRGVDENIYGDEQQQQVAIDGRERNEWNVGVGGAEGRGKAFSESSSYEAREHFERKVKRVKKTRAERDSTRKSKKNKTEMLLSPPQSVNNIDMLSAKDALLEWAQNVTRGYPGVHVKNFSTSWRDGLAFNAILHRYRPNSINWNKISDSNVKAQDRLNNAFNVAEKEFGVSRLIDAEDVDIDNPDEKIIITYLSSLYNALPHSSLLYKGSLSDIISRLTRGIGITNEKLDHILQRIEETEVKVETLRTTDLQRTIDMIIDDLNLLETPILEFFDDVEQLKQNKHPETNDFYQQVYGLEQRRQSYLTRIRTQFITKLGLRSELLLRESEERRESIRRSTFNRVEECIQWVRTRLDKLSEMEFYHELKELENMFEEHKIDNHDIQDFRQNVDECIARQAEICAEDSHEYCELLTTLESEYQQLRDLSAGRMLDLDTLIAFIRGVEQELIWIKERQEIEICRNWSDINQLDLPMLHNYYKQLLHEIELREPIFNDVHNKGAALVNQGHPANYVIESYLREMQRQWDILLSLSKCLEQHLRDANNLKMFMEDAKAAEEWMLKQADLLERKYSRNDFALDEGEQLLHELDEINDLLKKYHSLLMRLTDRSADISPLWQRGERVEQPIPVTAIASGYVVHEGDECMLIDNSHHHPWVLSGGPENTNFSEYSVFFRIPPPDSRLTTYLNRLHANFDRLRRLWDKKHRLVRLNMVLNTMGQIRGWDLDTFASIPADERDAIIRALNDDAQKLLAELDANDPLAIRLREELRLTNEHFYDLLNQMNRPKEPNTSSQFDEEVAKLLNKLNEANRKLNDRVTQSMPRSVNDLERLILEHKDFEEALQGLDVDISTVNELFRQLASPTPSQRANHDHLNGLWEDIWELSRMYVEHLKALEGVMNGIVEVSDILRQHEITLNSYDDLPASLERLRGVHSQLLEMNMVLQQQQSIVDSLNRNIALLRQHASRTRQSSNHPDVDRLEDEIQNLTVRWENICSQVAERMKSAERALQILMIYRPEYENELAWLDKVEETINSLRRPEDLLPEQYQQQLDQLVADYNQLQERTEAIENVNREGGKFIREAKSYDSRLSQYTDNIITVHGPRIKDEFRRTQPQPKNGAQQVTEELEKLNRRFAQLSSLILEKRNVIQVLIQNWKRKKQEEEDRLRAEEEEKRRLFEAARLKALEDADRLRRERKAAEDARRAAEEAERLRRAREAAEEAKRRAEEEARRRAEEEARRRADEEARRRKQAEEDRLKREEEDRRRREEEERRKALEDAERRRREEELKRKKEAEDEERRRREEERRRREDEERRRREEEERRGREEEERRRREEEERRRREEEERRRREQEERLRKMPEIRHGMQQAIVPEGMEAEEFEELSNVPARATIAEHEDEMQMYQEETITKTQFYEMEGVLHKQTGEILTFVEAVRQGLLDLHSGGGEFYDIVSGARISLEKAAELGYIDGGFHEVLNAHHGIRHPETQQSLSLLEAIQIGLYDPDIRQLRDINTGEILSMYDSIFRGIITLDTQHRLLKMGVLKLPPMSLENAIEQGVVNPESGHFTGKYTREMMPLKEAIYNGYIQIKSGKPSPMIAICLTDCIQLELIDAFSGEFKDKFSGEKISLRDAVSKQNSLINLHVPEIIRTDEGIRVTLGEAIVRNAINTRQGNFTDLQKSQSLSLQEAYSQDLIQKPMTLTEINAKGLIDSTNKFIDGGTKHRYSLLEAIAAGLIDAEVRHIVDPDEKDVISIAEALERGLLEPDGNIVLPNQQKIYSIAEAVSEGLLIKRVRHTIFDVKGIKNTKTKENLTFNEAVEAGAVILQAERIVDLANHDSFLLADSAGKDLIDPVLHELLSTPLGIKNHSGQDLSVFRAAAKGFIDPLKGVFIDKKLNKELNPKDAYDAGYITLRGALKLSALFDIHPSLVTPVKKVDFKRRIHRPGAKKYDLASDQIKVTLAEAMKQGLVDSKTHRFRQGETEMSFEDALSRGLIHPSDEWIVPSKSAGVGPTIEERISETVSETGQQLAPKFYPDKNIEETVTTIKRIKKAETTAVGGPGGVSVYRAITGGKGTIEVPIDGYHLNEAERLGYIDLATGIIVPPNVDRTLSLEEAFELGVINSKNIKVLDPQTGTFIPVIKAMEKKIMDKNGFVKSGDRMLNLQTAIERKLISVEPEPPSLPSTSPKKIIQFSAGTGAIMSFRPVGTATVDESEQAWSFDSTTGELFDHIGGERISLDVALRSGKITTDDLRVRDALTGREMSFEEAEKWGIVDSKNLYFFDKQDNKRYSLTEAAQQHRIFPTGGVPENASDAVHTTYKIQKRTEVSKKEATTSGPAAFIDQTLTKAIDCGWYDKTSGRFTHPDTGKQMSLKEAIIKGLFNPYGTTIIDKRGQRELSLLEAIQENIINDNTGELLDTSTGKSVDLKTAMQEGLIKGCSVPDSLEGAIVSGKLDLATGKFSTPDGHAITLQEAIKSNLIDSKSIVIRDPATGEEMTYSDAVDKQILNPNEGTVFNKNTYESISYPQALARSVLVGAGSRHSQDTQKRTHPPRLIEQKLQLTPYVQPYDQKQIVSLKEQRSIGPGRQEMVDLGGGKQVMVKVVRGEGGIEKGEYIDPLSGMKFTIQLHGDPYVTETKTVVKSTAQVHSVQLEPHAEFVGIDKIRDKRTGRIMSLQDAQRLGIAQVDKKGKQMTKTYSVFRSNIQNAITKGVVDSHGEKISLEDAIRAKLIDIKNLTYLNSKTGEALTFAQAANMGLLDVTLSEILPKGVCHPANGEKISTERAINLDIINPKTGEVRNPFTKEKLSWLDILKPVYASLTMEGVYDPTKGYGVPVSSALIEGLIDANTGQYSNPITFEKISLMEAKNKGLIDEETYKAITEPFLIDFRTKRKLNLIEAVKTKLIDPRNRTIQLDEGLIIPVARATAEGKIPRSIGERLKKVDKLTFAEALGKGLIDVAQNKFIDPDSGRPMSINQAIEEGYIDTGNVESIEGSDQRNLANILHSEEFDENSGRIRDKKSGLYLTFKAAVERDIIDGDSLFHDIDSSHTMTIREALNRGKVDADGKYVEMKTNTKMSLKDAIAYGLIALIPSPMQAAQAVTEAVKRRETEGYKFKIGAVDERKPTSVGPRFREESTVIRLSQPHRVEPGLSVRVRSSSEAQSTGSRARSLIDDPQALADLQHEFLDSLIKEQFDIEKQLIENPATSKRVSIREAAESGLLDVVTGEMVHPLSGRRYSIPRAVHMKLIEPDVAKCLMESLNLSLEELGQSASISLDSPAGLSPSDPSVKVWTKTVSWHGQPSELRHSTDPLAPYTTYTSSSSTRSYDAPSWARQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHW7</accession>
    <name>A0A0N4UHW7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nsp1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1638</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000027">
        <property type="protein sequence ID" value="VDN51665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHW7"/>
    <dbReference type="STRING" id="318479.A0A0N4UHW7"/>
    <dbReference type="WBParaSite" id="DME_0000716701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000716701-mRNA-1"/>
        <property type="gene ID" value="DME_0000716701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="10">
        <location>
            <begin position="642"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000716701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="835" mass="85660" checksum="3F7C993B4A2873B3" modified="2015-12-09" version="1">MFGNSPFGTQTTNATTTTTSSIFGGASTTTATPPTGFSFGSITKPASSSPFATSNTGSLFAKTNPATTTTGGSLFGTATPSNSLFSTNITSPASTGSIFGSATSSSLFGTPTSTVGNTNVGTGFFQSSLPPTATTQTSNTSLFSTPQTSASSIFNFGSSASTAQGQQQNTASSTTSAAAPPIFSFGSGSTSTTTSIFGNAVTQPIFGTAIPSTVTSGQTTGLFSSLAASTPQTTGLFGTSPVTTAQQNASVGLFGSATTTQIPSSTPQFGTNIFGKIGTETPKQTLFGASTFCSPTQGGSSTISTISSSTPFSATTTTTQKSLGLFGNSTLAQTTAPTTTQQQIPGLFGSVMNATSSSTQPTSNIFAPTTVQQTQQTSSLFGNLQNSPQFGAATTTGVQQATSLFGSATNAQSNFAPSTGITTSTVTSGLTFGQKPFVPTLSATTTTSTAPSTATITSSTITTTTSTTTTSSFALSQPNTTVVATTGQTFSFGLMSTPSVNATAAAPITTTSVTNSAPPFGLTSAASTVPSFPSFGLQKSSTTSAGLTSGLFSTPLSTGAAITTPLVVPSLASTQALTTSSTTPSLPSSLSSSLPPSTTITTSLPLATSAPSTFAATTVAPTSTATASTAPATALLSAEKPVQFGQLEQLLNRLVLDVQAEERSFMDHVLELNAYDRVIRKNEEKILSFAEDIKVMEQQKDQFIHSVDFLSQQQIEMEAIVNDMEKSLGLGEWSEMKPIELPDPSVATRADLQRQALLKLQLHVDAQLKQIGDDINDLNEELEELQKPSEKDNDAEDSVETIAQILQRHLVLLQWIDKESDQLRKKAAKLLEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIF9</accession>
    <name>A0A0N4UIF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS10030</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001200">
        <property type="protein sequence ID" value="VDN60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIF9"/>
    <dbReference type="STRING" id="318479.A0A0N4UIF9"/>
    <dbReference type="WBParaSite" id="DME_0000739201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000739201-mRNA-1"/>
        <property type="gene ID" value="DME_0000739201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF111">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE AGE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="9">
        <location>
            <begin position="196"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="353"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="780"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000739201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1082" mass="126220" checksum="4AF4A8DDD7C0FCFC" modified="2015-12-09" version="1">MLTLKETCAQDSPDVWSMVECGQIDPGIDADLDIMLPNGFVIAIQFSTDKTLLLLKEEVFDRAKRLPLFNLLLFPSDYIFFTIGSSGDYDELYDETRTIFSLQLFVPLLCLKEREGNNEEKALSHDIGLAIGHPLSNIESKLTYDYECYRMDLYKVMEEAIKNRGVNGYSHYAFPEEVSSEFDSDIPSQLKSKIQVADLFIEIWYRSREDEINKDDSNCVFVKLRKIIGARTTDIVANAVQELLRQHKIAIDQPPSEFLLQIVGQQCFVTKDMKITSFEFLSCSSKSTEVWFQYVRSCFENYRIPKFLLRRKDIVLIDFPVPPLPLKPSWTKAYEERLNKPYQNMKRLCLWELDDNLKIRVCSASHITISDIDRIYVRATIYHGHILIVSKESEYVRPSNPRWPNGWIDFDFYLKDLPYSVQICLSLIAVKEKKKEEHSGIGWVNIRLFNWNDEMLQGKKLFYLWPFPKHCTDFTNPLGQIGSNDNKDAARLEIEFFDYDYIVEFPSSDLIYKYIEKMNIRNSTITPSPPILKASSSEITQLMDLAVLDGEKLSIKQQQFIWSMREFISVNMPDLLPLLAGCMYIWITRDRFAKFYELLDRWAPIRPETAIILLDFKYPDRKIREFAVKCLDDNLDNDRLHLYIMPLVQALKLEPYAVCALSRMLLKRALCNYRIGHIFFWLLRSEIAQIGEVGEELPRMYIRLSLLIEAYCRGNFIHMNSLLRQVDMVARLTSLSKLVKTFKDRDAAIKRLQLELSNFKEEMQNISSPLNLRDSLGILNIESCKVIGSAKLPLRLSWLNAEPLARLDNLTHQIIFKNGDDLRQDMLTLHVLRIMDALWKNQDYDMCLSIYEVLPMGRNVGMIYVVQNCNTLFEIQCAAKQLGSTFNMESSLINKWIRNYSEDSKFYLECVDRFTASCAGYSVATYVLGIKDRHQDNIMLAKDGRLFHIDFGHFLGHYKKKLGINRDRVPFVLTDHFLFVIAKGKSNFRENHEYKKFKQLCVEAYLVLHDHARLFISLFTMMFCMGLPELQKMEDINFLRTTLCVELDREEAIASFLKIFDEAFSGAWSTKTNWFFHSVKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIL1</accession>
    <name>A0A0N4UIL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10015</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001199">
        <property type="protein sequence ID" value="VDN60042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIL1"/>
    <dbReference type="STRING" id="318479.A0A0N4UIL1"/>
    <dbReference type="WBParaSite" id="DME_0000744601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000744601-mRNA-1"/>
        <property type="gene ID" value="DME_0000744601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin-17/31 FERM" evidence="2">
        <location>
            <begin position="221"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000744601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38207" checksum="98742CB03603B846" modified="2015-12-09" version="1">MEKANKNKIKYTYEQPNQAYDIHVNGSYHASIRYSELLLLHERLRTKFQSNLRSVDFPPKKFFKNLDEKAVKERRIGLHIISILQDSFRPSSNKVSLDIYLADGSKESIRCGADNSTEVVLKVCVRLLGNHESPYISLHLLNQKSASSGIFYYIMVRKIMWHKMIEEQLLDDPGAVILLYKQKVGQNSPLFTRLQNPLKLFLLIFQLLRLCYENSLGSFELLESCITDYPQPNTNCNVKIGFRSIILQPTEKGKDYVFRVTRIRMWRLLHDSKSCDGFSLQFEYFISKNNFLWINVLTKQAILLTRILQTIGFEILKESERKVCFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIZ6</accession>
    <name>A0A0N4UIZ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome-binding factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1867</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000035">
        <property type="protein sequence ID" value="VDN51894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIZ6"/>
    <dbReference type="STRING" id="318479.A0A0N4UIZ6"/>
    <dbReference type="WBParaSite" id="DME_0000760001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000760001-mRNA-1"/>
        <property type="gene ID" value="DME_0000760001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000760001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29588" checksum="0C0C2784C234EB4F" modified="2015-12-09" version="1">MHIRINLRDAAFREVSSANHSPCRPMYMQLGYSREYVESLSVKREMLISSLNSKLFAPKINLRFLSVIDICISNHQRYKTGRGSSSEFLYRHRLKFENSKMKVFTRYTGKKLGINLGLSDLNLLLSSASRYKSRILSERKRQKLQTLFMEHLMNIIVMDSELSGKKLEFSKDTIELLEKSRYRLEKNLSEALCHCTVPHIQFVIDKSRSREMEIDYLFQLIKSDGGYSKVTKINKINSLDDSNNEDVQLQGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJH4</accession>
    <name>A0A0N4UJH4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS10182</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJH4"/>
    <dbReference type="STRING" id="318479.A0A0N4UJH4"/>
    <dbReference type="WBParaSite" id="DME_0000781201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000781201-mRNA-1"/>
        <property type="gene ID" value="DME_0000781201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="9">
        <location>
            <begin position="238"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN60209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000781201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="839" mass="94649" checksum="32929B92B8B82618" modified="2015-12-09" version="1">MSSITIGDSDVGSSVNTASYDAAVMNGKAIANNVKLKAQLDSDISFKKQNIQIKDEHTNVENRSDTKSANLKFDFGDLLSELRSELSSKRLEEEKILKNIDEILEKTIANNGGTDISRPFNFAVTRLNNQMTLVESDAKQLANKLKMISGLADNISSKVSTLDIAKSRVVECMQRVSDLMDLRTCAQGVNAAMDQEDYELAAQHIHKFLTLDTAVFQMGDQIEAKDTGQSMKVNYEVLREATEKLKAIVESKFDEAVAKNDVASIQRFFKLFPLINDHMNGVTRFANYLCLEIQKFAEKNYKVMLAGGTDDKRSNVLYADSLTMLFEGIAREIQVYEPLIDSFYGPDKLLSLIEMLQKECDKESCKIIAAFIKNRQYDTKAKLIEKFSRNRDNYNPSEKINALELDTILSEVTLMHTRAELYWRYLKRRLNAANIKTDEQRANAVSHFSEEEAVKSNKATALQKDDRDRKLDNLLNRSALGTKMQELLGRYILMEEYYMKESLSKAMAMDQRESDSLTSSMLDDVFFILRKCIRRSLSSSSVDCVCAMLNNGATALEIEFFNYINTGIKNGYPSVGWTAEAYQTAQTAYNVIQHGKTVSDAGPEKQKEVFLTALNNMRASVDCIKTLNKGLLEDFEKHLNQVTATGQFDDLIRKFNNAANIGVEKLCIVAFRPKIKSSTEAFLNVTHTPTENEFADFIAVDPFMDNFIASLDILLVSFEPLLVRANYQELLAAVCSEICRQIERVIHKSVFNRLGGIQLDKDFRSLISYLTGTAGWIVRERSIRLSQIVSLINVDSVEEAVEYYQQLQHTRLVGSDEAKKILALRTDLSPHSISTAIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJM0</accession>
    <name>A0A0N4UJM0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10212</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJM0"/>
    <dbReference type="WBParaSite" id="DME_0000786301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000786301-mRNA-1"/>
        <property type="gene ID" value="DME_0000786301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000786301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9786" checksum="F0C0EF6E9BC86B64" modified="2015-12-09" version="1">MIRRFFNNQLNVKLINAAPAKIVIVRLKYRNIVVDVTAGDNGDDAAAAAVAAAAAADDDDDEDEDEDILFLLLFLALIYYPINFLISQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK77</accession>
    <name>A0A0N4UK77_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">39S ribosomal protein L52, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10242</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001208">
        <property type="protein sequence ID" value="VDN60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK77"/>
    <dbReference type="WBParaSite" id="DME_0000810601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000810601-mRNA-1"/>
        <property type="gene ID" value="DME_0000810601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000810601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17473" checksum="F21BF500BE67756D" modified="2015-12-09" version="1">MRVTRILLRNLNKKHWDRRVWEIGYRGPLLPMLKGTGRPDFRVSENDVAVLRQRLNMEYQVMKYLATPYFTKEQEAAYIAEYGTPEEQREKEILESEQRRMPGKPKRISEWKNNSRVHANIGNLLHSHRTVEDSMKELINRHRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKJ0</accession>
    <name>A0A0N4UKJ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10320</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001211">
        <property type="protein sequence ID" value="VDN60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKJ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKJ0"/>
    <dbReference type="WBParaSite" id="DME_0000825901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000825901-mRNA-1"/>
        <property type="gene ID" value="DME_0000825901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000825901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15575" checksum="70A77117D6D2CACB" modified="2015-12-09" version="1">MTIYNFYLFNKDGCCVSYKEWKREKEAEFRLMYGMLLSLRSFSSKLSTKSGQQQVKSYETNQYKMNYLETPSGLKMVLNTDPLASGISELMRMIFQLYVDIVVKNPLIDPSNVISSEIFEKRLSELVEKHHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKY1</accession>
    <name>A0A0N4UKY1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM8</name>
        <name evidence="15" type="ORF">DME_LOCUS10366</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001213">
        <property type="protein sequence ID" value="VDN60393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKY1"/>
    <dbReference type="STRING" id="318479.A0A0N4UKY1"/>
    <dbReference type="WBParaSite" id="DME_0000842201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000842201-mRNA-1"/>
        <property type="gene ID" value="DME_0000842201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000022">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN60393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000842201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10774" checksum="9097036A6638FE68" modified="2015-12-09" version="1">MTQSLEAFMNKVISVITGDGRNIVGLMKGFDQTINLVLEDSHERVFSEESGVEQIPLGLYIVRGDNVAVVGELDEDLDKRLNFSKMKAPPLGPIWIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL12</accession>
    <name>A0A0N4UL12_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS2434</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45244"/>
            <dbReference type="ChEBI" id="CHEBI:62243"/>
            <dbReference type="ChEBI" id="CHEBI:85108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45224"/>
            <dbReference type="ChEBI" id="CHEBI:85090"/>
            <dbReference type="ChEBI" id="CHEBI:85091"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000061">
        <property type="protein sequence ID" value="VDN52461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL12"/>
    <dbReference type="STRING" id="318479.A0A0N4UL12"/>
    <dbReference type="WBParaSite" id="DME_0000845901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000845901-mRNA-1"/>
        <property type="gene ID" value="DME_0000845901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF2">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000845901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32460" checksum="CBC6E69C4E67FD33" modified="2015-12-09" version="1">MFIANGKFVNGRIIYFGQRQCSTNLFPRTEFIDIREASKNVFHVRLNRPQSRNAFTLPLWRELRSTMDFLATYSKCRSIVISAAGKSFCTGIDLKEGITVCMDISRKSRLIRDLIAVCQDSFTSLEKCPKPIVAAVHNHCIGAGVSLITAADIRYASADAIFSIREVHIGLAADVGILNRINRIVGNDSLTRELAFTGRDIGSSEALKYGLISRQFATAEECLNGALNLAREIARRSPIAVQGTKLTLNYSRNHNIDDSMNFIRTWNQSQLQSDDLVKAALLKEKAHFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL50</accession>
    <name>A0A0N4UL50_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL50"/>
    <dbReference type="STRING" id="318479.A0A0N4UL50"/>
    <dbReference type="WBParaSite" id="DME_0000850501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000850501-mRNA-1"/>
        <property type="gene ID" value="DME_0000850501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000850501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="26567" checksum="31076F368E851445" modified="2015-12-09" version="1">MYDSQLVMVDQNRSLLMIREVNENNKRCVATRIRWLVNPQFFRYILWLIAAPEFCIHFTTVLKKKFDLENDIILQFRFTDLFVGSIDHHWDFRISLLLNRSLELEKNLWLLSTYGGALSAMGDYYLHFAKEAGNISCKQLYLAYKLGNPVLISRCKLYFALSLTQRYSFRRAFEILKEQYLFAKGLKCEFLLHCCEGVWSKFRSIQLKARQKRIEMSKRSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULQ7</accession>
    <name>A0A0N4ULQ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2633</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000071">
        <property type="protein sequence ID" value="VDN52660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULQ7"/>
    <dbReference type="STRING" id="318479.A0A0N4ULQ7"/>
    <dbReference type="WBParaSite" id="DME_0000874201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000874201-mRNA-1"/>
        <property type="gene ID" value="DME_0000874201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000874201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33328" checksum="48065554713DD051" modified="2015-12-09" version="1">MSDNQDLLPSANNWIKSNRGTYRLDSVIGKGGYGIIFRGSSENASVAIKVEKYSKSMLHIEADVMRTAARKRCKHICQLLDWGAEKPNYMFIVMSLLGKDLQKLRNEQANRKFSLSTAIHVGLQTLEAIEELHQCRFISRDIKPGNFAVGLREKKKTLFLVDFGLSKKYIDKNGNHHSSRGEVGWRGTIRYGSLHAHLGVDLSRRDDVESWLYLLVEITKGSLPWRNLTDRKAVQTAKISARNEGREKFLENCPKQYDNILNIVDELNFKDEPNYDEMKQILLEVRNVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULR4</accession>
    <name>A0A0N4ULR4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2642</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000072">
        <property type="protein sequence ID" value="VDN52669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULR4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULR4"/>
    <dbReference type="WBParaSite" id="DME_0000875101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000875101-mRNA-1"/>
        <property type="gene ID" value="DME_0000875101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000875101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19930" checksum="F1B4770CB3DDD0C4" modified="2015-12-09" version="1">MLLNKWKLDSASCATRQIARSADISLNPPGFSLNISSIQQEQASRNEQTHHLMKKRAWDMALQPMKNLPMNMFMMYMSGNTISILPIIMIVMMAWRPVKALMSFNATFKPLQDEHTGTLLPHKIVFIVGNMLAVAMALYKLHGMSLLPNHASDWLDFQQPPQRKQFALISDSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULU5</accession>
    <name>A0A0N4ULU5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001219">
        <property type="protein sequence ID" value="VDN60502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULU5"/>
    <dbReference type="STRING" id="318479.A0A0N4ULU5"/>
    <dbReference type="WBParaSite" id="DME_0000878701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878701-mRNA-1"/>
        <property type="gene ID" value="DME_0000878701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976063at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20831">
        <property type="entry name" value="C1_dGM13116p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="287"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="719"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="804" mass="91654" checksum="378E14877548D0D4" modified="2015-12-09" version="1">MDSFIWLVLSWTIVGTLCYLFINKLDSNRQPGTAERELKSNGTTSSTNLYSSTIPTITRSQTNDWPNIILAWLYKNFQKVPDSLDAWIKSLNEAAKKISSPATCDIFFEGFGDKFNSSNPPKISNIVIEQGPKDHLTLKSTIDISEINLKVLSSKRLDDHLIVSKYDAKITDLHGEIEARIACIANQIYMMGCFKGRPELDIQLSNTERNSSEQVNCGLVEDAIRKCLVTAVTNISLTNPSSLPSSVIPTKFTSTQLIGSDVFSPLSPSTLKPALGQTKDIFIPPTPETIKQIHHTEIKPAIIESNKLRITIIRAHLGKNRDISQPYVVVEMDEPTQKYTSNRGSSKCPCWEESFDFTLSPASEEILFEIYEGEHSVLDNDQRFLGLAIVDFEEILKSSERVHNLRLEGRPYRNDNVSGTLTVEFDFLYDTNLASRGKQIHQNVVENVNEFVRSEINEDKRPAVYDPRDSFGRHDDIKRPELNKSNVTAVKTDLNFNQNASFQVSSLLQSRRENEMSPDRDMPQSNINVRVIESIAHRNQPTMFNEENDMNYMRTNAENNLRSEDVLPQTRNSPLQQISATSEAYTHNSRDRNKKNLTSSVKRDRSFFSELRDRLSGKYIRRAKSSDIGHEFDEAVSLPSSREPSRTRQPDKKKAKSETRSVGAKSKESSRSLYQNSTLVLEMEKNNKKRHYLIPPSVLIDPAASKIFQKGRKLHIYNEHTFVAAKVKDGIDCGICHRKISKSFTKQAYECRDCRLICHKHCHYKIDGYCTHSTLKNINIIKNIDWNEFLRNYQLEEFISMDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM13</accession>
    <name>A0A0N4UM13_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RPOL9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10502</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001221">
        <property type="protein sequence ID" value="VDN60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM13"/>
    <dbReference type="STRING" id="318479.A0A0N4UM13"/>
    <dbReference type="WBParaSite" id="DME_0000886401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000886401-mRNA-1"/>
        <property type="gene ID" value="DME_0000886401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000886401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25158" checksum="B7D8038A20FC713D" modified="2015-12-09" version="1">MLYPAEDKENRLLLYACRNCDHKQLSENPCIYVNKLMHEVDELTQIVSDVVHDPTLPKTEDHPCPVCKGRFAVFFQAQSRRAEPKALTQVLGQVNSGETKGALLFNHEGLLLAYSGYDRIDGKSLNSTNATISAALLSNIWETFERQGIFLIHESNYIISHRTREHLREMLLECEDGVIIVTQVARMLLALKGSKNVPLGLLKAKLNALANYLLTPLTVVSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMB4</accession>
    <name>A0A0N4UMB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10530</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001223">
        <property type="protein sequence ID" value="VDN60557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMB4"/>
    <dbReference type="STRING" id="318479.A0A0N4UMB4"/>
    <dbReference type="WBParaSite" id="DME_0000897901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000897901-mRNA-1"/>
        <property type="gene ID" value="DME_0000897901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8114442at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000897901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9213" checksum="C3E16E18D87ABB40" modified="2015-12-09" version="1">MKSSFQNFHDFKFRKERRHICEICGSSFGRSGGLKRHFIMVHTNRKFYCNYSGCDHPGFKCSKALTAHIRSKHTFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMQ0</accession>
    <name>A0A0N4UMQ0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2874</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000086">
        <property type="protein sequence ID" value="VDN52901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMQ0"/>
    <dbReference type="WBParaSite" id="DME_0000913701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000913701-mRNA-1"/>
        <property type="gene ID" value="DME_0000913701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000913701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5855" checksum="22A66AA26F220328" modified="2015-12-09" version="1">MKLFQYDYYNDLYEISCDAKPKNIFLSNISVIYEIEAANYIIEIQLVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNC7</accession>
    <name>A0A0N4UNC7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3116</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000106">
        <property type="protein sequence ID" value="VDN53143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNC7"/>
    <dbReference type="STRING" id="318479.A0A0N4UNC7"/>
    <dbReference type="WBParaSite" id="DME_0000940501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000940501-mRNA-1"/>
        <property type="gene ID" value="DME_0000940501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000940501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14118" checksum="092722CFDB525FE0" modified="2015-12-09" version="1">MSQQKFLLPCYSTDLWKYETAGCALIKLSRCDCADQIFTLTLRRVLKHRFRYLQPTLTYFIDFAAAFDSIERTALWRMMERDGVPEKIVRLIKAFYERTSAQVCVYGELTDSFEIRTGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNU7</accession>
    <name>A0A0N4UNU7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3271</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000118">
        <property type="protein sequence ID" value="VDN53298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNU7"/>
    <dbReference type="WBParaSite" id="DME_0000960401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000960401-mRNA-1"/>
        <property type="gene ID" value="DME_0000960401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000960401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8174" checksum="3434AB8AE590812A" modified="2015-12-09" version="1">METNKGDKFDPDNTKFQYIFDNLHQDFQRQISMVHQRSCQNRNNLLLLIERIFNYNNTYCHCDENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPQ5</accession>
    <name>A0A0N4UPQ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DZF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3504</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000142">
        <property type="protein sequence ID" value="VDN53531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPQ5"/>
    <dbReference type="STRING" id="318479.A0A0N4UPQ5"/>
    <dbReference type="WBParaSite" id="DME_0000995301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000995301-mRNA-1"/>
        <property type="gene ID" value="DME_0000995301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000058">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="7">
        <location>
            <begin position="28"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000995301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42676" checksum="2B691A157EEDBE47" modified="2015-12-09" version="1">MRNRWRRNMMPYPGSGYVPHMGPVFACRPAPFDIVLCEENFQKTRENDDSDLTQALTKRHQELTPGQIEQSAITTLVTKVKGAIEKMTTTSTTSSIVIEESREVGSFKKGTMIAGHNVADIVIVLRSLPTVEAVSTLGQRIVEDLKANDKEVYEYIPRDFGCEIKRSKAIVRLLITTVPMNAKLLDPDLHLKESVMISHMAALRHALWFEENAKNSTIKVVIRLIKDIRNRFEQFAALNVWIIELVSHYAVLNTPSDQPLSTSQAFCRFFQLLAAGLLLPTSPALLDPCEPDRRIHQCLTYEEMDQICSVSQTLLRIICHGGYKHVLGLETSKGGLVTETTFWGDVVVTPLEAAYTDKVMDPLFAEEVNSQKEKSVGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPY0</accession>
    <name>A0A0N4UPY0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3569</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPY0"/>
    <dbReference type="STRING" id="318479.A0A0N4UPY0"/>
    <dbReference type="WBParaSite" id="DME_0001004201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001004201-mRNA-1"/>
        <property type="gene ID" value="DME_0001004201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF110">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR DMD-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001004201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32255" checksum="CFCD81FCBF24A4E4" modified="2015-12-09" version="1">MTERVPNCQKCGQHGRKSRLKGHKRICPFRDCGCVKCQVVSERQKLMADQIKIRRRQRKDTILNITRDNITATLNVAAAVAANSSLPYFSSLNNLLYRQLQHSIQQSPLFLMNPTAAAAAAAANGIVDCSTINSLNYLQTRPDIFEKTVANQSQTNKLSDLPVILPPVPISTQSIGNIPLAAASSSSATSTPLSSETTAHDLGSSQIAVPVAINPTRSPTSLHSTSYNVAKNQDDNRFINADDNNNNTTNGVGQLIDNDQLFQSLLANVRMLEQKICLDVLQENSNPSAFVNIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ82</accession>
    <name>A0A0N4UQ82_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3673</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000166">
        <property type="protein sequence ID" value="VDN53700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ82"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ82"/>
    <dbReference type="WBParaSite" id="DME_0001015701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001015701-mRNA-1"/>
        <property type="gene ID" value="DME_0001015701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6374728at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001015701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16397" checksum="DAD630FCEAC0D1D8" modified="2015-12-09" version="1">MPKNVLENAGFVSEDSFVTHDIGSRLQIALEFILPKTTKCKIVLLDEYKESGNIIFQVDWYGKRFGSNETRERWHTGQPEKACSKYIKQLAESISRNNAIRYELVLSTVKQIRVLDLLDALPASSESARRLPNIAIAITAIICNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ93</accession>
    <name>A0A0N4UQ93_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10847</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001257">
        <property type="protein sequence ID" value="VDN60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ93"/>
    <dbReference type="WBParaSite" id="DME_0001016901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001016901-mRNA-1"/>
        <property type="gene ID" value="DME_0001016901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862950at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001016901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32244" checksum="5BA1EDC8EC8A0BDD" modified="2015-12-09" version="1">MDYGDTKRRVEQEIYEHHVTELIKTVPYPSRRSSIEKKIITEKKISCGEQKSPPDYKTTLKYLQGDISSLAADTSDRRYRKFDQSIGRDKSLPHDSDVSISFRETNGITPTLSKSITNVDSYGYDVHEIHTSEGGARIVQTHGSGLIHNHGSPIEQRDRSISEQKVIGDESFEQRTTLVQERAALKSADSKEVGFLASSRPTVSGIPSTITPGVYTVPTPTTAKNGSWRQISESFSKLRSDASLMTGGTDRSLHRAQKSSSCRQRFAKFGQKIINRTRYLIKQSLFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQB0</accession>
    <name>A0A0N4UQB0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3698</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000169">
        <property type="protein sequence ID" value="VDN53725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQB0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQB0"/>
    <dbReference type="WBParaSite" id="DME_0001018801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001018801-mRNA-1"/>
        <property type="gene ID" value="DME_0001018801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="207"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001018801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61925" checksum="D172A5604E396DE0" modified="2015-12-09" version="1">MLNGSWLADPSSLNTFVLTVYADLKNFHFHYWNCVPAAIYPRNVWQIEKPSVYSSSTLINEYLKKNGNKPFVLINNLPNSLAVIASLDLISTDYVIVFPDPSTKCDCPGWPLRNFVAALAYTRQDISNTKILCYRTGEQVKSVIIQIAWSLNEDDSLKENISIVGWDRNISGQLASRFMDLSTTMDPIQSVFCVYLLMKENVELNLRLMKWRLVPEINLQCYGDLKCLILGSGTLGCNIARGLIGWGVQNITFVDCNLVSYSNPVRQTLFEFSDAENGKSKAKAASEALLRIYPFLCAKGVDMKIPMPGHPVSNNEEEAVTKILKELVDLICCNDVIFLVMDSRESRWLPTLLACVHGKLAISVAIGFDSYLVIRHGVSHEPKMKIEGIYGDLSLGKGETIPGSLLGCYFCTDVTAPGDSVSDRSLDQQCTVSRAGVSMAASGVAVELLAALLQHPLRGESPARSGEPDESDTILGAIPHQIRMFFSRFQQMTPTVQRFDRCIACGPSVISSYRTDGIAFLFRVFNEPQYLEKLTGLDVFQSTDIALSNFEYDTDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQJ4</accession>
    <name>A0A0N4UQJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3781</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000185">
        <property type="protein sequence ID" value="VDN53808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQJ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UQJ4"/>
    <dbReference type="WBParaSite" id="DME_0001028501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001028501-mRNA-1"/>
        <property type="gene ID" value="DME_0001028501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0001028501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20665" checksum="3DAA961B332349D1" modified="2015-12-09" version="1">MSPVENALAGSLASVFAAFVLCPTELIKCKLQAQREVNPDVHSSSFSVFRDLYRDRGFCAFFVGLGPTLMREMPGYFFFFGAYEISRYYFTSPGMKKDDIGLLRTAVSGAIGGMALWTSIFPADVIKSRMQVSGGGNFQSTFMDIIKNNGFRGLYKGLAATLLRTCLASGCLFIAYEESKKLLRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQQ5</accession>
    <name>A0A0N4UQQ5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10887</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001266">
        <property type="protein sequence ID" value="VDN60914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQQ5"/>
    <dbReference type="WBParaSite" id="DME_0001035801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001035801-mRNA-1"/>
        <property type="gene ID" value="DME_0001035801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041119896" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001035801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15466" checksum="D0EA0EE45183896D" modified="2015-12-09" version="1">MLLYFCFFVFLVHGVKSGNDKAIENCNREVGGQQPTVDPSRCAHIDSPACTAIFPYHPAEKKIEKLNFSRWSDEKKIFPLFIADPSAGDHCDAFTLEMCRNAALNTIALMRCPMRCGLCDQAECPNTFDDAVCTALAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URF2</accession>
    <name>A0A0N4URF2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4052</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000261">
        <property type="protein sequence ID" value="VDN54079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URF2"/>
    <dbReference type="WBParaSite" id="DME_0001063101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001063101-mRNA-1"/>
        <property type="gene ID" value="DME_0001063101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039595" evidence="1">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001063101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16824" checksum="D414F330F8F7C6B3" modified="2015-12-09" version="1">MFAVILPFFLLPLTFAGNADIEECVKLVGDKRRPIVNSCPEDPVCSSIFLYDQGALDDLVKNLNENEHYKIPELCNKVKDFAAKTCPRTCAMCCKTKEFNCHDVNPDACRRLDRNICLTVPSVALSMCPFTCGLCHRPGAAGMCPDENENCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2T7</accession>
    <name>A0A158Q2T7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5174</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2T7"/>
    <dbReference type="STRING" id="318479.A0A158Q2T7"/>
    <dbReference type="WBParaSite" id="DME_0000081401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000081401-mRNA-1"/>
        <property type="gene ID" value="DME_0000081401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF70">
        <property type="entry name" value="PROTEIN MAB-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="252"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000081401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41777" checksum="CC53C48F9138E3B2" modified="2016-06-08" version="1">MLGQNTAITSYQISNYFNERVAARKAHIHKALHIVAKIVQEILKEVEAQEPRFISTLIDNNGRYEGVIVHSPNEYEIILYLNQMGVFNFVDDGSITGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFLTLVGQSIDKLSYNNMCKLMNDTSDVRIKINDKYIVQITCAFRCNAIWPRSANQWPRNNIPWPSPTIINDIKNEGFDLFSKETNSANQQQNKQASSMEGDAWAMSLNQAENSLLQGGSRRKTFSILKCLRDTHLDFPSSPITNYILKTLLLFECEKHFNEYEWEERYIGDRVIGVLLQLVSCLQCRKCPHYFLPQLDLLKGKSAHSLDQSAKITWKLVRQLMLNVRALENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q315</accession>
    <name>A0A158Q315_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS5795</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q315"/>
    <dbReference type="STRING" id="318479.A0A158Q315"/>
    <dbReference type="WBParaSite" id="DME_0000143501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000143501-mRNA-1"/>
        <property type="gene ID" value="DME_0000143501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
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        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="84"/>
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            <end position="365"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN55822.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000143501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41910" checksum="FCB1C76697D32C5D" modified="2016-06-08" version="1">MIYHLSYIYILRLIQNLRICDANFDRSLCWRRTEVNTTAQRKCPFTFCMNINGCQQIAQYKVERTCRADGTWADPVYEQCIEVIKNHPQCIVGFCKTCPDFLRDLVIGVSLTLSIISVALLVTAIALFTIFDSIQCRRLFIHKNLATAFVFRFAVLAVWTILQASNAFQDCNFFNAVPILKYEWMCKLLLWFVIYFQVASVIWMLIEGGYLYSRFTIFAMRHSDVPYYIYLLCGWGVSLIVVICWTFVHQHRSSQSNNSFCWLPYAQGSHLWILAGTMGVAIIFNLLFLLGIVVILVQKLRAENTAESKKIWRAVKATLLLVPLLGISNIPLFYEPTKPSGAYMLGSAILQHSQRNTKCCEATVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3U2</accession>
    <name>A0A158Q3U2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pkinase_fungal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7353</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A158Q3U2"/>
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        <property type="protein sequence ID" value="DME_0000319401-mRNA-1"/>
        <property type="gene ID" value="DME_0000319401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5773944at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000319401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41850" checksum="4CC9D5C8BFD40CDA" modified="2016-06-08" version="1">MYKNEIHDIIVLRMYIFGDDDKFLQKIIAISNDLQGEKGYIIKNSDEILHRCNIIYTLTSINLDAIKKIISYTNNENILILVKEEWTKNEVERIDALIAETKASKIESLNGECNRLMNLAQCRSRDERINLLTHWIEKSDYRHYFITGNSPTIKSEISSILGQIYKFEHQPQCNLTDKPPPLHWSNFPREDELQITFKFNFPHNYFVNDDLETIINHSSESFNWSYIYKWTNGALFREKITKIGIVKHLVNILEISGRVDRAELDDEFENMPMKAVWPFLAIVLHAAISYLNGINLPYQLSILPIGDLFYTKNAIPPRSFDITQLLVSIDLFQRVSFRFNEELCDLQLQQLFNCLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4H1</accession>
    <name>A0A158Q4H1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dedicator of cytokinesis protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8713</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4H1"/>
    <dbReference type="STRING" id="318479.A0A158Q4H1"/>
    <dbReference type="WBParaSite" id="DME_0000483001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000483001-mRNA-1"/>
        <property type="gene ID" value="DME_0000483001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="447"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1682"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1704"/>
            <end position="1718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000483001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1765" mass="203757" checksum="16499C4378ECB17D" modified="2016-06-08" version="1">MEMQSNSSHKFIIINISRNFSNFHIFVIEIFSESIQYNLTNDTYATLEAVDYNFLILYIGEYVNIINSTQDWCYGNKEGDESVCGLFPRSAVFLLPDPSLWPFSREAQEIILELNETLEEWWISIKETYGKQARIGCQDDVLLFMEDLMVMRKKILSGNVPIEELKDMRLQLAKKIDLGNQWLGLDMIIRDETGRSIDLDSVSVVQIFRAHITAAEKILNDSKPSDIRVVNAFSLLVHAQSATVDCKSECEFSLSLYDSTDQKFISENFIFYWSPQIGALSNRSSKALFIDLGSKEYPSFPASTKTHRIFLCIRVSRIAPIDPSSATMKKVFDAGPPQLWSRQPYAAALLDLSDIFDRPVNDHIVPLNREDTLEQLIAKARSTNSMKISNGENSAAFGRSKLMLSTEILIGSLTEIKKSNLHIFSINPPVEVKKMYFADVISCDESRNDLYLTLLHGDFHGGKGSDKNIEARVSVVDSNGVVNNSIEICTADGTLHRSTYHSLVFYHEDKPKWNETIKIQIPDEADQNVHLRITFHFKKSYDKTKQEKGPFALAFARIMEGSTLIGDGTHELLVYKIEPGKFDINDITYTRLPATRNELKASQSQMRPQTTTFIYYEKNYIIIQTITCSTTLTHNKNLLDILQWKANRGNLKLRLEEISKSKGIMVSEEIVKFIPNFCDVLFEIMDQYSDYDELIFDSLIFVIQLVCEERYKNFRIILQKYVENFHSTIAFAKLMPLLQKRIENAEETHEWTLSTIKSLGILMQIIVKSKRCSDRLGVTQADFHQLMAEFLNAVILFLRNKRVRMTCQNTALKYLPTIFPHVCSPDIYSPQELTAFLVNILDHINGSISPRYRLNFIREIIQSNLFLEGHNRCHLLPKVLDKVLEELDDIVSQTPNIDRHKIEDCVVTCADIIFDIFDRLFRTNSQFENGSEDELCLIISKVFRSIVQTSIYLINEKIVFSTFAALLAVLLNKMSAQMYKIYVDGLHTRIDKHDFLMELLHLFRDLINRSPFSSSWFYMIYLLNKTILKTLKFIMQTIVEQFYGIEFDLDLWREYMLTMVTFSCQKSLQIGSLPTTKRSRYLSSQLDLRKIAVADLRSMWFRLSMKDKGIFIPFMVGSFLQVALIDDDVVRETVIPIFFDMLQCEFLSHPFRDFSRFANEMIIQLDCLVDEDRGDLSFKEQLKRIMLQMCSTDPELKTEGCRFVHTIDTLLKHLFEYREVRTNAYCIENGMDRTVQLLKYYDAIGQHDLYISYVYKLYDLHMLSNSKVEAAYTLLKHGETLTWEDRELSPALLSAHLNRHCGTHRQLKEALYTEVANLFDEKEMWEDAISILKEIKRLADLYHKISAQSRVGFTFYLVGFYGLDFPVYLNNQQYIYRGNECEAISSFQHRMLSTFPGTELVTSMDDCSHLSEKSGRYLQIFPVQTYCENKPQKKCANRLICWYWKNNRIENFEYCKGQFRKGTKWTELEDSEIMRSWVIRRFVKSVEPLPNILKWSLVASISEPIEYSPLMEAVRTMQRNNDELEEMAHVVFSTPLESVVPLGGKIRGIVQAFVQGGIKNYKVFFTEECKAVLNQSERELVLQLEALIKNQIPILEFSLYVHASREHQIDLQFHESLAQSFNEYKISVEERFGKIPSQLPPGCSIHISHSHKNIEERKMNNFDSSISPTVMSITGVFRRGGGLYNTKSGRNTPKKSSRGDIKSTTETSSSKRISSSSDHSMDSVFNDLNNGTPRSTLDLSRFEHSFQSPSSLSSYTGDGHSRHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5N9</accession>
    <name>A0A158Q5N9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10232</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001207">
        <property type="protein sequence ID" value="VDN60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5N9"/>
    <dbReference type="STRING" id="318479.A0A158Q5N9"/>
    <dbReference type="WBParaSite" id="DME_0000788301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000788301-mRNA-1"/>
        <property type="gene ID" value="DME_0000788301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839471at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000058">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF45">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="9"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000788301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35808" checksum="31CD186E2E60FCB2" modified="2016-06-08" version="1">MYNALNMEYYGKIGVGTPFTQFLRVAFDTGSSAIWIVDASCNVSECLQKNRFNSSLSSTFREMDEPWKMIYSDRSYATGTLGNDCIGILGENSEILKICNTTFGLGKEISGFNDDPVDGLFGLSFDTVPYNGALTPLHNAIRINLFLEPIFTVWLGNKVTIIFGGFDKENCGPIIAYEQLIAATFWLFQIRGVGIGSVNIRATYQAISDTGTSVIRGPKGIIDRLAIEIGAKYYPEADQYLINCSAFNSPPIWIIIGSNKYFIDAVNYIVEYSAGHCIFAFDGYTHMGIGNPWTLGHVFIRQFCQIYDIGNKRIGFAHHKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5X3</accession>
    <name>A0A158Q5X3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2473</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5X3"/>
    <dbReference type="STRING" id="318479.A0A158Q5X3"/>
    <dbReference type="WBParaSite" id="DME_0000849801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000849801-mRNA-1"/>
        <property type="gene ID" value="DME_0000849801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060424at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF202">
        <property type="entry name" value="HEMICENTIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041046709" evidence="5">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000849801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19796" checksum="219955B82D1038F8" modified="2016-06-08" version="1">MTVVSGCFLVLLLTVIQKTIEQRDIYDTHWDCKVSDPLSCDQTKNEVCVFKDGRYSCECPTGVSRLQDGRCIVIDECSEPRLNDCHENSRCIDQMEGYTCQCNPGFADVSEDIQKKPGRICQSEVNECLQPARYYVDCSENAACQDTPEGFTCLCRPGFTDTSAHYSLLPGRKVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q677</accession>
    <name>A0A158Q677_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10634</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001230">
        <property type="protein sequence ID" value="VDN60661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q677"/>
    <dbReference type="WBParaSite" id="DME_0000927701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000927701-mRNA-1"/>
        <property type="gene ID" value="DME_0000927701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794558at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000927701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55864" checksum="2E5DDF2363964323" modified="2016-06-08" version="1">MYDSNRISSRRVSVDKISTQMYNDCVTLLTGGVVSVNDEEYRRQLDALVDSQEYTVACDVYDEILGHMDYAVINLPTKRILLTSEQRQQVLEAVVERFKDDRHPIGSCLQFIQNNYIGFPPVIKLRNALLDCLSQIAPNAVEDASKEGGIIGSGNGFGKVASDGKGLEDGGHEMKQFRRPNVRGSRGSGSSIINLNTPIPDNQYDVLAQVLAGKMNVDDIQDWIIKEAIKTRLTGEFIAEYWDGPREFLSGGWRIRLKNSMKVVPRKSEVDEIWRQCSETMGHDSSQRQILNYLDTRYVGISTRSRLRFANKDMLLKGTRVQFPSKPRCIGSKPMQYVQIDMIEMESSEYGDRCYSMALLVTDLYSQFVFGRALADTADSSLLVRHLMDIFGAFAPPEAYRSYTNNVVIGHVMMDIEKLFKIQIKNVGQGVMCHYNLRASMYKRAEEELGSRERWVESLPFAVIEYNQRPLKGFGDVKISPFEVSSFPISKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PNJ4</accession>
    <name>A0A3P7PNJ4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PNJ4"/>
    <dbReference type="OrthoDB" id="5870102at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="469" mass="53802" checksum="51A65BC2D52AB9EB" modified="2019-02-13" version="1">MVLVFDFESLYYSLYVFTNAVIIGGPPPSYRSSTYGDESSSLSDFPNALKRRSSWLQLIENNENLQLRNAGAYPVSSYKKTTNNGFSFNFDNAIPLEQISPNNMEYSWLPPFSQRMGQQVPSLLSMRKNGNQIRFELKGGPPFRGDFISVYDFKNVAIIDSTLKNNGKNLACFLMDLNSTAMPDIASLNVAAKNSMKVKQTQGWEEAWYFVPTPYSNATSGFFNPVVPECTEVRWITLNYTILDQKGFFFQISLFNNRCTECYDFCLPEYGIEMDPIRGEKYLNILRRDCFHLFIPEWRSYVYSNEQNQLEFEKYYQNIKTNSENAQTNPAGIIYNIEGDTRTGQNFESKWISLENANRRNSFNAPVVSQEQHADNTKINSRLSPTALETVPIVQRPIEQNAPTYFSSQGRQSQEFQGQNRQVAVGDYNIKQTGNNPNEFGSRVIIMRSEQVPRPVSAQVFLFTLSFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PQV0</accession>
    <name>A0A3P7PQV0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PQV0"/>
    <dbReference type="STRING" id="318479.A0A3P7PQV0"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="158" mass="18570" checksum="3CF828F48E56E1B4" modified="2019-02-13" version="1">MHVFIFSDIFLPKATLNLNEYFSELKNFYEENKDKANLYVVYVVSGTMCSNSKKYSPSFYRRVQLVRGENLDKIKALYDSVDTCEIFCLHTKKIKSLYSIYCVDRLDDDEFIQTDPERSWITCPVAQIKRAEMLEKYAQISAESSQKSELVFFYLLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PS10</accession>
    <name>A0A3P7PS10_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS7453</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PS10"/>
    <dbReference type="STRING" id="318479.A0A3P7PS10"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="18">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="17">
        <location>
            <begin position="139"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN57480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="457" mass="53871" checksum="F364D3ADD392CACF" modified="2019-02-13" version="1">METSLLNGLYWNNMKIRWSTIYYESRLLGSPRIRMLKVNYHYETEEKSKTAAYWGRFAIYGGGGFVKYLTMDDRDASLRIITELKQNRWIGRGTRAIFIDFILYNANLNLFCIVQLIMELPATGGVFPSSALYSQRLIRYVTNYDYFVFVCEIIFCAFVIYYVIEEILELIRCRLAYFRTFWNCLDLVYLISFTVIYFDIVLFILTKKRLTNIMNQYNEENYINLDELVTAQNNFSYSVGIFLIFAWIKIMKYISFNKTMTQLSATLARSAKDIGGFSIMFFIFFFAYAQFGYLVLGTQMADYSTLFHSAFALFRTILGDFDYDALRKADRFLGPIFFFTYVFFVFFVLLNMFLAIINDSYVEVKSELVKAKNEVEMIDVRSTRKSLKFSSCKIYLGFRQGFTNEEISEAFIKYDIIDRKLELDEMQLVVEELEKKHGITQEQPKETGNFRDINMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PT13</accession>
    <name>A0A3P7PT13_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PT13"/>
    <dbReference type="STRING" id="318479.A0A3P7PT13"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="2">
        <location>
            <begin position="253"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="399" mass="44963" checksum="F954BDAC0101D208" modified="2019-02-13" version="1">MRGAIREAKTVLEMILKDDEEIRTIMDNTDAPFGQLNQEKREIFVEKNDVAMLLSQLQTLENVLDNFKNNITGRSVAKLDGQVYPGTKMIQLLEEAKIRKDFRDRIARLTDKIGQYLTHKTEQEDEAVKGVYLQLFSSFVSTVYADSYDPLKPLFEIKTPQAENAYLHRTAVTFAEKYQVLLQCENMYSLNVRSVIVTSGTLSPLDVFTNNLGITFKIKLENNHIANTSQIIGACIRADKQGTPLCGFKTKTLLYLIKEKKSNGQSVWSEMGRLKKLFEEPKSKSELKIILARYKESIKYDGGAVLFAVCRGKVSEGIDFADNESRGVVVVGIPFAPVNDARVELKKQFLAQSNAGKLSKNVSFLSFKLLLSLFLISLGFCFKLLSSSLLFLFFIAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SI90</accession>
    <name>A0A3P7SI90_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Ribonuclease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23 24">protein Drosha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">DME_LOCUS3895</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="UYYG01000211">
        <property type="protein sequence ID" value="VDN53922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SI90"/>
    <dbReference type="STRING" id="318479.A0A3P7SI90"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007506">
        <property type="term" value="P:gonadal mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000002">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="18" id="KW-0334">Gonadal differentiation</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="17 25" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="27">
        <location>
            <begin position="68"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="27">
        <location>
            <begin position="212"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="26">
        <location>
            <begin position="355"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="VDN53922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="472" mass="53984" checksum="3E37B538A916D6DB" modified="2019-02-13" version="1">MYLSFKHLNETKSVLLCYLSPVMINFYSLGGITPVLLFTTCTFSICFRTLMEIMSKLGSKRTEQSPLNHNERLEFLGDSVIEFLTTIHLFYMFPDLDEGALATYRSTMVQNKNLASLAKKIGIDDFMMYAHGPDLCHESDLRHAMANTFEAVMAAVYLDSGIDDCDRIFGEAMFQDDELRDAWFFLEEHPLKRDYPQGDRHLIQDVSALQHLTEFERSIGVTFKHIRILAKAFTRKCVGFNNLTFGHNQRLEFLGDTVLQLITTDYLYKHFPYHHEGHLSILRTCVVSNKTQSIICDDIGMANYLTLKLKDKADLVEALIGALYVDRGLGYCKIFCRVCFFPRFKLFILSQRWNDPKSQLQQRCLALRQIDGGTPDIPEYKTIGVAGPTNTRVYQVAVYFRGRRLASGCGHTLQTAQMKAAEHALKAQARLFQGTRIQSKRSDEYISGSSDPQMYIFLQIAEIGCSRSRIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SQJ9</accession>
    <name>A0A3P7SQJ9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SQJ9"/>
    <dbReference type="STRING" id="318479.A0A3P7SQJ9"/>
    <dbReference type="OrthoDB" id="5917530at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF6">
        <property type="entry name" value="STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="294" mass="32839" checksum="79A19E33B3C8A02E" modified="2019-02-13" version="1">MPNKVANNLTITFNLKALIDARCTDTILWSITSFIGILLTFLHSIPLITNSWVYVIEPRPINKTNENGDFLVLFFKSYLIIRNAEIERRCHWNPIFTGEDLTEYSSATLAIENRLAVPATMHIIGAILCYLAFFFGTIGHLKRNSQSLISAIIYICGGLIILMGVLQFVCVVDDEMAPRMKPNAAGEPSKFKFQYGDVSDKIKVIPGLAAHVRHTQMEKALLGVQMPEAMKRESEYAIFNSFSHRIPPTTAFGSISPNSSPLPFDNSLISSPPPDVSLIKYHSSFPYKHMKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SX30</accession>
    <name>A0A3P7SX30_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Troponin T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SX30"/>
    <dbReference type="STRING" id="318479.A0A3P7SX30"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46745" checksum="304E2C97A9C4E395" modified="2019-02-13" version="1">MLIRIDEEEYDEEEEEDEEEEVEEEEAESLSEHDYEKSRVNSVPKEKETDGELLNEETRIDENVPNIIHFRHRPTVQLIEKDKNEALTEAEKAMLASKKRQEEEAAAALQDYEEHRKVEREKVEQELKNLKAKQERRRQEREEEEREFAERQRLEEERHRQEEEERKAKIEADKRRKEEEKKKRQMLVGSFVGVAQTGGRSFVLPRKIGDNATNKFGNIVQAKQEMGMTKEQQEEVKRSHLESIKKTLDFAGLSLNDLKEKIKQLHQRICRLEADKYDLMKRHERQEYDLRELNERQRQVARSKAAKKGLDPDSVNSRYPPKVAVISKFERQIDRRTFSERRAVYDQKNAYPCFPNVPPPPTIYARVIPAIGSEIFKEDDDEAENEEKILEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0P0</accession>
    <name>A0A0N4U0P0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS4486</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0P0"/>
    <dbReference type="STRING" id="318479.A0A0N4U0P0"/>
    <dbReference type="WBParaSite" id="DME_0000012601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000012601-mRNA-1"/>
        <property type="gene ID" value="DME_0000012601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097475">
        <property type="term" value="P:motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097402">
        <property type="term" value="P:neuroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905485">
        <property type="term" value="P:positive regulation of motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904937">
        <property type="term" value="P:sensory neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15035">
        <property type="entry name" value="7tmF_FZD5_FZD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000016">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040937" evidence="15">
        <location>
            <begin position="18"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="16">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="224"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN54513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000012601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65260" checksum="05B4E4537FB3023B" modified="2015-12-09" version="1">MDLWFFIFLTLIPSSNGFQNCEQITIPLCKGIGYNMTRYPNSYGHEKQEEAGLEVHQFYPLVEVGCYKHLKFFLCAMYTPICQHNYEKMVMPCMEVCLEAKKRCSPLMHQYGFKWPLALNCEQLPRMSEQQITGNICAAPPDTPDPAVFDDLVNLLPHPNHRDSTPVIGIDTKEHCKCRCIRPFLQIADSRSYVANVSGCSYPCHKRCFGKLIQFSLKLFFNMVNFTAIWDIPMSGTCFLLSAFTVLTFLIETDRFQYPERPIFLLAFCQMMVSLGFMIRVVYGHEYVACDSRMVRHSDQQINSCQLVFLLIYFFGMAGSVWWVILSLTWVLAAANKWSSEAIASCANYFHFAAWILPAIQTVAVIVFGAVDGDSMSGICYVGNTNIDHLRIFVFLPLLIYFVAGVCFLCIGFFNLWRIRSLMQKHHPGGNNTSKMTQLMSKIGIFSVLYIVPAVFVLMILIYEQQYRPQWERSQLCNSETFIFLTLIKSASMLVIGWTSGVWIISKKTLQSWKRTLCCLKSSNSIHKYEPTDIIYARSDCIAPHMYNKALRHCQNYAISAVPEKYNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0W0</accession>
    <name>A0A0N4U0W0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IGFBP N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4566</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0W0"/>
    <dbReference type="WBParaSite" id="DME_0000020601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000020601-mRNA-1"/>
        <property type="gene ID" value="DME_0000020601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042202" evidence="1">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000020601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16861" checksum="D9A5638ADBCA38A2" modified="2016-06-08" version="2">MYRLLLLLLMTLPIVNSLHLACLCCIPLLQCLCPCCQCPAPSLPLLPKLHSLLPCFPKCPPPPPPPPPPPPCYPCPPPAPCPPCPPQPRPPSPPAPCPPCPPHPYPPPPYPPYYRGPQKHYQGTPGMSSGYAVGPHKGYHHLLKSAKAWYTKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U117</accession>
    <name>A0A0N4U117_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4630</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U117"/>
    <dbReference type="STRING" id="318479.A0A0N4U117"/>
    <dbReference type="WBParaSite" id="DME_0000027001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000027001-mRNA-1"/>
        <property type="gene ID" value="DME_0000027001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001223">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF171">
        <property type="entry name" value="STRETCHIN-MLCK, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="132"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="299"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000027001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45341" checksum="4D777348D253F7D7" modified="2015-12-09" version="1">MPFKRPLGERTADNQNLPNFIRPLQDKRVVVGQTVILECQVEGHPDPIIKWLKDGQNVTQCPDYEITVDGVKHRLIIKNVQAPDSGRFTAQAMNAVGTKQSTCTLIVAPAPTPIPGVKSVASPGPPQTPVGPSLPIFLKQLNHQPLKPGAQVVLEARVVGNPTPQVEWLKNKSPLKNYRARTEYDPHSGICALIIPQMFADDIGEYTCRAINSNGIGETSLLPRDEYEKWLHEEQSLITKERKKNMLHSFGRSVPTTQRQLQRRTPNGSSDPDSSPWGISESETEPELAAIDLHKICTPPVIQSPLRGLRLTEGTDAILQCTVIGYPKPRITWLKNRILLNPNISQRISMMFKGSTALLKIAMVSVEDSGEYMLIAENNFGQVSFIKNNFKKNYFIYFFFSFFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U129</accession>
    <name>A0A0N4U129_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELYS-bb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4644</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U129"/>
    <dbReference type="STRING" id="318479.A0A0N4U129"/>
    <dbReference type="WBParaSite" id="DME_0000028401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000028401-mRNA-1"/>
        <property type="gene ID" value="DME_0000028401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="2">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000028401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1458" mass="167246" checksum="BB35724DBDA0D20D" modified="2016-06-08" version="2">MGNQANEKIERRSVLLKSEKVRNCRSVLKGRYLTLKGEYTTLYYIADGQSVSFWRHNITAPIAVYNFDNLGKDSQLVDISYLPFKDGSDGVAIAINYSSEKMLSFVIYYSIARAKIITKLQIPHQITCISTIFDNMSQYKIRDLHPVFHNSPHLIAVGTKNGCCFLVHLGFDLPLVEHDQDAHKVSGQMEAKRLGRIHHLPLEEISVTSVVYIEKCKLIMIGFSFGGFLMANISSEHRSDIYWFSESSVFAFAYQEAADDPRPFIFLWIAHSSCRHNKMVGSPHVILAIVHFPKDEKLEPNDRSYLNPVLHYHLTWFPNESFTAWLSFRTILQKESTISKNSSGIENKSRESSQGLYDNDDTSLLLMSWKSGKKGIVRGVVFDLNAFYYKRLVNEVFYDSTIAHQNAFLSRFVLWKSNDLHEGSPFDIMVSPNSIHRYESPWKDSSDVLHYCSVISFDICTFTETNECYLNIPSIQQELLNFIELNLEVCLGKNRKYIALWISAVGLVNPFRVVSDLSEADFINILSALLYHGLIVSIKNWINYSKEHDLLNLFGKCLWEEIEDAKSRLDELVKPIFDRTSFDFSKNGLSWMRSISRLFFNACSLYTDLLEKSSDRYEIASLAHKRMASRNLYLYSKLLLFFLDYKLIPEKESTISIYKKMQEFAAERSLDLSSSYRVWLRSLLLRIDDESSSCSDDMLTQWLPSHTLLDLASYMLLMKLNDAMKYKLVGYYLLDYGYCSEKSNELYNQFARLFFNENIALKNEIYSEWKMDNGQQVIKKETIQHEQPFIDRKLCVDSKNIKVIRDEILEQEDGKTLWNQYCILNKYFDLLLMPEKIANDSGWRRKCDAWTTCIISNMPKCLRSSFTERSMKDQNNSDEQVARSTSQSLRDYCSEICESPLNDQRDSPLVSTDIQIDDEVDESLVQPFDTVPCGENHSTLFEKLLSKEKLDNVQRLLTPTSASRAGGDSSRALYSPRSPPHSILKSAKKKMNPGYTYKKIDATLNIARRLRFELANREKPISNSDLKLRPNVATFSVEHETTSRSEQISFDHITECCDSIDNILYFMVEFSSILGSFKDLDHSFDVNEGRFKQREKPSEGLILRSYEEQEEPLDDQTQLEEEVYVQKQIKKTQEKYSGNYSTPSIYGDTVVERSLEEQDELDFLTEGDYGHIVGPAGDGFQISNITAAKNVAFISEVSKFSEDIYSPSKANMFEGNLQKTRDSNVSGIQSAIEYQSDPEAEAFEEDKSILKNLQNSQFFSETVEPLRRSQRLRNLSESSKSGTADFLVYRKELFKKDDCSSVNIGKRASSMPRNVSAGSDNTVEITTFRRASSVPSVPCSKRKKLDTSSFIKVEAKLPTDHKRHRACNRKSATTTRKTKGKSTLDVHSPSDETPKTKRVKNQLAANKESARTPRSKKKQLKPENLIESSTAGQRFSKRIRAGRKTVEDIIIKKQPLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1Y1</accession>
    <name>A0A0N4U1Y1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5006</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1Y1"/>
    <dbReference type="STRING" id="318479.A0A0N4U1Y1"/>
    <dbReference type="WBParaSite" id="DME_0000064601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000064601-mRNA-1"/>
        <property type="gene ID" value="DME_0000064601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919692at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15533">
        <property type="entry name" value="PHD1_PHF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000064601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="594" mass="67385" checksum="47060015931F15FF" modified="2015-12-09" version="1">MVSGGEKSILEKIEALIAPPSGRVKKLPPWKPPSRWKSLNSQHCSSCKEGGELLCCDRCPASFHLMCHQPPIDKKDIPSGKWLCNRCHYEVMDKTASYKRDASLNESARNDAALSRLIESCGSKHPLAVLADAALVLNAQRFSLPPNIDSDNFQLPYDEAQPNHWVPSIKSVCHICCTSKDSCPLIQCDFCPLLYHLDCLTPPLTVPPKDKWMCSAHLENFIDRKLLSSLSLSERKYLWKKYARQPVDEYIVKMTFLKKISDEHRERGTSSPSDITEGRLVVPRAVKELYEKRWRSYRNPDHPTLADQEEWVESILRMHKNVKQICEQLKCGVAKSCTSKVVDKLEFEQNANSEIDSTKSDQRSFGKIQNVNSEEITYESDKWLSQTLPGNAFYISRFFDSAVNDPIKVKLKRIRDRCIDLLSDATKNKDDCVIAAFALQRIDELIKSNFYEMSRPKKLKFDECTFRSRYPVLAVLKGDKVDAIPIQKTSVTMGNSSECDIDLQRFPSSCTGILSYHANLMFDRATQKFELILKHGALARVDGIYYSINGRPAPNPCILCAADMQEMMRGSVALRHGSIIDIGCCRLIFASFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U287</accession>
    <name>A0A0N4U287_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PHD finger protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5134</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U287"/>
    <dbReference type="STRING" id="318479.A0A0N4U287"/>
    <dbReference type="WBParaSite" id="DME_0000077401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000077401-mRNA-1"/>
        <property type="gene ID" value="DME_0000077401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000077401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15377" checksum="F0A9EAE682D63571" modified="2015-12-09" version="1">MKDQKEAQCSICGVENEDPLLSCSSCCLSMHPDCVDLPKRVIDVALGYDWNCIECKKCIICSKPDDEDSMLFCDRCDRGFHTFCVGLTSTPKGSWICTVYCSDYAVNENLKNTLDECIARHKSTRKKSINCGDNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2N5</accession>
    <name>A0A0N4U2N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS5315</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2N5"/>
    <dbReference type="STRING" id="318479.A0A0N4U2N5"/>
    <dbReference type="WBParaSite" id="DME_0000095501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000095501-mRNA-1"/>
        <property type="gene ID" value="DME_0000095501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN55342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000095501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23266" checksum="E1FA14FD1C5D31F2" modified="2015-12-09" version="1">MVEEFAANGDLLKKIKSIERIDENESRFLFRQLTEALMYLQSIRVVHRDIKCENIFLDSHDNVKLGDFGFSRMMRLNDKSNTFCGSRAYAAPEVLSSKPYSGFTVDLWSAGIVLYIMVTGLMPYDDRNLKKMLEKQLRHRVTFPKTVELSSEVKHLISEILHPYPTQRKAYPEIIRSSWLINTPYRIRTKLDDLSNTNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2S7</accession>
    <name>A0A0N4U2S7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS5362</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2S7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2S7"/>
    <dbReference type="WBParaSite" id="DME_0000100201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000100201-mRNA-1"/>
        <property type="gene ID" value="DME_0000100201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5974730at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDN55389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="DME_0000100201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="54023" checksum="18055C0BFF245EB1" modified="2015-12-09" version="1">MGLIDSLSTAFNAREDGLRLIIAILAGYPLAVIHRTFLFKAPRNVQHVFFVLTGLMLYWFNYGFATVHSIIATINAYIITNYFAGTTLSVILAHLAFLGHLLFGYWMVETDQYDITWTTPFCIMTLRFTGLVMDVYDGKKSKDKIKGSQSKTAISDPPDLLEIAAFGFIFCGTFVGHLFPFSKFRSFVNGEFLNEKGEVRTSSLMPSLGRFLGGCLYAVIHLWGNYWIPCDYFNSYEFLNLPFFWKLVWTVLWFRLIMSRYIFCWLINEGAAILSGIAYNGKDEYGEDRWDGTRDINILKWEFGLDFQSAIESFNLGTNAFAKNHIFKRLQWMGNKVYSHALTLVYLAIWHGYHLGYFLLFWLEFACVMAQRQLYDLVDKIPSLRNLIAQSWMRPVKFILGRLIINISMSIGFFSFGLVKTRLWIRPLSSMYFLPHIFYSFIWPLFYFLVNKMMKQKVEHKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3G2</accession>
    <name>A0A0N4U3G2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated kinase regulator 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5627</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3G2"/>
    <dbReference type="WBParaSite" id="DME_0000126701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000126701-mRNA-1"/>
        <property type="gene ID" value="DME_0000126701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799576at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000126701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40355" checksum="4DB1DDD4F7B6A3BA" modified="2015-12-09" version="1">MSWQENCQRAKLSGSKQNLSVDWPSPISILDSPERKRAMLSKSFADSGLGSTIFGTPPDKIHMKVNDVPPLRTPTKRRNSSGSGSGLALSPRSFIHVSPYSSSFSSIVQPSHDYTKSKLCDPKKAIGFRFSESTMEDRLEPTDLTAPEFIARSEPIAIIDENVPNTSRFYKQCFENFSHSQNIKEDSGFIDTSHFSLESSSNNPEVRFEDFLSSTLREDRLFFGHEGFVGDFYSIPEQASGPLESILSDVNRFPNIILPLSPSKAANVLTTESRSPRKAVPQQQKECVSYVSPCLPNNSSGTQKKSENLDKTFTEFVPPKKEPNPYSPSWYAIVCGGTPCQLDMMRKARDFLESLNKREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4A3</accession>
    <name>A0A0N4U4A3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5960</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN55987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4A3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4A3"/>
    <dbReference type="WBParaSite" id="DME_0000160001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000160001-mRNA-1"/>
        <property type="gene ID" value="DME_0000160001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000160001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40135" checksum="24571E7BB0844706" modified="2015-12-09" version="1">MSMDADSQFNNSREGSCDKNQYDVENKLPDTNCLIKGRQFSFAVGRQIARGRMGAVYEVLRRSDGRCFAAKLEVCDAHFHGINMDYTILSQATKANCKHITKLIDRGKIEGHFKFIVMSLLGDNLHKLRLTFVERHFSLSTALRLGIQTLAALNELHTLGFVHRDVKASNYALNGDRGPIVVYLIDFGLCRAYRNSEKEIKPARDKAQFRQVIWIYINDLYVEKNSKLGTTRYASVNAHNEMDLSPRDDLESWFYMLIEMICGFLPWSDLHKNERSEVKKMKEESRTHDGIQVLLKGCPKTEFRRILQYIDGLVYHSQPDYNFLTQLLQLAMKNNGLKMDDPYDWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4N8</accession>
    <name>A0A0N4U4N8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6118</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4N8"/>
    <dbReference type="WBParaSite" id="DME_0000175801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000175801-mRNA-1"/>
        <property type="gene ID" value="DME_0000175801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000175801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9155" checksum="E9EA36F4565518AD" modified="2015-12-09" version="1">METIVDDIILEVNKSMDGNKVESNILGENIAPLLSSPFESLPSAQNACRDLRRDCYSYIHLCNSTDYGEYIRNSCNLSCGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4X5</accession>
    <name>A0A0N4U4X5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6227</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4X5"/>
    <dbReference type="WBParaSite" id="DME_0000186701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000186701-mRNA-1"/>
        <property type="gene ID" value="DME_0000186701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805447at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000186701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38496" checksum="721F958A7B3C8750" modified="2015-12-09" version="1">MRTETERPSLEFTCRFDNCLRREQILQQKIPTMSLFSCASLNDFGKVDYEYKCPAETKNFDYNPCNPHNRNQCPAGFACRPCQLFTNDHLTNQISYICCDSSKMTINDWFIELGISPQIIPQTPHSQLESVTISDFAFNVPSPSIKTGDEIEVSDHPDYVTGNVKTLTFKSMVPAPGGYLHVLLLVDPVKRAKALFFSYDYPATGESVLNIDITDQNRRGFIGIVSNYSLPQQKIYRHQYVVLVYKTTDSLEEKVNISGDIRGNFENLSDFLTISPTGQMLGRPIAGTFFYLTSKRTMFRVEAEKIYRMDDSGQSRSSFILVSIITAFIIVYINLFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5H1</accession>
    <name>A0A0N4U5H1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6456</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5H1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5H1"/>
    <dbReference type="WBParaSite" id="DME_0000209601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000209601-mRNA-1"/>
        <property type="gene ID" value="DME_0000209601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000209601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32161" checksum="94519087129A159D" modified="2015-12-09" version="1">MKAIQCHKNCFNCFQEFDRTKELNGATKKATIKKIPTSSKKVAKDLCPNTKISLKERSQILATHNKFRSELAAGRVRTKDNIMPQGADIRKLKWDCELERTAQKWAELCQWRHSDESFRNHKGENLYKVNQNFPVNRIREAMQKNFIAGHMKRAAQAWWDEMAWFETYKIGCGMKTDCIDYSNPLLKHMLYVVCHYDPRGNTLNEPIYEVGKPCSKCKRYPRSKCEKNLCAGGGPAVYCKDYYGNCEKRYCSYTFDARFAEDMKKHCNKTCGYCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U608</accession>
    <name>A0A0N4U608_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6683</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U608"/>
    <dbReference type="STRING" id="318479.A0A0N4U608"/>
    <dbReference type="WBParaSite" id="DME_0000232301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000232301-mRNA-1"/>
        <property type="gene ID" value="DME_0000232301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067827at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF10">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000232301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10390" checksum="65B5EDDCA1FB112F" modified="2015-12-09" version="1">MHDVAAIELRKLSKAERRKRRRATPKYRNLHASRERRYSIRVESFNHAFAKLRALLPTLPLNKKLSKIEILRLSILYISYLDNLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U628</accession>
    <name>A0A0N4U628_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6708</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U628"/>
    <dbReference type="STRING" id="318479.A0A0N4U628"/>
    <dbReference type="WBParaSite" id="DME_0000234801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000234801-mRNA-1"/>
        <property type="gene ID" value="DME_0000234801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF24">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229770" evidence="8">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000234801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51185" checksum="C43F9D6902894D49" modified="2016-06-08" version="2">MSYLLFRYFILLLIIFKVTSAVTIDNEIIGDPDIECLDEQIRIFITTKKIFAGRIYAKGKADNPDCSRDDYAPQRTRKPHMVLRFGTCGMKSLRSVDPRGMYYGITLVVSFHTMFITKVDQAFHVKCFFEEASRGLTVELGVSMIATTEVEARHSIPGCIYSIHSSSVGEIDSGRPAGKPIRFARIGDRILHQWHCDDQMFGVLINNCYVTDGFGKRADVVDSKGCSIDPILMTRIRYSPDLQRAYAESQVFKFADKPGVWFFCQIQMCMKKAGMCEGVTVNGNSQIRIKNNFNDPSLIFEVDEHYEPQRRSKMPRILSTDAFENGLNFQFHPNFPFNLKISDSDLTLPPNLSDLLANLPDDINADSLQKMFRDSVESRRTLLQNFDFLMNGISWNSNRMADIPLDEKVPVEQNVSPMIGGQLIIYDIDEEPPKSSLKRSDNGLFFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6C0</accession>
    <name>A0A0N4U6C0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ras-like GTP-binding protein Rho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6820</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6C0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6C0"/>
    <dbReference type="WBParaSite" id="DME_0000246001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000246001-mRNA-1"/>
        <property type="gene ID" value="DME_0000246001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000246001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21660" checksum="9AA3F05B56FAE5FC" modified="2015-12-09" version="1">MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVRHFCPNVPIILVGNKKDLRNDPQTIRELAKMKQEPVRPEQGRTIAEQIGAFAYLECSAKAKDGIREVFEKATQAALQQKKKKKSKCDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Z2</accession>
    <name>A0A0N4U6Z2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IlGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7087</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Z2"/>
    <dbReference type="WBParaSite" id="DME_0000272701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000272701-mRNA-1"/>
        <property type="gene ID" value="DME_0000272701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000272701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8633" checksum="986ED7C92B63F3C0" modified="2015-12-09" version="1">MIISMGIKIVCTPAGRTHPCFQGGQPNRSPVFELKGNNNRYTRHYQRGVATTCCFYGDCTLQYLRTFCCHIDYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U727</accession>
    <name>A0A0N4U727_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7130</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U727"/>
    <dbReference type="STRING" id="318479.A0A0N4U727"/>
    <dbReference type="WBParaSite" id="DME_0000277001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000277001-mRNA-1"/>
        <property type="gene ID" value="DME_0000277001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876058at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000277001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="55031" checksum="7F3642A254997C06" modified="2015-12-09" version="1">MVISLLELDIVTDLKIMKFLNDRLIEKIYNLYALLPFTVHIKTKLPRPPIFLPPKNVYNSNKTEEKICYQLHILVLIYIELFTQSNMLISSIDKLCSYFLGACTLDELNNGRQLNVNSGDLSLLNFIQLILVILRWVNEATPDDIQHLSSMFDYFRKFRSAFPNTGEFNERNRLRWKKYLFEKIMSENICATARFISNCWTSFFCPLPNERLVDLKLALQCEYFVSSEELPKPKPACMVSSKKENLISKYTNHPKPSSLLFMLEKKENTNKIGETNVLRKFKTETNLAKQFEISENQAMHSLKFTNSFFQSNQKCENTMNHNHDDREQKNFLNTEMASNRSLILINDEINSLDSTREPQKPNIERLQLELLSPEPLIKARKTKTKTMDSSSFRSSSSPDTGYSDSFPTWLRLLPSEETDHLLQLPSNCHRNTEGDECCTHNEAILEKRQIYRGTKKMDQKFQLITVIRKAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U779</accession>
    <name>A0A0N4U779_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS57</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U779"/>
    <dbReference type="STRING" id="318479.A0A0N4U779"/>
    <dbReference type="WBParaSite" id="DME_0000282801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000282801-mRNA-1"/>
        <property type="gene ID" value="DME_0000282801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7976202at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="720"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000282801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="116902" checksum="42BC25EE35B0AA87" modified="2016-06-08" version="2">MMHLRSYYLVVSSILDYGKDERIGYEPQQLLDYLQKVTGFDENEHSALVEKLDRSLQVLVCLPGWMDRFCTTEPKIKADLYGSLVTSRGTNSGIGCSMQCKLKIFAEEKKNLGKNYSQNQSITGDHKRRKHSDVRKFLSPNKILRRHKSDSFLKRIHYYGSADENDSSNESNPDSVTNNAEGFEAVSTNLNSDELAGDLLDFTKTILEADANLHSEQNHDEYNGCLKDISDALLHRMVRFVKNSQMLRHVMILMVLLEWDHSTITLNSRAISKAMAELCKYNKSSLPLNRSLLNRLELSLKNHIRILASECSLQFFPPTDHSAELSTFGRKIELVYRLFRLELWQNFTEFSLIDEFLGILKSLIRRDIMNWLSECEMNFPSSMRNFLNSLIKFSDYYVKMFGSCGISYIFVIFSAIDGIKLSSHKCDEMEEFSKITMKLYEDFKNLAEIGKESRFIAEICAWTKCLPLQMFHEVDETSYFRIKNAELYQYEQWFTSCIIYWTYTWRSLSVRYVSLAMEEDKSSVIKADEKVLPSAVNFIAIHKALYEDFIHLDLTNLSSIIICIYKIISALLSVNSIIHLKKFIVKKLNELLTIPLTVKKVPNDEYISLSIFIQHTLHFSTKGWLISKRRTERAEHLFGYIEQISSLTNTFLLAELNKDVNRQLFFIIEDYFDKNLRRGENTEYYKEIEVIIGILCRFLQLRSDDVNQNFSKRLHLNRLSSENLIFSYYCQLADITQNITNIDVKNALNLNLIIGDNNKSMDCFCQIELLPEFLFPKMKYCKQQTHIVYNNKNPKWEKEFILNRNTAEMRQIFAICWNTAHFCHALGKYTADFRHMLEHGTFLSCTGQIYGRFSPYAGQEHGTFLSCTGRIYGRFSPYAGQEHGTFLSCTGKICGRTIDDELFFTNGSVLRFTVFRNNSPKVQEIIGEAHILLPTIPRTGTSSTNLPLLSIPLMSVSCKKLLEPFQVLMDRSRNDQTAKELCKYENFAKNTWCDYISIRRKESKLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7D3</accession>
    <name>A0A0N4U7D3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS121</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7D3"/>
    <dbReference type="STRING" id="318479.A0A0N4U7D3"/>
    <dbReference type="WBParaSite" id="DME_0000289201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000289201-mRNA-1"/>
        <property type="gene ID" value="DME_0000289201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="42382at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000289201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21453" checksum="5C04E25EBCE87B76" modified="2015-12-09" version="1">MEPMFSIHKMVCHHFIKVHKVICGSIACQSDQIKKGDKVFFIQDQSTKTMSPCEARLLIKQPSETVKFILGRDRNKANEENKTTRKLLSTVSIDPESFKYSEQSEDINLFKGSLGIGLSLDGGRGCVYGDRPIVVKRIFEGGSAAKSGRVKVGDRIDAIEGISTISMSYLEATKTLRSRPEGPLTITIRSRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7K0</accession>
    <name>A0A0N4U7K0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome assembly chaperone 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS193</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7K0"/>
    <dbReference type="STRING" id="318479.A0A0N4U7K0"/>
    <dbReference type="WBParaSite" id="DME_0000296401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000296401-mRNA-1"/>
        <property type="gene ID" value="DME_0000296401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826198at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000296401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15942" checksum="0CD7A30CABDDE00B" modified="2015-12-09" version="1">MDCVKFPIVKDLSFEYLNSEVKFIIIEFENTDLIFLSNISKIGQILQVTFPHHLIASKLHSTHNIEFDTKILLGAYSDDFELLINRLVKTIVKFNRRRRDFFLAIGFGEDQSDLNDYFRIIIEQYQNHFQSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U814</accession>
    <name>A0A0N4U814_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CLASP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7318</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U814"/>
    <dbReference type="STRING" id="318479.A0A0N4U814"/>
    <dbReference type="WBParaSite" id="DME_0000315901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000315901-mRNA-1"/>
        <property type="gene ID" value="DME_0000315901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="71"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="788"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000315901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114881" checksum="762D7BA4281945B3" modified="2015-12-09" version="1">MLASRRGPVSEEQENANSSIPGWQRASSVPAHKRPVVVSTRNAGTAGSVNDEAFQKAFLEVPKCDIYSAKQLREKFDEMCRILENTDIDWSKRMNALKTLRAIIIGGGLDYSDFTEELRDLEVALSNSIKDLRSQVCREGCVTVAFYCERLETRMVNLVDSLMPTLIGLLQNSAKVMATSGQVALKYIVRYVRSQKLLPHLHTAMSSKSKDIRRFVAVLIMMALSTWDNRLIEKNMAIFIDCIKMSVNDPDSETRTIGRDMFMQLDPDYKQQLYKTLDPSKQRALSGYLSQSSSSQSIISERDSLPVSHRSAAYALHKTSPSYYTGRSTSDIDPGAARRATSRSRVPPKWGVPPLQQVNGSNSAAPVRIPTSQRLASDSRIIPTLRRGITTAPPVNVTSTNNFARSQPDSILAGSRSTSPSPKVPSSRLPPRTIGSSNRLRHQTEDLDDRASVSTTLNFHLFIEIMKNFNFRFETVELTTALSCCSSSSISEKKDGLKALSAILLSEKQISSPDLKKIADRLNVLIGESSHKLLQPLTDVVITFVRLYHHDLGDWLNQLIPKLVTKYSNDVLLSNQEKFSMMLDAVRQNFNPEKQLNAVCKFIQDPIRNNVTFKVKYGLLDYLHKLMQSMEVWKSMNQSEVRQAINKIFQWANDPKNSGLMTLSEKIISDMFHLNASDFTSMIATYPNDLKDRLQAIVRKNNLPSCNMNGSFNISNDTRADILETTAQINEFVDQRNVLPSCVLRSHYQQSTPRRDSTESGGMQRANREDANGNLSGYILDAQGFAADLAQQEELITKIGEELSLHNKRNSERMRAMAVLSQITRDNLFSLWDKHFKMIFLLLIETLKDNDPDIRRMALKLLKEIWCYSQAPRFNHFAEMALIRVLDACTDEAKFVVSAAEDCGNVLATHVSSATCRRVLLAVIKSDVGEAKILVAIKMLTKVIESLSVEELQSVLNEIAPPIVDTYNYENSSIRKESVICLVAMILIVGEESMAPYLAKLNKGKQKLIDVYVQRMKKPTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8G1</accession>
    <name>A0A0N4U8G1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7489</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8G1"/>
    <dbReference type="STRING" id="318479.A0A0N4U8G1"/>
    <dbReference type="WBParaSite" id="DME_0000333001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000333001-mRNA-1"/>
        <property type="gene ID" value="DME_0000333001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10591558at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000333001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19113" checksum="EB80BE2ADB141285" modified="2015-12-09" version="1">MSKNNIKITTEIEQNSIYPARSVKPNDLSHLQHCVAYNIVVSTLLQQKNLNNLKTEATVEQIATDVLSCLLERMRMDGLISRTRLCNDEDVTVAWTCQTSVSHYFRHFFNHRFHQEIVEQMDQVYHNIDSGEKIEEDSAGAAAAYASCFYKNVSNSFMLFAKTSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8R8</accession>
    <name>A0A0N4U8R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8R8"/>
    <dbReference type="WBParaSite" id="DME_0000345401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000345401-mRNA-1"/>
        <property type="gene ID" value="DME_0000345401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000345401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11846" checksum="D14A8508C0D37CA8" modified="2015-12-09" version="1">MDSEPYHYAVSFKRSGRKLPSTPILPTRSVSESPSKYRRQSALPAYMFHPQDDYDPCKDCQLTLDRRRCNERERIANFYDQISTRIMHDERLSIFAIGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8T8</accession>
    <name>A0A0N4U8T8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS341</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8T8"/>
    <dbReference type="STRING" id="318479.A0A0N4U8T8"/>
    <dbReference type="WBParaSite" id="DME_0000347501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000347501-mRNA-1"/>
        <property type="gene ID" value="DME_0000347501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="7">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN50368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000347501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34249" checksum="8A7EC314EC54D39C" modified="2015-12-09" version="1">MEYDIASFHVNSFNYLLDEGINLAISDIPAEKLRLANGDAVEIRYCGATVGYPTLKDDLIVPCNDDLKLFPAECRQRELTYKAPIELPIMLKSNRCHLNGLSREQLIKHGEEGNEKGGYFICKGTEKVIRLLVASRRNYPIALIRRNFRDKGDLFTQYGVLMKCIRQNHSATIMTLHYLENGTITIAIQFRNELFYLPLMYIIKALVMQSDQSIYQHFIRGRAKDLFWAGCVSSMLLCCQEDGIRDQESALIALGSRFRVTLEDRIGSWETDQQVMKCLSTFVADMSAKATFCDGTVNASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA82</accession>
    <name>A0A0N4UA82_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CHCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS403</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA82"/>
    <dbReference type="STRING" id="318479.A0A0N4UA82"/>
    <dbReference type="WBParaSite" id="DME_0000403901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000403901-mRNA-1"/>
        <property type="gene ID" value="DME_0000403901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000403901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="14867" checksum="33FB78CCFD0BF3D4" modified="2015-12-09" version="1">MPRRRVASPKPSAPVRSAGRQPNATTQSPSAYAAASPQPTRTAIPATVPPATPTSNGPGLFGQMAATAGGVAIGSAVGHAVGNMLTGSGGCSNEAVTPPSAPASAPATQPCEFEWKQFIECTQNQADLSLCEAYNNLFKQCRSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAE9</accession>
    <name>A0A0N4UAE9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8005</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAE9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAE9"/>
    <dbReference type="WBParaSite" id="DME_0000412201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000412201-mRNA-1"/>
        <property type="gene ID" value="DME_0000412201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="577"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="581"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000412201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="936" mass="110758" checksum="8D7E047FA0BBD468" modified="2016-06-08" version="2">MQLRRESAVHCVYKASSIVHQPNIGGLLMCFHYEWKRGMPQYFDDEIPYFGRKSSKDLKIYRNSKQRIAPDCVMKCMQDVGTGFGEYFTSDGALNTNFLQSDDRFKKPLLTASKLFFDRFHIPYSIKKKKNWELVDETKRNITSIQDDRLSIMVVKINSICLYQSERFDNTLDYVPVDEIHLVDSRNREIHKKTKNLFYGEIFYPHKFIRENAPPNIWYKKFIKKNHPPRPIINLWHSFSLYKIILVLKELVSKYSNRWLNMDKKWIAKYKDNQKNAVERRERKDRYSRRNMKYKDNKKNRMKKKGKDCQSHRNKKFFTSKCQEYANELYNEEIQPLEREISEVLPTSCRSQFYISDFLVGIPIDRLSKSNSKSKRQRNGKISKIRSEEFEQWFASSPAYELHKENDIVDESQVTDSKEKNVFSYESLPLYNIFLNQREAEFIKRQLLPNTQPVLNVIPICYITDFNWQNNTHLVLPEFLENFYGSIIIQPILYARNNEFLRIILNAFVSKYDKFNESEDKSSLLVPRSSFEKFLPRTVQLPSYDSSSVCCVFLQEMFPNKYEDQQDELCSSTSYDVDSYCSICGENDKYGFALQCKHYFCADCWGQYSVERISLARVPVLCPKTFCNEKLSLGQMRIFLSNKICQWYKNLLFNRGMMRREWTYCRKCSKILHIPESSKMEKTCGICKCGSSVCLLCEREVHIPLSCNEYEPYANVVTANGKGNEYFAENNLLQLNVDNVSVAKCPNCGAFCERNGGCEHIMCICNFDFCYQCGDAWSNQPHYMCKTKLEKVNLYDVPIEINDKIPLHVVEECFKYRRSDKISLLTRRLFKIFRSDYNMFFDVRSTFFAVTSFMEMLLLKIHYTKSYLKMWRKRNKADNKVNSSSIKLRILLKSKNRLRFSFNLFCTAIDAQNRMRIIRSKMLLDNTLQACISEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB49</accession>
    <name>A0A0N4UB49_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8293</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB49"/>
    <dbReference type="STRING" id="318479.A0A0N4UB49"/>
    <dbReference type="WBParaSite" id="DME_0000441001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000441001-mRNA-1"/>
        <property type="gene ID" value="DME_0000441001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000441001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16456" checksum="2C55B2697A4EC08A" modified="2015-12-09" version="1">MLIQRIVSTIGIISRRKTESGSRTLISELEYHKEADKLLEKLNDYLDSFPDKFSCDDYFDINYSMGVLTAKISSSIGVYIINKQTPSRQIWLSSPISGPKRFDFINRKWIYPRENICIDSLLNQEFRKIFNTDEIDFTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBT5</accession>
    <name>A0A0N4UBT5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Photoreceptor-specific nuclear receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS8571</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBT5"/>
    <dbReference type="STRING" id="318479.A0A0N4UBT5"/>
    <dbReference type="WBParaSite" id="DME_0000468801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000468801-mRNA-1"/>
        <property type="gene ID" value="DME_0000468801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000120">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="135"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="279"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN58598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000468801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48197" checksum="CD7B1BFE8D9A4682" modified="2015-12-09" version="1">MPNLAGGPLLPYPPAPPSIFIPSNLIPSSYIPSFAAAAAMSAAMSAVTHRQIQRTVSPVATKTDSTTISVNSFLSLSSPQNHACSSPPLSCAVCGDVSSGKHYGMCHFQYIAASKKFKGYFCDSIFQSLRIESPINNIPLCLYGNKKCNEAYTRREFEGKIFEGILACNGCSGFFKRSVRRRLIYRCQAGTGLCIVDKAHRNQCQACRLKKCLNKGMNKDAVQNERQPRNAATIRSCINPEFHNSSIFFSQLSYRFECIDKVTTITAGETPDSTSGTAKSISPEERAKSNEKEESNIEEIKGLENETVHETAARLLFMAIKWAKNLPSFTLLSFRDQIILLEEGWCDLFLLSIYQWSLPMDKCPLLSNLIPLSTNGLRYLQDVFMRIRKYDVDQTEFACLKAIVLFRPGKYTSQLLMGNLNRLFIATSRITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC27</accession>
    <name>A0A0N4UC27_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8679</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC27"/>
    <dbReference type="STRING" id="318479.A0A0N4UC27"/>
    <dbReference type="WBParaSite" id="DME_0000479601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000479601-mRNA-1"/>
        <property type="gene ID" value="DME_0000479601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874015at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000479601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17079" checksum="D6EABE8DE86F8F33" modified="2015-12-09" version="1">MKKPVIHALVWMNFGALCISDLIIPQIFKFLYDHEKICGDIFFDSNWLPSHKACKINCQITRELCMRKIEAIDIEEKCQKLPEICSMQLEVFLRENFVEKSTFNENLVTHAYARENFETLPQISFNATFYDRNTVSKSTMQHQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC61</accession>
    <name>A0A0N4UC61_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS8723</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC61"/>
    <dbReference type="STRING" id="318479.A0A0N4UC61"/>
    <dbReference type="WBParaSite" id="DME_0000484001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000484001-mRNA-1"/>
        <property type="gene ID" value="DME_0000484001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN58750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000484001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12317" checksum="B3118CF2DD3AA274" modified="2015-12-09" version="1">MSYRGGANGNSGLKMTESGDSFIERQNDSLVEQLSGKVAALKRITIAIGDDVREQNRLLNDMDGEFDSSKGLLSSTMLKLNRVAKSGGRSILCYLILFSLFVFFVIYYLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCT9</accession>
    <name>A0A0N4UCT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS8902</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCT9"/>
    <dbReference type="STRING" id="318479.A0A0N4UCT9"/>
    <dbReference type="WBParaSite" id="DME_0000510301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000510301-mRNA-1"/>
        <property type="gene ID" value="DME_0000510301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN58929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000510301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="77304" checksum="669B0EFFB42B2DEB" modified="2015-12-09" version="1">MTNSNQDISVKLINKGIFRRFILRKTADSDLFSELLKKVQMFDPEFSGHLAWQDSDGDLILFSSEEELLHAIRIQSCDVFRIVTVDQNGRILERENGTTNKRSKIGEDYQKDKRAKTGEDYQKISETEGINLLIICDYCDRSIDGILYECVICSDFHLCGNCEKRGSHGNHPLIRYANLNTPRIGKFMKSLINEKNYQCLNNHSSAIKCVDIFEKFYIDKHKKKSTQKIKKCPLTKICADEFNKTINNQKNLEKKNNENSTEQIRLKMGECWKRKHRLNGSVQKTSRNIKAKANSNSMNSVGVVESLDGIKSDLKKIADETAQKLTSESTDAMKQAAWQAASSSSEILKQAASAAAQQAAIAASALHQELVNLTETNENFSPLISTTFANGMDYLMEVGNQIQQALINFGIDVDIDIEHNGVTERIKQSEVKEGVKNDKNTCTDQEVLEDNGDDAVNDSNGDQKDLETRLNDIHISSHDNSTDEQLENAVDQNSSFDSDEQWTVLDQKCIDADKGELLNTSQSLCSFYPDISSQKISEDQNDLVARVNFSQIPFKDSFDGSKSPIVPLQTDEQWIDMANSSEMRNNSMFGVESVEVWQSDANSNAVGNICMAGTPFFHPSDPHSYRGELLIADKNVRSCIDQLEVMGFDNCNGWLTKLAIEFNGDIDKVIEEASKDPIYVSRIESTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD26</accession>
    <name>A0A0N4UD26_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Titin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9004</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD26"/>
    <dbReference type="STRING" id="318479.A0A0N4UD26"/>
    <dbReference type="WBParaSite" id="DME_0000520501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000520501-mRNA-1"/>
        <property type="gene ID" value="DME_0000520501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876619at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045909">
        <property type="entry name" value="MID49/MID51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16451:SF7">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16451">
        <property type="entry name" value="MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1893"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1936"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2089"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1893"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1985"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2089"/>
            <end position="2109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000520501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2335" mass="267758" checksum="C8E4A3635E5BCAEF" modified="2015-12-09" version="1">MRTANILMITRAISSRQRKKCIDESKSLTQIEHITDNENIASQPSITQLTMADVKKRLKKYREDFFEEQIDTISEKQKIMDDKKIFKITKKPEVSEEHILEETEKVTNIYDEKQEETFEPVIKKEKIFEEKLPKHEEVEYEYEAARELARSPEVSEESIPEKIKEVAVALEEKPEEIIEPLVSKEKLFEEEIEKIPRKEEVEFKYEYEVEYEYAARELARSPEKIPGKEEVEYAVDVYAKAVRPEVSEEFIPAEEEFEPVITKEKIFEEELMKIPGKEEIEYEYEAARELARSPEVSEESIPEKIKEVAVALEEKPEEIFEPLVSKEKVFEEEIGKIPGKEEVEYAVDVYAEAVRPEVSEEFIPAEEEFEPVITKEKIFEEELMKIPGKDEYEYEYAARELARSPEVSEESIPEKIKEVAVALEEKPEEIFEPLVSKEKLFEEEIEKIPGKEEVEYAVDVYAKAVRPEVSEEFIPAEEEFEPVITKEKIFEEELMKIPGKEEVEYEYEAARELARSPEVSEESIPEKIKEVAVALEEKPEEIFEPLVSKEKVFEEEIGKIPGKEEVEYAVDVYAEAVRPEVSEEFIPAEEEFEPVITKEKIFEEELMKIPGKEEIERDVVGIAELTSAVISEESSLVVFKHAADDFGKRVEEISASLVGAVLEGKLELSSGREDAEIVFCDFDRSREFSDDSIPDESSDIIVHERFASTIDFDEQTAEQNARGLTTEPTIRESDGNEEDNGEPLAYSEDNTGTRETREEDMTEREKLLLIRNAKSNEESISFGEKLKSFGKRTGIVIGGVVAAPIALAALSTKLAYDYATKESEEEKLVPEREYEKQIFPERIKETGISEEPSPDKTRLVTTFDRKPKEETMVPRTEKQISDEELDLRGTKDVEESEYETPVFEEELIRRTEISEEPSPDETRLVTTFDRKPEEEAMVPKPEKQISEEELDLRSTKGEEESEYETPVFEEELIRRTEISEEPSPDETRLVTTFDRKPEEEAMVPKPEKQIYEISDEELDLTGRKDLEESEYETPVFEEELTRRIEISEEPSPDETRLVTTFDRKPEEETMVSKSEKPISDEEIDLEGQRDIEASITNVFHESIRTTEISRKPSPKIIMENAEFIPGEAEEKDEFAVILPGFSYERMKDRSSYDKDFPLDFHEQEQSTSGLEYGNEMDKIHDYASMEPSYSGEGFQRDDELDVKEQEHLPSSFGEKLKDFAKTAGMMAGSVIAAPVALTAVGASKVYDYAKKARHSEPLLEADMEGREEILERDVDVAKGIAAISADFTESEDTEKYRTSEPEEEMEEGTWPSTATLPISISLDRYEEDESKIAVKPSEFDKVRLPHFVNDQKIQKYESEIPQEEIYFPEIPGKESEQQKCKQFEKFYEDEYDTTKMIFTDKVINEKEERTDTEEDTERMSPFEIIDKTDIPISDEQLFEERKILETDDFYDETFEKIEKDEIQDEKKDESQYLTEIQFTDIIDKAIDKDFDEKSDNESEISSIILNRVINLCAKQLIDEVLKEISELFFENDENEFYAITTKSCSSKIIEHEDDYQTDLQEKLDLLAMESQKIHFNSFDKNFNESIRSEIEKEKVDEIYSSEISEMINDIIQKAEENLSNSDSATFKTAISTNYETCVTSQDDTFETALGSQESDYTTAPSGDSDISDTRYGSVTPIAMVSPVQSDRNFIALQDIEDFIPTNSKSSTPDAHEIVLMTTDDYEEDDDEKIHSAVSGSLIAPRMDPGRPISPIPPPALIEEEENDIDIVETMKIAYHFQKPQVAEDATIEKYPSQEESFISKDIPIVTSMSTTEKSQIIKRIPSDDMIHEKAMDLEKDLIRRYSDISSSSRADTVICKDSVEPQSTSNIDQITSTAITDMPCDSLDSLDKISIKSSSSSGKRYSTSRRSSNGSRKSPFEEPQTFIERLTPELKIIFTENDQESSKSPPISCLSPEQEFDNYSSKDLSVHTSEIQLETVDEEPEEIDSLNGRSGSSSNGQTIDSIIMAKYKHISSDNVSETSLQEFERIERDVMNKGESSLSGSEMELYIASKLKTTTNGSTSSLAEFERLEREVSEISPQEEIMILSDIREESEIESEMSTQDDDDDESDSIPEVKSIPVRDDTLVITPIASPTDSIEKDFVNVIPELLETSTDSLELCSSSMISHFIPIDKHLSTDYEIIDKTRENLHDSLENIMQDKDSVLEGASSQEMASQDTQLVLSGDTYQEYQDEDKDSLVGDMDTMLGEYPTTLTTYETVQLKEDGSVEKIYRQVLTRVRDPIISHVQFTGTENEQRLRELVREEEYETMDSEGNVTRTILHRTSIPKKEDEAKKWYANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDF2</accession>
    <name>A0A0N4UDF2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl-coenzyme A reductase</fullName>
            <ecNumber evidence="3">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9159</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDF2"/>
    <dbReference type="STRING" id="318479.A0A0N4UDF2"/>
    <dbReference type="WBParaSite" id="DME_0000536001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000536001-mRNA-1"/>
        <property type="gene ID" value="DME_0000536001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000536001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="41994" checksum="429F59E488B78B7F" modified="2015-12-09" version="1">MVKILKKKIEIVPFDHSVQGACCENVIGYMPVPTGFAGPILVNGRNYCIPLATTEGALVASVSRGCRAVSRVYADGMTRAPVVQFGSFLRALYVSRSLQYLIYLFEKFVFFSFAKLIHLQVLPNDRELYLRFVASTGDAMGMNMVSKGVNAVIPFLKKNFPDMEVLSLSGNYCVDKKASAINWIEGRGKSVISEAIISASVVQSILKTDVDSLVNLSITKLQKGSSMSCTIGGWNAQAANIVAAMFIATGQDVAQVVSSSMCFTTMEKNSSGDLRISCSMRCLEVGTVGGGTFLPAQKACLQLLDCAGGNKISPGANSKLLAEIICSTVMAGELSLMAAQCTNDLVKSHLRLNRSGILMHLRQFKSKGHIDSKKTMNKTFERQEIISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDR6</accession>
    <name>A0A0N4UDR6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS593</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDR6"/>
    <dbReference type="STRING" id="318479.A0A0N4UDR6"/>
    <dbReference type="WBParaSite" id="DME_0000548701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000548701-mRNA-1"/>
        <property type="gene ID" value="DME_0000548701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000548701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30246" checksum="761A462982457419" modified="2015-12-09" version="1">MLVLYELGKGGCGIVYKVEGTRGKNKGLYAAMKAEFADGKCHKLPKTLAAEAFVLRRMQWSKHFCRLHLAGRRSPNCNIVIMSLVGRSLSWLRRQNPGQRFTLSTAIRVGLQCLQAVEDLHSTGFLHRDIKASNFAIGHNRCRTIYLIDFGFARSYLEKINGELKHRPPRLVAPYLGTRRYCSINAHKRIDQGAHQQFGEEYLLRNCPYEFYKIYDHTNALNLTERPDYDMIKNKFYEIIERKKYLLDDPYDWEEGGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDR8</accession>
    <name>A0A0N4UDR8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS596</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDR8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDR8"/>
    <dbReference type="WBParaSite" id="DME_0000549001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000549001-mRNA-1"/>
        <property type="gene ID" value="DME_0000549001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6147534at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="1">
        <location>
            <begin position="63"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000549001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18019" checksum="1CB07E20D5784505" modified="2015-12-09" version="1">MDEDELGDLTPEECQNRGICEVDPVYYSLNGNNKGDYPRNKRGKAYRLRTSGSYVFFEAHDGVMYKPGDFVFIELSQCEPYGVGLITSFKMVKRDQLSFRVQRFYRPQDVPDDSYSILIQERRDDPTLNQTVIAALEARELFSTEIQSVYSVCSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEA3</accession>
    <name>A0A0N4UEA3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANAPC4_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS742</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000007">
        <property type="protein sequence ID" value="VDN50769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEA3"/>
    <dbReference type="STRING" id="318479.A0A0N4UEA3"/>
    <dbReference type="WBParaSite" id="DME_0000569701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000569701-mRNA-1"/>
        <property type="gene ID" value="DME_0000569701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="2">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000569701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17270" checksum="C503D26212D3EE98" modified="2015-12-09" version="1">MGVLIEEKIENDVTSTHHEMLAWHPRNDWLAIVSYNAQIGGQVHFFKHQIEKVNHKPVQKANCKVTKISWHPELILLLIGWENGDVTLRYADEEKDEYSITVDNGPLNKVTCLAWNSSLENEFCIADEVLFLFLLFLLFIIISLLFKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEP0</accession>
    <name>A0A0N4UEP0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane receptor, eukaryota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9377</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEP0"/>
    <dbReference type="STRING" id="318479.A0A0N4UEP0"/>
    <dbReference type="WBParaSite" id="DME_0000585301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000585301-mRNA-1"/>
        <property type="gene ID" value="DME_0000585301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="7">
        <location>
            <begin position="325"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000585301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47646" checksum="4CA374683C6518FD" modified="2015-12-09" version="1">MERTRNERNNERSNINHSIIVIKALIKSNAQFYSHRFGLFVHYSTTDEFRKSIMQYTVCIILLFFAALSNGHFLSPAIISSDLGLKPDMIEYIAFPQSALKDTEVEIRLRCAEDVDLIFDVQFVIRSSPCDKEFFDINRLVQVKELLNFYFDHEYEIPDGYDYNEILFYKSKIQRFSCKDSHGVMLFDDQTPHVPMRVHNVVSVTPQRKIKMHADYGENLKPSDYILRSVSSIQEEEENCDFVGPRCASNKTMKKVAMSRTKREYAGVNGDSIDGGAKMSLSSWHPVQKFPVDVINFPSDRRSHNITIDVQWRGPYGYLSAIDYPLLRFYALMCIIYAILAILWLFMCLKHWKDILRIQFWIGAVIIIGMVEKTMFYSEYATMNMNGSTVDGFIEIIEIGHSIVMIVVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEU1</accession>
    <name>A0A0N4UEU1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS855</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEU1"/>
    <dbReference type="STRING" id="318479.A0A0N4UEU1"/>
    <dbReference type="WBParaSite" id="DME_0000591601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000591601-mRNA-1"/>
        <property type="gene ID" value="DME_0000591601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TIR" evidence="11">
        <location>
            <begin position="868"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000591601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1047" mass="120332" checksum="28CEFE4ACF267FDF" modified="2016-06-08" version="2">MRRRRCQCINDILEENRQIITCKWSRILPDINLFYNFPYNITKSLMIECVNDENDYHNRRIESQFNDDIFKNFYNLQNLKIKNCRVRQLTRHLFRGLNNLRSLSLYNLSLKNSSLIISDGIFDNLLKLEKLFIVNSQIQAIPSKALCRSPNLQILNISSNWLTAVNLGVNDCIRPMEQLIIIDLSLNAIKSIAANDFKSLTNIRQLILSSNNINYFHHASVNRLNIIPSTITNLINLISLNISWNKIDINTPFELHAKYIEILDLSGNYFNTIPVVIINNSINTLIHLKLTNNHIKNLNYTTLVNFSRLETVESYILSNIPRLSRMILSNNSINSIASDAFNKCPRLIEIDLSNNLISHITNDTFLNIGPKITRIILNNNLIELLQWNQLPSTLRTIELSNNLITRIDSAFKSNIKYVKLDSNRMMMLTSEQIPSTAEYLNISHNLLDNLPNATFLNKSLKILDISFNNFNRINYYSFTNNNNNNDGDTSIEIFIEGNPLICSCEMNWLISNDNNYAQVPLISSSPLLLPVTGGGNLRIKDKHLATCKHRIDKRNIPLLKVKDDDLLCNYKQICEPGCICCQYGNCDCKSKCPSGCNCYHNSNYSINIVRCLSLNNTDRSNFSPKDLPMYATNIFLENMHIPIIRSHDFLGRTRLLKLYINSSSVEEIQPLAFNTLPSLMLLDLSGNKLTTLTGDEMYRTNKVTHLFLNSNHLTSLHEKLNREMPLLQYITLHDNKFKNIPEIIDKKIDFAGLSLGQNPYRCDCDNRFRMQSWLIENIKVIADVKDIFCIENITEAFLKNDTTILSAYPPNIGHEIYAVPMLQFIENINKIKMVLKAKQERRRYKLPVKTVTTTTPITLSSSSPVPLINYDAFISYSKKDEKFINDIICRQLESEDYLLCLLHRDCPNYNTDCAIKLHSVCDELIRQIDYSQSLIIVLTKNFLENEWGTLQIKTSHCLFAKNRTKKLIALLGDGIERNELDHELGRILRKNTCIRINDPLFWNLLHSSLPLKINFYNDAGGAIPGHSNNSSQIYSDCYGNIVPSNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFF9</accession>
    <name>A0A0N4UFF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF676 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1066</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFF9"/>
    <dbReference type="WBParaSite" id="DME_0000616901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616901-mRNA-1"/>
        <property type="gene ID" value="DME_0000616901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229945" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="119"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23716" checksum="66756768FEC4EF54" modified="2015-12-09" version="1">MSYIFIHYLFLFIFEKFILGDCEDLVSYRNFLRLLLPDRNLRFLLSESNQVGAWIDLNQLADNLLNEIFIFMENCSMRPSKISLDFRFLKFFLLFILLSLRAFTIASRPHSMRVLKALFPGIAFVQWWKNSISLEQLSLRDSDSVRETFLYRLSLNNSLGLFKYVLLVGSYNDAYVPYHSALIQHCKVGFQFLNGFNEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFI9</accession>
    <name>A0A0N4UFI9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1103</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000013">
        <property type="protein sequence ID" value="VDN51130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFI9"/>
    <dbReference type="STRING" id="318479.A0A0N4UFI9"/>
    <dbReference type="WBParaSite" id="DME_0000620601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000620601-mRNA-1"/>
        <property type="gene ID" value="DME_0000620601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="328"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000620601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="514" mass="59122" checksum="050DCED2D6849647" modified="2015-12-09" version="1">MEPLVVRGDEGGAGLILCCECGLSIQPNAANMCVACIRSRIDITEDIPKQNQKFDIGSRFFCLGRLYSCRFCERYLLPPNAWIRAELESKELLSLALKKIKSTLQKVRLVDASFIWTEPHSKRIKVKLTIQKEVLTGAILQQTFVIEYVVLNQMCEDCRKVEAKDYWRACVQIRQKCDFKKTLFYLEQLLLKYGAHTNTTGIKPVSTGIDFYYAKLQDARKLVDFVVSVLPCKYQYAQELISHDTKNSTYDYKHTFCVEVVPVCKDNVICLPRKIAQSLGNMNQFVVCLRVNNVITIIDPSTLQLADINAQAYYRHPFESLCQPKQFTEFYVLDVEDVVDLQREKGHGRISSKHRLVDVWVARADQVGKTDAPIIFTRSHLGNVLKPGDTVLGFDLQNSNVNNKILDSVASDRVPDVILVRKVFDRTMRQKRRKWKLKRIVRDGNIVPDTASVENEFENFMEDLEEDEQLRKRINIYKKTDIVADDDEDYDIPFCPSVGEMLEDLDLNDVEMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFT2</accession>
    <name>A0A0N4UFT2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS1210</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFT2"/>
    <dbReference type="STRING" id="318479.A0A0N4UFT2"/>
    <dbReference type="WBParaSite" id="DME_0000631301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000631301-mRNA-1"/>
        <property type="gene ID" value="DME_0000631301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="179"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="575"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="18">
        <location>
            <begin position="759"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN51237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000631301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="937" mass="109009" checksum="1F3A4C006AF69002" modified="2015-12-09" version="1">MIYAPIVNDSFAYYRKLFEREPLMIDKLVATLEPLPLCKWLDHPDYQQMVNIIQDFMTKKCYDEASCYLLRTLPRICKKGCEPSAWYFDLLNACLHDPANRSAPEFIDPAYRIYLDTFHSQFHLARKLHEKSEVIHSELPATVDENDAIEIRAFRSQEDYKKIPHPEPIELRPYQLELTDAACKGINTIICAPTGSGKTIVTAYIISQHFRNIKAENKTARVAMVVPSVPLVEQQTTMLNRFFRRNFWLEGKSGAESIDIYGRAPYILASHICVFTPQVFINLLKSIRKDDRLYFTDFTLLIFDECHHCDGDHPYNVVLTIDFVYDVKILVLMRMLHGFDGPKPQIVGLTASLPVGSGRFNVEAAVDRMLELCANLSAHSITTVRKHFQNLQEFVIPPIDQIKSVYRPQFDPFASSIQLCMTLIERLLKPLLQEVRDKKQLELRLDEINFPSNQFSIRYESFLGHLKTRLVEMRADSSKYNLMKMLEYLMYYYRASNLSDVLPNRYAYNYLKKRIDGETDEKVYSLTPVQKHLRYLFQSKFYSHLIFFKKHVINPNTSSEFSGEDKEILQVLREILRKQLVDMPMSRIIIFVTTRLICEKLSHYLNIKGIIDQNDIAVAYVTSSNRNSTIRGQTVEEQRNILDRFNSGLLKVLVATAVAEEGLDISACNLIIKYNNTGSERSLIQRRGRARAKGSKSILLVLDGSIEEKELENIQKEELMRRCLMHIQIKSEIEMKNLVESKVKEMNLTKHLMLLQENERKKMFANKRYDLLCQMCGAFICRSTDIRVILENQYVCCDPTIWERIEMCRNFDGKSFAITTTVGRVFCKGKEKLHCNEVLGYIVNFCGAFLPAIAAKAIVMDEKDSDLVKQTKKWDTIRKEKFFIEAITEKDLKEMFISLFNFSKEKHDTFQTESYLVVRRALAEMKKERKRRIPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGH3</accession>
    <name>A0A0N4UGH3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IlGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1323</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGH3"/>
    <dbReference type="WBParaSite" id="DME_0000659401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000659401-mRNA-1"/>
        <property type="gene ID" value="DME_0000659401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5784897at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000659401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9480" checksum="88FEBAD83533D787" modified="2015-12-09" version="1">MLISAYTFSSLQAHTIIAGLADLIEAGGLSFFEAYQMACPMRRKRTTTNLGETKYRKATLKELMEICCIRGCDIADLSGYCGPFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGS3</accession>
    <name>A0A0N4UGS3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9734</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001189">
        <property type="protein sequence ID" value="VDN59761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGS3"/>
    <dbReference type="STRING" id="318479.A0A0N4UGS3"/>
    <dbReference type="WBParaSite" id="DME_0000670801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000670801-mRNA-1"/>
        <property type="gene ID" value="DME_0000670801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866690at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="55"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000670801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29291" checksum="EE57A39F486B19B9" modified="2015-12-09" version="1">MCLISAASYADHPQSCLSQAVGDSQVVKQYAVKCNHSNRSICAGFIAISKKAIILAFRGSTSVLQVVEEINEVAFSATVPFIGGGNVGRYFNDAFMDIWNDSMKDDFINLTMEYPNHFIWVTGHSLGGAIASLTAGAIVAEKLCDANRIRMVTFGQPRTGDYNFASRQDQNIPYSFRVTHAADIVPHIPPQNFHGFNHHGVEVWYNNEMSVKDSYLICIGSDPLNCSNSIPAISIEDHRRYYGILMSLYWMQNCTNINYNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH06</accession>
    <name>A0A0N4UH06_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS1412</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="14"/>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH06"/>
    <dbReference type="STRING" id="318479.A0A0N4UH06"/>
    <dbReference type="WBParaSite" id="DME_0000679801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000679801-mRNA-1"/>
        <property type="gene ID" value="DME_0000679801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000679801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="712" mass="81116" checksum="9A039500E28B2AD9" modified="2015-12-09" version="1">MNQIGFGAAVPPDKNYAQLVDGDDVIHIFGYRTSASKTVLTWILTILTFGLFRLLLHWCPNLLMWCTSSSCSLHVADYVFVRDSHMNVTSRPIHVLRSGDGDYIAVPIGGFRITNVHMLRYFTYKKLKYIWYAEEMRFIEISSFDDEVDFTFFHSLVECGFSSTDVLKRRKIYGKNFIQIKPKPLFLLLFREVLTPFYLFQIFSVTVWFMDDYEIYASVIVIMSMVSIALDMYQTRKQEKGLMNMVHTSGIVEVVRNGGRMEQVGSDELVPGDVILIPSHGCKMHCDAVLMNGTAIVNESMLTGESVPVTKVALPEVDDECINLFTIKEHSRHTLFCGTQVLQTRYYSGKRVKAIVLRTAYSTLKGQLVRSIMYPKPVDFRFTKDLFKFVGFLACIATIGSIYTLVVMIYRGSYLRPIIIRSLDIVTIVIPPALPAAMSIGILAAQIRLRKKQIFCISPSTINTCGAINTVCFDKTGTLTEDGLDFHCLRPVNRFGIKPYFEGEIDTFNSIKLIQYGELIKAISCCHSLTRIHDKLCGDPLDIILFKNTGWYLDENICSKIDETDRFDLLQPTVIRSSSDHTSFFGEIELSIIRQFTFSSSLQRMSVIVHNPKEESRSMSIYCKGSPEIIASLCRRNTIPENYTNVINEYAQHGYRLIAIAYKELCISFAKSQRVKRESVECDLELLGIIIMENRLKPQTIGVINQLNKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH56</accession>
    <name>A0A0N4UH56_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1473</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH56"/>
    <dbReference type="STRING" id="318479.A0A0N4UH56"/>
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        <property type="gene ID" value="DME_0000685901"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000685901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14868" checksum="82FDA545BA88F336" modified="2015-12-09" version="1">MFSPEGNMKSGWKSYARSKLALSILAHHLNGKDGIHAISVHPGIVQTSLSKPISSKTKNLLHMIRFNRFTDTLEEAANNVVEAIETQHFTGTYRNGKYFSRECRIVRCAKNGSELENLSSKMIQFILNDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHD8</accession>
    <name>A0A0N4UHD8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1542</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000024">
        <property type="protein sequence ID" value="VDN51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHD8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHD8"/>
    <dbReference type="WBParaSite" id="DME_0000696301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000696301-mRNA-1"/>
        <property type="gene ID" value="DME_0000696301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5791600at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="251"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000696301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="675" mass="77490" checksum="AA2E0AFC406CC6D7" modified="2016-06-08" version="2">MQFEEIYDKILQTLGSFAYETWLDKIHCESNITDNLQESIVEFHNEMRSDLARGDFDGYESGTNIYTMRWNCNLAKLAQERANSCGRTKELDYFSGKIGEVTYQQLANESKNNDDYFNEAMDYWSNATEPLNQSELYKVGPACETWKDCSTYKESVCYFDSKLCDFHSGKEIHDSFDTFLASNGTIDIPNLEEHTTTFSINSSHGNINDSENDNVKYNGDRVAQWVVAQLGAPMLRFVAAQSCNKKSISDDLRADILFIHNVIRSQLAYGDFKSLPSGSNIYSLKWSCELERLAQQNADFSIETCKMSRKQDAHIPFETGQNIFKIKTNESFNTDHWFDKALDFWTNETRESHEVAQILYGKTLLIGCGIRKCRESEVVIVCQYWPKATPGPLYRQGSSCETGNYCDAYNQSSCDSEMSLCQVASDFTFPDPLHALPLQTTPITEVPNIENVTYTPTTEMSISSETLEKIVLKQYNCHDTKLLTSYRSLLKMKHEEYRKKAAKGIITLHNFENIEEDFFFKLDWNCELEKEAQKEAERCALPPHDAKHKYYRTIIHNFEFGNLADFLDQKIDYAISNWWGNITDYDNINIAQFEATEIGCGIASCIDENLQMVIDIVCRYWPTTNPNELYNYAISCERNEHCDLLPNSFCDTNLGICVEGEARKKSSVKKSLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHY8</accession>
    <name>A0A0N4UHY8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS1665</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHY8"/>
    <dbReference type="STRING" id="318479.A0A0N4UHY8"/>
    <dbReference type="WBParaSite" id="DME_0000719401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000719401-mRNA-1"/>
        <property type="gene ID" value="DME_0000719401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN51692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000719401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39794" checksum="DBC5E4148D1C443A" modified="2015-12-09" version="1">MPRIEYELKLDFKDVLLRPKRSTLKSRADVDLTREFVFRNSKKKYEGIPVVASNMDTVGTFEMAEELSKHLLFTTIHKHYTVEQWLDFTRRNSNNLKVFSQIAVSTGIADNDWTKLNAICNEISALEYICIDVANGYSESFVDFIRKVRETFPNQTILAGNVVTGEMVEELILTGADIVKVGIGPGSVCTTRRKAGVGYPQLSAVLECADASHGLNGHVMSDGGCTNSGDVAKAFGAGADFVMIGGLFAGHAQCGGKIFEKDGKKYKLFYGMSSDTAMRKYHGGVAEYRASEGKTVTIPYRGDVSKTIQDILGGLRSACTYTGSIKLKELSKRATFIRVNQQLNDQYTGLEIPIQSPYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI03</accession>
    <name>A0A0N4UI03_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1684</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI03"/>
    <dbReference type="WBParaSite" id="DME_0000721301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000721301-mRNA-1"/>
        <property type="gene ID" value="DME_0000721301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864341at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041079480" evidence="1">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000721301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34372" checksum="32560EA606937E0A" modified="2015-12-09" version="1">MPMTVVSLLEIFTLVISYKVKNNQDCSQPSAIELINGPIHWAVIEFVDQISGHFNITAFQIKFARWINEECGAVIDCQLSRPLTSNNIVVNFRQNATNANTVVLLVFKDHCLPIDSKNMMPIDIIIAVIRSREHLLSSLAHSDLKSVYSNCTENAWPAQDNSIEMQTSRPESVNVSRTIGISRSKLAIMSKIRLAAEDPLVTLSSSDSMVKGSDTFDTASAVSSAISRSSVSMLQLCRQMIEIKISSMRNFNCIKSLPKPDMIIIVGHWNARVGRVRCRCDDLNNWQIWHRRPMCQWGMSSLCRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIA2</accession>
    <name>A0A0N4UIA2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS9962</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001197">
        <property type="protein sequence ID" value="VDN59989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIA2"/>
    <dbReference type="WBParaSite" id="DME_0000732601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000732601-mRNA-1"/>
        <property type="gene ID" value="DME_0000732601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF192">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="272"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN59989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000732601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="572" mass="64671" checksum="528E130F096CE367" modified="2015-12-09" version="1">MRKFDCIERPLSRLFYRYGRFVALHPLPFIVIPLLTTAACAIGFLHLHPITDAVYLFTPTNAPSKRERLIVHNLWPLHDHNYIAGRTVTQSREIQVIALARDGGNILVPPYSEATHRLDLFIQNRVKIRYKHHVYGYSDLCLMWKTSGCPGNKHIHIVSDLFNHGINITYPMVRFGTTSGYIGGALGGVSLSLGPSNSSIIAGARAWFMVYHLKFYPHNISYISGLWEKELQRRLESYPVDPYITFTFLHSQTLPEELRRNADSLIPRFVIAFSILVVFSIICSVVFISGTLYVDWVLSKPILSLLGVINAGMGIITGIGITNFVGVPSSDIIGVMPFLLVAVGTDNMFLMVAAVRHTNRAYPVSRRIGECMSDAAISIMITSLTDAFSFGVGALTTIPAVQIFCIYTCVSISITFFYQITFFCALLSLATEWEKDHLHCLFLRPTIPDCDIKNVSLCTRLFWLGSRSDPDPKNVAKNLKETGAMLFFQEWFAPVLMQPIIRVLVGIWFVIYIAISIYGCIHLREGLEPVNLLVEDSYAIPHYRILEKYFWHYGAPLQVLFCYFLISLNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJB7</accession>
    <name>A0A0N4UJB7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS10154</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001204">
        <property type="protein sequence ID" value="VDN60181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJB7"/>
    <dbReference type="STRING" id="318479.A0A0N4UJB7"/>
    <dbReference type="WBParaSite" id="DME_0000774401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000774401-mRNA-1"/>
        <property type="gene ID" value="DME_0000774401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF62">
        <property type="entry name" value="DNA TOPOISOMERASE 2 TOP-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="6">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN60181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000774401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35991" checksum="95D7D1E906A2BD9A" modified="2015-12-09" version="1">MSSDSDISFVDEPPVKIAPKKMKKTANKVGGESILNGDNDNSNKINKEDPMKVFTNIDKSTKRLSIEEIYQKKSQLEHILLRPDTYIGSIEFTDKSLMWAYDEEEERIVQRELSYVPGLYKIFDEILVNAADNKQRDPKMNLIKIAINKEKNEITIFNNGKGIPVVLHKVEQMYVPELIFGTLLTSSNYNDSDRKVTGGRNGYGAKLCNIFSKRFTVETSSKEYGKTFKQTWINNMTKDKDAAISKATTEDFTRVIFSPDLEKFKMSVLDDDIIALMSRRAYDIAGSTRGVKVYLNNKLLPVSDIHHHFIFYGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF0</accession>
    <name>A0A0N4UJF0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1982</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF0"/>
    <dbReference type="STRING" id="318479.A0A0N4UJF0"/>
    <dbReference type="WBParaSite" id="DME_0000778501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000778501-mRNA-1"/>
        <property type="gene ID" value="DME_0000778501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF331">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000778501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="56337" checksum="1D6837CDC89D15BC" modified="2015-12-09" version="1">MTSTDSDIRSSPEILYRWFPSSRFLTASLLCICYASIHMMNSNMGMAIICMVNSTEYDDNSENILANMPMPIILLSNNSIFDGNNTKVYTIPNLIGAPKVNWSSEEQGYVFGAFNIGLLSMLIIGLIADKINAKYMIIAAMLIASVANFLIGFASSLSVNIAIGGRLLVGVSDALLQPAANSLLTRWFPPSERSYALGLATGGRQIGSLVIMPVAGTLCNQNAFFGGWPSIFYLSASVGLFFIIVFLCIGADKPSKQFLITDSELHFIMKSIACEDAGKKRIERKIKWRPIITSAPVWAGIISVVCHEYPLMTMIMFLPSYLHDVYHYKATENGFLSALPTAALWISKIVSSYLNTLLLQRTNFRRTTISKMLNTVGSAGLSVFLYSVTLLDSKNASLAVVFLCISMAFTGLHTPGCQASLVSIAPAYSGAITGLAFFFVAIAGIVNPIITKWIVQDGSPLQWNLIFYISTIIAFIPVIVFNIWGSADVQRWAIMDERKTKSSSQAAKNAVIPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJF5</accession>
    <name>A0A0N4UJF5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1987</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01000040">
        <property type="protein sequence ID" value="VDN52014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJF5"/>
    <dbReference type="STRING" id="318479.A0A0N4UJF5"/>
    <dbReference type="WBParaSite" id="DME_0000779001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000779001-mRNA-1"/>
        <property type="gene ID" value="DME_0000779001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="103"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000779001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33494" checksum="1D76F29157F79033" modified="2015-12-09" version="1">MEKTHGESDFPCLKCRLLIFACLCTIIIFFLTKIPICRYFIKMIAYYLTVLTTTILCCTISTAIYFFGDVPKFIFGAFRILASWTNIKYEVRGSQNFDGIGPFVVVSNHQSSLDILSLAHVWPERCTVMMKQSLRWVPFLNYVAFLSRAIYVDRFCHTKAVHAIKTSADTIIAKNTSVWVFPEGTRNHEGGMLAFKKGAFNIAVQVQIPIVPVVISSYRPFYDKNLRIFNEYGYVIIEVMEPVLTKNMSLDDVPLLTDRVREQMMEVYERISGEAAEKCKLKTSFMLRCISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJH6</accession>
    <name>A0A0N4UJH6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS10184</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001205">
        <property type="protein sequence ID" value="VDN60211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJH6"/>
    <dbReference type="STRING" id="318479.A0A0N4UJH6"/>
    <dbReference type="WBParaSite" id="DME_0000781401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000781401-mRNA-1"/>
        <property type="gene ID" value="DME_0000781401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF89">
        <property type="entry name" value="FI03229P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="126"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN60211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000781401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="663" mass="76281" checksum="A2FE0FE20028717C" modified="2015-12-09" version="1">MAEAGLHSYSQMTQNIRICHGSNIEHDEERITLPDANESVFSSPIHCVAPSDIMLSTTNGDQHSRLGLRQFDRKQIQYFSNIDLFQQPSGFNYLRYARADELRHEENTNPHFYISNLTFIYDFRTITDRIILRPPQNLAILNDVSFELSGGETLAILYTSEFEIRTLLCILAGRMTHGVSIKGTFQINGHNLEIQQLAKMIAYVSFEELYPWLTVKQTLFFMSAFKKSATGTFKIENMIDQLIQTLALSPYRNTLCSEIGKTERQRLKIAIQILKDTDIILCENITKDMDLYDSSFVIDYLRDFANKLNRIIIMAITPPTIEILTMFHKTLLLASGQVIYFGRSSEMVHYFESTGFPCPLLKNPCDYYVDLVTHDNLTPEASSESIERIRRLSELWKQNYTLRHPKVTAPLSSKIAQANSFEAMVIIYRRFFAIYKNRPWSIMKEPFYALLTSLSLGAIFFDIPADRRAGIDDRFVSDERLFLYQDLCNQFYGSIGYLFTKIIFDFPFSLFTYILYALPAYIMSGLPPKNELYWPFIISFATIVILNSLLWRYASWMFAYAFGSRTTAAFASAALMGLSALASGLLVHPYDLLQFAKWTHFISPIKYAGEILAENEFKGTSPLLEKVIAMITNKHKSWNRTELMIGCERKRVLAAKIREIDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJI3</accession>
    <name>A0A0N4UJI3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Organic solute transporter alpha-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10192</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001206">
        <property type="protein sequence ID" value="VDN60219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJI3"/>
    <dbReference type="STRING" id="318479.A0A0N4UJI3"/>
    <dbReference type="WBParaSite" id="DME_0000782201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000782201-mRNA-1"/>
        <property type="gene ID" value="DME_0000782201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000782201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39281" checksum="A1A7F48662A451C9" modified="2015-12-09" version="1">MMVIDTIFKLITDSLLNCTDHADASNIHEVPSAYVYLSIWQISEIDLTFMSTLILATLISITTVLLSVIHIIYILFYVTERYRRAFILYLAGTSPFVSIFAIISMYMPRIWFLAHLLGFLYFSIALWIIIRLLTNIFEGRQKMIKKMKIECSKITVQTPPFCCVFPCLPKLELETGRIRFCELMVFQAPCIRLICTIFSLILFFEYHNGAIVALKVLDFISLPSLLIGIYGTHILATAVSKMDELMPYRYIVVFRLLDFYFMFFGIQQPIFDFLARAGIFGCGTVLPPLETAFFWKNFLIVFESFFVSLISTMLLKPSRSALFDKYPSCRSSSSLATKESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKI0</accession>
    <name>A0A0N4UKI0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2298</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKI0"/>
    <dbReference type="STRING" id="318479.A0A0N4UKI0"/>
    <dbReference type="WBParaSite" id="DME_0000822201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000822201-mRNA-1"/>
        <property type="gene ID" value="DME_0000822201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865602at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF165">
        <property type="entry name" value="BTB AND MATH DOMAIN CONTAINING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000822201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14957" checksum="C48540D1211F1AFB" modified="2015-12-09" version="1">MVKVYFSNTTEVPLEANVDPLMFHETMEVFRGRLSLDEKNIDNVIYIADKFKIKPLFSHCQSFITDKLSSSSVMHAIRLAEQYRMAEIKQALFDTISIDVFRSLAADQDYRQMGPELKAELLEKWGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKM8</accession>
    <name>A0A0N4UKM8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2332</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">High molecular weight complex that consist of phb-1 and phb-2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000055">
        <property type="protein sequence ID" value="VDN52359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKM8"/>
    <dbReference type="STRING" id="318479.A0A0N4UKM8"/>
    <dbReference type="WBParaSite" id="DME_0000830201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000830201-mRNA-1"/>
        <property type="gene ID" value="DME_0000830201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030421">
        <property type="term" value="P:defecation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000830201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34048" checksum="F71CF5C335B59DEE" modified="2015-12-09" version="1">MFRKAMGNAKGSAFGLGLVAAAGAAAYGIMQSIFTVDAGHRAIMFNRIGGVGADIYKEGLHFRVPWFQYPIVYDIRARPNQIRTPTGSKDLQTVHIALRVLSRPDPNSLQKIYRMLGQNWEERILPSICNEVLKSVVAKFNASQLITQRQQVSLLVRKGLYERALDFNIILDDVAITELAFSSQYSAAVEAKQVAAQEAQRASFLVEKAKQQRQEKIVQAEGEAKSAKLLGEAMKQDPGFLKLRKIRAAQKIAKIISEAPNNRVIIHSVLHFIDKNFLVYLPSGGLMLNIADSDYLNFDKQGPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULE9</accession>
    <name>A0A0N4ULE9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2537</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULE9"/>
    <dbReference type="WBParaSite" id="DME_0000862201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000862201-mRNA-1"/>
        <property type="gene ID" value="DME_0000862201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000862201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11328" checksum="2627E968781B276D" modified="2015-12-09" version="1">MAMDVIKQRARLVKKLISDIMYVPAEDLEKKSDIVEEMIESKKINGTNENNETSPVEDIHSITVGNVKQVASKRSFDWMTIFVELVAKKVHSFLCSNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULF1</accession>
    <name>A0A0N4ULF1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULF1"/>
    <dbReference type="WBParaSite" id="DME_0000862501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000862501-mRNA-1"/>
        <property type="gene ID" value="DME_0000862501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000862501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="744" mass="86153" checksum="FAC371975AB74BC2" modified="2015-12-09" version="1">MAQYREEQQQHHVTRNFYHQQRLRTATATMNGNYSALFFKSKSNQHTLNYINLNYWRQYCNYLPLIFRELLFNNYLLSRNNQRATTITTTVGEFSSSEQPWINFNFFLSPVATMQARQHRRNGLEILPLLDIYGTKPQQQHDLSPSTLSTSSSGVLSVDDHNNKSSTNKVPLSSFAIKHGNSGNNLDNIKNDGNNDKNNDNNSNSRSEFERRLSTTALTKAYFNTNLKRQKLEQKENIEKLVAEKLLVKDSAEQHQYFILNNKFSWIVKNHRKSFELPNKVCIKFLVFVSQPDGILLRAFQPSAYDSAYTACLIGPHFSVPKLIDNECLSEVCLLPNDGKTAQQHYDLNANPLSRTDNKLSEKPFFSGTSCEVPHATKVSDQREFLSENYNAQNFPKLPRHLLTDYYRRDNQRKISSNENLKKDYISGSNYYNNTQQQRSSRKPLSSRQTQRDVYIPQYINDRQQSYSRSASQSVTVDFERGFSLKSSGNRYQRNHPARFLGIRSGSYRNYRDRNAYYGRRSSSSISQNEQEDHGRTQKNSGSRNQDVLSKYPMKPFCNGANLYPPTVMHVTSSTSRIQNQTQIDKDSEENIFDEVMSNLANEIQHTLSSEHRPNLRDELSNCSLEINKGTDNRLLFCNVLLDSQKENLRSFDGVHLLPSEISMISRENYIRRCEKLNDYQIQRLMTIANVSCSDRSNQLFAEILFCSSPYKHSLFLAWLAELIARELFEDSEKEEHLGSDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULF4</accession>
    <name>A0A0N4ULF4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LLGL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2543</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000066">
        <property type="protein sequence ID" value="VDN52570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULF4"/>
    <dbReference type="STRING" id="318479.A0A0N4ULF4"/>
    <dbReference type="WBParaSite" id="DME_0000862801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000862801-mRNA-1"/>
        <property type="gene ID" value="DME_0000862801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="7">
        <location>
            <begin position="226"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000862801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="610" mass="68372" checksum="12CD03CF0BE8B4C5" modified="2015-12-09" version="1">VARHGFPDDPRCIAYDPIQRLLGIGSGHGSVRVLGNIGVDYFLKHEFDAPVTHLQFLINEGALVTVCRDDMVHLWNFRQKVPEIVHSVQMNKERITSINVPFQSKWLHIGTERGNVYFVCVATFALSTYVINWNKAIDLACRTHPGGVQSISTCPADSTKILILYEKGVVVLWNLVTKEAERFQCERVIRSLSWHYDGRQFLCGCADGSLVIWNTKKPSEFQQKLTPHGQRCRSVIQVDWMHFSDDEHLMIFSGGIPQDEGAMPSLTILRSSASASVLEMDYPLIQFVPLVMTPFTNAPQQPFGIAALLKNDLLVIDLCSPGYPCFENINPMDLHESPVTFLRYYSDCPLDVIGALTLVGCKQRRQGYSEKPWPISGGTSRECASSHQELLLTGHEDGSVKFWQTTGENLQVLYKLKSGRHFERSGAGNHEFSNAVVNIELCLESRLLLIGGQSGQVTLFHFVKTESAHEIAVRNLKDLKDLTDPFVIHIPSSNVSLYDEEPHCFSNSVKELRRQGKAISQESSYSTDTSEGSNYSDYFPLKVRGGALRRPAGYQPELVCLIPWRNSAQSEVITSLALNSVYGIIAIGIFLNFNISFISFHFIFIHCSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULH9</accession>
    <name>A0A0N4ULH9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fission factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2569</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Tango11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000067">
        <property type="protein sequence ID" value="VDN52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULH9"/>
    <dbReference type="STRING" id="318479.A0A0N4ULH9"/>
    <dbReference type="WBParaSite" id="DME_0000865401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000865401-mRNA-1"/>
        <property type="gene ID" value="DME_0000865401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5986838at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039433">
        <property type="entry name" value="Mff-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008518">
        <property type="entry name" value="Mff/Tango-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501:SF6">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05644">
        <property type="entry name" value="Miff"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Mff-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000865401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19620" checksum="92BDEE8746B73C91" modified="2015-12-09" version="1">MNVPQHISVDGDETIHRQRPRSITDGSDLAYQMNVPERILVAGGDKIVSERAPPPELIADRLLSIYPTEELSTPPKKLTLDIATYPDIEEDSHLHSVNSGNIQEQSMSAESIAVDENPLRELKKMSKQLIRLSNRLYQLQDEQERRKTRESIALIQLFFLTGAVIYLFLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT5</accession>
    <name>A0A0N4ULT5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2667</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULT5"/>
    <dbReference type="STRING" id="318479.A0A0N4ULT5"/>
    <dbReference type="WBParaSite" id="DME_0000877601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000877601-mRNA-1"/>
        <property type="gene ID" value="DME_0000877601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000877601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="751" mass="86226" checksum="0C6A54D638D51912" modified="2015-12-09" version="1">MRCVVVEGVAVPAAIASLFSDPTKRPFSYTQPLPSPVDDHQSHNKSHLVVPSVLPSLPLQSSKTMPFNNIQYNSPMPIYSREAAEEQYKQQIGTGPAIPLSAPDKHFDPEKSETLKAIHQGEDNTFGEHFFEKIAAAEAPHVPVTNEPSWTLDAKRRSERARSVTPNATFTSPTSMYHGPSYTTLQRVKTRTHDSGKEMAPKRGYEFGGLDFVDKSRIPRDSSYYYEPPHTIKHEEKRLNRGYEMGGTDFTRSGMVAPYGPYHGHGPERPKLHSKYVDTPLKQNELNIETAPNVEKVSPDILVGDTLSNQHISKNEHSREMDTFGTYFGPTPGFKRDHRTVERNIEPPHPPVFSLSAKKHTNGQYGSIDRQRHRYDHFSRKETTTAPSNFFEHTSQTYARKPRSHSEAPLDRYEWNEANNKEVTIETLLNDKALIARKREYTPDWQSRSLEKQNRWKERSDPRLFRPQMYANEPTWSETVRQRRDAWESKARITDERVQLPPSYKVPPQQPPYWYNKASKTHNIWQQEADRQIYAEDGQTTGNYGKDMISNSHQDYNSFTSRTQYVHREKQDGPHYNQFSEHEVPITQTTHRTYSAIPYQRNSYETSSQRDLNQQPAASHSYDIQRTSNYYRQNQQAFPTKSTSATVISQGAGTHIDRRAEMAEALPRGTIANTEATAEGNYLDADGKHVNYKRELTTSVDPHIERTLLKEEESRIIETPLEPGIISRHITTKYYKKKTVTDTTTTTTNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMC6</accession>
    <name>A0A0N4UMC6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2796</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMC6"/>
    <dbReference type="STRING" id="318479.A0A0N4UMC6"/>
    <dbReference type="WBParaSite" id="DME_0000899301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000899301-mRNA-1"/>
        <property type="gene ID" value="DME_0000899301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF137">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039989" evidence="3">
        <location>
            <begin position="23"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="328"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000899301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64056" checksum="FFE640D3BA5E1758" modified="2015-12-09" version="1">MKIRLDCLIFAFLTFICCRLSSDDLISPLLQVNTNSKNAGIFMRFMPTGIAYLREIGMKTVNNEILRIKLPLVTERVDAGQVTIYNAYVSKYWSPPEYNLELAPPDMFTWSMSKMHIRAAGDFEVSAHNPLLLPTVPIRGQFETLFGHISLAIAIRLGRSEDGAPRVRSTYCQADVGYVDLNVTNTGVITDFFINSFKAFIIANFKPVVQERICKMIKSVVNNNMNQILSTMPLQVHLHENTIDIIGETFGLSEKKPLSRYGDLGARNITLTNIIHNLRKQNLILDYRLIKDPLIAYGSIGMYIKGEISWNGYGGTPFDPPNVEIPPPHGIHMVEFFGTDYLANSMLYHAFRQKYMDLKIGPESSNRLENLLFTSCKVGFCVGEQLGLLSEQFPDREIEIHFFARKSPILVFVEKRARFRLYGGMDMYVRPANSSQVKIKILKCDATLTSTMYLQIDEFRVTGNASVETLDFKLRETIIKDVTQETLNDLSLFAAEFLQNILTEILKIGIMMPKMKGVMLKNPKLSLHERYLKVQTLFKLDERFTGRILEGAVQESLKNFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMD5</accession>
    <name>A0A0N4UMD5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase_M24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2808</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000081">
        <property type="protein sequence ID" value="VDN52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMD5"/>
    <dbReference type="STRING" id="318479.A0A0N4UMD5"/>
    <dbReference type="WBParaSite" id="DME_0000900501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000900501-mRNA-1"/>
        <property type="gene ID" value="DME_0000900501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000900501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50753" checksum="9D3F25B90B189176" modified="2015-12-09" version="1">MTSKPKQVSESTEHSDDEQQSDSLSNDLVVTKYATAADIVNFALKEIIKEVKSGVEVGFLCDLGNKIIEDRVSKIFKKEKELQKGIAMPTCISVDNCICHYSPLRSDPPVCLKDGQMVKIDLGAHVDGFVANVAHTVVVGATHDNKVVGNKANVMLASYHAMEVVLRMLRPGLYKNFQITDMIDRIAAVYSVKPIENVLSHQLEKNKIDGGKEIIQNPGEKQKELPKCTFEKHEAYAIDIMMSTGDGRARPQDARTTVYKKAEDIYSLKMKTARIFYSQATNKYGSMPFTLRSFEDEKQAKLGVVECERHGLLRPYQVLYERDGEYVAQFKCTALIMPNGILKITGLPLDMDLIESDVKIIDPEINALLTASLKPKKKKNGGEKKADDKSAISNEENETKINTNKQLNTPNAGKDKGEKSSIADHANNKTAKKKNENEKKEDMKEVVRREERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMK2</accession>
    <name>A0A0N4UMK2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS10587</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001227">
        <property type="protein sequence ID" value="VDN60614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMK2"/>
    <dbReference type="STRING" id="318479.A0A0N4UMK2"/>
    <dbReference type="WBParaSite" id="DME_0000908301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000908301-mRNA-1"/>
        <property type="gene ID" value="DME_0000908301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF95">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR C06G4.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN60614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000908301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41217" checksum="2B3A8F12F0E48B77" modified="2015-12-09" version="1">MNYDSLEITYVLPPPNHQDPQVLIMASAYMLLFLLGTCGNVTVLTTIYHVSRLHRARLDNTLLYVIVLSCVDFGVCISLPFTVLDQILGFWMFGSVICKLQALLENFGKILSSLIITAMSFDRYAGVCQAQNKCLRSKKMTASILLGLAAYALITLGPLLWSFNTKEIILFEKKTAPHKLTRMQIEKCTMVNVSSSVFTMFTVYQFILCYCLPLSLVAFFYIKLLHCLREHKRQFKSSHIPLLRISLYTFALACFYFICWTPFWISTLYAIYLEYADENGKTVSPAFVYSMYFIHALPFTNSAINWILYGLFSCNLKALKFNIDKNYENHINGNTKILAKINESQICEDHDDNRQILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNJ3</accession>
    <name>A0A0N4UNJ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ac81-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3152</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000109">
        <property type="protein sequence ID" value="VDN53179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNJ3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNJ3"/>
    <dbReference type="WBParaSite" id="DME_0000947501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000947501-mRNA-1"/>
        <property type="gene ID" value="DME_0000947501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813816at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000947501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14937" checksum="5B6EDBCAF1A6138A" modified="2015-12-09" version="1">MEQNYLATDTDLYAATNIFSKYLQAKSDNEEKEIQCDIINENNCTSSTDVTRLSYKERLRWHLKEFCYKTSIHGVPMLENAPNNIYRMIWIALLLACAIVFVLQAIFIVAKYQRNDKNTIIELKFETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNP6</accession>
    <name>A0A0N4UNP6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10687</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001236">
        <property type="protein sequence ID" value="VDN60714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNP6"/>
    <dbReference type="STRING" id="318479.A0A0N4UNP6"/>
    <dbReference type="WBParaSite" id="DME_0000954001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000954001-mRNA-1"/>
        <property type="gene ID" value="DME_0000954001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000954001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29071" checksum="F1B4985063A52650" modified="2015-12-09" version="1">MWSEKIVISDIDGTITRSDVLGHVIPAIGGQWAHAGVAELYTRIKDNGYNMVYLSSRAIGQSHYTKKYLQSIAQDSKVLPDGPLLLSPTSILVAFRREVIDRKPEEFKIAALTDLKKCFPLKEPFYAGFGNRETDVVSYRAVGVPPEKILIIDKYGRVRRADKIGFEASYMSIAADSVDYMFPPLSPKTSPASSKNIAMSQKFIHLKSMSFTKPEKFSNFTFWRVQTGGFIQLDDKDLTEYENKRKNLGEKRKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNT0</accession>
    <name>A0A0N4UNT0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3249</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000117">
        <property type="protein sequence ID" value="VDN53276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNT0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNT0"/>
    <dbReference type="WBParaSite" id="DME_0000958201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000958201-mRNA-1"/>
        <property type="gene ID" value="DME_0000958201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000958201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9583" checksum="B1A52F4D13A81624" modified="2015-12-09" version="1">MQYHIFRYLDQFRDPLEMEGEVLKKRLRMSSVESEPKQPIYPDINYVENKKVLPAWIHSKLIKENSGSGRFFALWNNPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNT3</accession>
    <name>A0A0N4UNT3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3253</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000117">
        <property type="protein sequence ID" value="VDN53280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNT3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNT3"/>
    <dbReference type="WBParaSite" id="DME_0000958601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000958601-mRNA-1"/>
        <property type="gene ID" value="DME_0000958601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000090">
        <property type="entry name" value="Protein CBG07940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000958601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23774" checksum="B5E0B596C6870344" modified="2015-12-09" version="1">MGPLKAKSGRSNAWCWQWSEFILLEEATQILFGHFENTNHSDFVFYSDRLIRLVVEEGLNRLPYSKITVKTPSDSFYEGIAFSRGNCGVSLCRSGEAMEQALRQCCRSIRIGKILVGDDTQLLYARLVPDIASRRVLLLYPILSTGFTVIKALTVLLKTGVDEGNTLLLTLFATPSSIKQIMESFPKITILTSDISFIIPYYFTTKYFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNW0</accession>
    <name>A0A0N4UNW0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase A(2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10706</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001238">
        <property type="protein sequence ID" value="VDN60733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNW0"/>
    <dbReference type="WBParaSite" id="DME_0000962101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000962101-mRNA-1"/>
        <property type="gene ID" value="DME_0000962101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000962101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21593" checksum="02AF58ED53F705B1" modified="2015-12-09" version="1">MDNTIQDPLSDCKNQVSQACLLESDMFCMTRQMQLANGIFFHSIFSRVNKTKRFRSLREDRIKVLINILFSSSLACMSKNLFKRNYPDEELKFGCSAASDRLIAYCTCTEDFCNADSIVVQAKRIGFDDGAISSVLPLPTQENTVIESVATNDNTIEHWNEKVNSIFILSKKYFKLGVIIIYKNIGSEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNZ2</accession>
    <name>A0A0N4UNZ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3307</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000121">
        <property type="protein sequence ID" value="VDN53334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNZ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UNZ2"/>
    <dbReference type="WBParaSite" id="DME_0000965701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000965701-mRNA-1"/>
        <property type="gene ID" value="DME_0000965701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF2">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000965701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10256" checksum="C129364E180B4EB6" modified="2015-12-09" version="1">SHWTKGEPSDIVLSCEIVGLDPINKSNRTCDSANANNTRLIMNSSENVDFLVRTEGSCFTAIFSIAKHTKLCPWCASEATKTEVNIFNFSCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPF8</accession>
    <name>A0A0N4UPF8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS10764</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001245">
        <property type="protein sequence ID" value="VDN60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPF8"/>
    <dbReference type="STRING" id="318479.A0A0N4UPF8"/>
    <dbReference type="WBParaSite" id="DME_0000984301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000984301-mRNA-1"/>
        <property type="gene ID" value="DME_0000984301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863719at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044069">
        <property type="entry name" value="ZF_C4H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018482">
        <property type="entry name" value="Znf-C4H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058:SF10">
        <property type="entry name" value="C4H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10146">
        <property type="entry name" value="zf-C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51896">
        <property type="entry name" value="ZF_C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C4H2-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000984301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9104" checksum="BBBD747BE0253C9B" modified="2015-12-09" version="1">MSRIPPHHSFGLGPTSSVPKIDHQTPPMKVNSKIKIFQKMAVHTCQSCFQQIHRNAPICPMCKSKSRSKNPKKPKRKLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPU9</accession>
    <name>A0A0N4UPU9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10821</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001252">
        <property type="protein sequence ID" value="VDN60848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPU9"/>
    <dbReference type="WBParaSite" id="DME_0001000501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001000501-mRNA-1"/>
        <property type="gene ID" value="DME_0001000501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001000501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21233" checksum="01EE08C99A50EC84" modified="2015-12-09" version="1">MQLILTTIRKFNIIIFLFHSDININFFNGYFKIMEIFINRRSSNGFDDYKVAENCQKYPRLAENLCPSTCALCCKTLDYSCADLANCANITRAMCQTAGFYDALLRMCPRTCGLCRRPGADGCSHARIKELCQRSCNSLDCLSQTTAPALSVCRDERVNCRSRPDLCVGPYAAVYANQCKFTCGLCNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPY1</accession>
    <name>A0A0N4UPY1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3570</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000151">
        <property type="protein sequence ID" value="VDN53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPY1"/>
    <dbReference type="STRING" id="318479.A0A0N4UPY1"/>
    <dbReference type="WBParaSite" id="DME_0001004301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001004301-mRNA-1"/>
        <property type="gene ID" value="DME_0001004301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873923at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001004301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11896" checksum="D3CF5BBC33438A82" modified="2015-12-09" version="1">NQFQINKKNLAEPSEIDDKPKAEASVTISESKCNNEKLMDLISKNIVEDDPVESKRAIHKAALEEIQDSVIDIICSDAGFTYIVSTTEYCEAQKRRVICFIYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ16</accession>
    <name>A0A0N4UQ16_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS3602</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000155">
        <property type="protein sequence ID" value="VDN53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ16"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ16"/>
    <dbReference type="WBParaSite" id="DME_0001008001-mRNA-1">
        <property type="protein sequence ID" value="DME_0001008001-mRNA-1"/>
        <property type="gene ID" value="DME_0001008001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0001008001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17779" checksum="9E570AC7B90BDF1A" modified="2015-12-09" version="1">MQKKIEKKDLTKQNGNNESNDSLSSAIKINALPYGFFEIQLIKYFHQFGGVKRVRVARNAKTGNHKGWAFVLFKDRDVAKIAAETMNGYLMFNKRLRCLFLIYFWSFYFLYFLFFINIFKKLKTFEVFFITAHYFLYIIYLHSFVGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ67</accession>
    <name>A0A0N4UQ67_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000164">
        <property type="protein sequence ID" value="VDN53687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ67"/>
    <dbReference type="WBParaSite" id="DME_0001013801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001013801-mRNA-1"/>
        <property type="gene ID" value="DME_0001013801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001013801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14381" checksum="DE3480312066B76D" modified="2015-12-09" version="1">MAIRDSRMSPIQAGFRPGCDCVDHIITLRMVLKISNIYPPLGVDRTVHWRMMEEYDGVPEKIIRLIKRMSIYVYGEFIDKNWCLSRLCRFPYYAINWIMDTAFRPSRGIQINPEHHITDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQL1</accession>
    <name>A0A0N4UQL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Post-SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000188">
        <property type="protein sequence ID" value="VDN53822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQL1"/>
    <dbReference type="WBParaSite" id="DME_0001030201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001030201-mRNA-1"/>
        <property type="gene ID" value="DME_0001030201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001030201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13000" checksum="D51D587FDA8F52D1" modified="2015-12-09" version="1">MNVIVAPVIIMRKWDCDLEKEKQKELEEDKDKGRCGTRNSTTVDSSGGSGFLFHRRKEGNDEEDVAEGIAKDLMEHSPYSDRSSVATRCGCGMQTCRKKRGGFDVVELSCYFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR12</accession>
    <name>A0A0N4UR12_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS3933</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000222">
        <property type="protein sequence ID" value="VDN53960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR12"/>
    <dbReference type="STRING" id="318479.A0A0N4UR12"/>
    <dbReference type="WBParaSite" id="DME_0001047901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001047901-mRNA-1"/>
        <property type="gene ID" value="DME_0001047901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="165"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN53960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0001047901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25935" checksum="123D2490791A5A9C" modified="2015-12-09" version="1">MNNRTRSNGIVPISFLEIKIPLPSLETNQSSKHFDVFYVCALYDYNSGIEGDLKFHTNDVIRVIEIVNNDWYRGELNANCGIFPSSFVQRAELNGSKTNTVTALYDYNSGIFEDLIFRKGDVIEVVEWISDDWLRGKLNGLIGLVPTTYIKQTQQPKMGAKSTKFCSYIVTAKYDYLNSSSDHLCFSKGDKIEIIEEIDENWLKGKLLLDMPNMKSLPSGLLPREIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR96</accession>
    <name>A0A0N4UR96_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3997</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000242">
        <property type="protein sequence ID" value="VDN54024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UR96"/>
    <dbReference type="STRING" id="318479.A0A0N4UR96"/>
    <dbReference type="WBParaSite" id="DME_0001056901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001056901-mRNA-1"/>
        <property type="gene ID" value="DME_0001056901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10633451at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229977" evidence="5">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="71"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001056901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45344" checksum="78A76BA89526CCA5" modified="2015-12-09" version="1">MCIAKKWLTLFYAIFLSTANRLVVFLNENNRSMFNAIAAYHGFANITIFERDDKPGSVPKTVCQRLTDENIIVYGPETYPANLLTANYAGLYSVPHFYLQPIDPLNIPKSKLSSRKILLSTNAVQKRRIGDMAADVQNSMRIDIPCSEDSLREKEISLKNITAADSALLRTIDLFPTPRIISNVLISIVNHYKWTSLVLLYRNASDLTDLQHFVAESHFPRSIQIIMRSLPTKNRYRRLLKEIRDLDEMHIILHADTNAIIPFLYQAYQQSMCTSPYHYVITNYDAMTLDLSVHPIDACNVTVVSFIDIRSKEVAALRTHLQKFNITIPQNSINVEAAVWSDSLALLKSVLSRADRMNLAAEEYSFCDRPHPYGERIISSLVKARVKNSITGPIALNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URU6</accession>
    <name>A0A0N4URU6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4181</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000367">
        <property type="protein sequence ID" value="VDN54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URU6"/>
    <dbReference type="WBParaSite" id="DME_0001077801-mRNA-1">
        <property type="protein sequence ID" value="DME_0001077801-mRNA-1"/>
        <property type="gene ID" value="DME_0001077801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039269" evidence="2">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0001077801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="9642" checksum="84E483834EB1736D" modified="2015-12-09" version="1">MVMLTFFLLLSSLSNHANGGAVEIDVCHMLVPVPQQGAGPGVGVGPGAAAQPGSVRRPTVPVESCQDRDAPACSEIFKYEAGEIRVLADNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US42</accession>
    <name>A0A0N4US42_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome component Ecm29 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4268</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000538">
        <property type="protein sequence ID" value="VDN54295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US42"/>
    <dbReference type="STRING" id="318479.A0A0N4US42"/>
    <dbReference type="WBParaSite" id="DME_0001087401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001087401-mRNA-1"/>
        <property type="gene ID" value="DME_0001087401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001087401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38122" checksum="E5BE42E27C8DD8B0" modified="2015-12-09" version="1">MGLKRIQPVDRINILPLLLYTFKKILENKESQNNKKIIDQLLCLTVESWISISQICFEKWPKLEALQCISVRKKVLLFMQKLIQFPHINGEAFVETVASDNCSNELGSLLPGDYNLIGKEIIGVGTSIRSAKMAIVEILSTSLFKKVEIFPLLALASGSDFIEIKNAANDSLKKFDIDEILKEKETITKLFKIYLGDEPNNIQPITSASVKIVILKLLVRSKIAPKMFTDNMKVVYDGLFGEHRTRDPSKLLQLSAEFLFLQIKNCPSSAQQTLSPIYFSTIKKLLNDDERWSATAAICYRCMAEIGRNNKSLVTSDFVLVQHLFDIVGKIGYARDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2T2</accession>
    <name>A0A158Q2T2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5139</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2T2"/>
    <dbReference type="STRING" id="318479.A0A158Q2T2"/>
    <dbReference type="WBParaSite" id="DME_0000077901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000077901-mRNA-1"/>
        <property type="gene ID" value="DME_0000077901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000077901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40217" checksum="0C2AF38E607AB256" modified="2016-06-08" version="1">MARRHYRHHHRRSKVTRVVNLVKRIIAFFFSHVGLCALVVGYALLGAVVFRAVEGPHETFIQSEVTTARQKAVNIAWNATFRVNKLDRNKWERTVHSQVKNFQHKCIWAIKRGYDGKEYGLSAQWTFTGAFLYSLTVITTIGYGNTSAKTYFGKTLTILFAIIGIPLMLLFLTNIGDIMAKIFRFLYARSIRLKYRLILWHKRRKAAELRRANSLMSRLTRTDLAFDSLGAAPDMHEFLTARAQLDQIEVKESVEAQLQRISVPLSLVFLTMFAYLVTGSILFCLWEEWTFLDSFYFCYISLTTIGFGDKFPGASVGNDKDAQEKLVITSVYLLFGMALLAMCFNLAQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3K2</accession>
    <name>A0A158Q3K2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3K2"/>
    <dbReference type="STRING" id="318479.A0A158Q3K2"/>
    <dbReference type="WBParaSite" id="DME_0000257001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000257001-mRNA-1"/>
        <property type="gene ID" value="DME_0000257001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852419at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000257001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20042" checksum="BAF7A1D572195B78" modified="2016-06-08" version="1">MKCAERESNILQQSCAVNSKQSVCGFSTPMEFLNWIRKSPSYSTVELAGKNSNAAWHHRRLLLHPLYTHPRRFYHLAGGHQPIITEKHVLPYLRRPSLPLPGWTLRHYSTLPLIYARPSTVDRYGSTAKIYPMDDWTERINNCLDDIGRTARSMNRWTQIKPENRYNFSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q440</accession>
    <name>A0A158Q440_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS7951</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q440"/>
    <dbReference type="STRING" id="318479.A0A158Q440"/>
    <dbReference type="WBParaSite" id="DME_0000394601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000394601-mRNA-1"/>
        <property type="gene ID" value="DME_0000394601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6147412at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000061">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN57978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0000394601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43850" checksum="05536FEEF516B754" modified="2016-06-08" version="1">MRSHKKCIERRILLLRENIKQEDILLSVLPRHIANDVRKDIAVEGQASTMFHKIYIRKHDIISILFADICGFTNLASECNPEELVHLLNKLFARFDHLAYRNHCMRIKILGDCYYCVSGLPEYRSNHAQCAVEMGLEMIEAIKLVREVTGVNVNMRVGIHTGRAHCGVLGLKKWQFDVWSDDVTLANHMESGGIPGRIHITEATLKCLGDLYKVEPGNGHERSRYLAEHNVKTYLIVNDDQRAEFIQQSNNVPFGEKGLRITGYVGERMYKRGNRDQRESCFALNCIAHKFNSYPFYRRVIEQPKPLDVEVENYLMQGIRAISKETWKSMYCKPFTLIFRKKKMECKFLELKDDAMVIQISCALSVFVICSIVLFINDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q456</accession>
    <name>A0A158Q456_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like_fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS432</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q456"/>
    <dbReference type="STRING" id="318479.A0A158Q456"/>
    <dbReference type="WBParaSite" id="DME_0000406801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000406801-mRNA-1"/>
        <property type="gene ID" value="DME_0000406801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000406801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="63646" checksum="63F2C359837EA465" modified="2016-06-08" version="1">MSFCDLYESCFKSISIIRIVDSNKDLNNSDDGELTVLDNVISTSKYILFYLLSANSERAKELVLPIKQFLQCRQENGTTNNTKSPPTRLRRFFGVGKKKHKKMKTVEEQKEISVIIFDVDSSDDNQQQVIDECGWYILAPMSPMTKSRFLRALRYCSTPSLIVVDSTSRQIITTDGRRLLQEDSKGNNFPWWNPTADELFQGTVLKNVIETDGSRNVSKIEYKDLEPVVKGIYFGAFWCPPCRMFTRQLLSCYESLKAASIPFEIFFCSFDRQKYFKTSVDFRSRESFDQHFSTMPWLAFDFNPSKLTLFTRLYNVNGIPALLILDEKNCVITRHGRNSMLNDPQGKNFPWGPQSIYELNEYTLCRLRDEPSLILFTEGSPEDVNFSIEVLKLTAEALYAERNESLKRSASKDNESQDENGDGSDSANFTHSSNSVESVASSDIGLPLWSDPLQMFYTGDDPVCDLILEGLGLADAELPLIIIVDVIVSRMVICTKPDVSSEIVANFVADYRGGKLEMVPLPSSCQSSPLQVGGIPIRAIHQALGIGNSPSQNSINNENTSVQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q479</accession>
    <name>A0A158Q479_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8079</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q479"/>
    <dbReference type="STRING" id="318479.A0A158Q479"/>
    <dbReference type="WBParaSite" id="DME_0000419601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000419601-mRNA-1"/>
        <property type="gene ID" value="DME_0000419601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22674">
        <property type="entry name" value="FHA_PPP1R8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000419601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36268" checksum="2154EC2DCAC8717F" modified="2016-06-08" version="1">MKTSKIGELNARNASMNSSLNDGSEAISKYEIPAWKLMIDEKKAYYFGRNPKQCDFVVEHASCSRVHAVLVYHQHLQRFALVDLDSCHGTFVGKVRIDPLQPVFIEFASVFHFGASTRRYILRGKLENANDEDELNKDLLPQEHELENLTEYNTALNRRIPAIPISLEDSRRKKRPRGNVAFIEEETIINPEDIDPTVGRFRNLVATAIISTKRKSEDGSKDEEPKEGPTQKKILRPGRVDDYNSTRYTSPMVSSLSIVMNAAPDLELYAKNLPEPSSGHVTPFAHIVSRHEDEDGDAPHKKKYAKESWPGRKPTQSGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4J9</accession>
    <name>A0A158Q4J9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8867</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4J9"/>
    <dbReference type="STRING" id="318479.A0A158Q4J9"/>
    <dbReference type="WBParaSite" id="DME_0000506801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000506801-mRNA-1"/>
        <property type="gene ID" value="DME_0000506801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000506801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28306" checksum="D0BF8EDE385951D6" modified="2016-06-08" version="1">MNSQLMVADILSDVNRKIGKKRKKGEVANPANTLDGLVAKRSIMKRYLTEKEAIEAPSEYLEMIRTETDPDVSTRTCSICGYQGKWVSEMIRHKRVHTNDRPFKCKYCSRTSKWKADLIRHVAKTHGIRVVSKYSRSKTFDSSLVHDCHETKSQCGENRDRCNEESIVALISHLQNVHNELPYECLSCNQKFNDADLAMAHCRYIGNSEAYANIATVHNGNSISCRDTSRCSLSMLKINVIPIFEGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4W0</accession>
    <name>A0A158Q4W0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MyTH4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS9383</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001181">
        <property type="protein sequence ID" value="VDN59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4W0"/>
    <dbReference type="STRING" id="318479.A0A158Q4W0"/>
    <dbReference type="WBParaSite" id="DME_0000585901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000585901-mRNA-1"/>
        <property type="gene ID" value="DME_0000585901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8182952at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="7">
        <location>
            <begin position="42"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="202"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN59410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000585901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47743" checksum="143A53951C245B47" modified="2016-06-08" version="1">MMEFAMLYFRRPKNISNVGDSLTTQRKKKEWTWKDISDKVKYTERPISHSLLRLDSNEADKLAQDAFLCIMRYMGDENLKRGQTFTDCVYELLMICHQYHALRDEVYCQIIRQTTSNKSSRSDSLIRGWRLFSIVTAYFDCSQVLKPYLFKHLIEMANDSRRAYHGTAHICLQNLAKTFKYGGRKFLLSGREVEAITTGKNLKRQLYHLPGGHKKVVNTKAVTVVEEIIQELCLELNIRSPTEQQEFCLCYILEIENIMKLLSNDEYILDICTELEHKKKEYFLLLKRTVWIHPLRLDNILYIDVMFFQIVPDYIEGLLIAPKPATLSAAFLEEVSFIGALLHLSDCNEQTKVSPQNAMNLLPKTIVTMRSGEQWAERINHKLCMIDANMNSTEARAKFLGSFLVQFYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PB28</accession>
    <name>A0A3P7PB28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000010">
        <property type="protein sequence ID" value="VDN50950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PB28"/>
    <dbReference type="STRING" id="318479.A0A3P7PB28"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="220" mass="25775" checksum="A127A371DC4E6B4E" modified="2019-02-13" version="1">MQFYYSLLTSFLSFFMTKTSINGVLNRGRMFIFSSQNFRNFLQIPHNWIAADKFMMAWRLQQKGFLVLPVDDWKTRGPFNLVSALNLLDRHYDPLQLLSDLHEITSKSDALLLLAVVLPVRQYVEFHPKKKTTLPDTKLPIYGLTFEEQAVSLVYFLNRMGFELVRWGKLPYLCEGDFNRAYYVLNDGIFLLRPIAKELTSKNKTETTRSFHISHDFNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PJT4</accession>
    <name>A0A3P7PJT4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS6487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PJT4"/>
    <dbReference type="STRING" id="318479.A0A3P7PJT4"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF23">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="155"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN56514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="466" mass="51692" checksum="74700AFBCDE3700B" modified="2019-02-13" version="1">MVGDESESDAENRFNTFDPLIKIRCSSQLKFFLCSVYFPMCTDKVPIAIGPCRPLCERVQMKCEPLLKEFGFPWPPSMNCSKFPLENNHDAMCMKGPTSDEEIPIANEEPEYEQVENNIPSTTMRCTQPNTIYMNRTGHCVPLCQSNHGYTTEDRESASAALFIMSLICIALTSVCLLTFCTRRNCLTALPELSLFFSSLSFCISAIIYLFSLLYRNQISCMVYTSKSVFVVSGMQHIPCTTVAILLYYFGTTGRLWWFFLCCTWNKHAQRNQQHLDALVLRSHVLAWGIPLGAVMLALMAQSIYADPLSGICLVGGGNRVIEVVFISLRELILLLCCLVPLFFGCLTLIGSAPANDHSVASSGLLGSIYPMAASFLLLSSLQYLLSPNISGWNTVTAVKLLADPLLGVLSSAGCLIQILFNIFKANRSPLLGKYGYQPAVPQIPQPPIPVSAYSVARYQEQRPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q2P6</accession>
    <name>A0A3P7Q2P6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS7716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q2P6"/>
    <dbReference type="STRING" id="318479.A0A3P7Q2P6"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN57743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="296" mass="33977" checksum="ADF264835F4FA1A8" modified="2019-02-13" version="1">MIWHCAEEQLSTDVADIVPKKSHNSERIVDTNSDSVSDSIGPKYKRLSQRMNPIIKKNMLNEKNERTIFVGNAPLTMTRKEVKKLFIKYGRIESVRLRSVIPNKKNLSKKVCLEYKAFYFFTYRYVIFSQSRIFFFLRNGGKVGSHHLRVDLCSAKKYYDCKNTVFIGNVPFNAKEDELIDHFSIAGDVSFVRIIRDPHTGVGKGFAFVSFSDSSSLPVALNMNGIAYEGRLLRITRIQKKSKQCTSNANSGKISRKRKNVANALDNLYGNRRSRRRIKISKKKRSKKIISKSIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q330</accession>
    <name>A0A3P7Q330_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q330"/>
    <dbReference type="STRING" id="318479.A0A3P7Q330"/>
    <dbReference type="OrthoDB" id="5859291at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="165" mass="18697" checksum="CF8A72FE090FFB7A" modified="2019-02-13" version="1">MTCLIWLMESGSTQGRLSKNLSIVEGEECDANSEIGTNTPEACIVKVDASDSIITNRGFSYFRECKRLEELKMNFCDFFGDDGIRELALGRPALTLKNIEIVCNPMLTDSAAQWLVKLRALQRAHFYFLPYVVNRTAMLRVLRLNLPKCKVTFPELGKIGYGYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QAV3</accession>
    <name>A0A3P7QAV3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QAV3"/>
    <dbReference type="STRING" id="318479.A0A3P7QAV3"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="306" mass="34918" checksum="F3EC753D56C2DEEA" modified="2019-02-13" version="1">MTELDLVRYEIINDESRLTEIGLSTELLENTIIFKILIFTAIGLWYEEICGDHPREFWYTSVEDAKKLGIEGTSLICDPFIEELYPSKKRLMQLSKKLNEIVQNTVDQNAKLNNLSQIVFKEIFSDGNFSLFDEILFAAKALNLNISKKLFERHEKIALWLSGICADYVPTAVDEFDATAFQGVEIDGPIGINITALEIAGVNLTELAEKLRNDTEVDELLARTTDSTRYFNSFIEWNKKDFKCNNSRTLGGSFILPVLQKNQYDPFSAPIVFQGSAVVVRFGIYIESMSNFHTETMVNFKKKKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QCG6</accession>
    <name>A0A3P7QCG6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYYG01000084">
        <property type="protein sequence ID" value="VDN52867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QCG6"/>
    <dbReference type="STRING" id="318479.A0A3P7QCG6"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="115"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="258" mass="29554" checksum="D2F36D5B022595D6" modified="2019-02-13" version="1">MRNFFKGDEEISKLYCYYKQDHPYLLLAPFKVEIVRFDPLAVIFHDVISNEEISIIQEVSHSRLERAQVVSPATRRREPASFRISKNVWLENNEHEIVERLNRRIHLMTNLDLKFAEDLQIANYGIGGFYDVHYDFFGKNSPLLESLPEGNRIATVLFYMSQPEIGGATVFIPIKTTVLPSKNSALFWYNLARNGEGDHRTQHAACPVLVGVKWIANKWIHEAGQEFLRPCGLKETDQEAFVGDLGGPVPKDHANIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QDU1</accession>
    <name>A0A3P7QDU1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS3230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000115">
        <property type="protein sequence ID" value="VDN53257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QDU1"/>
    <dbReference type="OrthoDB" id="5873877at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="447" mass="52067" checksum="67D43B598E58C7E4" modified="2019-02-13" version="1">MHFSKITFTASSVYDPFGKTSFIELNKQRRGHYERPSREKIYNRPPPPVKKIYLRKNGDINYRPKLFIWRIWLIPRLKELIEEAGSFVGIEKGETLHLYDYQGSEITNENDIRDGMLYVVAGEEDFDMRSSDLPNYVNTVRSAPNVTSTDSRSANKSRVNLMNGSVNFPEKEAVDPLQSNIATENNNDPYCVVANSPNKKRYFNVPPVPHEPLVSNYGYEDRYGDFDNCDIFANGDRSRTRKKHNFTGHGKPTVKNQSIMRESGEEIGELHGRKRGMNPNHKMTNGAARRSRSEVIYNRKDQTHPDVYIIYVFLNGQGMESQYINFKRSQLEKGMDFILELIARRFSVKPSRLCNMDGKKIHRISDMMSRGAYVLVPIGQAFRETWYFLPDNAIDTRSVLLRLNKKIHSDAEKIMERNNQRDRLKQLRERHRSKVRASMARTRQQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QNS3</accession>
    <name>A0A3P7QNS3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QNS3"/>
    <dbReference type="STRING" id="318479.A0A3P7QNS3"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="429" mass="47673" checksum="3D4E0562FD8096C4" modified="2019-02-13" version="1">MNILFGFIPILHWLPKYKIREYLLNDLIGGFTVGIMHVPQGMAYASLAGLDPINGLYTSFFPPLIYMFFGTSRHISLGVFAIVSLMVGSTNIRVTEEINQFAITQNLTTLVDGLRYVVTALTLCVGLIQIVMGLLRLDFLTQYMSDQVIKGFTTGAAVHVFVAQLNKLIGVPLSRHSGFGKLFKVIRDLYEELSSANMVTITISTINIIVLYVCKNYLSVRLKKVSRIPVPFDLIIVIIGLIISKVLQLETSYNVQVVGNIPIGLPSPAMPKLSLFPYIWSDALAISIIVIVVGVSMGSLFAKKNNYAIDIRQEFYAMGLTECGSSLFPCWPAATALARSVIYESAGTKTQVHAIILLRIIKLYFLVCILSSVIIVALKGIFIQFLELETLWLQSKIDFVSLSLYLFIGNHRKALNHLGSLFHILRHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SAP1</accession>
    <name>A0A3P7SAP1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000020">
        <property type="protein sequence ID" value="VDN51412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SAP1"/>
    <dbReference type="STRING" id="318479.A0A3P7SAP1"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000002">
        <property type="entry name" value="calpain-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF419">
        <property type="entry name" value="CALPAIN CLP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="115"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="579" mass="65709" checksum="2D40186C8847E426" modified="2019-02-13" version="1">MIGKAAHKFLGIDPQTGRIIGAVAGNVIFSLGGKDNKLSDIGKIILDNIISGNFKRKVRFLLIIHFAFLDHTLIVQPFVPHDPEPVPRPTPHPRPSDAALDFYDERDRCLKSNTLFEDPEFPANDSSLFYSRRIDRYIEWKRPGELVRDPQLITEGQSRFDVIQGELGDCWLMAGAASITLRDELFYRVVPPDQSFTDNYAGIFHFQFWHYGEWVDVVIDDRLPTSDGKLLYMHSRELNEFWSPLLEKAYAKLHGNYEALKGGTTSEALEDMTGGLTEFVDLKQPPKNLLQMMFRGFEMSSLFGCSIEASPLEFEARTREGLVKGHAYSITGMRMVETQQGTIPLLRIRNPWGNAQEWNGDWSDNSALWDYVSSEQKRDMNLVLAHDGEFWMSFQDFMKHFDKMEICNLGPDVMDEVTEMTGVSMSQAGYKTWNARTHLGVWSGQSAGGCRNYLNSFAYNPQYCMTLSSADPNDADGLCTVIIAVLQKYRRELKPKGIENLAIGFAVYEVDDYRGRLGRSYFATNKSIARSAAFINLREVTGRFRLPPGIYVIVPSTFEPGEEGEFMLRIFSNVVVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SBS0</accession>
    <name>A0A3P7SBS0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SBS0"/>
    <dbReference type="OrthoDB" id="5837977at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="76" mass="8321" checksum="C1752695219D545D" modified="2019-02-13" version="1">MTGLLPCYGVGMGVAMMMQQATSLTGSSVVLDAQALENHIRRAKAEGRTVTIVNGNLYIDYNFFAQIPPYFDMKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SPH9</accession>
    <name>A0A3P7SPH9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS2682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SPH9"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF95">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="236"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN52709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="837" mass="95926" checksum="32F787CB2B07039B" modified="2019-02-13" version="1">MRKYFFLRVMERSFNIFSIFSVLLSLKIPFTKVQDDVQRGYSLPNARSIKEFQRFRLFNDGLDPIIVFALVIAKDDGSMSRIEYLNETVNIIDYVGENFAIKNITYNDICKNFCDANEAVRQFRNGMILNENAENFNTYDFINASFPIMHLLGRGLDLTPSFFGVQTYDPSEMKNSTTTNIKDLKVIVLQFRAQQPPQWTFKAKCTEINISIVKVMVFTMTFTQDEVVRTGMTLAPFISFGFVIMLIFSVTTVYINTIYIKQWSFYKAFYAIFGCICPLFATSAAIGLLFFLGLRFGSILFVTPFLILAIGVDDAFLMMNAWNRILAYQVEHRLNFEIRDMIVLIDVGPSITITSLTNMLTFGIGACISIPEIQILCIAIATAILFDYIYTITVYTSIMTIGGIYEIRQKNFEIYREEKKKNKVSIFFDSYCEWLSSGFTSLFLFIIIIIYWIISIRGALSAKAGLTPEKLFLSDSPLIEMNAIRDKYVLPAYTFVNIFVNNPGNLNDPKRVSIIKEMISEFEAMPECNGAEFSHFWIRDYEAYLTNEKLEDDFFKSSVAYSIEDLQTFFNWPEYQHWGGFVRLNYTEKSFFATVAFHGENQADWIQKLHILKKWRNIVDSYTDLDASIYNDEAFFTEQFETLIPTMIQTSLIVLVSMAVACWIFMVNICNVIVAVAAIISICIGVFGLLSLWQIDVDPISMATMIMGIGLAVDFPAHITFHYYRSGFDKRYSTAKERIAHSLITIGFPLLQCSGSTIFFTTCLLLIPCYMSEVFVKSIVLVISLGTIHALVIVPALLCSLSNIYQNLISPNDNKVFFHRNQLFSNFLFYLSLFTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SSR0</accession>
    <name>A0A3P7SSR0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phosphoinositide-dependent protein kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS6985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SSR0"/>
    <dbReference type="STRING" id="318479.A0A3P7SSR0"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="370" mass="42858" checksum="288B05079F0E5930" modified="2019-02-13" version="1">MEFMHECSIIHRDLKPENILITAKRHIMLSDFGTAKIIGAEVGMTSTIDHKSDRNNSFVGTAEYFSPEALKDWEIGPACDYWALGAIIFQMISGTPPFRGINHYHIFQRIQKLDYSFPSGFPELSKDLVYDPKKRLGSNEMAHNFFSMIEWENLPSMTPPPLKAYVPASAGEPAYHSDFINPEDIEPGFDSATKSRLMGASVKEFLSQLVSFFNLKSHVLLSRAAIEAKQAERQRRLEEQNQNNPYHHIVGERLILKSGLLIKKKGLSYRRRIFLLTEGPHIHYVDEATKEHKGEIPMCKKLRTEGKNFRAFFVHTPYRTYYLFDPAERAMEWCDAIDDLRNRYMDILPETSDPPKSKRYRVLFLDKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0I7</accession>
    <name>A0A0N4U0I7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4429</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0I7"/>
    <dbReference type="STRING" id="318479.A0A0N4U0I7"/>
    <dbReference type="WBParaSite" id="DME_0000006901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000006901-mRNA-1"/>
        <property type="gene ID" value="DME_0000006901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF185">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000006901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21148" checksum="117219F5EA939380" modified="2015-12-09" version="1">MNATSKAGQSGRRANGNLSHASTNSTNQQQKNPKLYKTELCRTFADTGHCNYGDRCQYAHGESEKRPVPRHPKYKTAYCQSYHQLGYCPYGPRCHFIHSENSKLGQSRRSVGTDLNSLLLPARMQNGDFGATNHKLQNGSANALTSQNSMKSSDATPGSTTPVNENDNTGFGLAAWSYSGNNKVVSYCFIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0L7</accession>
    <name>A0A0N4U0L7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4462</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0L7"/>
    <dbReference type="STRING" id="318479.A0A0N4U0L7"/>
    <dbReference type="WBParaSite" id="DME_0000010201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000010201-mRNA-1"/>
        <property type="gene ID" value="DME_0000010201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000010201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41758" checksum="5FEA819E8F042AD2" modified="2015-12-09" version="1">MHFYLYNNSTVKCFKKGILWFIFYLALFRSHSSAYAPVHGYICVAICAFGIVTNLVHVLVLSRPNMRCSAVNCVLTAVAICDMGTMASYLIYICHFVLVKNPCSPMYSHLWVQFLLWHVVFSIALHTTSLWLVVAMAFIRRMTLKRTMLNSGWQQPKFAWKVCLAVYASVFVLCVPTLLVHDIIEYSADWRPPTRCASSYPENYTAKLYTLHVPESATANGCRFFKLNLWMSGIIFKVIPCGLLFFLSIGIVLKLHETRMKRKKLLDTKKIAAKKHSRKTDRTTAMLLAILVVFLITELPQGILAILNAIYTTHVHMYIYFHLGDILDLLSLLNSSINFVLYCVMSSRYRNTFWTVVLPSLIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0T0</accession>
    <name>A0A0N4U0T0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS4531</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0T0"/>
    <dbReference type="STRING" id="318479.A0A0N4U0T0"/>
    <dbReference type="WBParaSite" id="DME_0000017101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000017101-mRNA-1"/>
        <property type="gene ID" value="DME_0000017101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF22">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN54558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000017101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43047" checksum="17F1A373CA98FC94" modified="2016-06-08" version="2">MYVPTLSYSHVAFNGKLADLLVKSGYDVVLKLQAASEENFLSQTLWNNPGPFEDSSILNPRIIIKLLKVSSILLEYCRGSYNLLISFFYMQSAENNLIIELKRENFELGMIEQYDACGFGIFQLIGIKNIVWLSATAIYGPQPAALGIKYPLSYLPELLSPMDDRMSFIQRVENVLIATLSKRAQSIIANTSPLLDFPAPMSEKILHVAGFTVMKQKYILNKFWSQIANSSSEGFMIMSFGSIAKISQMDDRMRNIFFEIFRSFPRINFIVKYETIDEPVKKIEDNIFLAKWIPQIELMSHEKFIAIITHGGWSSVLESLIYSRPMILMPLFGDHFKNAQVIRQKQIGVIIDKNGMDKKFSELSEKKVEILAKFDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U130</accession>
    <name>A0A0N4U130_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-pyruvoyl tetrahydrobiopterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS4645</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U130"/>
    <dbReference type="STRING" id="318479.A0A0N4U130"/>
    <dbReference type="WBParaSite" id="DME_0000028501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000028501-mRNA-1"/>
        <property type="gene ID" value="DME_0000028501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14045at2759"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022469">
        <property type="entry name" value="PTPS_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00988">
        <property type="entry name" value="PTPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN54672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000028501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16311" checksum="34CA38FF48C3C032" modified="2015-12-09" version="1">MANQHPYVELTRIEKFSACHRLHNNLLTAKENKDIYGKCNNPNGHGHNYTWEITLRGPIDPRTGMVYNLSELKNEMNEVLDLVDHKNLDLDVPYFTDNVSTTENLVVYLWSELKCRMKNPSLLYKSVLHETDKNIFAYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U183</accession>
    <name>A0A0N4U183_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4707</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U183"/>
    <dbReference type="WBParaSite" id="DME_0000034701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000034701-mRNA-1"/>
        <property type="gene ID" value="DME_0000034701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000034701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40166" checksum="8E62B994DEAD2103" modified="2015-12-09" version="1">MNSESQNNAITVDEVLAKIRRTLCKNLNNSDTLALPSSSMVKVKLKSDKQISSCKFLLNENDGIKRAFDEAEINVIKNLLAAIPSGSEIIGNAVFEEIEDMTSTINDSAKPYSGHSPEGAINSLSESFANEHDFSTEFSITTENIPCLNIFGLENAIQKNIRFLKKSNETLAYSVSTMNSRQLSRSDMKFFKICHLLARVEWFELRNDLAEATVRKIEAILEESNSAYKEKRAKLKIMEDYNRKRRNELLRIDRIELLRKIDNIPFENLERELAIFREKIAEAEAETLNLTLKIRTRQTKMAVAKAEKYRKIVELLEKETMEKKQWKIVFYQSYEQQKRVIENKYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1F0</accession>
    <name>A0A0N4U1F0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4787</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1F0"/>
    <dbReference type="STRING" id="318479.A0A0N4U1F0"/>
    <dbReference type="WBParaSite" id="DME_0000042701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000042701-mRNA-1"/>
        <property type="gene ID" value="DME_0000042701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000042701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19053" checksum="0F7641772CECE42F" modified="2015-12-09" version="1">MASIDLFCAYAVMQTILYLLEILYITVRGATTGKGFFLRILGEYFHRTEPILLEIDQNDIVFFIDNDKTIQAISRRIRDDDRGTPCPVIIISKKAPVGFSAFGQAKNDLLKWVLNDCYNAETRILNLSNFSLGDQYRPITNASSERSVLGISPNFYQLSSFLHYFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2N2</accession>
    <name>A0A0N4U2N2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5312</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2N2"/>
    <dbReference type="WBParaSite" id="DME_0000095201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000095201-mRNA-1"/>
        <property type="gene ID" value="DME_0000095201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5808865at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000095201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12638" checksum="147C5F2C37691AB9" modified="2015-12-09" version="1">MDLINEKIRRKESRVASIGGTKIPWRYRSELVHEQKLDRPHFYIWIAIFISSFVGIAVFAKVKTDVIQERKKAMAEREKFRKELKGNVGAVENYIPLIAHWFLHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2N7</accession>
    <name>A0A0N4U2N7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5317</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2N7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2N7"/>
    <dbReference type="WBParaSite" id="DME_0000095701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000095701-mRNA-1"/>
        <property type="gene ID" value="DME_0000095701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000006">
        <property type="entry name" value="Double oxidase: two peroxidase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF133">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000095701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="951" mass="107795" checksum="056B792A5E8BB8BD" modified="2015-12-09" version="1">MLRHIVTDLSAHSNLLRLWLCHRSGKVLLADGVGCIESIFVIVIYTICYAIINQLSIFYNGKLIPLQCCSSNPNPECLPISVPVDDCISYSRTAPAPHPYCRLGPREQANQATSYLDGSRNSCSGMDGIDFNFLPSAAALHMLWIRQHNSIVINSKWTDEQLYEESRRIVVAQLQHVTYNEFLPLLIGREIWKKFGLDSESYGFSNNILRKPIHLPGLHIIKEFRRDLFKARNSRLSLNVASHIIQVGRDHGIPPYTVWREYCSGEKKTIDLIADIYENVEDVDLFVLGLAEKIVPGAIVGPTFACIIALQFQKASSIHKYFFILHYLYNLIKCNSVYFNYQTEFKPGDPLLSYGKMMRAKSEAVEIAKISSVLLETTRILMLGFSRFTGNFTVLLGPGGTVEKCLPKNLPCDHTTPYRTISGWCNNLRNPQYGNAFVPLLHLLPPAYEDGIDVPRSLSVTGVPLPSPRVISNTIHFDLPIDHSKYTHMIMQFGQILDHELTHSPITPGPDNQPLNCTRCDSHETISIDCMPSPIPEGDPHFPTYDENGERRCLPFARSLLGQLTLGYRNQLNQLTAYLDGSVIYGSTECESAALRTFVGGRLNFTSLGGANPSYNIWLLSGDQEQDCRSTPDYPCFVAGDERNNHQPGLTTLHNIFLREHNRIATILEDLNPSWNDQKIFLETRRIVGAEFAHIVYKEYLPKLIGNDLMSKYDLFPQSDGYYTAAFRFGHTLVRRFFSRFDKHYRNWTNPIDLVDNFNNVEAIYDERRGGIDSILMGLLGEPSMAFDRYITTALRNYLFARRDEPLSGMDLITINILRARDHGVQPYNAFREFCGLPRAKSFADLSVEMDDSTISSLQSVYNNVDDIDIFPGLLSERPIKGALMPPTMACIVAEQFRRTKRCDRFFYENDLTETHQLDEIRKISLGAVLCANSLLAKIQPDVFVLPDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2V7</accession>
    <name>A0A0N4U2V7_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS5395</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2V7"/>
    <dbReference type="STRING" id="318479.A0A0N4U2V7"/>
    <dbReference type="WBParaSite" id="DME_0000103501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000103501-mRNA-1"/>
        <property type="gene ID" value="DME_0000103501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN55422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000103501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="22592" checksum="3EA611CC897D3503" modified="2015-12-09" version="1">MASAMLKSFYIILIIFSAVIVCSKCAFLINGLISVLFYLLSGQGHRYDIGWFLTETSPHMWAGLGVAASLSLSVLGAGWGIFSTGASILGGGVKAPRIRTKNLVSIIFCEAVAIFGIIMALVFVGLMQPFNRSGASEEVIARNLAAGYMIFGGGLTVGFSNLVCGLSIGIVGSGAALADAANPSLFVKILIIEIFASAIGLFGMIVGIVQTNKAAMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2V9</accession>
    <name>A0A0N4U2V9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Scaffold protein Tuba</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5398</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2V9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2V9"/>
    <dbReference type="WBParaSite" id="DME_0000103801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000103801-mRNA-1"/>
        <property type="gene ID" value="DME_0000103801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27593at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11793">
        <property type="entry name" value="SH3_ephexin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="100"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="440"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000103801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="550" mass="63857" checksum="56FF10A2047E7ADB" modified="2016-06-08" version="2">MMEQQGNTIILDDDVDQVVILNQANNENKIIRRNSSSASVDSGRGGDYSTTVSHITSNTSMRRDRFIAASHYGSQRSLWCELPEVKNAGLLEKLDDKAKKLQEAFFEVITSEASYLRSLNILITHFMAAPELLGSKGISSVISNVERKHLFSNIFSVRDCSERLLCDLETRLESNLLLTDVCDILCDHFMGNFEPYVKYCSNQVYQDRTLKKLKFENSSFMSCIQRLESDRLCQGLDMRSFLMLPMQRITRYPLLVIAILERTPQDSQQNKNAHSALHLANKVVTDCNEGARRMERTEQLLDIERRLIYKSPDLKRIALVKSGRYLVKRGMLTQLLEKRAKNLLHSSKQNSRNIYIFLFSDIIMITKKKMLVYSSKILHLRKFFLFIPIFIYLYLTEYFFTKGRQIELLLNADSESDRERWLSALRPPCSNPEEKIYADWDCPQAITVHDYKAGQEDELCLTKGDLVNILRKMPDGWFYGERVNDGAGGWFPSSYVQQVLNDHVRAKHYRQRLRVIQQQSSSSVQRRHPHFIKRFRRLSNPKSIFLSNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U319</accession>
    <name>A0A0N4U319_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS5465</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U319"/>
    <dbReference type="STRING" id="318479.A0A0N4U319"/>
    <dbReference type="WBParaSite" id="DME_0000110501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000110501-mRNA-1"/>
        <property type="gene ID" value="DME_0000110501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN55492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000110501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="779" mass="89468" checksum="D4C76E872C8264FB" modified="2015-12-09" version="1">MDGDDADGMESFEIDDRDLEFALNPGSYRSLSKNQHLYGIWADREESDDENGSRKRSKNYSAPVSFVSGGIKHGNKIEGEVIDQEPIRFEKRIRQQRRAAGANVLAGMRTSSSHGTIDPEKFADWAKHSKSGVIMKMMTNMGYIPGQGLGAKKQGIVEPIQAVVRPGRAAVGAYGKEAKGPNFGESAGNSQKRMDEGHPNDSLSSNAEKRGNWKKNNSKKVLTIRYKTIDEVLAEGGNLKNLQKRADLSGSGVKVIDMTGKEQKIYSGYDAYAAKARIVAEEHDEKLAFDVPELTYNINMLLDMTEETIRRTDHQLRFLYDQTTALENDRDQLKELLINERNEGRRMNEVLALLQRFTCADSDPPTLAACYNLFEKLQTEYFEEYRLFNLEEIAIATVLPLIQKHFSTWNPLDESQTNYGYDLIITWKRILEKEDQGVLTRNLTPFERLLWDGWMPNIRRSVLKWNPRDSIYPMLKVIEKWLPLLPLWLRENLLEQIIIPRIASQVDEWNPLIDRVPIHTWLHPWLNIMGDRLHSIFAPIRQKLARALVEWHPTDQSALSILRPWKGCFASATMSAFLAQNIVPKLDKALREMIYDPTKNQRYDEFYATLSWSEMLGTEGVAAILVRSFFPKWYETLCTWLNSPRVLMDQVAMWYNEWKTRLPMEISSLPVIREQLTRALMAMNQAQQGVNVPMQPLPPPEPPSFVINRPHSLFQELVEMRARSAGITYVPQPNKFKEGKPVYWFGNISIYIDRNVIFGFNVETQQWAPIGLDHLINIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3D2</accession>
    <name>A0A0N4U3D2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5592</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3D2"/>
    <dbReference type="WBParaSite" id="DME_0000123201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000123201-mRNA-1"/>
        <property type="gene ID" value="DME_0000123201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042763" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000123201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="22648" checksum="53DDA62FD4393574" modified="2015-12-09" version="1">MKYILGTFASILIDVCIAQLGYGGGGYCGTCAMKNSGVFSPGFGYGGAGYASSNVASPVAAYGYGQSQGSYGSYGSPSTYSAYPYSNYASGSAQSNLPYRQSSYPYAGTLKSLGSYSNSPYSNSVGSLGANSGLSGTSFGSYPPSSSNVMSYQPYSSSSNIASYPSLPSMYSNYGSNDPSSSDGYNSYGANGYEASIGYNTQSLGSVFPGYKHYRNKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4M1</accession>
    <name>A0A0N4U4M1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS6099</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4M1"/>
    <dbReference type="STRING" id="318479.A0A0N4U4M1"/>
    <dbReference type="WBParaSite" id="DME_0000173901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000173901-mRNA-1"/>
        <property type="gene ID" value="DME_0000173901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN56126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000173901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36530" checksum="1B5B85FD30473C0A" modified="2015-12-09" version="1">MEVLSKSNLPLDAFVTEIFELYYVTYYVTHQACNKGQPQEVFHSLENLFNEISYNAAPPFPFDPYQSSSNNYPIYDQSSFTLRPQTNFASQSVHTGPECPPFCDTFYGTFSCSDPAVRYNEMSLKEESGSLELPKNGKKSFKEEISEQTDVDDDEDDDERIGDKNDGQKEKKKRRKRRVLFTKAQTFELERRFCTQRYLSAPEREQLAMQIRLTPTQVKIWFQNHRYKTKKSLQDKGIHSNLLHSTTSSNSSSLSTARRIPVQMLVCDGKPCPSEFIGACQTHNTIQNSFACNGTYFSHTATFPSSTQYYMHNGWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4U2</accession>
    <name>A0A0N4U4U2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6183</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4U2"/>
    <dbReference type="STRING" id="318479.A0A0N4U4U2"/>
    <dbReference type="WBParaSite" id="DME_0000182301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000182301-mRNA-1"/>
        <property type="gene ID" value="DME_0000182301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000443">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000182301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14561" checksum="B6E1C87CD2107CC6" modified="2015-12-09" version="1">MAKTLKHFHINCSLWRNNFLQFLHERGGPPKRRSRSNDKKPISGQSCFKGIVLKLVIRHPKKPNSGNRKCAIVRLSNGKEICAYIPGVGHNLQEHSHVLVEGGRRRDLIAVRANIVRGKLDCAPVKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U535</accession>
    <name>A0A0N4U535_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sec3_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6299</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U535"/>
    <dbReference type="STRING" id="318479.A0A0N4U535"/>
    <dbReference type="WBParaSite" id="DME_0000193901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000193901-mRNA-1"/>
        <property type="gene ID" value="DME_0000193901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 coiled-coil" evidence="5">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec3 C-terminal" evidence="6">
        <location>
            <begin position="358"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000193901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="682" mass="79348" checksum="E1D1CFAE513C5897" modified="2015-12-09" version="1">MSILRFFQPISAKEEADFRRLLARANLTIGDAEKFASILTEQLQLLDGANIQSIMDSEAAVSDLIALIDRTLEEVNHLDEQLDAFDKLLYHVRDNVEIIEEKDSLGCVERKNMRILRDSLAEFLSVIEIVSEEHIKILQAANLSDPTNISRCCAAARAMQTFWAKKVHPSLNLMLAYKERTELLSELTDSFVEKFMAHLSALFFNLNELIDTPDCHDLVLRKQSERFHALRPFSDLIGWLKNVRPVAYQNIIQRYVQNTKEIYKKEFDRFFESLNYELQRISISERKSTGENAENLKTRDNKFDRQALINLTEIIFGEIGPVVGAEQKFCLRFFHISGEILASVDNSSSVIGDNVDRNPDKQMFDQIKYLLSSLFESLHDHFDKFIKKCCAIQPSIILVIFVLLSKKALGLQNSTCFFSVMVFGRFVVLVKRQFDIFMDYVSHYLMEVRITKKMKIGLLDSIDYFKDVALTAEEAFADAERRTDLDRWYCQLLASLKKGIERAATSQYSKSPFTVVRFENYHHLFSVLSELKIDFLDNEKREARKVYLENLELYVKNSMGRPLEKIHIFFENVEEAMRRGVKADEIAFHQQFSKSELKKVISLYPSREVKKGLNQLYKKAEKHLVDDSQLLQVVWRHMQEEFIKQIKHYIQLIGQCYPNSNIDLEVSIEDVLNYFSQFALEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U562</accession>
    <name>A0A0N4U562_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS6328</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U562"/>
    <dbReference type="STRING" id="318479.A0A0N4U562"/>
    <dbReference type="WBParaSite" id="DME_0000196801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000196801-mRNA-1"/>
        <property type="gene ID" value="DME_0000196801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN56355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000196801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="69807" checksum="53D16F82FCCB9A30" modified="2015-12-09" version="1">MYNISPKSAALLMRRREKIRNFGIVAHVDHGKSTLADRILESAGIFDSEHESQILDTLQVERERGITVKAQTCTMIYKDHLLNLIDTPGHVDFNYEVCRSLAVSDGILFIVAANQGIQAQTVTNFWLAFERDVTIIPIINKIDMKDVDLELVKKQMINLFEFNLSDFLLISAKYRTNIPLLLDAIIERVPCPKVDYNAPFRSLIFDSWYDKYIGAIVLVLVKEGSVTRGQKISSFLNKKEYEVHEVGIMHPNMLPVESLYAGQIGYIVTRMTSVKEAAVGDTLFDYSSKAVIVPVSGFKPAKPTIYSGLFPVDGNDYDSLKQAVERLALNDPSVSISGDSSPALGLGWRIGFSGMLHMEVFGARLEQEHKANVILTYPSIEFRAIIKDNQTVRKKRYEGKSEISVVDASKFPDPSDVEKFLQPMVKLTIIMPCKYLWPVKSLCKQANGVFNEVSYIDETRVMLQSHLPLAKVIVGFFEDLKRITSGFASFDYEHDGYEEVNLIKLVISINDKPVDEFSQVLIASQAKNRAQLIVQHLKKEIPRQQFEVIIKATIGTSSKIIAQARISPIKKDFTQTLKGNFGGGGDRFKKKLADQKDGKARLKLLGKVAIPKEAFINFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5F1</accession>
    <name>A0A0N4U5F1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6431</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5F1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5F1"/>
    <dbReference type="WBParaSite" id="DME_0000207101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000207101-mRNA-1"/>
        <property type="gene ID" value="DME_0000207101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF312">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="305"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000207101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="686" mass="77654" checksum="BA26D63898578804" modified="2015-12-09" version="1">MPVLLRNNLNLGGSNSQSRFDSHRKLSPDANSNHVDVNPTLPKLSSRRTISIVSFAHSPEKSKSKTRIQRLQLLYKKLKLHLLVPLLFIILYMFIGSFLFLWFEASDELKRKTHKYDLFVRERELFLKRMEEIYLDQAAAEINLRKLFTAQAIDYFHEQIAVSFSNETEWSLATALYYSGTVFTTIGYGDVACNTVGGRIVTVVYAIIGIPLMLITLNDLGKFFYAAINCAVKIVGEKNSSLTKFLSKGTDKPIDVEVGENNTVAENNELKFQLSTDDTTITLDEKQVAPGPPPRMPVTVAIGTTVGWIFFCAALFKIWENDWTYAESCYFMFISLSTIGLGDVAVKRRDLMVICFVFVIIGLSLVSMCINVIQAALEDFYIRILMKILLDYQRKLAEGDNRMGASVGMMQSWSNNRAAKYLMPLLSKDRRMLAMAKVQEDAEANGLEVPLIFSDIDEKSGLPKIFAPSPDIKETVMEDLLREISVKAQSLESSSQRAPILYDGTTQTDTTIWLINFLIENGIQTDLAECLNESVQTFPTQPEVTEDESQTDVSSPQDTRADSFKSILKFLYRGTFVCLSAKVSRLFIAVMVQRRSADPSVQVWDKIDELEDTNEEDEESSERLDWNPVDGMHAEKQKPVRALAKMFEIRSQNSLRSESLAQYRLKRNKSLSKEKSKSPRPGKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5V9</accession>
    <name>A0A0N4U5V9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6626</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5V9"/>
    <dbReference type="STRING" id="318479.A0A0N4U5V9"/>
    <dbReference type="WBParaSite" id="DME_0000226601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000226601-mRNA-1"/>
        <property type="gene ID" value="DME_0000226601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000226601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36550" checksum="E7F9169297DFABD2" modified="2015-12-09" version="1">MYISGPTGTGKTFTVQHFFSSISHLHRFELLNLNCVLFKMEKDILRFIFDKLTKANKQPNVSNLLECIENVFSNAEIPIIIVLDEIDYMKSKNNSFLYKFFEWPTKYSQVACIGEGVSGISNSLDLTERILPKLKLSHSPVRVIFSPYTRIEIQQILVNKLSHIGEVDMQAIELCSRKIASMTGDIRFALQIGRQMLFSSNEKENKYCERVLGTLSNIYDSPILRIRLPIQQKIILAVMLNLSQKYSTTAINKDLFEKSYHNGCKKLSVVSMNANDLSSSLLLLESQSVIQIKSSHYQLLIDAGTAAKIISDSTLISQFFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Q0</accession>
    <name>A0A0N4U6Q0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransf_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS6976</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Q0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Q0"/>
    <dbReference type="WBParaSite" id="DME_0000261601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000261601-mRNA-1"/>
        <property type="gene ID" value="DME_0000261601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF59">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN57003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000261601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="643" mass="73729" checksum="E715E71F893B4654" modified="2015-12-09" version="1">MYILPNSAKQFNDPCFWRKFFEKQKQPFECFFQLYDVGYRHITSIDTDEKIIEKQLNDNNGIRPELKFLCCSAMKVDIETECINVVLDKGTLDALLPPDCSEIDIAEVERMFTEIDRILIVGGRYLVVTLAQSHLLKILLKSFVARSNYLFRIQKVDGMNKKSKLPVFIIIITKLRSPLSSNIFEYIKADSGKACRLSSLEALQSVINSEQELAFFEYLCSKKLSEEVAILIYNDAGEVRYQISIVDNQKIHFPLTYAVFIVPIGREHEWLFGTEKGRMDLREKCLTDRLAVIFLSREQQYEDLEFIKKELDSFILKFAPPKLRHGHSRINYLSIGEYDVKKTVAKGNSSINGTWTVEDVEINGSLFRQLIFLSSRHLVQSQARLIKRKKSTIVDLDKLMCEHHNAMLIAFLFLSRQVLCSPQEATLRCFWQKSFIDRSAELEMILEKEDSYSQIVLGLGGGLLPSFLLRQFLKSSISVVEIDPSVKDIAEQYFSLPVDNPNLSIIIDDALNFIFQAQNKLLYDVLFVDIAGSMNVEGLNCPPPSFITAEVLTSMHNLLKPNGVMAFNFVTRDDAYGNEIIEKIKSVFGNVYIYSSNEDINKVLICPKENIDIASANKISKSLRRENDWRSNLAEEMCHLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6Q6</accession>
    <name>A0A0N4U6Q6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6982</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6Q6"/>
    <dbReference type="STRING" id="318479.A0A0N4U6Q6"/>
    <dbReference type="WBParaSite" id="DME_0000262201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000262201-mRNA-1"/>
        <property type="gene ID" value="DME_0000262201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826678at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000262201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13241" checksum="638362C5A913C29D" modified="2015-12-09" version="1">MSSLLFISTRPLTQNVMIRILSMRSASATAVPPPAKIQLPKPKEPGHIQYQRFWSRDKRYKPQVPGDTPARLLFGRLGHAYEIYPLLFLGFVWFCGFLVISYTSLSKIEVWIDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6S6</accession>
    <name>A0A0N4U6S6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">COPIIcoated_ERV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS7005</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6S6"/>
    <dbReference type="STRING" id="318479.A0A0N4U6S6"/>
    <dbReference type="WBParaSite" id="DME_0000264501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000264501-mRNA-1"/>
        <property type="gene ID" value="DME_0000264501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="219"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN57032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000264501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47937" checksum="F97953417CB07CDF" modified="2015-12-09" version="1">MSSLSLPTIRRRRNYVQKFIENIDSFNKATDEVLEEKKTTGGIISGISFIIIVILIFMQLNAYIFGEDDYNYKFSIDTNFSDHPYLELDMVVATSCSNLIAHFYGSLSEQFTVGPTLKKDPTRFDFTEKELYYWEELKKVHRQIRSDSGTHFNRLEKMAFVSQAVEEGLKSEADGKLLDQKRKNKKKKAIHHFEENAAIFFVSNGINVLHIVASGSQNMDSKACRIHGRVQVNKIKGDNIVVSLGSEIGIENLLAQFSGIPFEGNTSHRIERLNFGPRIFGAITPLAGTEQISLSGKEEYHYFLNIVPTKIYHNGIFGGHTLVYQYSVTFTKKVPKNTPDSHTHAGITIHYDFAPTVIEVRRVRMSILQLVFRICSAVGGIFATSSLLNGLIVYICDTYRKFIVSGADLLKTTKRRENLIFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6U0</accession>
    <name>A0A0N4U6U0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7022</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6U0"/>
    <dbReference type="STRING" id="318479.A0A0N4U6U0"/>
    <dbReference type="WBParaSite" id="DME_0000266201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000266201-mRNA-1"/>
        <property type="gene ID" value="DME_0000266201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000266201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33176" checksum="4D228875AFBB0790" modified="2015-12-09" version="1">MRKVDFRQTGHIHAVFREVFTGGSKGIGKEIALALVHQGCSVSIIARNAADLDLAVSEINALAKSVGSQATAHAYLLDVVDAFEAIENVVKKAEDEVGPIDILINNAGRSVQNAFDILPLHEFEAQLKINYLSAVHVTRAVLPSMKKFQRGTIVFVCTAAAECPIWGYTAYAASKCALRGFFESLHMELLPYNIGVSIIYPPNTDTEGFQEELKTMPKEVKEITGSGGIVSPKYVADCLLNGIANGKTNIYVGFEGWLLGLLSAGGAPESSFFQVVLQVLLAGLLRGIMLIYIGNFNRVVQWCRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7I0</accession>
    <name>A0A0N4U7I0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SMC_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS172</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7I0"/>
    <dbReference type="STRING" id="318479.A0A0N4U7I0"/>
    <dbReference type="WBParaSite" id="DME_0000294301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000294301-mRNA-1"/>
        <property type="gene ID" value="DME_0000294301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN50199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000294301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8914" checksum="BD8EF1B2FEBA4364" modified="2015-12-09" version="1">MALWETMEMPFRCMDEFDVFLDMNNRKIIMELLSDLATRQYPSHQFLFFTPQGLSDFAQRDRVKLFEMPKAKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7N4</accession>
    <name>A0A0N4U7N4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoprotein 3-alpha-L-fucosyltransferase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7163</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7N4"/>
    <dbReference type="STRING" id="318479.A0A0N4U7N4"/>
    <dbReference type="WBParaSite" id="DME_0000300401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000300401-mRNA-1"/>
        <property type="gene ID" value="DME_0000300401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF8">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000300401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35409" checksum="66A9B140A05F4A68" modified="2015-12-09" version="1">MRYSTSAYFLLSRTCRNATILLQISIGICVGFFIGFSLKYEYDTDIYSSINFDKSFVDHQRNNTSALINKNDINIRCVIIISQQQNRKSKYVATIRDTYSQQCDEVVYFTDSSELQKEFAARNATNNLPTWTFVGDEQIYLVVSNLKRYFKGKNHDLSLILGRLSNKRTLLSFLFPFGTYESISIKSGVVFSQKALVAFNDAKCSGLFFPMATEKALLKCVSIMGIYHVDPVDEENIHLFNTRDLNDLIRKKTLQPTMMNKERNLHADCCSDKGITFGSLTYKQQRMVDYMLRRIKVFGLMPVQSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U835</accession>
    <name>A0A0N4U835_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HID1 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U835"/>
    <dbReference type="STRING" id="318479.A0A0N4U835"/>
    <dbReference type="WBParaSite" id="DME_0000318101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000318101-mRNA-1"/>
        <property type="gene ID" value="DME_0000318101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000318101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79562" checksum="BB9E2AD9710213E5" modified="2015-12-09" version="1">MGGSNSKLNFRKAVIELTSKKTKGEEDAFWEELWANNVSKAADVFVLIPAEDVRNLRDNFPNNLAALCYKTVDRLTLACDSPANLNPNKVLNCIRLLTRVLPYLFEDADWRGFFWNTPPPQNNSQSINQPLAYTLLSTLADLLFCPDFTVASLSNRPSSDDLATLDSCEYIWEAGVGFATKISQNADHDSHRMEILKLLLTCFSEIIYAPETEGNRMRWISYFTSAKNRHVLPLFTSLLNIVCSYDPVGYGVPYNYLLFTDTREPLVQTAVQVLTVCLDIESQSTDNNSDEEDFEFMLKGFTRLLSNTILTTYLPNSIKKISFHQELLVLLWKCCEYNQKFMFFLLKTAEVLEILVPILYHACSARFDPARVGLIHMGVFIILLLSGERNFGVRLNKPYIPRTVIDIQPFTGTYADLLIIVFHKLITTGNCRLQSLFDCFLTIIVNVSPYLKTLSMVAANKLLHLVEAFSTPWFLYSTPNNYLLIFFLLEAFNNIIQYQFDGNANLVYTIIRKRQVFYQLSNLATDSESITKVLSSRKSRSKIDVVDSLKSSTSDSKEITSKSGTINTTLAATPQVLVMTEKDAHSSNLENKGGDDDNTWLPTTEWVESWKSKLPLQTIMRLLQVLVPQVEQICIDKGLTDESEILKFLQHGTLVGLLPVPHPILIRKYQANNATEQWFQTYLWGIIYLRYDCFYIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U885</accession>
    <name>A0A0N4U885_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U885"/>
    <dbReference type="WBParaSite" id="DME_0000324101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000324101-mRNA-1"/>
        <property type="gene ID" value="DME_0000324101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876442at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000324101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65692" checksum="9527C098CA8A77EC" modified="2015-12-09" version="1">MSVLDGYADARNSEKKSWEKGRNRNSEHFGEILPEISVGIPKSTISRILSIFCSYYSDGFGVTNKRNNHLSNTSVNASEHSRMASSNTERSSSVQIQTPSPSRLKRTPELAYKRIATNRVSHNIHLASDSDDGNQATSIIKDDDLGRNNRKPLPSENHANQNQLNAYPIFNKTTIINASANNTTMKAETFAEKKSSDLRLAKEAATNNHFGSVEIEIDDEGHSIISEKITNEHYHTSKTNSSNESPIIERQIPIKITHEAKEILENNARIFSQKPVDHHYYQKKSNISGDNTQTVDSSNNDQPSTTTQECDPLKRNTDYGSTISSLTQSSNIKTEISDIDFSWVNDVENRLEKEIAFMKEDYTRNQMPVRYFGIDDYTDEKFDSLSPSSKPTTNTSFSRNIEVFGNENDSRKELSEIHSHVKSKAAMFDNEALKAERNRFVTSQQGLSRLRARSTPRNDSTIFIPQPDYLRFDPISINTTHQDDSLRYFGRSQPDIHRLDSEEQNYKQANSNRYKVSDSTSNHLPVHYRQNNQLSRISDVKNEVLQGSRTYQTTEYYRQNAVRRNSEKPWRASVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U887</accession>
    <name>A0A0N4U887_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Host cell factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS7402</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U887"/>
    <dbReference type="STRING" id="318479.A0A0N4U887"/>
    <dbReference type="WBParaSite" id="DME_0000324301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000324301-mRNA-1"/>
        <property type="gene ID" value="DME_0000324301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000008">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000015">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043536">
        <property type="entry name" value="HCF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059124">
        <property type="entry name" value="Kelch_HCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003:SF1">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13854">
        <property type="entry name" value="Kelch_HCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="367"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="895"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="647"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN57429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000324301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113458" checksum="90B77B9E22464EEF" modified="2015-12-09" version="1">MDSDRRDPMVGTSFSNFPSVRWKKVTNTTGPTPRPRHGHRAVAIKDLMIVFGGGNEGIVDELHVYNTATNQWFVPAIRGDVPPGCAAFGIICDGTRIFLFGGMVEFGRYSAELYELQASRWQWKHLRVRPPKSGSAGPCERLGHSFTLASNQVCYIFGGLANDSPDPKNNIPRYLNDLWALDLKYGTNNLQWECPSTFGTGPSARESHAGVMFEKDGYRKLIIHGGMDGCRLNDLWILDLNSMTWSNPQPEGIPPLPRSLHSANIIGDRMFIFGGWVPLVLGDSKMDQIEKEWKCTNTLASLDLNSMCWETLSTEIYEDALPRARAGHSAVVINKRIYIWSGRDGYRKAWNNQVCCKDMWFLETDRPAAPSKIQLVRATICGLEVCWNSVPTAEAYLLQLRKYESTPRGTEDGARAVGMVRMSAAKSQISSNKLIAIQRSSGGPQVMKVVRSGPHLSSGVITPTSGGSLLRVVSASKGPQTTATSIPKSGTKTIIVTKATGTGTAARKLFLVQPSTSSGSSVGGVRSNTQLSLVDSVPQRISSKASSVAVVGSEHTSTISTHGTTYTSPMTSNVDTGLPQNLLDESLMETDSGMGQPDSVDQIQEPSDSYRTSQVVEFMPTEQASTSLSSETTQGLNDGVTPEITHDSEAPVEQKINQSSKEIQNEENEIKSTEDLLGLRNSDEIKENSDHVKENFGKQEIPADDMKESITESQNIESGDGVVPFFKVEAPESSVSDNLVNPSASESKSGENTVESSDNMPVSSTAPSVADVASENSVACDSKVTQTLKVVKVEATSTQNEPYPVKEDPPWFDVGIIKGTSCVVTHFFLPSDMPLEDTYSTDFEVGMHTSQVGLLRKAELEPGTAYKFRVAGINACGRGEWSEVTAFKTCLPGFPGAPSNIKVSKSVRGAHLSWDPPHNIGGRICEYSVYLAVRSSHMGNETQLAFVRVYVGPESSCVVSTTDLQVAYIDMASKPAIIFRIAARNDKGYGPATQVRWLQDQRQRLPPVIGRQSQPLHQPMVNDYHGISPVHIQAKRMRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8C7</accession>
    <name>A0A0N4U8C7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Peroxidasin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DME_LOCUS7451</name>
    </gene>
    <organism evidence="28 30">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27 29" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66020"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:16949"/>
            <dbReference type="Rhea" id="RHEA-COMP:16951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:166867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66024"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:16949"/>
            <dbReference type="Rhea" id="RHEA-COMP:16951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:166867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:66025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-tyrosyl-[protein] + bromide + H2O2 + H(+) = 3-bromo-L-tyrosyl-[protein] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:69360"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:17686"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:183512"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:69361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>bromide + H2O2 = hypobromite + H2O</text>
            <dbReference type="Rhea" id="RHEA:66016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:66017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>hypobromite + L-tyrosyl-[protein] + H(+) = 3-bromo-L-tyrosyl-[protein] + H2O</text>
            <dbReference type="Rhea" id="RHEA:69356"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:17686"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:183512"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:69357"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the peroxidase family. XPO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8C7"/>
    <dbReference type="STRING" id="318479.A0A0N4U8C7"/>
    <dbReference type="WBParaSite" id="DME_0000329201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000329201-mRNA-1"/>
        <property type="gene ID" value="DME_0000329201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09826">
        <property type="entry name" value="peroxidasin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000273">
        <property type="entry name" value="contactin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000001">
        <property type="entry name" value="Peroxidasin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000299">
        <property type="entry name" value="protogenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034824">
        <property type="entry name" value="Peroxidasin_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF140">
        <property type="entry name" value="PEROXIDASIN HOMOLOG PXN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 24" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 24" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 25" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039164" evidence="25">
        <location>
            <begin position="17"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="24">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00061342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="VDN57478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="WBParaSite" id="DME_0000329201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="949" mass="108832" checksum="78ED88C5390B3CEB" modified="2015-12-09" version="1">MLLSFILITTFRLTISNSNYEGQRLNRIPYFIKTPKNETYREGSSVELYCEAAGNPKPLITWTFNDTEIISSKKFITDDKKLKIFPFQQSDTGNYQCIAINENGEVKHDFQLNIRENAAPLIVDKPLSQNAQPGRRIVFVCRAIGEPTPQISWLFNGNEIDRSDLHISIGKNNTEYIIAHVTREDEGEYTCLATNPLGSSIEKATLKVVFPYQNHIDESLTDEAIKNIVNLAKSNIDRAIADTQMMLSKPNLSPAEFMQMFKFNTKLHNNDLSKAREIYEQSLLLAKEYIRSGLNLSVSELPTNFSFESTLAVSHIQTIMELSGCVTGPFRRPCTNMCFHSKYRSYDGQCNNLNHPFWGVAQTPFRRNLPPIYENGFNTPVGWDPNKLYFGFKKPNPRSISMKLISTDEITPHHEVLRCYGKISAHDIEQTAPGLARQTYMKGAICNKTCEHLDPCYNVPIPPEDPRMQKKKKPETPCIEVERSSATCGSGVTGPIYRQLTYREQMNILTSYIDGSGIYGSAEVDALDLRDLFGDHGLLRFDIVSNAQKPYLPFERESNMECRRNRSRENPISCFLAGDYRANEQLALLSMHTLWLREHNRIAAKFLEINPHWDGETIYQEARKIVGAMFQVITFEHWLPKVLGTDAYNELIGPYKGYDPEMNPTLANSFSAAAFRFGHTIVNPILYRLDKDFKEIKEGHIPLHEAFFAPERLLSEGGIDPLLRGLFAMPMKKPKEQQLVNKELTSKLFSRVEEKCFLMLFKTYLQSMYDLATINIQRGRDHGLPGYIEFRRWCNFTAVETWDDLAIDIPDRNIRRKMEELYGHPGNIDLWVGLISEKRLAGALVGPTISCIISDQFRRLRGGDRFWYENEGIFTKLQLQEIRKSSLAAVLCNNGDDIDRVQEDVFEYIGKRPMNFYKKCGDIQQINLNVWQSCCEKSCLPSVEQNFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8H5</accession>
    <name>A0A0N4U8H5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS213</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8H5"/>
    <dbReference type="WBParaSite" id="DME_0000334701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000334701-mRNA-1"/>
        <property type="gene ID" value="DME_0000334701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826810at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000334701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6358" checksum="03E052996BA5BEA3" modified="2015-12-09" version="1">MDPFETNVQSSPVKVLQLANDIFFVNGRKPARKLLILAHEGNSSDLVAETIETRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8X6</accession>
    <name>A0A0N4U8X6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7521</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8X6"/>
    <dbReference type="STRING" id="318479.A0A0N4U8X6"/>
    <dbReference type="WBParaSite" id="DME_0000351601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000351601-mRNA-1"/>
        <property type="gene ID" value="DME_0000351601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000351601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37161" checksum="8F0C197F112B5CD7" modified="2015-12-09" version="1">MEECTTYLFQNPKREILSVFDAYRDYLQMITELNESVKGIMTTDDVFVSNSTMAMIEMLEKFENWISEYPPADMADQRFGNKSFRNWYERLSQEAFCAIEDLLPPNKKGAVVELVPYLLDSFGNSIRIDYGSGHEACFLIFLLCLRKLGIYGVDDNKALVLRIFLKYLRIVRNLQMTYRMEPAGSRGVHALDDFQFIPFLWGSSQLIGNKLIVPDSYLNQEIVEIYASRYLFLDAIKHINEETNFHREIPLIANTFQTKTGPFHEHSNQLWNISAVQKWEKVNSGMFKMYEAEVLKKFPVIQHFVFGSLFSIEQVKVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9E2</accession>
    <name>A0A0N4U9E2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7704</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9E2"/>
    <dbReference type="WBParaSite" id="DME_0000369901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000369901-mRNA-1"/>
        <property type="gene ID" value="DME_0000369901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042794" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000369901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10018" checksum="488C91910378A83A" modified="2015-12-09" version="1">MIFLALSQLLLSFILIAFALLILSVNNNENELKSANSTHKLDNMDNGDLLQSPLDLKTYSPLNDSISDLYGECFHIQPISNIERPIVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAC9</accession>
    <name>A0A0N4UAC9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS463</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAC9"/>
    <dbReference type="WBParaSite" id="DME_0000409901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000409901-mRNA-1"/>
        <property type="gene ID" value="DME_0000409901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN50490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000409901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11749" checksum="AC8B31B82343CF16" modified="2015-12-09" version="1">MNEYSHIFHTLNRPTYKAEGEFWLIHPVLWRLLTANPTKRILNVWFLFGQNGISRCFHRWLQRKAQSVVPMQFSIFAVFQFYYFMRAFPLFSVDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAS9</accession>
    <name>A0A0N4UAS9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein MTO1 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8158</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAS9"/>
    <dbReference type="STRING" id="318479.A0A0N4UAS9"/>
    <dbReference type="WBParaSite" id="DME_0000427501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000427501-mRNA-1"/>
        <property type="gene ID" value="DME_0000427501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000427501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="652" mass="73827" checksum="8A4F82A277C43404" modified="2015-12-09" version="1">MKHSRLLTNAVKLFDVIVIGGGHAGCEAAAASARSRARTLLLTHRKETIGEMSCNPSFGGIGKGHLIREIDAMDGLCARICDKSAITYQALNTGQGPAILGLRAQIDRDLYKKYMQEEIICGTPNLTVIEGSVGDLIIENSTKPECIKVSGVILENGQMIRSNAVVVTTGTFLDGEVFWGLKRFPYGRLGEKACTKLSQKFSQLGFKIGRLRTGTPPRLLKKTIDFSKFELKPADKNPIPFSFLTKTLWIDPDKQLPTYLSYTNDRVAELVRKHYKEHKYIRSEQIGPRYCPSLESKIIKFENVYHKFFLEHEGLESELIYPQGMSMTFAEDVQREIMRSIPGLENVEIAQAGYGVEYDFINPQQLHSSLETKLVKRLFLAGQINGTTGYEEAAAQGNNFIASILAGINAAAVTRGIKPLLLDRTEAYIGVLVDDLTSLGTNEPYRMFTSRAEFRLHLRPDNADIRLTDKAYHMGVVSEDRYSHFLNLKTRLKDATELLKSIKYPLATWPKYLQNFKPKNKLGKVYTAYDLLHRHDISFRELERAFPKEMSPFLDNELESRIRIEGLYKKQHDLLVEKMITVRREGRALIPENIKYSNIDGLSFECMEKFEQWRPQNLAAASRVPGVTPEALYILLRYIKTPEIQKHCCVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB96</accession>
    <name>A0A0N4UB96_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphatidylinositol 3-kinase catalytic subunit type 3</fullName>
            <ecNumber evidence="1 7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS8346</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1 7"/>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB96"/>
    <dbReference type="STRING" id="318479.A0A0N4UB96"/>
    <dbReference type="WBParaSite" id="DME_0000446301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000446301-mRNA-1"/>
        <property type="gene ID" value="DME_0000446301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="560"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN58373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000446301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="866" mass="101019" checksum="2D5EC9E56F4C8E93" modified="2015-12-09" version="1">MDHEFLYVYSYEINENVRIRVVSLEGVASSLERFLYVTGNNFFVTVTVYCNDRSVGCPVSTSYKPPPEIIRHALHEWDEWIILPVKYSELSRDSFLRLCLWDVGKELEPRFVAQATITLFSMKGVFRCGPQSLCLERESSFDQLPSKKPYELSDTDRLHRLTKDYGETLIDHVDWLDRLTFPRIERLKRESENSQRCLFLMIELPRVVLGNNTYSIVYYERDEDTKISPYNAPYPTDPELGMDNLCEAKHHMLTRSARAEIFERELKPNASTRETLEKILQMPSSYPISVEQRDVIWKFRYYLRSNKKALTKFVRSVNWNETKEVMQALQLISEWSPLEAEDALELLSPSIQNENVRRYAVSRISEASHDEILLYLPQLVQALRYEPFTINDNFRVSTQIFSSDEENDETGNGEKYNDNAMQRVSQECEVKNDLSSFLIRSACQNQFIANYLYWFLKVEIESTRLVKPDISEMYKTVMEQLLAKLETGNDESRQWNQYFKRQQKLINELVATAKYLSQNYSSRSERTTALKRILQEKEIFENLGNIPLPLDPSIRVTSIVANEAFLFNSNLMPMKLTFSTEQNQNYVAIFKKGDDLRQDQLVVQMIRLMDGILRADGLDLRLTPYRVLATSSTEGFVQFVKAKPFRDVISTWGSITGFLQSFRPSQSGTFGIEQEAYDNYIRSCAGYSIICYILGIGDRHLHNLLLCENGKMFHIDFGYILGRDPKILPPPMKLSPEMIHVMGGPERKEWHDFRSLCFSAFNILRRHANIILNLFSLMLDAGIPDIALEKDKAVQKIEQRLVLQFLYNFCTIWRLFIVNSFFFRFHLDLNDEQANRLIQRLIDVSVSAKMPKITEMMHDINQLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBW3</accession>
    <name>A0A0N4UBW3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8604</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBW3"/>
    <dbReference type="WBParaSite" id="DME_0000472101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000472101-mRNA-1"/>
        <property type="gene ID" value="DME_0000472101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000472101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="5120" checksum="6C27A42E9D77BAFE" modified="2015-12-09" version="1">MDLLFFHISKLTLRIIFDWLSVKRNVFTRSAPIIFNSILLLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC51</accession>
    <name>A0A0N4UC51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8709</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC51"/>
    <dbReference type="STRING" id="318479.A0A0N4UC51"/>
    <dbReference type="WBParaSite" id="DME_0000482601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000482601-mRNA-1"/>
        <property type="gene ID" value="DME_0000482601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869960at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061172">
        <property type="term" value="P:regulation of establishment of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039269">
        <property type="entry name" value="ANKFN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437:SF1">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000482601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27998" checksum="882032E694BF7DB4" modified="2015-12-09" version="1">MKLSLCWHINFAQFNRTSNSHFRINFIETVYQMQNNASVHYIPLCKVLSKKYTNNYLNKIIRKIPEIINFHESINISIENGLYLCYMKLFSDVKSIHIIVPENLPSMLPFILIRDNSHITKDEWEWIRLLEKDDENNMKPTRNQLAFHKLLVNSINKLAKQYEINNIWDNRLYRLQIFYIKTNISFILVFHLCTYNMDFIKKYCEISLFIEYLLMVCLFFHYVHVYSRISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC92</accession>
    <name>A0A0N4UC92_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TFIIS N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS496</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000004">
        <property type="protein sequence ID" value="VDN50523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC92"/>
    <dbReference type="STRING" id="318479.A0A0N4UC92"/>
    <dbReference type="WBParaSite" id="DME_0000487501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000487501-mRNA-1"/>
        <property type="gene ID" value="DME_0000487501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5878044at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="3">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000487501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="656" mass="75705" checksum="50DF5FF9E1989457" modified="2015-12-09" version="1">MANGQKQQYMPMPSYFLQQEETSDDEITRNSNYLIDESIEGDDTEFDEPLIQFKNRQPQQQQQRGIPPNTFYAFSSSQPSSSGISQDNIRFAPVKPSLPQQRLLNQRSICFNQVKAAPLHDLRGDYQTRHLREAYQRQYIDNSANYNLMPSSSSFAPHRFVSSVPVSRSHQAQRVIYDDEEEPYDYEFEDEEETFDEEQPEIYQHRSQQLVHHVAAEQPKVVSNENNRYTIVGHTTEGQPIYALQSVSHSEHPRLQPVQAVRQNIPVEEKYYRIRAQPELISARRIASEYYVCSSNRSETAVSASRLNENILNEKQFVLQEFPIVPSSSRSTQQNLNSSTVIRNKRKSSDSSEKISDSAVAAQAGAIQRFSTIAGWKQMSTWLKTAENSKDWNKLKLLLIQCGQAALTLELLQSNDTPRFVRRLSKICPDIDVRRIAFDLVAKWKKIVASQPVPSEEPKRVGSLKRKTPHPSTNSSKKIIRKNILEKNEQTISMAISSGNSVTVNRASEKNRKEETERKTSNDDIEESLQKNMKEKDEKSEKEQMIATGKSEKLEKNNKVTSNKMNEFNMFEKLGEERKEKKKRPKTAKTYTSKFRSTGILVLLDESIFIHASFPYLEMIINLPLILINVRWRMNLVTVVFNSSRLFLFLYLSYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCQ1</accession>
    <name>A0A0N4UCQ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8854</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCQ1"/>
    <dbReference type="STRING" id="318479.A0A0N4UCQ1"/>
    <dbReference type="WBParaSite" id="DME_0000505501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000505501-mRNA-1"/>
        <property type="gene ID" value="DME_0000505501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000505501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21655" checksum="770BAD7E1DEAB105" modified="2015-12-09" version="1">MVGNVFASQLHVWVDMSSQSDSASGIRSLIFTCFGLIPYFSWYYSFVIFLISQEAAAIIVARLASWGAVNENDISDVLHWVDRSLFGEYHNARLISHMFISFVLCYRGELKFKFEFLIPYDIDSSNLTDLSSFNSTNETVYCLCSILFVPLDFYSILECFEKHGNDPANSLLIFTAILAWRKLNYQDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UCS0</accession>
    <name>A0A0N4UCS0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OMPdecase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8877</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UCS0"/>
    <dbReference type="STRING" id="318479.A0A0N4UCS0"/>
    <dbReference type="WBParaSite" id="DME_0000507801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000507801-mRNA-1"/>
        <property type="gene ID" value="DME_0000507801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="5">
        <location>
            <begin position="190"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000507801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53842" checksum="708FE0F88E4E2287" modified="2015-12-09" version="1">MQAHFTSVNQNGDRSLPIVGPTHHTFCASEVKIFNCTTEKRNLKIFLMRTSGGSVLNLVDVLREEGFVINDVVCIVDRQGGAETKFSAEGLNLYSLVKLSDVVEYAVDRGFLNSADYKIIMDRIHESLADNCPEKSTIWSLNDRLTLTKSSFNKRLIEIMLKNVMALTSGNSEFLFLHLCENIYYTKKTSVCLAIDYTRTDEIESLLELAGPYICAVKLHADIIENFDLNFMLRMLDMSEARNYVILEDRQLYSLGLNLIKFGDTGRTVEMQLMRGYHRIALWADIVTLHPLPGISLIETVKKVGAILKKGSRLDGCLLVTDLSTVNALTYARDSIKGNIIKHRYYFSVILKSAQSLIINLVFNHYLMFLAFTNLNFFLAIQKMAIRNPEYVSGFICQRRFMDDPAFLYWTPGVNIDVSSDGSGQQWRSVEDAVIRDMNDIIVVGRAVCESKYPIETLIKYRDAAWAALSAREMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD47</accession>
    <name>A0A0N4UD47_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Splicing factor, arginine/serine-rich 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9029</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD47"/>
    <dbReference type="STRING" id="318479.A0A0N4UD47"/>
    <dbReference type="WBParaSite" id="DME_0000523001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000523001-mRNA-1"/>
        <property type="gene ID" value="DME_0000523001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12338">
        <property type="entry name" value="RRM1_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12601">
        <property type="entry name" value="RRM2_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000053">
        <property type="entry name" value="Serine/arginine-rich splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000523001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26129" checksum="A0B9D29E9641B7B7" modified="2015-12-09" version="1">MSRECRIYVGNLPSNVRSKDVEELFSKYGKILFVDLKDRRPPYFAFVEFEDPRDAEDAVRGRDGYDYDGYRLRVEFPRGVGPRGPGGRPYDSGRGYGGGNSGYNRGRSGRRTNYRVIITGLPSSGSWQDLKDHMREAGDVCYTDVLRDGTGVVEFARYEDMKYALRKLDDTKFKSHEGETSYIRVREDDGGRGGRGSSRSRSPIARATRGSPQYSPQSRSRSKSKSRSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF39</accession>
    <name>A0A0N4UF39_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS971</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN50998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF39"/>
    <dbReference type="STRING" id="318479.A0A0N4UF39"/>
    <dbReference type="WBParaSite" id="DME_0000603201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000603201-mRNA-1"/>
        <property type="gene ID" value="DME_0000603201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874132at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF1">
        <property type="entry name" value="PROTEIN CBG06911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000603201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29712" checksum="B333731BCFE38BC9" modified="2015-12-09" version="1">MNSSTATSSSTSVSIECAVCCVGNLCTPEELCEHMQNYHGMNKAVIETITFSDKVQFQKWLESVEDSRVECSGYVAQDKRKDTDVNPQEEYYLLCRKRSPTLKRRRITSESTNYFLHTNLTICCTAFVHVIEKSDGTTSVQFCLEHCGHCAKDSMPSNYRSMIMSSNLSPLSSKRSLKRFIDSIESEDEDCNNEEEMNVDCIVHDQTNIGHEDPHAKDGTNVDLSLTSRRLEYTIDQTKNVITILCDLINHFKTDNANSIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFE7</accession>
    <name>A0A0N4UFE7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9451</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFE7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFE7"/>
    <dbReference type="WBParaSite" id="DME_0000615501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000615501-mRNA-1"/>
        <property type="gene ID" value="DME_0000615501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864177at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720728" evidence="1">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000615501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47988" checksum="FEDFF6F9FDCB378D" modified="2015-12-09" version="1">MNRIYFLINFLFFLCDIATRPLLLNNSKNSDQENTNNDAWIHFSTIAKTTAEIRGEHHDETVVQRSSLTRNLLNKENFVASINKNGTNFIHGTNILDIKSVEEKNNEKITVSSTELHYLLNSGIENLKITTTTSPPVIIKSVFSHELEIPSRHTKIPDLKNQTEIIDLDLSESDVYDDFAIPHNEIESNIQDVSSHKIILEETGQYEGKESPVQYPIESTCDTGSTEAPRSFEDEFFDERGKTIQKDEIVISVALPTAAIKSEYQVQKETLEFHFAPTAPSKSVSESKIQFAVKEKNFIENTSGTKLKPTQSVLVPQVISKIKENEILESKNLEIEKDSRKNFNDKLKPLNPAEEEIKFDNIDNLADIREELSWWQKLIAGFKCSQRDCAEALKPRKKIAKFLTEPAIIRRVRTHGDKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFP1</accession>
    <name>A0A0N4UFP1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1164</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFP1"/>
    <dbReference type="WBParaSite" id="DME_0000626701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000626701-mRNA-1"/>
        <property type="gene ID" value="DME_0000626701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF51">
        <property type="entry name" value="CUTICLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033230149" evidence="9">
        <location>
            <begin position="18"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000626701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42248" checksum="B9D52710C19285B2" modified="2015-12-09" version="1">MFIFTVVCLAFIGFTIAIPLDNGVEGEPEIECGPTSITINFNTRNSFEGHVYVKGLYDQQGCRSDEGGRQVAGITLPFDTCNVARTRSLNPRGVFVTTTVVISFHPLFITKVDRAYRVQCFYMEADKTVSTQIEVSEITTAFQTQVVPMPVCRYEILDGGPTGQPIQFALIGQQVYHKWTCDSETVDTFCAIVHSCFVDDGNGDTVQILNEEGCALDKFLLNNLEYPADLMAGQEAHIYKYADRSQLFYQCQITITIKEPNSECERPKCTEPQGFGAVKAGGGSQRIATALPRLLKKRSADYDNTMDVRTDISALDISNQNQALPFDLRHTSQFYYGHPVVLQSTKDIICVSSMGFLIVAGLGMLLTATMIIFSCSRKVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFR0</accession>
    <name>A0A0N4UFR0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000015">
        <property type="protein sequence ID" value="VDN51212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFR0"/>
    <dbReference type="WBParaSite" id="DME_0000628801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000628801-mRNA-1"/>
        <property type="gene ID" value="DME_0000628801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871823at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000628801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24214" checksum="BB0DA80C2E7D25BC" modified="2015-12-09" version="1">MQIVPENALRSSRSSFTSDDLPYVLKGKVVSQSSPFVSKNEYVATITEIRNNASPTETKNQPEALVSSKIDEMSQQYESETLPPGIPPFLKGASLDIHRRFLEIVFNRNDSFRGKQTKLDELVSKLDIKNQQMYEQFRKNKDIEETERRSRIHALVATMSDKAQAAFAKISAVLMNPDTKDFERQEMLQKIYSKVESSVKNEFNRRFAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFV4</accession>
    <name>A0A0N4UFV4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1238</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFV4"/>
    <dbReference type="STRING" id="318479.A0A0N4UFV4"/>
    <dbReference type="WBParaSite" id="DME_0000634101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000634101-mRNA-1"/>
        <property type="gene ID" value="DME_0000634101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000634101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="599" mass="70092" checksum="2E7EBD74D4BF6486" modified="2015-12-09" version="1">MSTKHLRRLLEEKEGQMQKNKKEKSSSESDKEGQIYPANRFALLEENDDKSFKSDYNSGTSEDCDTADGHFQNLKQMPKKWGKTKKKKKMPKKIFNIIKNSDDGELDLHIRSLDNLLVSAETVKFIRERDLFKVDYKALNADDELRMMLGRTSKNIVKNNRNFRIDLGQKIVRRDPSWPEFKAVGLSMEVDKVEGDRRWFKFVFSKDYIEYQKRFLLAVKNFDHHYIMNILNERPYHLDSSLMVASILYHQEEYQQSRILTERAIYGCQCAFSNFFELHNYDHIFDYSLVENRSFFLLLNQHMKNAFNRKCFQTALNLAKLIFRLCSIKDPMGILLIIDAIAIRARQFCFVIQAYETLEPSRNIERLPNFAFSVALAHFLLYQENGDEKNRESANEMLTKAIYHFPTVLLQILEHINLEPSASVLQNEFMCILAHHRETEGFQLLTSIYLKHTSDFWKDVSIISWVESVVEEILPTMNDSNEELIEWNAIRKRVYAGTPRTVIRHAWLWDIIRNSEWTLNDPVPPIDSRSSYDYLPPAEPPIDPLYSIVQEAIRNIHHIFGGIQLNVGLINSKTNTNVSIAHIYNTTQIAIVQLKIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGF3</accession>
    <name>A0A0N4UGF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COX6C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1301</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000018">
        <property type="protein sequence ID" value="VDN51328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGF3"/>
    <dbReference type="WBParaSite" id="DME_0000657201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000657201-mRNA-1"/>
        <property type="gene ID" value="DME_0000657201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5779631at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000657201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7777" checksum="AC4FC2528F8FC7E2" modified="2015-12-09" version="1">MKYQRFKIHLTTVGIIAGIVVSTYGVSRLALKIKEYSNEDSRFAEQEIQDWIYLKEIAAANQRQSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGK4</accession>
    <name>A0A0N4UGK4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PolyA_pol domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1273</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000017">
        <property type="protein sequence ID" value="VDN51300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGK4"/>
    <dbReference type="STRING" id="318479.A0A0N4UGK4"/>
    <dbReference type="WBParaSite" id="DME_0000662901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000662901-mRNA-1"/>
        <property type="gene ID" value="DME_0000662901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229952" evidence="9">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000662901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13632" checksum="CE4A4CED17928B5F" modified="2015-12-09" version="1">MSVRVLCLFLACSSGLNDTKEMKLIREIFETNNFQLRIVGGTVRDLLMDVMPTDIDLSIDAKPHETEKLLSDANIKVHDGRHGRSSNQEYTNDWRIGASRRDFTIISLYLDDFIVADQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH80</accession>
    <name>A0A0N4UH80_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1502</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH80"/>
    <dbReference type="WBParaSite" id="DME_0000688801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000688801-mRNA-1"/>
        <property type="gene ID" value="DME_0000688801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000688801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12622" checksum="6AEB4B30E3BB8B65" modified="2015-12-09" version="1">MKIGAFGFLYSYGTSYNPFGCGYYGQQQQQQLLKYPCYGTNYGSSSYADYSYGSQQNPCSQYQYSGGQQYPCIGYPFTGSAYQQPFGSVYGRSNIPYLCSGCLNYSGYMGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHA1</accession>
    <name>A0A0N4UHA1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS1526</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000023">
        <property type="protein sequence ID" value="VDN51553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHA1"/>
    <dbReference type="STRING" id="318479.A0A0N4UHA1"/>
    <dbReference type="WBParaSite" id="DME_0000691201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000691201-mRNA-1"/>
        <property type="gene ID" value="DME_0000691201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229895" description="Cullin-5" evidence="9">
        <location>
            <begin position="22"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="416"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN51553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000691201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="60312" checksum="D7BA31A85CC67F75" modified="2015-12-09" version="1">MEWMPAKRTILALLRCQVVFLGRIEEVSHNEWQELFVIIHRICTWVVEGSRLATVNLFSEINQHVSAVYRQLQCHEDDKKLLKAYSEEWSKYYLQTEILPKPFCYISSGYINLPIDTVINPACPVKRATDEVASVSVSFISYRMLHYWNKIVFERMRARLSSASMRLIESERNGTEYSPDLIIAIRHSYISLNSNDISVYQLEFEKAYIECAEKYYKSNAPEVLETNGVKNYMTYADSRLLEEEERGHRYLDPGAHSVDKLLERLVQVIVEQFEDQILGECNSLLKSNHMDMLKKMYRLINRTSSGIPKILGCLDQYIRIEAFEEMKANVDTITTDPEKYVEQLLLMFERFTDLISVAFYDDPRFLTTRDQAFQDVVSDTRIFKIELCSSKLKAIASGNDFKHPLFSGTRVQVESKCPELLANFCDLILRKTAVSKRLNSDEVDTKLNQVLLVLKYVANKDVFMRFYKAHLTRRLILEISVDQEKEEQVVTRYFLNFRVLAKISLFYIRKLQFANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHB6</accession>
    <name>A0A0N4UHB6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Solute carrier family 12 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS9762</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001190">
        <property type="protein sequence ID" value="VDN59789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHB6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHB6"/>
    <dbReference type="WBParaSite" id="DME_0000693001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000693001-mRNA-1"/>
        <property type="gene ID" value="DME_0000693001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="395"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="18">
        <location>
            <begin position="598"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="18">
        <location>
            <begin position="715"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN59789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000693001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="976" mass="108783" checksum="08FCCC2EFC5220F1" modified="2015-12-09" version="1">MLRSISLYQTVVPTAEENEIPKKPIKKAQMGTIMGVYLPCMQNIFGVLFFIRLTWIVGTAGIVQAFFVVFLCCSVTFLTSISLSAIATNGVVPGGGPYYMISRNLGPELGGAVGILFYLGTTIAASMYITGAIEILILYLLPQAKMFENIYHCFRVLGSALLVILGIIVLAGVKVVNKFALPAVFVVLTCILCTFIGAFIKFNGSDSLKFCMVGDRPVDLVSFHQKYHYVPNCTEQGLQPLFCTSSNATLICDEYFMRMSKIISWKRKDAIREEIAIPGVASGVFFENLWSKYLASGDILTKSKRRVAVLSTSGYYIFADQATSFMILIGVFFPSATGIMAGSNRSGNLKDASRSIPLGTLGFIFLPPNKMFIRDKFGQSAMSKLVIAELAVPHPTIILIGCFLSTVGAGMQSLTGAPRLLQAIASDDVIPFLSIFQQMDSRGEPILAILLTLFICECGILIAVIENITALITQFFLMCYLGVNTACALQSILKAPGWRPSFRYFHWSLSLIGSFLCVAVMFISAWHFALLAIFIGATVFKYIEYAGAKKEWGDGLRGLALSAARYALLNIDTKPQHTKNWRPQLLVIDPDNREDEDAMLSFISQLKAGKGLTLVAKCIQGDFIEKASLVEEDKNKLIHLIKKHKIKGFCDVLVTANTIEGISCLVQTSGLGGLRHNTVVIAWPDAWRSLNDTGACKLFASTLRAAAAAKCAILVPKNIRLFPKSHEKVSGHVDVWWIVHDGGLLMLLPFLLKKHRTWKNVLLRLYTVAQVGDNSVQMKRDLESFLYHLRIEAQVFVIEMRDSDISEYTYERTMKMEERCKLLKDLQLSEKKFDLQNAVTEAARERRLSKINEEEPSSHLVYFNHFMDSSKKSDGICVRFSDSTQEENEEIMIDLEQQRYDKIQSFNVRKMHTAVKLNELMREKSSDAQLIILNLPGPPHENDGQYYMDFIDELTEGLQRVLLVRGTGAEVVTIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHL1</accession>
    <name>A0A0N4UHL1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS1598</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000025">
        <property type="protein sequence ID" value="VDN51625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHL1"/>
    <dbReference type="STRING" id="318479.A0A0N4UHL1"/>
    <dbReference type="WBParaSite" id="DME_0000704601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000704601-mRNA-1"/>
        <property type="gene ID" value="DME_0000704601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="47"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN51625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000704601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16829" checksum="CE0C8EE8590181AD" modified="2015-12-09" version="1">MVRTKQTAKKSLAPPAKRLNAKRLLAKRQKANKANKSATLKQKRFRPGVVALREIRRLQRTVNLLIPRAPFQRLVREIARNVAQDNVDLRFQMAAILALQEAAEIYLTCLFEDTNLAAIHAKRVTIFPKDMQFVRRLRGENVKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHY2</accession>
    <name>A0A0N4UHY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1657</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000027">
        <property type="protein sequence ID" value="VDN51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHY2"/>
    <dbReference type="WBParaSite" id="DME_0000718601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000718601-mRNA-1"/>
        <property type="gene ID" value="DME_0000718601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="519"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000718601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="651" mass="74286" checksum="5F0D090C53278F66" modified="2015-12-09" version="1">MWTYTAITAIIQAIGWHYSYAMLGEIFEDSTCRSTNNTCGINMIFVPILKVVSSKNLLTSEKCIQRCSCITDEYAERNGSCIERIYSSKEQCENEICKIGETILDVDCNLSGNVCGINALFVLISQEIPYPSMVPRNCIQRCTCKSIEYIDKLTHCKKKEDFKIEGQTDSYGFTEYCPKAYYNLGDEIADIGCRLAGHECGINMRFVLMETLKAANSQNQSHIIGCILRCNCEENFEFFEKDGQCARKWYCEGGFCHLKRKIYDYGCRLTGLECGIHMKFVTTKKINDGICIQKCKYAKDGKYKDKKKNKQNFVEHKSITKFLKTGQILEDFGCLSSNTECGKNMVFRPVVRFYNISSSLSHEKCLQRCTCNDKFYEENGRCIKRIDIDEVDYEDDYEDKDFVINQRCFENKACQLGEKIIDIGCQLTGIKCGINMVLSPTSIAINNQCVQYCVCDIEFMVEGNKCAKRNTFKTTSSTEYQNITQERTEENTGNIVIKCMRGECELSEEISDLGCMLDGHSCGRNMVFKKISKKIYRTALKNMNCIVICECEDGYCEKNNQCVLPEEPSNPCERKICKAGERIFDADCHLSGVKCGVGMKFITVQKLHPSSSCIQECHCESGKFEDSEWSLCRKDVISVNFVEVIFRIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI01</accession>
    <name>A0A0N4UI01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1682</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI01"/>
    <dbReference type="STRING" id="318479.A0A0N4UI01"/>
    <dbReference type="WBParaSite" id="DME_0000721101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000721101-mRNA-1"/>
        <property type="gene ID" value="DME_0000721101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000721101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20006" checksum="069AB889C6106BC0" modified="2015-12-09" version="1">MDGYSGILCESICDRSCKNAGQCVIENGISRCICPKGLGYVGEECEDEIIDCTTQGCDPGERCVQNAKGSPICIIDPCSTNPCVNKAICSPTYLKSNSETAEASFTCNCTVGFSGKLCENDIDECESNPCLNAGICKNAVGSFSCICLNGFSGIFKLLRFLSVVDLLSLVVYSSYLHSTLLFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI08</accession>
    <name>A0A0N4UI08_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS1689</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000028">
        <property type="protein sequence ID" value="VDN51716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI08"/>
    <dbReference type="WBParaSite" id="DME_0000721801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000721801-mRNA-1"/>
        <property type="gene ID" value="DME_0000721801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837678at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF112">
        <property type="entry name" value="TRANSTHYRETIN-RELATED FAMILY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042852" evidence="5">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN51716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000721801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15665" checksum="2ADD70FABBC74087" modified="2015-12-09" version="1">MFWTWLYFFISFTAAFRQQSFGIRGKLICGHSSAEGITVKLYNDKAIGFNNQLAETRTDGDGNYELTAATDSIFSMEPYLKIYTNCNRGFNPCKREIKLEIPSDYVTRTSTIQQWFDGGIINLQFKFDDEERKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UI38</accession>
    <name>A0A0N4UI38_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9920</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001196">
        <property type="protein sequence ID" value="VDN59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UI38"/>
    <dbReference type="STRING" id="318479.A0A0N4UI38"/>
    <dbReference type="WBParaSite" id="DME_0000725201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000725201-mRNA-1"/>
        <property type="gene ID" value="DME_0000725201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000725201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13346" checksum="8E7A223D5FBF69E1" modified="2015-12-09" version="1">MKLVRFLMKLAHETVTIELKNGTTVEGTINGVDVAMNMHLRAVKVRHRNGEAVSLDTLSVRGNNIRQIRLPDSIALDTLLVDDEPRKKAARGGRGRAVGRGGPRGRSRGRGGPRGRGAFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIE5</accession>
    <name>A0A0N4UIE5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1735</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000030">
        <property type="protein sequence ID" value="VDN51762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UIE5"/>
    <dbReference type="WBParaSite" id="DME_0000737301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000737301-mRNA-1"/>
        <property type="gene ID" value="DME_0000737301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF71">
        <property type="entry name" value="FI05338P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000737301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28978" checksum="3AFE1C25D57DA047" modified="2015-12-09" version="1">MRSFYPTWIAPNLLTLSGFLCALFAFFVVSFFDYEFSSNSQFSSSTHTLDGTDGKQARRTGSSGPVGELFDHGLDSWSVLPFTVTLFSAFGRGEFGLTTQSFLCILIGSQFTFILSHWEKYNTGVLYLPWGYDFSQFNNVYEIVLPLFSSFTLFIISYFWAEYSPNNISDIDPRVFYCVMSTVFSNIACRLIVSQMSSTRAEAFNGLLGIYCSVFLMCIPGYFSAVYELLLLRVLCIVLIIAHLHYGICLVCFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIP0</accession>
    <name>A0A0N4UIP0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Asp_protease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS1769</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIP0"/>
    <dbReference type="STRING" id="318479.A0A0N4UIP0"/>
    <dbReference type="WBParaSite" id="DME_0000747601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000747601-mRNA-1"/>
        <property type="gene ID" value="DME_0000747601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartic peptidase DDI1-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN51796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000747601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22132" checksum="DCA525268D101F0E" modified="2015-12-09" version="1">MNDPTDTEGQRLIEEQIRLKNIIMARNYAIEHMPEAYIPVNMLYISIKINGVLTQAFIDTGAQLSILSDSEALRCGLLDVMDKAYNVTVHGVAGKMECIGKIHACVVQIGDNCYHCNFEVLSGQATPVLIGLDFLRRHLCVIDLKNDCLRFYFLLHVLNPLLIAFCKYISFFSFGDSSKTKFLSDAEINISHHHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIT6</accession>
    <name>A0A0N4UIT6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GB1/RHD3-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS1801</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIT6"/>
    <dbReference type="STRING" id="318479.A0A0N4UIT6"/>
    <dbReference type="WBParaSite" id="DME_0000753401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000753401-mRNA-1"/>
        <property type="gene ID" value="DME_0000753401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="64"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN51828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000753401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64709" checksum="FAC215796C370FED" modified="2015-12-09" version="1">MDNNDAKFGADSELRDASEEENMITPNKKYMDALRIIETVEEDHSFRLDIEALERILLVPEITDKKVSIISVAGAFRKGKSFLLNFFLRYLQADLVAQQNGDWIYGDSYLNGFSWRGGSERETSGIMLWAKPFVVKNRNGEEVVVLLMDTQGAFDSQSTVKDCATIFALSTMLSSMQIYNLSHNVQEDDLQHLQLFTEYGRLALESTTVKPFQSLLFLVRDWSFPYEAEYGFQGGERLLDRRLQISSKQHVELQQLRRHIYACFESISCFLMPHPGLRVSTSPLFRGEISDIEMEFQQQLRCLVPRLLDSSNLLMKKINGNEVTCRELVEYFKAYVTIFQGEDLPEPKSMLMATAEANNLAAVSTSKAHYVKQMEEVCGGDAPYLSSNDLADHHEHFHHEAIKLFKNARKMGGTEFSFQFLEKLEADIEEQYGSFVKMNNSKNLFKSMRTPAVLVAFMIFDYVLQEFFQLIGLDSIAGLFSTALCIAIFALCTWAYSRYSGNFRDAGIMVDKAVAWAWVNFLSSVTQEGMHKAVAIGHRLAQVFSSNYERNMPKRNLGMKIKIFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ54</accession>
    <name>A0A0N4UJ54_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">DME_LOCUS10104</name>
    </gene>
    <organism evidence="37 39">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="39" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36 38" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ54"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ54"/>
    <dbReference type="WBParaSite" id="DME_0000767001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000767001-mRNA-1"/>
        <property type="gene ID" value="DME_0000767001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
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    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="VDN60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="WBParaSite" id="DME_0000767001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="559" mass="64365" checksum="DDF3DCD6047A76FA" modified="2015-12-09" version="1">MRVCVIGGGVSGLPAIKECLTQGFEVVAYERTSDIGGLWNYRPEMNEGGTVMKSTVVNTSKEMMAYSDFPPPAHYPNFAHHSLIMEYLREYAKKFDLCQYIKFNTNVDEVILRFLKLSGMTSAVEFFDFAILCTGHHSFPSYPTIEGNEKFKGRTLHAHQYRDSSGFEDKNVVIVGMGNSSLDIAAELARVAKSARAWIFNRVFQAGMPYDAKLMTRFYYKLMDILPWTIVNDFMEYRLQQRIDHDLYGLRPNHRFFQQHPTLSDELPNLLCSGRIVITEDVDCFNETSVAVKGGKHFSADIVIYATGYTFKFPFLKPQSAIPIKEHEADLYKYVFPLDYPTLAVVGLVQPIGSIAPISEMQARWIAAVFRGQVKLPSKVEMHADIEQKRAELRRRYYKSPKHTIQVDYIKYMDEIADLVGCKPQLKKYFLTDPKFFLQLFVGANAPYVYRLDGPGAWDEAKLTITELPNRIKLPLKNRECKVRRHKRRGKIDEYFRYGSMKWLSGWTCLILTTGLWTFCSGPAGLSILSYSLYVLTFLILFSFMLLWFDFQYDMATIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJD5</accession>
    <name>A0A0N4UJD5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1962</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000039">
        <property type="protein sequence ID" value="VDN51989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJD5"/>
    <dbReference type="WBParaSite" id="DME_0000776501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000776501-mRNA-1"/>
        <property type="gene ID" value="DME_0000776501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000776501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8124" checksum="DDB87F9ADA3B44D7" modified="2015-12-09" version="1">MLQNHLDDFILHVRKGDSNQLDVIEEEEEESETTTTLTFGDNSKLTVQRVDDLKRLSTLTNDTLSSSVVEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJX4</accession>
    <name>A0A0N4UJX4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HOOK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2113</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
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            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000046">
        <property type="protein sequence ID" value="VDN52140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UJX4"/>
    <dbReference type="WBParaSite" id="DME_0000798801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000798801-mRNA-1"/>
        <property type="gene ID" value="DME_0000798801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000798801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31420" checksum="BDC0D658E43266F5" modified="2015-12-09" version="1">MNKMEEEMLASERLISIYKEASEDAEKQLKEITLDFEERGRLLAQMKIGKVIILKVESISYFSLHFCLVSLTDDEIAAMSPTAAAASLLIKSGVSLTGIYKEHCRVIAELEEAKLENKRIEGYLRELVDDIEHKAPLLAQQRFEFDKMTNICSNLTTQLETADEDKQRLLSSRDAIARELAYTRAELERCQRDNEDLNRQVRHLLHTIEIDKVSGRDADSPPISAEDRDILWSSIGQLQQANQKLMSDLRETKINQDKMVQEANSAEWVFKIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK02</accession>
    <name>A0A0N4UK02_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS2144</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000047">
        <property type="protein sequence ID" value="VDN52171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK02"/>
    <dbReference type="STRING" id="318479.A0A0N4UK02"/>
    <dbReference type="WBParaSite" id="DME_0000801901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000801901-mRNA-1"/>
        <property type="gene ID" value="DME_0000801901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN52171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000801901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12690" checksum="039CE74DC9C26106" modified="2015-12-09" version="1">MTDVWKSNARKFCELCKVWFADNSVSIQHHEAGQKHKAAIQAKLREVGKQSNILSFKGDIIGPSLKPKSYLDPRAHKASVVSMAKEISKQKSEVRLMKATFLFFCLSFLSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKF3</accession>
    <name>A0A0N4UKF3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2268</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000052">
        <property type="protein sequence ID" value="VDN52295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKF3"/>
    <dbReference type="WBParaSite" id="DME_0000819201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000819201-mRNA-1"/>
        <property type="gene ID" value="DME_0000819201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851321at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000819201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46668" checksum="24F6DDC1ADE3971F" modified="2015-12-09" version="1">MKVEKLKRIRSRGKSKELKEDEQGDELRVADLKRSLILKKSIVVQNVSEENTGHAQQVISLAPSNKNFILIYTGRVAIISDDQVTAGNTIDSSSTTVDLEPTNWTRNLIKNQQKSMLNGFSWNLQRKMLNVAIHQELFIQSTSLVSFLSIRIPFMDLSIKSENLPLDKFDREANAFKIELIREKNWEKRANEQRALLVLQKFLVCFISPNLTVQFKLLSRQLELRDGKFIKLIELANRCKDITIDHGNNNNNNNNNNNNNNNNNNNNKIALNTLGVNTLGKVYVLSKSNEDLFVLTQNLKLLYVMHFLNPSHETCNFIITFKNCQTAITRLNSVRLLSFLLTSPFLPIPGIIQIFNNRFIPTWGRVEILDMITLAVVTQLFLSYYVILFLIMRKVAHKMDYANRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKH9</accession>
    <name>A0A0N4UKH9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AA_permease_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2297</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000053">
        <property type="protein sequence ID" value="VDN52324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKH9"/>
    <dbReference type="STRING" id="318479.A0A0N4UKH9"/>
    <dbReference type="WBParaSite" id="DME_0000822101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000822101-mRNA-1"/>
        <property type="gene ID" value="DME_0000822101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829096at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000058">
        <property type="entry name" value="Amino Acid Transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF523">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000822101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="58990" checksum="A60856F3D3CB9C46" modified="2016-06-08" version="2">MEKKDNKMGVFGAVSYVIGNIVGSGIFIAPKAILEETNTVGLALVVWVVSAIISVIGSFCYVELGTSIKTSGADFAYLCYVKWYPIAFAFMTIGCLLTYPATLAIQSLTFSEYIIKGIGVRIADPIFEDFAKKLIGFSLLWLLMFLNFFSLKTFVSRFQILATIAKIAATAIVILTGFYFLIFKGETENIAEPFAHTQFDIGAFVTALFAGLYSYDGWDILNFGAEEIKKPKKTMPLAIIIGMSIVAIIFLSINLAYFVVLDVDQIKESSAVASAFAKAKLGNFYYAVPFLICILLIGSLNSTIFAASRYLYAASRQGHLPSFISCSNTKTDSPRVAIFLCIFLSMAVSFVGDLDTLISYVGFAQWSQRACTMIALLWIRFRHKPVDTNAIRVPIIMPTIFLLICMSLVIVTIVSRFHISRIGLIVITAGFITYFIFIYERSLPSLKSFRQFSFAFDNATTIFCQIIFNGMPQKTEENRLNDEKLNKEQLFSIFNEKPNHIEHTRMRKSFVYCKEDPPIYISTNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKT2</accession>
    <name>A0A0N4UKT2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2368</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000057">
        <property type="protein sequence ID" value="VDN52395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKT2"/>
    <dbReference type="STRING" id="318479.A0A0N4UKT2"/>
    <dbReference type="WBParaSite" id="DME_0000836201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000836201-mRNA-1"/>
        <property type="gene ID" value="DME_0000836201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000424">
        <property type="entry name" value="ANTP homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF81">
        <property type="entry name" value="HOMEOTIC PROTEIN DISTAL-LESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000836201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22857" checksum="3EE5BA97E04266A9" modified="2015-12-09" version="1">MVFIVLEHSTKIIEGGEVRINGKGKRIRKPRTIYTSHQLQELQRRFNKTQYLALPERAELAAQLGLSQTQVKIWFQNRRSKHKKMSKNGYAGERTGSEDDRGEEEEGSSTEAHSSPATAMVAQERTIPTTDASWNIHMHQSSQQAMLPPPPPPPLASALSQPMAMPQFDIETVDVKPYYDAMSGYYQQQNPYITPYNYGSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKX1</accession>
    <name>A0A0N4UKX1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS2415</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000059">
        <property type="protein sequence ID" value="VDN52442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKX1"/>
    <dbReference type="STRING" id="318479.A0A0N4UKX1"/>
    <dbReference type="ESTHER" id="drame-a0a0n4ukx1">
        <property type="family name" value="Neuroligin"/>
    </dbReference>
    <dbReference type="WBParaSite" id="DME_0000840901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000840901-mRNA-1"/>
        <property type="gene ID" value="DME_0000840901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="6"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN52442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000840901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="595" mass="67718" checksum="F18F5C9FD714D89F" modified="2015-12-09" version="1">MPRKITTHGLIEGYYLKHNGQIFEVYEAVPYAQPPVADLRFKSPLPLTPWDDIKNCGKGQRKHCVDFRFNLNKNQGLEDCLYMDIILPAEQDQSTNSSALPILIWIQGISYQIHSKDEYSFASIAENFAAYSIIFISINYRLGPLGFLSGGHRDLPGNFGLDDQIEALRWIKNNAKNFHGDPDNIVLAGESCGASSASLLSVSPKTFGLFSAAVLRSGSGLAPWAVRSTSTENNSARFIDYLGCTYNHTLGMSHIIDCLQQLNITKLFEGWLYIAQTSSKVESHLLGHTYFTPTIDLYRIDESIIPCEPTVLIQKNARIPIMIGVTNTESAFLLKNNPEGNRLSSNDEWNLNQVISPNLYANYRHIQKAIEFHYMSNNQYFDETDHLLTKIVTDENFKAPAAREAMFYASKNLTVYAYSFQYVSDSLNSHSTKAHHQVAHGDDSMYLFHATKFLQWSESDRNVAKRLSHQIVNFLHVRSTGEPQALPYTLLHKVATSITGPSSDEQIDFYTDVSYFWYETIPTIEMLNLEPQYRVLLQPCTMCEYPYKIPFYIILILLIFVTICSLMPFIRRQRIRHNSKYTLNNGMPPPSDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKX3</accession>
    <name>A0A0N4UKX3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mastermind-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10356</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001213">
        <property type="protein sequence ID" value="VDN60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKX3"/>
    <dbReference type="STRING" id="318479.A0A0N4UKX3"/>
    <dbReference type="WBParaSite" id="DME_0000841201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000841201-mRNA-1"/>
        <property type="gene ID" value="DME_0000841201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10578304at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000841201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="20035" checksum="E8C94FCCAB64C30B" modified="2015-12-09" version="1">MADVMDPPAKKPKLSSPSEYEDETLAQLEKMEPLPSSQSQASGTGSSIDSSQQPSSVHMPLSNGPSSMNAGSVSASSTAVGFSGPGSQSQSSGPSQAHCASNQQNQPSVLQELLLNPSNPSVQAVNSPRPAYSTPFQTRSPLTSAASMISPANCPQSMTVSGGPTGPRGLRAAGPQMFNPAGHPDMGQLQSVKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM54</accession>
    <name>A0A0N4UM54_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2755</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000078">
        <property type="protein sequence ID" value="VDN52782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM54"/>
    <dbReference type="STRING" id="318479.A0A0N4UM54"/>
    <dbReference type="WBParaSite" id="DME_0000890901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000890901-mRNA-1"/>
        <property type="gene ID" value="DME_0000890901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000890901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17376" checksum="F57DCF218D8A17D0" modified="2015-12-09" version="1">MILSDITNNYGCSVYANKTAERGENVYLYLMRYFNPSTYNFIRSSMPFKAATHGIELIYSLGANIFVAPFCKKKEDIKVSNYVTKLWTNFVKSGDPNVDTDAANENLGFIWEPVSPYREGPYLTIDTVPYLRSNFMDGRMRKLHTIFSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMH4</accession>
    <name>A0A0N4UMH4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10571</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001226">
        <property type="protein sequence ID" value="VDN60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMH4"/>
    <dbReference type="WBParaSite" id="DME_0000905001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000905001-mRNA-1"/>
        <property type="gene ID" value="DME_0000905001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000905001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17423" checksum="7622F2BCF47F11B8" modified="2015-12-09" version="1">MKILSIVFYLRCQLSIIVFAAIILDTEPSRSIFPTSPIKVVSFLAKQRSVNEMSPVENALAGSLASVFAAFVLCPTELIKCKLQAQREVNPDVHRSFSSLHHLLLFLLSFKLFIFIMYSYYIFFFLLYDIYIYINMGDKLITFYARHIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UMZ3</accession>
    <name>A0A0N4UMZ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2990</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000094">
        <property type="protein sequence ID" value="VDN53017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UMZ3"/>
    <dbReference type="WBParaSite" id="DME_0000925301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000925301-mRNA-1"/>
        <property type="gene ID" value="DME_0000925301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN53017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000925301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8847" checksum="6887D305A23C76FA" modified="2015-12-09" version="1">MASKVSKAMTEKLPEKALRPIIIQPPPPPPLVIIRPPPPVSLCRDNHVDCPKYVNQCFVGDYGKVMRIQCRKTCRYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNH5</accession>
    <name>A0A0N4UNH5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein YibB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10671</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001234">
        <property type="protein sequence ID" value="VDN60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNH5"/>
    <dbReference type="STRING" id="318479.A0A0N4UNH5"/>
    <dbReference type="WBParaSite" id="DME_0000945701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000945701-mRNA-1"/>
        <property type="gene ID" value="DME_0000945701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411632at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000945701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="38214" checksum="0178A6FA924A356A" modified="2015-12-09" version="1">SNTIIQFSAIQFCFTKTLLFYYINTFRSSKIQIKKINRMGSNHICLTYFSIAEVSTSKFTLVTALLDIGRGNWWEYRRTIENYYQYLDNILHLNVDLVIFLDDKSADYIYKRRRGLGFEQKTKIIPISFYELPFYAYIHKAEEIIKREQQGIFWDSNWDETMKHHPEGKSAIYNILVNSKPYFLYKISIENPFSARFMVWLDAGYGHGNRSIFPKNYEWKPKFLPNKISLIQVTPPHDKISRYTMADLYRKNWAVLSGGFIAGDIYALNRFYAYYYRVFAEMINQNRIDDDQTTMVLLVQQHPQLFNIVHGDWFDAFKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNL0</accession>
    <name>A0A0N4UNL0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3179</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000111">
        <property type="protein sequence ID" value="VDN53206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNL0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNL0"/>
    <dbReference type="WBParaSite" id="DME_0000949301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000949301-mRNA-1"/>
        <property type="gene ID" value="DME_0000949301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF44">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000949301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17734" checksum="B7A7591E29C2B5A0" modified="2015-12-09" version="1">MADLAAKFAEHEITPNIIPNPPAKLLNCNWDGIQVQPGQTMSPRNLRFAPRVTLDVDPESTFSLIMIDPDNLSRKNPSVAEWLHWLVTNIPASNILEGINGGQHQMAYGSPAPQPRTDLHRYIILLFEHQGRRIQVPKPSSRAKFNIKQFMQKHNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNY0</accession>
    <name>A0A0N4UNY0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3293</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000120">
        <property type="protein sequence ID" value="VDN53320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNY0"/>
    <dbReference type="STRING" id="318479.A0A0N4UNY0"/>
    <dbReference type="WBParaSite" id="DME_0000964301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000964301-mRNA-1"/>
        <property type="gene ID" value="DME_0000964301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF85">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000964301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32541" checksum="112C074047939702" modified="2015-12-09" version="1">MSDKAHFALTEWKPVNDRMAYARFKGKFCNISVISVYAPTLSADDRDKDKFYAELQLLTKSLPKDDIIIIGGDWNARVGHNAAAMTSTIGKYGIGDRCANGERLRYAEEHELFVTNICFRHHKKHLVTWNSPDNQHFNQIDYILVNRRWKSSVLDSRSYRGTGNLHGSDHVMVRAKIRIKLTIRRKQHPPSSFNYLKLKNSGTVSAFQSELLKHLNDTNINDFSGTANEYWCKLKECLRKSATSRLGHTITFTYRFFSGSTEVSPIAFPKYWSNYKDAYNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UP12</accession>
    <name>A0A0N4UP12_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Sodium/calcium exchanger 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS10730</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001240">
        <property type="protein sequence ID" value="VDN60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UP12"/>
    <dbReference type="STRING" id="318479.A0A0N4UP12"/>
    <dbReference type="WBParaSite" id="DME_0000967801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000967801-mRNA-1"/>
        <property type="gene ID" value="DME_0000967801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF75">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041040000" evidence="21">
        <location>
            <begin position="18"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="337"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="465"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDN60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000967801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="780" mass="87897" checksum="91963B7EE06F3434" modified="2016-06-08" version="2">MLINFLFLTILVCPSVAKTNKTCEEKKICQPGLFLPLWYPQENLPITTIAMRAIVYFFALCYMFLGVSIVAERFMASIEVITSQNKEVKLRRITGEPYTILIRVWNETVSNLSLMALGSSAPEILLSVIEIIGNNFQAGDLGPSTIIGSAAFNLFVIVAICIYSIPNAEKRRIKNNSVFLVTVLWSTFAYIWLYLIISVFSPGVIQVWEGVLTFLYFPLTVLSAYIADKYTGAFGKRFVNITRFRQIRRPVELNMKSRTGDGLRRGKQRDLLTSSHLPEEVVAFEQQRQKYLQLFRQMRNENPDLQPVQLEKLILERVIAEKPKSRAFYRVQVTFTTNIRQIYRKTRLFLICSFKPNNYVCMENVGTISVNVVCDRGGFDQPIVVTANYKTIAGTAKEHEDFVPVSGVLRLDPDQTEQQIHIQIVDNEIYEDDEYFSVFLSGIRAYRADDPTSKIPARLGGVALATVLIVDDDHAGVFGFSSEKFKISENSGVFTAQILRTRGARGEVSIPYKTTDGLAKAGRDYVAVDEVLKFQDGQTKAEIEIQIVNDDEYEKNEDFYLELGEPIWHREGLTCFETEKGKPVLSRHHRCKVVITEDREFKSFIDKMIANASNSFMIGTDSWKQQFSDALQVEIDNGRVLSVLSIPWRFVFAVIPPTDYANGWLCFAIAIIMIGFLTAIIGDLASHFGCIVNLKDSVTAISLVAMGTSIPDMFASRTAAIHDKWADSSIVNVTGSNAVNVFLGIGFGISFDYLMAKMEFHTLAFSLKIPIGHDINKMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPR4</accession>
    <name>A0A0N4UPR4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10814</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001251">
        <property type="protein sequence ID" value="VDN60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPR4"/>
    <dbReference type="WBParaSite" id="DME_0000996401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000996401-mRNA-1"/>
        <property type="gene ID" value="DME_0000996401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813795at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041042888" evidence="2">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000996401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21586" checksum="2CAAA93D3C2A64CF" modified="2015-12-09" version="1">MILSLILLILNLNESYGGTIVIKECHNGGVDKDQPGPGETPRRPVPSATACHDNDQSGLCNILFPNADIANSVDPTKPYKVNENCSSATHSSIATKFCASTCALCCKIPRFSACHDTASNCTLFENPALCTSQHLYAFALERCAKTCGLCDKPGSAGTTTVVASSCRDERVDCARHLQFCRVSPFSSYYSVYCRKTCSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ84</accession>
    <name>A0A0N4UQ84_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000166">
        <property type="protein sequence ID" value="VDN53702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ84"/>
    <dbReference type="WBParaSite" id="DME_0001015901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001015901-mRNA-1"/>
        <property type="gene ID" value="DME_0001015901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265509at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001015901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8540" checksum="817510178912DC75" modified="2015-12-09" version="1">METAVRLGDNRKLFRLLHKATITQGMVSKMIQGNNGVPVKPIKDRLIKWTKFFEAIPSPSLFRPIFHRPPQDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ86</accession>
    <name>A0A0N4UQ86_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3677</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000166">
        <property type="protein sequence ID" value="VDN53704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ86"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ86"/>
    <dbReference type="WBParaSite" id="DME_0001016101-mRNA-1">
        <property type="protein sequence ID" value="DME_0001016101-mRNA-1"/>
        <property type="gene ID" value="DME_0001016101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001016101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7061" checksum="B7FA5C46EE6FC8B1" modified="2015-12-09" version="1">MKFDDLLVKYLGDFGRYQLIQFSLLCLPIIFTAIHSLSWTFVASPLPHRYFNLILQIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQM5</accession>
    <name>A0A0N4UQM5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase III subunit RPC1</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DNA-directed RNA polymerase III subunit rpc1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DME_LOCUS3814</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000192">
        <property type="protein sequence ID" value="VDN53841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQM5"/>
    <dbReference type="STRING" id="318479.A0A0N4UQM5"/>
    <dbReference type="WBParaSite" id="DME_0001031901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001031901-mRNA-1"/>
        <property type="gene ID" value="DME_0001031901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDN53841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="DME_0001031901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120601" checksum="6B301489463A5A70" modified="2015-12-09" version="1">MNSEISGLPMELQPKKNMQGFAQRLKGKQGRFRGHLSGKRVDFSGRTVISPDPNLHIDQVGIPIYIAKTLTFPEIVNKANIELLRKLIINGDDVHPGANHVVDRITGNKRFLRYTNRKLTAAQLKVGDIVERHISDNDIVLFNRQPSLHKISIMAHRVKVMPGRTFRFNECVCTPYNADFDGDEMNIHVPQTYEARAEASLLMGVKSNLITPRSGEPLIAATQDFITGGYLLTHKDSFFPRSEVHRFAAAIIDSKAKEQTRIRIPPPTILKPIELWTGKQLIELIIKPDIKSTVNLNLTTKNKNYVGNEELCNNDSYVIIRNSVLLFGVLDKALLGSGSKVNIFYLVSRDFSEDAAIGAMWRLARMATVFLSNRGFSIGIGDVRPSPELLEKQTELLAKGYGKCDELIKSLEEGRLKVQPGFTENETLEALILKELSAIRDHAGQACLRTLSSHNAPLIMAVCGSKGSLLNISQMIACVGQQSISGHRPPDGFEGRSLPHFERREKTPNAKGFVKNSFYSGLTPTEFFFHTMGGREGLVDTAVKTAETGYMQRRLVKCIEDLCVNYDGTVRSSTGEIIEFDFGEDGLDPASMEAKDGNVVDFKHVLEHIRNTVPFSWKDEGGLQIEEIRTLVASTIRNKLGSGKYQRFREQLENFIFGHLDKTSKYYSIPSYCNKHKSNRAKCYDCISQNRYRQKLIVSNCLSHSQAVAFVEFCDKKLKRAIAEPGSAVGAVAATSIGEPSTQMTLKTFHFAGVASMNITQGVPRIKEIIDGVKDISTPVITAALVDETNENLARLVKARIETTTLGEICEYLEDVYLPDDCFILLKINAPLVRALRLEITMDSIVNSICSAKLPVTVKASQVKVRSKTILTIRPPDMEKCSKLMALQFLKYGIGKVIVKGIRGVSRCVIHADDKKGESYKLLVEGNSFLEVLATIGVDGRRTTFNNALTVAKVLGIEAARTSIIQEILSTMQNHGITLDRRHVTLLADYMTFRGEVLGITRNGLVKMKESVLLLASFEKTMDHLFEAAFFSQEDKISGVSESIILGTPINVGTGLFKILHKSSPVNTSRQKTIFEMYDFKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQN2</accession>
    <name>A0A0N4UQN2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF5110 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3813</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000191">
        <property type="protein sequence ID" value="VDN53840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQN2"/>
    <dbReference type="STRING" id="318479.A0A0N4UQN2"/>
    <dbReference type="WBParaSite" id="DME_0001032601-mRNA-1">
        <property type="protein sequence ID" value="DME_0001032601-mRNA-1"/>
        <property type="gene ID" value="DME_0001032601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF145">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="8"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="4">
        <location>
            <begin position="323"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001032601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="553" mass="64705" checksum="D65530B4E6FAED67" modified="2015-12-09" version="1">MEKHYEIFALAYHQCRWNYNDEEDVSTLQTNFDKYDIPVDAIWLDIEHTDGKRYFTWDLKKFPNPHEMIFNVSKKGRKMVTIIDPHIKKDENYHVYKEAKELGFFVKDHNGKSDYEGHCWPGGSMYLDFLNPMVREFWASKFAFDQYVGSSENLFTWNDMNEPSVFSGPEVTMHKDAKHHGGWEHRDVHNIYSFYHHSSTYNGLKKRSNGKVRPFVLTRSFFIGSQRTTAVWTGDNTATWDQLRITIPMLLSLSISGIPLVGSDVGGFFNNPDEQLLVRWYQAAAFQPFFRSHAHIDTKRREPWLFSNETRNIIREAIRLQYGKPVMRPLFVEFPNDETSFDEEREFLIGSGLLVRPVMEPDVSSVSLYLPGVRNVVWYDWTTHKAYPAPGAIYVNTPLDIIPLFQRGGTIIPIRRRIRRSSALMRQDPITLYIASNYKDDFATGSLYLDDGESFEHLNGEFLYFSFIYKKEGDQLYSISSQNLNGRGKMKNDVYIEKIVIRGVRYFPTRVHIFLDDWNPESLDFDHDRDLQTLVIHRTNAPVSAEFRIDIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQR0</accession>
    <name>A0A0N4UQR0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS3833</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000197">
        <property type="protein sequence ID" value="VDN53860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQR0"/>
    <dbReference type="STRING" id="318479.A0A0N4UQR0"/>
    <dbReference type="WBParaSite" id="DME_0001036301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001036301-mRNA-1"/>
        <property type="gene ID" value="DME_0001036301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN53860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0001036301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7851" checksum="21049AF95255C9FB" modified="2015-12-09" version="1">MIRCPYGSKCIPQRGECECKSMCTSPGPTVCGTDNVSYASECHLAIRSCILVQQGSKQIRVKNIGTCGKFGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQY1</accession>
    <name>A0A0N4UQY1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000212">
        <property type="protein sequence ID" value="VDN53927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQY1"/>
    <dbReference type="WBParaSite" id="DME_0001044401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001044401-mRNA-1"/>
        <property type="gene ID" value="DME_0001044401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803266at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="324"/>
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    </feature>
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            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="EMBL" id="VDN53927.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001044401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43971" checksum="4B2C765466125791" modified="2015-12-09" version="1">MDDDFRLYAVSWRKGGAYYFVSETLYHKSGKTFEERRTLMAKKIKGSQKSDSAKFADLFVHIGDAEIKGNLPVEGIFNTQLYRESLNDANDQQLEQENHLLKIIKIEKARALADATETEQELARIKSRIKSLTNIYNSQKHLYDDLQRNDEKKRIETKNLNNQISDREKSCKQIKKALENDKKLTEKLELNLAKLKQQISEMQQKIQQSKLSELEEEAKINTLIHERKKRNKEQKIMKEKFEKTLNSLMRNAKSKEESDILVTTLKKERQKQEIMLEEREKELEKRKIYLDNIKSKLSKAENELKIMKEKCLQSEKEWNQLQNESKLGSFSDVDNFSEILKNGKKLIRISNMQNHSDDEVLQKRLNANVRIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UR54</accession>
    <name>A0A0N4UR54_DRAME</name>
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        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000232">
        <property type="protein sequence ID" value="VDN53987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0N4UR54"/>
    <dbReference type="WBParaSite" id="DME_0001052501-mRNA-1">
        <property type="protein sequence ID" value="DME_0001052501-mRNA-1"/>
        <property type="gene ID" value="DME_0001052501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001052501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="14029" checksum="A407BF1DAF7711B1" modified="2015-12-09" version="1">MTRGMIRKIVRDNNGVPIKNIKYRLIRWQKFFEAKISHVAQSIDLDIADTFAEPYIYNWEVPTEEEIIISVVHKFKANKSPEEDPGEDGLRAEFFINVVHRPLQRTFNKYKKSSFYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URI1</accession>
    <name>A0A0N4URI1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4077</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000275">
        <property type="protein sequence ID" value="VDN54104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0N4URI1"/>
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        <property type="gene ID" value="DME_0001066301"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001066301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8047" checksum="F5C4E2E436BB26EA" modified="2015-12-09" version="1">MSQELFALIINSKRTTGKKLETLFKEINGMDLTSLDQMLTREHQLHEVRRTSTTRGSKNINYMRFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2J6</accession>
    <name>A0A158Q2J6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Titin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4628</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A158Q2J6"/>
    <dbReference type="WBParaSite" id="DME_0000026801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000026801-mRNA-1"/>
        <property type="gene ID" value="DME_0000026801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612025at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001843">
        <property type="entry name" value="KETtiN (Drosophila actin-binding) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sallimus, isoform P"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000697">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000962">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
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        </location>
    </feature>
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            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
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            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
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            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
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            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1264"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1395"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1527"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1661"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1797"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1933"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2034"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2187"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2322"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2759"/>
            <end position="2830"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2841"/>
            <end position="2929"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="2948"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="3069"/>
            <end position="3157"/>
        </location>
    </feature>
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        <location>
            <begin position="3043"/>
            <end position="3069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="3043"/>
            <end position="3062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDN54655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000026801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3161" mass="354554" checksum="3E20E47007EB01A8" modified="2016-06-08" version="1">MGNDKSTSDFDGIRMEFGNGNGTGSSVCSFTVCDWTVALKKKVGIDGFELEHIFISNNITYIHMPGVKINKAINFMRDSFKRLFSSFKVEWLHNGHPLGASSRHRLMNDFGFVSLDIHYIIEEDAGTYTLVVSNPAGKAETSTKFEVERLKSILFDTSHPESLRRIQEIESIQPAKPSEDEFIPTHPVFTQDLVGPTEVLKEGQSVHMDCMVQPINDPNLKIEWFLNGYPILFGSRIRTIHDFGYVGLEFLHVHPEDSGLYICKASNAAGEATTEFFMECKPRRNIYLETQHANSWVKIQEMENHEDIREPSPDMVFSPPTFIVPLQNIDGVVEGDRIRLECRLQPANDPTLKVYWTKNGQPLPEGSRFMPARNFDYVNLDLLAVYGEDSGVYSCRAISEFGEATTSCTIKCQPTDALLLHTQHEESWNRIQDIENRRPQEPIYEEPLKIAPNFVVPLPQQIGSFTEGSPIHVEAKIEPTNDNQLTVEWFHDGRPLVNAHRFRMTHDFGYVALDILYAFPEDSGQWECVVRNDLGEARSSAIFTVTGGNVILSDSQHPESWQRIQIIEAPREKAADIVELQHGPPKFTEMLQPAERIEGQPVHFETRVIPINDPKMQIQWFKDGAPLGNSNRFSHTSEFGYVALDIAYTIEEDSGTYAVFAINDEGKDQVETTLNVQPQSVSNTLMCTFSVILGDVQNERSWQKIQAIEQPKLKPEALPDVVYGPPHFVKQLNSNLDLIEGQPVHFEAAFEPIKDSNIVLTWYHNGRPLTASSRITMRNDFGLVSLDIHYVLPEDAGEFRCIISNSSGRDETVGKLQCQTRASILGDVLHAESWRRIRELEAPKTVPAAIEAPTYAKPTFTQPLQSVADVPEGSTIVLEARVIPVNDPKLQIIWFHNDAPLQQSSWHVISNDFGCVSLRISPVFSHHSGVYSCKAVNEQGTAVTSASLSVLGDDSLQLGSQHPLSLQKIQQLEALNKFPQLEVVDQEFGKPNWVKIFENIDDLQEGEIVLLNGFVEPVGDPSLRIEWYFNNAPMQNSNRYRHENDFGHVTLTIVHVLPQDSGVYTCRAINASGEAVTSATVKVAGRFSHSFIRCYEAIVRSTQHPLSWEQIQILEAPAILEEVEDIDEKEKPRFLTHLESYSDVPEGDVIHLEATFQPARDPDLKVIWLLNGQPLGASQLIKTKSELGWATLDINGVNVDHSGVYTLKIINSEGEAASSASIKVLALGNILTDTSHEESWKKIQIIEAPKEKSPEPPAPVYEAPSIQTQIIDVECSEGEPSHFESIVAPTNDPNLQVLWFRNGQPLAHGSKYAISQDFGYCTLDIGYTYPEDQGIYQIRVINDAGEAVSSATLKCHQQDAILGDTQHEESWRRIQELETPKPEAPTVPPLPKTVPRFLTEIQNIGDLYEGQPAHFEATVEPVDDPDLKISWYLNGAPVEASSRIKVINDFGWVIFDINQTEPRDTGEWTCVAKNSAGEARCSAILNILGRDSIVCDPIQLQSLQRIQEIEAIKPLPGEPPSKIYNAPQITKHLQNPSDLAEGDSAHLEAQYTPIDDPKLKIEWFRNGQPLFHANRYKMVQDFGFAILDILHLFAQDAGQYLLKVSNNAGEATSEATLEIASKEGLILYPQNEDKARAVQQLEDTLHKKPEELILDEKKVVPVFIEPLSAPLSCEEGDRVHFTARYEPIDDNQLQILWFLNGKNLKTGSRVKTINDFGIVVLEIFPTYPEDSGEYTCRALNQVGEAVTSTQLTCIPREVIITNSQLPERMSGAYNKIQEIETPKGPKPDMPDLDHGSPHFLNQLENLPTLVEGQMAHLEVRVEPVADPNLKIEWFHNNKPVGHTSRMKTIHDFGYVVLELSPVEPQDSGTWKCRASNAKGLDEVSCEIQVQGTSGISYDWQSLSVRKERIIQLEDWIHRPKDDLDQPQQEYGAPYFTQNLEDLGQIGEANATAFTCVLEPIGDPSLQIEWQHNGHAVPYSNRIHMTNDFGVATLLIKHLISEDSGEYKCIAKNAKGVAETIGRVEVTSAIEIESPKIIQPLVQSIDGVVRIFLSFYSWFYSEGEPFHLECRFTPINDSKLTVHWMKDGVPLQEASRFKFSCEFGFVTFDILYAYTTDTGIYECIAVNEKGEASTQATITVHPVPSLEFSPQAPGSNIENLESHMRQHTTASLALTKADAYVEALKRPPEFKTPLINIGIEEGEYCRFETQVAPVNDPYMKVEWFKDKKPVLIGHRFRSTLDFGFACLDVLYALPDDTGEYMCVATNRYGQASVSAKLACSATKHIITHSQLPQGVLVSDVKKLGDQPYWSDQTVEQHRVKQSPQFTIQPRNVQAVENEPARFECAVLGYPKPKVTWYINGNQALHGHRYKLNYDGIYYLTMLKTRISDAGEVVVIAKNSEGEVLASAMLDVFQQKDFRYVKLKPTAFKTIDELQEREIAWQKETLGQLGEAFENAPKPDQQKLVKVERSKSPIEPLESKELMEKFTRPKGDQFYNQINYVETSRPTFKGLELEPVTLKPGRIEKYELPKEEIEKVQLRSAPAVEKPTIPSGAALPQPSWAVETKLGDVEKRFNRLNEPEKEVNTPARDQVKLKIAKPKPAGAVPSAEHVEIEKERAKLASVVQGPEIPKEIDIPAKDQVTVRQKFKPKVVKPSETSTIESGPLKETPPVVKSKIEETTITSKVRLFCWTFTISFSHSNLLCYTYEERPSHNVELYNELKCDEHMQRGIQYRIYGGIERICGFRMIRPMPTKIGQTQKNPPQISTQLKPTQGEVGRSARFFCAFDGSHPMNINTTNTGSTLNINKLKPEFSGEYLCRIENVAGAVESTASLTVMKPADRGLMPEFKQRINDVRSQQNASSQFSCVVAGTPEPTTSWFKDGKPLPNDDRYNIVKEGNKHLLIITDTLPQDGGIYECVAQNPSGEARCKARLNIILAKTGKGSEEGPKLQAPRFSLQIQPVAAQEGTTVEFKAKFIGSPEPTIRWYRNNEPIKKSSNFEISQSKDETTLRIKQCAQEHVAEYKCEATNPAGKASTVANLVLQPKSSSNFHKSDSVQMEPQTNGNKKSSSKEPPQFISRLTDISARPGHTVKFIAEISGNPQPTIAWQFNGRPLYGSRDNKIYMTGNKAVLEIQRTSHANAGLYIVTIRNPLGASQCQAKLTVENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q2Y3</accession>
    <name>A0A158Q2Y3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GST N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5476</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q2Y3"/>
    <dbReference type="STRING" id="318479.A0A158Q2Y3"/>
    <dbReference type="WBParaSite" id="DME_0000111601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000111601-mRNA-1"/>
        <property type="gene ID" value="DME_0000111601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03080">
        <property type="entry name" value="GST_N_Metaxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF32">
        <property type="entry name" value="GST_C_6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000111601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24729" checksum="5BDA5C96290D813C" modified="2016-06-08" version="1">RTLKKTSCNSFLKFFFKIKSINTEIYKKNWKPNIVYLYQFYRREEVLPSLSPFCLKVETWLRANQIQYESINCLFTRSNKGLLPFIELNGEHIADSQLIIQHLQKYFKIEARKRLYQHGIGRHSRDDIISILHNDIRAVDLILGDKKFLFGDKPTTADFTVFAHLATTYFLPYRQPITDLLDEKFPRTKALIVRMRAHYFPEWKYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q399</accession>
    <name>A0A158Q399_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6317</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q399"/>
    <dbReference type="STRING" id="318479.A0A158Q399"/>
    <dbReference type="WBParaSite" id="DME_0000195701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000195701-mRNA-1"/>
        <property type="gene ID" value="DME_0000195701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="51"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="251"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000195701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49812" checksum="FBB18640F7DA293B" modified="2016-06-08" version="1">MEFEKIVEISERTLDVQSSRKLSELLLAQSSIDALNRAGFIYASPIQWEALPIGMMGFDMLVQAKSGTGKTLVFALLALEGINAQLAATQVMIVAPTREIVVQIQDLLKRLAPPVFRIRSFFGGENIVEDLKALAKGVHIAVGTTGRLCHLVNIKKLKTDRIRLFILDEADKLMEEAFVKDVNFLFSSLPIDKQVAVFSATYPHNLDFMLAKYMRISDAQLIRMNVSDAQLIGIKQYVIININDNTNGVSSLIKLLNSFVYNQCLIFANSIEKCERIFNELKGKELKVMLMSSALSQEERLKVLKKLKNSTIKILITTDLSARGIDSAGVNLVFNMGCCVNSETYLHRIGRAGRFGGYGTSFTILTTENDVRRFNYQVAEAKLKVKLLEIEGERPADICENKSFYDSCCDFKVNFYAIFFMPFFEIRFLFIPFIEQIIFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3G9</accession>
    <name>A0A158Q3G9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rac GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS6728</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3G9"/>
    <dbReference type="STRING" id="318479.A0A158Q3G9"/>
    <dbReference type="WBParaSite" id="DME_0000236801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000236801-mRNA-1"/>
        <property type="gene ID" value="DME_0000236801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="318"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="386"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN56755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000236801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="653" mass="74175" checksum="81757BD9B4AF2F61" modified="2016-06-08" version="1">MNNLSSNRSVEIMKEFFNNRDHVATIIRERDNCFIDTLKLLDLLDRIRQNWKDENQKNESLRDQLLAAEQESGNLKKENRLYKEQLRDARAQIAALMSEKQSMELDISEMERKFQFVSQLLKDDMTDEEKEKLAFLKNPKCSQKKKIESRRATGASAEFIDYDKSGDSVETCEELEMSHLRNGKIYRRSHLNGANNDETKVPRPTKRSKSKIYVSNVPEEVSTPCKRSRNSRELNKENVTTVDPHAKRHSRPKVTARHSINRSLSESNVLNANEIKEAEQKFNALTPRSIAKSQIDIRSPYAQGKSWINVGGTINSRPHSFISYNTVLPEKCDVCNRHIALSALTAKPACKCTDCGVRLHVACKEHAPMPCIPRTPTSRTPSKQRPRLKDFCPPTRPMIPSIIIHCVVALERDRLNCEGIYRIPGQESQVTKLLNDLKNSRVSPKLENHYTETITGCIKKFLKELRDPVIPTSSWEEFVRAADTNDIEALNNFIMDLPIPNRDTLAYLCSHFQKICENSSRNKMTAKVLARSVAPTIVGHAPPRSMNFAQGNEEAKKQVNVMLALLQMPPGYWTNFYESNEPSRPFHSNHQANTPISSSRPVFERTPGRTPLAPIISLPGDTSILGPLGTPPASSSKLLHHVSRRGNMFENLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3H8</accession>
    <name>A0A158Q3H8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6791</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3H8"/>
    <dbReference type="STRING" id="318479.A0A158Q3H8"/>
    <dbReference type="WBParaSite" id="DME_0000243101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000243101-mRNA-1"/>
        <property type="gene ID" value="DME_0000243101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF472">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000243101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27930" checksum="801C86CFADC15635" modified="2016-06-08" version="1">MKSDTELLLCVLYEKCDWDLYEFLKGIPRDMGDSQCRKIAKQILEGLHFLHIHLIIHRDLKPQNILINRDQNVKITDFGLARHFSAQSSFTPVVVTLWYRSPELLLQCPYNTAVDVWAAGCIIAELYSRDPLFPGKTEVQQLNLIFQKLGTPSAEEWPRTAIVSRNHFSSFPAQSFSRITPRVPNEGRDLLIYFHVNLCTIFQAMLKFNPNQRPTCAKALKFQYFNKSDVVNNDNAENNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3W8</accession>
    <name>A0A158Q3W8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GF_recep_IV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3W8"/>
    <dbReference type="STRING" id="318479.A0A158Q3W8"/>
    <dbReference type="WBParaSite" id="DME_0000335401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000335401-mRNA-1"/>
        <property type="gene ID" value="DME_0000335401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000335401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24483" checksum="4162CF9F5F994E99" modified="2016-06-08" version="1">MSNSNEVPMGVNNFGDLHSVGNCHEECLGCIEPRSAVSCFTCKHLTQSLRNRAGFKCVARCDEGFFVENDKCRACSPNCKTCSKAEQCTTCPGAMFLIDVDHYGHLDHGQCVKKCPAELEPDYTSAVQARCVLKKNRCSEGYYETVTYQCKECDEACRTCHGPGPLQCDSCSANYSNLSVGYCRPCCGHDEAPMDHHCAMASDRSAWKHLTLVTSEASLTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4Z1</accession>
    <name>A0A158Q4Z1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS998</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000011">
        <property type="protein sequence ID" value="VDN51025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4Z1"/>
    <dbReference type="STRING" id="318479.A0A158Q4Z1"/>
    <dbReference type="WBParaSite" id="DME_0000605901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000605901-mRNA-1"/>
        <property type="gene ID" value="DME_0000605901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000058">
        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="171"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000605901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="934" mass="104078" checksum="6487D4A798EDC6D5" modified="2016-06-08" version="1">MAGARGALRGATLYALSWRCLPTAEKIFYENSSSNIDVGELNIRIELGGSAKANENNSDVTISNCNKVENNSYNATKQLIMQRYKAKAVHLDSPNAAKRFDMPSGNNNSPSTSSAPSAAVEQPNTSEQSFYNINTPKSTRKWKKTKALKQSSVKTEFTHGRSSDKSVPSTSALGQKIADCRTSGDGDLVPLFIQLCVKVVEAYGMETVGIYRIPGNTAAVNALKETLNHGIDNIDFSDSRWKDVNVVSSLLKMFLRKLPEPLLTDKLYPIFIDANRISSHPQRLRKLRNLVRKLPSAHFATLKYLMGHLQLVVQHSAVNKMETRNLALMFGPSIVRPSDDNMATMVTHMSDQCKIIESFITYYDWIFSEIDTGDDEVPEMVPSVCDISSYGHSGNLTAGFESDSSQGTVMTNSFNDMHNLIRKANEAEAFAMMDAQRSGKIKYILNVRRNSKRDKSRKRDHSAHATHVSTISNFSSTTSTPGSTTSNVEHTFSGEFQERNIDAEIASRIQLYTASSIATSNALSVDEPSLDSCLDSVANNAEVQTDSTREKLSDAEEIRRKRQQEISSARRIFIAGTDADPITAESNLHHADLDDLVSHTRHLNLATSPTLDVLSAETREKIRRLQQLQGWATTAVERREAGVSKPKHIPMRSANDEVNKLLMGKNVDDFSSTDALSLTSDYSTTSSAPLTMPMTVSCADHLAASSDYASSDVSPYARNASSSPYQPENDLDSAKVLFLIFCCFAYLQIVFEVVTGKTDSHIKLKKGADVVDIDYDMSDFALYPSHFISFKPRKRSKSQPKIYFRMGALNEEKLSNLSDISLNADYSGKLLMNTRNHDEHWRRHTFSDIDSIKQFIMNEKNRKNKILQHGSQKERISNVNKFAKWIKHNFHLSSSNIEQEQLSRYEHVESNERLSSGEVTPPSEILPSSGDEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5P2</accession>
    <name>A0A158Q5P2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DME_LOCUS2028</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000042">
        <property type="protein sequence ID" value="VDN52055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="318479.A0A158Q5P2"/>
    <dbReference type="WBParaSite" id="DME_0000790301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000790301-mRNA-1"/>
        <property type="gene ID" value="DME_0000790301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855789at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF136">
        <property type="entry name" value="PROTOCADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
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    <sequence length="4449" mass="500106" checksum="E53CBB3B3E8C8B7B" modified="2016-06-08" version="1">[encoded data, 4449 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Q6</accession>
    <name>A0A158Q5Q6_DRAME</name>
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        <submittedName>
            <fullName evidence="10">UDENN domain-containing protein</fullName>
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        <citation type="submission" date="2016-04" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Pathogen Informatics"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="1077" mass="122593" checksum="506DDB11921B467A" modified="2016-06-08" version="1">MEFSSSSDKNVQNSNESTLIDYFVVAGYDHNLGLQVDTTNDGGVEDLSRPPLHRSFIASIIAYYPQRRAAFLFPQEIVSLCMPKGLQFFLRNNVPSPSVHTFANIREDGSRLDGSALIYYEEVRDVALREKMSQLHMEHVRALTEKGTERVHFPPGTISGGTHTLPRGNKKDRAKRISYYDAGGNSQLYMSKCICLVNRIPIVSAAEHILMAIHSIFTSNVQPPPLPLESYIYWILNEVPLPARGSTLKVCLNEVDIVIQRPGPLELPFFDHYLSSLFDLLTVDKFLRLFTCFLLEHQILLCSKSFSRLMLVAESLCALAFPFRWQLTYVPILPYSQLKFMEAPVPFIMGVCYEDIISDQLFQCNMCVLDIDTGDLNMPEDVPLLPDRSEFAREVANVLVRFEERIFEDDVIKKRTTKTCLVKKKDDWTNKRMSRSFDEEFSSVLSQIDSATVPLSRNNLSPLPLDDVLKQSEVFARVAAIARRAGVSVQMDSIEKELLSSDNYSNSPICKKYFKEMKINNAIREVFLNRFAWLLYSYEHFVISGGYSNCEAYYSNRDSVANFDKAAFLSDQPDSNLAFLAAFLETQMFTSFIDLKIISQWETPDENLQMFDARIQALRENHGLQMVRTPTYEKALPFIISEALDYIVPLPHVLPGASVQLYDGTFPELNASLLEGLEMQSPLPSPWKQRHRRLRPKNLDKVNNLILDSPAVNRSSTYITDTPLQIAQQNLKFVEQLLKETKGKTKRMLVGKMGKEALQLGHGDAVVNGLEENTLVASFCDLLERIWAHGLIKKQGKSSLWAHILHHQELEKSGALTRNAVARHSTFTSGLLADEWSNKKENINMRQNEQNMLSELVRSMQKEMEDSSGPAWSLSILRAANFIYDKINAVSTIEYPVKTVDTCSSATNSFLSRSSSLRRDTKPAMKKSNSVSDFAPYWVGSGSGEVIGEGTPRKRNSSRTQSPDIRKNFPPLPMHIAYDLRNVLRMAEIKTDIGYARAFVRLSLERKLLHSHLKTILSNTALLQQIYKKYAFLRSDDEKEQFLYHILSLNAAEFRCFTNTFCKTSWFSLLFPQLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6N5</accession>
    <name>A0A158Q6N5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTCK domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DME_LOCUS10939</name>
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    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001283">
        <property type="protein sequence ID" value="VDN60966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6N5"/>
    <dbReference type="WBParaSite" id="DME_0001062401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001062401-mRNA-1"/>
        <property type="gene ID" value="DME_0001062401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781148at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054450">
        <property type="entry name" value="TIL-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22897">
        <property type="entry name" value="TIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="TIL-like" evidence="1">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001062401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38860" checksum="7AC66BF2E67FF212" modified="2016-06-08" version="1">MTMCVLHCICANAEFIQMNEEHIKNPQDSVQSQYSECKKENCTIGETIVDYGCKRAEMKCATNMKFKVISELKSNGAHRLTKCFLRCECDSNNFIEKSGKCIKKVPNEEAKCKQENYALGEIVVASSCIQTETKCGTNMVFKLIGKLDSLSDAIWLRKCIMRCSCDNNYFIEKSGQCVRVIHERVPISSIQPSSKHKSTAYSPLSCQNGNCLGQIIWDACHRIGNKCGTNMVFDLVYENHSGDSCLMRCVCNSESVENNGRCVENSLINEKTIQKFIAPRLPRINEKFYNSDCRQTQLACGRNMKIISIWKNPTDQENRFACIQFCACNDGFVEFKGRCIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PEI1</accession>
    <name>A0A3P7PEI1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000599">
        <property type="protein sequence ID" value="VDN54314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PEI1"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018132943" description="ShKT domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="174" mass="19300" checksum="38FF770D765DC961" modified="2019-02-13" version="1">MQAYILAWILATTLSSPIQNCKDERQGCAAIRASNSCGGVFRTTMMQQCARTCGYCTIVALSEKEIGEFSTCKVEQQYILSLTVQNARIARIIINYIHNDGMEKGNVTFTNGAAVAIDVCNVPKPRMGQMPVQRPSVPVENCQDRDPLACFELFKPEDLNNPQLGMVLMNNQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PET8</accession>
    <name>A0A3P7PET8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000063">
        <property type="protein sequence ID" value="VDN52510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PET8"/>
    <dbReference type="STRING" id="318479.A0A3P7PET8"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="236" mass="27578" checksum="D2F64E8021EA8B83" modified="2019-02-13" version="1">MPFEIRPVLAHDIMNEEIPLTEFFVLNVIEKKKLGEILKYLPQMPTWANHLKRIKSGNVLIQPLSFPIDEILRLKLINVFGEIFTFERVLVPSRKPITRQQFTWAKQRWPVEFHPNKNVEAMLNGTFFDKKQQKEIINFFLEAEKVGNGGPGCLMVDLEGKVVAKSNTLQYLGTGFDVYLTEEPCSMCAMALVHFRVSRVFFCRRIPKGALESSWRIQEEKRINHHYQVFRIDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QGM2</accession>
    <name>A0A3P7QGM2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QGM2"/>
    <dbReference type="STRING" id="318479.A0A3P7QGM2"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14571" checksum="054E70790794AEE2" modified="2019-02-13" version="1">MILSAVLSQDLFFEIVRRKTHIFCDAAESANVLELKRIIEGILKIPVSKQELLKRSEDDAWQTLDDLQLLSHYGFTQQNTKAQSPAVIALCVRDGLSIVAEDDGVIIDELSSPPPIPDAMRQEQNPQNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7QVJ3</accession>
    <name>A0A3P7QVJ3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001218">
        <property type="protein sequence ID" value="VDN60491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7QVJ3"/>
    <dbReference type="STRING" id="318479.A0A3P7QVJ3"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="175" mass="19835" checksum="CB66438526701A90" modified="2019-02-13" version="1">MGSLSIDKTYDGNFTGKFHSRIQAVVLRSELEEAKRNGFYYRVRVGDESQHVQGFSEPAIILAANMDHQFRLLFNTDRQTIQSLAVFPGNVINHEENILQTKDIVKGSITVNTIRELPLPDTMSYIQKMEKERQARQHGAQNDNRSFIQKYWMYIAAAVVLMVISNAAAAEQAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SNY2</accession>
    <name>A0A3P7SNY2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS5755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SNY2"/>
    <dbReference type="STRING" id="318479.A0A3P7SNY2"/>
    <dbReference type="OrthoDB" id="9990676at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="495"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="754" mass="83301" checksum="76F713088C291110" modified="2019-02-13" version="1">MSFILKDWKSSRTILQPTYNHQHLLISGNECAPGFIYMYHIASNLLIRTFSGHTARVTSISISRNGQFFISTSLDGTTDAIDVLKPHRGKVTCSLVSTNFQYIFTGGTDSCVHKKITGSGDFVVIVWDLSTGDQAVRLGGLMAPVSCVTITSNDAFVIVACEDETLRVFGTVSGQELHELLGHEGKILAVAAAQDDCQIFAGTTSRIYVYDLHSGKLLDTLNCINQQFIFSLKITNDNNFLVSACGNKVDIWNIFHSSCDMKHANKFEKQGYCVELLINKIFNDSPDFIDVQLTTLFSLKDIVTTVAMSKDEKSAACGTKFGFVAVWDLDICQCIWTVEMSKCQAQHSQRYILMIQRKGIAVNCVRFTMNCMYLISGDNEGQICIWEASNGFFLKSLDVKLLNFLHQKNDSITQSSSLKAICFFMDDERVLSVDNSSIIFIWNISTDESPDSDPNISFNGIRAPIILSPYDDRIIGMRIWTIIDENIVPKTKIYHNEEITCFNTTTNFSLLVTGSVDQSLKIWQIDTGFLIQVLVGHENGVICCAIAEDERVVISGSKDSQIIVWNVSTGDIFLSIRTMAPVTAIYLTVDASVAISADETGWIETYDMESGQLLSSFNVHRSIKSLESSADGNRILVLPVECSQLPILCLHNTPAGTVPIRQERRPSTRAHSITSVGSNISEPKASTVLMSSHQNSNLTATTSNGFKGGPRTFDKIERARPKLSVEKERPTNSLLLSKTHSVTIAAKSALCALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SS29</accession>
    <name>A0A3P7SS29_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SS29"/>
    <dbReference type="STRING" id="318479.A0A3P7SS29"/>
    <dbReference type="OrthoDB" id="5863096at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004296">
        <property type="entry name" value="DUF236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03057">
        <property type="entry name" value="DUF236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="189" mass="21073" checksum="0A0FEACDA48FD7CA" modified="2019-02-13" version="1">MNFLMANSFLSAVRAESLPLRVYDPNYQTLAGIDADIFGEDKKRDFGGFAAKGGPIQPYRGAAGIAGYLANNGLYSSTSFILSKLKPFPDTYDPNYQTLAGLPDVFGADKKQTDGFIAGRGAFDDKGPTVPMQRGAQADMYDPNYQVSVFKNCFEFPTYMLFCKNFGYLHWIIFVGIREDIFGTDKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7T3U5</accession>
    <name>A0A3P7T3U5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001252">
        <property type="protein sequence ID" value="VDN60852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7T3U5"/>
    <dbReference type="STRING" id="318479.A0A3P7T3U5"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="94" mass="10948" checksum="CB12FD1F6E996C41" modified="2019-02-13" version="1">MEISRNFLKFRYELSVNIRENELIVEGKHEERNDENGTIQRHFIRKYEIPSDVQMDTIESNLSDHGVLSINARKVPSDSVPSEGSNQNKNNEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0G3</accession>
    <name>A0A0N4U0G3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4403</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0G3"/>
    <dbReference type="STRING" id="318479.A0A0N4U0G3"/>
    <dbReference type="WBParaSite" id="DME_0000004301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000004301-mRNA-1"/>
        <property type="gene ID" value="DME_0000004301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271433at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000004301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29013" checksum="94F7BCA5D7247438" modified="2015-12-09" version="1">MGRQLLRHFLRDSTNIAVQLTRTPLLPNSIDELVKQASSLVSSVSQTLLQIDLPDNTALESMEAPVFYADVYESNQIHTCLFGFKRAGNQIPLHNHPNMYGFIKVIRGSVQIRSYSWLNVEEKTNVLMDNSFFSHLMAHPVKITQVFFLLLFVKYLTVSRFEGVVTRTSDDDCVCLTPQKGNIHCITGLEDGATFFDLLVPGYGFSPCTYYKNYMTFDEINENSDLSSKICFLLEIPPPKSYFCHVIPYNTITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U110</accession>
    <name>A0A0N4U110_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FMRFamide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4621</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U110"/>
    <dbReference type="STRING" id="318479.A0A0N4U110"/>
    <dbReference type="WBParaSite" id="DME_0000026101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000026101-mRNA-1"/>
        <property type="gene ID" value="DME_0000026101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813613at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF14">
        <property type="entry name" value="FMRFAMIDE-LIKE NEUROPEPTIDES 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041119703" evidence="7">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000026101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16860" checksum="FBF8A91E85B34F99" modified="2015-12-09" version="1">MLLAPLTLVFVGTVCGLQILSKEALAERNDQLEPLIAKRKSAYMRFGRSGSSNEPELNSMEKRKSAYMRFGKREDDSNDFDEFQDLKKRKSAYMRFGKRYAESHETNKRKSAYMRFGKRENIVDMTEDYAPESDIMKRKSAYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1C7</accession>
    <name>A0A0N4U1C7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS4761</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1C7"/>
    <dbReference type="STRING" id="318479.A0A0N4U1C7"/>
    <dbReference type="WBParaSite" id="DME_0000040101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000040101-mRNA-1"/>
        <property type="gene ID" value="DME_0000040101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN54788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000040101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41089" checksum="B0D180156046BBD4" modified="2015-12-09" version="1">MATTNNPDVIDELEYEDEEEEETDEDVRPQVGSRAEKSLGLLTQRFLTLLQSSLGGIVDLNEAAEDLNVRQKRRIYDITNVLEGVGLIEKKSKNVIQWKGGELRKPGTKQLRPEEEEHLMLLKAELSELVEEERLIDSYIKWMKQSIRNVCDNQANQKLAYIRRDDILPVFRDSIVFVVFAPPGTSVEVGHPSRVGVLDHFFYFLLFFCFFCSEYRYQMRLRSPNGPISVMLVNKGEEDSRTSFKRIHEKFPLKSVPYPIVGDVPGQLLEGEDDDSPVKRKKLDDDVKSYDVVHLQTPCKDIVRQTDPIETKNWLSLKQSQLNCFRELSPPPNERDYIFNLNPFESVADIYADDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1E6</accession>
    <name>A0A0N4U1E6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EB1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS4783</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1E6"/>
    <dbReference type="STRING" id="318479.A0A0N4U1E6"/>
    <dbReference type="WBParaSite" id="DME_0000042301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000042301-mRNA-1"/>
        <property type="gene ID" value="DME_0000042301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000001">
        <property type="entry name" value="microtubule-associated protein RP/EB family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000072">
        <property type="entry name" value="microtubule-associated protein RP/EB family member 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="8">
        <location>
            <begin position="227"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN54810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000042301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35193" checksum="8DE914155B515FBE" modified="2015-12-09" version="1">MSVVNVYATSATTENLSRHEMLMWVNDCLQSNFSRLEEMHTGAAYCQTNQIVSYDFQFTDFLFPGSIQLRRVKWNSRLELDWLSNWKLLQTAWKSLGIDKIVPVEKLIKGKFQDNFEFLQWFKKFFDANFDGHEYNPLETRGGEPLPSIVKTNAPSRMPAAKALGHEKKSPTHSTSNVAGNKSEVRKAAPAPSKIMASVPVRNPQVNAGRTVNAAMDQQKKAIFLQLITSLKNELKDVRQQLAESDGVILSLEKERDFYFSKLRQIEIICQDNEQIGNVDVSRVFAVLYETEEGFAPPNESDAENNGEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1G2</accession>
    <name>A0A0N4U1G2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS4804</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1G2"/>
    <dbReference type="STRING" id="318479.A0A0N4U1G2"/>
    <dbReference type="WBParaSite" id="DME_0000044401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000044401-mRNA-1"/>
        <property type="gene ID" value="DME_0000044401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837936at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN54831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000044401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15132" checksum="B024D3A707EEE670" modified="2015-12-09" version="1">MYPTNWQPSSSSSSIDESVQQYWNNHHQNKILNSSTAAVTYDPLLYPQNYMKNMFGAAAAAVGQWVDSSNTFANYNSLQSSAAPTTTTTSHISVLPNDRSLQINQPVFPWMKMTGKTNFVLRFPNDSFMNESHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1V3</accession>
    <name>A0A0N4U1V3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4975</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1V3"/>
    <dbReference type="STRING" id="318479.A0A0N4U1V3"/>
    <dbReference type="WBParaSite" id="DME_0000061501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000061501-mRNA-1"/>
        <property type="gene ID" value="DME_0000061501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000061501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42563" checksum="58256680BDBC95BB" modified="2015-12-09" version="1">MALIRAHEQLGQAGERLGASALLLHVGDRLISCACSGHVRAIICRNGNAFNVNRNPLNLTADEYRQIRAGNATVTEENTIEGICHSPRSLGFSFLYPAIVPNPEKVAVEIEKEDEFLIIASRALWQFLLPQQAINLIRNVRNPQIAAKKLQRFLSKDAVQSFEYNGNISIIVIRFKKTDEKIYQNHRLLQISPLKLKSISVLSLNDEEITLRNIEERLEQISEAINKIEDESNNNQQIFENHVEGGKFNKFSKFSVRHTKHRSADSARQRENASSWNSCVNSNCDLSLTPRELSTVPSRAPSVLSAPPDPHSLELNTDSNRERFCIRSRIDMFDRLGNDTGSSTSRERFQRARLALNERLFFKPSILNPLEKCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U309</accession>
    <name>A0A0N4U309_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5453</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U309"/>
    <dbReference type="STRING" id="318479.A0A0N4U309"/>
    <dbReference type="WBParaSite" id="DME_0000109301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000109301-mRNA-1"/>
        <property type="gene ID" value="DME_0000109301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="286"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000109301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53308" checksum="04D827B2E17E1747" modified="2016-06-08" version="2">MKLKKFTSIKTEEGSEDEEKSVLVNSSQKYFNNLKMKHWRLIIRNLPFQTVVEDLEKICRKFGQCAEIVLPKCKDKRFPQSCAGFAFVQFARKKDAENIKGRKIIVDWAVPKDTYETFILRKKNWRGISLKSSLEFFLLIVSICRNLSFDVTDEQLRKSLEKYGEINLAIVCRYEESSHSKGSGFVHFKTKEQADFCIEENGIMIGDRKAFCYRALSKSDAEKIEKERKEKKPNDKRNLHLLRVSLVRPGTRAACGMSEADAQKRAKLANLSRQKLRNLHMFVSPTRLVVHNLPKSLDDKKLKSICFLAAGNPDAVISECRIWRDKNKLDSNGVPQSCGFGFVAFSEHSDALAALKSLNNNPETFTKEKRPIVEFSIENLAALRLRALRQNKSQKKYDKLSDKTKMDLEQTKKQIALGGRKPFPSHFGPKIRSRHLNVKQRKKNNTSVCLFFLFLHFLKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U314</accession>
    <name>A0A0N4U314_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-ATPase delta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS5459</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U314"/>
    <dbReference type="STRING" id="318479.A0A0N4U314"/>
    <dbReference type="WBParaSite" id="DME_0000109901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000109901-mRNA-1"/>
        <property type="gene ID" value="DME_0000109901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN55486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0000109901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17834" checksum="1548242D749AA78E" modified="2015-12-09" version="1">MSLRIWKLTQNFMGILIRNYATATETPKVAVSEQLLLTLASPDNAYYKNEIVKQVDIPTMSGNVGLLAKHVPLLAVLKPGVVKVHAEDGTSRSLFVSSGTLSMNIDGTCQVLAEEICPLEDIDMEAVRAELDDAQRRLSSSTNEMEKAQASIAIEVCEALSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3E7</accession>
    <name>A0A0N4U3E7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3E7"/>
    <dbReference type="WBParaSite" id="DME_0000125001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000125001-mRNA-1"/>
        <property type="gene ID" value="DME_0000125001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000125001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16861" checksum="E8DF7D8ABB9FD818" modified="2015-12-09" version="1">MLPKIARKINEKKRLKQFENSNHSLKDRYYCLQNIRYAKILNPIILASSLLTAIWIILGITRFTLLHHNWHLELVARSVQYMIYSIQIDIVSILLLRKCKTCRAIFSKFSCKKAESDKQLQNSNMIVPLERQGDIYFLGYAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3F1</accession>
    <name>A0A0N4U3F1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5614</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDN55641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3F1"/>
    <dbReference type="STRING" id="318479.A0A0N4U3F1"/>
    <dbReference type="WBParaSite" id="DME_0000125401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000125401-mRNA-1"/>
        <property type="gene ID" value="DME_0000125401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000125401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29248" checksum="66D2E751BDF2D944" modified="2015-12-09" version="1">MGADGGTIPKRCELVKSKKKREKISKDIVNASLWRNCQLSQETLKKPIVACRLGRLYNKEAVLNAILSKKISKHENMKHIRGLKDIKDLKLAENKEFKGNEVDKGDVYKDRNIAPFCCPVTSIPMNGNYSFLVNWNCGCVISEKAINEVKSDICHGCGGPLSNDKLIMLNPSNDLLEIYEAKLLKEKELKKNRKLSRESDNLEATSKLNNDKKAVKRKAPSSSIQNDANASAAYKSLFTSCEEAKRKPAAHWVTYNPLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3G5</accession>
    <name>A0A0N4U3G5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5630</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3G5"/>
    <dbReference type="STRING" id="318479.A0A0N4U3G5"/>
    <dbReference type="WBParaSite" id="DME_0000127001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000127001-mRNA-1"/>
        <property type="gene ID" value="DME_0000127001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000127001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28387" checksum="E3886548199E7562" modified="2015-12-09" version="1">MSIQIFSHPLMRAQLINWYLLMMALSDSIILVGAFFVLTLPRLGETLSFWKATAISYYSAPYMYALMTLAQTISVWMTTVMSIHRFIGVCVPMNSLYRKIFYEWAYTLIMFAVPFTILIMVNSLVIGAVHRSRRIHAEFNIYDDELRKQEFAKEISTSIMLVAIVVAFLLCNTPAFAVNLFEKLDLLELYSTTVPWSNMLVMTNASINICIFCIFSEKYRQLLGKCLKYNRCFKLENDKESISIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3I4</accession>
    <name>A0A0N4U3I4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5649</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3I4"/>
    <dbReference type="WBParaSite" id="DME_0000128901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000128901-mRNA-1"/>
        <property type="gene ID" value="DME_0000128901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000128901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11929" checksum="23514F961B006B64" modified="2015-12-09" version="1">MEGRRLLESLLSARGDDCNRLIEVNQVGNENLTANKSRNSNIVTSNTNDNNTNNSRQRRRISRAQSVAKRLDEHRPPGLFFVLTSNLAGFSSCEDVMANSPERHSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3R8</accession>
    <name>A0A0N4U3R8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA mismatch repair protein Msh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS5739</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3R8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3R8"/>
    <dbReference type="WBParaSite" id="DME_0000137901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000137901-mRNA-1"/>
        <property type="gene ID" value="DME_0000137901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF145">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="315"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="658"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN55766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000137901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="730" mass="83729" checksum="AC2D2198CFD46CF4" modified="2016-06-08" version="2">MDSIDKSLLKILQNKASGTVAIFEKIDFYCCYEEDAFLVANEIFLSEIGLRRITIDTQELTYHNLNNGQYNRVVRDLLLLLHYRLEVYALDDRQWKLKAKVLFDSNLCIKGSLGCLGDFEEMIGDSIEINELSTVMALVLSEEHGSDEYRLSIGFCNVRDVRMTVAEFSDTQHFSNLEKCIVSLTPREFIIVPNISKTMVDRSDMEIWIDHLEIALKRAGVKRVPFQSWENVTVEMENKLFQVINTKFKDIHLSEQQKRCLISLVEYLHIADDATYYDCFQLFNYKSAGHMYLNMAAVRALELFSVSYDEDASFGDTGTLFQLMNKCRTQHGQRLLRHWMRRPQYDLRRINERLDIVEALYSNFTCRAILYDNILRRVPDVTGLTRKLMMKKAGLQDCYRLYQLIRLLRRLEEVLTDLYANSNNLAPSINDLCLEQIRVALLQFEKFARLIETTIDVEYCEQTGTYRIKPEIDEYLLHTAKRMKAIESDCKNLFNKACAKIPEAVKLDYNSQYGFFFRVTLKAEKSLRQMGFRILATSKGSGVRFTNSDLDRLNSEYRELEKIYESSQTELIKMVVNTCASYVPALNQLSETLAILDVLVAFSVLAATSPSKYTRPQLLDKDSSVIELKSCRHPVLESILNASSFISNDVIMGKDPEGANMGGKSTYMRSCALTVLMAQIGSFVPCDSARFSLMDGIHTRIGSCDYQCRGISTFMAEMIDSASILEQSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3T8</accession>
    <name>A0A0N4U3T8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS5761</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3T8"/>
    <dbReference type="STRING" id="318479.A0A0N4U3T8"/>
    <dbReference type="WBParaSite" id="DME_0000140101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000140101-mRNA-1"/>
        <property type="gene ID" value="DME_0000140101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN55788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000140101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18818" checksum="0A347373BE21A58B" modified="2015-12-09" version="1">MKQSKGLEGGHHSHSKESKNLDEVAKQFKEGKTSYGDKRRLSDRSNEEDEEAKKFEVIGVGVIEQLRGNKKENLKKKQLKLAKEFINSFEDSLDVWICPVCSVAYVDGACDMVCCDHCDNWFHWSCVGLVLAPPAEVPWYCNNCAKKKSLKRKSQSSGVSMKKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U405</accession>
    <name>A0A0N4U405_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5846</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U405"/>
    <dbReference type="STRING" id="318479.A0A0N4U405"/>
    <dbReference type="WBParaSite" id="DME_0000148601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000148601-mRNA-1"/>
        <property type="gene ID" value="DME_0000148601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000148601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13866" checksum="3A4CCCBB0610BFDB" modified="2015-12-09" version="1">MSRKFYDNLGGKRVYSCERCRLYLTNREEVMSTDFRGATGRAFLFRRVVNVRESAMEPREMMTGRHHVRDIFCLRCDAKLGWMYEYAVEADQRYKEDFFSKKFSVFFQKLLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4D3</accession>
    <name>A0A0N4U4D3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4D3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4D3"/>
    <dbReference type="WBParaSite" id="DME_0000163501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000163501-mRNA-1"/>
        <property type="gene ID" value="DME_0000163501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790559at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000163501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49522" checksum="EE2C299DCDDB23EB" modified="2015-12-09" version="1">MTITIIVALWRHRLNLFGYRKPADVRIIAVGPISCLTDEQCVDIFYQINCKNQTDHSYLSLAQKVHELASNYGATTRYICVFERDLQETIAKIRFSLDIEGTVPEHVELLLHSRDLKTIAKRNGLITARSCTISSQSIVEKWKEKLIWQIGTFPMFVKAILNDDNRCTRLHYIANSFESLQEWVKAQSNCITELHIEECLQNGNEFIAVCSKLGLIGTIVTTYSKRPVLYNVHKQIPYALEYLPVDKTRDHYPGIESFVLQTTKSVFIKSSYSLLFIRGFYKGHSDIYFMGASLEPPSKTHASLIYLARNSRSWEVLLLENLNFPQNHNGDICSNDSCTYYAVINFPTTEGVLLHQTSIPKHNSQQRVIWRASEGDVMYDATHIDENVLQANIPMDRLCFIDRYHICPRHRQLNQRPYGSNSLVRSSTTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4F5</accession>
    <name>A0A0N4U4F5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS6023</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4F5"/>
    <dbReference type="STRING" id="318479.A0A0N4U4F5"/>
    <dbReference type="WBParaSite" id="DME_0000166301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000166301-mRNA-1"/>
        <property type="gene ID" value="DME_0000166301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824333at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF1">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039123" evidence="2">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN56050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000166301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24422" checksum="F080F1176061924C" modified="2015-12-09" version="1">MRTWLILIMHNVCVHITVSTNLQFAINAERKQIFENTQTQLVPHSNTVRCLSCMSKFYEAVWPSLSAIYKRPKNFTDHCDTENVNINLIPITYCPTICVRMWEEAVVAGIRIKGNIRGCLSEILHNGFNQTIITWYRWMHRDSCRQYRKRELFKLSTEQSDESYVTVCTCYDDFCNAATRSNAPHRSLFMLFLFCFSIIITLLPVYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4K3</accession>
    <name>A0A0N4U4K3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6078</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001154">
        <property type="protein sequence ID" value="VDN56105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4K3"/>
    <dbReference type="STRING" id="318479.A0A0N4U4K3"/>
    <dbReference type="WBParaSite" id="DME_0000171801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000171801-mRNA-1"/>
        <property type="gene ID" value="DME_0000171801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000011">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000041">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF245">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000171801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40626" checksum="7E655142277B0384" modified="2015-12-09" version="1">MGVCQSQEEKIMVQKSKAIDKEMMQGHAAQQKIVKLLLLGAGECGKSTVLKQMRLLHTHGFSEEEIMNQKAVVYNNTVQAMAALLRGMKTLNISFENQQREADARMIFDVIKAGSESEPINSELAAALKRLWMDKGVSKLAYQRGNEFQLPESAAYFLDAVDRISMPDYKPTEQDILLSRIKTTGIVEVKFQLKNVDFRIFDVGGQRSERKKWIHCFEDVNAIIFIAAISEYDQVLFEDETTNRMIESMRLFESICNSRWFINTSMILFLNKKDLFAEKIKKTSIKVTFPEYDGPQTYDDSVRYIEEKFEALNANPEKTIYIHQTCATDTNQVQMILDSVIDMIIQANLQGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U4Z5</accession>
    <name>A0A0N4U4Z5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6251</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U4Z5"/>
    <dbReference type="STRING" id="318479.A0A0N4U4Z5"/>
    <dbReference type="WBParaSite" id="DME_0000189101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000189101-mRNA-1"/>
        <property type="gene ID" value="DME_0000189101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001133">
        <property type="entry name" value="Hectd1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1333"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1517"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1581"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1333"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1591"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000189101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1683" mass="187768" checksum="2CFBE8BF633E0BBE" modified="2015-12-09" version="1">MDNIDPDTLLEWLQTGVDEDREIQLTALEQLCMLLLMSDNIDRCFESCPPRTFLPALCKIFLDKTATENVLEVTARAITYYLDVSNECTRRVTQVDGAIRAICNRLTITDLNDRTSKDLAEQCVKLLEHVCQRETSAVYDAGGLQCVLSLISQHGQRIHKFEIGTKFCIQDTMHSAMSVITRLCSKMEPNDAALPECSAYLGALLENDDPKVSECALRCFGALTDRFVRKAIDPAEMACYGNLVERLLNSLAPPLLPSVASSSLLTGTTHIVNVASSSSIVSADSSSSAILTNQRTTSFIILVISLLSSLCRGSNAVAEQVISSCRLIVAIKNILICKDEHCIVDTLRFCDILIILLHEGRKALLKNCASLSSSTGETADRSRRFHLLDAIRQKDAAALINYMESGQVVKILLQCGNDVEMPEEDFRMPGKETDRRDDDISCLEKVLEAHSKHGTKSKENKKTLPAPMENDDDGNNVGDILNLDHEIVRELLEQFLPIFCDVFQRSIGMNIRRICLSLLRKTIHFMSNSSLDSLLCNTEEENLSIDFGGRGQGLAENIINVLVMALDQEDDIDCHENALNVIKSLFSKNADFWLEQFIRVGVFEKVETIATQPPPVSKGGLVTTMVVDESGHVSSASSVSVLESQLVKAAPNVSMVEDQKSSSEIGVNQKALICNQKNREILDKVSNIITGSTSEQGGLDLSSLLKETNKGRESGLDDDDQWEIVEKESYKWKDWRLMKSRDSLFIWCDAVAIEFSDGSNGWFRFMLDGHLNTMYSSGSPECTEDNVETRAEFIAKLNTARNAVPPGSLLNTVFSLPTNRVIEVGNWLLTSPKNGEVYITNKQGNQQRLIIMEDLPGFVFDSNRQTKHCFQAESTLGLDFVTGWAARGGARRLRFRAEAQKVKLQELALEIYEKYLKEARSKPRDALLKLQKSSAAIKGICETYSTQFLPMSPYNELKASLNCLYNSVINDRLLSTFEFSISKVVEALLSLLLVVRKDLKCSIANVFKKVFSDSRSFHALVRKMVLILEATEKFPQYLYDTPGGSSVGIQLLGRKIRFKLEQINPKAASQGHLLNRTMKIEPLTTAGQLRNYILRMVARQWYDCSRESFNFVKQIVNAKKHGKDISFDYTSDFDERGIIYWLGTNGCTVNDWVNPATVGIVHITTSDGSLPYGRPEDILSRDINALNCHSSDDKRAYFVIDFGVLFHPSYYTLRHSRGYGRSALRSWSIEGSYDGVTYDTLKTHTNDTSLNDPGSTASWPLSYLDSRSLFSLFFMKQLIINQTYYLSVSGFEIYGKIVDVLVDDFKPFEPAEKNQNSAKNRPRKILLIKDRKESKMKKDVAKTENSERASAPPASNIRSEEPTKGMDKSLSDLAFAHLPGGILNNRLAADLRSHSSTHNMALKNRMFRYYQSHLWPPASNDGTKIGSSESVISANERLRKDAESHTGLVGERVRRGPDWKWNNQGGDMEGTICSSLEDGWVDVLWDDGSTNSYRLGAEGKFDVMVIPRHHFKLGYKRGSKSSTVSRRVHATAKQSAQQRQLPPAPRHSMDHTAAGSILRSTGFSPMNSRYFRTNAPLTETLDAQSRDSRAGSVIGTTSSTISQKSMSTTNLLDRAEHEKHYSVASSNQAASAESLQHQTPSLENLLARSKIFGDRIPEVVSDEAYSVTESRENGRACIFPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U571</accession>
    <name>A0A0N4U571_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6339</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U571"/>
    <dbReference type="WBParaSite" id="DME_0000197901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000197901-mRNA-1"/>
        <property type="gene ID" value="DME_0000197901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000197901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9006" checksum="87A349A8D32E5700" modified="2015-12-09" version="1">MMKGSGLDLHDASIPVVYAMNMMNMQYGNSKRLINKVYLRTRVITENLSRNTEVLAIAMWNIGTLTDLVNPGDVREGVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5F8</accession>
    <name>A0A0N4U5F8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase-associated protein LEO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6438</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5F8"/>
    <dbReference type="STRING" id="318479.A0A0N4U5F8"/>
    <dbReference type="WBParaSite" id="DME_0000207801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000207801-mRNA-1"/>
        <property type="gene ID" value="DME_0000207801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000207801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55794" checksum="C744D20874615266" modified="2015-12-09" version="1">MSSADDGSSDADSSSDESKSATSEQSNQNNSEDSDTSDKKTSIISYQSSQENFEISKRDNLSLSQVDNSPQHSEKSTHESKASSVNGSSADRRSRSSRSMSESSDEEDNRKFAAKESVSSSGRTSSSSEKKVQKRAVLSSDEDEKASDNEHNAANKGNDLADIELSDSRSDMTEVSGNKENLDDDIVGTRLYPEPEQEDERPEPAVVEVNTARICPNFNEQGLYFIKVPNFLSIDSHPFDPDHYEDEFDEDDLMDEEGRSRLKLRVENTIRWRYALDENGDIIKQSNSKIVKWSDGSMSLYLGSEVFDIMVQPMQHDNHLFLRQGAGLQGHAVFKEKMVFRPHSTDSVTHRKVTLSMADRSNKSQRVKVLTAVGENPESQKAEIVRKEEERLRAQNRREAQQRRNRLRPMMRSGLSANFLEEKDEDSEGESIAAIKNKYKYGYGDRSMPDHSDSEDSDSRRLHDAKHDSGDTSDSDQEVRKQKKKIIIEDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6H4</accession>
    <name>A0A0N4U6H4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6882</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6H4"/>
    <dbReference type="STRING" id="318479.A0A0N4U6H4"/>
    <dbReference type="WBParaSite" id="DME_0000252201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000252201-mRNA-1"/>
        <property type="gene ID" value="DME_0000252201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE MBLAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000252201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30126" checksum="8368398BAC1C4409" modified="2015-12-09" version="1">MLTLRRNNPYSVEKLSTNIFCIHENDEWEHSPLIYLILGDEKALVIDTGCGTGDLHQYIRSSGIMNILYLILYYFSTGSNWSFSALGKLGLSHNVESLCASSRNKQYTELHSAEFDWQVKPYKITRWLNDCEMIYLGKENEAKNVVKIIHTPGHTPDSLTIWFVVPDNRLFIGDLYYQFNDLQLKYSAAKIDSDGAFLPDFEEYHRFFLLVIAGVQRTLPLKNNEYHCRRYESRDKKIKLIISEQLAIQLDKARGSALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6H5</accession>
    <name>A0A0N4U6H5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS6883</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6H5"/>
    <dbReference type="STRING" id="318479.A0A0N4U6H5"/>
    <dbReference type="WBParaSite" id="DME_0000252301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000252301-mRNA-1"/>
        <property type="gene ID" value="DME_0000252301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN56910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000252301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="52147" checksum="743B097A414C425F" modified="2015-12-09" version="1">MLSISSRSASLSSVYEQSTNSNNPIIKQITVDQIYGIIAISLSAISIVLSFTSLPIFINKLNELQTNTINEFKIIKELSEKVEEDIVELQSQFNIVKISAAALTDDQPPEGYIPFPYQEIQWKAFDDLTGNNENIHDYDELLSILDHKRERDYTNRRIAHKYGPNYIYRPLRTGPNGGDRVRIKGGYIKSRNSGWSSGIMAPSHIPFGHIETDYTVKIDQESCIGKPGAPGLDGLDGTDGEDGVDGLPGADAYEQDDECIICPAGKQGPPGPPGPMGPQGAKGDKGMPGDPGTPGIDNYERGPPGDEGPRGSPGLPGTRGAPGEDVISGIGIPGSPGPPGPQGPPGLPGRNGIPGIVRGGLEGSIGPPGEPGDDGDPGPSGSVGEPGLPGIDAAYCSCPPRNLASYSFYRRDHPRDISLAIPDQNGYERIAMFCIVVLHWLRPNVSGSVPLLLLKREVQVNIFILLYKRFCDKGKQRQVLAKLLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6J5</accession>
    <name>A0A0N4U6J5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS6909</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6J5"/>
    <dbReference type="WBParaSite" id="DME_0000254901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000254901-mRNA-1"/>
        <property type="gene ID" value="DME_0000254901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792724at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN56936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000254901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23546" checksum="108AD9C2480A3FE0" modified="2015-12-09" version="1">MVAAINSPTFDQNDPKYHCCCNKLHLKEGARIVTILCISLTFCNIIYATARGATLALSSWLSSAFAAAIFGCLAYGVFKEKRVYILPYLIFQVTLFIFVFMIGSTVSPKMLRQLADDLVGIDFNMSNEEIISELQTFMIFFLIFLTTSLLLQLWFLDTVYRFREFLKDRENSFTFNLEGIFQTNSSVYSTAEELGCVPDSPNYNTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7C5</accession>
    <name>A0A0N4U7C5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS112</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7C5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7C5"/>
    <dbReference type="WBParaSite" id="DME_0000288301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000288301-mRNA-1"/>
        <property type="gene ID" value="DME_0000288301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN50139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000288301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="818" mass="92228" checksum="B9734BC88D77EDD8" modified="2016-06-08" version="2">MDNDLGDILYRADALCTSTLKGQPLYHLARSGSQIDSLLYNAFRSTESLFHSRSGLDPEAEFNANMLLGERALPEAPEKSAILSQQLQQQEEEPEFISSTGSTELLEDLMQASAEKIRLLAERSFLNQQIVDTTQIKRKALNLTKSSVEPSPSKKRIEDERIIAVTSNAAETAFAKSVIEFYFPLSDYIYDKNEDKLAKAFAGAAARTRDNSVILIWDQVLVLFVSQFSVKGETAKNVRSNTSWMIHVVESSVGYLQKQLVTLSLAFGFINHMELIVERNLAIARRGGNPGILPLINAFLNVKHFKTTETTCQDGVYGTDSHPVWEVVYLCLRCGGFDSVRKIADSHLKNLPSCAALATSLSSLEKGYKLSSEEKTRIKAEWRSESRSCTDIHKKAVYCAFTGDESSEVSDNLENWLWQKLTPCSFDCSFSTAVFKELERLIGNDYGTLDGCYMKMKIIGEDYFTSDGGSPLIFFQALWLTGQIERAISLLYKIDMMSHAVHIAILAYLKGLLIVSDDLSLPIRIYLQLYIEISPDNPMECSLNFCRLILLYIKPFELVNIPQSLDYLFLLRKMDSPIEGNLFLSCVSRAVYLTDEISLILGSVDDRGLRSTGLIDKYAADVIVDDVLAKVAHDSEISGNLANAVRLYHSAKRYDDAIRIACDYLAKEMSNSEKRTQARNLAMWLASIYKRSSDLSSHLISTLYLLIDISTFFLNYQEKKFSKCIDILSKLKCIPLVPDDVQSYVSVFYMLSDQVRIVLPDLCLTTMQITLHQFEHNKEMAEILQSRSKAIIHYIAMVPYRFPTLITSKILQISTQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7H0</accession>
    <name>A0A0N4U7H0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7H0"/>
    <dbReference type="WBParaSite" id="DME_0000293101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000293101-mRNA-1"/>
        <property type="gene ID" value="DME_0000293101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000293101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9167" checksum="657684068F5CB136" modified="2015-12-09" version="1">MRTLAKDIYGKSHIRGFDILASYGLASDEGFCNGVRFSPHGVRAFAYALDKNDALVSCCHQLGFIATHQDWSAAKETQTFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U826</accession>
    <name>A0A0N4U826_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phlebovirus_G2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7331</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U826"/>
    <dbReference type="WBParaSite" id="DME_0000317201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000317201-mRNA-1"/>
        <property type="gene ID" value="DME_0000317201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000317201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11926" checksum="17B3348865479C34" modified="2015-12-09" version="1">MSITTIYVSCQLHWCCEISCPSRIFDAFVCPVDLFELTTVHESSVWTATISTRKLQPQQQYQVNWYIQFWQLKSDVKQQIAHDEDHKASTAALTITINSDNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U865</accession>
    <name>A0A0N4U865_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7375</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U865"/>
    <dbReference type="STRING" id="318479.A0A0N4U865"/>
    <dbReference type="WBParaSite" id="DME_0000321601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000321601-mRNA-1"/>
        <property type="gene ID" value="DME_0000321601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000615">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000321601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26017" checksum="D05A7DDD2F365213" modified="2015-12-09" version="1">MAEQMKLKGMLKGHGDWVTQIATNARYPNMIISSSRDKTIIVWKLDADDAMSMPLRSTDDPLQPQVQLGGKAERALRGHGHFVSDVVMSSDGQFALSGSWDKTLRLWDLSTGQTTRRFISHTKDVLSVAFSVDNRQIVSGSRDKTIKLWNTLAQCKYTISVVSADCHSDWVSTVRFSPSSANPVIVSAGWDRVVKVWNLANCRLKTNHYGHSGYINTVTVSPDGSLCASGGKVLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9I4</accession>
    <name>A0A0N4U9I4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS7759</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9I4"/>
    <dbReference type="STRING" id="318479.A0A0N4U9I4"/>
    <dbReference type="WBParaSite" id="DME_0000375401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000375401-mRNA-1"/>
        <property type="gene ID" value="DME_0000375401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14233">
        <property type="entry name" value="GAT_TOM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN57786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000375401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33144" checksum="E3492E6283A1F994" modified="2015-12-09" version="1">MKNYLQSWNDAFRGEPRLQGVCQVYEELKAKGVEFPMTNLDNMAPIITPKRTVFSTPTDRLTDSNFSHAVPQNILDPSQHVRPTSKQLEKLRKELDIVNNNLKVLREMLSELAPGKEQPDDMELLVELHAVCKQMQQRILDLIRSIVNEEVTYELLILNDEFNNVFEKYDRYMSNRSSGNKASDSQLVDTEEQRFNEQLEAMHITNARHTRQSTETIYAENSTRLDQAKIGLAKAAFNKSALMSDREADEISQWLEAQETKCNPTVRNPDVPTEFDPLIKKDDKNDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA51</accession>
    <name>A0A0N4UA51_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS369</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000003">
        <property type="protein sequence ID" value="VDN50396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA51"/>
    <dbReference type="STRING" id="318479.A0A0N4UA51"/>
    <dbReference type="WBParaSite" id="DME_0000400501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000400501-mRNA-1"/>
        <property type="gene ID" value="DME_0000400501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000400501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8850" checksum="D0BA390F0CAAEA91" modified="2015-12-09" version="1">MHPNQAGFRPEHDCADQIFTLRRVLEDRFRYLQPTVTCSIDFATAFDSIDRAALWRMMERDGIQEKIIRTHKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAH6</accession>
    <name>A0A0N4UAH6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YLPM1-like spectrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS8035</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAH6"/>
    <dbReference type="WBParaSite" id="DME_0000415201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000415201-mRNA-1"/>
        <property type="gene ID" value="DME_0000415201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860800at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058903">
        <property type="entry name" value="Spectrin_YLPM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26583">
        <property type="entry name" value="Spectrin_YLPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YLPM1-like spectrin repeat" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN58062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000415201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37557" checksum="B5C2D90D6841DBC0" modified="2015-12-09" version="1">MSKRLSPEEELEKQYRDYKAQFEQWKEKNKNSVGTEAYIAYVEQFEAWERDVDRRREMIRSKTESEASESQATQVKTQTSGATEGKRKKEQDLKGEQQRKQQLEAEAAAQAVAYAKHQQSYLAHHQAALQKEHEMRQASATSVVSQESVKTLDSKPPGIMFHLYRNKNFLRFLLPEKFREEIDSIVYFLEPIDANQVAETMKQMAQLAQVMMNDQHDQHMDSDAIYQHSLSTHSVIQPQHPAPPPQLWGNDRAIYDSNDPLFKKWGMRAAPPYHKPAYRPPPPEYQIPPCWLFLEQMKEEKLIIAPQVNLPPPILPKFAVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBF4</accession>
    <name>A0A0N4UBF4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hornerin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8413</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001168">
        <property type="protein sequence ID" value="VDN58440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBF4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBF4"/>
    <dbReference type="WBParaSite" id="DME_0000453001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000453001-mRNA-1"/>
        <property type="gene ID" value="DME_0000453001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805706at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000453001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25428" checksum="8F7467CA8E1F08CA" modified="2015-12-09" version="1">MALRRTERSAISSNSDLAREFEHDSKWEDSFGGHDSGYIFKKHSEINNDRHGHYDAGKAENEEHAKILKSGGGKHAVAAAEGGIEKHSDGANARGKDVKAKTFGFFDYFYKQPEYHIEQFYTDEKHGHRFGADHRNKAVKDHSRDLHEAAEWNKQQNRHHSGAFGAETQSHAANEHSNWNHDRHKAYNHEKSQSFAKGEHSVSSEVHSNSPGQQEHHTYGHLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBJ4</accession>
    <name>A0A0N4UBJ4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DME_LOCUS8459</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 9"/>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBJ4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBJ4"/>
    <dbReference type="WBParaSite" id="DME_0000457601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000457601-mRNA-1"/>
        <property type="gene ID" value="DME_0000457601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000247">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDN58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="DME_0000457601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="659" mass="75487" checksum="4E35D9C2A690727B" modified="2015-12-09" version="1">MLRSLSQSKIAKALAGVEMEETEVMEMDEGRTAREEGRVVFECSWEVANKVGGIYTVLRSKAAISTEELGDQYCMLGPLREDRWRLEVEQIAPESRNIATAIHKMNDSGFRAIYGRWLIDGYPKVILFDLGSGSYKMDEWKQELFDRCQIGIPYEDIESNDSVIFGFMVAIFLQHFVQSVNGYRILAVAHFHEWQAGVGLIMSRLWKTDVATIYTTHATLLGRHLSAGGSDLYNNLDKFNLDEEAGKRRIYHQYCLERAACHMAHVFTTVSEITGVEAEKLIKRKPDILTPNGLNVVKFAALHEFQNLHALAKEKINNFIRGHFHGHYDFDLEKTIYVFTAGRYEFTNKGGDMFIEALARLNHYLKTTRELRHKEVTVIAFIIYPARANSFNVESLKGQAVTKQLKETVDKIKENIGQRMFESCIRGRLPDMSEVMDATEKIQLKRCMMATGKQELPPVCTHNMIDPNDPVLCNLRRTQLINNRADRVKVIFHPEFLSSVSPLIGLDYEEFVRGCHIGVFPSYYEPWGYTPAECTLMGIPSVTTNLSGFGCFIQEHVIDPASYGIYVLDRRFKDAEGSIWDLAQILYDFCGLSRRQRIIMRNRTERLSELLDWKSLGIFYRNARRLALERLFPNLDEIIKDNEGKVPPAAVSRRGSHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBL2</accession>
    <name>A0A0N4UBL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBL2"/>
    <dbReference type="WBParaSite" id="DME_0000459701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000459701-mRNA-1"/>
        <property type="gene ID" value="DME_0000459701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869373at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000459701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7816" checksum="74AF5083DB504697" modified="2015-12-09" version="1">MRRYTIDWIIESAYHDSRSVSPVNPEHCTTDFEYADDLILFADSYDEMQVMLNKVSDTAVQQSPIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC69</accession>
    <name>A0A0N4UC69_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8732</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC69"/>
    <dbReference type="WBParaSite" id="DME_0000484901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000484901-mRNA-1"/>
        <property type="gene ID" value="DME_0000484901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000484901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26048" checksum="AD59CFF92B06BA8D" modified="2015-12-09" version="1">MNNKTIENEDNEKIQQNKGKLVENEETKEKSLDENFQKINRSMEKGRTPFTISLVDLQERITQPVSRIVEPQMSDANLLSPTSDQSAEQKNNETEKKLPKTPAMLRVRNTADTFFHYRSPVDFKRPDGSIDNPCLKHFFSRNPLAPRMPGTLQNRSERRSFGDLKKKHGKEMIGPQKEIMKVLEDKVAEAEEEIEEKGEKVESQKEELNADEMSLEDEKTKKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UD28</accession>
    <name>A0A0N4UD28_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Parvin, alpha a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9006</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the parvin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UD28"/>
    <dbReference type="STRING" id="318479.A0A0N4UD28"/>
    <dbReference type="WBParaSite" id="DME_0000520701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000520701-mRNA-1"/>
        <property type="gene ID" value="DME_0000520701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000015">
        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="104"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="272"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000520701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43472" checksum="FCAFBFDEE780C66A" modified="2015-12-09" version="1">MARVGESTIVQQSRNTLRKDKKSVKIFKDESLLEKLGTLGRKKKTVQQMEQEAENEAIEVEIEGADALDSAVIPVAATPQSLILEEGEQKRFLTVESRDDPQVQSVIQLLINWLNEELSSQRIVVKHIQEDLYDGQIIQKLIEKLANIKIEVPEVSQSEEGQRQKLHIVIETINRIIAQGQYEQTKWNADNIHNKDVVAIIQLLVAIAIYFRAPVRFPEHVKANVLVVQKKDNQIKSHYLTEQLTTVQTELGMKGERDAFDTLFDYGPDKLAHVKSSLLAFCNKHLNKINLEVTDLETQFQDGVYLVLLIGLLEGYFVPLYSYFLQVTSHEQKIHNVSLAYQLMNEAGVQKPRARVKDIVNGDLKSTLRILHSLFTKYKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDC2</accession>
    <name>A0A0N4UDC2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch motif family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDC2"/>
    <dbReference type="WBParaSite" id="DME_0000532101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000532101-mRNA-1"/>
        <property type="gene ID" value="DME_0000532101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867838at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000532101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37951" checksum="9816AA0DA817B173" modified="2015-12-09" version="1">MVLERIGDSAGKVLENTEEYHNYVSCDDKIWIFSKKYTPQSTFNYGHRISFGGGYAASFDTISRNWSPKIEFPAVSLEENLEEKIFVLNSAILMLLYSHFGGIKFHSLFMWNIEKMQWSNVDKFVESIDNPDAQAKSKLIIVHQIDEIDRKSMFFISSIRNSLYVHKLLFNNKHSASISIVNTIENFEKTPVVAARWNNEIYMFGGISGCGFRFDPKSCFIIDIAKKQTQEIEMENDHPAFSFNGPRYNYVTKNGRWYHATGMTQVGMTGSIFNGEIWYIDLNETIIKWFKAPLVIPKMDVDFMRIDENDFIFIADKNEGVFKGEIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDE9</accession>
    <name>A0A0N4UDE9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS9155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001177">
        <property type="protein sequence ID" value="VDN59182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDE9"/>
    <dbReference type="WBParaSite" id="DME_0000535601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000535601-mRNA-1"/>
        <property type="gene ID" value="DME_0000535601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804999at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058430">
        <property type="entry name" value="DUF8117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26431">
        <property type="entry name" value="DUF8117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8117" evidence="1">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN59182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000535601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29169" checksum="7BDD96A47125B95E" modified="2015-12-09" version="1">MQTYKFKMYEKLSRIWWSRLVISVRGYVANYVENNDEILFHCDDAFIMVHQNIVESTVDCAQQFLLDLETVVNIPEIITILDKLNKGDLHQNPFSDKSTSQQFTSEKASLRIFGQANSVTYRIANAQILAYLIFMHTLTKLQQRWLVSIRKRKSIRFEEDPEWQPDDRVVLFQNFFQGNPTKSMWRPNGSSVIFGDRFIEEKKKLGYTLCSYCGILEQYIGQFAEYANKRYCSQKCLDESCDQTNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UDU8</accession>
    <name>A0A0N4UDU8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sodium-dependent multivitamin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS9264</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UDU8"/>
    <dbReference type="STRING" id="318479.A0A0N4UDU8"/>
    <dbReference type="WBParaSite" id="DME_0000552301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000552301-mRNA-1"/>
        <property type="gene ID" value="DME_0000552301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000552301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52540" checksum="D8AFF20A5C358074" modified="2015-12-09" version="1">MTISLVDYAVFIFSLSLSVCTGVYHAIRAYYSKSELSKNEEYMMGGKNMPAFPVALSLLTTFLSGILMLGVPAEMFQRGANIWMNFIVGVIASLLTATIFLPVFYKMKIFGMITTLYTTIGGLKAVVWTDSLQALLMYGGVFTLVYVGLQNPKVGGFNRVWNIAYNTGRIQDAWRNEFTIFQLAVQRYFSLPRFSDATKIIYHTIIPFLLLCSLVAFIGFIALAYYFNCNPLETGEINDSDQLIILFAREVLTPTRGLFGLYVSCIMSATLSTLSSGMNSMAAAIYEDFFKKNLYGKISDAKTATMNKIIVMTIGILSTSLAYSAEPLGGILRVCISVMGATGGPFVGIFVLAMFWPKAGEKSTFISFVSSCIIMMIICIINYIEDPYGQYFLETNSTREGCKNINFTRRALPPYDAYYGNPEKSLISRISTYSYPGIGMIIMLIIGASLTHFWKEQNPEEIKHLTFYGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UEW8</accession>
    <name>A0A0N4UEW8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS886</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000009">
        <property type="protein sequence ID" value="VDN50913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UEW8"/>
    <dbReference type="STRING" id="318479.A0A0N4UEW8"/>
    <dbReference type="WBParaSite" id="DME_0000594701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000594701-mRNA-1"/>
        <property type="gene ID" value="DME_0000594701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867484at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000594701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13974" checksum="311A710FE67909DE" modified="2015-12-09" version="1">MSRSSVTMHQLCRQISRDKDKSYSELQLLTKSHNMVLIGRDWNVHVGHNVAAMILTIGKYGIGDRCANGERLRYAEEYEFFVANTCFRHRKKHLATWNSSDNQHFNQIGYISVAVRRVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UF91</accession>
    <name>A0A0N4UF91_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS1029</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000012">
        <property type="protein sequence ID" value="VDN51056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UF91"/>
    <dbReference type="STRING" id="318479.A0A0N4UF91"/>
    <dbReference type="WBParaSite" id="DME_0000609001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000609001-mRNA-1"/>
        <property type="gene ID" value="DME_0000609001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN51056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000609001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26066" checksum="2728B03A8680B777" modified="2016-06-08" version="2">MLLVSNIYSNPTCTGTTVVAIAYKDGVAIMTDRLVSYGKMARYRHFCRQYRVNSRVVVAFGGDHADFQWLQNLIERQTFRLKAHDPTAELSPRMLHGYLTSLMYIRRTKLNPLWNILVVAGMQMQNDQFEPFIGVVNQRGVAYSTKSVATGLGAWLLNEMVENELRQNGEKLTTISLLRKSLELSFYSDCTTSNEFDISIVDNEGVKLRKPETIVGNWDIAEYRCDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UFT7</accession>
    <name>A0A0N4UFT7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1216</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000016">
        <property type="protein sequence ID" value="VDN51243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UFT7"/>
    <dbReference type="STRING" id="318479.A0A0N4UFT7"/>
    <dbReference type="WBParaSite" id="DME_0000631901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000631901-mRNA-1"/>
        <property type="gene ID" value="DME_0000631901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10525318at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000631901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22064" checksum="E371CF461A83966D" modified="2015-12-09" version="1">MKTKKPVIITISDDPGNALLAFSLSFKKVQRVRPTRKRKKRDIKLKKQLKIRSLPNINEVKEDTHDYCVHQVLNKEKMTMKRLRSNSFCPSALQLPSSSLIINDCANNEMTEQTKKIHREEVCLVVVFSDVFHHMVHGLSLKIAPTLLDGDSVNNATSAFYKSIDAMPNMNVAKTKKTIPLVSELVGTEGKLYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UGB4</accession>
    <name>A0A0N4UGB4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS9635</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001187">
        <property type="protein sequence ID" value="VDN59662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UGB4"/>
    <dbReference type="STRING" id="318479.A0A0N4UGB4"/>
    <dbReference type="WBParaSite" id="DME_0000652401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000652401-mRNA-1"/>
        <property type="gene ID" value="DME_0000652401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000652401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="48919" checksum="7FEBEB386A21C150" modified="2015-12-09" version="1">MSNERFNGWAYLPDNLLEEIFFLLPIKNISRCSQVCSNWNRIAKSKYVWQKFKFKDYAFTRRKFTSHYGWQHVIDHWRLRLLILNAAEKWRKLEVEPVTILFNLYEFFRVLINFAEYYEKNTTYRPLTTIRSFSFKWQLHIHQRGEDQREQMFGTGGEMLKALSLLLSYLHGLTDLTLRELQLESYECNNFIDDILFKFNQQLTSLCIVNITKAARAFLQFGLFLNLKRLVISAQHLDESIVILLADLYNLQVLVLYQVWHFNFIRYLILQPKAPVYAIIHEKSTGQLTSETAQFNYSETLQYYIQEGLERHYRSRRFVDRVDLFLIQMAICSNLKLLVMRERVNYMTAILLALTARQNNTNICLRRNALLKRVFFFLKIIFNVKYFIIPVILLTRSLFENLILVSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UH69</accession>
    <name>A0A0N4UH69_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS1488</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000022">
        <property type="protein sequence ID" value="VDN51515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UH69"/>
    <dbReference type="STRING" id="318479.A0A0N4UH69"/>
    <dbReference type="WBParaSite" id="DME_0000687401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000687401-mRNA-1"/>
        <property type="gene ID" value="DME_0000687401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="7">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN51515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000687401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38835" checksum="CA58C789DDDAE4B8" modified="2015-12-09" version="1">MGHFLESLRQAVAAMCMQAGFETVESDVLEILTHMINSYLLELGNTTRQLTELAGRTVSTPHDAVMALIELGTRVMDLPLFLNDCSNHGTLVIGPPKLPPIVTTPNALRVGATRFHQSFFSDGLPALPDPHTYIRTEISGEPELTYEKVRDDFANLKRNSEYSLKDFMLRIHPSVSLFNSFENMLRRQAKQILSQQILHGSTRILEEKEIKQESLNGIENNAVEPVDSFNGTEIKLENSFMDCSTSISAISSDPFLLDDTEISLIRKKLPTYCQIIESNLDNRPYFGASLCDELGEDHAEMSSPELNADNNMVGNNAPVDEETVQDVNPYLQISRMAVLNRDSKELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHF9</accession>
    <name>A0A0N4UHF9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AMP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS9786</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001191">
        <property type="protein sequence ID" value="VDN59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHF9"/>
    <dbReference type="STRING" id="318479.A0A0N4UHF9"/>
    <dbReference type="WBParaSite" id="DME_0000698701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000698701-mRNA-1"/>
        <property type="gene ID" value="DME_0000698701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000698701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43497" checksum="28F1F176DE27F83A" modified="2015-12-09" version="1">MLCRFLQLNKRCLSNQRLAITSTEFVERRQRIIGCVKEQTSNISSNKPIVVVLHAPSRQFCAPDVPYSFRQCSYFRYFTGLVEPDSVLMITAEPGKKSLSTLYINRRSEQEELWEGPNESHEAIFKTSGISDIQDKQKFIPDLEKIIRNSIASFDMKQFYLKDQIAELLATSSFVIPLREIVDTLRWIKSPTEQNLMRKSCRIGSQAINAMICNSRCVTNENEIVGRLEFEVRRRGASWLAYPPVVAAADRANIIHYLNADQTISEGDTILVDAGCDYQGYISDITRVFPCSGQFTPSQLMLYNTLLDAHLFLIKFAKSTRPLKLNDLYLAMIDKLAKNFSEIGLFTRNLSENELFHVCFYFLFILFIFPMCGHDLSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHN1</accession>
    <name>A0A0N4UHN1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallothionein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS9830</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001192">
        <property type="protein sequence ID" value="VDN59857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHN1"/>
    <dbReference type="WBParaSite" id="DME_0000706901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000706901-mRNA-1"/>
        <property type="gene ID" value="DME_0000706901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10441335at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN59857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000706901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7551" checksum="77AD7A6C9C58894B" modified="2015-12-09" version="1">MARAQFKETLDNSRADVSILSTEAASTMSKPAVSHYCCECVATLNRCAVDSCPCFAARRMCDEHCESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHP3</accession>
    <name>A0A0N4UHP3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1609</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHP3"/>
    <dbReference type="STRING" id="318479.A0A0N4UHP3"/>
    <dbReference type="WBParaSite" id="DME_0000708301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000708301-mRNA-1"/>
        <property type="gene ID" value="DME_0000708301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="78"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000708301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24264" checksum="D40B9D8775CEF6BE" modified="2015-12-09" version="1">MIVIEGDLPMLSKNWTEKNEAHLVGQILADNCKELDRISFNLFYGKLLDSLRQIRGYWELCEQVEERRKQKYDRKNPDHEKRLWTLLMPDHELIGSRSKKWQEIGFQGDDPGTDFRGMGVLALDQLLFFAQYDVASAQFLVHRVFHSFRFPMALAGITLTAMARKLLMDGYLKNHFYNTIKGPPTMDNFHHAYCEVLSSHLCNKKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UHT6</accession>
    <name>A0A0N4UHT6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DME_LOCUS9864</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="UYYG01001194">
        <property type="protein sequence ID" value="VDN59891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UHT6"/>
    <dbReference type="STRING" id="318479.A0A0N4UHT6"/>
    <dbReference type="WBParaSite" id="DME_0000713401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000713401-mRNA-1"/>
        <property type="gene ID" value="DME_0000713401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDN59891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="DME_0000713401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42730" checksum="F95890C536C43329" modified="2015-12-09" version="1">MGIKDLTKVIGDHSPNSIKLNELKSYFGRKVAIDASMCLYQFLIAVRQDGNQLQSEDGQTTSHLMGMFYRTIRMIDNGIKPIFVFDGKPPQMKSSELSKRAERRNEAEKSLNVAAEEGDLVAVEKFEKRLVTKEQNDEAKKLLKLMGVPVIEAPCEAEAQCAALVRSGHAFATASEDMDALTFGSNILLRQMLTSEAKKLPVKEINLAKVLQDFELNMSEFVDLCILLGCDYTNTIRGIGPKKAFELIKKYRNIESVLENIDKNKYPVPENWQYVEARRLFSKPEVGDLKDVNLIWSEPNINGIVEFLCGEKNFNEERVRNSLSRMQKGRQSSQQGRIDSFFSSCKVISSEPTSLKRKVVEKTKSKAKNGNVAKRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIN8</accession>
    <name>A0A0N4UIN8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 9">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS1766</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 9"/>
    <dbReference type="EMBL" id="UYYG01000031">
        <property type="protein sequence ID" value="VDN51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIN8"/>
    <dbReference type="STRING" id="318479.A0A0N4UIN8"/>
    <dbReference type="WBParaSite" id="DME_0000747301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000747301-mRNA-1"/>
        <property type="gene ID" value="DME_0000747301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000747301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51956" checksum="B89F410E7A20AE7A" modified="2015-12-09" version="1">MKESLEKISSDSRSSHDSNIFLSLFEQYLNEPSTVNWSKIKPLGKAYEIEYDNLRKYETNEDSAILKRLCVIKLNGGLGTTMGCNGPKSLIKVRDGMTFLDFAIKQNEVFNETHESCVPLILMNSFSTDSAIREAINLRKSNIRQFMQSKCPRIYADTLAPLPKGADDPLDRWYPPGHGNIFQSMMFNGILDELIGEGRDICFISNIDNTGATIDLTIAKFMANSDVQYLMECTDKTANDSKGGTLVEINHGIMHLEIPQVPKENIEEFCSLRTFKIFNTNNIWVNLSSVKKCLPTMKMEIIVNKKKLSSGENIIQLETSVGGAIRNFDRAYSIKVPRRRFLPVKKTQDLLAIMSDLYEIADDFSLRLRSNRPIPHQPTIKLSSHFNMLAEFHCRFSSIPSLVDLTHMVVDGNVYFGSDITLKGDIVIIADDGEELTIPARSFIENKLLRGRLKFKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIQ2</accession>
    <name>A0A0N4UIQ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS10078</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001201">
        <property type="protein sequence ID" value="VDN60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIQ2"/>
    <dbReference type="STRING" id="318479.A0A0N4UIQ2"/>
    <dbReference type="WBParaSite" id="DME_0000749301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000749301-mRNA-1"/>
        <property type="gene ID" value="DME_0000749301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8956628at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF23">
        <property type="entry name" value="RAB11 INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN60105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000749301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16445" checksum="8D461FFACD2FCF2B" modified="2015-12-09" version="1">MEPNNLIVTVISARGLSLKGHTKLDVFVNLTLNSTGSWKSKVQTEIKKSTGDCTWDQACEFFVNDMDSVLTILVNHKTVIGAECIGGIELKLRECRCKTMPIWFKLRKKGKFDEVSEKYRGELLLKFYFCNKQLSSSALSINSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UIV1</accession>
    <name>A0A0N4UIV1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS1818</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000033">
        <property type="protein sequence ID" value="VDN51845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UIV1"/>
    <dbReference type="WBParaSite" id="DME_0000755101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000755101-mRNA-1"/>
        <property type="gene ID" value="DME_0000755101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN51845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000755101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11193" checksum="96D86F22482F88D6" modified="2015-12-09" version="1">MILEIWMIAEYLYSQVTLWWNVKVFLTWHPMFHGAPCLTVHAISILQSVCSQTTSRLVYTIGSRTRIMLKTCPAKRLSAHRASRSRVEGQSVDGVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UJ68</accession>
    <name>A0A0N4UJ68_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10119</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001202">
        <property type="protein sequence ID" value="VDN60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UJ68"/>
    <dbReference type="STRING" id="318479.A0A0N4UJ68"/>
    <dbReference type="WBParaSite" id="DME_0000768501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000768501-mRNA-1"/>
        <property type="gene ID" value="DME_0000768501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="91"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000768501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44689" checksum="7F45A1A04F11700A" modified="2015-12-09" version="1">MGEPNLLTETSLFDKIKGIVTTLLFLFSSVFGSFYILAPLLPLMFINHVAWRKIIDRLIGFWIFMPAGIIEFIFGVRITATGTKIDHSEPSLIIMNHRTCLDWLFFWNVLIRMDPWLLTSQKISLKSIVKYLPGAGWSMECGAYLFLDRSFDQDQRRIDALIDYYVSCGYNYQLLLFPEGTDKCKRATERSRIFAEKKGLVHYAYVLHPKLTGFAFSVNKMRKVGYIKNIYDVTVAYADSIVQSELALLLKGACPKNVHFDIRKHDVASLPASDVELSQWLIDLWAKKEIRLSNFYSEECLSKRRLDTVDGAEIFLLKDSVRCFIIFVMFCWIILIILWSYIFFTYPSQFLLGFFTFLVFFGAQICFGGMEWIAARIVGNKCKGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK35</accession>
    <name>A0A0N4UK35_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitogen-activated protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS2183</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UYYG01000049">
        <property type="protein sequence ID" value="VDN52210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK35"/>
    <dbReference type="STRING" id="318479.A0A0N4UK35"/>
    <dbReference type="WBParaSite" id="DME_0000805801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000805801-mRNA-1"/>
        <property type="gene ID" value="DME_0000805801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN52210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000805801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39583" checksum="3167B5647F765687" modified="2015-12-09" version="1">ENSNFSYYTKENNLTVVNGIGIECKADDVLTKKTFAIKKIVHPFLTTVNAKRTYREFILLTTMKHPNIINLESAFTPQHSIIDFEEIYFVMEFMNYNLAQVIRQLKLDQQNLSYFTYQLIVAIKYMHRSGIIHRDLKPTNIVVNDKCVLKVLDFGLARKMETTERMSMYVVTRHYRAPEIILGLPYTEKVDVWAIGCILAEMILQKILFPGTDRIDQWSKITNILGSPPKEFINRFNSFMLTFCVLNSEAQRILIVNARDLLTKMLKIDPNERISLDEAVQHPYIHIWFAESEWNAPLPQNRYDIENDLMDRPIEQWRELLYNEVKQFERNHEVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK50</accession>
    <name>A0A0N4UK50_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2202</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK50"/>
    <dbReference type="WBParaSite" id="DME_0000807701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000807701-mRNA-1"/>
        <property type="gene ID" value="DME_0000807701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275812at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000807701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20042" checksum="7E6EB4ABBFF95813" modified="2015-12-09" version="1">MIDWIMGTACRHSRSVQISPEHRITDLEDADDAVLFVESYDEIQIMLNNVSTTAARIALRISSIRASPSLVRAHRRPPQELTHVSLFAKPCDDWRQKRGGPINTWTDTVRKDFERIGPAIYGLRRWKKEWLPLLSTMASDHTAWKRLTLVDDQRYINLDDGFYYCKRWRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UK69</accession>
    <name>A0A0N4UK69_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS2222</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="EMBL" id="UYYG01000050">
        <property type="protein sequence ID" value="VDN52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UK69"/>
    <dbReference type="STRING" id="318479.A0A0N4UK69"/>
    <dbReference type="WBParaSite" id="DME_0000809701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000809701-mRNA-1"/>
        <property type="gene ID" value="DME_0000809701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN52249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000809701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49322" checksum="F155534F49D93BA8" modified="2015-12-09" version="1">MVFSNVVRFFFIVNSKGFIAISVILMLAEVILCTAIIWNIPYTEIDWSTYMQQVECYLNGTYDYSLINGSTGPIVYPAGHLLIYRLLYALTDKGLNIRRAQYIFEALYMANLLAVFAIYYRSSKIPPFVLIPLCTTSYRIHSIFLLRLFNDPIAMFLFYVGVNLWLNHYWIFGSLFYSLAVSVKMNILLFAPAVFFIFLLHRGIRKTIKLLFFCGLIQIAVALPFLMHDSLSYLKRSFDLGRVFLFEWTVNWRFLSESGFLDKRFHLLLLILHAVLLIIFAGLFWFRDSGGLPRSLLKVFRGIGVKTSTNDILFALFTANFIGIAVARSLHYQFYIWYFHSLPYLLFSSIRSDHENKSFFAEYDQSWLSIILRLSILFGMELCWNTYPSTPLSSGMLHVLHLCIFIIVVLDERSRSQGCKYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKP4</accession>
    <name>A0A0N4UKP4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10336</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001212">
        <property type="protein sequence ID" value="VDN60363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKP4"/>
    <dbReference type="WBParaSite" id="DME_0000831901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000831901-mRNA-1"/>
        <property type="gene ID" value="DME_0000831901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000831901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30917" checksum="02E884AA0705477E" modified="2015-12-09" version="1">MSESISNLNINSSIDETSEIEKEIKDNSNLSTPHQTFDYTQNTLSILNKTLNQRKYYANVMKKDVTNSVFDVFDDINRKESFCSLGIFIKYKLNWSKSLSSSPTVDYVTNSSEKFNIERDFKGQFEEMNSEVSQSSILVDSDNDNDNGDDDLDVAISGKRAVVDPLPSMSSGDTRNAMAESNKSATYRTFEKIGYLSADVRKESAEEQFNRVGPDAPADTVTFTADPDELYVPQCERNGSVVDLFCDMLADERFTQTLFSHFLTNEEMQIAKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKU4</accession>
    <name>A0A0N4UKU4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2382</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000058">
        <property type="protein sequence ID" value="VDN52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKU4"/>
    <dbReference type="WBParaSite" id="DME_0000837601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000837601-mRNA-1"/>
        <property type="gene ID" value="DME_0000837601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790750at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000837601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20704" checksum="4F3203BE2939149B" modified="2015-12-09" version="1">MKSQWRLDCTNRQYCSEYRRYEWIERKSQADQLAKLTRIQRNGGYVRKTTQLHHLLKQREYFCNEIHSTGFMFQNFQSYNEWPMTCLWNGGELNGTCAPAPPFEESFGFIEPQIWRNKLYILHDKKKHLQNFRRNIGCSHHEIIQAKLYLPIFFDQSFTSSRFIGRRIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UKZ8</accession>
    <name>A0A0N4UKZ8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DPPIV_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2418</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000060">
        <property type="protein sequence ID" value="VDN52445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UKZ8"/>
    <dbReference type="STRING" id="318479.A0A0N4UKZ8"/>
    <dbReference type="WBParaSite" id="DME_0000844301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000844301-mRNA-1"/>
        <property type="gene ID" value="DME_0000844301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843947at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000844301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24819" checksum="13987D36B717F53E" modified="2016-06-08" version="2">MVHSFHIGHSYSDRNVKIFPHSAKGEYDDPYDLMSTANALMHPSQYGLSGPGLNGPHLNYLGWLPMDRIFYFGRDGRQNHKIRVSSLSVPHKNTMHWLLIMIPYDRDDPENVFTVELRTPIMHDSGIKQASIIIHRISQIGSSYYSIIITHSNEFYELTEGTEWVHFIDYDSTGKYQFIRLSVVKINLTEHYADLKIISTFDPVSVPWFSIKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UL15</accession>
    <name>A0A0N4UL15_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS2439</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000061">
        <property type="protein sequence ID" value="VDN52466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UL15"/>
    <dbReference type="STRING" id="318479.A0A0N4UL15"/>
    <dbReference type="WBParaSite" id="DME_0000846401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000846401-mRNA-1"/>
        <property type="gene ID" value="DME_0000846401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF138">
        <property type="entry name" value="ACB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN52466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000846401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="14039" checksum="57EF6F8E9A66729C" modified="2015-12-09" version="1">MPLSELTKKWWDLDFNIAAEEMRRLAKEPKEKEKLQLYGLYKQAVHGDIPPKDDYPIPVNDEWETKKYDAWKAQRGKVREECEKEYVKLAERMIKKYERNIKRSKWNSEVWTVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULJ6</accession>
    <name>A0A0N4ULJ6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS2589</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000068">
        <property type="protein sequence ID" value="VDN52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULJ6"/>
    <dbReference type="STRING" id="318479.A0A0N4ULJ6"/>
    <dbReference type="WBParaSite" id="DME_0000867401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000867401-mRNA-1"/>
        <property type="gene ID" value="DME_0000867401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001319">
        <property type="entry name" value="Gastrulation defective protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000867401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57398" checksum="D9F75033DF6C3A48" modified="2015-12-09" version="1">MKHGHKPVSALAFDHQGTRFASGGFDYIVNLFEFQKMDLSLRSSRELSPCECHVINCLAFSPNGEYLLVGSGHAQIRILDRQGKQWAETVRGDQYLVDLSNTKGHTGSVNACCWHPLIKNEFLSCADDGTLRIWSLEDFKEITRCINKQRKVIKTKTAGGKRAIPTTCVYSRDGKLIAAGCNDGSIQIWKHGSFYVNTSYLNRKAHCASVTCLQFSPSGEHILSRSLDGTLKMWQLNNFKEPVQEVKDLPNDFISTDCGFSPHAEIVFTGTSYIEEYNVDGCLLFFDSSNFELVYRIEFPKTSCTKVLWHPKLNQILIGLSDGSLRLFYDLRSSVRGAVECVSRPLKRARQQEVVKEEMILSPLTLEMFQPRGEEGEEKEVTAWRLKKYLRMQDNRLRPEFRKPADMPMSGPSSGGRVASSGGTLHSYIAKQVGTKRNQDFLADNDVRASILRHAEENPYYVTKAYLKNQPVTIFQEKTTAPEEEDDTEADLEPVYKRPKKRNYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULK8</accession>
    <name>A0A0N4ULK8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS2601</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000069">
        <property type="protein sequence ID" value="VDN52628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULK8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULK8"/>
    <dbReference type="WBParaSite" id="DME_0000868601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000868601-mRNA-1"/>
        <property type="gene ID" value="DME_0000868601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN52628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000868601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20538" checksum="F6B41D9153B8E09F" modified="2015-12-09" version="1">MMNCGDQFFHELQVLCRPGVVERFLPEFPEVCTKVRDTFAGLWGLEGNNKETRDIIADAVTNPHLYVLKQQLEGGAGNYYGSEIAEKLEIMDEEEKAAHILMERIYPESIKNYVIRPSEPVKLINVISELGIYGYLYGSGSFSTKDTIVLKNYNHGHILRSKGENVDKGGVAIGAAVIDSPFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULT9</accession>
    <name>A0A0N4ULT9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Laminin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2671</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000073">
        <property type="protein sequence ID" value="VDN52698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULT9"/>
    <dbReference type="WBParaSite" id="DME_0000878001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000878001-mRNA-1"/>
        <property type="gene ID" value="DME_0000878001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041081251" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN52698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000878001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7989" checksum="7D72235A07F87CCE" modified="2015-12-09" version="1">MSTARVVVLTFLFLSSVDAADYNPIVDCFKLVGNDNKKRPSIPPNACHDTDLGLCYELFKLDQGTIQNNLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4ULW8</accession>
    <name>A0A0N4ULW8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS2690</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000074">
        <property type="protein sequence ID" value="VDN52717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4ULW8"/>
    <dbReference type="STRING" id="318479.A0A0N4ULW8"/>
    <dbReference type="WBParaSite" id="DME_0000881401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000881401-mRNA-1"/>
        <property type="gene ID" value="DME_0000881401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000054">
        <property type="entry name" value="Cysteine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF5">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN52717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000881401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15546" checksum="148CC4DC3B529A8E" modified="2015-12-09" version="1">MNELDCIILRKMELLDHILEIIQKMPNCPGCGKPVILIILLSFNMSNIIFCFLEKIRFKIYRSIAERVTSIGKDWHRSCLRCENIHCRRTLIAGGHSEHQGKPYCNQCYGALFGPKGYGHGGSESHTFHNGLTGRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UM05</accession>
    <name>A0A0N4UM05_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DME_LOCUS2714</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000076">
        <property type="protein sequence ID" value="VDN52741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UM05"/>
    <dbReference type="STRING" id="318479.A0A0N4UM05"/>
    <dbReference type="WBParaSite" id="DME_0000885401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000885401-mRNA-1"/>
        <property type="gene ID" value="DME_0000885401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN52741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000885401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16923" checksum="16A22EEFEE085F92" modified="2015-12-09" version="1">MNIIVQFLILNHFLGTKYTLWGIGVLNDLLQGHKWTESGHFPRVTFCDVVIRELGNINRKTVQCVLMINMFNEKIFIAIWFWLLIIGTLTLINLIYWSVISFVPQFSRDFIGHSLVSAFSNKIKQQTKSFLLINVIPNPFSSLLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN01</accession>
    <name>A0A0N4UN01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-Sec23_Sec24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS2998</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000095">
        <property type="protein sequence ID" value="VDN53025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN01"/>
    <dbReference type="STRING" id="318479.A0A0N4UN01"/>
    <dbReference type="WBParaSite" id="DME_0000926101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000926101-mRNA-1"/>
        <property type="gene ID" value="DME_0000926101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000926101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12652" checksum="A1BEA0BDF7BD4997" modified="2015-12-09" version="1">MRSSLYIAPATSDILKHSQIPFVVAISPFAPLHPNEYRLPVIDCGEIGPIRCHRCKAYMCPFMEFQDGGRRFRCSFCLTSTEGRLNILIVFLICDKYTVISISKQARHKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN72</accession>
    <name>A0A0N4UN72_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3062</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000101">
        <property type="protein sequence ID" value="VDN53089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN72"/>
    <dbReference type="STRING" id="318479.A0A0N4UN72"/>
    <dbReference type="WBParaSite" id="DME_0000934001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000934001-mRNA-1"/>
        <property type="gene ID" value="DME_0000934001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877602at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000934001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33844" checksum="1E386FDCA0077B46" modified="2015-12-09" version="1">MSHISVNLNGRSTSNETIDGTLQSECQNVPFSSSTKSESETLNLKRNFKENCSLHRISFNWRKKEKFDTSLLRAHQRSRSADGENIYSIKFSCTSPLLRGETQWLSKNAQANNSSINALKATKNFFKRLYNSATLPVRSNKPVISKALVDSSLNGPQFEIRNSSNVNNEEEEQRYCEYEVNQDSTTCITTDNESISSTIKDIADEPMNDSVFRKSFNSTCSSNFSADFHSWSEFFDHLRKEIANMRERDAQILADLRRVEIQLENVKNRAMCSSKSNYELDRRKPKLGDLVESMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UN87</accession>
    <name>A0A0N4UN87_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed DNA polymerase from mobile element jockey-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS10639</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001231">
        <property type="protein sequence ID" value="VDN60666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UN87"/>
    <dbReference type="STRING" id="318479.A0A0N4UN87"/>
    <dbReference type="WBParaSite" id="DME_0000935601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000935601-mRNA-1"/>
        <property type="gene ID" value="DME_0000935601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN60666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000935601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9997" checksum="591A1EC1F2A575D4" modified="2015-12-09" version="1">MVTREPPIAKTIHYWKNIWEKQKIHNISAKWLQDLRISHNLPDNQRPAVDIERLKNIKSWVSPCPNMKHDLLAKKANSIHEPLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNR3</accession>
    <name>A0A0N4UNR3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase alpha chain, mitochondrial</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Propanoyl-CoA:carbon dioxide ligase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DME_LOCUS3228</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01000115">
        <property type="protein sequence ID" value="VDN53255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNR3"/>
    <dbReference type="STRING" id="318479.A0A0N4UNR3"/>
    <dbReference type="WBParaSite" id="DME_0000956101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000956101-mRNA-1"/>
        <property type="gene ID" value="DME_0000956101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0092">Biotin</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="22">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="114"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="20">
        <location>
            <begin position="597"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDN53255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="DME_0000956101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="685" mass="76418" checksum="E7EA912770851BD8" modified="2016-06-08" version="2">MALLSEIACRVIKTCRAMGIKTVAVHSDVDSASLHVKLADEAVCVGTAPTSESYLRADRILQAVKDTGAQAVHPGYGFLSENTDFAAKLEETGAVFIGPNSKAILAMGDKIHSKRIATEARVNMIPGYDGEIDDEDQCVKVANDIGYPVMIKASAGGGGKGMRIAWNDKEARDGYRLSKQEAKSSFGDDRMLVEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAPSSFVDPDMRKRMGAQATQLAIAVGYDSAGTVEFLVDSKKNFYFLEMNTRLQVEHPITEAITGLDIVQQMLRVAYGHKLKITQNDIGIRGWAFECRVYAEDPYKGFGLPSVGRLTKYEEPHRNVKGVRCDSGIREGSEISIYYDPLICKLVTHGKDREQALNRMRDALDNYVIRGPTHNIPLLRDIVEEKQFRSGNITTKYLMETYPEGFGGAKLSKSEECHLTALAAALQAHKSARAQQFTNQSRQRATVYDSYSHKYEFVVEMPRHEDEPYHRANVQVTFPQNKSNFAQVMVDGEKVDIHGDMNLAQSVLHFTVNGKPMTSQIASKKPWQFTLIFKGSPFKMKIMPAFAQNMLQFMKEKPKLDLSTVVIAPMPGAIKSVSATAGMMVSEGQELCVMEAMKMQNSLLAGKTGKVKQVNCKPGDTVDEGFILIELDVRKEEIFEDFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UNT8</accession>
    <name>A0A0N4UNT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS3260</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000118">
        <property type="protein sequence ID" value="VDN53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UNT8"/>
    <dbReference type="STRING" id="318479.A0A0N4UNT8"/>
    <dbReference type="WBParaSite" id="DME_0000959301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000959301-mRNA-1"/>
        <property type="gene ID" value="DME_0000959301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000959301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33473" checksum="D93E55A2B888FA9F" modified="2015-12-09" version="1">MKLHRENIQKPCASSGIGLETARSLALHGAHIVMANRDFLESKKIRDQIVKDKADAAIDIIIVNLDSLNSVKGAAEEPLHALILNAGVFNPSAKKTLDGFETAFGVNYLSHFYLIQLLLEKLRQSAPARIVVVSSISHNHTGVKSEWPLEEKMKTLIPGRQFSEAFCSIYKHYAVSKLDLNLMAVKLSRDEKINNIYVYILHPGTMIGTGIARNFGFLWQLIAMLTKPFTKSLQQGAATTIFCAVSDDLRNNSGHFFQDCQVANQNSAQLLMSDEELQDLLWNKTMDIINEFERKLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPH0</accession>
    <name>A0A0N4UPH0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS10777</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001246">
        <property type="protein sequence ID" value="VDN60804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPH0"/>
    <dbReference type="WBParaSite" id="DME_0000985601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000985601-mRNA-1"/>
        <property type="gene ID" value="DME_0000985601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875115at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN60804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000985601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12059" checksum="743AA3BBE698E3A2" modified="2015-12-09" version="1">MTINRINLLLRPQPGYTHKIFIFGICILFGWMIVIIICANPMVSYFTLLTLLLLHRKFARGSVEIQMSTTWTFKKQVFPRLRAEPHTASAFRSWSENSLSHCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UPH8</accession>
    <name>A0A0N4UPH8_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 10">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS3446</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 10"/>
    <dbReference type="EMBL" id="UYYG01000134">
        <property type="protein sequence ID" value="VDN53473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UPH8"/>
    <dbReference type="STRING" id="318479.A0A0N4UPH8"/>
    <dbReference type="WBParaSite" id="DME_0000986501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000986501-mRNA-1"/>
        <property type="gene ID" value="DME_0000986501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN53473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000986501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48426" checksum="AC481274A8C94229" modified="2015-12-09" version="1">MGLRYYNKRFIAIDLDFVPFVSEVIANDLSHKAFNLIRKNIEANGVSDIVKYSSADAVVFMMEHRYYDKRFTAIDLDPYGSASSFLDSAVQALCDNGLLMVTCTDMAVLCGNTPEACYAKYNSIGLRHKCCHEFAIRVLLKTIDSCANLHGKYIEPLLSVSVDFYVRIFARIRIGAKVAKDSATKVAYVLACTGCHSLDIQPIVRKMINNGSIKYNPSVFHSNLLADQNKCLHCSHPVHIAGPIYSAPMHDTDFVQNLIKRLEQTPVDQRFQTHNRLFGILNVISEELIDVPLYYEHDQLMHIVKTAVPRLLDIRSAIINAGYRCSISHCNPRALKTDAPTTLLWDVARALAKKNNVTLDRFDENSPGRKILESSIKLRKIVTHTIDFKVHPNALAKSKIDGLLRFQDNKGKNWGPKQKAKSKQNNVQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQ79</accession>
    <name>A0A0N4UQ79_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000165">
        <property type="protein sequence ID" value="VDN53697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQ79"/>
    <dbReference type="STRING" id="318479.A0A0N4UQ79"/>
    <dbReference type="WBParaSite" id="DME_0001015401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001015401-mRNA-1"/>
        <property type="gene ID" value="DME_0001015401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875120at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001015401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9978" checksum="49B2DEF1A778C0B4" modified="2015-12-09" version="1">MSAITDSEFCAEARQRFTHTKALFEQLERSGEQLPSFYSPRPQRQAPPPLPPKPAFHHSPSSPLSQLSNGLILWLLHVEKKNILWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQL2</accession>
    <name>A0A0N4UQL2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS3796</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000188">
        <property type="protein sequence ID" value="VDN53823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQL2"/>
    <dbReference type="STRING" id="318479.A0A0N4UQL2"/>
    <dbReference type="WBParaSite" id="DME_0001030301-mRNA-1">
        <property type="protein sequence ID" value="DME_0001030301-mRNA-1"/>
        <property type="gene ID" value="DME_0001030301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2289278at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334">
        <property type="entry name" value="SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN53823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0001030301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="65390" checksum="60C25461C8725014" modified="2015-12-09" version="1">MFCRCFACQQAISINLIYRIHLKTVEKRIAFLNKSDSLIWDAMDIIDECITWGKRRVDPWNRVSCCQKPVILLVEFCQIQGPRPLHCYPSNSFPHLDLDNIAIWLMSSESVQGSTVLLYNQQTALYACIYHSILLDIRARGFQKVAHKNSGLEQGNGHNAHEMMIHDVYEHSLSFDLLFMRPICLALLSVSKPTSSLLKSFMNRCQEIFTPIIVCNRNLFKFHASALFDFCDAVASLSPNSSTSLNMTKSSTLTRIESLLVQARQLLPKIEIVLNTIGKKAGIDGCASHTMESLNEWLNAFGTPYSAPLLDINHLMPCVFNTFIKAINNSYELFTKIDKTRRNGSLYCGDRAVLILKNYCMSTPNSTNFEWLEGNDYSDRENTLRAVVDKLDQILYPVLSGGRLALCASDQRKPAAMDLLQKLIMLNITAVNDNAFWIGEGENIPSFCSIFGQSVSRLQSAHWSAEHVDAVFDMNGNRLRSKEYNGTLLSTLSDKRFDSFPSDRSIIAFVTALLTDFCSLVYLAKFKGAEQICEAVKLHKDDAAILVNLLTQLDFIKYNKLRDTVRESVKSDPRLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQM1</accession>
    <name>A0A0N4UQM1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS3807</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000190">
        <property type="protein sequence ID" value="VDN53834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQM1"/>
    <dbReference type="STRING" id="318479.A0A0N4UQM1"/>
    <dbReference type="WBParaSite" id="DME_0001031401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001031401-mRNA-1"/>
        <property type="gene ID" value="DME_0001031401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="175"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN53834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0001031401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39722" checksum="C6E14AE572EF7E6E" modified="2015-12-09" version="1">MRKILFSDQDLQVICENIRRLTDAVLNQDSISMIVSRQFISDLIECNIELGKTSPATARSIALDLLPVIQSRQISYEEQVVKLFMALADLHEKEGSFKDAANMLRAMPLENGQRSYSSEMKLNIYVRLADLAMRYGDGDEAETFINRASVVSNDLQNNKNVYIPFKIKFAEVLNYRQKFVEAARKYYDLATFENLERSDQLMALSNAIVCTIFAPPGAKRSRMLGMLFNNEKCKPIPSYSIVKNMYLGKIIQNDEMVDFEKSLTDNQRSMHGWAVMHRAFLEHNIIAISASFTNMPLIQLARLLGIDEVQVRSLIRFLAEDILLQMIIDNRLVATIDQISGFIHFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UQZ1</accession>
    <name>A0A0N4UQZ1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS3911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000216">
        <property type="protein sequence ID" value="VDN53938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UQZ1"/>
    <dbReference type="WBParaSite" id="DME_0001045701-mRNA-1">
        <property type="protein sequence ID" value="DME_0001045701-mRNA-1"/>
        <property type="gene ID" value="DME_0001045701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN53938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0001045701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8781" checksum="EE76473B67EFCEE5" modified="2015-12-09" version="1">MCSQARTIAQNLSRGIAVYSSGEVLAVPACNVKTLMDVASQAITVYTLSKHRVDIACLLEVLPRSSLVQTWLRAEILATSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4URC9</accession>
    <name>A0A0N4URC9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4029</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000253">
        <property type="protein sequence ID" value="VDN54056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4URC9"/>
    <dbReference type="STRING" id="318479.A0A0N4URC9"/>
    <dbReference type="WBParaSite" id="DME_0001060401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001060401-mRNA-1"/>
        <property type="gene ID" value="DME_0001060401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001060401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33396" checksum="795A0562123D7575" modified="2015-12-09" version="1">MLEFRTPFALPRGNVGTSTAHLLQMINECKLPSSAIKSLAFMHKRQRKYGSVNYKYEPNDNHNERKNNRCENEREKSRYAEFTDSKSDSGDSEDWERHEALNDDIAEQEHTIQNKYEEELEVTWEKGGPGLVWHLDTFTWKQIEEGTDSDWKWTDSWDVDYSLYDDENVSRNEFGWKPGDGLGVDSKRQPNSSWVDIMDSCIKYMAHYGSGLGYHGEKLQRLGLRRQTSHSIRTMYAITSASINFFLQLEISFLLTPIKAQRCRIPPKLSYILAHHKTLSPNSIVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US00</accession>
    <name>A0A0N4US00_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4230</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000438">
        <property type="protein sequence ID" value="VDN54257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US00"/>
    <dbReference type="STRING" id="318479.A0A0N4US00"/>
    <dbReference type="WBParaSite" id="DME_0001083201-mRNA-1">
        <property type="protein sequence ID" value="DME_0001083201-mRNA-1"/>
        <property type="gene ID" value="DME_0001083201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860166at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033229992" evidence="2">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="151"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0001083201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29143" checksum="C4F2391C0C0E32B0" modified="2015-12-09" version="1">MLALLLLCFSADFSLQQQQLPPPPPPPPPPGPLPPPPQPQPQPQPQQQPPPQPALPPLPPVQQQPDYENLLRDTIADCLSDYQCRVFEHCVVGKCIRDTRACPGGTCPAGMVCVAGRCLPDPLIATTESILGRLKEECPSPWTFSQQFNACYYVGRGSYNFFTASAECRRLGGTVASIGSSEEMTYVNGLVGSGAYWIGYHHTRFSSNWEDGSPVGFTNYRRGQPDGCCGGAGCTLVNYRSNLGEWDDAGCHVIWRTPTYAVCKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4US32</accession>
    <name>A0A0N4US32_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDNF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS4258</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000504">
        <property type="protein sequence ID" value="VDN54285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4US32"/>
    <dbReference type="WBParaSite" id="DME_0001086401-mRNA-1">
        <property type="protein sequence ID" value="DME_0001086401-mRNA-1"/>
        <property type="gene ID" value="DME_0001086401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041121267" evidence="1">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN54285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0001086401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16875" checksum="EF36A2A0A45A5135" modified="2015-12-09" version="1">MLYHFYWICLIYGAKGAVDVAIVDCNKGVPDGGGMIHQRPTVHPQLCARIDIPACIAIFDIKGNPEDENKVGAHCEAFTLDMCGNPSLTDLSLRRYQQKCSLWSECFHYLMVTTLGTESRKRLCDRETCLLSYFQQYNANVKEQTWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q306</accession>
    <name>A0A158Q306_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5747</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q306"/>
    <dbReference type="WBParaSite" id="DME_0000138701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000138701-mRNA-1"/>
        <property type="gene ID" value="DME_0000138701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372137at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
        <property type="entry name" value="FRRS1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041121030" evidence="1">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000138701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25501" checksum="BE780D292E63B496" modified="2016-06-08" version="1">MFWRFLLPFVYLWCLPAISMDKSKCGHSALCMFQPAGCNPKLDCTLGLILSINDNDTILQIQSVAQKLFPPVALQYIAIGFSKDKIMGDDMVIECILSDQIEDSGPEVFLSHNIGKSNDRIYLDQSERSLYFHNVSSIVIDGRLYCNYSIDIKPQIREKKDRAWDLNDNFYIFGVTGSAQPDDYTMNIHHINITYPKLINFIMHVEPIVLLFRQLFSHKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q314</accession>
    <name>A0A158Q314_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS5787</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q314"/>
    <dbReference type="STRING" id="318479.A0A158Q314"/>
    <dbReference type="WBParaSite" id="DME_0000142701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000142701-mRNA-1"/>
        <property type="gene ID" value="DME_0000142701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9445857at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029512">
        <property type="entry name" value="CCDC154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN55814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000142701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="63375" checksum="A2191D3074370245" modified="2016-06-08" version="1">MSRKRSGPRDTAKDIILGLDPSGESPRQPREGIAKITDANCFSRKKAPVNAVQPTLIKQTDSNVLQNLQNQLSLLQQQYNELLRKEMEARKILEANQNALNQKLSSIDINDLMKEIEGLRRGITMNDGKANRNVDNKLNDLCQQINDIKRMITDEIDERSKMIQLQKDDIIQKILCEEEFKNFEKQNFERKIKQGLEKMNEEIQLLRDAKNIKSGVNQNINDESELNRKIMKNSSDVQEWCKRQINEFKEELARKLAKDLDKKLEILSNELRNMSEDHEREKAECRNKLNGINEALANLESQIEDGDNKINKLTLTSSQSRKNDENRLLMKIDEIEELINHYTNDLKKVIGDIHNGKQNIKFPSFDFDILRNEMDSIAADRNKMSMAGLLKLEEKISELQNGFHRDKLELQHQFEILAINMDGMEGITNHLHKLQSIHNEMNKAQQMLRDRVEKQIPHDLNELSAKTDNVKHQLNTRIDREEEERLFAIKKLQEKIETDLGLQKTENKIGIDENMKIAVRKLAESVVTAKDFLNNKITVEVQQVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q389</accession>
    <name>A0A158Q389_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6239</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001155">
        <property type="protein sequence ID" value="VDN56266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q389"/>
    <dbReference type="STRING" id="318479.A0A158Q389"/>
    <dbReference type="WBParaSite" id="DME_0000187901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000187901-mRNA-1"/>
        <property type="gene ID" value="DME_0000187901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000187901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39659" checksum="F6269BB2385CB7AB" modified="2016-06-08" version="1">MSRSECLDDTQMMLTTSHLDNIIQHYIFPIQFILGVVGNSMNLLVLLSKGMRSETNYLLSAMAFADLSLLFCMLPHSIASFEIAYRSYSFRYIYYISKRQINAMANLFSAAAAWLVLAVSIERFIGIRSPMQARLQWRDGKIKILIISIFVGAFIVTFYHHIAYKYSIHILCNDTQLRGNVIPIEYNWTGDKFFGKFVTNYVKFSKYLQLFTVILVPIMAVAFLNVSLICFVKNRDIHHHNYSNKWSKWSLADTGMVQRQERRVTTTVLAIVTCFTITHAPSLIPFVWETLGISISNPRPFLATVSIVNSLVITGKVLNFVLFCSSSVYFRRRLNAILLSRIVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3M4</accession>
    <name>A0A158Q3M4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS7052</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3M4"/>
    <dbReference type="STRING" id="318479.A0A158Q3M4"/>
    <dbReference type="WBParaSite" id="DME_0000269201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000269201-mRNA-1"/>
        <property type="gene ID" value="DME_0000269201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77368at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03406">
        <property type="entry name" value="SPFH_like_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000009">
        <property type="entry name" value="Erlin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033294">
        <property type="entry name" value="Erlin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351:SF3">
        <property type="entry name" value="ERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351">
        <property type="entry name" value="ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250186" evidence="9">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="10">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN57079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000269201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36138" checksum="BE34D517740D4408" modified="2016-06-08" version="1">MVPNWSFAFVAAFLLLLIACSIHRIDEGHVGVYFRGGALLSSVSEPGYHLMFPFLTTFRSVQVTLQTDETRNVPCGTSGGVMIFFDRIEIVNILSPSSVYNIVKNYTVDYDKPLIFNKVHHEVNQFCSRHTLQEVYIDLFDQIDDNLKRALQMDLNIMAPGLAVQAVRVTKPKIPESIRQNYERMEAEKTKLLVAIEHQRVVEKEAETERKKAVIEAEKAAQVAAIQFQQAIDKKEAQKKIAQLEDESHKASQLAKADAEFYSKMKEAEGNRLLLTEEYLTLKKIEAVAANNKIYYGSSIPNAFLDLNMWKTEQKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q3U0</accession>
    <name>A0A158Q3U0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS7325</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q3U0"/>
    <dbReference type="STRING" id="318479.A0A158Q3U0"/>
    <dbReference type="WBParaSite" id="DME_0000316601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000316601-mRNA-1"/>
        <property type="gene ID" value="DME_0000316601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN57352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000316601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40125" checksum="EC9C48E433A6971A" modified="2016-06-08" version="1">MKHLVFAYYYINALFKRKLYFEILKLKLGNLIYRFFHFPSFLSDLDSAMIKQLFKLEACILILIGKTYLMTQNRHNAQLYLRSAFTKEPTAIEALDIIKKYNLIPKRFKDCILVHIATLVQLHKCDQLFMLAHQLVDSEPDSEISWYTVGCYYYAANQPHKCTIMNPLFGEGWIAFGHVLTAESEHEQAMNCYLRVCPKFYLDFKMFEYFLKDAADVAGDSALVLHEQGCIYYMKKDWITLRLAYNETNENISLVDLISRPLSDFWEPLINNLGHVKRKLGYFSEAVKFHQKSLLMCPRRSGALSALAFSLACEGELELAIQYFHEALVVNPENQVLLNLLTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4H0</accession>
    <name>A0A158Q4H0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS8711</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001171">
        <property type="protein sequence ID" value="VDN58738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4H0"/>
    <dbReference type="WBParaSite" id="DME_0000482801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000482801-mRNA-1"/>
        <property type="gene ID" value="DME_0000482801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835902at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN58738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000482801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19816" checksum="81E64A955CB04D7C" modified="2016-06-08" version="1">MNVQQQIVDTFYLKTKDYFLFDIFVLNPNDIVAGQRYSIDIFMDQTDQYDYLIQRCSYNNKYYFIDDNSCLIVNEYFIQKWETDHYYEYPGSIKRTIIHFIAPEELSYLHCQIKHIQCCGCAERACEFNILPLLENYHYNNINIEMIGNSHPFIYNDLSIFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4J6</accession>
    <name>A0A158Q4J6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8833</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001173">
        <property type="protein sequence ID" value="VDN58860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4J6"/>
    <dbReference type="STRING" id="318479.A0A158Q4J6"/>
    <dbReference type="WBParaSite" id="DME_0000503401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000503401-mRNA-1"/>
        <property type="gene ID" value="DME_0000503401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19764">
        <property type="entry name" value="Bbox2_TRIM9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000503401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33164" checksum="529C5E4EE7C18BBD" modified="2016-06-08" version="1">MEEELKCPHCKEFATGDHHPVLLSCAHSYCRQCAVQSQQPACHGVPSGSSATLPPTVYSHLQRVTPLSPPCSSSGASDTISVCISDQDQESDKLSVVSEADSGVVICGRNSRPSSLIGSALSQQTHLHRLPSILTPSTSECTITCKACQKPTYLPDEQTILNMQKNVALCNLINRYRSSQISAAKDKTASETINCQLCDTDKPAVASVFCEQCDIFYCQLCQSTLHPSRGPLATHKLVHPSAKKLSTPSLVLVKESKCTNHPTEVLTMYCVICRTAICCICLQEIRHSNHDVQSIEKMCKCQKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4N1</accession>
    <name>A0A158Q4N1_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS9048</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001175">
        <property type="protein sequence ID" value="VDN59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4N1"/>
    <dbReference type="STRING" id="318479.A0A158Q4N1"/>
    <dbReference type="WBParaSite" id="DME_0000524901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000524901-mRNA-1"/>
        <property type="gene ID" value="DME_0000524901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="4"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="340"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN59075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000524901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="656" mass="75440" checksum="FEF9B4391268319C" modified="2016-06-08" version="1">MAESVRVIVRCRPLNSRESALKSQICVTMDESCGRVTLSTTNKGALPKEFTFDGVYYMDASTEQIYNDIVYTLVESVIEGYNGTVFAYGQTGSGKTFTMQGDDNIISQKGIILRVFEHIFEAISTTDNTKFLVHVSYLEIYNEEIRDLLGLEKGIKLEIKEHPERGIYVAGLSMHVCHDFQACQSLMNKGFENRHVGSTLMNKDSSRSHSIFTIYVEAMLKNGTIRTGKINLVDLAGSERQSKTGATGERFKEATKINLSLSALGNVISALVDGKSKHIPYRDSKLTRLLQDSLGGNMKTIMVACISPSDNNYDETLSTLRYANRAKNIKNKPKINEDPKDALLREYQEEIERLKAMINSNTTLEQFDQRKEHDHLKTQYEIAINELRSKYHMEQQSKAKLQEEFLLLKEQYENSLEAIDREKPIDAIEAQKRLERLEQQFVGGEQTSNLALKEKRLLKKEEAEKKMQKLAAALNVDSDDPLLHVYSSTQEKLEAITIQYNKAKRQIKLLDSEIKDLHGEFELDRLDYLETIRKQDQLIKLLQQIIDKIHPLLRKEMNYYNLEKIKKDAKWDEDQGKWILPDLTILKSITLPNAKIVTTTEQIEPYCVSNEFNTSKLKMRLEKSEEENIANNYFKQFNRNEFINKYKADRSKDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4R4</accession>
    <name>A0A158Q4R4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS571</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4R4"/>
    <dbReference type="STRING" id="318479.A0A158Q4R4"/>
    <dbReference type="WBParaSite" id="DME_0000546501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000546501-mRNA-1"/>
        <property type="gene ID" value="DME_0000546501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856676at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033250198" description="Abnormal cell migration protein 18-like fibronectin type I domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000546501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35883" checksum="EA4E8F76BD7FB20D" modified="2016-06-08" version="1">MFMKILTFFAIFIGKCDQRSMILTNWFGNGVRNVRYMTVANNFIDTKGNYVANKSNPRQERSKTIYDCVDIMGTIRKHGEQYERPNGRFKYRCNNGECRPINWSITTWLVLIMLFWARSRQRNIHKIWISACIGSERNGKALIKIGNTLDKDGFWYKCAYFPENQTGIYTEGKLLEAICAVCIKNNHVFKEGERYAANHLHYECKAGTPLITGCYTNENRKMQVGEDIIEKNMVYRCYRLNSLIHYEEYACGFRGTPSCKPEPIQSEPNNLINFNRSFNSFSIAQLTQRTGEDKIVAGSSSISLVPVISAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q4S0</accession>
    <name>A0A158Q4S0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS9270</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001179">
        <property type="protein sequence ID" value="VDN59297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q4S0"/>
    <dbReference type="STRING" id="318479.A0A158Q4S0"/>
    <dbReference type="WBParaSite" id="DME_0000552901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000552901-mRNA-1"/>
        <property type="gene ID" value="DME_0000552901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="293"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN59297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000552901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="712" mass="82995" checksum="DF65DAB548595BF5" modified="2016-06-08" version="1">MLRRRIVLTGYPLQNNLMEYYCMVDFVRPFYLGTKKEFAIMFEKPITNGLCIDATQNDVRIARQRTHVLVEMLKGFVQRRTHHLLKKILPPSFQFIILLRKSLIQRLLYRSFLQYALSTITTFRLSVFNPLKAFAVCSKIWAHPDILYVVLRRQKEAYIQSREKTGVADNSQCKEWTESLSENYTYTEWLHDSSLDNANKMNEIKSSEKIKSNSNSRTERNFRDSSRSHSPIQNCENMLDNNFSKHKETYVDRLLLGEFDLDNKVNYDWAYSIMDNYVMGNIENGYKIVLSLAIIQQAVLMGEKILLFSQSLLSLNLIEQYIKKDSTLTALNGGQPWKRFINYFRFDGSTSATERERLINLFNENSNVNLFLISTKAGSLGINLVSANRVIIYDVSWNPCHDAQAICRIYRYGQTRRTYIYRLIIDNSMERAIFNRQLGKFGLLKRVVDDRQTDIDVTKEELDQLLVYNEALDINNTEFDVNSWHIEDELLKVVASKYSKFFSQMPILHESLLFEREEGLSMEEKIEAQLLYEKEKCLYDRVDHNLDLLRSSGSQVFTSSSQGNFVDRTYSSTAHLPDFGPYSLMQPTPTPTPLEMVLQKILPFNPERTDFIRRRKEKRIEVKNAANMLAGGKVTQITVDRELTLPSITESGKMHKLMPDERLFLVTLPTGVFLRSLNGEIYDARNSIYDPNRSKKLLFQFHIFLSIEQFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q504</accession>
    <name>A0A158Q504_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS9460</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001182">
        <property type="protein sequence ID" value="VDN59487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q504"/>
    <dbReference type="STRING" id="318479.A0A158Q504"/>
    <dbReference type="WBParaSite" id="DME_0000616401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000616401-mRNA-1"/>
        <property type="gene ID" value="DME_0000616401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN59487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000616401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10407" checksum="A8ADE2C4B7068BC3" modified="2016-06-08" version="1">MVGDYFFTCDSIWLADQMDASGNVYIYYFDQPSSVNPWPKWTGVMHGYEIEYVFGAPVYNFSAGYTRAEKLFSEKIVEYWKSFAIYGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q593</accession>
    <name>A0A158Q593_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cnd3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS1439</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000021">
        <property type="protein sequence ID" value="VDN51466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q593"/>
    <dbReference type="STRING" id="318479.A0A158Q593"/>
    <dbReference type="WBParaSite" id="DME_0000682501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000682501-mRNA-1"/>
        <property type="gene ID" value="DME_0000682501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="2">
        <location>
            <begin position="335"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN51466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000682501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="76103" checksum="DFD7BA65EBD2E1B8" modified="2016-06-08" version="1">MGTVGITRRSAVTQGGQVTNLNAKSVDGGVDYFLSSTRFAIEMVCAKQTEREKRKNCLKMIANLALELQYNGMPQLLFSLIGFCSEIDVALADRNASVRNAAVLKLINLDLMSLSVTQRMDIVRLLVFNKDSGCKMLNTRLFDKWLTMANHADDSASKKEPQKLSPLKLLYFLEPVEEEEVSRRFMNQLLTHCRELMLLTKVHLYKFVKVIIGQGDCFVVCSQNYKELLNKNSLSPFERANAIFFWQCLLEFCQLNSCTEADWFECKYLLLPTLRTFCEFIHKFLPLEALNNISDFISYIMHRSINPNATVLSANNTISLVNDYNTLETDPNEIEKGLLCQNLKCRMLALEAMGLLAVHDRRIAFEKTILIKDALKLDEGLKVTLLDVLCNISLVHGYKNVSNWFIGNISFSHPENELIKVFVDNSENRDPEVRFTACLSLCKLMIHEVNLSWSKIFAELMLKAFQLCKKEDFKIRNCIITFLSIFAETSSDHQAMLKHSAQLVLCEKIVELILHDPDDIFMGVYCKMASEMTLFHDLRKKKERNIWIALAKRLRDRIKQLKSAKKIILPNKGTDELVVLTSNLSLNTSRINLKENVKSSQKVKKIPLLSNSQNKKISSKDNCLRVINLLQQTDMNFDENAVVAADTPKQRPFLPRNAKISSLPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q5Y9</accession>
    <name>A0A158Q5Y9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS2518</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000065">
        <property type="protein sequence ID" value="VDN52545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q5Y9"/>
    <dbReference type="STRING" id="318479.A0A158Q5Y9"/>
    <dbReference type="WBParaSite" id="DME_0000860301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000860301-mRNA-1"/>
        <property type="gene ID" value="DME_0000860301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000551">
        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="255"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="349"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="446"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN52545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000860301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="591" mass="66955" checksum="31581A1F08056D5A" modified="2016-06-08" version="1">MHTAVDNSFYKIKKFIQKTYTSLYKLIGTKDAPLKMPLKITYAQNILSVPSKQLWVSDRRLHVLRPFYSLRITPTLPHDSGLYQCRLETDPLFALAMSTGSILLIVMGKHCIVQDTIFKPIKYEKERRIYHKLYVSGMAMGYTTANDLKITIVRPLSPSKPEILSVTERSVTLSWKISSSQAHKPILQQAVLIRRLSDKDERIMTLQGNNTTAVISGLMPITQYAFSIRLQNAAGISEFSPFTLQTTLGEALSSAPKIRSIQNTSDGCIKALWEQPVDPNNSLIGYRIMIHRMSTKTMREWYIKSDEHVICGLPYNSKYQISVEADNGYGYSPSALDTFYTDESIPDGPPENIKAQAFSSSTVEVSWNPPKRPNGKIIAYQIYIRLEKEEQPLRLKIHGITSINKISYNISDLQPYKTYALMVSAFTKKGEGDRSNEIFVTTDHQTPSPPEISNITFNCKDTVTVYWSDQSEHIHFYYLLLEGNSQHFYNTTSKMANLQRLTKHLRYSVKVSSVIRSILNNSMPIFSQWSKDEIFLIDDQCKLKSSLCSSPLCESIILPSVPSVSLPVTICAFIVAIILSLLVVLNVEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q696</accession>
    <name>A0A158Q696_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS10662</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="UYYG01001233">
        <property type="protein sequence ID" value="VDN60689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q696"/>
    <dbReference type="STRING" id="318479.A0A158Q696"/>
    <dbReference type="WBParaSite" id="DME_0000944201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000944201-mRNA-1"/>
        <property type="gene ID" value="DME_0000944201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20338">
        <property type="entry name" value="BRcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16629">
        <property type="entry name" value="RING-HC_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000137">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="100"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN60689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000944201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="863" mass="95409" checksum="85730C018703D763" modified="2016-06-08" version="1">MNCSIIDIKSLNVGEYCGQVEVNDKINCSTLQTSRSLSNDDSHSVDSVVIENSDLDSGCRVDGDFNEPRIHSNDDGVAAQPTVRRPAQFSQNNTSNSAKKLRECPLCFIRQSEKNFPQLACCNHRSCKSCLVQYLQVEIMESRVQITCPECSEFLHPTDIYSLMVQHPDLIEKYENFSLRRVLMTDPDTRWCPAPDCTYAVIATSCAACPELHCEKCGTLFCYHCKGPWHASQTCDEARRERGRKLRNTVPRRHRQSFGNQLKRGDIKPCPRCRTYIVKLDDGSCNHMACAMCSAQFCWLCLREINDLHYLRNTFSPTGCTFWGKKPWTRKKKLLWQVGTLIGAPVGIALIAGLAIPGIIFGVPVFVGRKVNQRFAQHSRVRRRLLTAGSVIGSLVVSPVLAVMAVGVGVPIMLAYVYGVVPLSLCRNGGCGVGAASSSSDRNELDDEEIWHDLNGNQEKSRLLNEIERFDDTSLITGVSINSGLSSQQTHTTVRVKAELCRRRPSIESGVLSFGEKCNYEEASTKAMAGSQFCDDKSVHTICSGQEAISYCEEIASTVALAGSVIDAKSLSDSASGRHTNQICCKDRDVSPTSHQALFACDPQHKSEEDRSNYSHCNQDSLPTHLEDDANSSYEIGKLHGRAASNTSSYSSGRRNIRKVSHSPSDQISNLNVVNNLEKGEIELFLMNEDTAIHLTNESSYSRPSSSAAINKTSYSSTGGISSQGAISNLRAAHFSDAIDQSNADRFHIRALFDAMKQIVSDDVANESDDEISSENPISNSFRSMLLRPYTKNILTADNENGEGSLKGVRTITSLSSSNGSDKYRAISRDKRVSSSLSRSTASSSDRRRSKWRIFSIFSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6F9</accession>
    <name>A0A158Q6F9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SF4 helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS3533</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000145">
        <property type="protein sequence ID" value="VDN53560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6F9"/>
    <dbReference type="STRING" id="318479.A0A158Q6F9"/>
    <dbReference type="WBParaSite" id="DME_0000999301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000999301-mRNA-1"/>
        <property type="gene ID" value="DME_0000999301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="246"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN53560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000999301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="60102" checksum="D74C0068756015EE" modified="2016-06-08" version="1">MSDTTIRLLWTDSVDFRDVRDLTEQSEYLTLRKQLGVDHVSLDTLSRYHVRGHMDSFDRPALLYPRYRGPSSRARIPAGLKVIRKFGDRLEKENYPQPDDNGKPLFSGIFGFNLVTASDRRVIITTNERDALAVFEATNGLLSLALPMGERLDTSILPYFEDFDTIYIWFPYIHDHYAKDYAAYLNANRCFIVNRKERPIELLRNELRREVNKAIREEAVLLRSKGFRSMIDVRSDLKSEIINSRSKLFGLAQWKRFDVLNKYMIGFRPSEMTVLTGGTGYGKTTFLCEYSLDLLSQGVRTLFCSFEMPDEKILKWMLVQYAAVPLYRVEHHPSVEMWLDRFERTKGDLVIMKIDEFRDKNITQISNAIRSQVIASGIQHLVIDNLQFLIGLATMNVEKTNALEKYNQQDRFVGLLRGIATDYGPHVTIVVHPRKTDSDTDLDIQHFGGSARVTQEADNVFAIQRRRDEDRKYRKFLYILKNRYGQKKVESDLIEMVFQPSTYTHTLIDLSLTGAGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158Q6K1</accession>
    <name>A0A158Q6K1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Degenerin unc-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DME_LOCUS3822</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000193">
        <property type="protein sequence ID" value="VDN53849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158Q6K1"/>
    <dbReference type="STRING" id="318479.A0A158Q6K1"/>
    <dbReference type="WBParaSite" id="DME_0001032901-mRNA-1">
        <property type="protein sequence ID" value="DME_0001032901-mRNA-1"/>
        <property type="gene ID" value="DME_0001032901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF242">
        <property type="entry name" value="DEGENERIN UNC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDN53849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="DME_0001032901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="704" mass="81398" checksum="4E726B99F8BA51B7" modified="2016-06-08" version="1">MGGHQCKQNGVYYDDRCVNKKVSTKIRACRTLPKLLQMFSSRSWKPSEDRYNSASALFKDFCNRTSSHGIPLIGSPSFFNRAVWTLITLLCFILFLYQTYWTLSEFFQYRTIIEMQLKFEPAPFPAATVCNLNAFKNSKLRQYREISEGLDVWEEQINRIKEPFDERLVIRKRRQVSYAPIFVRCNCIEQEDHCVPQRNPLYVNATVCICFEDLNTGNIWPCYPTMVWAEKKCYHCSMSNTCDDPDRLNASSIQTSSNAWKCLCQSVSHSCVVMPKEEIRWWNPNKYSVIMQSSTSSPELVEKFGMKDRKDPIAITARAKETLIFMIAALPKEERKNLSYTLDEFVLRCSFNSEDCNNERDFKLHMDPEYGNCYTFNFNDSVELKNSRAGPMYGLRLLLNVNQSDYLPTTEAAGVRLVVHEQHQEPFPDTFGYSAPTGFVSSFGLKTKILHRLDAPYGSCSDSFRPEKYIYEEHYSPEGCHRNCFQHNVIEKCGCGDPRFPLPSDDQHSCDIRNASERSCLRTFTALTSGFHHLQEKCNCVQPCTENVFETAYSASAWPASNFKIGVACPAFDDITNDSIKCTEFYRLNTAYIEIYYEQLNFEMLRETAGYSIVNLFSDFGGNIGLWIGFSIITMMEIVEFICELLYYVVYKRPVRNAKKKRRKEENQLMKPQIYRQADVSSSSSKIERSATTDTILDYDDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PFV6</accession>
    <name>A0A3P7PFV6_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS2933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000090">
        <property type="protein sequence ID" value="VDN52960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PFV6"/>
    <dbReference type="STRING" id="318479.A0A3P7PFV6"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000005">
        <property type="entry name" value="TatD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN52960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="273" mass="30769" checksum="08BAFF7DD0782D5F" modified="2019-02-13" version="1">MFENDFGDVVVRAKQAGLQKIIVTGTNLEISEKAKNLASLHPGFLYFTAGIHPHDAKTFDENSYYALEQLCADQRCVAVGECGLDYNRNFSTPDVQKVVFEKQVKLACSIKKPLFVHQRDAHVDVLNILAKFKETLPPTVIHCFTGTSNEAVDCINNGYYIGLTGFLWKDRSENGVKNALMNRKIPLDRLVLETDSPFMYPKINDKNIPKNIKDRISSHSRKLHQFSSFNRNEPSALAAICDLVAAYLDEDPIKVAQITSENARNIFFLNKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7PHG2</accession>
    <name>A0A3P7PHG2_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000567">
        <property type="protein sequence ID" value="VDN54305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7PHG2"/>
    <dbReference type="STRING" id="318479.A0A3P7PHG2"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000005">
        <property type="entry name" value="Pancreatic trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF373">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="206" mass="23678" checksum="D75E2FCE425AAC57" modified="2019-02-13" version="1">MLPEDRGPCFGEIVRWRYNSEISSCVTFIYTGCDHNANYFTSEEACERACGLFRNQDVCSMRVNKGSCNLGITKWYFNKNLGECHVFMYSGCGGNGNRFSSKAECQHLCSLETKISEDEDICKFERDSGPCIDAVTQWYFDKEDEQCKQFTYGGCRGNQNRFNSKDSCEKKCAQKRKNRTLIDAQNSVLKSTGSAFFIRFFCFIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q0C9</accession>
    <name>A0A3P7Q0C9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS10823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001252">
        <property type="protein sequence ID" value="VDN60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q0C9"/>
    <dbReference type="STRING" id="318479.A0A3P7Q0C9"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="121" mass="14037" checksum="CE386064828EC653" modified="2019-02-13" version="1">MFASQTVLRSFTKKPIKWRQKFSVEIDASQFHPSELSVNIRENELIVEGKHEERNDENGTIQRHFIRKYEIPSDVQMDTIESNLSDHGVLSINARKVPSDIRRIPIKPSPPSNDNQKLDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Q3A3</accession>
    <name>A0A3P7Q3A3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS6571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Q3A3"/>
    <dbReference type="OrthoDB" id="5860564at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN56598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15788" checksum="4EEB831FBCCE68F0" modified="2019-02-13" version="1">MLIFAPSNNKNQNPIIGQAIFCYDCHSDHGTCNDGKCDGIVCIKMETSNKDNERRTVQKGCGDDIEENGCQQSGFGSKWTSRCVCDRSWCNGDEQLAASGLESSSGTVNTSLPKTQLALILFIFVFLAASCLLLIFNTICVQCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7S7I9</accession>
    <name>A0A3P7S7I9_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyglutamine-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyglutamine tract-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS609</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01000005">
        <property type="protein sequence ID" value="VDN50636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7S7I9"/>
    <dbReference type="STRING" id="318479.A0A3P7S7I9"/>
    <dbReference type="OrthoDB" id="42462at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF3">
        <property type="entry name" value="POLYGLUTAMINE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN50636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="204" mass="23275" checksum="3E79D4004A1ED07C" modified="2019-02-13" version="1">MMSNSDLNEEIIAESYDSELTTGLQKKNEAVGSFAVGCPNKWNPYHYCVQFCYDYWKDGLSEKKLPQKYTEQRLKALKKYPLPSGWKEVYDPGCARHYYWCPRTDEVSWLPPRHPLAVIGDAAPKVSKGLFVLKKIFYQINSTQNIHFSSLDFLITVQDIGTWSSGLHAHDKTGADVTASGPLFQQRPYPAPGAVLRKQQQQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7SJQ5</accession>
    <name>A0A3P7SJQ5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS1602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000026">
        <property type="protein sequence ID" value="VDN51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7SJQ5"/>
    <dbReference type="STRING" id="318479.A0A3P7SJQ5"/>
    <dbReference type="OrthoDB" id="10058001at2759"/>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF14">
        <property type="entry name" value="PROTEIN CBG16414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <sequence length="95" mass="10429" checksum="1FC09A6C1506507D" modified="2019-02-13" version="1">MISLDRHGLRTVQVDKLKPGPFGFYIATGLINNRQGIFISRISLPSLTSVLSAGDEIVYIENELVKGRTLEYVQSLLADKTNIKIVLSPANCPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0R2</accession>
    <name>A0A0N4U0R2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS4510</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0R2"/>
    <dbReference type="STRING" id="318479.A0A0N4U0R2"/>
    <dbReference type="WBParaSite" id="DME_0000015001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000015001-mRNA-1"/>
        <property type="gene ID" value="DME_0000015001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF237">
        <property type="entry name" value="CUTICLE COLLAGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN54537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000015001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="29982" checksum="C93903BDB21E7BD3" modified="2015-12-09" version="1">MESDGRIKAYKFVAYSAVTFSIVAVLSVVVTLPMVYNYVGHVRRQMHHEINFCKGSAQDIYTELTYLKNNPMDNKTNRTARQSGYAPNGPEINPSVNLQCEDCCLPGPPGPPGVPGRPGKHGKPGAPGTPGRPGKPPTAPCEAATPPPCKPCPQGPPGPPGPPGAPGDPGEAGTPGRPGIDASPGSPGPRGPPGPPGEPGPPGPPGEPGTPAQSEPPTPGEPGEPGDPGPPGPPGPPGAPGADGTPGPAGPKGAPGPDGPPGLDGQPGPPGPPGPPGAPGEKGICPKYCAIDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U0S9</accession>
    <name>A0A0N4U0S9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS4530</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U0S9"/>
    <dbReference type="STRING" id="318479.A0A0N4U0S9"/>
    <dbReference type="WBParaSite" id="DME_0000017001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000017001-mRNA-1"/>
        <property type="gene ID" value="DME_0000017001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033720790" evidence="2">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN54557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000017001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="49726" checksum="45A5B68748BD10C4" modified="2015-12-09" version="1">MLTLFRLISFISLILHTAAVNDGRISENPLSTERGSGTNMGSGAVWNGGNEISPQKPINTASSNFQYFCGYCIMNLTQSSDCNPGNFDFNNVTTTISNQGLNLEGDNFKCEQCQSEQQSNFQSFGGRNFGYGQALIFNYRGFDCISCDSNRDNQCLFKCQGCHFERRSSSGIKIDRGGWYPSNQGPWNPNDQGRSGWYPNNRGGNWWYPGGPGGSGGYPGGQSYPSGQGYPGGQQYPGGQGYPSSQGYPGGQGYPGVQGYPRSQGYPAGQGYPGGQGYPGGQGYPGSQGHPGGQGYPGGQGYPGGQGYPGGQGYPGGQGYPGGQGYPGGQGYPGGQGYPGGQGGGGWNNQGGTGWYPYNQAGNRYTQQSGSGWPIRNQDSNWNPNRQTPNSQGTNSWPQTGTGPNWNSQGTNGWYPSIQSDSTKRWTNLNGYGSDGNLRSRGLYQNNNDRRSDLLRSKFYYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U145</accession>
    <name>A0A0N4U145_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4661</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U145"/>
    <dbReference type="STRING" id="318479.A0A0N4U145"/>
    <dbReference type="WBParaSite" id="DME_0000030101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000030101-mRNA-1"/>
        <property type="gene ID" value="DME_0000030101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804825at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000030101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24497" checksum="017FC057B450B3E9" modified="2015-12-09" version="1">MDKCIFCGWARRSSSPSIRFFGIPKEPGLKRVQWLYAIGGREITSKDRVCSLHFRQGRPSSDPSHEDFVPHLYLNRDTPPEIIQCLESLAEKKMEPEWFIENENYGSYSSTGLGRICRPLILQRKRKVVSERSETETVKEVEVNSAPQPSHSVGETSTLKKETIDEVSNTVVGDAKKAKLQILQRPLVEAVGVKPGQTVIIKRRFPIFKPSQQQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1D4</accession>
    <name>A0A0N4U1D4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DME_LOCUS4770</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001150">
        <property type="protein sequence ID" value="VDN54797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1D4"/>
    <dbReference type="STRING" id="318479.A0A0N4U1D4"/>
    <dbReference type="WBParaSite" id="DME_0000041001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000041001-mRNA-1"/>
        <property type="gene ID" value="DME_0000041001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851612at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="6">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDN54797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="DME_0000041001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70575" checksum="6EC910F92717A432" modified="2015-12-09" version="1">MEADNTQNNNIFIQGLTQSNRSLAAKNQELRLQLAAEKAKVAELQKETVLLREKNVHLELADDSKRCELMVANNLQKKIKQFVAIANRAKNYLSKTVTDFDNIMRSIEASIDEGEAIRFASFNDDERSIFPRSFETIDEEYHVQSNLPTISFPCSGEDSADISGQNNLGKNSVRQNHLNSSTDLPRSGKDRRRAAVFFREGCVNFCPVLDHAHIRQAAVSQKLADFQSSSSNSLFEIVAKESLFNNAVKSVSNNGFSDSSMCEKSSDIRISPKILPNFGSNSLNEPDKELNDGTACVSSNEFPVVTNSNTSGRPLNFGISPKSIETTESQKLRQHLLCDGYRFRKDHVNVHGTTSWRCVEKDCKGRLKSDKSETIVIVRDHNHAPTPGRNAVAKAMAELRRRARTTMDKPRQIIEQTFNGIPLESISTLPSFASSQRTIERVFSAQFSAPRTIVCILSWKVHSRLYIFLSTNFCLDNFEIPLSNQILFANDESHSNVNVAPNQSSDLQSDAGKNDLVKKENSPSTFDSTAKIQEKLVEDVANNAISMFSISLKASDSFLQNEVIEILDDDDDPRSTKERVEEINQAGISIKSESGSFSEENEAYSRPKRVAAERIESLKEVNLKKKMRNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1T3</accession>
    <name>A0A0N4U1T3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">GTP-binding protein Rheb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DME_LOCUS4948</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1T3"/>
    <dbReference type="STRING" id="318479.A0A0N4U1T3"/>
    <dbReference type="WBParaSite" id="DME_0000058801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000058801-mRNA-1"/>
        <property type="gene ID" value="DME_0000058801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDN54975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="DME_0000058801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20809" checksum="86447C9AD1490CF3" modified="2015-12-09" version="1">MANVVQRKIALMGYPCVGKSSITLRFVYGSFPDAYDTTIEDIHEKICHFNGRRFSMQITDTAGQQEYSLFPRSCALDIDGYILVYAIDDKKSFDILSTIHDKILENCGDKNVPLVVVGNKLDLQHNSRQVTTNEGKHLASSWNAAFLETSAKDNTAVQQIFDLVLREIEIANGNMKRQEKNCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1V1</accession>
    <name>A0A0N4U1V1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4972</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN54999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1V1"/>
    <dbReference type="STRING" id="318479.A0A0N4U1V1"/>
    <dbReference type="WBParaSite" id="DME_0000061201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000061201-mRNA-1"/>
        <property type="gene ID" value="DME_0000061201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN54999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000061201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45467" checksum="15B68BF5901700D2" modified="2015-12-09" version="1">MDVSIGSAFQTSNESSRRKKRRLATDDYSFATSENFDTTDKMEEARSNFFNMVKSGENFDIAIDNWIKIYENHPDNALQQLQQFFISCCGCERMISSFMLQTMRYDEIILQMTEHFVDDAENYPLVMVGPKFSDFKQNFADFITLFDITCQILTLFPKLFVNKGEANYVSDWRIMDAVIKLLTALSNSQVQAFRHTSTFAAMKLLSALIDIAVPQEKNVMQIETRKDESKTKDTSNHLRSSIFNECELVEKSNIYKMVSYLFKNVFVRRYRDFLPEIRNICIIELGKWLKSYPEIFLIDSYLKYIGWLLHDKVVSKIRLSCVTSLLPLYDLPEMAKKLEFFTNKFQKRFVSLVMDKDYEVATFACKLLTGICSLYYNIIIALYYVIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U1W5</accession>
    <name>A0A0N4U1W5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS4987</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U1W5"/>
    <dbReference type="STRING" id="318479.A0A0N4U1W5"/>
    <dbReference type="WBParaSite" id="DME_0000062701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000062701-mRNA-1"/>
        <property type="gene ID" value="DME_0000062701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF84">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN55014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000062701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63556" checksum="A93821E135FDDCC8" modified="2015-12-09" version="1">MAVNSRRQFQQEADNNVWPPAVAEHLRPAPVEPGARGQIASHPYDCMTLTCLCPYFFGTIGPQNTCIMQNGQPLTMAFRKEYRMLTDDERNRWHNALIEIKRNGEYDRMGFEHQTILIFSNPLSNGWQNVINYRRIVGTFTGNINNLSFQVGIGSGAHSGPGFLPWHREYLKRFEIALRLVDPSVSIPYWDSVLDNYLPDPRDSILFSPLFAGETDWWGNVVNGPFAYWSTLDGRSAILRELAQEGALFSEFAISQIRGKKENEIFKGCPYPVNFGAVEYSHSNVHLWVGGHMKPPESSSNDPLFYTLHSFVDFIWELWRQLRQPNWSRESAYPPDLPQCADPQHFSYASMRPYYNLINRDGLSNMYTDQMYRYAPRPGCSIELPTCGSQYLFCDTRGTPHCVSKIKVNGNCFGFEGFDACFNGICVLGRCVLGPTPTPFVPTTPSPPPVRTQTPRSIQVFRNCFNRDPCCEQWGRDGECSRNSNYMRRFCPAACNICRPTYSTNNECADRHISCKQWGSQGFCRGNSEQFMQENCRTTCNLCNRPKNAQCLKSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U202</accession>
    <name>A0A0N4U202_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5031</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U202"/>
    <dbReference type="WBParaSite" id="DME_0000067101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000067101-mRNA-1"/>
        <property type="gene ID" value="DME_0000067101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041081238" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000067101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8775" checksum="A63E273E34007B7A" modified="2015-12-09" version="1">MISSVIFFLISLSYVHLEIQREFNVSESVPRGHVIGYVNNSATIGVQPNYYIIFPDGIADVDKVSMKFIIFSYSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2E2</accession>
    <name>A0A0N4U2E2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nup54 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5201</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001151">
        <property type="protein sequence ID" value="VDN55228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2E2"/>
    <dbReference type="STRING" id="318479.A0A0N4U2E2"/>
    <dbReference type="WBParaSite" id="DME_0000084101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000084101-mRNA-1"/>
        <property type="gene ID" value="DME_0000084101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000084101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51314" checksum="1A1F04DBCB0D3F29" modified="2015-12-09" version="1">MGICHFPLWYCVGEISAARTLFGPTTPAATTTTTSLLSSTAATSFKPSGLFSAPVIQPTVSQAAPTYMPTLQDIIQNSDALIRCSTSPELYGDERDSLIAKFNQLQAACGVGKGYYKTDLPPLEFKVDGPFYLYKAVVYNRNSDYKESDGMVVLTLSVPYEQITDGVRQKLVDALNVILGNNINLRAHLEHVRTLPGNNTEVLFYVTEKGKVRISSMELYNYLKQPAQEAELKNQLYVSSIVPRARIEGTALQNYLQNPPSGFDAQIWQQAINDNPDPEKLIPYVIRGFEELRTRQELQISQTNDQNRALDALKARVQATHGSIIDGQNELCYYHQKQKQLSHRILRCLSLQFLIQRYSVSVDEQEEKLESHLEAVNASILGPNQLKIYVRHLTQMFRDNREALKNSIPPNIAISKAYIDQLRRYLGRVQNALEKVVSIIESDKNDLEIVTRNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2G9</accession>
    <name>A0A0N4U2G9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EKC/KEOPS complex subunit CGI121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS5234</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2G9"/>
    <dbReference type="STRING" id="318479.A0A0N4U2G9"/>
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        <property type="gene ID" value="DME_0000087401"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:EKC/KEOPS complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN55261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000087401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20815" checksum="A96862F24DD4A319" modified="2015-12-09" version="1">MRILSKLFELQPDPFDFSQRRFFRLSLYKDVKNAVELREALRCGSIDAALIRAELCLEVFMVLAAANRAVHQAAHNRLSTRSLHAELVYSLSPTRNIAESLLNFGISETSKNLLIGLFDDENGEKMKELSKKIDGKSVNLDDLPKFTNYDLIKKVYKVGDSEFNHETICDLIVMKIATKDSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2P3</accession>
    <name>A0A0N4U2P3_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DME_LOCUS5323</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2P3"/>
    <dbReference type="STRING" id="318479.A0A0N4U2P3"/>
    <dbReference type="WBParaSite" id="DME_0000096301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000096301-mRNA-1"/>
        <property type="gene ID" value="DME_0000096301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001152">
        <property type="entry name" value="Cleavage and Polyadenylation Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000089">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="9">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="10">
        <location>
            <begin position="160"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDN55350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="DME_0000096301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46983" checksum="D366BB3BDB1C56D9" modified="2015-12-09" version="1">MGKKETLFSSFRQLFYDGHQQLALNLATTIGCSAQPPPPSDKLFRLVSMAKQFIDEHDSKEKDFVLQVEGISTGLDLEFDADIEPTSPEPSMYETIYLTSHKSPCRASAFNNDGTLLATGSADCSIKILDVERILAREVRGEVNLTENGPDAQHPIIRTLYDHIDEVNCIAFHPREQIVISGANDFTVKMFDFSKTAVKRAMKTIFEVEPIRALSFHPAGEFLLVATNHPTLRLYNIETQQCYVCSVPTDQHRDTVMDVNYSDNARLYVTGSKDGDVKVWDGISNRCVETFQRAHDGAQITSAAFTRNGKYILTSGLDSIVKLWELSTNRCLIAYTGAGATGAQEYPIQASFNHNEDYVLFPDEKSGSLCSWDARNSDRKRLLALGHTAATRTFTHSPTMPAFVTGSDDFRARFWYKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U2Y8</accession>
    <name>A0A0N4U2Y8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5429</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U2Y8"/>
    <dbReference type="WBParaSite" id="DME_0000106901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000106901-mRNA-1"/>
        <property type="gene ID" value="DME_0000106901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855077at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000106901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40453" checksum="FC475A610FED226F" modified="2015-12-09" version="1">MIVNKSFDFLNSVHLFSVAVYLFLMVSYAIVLLIFLTTLVAEITELSSKIICPFFGVFVVFTVIFGGYTAVSAITFILQFTIVIGGFGLFFYQSAGKLLFIPDFMSNDKDFSIFDSILTSSIGFLNGLHFASASPLLYQICLFTSGALITTSSLGILNFDIRFLENISLIFFGLSTMASPITAIFLTGYLLPHSGWRATVIGILNGYIAIFMVLFLKFSSILNISLGTACVNSTSDLNDVLQLSENFSVITSLISEGSILQTNTSLLEIFPLSSLPIFAFMITILSIIISSLCLNETNPLALDWNLVIYSSFPSLCFNRRINANSRQRQRQAFVESESFRYAQQTPYPETNHFPKENSFLKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3A9</accession>
    <name>A0A0N4U3A9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3485 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5568</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001152">
        <property type="protein sequence ID" value="VDN55595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3A9"/>
    <dbReference type="WBParaSite" id="DME_0000120801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000120801-mRNA-1"/>
        <property type="gene ID" value="DME_0000120801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871106at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039120" evidence="1">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000120801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29484" checksum="402D9DC4341E6995" modified="2015-12-09" version="1">MKILLLSVTLSVVVLEGEKITRENMPAAKYYDGKKFVIPIAHKTMEDIRDRWLQQAMSGLITGVSLKNSVNLSVKNKIWLKICIKRSKNVNEQARCVIEALGPRKFYKMDLPRIVQIWSLPLRNFNDHRNQPNEDEWIGGFFMFQARRFENRESDITSQNNYKLLTENANRSPFGFIAEFLKKNIQYIKEKTDSKPWFIVLARFEQLEAELKMHDELKRTLMGELKLFSEGRIKELLLELNNPDVFVYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3T4</accession>
    <name>A0A0N4U3T4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5757</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3T4"/>
    <dbReference type="WBParaSite" id="DME_0000139701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000139701-mRNA-1"/>
        <property type="gene ID" value="DME_0000139701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5801935at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000139701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26710" checksum="DCF641F8933742EB" modified="2015-12-09" version="1">MSNLIDLDLQIGLVIKAWMTMNYALLAGLQFSRNIFLLFSLYDPCVVITTTINCKLQGFPIIYCYLHGAVLVFILSLLTLWPMKEDRRLLSWASSCSIWYSVIAALCIAATLIFTAFDADHSSILQQDVISIETLIWQISFLFSGIFVIYQFAANCVCEQCLFIAFELSFFVLPLTVSFIHPLLIIWHILPLRNAAVRIFPALSFIVPEYSFVPPPPVHGLISSNNYHNNYHDSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U3V1</accession>
    <name>A0A0N4U3V1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS5779</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U3V1"/>
    <dbReference type="WBParaSite" id="DME_0000141901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000141901-mRNA-1"/>
        <property type="gene ID" value="DME_0000141901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876175at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN55806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000141901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57107" checksum="ED4FC4CD66683F18" modified="2015-12-09" version="1">MVDAREGQRKLDEISKNSVDSNDDEILPLNKKTEVAPKVDQFRTAKDQQKLYESYAKDNNKSLKLTEKGKISERKEGKQNFINISKSTSVTNENSDLDMEFSSNEKPRQCEKEKGSTKDDERPTTASEFAKTVDLYLQIQEVKSHFQKCLSEERAKLKNSTENIFKPIESIDLNESGTKIIGNLSERNGHSTVNRRQALVFRNSGVDFDLYTGYRSDKNFLSANHQNNNDNTIRKKFRRKLSCISEKSVEHLNENKEVLPTSTSCPSTTRCSAKKVRHFRRKPLPNQFLENINFKNISDVRRKQGKKEEKNYVCAERNYHRKQCQENRNDFDKKPPTSGSTSLNASKMAFNEVYNTARKYSKEMRNTEYLSNTVRKNSLNRELADFINLHVKRRPPWDSSPLRENELDRIAPIRTFLNLPGSSNSRPVKTFSRVTRSLVNSPKHRSLSLTKPGKSSSLLNFAAGKSGLLFTQRPPSISNLDPLIKENLWWGHKSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U416</accession>
    <name>A0A0N4U416_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS5857</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U416"/>
    <dbReference type="STRING" id="318479.A0A0N4U416"/>
    <dbReference type="WBParaSite" id="DME_0000149701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000149701-mRNA-1"/>
        <property type="gene ID" value="DME_0000149701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN55884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000149701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12665" checksum="0955B37D97ED6216" modified="2015-12-09" version="1">MSQQGELVEQLEHEQEAGFKLGHSCADQIFILRRMLEYYFRYLQPTVDFAVAFDSIEALWRMMECDGVPEIFRFIKIFYMSAEIAIDWVMDTACRHSRGVQSRASSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U443</accession>
    <name>A0A0N4U443_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-nucleotidase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DME_LOCUS5894</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001153">
        <property type="protein sequence ID" value="VDN55921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U443"/>
    <dbReference type="STRING" id="318479.A0A0N4U443"/>
    <dbReference type="WBParaSite" id="DME_0000153401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000153401-mRNA-1"/>
        <property type="gene ID" value="DME_0000153401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409330at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDN55921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="DME_0000153401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="52149" checksum="8E7933D80AAA9EF0" modified="2015-12-09" version="1">MTRRSFCDLSITADRLRKIYERQKNLSFQSTVIEDINPRNVFCNSALDLKKTKIYGFDYDYTLAIYKTSLNKLIYDLAMGRLIKHFKYPKQLLDIPYDPNFAIRGLHYDIENSCLLKRRELMQLSDLFSLPWAGLLSTVVQYFDENSIDFDPSCTFEDIEASVRYIHSTGLMHNTVMHNLKEYVHKNIGLKEYLSRLVDKGKKNRGMCYMLDENWRDYFECIVVMAKKPIFFKGRAPFRLYHENDDSLSYEKVTFLRKGTIYAGGNIQTLSLQPFFEGKEVLYFGDHIYVDLADPVLSLGWHTAAIVPELAREIRLQNDPKYRCAVIWLQSLTSLIENYQNSVTRDREVANLITAWLNERRIIRQRIKEMFNPQFGSMFRTYHNMSYFSRRLNRLSHIYTSRLPNMLRYSDNHVFFPQRNALPHELQMFNIPEFTEKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U5S1</accession>
    <name>A0A0N4U5S1_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein jagunal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS6574</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U5S1"/>
    <dbReference type="STRING" id="318479.A0A0N4U5S1"/>
    <dbReference type="WBParaSite" id="DME_0000221401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000221401-mRNA-1"/>
        <property type="gene ID" value="DME_0000221401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8914197at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN56601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000221401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22477" checksum="E0EA2863FD0BC67D" modified="2015-12-09" version="1">MSSRFGPRALGTDGTDFRHRQRIAFHYQFSAQYKTYLKIIFFFHFLVLIVMWLKVGGEILVHDLSLQWSYYSSLDLPSAYPWEYVWSLSFISIILGLASFRRNKINLLRMSYYSEFVFGILPCAVGLGSLLPELIDYLSDMENSQTPTFKGSFPMVIIWYIFFIVVLQIHIFSMYFSYHLLAAWQPQVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U626</accession>
    <name>A0A0N4U626_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS6706</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001156">
        <property type="protein sequence ID" value="VDN56733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U626"/>
    <dbReference type="STRING" id="318479.A0A0N4U626"/>
    <dbReference type="WBParaSite" id="DME_0000234601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000234601-mRNA-1"/>
        <property type="gene ID" value="DME_0000234601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN56733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000234601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="760" mass="86711" checksum="0319EF28A17B915D" modified="2015-12-09" version="1">MEMVVRSAQMVSYLTDLYGNEKENASAEASDENNNITSLRQCLKRMNLLKERYEACKQTMNDLISNYDAVTEQTSSLHNVCDRMMAHQTQIAAGAEQIRANLYYYTQCDIIMKKLISGKLAVTNQSFMQLLATIDECLTFLHNHPHYKDSSVYITKYEQCLSKAITAIRTGVILDLEACYNAVRDRQSLLDADSQNNDEDEFALLYGVFAVRAASVQSSIIIAEQRFAQLAEFQSMAFDCQQAYFNIRRQLVEPVLQKTIEQLLSRNSDSSCALTRNGCAFLLRLCDDEFRLYKQFFNLEDTSSHSSLSSPVTKAVFNPFISSVNSFDEFIESLCRIFYDVLRPIIIHNPHLETLAELCTILKVEMIEKRCGLMISMAKTRVEDDAAITNEARVNKFSVNPRSGFMRVMNELVGDIAERIVYRTSLYIQSDIIGFNPSSGDLAYPDKLLMMKKIEREHATETGAVTSTLTTISVVDLHCLWYPTVSRSVVCLSKLFKCLESVVFQSIARDLLKACCESLEYASESIKTTNTKQTSRSQRQLDADLFIVKHLLILREQTSPYRATASGLFSTDMIPERAYSWDLGKYKKSASHLLFERQRWFELTSNNAFLELLFQALSESSGDSRRIIDLQLKKHCHALIQHTADIFISEVVDYVNKFEAMAAEPDFDISKLDFLKPNNLQDIAGQASRKLKHCWPEIRSSFDLYIGVKDTEDILLQPIKKRIADIFGRLTAFVEKYYDAEQKQIACIPSQENIWLIINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6J7</accession>
    <name>A0A0N4U6J7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variable large protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS6911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001157">
        <property type="protein sequence ID" value="VDN56938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6J7"/>
    <dbReference type="WBParaSite" id="DME_0000255101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000255101-mRNA-1"/>
        <property type="gene ID" value="DME_0000255101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865666at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN56938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000255101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="15429" checksum="416E901A7744B61D" modified="2015-12-09" version="1">MKVIYFLEVKSNAMSNGIGDISQSKVSAQHFKNADGLIGVNVSSVGNATGAGKTNSLSSIYGASGINGTGNAAAMGSRANSITDLFGEILGGKQIVNLYNQASGIGVNDTSAVASGNGVITNGTHGGKYSILFNLLNKHFYEMNFSQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U6T3</accession>
    <name>A0A0N4U6T3_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IPT/TIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DME_LOCUS7013</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001158">
        <property type="protein sequence ID" value="VDN57040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U6T3"/>
    <dbReference type="STRING" id="318479.A0A0N4U6T3"/>
    <dbReference type="WBParaSite" id="DME_0000265301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000265301-mRNA-1"/>
        <property type="gene ID" value="DME_0000265301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25246at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11606">
        <property type="entry name" value="COE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000002">
        <property type="entry name" value="Transcription factor unc-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000007">
        <property type="entry name" value="Transcription factor unc-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="11">
        <location>
            <begin position="285"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDN57040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="DME_0000265301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55985" checksum="3F2A6851246E30BE" modified="2015-12-09" version="1">MFGFQDANLLRQMKEEPLGLRAHWATTVLDTSPARTTNFIILVANCDVFILQLSCSIKLILRISFFISQLARAHFEKHPPNNLRKSNFFHFVIALYDRAGQPVEIERTQFTDFIEKEREVDGQDTRNGIHYKLWLSFANGIRTEQDLYVRLIDSVSKQAIAYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLGVTARVDGPLLAISDNMFVHNNSKHGRRIKRIDPSEDISDSSDITSATNPVIKAICPSEGWTQGGTSVIIIGENFFEGLQVSFGPTTVWNESIQVITPHAMRVATPPRHMPGVVEVTLTYKSKQLNRGNPGRFAYISLSEPSIDFGFQRLQKLLPKYPGDPERLPKELILKRAAELAEALYNSQQFALPPPRTPADHLSHYASAYSAQFDTNADYTRSHTSPRALSTYGSGTTPHSLSSAVYQGTYSSVSASPAAQFLNGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7K5</accession>
    <name>A0A0N4U7K5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS199</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="UYYG01000001">
        <property type="protein sequence ID" value="VDN50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7K5"/>
    <dbReference type="STRING" id="318479.A0A0N4U7K5"/>
    <dbReference type="WBParaSite" id="DME_0000297001-mRNA-1">
        <property type="protein sequence ID" value="DME_0000297001-mRNA-1"/>
        <property type="gene ID" value="DME_0000297001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="406"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="432"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000297001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55715" checksum="F7F9086A149B29E8" modified="2015-12-09" version="1">MPRTYDEECSFIERVSAVQFRIKKGFVPNMNVEGRFYVNNALEKLMFEELRNASRSDGIGGFLPAVRQIGNVAALPAIVSASIGLPDIHSGYGFAIGNIAAFDVSDQKAIVSPGGVGFDINCGVRLIRTSLSENDVQPVKEQLAQSLFDHIPVGVGSKGIIPIGASQFEECLEMGMDWTLREGYSWAEDKEHCEEYGRMLQADSTKVSPRAKKRGLPQLGTLGAGNHYGEVQVVDEIYDKYAASKMGIDHIGQVCVMIHCGSRGLGHQIATDSLVAMEKAMKRDAIVVNDRQLACARISSVEGQEYLKGMAAAANFAWVNRSCMTFCARQAFAKVFNMSPDDLDMQVIYDVSHNIAKIEEHLIDGRPKQLCIHRKGSTRAFPPHHPLIPVDYQLSGDIKSQPVLIGGTMGTCSYVLTGTQQGMNETFATTCHGAGRALSRAKSRRNIDFQDVLDRMKQLGISIRVASPKLVMEEAPESYKNVTDVVNTCHEAGISRKTVKLRPVAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U7L4</accession>
    <name>A0A0N4U7L4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7141</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001159">
        <property type="protein sequence ID" value="VDN57168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U7L4"/>
    <dbReference type="WBParaSite" id="DME_0000298201-mRNA-1">
        <property type="protein sequence ID" value="DME_0000298201-mRNA-1"/>
        <property type="gene ID" value="DME_0000298201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831841at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000298201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49310" checksum="EB806714193B8D53" modified="2015-12-09" version="1">MVTERGDENFLAKLGESCTENDGKRSISPINDLAKANQSIAQAFGYKAQPSLSDANRFNRERGMEIVNMASKYEALVYYKRKDPSNYGLNSDACLSLRRSVVARNMNKVQNIDSGSIYDINSIHVSPVVEGISGETIDNINLLGILKDGSVENIVREDDKPSNDLLKFLQECRESTSTDGLVSGTPIPITNQQKKERAMFVCQTAEKFEVFESNSRSYQMNAERNELWKKIAALTNEKYGAELGNLTVEQIKKLCANYKRKYPSTFGSALKSVKMEDETVGQTEYSSVQSPQIDFDSESSSTSDFLSRITSTTSCRITKNLSEGANDLIGSLILGKNSDARCRFGSHSDSTFNASTGEPSYIELLALISSRDDEIAQLKRKLEQQSIEHKIHISRLFDKMSAVIKEALSDCVRNELLHTLNGSLSVVNSDNNMISNNTDDDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8B4</accession>
    <name>A0A0N4U8B4_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7433</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001160">
        <property type="protein sequence ID" value="VDN57460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8B4"/>
    <dbReference type="STRING" id="318479.A0A0N4U8B4"/>
    <dbReference type="WBParaSite" id="DME_0000327401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000327401-mRNA-1"/>
        <property type="gene ID" value="DME_0000327401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000327401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28141" checksum="41C119B561297FC9" modified="2015-12-09" version="1">MAEQSVNVCDGSGENSGTPHPVGDIEMKEPEEDLIEIGYVSHKCESNIVCRGSIDKIPYFNAEIYTKEQKIGIVGDIFGKVDDHGFLIILGPGLRASLFERNQKVFANRLRLLSYDTIDPTLARTAEQEAEIVLPQGQRNSRNRSRKRKGGRGSSRRGDSRFRRTDRIDGEYRRAAVGRSVRGRFRGAVWSRTEFRRTDPTGSEYGWGFYSGGSSGRGHRGTYSGWLREITHRTRPYRGHNPSAQGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8P6</accession>
    <name>A0A0N4U8P6_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4509 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS297</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8P6"/>
    <dbReference type="STRING" id="318479.A0A0N4U8P6"/>
    <dbReference type="WBParaSite" id="DME_0000343101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000343101-mRNA-1"/>
        <property type="gene ID" value="DME_0000343101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN50324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000343101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45547" checksum="DADA03E4DFE07AF2" modified="2015-12-09" version="1">MEQTVEAKVDNKTETQFSQSAVTVVPSDLLKPPPLLLLLIEKMTSGARKFVVLDFGVPILLTDLIIPSTAEVASVTVDVWLLGESIDGQRLLYSSEISKKNVVLQDIAPFMLIRYLKLTYTGCHMFSPTCRIPLGMFFGHRFFCSWQQYAFPVLLSQFPSCPALSSSQDSQSISLVHLQQFSEDLRCRHQLASAELKQLVRIRSDEKEVFYLYNECLQLRIQWNIVRGVVNRLEYDQMINKGYDEPLQKSWKECCSDQLRIIAEELFALLRQCYSLLDVRYYSDASSSKFVPEAVIETITKKKENSTALNVPSLVDIRSLPQFLDLHGALRIFDLFCTQTVPKLRAECASWLLVQGVEMDWWPKFFPNVLKKFFSASGKRGDQGLAIFENLGLKSLFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Q2</accession>
    <name>A0A0N4U8Q2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS303</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Q2"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Q2"/>
    <dbReference type="WBParaSite" id="DME_0000343701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000343701-mRNA-1"/>
        <property type="gene ID" value="DME_0000343701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF139">
        <property type="entry name" value="SEMAPHORIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000343701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="73009" checksum="A6C45827B347348E" modified="2015-12-09" version="1">MVFCFLDNVFSQGNLSYRKMLLDPKSASLYVGANGNLFKLWAYNINETIDGLYARVELSVSDRVNEECRQMGHIECVNGIRLLFLTEDRQTLLVCSSNAIKPQLHEFDAKALQQRTFPENVIGICSPDPHMNTTAIYVEWGNPGNIPSFYSGIRTGLSLDNHLIYRPPLMLDNKEIYSSVRTIYTDSKWLNGINFLIEKPQFVASLSSGNYVYFFFREVALEHGNYDRVIYSRVARLCKMDVGGKIVLRQVWTSFVKARLNCSIPSQFPFYFDHIQSVYSVEDSSDTLIYATLTASDILFGGSAVCIFSLNAINQLFDQGVFMEISTSSSSWTITAPEDIPVYRPGSCSPNSADIPDGDLHFAKSHLLMADAVSGATLLALPNELFTHIVVDVVGDSIYVVFVYSHHSRTLHKFIHWNGITEPRSKLLITYSLSTPLPAFSITILPGEFLYFSDEQMVSQYSLAQCKSYTTCAKCAIDPYCSWNSARSLCYKRNTDHSSAIGWVSVGPEDNNKCAASIKRISMKAYQGDALHLICDSLPTLWKFNDEIIQSSTQKVFTMAGGMVLFNVSSLDNGVYECSSNDDVVVLYDIEIDETECAQPTTLAQFQSTYREWCRKFSNYKLSIDRWQRWYDRNVCALYESKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8Q9</accession>
    <name>A0A0N4U8Q9_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="20">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DME_LOCUS311</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8Q9"/>
    <dbReference type="STRING" id="318479.A0A0N4U8Q9"/>
    <dbReference type="WBParaSite" id="DME_0000344501-mRNA-1">
        <property type="protein sequence ID" value="DME_0000344501-mRNA-1"/>
        <property type="gene ID" value="DME_0000344501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014897at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF128">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDN50338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="DME_0000344501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30133" checksum="3EE0E4424F64F895" modified="2015-12-09" version="1">MVFSAFKARFNHIVEHFTGNVIRLICKECPMLTFLNGHQMRQHHLENHLEILYRCAICQKIFNTQNRFQQHLNVHNEEIMQYQCAACNTLFESNDLLAIHVQLIHDRPINHISNVGDSGDQITPISIDRNLSSISSATDNRSVKCLVCDIKFENDEELDSHRLYCHCKIPRSDRCAECQEKIHNISQFIDHTRKHMSEQTTACIVCRQALRNEAQIESHAKFHMHMQERNDDMITGQIAEISEHETDWRCIICLQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U8R5</accession>
    <name>A0A0N4U8R5_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS317</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01000002">
        <property type="protein sequence ID" value="VDN50344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U8R5"/>
    <dbReference type="STRING" id="318479.A0A0N4U8R5"/>
    <dbReference type="WBParaSite" id="DME_0000345101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000345101-mRNA-1"/>
        <property type="gene ID" value="DME_0000345101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041039165" evidence="1">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="132"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="255"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN50344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000345101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49088" checksum="1DFAE41919460F42" modified="2015-12-09" version="1">MNSSIICLIIAFVFAIVILAQEEWRVPDPPENVRCKTNGDSATLWWDPPASVNEILVRGYTVSYGIGTPSQKVIIEGANTNAFTINGLKPNTTYVFVLTAYNEAVGEDSEKVLLTATTEAKKSSNRIFKLHPPTNIRGKALSPSEIEIRWTDPNLNYENMVEPRFRKRIYIRLLRRKAKHHSCIYLRYGIHKSTIFEKISSRSQQIAISGLQPGAEYEIAVKVVMSDGLESAWSIRELINTPTEDSALRSFQLNTTCNFEFSMCGFESALDAPLKWIRIHPAANEQRLSRHMDGGDYYMVLQSSPSNDDRYGRLLSKFYYYKNGSSICINMKIFVPQNSYGVFTVSIFAENGDMFAHNQILFIAYLEKIQKEHWQTISLDVKSPGKFKLIIEVRKKEDKDFSVALDDINVFSGSCAIEKNAVPRLLAQYLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U929</accession>
    <name>A0A0N4U929_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EMI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7578</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001161">
        <property type="protein sequence ID" value="VDN57605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U929"/>
    <dbReference type="STRING" id="318479.A0A0N4U929"/>
    <dbReference type="WBParaSite" id="DME_0000357301-mRNA-1">
        <property type="protein sequence ID" value="DME_0000357301-mRNA-1"/>
        <property type="gene ID" value="DME_0000357301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6053916at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000357301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33934" checksum="68341A77B200BDD0" modified="2015-12-09" version="1">MNALVTWKSLWVFEFRIQAFIVKQLWLIIQIQSIIFRREELSLQKHERPVILETIKPCWDITQGFRCKVKSNGTKLSYKGIPVKVKNLVKKCCLGFYQTQEATCEKCLEGFYGNNCSIQCNCTTPEICDNMIGCCEPESNSCRSSHKEYLVQATANKRLTMIMIGIVTAVAIFLFGVAFFYRKKYHKEKDPDLPTLTYYPHVKEFLPPSDIESREFNNPLYRQSIVEPVKPNTQEIDKFKTSRMEPTMNDYATLDEVSISLAGPSSTDPLLTDRKSPYEVPYSQDSVSSILEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U987</accession>
    <name>A0A0N4U987_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7641</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001162">
        <property type="protein sequence ID" value="VDN57668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U987"/>
    <dbReference type="STRING" id="318479.A0A0N4U987"/>
    <dbReference type="WBParaSite" id="DME_0000363601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000363601-mRNA-1"/>
        <property type="gene ID" value="DME_0000363601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF41">
        <property type="entry name" value="TROPONIN I 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000363601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17486" checksum="EC2235A0EE04B728" modified="2015-12-09" version="1">MSTSGRANDIDGEEEDDASKRAAAERERKKAEVRKRLEEAGRAKKAKKGFLTPERKKKLRKLLMMKAAEDLKQQQMLKEQERQRVLQERIIPLPDLDSLGQEELEEIAKDMVDRLMLLESENYDINYTVRQKDFEINELTIAVNDLRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9N2</accession>
    <name>A0A0N4U9N2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reelin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DME_LOCUS7811</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9N2"/>
    <dbReference type="WBParaSite" id="DME_0000380601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000380601-mRNA-1"/>
        <property type="gene ID" value="DME_0000380601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6418377at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF42">
        <property type="entry name" value="DEFENSE PROTEIN L(2)34FC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDN57838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="DME_0000380601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25420" checksum="1575028D52498DF4" modified="2015-12-09" version="1">MRFYYSFQKLGTILMKFLIYLLIFFGEALFWPDGAPCKYSTMKSMNPLEAVEHEGGLQLSNPPYAIDVVHKCYWKNQPIFLKLRGTSRNFIFKGFVIQAFIFRERKKEKRAGKFVRLDNNGSWRHQCYRFHDSVTNAHDEKKNEINLWWKNDKDDDKVVQFVATVVKSRKEFWVQSILSRPVAPCRMQREFNNYESERITAPPKIIPFALANKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4U9Q0</accession>
    <name>A0A0N4U9Q0_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DME_LOCUS7832</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001163">
        <property type="protein sequence ID" value="VDN57859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4U9Q0"/>
    <dbReference type="STRING" id="318479.A0A0N4U9Q0"/>
    <dbReference type="WBParaSite" id="DME_0000382701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000382701-mRNA-1"/>
        <property type="gene ID" value="DME_0000382701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847865at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDN57859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="DME_0000382701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41147" checksum="5931DE719B34FA41" modified="2015-12-09" version="1">MNTEEYLLKLLYPFTKPQMNGTEFVSGDNLGEMIFISKKLTSITLYWMSVAIATNIKINGFDRVKQTIKVLGIADETNEEGINYATTSVTTPVIGATSGNEFEIFPQFPESDAAAESVITVDDTMSIATNVSGDEQQFIPYNAPDDVFNDMDVAVAEEALADESIKFNRSYKLELTKLVNVLTVLLDDLNIALFSFKGTSYIEGCASKLEIGEKLNEVHCDVLNSTNARCDEQKIEKITFEGSPSLRFEFQHPSDNSKSFLQVNIKDLNIDVHDEIVSHLSHFIMDEEKADSAFKLRVNVSNMRLVIIDPKTTSPLRMKINDCVIEQGDDDTRKKYQTLFHTILMLHKAILNSLSGKKYGSMEDQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA01</accession>
    <name>A0A0N4UA01_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4203 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS7952</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA01"/>
    <dbReference type="STRING" id="318479.A0A0N4UA01"/>
    <dbReference type="WBParaSite" id="DME_0000394701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000394701-mRNA-1"/>
        <property type="gene ID" value="DME_0000394701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN57979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000394701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20229" checksum="C1FA731B47D2005F" modified="2015-12-09" version="1">MKSAFTCLLLLSIWCTLIIIPNQIWFAIGILILLDVSLIGLLIWQRRDHFLLSWIIVSCCIILLIAAPISSLTSLAILLLFLCYTLLPLQIFHSIIAAIFISFTAIIIRFISTKTSKQVIVEILTLFAMNLIGLSVYYPNELIQRKTFRQTRSHCFYVSEIKRKQIIKQQRKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UA03</accession>
    <name>A0A0N4UA03_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS7954</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="UYYG01001164">
        <property type="protein sequence ID" value="VDN57981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UA03"/>
    <dbReference type="STRING" id="318479.A0A0N4UA03"/>
    <dbReference type="WBParaSite" id="DME_0000394901-mRNA-1">
        <property type="protein sequence ID" value="DME_0000394901-mRNA-1"/>
        <property type="gene ID" value="DME_0000394901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN57981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000394901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34416" checksum="48C7A7AC8F4F6F8E" modified="2015-12-09" version="1">MVFSGSSHSDLTQRICERLQLDVSKASLKKFSNRETNVEIGESVRGEDVYIVQSACGEINDHIMELLIMINACKMASSSRVTAVIPCFPYARQDKKDKSRAPITAKLVANILSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIANWQNVVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGNVKDKVALLVDDMADTCGTICLAAEKLIEAGASAVYAFCVHGIFSGPAIERLNNSTFEAVVVTNTIPQEENMKKCSKIQCIDVSMILAEAIRRTHNGESVSYLFSHVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAE5</accession>
    <name>A0A0N4UAE5_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DME_LOCUS8001</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAE5"/>
    <dbReference type="STRING" id="318479.A0A0N4UAE5"/>
    <dbReference type="WBParaSite" id="DME_0000411801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000411801-mRNA-1"/>
        <property type="gene ID" value="DME_0000411801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF456">
        <property type="entry name" value="CD63 MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDN58028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="DME_0000411801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23252" checksum="F61FEE42A349B1B6" modified="2015-12-09" version="1">MEIQVGGLALVIAGAVLQLKYTGLLDILGDERLATPVLLLAAGALCALLGFLGCCGAIRENYCLTVSFAVLLALVLLIETATAIAAYALHEPLQASLSKQLTLGLSRYNRSVGVTMAWDQTQTQFSCCGVHNYTDWVVPPDSCCIHHSPGCGRIQQNLYSTEKNVEGCMASLEQWLIMNAALVGGISALVGSLQVIGICFACCLSKSILRDFHDFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAJ2</accession>
    <name>A0A0N4UAJ2_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DME_LOCUS8057</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001165">
        <property type="protein sequence ID" value="VDN58084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="318479.A0A0N4UAJ2"/>
    <dbReference type="WBParaSite" id="DME_0000417401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000417401-mRNA-1"/>
        <property type="gene ID" value="DME_0000417401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="590"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDN58084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="DME_0000417401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="649" mass="72296" checksum="571CB627AE4F9FD6" modified="2015-12-09" version="1">MVSSFTLEQFFDACESWNLEEVHKIINSGFNIDSFDDDHVTSLQMAAATGNIGIVEFLLDQGADIEKSNQVGMTPLHHACKNGHIHVVRILIQRGANYQKLTYLGASPMTLAAAGGHLDLIKLLLDLKVSVNPTHTALCPTPIIAAAFRRHTHICALLTHRGAYLDGHIQRLANLSALSTVIICGKIPMLTALLELGANPHFRSLREQTALELAKSLKRNDVIELLTSKTLVSAKEKPSEVDLRERIIRNDEEAVKNILHNKIPYLPFPENTSPLMYAVLTADTPILKTIIEADNNNINMAESVSGLTSLMFATIIGNHEAVQILLDAGADVSLKSFDGNLSSDLLCRLQQLEIGSLPPTKIETYHNFGRMIHSSSAKILNKLAHHVPHVPLGMTVNFSRNSTKNDDDNNMWRENFKNLLRVYDNNDNNDVFITASDILRSIAPAMKSSKIDKKHNCIRLGRTLAEMYLSHGLLPSPIGFLVENSKSNPALLNYGKFDLLSSSKSSNERRFDKSNNVTRHQSSIERGSSSTLGTTPRMRKRSQGTITVNNNNGVEESGRLSPSRHSLNQYTFALKEDDKPLRKNHSKRIWNLMIESGLDNYIELFRSEEIDKTTFLSLTNDDLIDLGIRNATHRNRILKLVKDLNNGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAT8</accession>
    <name>A0A0N4UAT8_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DME_LOCUS8169</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001166">
        <property type="protein sequence ID" value="VDN58196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAT8"/>
    <dbReference type="WBParaSite" id="DME_0000428601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000428601-mRNA-1"/>
        <property type="gene ID" value="DME_0000428601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869382at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF103">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="222"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDN58196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="DME_0000428601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40516" checksum="CB5F7303974A6D70" modified="2015-12-09" version="1">MRFLETMFDRYGRLLARHPFPFIILPLLITLISSIGLLNFHSKDDIWDLYSPLNGLSRMEEKALEMFEYASSAHHYRIQILVNRKDGGNLMNMMDLNEISNMHSYVVNNISIADGNNSLTYDDICGIYCNDSNAIVLSFIQVNLRLANGRAIAIEFERQLTDVFYTANYISKKLKFSLLSRNFELKEQRQITLVALPYLAITATILTLFMVMSLTDFPLSKIGMLWAIGIPFSNILTVVPFLVITIGVDDAFLILAGWRHSKPGESLEIKSGEMLAKSGSSVTVTSITDVLCFAVGLFSNLPVVRLFCLYTSLALAVDYIYQVKLLLSFHFLSFHFLILFLNHSTDKFISSIVLFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UAZ7</accession>
    <name>A0A0N4UAZ7_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8237</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UAZ7"/>
    <dbReference type="STRING" id="318479.A0A0N4UAZ7"/>
    <dbReference type="WBParaSite" id="DME_0000435401-mRNA-1">
        <property type="protein sequence ID" value="DME_0000435401-mRNA-1"/>
        <property type="gene ID" value="DME_0000435401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000075">
        <property type="entry name" value="Transgelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF9">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000435401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15285" checksum="905AD3C3B5B6735A" modified="2015-12-09" version="1">MSSRTTAGGIGFAVMQKQASKYNEQEGQALLEWIKKLSGENINTSGDRENFLSLLKDGTLLCKLANALEANSVKKIQKPISNFACMENINSFVNAAKKLGVPTEETFQSVDLFEGRDLFSVCVTLLSLGRLVSRFYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UB17</accession>
    <name>A0A0N4UB17_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DME_LOCUS8259</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001167">
        <property type="protein sequence ID" value="VDN58286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UB17"/>
    <dbReference type="WBParaSite" id="DME_0000437601-mRNA-1">
        <property type="protein sequence ID" value="DME_0000437601-mRNA-1"/>
        <property type="gene ID" value="DME_0000437601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6136201at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009816">
        <property type="entry name" value="SPATS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623:SF11">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07139">
        <property type="entry name" value="SPATS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDN58286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="DME_0000437601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49075" checksum="73B4BE20C12C4A0B" modified="2015-12-09" version="1">MTTKEEAKRFQEAVAKVREVVRTAPKEEVALALLNYEMDINRTIQAFYEDGAKSALDTWERTGHKKKKKQVTKKKAELHSASMQTKPDAVRVSSTSAASTPVSFISNTTPLASSEIASTISQPFSPSRSSKKLQRVSNNIPFTTNGIVPIKDAKNKKQTFDNSSASNAKVPNHEFDCYNHLSSINLKVFKEVRQLIDERERHLLAELSRIHDDDAHLLKERQHTANNLVRRIERLNAMSDREQQDLLDEIKRYLQSSCFIGKQFSERQRFNCDKKAISKIIKNFGEIVTFKSSTSNIPNTISDSFPTASATSPIMENATSHSSLNSSYGEDSGIYQTSPASKGKEISKDTDNGKTVVNVSTGVLSMSSDGLSAEQLVQMTKDVQESLMAQVLISLGIDPSILSSITGKTAMPFRRRPPGGQRGGRPAGRGNIPVKVPELSILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBS4</accession>
    <name>A0A0N4UBS4_DRAME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZIP family metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DME_LOCUS8560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYYG01001169">
        <property type="protein sequence ID" value="VDN58587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBS4"/>
    <dbReference type="STRING" id="318479.A0A0N4UBS4"/>
    <dbReference type="WBParaSite" id="DME_0000467701-mRNA-1">
        <property type="protein sequence ID" value="DME_0000467701-mRNA-1"/>
        <property type="gene ID" value="DME_0000467701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF25">
        <property type="entry name" value="PRESENILIN SPE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDN58587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="DME_0000467701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9390" checksum="5E663CD3C38933F7" modified="2015-12-09" version="1">MGDFVFYSLLVGKVATSQSAMCIIGVIVGILAGLIITLTVLSENDILSPALPLSLSLGLVIHFSMAYFGENFYKQFFHQPFSFIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UBZ0</accession>
    <name>A0A0N4UBZ0_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RuvB-like helicase</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DME_LOCUS8634</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UBZ0"/>
    <dbReference type="STRING" id="318479.A0A0N4UBZ0"/>
    <dbReference type="WBParaSite" id="DME_0000475101-mRNA-1">
        <property type="protein sequence ID" value="DME_0000475101-mRNA-1"/>
        <property type="gene ID" value="DME_0000475101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="67"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDN58661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="DME_0000475101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50092" checksum="0DA9CECD41213FC2" modified="2015-12-09" version="1">MATTTIDGISIHEVLKMERIGAHSHIRGLGLSSNLEPSRIADGLVGQLEARKAAGLIVKMIQDGKISGRAVLITGEPGTGKTAIAMGISKALGEDAPFVTISASEVFSMDMSKTEALMQAFRKAVGVRIKEETEVLEGEVVSIEIDRPATGGGAKIGRLTMKTTDMETIYDLGNKMIESCIKQKVSAGDVVQIDKASGRITKIGRAFSRSQDYDAMGPQIRFVRCPDGEIQKRKETVHTVALHEIDVINSRTQGFLALFSGDIGEIKNEVREQINKKVVEWREENKAEVVPGVLFIDEVHMLDLECFSFLNRAIEADLSPILVMATNRGHEYIRGTQLVSPHGIPLDLLDRSLIVRTHPYSEKDLEDILRIRSCEESVEIEADALSILTMLAMKTSLRYAMQLISTGNILRERRRGDKVTPDDLKKVYTLFIDQKRSEKFLKDFQNYFIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N4UC12</accession>
    <name>A0A0N4UC12_DRAME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DME_LOCUS8661</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Dracunculus medinensis</name>
        <name type="common">Guinea worm</name>
        <dbReference type="NCBI Taxonomy" id="318479"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Dracunculoidea</taxon>
            <taxon>Dracunculidae</taxon>
            <taxon>Dracunculus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYYG01001170">
        <property type="protein sequence ID" value="VDN58688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N4UC12"/>
    <dbReference type="STRING" id="318479.A0A0N4UC12"/>
    <dbReference type="WBParaSite" id="DME_0000477801-mRNA-1">
        <property type="protein sequence ID" value="DME_0000477801-mRNA-1"/>
        <property type="gene ID" value="DME_0000477801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000038040">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274756">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
   
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